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Search of human proteins with 116268109
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116268109 nucleotide-binding oligomerization domains 27
[Homo sapiens]
(1866 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 3730 0.0
gi|118918429 NOD3 protein [Homo sapiens] 172 3e-42
gi|11545912 nucleotide-binding oligomerization domain containing... 139 3e-32
gi|5174617 nucleotide-binding oligomerization domain containing ... 132 2e-30
gi|156938336 class II transactivator [Homo sapiens] 132 4e-30
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 128 6e-29
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 103 2e-21
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 103 2e-21
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 101 6e-21
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 97 1e-19
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 97 2e-19
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 96 3e-19
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 92 6e-18
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 91 8e-18
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 91 1e-17
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 91 1e-17
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 91 1e-17
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 91 1e-17
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 91 1e-17
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 90 2e-17
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 88 7e-17
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 86 3e-16
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 83 3e-15
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 3730 bits (9673), Expect = 0.0
Identities = 1866/1866 (100%), Positives = 1866/1866 (100%)
Query: 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNK 60
MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNK
Sbjct: 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNK 60
Query: 61 LHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTSQLGAEGKSQPESQLHHGL 120
LHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTSQLGAEGKSQPESQLHHGL
Sbjct: 61 LHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTSQLGAEGKSQPESQLHHGL 120
Query: 121 KRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQPHAFHQVYVPPI 180
KRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQPHAFHQVYVPPI
Sbjct: 121 KRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQPHAFHQVYVPPI 180
Query: 181 LRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVNKGPRVTVLLGKAGMGKTTLAHR 240
LRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVNKGPRVTVLLGKAGMGKTTLAHR
Sbjct: 181 LRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVNKGPRVTVLLGKAGMGKTTLAHR 240
Query: 241 LCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
LCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD
Sbjct: 241 LCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Query: 301 QVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAA 360
QVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAA
Sbjct: 301 QVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAA 360
Query: 361 MVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLL 420
MVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLL
Sbjct: 361 MVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLL 420
Query: 421 PDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDI 480
PDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDI
Sbjct: 421 PDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDI 480
Query: 481 APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQY 540
APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQY
Sbjct: 481 APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQY 540
Query: 541 VTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK 600
VTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK
Sbjct: 541 VTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK 600
Query: 601 KLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEH 660
KLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEH
Sbjct: 601 KLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEH 660
Query: 661 REAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLG 720
REAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLG
Sbjct: 661 REAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLG 720
Query: 721 LAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSN 780
LAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSN
Sbjct: 721 LAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSN 780
Query: 781 SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGA 840
SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGA
Sbjct: 781 SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGA 840
Query: 841 QSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA 900
QSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA
Sbjct: 841 QSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA 900
Query: 901 RKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAF 960
RKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAF
Sbjct: 901 RKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAF 960
Query: 961 LDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEG 1020
LDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEG
Sbjct: 961 LDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEG 1020
Query: 1021 AARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDK 1080
AARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDK
Sbjct: 1021 AARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDK 1080
Query: 1081 TSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLEL 1140
TSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLEL
Sbjct: 1081 TSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLEL 1140
Query: 1141 QLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRS 1200
QLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRS
Sbjct: 1141 QLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRS 1200
Query: 1201 LHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGL 1260
LHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGL
Sbjct: 1201 LHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGL 1260
Query: 1261 RCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSR 1320
RCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSR
Sbjct: 1261 RCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSR 1320
Query: 1321 EDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAG 1380
EDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAG
Sbjct: 1321 EDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAG 1380
Query: 1381 LFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVAL 1440
LFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVAL
Sbjct: 1381 LFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVAL 1440
Query: 1441 RLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFR 1500
RLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFR
Sbjct: 1441 RLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFR 1500
Query: 1501 LTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHL 1560
LTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHL
Sbjct: 1501 LTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHL 1560
Query: 1561 LLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGD 1620
LLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGD
Sbjct: 1561 LLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGD 1620
Query: 1621 AGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
AGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL
Sbjct: 1621 AGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
Query: 1681 GLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELP 1740
GLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELP
Sbjct: 1681 GLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELP 1740
Query: 1741 LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKR 1800
LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKR
Sbjct: 1741 LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKR 1800
Query: 1801 VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQP 1860
VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQP
Sbjct: 1801 VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQP 1860
Query: 1861 QAPWGT 1866
QAPWGT
Sbjct: 1861 QAPWGT 1866
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 172 bits (436), Expect = 3e-42
Identities = 240/938 (25%), Positives = 363/938 (38%), Gaps = 102/938 (10%)
Query: 215 TRVNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHL-NCFQALFLFEFRQLNLITRFLTP 273
+RV+ PRV++ +G AGMGKTTL + WA G + F + FR LN T
Sbjct: 132 SRVSVPPRVSITIGVAGMGKTTLVRHFVRLWAHGQVGKDFSLVLPLTFRDLN------TH 185
Query: 274 SELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPM---------GPDGPGPV 324
+L D + H + LLI DGLDE P+ P PV
Sbjct: 186 EKLCADRLICSVFPHVGEPSLAVAVPARALLILDGLDECRTPLDFSNTVACTDPKKEIPV 245
Query: 325 LTLFSHLCNGTLLPGCRVMATSRP---GKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFS 381
L +++ G L P + TSRP G++P L M + GF+ ++ + F
Sbjct: 246 DHLITNIIRGNLFPEVSIWITSRPSASGQIPGGLVDR--MTEIRGFNEEEIKVCLEQMFP 303
Query: 382 AQPSREG-ALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMT---- 436
+ G L ++Q + L +C VPA C++ + L HL Q L P T
Sbjct: 304 EDQALLGWMLSQVQADRALYLMCTVPAFCRLTGMALGHLWRSRTGPQDAELWPPRTLCEL 363
Query: 437 -QLYMQMVLA------------LSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDIAPP 483
Y +M L+ + H + LG +A GL K +FY +D+
Sbjct: 364 YSWYFRMALSGEGQEKGKASPRIEQVAHGGRKMVGTLGRLAFHGLLKKKYVFYEQDMK-- 421
Query: 484 LIAFGATHSLLTSF-CVCTGPGHQ----QTGYAFTHLSLQEFLAALHLM-ASPKVNKDTL 537
AFG +LL C C + Y FTHLSLQEF+AA + AS + D
Sbjct: 422 --AFGVDLALLQGAPCSCFLQREETLASSVAYCFTHLSLQEFVAAAYYYGASRRAIFDLF 479
Query: 538 TQ---------YVTLHSRWVQRT-KARLGLSDHLPTFLAGLASCTCRPFL--SHLAQGNE 585
T+ ++T QR +A G D FL+GL S L S LAQG
Sbjct: 480 TESGVSWPRLGFLTHFRSAAQRAMQAEDGRLDVFLRFLSGLLSPRVNALLAGSLLAQGEH 539
Query: 586 DCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPY-QLPFHNF 644
+ A ++Q L + + + HC+ E Q ELA +++ L
Sbjct: 540 QAYRTQVAELLQGC--LRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGALARLTG 597
Query: 645 PLTCTDLATLTNILE--HREAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAF 702
P LA L + + +EA + L L+ P+ L L + + D
Sbjct: 598 PAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQLL----YCRKLRLDTNQFQDPV 653
Query: 703 AEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLN 761
E L L R+Q + LA ++I+ +G L ++L + L + R N + Q
Sbjct: 654 MELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKA 713
Query: 762 IVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQARE-------ADLIFLL 814
+ + L L L L N++ +A + T+ ML ++ A +
Sbjct: 714 LADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADA 773
Query: 815 SPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQ---VHDA--EALIALLQEG 869
+ EL + + G + A++ + L+ LQ + DA AL+ L
Sbjct: 774 LKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTN 833
Query: 870 PHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLA 929
L + L N + EG + +A A + LDL+ N L G + AV TL
Sbjct: 834 QTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLT 893
Query: 930 ELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEK 989
LH LQ + AQ + LD + + + R + L
Sbjct: 894 SLH--LQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTAL 951
Query: 990 HLEQLCKALGGSCHLGHL--------HLDFSGNALGDEGAARLAQLLPGLGALQSLNLSE 1041
+L+ G+ LG LD GNA+G GA LA L +L+ LNL E
Sbjct: 952 YLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQE 1011
Query: 1042 NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGD 1079
N L +D + C +T L + QHI L+G+
Sbjct: 1012 NSLGMDGAI----CIAT-----ALSGNHRLQHINLQGN 1040
Score = 128 bits (321), Expect = 6e-29
Identities = 133/456 (29%), Positives = 201/456 (44%), Gaps = 22/456 (4%)
Query: 1391 ADRARVLSLLEVCAQASGSVTEISISETQ---QQLCVQLEFPRQEENPEAVALRLAHCDL 1447
A RA + LL+V + A +S+S +Q Q L QL + R+ LRL
Sbjct: 599 AHRAALAYLLQV-SDACAQEANLSLSLSQGVLQSLLPQLLYCRK--------LRLDTNQF 649
Query: 1448 GAHHSLLVGQLME-TCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCV 1506
L+G ++ R+Q++SL++ + + + L +SLL++ S L + L + +
Sbjct: 650 QDPVMELLGSVLSGKDCRIQKISLAENQI--SNKGAKALARSLLVNRS-LTSLDLRGNSI 706
Query: 1507 STEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSST 1566
+G LA L L L L N ++G +++ AL L L L +
Sbjct: 707 GPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMG 766
Query: 1567 LALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHL 1626
+ L Q L+ L + NSIGD G L+EAL+ LE LDL N I DAGV L
Sbjct: 767 AQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAAL 826
Query: 1627 ATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL 1686
L L + L NSIS G +A +L L+ L L N L D A +A +
Sbjct: 827 MGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAV 886
Query: 1687 PQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL----AGGVLRFCMELP 1740
++ L LHL ++ + G A +L QAL + L + L EN + A V R
Sbjct: 887 RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNT 946
Query: 1741 LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKR 1800
L + L I A++L + LE++ L N +G A LA L L+R
Sbjct: 947 ALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRR 1006
Query: 1801 VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1836
++L++N + GA +A L+ +Q I L N I
Sbjct: 1007 LNLQENSLGMDGAICIATALSGNHRLQHINLQGNHI 1042
Score = 116 bits (291), Expect = 2e-25
Identities = 135/468 (28%), Positives = 202/468 (43%), Gaps = 50/468 (10%)
Query: 1388 EPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQ-LEFPRQ-EENPEAVALRLAHC 1445
E A R +V LL+ C + +V +I+ +Q E R EE E+ AL A
Sbjct: 538 EHQAYRTQVAELLQGCLRPDAAVCARAINVLHCLHELQHTELARSVEEAMESGAL--ARL 595
Query: 1446 DLGAHHSLLVG--QLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTS 1503
AH + L Q+ + CA+ LSLS S +LQSLL L + RL +
Sbjct: 596 TGPAHRAALAYLLQVSDACAQEANLSLS---------LSQGVLQSLLPQLLYCRKLRLDT 646
Query: 1504 SCVSTEGLAHLASGL-GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLL 1562
+ + L S L G ++++ L+ NQ +G KAL R+L L+
Sbjct: 647 NQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSL--------------LV 692
Query: 1563 NSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAG 1622
N S L SL L NSIG G L++AL+ +L L L N + D G
Sbjct: 693 NRS--------------LTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDG 738
Query: 1623 VQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGL 1682
+ +A L L + L NSI G ++A++L R L+ELM N++GD A L
Sbjct: 739 ARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKAL 798
Query: 1683 AQELP--QHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL----AGGVLRFC 1736
A+ L Q L L L + + G +L AL + L +SL EN++ A +
Sbjct: 799 AEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHAL 858
Query: 1737 MELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
L+ +DL + + +Q A+ + + L + L WN + AA L Q L
Sbjct: 859 CANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNR 918
Query: 1797 RLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHL 1844
L +DL++N I GA +A L +++ + L I AQ L
Sbjct: 919 SLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVL 966
Score = 100 bits (248), Expect = 2e-20
Identities = 137/529 (25%), Positives = 206/529 (38%), Gaps = 59/529 (11%)
Query: 1198 LRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGD 1257
L L H L E E R TG + H +L +LL +Q ANL
Sbjct: 571 LHELQHTELARSVEEAMESGALARLTGPA----HRAALAYLLQVSDACAQ---EANLSLS 623
Query: 1258 SGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIH 1317
L LPQ+ L L N Q+ + LL ++ S
Sbjct: 624 LSQGVLQSLLPQLLYCRKLRLDTNQF-QDPVMELLGSVLS-------------------- 662
Query: 1318 FSREDQAGKTLRLSECSFRPEHVSR-----LATGLSKSLQLTELTLTQCCLGQ---KQLA 1369
GK R+ + S +S LA L + LT L L +G K LA
Sbjct: 663 -------GKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALA 715
Query: 1370 ILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFP 1429
L + R SL+ D AR + A+A S +S+ Q+ +
Sbjct: 716 DALK-INRTLTSLSLQGNTVRDDGARSM------AEALASNRTLSMLHLQKNSIGPMGAQ 768
Query: 1430 RQ----EENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLL 1485
R ++N L + +G + + + ++ L+ L L ++ DA
Sbjct: 769 RMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSI---SDAGVAA 825
Query: 1486 LQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRA 1545
L L + L + L + +S EG +A L L+ LDL+ N ++G +A+ A
Sbjct: 826 LMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVA 885
Query: 1546 LEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAA 1605
+ L L L + + L L L SL L N+IGD G C ++ AL+
Sbjct: 886 VRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVN 945
Query: 1606 TSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLE 1665
T+L L L IG +G Q L L L +DL GN+I AG LA +L + L
Sbjct: 946 TALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLR 1005
Query: 1666 ELMLGCNALGDPTALGLAQELPQHLRVLH--LPFSHLGPGGALSLAQAL 1712
L L N+LG A+ +A L + R+ H L +H+G GA +++A+
Sbjct: 1006 RLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAI 1054
Score = 66.6 bits (161), Expect = 2e-10
Identities = 96/405 (23%), Positives = 150/405 (37%), Gaps = 55/405 (13%)
Query: 1227 LSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQE 1286
+S + ++L L + L+ +DL N +G G + L + L L L N++ +
Sbjct: 678 ISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDD 737
Query: 1287 SALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATG 1346
A + E L S ++ L L + S P R+A
Sbjct: 738 GARSMAEALAS------------------------NRTLSMLHLQKNSIGPMGAQRMADA 773
Query: 1347 LSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLL-EVCAQ 1405
L ++ L EL + +G L + GL SL +Q A V +L+ +C
Sbjct: 774 LKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTN 833
Query: 1406 A---SGSVTEISISETQQQ-----LCVQLEFPRQE-------------------ENPEAV 1438
S S+ E SIS Q LC + EN
Sbjct: 834 QTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLT 893
Query: 1439 ALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKT 1498
+L L + A + +GQ ++ L L L + + DD + + ++L ++ + L
Sbjct: 894 SLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAI--GDDGACAVARALKVNTA-LTA 950
Query: 1499 FRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLS 1558
L + + G L L LE LDL N G KAL AL+ L+RL+L
Sbjct: 951 LYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQ 1010
Query: 1559 HLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALR 1603
L + LS LQ + L N IGD G +SEA++
Sbjct: 1011 ENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIK 1055
Score = 55.5 bits (132), Expect = 5e-07
Identities = 92/439 (20%), Positives = 156/439 (35%), Gaps = 57/439 (12%)
Query: 839 GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLH 898
G R + L + Q+ A+AL L L +DL GN + +G + +A+A
Sbjct: 663 GKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINR 722
Query: 899 IARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERA 958
L L N + G + A+++ TL+ LH LQ ++ GP
Sbjct: 723 TLTSLSLQGNTVRDDGARSMAEALASNRTLSMLH--LQKNSI------------GPMGAQ 768
Query: 959 AFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGD 1018
D+L S + + + + + + L +AL + G LD N++ D
Sbjct: 769 RMADALKQNR------SLKELMFSSNSIGDGGAKALAEAL--KVNQGLESLDLQSNSISD 820
Query: 1019 EGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQH----- 1073
G A L L L SL+L EN +S + + L LD++ H
Sbjct: 821 AGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGAR 880
Query: 1074 ---ILLRGDKTSRDMWATGSLPDFPAAAKFLG--FRQRCIPRSLCLSECPLEPPSLTRLC 1128
+ +R ++T + + AA+ LG + SL L E + +
Sbjct: 881 AIAVAVRENRTLTSLHLQWNFIQ-AGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVA 939
Query: 1129 ATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLS 1188
LK L L + + L + L L +L L + LAN L
Sbjct: 940 RALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALK 999
Query: 1189 LCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQV 1248
+ +++++L+ SL + + LS L +
Sbjct: 1000 VNSSLRRLNLQE------------------------NSLGMDGAICIATALSGNHRLQHI 1035
Query: 1249 DLSANLLGDSGLRCLLECL 1267
+L N +GDSG R + E +
Sbjct: 1036 NLQGNHIGDSGARMISEAI 1054
Score = 38.5 bits (88), Expect = 0.062
Identities = 49/213 (23%), Positives = 80/213 (37%), Gaps = 16/213 (7%)
Query: 681 ALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPL 740
AL ++NL + D A A++ ++ L L L + I A L +AL L
Sbjct: 857 ALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQL 916
Query: 741 CPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTV 800
L + ++N + D + L L L L SI S L T+
Sbjct: 917 NRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTL 976
Query: 801 RMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAE 860
+L R + I + A L+ + R+ L LQ+ L + A
Sbjct: 977 EILDLR-GNAIGVAGAKALANA-------LKVNSSLRR--------LNLQENSLGMDGAI 1020
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEA 893
+ L L+ ++L GN + D G R+++EA
Sbjct: 1021 CIATALSGNHRLQHINLQGNHIGDSGARMISEA 1053
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 139 bits (349), Expect = 3e-32
Identities = 219/868 (25%), Positives = 333/868 (38%), Gaps = 152/868 (17%)
Query: 145 KKYLQLLRT--SAQQRYRSQIPGSGQPHAFHQVYVPPILRRATASLDTPEGAIMGDVKVE 202
KKY+ LRT SAQ R+ S G+ + +Y +L + M +
Sbjct: 220 KKYMAKLRTTVSAQSRFLSTYDGA-ETLCLEDIYTENVL-------EVWADVGMAGPPQK 271
Query: 203 DGADVSISDLFNT--RVNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGH-LNCFQALFLF 259
A + + +LF+T +N +++G+AG GK+TL RL WA G F +F F
Sbjct: 272 SPATLGLEELFSTPGHLNDDADTVLVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPF 331
Query: 260 EFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDE-------A 312
RQL + + L+ LLF+ P+ + +FQ L + D+VLL FDG DE
Sbjct: 332 SCRQLQCMAKPLSVRTLLFEHCCWPDVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDR 391
Query: 313 LQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAE-AAMVHMLGFDGPR 371
+ P P V TL +L G LL R + TSRP + A L ++ GF
Sbjct: 392 ERHCSPTDPTSVQTLLFNLLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQG 451
Query: 372 VEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVAL 431
+E Y+ + + LQ L LC +P + C LL G S
Sbjct: 452 IELYLRKRHHEPGVADRLIRLLQETSALHGLCHLPVFSWMVSKCHQELLLQE--GGSPKT 509
