Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 239741341
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens]
(654 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens] 1329 0.0
gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens] 1326 0.0
gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens] 1320 0.0
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 525 e-149
gi|83281200 protogenin [Homo sapiens] 332 7e-91
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 247 3e-65
gi|157311649 neogenin homolog 1 [Homo sapiens] 187 3e-47
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 174 2e-43
gi|224994173 roundabout 1 isoform d [Homo sapiens] 141 2e-33
gi|224994171 roundabout 1 isoform c [Homo sapiens] 141 2e-33
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 141 2e-33
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 141 2e-33
gi|19743806 roundabout 1 isoform b [Homo sapiens] 139 1e-32
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 139 1e-32
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 139 1e-32
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 139 1e-32
gi|4506569 roundabout 1 isoform a [Homo sapiens] 139 1e-32
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 135 9e-32
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 135 1e-31
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 134 3e-31
gi|109150416 peroxidasin [Homo sapiens] 127 3e-29
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 126 7e-29
gi|118572606 hemicentin 1 [Homo sapiens] 122 1e-27
gi|126517478 peroxidasin homolog-like [Homo sapiens] 118 1e-26
gi|15147240 brother of CDO [Homo sapiens] 117 3e-26
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 111 2e-24
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 110 5e-24
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 107 3e-23
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 107 3e-23
gi|7657359 contactin 5 isoform long [Homo sapiens] 107 3e-23
>gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 1329 bits (3439), Expect = 0.0
Identities = 654/654 (100%), Positives = 654/654 (100%)
Query: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA
Sbjct: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
Query: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH 120
NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH
Sbjct: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH 120
Query: 121 PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM
Sbjct: 121 PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
Query: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH
Sbjct: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ
Sbjct: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
Query: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ
Sbjct: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
Query: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED
Sbjct: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
Query: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII
Sbjct: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
Query: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA
Sbjct: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
Query: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP 600
STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP
Sbjct: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP 600
Query: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS
Sbjct: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
>gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 1326 bits (3431), Expect = 0.0
Identities = 653/654 (99%), Positives = 653/654 (99%)
Query: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA
Sbjct: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
Query: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH 120
NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH
Sbjct: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH 120
Query: 121 PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
PESIEVERGGVA FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM
Sbjct: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
Query: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH
Sbjct: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ
Sbjct: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
Query: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ
Sbjct: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
Query: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED
Sbjct: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
Query: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII
Sbjct: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
Query: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA
Sbjct: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
Query: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP 600
STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP
Sbjct: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP 600
Query: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS
Sbjct: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
>gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens]
Length = 654
Score = 1320 bits (3415), Expect = 0.0
Identities = 651/654 (99%), Positives = 652/654 (99%)
Query: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA
Sbjct: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
Query: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH 120
NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSR+ARVQLASLSRFHQH
Sbjct: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH 120
Query: 121 PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
PESIEVERGGVA FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM
