Guide to the Human Genome
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Search of human proteins with 116256363

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
         (567 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116256363 transmembrane protease, serine 13 [Homo sapiens]        1169   0.0  
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   278   7e-75
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   277   2e-74
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   277   2e-74
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   263   4e-70
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   261   1e-69
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          243   3e-64
gi|33695155 hepsin [Homo sapiens]                                     231   2e-60
gi|4504481 hepsin [Homo sapiens]                                      231   2e-60
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             217   2e-56
gi|223942069 enterokinase precursor [Homo sapiens]                    213   5e-55
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           211   2e-54
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          208   1e-53
gi|58218970 protease, serine, 36 [Homo sapiens]                       204   1e-52
gi|4503627 coagulation factor XI precursor [Homo sapiens]             201   2e-51
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]      200   3e-51
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         199   4e-51
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       199   6e-51
gi|21614531 testisin isoform 2 [Homo sapiens]                         197   2e-50
gi|4506153 prostasin preproprotein [Homo sapiens]                     196   4e-50
gi|5803197 testisin isoform 1 [Homo sapiens]                          196   4e-50
gi|29244926 corin [Homo sapiens]                                      196   6e-50
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           195   8e-50
gi|11415040 matriptase [Homo sapiens]                                 187   2e-47
gi|4506143 neurotrypsin precursor [Homo sapiens]                      187   2e-47
gi|4505881 plasminogen [Homo sapiens]                                 185   8e-47
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          185   8e-47
gi|68508970 tryptase beta 2 precursor [Homo sapiens]                  184   1e-46
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]            184   2e-46
gi|13994276 marapsin [Homo sapiens]                                   183   3e-46

>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score = 1169 bits (3023), Expect = 0.0
 Identities = 567/567 (100%), Positives = 567/567 (100%)

Query: 1   MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS 60
           MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS
Sbjct: 1   MERDSHGNASPARTPSAGASPAQASPAGTPPGRASPAQASPAQASPAGTPPGRASPAQAS 60

Query: 61  PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY 120
           PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY
Sbjct: 61  PAGTPPGRASPGRASPAQASPAQASPARASPALASLSRSSSGRSSSARSASVTTSPTRVY 120

Query: 121 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV 180
           LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV
Sbjct: 121 LVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLLLIALVV 180

Query: 181 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS 240
           SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS
Sbjct: 181 SLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYS 240

Query: 241 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH 300
           GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH
Sbjct: 241 GSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLH 300

Query: 301 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW 360
           RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW
Sbjct: 301 RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQW 360

Query: 361 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL 420
           VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL
Sbjct: 361 VLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRL 420

Query: 421 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC 480
           SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC
Sbjct: 421 SKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKC 480

Query: 481 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK 540
           NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK
Sbjct: 481 NDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNK 540

Query: 541 PGVYTKVTEVLPWIYSKMESEVRFRKS 567
           PGVYTKVTEVLPWIYSKMESEVRFRKS
Sbjct: 541 PGVYTKVTEVLPWIYSKMESEVRFRKS 567


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  278 bits (712), Expect = 7e-75
 Identities = 154/409 (37%), Positives = 221/409 (54%), Gaps = 21/409 (5%)

Query: 168 LIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCV 227
           +IG + L++AL + L I F      +G         C +   RCDGV DCK   DE  CV
Sbjct: 53  VIGIIALILALAIGLGIHFDC----SGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCV 108

Query: 228 RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSF- 286
           R     ++L++++ +S  W  +CS +W   Y+   C QLGF S   +  +        F 
Sbjct: 109 RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFR 166

Query: 287 -SILRYNSTIQE----SLH-----RSECPSQRYISLQCSHCG-LRAMTGRIVGGALASDS 335
              +  +  + +    +LH     R  C S   ++LQC+ CG  R  + RIVGG ++  S
Sbjct: 167 EEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLS 226

Query: 336 KWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAA 395
           +WPWQ SL F   H+CGG++I   W++TAAHC +     + + W +  G  +L   P  +
Sbjct: 227 QWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLY--LPKSWTIQVGLVSLLDNPAPS 284

Query: 396 SIAE-IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFG 454
            + E I+ +S Y  +    DIALM+L+ PLT +  I P CLP   + F   + CW +G+G
Sbjct: 285 HLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWG 344

Query: 455 KTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGP 514
            T +     SP L    V LI  K CN   VY   ++P M+CAG L GG DSCQGDSGGP
Sbjct: 345 ATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGP 404

Query: 515 LVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVR 563
           LVC++   W L G TS+G GC + NKPGVYT+VT  L WI+ +ME +++
Sbjct: 405 LVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLK 453


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  277 bits (709), Expect = 2e-74
 Identities = 162/462 (35%), Positives = 241/462 (52%), Gaps = 32/462 (6%)

Query: 115 SPTRVYLVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLL 174
           SP   Y  R     + P+  +  +S   T  T ++        T          +G  L+
Sbjct: 84  SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT----------LGTFLV 133

Query: 175 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK 233
             AL   L+  F   +  ++GI   +   +C   +  CDGV  C    DE  CVR     
Sbjct: 134 GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN 192

Query: 234 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS 293
            +L++YS     W P+C  +WN++Y    C+ +G+++   +++    D + S S ++ N+
Sbjct: 193 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT 251

Query: 294 T-----IQESLHRSE-CPSQRYISLQCSHCGLR---AMTGRIVGGALASDSKWPWQVSLH 344
           +     I + L+ S+ C S+  +SL+C  CG+    +   RIVGG  A    WPWQVSLH
Sbjct: 252 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH 311

Query: 345 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE 399
               H+CGG++I  +W++TAAHC     EK L     W  +AG      +   A   + +
Sbjct: 312 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK 367

Query: 400 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET 459
           +I + NY  +  + DIALM+L KPLT +  + P CLP  G      + CWI+G+G T E 
Sbjct: 368 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK 427

Query: 460 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ 519
             KTS  L   +V LI+ ++CN   VYD+ +TP M+CAG L+G  DSCQGDSGGPLV  +
Sbjct: 428 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK 486

Query: 520 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESE 561
           NN W+L G TSWG+GC +  +PGVY  V     WIY +M ++
Sbjct: 487 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 528


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  277 bits (709), Expect = 2e-74
 Identities = 162/462 (35%), Positives = 241/462 (52%), Gaps = 32/462 (6%)