Query: 432 LPNMTQLYMQ-MVLALSPP-------------GHLPTSSLLDLGEVALRGLETGKVIFYA 477
+M L +Q +L +PP G LPT LL LG +AL GL +F A
Sbjct: 510 TTDMYLLILQHFLLHATPPDSASQGLGPSLLRGRLPT--LLHLGRLALWGLGMCCYVFSA 567
Query: 478 K-----DIAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKV 532
+ ++P I+ G L+ + V G F H++ Q F AA +L S V
Sbjct: 568 QQLQAAQVSPDDISLG---FLVRAKGVVPG---STAPLEFLHITFQCFFAAFYLALSADV 621
Query: 533 NKDTLTQYVTLHSRWVQRTKARLGLSDHLPT----------------------------- 563
L +++ R ARL LPT
Sbjct: 622 -PPALLRHLFNCGRPGNSPMARL-----LPTMCIQASEGKDSSVAALLQKAEPHNLQITA 675
Query: 564 -FLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTG------------- 609
FLAGL S L+ Q +E + +QA L + +
Sbjct: 676 AFLAGLLSREHWGLLAE-CQTSEKALLRRQACARWCLARSLRKHFHSIPPAAPGEAKSVH 734
Query: 610 --PKVVELCHCVDETQEPELASLTAQSLPY-QLPFHNFPLTCTDLATLTNILEHREAPIH 666
P + L + E QE LA A+ L L + T+ A L +L+H P+
Sbjct: 735 AMPGFIWLIRSLYEMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVA 794
Query: 667 LDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKI 726
L D GD E L LP +G + L L + I
Sbjct: 795 LQLD------------------------YNSVGDIGVEQL---LPCLGVCKALYLRDNNI 827
Query: 727 TARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVST 786
+ RGI L++ C QL++++ +N+L+D ++ ++L L L +N I +
Sbjct: 828 SDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAG 887
Query: 787 LLCLA---RVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSR 843
LA R + + R D + A L E+ G + +
Sbjct: 888 AQVLAEGLRGNTSLQFLGFWGNRVGD---------------EGAQALAEALGDHQSLRWL 932
Query: 844 SLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKL 903
SL + A+AL +L + LEE+ L N L+DEG +AE + + L
Sbjct: 933 SLVGN----NIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKIL 988
Query: 904 DLSDNGLSVAGVHCVLRAVSACWTLAEL 931
LS+N ++ G +L+A+ T+ E+
Sbjct: 989 KLSNNCITYLGAEALLQALERNDTILEV 1016
Score = 88.6 bits (218), Expect = 5e-17
Identities = 81/275 (29%), Positives = 123/275 (44%), Gaps = 9/275 (3%)
Query: 1583 LRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLS 1642
L+L S+G C L+ L+ L L +N +GD GV+ L LP L + + L
Sbjct: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQL---LPCLGVCKALYLR 823
Query: 1643 GNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELP--QHLRVLHLPFSHL 1700
N+IS G +L E + C +L++L L N L D A +A+ L Q+ L L +++
Sbjct: 824 DNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNNYI 883
Query: 1701 GPGGALSLAQALDGSPHLEEISLAENNL----AGGVLRFCMELPLLRQIDLVSCKIDNQT 1756
GA LA+ L G+ L+ + N + A + + LR + LV I +
Sbjct: 884 TAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVG 943
Query: 1757 AKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLL 1816
A+ L LE + L N L DE LA+ L + LK + L N IT LGA L
Sbjct: 944 AQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEAL 1003
Query: 1817 AEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRL 1851
+ L + +I + L N + L ++ RL
Sbjct: 1004 LQALERNDTILEVWLRGNTFSLEEVDKLGCRDTRL 1038
Score = 80.9 bits (198), Expect = 1e-14
Identities = 84/317 (26%), Positives = 128/317 (40%), Gaps = 54/317 (17%)
Query: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTF 1499
L+L C +G + +++ R L L + + ++ LL L K
Sbjct: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDY------NSVGDIGVEQLLPCLGVCKAL 820
Query: 1500 RLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSH 1559
L + +S G+ L HC L++L L NN+ + ++ + L
Sbjct: 821 YLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLL------------- 867
Query: 1560 LLLNSSTLALLTHRLSQMTCLQS---LRLNRNSIGDVGCCHLSEALRAATSLEELDLSHN 1616
C Q+ LRL N I G L+E LR TSL+ L N
Sbjct: 868 ------------------ACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGN 909
Query: 1617 QIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGD 1676
++GD G Q LA L LR + L GN+I S G LA L LEEL L N L D
Sbjct: 910 RVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQD 969
Query: 1677 PTALGLAQELPQH--LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLR 1734
LA+ L ++ L++L L + + GA +L QAL+ + + E+ L N +
Sbjct: 970 EGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTILEVWLRGNTFS----- 1024
Query: 1735 FCMELPLLRQIDLVSCK 1751
L ++D + C+
Sbjct: 1025 -------LEEVDKLGCR 1034
Score = 63.9 bits (154), Expect = 1e-09
Identities = 79/310 (25%), Positives = 122/310 (39%), Gaps = 42/310 (13%)
Query: 1342 RLATGLSKSLQLTELTLTQCCLGQKQ---LAILLSLVGRPAGLFSLRVQEPWADRARVLS 1398
RLA ++ L + L LT C +G + LA +L + RP L
Sbjct: 753 RLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVAL----------------- 795
Query: 1399 LLEVCAQASGSVTEISISETQQQLCV-QLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQ 1457
SV +I + + L V + + R + +L C L
Sbjct: 796 -----QLDYNSVGDIGVEQLLPCLGVCKALYLRDNNISDRGICKLIECAL---------- 840
Query: 1458 LMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASG 1517
C +LQ+L+L L D + + LL RL ++ ++ G LA G
Sbjct: 841 ---HCEQLQKLALFNNKL---TDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEG 894
Query: 1518 LGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQM 1577
L L+ L N+ +EG +AL AL L+ L L + S L L++
Sbjct: 895 LRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKN 954
Query: 1578 TCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELR 1637
L+ L L N + D G C L+E L+ +SL+ L LS+N I G + L L +
Sbjct: 955 VMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGAEALLQALERNDTIL 1014
Query: 1638 KIDLSGNSIS 1647
++ L GN+ S
Sbjct: 1015 EVWLRGNTFS 1024
Score = 50.4 bits (119), Expect = 2e-05
Identities = 48/166 (28%), Positives = 74/166 (44%), Gaps = 3/166 (1%)
Query: 1682 LAQELPQHLRVLHLP--FSHLGPGGALSLAQALDGSPHLEEISLAENNLAG-GVLRFCME 1738
LA++ + L V HL F +GP +LA L + L N++ GV +
Sbjct: 754 LARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPC 813
Query: 1739 LPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRL 1798
L + + + L I ++ L C L+ + L N L D A +A++L
Sbjct: 814 LGVCKALYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNF 873
Query: 1799 KRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHL 1844
+ L N ITA GA +LAEGL +S+Q + W N + + AQ L
Sbjct: 874 LALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQAL 919
Score = 39.3 bits (90), Expect = 0.036
Identities = 72/296 (24%), Positives = 111/296 (37%), Gaps = 39/296 (13%)
Query: 1112 LCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLS 1171
L L+ C + P L L+ P+ LQL + D +E LL C L L L
Sbjct: 767 LKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPC---LGVCKALYLR 823
Query: 1172 QTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQEH 1231
+S + L C +++K+ L F + + GC+
Sbjct: 824 DNNISDRGICKLIECALHCEQLQKLAL---------FNNKLTD---------GCA----- 860
Query: 1232 VESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYL 1291
S+ LL+ ++ + L N + +G + L E L L N + E A L
Sbjct: 861 -HSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQAL 919
Query: 1292 LETLPSCPRVREASV---NLGS--EQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATG 1346
E L +R S+ N+GS Q+ + ++ + L L E + E V LA G
Sbjct: 920 AEALGDHQSLRWLSLVGNNIGSVGAQALALMLAKNVML-EELCLEENHLQDEGVCSLAEG 978
Query: 1347 LSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEV 1402
L K+ L L L+ C+ LL + R + + E W R SL EV
Sbjct: 979 LKKNSSLKILKLSNNCITYLGAEALLQALER-----NDTILEVWL-RGNTFSLEEV 1028
Score = 37.4 bits (85), Expect = 0.14
Identities = 55/217 (25%), Positives = 86/217 (39%), Gaps = 26/217 (11%)
Query: 829 DLQESDGQRKGAQSRSLT-LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGC 887
++QE RK A+ ++ L+L C + + AL +LQ + L N + D G
Sbjct: 748 EMQEERLARKAARGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGV 807
Query: 888 RLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQE 947
+ L + + L L DN +S G+ ++ LH K +F
Sbjct: 808 EQLLPC---LGVCKALYLRDNNISDRGICKLIECA--------LHCEQLQKLALF----- 851
Query: 948 PEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHL 1007
K A + L+ + L L +T G Q L + L G+ L L
Sbjct: 852 --NNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQV-----LAEGLRGNTSLQFL 904
Query: 1008 HLDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGL 1044
F GN +GDEGA LA+ L +L+ L+L N +
Sbjct: 905 --GFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNI 939
Score = 33.1 bits (74), Expect = 2.6
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 5/82 (6%)
Query: 974 LSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA 1033
L+ ++LT C + L L L LD+ N++GD G + QLLP LG
Sbjct: 762 LNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDY--NSVGDIG---VEQLLPCLGV 816
Query: 1034 LQSLNLSENGLSLDAVLGLVRC 1055
++L L +N +S + L+ C
Sbjct: 817 CKALYLRDNNISDRGICKLIEC 838
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 132 bits (333), Expect = 2e-30
Identities = 184/778 (23%), Positives = 287/778 (36%), Gaps = 130/778 (16%)
Query: 217 VNKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRF-----L 271
+N+ +LG AG+GK+ L RL WA G L+ F F FR + + F L
Sbjct: 191 LNEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDA-GVKFFFHFR-CRMFSCFKESDRL 248
Query: 272 TPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMG----PDG-----PG 322
+LLF Y PE D + VF +L + L FDGLDE + PD P
Sbjct: 249 CLQDLLFKHYCYPERDPEEVFAFLLRFPHVALFTFDGLDELHSDLDLSRVPDSSCPWEPA 308
Query: 323 PVLTLFSHLCNGTLLPGCRVMATSRPG-KLPACLPAEAAMVHMLGFDGPRVEEYVNHFFS 381
L L ++L +G LL G + T+R G ++P + ++ GF + Y F
Sbjct: 309 HPLVLLANLLSGKLLKGASKLLTARTGIEVPRQFLRKKVLLR--GFSPSHLRAYARRMFP 366
Query: 382 AQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQ 441
+ ++ L +L+ N L SLC+VP C + C H A + LP+ T
Sbjct: 367 ERALQDRLLSQLEANPNLCSLCSVPLFCWIIFRCFQHF---RAAFEGSPQLPDCTMTLTD 423
Query: 442 MVLALSPPG---------------------HLPTSSLLDLGEVALRGLETGKVIFYAKDI 480
+ L ++ H +L LG+VA RG+E +F +++
Sbjct: 424 VFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLFVFTQEEV 483
Query: 481 APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQY 540
+ GPG Q Y F HL+LQ F A L+ +V L ++
Sbjct: 484 QASGLQERDMQLGFLRALPELGPGGDQQSYEFFHLTLQAFFTAFFLVLDDRVGTQELLRF 543
Query: 541 VT-----------------LHSRWVQRT-KARLGL---SDHLP---TFLAGLASCTCRPF 576
L + +Q + AR L DH FL GL S +
Sbjct: 544 FQEWMPPAGAATTSCYPPFLPFQCLQGSGPAREDLFKNKDHFQFTNLFLCGLLSKAKQKL 603
Query: 577 LSHLAQGNEDCVGAKQAAVVQ--------VLKKLATRKLTG-------PKVVELCHCVDE 621
L HL + K+ A+ LK L ++ P + + C+ E
Sbjct: 604 LRHLVPAA--ALRRKRKALWAHLFSSLRGYLKSLPRVQVESFNQVQAMPTFIWMLRCIYE 661
Query: 622 TQEPELASLTAQSLPYQLPFHNFPLTCT-DLATLTNILEHREAPIHLDFDGCPLEPHCPE 680
TQ ++ L A+ + + C+ D + L+ +L H + LD D L +
Sbjct: 662 TQSQKVGQLAARGICANYLKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVR 721
Query: 681 ALVGC-GQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALP 739
L C ++ L + D + LS L + LGL ++IT G ++ K L
Sbjct: 722 ELQPCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILD 781
Query: 740 LC----------------------------PQLKEVSFRDNQLSDQVVLNIVEVLPHLPR 771
C + EV NQ+ D+ E L + P
Sbjct: 782 ECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPS 841
Query: 772 LRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQ 831
L L L+SN I LAR + Q ++++L T EL ++
Sbjct: 842 LTTLSLASNGISTEGGKSLARA--------LQQNTSLEILWL------TQNELN--DEVA 885
Query: 832 ESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRL 889
ES + L L + Q+ L LQ + E+ L+GN ++ E ++
Sbjct: 886 ESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKV 943
Score = 82.4 bits (202), Expect = 4e-15
Identities = 80/274 (29%), Positives = 119/274 (43%), Gaps = 8/274 (2%)
Query: 1455 VGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHL 1514
VGQL L L+ N C D ++ L +L + L ++ ++ G+ L
Sbjct: 667 VGQLAARGICANYLKLTYCNACSADCSA---LSFVLHHFPKRLALDLDNNNLNDYGVREL 723
Query: 1515 ASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRL 1574
L L LS NQ + G K L L ++ L L + + +T L
Sbjct: 724 QPCFSR---LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL 780
Query: 1575 SQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLP 1634
+ L L+L +N I G +L+ A++ + S+ E+ + NQ+GD G + A L P
Sbjct: 781 DECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHP 840
Query: 1635 ELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELP--QHLRV 1692
L + L+ N IS+ GG LA +L LE L L N L D A LA+ L Q L+
Sbjct: 841 SLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKH 900
Query: 1693 LHLPFSHLGPGGALSLAQALDGSPHLEEISLAEN 1726
L L + + G LA AL + + EI L N
Sbjct: 901 LWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934
Score = 81.6 bits (200), Expect = 6e-15
Identities = 84/288 (29%), Positives = 120/288 (41%), Gaps = 53/288 (18%)
Query: 1555 LDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLS 1614
LDL + LN + L S++T L RL+ N I D G LSE L + L L
Sbjct: 708 LDLDNNNLNDYGVRELQPCFSRLTVL---RLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764
Query: 1615 HNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNAL 1674
+NQI D G +++ IL L + L N I+S GG LA ++ + + E+ + N +
Sbjct: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQV 824
Query: 1675 GDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLR 1734
GD GA + A+AL P L +SLA N
Sbjct: 825 GDE--------------------------GAKAFAEALRNHPSLTTLSLASNG------- 851
Query: 1735 FCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQ 1794
I + K L + +LE++ L+ N L DE A LA++L
Sbjct: 852 -----------------ISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKV 894
Query: 1795 MGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQ 1842
LK + L +NQITA G LA+ L + I I L N I + A+
Sbjct: 895 NQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAK 942
Score = 60.8 bits (146), Expect = 1e-08
Identities = 47/167 (28%), Positives = 76/167 (45%)
Query: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGT 1539
D + + +L L +L + +++EG +LA + + + E+ + NQ +EG
Sbjct: 770 DVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGA 829
Query: 1540 KALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLS 1599
KA AL L L L+ +++ L L Q T L+ L L +N + D L+
Sbjct: 830 KAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLA 889
Query: 1600 EALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSI 1646
E L+ +L+ L L NQI G LA L + +I L+GN I
Sbjct: 890 EMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGNLI 936
Score = 44.3 bits (103), Expect = 0.001
Identities = 57/248 (22%), Positives = 100/248 (40%), Gaps = 33/248 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLS 906
L+L C D AL +L P +DL N L D G R + S+L + R LS
Sbjct: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSRLTVLR---LS 736
Query: 907 DNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLML 966
N ++ GV + ++ + L + T + A ++ ++
Sbjct: 737 VNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV---------------GARYVTKILD 781
Query: 967 QMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQ 1026
+ L + ++T G K+L K +G GN +GDEGA A+
Sbjct: 782 ECKGLTHLKLGKNKITSEG--GKYLALAVKNSKSISEVG-----MWGNQVGDEGAKAFAE 834
Query: 1027 LLPGLGALQSLNLSENGLSLDAVLGLVRCFS-----TLQWLFRLDIS---FESQHILLRG 1078
L +L +L+L+ NG+S + L R + WL + +++ ES +L+
Sbjct: 835 ALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKV 894
Query: 1079 DKTSRDMW 1086
++T + +W
Sbjct: 895 NQTLKHLW 902
>gi|156938336 class II transactivator [Homo sapiens]
Length = 1130
Score = 132 bits (331), Expect = 4e-30
Identities = 169/605 (27%), Positives = 241/605 (39%), Gaps = 68/605 (11%)
Query: 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLY 281
RV +LGKAG GK+ A + + WA G L + +F LN +LLF L
Sbjct: 414 RVIAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLG 473
Query: 282 LSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMG---------PDGPGPVLTLFSHLC 332
P D VF ++ K D+VLLI DG +E G P P + L + L
Sbjct: 474 PQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAGLF 533
Query: 333 NGTLLPGCRVMATSRP-GKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREG--- 388
LL GC ++ T+RP G+L L A+ + GF + + YV +F + E
Sbjct: 534 QKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTEHQDR 593
Query: 389 ALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMV--LAL 446
AL L+ L S P LC+ C LL G+ L +T LY+ ++ AL
Sbjct: 594 ALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLE---LGEDAKLPSTLTGLYVGLLGRAAL 650
Query: 447 -SPPGHLPTSSLL--DLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGP 503
SPPG L + L +LG L+ + F + D+ +A G P
Sbjct: 651 DSPPGALAELAKLAWELGRRHQSTLQEDQ--FPSADVRTWAMAKGLVQH---------PP 699
Query: 504 GHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRTKARLGLSDHLPT 563
++ AF LQ FL AL L S ++ L QY+ L R + + + +P
Sbjct: 700 RAAESELAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPR---KKRPYDNWLEGVPR 756
Query: 564 FLAGLA-SCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDET 622
FLAGL R + L V KQ + + LK+L L +++EL HC E
Sbjct: 757 FLAGLIFQPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEA 816
Query: 623 QEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGCPLEPHCPEAL 682
+E + Q LP +L F LT D L LE LD + CP
Sbjct: 817 EEAGIWQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGI---CPS-- 871
Query: 683 VGCGQIENLSFKSR-KCGDAFAEALSRSLPTMGRLQMLGLAGSKIT-----------ARG 730
G G + LS +R + + AL SL G ++L A K T
Sbjct: 872 -GLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVED 930
Query: 731 ISHLVKA-------------LPLCPQLKEVSFRDNQLS-DQVVLNIVEVLPHLPRLRKLD 776
+ LV+ LP LK++ F +S Q +V +L L+ LD
Sbjct: 931 LGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLD 990
Query: 777 LSSNS 781
L + S
Sbjct: 991 LDALS 995
Score = 70.5 bits (171), Expect = 1e-11
Identities = 49/132 (37%), Positives = 73/132 (55%), Gaps = 4/132 (3%)
Query: 1542 LMRALEGKWMLKRLDLSHLLLNS---STLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHL 1598
L+R L L+ LDL L N ++ L+ Q+ L++L L++N+I D+G L
Sbjct: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKL 1035
Query: 1599 SEALRA-ATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAES 1657
+EAL + A SL L L +N I D G + LA +LP + LR +D+ N ++AG QLA S
Sbjct: 1036 AEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAAS 1095
Query: 1658 LVLCRRLEELML 1669
L C +E L +
Sbjct: 1096 LRRCPHVETLAM 1107
Score = 63.9 bits (154), Expect = 1e-09
Identities = 51/181 (28%), Positives = 85/181 (46%), Gaps = 13/181 (7%)
Query: 1683 AQELPQHLRVLHLPFSHLGPGGA-------LSLAQALDGSPHLEEISLAENNLAG-GVLR 1734
A ELP + L F+ LGP + + A HL+ +L+EN + GV +
Sbjct: 948 AGELPAVRDLKKLEFA-LGPVSGPQAFPKLVRILTAFSSLQHLDLDALSENKIGDEGVSQ 1006
Query: 1735 FCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLG----DEAAAELAQ 1790
P L+ ++ ++ +N T + P+L LL +L D A LA+
Sbjct: 1007 LSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYNNCICDVGAESLAR 1066
Query: 1791 VLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPR 1850
VLP M L+ +D++ N+ TA GA LA L + ++ + +W IP + +HL+ Q+ R
Sbjct: 1067 VLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPTIPFSVQEHLQQQDSR 1126
Query: 1851 L 1851
+
Sbjct: 1127 I 1127
Score = 48.1 bits (113), Expect = 8e-05
Identities = 34/113 (30%), Positives = 50/113 (44%), Gaps = 1/113 (0%)
Query: 692 SFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALP-LCPQLKEVSFR 750
+ K GD LS + P + L+ L L+ + IT G L +ALP L L +S
Sbjct: 993 ALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLY 1052
Query: 751 DNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRML 803
+N + D ++ VLP + LR +D+ N + LA CP V L
Sbjct: 1053 NNCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETL 1105
Score = 42.7 bits (99), Expect = 0.003
Identities = 57/225 (25%), Positives = 90/225 (40%), Gaps = 29/225 (12%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLS 906
L L C + +A ++QE P + G +L ++ +A LDL
Sbjct: 807 LELLHCAHEAEEAGIWQHVVQELPG--RLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLR 864
Query: 907 DNGL------SVAGVHCVLRAVSACWTLAELHISLQH--KTVIFMFAQEP---------- 948
G+ S+ G+ CV R +A L SLQ +T + A+E
Sbjct: 865 STGICPSGLGSLVGLSCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKS 924
Query: 949 ---EEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQE----KHLEQLCKALGGS 1001
E G + S ELP + R ++ L + +L + L
Sbjct: 925 LKDVEDLGKLVQTQRTRSSSEDTAGELP-AVRDLKKLEFALGPVSGPQAFPKLVRILTAF 983
Query: 1002 CHLGHLHLD-FSGNALGDEGAARLAQLLPGLGALQSLNLSENGLS 1045
L HL LD S N +GDEG ++L+ P L +L++LNLS+N ++
Sbjct: 984 SSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNIT 1028
Score = 41.6 bits (96), Expect = 0.007
Identities = 36/130 (27%), Positives = 57/130 (43%), Gaps = 6/130 (4%)
Query: 706 LSRSLPTMGRLQML---GLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNI 762
L R L LQ L L+ +KI G+S L P L+ ++ N ++D +
Sbjct: 976 LVRILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKL 1035
Query: 763 VEVLPHL-PRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETT 821
E LP L L +L L +N IC LARV ++R++ + F + +
Sbjct: 1036 AEALPSLAASLLRLSLYNNCICDVGAESLARVLPDMVSLRVMDVQYNK--FTAAGAQQLA 1093
Query: 822 AELQRAPDLQ 831
A L+R P ++
Sbjct: 1094 ASLRRCPHVE 1103
Score = 35.8 bits (81), Expect = 0.40
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 1238 LLSKCKDLSQVDLSA---NLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLET 1294
+L+ L +DL A N +GD G+ L PQ+ L+LS N+I+ A L E
Sbjct: 979 ILTAFSSLQHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEA 1038
Query: 1295 LPS 1297
LPS
Sbjct: 1039 LPS 1041
Score = 34.7 bits (78), Expect = 0.89
Identities = 17/49 (34%), Positives = 29/49 (59%)
Query: 700 DAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVS 748
D AE+L+R LP M L+++ + +K TA G L +L CP ++ ++
Sbjct: 1058 DVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLA 1106
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 128 bits (321), Expect = 6e-29
Identities = 217/858 (25%), Positives = 328/858 (38%), Gaps = 111/858 (12%)
Query: 221 PRVTVLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLF 278
PR V+ G AG+GK+ LAH++ WA+G L F LF R++N + +L+F
Sbjct: 210 PRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIF 269
Query: 279 DLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPM--GPDGP--------GPVLTLF 328
+ P + Q L + +++L I DG DE L+P P GP P L
Sbjct: 270 SCWPEPSAP----LQELIRVPERLLFIIDGFDE-LKPSFHDPQGPWCLCWEEKRPTELLL 324
Query: 329 SHLCNGTLLPGCRVMATSRPGKLPAC--LPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSR 386
+ L LLP ++ T+RP L L V +LGF +EY +F
Sbjct: 325 NSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQA 384
Query: 387 EGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLAL 446
++ N L ++C VP +C V C CL L G T +YM +L+L