Sbjct: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
Query: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH
Sbjct: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ
Sbjct: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
Query: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ
Sbjct: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
Query: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED
Sbjct: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
Query: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII
Sbjct: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
Query: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA
Sbjct: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
Query: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP 600
STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSL DVP
Sbjct: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLRDVP 600
Query: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS
Sbjct: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 525 bits (1353), Expect = e-149
Identities = 313/698 (44%), Positives = 409/698 (58%), Gaps = 107/698 (15%)
Query: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
LLLL P G +ELAF E D VAV P+VL C+VEG PPV I+W+++ + L
Sbjct: 26 LLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85
Query: 63 SGVTLMPDGSL---HLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQ 119
+ TL+ +GSL H P PS +Y CVAQNR+G +VSR+AR+Q A++S FH
Sbjct: 86 THSTLLANGSLMIRHFRLEPG--GSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV 143
Query: 120 HPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTD 179
HP++ E GGVARFQC I G+P+P I+WE N ++T N R TLLP G+L IT + D
Sbjct: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAED 203
Query: 180 MGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATS 239
G + CVA N+AS R S A+LT+S +EP IL GP+NLTLTVHQTAVLEC+AT
Sbjct: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263
Query: 240 HPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTA 299
+P P+VSWSRLDGR IGVEGIQV L TGNL+ISDV+VQHSGVYVCAANRPGT VRRTA
Sbjct: 264 NPRPIVSWSRLDGRPIGVEGIQV---LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTA 320
Query: 300 QGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFV 359
QG L+VQ AP+ EFV
Sbjct: 321 QGRLVVQ--------------------------------------APA---------EFV 333
Query: 360 QWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVE 419
Q PQS+S+P G++A+FTC AQG P + WLKNG+VL PG ++RL +NNSTL ++G+ E
Sbjct: 334 QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393
Query: 420 DEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATP-PSSRD 478
DEAIYQCVAENS GS+QASARL V P P S+ V + P ++++
Sbjct: 394 DEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKE 453
Query: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
IIGYVLH+R +P E QEA+SK T +H+ S+LEP+TAY+ +++AY+ GAS S P
Sbjct: 454 IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPT 513
Query: 539 FASTMGSN----------LG-EALNL-----------------------------PVPLK 558
AST+G LG +L L P+ L
Sbjct: 514 LASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLP 573
Query: 559 ACLSQCDLAP-EPAALYDIKLQAFNGNGDGNSSARCVSLCDVPLATPDGTVSTESKTGCS 617
+S +L+ +P A+Y++KL A+N +GDGN++ R VSL + T C
Sbjct: 574 GTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSL-------RGASERTALSPPCD 626
Query: 618 CSQGES---SPLPGVVVGIHVGLAALIICLLCLFLGWR 652
C + E+ + G+V+GIH+G+ +I C+L L G R
Sbjct: 627 CRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLLFGQR 664
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 332 bits (851), Expect = 7e-91
Identities = 200/545 (36%), Positives = 285/545 (52%), Gaps = 58/545 (10%)
Query: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
LLLLL P G SEL+FV+E D + P+VL CQ GE P+ ++W ++ ++
Sbjct: 23 LLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSEN 82
Query: 63 SGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPE 122
+ ++ +GSL+++ + RR S Y C+A N+YG ++S++A + L+++S F P
Sbjct: 83 KRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPI 142
Query: 123 SIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGT 182
S EV GGVARF C I P I+WE N T L R+T LP+G+L I VSQ D G
Sbjct: 143 STEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGN 202
Query: 183 YRCVAWNVASTRHSQDAQLT-LSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHP 241
YRC+A VA R S +A LT + + P I++GPQN+T ++HQT VLEC+AT +P
Sbjct: 203 YRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP 262
Query: 242 WPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQG 301
P++SWSRLD +SI V +V L GNLMISDV +QH+GVYVC A PGT A
Sbjct: 263 KPIISWSRLDHKSIDVFNTRV---LGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMA 319
Query: 302 VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQW 361
L V P W
Sbjct: 320 TLTVLAPPSFVEW----------------------------------------------- 332
Query: 362 PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDE 421
P+SL++P +A F C A+G+P ++ WLKNG+ + +N R+ NS L++ + ED+
Sbjct: 333 PESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH--SNGRIKMYNSKLVINQIIPEDD 390
Query: 422 AIYQCVAENSTGSNQASARLVVTGGPEPPRPQGP-ACHGSLYFCHSSVLGATPP--SSRD 478
AIYQC+AENS GS + ARL V + RP P H + +L P +S
Sbjct: 391 AIYQCMAENSQGSILSRARLTVVMSED--RPSAPYNVHAETMSSSAILLAWERPLYNSDK 448
Query: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
+I Y +H + E Q I T+ ++ +LEPA+ YT ++ AY GASQ S +
Sbjct: 449 VIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508
Query: 539 FASTM 543
+T+
Sbjct: 509 TQNTL 513
Score = 32.0 bits (71), Expect = 1.8
Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 7/81 (8%)
Query: 573 LYDIKLQAFNGNGDGNSSARCVSLCDVPLAT------PDGTVSTESKTGCSCSQGESSPL 626
+Y +K+ A N G+G S V L +P T P S ++K + +
Sbjct: 890 VYIVKISASNEVGEGPFS-NSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSM 948