Query: 115 SPTRVYLVRATPVGAVPIRSSPARSAPATRATRESPGTSLPKFTWREGQKQLPLIGCVLL 174
           SP   Y  R     + P+  +  +S   T  T ++        T          +G  L+
Sbjct: 47  SPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLT----------LGTFLV 96

Query: 175 LIALVVSLIILFQFWQ-GHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCVRFDWDK 233
             AL   L+  F   +  ++GI   +   +C   +  CDGV  C    DE  CVR     
Sbjct: 97  GAALAAGLLWKFMGSKCSNSGIEC-DSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN 155

Query: 234 SLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNS 293
            +L++YS     W P+C  +WN++Y    C+ +G+++   +++    D + S S ++ N+
Sbjct: 156 FILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD-SGSTSFMKLNT 214

Query: 294 T-----IQESLHRSE-CPSQRYISLQCSHCGLR---AMTGRIVGGALASDSKWPWQVSLH 344
           +     I + L+ S+ C S+  +SL+C  CG+    +   RIVGG  A    WPWQVSLH
Sbjct: 215 SAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLH 274

Query: 345 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVYAGTSNLHQLPEAAS--IAE 399
               H+CGG++I  +W++TAAHC     EK L     W  +AG      +   A   + +
Sbjct: 275 VQNVHVCGGSIITPEWIVTAAHCV----EKPLNNPWHWTAFAGILRQSFMFYGAGYQVEK 330

Query: 400 IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRET 459
           +I + NY  +  + DIALM+L KPLT +  + P CLP  G      + CWI+G+G T E 
Sbjct: 331 VISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEK 390

Query: 460 DDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ 519
             KTS  L   +V LI+ ++CN   VYD+ +TP M+CAG L+G  DSCQGDSGGPLV  +
Sbjct: 391 G-KTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSK 449

Query: 520 NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESE 561
           NN W+L G TSWG+GC +  +PGVY  V     WIY +M ++
Sbjct: 450 NNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 491


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  263 bits (671), Expect = 4e-70
 Identities = 146/410 (35%), Positives = 215/410 (52%), Gaps = 19/410 (4%)

Query: 166 LPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELG 225
           +P+I   LL +A ++ +++L +           +     P+  + CDG +DC L  DE  
Sbjct: 34  IPII-IALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQL-CDGELDCPLGEDEEH 91

Query: 226 CV-----------RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFES--AH 272
           CV           R   D+S L++   ++  W   C  N+ ++ +E  C+Q+G+ S    
Sbjct: 92  CVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTF 151

Query: 273 RTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALA 332
           R  E+      +   I   +  ++       C S   +SL C  CG    T R+VGG  A
Sbjct: 152 RAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEA 211

Query: 333 SDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLP 392
           S   WPWQVS+ +   H+CGG+++D  WVLTAAHCF   +   +  WKV AG+  L   P
Sbjct: 212 SVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCF--RKHTDVFNWKVRAGSDKLGSFP 269

Query: 393 EAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITG 452
             A    III  N    +D+ DIALM+L  PLT S  + P CLP   +  +     WI G
Sbjct: 270 SLAVAKIIIIEFNPMYPKDN-DIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIG 328

Query: 453 FGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSG 512
           +G T++   K S  L +  V +ID  +CN    Y   +T +MMCAG   GG D+CQGDSG
Sbjct: 329 WGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSG 388

Query: 513 GPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEV 562
           GPL+  Q+++W++ G+ SWG GCG  + PGVYTKV+  L WIY+  ++E+
Sbjct: 389 GPLM-YQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL 437


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  261 bits (667), Expect = 1e-69
 Identities = 145/408 (35%), Positives = 214/408 (52%), Gaps = 20/408 (4%)

Query: 166 LPLIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELG 225
           +P+I   LL +A ++ +++L +           +     P+  + CDG +DC L  DE  
Sbjct: 34  IPII-IALLSLASIIIVVVLIKVILDKYYFLCGQPLHFIPRKQL-CDGELDCPLGEDEEH 91

Query: 226 CV-----------RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRT 274
           CV           R   D+S L++   ++  W   C  N+ ++ +E  C+Q+G+    R 
Sbjct: 92  CVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYS---RA 148

Query: 275 TEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASD 334
            E+      +   I   +  ++       C S   +SL C  CG    T R+VGG  AS 
Sbjct: 149 VEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGGEEASV 208

Query: 335 SKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEA 394
             WPWQVS+ +   H+CGG+++D  WVLTAAHCF   +   +  WKV AG+  L   P  
Sbjct: 209 DSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCF--RKHTDVFNWKVRAGSDKLGSFPSL 266

Query: 395 ASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFG 454
           A    III  N    +D+ DIALM+L  PLT S  + P CLP   +  +     WI G+G
Sbjct: 267 AVAKIIIIEFNPMYPKDN-DIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWG 325

Query: 455 KTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGP 514
            T++   K S  L +  V +ID  +CN    Y   +T +MMCAG   GG D+CQGDSGGP
Sbjct: 326 FTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGP 385

Query: 515 LVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEV 562
           L+  Q+++W++ G+ SWG GCG  + PGVYTKV+  L WIY+  ++E+
Sbjct: 386 LM-YQSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWKAEL 432


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  243 bits (621), Expect = 3e-64
 Identities = 129/344 (37%), Positives = 181/344 (52%), Gaps = 9/344 (2%)

Query: 228 RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDF----A 283
           R + +  LL+       +WL +C   W+ +   + C  LG         V   D     +
Sbjct: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172

Query: 284 NSFSIL--RYNSTIQESLH-RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQ 340
             F+ L  R    ++E+   R+ C S + +SL+CS CG R +  RIVGG   +  +WPWQ
Sbjct: 173 QEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQ 232

Query: 341 VSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAG-TSNLHQLPEAASIAE 399
            S+  G  H CGG+++  +WV+TAAHC    R   L  W+V+AG  S+    P   ++ E
Sbjct: 233 ASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVE 292

Query: 400 III-NSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRE 458
            II +  Y+ +  DYD+AL+RL   L  S  +   CLP   Q F     CW++G+G T  
Sbjct: 293 RIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHP 352

Query: 459 TDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCE 518
           +   +S  L++  V L   + CN   VY   LTPRM+CAG L G  D+CQGDSGGPLVC 
Sbjct: 353 SHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCP 412