Sbjct: 385 GQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQL--EGGGLLRQTSRTTTAVYMLYLLSL 442
Query: 447 -----SPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCT 501
P P + L +A GL K++F +D+ + G S + +
Sbjct: 443 MQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLD-GEDVSAFLNMNIFQ 501
Query: 502 GPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVT-LHSRWVQRTKARLGLSDH 560
+ + Y+F HLS QEF AA++ + Q VT L + + ++ L L+
Sbjct: 502 KDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSERSFLALTSR 561
Query: 561 LPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTGPKV-----VEL 615
FL GL + R SHL + C + +L+ + ++ + +E
Sbjct: 562 ---FLFGLLNEETR---SHLEKSL--CWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEF 613
Query: 616 CHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGCPLE 675
C+ E QE E F L+ + ++NI E H+ C
Sbjct: 614 FSCLYEIQEEE--------------FIQQALSHFQVIVVSNIASKME---HMVSSFCLKR 656
Query: 676 PHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLV 735
+ L G + + R A A L LP R +L HL
Sbjct: 657 CRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPE--RTVLLDAYS--------EHLA 706
Query: 736 KALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLC--LARV 793
AL P L E+S N L + V + + L H P + +L +S+ C L+
Sbjct: 707 AALCTNPNLIELSLYRNALGSRGVKLLCQGLRH-PNCKLQNLRLKRCRISSSACEDLSAA 765
Query: 794 AVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQ 853
+ + + + F P E R P Q R ++L+KCQ
Sbjct: 766 LIANKNLTRMDLSGNGVGF---PGMMLLCEGLRHP------------QCRLQMIQLRKCQ 810
Query: 854 LQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ-LHIARKLDLSDNGLSV 912
L+ + + ++L PHL E+DL+GN LED G RL+ + + R L L L+
Sbjct: 811 LESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTA 870
Query: 913 AGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSEL 972
A + +S +L EL +SL L L+L
Sbjct: 871 AACDELASTLSVNQSLRELDLSL--------------------NELGDLGVLLLCEGLRH 910
Query: 973 PLSS-RRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGL 1031
P + +RL C L E L L + +L L L F N LGD G LA+ L
Sbjct: 911 PTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSF--NDLGDWGLWLLAEGLQHP 968
Query: 1032 GA-LQSLNLSENGLSLDA 1048
LQ L L GL+ A
Sbjct: 969 ACRLQKLWLDSCGLTAKA 986
Score = 77.8 bits (190), Expect = 9e-14
Identities = 91/323 (28%), Positives = 124/323 (38%), Gaps = 53/323 (16%)
Query: 1513 HLASGLGHCHHLEELDLSNNQFDEEGTKALMRAL-EGKWMLKRLDLSHLLLNSSTLALLT 1571
HLA+ L +L EL L N G K L + L L+ L L ++SS L+
Sbjct: 704 HLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLS 763
Query: 1572 HRLSQMTCLQSLRLNRNSIGDVGCCHLSEALR-AATSLEELDLSHNQIGDAGVQHLATIL 1630
L L + L+ N +G G L E LR L+ + L Q+ Q +A++L
Sbjct: 764 AALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVL 823
Query: 1631 PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHL 1690
P L ++DL+GN++ G L L C L P L
Sbjct: 824 GTNPHLVELDLTGNALEDLG----------------LRLLCQGLRHPVC---------RL 858
Query: 1691 RVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAG-GVLRFCMELPLLRQIDLVS 1749
R L L L LA L + L E+ L+ N L GVL C L
Sbjct: 859 RTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGL---------- 908
Query: 1750 CKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQIT 1809
+ T KL T C LG A L+ VL L+ +DL N +
Sbjct: 909 ---RHPTCKLQTLRLGIC-----------RLGSAACEGLSVVLQANHNLRELDLSFNDLG 954
Query: 1810 ALGAWLLAEGLAQGSSIQVIRLW 1832
G WLLAEGL Q + ++ +LW
Sbjct: 955 DWGLWLLAEGL-QHPACRLQKLW 976
Score = 69.3 bits (168), Expect = 3e-11
Identities = 92/323 (28%), Positives = 129/323 (39%), Gaps = 61/323 (18%)
Query: 1434 NPEAVALRLAHCDLGAHHSLLVGQ-LMETCARLQQLSLSQVNL----CEDDDAS------ 1482
NP + L L LG+ L+ Q L +LQ L L + + CED A+
Sbjct: 712 NPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKN 771
Query: 1483 ----------------SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEE 1526
LL + L L+ +L + + +AS LG HL E
Sbjct: 772 LTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVE 831
Query: 1527 LDLSNNQFDEEGTKALMRALEGK-------WM----------------------LKRLDL 1557
LDL+ N ++ G + L + L W+ L+ LDL
Sbjct: 832 LDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDL 891
Query: 1558 SHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHN 1616
S L + LL L TC LQ+LRL +G C LS L+A +L ELDLS N
Sbjct: 892 SLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFN 951
Query: 1617 QIGDAGVQHLATILP-GLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALG 1675
+GD G+ LA L L+K+ L +++ L +L + + L +L L NALG
Sbjct: 952 DLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALG 1011
Query: 1676 DPTALGLAQELPQ---HLRVLHL 1695
D L + L LRVL L
Sbjct: 1012 DTGVRLLCKRLSHPGCKLRVLWL 1034
Score = 53.5 bits (127), Expect = 2e-06
Identities = 71/268 (26%), Positives = 114/268 (42%), Gaps = 24/268 (8%)
Query: 687 QIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKAL--PLCPQL 744
+++NL K + + E LS +L L + L+G+ + G+ L + L P C +L
Sbjct: 743 KLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQC-RL 801
Query: 745 KEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSI--CVSTLLC------LARVAVT 796
+ + R QL + VL P L +LDL+ N++ LLC + R+
Sbjct: 802 QMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTL 861
Query: 797 CPTVRMLQAREADLIFLLSPPTETTAELQRAPD-------LQESDGQRKGAQSRSLTLRL 849
+ L A D + ++ EL + + L +G R + TLRL
Sbjct: 862 WLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRH-PTCKLQTLRL 920
Query: 850 QKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA---RKLDLS 906
C+L E L +LQ +L E+DLS N L D G L+AE H A +KL L
Sbjct: 921 GICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQ--HPACRLQKLWLD 978
Query: 907 DNGLSVAGVHCVLRAVSACWTLAELHIS 934
GL+ + + TL +L+++
Sbjct: 979 SCGLTAKACENLYFTLGINQTLTDLYLT 1006
Score = 35.8 bits (81), Expect = 0.40
Identities = 66/286 (23%), Positives = 107/286 (37%), Gaps = 16/286 (5%)
Query: 1107 CIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCL--PQLPQ 1164
C ++L L C + + L A L + LS + + L + L PQ +
Sbjct: 742 CKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQC-R 800
Query: 1165 LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL--RSLHHATLHFRSNEEEEGVCCGRF 1222
L ++QL + L + +A+ L P + ++DL +L L VC R
Sbjct: 801 LQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRT 860
Query: 1223 TG---CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECL--PQVPISGLLD 1277
C L+ + L LS + L ++DLS N LGD G+ L E L P + L
Sbjct: 861 LWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQ-TLR 919
Query: 1278 LSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSE----- 1332
L + + L L + +RE ++ + + E RL +
Sbjct: 920 LGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDS 979
Query: 1333 CSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRP 1378
C + L L + LT+L LT LG + +L + P
Sbjct: 980 CGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHP 1025
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 103 bits (256), Expect = 2e-21
Identities = 194/779 (24%), Positives = 299/779 (38%), Gaps = 99/779 (12%)
Query: 225 VLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLFDLYL 282
V G AG+GKT LA ++ WA G L + F LF R+++L+T+ L DL +
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQ-----RSLGDLIM 277
Query: 283 SPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLT----------LFSHLC 332
S D + + + ++L + DG DE LQ + GP+ T L S L
Sbjct: 278 SCCPDPNPPIHKIVRKPSRILFLMDGFDE-LQGAFDEHIGPLCTDWQKAERGDILLSSLI 336
Query: 333 NGTLLPGCRVMATSRPGKLPAC--LPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGAL 390
LLP ++ T+RP L L V +LGF + +EY +FS + A
Sbjct: 337 RKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAF 396
Query: 391 VELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLA--LSP 448
+Q N L ++C +P +C + C L + G+S+A T L+ L P
Sbjct: 397 SLIQENEVLFTMCFIPLVCWIVCTGLKQQMES---GKSLAQTSKTTTAVYVFFLSSLLQP 453
Query: 449 PG----HLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPG 504
G H + L L +A G+ K++F D+ + A S +
Sbjct: 454 RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQ-KADVSAFLRMNLFQKEV 512
Query: 505 HQQTGYAFTHLSLQEFLAAL-HLMASPKVNKDTLT-QYVTLHSRWV-----QRTKARLGL 557
+ Y+F H++ QEF AA+ +L+ K + + + L SR V K G
Sbjct: 513 DCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGY 572
Query: 558 SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK----KLATRKL-TGPKV 612
+ FL GL + +L + C ++Q +++LK K +KL P
Sbjct: 573 LIFVVRFLFGLVNQERTSYL----EKKLSCKISQQIR-LELLKWIEVKAKAKKLQIQPSQ 627
Query: 613 VELCHCVDETQEPELASLTAQSLP------YQLPFHNFPLTCTD---------LATLTNI 657
+EL +C+ E QE + P H C + L L N+
Sbjct: 628 LELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNM 687
Query: 658 LEHREAP----IHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTM 713
+ E HLD C L P A G + + +F L L T
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVL-PSSSHAACSHGLVNS------HLTSSFCRGLFSVLSTS 740
Query: 714 GRLQMLGLAGSKITARGISHLVKAL--PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPR 771
L L L+ + + G+ L + L P C ++ + LS + +I VL +
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 772 LRKLDLSSNSI--CVSTLLCLARVAVTCPTVR-------MLQAREADLIFLLSPPTETTA 822
L +LDLS N++ LLC+ + C + + A DL +LS T
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 823 ELQRAPDLQESD-----GQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDL 877
L +S + K Q L L L AL ++L +L + L
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 878 SGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQ 936
GN L D+G +L+ E LH KL + + HC CW L+ L S Q
Sbjct: 920 RGNTLGDKGIKLLCEGL--LHPDCKLQVLELDNCNLTSHC-------CWDLSTLLTSSQ 969
Score = 70.5 bits (171), Expect = 1e-11
Identities = 80/280 (28%), Positives = 119/280 (42%), Gaps = 10/280 (3%)
Query: 1529 LSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNR 1587
L N+ + L L L LDLS L + +L L C ++ L L R
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 1588 NSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLP-ELRKIDLSGNSI 1646
+ C +S L + L ELDLS N +GD G++ L L L L+K+ L +
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 839
Query: 1647 SSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQ-HLRVLHLPFSHLGPG 1703
+SA LA L L L +G NALGD L ++ PQ +L+ L L S L
Sbjct: 840 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 899
Query: 1704 GALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAK 1758
+L+ L + +L + L N L ++ E L L+ ++L +C + +
Sbjct: 900 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 959
Query: 1759 LLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRL 1798
L++ TS +L + L N LGD +VL Q L
Sbjct: 960 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
Score = 67.0 bits (162), Expect = 2e-10
Identities = 93/341 (27%), Positives = 148/341 (43%), Gaps = 39/341 (11%)
Query: 1513 HLASG--LGHCHHLEELDLS---NNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1567
H+ S + +CH +E L L N +EE + EG+ LD+ +L SS+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEK-----EGR----HLDMVQCVLPSSSH 713
Query: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627
A +H L S C L L + SL ELDLS N +GD G++ L
Sbjct: 714 AACSHGLVNSHLTSSF-----------CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLC 762
Query: 1628 TIL--PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGD----PTALG 1681
L PG +R++ L +S ++ L ++L EL L NALGD +G
Sbjct: 763 ETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVG 821
Query: 1682 LAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFCMELP 1740
L + L +L+ L L L LA L S L + + EN L GV C +
Sbjct: 822 L-KHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
Query: 1741 ----LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQ-VLPQM 1795
L+++ LV+ + + L+S ++ L + L N LGD+ L + +L
Sbjct: 881 NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
Query: 1796 GRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1836
+L+ ++L+ +T+ W L+ L S++ + L NN +
Sbjct: 941 CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDL 981
Score = 62.0 bits (149), Expect = 5e-09
Identities = 71/260 (27%), Positives = 106/260 (40%), Gaps = 14/260 (5%)
Query: 1407 SGSVTEISISETQ------QQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLME 1460
S S+TE+ +S+ + LC L+ P L L C L + ++
Sbjct: 740 SQSLTELDLSDNSLGDPGMRVLCETLQHP----GCNIRRLWLGRCGLSHECCFDISLVLS 795
Query: 1461 TCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGH 1520
+ +L +L LS L D LL L L LK L S C+++ LAS L
Sbjct: 796 SNQKLVELDLSDNAL--GDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLST 853
Query: 1521 CHHLEELDLSNNQFDEEGTKALM-RALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC 1579
H L L + N + G L +A + L++L L + L S + L+ LS
Sbjct: 854 SHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQN 913
Query: 1580 LQSLRLNRNSIGDVGCCHLSEA-LRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRK 1638
L L L N++GD G L E L L+ L+L + + L+T+L LRK
Sbjct: 914 LTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRK 973
Query: 1639 IDLSGNSISSAGGVQLAESL 1658
+ L N + G + E L
Sbjct: 974 LSLGNNDLGDLGVMMFCEVL 993
Score = 52.0 bits (123), Expect = 5e-06
Identities = 106/420 (25%), Positives = 155/420 (36%), Gaps = 70/420 (16%)
Query: 1135 PGPLELQLSC-EFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRV 1193
P LEL E + ++ +D P++ + LS S F + N C RV
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIE----INLSTRMDHMVSSFCIEN----CHRV 676
Query: 1194 KKVDLRSLHHATLHFRSNEEEEG----------------VCCGRFTGCSLSQEHVESLCW 1237
+ + L LH+ EE+EG C L+ L
Sbjct: 677 ESLSLGFLHNMPKE-EEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFS 735
Query: 1238 LLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL--LDLSHNSISQESALYLLETL 1295
+LS + L+++DLS N LGD G+R L E L Q P + L L +S E + L
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETL-QHPGCNIRRLWLGRCGLSHECCFDISLVL 794
Query: 1296 PSCPRVREASVNLGSEQSFRIHFSREDQAG-----KTLRLSECSFRPEHVSRLATGLSKS 1350
S ++ E ++ + F I K L L C LA+ LS S
Sbjct: 795 SSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTS 854
Query: 1351 LQLTELTLTQCCLGQKQLAILLSLVGRP-AGLFSLRVQEPWADRARVLSLLEVCAQASGS 1409
LT L + + LG +AIL P L L + L VC A S
Sbjct: 855 HSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNS--------GLTSVCCSALSS 906
Query: 1410 VTEISISETQ-------------QQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVG 1456
V + + T + LC L P + + L L +C+L +H +
Sbjct: 907 VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP----DCKLQVLELDNCNLTSHCCWDLS 962
Query: 1457 QLMETCARLQQLSLSQVNL--------CEDDDASSLLLQSLLLSLSELKTFRLTSSCVST 1508
L+ + L++LSL +L CE S LLQ+ L LSE+ T S + T
Sbjct: 963 TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN--LGLSEMYFNYETKSALET 1020
Score = 46.2 bits (108), Expect = 3e-04
Identities = 90/380 (23%), Positives = 141/380 (37%), Gaps = 54/380 (14%)
Query: 948 PEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHL-EQLCKALGG--SCHL 1004
P+E++ ++ LD + +PS S +H GL HL C+ L S
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVLPS-----SSHAACSH-GLVNSHLTSSFCRGLFSVLSTSQ 741
Query: 1005 GHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSLNLSENGLSLDAVLGLVRCFSTLQWLF 1063
LD S N+LGD G L + L G ++ L L GLS + + S+ Q L
Sbjct: 742 SLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLV 801
Query: 1064 RLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQ-RCIPRSLCLSECPLEPP 1122
LD+S +L DF +G + C + L L C L
Sbjct: 802 ELDLS-------------------DNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSA 842
Query: 1123 SLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSL--LQLSQTGLSPKSP 1180
L + L L + L D + L + + PQ +L L L +GL+
Sbjct: 843 CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE-KAKNPQCNLQKLGLVNSGLTSVCC 901
Query: 1181 FLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCG-----------RFTGCSLSQ 1229
L++ LS + + LR + ++ + +C G C+L+
Sbjct: 902 SALSSVLSTNQNLTHLYLRG------NTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955
Query: 1230 EHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQ----VPISGLLDLSHNSISQ 1285
L LL+ + L ++ L N LGD G+ E L Q + GL ++ N ++
Sbjct: 956 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015
Query: 1286 ESALYLLETLPSCPRVREAS 1305
+ L E P V E S
Sbjct: 1016 SALETLQEEKPELTVVFEPS 1035
Score = 36.6 bits (83), Expect = 0.24
Identities = 56/223 (25%), Positives = 86/223 (38%), Gaps = 23/223 (10%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L L +C L + +L L E+DLS N L D G RL+ L +KL L
Sbjct: 775 LWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 834
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
V C L + + C LA + +S H + G +++
Sbjct: 835 ---------VSCCLTS-ACCQDLASV-LSTSHSLTRLYVGENALGDSGV--------AIL 875
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
+ + +++ L + GL L L + +L HL+L GN LGD+G L
Sbjct: 876 CEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL--RGNTLGDKGIKLLC 933
Query: 1026 Q-LLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
+ LL LQ L L L+ L ++ Q L +L +
Sbjct: 934 EGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 976
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 103 bits (256), Expect = 2e-21
Identities = 194/779 (24%), Positives = 299/779 (38%), Gaps = 99/779 (12%)
Query: 225 VLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLFDLYL 282
V G AG+GKT LA ++ WA G L + F LF R+++L+T+ L DL +
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQ-----RSLGDLIM 277
Query: 283 SPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLT----------LFSHLC 332
S D + + + ++L + DG DE LQ + GP+ T L S L
Sbjct: 278 SCCPDPNPPIHKIVRKPSRILFLMDGFDE-LQGAFDEHIGPLCTDWQKAERGDILLSSLI 336
Query: 333 NGTLLPGCRVMATSRPGKLPAC--LPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGAL 390
LLP ++ T+RP L L V +LGF + +EY +FS + A
Sbjct: 337 RKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAF 396
Query: 391 VELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLA--LSP 448
+Q N L ++C +P +C + C L + G+S+A T L+ L P
Sbjct: 397 SLIQENEVLFTMCFIPLVCWIVCTGLKQQMES---GKSLAQTSKTTTAVYVFFLSSLLQP 453
Query: 449 PG----HLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPG 504
G H + L L +A G+ K++F D+ + A S +
Sbjct: 454 RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQ-KADVSAFLRMNLFQKEV 512
Query: 505 HQQTGYAFTHLSLQEFLAAL-HLMASPKVNKDTLT-QYVTLHSRWV-----QRTKARLGL 557
+ Y+F H++ QEF AA+ +L+ K + + + L SR V K G
Sbjct: 513 DCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGY 572
Query: 558 SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK----KLATRKL-TGPKV 612
+ FL GL + +L + C ++Q +++LK K +KL P
Sbjct: 573 LIFVVRFLFGLVNQERTSYL----EKKLSCKISQQIR-LELLKWIEVKAKAKKLQIQPSQ 627
Query: 613 VELCHCVDETQEPELASLTAQSLP------YQLPFHNFPLTCTD---------LATLTNI 657
+EL +C+ E QE + P H C + L L N+
Sbjct: 628 LELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNM 687
Query: 658 LEHREAP----IHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTM 713
+ E HLD C L P A G + + +F L L T
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVL-PSSSHAACSHGLVNS------HLTSSFCRGLFSVLSTS 740
Query: 714 GRLQMLGLAGSKITARGISHLVKAL--PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPR 771
L L L+ + + G+ L + L P C ++ + LS + +I VL +
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 772 LRKLDLSSNSI--CVSTLLCLARVAVTCPTVR-------MLQAREADLIFLLSPPTETTA 822
L +LDLS N++ LLC+ + C + + A DL +LS T
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 823 ELQRAPDLQESD-----GQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDL 877
L +S + K Q L L L AL ++L +L + L
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 878 SGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQ 936
GN L D+G +L+ E LH KL + + HC CW L+ L S Q
Sbjct: 920 RGNTLGDKGIKLLCEGL--LHPDCKLQVLELDNCNLTSHC-------CWDLSTLLTSSQ 969
Score = 70.5 bits (171), Expect = 1e-11
Identities = 80/280 (28%), Positives = 119/280 (42%), Gaps = 10/280 (3%)
Query: 1529 LSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNR 1587
L N+ + L L L LDLS L + +L L C ++ L L R
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 1588 NSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLP-ELRKIDLSGNSI 1646
+ C +S L + L ELDLS N +GD G++ L L L L+K+ L +
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 839
Query: 1647 SSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL--PQ-HLRVLHLPFSHLGPG 1703
+SA LA L L L +G NALGD L ++ PQ +L+ L L S L
Sbjct: 840 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 899
Query: 1704 GALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAK 1758
+L+ L + +L + L N L ++ E L L+ ++L +C + +
Sbjct: 900 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 959
Query: 1759 LLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRL 1798
L++ TS +L + L N LGD +VL Q L
Sbjct: 960 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
Score = 67.0 bits (162), Expect = 2e-10
Identities = 93/341 (27%), Positives = 148/341 (43%), Gaps = 39/341 (11%)
Query: 1513 HLASG--LGHCHHLEELDLS---NNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1567
H+ S + +CH +E L L N +EE + EG+ LD+ +L SS+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEK-----EGR----HLDMVQCVLPSSSH 713
Query: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627
A +H L S C L L + SL ELDLS N +GD G++ L
Sbjct: 714 AACSHGLVNSHLTSSF-----------CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLC 762
Query: 1628 TIL--PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGD----PTALG 1681
L PG +R++ L +S ++ L ++L EL L NALGD +G
Sbjct: 763 ETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVG 821
Query: 1682 LAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFCMELP 1740
L + L +L+ L L L LA L S L + + EN L GV C +
Sbjct: 822 L-KHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
Query: 1741 ----LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQ-VLPQM 1795
L+++ LV+ + + L+S ++ L + L N LGD+ L + +L
Sbjct: 881 NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
Query: 1796 GRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1836
+L+ ++L+ +T+ W L+ L S++ + L NN +
Sbjct: 941 CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDL 981
Score = 62.0 bits (149), Expect = 5e-09
Identities = 71/260 (27%), Positives = 106/260 (40%), Gaps = 14/260 (5%)
Query: 1407 SGSVTEISISETQ------QQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLME 1460
S S+TE+ +S+ + LC L+ P L L C L + ++
Sbjct: 740 SQSLTELDLSDNSLGDPGMRVLCETLQHP----GCNIRRLWLGRCGLSHECCFDISLVLS 795