Query: 627 PGVVVGIHVGLAALIICLLCL 647
G+ VG+ + L ++IC+L L
Sbjct: 949 TGIAVGVGIALTCILICVLIL 969
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 247 bits (630), Expect = 3e-65
Identities = 178/528 (33%), Positives = 250/528 (47%), Gaps = 71/528 (13%)
Query: 33 EHPLVLPCQVEGE---PPVSISWQRDRLALANESGVTLMPDGSLHL----AALPSRRSLP 85
E VL C + PP ++W +D L + L+P+GSL L A S S+P
Sbjct: 50 EQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVP 109
Query: 86 SRAH----EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGV 141
Y C+A G L S+ A V+LA+L+ F HPES VE G ARF+C I+G+
Sbjct: 110 EAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGL 169
Query: 142 PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
P P I+WE + L R+ +LP+G+L I V ++D G YRCVA N A SQ+A L
Sbjct: 170 PAPIITWEKDQVTL-PEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALL 228
Query: 202 TLS-VGPLRLL--QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
+++ G L Q+ I++ P+N T+ Q+ V+EC+A++ P P VSW R DG+ I +
Sbjct: 229 SVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD 288
Query: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
I +L NL+I++ HSGVYVC AN+P T TA L RV
Sbjct: 289 VI----VLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAEL-------------RV 331
Query: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCV 378
L P+ Q P++LS+ S+A F C
Sbjct: 332 LAAPA----------------------------------ITQAPEALSRTRASTARFVCR 357
Query: 379 AQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQAS 438
A G P L WL NG L P +++ +L++ + ++D YQCVAENS G A+
Sbjct: 358 ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAA 417
Query: 439 ARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGA---TPPSSRDIIGYVLHLRPVGEPSGP 495
A L V P P + S+VL A S IIG+ LH +
Sbjct: 418 ASLAVV--VREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNV 475
Query: 496 ELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
E Q A++ T+E +LEP T Y ++ AYS GAS+ S P T+
Sbjct: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTL 523
Score = 67.0 bits (162), Expect = 5e-11
Identities = 74/323 (22%), Positives = 128/323 (39%), Gaps = 23/323 (7%)
Query: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANESGVTLMPDGSLH 74
G ++ V +T V +V+ C +P +SW R D ++ + V ++ +L
Sbjct: 241 GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD--VIVLGRTNLL 298
Query: 75 LAALPSRRSLPSRAHEYHCVAQNRYGR-LVSRQARVQLASLSRFHQHPESIEVERGGVAR 133
+A + P + Y C A R + A +++ + Q PE++ R AR
Sbjct: 299 IA-----NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353
Query: 134 FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
F C G P P++ W HNG L G L IT + D G Y+CVA N
Sbjct: 354 FVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN---- 409
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLT-VHQTAVLEC--IATSHPWPLVSWSRL 250
A + + L ++ + S P +T T + +AVL H ++ +S
Sbjct: 410 ----SAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLH 465
Query: 251 DGRSIGVEGIQVLDIL--DTGNLMISDVSVQHS-GVYVCAANRPGTHVRRTAQGVLLVQG 307
++ G++ ++ + DT L + D+ YV A ++ G T V +
Sbjct: 466 YQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDD 525
Query: 308 EPQGPNWVGRVLEHPSSLTGAWI 330
P + +PS + AW+
Sbjct: 526 VPSAAPQLSLSSPNPSDIRVAWL 548
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 187 bits (474), Expect = 3e-47
Identities = 150/568 (26%), Positives = 242/568 (42%), Gaps = 112/568 (19%)
Query: 9 PGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDR--LALANESGVT 66
PG + F+ E DT++V ++L C EP I W++D L L ++
Sbjct: 43 PGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQ 102
Query: 67 LMPDGSLHLA-ALPSRRSLPSRAHEYHCVAQ-NRYGRLVSRQARVQLASLSRFHQHPESI 124
L+PDGSL ++ + S+ + P + Y CVA G ++SR A++ +A L RF PE
Sbjct: 103 LLPDGSLFISNVVHSKHNKPDEGY-YQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161
Query: 125 EVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYR 184
V G A C + P + WE N L + RV LPSG+L I++ ++ D G YR
Sbjct: 162 SVYAGNNAILNCEVNADLVPFVRWEQNRQPL-LLDDRVIKLPSGMLVISNATEGDGGLYR 220
Query: 185 CVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSG------PQNLTLTVHQTAVLECIAT 238
CV + ++S + + L++L +PE++S P L + Q VL C+A+
Sbjct: 221 CVVESGGPPKYSDEVE-------LKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVAS 273
Query: 239 SHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRT 298
P P + W + + ++ E + L +L G+L ISDV+ +G Y C A+ +
Sbjct: 274 GLPTPTIKWMK-NEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE-- 330
Query: 299 AQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEF 358
AQ L VQ +P EF
Sbjct: 331 AQAELTVQAQP-----------------------------------------------EF 343
Query: 359 VQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSV 418
++ P ++ +F C G P + W+KNG ++ P + ++ ++ L + G+
Sbjct: 344 LKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN-LQVLGLVK 402
Query: 419 EDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRD 478
DE YQC+AEN G+ QA A+L++ PA G L P + RD
Sbjct: 403 SDEGFYQCIAENDVGNAQAGAQLIIL-------EHAPATTGPL-----------PSAPRD 444
Query: 479 IIGYVLHLR--------PVGEPSGPEL-------QEAISK---------GTSEHVFSNLE 514
++ ++ R P +P G L +E I++ G + NL
Sbjct: 445 VVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLM 504
Query: 515 PATAYTIHLRAYSAEGASQDSAPIFAST 542
PAT Y + A + G+ + SAP+ T
Sbjct: 505 PATVYIFRVMAQNKHGSGESSAPLRVET 532
Score = 102 bits (254), Expect = 1e-21
Identities = 118/518 (22%), Positives = 206/518 (39%), Gaps = 69/518 (13%)
Query: 37 VLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQ 96
+L C+V + + W+++R L + V +P G L ++ + Y CV +
Sbjct: 170 ILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVIS-----NATEGDGGLYRCVVE 224
Query: 97 NRYGRLVSRQARV------QLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEH 150
+ S + + ++ S F + P + G C+ G+P P+I W
Sbjct: 225 SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMK 284