Query: 519 QNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEV 562
             + W L GV SWG GC + N PGVY KV E L WI+   +  +
Sbjct: 413 DGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSL 456


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  231 bits (588), Expect = 2e-60
 Identities = 134/372 (36%), Positives = 196/372 (52%), Gaps = 29/372 (7%)

Query: 214 VVDCKLKSDE--LGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESA 271
           +V   L+SD+  L  V+     + L ++  +   W  +CSS  N   +  +C+++GF  A
Sbjct: 39  IVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRA 98

Query: 272 HRTTEVAHRD---------FANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAM 322
              +E+  R          F      L +   + E +   +CP  R+++  C  CG R +
Sbjct: 99  LTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKL 158

Query: 323 -TGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKV 381
              RIVGG   S  +WPWQVSL +   H+CGG+L+   WVLTAAHC F  R +VL  W+V
Sbjct: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC-FPERNRVLSRWRV 217

Query: 382 YAGT---SNLHQLPEAASIAEIIINSNY------TDEEDDYDIALMRLSKPLTLSAHIHP 432
           +AG    ++ H L     +  ++ +  Y        EE+  DIAL+ LS PL L+ +I P
Sbjct: 218 FAGAVAQASPHGL--QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQP 275

Query: 433 ACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTP 492
            CLP  GQ     + C +TG+G T+    +    L+E +V +I    CN    Y + + P
Sbjct: 276 VCLPAAGQALVDGKICTVTGWGNTQYYGQQAG-VLQEARVPIISNDVCNGADFYGNQIKP 334

Query: 493 RMMCAGDLRGGRDSCQGDSGGPLVCE----QNNRWYLAGVTSWGTGCGQRNKPGVYTKVT 548
           +M CAG   GG D+CQGDSGGP VCE    +  RW L G+ SWGTGC    KPGVYTKV+
Sbjct: 335 KMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVS 394

Query: 549 EVLPWIYSKMES 560
           +   WI+  +++
Sbjct: 395 DFREWIFQAIKT 406


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  231 bits (588), Expect = 2e-60
 Identities = 134/372 (36%), Positives = 196/372 (52%), Gaps = 29/372 (7%)

Query: 214 VVDCKLKSDE--LGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESA 271
           +V   L+SD+  L  V+     + L ++  +   W  +CSS  N   +  +C+++GF  A
Sbjct: 39  IVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRA 98

Query: 272 HRTTEVAHRD---------FANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAM 322
              +E+  R          F      L +   + E +   +CP  R+++  C  CG R +
Sbjct: 99  LTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKL 158

Query: 323 -TGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKV 381
              RIVGG   S  +WPWQVSL +   H+CGG+L+   WVLTAAHC F  R +VL  W+V
Sbjct: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC-FPERNRVLSRWRV 217

Query: 382 YAGT---SNLHQLPEAASIAEIIINSNY------TDEEDDYDIALMRLSKPLTLSAHIHP 432
           +AG    ++ H L     +  ++ +  Y        EE+  DIAL+ LS PL L+ +I P
Sbjct: 218 FAGAVAQASPHGL--QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQP 275

Query: 433 ACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTP 492
            CLP  GQ     + C +TG+G T+    +    L+E +V +I    CN    Y + + P
Sbjct: 276 VCLPAAGQALVDGKICTVTGWGNTQYYGQQAG-VLQEARVPIISNDVCNGADFYGNQIKP 334

Query: 493 RMMCAGDLRGGRDSCQGDSGGPLVCE----QNNRWYLAGVTSWGTGCGQRNKPGVYTKVT 548
           +M CAG   GG D+CQGDSGGP VCE    +  RW L G+ SWGTGC    KPGVYTKV+
Sbjct: 335 KMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVS 394

Query: 549 EVLPWIYSKMES 560
           +   WI+  +++
Sbjct: 395 DFREWIFQAIKT 406


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  217 bits (553), Expect = 2e-56
 Identities = 113/253 (44%), Positives = 157/253 (62%), Gaps = 13/253 (5%)

Query: 315 SHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTT---HICGGTLIDAQWVLTAAHCFFVT 371
           S C  +  T RIVGG  +S  +WPWQVSL    T   H+CGG+LI  QWVLTAAHCF   
Sbjct: 381 SVCTTKTST-RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF--D 437

Query: 372 REKVLEGWKVYAGTSNLHQLPEA---ASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSA 428
              + + W++Y+G  NL  + +    + I EIII+ NY   E ++DIAL++L  PL  + 
Sbjct: 438 GLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTE 497

Query: 429 HIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDS 488
              P CLP  G T ++   CW+TG+G ++E  +  +  L++V + L+  ++C     Y  
Sbjct: 498 FQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQN-ILQKVNIPLVTNEECQKR--YQD 554

Query: 489 Y-LTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKV 547
           Y +T RM+CAG   GG+D+C+GDSGGPLVC+ N  W L G+TSWG GC +R +PGVYTKV
Sbjct: 555 YKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKV 614

Query: 548 TEVLPWIYSKMES 560
            E + WI  K +S
Sbjct: 615 AEYMDWILEKTQS 627


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  213 bits (541), Expect = 5e-55
 Identities = 126/370 (34%), Positives = 183/370 (49%), Gaps = 39/370 (10%)

Query: 211  CDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQ-----------WLPICSSNWNDSYS 259
            CDG + C+  SDE  CVRF         ++G+++            W   C+ NW    S
Sbjct: 662  CDGHLHCEDGSDEADCVRF---------FNGTTNNNGLVRFRIQSIWHTACAENWTTQIS 712

Query: 260  EKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESL---HRSECPSQRYISLQCSH 316
               CQ LG  S + +  +   D       ++ N+     L      +C     I LQC+H
Sbjct: 713  NDVCQLLGLGSGNSSKPIFSTDGG---PFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNH 769

Query: 317  --CGLRA----MTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFV 370
              CG +     +T +IVGG+ A +  WPW V L++G   +CG +L+ + W+++AAHC + 
Sbjct: 770  KSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVY- 828

Query: 371  TREKVLEGWKVYAGTSNLHQLPEAASIA----EIIINSNYTDEEDDYDIALMRLSKPLTL 426
             R      W    G      L    ++     EI+IN +Y     D DIA+M L   +  
Sbjct: 829  GRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNY 888

Query: 427  SAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVY 486
            + +I P CLP   Q F     C I G+G T      T+  L+E  V L+  ++C   +  
Sbjct: 889  TDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGTTANILQEADVPLLSNERCQQQMP- 946