Query: 1461 TCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGH 1520
+ +L +L LS L D LL L L LK L S C+++ LAS L
Sbjct: 796 SNQKLVELDLSDNAL--GDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLST 853
Query: 1521 CHHLEELDLSNNQFDEEGTKALM-RALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC 1579
H L L + N + G L +A + L++L L + L S + L+ LS
Sbjct: 854 SHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQN 913
Query: 1580 LQSLRLNRNSIGDVGCCHLSEA-LRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRK 1638
L L L N++GD G L E L L+ L+L + + L+T+L LRK
Sbjct: 914 LTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRK 973
Query: 1639 IDLSGNSISSAGGVQLAESL 1658
+ L N + G + E L
Sbjct: 974 LSLGNNDLGDLGVMMFCEVL 993
Score = 52.0 bits (123), Expect = 5e-06
Identities = 106/420 (25%), Positives = 155/420 (36%), Gaps = 70/420 (16%)
Query: 1135 PGPLELQLSC-EFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRV 1193
P LEL E + ++ +D P++ + LS S F + N C RV
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIE----INLSTRMDHMVSSFCIEN----CHRV 676
Query: 1194 KKVDLRSLHHATLHFRSNEEEEG----------------VCCGRFTGCSLSQEHVESLCW 1237
+ + L LH+ EE+EG C L+ L
Sbjct: 677 ESLSLGFLHNMPKE-EEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFS 735
Query: 1238 LLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL--LDLSHNSISQESALYLLETL 1295
+LS + L+++DLS N LGD G+R L E L Q P + L L +S E + L
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETL-QHPGCNIRRLWLGRCGLSHECCFDISLVL 794
Query: 1296 PSCPRVREASVNLGSEQSFRIHFSREDQAG-----KTLRLSECSFRPEHVSRLATGLSKS 1350
S ++ E ++ + F I K L L C LA+ LS S
Sbjct: 795 SSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTS 854
Query: 1351 LQLTELTLTQCCLGQKQLAILLSLVGRP-AGLFSLRVQEPWADRARVLSLLEVCAQASGS 1409
LT L + + LG +AIL P L L + L VC A S
Sbjct: 855 HSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNS--------GLTSVCCSALSS 906
Query: 1410 VTEISISETQ-------------QQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVG 1456
V + + T + LC L P + + L L +C+L +H +
Sbjct: 907 VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP----DCKLQVLELDNCNLTSHCCWDLS 962
Query: 1457 QLMETCARLQQLSLSQVNL--------CEDDDASSLLLQSLLLSLSELKTFRLTSSCVST 1508
L+ + L++LSL +L CE S LLQ+ L LSE+ T S + T
Sbjct: 963 TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN--LGLSEMYFNYETKSALET 1020
Score = 46.2 bits (108), Expect = 3e-04
Identities = 90/380 (23%), Positives = 141/380 (37%), Gaps = 54/380 (14%)
Query: 948 PEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHL-EQLCKALGG--SCHL 1004
P+E++ ++ LD + +PS S +H GL HL C+ L S
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVLPS-----SSHAACSH-GLVNSHLTSSFCRGLFSVLSTSQ 741
Query: 1005 GHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSLNLSENGLSLDAVLGLVRCFSTLQWLF 1063
LD S N+LGD G L + L G ++ L L GLS + + S+ Q L
Sbjct: 742 SLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLV 801
Query: 1064 RLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQ-RCIPRSLCLSECPLEPP 1122
LD+S +L DF +G + C + L L C L
Sbjct: 802 ELDLS-------------------DNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSA 842
Query: 1123 SLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSL--LQLSQTGLSPKSP 1180
L + L L + L D + L + + PQ +L L L +GL+
Sbjct: 843 CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE-KAKNPQCNLQKLGLVNSGLTSVCC 901
Query: 1181 FLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCG-----------RFTGCSLSQ 1229
L++ LS + + LR + ++ + +C G C+L+
Sbjct: 902 SALSSVLSTNQNLTHLYLRG------NTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955
Query: 1230 EHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQ----VPISGLLDLSHNSISQ 1285
L LL+ + L ++ L N LGD G+ E L Q + GL ++ N ++
Sbjct: 956 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015
Query: 1286 ESALYLLETLPSCPRVREAS 1305
+ L E P V E S
Sbjct: 1016 SALETLQEEKPELTVVFEPS 1035
Score = 36.6 bits (83), Expect = 0.24
Identities = 56/223 (25%), Positives = 86/223 (38%), Gaps = 23/223 (10%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L L +C L + +L L E+DLS N L D G RL+ L +KL L
Sbjct: 775 LWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 834
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
V C L + + C LA + +S H + G +++
Sbjct: 835 ---------VSCCLTS-ACCQDLASV-LSTSHSLTRLYVGENALGDSGV--------AIL 875
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
+ + +++ L + GL L L + +L HL+L GN LGD+G L
Sbjct: 876 CEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL--RGNTLGDKGIKLLC 933
Query: 1026 Q-LLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
+ LL LQ L L L+ L ++ Q L +L +
Sbjct: 934 EGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 976
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 101 bits (252), Expect = 6e-21
Identities = 214/892 (23%), Positives = 339/892 (38%), Gaps = 86/892 (9%)
Query: 221 PRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDL 280
PR VL GK+G+GK+ LA R+ WA+G L +Q +F + F + E
Sbjct: 279 PRTVVLHGKSGIGKSALARRIVLCWAQGGL--YQGMFSYVF--FLPVREMQRKKESSVTE 334
Query: 281 YLSPE-SDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPD--------GPGPVLTLFSHL 331
++S E D + +++L I DG D+ + D P TL L
Sbjct: 335 FISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSL 394
Query: 332 CNGTLLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFS---AQPSREG 388
LLP ++ T R L +E L G E+ ++ + +
Sbjct: 395 LRKVLLPESFLIVTVRDVGTEK-LKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQ 453
Query: 389 ALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVA-LLPNMTQLYMQMVL-AL 446
L + N L C VPA+ + C+ L L D G+SVA +T L+ V L
Sbjct: 454 GLRAIMNNRELLDQCQVPAVGSLICVALQ--LQD-VVGESVAPFNQTLTGLHAAFVFHQL 510
Query: 447 SPPGHLPTSSLLD-------LGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCV 499
+P G + L+ +A+ G+ K +F D+ + +L +
Sbjct: 511 TPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALF-HMNI 569
Query: 500 CTGPGHQQTGYAFTHLSLQEFLAAL-HLMASPKVNKDTLTQYVTLHSRWVQRTKARLGL- 557
H + Y F HLSLQ+F AAL +++ ++ YV R ++ +A +
Sbjct: 570 LLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGFHIH 629
Query: 558 SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQV-LKKLATRKLTGPKVVELC 616
S + FL GL S R L L G +G KQ + V L T ++
Sbjct: 630 SLWMKRFLFGLVSEDVRRPLEVLL-GCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAF 688
Query: 617 HCVDETQEPELASLTAQSL-PYQLPFHNFPLTCTDLATLTNILEHRE--APIHLDFDGCP 673
HC+ ETQ+ E L S LP + DL + L+H I +D G
Sbjct: 689 HCLFETQDKEFVRLALNSFQEVWLPINQ----NLDLIASSFCLQHCPYLRKIRVDVKGIF 744
Query: 674 LEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISH 733
EA + L + + + E L T L+ L L S +T R +
Sbjct: 745 PRDESAEAC----PVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKT 800
Query: 734 LVKAL--PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVS--TLLC 789
L L P C +++ + FR+ Q++ V ++ ++ LR L+L + + C
Sbjct: 801 LCAKLRHPTC-KIQTLMFRNAQITPG-VQHLWRIVMANRNLRSLNLGGTHLKEEDVRMAC 858
Query: 790 LARVAVTC--PTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTL 847
A C ++R+ +L TT+ ++ L + +G S L
Sbjct: 859 EALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDAL 918
Query: 848 RLQKCQLQ----------VHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQL 897
R+ +C LQ ++L + L L + LS N L +EG L+ +
Sbjct: 919 RVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLP 978
Query: 898 HIA-RKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQE 956
H + ++L L+ L AG C A++ H+SL + P E G +
Sbjct: 979 HCSLQRLMLNQCHLDTAG--CGFLALALMGNSWLTHLSL---------SMNPVEDNGVK- 1026
Query: 957 RAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNAL 1016
L+ ++ E + + L C L E L + S HL LD + NAL
Sbjct: 1027 -------LLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHL--KSLDLTDNAL 1077
Query: 1017 GDEGAARLAQ-LLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
GD G A L + L L L L GL+ D L S + L L++
Sbjct: 1078 GDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
Score = 77.0 bits (188), Expect = 2e-13
Identities = 94/334 (28%), Positives = 148/334 (44%), Gaps = 11/334 (3%)
Query: 1488 SLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALE 1547
S+L + L+ L SS ++ + L + L H + + N G + L R +
Sbjct: 775 SMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVM 834
Query: 1548 GKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCL-QSLRLNRNSIGDVGCCHLSEALRAAT 1606
L+ L+L L + + L CL +SLRL+ + +S+ L +
Sbjct: 835 ANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSP 894
Query: 1607 SLEELDLSHNQIGDAGVQHLATIL-PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLE 1665
SL+ L L+ N++ D GV L+ L L+K+ L I++ G LA +LV R L
Sbjct: 895 SLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLT 954
Query: 1666 ELMLGCNALGDP--TALGLAQELPQ-HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEIS 1722
L L N+LG+ L + LP L+ L L HL G LA AL G+ L +S
Sbjct: 955 HLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLS 1014
Query: 1723 LAENNLA-GGVLRFC--MELPL--LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSW 1777
L+ N + GV C M P L+ ++LV C + + L+ + L+ + L+
Sbjct: 1015 LSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTD 1074
Query: 1778 NLLGDEAAAELAQVLPQMGR-LKRVDLEKNQITA 1810
N LGD A L + L Q L R+ L+ +T+
Sbjct: 1075 NALGDGGVAALCEGLKQKNSVLARLGLKACGLTS 1108
Score = 75.5 bits (184), Expect = 5e-13
Identities = 81/284 (28%), Positives = 124/284 (43%), Gaps = 19/284 (6%)
Query: 1439 ALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKT 1498
+LRL C L L + Q++ T L+ LSL+ + D L +L +S L+
Sbjct: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVT--DQGVMPLSDALRVSQCALQK 927
Query: 1499 FRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALE-GKWMLKRLDL 1557
L ++ G LAS L L L LSNN EG L R++ L+RL L
Sbjct: 928 LILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLML 987
Query: 1558 SHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALR-AATSLEELDLSHN 1616
+ L+++ L L + L L L+ N + D G L E +R + L++L+L
Sbjct: 988 NQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKC 1047
Query: 1617 QIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESL-----VLCRRLEELMLGC 1671
+ A + L+ ++ L+ +DL+ N++ G L E L VL R LG
Sbjct: 1048 HLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLAR------LGL 1101
Query: 1672 NALGDPT----ALGLAQELPQHLRVLHLPFSHLGPGGALSLAQA 1711
A G + AL LA +HL L+L ++ P G + L A
Sbjct: 1102 KACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSA 1145
Score = 37.0 bits (84), Expect = 0.18
Identities = 40/144 (27%), Positives = 60/144 (41%), Gaps = 16/144 (11%)
Query: 1709 AQALDGSPHLEEISLAENNLA----GG-------VLRFCMELP----LLRQIDLVSCKID 1753
AQ G HL I +A NL GG V C L LL + L C +
Sbjct: 820 AQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLT 879
Query: 1754 NQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLP-QMGRLKRVDLEKNQITALG 1812
+ ++ T+ P+L+ + L+ N + D+ L+ L L+++ LE ITA G
Sbjct: 880 HACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATG 939
Query: 1813 AWLLAEGLAQGSSIQVIRLWNNPI 1836
LA L S+ + L NN +
Sbjct: 940 CQSLASALVSNRSLTHLCLSNNSL 963
Score = 36.2 bits (82), Expect = 0.31
Identities = 79/321 (24%), Positives = 122/321 (38%), Gaps = 38/321 (11%)
Query: 1106 RCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQL 1165
+C+ SL L C L ++ L P L L+ ++DQ + L D L ++ Q
Sbjct: 865 KCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDAL-RVSQC 923
Query: 1166 SL--LQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRS--NEEEEGVCCG- 1220
+L L L G++ LA+ L V RSL H L S NE +C
Sbjct: 924 ALQKLILEDCGITATGCQSLASAL--------VSNRSLTHLCLSNNSLGNEGVNLLCRSM 975
Query: 1221 RFTGCS-----LSQEHVES-----LCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQV 1270
R CS L+Q H+++ L L L+ + LS N + D+G++ L E + +
Sbjct: 976 RLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMRE- 1034
Query: 1271 PISGLLDLSHNSISQESALYLLETLPSCPRVR----------EASVNLGSEQSFRIHFSR 1320
P L DL +A E+L SC R + ++ G + +
Sbjct: 1035 PSCHLQDLELVKCHLTAA--CCESL-SCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQ 1091
Query: 1321 EDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAG 1380
++ L L C + L+ LS + LT L L Q K + L S P
Sbjct: 1092 KNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTS 1151
Query: 1381 LFSLRVQEPWADRARVLSLLE 1401
+ W ++ LLE
Sbjct: 1152 NLQIIGLWKWQYPVQIRKLLE 1172
Score = 35.8 bits (81), Expect = 0.40
Identities = 74/303 (24%), Positives = 117/303 (38%), Gaps = 52/303 (17%)
Query: 974 LSSRRMRLTHCG---LQEKHLEQLCKALGG-SCHLGHLHLDFSGNALGDEGAARLAQLLP 1029
+++R +R + G L+E+ + C+AL C L L LD G L +++Q+L
Sbjct: 834 MANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCG--LTHACYLKISQILT 891
Query: 1030 GLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATG 1089
+L+SL+L+ N ++ V+ L Q Q ++L + ATG
Sbjct: 892 TSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCAL--------QKLILE----DCGITATG 939
Query: 1090 --SLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEF 1146
SL + + L LCLS L + LC +++ L+ L L+
Sbjct: 940 CQSLASALVSNRSL--------THLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCH 991
Query: 1147 LSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATL 1206
L L L L+ L LS + LL + R L+ L
Sbjct: 992 LDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVM----REPSCHLQDLELVKC 1047
Query: 1207 HFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLEC 1266
H + CC ESL ++S+ + L +DL+ N LGD G+ L E
Sbjct: 1048 HLTA------ACC-------------ESLSCVISRSRHLKSLDLTDNALGDGGVAALCEG 1088
Query: 1267 LPQ 1269
L Q
Sbjct: 1089 LKQ 1091
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 97.4 bits (241), Expect = 1e-19
Identities = 179/740 (24%), Positives = 277/740 (37%), Gaps = 92/740 (12%)
Query: 225 VLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLFDLYL 282
V G AG+GKT LA ++ WA G L + F LF R+++L+T+ L DL +
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQ-----RSLGDLIM 277
Query: 283 SPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLT----------LFSHLC 332
S D + + + ++L + DG DE LQ + GP+ T L S L
Sbjct: 278 SCCPDPNPPIHKIVRKPSRILFLMDGFDE-LQGAFDEHIGPLCTDWQKAERGDILLSSLI 336
Query: 333 NGTLLPGCRVMATSRPGKLPAC--LPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGAL 390
LLP ++ T+RP L L V +LGF + +EY +FS + A
Sbjct: 337 RKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAF 396
Query: 391 VELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLA--LSP 448
+Q N L ++C +P +C + C L + G+S+A T L+ L P
Sbjct: 397 SLIQENEVLFTMCFIPLVCWIVCTGLKQQMES---GKSLAQTSKTTTAVYVFFLSSLLQP 453
Query: 449 PG----HLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPG 504
G H + L L +A G+ K++F D+ + A S +
Sbjct: 454 RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQ-KADVSAFLRMNLFQKEV 512
Query: 505 HQQTGYAFTHLSLQEFLAAL-HLMASPKVNKDTLT-QYVTLHSRWV-----QRTKARLGL 557
+ Y+F H++ QEF AA+ +L+ K + + + L SR V K G
Sbjct: 513 DCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGY 572
Query: 558 SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK----KLATRKL-TGPKV 612
+ FL GL + +L + C ++Q +++LK K +KL P
Sbjct: 573 LIFVVRFLFGLVNQERTSYL----EKKLSCKISQQIR-LELLKWIEVKAKAKKLQIQPSQ 627
Query: 613 VELCHCVDETQEPELASLTAQSLP------YQLPFHNFPLTCTD---------LATLTNI 657
+EL +C+ E QE + P H C + L L N+
Sbjct: 628 LELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNM 687
Query: 658 LEHREAP----IHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTM 713
+ E HLD C L P A G + + +F L L T
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVL-PSSSHAACSHGLVNS------HLTSSFCRGLFSVLSTS 740
Query: 714 GRLQMLGLAGSKITARGISHLVKAL--PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPR 771
L L L+ + + G+ L + L P C ++ + LS + +I VL +
Sbjct: 741 QSLTELDLSDNSLGDPGMRVLCETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 772 LRKLDLSSNSI--CVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPD 829
L +LDLS N++ LLC+ + C ++ S + + Q
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 830 LQESDGQRKGAQSRSL-------------TLRLQKCQLQVHDAEALIALLQEGPHLEEVD 876
L G G + L L L C L H L LL L ++
Sbjct: 860 LY-LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 918
Query: 877 LSGNQLEDEGCRLMAEAASQ 896
L N L D G + E Q
Sbjct: 919 LGNNDLGDLGVMMFCEVLKQ 938
Score = 64.3 bits (155), Expect = 1e-09
Identities = 88/332 (26%), Positives = 138/332 (41%), Gaps = 44/332 (13%)
Query: 1459 METCARLQQLSLSQV-NLCEDDDASSL------LLQSLLLSLSELK-TFRLTSSCVSTEG 1510
+E C R++ LSL + N+ ++++ ++Q +L S S + L +S +++
Sbjct: 670 IENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSF 729
Query: 1511 LAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALL 1570
L S L L ELDLS+N + G + L L+ H N
Sbjct: 730 CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQ-----------HPGCN------- 771
Query: 1571 THRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATIL 1630
++ L L R + C +S L + L ELDLS N +GD G++ L L
Sbjct: 772 ---------IRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGL 822
Query: 1631 PG-LPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQ- 1688
L L+K+ L + ++S L+ L + L L L N LGD L + L
Sbjct: 823 KHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP 882
Query: 1689 --HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAG-GVLRFCMELP----L 1741
L+VL L +L L+ L S L ++SL N+L GV+ FC L L
Sbjct: 883 DCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 942
Query: 1742 LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVI 1773
L+ + L + +T L + P L V+
Sbjct: 943 LQNLGLSEMYFNYETKSALETLQEEKPELTVV 974
Score = 60.5 bits (145), Expect = 2e-08
Identities = 84/302 (27%), Positives = 129/302 (42%), Gaps = 38/302 (12%)
Query: 1513 HLASG--LGHCHHLEELDLS---NNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1567
H+ S + +CH +E L L N +EE + EG+ LD+ +L SS+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEK-----EGR----HLDMVQCVLPSSSH 713
Query: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627
A +H L S C L L + SL ELDLS N +GD G++ L
Sbjct: 714 AACSHGLVNSHLTSSF-----------CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLC 762
Query: 1628 TIL--PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGD----PTALG 1681
L PG +R++ L +S ++ L ++L EL L NALGD +G
Sbjct: 763 ETLQHPGC-NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVG 821
Query: 1682 LAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPL 1741
L + L +L+ L L S L +L+ L + +L + L N L ++ E L
Sbjct: 822 L-KHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
Query: 1742 -----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
L+ ++L +C + + L++ TS +L + L N LGD +VL Q
Sbjct: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
Query: 1797 RL 1798
L
Sbjct: 941 CL 942
Score = 44.7 bits (104), Expect = 9e-04
Identities = 47/182 (25%), Positives = 84/182 (46%), Gaps = 9/182 (4%)
Query: 1664 LEELMLGCNALGDPTALGLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEE 1720
L EL L N+LGDP L + L ++R L L L ++ L + L E
Sbjct: 743 LTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVE 802
Query: 1721 ISLAENNLAG-GVLRFCMELPLL----RQIDLVSCKIDNQTAKLLTSSFTSCPALEVILL 1775
+ L++N L G+ C+ L L +++ LV+ + + L+S ++ L + L
Sbjct: 803 LDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYL 862
Query: 1776 SWNLLGDEAAAELAQ-VLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNN 1834
N LGD+ L + +L +L+ ++L+ +T+ W L+ L S++ + L NN
Sbjct: 863 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 922
Query: 1835 PI 1836
+
Sbjct: 923 DL 924
Score = 40.4 bits (93), Expect = 0.016
Identities = 97/412 (23%), Positives = 144/412 (34%), Gaps = 111/412 (26%)
Query: 1135 PGPLELQLSC-EFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRV 1193
P LEL E + ++ +D P++ + LS S F + N C RV
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIE----INLSTRMDHMVSSFCIEN----CHRV 676
Query: 1194 KKVDLRSLHHATLHFRSNEEEEG----------------VCCGRFTGCSLSQEHVESLCW 1237
+ + L LH+ EE+EG C L+ L
Sbjct: 677 ESLSLGFLHNMPKE-EEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFS 735
Query: 1238 LLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPS 1297
+LS + L+++DLS N LGD G+R L E L P
Sbjct: 736 VLSTSQSLTELDLSDNSLGDPGMRVLCETLQH--------------------------PG 769
Query: 1298 CPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELT 1357
C N+ + L L C E ++ LS + +L EL
Sbjct: 770 C--------NI-----------------RRLWLGRCGLSHECCFDISLVLSSNQKLVELD 804
Query: 1358 LTQCCLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISE 1417
L+ LG I L VG L +L+ + W + L VC A SV + +
Sbjct: 805 LSDNALG--DFGIRLLCVGLKHLLCNLK--KLWLVNS---GLTSVCCSALSSVLSTNQNL 857
Query: 1418 TQ-------------QQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCAR 1464
T + LC L P + + L L +C+L +H + L+ +
Sbjct: 858 THLYLRGNTLGDKGIKLLCEGLLHP----DCKLQVLELDNCNLTSHCCWDLSTLLTSSQS 913
Query: 1465 LQQLSLSQVNL--------CEDDDASSLLLQSLLLSLSELKTFRLTSSCVST 1508
L++LSL +L CE S LLQ+ L LSE+ T S + T
Sbjct: 914 LRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN--LGLSEMYFNYETKSALET 963
Score = 38.1 bits (87), Expect = 0.081
Identities = 62/258 (24%), Positives = 99/258 (38%), Gaps = 33/258 (12%)
Query: 948 PEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHL-EQLCKALGG--SCHL 1004
P+E++ ++ LD + +PS S +H GL HL C+ L S
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVLPS-----SSHAACSH-GLVNSHLTSSFCRGLFSVLSTSQ 741
Query: 1005 GHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSLNLSENGLSLDAVLGLVRCFSTLQWLF 1063
LD S N+LGD G L + L G ++ L L GLS + + S+ Q L
Sbjct: 742 SLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLV 801
Query: 1064 RLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQ-RCIPRSLCLSECPLEPP 1122
LD+S +L DF +G + C + L L L
Sbjct: 802 ELDLS-------------------DNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSV 842
Query: 1123 SLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCL--PQLPQLSLLQLSQTGLSPKSP 1180
+ L + L L L L D+ ++ L + L P +L +L+L L+
Sbjct: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC-KLQVLELDNCNLTSHCC 901
Query: 1181 FLLANTLSLCPRVKKVDL 1198
+ L+ L+ ++K+ L
Sbjct: 902 WDLSTLLTSSQSLRKLSL 919
Score = 32.0 bits (71), Expect = 5.8
Identities = 67/271 (24%), Positives = 96/271 (35%), Gaps = 40/271 (14%)
Query: 1051 GLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIPR 1110
GL ST Q L LD+S S GD R + T P C R
Sbjct: 732 GLFSVLSTSQSLTELDLSDNSL-----GDPGMRVLCETLQHPG-------------CNIR 773
Query: 1111 SLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLP-QLSLLQ 1169