Query: 151 NGTALNT-ANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLR 209
N AL+T ++ R+ LL G L I+ V++ D GTY C+A N T +Q A+LT+
Sbjct: 285 NEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQ-AELTVQA---- 339
Query: 210 LLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
+PE L P N+ V EC T P P V W + I + + I+
Sbjct: 340 ---QPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFK---IVKEH 393
Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
NL + + G Y C A + + AQ + +LEH + TG
Sbjct: 394 NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLI---------------ILEHAPATTGPL 438
Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ--WPQSLSKPPGSSAIFTC--VAQGVPES 385
+AP ++ F++ W S P G + ++ +G+
Sbjct: 439 P-------------SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARE 485
Query: 386 RLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTG 445
R+ PG +++T N LM A V I++ +A+N GS ++SA L V
Sbjct: 486 RVE-----NTSHPGE-MQVTIQN--LMPATVY-----IFRVMAQNKHGSGESSAPLRVET 532
Query: 446 GPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGT 505
PE P GPA + Y + + T + G + + + G + ++ + +
Sbjct: 533 QPEVQLP-GPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSS 591
Query: 506 SEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
+ + L+ T Y+ + AY+ G + + T+
Sbjct: 592 HSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629
Score = 72.0 bits (175), Expect = 2e-12
Identities = 69/325 (21%), Positives = 136/325 (41%), Gaps = 24/325 (7%)
Query: 17 SELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESG--VTLMPDGSLH 74
S+L F+++ V V +VLPC G P +I W ++ AL ES + L+ GSL
Sbjct: 247 SDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLE 306
Query: 75 LAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARF 134
++ + A Y C+A N + QA + + + F + P +I F
Sbjct: 307 ISDVTE-----DDAGTYFCIADNG-NETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 360
Query: 135 QCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTR 194
+C + G P P++ W NG + +++ ++ L + + ++D G Y+C+A N
Sbjct: 361 ECEVTGKPTPTVKWVKNGDMVIPSDY-FKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNA 419
Query: 195 HSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECI----ATSHPWPLVSWSRL 250
+ + L P P S P+++ ++ T ++ A+ +++S
Sbjct: 420 QAGAQLIILEHAPATTGPLP---SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVF 476
Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQ 310
+ G+ +V + G + ++ ++ + VY+ H + L V+ +P+
Sbjct: 477 YTKE-GIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPE 535
Query: 311 ------GPNWVGRVLEHPSSLTGAW 329
PN + P+S+T W
Sbjct: 536 VQLPGPAPN-LRAYAASPTSITVTW 559
Score = 38.1 bits (87), Expect = 0.026
Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 16/166 (9%)
Query: 317 RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQW-----PQSLSKPPGS 371
R+L PS + G RA G + + A + F + P GS
Sbjct: 9 RLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGS 68
Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLS-PGNNIRLTHNNSTLMLAGV-----SVEDEAIYQ 425
S I C A P ++ W K+G L+ ++ R + +L ++ V + DE YQ
Sbjct: 69 SVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQ 128
Query: 426 CVA--ENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVL 469
CVA E+ +A+L+V G P P+ S+Y ++++L
Sbjct: 129 CVATVESLGTIISRTAKLIVAGLPRFTSQPEPS---SVYAGNNAIL 171
Score = 29.6 bits (65), Expect = 9.2
Identities = 20/80 (25%), Positives = 41/80 (51%), Gaps = 8/80 (10%)
Query: 466 SSVLGATPPSSRDII--GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHL 523
S V+ TPP +++I+ GY + +G P ++ + + NL+P++ Y I L
Sbjct: 753 SIVVSWTPPENQNIVVRGYAIGYG-IGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITL 809
Query: 524 RAYSAEGASQDSAPIFASTM 543
+A++ G + P++ S +
Sbjct: 810 KAFNNVG---EGIPLYESAV 826
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 174 bits (441), Expect = 2e-43
Identities = 164/571 (28%), Positives = 240/571 (42%), Gaps = 110/571 (19%)
Query: 6 LLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVS-ISWQRD--RLALANE 62
L + G+ A + L F+ E D V + ++L C E + V I W++D LAL +
Sbjct: 27 LQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMD 86
Query: 63 SGVTLMPDGSLHLA-ALPSRRSLPSRAHEYHCVAQ-NRYGRLVSRQARVQLASLSRFHQH 120
+ +GSL + L SR P Y C A G ++SR A+V +A RF
Sbjct: 87 ERKQQLSNGSLLIQNILHSRHHKPDEGL-YQCEASLGDSGSIISRTAKVAVAGPLRFLSQ 145
Query: 121 PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALN--TANHRVTLLPSGILHITSVSQT 178
ES+ G +C + G P P+I W+ N L + RV +LPSG L I+ +
Sbjct: 146 TESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPG 205
Query: 179 DMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIAT 238
D+G YRC A N AS+R +A++ + P L ++ L P N+ + AVLEC +
Sbjct: 206 DIGIYRCSARNPASSRTGNEAEVRILSDP-GLHRQLYFLQRPSNVVAIEGKDAVLECCVS 264
Query: 239 SHPWPLVSWSRLDGRSIGVEGIQV----LDILDTGNLMISDVSVQHSGVYVCAANRPGTH 294
+P P +W R G E IQ+ +L NL+IS+V+ SG+Y C +
Sbjct: 265 GYPPPSFTWLR------GEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNEN 318
Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
+ +A+ +LV P W L HPS+ L A SM +
Sbjct: 319 ISASAELTVLV------PPW---FLNHPSN------------------LYAYESMDIE-- 349
Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
F C G P + W+KNG V+ P + ++ S L +
Sbjct: 350 --------------------FECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNLRIL 388
Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPP 474
GV DE YQCVAEN G+ Q SA+L+V P+P P+ SSVL P
Sbjct: 389 GVVKSDEGFYQCVAENEAGNAQTSAQLIV------PKPAIPS---------SSVL---PS 430
Query: 475 SSRDIIGYV-------LHLRPVGEPSG----------------PELQEAISKGTSEHVFS 511
+ RD++ + L RP E G G+ +
Sbjct: 431 APRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVG 490
Query: 512 NLEPATAYTIHLRAYSAEGASQDSAPIFAST 542
NL+P YT + AY+ G + S PI +T
Sbjct: 491 NLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 141 bits (356), Expect = 2e-33
Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