Query: 487  DSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTK 546
            +  +T  M+CAG   GG DSCQGDSGGPL+C++NNRW+LAGVTS+G  C   N+PGVY +
Sbjct: 947  EYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYAR 1006

Query: 547  VTEVLPWIYS 556
            V+    WI S
Sbjct: 1007 VSRFTEWIQS 1016


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  211 bits (536), Expect = 2e-54
 Identities = 107/242 (44%), Positives = 149/242 (61%), Gaps = 7/242 (2%)

Query: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376
           CGL+  + RIVGGA++S+ +WPWQ SL     HICGG LI  +WV+TAAHCF        
Sbjct: 568 CGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAST 627

Query: 377 EGWKVYAGT--SNLHQLPEAA-SIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPA 433
             W V+ G    N     E +  ++ ++++  + ++  DYD+AL++L  P+  SA + P 
Sbjct: 628 VLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPV 687

Query: 434 CLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPR 493
           CLP     F     CWITG+G  RE     S  L++V V LI    C++  VY   +TPR
Sbjct: 688 CLPARSHFFEPGLHCWITGWGALRE-GGPISNALQKVDVQLIPQDLCSE--VYRYQVTPR 744

Query: 494 MMCAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLP 552
           M+CAG  +G +D+CQGDSGGPLVC+  + RW+LAG+ SWG GCG+ N  GVYT++T V+ 
Sbjct: 745 MLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVIS 804

Query: 553 WI 554
           WI
Sbjct: 805 WI 806


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  208 bits (529), Expect = 1e-53
 Identities = 127/364 (34%), Positives = 182/364 (50%), Gaps = 25/364 (6%)

Query: 204 CPKHAVRCDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWND---SYSE 260
           C   A RCDGV DC  +SDEL CV            + S  Q  P+    + D      E
Sbjct: 370 CVPQAQRCDGVNDCFDESDELFCV-----SPQPACNTSSFRQHGPLICDGFRDCENGRDE 424

Query: 261 KTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLR 320
           + C Q      +RT +       N     + N+    ++   +CP        C+     
Sbjct: 425 QNCTQ-SIPCNNRTFKC-----GNDICFRKQNAKCDGTV---DCPDGS-DEEGCTCSRSS 474

Query: 321 AMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWK 380
           +   RI+GG    +  WPWQVSLHF  +  CG ++I  +W+L+AAHCF   R      W 
Sbjct: 475 SALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWT 534

Query: 381 VYAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLS--KPLTLSAHIHPACLPMH 438
            + G          + +  I+++  Y  +  DYDIAL++LS   P TL   I P C+P  
Sbjct: 535 AHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPT 594

Query: 439 GQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAG 498
           GQ     E CW+TG+G+  E D+K S  L++ +V LID   C   +     +T RM+CAG
Sbjct: 595 GQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLC---VSTYGIITSRMLCAG 651

Query: 499 DLRGGRDSCQGDSGGPLVC--EQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYS 556
            + G RD+C+GDSGGPL C  + + +W L G+ SWG G G+ N PGVYT+V+  +PWI+ 
Sbjct: 652 IMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIHK 711

Query: 557 KMES 560
            + S
Sbjct: 712 YVPS 715


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  204 bits (520), Expect = 1e-52
 Identities = 109/252 (43%), Positives = 144/252 (57%), Gaps = 17/252 (6%)

Query: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFV--TREK 374
           CG    + RIVGG+ A    WPWQVSLH G  HICGG+LI   WVL+AAHCF    T E 
Sbjct: 38  CGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP 97

Query: 375 VLEGWKVYAGTSNLHQLPEAA---SIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIH 431
             E W V  G  +     + A   ++A I++ +NY+  E   D+AL+RL+ P +L   + 
Sbjct: 98  AAE-WSVLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVW 156

Query: 432 PACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLVYDS-- 488
           P CLP     F     CW TG+G  +E D    P+ L+EV++ L+    C    +Y    
Sbjct: 157 PVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQ--CLYSQPG 214

Query: 489 ------YLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPG 542
                  + P M+CAG   G RD+CQGDSGGPLVCE+  RW+ AG+TS+G GCG+RN+PG
Sbjct: 215 PFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPG 274

Query: 543 VYTKVTEVLPWI 554
           V+T V     WI
Sbjct: 275 VFTAVATYEAWI 286



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 55/219 (25%), Positives = 89/219 (40%), Gaps = 19/219 (8%)

Query: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376
           CGLR     +  G L     WPW   +H     +C G L+   WVL A HC        +
Sbjct: 588 CGLRLEAAPV--GVL-----WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTV 640

Query: 377 EGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEED-DYDIALMRLSKPLTLSAHIHPACL 435
              +VY G +    LP+   ++ ++I+            +AL+ LS  +  S    P CL
Sbjct: 641 PYIEVYLGRAGASSLPQGHQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICL 700

Query: 436 PMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMM 495
             H        +CW+ G+   +E  D+         V+++  + C+   +Y   L P  +
Sbjct: 701 --HPAGIPPGASCWVLGW---KEPQDRVPV---AAAVSILTQRICD--CLYQGILPPGTL 750

Query: 496 CAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGT 533
           C     G  + C+  S  PL+C+     W L G+   G+
Sbjct: 751 CVLYAEGQENRCEMTSAPPLLCQMTEGSWILVGMAVQGS 789



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/230 (24%), Positives = 93/230 (40%), Gaps = 25/230 (10%)

Query: 337 WPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTRE-----KVLEGWKVYAGTSNLHQL 391
           WPW+  +    +  C G L+   WVL  A CF          + L+ W+V      L   
Sbjct: 334 WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVL-----LPSR 388

Query: 392 PEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWIT 451
           P A  +A ++ + N    ++  D+AL++L  P+ LSA   P CLP     F     C + 
Sbjct: 389 PRAERVARLVQHEN-ASWDNASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLA 447

Query: 452 GFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLT------PRMMC-AGDLRGGR 504
            +G+        +     ++  L+    C+                P  +C A   +   
Sbjct: 448 RWGRGEPALGPGA----LLEAELLGGWWCHCLYGRQGAAVPLPGDPPHALCPAYQEKEEV 503

Query: 505 DSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554
            SC  DS   L+C++   W+LAG+  + +GC    +P  +  +    PWI
Sbjct: 504 GSCWNDSRWSLLCQEEGTWFLAGIRDFPSGC---LRPRAFFPLQTHGPWI 550