L L C L + L +EL LS L D + L L L L L
Sbjct: 774 RLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLW 833
Query: 1170 LSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCG--------- 1220
L +GL+ L++ LS + + LR + ++ + +C G
Sbjct: 834 LVNSGLTSVCCSALSSVLSTNQNLTHLYLRG------NTLGDKGIKLLCEGLLHPDCKLQ 887
Query: 1221 --RFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQ----VPISG 1274
C+L+ L LL+ + L ++ L N LGD G+ E L Q + G
Sbjct: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
Query: 1275 LLDLSHNSISQESALYLLETLPSCPRVREAS 1305
L ++ N ++ + L E P V E S
Sbjct: 948 LSEMYFNYETKSALETLQEEKPELTVVFEPS 978
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 96.7 bits (239), Expect = 2e-19
Identities = 186/750 (24%), Positives = 293/750 (39%), Gaps = 98/750 (13%)
Query: 225 VLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLFDLYL 282
V G AG+GKT LA ++ WA G L + F LF R+++L+T+ L DL +
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQ-----RSLGDLIM 277
Query: 283 SPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLT----------LFSHLC 332
S D + + + ++L + DG DE LQ + GP+ T L S L
Sbjct: 278 SCCPDPNPPIHKIVRKPSRILFLMDGFDE-LQGAFDEHIGPLCTDWQKAERGDILLSSLI 336
Query: 333 NGTLLPGCRVMATSRPGKLPAC--LPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGAL 390
LLP ++ T+RP L L V +LGF + +EY +FS + A
Sbjct: 337 RKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAF 396
Query: 391 VELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLA--LSP 448
+Q N L ++C +P +C + C L + G+S+A T L+ L P
Sbjct: 397 SLIQENEVLFTMCFIPLVCWIVCTGLKQQMES---GKSLAQTSKTTTAVYVFFLSSLLQP 453
Query: 449 PG----HLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPG 504
G H + L L +A G+ K++F D+ + A S +
Sbjct: 454 RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQ-KADVSAFLRMNLFQKEV 512
Query: 505 HQQTGYAFTHLSLQEFLAAL-HLMASPKVNKDTLT-QYVTLHSRWV-----QRTKARLGL 557
+ Y+F H++ QEF AA+ +L+ K + + + L SR V K G
Sbjct: 513 DCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGY 572
Query: 558 SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK----KLATRKL-TGPKV 612
+ FL GL + +L + C ++Q +++LK K +KL P
Sbjct: 573 LIFVVRFLFGLVNQERTSYL----EKKLSCKISQQIR-LELLKWIEVKAKAKKLQIQPSQ 627
Query: 613 VELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGC 672
+EL +C+ E QE + Q FP +L+T + H+ C
Sbjct: 628 LELFYCLYEMQEEDFV---------QRAMDYFPKIEINLSTRMD---------HMVSSFC 669
Query: 673 PLEPHCPEALVGCGQIENL--SFKSRKCGDAFAEALSRSLPTMGRLQML-GLAGSKITAR 729
H E+L G + N+ + + + + LP+ GL ++
Sbjct: 670 IENCHRVESL-SLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHE 728
Query: 730 GISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPH-LPRLRKLDLSSNSICVSTLL 788
+ L +L E+ DN L D + + L H L L+KL L S C+++
Sbjct: 729 CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLV--SCCLTSAC 786
Query: 789 C--LARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLT 846
C LA V T ++ L E L A L + + Q+ G + LT
Sbjct: 787 CQDLASVLSTSHSLTRLYVGENAL------GDSGVAILCEKAKNPQCNLQKLGLVNSGLT 840
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLS 906
C AL ++L +L + L GN L D+G +L+ E LH KL +
Sbjct: 841 ---SVC------CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL--LHPDCKLQVL 889
Query: 907 DNGLSVAGVHCVLRAVSACWTLAELHISLQ 936
+ HC CW L+ L S Q
Sbjct: 890 ELDNCNLTSHC-------CWDLSTLLTSSQ 912
Score = 65.5 bits (158), Expect = 5e-10
Identities = 85/300 (28%), Positives = 129/300 (43%), Gaps = 34/300 (11%)
Query: 1513 HLASG--LGHCHHLEELDLS---NNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1567
H+ S + +CH +E L L N +EE + EG+ LD+ +L SS+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEK-----EGR----HLDMVQCVLPSSSH 713
Query: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627
A +H L R + C +S L + L ELDLS N +GD G++ L
Sbjct: 714 AACSHGLG-----------RCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 762
Query: 1628 TILPG-LPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL 1686
L L L+K+ L ++SA LA L L L +G NALGD L ++
Sbjct: 763 VGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKA 822
Query: 1687 --PQ-HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPL-- 1741
PQ +L+ L L S L +L+ L + +L + L N L ++ E L
Sbjct: 823 KNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP 882
Query: 1742 ---LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRL 1798
L+ ++L +C + + L++ TS +L + L N LGD +VL Q L
Sbjct: 883 DCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 942
Score = 58.5 bits (140), Expect = 6e-08
Identities = 61/219 (27%), Positives = 90/219 (41%), Gaps = 4/219 (1%)
Query: 1442 LAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRL 1501
L C L + ++ + +L +L LS L D LL L L LK L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNAL--GDFGIRLLCVGLKHLLCNLKKLWL 777
Query: 1502 TSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALM-RALEGKWMLKRLDLSHL 1560
S C+++ LAS L H L L + N + G L +A + L++L L +
Sbjct: 778 VSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNS 837
Query: 1561 LLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA-LRAATSLEELDLSHNQIG 1619
L S + L+ LS L L L N++GD G L E L L+ L+L + +
Sbjct: 838 GLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLT 897
Query: 1620 DAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESL 1658
L+T+L LRK+ L N + G + E L
Sbjct: 898 SHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVL 936
Score = 41.6 bits (96), Expect = 0.007
Identities = 98/413 (23%), Positives = 140/413 (33%), Gaps = 113/413 (27%)
Query: 1135 PGPLELQLSC-EFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRV 1193
P LEL E + ++ +D P++ + LS S F + N C RV
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIE----INLSTRMDHMVSSFCIEN----CHRV 676
Query: 1194 KKVDLRSLHHATLHFRSNEEEEG----------------VCCGRFTGCSLSQEHVESLCW 1237
+ + L LH+ EE+EG C C LS E +
Sbjct: 677 ESLSLGFLHNMPKE-EEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL 735
Query: 1238 LLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPS 1297
+LS + L ++DLS N LGD G+R L
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLL---------------------------------- 761
Query: 1298 CPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELT 1357
C ++ NL K L L C LA+ LS S LT L
Sbjct: 762 CVGLKHLLCNL-----------------KKLWLVSCCLTSACCQDLASVLSTSHSLTRLY 804
Query: 1358 LTQCCLGQKQLAILLSLVGRP-AGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISIS 1416
+ + LG +AIL P L L + L VC A SV + +
Sbjct: 805 VGENALGDSGVAILCEKAKNPQCNLQKLGLVNS--------GLTSVCCSALSSVLSTNQN 856
Query: 1417 ETQ-------------QQLCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCA 1463
T + LC L P + + L L +C+L +H + L+ +
Sbjct: 857 LTHLYLRGNTLGDKGIKLLCEGLLHP----DCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 912
Query: 1464 RLQQLSLSQVNL--------CEDDDASSLLLQSLLLSLSELKTFRLTSSCVST 1508
L++LSL +L CE S LLQ+ L LSE+ T S + T
Sbjct: 913 SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN--LGLSEMYFNYETKSALET 963
Score = 41.2 bits (95), Expect = 0.010
Identities = 54/192 (28%), Positives = 88/192 (45%), Gaps = 13/192 (6%)
Query: 1657 SLVLC--RRLEELMLGCNALGD----PTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQ 1710
SLVL ++L EL L NALGD +GL + L +L+ L L L LA
Sbjct: 734 SLVLSSNQKLVELDLSDNALGDFGIRLLCVGL-KHLLCNLKKLWLVSCCLTSACCQDLAS 792
Query: 1711 ALDGSPHLEEISLAENNLA-GGVLRFCMELPL----LRQIDLVSCKIDNQTAKLLTSSFT 1765
L S L + + EN L GV C + L+++ LV+ + + L+S +
Sbjct: 793 VLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLS 852
Query: 1766 SCPALEVILLSWNLLGDEAAAELAQ-VLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGS 1824
+ L + L N LGD+ L + +L +L+ ++L+ +T+ W L+ L
Sbjct: 853 TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 912
Query: 1825 SIQVIRLWNNPI 1836
S++ + L NN +
Sbjct: 913 SLRKLSLGNNDL 924
Score = 36.6 bits (83), Expect = 0.24
Identities = 61/258 (23%), Positives = 96/258 (37%), Gaps = 23/258 (8%)
Query: 812 FLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPH 871
FL + P E E + L + + + L +C L + +L
Sbjct: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQK 742
Query: 872 LEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDLSDNGLSVAGVHCVLRAVSACWTLAE 930
L E+DLS N L D G RL+ L +KL L V C L + + C LA
Sbjct: 743 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL---------VSCCLTS-ACCQDLAS 792
Query: 931 LHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKH 990
+ +S H + G +++ + + +++ L + GL
Sbjct: 793 V-LSTSHSLTRLYVGENALGDSGV--------AILCEKAKNPQCNLQKLGLVNSGLTSVC 843
Query: 991 LEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQ-LLPGLGALQSLNLSENGLSLDAV 1049
L L + +L HL+L GN LGD+G L + LL LQ L L L+
Sbjct: 844 CSALSSVLSTNQNLTHLYL--RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 901
Query: 1050 LGLVRCFSTLQWLFRLDI 1067
L ++ Q L +L +
Sbjct: 902 WDLSTLLTSSQSLRKLSL 919
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 95.9 bits (237), Expect = 3e-19
Identities = 214/894 (23%), Positives = 338/894 (37%), Gaps = 134/894 (14%)
Query: 209 ISDLFNTRVNKG--PRVTVLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQALFLFEFRQL 264
+ LF+ V G P++ VL G AG+GKTTL + WAEG L F+ +F R++
Sbjct: 162 LEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREI 221
Query: 265 NLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPD----- 319
N + + ++L+ + S E + + Y + ++ FD L+ A + P+
Sbjct: 222 NQLKE-RSFAQLISKDWPSTEGPIEEIM-YQPSSLLFIIDSFDELNFAFEE--PEFALCE 277
Query: 320 ---GPGPVLTLFSHLCNGTLLPGCRVMATSR--PGKLPACLPAEAAMVHMLGFDGPRVEE 374
PV L S L +LP ++ T+R K L V +LG EE
Sbjct: 278 DWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREE 337
Query: 375 YVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPN 434
Y+ FF + L++N L S+C VP +C AC CL + G
Sbjct: 338 YIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQM--EKGGDVTLTCQT 395
Query: 435 MTQLYMQMVLALSPP--GHLPT----SSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFG 488
T L+ + +L P G P+ + L L +VA +G+ T +FY ++ L G
Sbjct: 396 TTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYREN----LRRLG 451
Query: 489 ATHSLLTSFC---VCTGPGHQQTGYAFTHLSLQEFLAALHLM--ASPKVNKDTLTQYVTL 543
T S ++SF + + Y FTHL +QEF AA+ M S + + + L
Sbjct: 452 LTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDL 511
Query: 544 HSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAK-QAAVVQVLKKL 602
S +Q T + + FL GL + + L + + K ++ ++Q ++ L
Sbjct: 512 KS-LLQSTSYKDPHLTQMKCFLFGLLN---EDRVKQLERTFNCKMSLKIKSKLLQCMEVL 567
Query: 603 ATRKLTGPKV--VELCHCVDETQEPELASLTAQSLP---------YQLPFHNFPLT-CTD 650
+ ++ +EL HC+ ETQ+ S + P L +F L C
Sbjct: 568 GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIHLLVSSFCLKHCRC 627
Query: 651 LATL----TNILEHREAPIHL---DFDGCPLEPHCPEALVGC----GQIENLSFKSRKCG 699
L T+ T + E + L +DG + HC + L + L
Sbjct: 628 LRTIRLSVTVVFEKKILKTSLPTNTWDGDRI-THCWQDLCSVLHTNEHLRELDLYHSNLD 686
Query: 700 DAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQV 758
+ L L +LQ L L G + +L L + + + + D
Sbjct: 687 KSAMNILHHELRHPNCKLQKL-LLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNG 745
Query: 759 VLNIVEVLPHLP-RLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPP 817
V ++ E L H +L+ L L S C T+ C C + R LIFL
Sbjct: 746 VKSLCEALKHPECKLQTLRLES---CNLTVFC-------CLNISNALIRSQSLIFL---- 791
Query: 818 TETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDL 877
+L ++ G Q LR KC +LE + L
Sbjct: 792 -----------NLSTNNLLDDGVQLLCEALRHPKC------------------YLERLSL 822
Query: 878 SGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVS-ACWTLAELHISLQ 936
L + GC ++ A L L+DN L GV + A+ A TL L +
Sbjct: 823 ESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRC 882
Query: 937 HKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCK 996
H T + + +L + +L S L L LQ+ ++ LC
Sbjct: 883 HFTSL---------------SSEYLSTSLLHNKSLTHLD-----LGSNWLQDNGVKLLCD 922
Query: 997 AL-GGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAV 1049
SC+L L L G L + LA ++ L+SL+L N L D V
Sbjct: 923 VFRHPSCNLQDLEL--MGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGV 974
Score = 67.4 bits (163), Expect = 1e-10
Identities = 99/375 (26%), Positives = 161/375 (42%), Gaps = 44/375 (11%)
Query: 1458 LMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASG 1517
++ T L++L L NL D A ++L L +L+ L +G +++
Sbjct: 668 VLHTNEHLRELDLYHSNL--DKSAMNILHHELRHPNCKLQKL-LLKFITFPDGCQDISTS 724
Query: 1518 LGHCHHLEELDLSNNQFDEEGTKALMRAL---EGKWMLKRLD-----------LSHLLLN 1563
L H +L LDL + + G K+L AL E K RL+ +S+ L+
Sbjct: 725 LIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIR 784
Query: 1564 SSTLALL---THRL----SQMTC---------LQSLRLNRNSIGDVGCCHLSEALRAATS 1607
S +L L T+ L Q+ C L+ L L + + GC +LS AL +
Sbjct: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
Query: 1608 LEELDLSHNQIGDAGVQHLATILPGLP-ELRKIDLSGNSISSAGGVQLAESLVLCRRLEE 1666
L L L+ N +GD GV+ ++ L L+ + L +S L+ SL+ + L
Sbjct: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
Query: 1667 LMLGCNALGDPTALGLAQELPQH----LRVLHLPFSHLGPGGALSLAQALDGSPHLEEIS 1722
L LG N L D + L ++ +H L+ L L L L LA + +P+L +
Sbjct: 905 LDLGSNWLQD-NGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLD 963
Query: 1723 LAENNLA-GGVLRFCMELPL----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSW 1777
L N+L GV C L ++++ L C + + + L+S+ L + L+
Sbjct: 964 LGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQ 1023
Query: 1778 NLLGDEAAAELAQVL 1792
N LG E +L +VL
Sbjct: 1024 NTLGYEGIVKLYKVL 1038
Score = 63.9 bits (154), Expect = 1e-09
Identities = 116/458 (25%), Positives = 178/458 (38%), Gaps = 72/458 (15%)
Query: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSE-LKT 1498
L L HC + Q M ++ +N+CE LL+ S L L+T
Sbjct: 580 LELFHCLYETQDKAFISQAMRCFPKVA------INICEK---IHLLVSSFCLKHCRCLRT 630
Query: 1499 FRLTSSCVSTEGLAHLA--------SGLGHC-----------HHLEELDLSNNQFDEEGT 1539
RL+ + V + + + + HC HL ELDL ++ D+
Sbjct: 631 IRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAM 690
Query: 1540 KALMRALE------GKWMLKRL-----------------DLSHLLLNSSTLA-----LLT 1571
L L K +LK + +L HL L S + L
Sbjct: 691 NILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLC 750
Query: 1572 HRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATIL 1630
L C LQ+LRL ++ C ++S AL + SL L+LS N + D GVQ L L
Sbjct: 751 EALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEAL 810
Query: 1631 PGLPE--LRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQ 1688
P+ L ++ L ++ AG L+ +L+ +RL L L N LGD + L + Q
Sbjct: 811 RH-PKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGD-GGVKLMSDALQ 868
Query: 1689 H----LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC--MELPL 1741
H L+ L L H + L+ +L + L + L N L GV C P
Sbjct: 869 HAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPS 928
Query: 1742 --LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG-RL 1798
L+ ++L+ C + N L S + P L + L N L D+ L L +
Sbjct: 929 CNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNI 988
Query: 1799 KRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPI 1836
+R+ LE +T+L L+ L + + L N +
Sbjct: 989 QRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTL 1026
Score = 37.7 bits (86), Expect = 0.11
Identities = 45/176 (25%), Positives = 75/176 (42%), Gaps = 11/176 (6%)
Query: 1439 ALRLAHCDLGA------HHSLLVGQLMETCARLQQLSLSQVNLCED---DDASSLLLQSL 1489
AL+ A C L + H + L + + T + L SL+ ++L + D+ LL
Sbjct: 866 ALQHAQCTLKSLVLRRCHFTSLSSEYLST-SLLHNKSLTHLDLGSNWLQDNGVKLLCDVF 924
Query: 1490 LLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALE-G 1548
L+ L ++ LAS + + +L LDL NN ++G K L AL
Sbjct: 925 RHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYP 984
Query: 1549 KWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRA 1604
++RL L + L S L+ L L + L +N++G G L + L++
Sbjct: 985 NCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKS 1040
Score = 31.6 bits (70), Expect = 7.6
Identities = 87/384 (22%), Positives = 135/384 (35%), Gaps = 86/384 (22%)
Query: 1007 LHLDFSGNALGDEGAARLAQLLPGLGA-LQSLNLSENGLSLDAVLGLVRCFSTLQWLFRL 1065
+HLD G+ +GD G L + L LQ+L L L++ L + Q L L
Sbjct: 732 MHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFL 791
Query: 1066 DISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQ-RCIPRSLCLSECPLEPPSL 1124
++S T +L D R +C L L C L
Sbjct: 792 NLS-------------------TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGC 832
Query: 1125 TRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQ----LPQLSLLQLSQTGLSPK-- 1178
L L L L+ L D ++ + D L L L L + T LS +
Sbjct: 833 EYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYL 892
Query: 1179 SPFLLANTLSLCPRVKKVDLRSLHHATLHFRSN-EEEEGV--CCGRFTGCSLSQEHVESL 1235
S LL N +SL H L SN ++ GV C F S + + +E +
Sbjct: 893 STSLLHN-------------KSLTH--LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELM 937
Query: 1236 -CWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLET 1294
C L + C +DL++ +L + LR LDL +N + + L
Sbjct: 938 GCVLTNAC----CLDLASVILNNPNLRS-------------LDLGNNDLQDDGVKIL--- 977
Query: 1295 LPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLT 1354
C +R + N+ + L L C L++ L + +L
Sbjct: 978 ---CDALRYPNCNI-----------------QRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
Query: 1355 ELTLTQCCLGQKQLAILLSLVGRP 1378
++ LTQ LG + + L ++ P
Sbjct: 1018 KMNLTQNTLGYEGIVKLYKVLKSP 1041
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 91.7 bits (226), Expect = 6e-18
Identities = 161/660 (24%), Positives = 253/660 (38%), Gaps = 89/660 (13%)
Query: 225 VLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLFDLYL 282
V G AG+GKT LA ++ WA G L + F LF R+++L+T+ L DL +
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQ-----RSLGDLIM 277
Query: 283 SPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLT----------LFSHLC 332
S D + + + ++L + DG DE LQ + GP+ T L S L
Sbjct: 278 SCCPDPNPPIHKIVRKPSRILFLMDGFDE-LQGAFDEHIGPLCTDWQKAERGDILLSSLI 336
Query: 333 NGTLLPGCRVMATSRPGKLPAC--LPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGAL 390
LLP ++ T+RP L L V +LGF + +EY +FS + A
Sbjct: 337 RKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAF 396
Query: 391 VELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLA--LSP 448
+Q N L ++C +P +C + C L + G+S+A T L+ L P
Sbjct: 397 SLIQENEVLFTMCFIPLVCWIVCTGLKQQMES---GKSLAQTSKTTTAVYVFFLSSLLQP 453
Query: 449 PG----HLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPG 504
G H + L L +A G+ K++F D+ + A S +
Sbjct: 454 RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQ-KADVSAFLRMNLFQKEV 512
Query: 505 HQQTGYAFTHLSLQEFLAAL-HLMASPKVNKDTLT-QYVTLHSRWV-----QRTKARLGL 557
+ Y+F H++ QEF AA+ +L+ K + + + L SR V K G
Sbjct: 513 DCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGY 572
Query: 558 SDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK----KLATRKL-TGPKV 612
+ FL GL + +L + C ++Q +++LK K +KL P
Sbjct: 573 LIFVVRFLFGLVNQERTSYL----EKKLSCKISQQIR-LELLKWIEVKAKAKKLQIQPSQ 627
Query: 613 VELCHCVDETQEPELASLTAQSLP------YQLPFHNFPLTCTD---------LATLTNI 657
+EL +C+ E QE + P H C + L L N+
Sbjct: 628 LELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNM 687
Query: 658 LEHREAP----IHLDFDGC--PLEPH--CPEALVGCG-----------------QIENLS 692
+ E HLD C P H C L CG ++ L
Sbjct: 688 PKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISLVLSSNQKLVELD 747
Query: 693 FKSRKCGDAFAEALSRSLP-TMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRD 751
GD L L + L+ L L S +T+ S L L L + R
Sbjct: 748 LSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRG 807
Query: 752 NQLSDQVVLNIVEVLPHLP-RLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADL 810
N L D+ + + E L H +L+ L+L + ++ L+ + + ++R L DL
Sbjct: 808 NTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDL 867
Score = 60.8 bits (146), Expect = 1e-08
Identities = 78/275 (28%), Positives = 116/275 (42%), Gaps = 34/275 (12%)
Query: 1513 HLASG--LGHCHHLEELDLS---NNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1567
H+ S + +CH +E L L N +EE + EG+ LD+ +L SS+
Sbjct: 663 HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEK-----EGR----HLDMVQCVLPSSSH 713
Query: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627
A +H L R + C +S L + L ELDLS N +GD G++ L
Sbjct: 714 AACSHGLG-----------RCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 762
Query: 1628 TILPG-LPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQEL 1686
L L L+K+ L + ++S L+ L + L L L N LGD L + L
Sbjct: 763 VGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL 822
Query: 1687 PQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAG-GVLRFCMELP-- 1740
L+VL L +L L+ L S L ++SL N+L GV+ FC L
Sbjct: 823 LHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQ 882
Query: 1741 --LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVI 1773
LL+ + L + +T L + P L V+
Sbjct: 883 SCLLQNLGLSEMYFNYETKSALETLQEEKPELTVV 917
Score = 36.6 bits (83), Expect = 0.24
Identities = 40/146 (27%), Positives = 58/146 (39%), Gaps = 26/146 (17%)
Query: 1135 PGPLELQLSC-EFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRV 1193
P LEL E + ++ +D P++ + LS S F + N C RV
Sbjct: 625 PSQLELFYCLYEMQEEDFVQRAMDYFPKIE----INLSTRMDHMVSSFCIEN----CHRV 676
Query: 1194 KKVDLRSLHHATLHFRSNEEEEG----------------VCCGRFTGCSLSQEHVESLCW 1237
+ + L LH+ EE+EG C C LS E +
Sbjct: 677 ESLSLGFLHNMPKE-EEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSHECCFDISL 735
Query: 1238 LLSKCKDLSQVDLSANLLGDSGLRCL 1263
+LS + L ++DLS N LGD G+R L
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLL 761
Score = 34.7 bits (78), Expect = 0.89
Identities = 32/135 (23%), Positives = 65/135 (48%), Gaps = 6/135 (4%)
Query: 1708 LAQALDGSPHLEEISLAENNLAG-GVLRFCMELPLL----RQIDLVSCKIDNQTAKLLTS 1762
++ L + L E+ L++N L G+ C+ L L +++ LV+ + + L+S
Sbjct: 733 ISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSS 792
Query: 1763 SFTSCPALEVILLSWNLLGDEAAAELAQ-VLPQMGRLKRVDLEKNQITALGAWLLAEGLA 1821
++ L + L N LGD+ L + +L +L+ ++L+ +T+ W L+ L
Sbjct: 793 VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLT 852
Query: 1822 QGSSIQVIRLWNNPI 1836
S++ + L NN +
Sbjct: 853 SSQSLRKLSLGNNDL 867
Score = 34.7 bits (78), Expect = 0.89
Identities = 45/153 (29%), Positives = 69/153 (45%), Gaps = 12/153 (7%)
Query: 1657 SLVLC--RRLEELMLGCNALGD----PTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQ 1710
SLVL ++L EL L NALGD +GL + L +L+ L L S L +L+
Sbjct: 734 SLVLSSNQKLVELDLSDNALGDFGIRLLCVGL-KHLLCNLKKLWLVNSGLTSVCCSALSS 792