V+ D + P L C+ EG P +I W + + + S L+P GSL L
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL-SRFHQHPESIEVERGGVARF 134
+ R+S P Y CVA+N G VS A +++A L F Q+P + V G A
Sbjct: 92 RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C +G PEP+ISW+ +G+ L+ + R+T+ G L IT ++D G Y CV N+
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
R S+ A+LT+ L+ P + P NL +TV +A +C A P P V W + DG
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
+I D L I V+ G Y C A N G + A L VQ + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315
Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
++V GR + TG A WR SR + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
L S++ A L P Q P + + +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
+ +CVA G P ++W K+G ++S ++ N L + + D Y C+A +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
G SA + V G P +PPRP P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 106 bits (265), Expect = 6e-23
Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
R +HP + V +G A C +G P P+I W G + T +HR+ LLPSG L
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88
Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
+ S+ D G Y CVA N S +A L +++ + P ++ +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142
Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
V + AV+EC HP P +SW + DG + + ++ + G LMI+ +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199
Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
VC G N VG + LT
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218
Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
+ P FV+ P +L+ SA F C A+G P + W K +G++ IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
H TL + V+ D Y CVAEN G +ASA L V G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 92.8 bits (229), Expect = 9e-19
Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
+FV+ + + C+ G+P ++ W++D L +S + D +L +
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278
Query: 80 SRRSLPSRAHEYHCVAQNRYGRL-VSRQARVQLASLS-RFHQHPESIEVERGGVARFQCL 137
R+ Y CVA+N G+ S VQ+ S F P V G FQC
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337
Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
G P+P+I W G+ ++ R ++ +G L IT+V ++D+G Y C NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397
Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
A + ++ V R P I GP N T+ V T VL C+AT P P + W R
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454
Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
DG + + ++ L+ G L I + +G Y C A+ P +A GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 305 VQGEPQGPNWV 315
P PN +
Sbjct: 514 QPPRPTDPNLI 524
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)
Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
P V+ P L G A C A+G P + W K G+ + P ++ L + S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
L V S DE +Y CVA N G S+ AS + +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 141 bits (356), Expect = 2e-33
Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
V+ D + P L C+ EG P +I W + + + S L+P GSL L
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL-SRFHQHPESIEVERGGVARF 134
+ R+S P Y CVA+N G VS A +++A L F Q+P + V G A
Sbjct: 92 RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C +G PEP+ISW+ +G+ L+ + R+T+ G L IT ++D G Y CV N+
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
R S+ A+LT+ L+ P + P NL +TV +A +C A P P V W + DG
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
+I D L I V+ G Y C A N G + A L VQ + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315
Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
++V GR + TG A WR SR + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
L S++ A L P Q P + + +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
+ +CVA G P ++W K+G ++S ++ N L + + D Y C+A +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
G SA + V G P +PPRP P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 106 bits (265), Expect = 6e-23
Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
R +HP + V +G A C +G P P+I W G + T +HR+ LLPSG L
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88
Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
+ S+ D G Y CVA N S +A L +++ + P ++ +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142
Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
V + AV+EC HP P +SW + DG + + ++ + G LMI+ +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199
Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
VC G N VG + LT
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218
Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
+ P FV+ P +L+ SA F C A+G P + W K +G++ IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
H TL + V+ D Y CVAEN G +ASA L V G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 92.8 bits (229), Expect = 9e-19
Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
+FV+ + + C+ G+P ++ W++D L +S + D +L +
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278
Query: 80 SRRSLPSRAHEYHCVAQNRYGRL-VSRQARVQLASLS-RFHQHPESIEVERGGVARFQCL 137
R+ Y CVA+N G+ S VQ+ S F P V G FQC
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337
Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
G P+P+I W G+ ++ R ++ +G L IT+V ++D+G Y C NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397
Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
A + ++ V R P I GP N T+ V T VL C+AT P P + W R
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454
Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
DG + + ++ L+ G L I + +G Y C A+ P +A GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 305 VQGEPQGPNWV 315
P PN +
Sbjct: 514 QPPRPTDPNLI 524
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)
Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
P V+ P L G A C A+G P + W K G+ + P ++ L + S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