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  201 bits (510), Expect = 2e-51
 Identities = 103/244 (42%), Positives = 148/244 (60%), Gaps = 14/244 (5%)

Query: 325 RIVGGALASDSKWPWQVSLHFGTT---HICGGTLIDAQWVLTAAHCFF-VTREKVLEGWK 380
           RIVGG  +   +WPWQV+LH  +    H+CGG++I  QW+LTAAHCF+ V   K+L   +
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL---R 443

Query: 381 VYAGTSNLHQLPEAAS---IAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPM 437
           VY+G  N  ++ E  S   + EIII+  Y   E  YDIAL++L   +  +    P CLP 
Sbjct: 444 VYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPS 503

Query: 438 HGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSY-LTPRMMC 496
            G    +   CW+TG+G  R+  DK    L++ ++ L+  ++C     Y  + +T +M+C
Sbjct: 504 KGDRNVIYTDCWVTGWGY-RKLRDKIQNTLQKAKIPLVTNEECQKR--YRGHKITHKMIC 560

Query: 497 AGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYS 556
           AG   GG+D+C+GDSGGPL C+ N  W+L G+TSWG GC QR +PGVYT V E + WI  
Sbjct: 561 AGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILE 620

Query: 557 KMES 560
           K ++
Sbjct: 621 KTQA 624


>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
          Length = 321

 Score =  200 bits (508), Expect = 3e-51
 Identities = 109/253 (43%), Positives = 148/253 (58%), Gaps = 9/253 (3%)

Query: 306 SQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAA 365
           S R +   C    +    GRIVGG  A    WPWQ SL     H+CGG+L+  QWVLTAA
Sbjct: 18  SLRTLQPGCGRPQVSDAGGRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAA 77

Query: 366 HCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINSNYTDEEDDY-DIALMRLSKPL 424
           HCF  +       ++V+ G   +   P  +++ +II++S+ + +     DIAL+ LS P+
Sbjct: 78  HCFSGSLNS--SDYQVHLGELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPV 135

Query: 425 TLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCN-D 482
           TLS+ I P CLP     F     CW+TG+G TRE +    P+ LREV+V+++D + C  D
Sbjct: 136 TLSSRILPVCLPEASDDFCPGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRD 195

Query: 483 YL-VYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKP 541
           Y     S L P M+CA   RG  D+CQ DSGGPLVC+ N  W  AG+ SWG GCG+ N+P
Sbjct: 196 YPGPGGSILQPDMLCA---RGPGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRP 252

Query: 542 GVYTKVTEVLPWI 554
           GVYT+V   + WI
Sbjct: 253 GVYTRVPAYVNWI 265


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  199 bits (507), Expect = 4e-51
 Identities = 109/275 (39%), Positives = 150/275 (54%), Gaps = 13/275 (4%)

Query: 284 NSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSL 343
           +S  I + N T  +S     C ++R  +L          + RIVGG    + +WPWQ SL
Sbjct: 158 HSVKIKKINKTETDSYLNHCCGTRRSKTL--------GQSLRIVGGTEVEEGEWPWQASL 209

Query: 344 HFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIIN 403
            +  +H CG TLI+A W+++AAHCF  T  K    W    G + +        +  II++
Sbjct: 210 QWDGSHRCGATLINATWLVSAAHCF--TTYKNPARWTASFGVT-IKPSKMKRGLRRIIVH 266

Query: 404 SNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKT 463
             Y     DYDI+L  LS P+  +  +H  CLP     F   +  ++TGFG  +  D  +
Sbjct: 267 EKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKN-DGYS 325

Query: 464 SPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLV-CEQNNR 522
              LR+ QV LID   CN+   Y+  +TPRM+CAG L G  D+CQGDSGGPLV  +  + 
Sbjct: 326 QNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDI 385

Query: 523 WYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSK 557
           WYLAG+ SWG  C + NKPGVYT+VT +  WI SK
Sbjct: 386 WYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  199 bits (506), Expect = 6e-51
 Identities = 109/274 (39%), Positives = 149/274 (54%), Gaps = 13/274 (4%)

Query: 285 SFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQVSLH 344
           S  I + N T  +S     C ++R  +L          + RIVGG    + +WPWQ SL 
Sbjct: 159 SVKIKKINKTETDSYLNHCCGTRRSKTL--------GQSLRIVGGTEVEEGEWPWQASLQ 210

Query: 345 FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAASIAEIIINS 404
           +  +H CG TLI+A W+++AAHCF  T  K    W    G + +        +  II++ 
Sbjct: 211 WDGSHRCGATLINATWLVSAAHCF--TTYKNPARWTASFGVT-IKPSKMKRGLRRIIVHE 267

Query: 405 NYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTS 464
            Y     DYDI+L  LS P+  +  +H  CLP     F   +  ++TGFG  +  D  + 
Sbjct: 268 KYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKN-DGYSQ 326

Query: 465 PFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLV-CEQNNRW 523
             LR+ QV LID   CN+   Y+  +TPRM+CAG L G  D+CQGDSGGPLV  +  + W
Sbjct: 327 NHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIW 386

Query: 524 YLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSK 557
           YLAG+ SWG  C + NKPGVYT+VT +  WI SK
Sbjct: 387 YLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 420


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  197 bits (501), Expect = 2e-50
 Identities = 106/255 (41%), Positives = 142/255 (55%), Gaps = 17/255 (6%)

Query: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376
           CG R +T RIVGG  A   +WPWQ SL    +H+CG +L+  +W LTAAHCF  T     
Sbjct: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCF-ETDLSDP 91

Query: 377 EGWKVYAGTSNLHQLPEAAS---------IAEIIINSNYTDEEDDYDIALMRLSKPLTLS 427
            GW V  G   L  +P   S         ++ I ++  Y      YDIAL++LS P+T +
Sbjct: 92  SGWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSP-YDIALVKLSAPVTYT 148

Query: 428 AHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLVY 486
            HI P CL      F     CW+TG+G  +E +   SP  L+EVQV +I+   CN   + 
Sbjct: 149 KHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLK 208

Query: 487 DSY---LTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGV 543
            S+   +   M+CAG+ +GG+D+C GDSGGPL C +N  WY  GV SWG GCG+ N+PGV
Sbjct: 209 YSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPGV 268