Query: 1711 ALDGSPHLEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFT 1765
L + +L + L N L ++ E L L+ ++L +C + + L++ T
Sbjct: 793 VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLT 852
Query: 1766 SCPALEVILLSWNLLGDEAAAELAQVLPQMGRL 1798
S +L + L N LGD +VL Q L
Sbjct: 853 SSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 885
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 91.3 bits (225), Expect = 8e-18
Identities = 95/369 (25%), Positives = 158/369 (42%), Gaps = 40/369 (10%)
Query: 180 ILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNT--RVNKGPRVTVLLGKAGMGKTTL 237
+L A S ++PE ++ ++ V++ LF++ + + P + VL G AG GKTTL
Sbjct: 124 VLLVAKPSSESPE-SLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTL 182
Query: 238 AHRLCQKWAEGHL--NCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYL 295
A ++ WA G L F +F +++ L+ +LLF D+ +
Sbjct: 183 ARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKL-EQLLFWCC----GDNQAPVTEI 237
Query: 296 EKNADQVLLIFDGLDEALQP----MGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKL 351
+ +++L I DG DE +P + G P +L L LP C ++ T+RP L
Sbjct: 238 LRQPERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLAL 297
Query: 352 PACLPA--EAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALC 409
P +A VH+LGF Y + +F+ + + A +Q N L C VP +C
Sbjct: 298 RNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGIC 357
Query: 410 QVACLCLHHLLPDHAPGQSVALLP-NMTQLYMQMVLALSPPGHLPTSS-------LLDLG 461
V C L + G+ V P N T ++M V PP S L L
Sbjct: 358 WVVCSWLQGQM---ERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLC 414
Query: 462 EVALRGLETGKVIFYAKDI------APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHL 515
+A G++ + +F ++ P L AF +++ + + Y+F H+
Sbjct: 415 SLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAI-------KKFYSFRHI 467
Query: 516 SLQEFLAAL 524
S Q+F A+
Sbjct: 468 SFQDFFHAM 476
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 90.9 bits (224), Expect = 1e-17
Identities = 93/345 (26%), Positives = 152/345 (44%), Gaps = 34/345 (9%)
Query: 199 VKVEDGADVSISDLFNTRVN-KGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQA 255
V+ G + I DLF ++ + PR+ +L G AG+GK+TLA ++ + W G L + FQ
Sbjct: 304 VEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQH 363
Query: 256 LFLFEFRQLNLITRFLTPSELL-FDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDE--- 311
+F F R+L ++ ++ +EL+ D +P + + +++L I DG+DE
Sbjct: 364 VFYFSCREL-AQSKVVSLAELIGKDGTATP-----APIRQILSRPERLLFILDGVDEPGW 417
Query: 312 ALQPMGPD------GPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPA--EAAMVH 363
LQ + P P L L T+LP + T+R L +P+ +A V
Sbjct: 418 VLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVE 477
Query: 364 MLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDH 423
+LGF +EY +F+ + A +++N L +LC VP + +AC C L+
Sbjct: 478 VLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTC---LMQQM 534
Query: 424 APGQSVALLPNMTQL----YMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKD 479
+ + L T Y+ L P G L DL +A G+ K +F D
Sbjct: 535 KRKEKLTLTSKTTTTLCLHYLAQALQAQPLG----PQLRDLCSLAAEGIWQKKTLFSPDD 590
Query: 480 IAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAAL 524
+ + + L + P Y+F HL QEF AA+
Sbjct: 591 LRKHGLDGAIISTFLKMGILQEHP--IPLSYSFIHLCFQEFFAAM 633
Score = 53.5 bits (127), Expect = 2e-06
Identities = 63/223 (28%), Positives = 89/223 (39%), Gaps = 36/223 (16%)
Query: 1552 LKRLDLSHLLLNSSTLALLTHRLSQMTCL-QSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
LK LDLS L+ S + L L + CL ++LRL + C L+ LRA +L E
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1611 LDLSHNQIGDAGVQH-----------------------------LATILPGLPELRKIDL 1641
LDLS N + DAG +H LA++L P L+++DL
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1642 SGNSISSAGGVQLAESL--VLCRRLEELMLGCNALGD---PTALGLAQELPQHLRVLHLP 1696
N++ G L E L C +L L L L D L QE PQ L
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPAC-KLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRK 988
Query: 1697 FSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMEL 1739
S + P L + + + L+ L A V + ++L
Sbjct: 989 PSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKL 1031
Score = 52.8 bits (125), Expect = 3e-06
Identities = 49/149 (32%), Positives = 66/149 (44%), Gaps = 2/149 (1%)
Query: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHL-EELDLSNNQFDEEG 1538
DA +L S+L LK L+ + +S + L L L E L L+ E
Sbjct: 794 DAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 1539 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCH 1597
K L L L LDLS +L + L RL Q +C LQ L+L + C
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 1598 LSEALRAATSLEELDLSHNQIGDAGVQHL 1626
L+ L A+ SL+ELDL N + D GV+ L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLL 942
Score = 45.4 bits (106), Expect = 5e-04
Identities = 64/234 (27%), Positives = 94/234 (40%), Gaps = 53/234 (22%)
Query: 1618 IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDP 1677
+ DA Q L ++L L+++DLSGNS+S + L C L P
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL----------------CKTLRRP 835
Query: 1678 TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L L L L L LA L + L E+ L+ N L G C
Sbjct: 836 RCL---------LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLC 886
Query: 1737 MELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
L RQ SCK+ Q +L++ TS + +LA VL
Sbjct: 887 QRL---RQ---PSCKL--QRLQLVSCGLTS----------------DCCQDLASVLSASP 922
Query: 1797 RLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLW--NNPIPCDMAQHLKSQE 1848
LK +DL++N + +G LL EGL + + ++IRL + +M Q L++ E
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGL-RHPACKLIRLGLDQTTLSDEMRQELRALE 975
Score = 43.5 bits (101), Expect = 0.002
Identities = 49/161 (30%), Positives = 73/161 (45%), Gaps = 16/161 (9%)
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL--LC--LARVAVTCPTVRM 802
V FR ++D + VL L++LDLS NS+ S + LC L R T+R+
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 803 ----LQAREA-DLIFLLSPPTETTAELQRAPDLQESDGQRKGAQS------RSLTLRLQK 851
L A + DL F L +T EL + ++ G + Q + L+L
Sbjct: 845 AGCGLTAEDCKDLAFGLRA-NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS 903
Query: 852 CQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAE 892
C L + L ++L P L+E+DL N L+D G RL+ E
Sbjct: 904 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 37.0 bits (84), Expect = 0.18
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 1104 RQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLP 1163
R RC+ +L L+ C L L L+ EL LS L+D + L L Q
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 1164 -QLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
+L LQL GL+ LA+ LS P +K++DL+
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
Score = 37.0 bits (84), Expect = 0.18
Identities = 34/107 (31%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Query: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTF 1499
LRLA C L A + + L +L LS N+ D A L Q L +L+
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLS-FNVLTDAGAKHLC-QRLRQPSCKLQRL 899
Query: 1500 RLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRAL 1546
+L S ++++ LAS L L+ELDL N D+ G + L L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL 946
Score = 36.6 bits (83), Expect = 0.24
Identities = 35/129 (27%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 1182 LLANTLSLCPRVKKVDL--RSLHHATLHFRSNEEEEGVCCG---RFTGCSLSQEHVESLC 1236
+L + L + +K++DL SL H+ + C R GC L+ E + L
Sbjct: 799 ILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLA 858
Query: 1237 WLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL--LDLSHNSISQESALYLLET 1294
+ L + L+++DLS N+L D+G + L + L Q P L L L ++ + L
Sbjct: 859 FGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ-PSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1295 LPSCPRVRE 1303
L + P ++E
Sbjct: 918 LSASPSLKE 926
Score = 33.9 bits (76), Expect = 1.5
Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 846 TLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLD 904
TLRL C L D + L L+ L E+DLS N L D G + + + Q ++L
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 905 LSDNGLSVAGVHCVLRAVSACWTLAELHI 933
L GL+ + +SA +L EL +
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDL 929
Score = 33.9 bits (76), Expect = 1.5
Identities = 31/90 (34%), Positives = 37/90 (41%), Gaps = 3/90 (3%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL + + L L + L L L F N L D GA L Q L LQ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSF--NVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 1038 NLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
L GL+ D L S L LD+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDL 929
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 90.9 bits (224), Expect = 1e-17
Identities = 93/345 (26%), Positives = 152/345 (44%), Gaps = 34/345 (9%)
Query: 199 VKVEDGADVSISDLFNTRVN-KGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQA 255
V+ G + I DLF ++ + PR+ +L G AG+GK+TLA ++ + W G L + FQ
Sbjct: 304 VEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQH 363
Query: 256 LFLFEFRQLNLITRFLTPSELL-FDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDE--- 311
+F F R+L ++ ++ +EL+ D +P + + +++L I DG+DE
Sbjct: 364 VFYFSCREL-AQSKVVSLAELIGKDGTATP-----APIRQILSRPERLLFILDGVDEPGW 417
Query: 312 ALQPMGPD------GPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPA--EAAMVH 363
LQ + P P L L T+LP + T+R L +P+ +A V
Sbjct: 418 VLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVE 477
Query: 364 MLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDH 423
+LGF +EY +F+ + A +++N L +LC VP + +AC C L+
Sbjct: 478 VLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTC---LMQQM 534
Query: 424 APGQSVALLPNMTQL----YMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKD 479
+ + L T Y+ L P G L DL +A G+ K +F D
Sbjct: 535 KRKEKLTLTSKTTTTLCLHYLAQALQAQPLG----PQLRDLCSLAAEGIWQKKTLFSPDD 590
Query: 480 IAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAAL 524
+ + + L + P Y+F HL QEF AA+
Sbjct: 591 LRKHGLDGAIISTFLKMGILQEHP--IPLSYSFIHLCFQEFFAAM 633
Score = 52.8 bits (125), Expect = 3e-06
Identities = 49/149 (32%), Positives = 66/149 (44%), Gaps = 2/149 (1%)
Query: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHL-EELDLSNNQFDEEG 1538
DA +L S+L LK L+ + +S + L L L E L L+ E
Sbjct: 794 DAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 1539 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCH 1597
K L L L LDLS +L + L RL Q +C LQ L+L + C
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 1598 LSEALRAATSLEELDLSHNQIGDAGVQHL 1626
L+ L A+ SL+ELDL N + D GV+ L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLL 942
Score = 51.6 bits (122), Expect = 7e-06
Identities = 43/137 (31%), Positives = 60/137 (43%), Gaps = 30/137 (21%)
Query: 1552 LKRLDLSHLLLNSSTLALLTHRLSQMTCL-QSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
LK LDLS L+ S + L L + CL ++LRL + C L+ LRA +L E
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1611 LDLSHNQIGDAGVQH-----------------------------LATILPGLPELRKIDL 1641
LDLS N + DAG +H LA++L P L+++DL
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1642 SGNSISSAGGVQLAESL 1658
N++ G L E L
Sbjct: 930 QQNNLDDVGVRLLCEGL 946
Score = 44.3 bits (103), Expect = 0.001
Identities = 60/215 (27%), Positives = 86/215 (40%), Gaps = 51/215 (23%)
Query: 1618 IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDP 1677
+ DA Q L ++L L+++DLSGNS+S + L C L P
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL----------------CKTLRRP 835
Query: 1678 TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L L L L L LA L + L E+ L+ N L G C
Sbjct: 836 RCL---------LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLC 886
Query: 1737 MELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
L RQ SCK+ Q +L++ TS + +LA VL
Sbjct: 887 QRL---RQ---PSCKL--QRLQLVSCGLTS----------------DCCQDLASVLSASP 922
Query: 1797 RLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRL 1831
LK +DL++N + +G LL EGL + + ++IRL
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGL-RHPACKLIRL 956
Score = 43.5 bits (101), Expect = 0.002
Identities = 49/161 (30%), Positives = 73/161 (45%), Gaps = 16/161 (9%)
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL--LC--LARVAVTCPTVRM 802
V FR ++D + VL L++LDLS NS+ S + LC L R T+R+
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 803 ----LQAREA-DLIFLLSPPTETTAELQRAPDLQESDGQRKGAQS------RSLTLRLQK 851
L A + DL F L +T EL + ++ G + Q + L+L
Sbjct: 845 AGCGLTAEDCKDLAFGLRA-NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS 903
Query: 852 CQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAE 892
C L + L ++L P L+E+DL N L+D G RL+ E
Sbjct: 904 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 37.4 bits (85), Expect = 0.14
Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 13/176 (7%)
Query: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTF 1499
LRLA C L A + + L +L LS N+ D A L Q L +L+
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLS-FNVLTDAGAKHLC-QRLRQPSCKLQRL 899
Query: 1500 RLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSH 1559
+L S ++++ LAS L L+ELDL N D+ G + L L K + L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP-ACKLIRLGK 958
Query: 1560 LLLNSSTLALLTHRLSQMTCLQSLRLNRNSIG-DVGCCHLSEALRAATSLEELDLS 1614
+ + T L T +S T L R +G + H+++A +L+ LD+S
Sbjct: 959 PSVMTPTEGLDTGEMSNSTS----SLKRQRLGSERAASHVAQA-----NLKLLDVS 1005
Score = 37.0 bits (84), Expect = 0.18
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 1104 RQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLP 1163
R RC+ +L L+ C L L L+ EL LS L+D + L L Q
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 1164 -QLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
+L LQL GL+ LA+ LS P +K++DL+
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
Score = 36.6 bits (83), Expect = 0.24
Identities = 35/129 (27%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 1182 LLANTLSLCPRVKKVDL--RSLHHATLHFRSNEEEEGVCCG---RFTGCSLSQEHVESLC 1236
+L + L + +K++DL SL H+ + C R GC L+ E + L
Sbjct: 799 ILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLA 858
Query: 1237 WLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL--LDLSHNSISQESALYLLET 1294
+ L + L+++DLS N+L D+G + L + L Q P L L L ++ + L
Sbjct: 859 FGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ-PSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1295 LPSCPRVRE 1303
L + P ++E
Sbjct: 918 LSASPSLKE 926
Score = 33.9 bits (76), Expect = 1.5
Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 846 TLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLD 904
TLRL C L D + L L+ L E+DLS N L D G + + + Q ++L
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 905 LSDNGLSVAGVHCVLRAVSACWTLAELHI 933
L GL+ + +SA +L EL +
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDL 929
Score = 33.9 bits (76), Expect = 1.5
Identities = 31/90 (34%), Positives = 37/90 (41%), Gaps = 3/90 (3%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL + + L L + L L L F N L D GA L Q L LQ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSF--NVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 1038 NLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
L GL+ D L S L LD+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Score = 31.6 bits (70), Expect = 7.6
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 1/72 (1%)
Query: 715 RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRK 774
+LQ L L +T+ L L P LKE+ + N L D V + E L H P +
Sbjct: 895 KLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH-PACKL 953
Query: 775 LDLSSNSICVST 786
+ L S+ T
Sbjct: 954 IRLGKPSVMTPT 965
Score = 31.2 bits (69), Expect = 9.9
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 1/63 (1%)
Query: 1221 RFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSH 1280
+ C L+ + + L +LS L ++DL N L D G+R L E L + P L+ L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL-RHPACKLIRLGK 958
Query: 1281 NSI 1283
S+
Sbjct: 959 PSV 961
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 90.9 bits (224), Expect = 1e-17
Identities = 93/345 (26%), Positives = 152/345 (44%), Gaps = 34/345 (9%)
Query: 199 VKVEDGADVSISDLFNTRVN-KGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQA 255
V+ G + I DLF ++ + PR+ +L G AG+GK+TLA ++ + W G L + FQ
Sbjct: 304 VEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQH 363
Query: 256 LFLFEFRQLNLITRFLTPSELL-FDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDE--- 311
+F F R+L ++ ++ +EL+ D +P + + +++L I DG+DE
Sbjct: 364 VFYFSCREL-AQSKVVSLAELIGKDGTATP-----APIRQILSRPERLLFILDGVDEPGW 417
Query: 312 ALQPMGPD------GPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPA--EAAMVH 363
LQ + P P L L T+LP + T+R L +P+ +A V
Sbjct: 418 VLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVE 477
Query: 364 MLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDH 423
+LGF +EY +F+ + A +++N L +LC VP + +AC C L+
Sbjct: 478 VLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTC---LMQQM 534
Query: 424 APGQSVALLPNMTQL----YMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKD 479
+ + L T Y+ L P G L DL +A G+ K +F D
Sbjct: 535 KRKEKLTLTSKTTTTLCLHYLAQALQAQPLG----PQLRDLCSLAAEGIWQKKTLFSPDD 590
Query: 480 IAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAAL 524
+ + + L + P Y+F HL QEF AA+
Sbjct: 591 LRKHGLDGAIISTFLKMGILQEHP--IPLSYSFIHLCFQEFFAAM 633
Score = 53.5 bits (127), Expect = 2e-06
Identities = 63/223 (28%), Positives = 89/223 (39%), Gaps = 36/223 (16%)
Query: 1552 LKRLDLSHLLLNSSTLALLTHRLSQMTCL-QSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
LK LDLS L+ S + L L + CL ++LRL + C L+ LRA +L E
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1611 LDLSHNQIGDAGVQH-----------------------------LATILPGLPELRKIDL 1641
LDLS N + DAG +H LA++L P L+++DL
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1642 SGNSISSAGGVQLAESL--VLCRRLEELMLGCNALGD---PTALGLAQELPQHLRVLHLP 1696
N++ G L E L C +L L L L D L QE PQ L
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPAC-KLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRK 988
Query: 1697 FSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMEL 1739
S + P L + + + L+ L A V + ++L
Sbjct: 989 PSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKL 1031
Score = 52.8 bits (125), Expect = 3e-06
Identities = 49/149 (32%), Positives = 66/149 (44%), Gaps = 2/149 (1%)
Query: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHL-EELDLSNNQFDEEG 1538
DA +L S+L LK L+ + +S + L L L E L L+ E
Sbjct: 794 DAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 1539 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCH 1597
K L L L LDLS +L + L RL Q +C LQ L+L + C
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 1598 LSEALRAATSLEELDLSHNQIGDAGVQHL 1626
L+ L A+ SL+ELDL N + D GV+ L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLL 942
Score = 45.4 bits (106), Expect = 5e-04
Identities = 64/234 (27%), Positives = 94/234 (40%), Gaps = 53/234 (22%)
Query: 1618 IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDP 1677
+ DA Q L ++L L+++DLSGNS+S + L C L P
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL----------------CKTLRRP 835
Query: 1678 TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L L L L L LA L + L E+ L+ N L G C
Sbjct: 836 RCL---------LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLC 886
Query: 1737 MELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
L RQ SCK+ Q +L++ TS + +LA VL
Sbjct: 887 QRL---RQ---PSCKL--QRLQLVSCGLTS----------------DCCQDLASVLSASP 922
Query: 1797 RLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLW--NNPIPCDMAQHLKSQE 1848
LK +DL++N + +G LL EGL + + ++IRL + +M Q L++ E
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGL-RHPACKLIRLGLDQTTLSDEMRQELRALE 975
Score = 43.5 bits (101), Expect = 0.002
Identities = 49/161 (30%), Positives = 73/161 (45%), Gaps = 16/161 (9%)
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL--LC--LARVAVTCPTVRM 802
V FR ++D + VL L++LDLS NS+ S + LC L R T+R+
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 803 ----LQAREA-DLIFLLSPPTETTAELQRAPDLQESDGQRKGAQS------RSLTLRLQK 851
L A + DL F L +T EL + ++ G + Q + L+L
Sbjct: 845 AGCGLTAEDCKDLAFGLRA-NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS 903
Query: 852 CQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAE 892
C L + L ++L P L+E+DL N L+D G RL+ E
Sbjct: 904 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 37.0 bits (84), Expect = 0.18
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 1104 RQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLP 1163
R RC+ +L L+ C L L L+ EL LS L+D + L L Q
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 1164 -QLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
+L LQL GL+ LA+ LS P +K++DL+
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
Score = 37.0 bits (84), Expect = 0.18
Identities = 34/107 (31%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Query: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTF 1499
LRLA C L A + + L +L LS N+ D A L Q L +L+
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLS-FNVLTDAGAKHLC-QRLRQPSCKLQRL 899
Query: 1500 RLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRAL 1546
+L S ++++ LAS L L+ELDL N D+ G + L L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL 946
Score = 36.6 bits (83), Expect = 0.24
Identities = 35/129 (27%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 1182 LLANTLSLCPRVKKVDL--RSLHHATLHFRSNEEEEGVCCG---RFTGCSLSQEHVESLC 1236
+L + L + +K++DL SL H+ + C R GC L+ E + L
Sbjct: 799 ILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLA 858
Query: 1237 WLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL--LDLSHNSISQESALYLLET 1294
+ L + L+++DLS N+L D+G + L + L Q P L L L ++ + L
Sbjct: 859 FGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ-PSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1295 LPSCPRVRE 1303
L + P ++E
Sbjct: 918 LSASPSLKE 926
Score = 33.9 bits (76), Expect = 1.5
Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 846 TLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLD 904
TLRL C L D + L L+ L E+DLS N L D G + + + Q ++L
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 905 LSDNGLSVAGVHCVLRAVSACWTLAELHI 933