L V S DE +Y CVA N G S+ AS + +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 141 bits (356), Expect = 2e-33
Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
V+ D + P L C+ EG P +I W + + + S L+P GSL L
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL-SRFHQHPESIEVERGGVARF 134
+ R+S P Y CVA+N G VS A +++A L F Q+P + V G A
Sbjct: 92 RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C +G PEP+ISW+ +G+ L+ + R+T+ G L IT ++D G Y CV N+
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
R S+ A+LT+ L+ P + P NL +TV +A +C A P P V W + DG
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
+I D L I V+ G Y C A N G + A L VQ + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315
Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
++V GR + TG A WR SR + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
L S++ A L P Q P + + +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
+ +CVA G P ++W K+G ++S ++ N L + + D Y C+A +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
G SA + V G P +PPRP P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 106 bits (265), Expect = 6e-23
Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
R +HP + V +G A C +G P P+I W G + T +HR+ LLPSG L
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88
Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
+ S+ D G Y CVA N S +A L +++ + P ++ +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142
Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
V + AV+EC HP P +SW + DG + + ++ + G LMI+ +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199
Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
VC G N VG + LT
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218
Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
+ P FV+ P +L+ SA F C A+G P + W K +G++ IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
H TL + V+ D Y CVAEN G +ASA L V G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 92.8 bits (229), Expect = 9e-19
Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
+FV+ + + C+ G+P ++ W++D L +S + D +L +
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278
Query: 80 SRRSLPSRAHEYHCVAQNRYGRL-VSRQARVQLASLS-RFHQHPESIEVERGGVARFQCL 137
R+ Y CVA+N G+ S VQ+ S F P V G FQC
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337
Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
G P+P+I W G+ ++ R ++ +G L IT+V ++D+G Y C NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397
Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
A + ++ V R P I GP N T+ V T VL C+AT P P + W R
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454
Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
DG + + ++ L+ G L I + +G Y C A+ P +A GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 305 VQGEPQGPNWV 315
P PN +
Sbjct: 514 QPPRPTDPNLI 524
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)
Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
P V+ P L G A C A+G P + W K G+ + P ++ L + S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
L V S DE +Y CVA N G S+ AS + +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 141 bits (356), Expect = 2e-33
Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
V+ D + P L C+ EG P +I W + + + S L+P GSL L
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL-SRFHQHPESIEVERGGVARF 134
+ R+S P Y CVA+N G VS A +++A L F Q+P + V G A
Sbjct: 92 RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C +G PEP+ISW+ +G+ L+ + R+T+ G L IT ++D G Y CV N+
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
R S+ A+LT+ L+ P + P NL +TV +A +C A P P V W + DG
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
+I D L I V+ G Y C A N G + A L VQ + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315
Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
++V GR + TG A WR SR + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
L S++ A L P Q P + + +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
+ +CVA G P ++W K+G ++S ++ N L + + D Y C+A +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
G SA + V G P +PPRP P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521
Score = 106 bits (265), Expect = 6e-23
Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
R +HP + V +G A C +G P P+I W G + T +HR+ LLPSG L
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88
Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
+ S+ D G Y CVA N S +A L +++ + P ++ +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142
Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
V + AV+EC HP P +SW + DG + + ++ + G LMI+ +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199
Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
VC G N VG + LT
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218
Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
+ P FV+ P +L+ SA F C A+G P + W K +G++ IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
H TL + V+ D Y CVAEN G +ASA L V G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
Score = 92.8 bits (229), Expect = 9e-19
Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
+FV+ + + C+ G+P ++ W++D L +S + D +L +
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278
Query: 80 SRRSLPSRAHEYHCVAQNRYGRL-VSRQARVQLASLS-RFHQHPESIEVERGGVARFQCL 137
R+ Y CVA+N G+ S VQ+ S F P V G FQC
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337
Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
G P+P+I W G+ ++ R ++ +G L IT+V ++D+G Y C NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397
Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
A + ++ V R P I GP N T+ V T VL C+AT P P + W R
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454
Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
DG + + ++ L+ G L I + +G Y C A+ P +A GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513
Query: 305 VQGEPQGPNWV 315