Query: 544 YTKVTEVLPWIYSKM 558
           YT ++    WI   M
Sbjct: 269 YTNISHHFEWIQKLM 283


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  196 bits (499), Expect = 4e-50
 Identities = 103/252 (40%), Positives = 145/252 (57%), Gaps = 13/252 (5%)

Query: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376
           CG+ A   RI GG+ A   +WPWQVS+ +   H+CGG+L+  QWVL+AAHCF     K  
Sbjct: 37  CGV-APQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHK-- 93

Query: 377 EGWKVYAGTSNLHQLPEAASIA---EIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPA 433
           E ++V  G   L    E A ++   +II + +Y  E    DIAL++LS+P+T S +I P 
Sbjct: 94  EAYEVKLGAHQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPI 153

Query: 434 CLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLVYDS---- 488
           CLP    +F     C +TG+G    +    +P  L++++V LI  + CN     D+    
Sbjct: 154 CLPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEE 213

Query: 489 --YLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTK 546
             ++   M+CAG + GG+D+CQGDSGGPL C     WYL G+ SWG  CG RN+PGVYT 
Sbjct: 214 PHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTL 273

Query: 547 VTEVLPWIYSKM 558
            +    WI SK+
Sbjct: 274 ASSYASWIQSKV 285


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  196 bits (499), Expect = 4e-50
 Identities = 105/256 (41%), Positives = 142/256 (55%), Gaps = 17/256 (6%)

Query: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTRE-KV 375
           CG R +T RIVGG  A   +WPWQ SL    +H+CG +L+  +W LTAAHCF    +   
Sbjct: 33  CGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLSD 92

Query: 376 LEGWKVYAGTSNLHQLPEAAS---------IAEIIINSNYTDEEDDYDIALMRLSKPLTL 426
             GW V  G   L  +P   S         ++ I ++  Y      YDIAL++LS P+T 
Sbjct: 93  PSGWMVQFG--QLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSP-YDIALVKLSAPVTY 149

Query: 427 SAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLV 485
           + HI P CL      F     CW+TG+G  +E +   SP  L+EVQV +I+   CN   +
Sbjct: 150 TKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFL 209

Query: 486 YDSY---LTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPG 542
             S+   +   M+CAG+ +GG+D+C GDSGGPL C +N  WY  GV SWG GCG+ N+PG
Sbjct: 210 KYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRPG 269

Query: 543 VYTKVTEVLPWIYSKM 558
           VYT ++    WI   M
Sbjct: 270 VYTNISHHFEWIQKLM 285


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  196 bits (497), Expect = 6e-50
 Identities = 128/374 (34%), Positives = 188/374 (50%), Gaps = 31/374 (8%)

Query: 203  SCPKHAVRCDGVVDCKLKSDELGCVRFDWD---KSLLKIYSGSSHQWLPICSSNWNDSYS 259
            +C    + CDG  DC   SDE  CV    +    S L ++  ++     +C+  W +  S
Sbjct: 666  ACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHH--VCADGWQEILS 723

Query: 260  EKTCQQLGFESAHRTTEVAHRDFANSFSILRYN------STIQESLHRSE-CPSQRYISL 312
            +  C+Q+G      T  +  ++    +  L  N      +T+ E L   + C S+  ISL
Sbjct: 724  QLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISL 783

Query: 313  QCSH--CGLRA---MTGRIVGGALASDSKWPWQVSLHFGTT-HICGGTLIDAQWVLTAAH 366
             C+   CG R    M  RI+GG  +   +WPWQ SL    + HICG  LI  +WVLT AH
Sbjct: 784  LCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAH 843

Query: 367  CFFVTREKVLEGWKVYAGTSNLHQ---LPEAASIAEIIINSNYTDEEDDYDIALMRLSKP 423
            CF       +  WKV  G +NL       +   +  II++  Y+    DYDI+++ LS+ 
Sbjct: 844  CFEGRENAAV--WKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSED 901

Query: 424  LTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCND 482
            ++ + ++ P CLP   Q    +  C+ITG+G          PF L+E +V +I  + C  
Sbjct: 902  ISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM----GNKMPFKLQEGEVRIISLEHCQS 957

Query: 483  YLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQR-NK 540
            Y    + +T RM+CAG   G  DSC GDSGGPLVCE+   RW L G+TSWG+ C  +   
Sbjct: 958  YFDMKT-ITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLG 1016

Query: 541  PGVYTKVTEVLPWI 554
            PGVY+ V+  + WI
Sbjct: 1017 PGVYSNVSYFVEWI 1030


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  195 bits (496), Expect = 8e-50
 Identities = 100/241 (41%), Positives = 148/241 (61%), Gaps = 9/241 (3%)

Query: 325 RIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAG 384
           R+VGG  A+  + PWQVSL  G+ H CG T++  +W+L+AAHCF  T+   +E  + + G
Sbjct: 503 RVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTK---VEQVRAHLG 559

Query: 385 TSNLHQL---PEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQT 441
           T++L  L   P    +  ++++  Y     D+D+A++ L+ PL  + +I P CLP+  Q 
Sbjct: 560 TASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQK 619

Query: 442 FSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLR 501
           F +   C I+G+G T+E +      L++  V +ID K C+  ++Y+  LT RM+CAG L 
Sbjct: 620 FPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCS--VLYNFSLTDRMICAGFLE 677

Query: 502 GGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMES 560
           G  DSCQGDSGGPL CE+    +YLAG+ SWG GC Q  KPGVYT++T +  WI   M S
Sbjct: 678 GKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSS 737

Query: 561 E 561
           +
Sbjct: 738 Q 738



 Score =  187 bits (476), Expect = 2e-47
 Identities = 99/245 (40%), Positives = 141/245 (57%), Gaps = 11/245 (4%)

Query: 317 CGLRA---MTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTRE 373
           CGL+    M GRIVGG  AS  ++PWQ SL     H CG  +I+A+W+++AAHCF   ++
Sbjct: 191 CGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQD 250

Query: 374 KVLEGWKVYAGTSNLHQLPEA---ASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHI 430
                W  Y G + L     +   A + +I+ +  Y  +  D+D+A++ L+ PL    HI
Sbjct: 251 PT--KWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHI 308

Query: 431 HPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYL 490
            P CLP     F  ++ C I+G+G  +E        L++  V L+D   C    +Y   L
Sbjct: 309 QPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSL 366