L GL+ + +SA +L EL +
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDL 929
Score = 33.9 bits (76), Expect = 1.5
Identities = 31/90 (34%), Positives = 37/90 (41%), Gaps = 3/90 (3%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL + + L L + L L L F N L D GA L Q L LQ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSF--NVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 1038 NLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
L GL+ D L S L LD+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDL 929
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 90.9 bits (224), Expect = 1e-17
Identities = 93/345 (26%), Positives = 152/345 (44%), Gaps = 34/345 (9%)
Query: 199 VKVEDGADVSISDLFNTRVN-KGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQA 255
V+ G + I DLF ++ + PR+ +L G AG+GK+TLA ++ + W G L + FQ
Sbjct: 304 VEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQH 363
Query: 256 LFLFEFRQLNLITRFLTPSELL-FDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDE--- 311
+F F R+L ++ ++ +EL+ D +P + + +++L I DG+DE
Sbjct: 364 VFYFSCREL-AQSKVVSLAELIGKDGTATP-----APIRQILSRPERLLFILDGVDEPGW 417
Query: 312 ALQPMGPD------GPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPA--EAAMVH 363
LQ + P P L L T+LP + T+R L +P+ +A V
Sbjct: 418 VLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVE 477
Query: 364 MLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDH 423
+LGF +EY +F+ + A +++N L +LC VP + +AC C L+
Sbjct: 478 VLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTC---LMQQM 534
Query: 424 APGQSVALLPNMTQL----YMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKD 479
+ + L T Y+ L P G L DL +A G+ K +F D
Sbjct: 535 KRKEKLTLTSKTTTTLCLHYLAQALQAQPLG----PQLRDLCSLAAEGIWQKKTLFSPDD 590
Query: 480 IAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAAL 524
+ + + L + P Y+F HL QEF AA+
Sbjct: 591 LRKHGLDGAIISTFLKMGILQEHP--IPLSYSFIHLCFQEFFAAM 633
Score = 52.8 bits (125), Expect = 3e-06
Identities = 49/149 (32%), Positives = 66/149 (44%), Gaps = 2/149 (1%)
Query: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHL-EELDLSNNQFDEEG 1538
DA +L S+L LK L+ + +S + L L L E L L+ E
Sbjct: 794 DAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 1539 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCH 1597
K L L L LDLS +L + L RL Q +C LQ L+L + C
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 1598 LSEALRAATSLEELDLSHNQIGDAGVQHL 1626
L+ L A+ SL+ELDL N + D GV+ L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLL 942
Score = 51.6 bits (122), Expect = 7e-06
Identities = 43/137 (31%), Positives = 60/137 (43%), Gaps = 30/137 (21%)
Query: 1552 LKRLDLSHLLLNSSTLALLTHRLSQMTCL-QSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
LK LDLS L+ S + L L + CL ++LRL + C L+ LRA +L E
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1611 LDLSHNQIGDAGVQH-----------------------------LATILPGLPELRKIDL 1641
LDLS N + DAG +H LA++L P L+++DL
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1642 SGNSISSAGGVQLAESL 1658
N++ G L E L
Sbjct: 930 QQNNLDDVGVRLLCEGL 946
Score = 44.3 bits (103), Expect = 0.001
Identities = 60/215 (27%), Positives = 86/215 (40%), Gaps = 51/215 (23%)
Query: 1618 IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDP 1677
+ DA Q L ++L L+++DLSGNS+S + L C L P
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL----------------CKTLRRP 835
Query: 1678 TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L L L L L LA L + L E+ L+ N L G C
Sbjct: 836 RCL---------LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLC 886
Query: 1737 MELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
L RQ SCK+ Q +L++ TS + +LA VL
Sbjct: 887 QRL---RQ---PSCKL--QRLQLVSCGLTS----------------DCCQDLASVLSASP 922
Query: 1797 RLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRL 1831
LK +DL++N + +G LL EGL + + ++IRL
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGL-RHPACKLIRL 956
Score = 43.5 bits (101), Expect = 0.002
Identities = 49/161 (30%), Positives = 73/161 (45%), Gaps = 16/161 (9%)
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL--LC--LARVAVTCPTVRM 802
V FR ++D + VL L++LDLS NS+ S + LC L R T+R+
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 803 ----LQAREA-DLIFLLSPPTETTAELQRAPDLQESDGQRKGAQS------RSLTLRLQK 851
L A + DL F L +T EL + ++ G + Q + L+L
Sbjct: 845 AGCGLTAEDCKDLAFGLRA-NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS 903
Query: 852 CQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAE 892
C L + L ++L P L+E+DL N L+D G RL+ E
Sbjct: 904 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 37.4 bits (85), Expect = 0.14
Identities = 50/176 (28%), Positives = 76/176 (43%), Gaps = 13/176 (7%)
Query: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTF 1499
LRLA C L A + + L +L LS N+ D A L Q L +L+
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLS-FNVLTDAGAKHLC-QRLRQPSCKLQRL 899
Query: 1500 RLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSH 1559
+L S ++++ LAS L L+ELDL N D+ G + L L K + L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP-ACKLIRLGK 958
Query: 1560 LLLNSSTLALLTHRLSQMTCLQSLRLNRNSIG-DVGCCHLSEALRAATSLEELDLS 1614
+ + T L T +S T L R +G + H+++A +L+ LD+S
Sbjct: 959 PSVMTPTEGLDTGEMSNSTS----SLKRQRLGSERAASHVAQA-----NLKLLDVS 1005
Score = 37.0 bits (84), Expect = 0.18
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 1104 RQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLP 1163
R RC+ +L L+ C L L L+ EL LS L+D + L L Q
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 1164 -QLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
+L LQL GL+ LA+ LS P +K++DL+
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
Score = 36.6 bits (83), Expect = 0.24
Identities = 35/129 (27%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 1182 LLANTLSLCPRVKKVDL--RSLHHATLHFRSNEEEEGVCCG---RFTGCSLSQEHVESLC 1236
+L + L + +K++DL SL H+ + C R GC L+ E + L
Sbjct: 799 ILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLA 858
Query: 1237 WLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL--LDLSHNSISQESALYLLET 1294
+ L + L+++DLS N+L D+G + L + L Q P L L L ++ + L
Sbjct: 859 FGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ-PSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1295 LPSCPRVRE 1303
L + P ++E
Sbjct: 918 LSASPSLKE 926
Score = 33.9 bits (76), Expect = 1.5
Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 846 TLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLD 904
TLRL C L D + L L+ L E+DLS N L D G + + + Q ++L
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 905 LSDNGLSVAGVHCVLRAVSACWTLAELHI 933
L GL+ + +SA +L EL +
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDL 929
Score = 33.9 bits (76), Expect = 1.5
Identities = 31/90 (34%), Positives = 37/90 (41%), Gaps = 3/90 (3%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL + + L L + L L L F N L D GA L Q L LQ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSF--NVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 1038 NLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
L GL+ D L S L LD+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Score = 31.6 bits (70), Expect = 7.6
Identities = 22/72 (30%), Positives = 31/72 (43%), Gaps = 1/72 (1%)
Query: 715 RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRK 774
+LQ L L +T+ L L P LKE+ + N L D V + E L H P +
Sbjct: 895 KLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRH-PACKL 953
Query: 775 LDLSSNSICVST 786
+ L S+ T
Sbjct: 954 IRLGKPSVMTPT 965
Score = 31.2 bits (69), Expect = 9.9
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 1/63 (1%)
Query: 1221 RFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLSH 1280
+ C L+ + + L +LS L ++DL N L D G+R L E L + P L+ L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL-RHPACKLIRLGK 958
Query: 1281 NSI 1283
S+
Sbjct: 959 PSV 961
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 90.9 bits (224), Expect = 1e-17
Identities = 93/345 (26%), Positives = 152/345 (44%), Gaps = 34/345 (9%)
Query: 199 VKVEDGADVSISDLFNTRVN-KGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHL--NCFQA 255
V+ G + I DLF ++ + PR+ +L G AG+GK+TLA ++ + W G L + FQ
Sbjct: 304 VEENRGHLIEIRDLFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQH 363
Query: 256 LFLFEFRQLNLITRFLTPSELL-FDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDE--- 311
+F F R+L ++ ++ +EL+ D +P + + +++L I DG+DE
Sbjct: 364 VFYFSCREL-AQSKVVSLAELIGKDGTATP-----APIRQILSRPERLLFILDGVDEPGW 417
Query: 312 ALQPMGPD------GPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPA--EAAMVH 363
LQ + P P L L T+LP + T+R L +P+ +A V
Sbjct: 418 VLQEPSSELCLHWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVE 477
Query: 364 MLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDH 423
+LGF +EY +F+ + A +++N L +LC VP + +AC C L+
Sbjct: 478 VLGFSESSRKEYFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTC---LMQQM 534
Query: 424 APGQSVALLPNMTQL----YMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKD 479
+ + L T Y+ L P G L DL +A G+ K +F D
Sbjct: 535 KRKEKLTLTSKTTTTLCLHYLAQALQAQPLG----PQLRDLCSLAAEGIWQKKTLFSPDD 590
Query: 480 IAPPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAAL 524
+ + + L + P Y+F HL QEF AA+
Sbjct: 591 LRKHGLDGAIISTFLKMGILQEHP--IPLSYSFIHLCFQEFFAAM 633
Score = 53.5 bits (127), Expect = 2e-06
Identities = 63/223 (28%), Positives = 89/223 (39%), Gaps = 36/223 (16%)
Query: 1552 LKRLDLSHLLLNSSTLALLTHRLSQMTCL-QSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
LK LDLS L+ S + L L + CL ++LRL + C L+ LRA +L E
Sbjct: 810 LKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTE 869
Query: 1611 LDLSHNQIGDAGVQH-----------------------------LATILPGLPELRKIDL 1641
LDLS N + DAG +H LA++L P L+++DL
Sbjct: 870 LDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDL 929
Query: 1642 SGNSISSAGGVQLAESL--VLCRRLEELMLGCNALGD---PTALGLAQELPQHLRVLHLP 1696
N++ G L E L C +L L L L D L QE PQ L
Sbjct: 930 QQNNLDDVGVRLLCEGLRHPAC-KLIRLGLDQTTLSDEMRQELRALEQEKPQLLIFSRRK 988
Query: 1697 FSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMEL 1739
S + P L + + + L+ L A V + ++L
Sbjct: 989 PSVMTPTEGLDTGEMSNSTSSLKRQRLGSERAASHVAQANLKL 1031
Score = 52.8 bits (125), Expect = 3e-06
Identities = 49/149 (32%), Positives = 66/149 (44%), Gaps = 2/149 (1%)
Query: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHL-EELDLSNNQFDEEG 1538
DA +L S+L LK L+ + +S + L L L E L L+ E
Sbjct: 794 DAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAED 853
Query: 1539 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCH 1597
K L L L LDLS +L + L RL Q +C LQ L+L + C
Sbjct: 854 CKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQD 913
Query: 1598 LSEALRAATSLEELDLSHNQIGDAGVQHL 1626
L+ L A+ SL+ELDL N + D GV+ L
Sbjct: 914 LASVLSASPSLKELDLQQNNLDDVGVRLL 942
Score = 45.4 bits (106), Expect = 5e-04
Identities = 64/234 (27%), Positives = 94/234 (40%), Gaps = 53/234 (22%)
Query: 1618 IGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDP 1677
+ DA Q L ++L L+++DLSGNS+S + L C L P
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSL----------------CKTLRRP 835
Query: 1678 TALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L L L L L LA L + L E+ L+ N L G C
Sbjct: 836 RCL---------LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLC 886
Query: 1737 MELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMG 1796
L RQ SCK+ Q +L++ TS + +LA VL
Sbjct: 887 QRL---RQ---PSCKL--QRLQLVSCGLTS----------------DCCQDLASVLSASP 922
Query: 1797 RLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLW--NNPIPCDMAQHLKSQE 1848
LK +DL++N + +G LL EGL + + ++IRL + +M Q L++ E
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGL-RHPACKLIRLGLDQTTLSDEMRQELRALE 975
Score = 43.5 bits (101), Expect = 0.002
Identities = 49/161 (30%), Positives = 73/161 (45%), Gaps = 16/161 (9%)
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTL--LC--LARVAVTCPTVRM 802
V FR ++D + VL L++LDLS NS+ S + LC L R T+R+
Sbjct: 785 VLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRL 844
Query: 803 ----LQAREA-DLIFLLSPPTETTAELQRAPDLQESDGQRKGAQS------RSLTLRLQK 851
L A + DL F L +T EL + ++ G + Q + L+L
Sbjct: 845 AGCGLTAEDCKDLAFGLRA-NQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVS 903
Query: 852 CQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAE 892
C L + L ++L P L+E+DL N L+D G RL+ E
Sbjct: 904 CGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 37.0 bits (84), Expect = 0.18
Identities = 32/97 (32%), Positives = 45/97 (46%), Gaps = 1/97 (1%)
Query: 1104 RQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLP 1163
R RC+ +L L+ C L L L+ EL LS L+D + L L Q
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 1164 -QLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
+L LQL GL+ LA+ LS P +K++DL+
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQ 930
Score = 37.0 bits (84), Expect = 0.18
Identities = 34/107 (31%), Positives = 48/107 (44%), Gaps = 2/107 (1%)
Query: 1440 LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTF 1499
LRLA C L A + + L +L LS N+ D A L Q L +L+
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLS-FNVLTDAGAKHLC-QRLRQPSCKLQRL 899
Query: 1500 RLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRAL 1546
+L S ++++ LAS L L+ELDL N D+ G + L L
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGL 946
Score = 36.6 bits (83), Expect = 0.24
Identities = 35/129 (27%), Positives = 60/129 (46%), Gaps = 8/129 (6%)
Query: 1182 LLANTLSLCPRVKKVDL--RSLHHATLHFRSNEEEEGVCCG---RFTGCSLSQEHVESLC 1236
+L + L + +K++DL SL H+ + C R GC L+ E + L
Sbjct: 799 ILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLA 858
Query: 1237 WLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGL--LDLSHNSISQESALYLLET 1294
+ L + L+++DLS N+L D+G + L + L Q P L L L ++ + L
Sbjct: 859 FGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ-PSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1295 LPSCPRVRE 1303
L + P ++E
Sbjct: 918 LSASPSLKE 926
Score = 33.9 bits (76), Expect = 1.5
Identities = 28/89 (31%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 846 TLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLD 904
TLRL C L D + L L+ L E+DLS N L D G + + + Q ++L
Sbjct: 841 TLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQ 900
Query: 905 LSDNGLSVAGVHCVLRAVSACWTLAELHI 933
L GL+ + +SA +L EL +
Sbjct: 901 LVSCGLTSDCCQDLASVLSASPSLKELDL 929
Score = 33.9 bits (76), Expect = 1.5
Identities = 31/90 (34%), Positives = 37/90 (41%), Gaps = 3/90 (3%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL + + L L + L L L F N L D GA L Q L LQ L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSF--NVLTDAGAKHLCQRLRQPSCKLQRL 899
Query: 1038 NLSENGLSLDAVLGLVRCFSTLQWLFRLDI 1067
L GL+ D L S L LD+
Sbjct: 900 QLVSCGLTSDCCQDLASVLSASPSLKELDL 929
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 89.7 bits (221), Expect = 2e-17
Identities = 112/426 (26%), Positives = 173/426 (40%), Gaps = 34/426 (7%)
Query: 1390 WADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVALRLAHCDLG- 1448
WA+ +L +V +TE + L V NP L L +LG
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRV---------NPALAELNLRSNELGD 70
Query: 1449 -AHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
H +L G +C ++Q+LSL C A +L S L +L L+ L+ + +
Sbjct: 71 VGVHCVLQGLQTPSC-KIQKLSLQN---CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLG 126
Query: 1508 TEGLAHLASGL--GHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
GL L GL C LE+L L + L L K K L +S+ +N +
Sbjct: 127 DAGLQLLCEGLLDPQCR-LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEA 185
Query: 1566 TLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
+ +L L C L++L+L + C L + + SL EL L N++GD G
Sbjct: 186 GVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG-- 243
Query: 1625 HLATILPGL----PELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
+A + PGL LR + + I++ G L L L+EL L N LGD A
Sbjct: 244 -MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1681 GLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLA-GGVLRFC 1736
L + L + L L + + L + L E+ ++ N L GV C
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
Query: 1737 MEL----PLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVL 1792
L +LR + L C + + + L ++ + +L + LS N LGD +L + +
Sbjct: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
Query: 1793 PQMGRL 1798
Q G L
Sbjct: 423 RQPGCL 428
Score = 78.2 bits (191), Expect = 7e-14
Identities = 127/505 (25%), Positives = 198/505 (39%), Gaps = 112/505 (22%)
Query: 1140 LQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLR 1199
L + CE LSD LL P L Q +++L GL+ +++ L + P +
Sbjct: 8 LDIQCEELSDARWAELL---PLLQQCQVVRLDDCGLTEARCKDISSALRVNPAL------ 58
Query: 1200 SLHHATLHFRSNE-EEEGVCCG----RFTGCSLSQEHVESLCWLLSKCKDLS-------- 1246
A L+ RSNE + GV C + C + + +++ C + C LS
Sbjct: 59 ----AELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
Query: 1247 --QVDLSANLLGDSGLRCLLECL--PQVPISGLLDLSHNSISQESALYLLETLPSCPRVR 1302
++ LS NLLGD+GL+ L E L PQ + L L + S+S S L L + P +
Sbjct: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL-QLEYCSLSAASCEPLASVLRAKPDFK 173
Query: 1303 EASVNLGSEQSFRIHFSREDQAGKTLRLSECSFRPEHVSRLATGLSKS-LQLTELTLTQC 1361
E +V S D ++E R L GL S QL L L C
Sbjct: 174 ELTV------------SNND-------INEAGVRV-----LCQGLKDSPCQLEALKLESC 209
Query: 1362 CLGQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQ 1421
+ L +V A L L A S + ++ ++E
Sbjct: 210 GVTSDNCRDLCGIVASKASLREL-------------------ALGSNKLGDVGMAE---- 246
Query: 1422 LCVQLEFPRQEENPEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDA 1481
LC L P L + C + A + +++ L++LSL+ L D+
Sbjct: 247 LCPGLLHPSSRLR----TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL--GDEG 300
Query: 1482 SSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKA 1541
+ LL ++LL +L++ + S + +H +S L L EL +SNN+ ++ G +
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
L + L + R+ L L + D C L+
Sbjct: 361 LCQGLGQPGSVLRV---------------------------LWLADCDVSDSSCSSLAAT 393
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHL 1626
L A SL ELDLS+N +GDAG+ L
Sbjct: 394 LLANHSLRELDLSNNCLGDAGILQL 418
Score = 68.9 bits (167), Expect = 4e-11
Identities = 111/428 (25%), Positives = 157/428 (36%), Gaps = 97/428 (22%)
Query: 1483 SLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKAL 1542
SL +QSL + EL R A L L C + + L + E K +
Sbjct: 2 SLDIQSLDIQCEELSDARW----------AELLPLLQQC---QVVRLDDCGLTEARCKDI 48
Query: 1543 MRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEA 1601
AL L L+L L + + L +C +Q L L + GC LS
Sbjct: 49 SSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSST 108
Query: 1602 LRAATSLEELDLSHNQIGDAGVQ-----------------------------HLATILPG 1632
LR +L+EL LS N +GDAG+Q LA++L
Sbjct: 109 LRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRA 168
Query: 1633 LPELRKIDLSGNSISSAGGVQLAESLV-----------------------LC------RR 1663
P+ +++ +S N I+ AG L + L LC
Sbjct: 169 KPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKAS 228
Query: 1664 LEELMLGCNALGDPTALGLAQELP------QHLRVLHLPFSHLGPGGALSLAQALDGSPH 1717
L EL LG N LGD +G+A+ P LR L + + G L + L
Sbjct: 229 LRELALGSNKLGD---VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 1718 LEEISLAENNLAGGVLRFCMELPL-----LRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
L+E+SLA N L R E L L + + SC +S L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRV------DLEKNQITALGAWLLAEGLAQGSSI 1826
+ +S N L D EL Q L Q G + RV D+ + ++L A LLA S+
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA-----NHSL 400
Query: 1827 QVIRLWNN 1834
+ + L NN
Sbjct: 401 RELDLSNN 408
Score = 58.5 bits (140), Expect = 6e-08
Identities = 113/434 (26%), Positives = 156/434 (35%), Gaps = 69/434 (15%)
Query: 979 MRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGA-LQSL 1037
+RL CGL E + + AL + L L+L N LGD G + Q L +Q L
Sbjct: 33 VRLDDCGLTEARCKDISSALRVNPALAELNL--RSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 1038 NLSE---NGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDF 1094
+L G + +R TLQ L D L GD + G L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN--------LLGD-AGLQLLCEGLLDP- 140
Query: 1095 PAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLET 1154
+C L L C L S L + L+ P EL +S +++ +
Sbjct: 141 -----------QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRV 189
Query: 1155 LLDCLPQLP-QLSLLQLSQTGLSPKSPFLLANTLSLCPRV-KKVDLRSLHHATLHFRSNE 1212
L L P QL L+L G++ N LC V K LR L +
Sbjct: 190 LCQGLKDSPCQLEALKLESCGVTSD------NCRDLCGIVASKASLRELALGSNKLGDVG 243
Query: 1213 EEEGVCCGRFTG-----------CSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLR 1261
E +C G C ++ + LC +L + L ++ L+ N LGD G R
Sbjct: 244 MAE-LCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
Query: 1262 CLLECL--PQVPISGL---------LDLSHNSISQESALYLLETLPSCPRVREASVNLGS 1310
L E L P + L SH S +LLE S R+ +A V
Sbjct: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGV---- 358
Query: 1311 EQSFRIHFSREDQAGKTLR---LSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQ 1367
R Q G LR L++C S LA L + L EL L+ CLG
Sbjct: 359 ----RELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
Query: 1368 LAILLSLVGRPAGL 1381
+ L+ V +P L
Sbjct: 415 ILQLVESVRQPGCL 428
Score = 52.4 bits (124), Expect = 4e-06
Identities = 88/358 (24%), Positives = 132/358 (36%), Gaps = 48/358 (13%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI-ARKLDL 905
L LQ C L L + L+ P L+E+ LS N L D G +L+ E KL L
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Query: 906 SDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLM 965
LS A + + A EL +S + G + ++
Sbjct: 150 EYCSLSAASCEPLASVLRAKPDFKELTVS-----------NNDINEAGVR--------VL 190
Query: 966 LQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLA 1025
Q + P ++L CG+ + LC + L L L N LGD G +A
Sbjct: 191 CQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL--GSNKLGDVG---MA 245
Query: 1026 QLLPGL----GALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKT 1081
+L PGL L++L + E G++ L R + L L ++ GD+
Sbjct: 246 ELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE-----LGDEG 300
Query: 1082 SRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQ 1141
+R + T P C SL + C + + L LELQ
Sbjct: 301 ARLLCETLLEPG-------------CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 1142 LSCEFLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDL 1198