P PN +
Sbjct: 514 QPPRPTDPNLI 524
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)
Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
P V+ P L G A C A+G P + W K G+ + P ++ L + S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
L V S DE +Y CVA N G S+ AS + +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 139 bits (349), Expect = 1e-32
Identities = 142/506 (28%), Positives = 207/506 (40%), Gaps = 91/506 (17%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
V+ D + P L C+ EG P +I W + + + S L+P GSL L
Sbjct: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL-SRFHQHPESIEVERGGVARF 134
+ R+S P Y CVA+N G VS A +++A L F Q+P + V G A
Sbjct: 92 RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150
Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C +G PEP+ISW+ +G+ L+ + R+T+ G L IT ++D G Y CV N+
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
R S+ A+LT+ L+ P + P NL +TV +A +C A P P V W + DG
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
+I D L I V+ G Y C A N G + A L VQ EP P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQ-EP--P 312
Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
++V GR + TG A WR SR + G
Sbjct: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
L S++ A L P Q P + + +
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
+ +CVA G P ++W K+G ++S ++ N L + + D Y C+A +
Sbjct: 433 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 492
Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
G SA + V G P +PPRP P
Sbjct: 493 GEATWSAYIEVQEFGVPVQPPRPTDP 518
Score = 100 bits (249), Expect = 4e-21
Identities = 97/347 (27%), Positives = 139/347 (40%), Gaps = 76/347 (21%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
R +HP + V +G A C +G P P+I W G + T +HR+ LLPSG L
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88
Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
+ S+ D G Y CVA N S +A L +++ + P ++ +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142
Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
V + AV+EC HP P +SW + DG + + ++ + G LMI+ +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199
Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
VC G N VG + LT
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218
Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
+ P FV+ P +L+ SA F C A+G P + W K +G++ IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
H TL + V+ D Y CVAEN G +ASA L V EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV---QEPP 312
Score = 93.2 bits (230), Expect = 7e-19
Identities = 81/309 (26%), Positives = 129/309 (41%), Gaps = 24/309 (7%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
+FV+ + + C+ G+P ++ W++D L +S + D +L +
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278
Query: 80 SRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQ 139
R+ Y CVA+N G+ A + + F P V G FQC
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 336
Query: 140 GVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAS 192
G P+P+I W G+ ++ R ++ +G L IT+V ++D+G Y C NVA
Sbjct: 337 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 396
Query: 193 TRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDG 252
+ ++ V R P I GP N T+ V T VL C+AT P P + W R DG
Sbjct: 397 SIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDG 453
Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLLVQ 306
+ + ++ L+ G L I + +G Y C A+ P +A GV +
Sbjct: 454 VLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 512
Query: 307 GEPQGPNWV 315
P PN +
Sbjct: 513 PRPTDPNLI 521
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)
Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
P V+ P L G A C A+G P + W K G+ + P ++ L + S
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
L V S DE +Y CVA N G S+ AS + +
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 139 bits (349), Expect = 1e-32
Identities = 149/545 (27%), Positives = 216/545 (39%), Gaps = 72/545 (13%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGS-LHLAALPSRRSLPSRAHEYHCV 94
LVL C VE EP I+W RD + L ++ G L L AL + S +Y C
Sbjct: 2408 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-----GDYSCT 2462
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTA 154
A+N G S RV++ ++ P ++ V A C GVP P +SW +
Sbjct: 2463 ARNAAGS-TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2521
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA-STRHSQDAQLTLSVGPLRLLQE 213
L+ + R +LP G L I V D G Y C+A N A S R +D LR+L+
Sbjct: 2522 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD---------LRVLEP 2572
Query: 214 PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ-VLDILDTGNLM 272
P I P NLTLT H A+L C A+ P PLV W + DG+ + Q +L + L+
Sbjct: 2573 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALL 2631
Query: 273 ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ---GEPQGPNWVGRVLE-----HPSS 324
++ Q S + C + R Q + V + Q V + H +
Sbjct: 2632 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691
Query: 325 L---TGAWIWRGSRAGGKRLGL-TAPSSMLLPAQL------------------------- 355
+ T +W G++ G + G +PS L Q
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2751
Query: 356 -----PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNST 410
P P + + C A G+P + W K G ++ G + ++
Sbjct: 2752 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ- 2810
Query: 411 LMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP--EPPRPQGPACHGSLYFCHSSV 468
L +A S ED Y C+A+NS GS RLVV P E P GS F
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2870
Query: 469 LGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSA 528
G+ P+ I + +PV SG E + I + + E + NLE A T A +A
Sbjct: 2871 RGSPEPN----ITWDKDGQPV---SGAEGKFTI-QPSGELLVKNLEGQDAGTYTCTAENA 2922
Query: 529 EGASQ 533
G ++
Sbjct: 2923 VGRAR 2927
Score = 139 bits (349), Expect = 1e-32
Identities = 128/461 (27%), Positives = 194/461 (42%), Gaps = 61/461 (13%)