Query: 491 TPRMMCAGDLRGGRDSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQRNKPGVYTKVTE 549
           T RM+CAG L G  DSCQGDSGGPLVCE+ + R++LAG+ SWG GC +  +PGVY +VT 
Sbjct: 367 TDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTR 426

Query: 550 VLPWI 554
           +  WI
Sbjct: 427 LRDWI 431



 Score =  167 bits (424), Expect = 2e-41
 Identities = 100/246 (40%), Positives = 132/246 (53%), Gaps = 9/246 (3%)

Query: 313  QCSHCGLR-AMTGRIVGGALASDSKWPWQVSLHFGTT-HICGGTLIDAQWVLTAAHCFFV 370
            Q   CGL  A   RIVGG+ A   +WPWQVSL      H CG  L+  +W+L+AAHCF V
Sbjct: 813  QLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDV 872

Query: 371  TREKVLEGWKVYAGTSNLHQLP-EAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAH 429
              +   + W  + GT  L     +   +A I  +  Y     DYD+AL+ L+ P+  S  
Sbjct: 873  YGDP--KQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRL 930

Query: 430  IHPACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSY 489
            + P CLP           C ITG+G  RE        L++  V L+  + C  +  Y   
Sbjct: 931  VRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQ-LQKAAVRLLSEQTCRRF--YPVQ 987

Query: 490  LTPRMMCAGDLRGGRDSCQGDSGGPLVC-EQNNRWYLAGVTSWGTGCGQRNKPGVYTKVT 548
            ++ RM+CAG  +GG DSC GD+GGPL C E + RW L GVTSWG GCG+ + PGVYT+V 
Sbjct: 988  ISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVA 1047

Query: 549  EVLPWI 554
             V  WI
Sbjct: 1048 AVRGWI 1053



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 2/76 (2%)

Query: 39  ASPAQASPAGTPPGRASPAQASPAGTPPGRASPGRASPAQASPAQASPARASPALASLSR 98
           + P   SP  T    A+ +  + AG     A+P R +P  AS     PA ++  L+++S 
Sbjct: 737 SQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRVTGQPANST--LSAVST 794

Query: 99  SSSGRSSSARSASVTT 114
           ++ G++    +   TT
Sbjct: 795 TARGQTPFPDAPEATT 810


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  187 bits (476), Expect = 2e-47
 Identities = 123/357 (34%), Positives = 172/357 (48%), Gaps = 28/357 (7%)

Query: 211 CDGVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSS--NWNDSYSEKTCQQLGF 268
           CD V DC   SDE GC          +  +G        C+   +  D   E +C ++  
Sbjct: 508 CDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNV 564

Query: 269 ESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAMT--GRI 326
            +  + T        N   + + N         S+   ++     C  CGLR+ T   R+
Sbjct: 565 VTCTKHTYRC----LNGLCLSKGNPECDGKEDCSDGSDEK----DCD-CGLRSFTRQARV 615

Query: 327 VGGALASDSKWPWQVSLH-FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEG---WKVY 382
           VGG  A + +WPWQVSLH  G  HICG +LI   W+++AAHC+   R         W  +
Sbjct: 616 VGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAF 675

Query: 383 AGTSNLHQLP----EAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMH 438
            G  +  Q      +   +  II +  + D   DYDIAL+ L KP   S+ + P CLP  
Sbjct: 676 LGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDA 735

Query: 439 GQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAG 498
              F   +  W+TG+G T +     +  L++ ++ +I+   C + L     +TPRMMC G
Sbjct: 736 SHVFPAGKAIWVTGWGHT-QYGGTGALILQKGEIRVINQTTCENLL--PQQITPRMMCVG 792

Query: 499 DLRGGRDSCQGDSGGPL-VCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554
            L GG DSCQGDSGGPL   E + R + AGV SWG GC QRNKPGVYT++     WI
Sbjct: 793 FLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWI 849


>gi|4506143 neurotrypsin precursor [Homo sapiens]
          Length = 875

 Score =  187 bits (476), Expect = 2e-47
 Identities = 122/363 (33%), Positives = 177/363 (48%), Gaps = 62/363 (17%)

Query: 245 QWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNST---------- 294
           QW  IC   W D  +   C+QLG++   R   +A+  F      +  ++           
Sbjct: 520 QWGTICDDGWTDKDAAVICRQLGYKGPARARTMAY--FGEGKGPIHVDNVKCTGNERSLA 577

Query: 295 --IQESLHRSECPSQRYISLQCSH-----------------CGLRAM---TGRIVGGALA 332
             I++ + R  C       + C +                 CGLR +     RI+GG  +
Sbjct: 578 DCIKQDIGRHNCRHSEDAGVICDYFGKKASGNSNKESLSSVCGLRLLHRRQKRIIGGKNS 637

Query: 333 SDSKWPWQVSLHFGTTH-----ICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYA-GTS 386
               WPWQVSL   ++H     +CG TL+ + WVLTAAHCF    ++     + YA    
Sbjct: 638 LRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCF----KRYGNSTRSYAVRVG 693

Query: 387 NLHQL-----PEAASIAEIIINSNYTDEEDDYDIALMRLSKP----LTLSAHIHPACLPM 437
           + H L      E   + +I+I+  Y  +  DYDIAL+RL  P       S+H+ PACLP+
Sbjct: 694 DYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPL 753

Query: 438 -HGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMC 496
              +       C+ITG+G T     +T   L++  + L+  + C +   Y    T RM+C
Sbjct: 754 WRERPQKTASNCYITGWGDTGRAYSRT---LQQAAIPLLPKRFCEER--YKGRFTGRMLC 808

Query: 497 AGDLRGGR--DSCQGDSGGPLVCEQ-NNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPW 553
           AG+L   +  DSCQGDSGGPL+CE+    W + GVTSWG GCG ++ PGVYTKV+  +PW
Sbjct: 809 AGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPW 868

Query: 554 IYS 556
           I S
Sbjct: 869 IKS 871



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 17/72 (23%), Positives = 28/72 (38%)

Query: 245 QWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSEC 304
           QW  +C   W+D+ +E  C+QLG     +    A+    +   +L         L   +C
Sbjct: 300 QWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQC 359

Query: 305 PSQRYISLQCSH 316
           P   +    C H
Sbjct: 360 PKSSWGEHNCGH 371



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 17/54 (31%), Positives = 31/54 (57%), Gaps = 3/54 (5%)