+S L D + L L Q L +L L+ +S S LA TL ++++DL
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Score = 45.4 bits (106), Expect = 5e-04
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 44/249 (17%)
Query: 688 IENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ +S + GD + + L T ++Q L L +T G L L P L+E
Sbjct: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
Query: 747 VSFRDNQLSDQVVLNIVE-VLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP-----TV 800
+ DN L D + + E +L RL KL L S+ ++ LA V P TV
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
Query: 801 RMLQAREADLIFLLSPPTETTAELQ-----------------------RAPDLQESDGQR 837
EA + L ++ +L+ +A + + G
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
Query: 838 K--------------GAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLE 883
K SR TL + +C + L +L+ L+E+ L+GN+L
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297
Query: 884 DEGCRLMAE 892
DEG RL+ E
Sbjct: 298 DEGARLLCE 306
Score = 45.4 bits (106), Expect = 5e-04
Identities = 58/216 (26%), Positives = 80/216 (37%), Gaps = 27/216 (12%)
Query: 688 IENLSFKSRKCGDA-FAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKE 746
+ L+ S K GD AE L RL+ L + ITA+G L + L LKE
Sbjct: 229 LRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
Query: 747 VSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAR 806
+S N+L D+ + E L L +L+ C T C + + R L
Sbjct: 289 LSLAGNELGDEGARLLCETL--LEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFL--- 343
Query: 807 EADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQ------SRSLTLRLQKCQLQVHDAE 860
ELQ + + E G R+ Q S L L C +
Sbjct: 344 ---------------LELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 861 ALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQ 896
+L A L L E+DLS N L D G + E+ Q
Sbjct: 389 SLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQ 424
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 88.2 bits (217), Expect = 7e-17
Identities = 73/240 (30%), Positives = 112/240 (46%), Gaps = 5/240 (2%)
Query: 1490 LLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALE-G 1548
L+S + L +C+ EG+ L L ++L+E+++SNN EG + + E
Sbjct: 129 LVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERN 188
Query: 1549 KWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSL 1608
+ L+LS + ALL LS ++ L L+ N DVG HL + L L
Sbjct: 189 SSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGL 248
Query: 1609 EELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELM 1668
LDLS N G L L G L K+DLS N + + L E L L R L L
Sbjct: 249 TSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLD 308
Query: 1669 LGCNALGDPTALGLAQ--ELPQHLRVLHLPFSHLGPGGALSLAQALDGSP--HLEEISLA 1724
+G N +G+ A +++ E + LRVL L + + GA+ L A+ +P +EE+ ++
Sbjct: 309 IGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDIS 368
Score = 61.6 bits (148), Expect = 7e-09
Identities = 62/238 (26%), Positives = 109/238 (45%), Gaps = 7/238 (2%)
Query: 1611 LDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLG 1670
++L+H+ +G G + +A L + K++L N I G + L E L L+E+ +
Sbjct: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
Query: 1671 CNALGDPTALGLAQELPQH---LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAEN- 1726
N LG A ++ ++ + L L + A L QAL + ++++ L+ N
Sbjct: 170 NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229
Query: 1727 --NLAGGVLRFCMELPL-LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDE 1783
++ G L + + + L +DL + A L + L + LS N G+E
Sbjct: 230 FSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNE 289
Query: 1784 AAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMA 1841
A L +VL L +D+ N I GA +++GL S++V++L+ NPI D A
Sbjct: 290 VALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGA 347
Score = 60.1 bits (144), Expect = 2e-08
Identities = 62/219 (28%), Positives = 92/219 (42%), Gaps = 6/219 (2%)
Query: 1432 EENPEAVALRLAHCDLGAHHSLLVGQLME-TCARLQQLSLSQVNLCEDDDASSLLLQSLL 1490
+EN + +++ LG + ++ E + + L LS + ED S+ LL L
Sbjct: 158 QENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKED---SAALLCQAL 214
Query: 1491 LSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKW 1550
+ ++K L+ + S G HL L L LDLS N F G AL L G
Sbjct: 215 STNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNV 274
Query: 1551 MLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
L +LDLS + L L CL L + N IG+ G +S+ L + SL
Sbjct: 275 TLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRV 334
Query: 1611 LDLSHNQIGDAGVQHLATILPGLPELR--KIDLSGNSIS 1647
L L N I G L + P+ R ++D+S +S
Sbjct: 335 LKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVS 373
Score = 54.7 bits (130), Expect = 8e-07
Identities = 66/291 (22%), Positives = 113/291 (38%), Gaps = 51/291 (17%)
Query: 1527 LDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLN 1586
++L+++ GTKA+ AL + +L+L + + L L + LQ + ++
Sbjct: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
Query: 1587 RNSIGDVGCCHLSEAL-RAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNS 1645
N +G G +S+ R ++S+ L+LS N + L L +++K+DLS N
Sbjct: 170 NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229
Query: 1646 ISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGGA 1705
S GG L + L + L L L N H R GA
Sbjct: 230 FSDVGGEHLGQMLAINVGLTSLDLSWNNF--------------HTR------------GA 263
Query: 1706 LSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFT 1765
++L L G+ L ++ L+ N N+ A L
Sbjct: 264 VALCNGLRGNVTLTKLDLSMNGFG------------------------NEVALALGEVLR 299
Query: 1766 SCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLL 1816
L + + N +G+E A+++++ L L+ + L N I GA LL
Sbjct: 300 LNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILL 350
Score = 48.9 bits (115), Expect = 5e-05
Identities = 97/397 (24%), Positives = 152/397 (38%), Gaps = 54/397 (13%)
Query: 815 SPPTETTAELQRA---PDLQESDGQRKGAQSRSLTLRLQKCQLQ-VHDAEALIALLQEGP 870
SPPT + R DL+ D ++ + L L+ C+L V I ++E
Sbjct: 51 SPPTVEKVKPARENSETDLEIEDDEKFFTTGQK-ELYLEACKLMGVVPVSYFIRNMEES- 108
Query: 871 HLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAE 930
V+L+ + L G + +A A KL+L DN + GV ++ + + L E
Sbjct: 109 ---YVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQE 165
Query: 931 LHISLQH--------------KTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSS 976
++IS H + +++ E ++ AA L +
Sbjct: 166 MNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQAL-----STNYQI 220
Query: 977 RRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQS 1036
+++ L+H + E L + L + ++G LD S N GA L L G L
Sbjct: 221 KKLDLSHNQFSDVGGEHLGQML--AINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTK 278
Query: 1037 LNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRG-DKTSRDMWATGSLPDFP 1095
L+LS NG + L L + L LDI I G K S+ + + SL
Sbjct: 279 LDLSMNGFGNEVALALGEVLRLNRCLVYLDIG--GNDIGNEGASKISKGLESNESL---- 332
Query: 1096 AAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPL--ELQLSCEFLSDQSLE 1153
R L L P+ L +K P EL +S +S+Q ++
Sbjct: 333 --------------RVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMK 378
Query: 1154 TLLDCLPQLPQLSLLQLSQTGLSPKSP-FLLANTLSL 1189
TL PQL ++ + GLSPK FLL N + L
Sbjct: 379 TLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKL 415
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 85.9 bits (211), Expect = 3e-16
Identities = 84/274 (30%), Positives = 119/274 (43%), Gaps = 30/274 (10%)
Query: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
+++A+E + + L L+ + L L L T L+ LRL N +GD L A
Sbjct: 1034 VLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAA 1093
Query: 1602 LRAATSLEELDLSHNQIGDAGVQHLATILPG---LPELRKIDLSGNSISSAGGVQLAESL 1658
L SL LDLS N +G G++ LA LPG L L ++DLS N + G LA L
Sbjct: 1094 LGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLL 1153
Query: 1659 VLCRRLEELMLGCNALG------DPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQAL 1712
C L L L G TALG A + +HL+ L L ++ L GA +LA+ L
Sbjct: 1154 HACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNAL---GAPALARTL 1210
Query: 1713 DGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
P + L +++A G + P+ R + C AL
Sbjct: 1211 QSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGC------------------ALAH 1252
Query: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKN 1806
+ LS N LGD+A +L + L L +DL N
Sbjct: 1253 LTLSANHLGDKAVRDLCRCLSLCPSLISLDLSAN 1286
Score = 55.5 bits (132), Expect = 5e-07
Identities = 81/299 (27%), Positives = 116/299 (38%), Gaps = 75/299 (25%)
Query: 1468 LSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEEL 1527
LS S +L D + LL++L L + L+ RL + + + +A L + LG L L
Sbjct: 1045 LSFSACSLALDQAQLTPLLRALKLHTA-LRELRLAGNRLGDKCVAELVAALGTMPSLALL 1103
Query: 1528 DLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLN------SSTLALLTHR-------- 1573
DLS+N EG + L L G+ L+ L+ L +N +LA L H
Sbjct: 1104 DLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHACPLLSTLR 1163
Query: 1574 -----------LSQMTCLQS----------LRLNRNSIGDVGCCHLSEALRAAT------ 1606
LS T L S L L+ N++G ++L A T
Sbjct: 1164 LQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLEL 1223
Query: 1607 -------------------------SLEELDLSHNQIGDAGVQHLATILPGLPELRKIDL 1641
+L L LS N +GD V+ L L P L +DL
Sbjct: 1224 SSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDL 1283
Query: 1642 SGN-SISSAGGVQLAESLVLCRRLEEL----MLGCNALGDPTALGLAQELPQHLRVLHL 1695
S N IS A +L +L +R + L + GC A+ P LGL ++ LR L L
Sbjct: 1284 SANPEISCASLEELLSTLQ--KRPQGLSFLGLSGC-AVQGPLGLGLWDKIAAQLRELQL 1339
Score = 49.7 bits (117), Expect = 3e-05
Identities = 66/217 (30%), Positives = 83/217 (38%), Gaps = 26/217 (11%)
Query: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMA---EAASQLHIARKL 903
LRL +L L+A L P L +DLS N L EG R +A + L +L
Sbjct: 1075 LRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEEL 1134
Query: 904 DLSDNGLSVAGVHCVLRAVSACWTLAELHIS---------LQHKTVIFMFAQEPEEQK-- 952
DLS N L + + AC L+ L + L H+T + Q+ E K
Sbjct: 1135 DLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTL 1194
Query: 953 -------GPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLG 1005
G A L SL L LSS L E L K C L
Sbjct: 1195 SLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKE---GCALA 1251
Query: 1006 HLHLDFSGNALGDEGAARLAQLLPGLGALQSLNLSEN 1042
HL L S N LGD+ L + L +L SL+LS N
Sbjct: 1252 HLTL--SANHLGDKAVRDLCRCLSLCPSLISLDLSAN 1286
Score = 48.9 bits (115), Expect = 5e-05
Identities = 91/350 (26%), Positives = 133/350 (38%), Gaps = 49/350 (14%)
Query: 687 QIENLSFKSRKCGDAFAEA----LSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCP 742
+++ L C A +A L R+L L+ L LAG+++ + ++ LV AL P
Sbjct: 1039 ELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP 1098
Query: 743 QLKEVSFRDNQLSDQVVLNIVEVLP---HLPRLRKLDLSSNSI---CVSTLLCLARVAVT 796
L + N L + + + LP L L +LDLS N + C +L L
Sbjct: 1099 SLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHACPL 1158
Query: 797 CPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQ--ESDGQRKGAQSRSLTLRLQKCQL 854
T+R LQA F LS T + Q A L+ GA + + TL+
Sbjct: 1159 LSTLR-LQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGT 1217
Query: 855 QVHDAEALIA---------------LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI 899
+H + +A L +EG L + LS N L D+ R + S
Sbjct: 1218 LLHLELSSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPS 1277
Query: 900 ARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMF-AQEPEEQKGPQERA 958
LDLS N +C +L EL +LQ + F +GP
Sbjct: 1278 LISLDLSAN------------PEISCASLEELLSTLQKRPQGLSFLGLSGCAVQGPLGLG 1325
Query: 959 AFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQL--CKALGGSCHLGH 1006
+ D + Q+ EL L SRR+ C L QL + G C L H
Sbjct: 1326 LW-DKIAAQL-RELQLCSRRL----CAEDRDALRQLQPSRPGPGECTLDH 1369
Score = 46.2 bits (108), Expect = 3e-04
Identities = 97/374 (25%), Positives = 137/374 (36%), Gaps = 79/374 (21%)
Query: 838 KGAQSRSLTLRLQKCQLQVHDAEA--LIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAAS 895
+ + + L L C L + A+ L+ L+ L E+ L+GN+L D+ + A
Sbjct: 1036 QAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALG 1095
Query: 896 QLHIARKLDLSDNGLSVAGVHCV---LRAVSACWTLAELHISLQHKTVIFMFAQEPEEQK 952
+ LDLS N L G+ + L + +L EL +S+ P
Sbjct: 1096 TMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMN-----------PLGDG 1144
Query: 953 GPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEK----HLEQLCKALGGSCHLGHLH 1008
Q A+ L + PL S +RL CG H L A + HL L
Sbjct: 1145 CGQSLASLLHAC--------PLLST-LRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLS 1195
Query: 1009 LDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDIS 1068
L + NALG AR Q LP G L L LS
Sbjct: 1196 LSY--NALGAPALARTLQSLPA-GTLLHLELSSVAAG----------------------- 1229
Query: 1069 FESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLC 1128
+GD + P F AK + C L LS L ++ LC
Sbjct: 1230 --------KGDSDLME-------PVFRYLAK-----EGCALAHLTLSANHLGDKAVRDLC 1269
Query: 1129 ATLKDCPGPLELQLSCE-FLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANT 1186
L CP + L LS +S SLE LL L + PQ LS L LS G + + P L
Sbjct: 1270 RCLSLCPSLISLDLSANPEISCASLEELLSTLQKRPQGLSFLGLS--GCAVQGPLGLGLW 1327
Query: 1187 LSLCPRVKKVDLRS 1200
+ +++++ L S
Sbjct: 1328 DKIAAQLRELQLCS 1341
Score = 43.5 bits (101), Expect = 0.002
Identities = 75/307 (24%), Positives = 116/307 (37%), Gaps = 54/307 (17%)
Query: 1222 FTGCSLS--QEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLS 1279
F+ CSL+ Q + L L L ++ L+ N LGD + L+ L +P LLDLS
Sbjct: 1047 FSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLS 1106
Query: 1280 HNSISQESALYLLETLPSCPRVR-----EASVN-----LGSEQSFRIHFSREDQAGKTLR 1329
N + E L LP ++ + S+N G + +H TLR
Sbjct: 1107 SNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHAC---PLLSTLR 1163
Query: 1330 LSECSFRP----EHVSRLATGLSKSLQLTELTLTQCCLGQKQLA-----------ILLSL 1374
L C F P H + L + + L L+L+ LG LA + L L
Sbjct: 1164 LQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLEL 1223
Query: 1375 VGRPAGLFSLRVQEP----WADRARVLSLLEVCAQASG---------------SVTEISI 1415
AG + EP A L+ L + A G S+ + +
Sbjct: 1224 SSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDL 1283
Query: 1416 SETQQQLCVQLE--FPRQEENPEAVA-LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQ 1472
S + C LE ++ P+ ++ L L+ C L +G + A+L++L L
Sbjct: 1284 SANPEISCASLEELLSTLQKRPQGLSFLGLSGC--AVQGPLGLGLWDKIAAQLRELQLCS 1341
Query: 1473 VNLCEDD 1479
LC +D
Sbjct: 1342 RRLCAED 1348
Score = 38.9 bits (89), Expect = 0.047
Identities = 89/322 (27%), Positives = 124/322 (38%), Gaps = 52/322 (16%)
Query: 1112 LCLSECPL--EPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQ 1169
L S C L + LT L LK EL+L+ L D+ + L+ L +P L+LL
Sbjct: 1045 LSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSLALLD 1104
Query: 1170 LSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQ 1229
LS L P+ LA L + L+SL L N +G CG
Sbjct: 1105 LSSNHLGPEGLRQLAMGLP-----GQATLQSLEE--LDLSMNPLGDG--CG--------- 1146
Query: 1230 EHVESLCWLLSKCKDLSQVDLSANLLGDSGL----RCLLECLPQVPISGLLDLSHNSISQ 1285
+SL LL C LS + L A G S L L LS+N++
Sbjct: 1147 ---QSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGA 1203
Query: 1286 ESALYLLETLP--SCPRVREASVNLGS------EQSFRIHFSREDQAGKTLRLSECSFRP 1337
+ L++LP + + +SV G E FR + ++E A L LS
Sbjct: 1204 PALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFR-YLAKEGCALAHLTLSANHLGD 1262
Query: 1338 EHVSRLATGLSKSLQLTELTLTQ----CCLGQKQLAILLSLVGRPAGLFSL-----RVQE 1388
+ V L LS L L L+ C ++L L +L RP GL L VQ
Sbjct: 1263 KAVRDLCRCLSLCPSLISLDLSANPEISCASLEEL--LSTLQKRPQGLSFLGLSGCAVQG 1320
Query: 1389 P-----WADRARVLSLLEVCAQ 1405
P W A L L++C++
Sbjct: 1321 PLGLGLWDKIAAQLRELQLCSR 1342
Score = 37.0 bits (84), Expect = 0.18
Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 1769 ALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGL---AQGSS 1825
AL + L+ N LGD+ AEL L M L +DL N + G LA GL A S
Sbjct: 1071 ALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQS 1130
Query: 1826 IQVIRLWNNPIPCDMAQHLKS 1846
++ + L NP+ Q L S
Sbjct: 1131 LEELDLSMNPLGDGCGQSLAS 1151
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 82.8 bits (203), Expect = 3e-15
Identities = 92/339 (27%), Positives = 140/339 (41%), Gaps = 28/339 (8%)
Query: 214 NTRVNKGP--RVTVLLGKAGMGKTTLAHRLCQKWAEGHL-NCFQALFLFEFRQLNLITRF 270
N RV GP VL G AG+GKTTLA +L WAE +L + F+ F R+L+ +
Sbjct: 197 NPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGP- 255
Query: 271 LTPSELLFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGP---------DGP 321
+ +EL+F + PE D ++ A ++L + DG DE G +
Sbjct: 256 CSFAELVFRDW--PELQDD--IPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKK 311
Query: 322 GPVLTLFSHLCNGTLLPGCRVMATSRPGKLP--ACLPAEAAMVHMLGFDGPRVEEYVNHF 379
PV L L N +LP ++ T+RP L L E + + GF Y
Sbjct: 312 KPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRH 371
Query: 380 FSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLY 439
F + A +++N L L + PA+C + C L L V T L+
Sbjct: 372 FGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLK--LQMEKGEDPVPTCLTRTGLF 429
Query: 440 MQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFC- 498
++ + + P G +L L +A +GL + + +D L G S L F
Sbjct: 430 LRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHRED----LERLGVQESDLRLFLD 485
Query: 499 --VCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKD 535
+ + Y+F HLS Q+FL AL + +D
Sbjct: 486 GDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEED 524
Score = 52.4 bits (124), Expect = 4e-06
Identities = 66/230 (28%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 1477 EDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDE 1536
+ DD L + L L+ L S +T+ A L+ L L ++LS+N+ +
Sbjct: 766 DQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLD 825
Query: 1537 EGTKALMRALEG-KWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVG- 1594
EG K L L K L+RL L + L + L L L L L +N IG+ G
Sbjct: 826 EGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGV 885
Query: 1595 ----------------------------CCHLSEALRAATSLEELDLSHNQIGDAGVQHL 1626
CC L++ L+ +SL LDL N IG G++ L
Sbjct: 886 KFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFL 945
Query: 1627 ATIL-PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALG 1675
L L LR + L G SI L +L + L L LG N LG
Sbjct: 946 CEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLG 995
Score = 48.1 bits (113), Expect = 8e-05
Identities = 51/164 (31%), Positives = 72/164 (43%), Gaps = 5/164 (3%)
Query: 1465 LQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCH-H 1523
LQ+LSL +L E A+ L ++L+ EL L + + G+ L GL +
Sbjct: 842 LQRLSLENCHLTE---ANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECK 898
Query: 1524 LEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTC-LQS 1582
L+ L L N +G L + L+ K L LDL + + L L + C L+
Sbjct: 899 LQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRC 958
Query: 1583 LRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHL 1626
L L SI C L AL SL LDL N +G +GV+ L
Sbjct: 959 LWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKML 1002
Score = 38.1 bits (87), Expect = 0.081
Identities = 56/230 (24%), Positives = 86/230 (37%), Gaps = 23/230 (10%)
Query: 1050 LGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQ-RCI 1108
LGLV C +T Q L ++ E L + + ++ G A + R +C
Sbjct: 788 LGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEG------AKLLYTTLRHPKCF 841
Query: 1109 PRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLD------CLPQL 1162
+ L L C L + L A L L L+ + + ++ L + C Q
Sbjct: 842 LQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQT 901
Query: 1163 PQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHAT--LHFRSNEEEEGVC-- 1218
L ++ G + L + LC +DL H + F + +C
Sbjct: 902 LVLWNCDITSDGCCDLTKLLQEKSSLLC-----LDLGLNHIGVKGMKFLCEALRKPLCNL 956
Query: 1219 -CGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECL 1267
C GCS+ E LC LS + L +DL N LG SG++ L E L
Sbjct: 957 RCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETL 1006
Score = 35.8 bits (81), Expect = 0.40
Identities = 68/292 (23%), Positives = 111/292 (38%), Gaps = 31/292 (10%)
Query: 1552 LKRLDLSHLLLNSSTLALLTHRLSQMTC-LQSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610
L L ++ L++S + +L +++ TC LQ + S D +L ALR ++
Sbjct: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHR-NLCLALRGHKTVTY 759
Query: 1611 LDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLG 1670
L L N D + LR + L S ++ L+ +L + + L + L
Sbjct: 760 LTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLS 819
Query: 1671 CNALGDPTALGLAQELPQ---HLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENN 1727
N L D A L L L+ L L HL LA L S L + LA+N
Sbjct: 820 DNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNP 879
Query: 1728 LAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNL-LGDEAAA 1786
+ ++F L + CK+ L+ WN + +
Sbjct: 880 IGNTGVKF-----LCEGLRYPECKLQT-------------------LVLWNCDITSDGCC 915
Query: 1787 ELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQG-SSIQVIRLWNNPIP 1837
+L ++L + L +DL N I G L E L + +++ + LW IP
Sbjct: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIP 967
Score = 32.7 bits (73), Expect = 3.4
Identities = 46/180 (25%), Positives = 71/180 (39%), Gaps = 18/180 (10%)
Query: 716 LQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPR--LR 773
L+ LGL T + + L AL + L V+ DN+L D+ + L H P+ L+
Sbjct: 785 LRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRH-PKCFLQ 843
Query: 774 KLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQES 833
+L L + + + LA V V +RE + L P T L
Sbjct: 844 RLSLENCHLTEANCKDLAAVLVV--------SRELTHLCLAKNPIGNTGVKFLCEGL--- 892
Query: 834 DGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEA 893
+ + + TL L C + L LLQE L +DL N + +G + + EA
Sbjct: 893 ----RYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEA 948
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,544,604
Number of Sequences: 37866
Number of extensions: 3400898
Number of successful extensions: 10943
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 157
Number of HSP's that attempted gapping in prelim test: 8681
Number of HSP's gapped (non-prelim): 1354
length of query: 1866
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1749
effective length of database: 13,817,196
effective search space: 24166275804
effective search space used: 24166275804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.