Query: 213 GVVDCKLKSDELGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQL 266
           G  DC+  S  L   + +++ ++ ++Y+  S  W  +CSS+W+DS +   C QL
Sbjct: 161 GYCDCRHGSVRLRGGKNEFEGTV-EVYA--SGVWGTVCSSHWDDSDASVICHQL 211


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  185 bits (470), Expect = 8e-47
 Identities = 103/239 (43%), Positives = 137/239 (57%), Gaps = 10/239 (4%)

Query: 324 GRIVGGALASDSKWPWQVSLH--FGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKV 381
           GR+VGG +A    WPWQVSL   FG  H CGGTLI  +WVLTAAHC  + +      +KV
Sbjct: 579 GRVVGGCVAHPHSWPWQVSLRTRFGM-HFCGGTLISPEWVLTAAHC--LEKSPRPSSYKV 635

Query: 382 YAGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQT 441
             G    HQ        + I  S    E    DIAL++LS P  ++  + PACLP     
Sbjct: 636 ILGA---HQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYV 692

Query: 442 FSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLR 501
            +    C+ITG+G+T+ T    +  L+E Q+ +I+ K CN Y   +  +    +CAG L 
Sbjct: 693 VADRTECFITGWGETQGTFG--AGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLA 750

Query: 502 GGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMES 560
           GG DSCQGDSGGPLVC + +++ L GVTSWG GC + NKPGVY +V+  + WI   M +
Sbjct: 751 GGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRN 809


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  185 bits (470), Expect = 8e-47
 Identities = 99/232 (42%), Positives = 131/232 (56%), Gaps = 7/232 (3%)

Query: 325 RIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAG 384
           RI+GG  A +  WPWQVSL     H CGG+LI+  W+LTAAHCF          W   +G
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNP--RDWIATSG 243

Query: 385 TSNLHQLPE-AASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFS 443
            S     P+    +  I+I++NY     + DIAL+RL   +T +  IH  CLP   Q   
Sbjct: 244 IST--TFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIP 301

Query: 444 LNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGG 503
              T ++TG+G  +E    T P LR+ QV +I    CN    Y+  +   M+CAG  +GG
Sbjct: 302 PGSTAYVTGWG-AQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGG 360

Query: 504 RDSCQGDSGGPLVCEQNNR-WYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554
            D+CQGDSGGPLV E + R W++ G+ SWG  CG  +KPGVYT+VT  L WI
Sbjct: 361 VDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWI 412


>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
          Length = 275

 Score =  184 bits (468), Expect = 1e-46
 Identities = 100/241 (41%), Positives = 137/241 (56%), Gaps = 14/241 (5%)

Query: 326 IVGGALASDSKWPWQVSLHFGTT---HICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVY 382
           IVGG  A  SKWPWQVSL        H CGG+LI  QWVLTAAHC      K L   +V 
Sbjct: 31  IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPD-VKDLAALRVQ 89

Query: 383 AGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTF 442
               +L+   +   ++ II++  +   +   DIAL+ L +P+ +S+H+H   LP   +TF
Sbjct: 90  LREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETF 149

Query: 443 SLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLVYDSY-------LTPRM 494
                CW+TG+G     +    PF L++V+V +++   C+      +Y       +   M
Sbjct: 150 PPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDM 209

Query: 495 MCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554
           +CAG+ R  RDSCQGDSGGPLVC+ N  W  AGV SWG GC Q N+PG+YT+VT  L WI
Sbjct: 210 LCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWI 267

Query: 555 Y 555
           +
Sbjct: 268 H 268


>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
          Length = 275

 Score =  184 bits (467), Expect = 2e-46
 Identities = 100/241 (41%), Positives = 137/241 (56%), Gaps = 14/241 (5%)

Query: 326 IVGGALASDSKWPWQVSLHFGTT---HICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVY 382
           IVGG  A  SKWPWQVSL        H CGG+LI  QWVLTAAHC      K L   +V 
Sbjct: 31  IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPD-VKDLAALRVQ 89

Query: 383 AGTSNLHQLPEAASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTF 442
               +L+   +   ++ II++  +   +   DIAL+ L +P+ +S+H+H   LP   +TF
Sbjct: 90  LREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETF 149

Query: 443 SLNETCWITGFGKTRETDDKTSPF-LREVQVNLIDFKKCNDYLVYDSY-------LTPRM 494
                CW+TG+G     +    PF L++V+V +++   C+      +Y       +   M
Sbjct: 150 PPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDM 209

Query: 495 MCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWI 554
           +CAG+ R  RDSCQGDSGGPLVC+ N  W  AGV SWG GC Q N+PG+YT+VT  L WI
Sbjct: 210 LCAGNTR--RDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWI 267

Query: 555 Y 555
           +
Sbjct: 268 H 268


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  183 bits (465), Expect = 3e-46
 Identities = 101/250 (40%), Positives = 135/250 (54%), Gaps = 13/250 (5%)

Query: 317 CGLRAMTGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVL 376
           CG   M  R+VGG    + +WPWQVS+    +H CGG+LI  QWVLTAAHCF  T E  L
Sbjct: 26  CGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSL 85

Query: 377 EGWKVYAGTSNLHQL-PEA--ASIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPA 433
             ++V  G   L Q  P A  A + ++  N  Y       D+AL+ L  P+  + +I P 
Sbjct: 86  --YQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPV 143

Query: 434 CLPMHGQTFSLNETCWITGFGKTRETDDKTSP-FLREVQVNLIDFKKCN-------DYLV 485
           CLP     F     CW+TG+G   E D    P  L+++ V +ID  KCN       ++  
Sbjct: 144 CLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGY 203

Query: 486 YDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYT 545
               +   M+CAG   G +D+C+GDSGGPLVC     W  AGV SWG GC ++N+PGVY 
Sbjct: 204 QPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYI 263

Query: 546 KVTEVLPWIY 555
           +VT    WI+
Sbjct: 264 RVTAHHNWIH 273


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.130    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,536,904
Number of Sequences: 37866
Number of extensions: 1494171
Number of successful extensions: 36856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 788
Number of HSP's successfully gapped in prelim test: 1680
Number of HSP's that attempted gapping in prelim test: 13895
Number of HSP's gapped (non-prelim): 13294
length of query: 567
length of database: 18,247,518
effective HSP length: 108
effective length of query: 459
effective length of database: 14,157,990
effective search space: 6498517410
effective search space used: 6498517410
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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