Query: 30 AVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
AV E ++LPC+ G P +I+WQ++ L +A ++P G L +A + P A
Sbjct: 2768 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIA-----HASPEDAG 2822
Query: 90 EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWE 149
Y C+A+N G + + V + P+ + G A C +G PEP+I+W+
Sbjct: 2823 NYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPCKARGSPEPNITWD 2881
Query: 150 HNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLR 209
+G ++ A + T+ PSG L + ++ D GTY C A N A R + LT+ V P+
Sbjct: 2882 KDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRRVHLTILVLPV- 2939
Query: 210 LLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
+ P + +L + L C A P P + W+ ++ R + EG+ D
Sbjct: 2940 ------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSEQD--GGS 2989
Query: 270 NLMISDVSVQHSGVYVC-AANRPG-------THVRR------------------TAQGVL 303
L + VS + SG YVC A NR G HV+ + Q
Sbjct: 2990 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC 3049
Query: 304 LVQGEP-QGPNWV-------GRVLEHPSSLTGAWIWRGSRAGGKR--------LGLTAPS 347
+V+G+P +W+ G L H I R R R +G+
Sbjct: 3050 VVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 3109
Query: 348 SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHN 407
+L+ P F PQ ++ G C A G P + WL+ G+ L +R T
Sbjct: 3110 VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR-TLP 3168
Query: 408 NSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
+ +L L V D Y CVA N GS A A LVV G P+
Sbjct: 3169 DGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3209
Score = 108 bits (269), Expect = 2e-23
Identities = 139/603 (23%), Positives = 215/603 (35%), Gaps = 99/603 (16%)
Query: 24 ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
E G+ + +H + L C+ G P +I+W +D L + V G L R+
Sbjct: 317 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR----QLQLGRA 372
Query: 84 LPSRAHEYHCVAQNRYGRLVSRQARVQL---ASLSRFHQHPESIEVERGGVARFQCLIQG 140
S A Y C A N G + R+ + ++ P ++ G +C+ +G
Sbjct: 373 QSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431
Query: 141 VPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQ 200
P P++SW H G + +N +L + S + G Y CVA + A Q
Sbjct: 432 HPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YS 490
Query: 201 LTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
+ + V P L+ E G +T V Q L C A+ P P + W + + + G+
Sbjct: 491 VEVQVPPQLLVAE-----GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 545
Query: 261 QVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
QV T L I V + HSG++ C A N GT A+ + V GE W VL
Sbjct: 546 QVASQGTT--LHIDHVELDHSGLFACQATNEAGT---AGAEVEVSVHGE-----WAPGVL 595
Query: 320 -----------EHPSSLTGA--------------------WIWRGSRAGGKRLGLTAPSS 348
EH SS A W GS G+ G+ S
Sbjct: 596 EVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 654
Query: 349 MLLPAQL---------------------------------PEFVQWPQSLSKPPGSSAIF 375
+ P Q+ P P + + +S
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTL 714
Query: 376 TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
C+A GVP + W K + +S + ++ + L + + D Y+CVA N GS
Sbjct: 715 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774
Query: 436 QASARLVVTGGPE---PPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEP 492
+ L V P PP GP + + GA P+ + ++ PV
Sbjct: 775 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT----LMWLKDGNPVSPA 830
Query: 493 SGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTMGSNLGEALN 552
P LQ + G ++ + + A SA G + + S LGE LN
Sbjct: 831 GTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN 888
Query: 553 LPV 555
+ V
Sbjct: 889 VSV 891
Score = 102 bits (253), Expect = 1e-21
Identities = 109/416 (26%), Positives = 162/416 (38%), Gaps = 66/416 (15%)
Query: 23 QELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRR 82
+EL +V E + L CQ PP +SW +D L GV L D +L L R
Sbjct: 885 EELNVSVVANES-VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL----LQVDR 939
Query: 83 SLPSRAHEYHCVAQNRYGRLVSR-QARVQLASLSRFHQHPESIEVERGGVARFQCLIQGV 141
+ A Y C A N+ GR V +A + + ++ V G C +GV
Sbjct: 940 ADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRES-HTLTVREGHPTSLSCECRGV 998
Query: 142 PEPSISWEHNGTAL--NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
P P ISW +G L A + +L++ GTY C NV SQD
Sbjct: 999 PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG-NSSQDL 1057
Query: 200 QLTLSVGP-LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
QL + V P + +EP P +++ A LEC AT P P V+W R DG+ +G E
Sbjct: 1058 QLEVHVPPQIAGPREP-----PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAE 1111
Query: 259 -GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGR 317
G+Q+ + +L + H+G Y C A R + +LV E G
Sbjct: 1112 LGLQLQN--QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD----- 1164
Query: 318 VLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTC 377
L+ +++T A L +P ++L C
Sbjct: 1165 -LDPLTNITAA--------------LHSPLTLL--------------------------C 1183
Query: 378 VAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
A G+P + W + + +SPG + L L + +D +Y C+A N G
Sbjct: 1184 EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 1239
Score = 101 bits (252), Expect = 2e-21
Identities = 113/458 (24%), Positives = 163/458 (35%), Gaps = 64/458 (13%)
Query: 35 PLVLPCQVEGEPPVSISWQRDRLAL---ANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
P +LPC+ G P + W +D L + L+P +L L A P P + ++
Sbjct: 2589 PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTA-PG----PQDSAQF 2643
Query: 92 HCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHN 151
CV N G R +V + V C G+P P++SW
Sbjct: 2644 ECVVSNEVGE-AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2702
Query: 152 GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
G L + PSG L I G Y C A N A H + LT+ P+
Sbjct: 2703 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASPV--- 2758
Query: 212 QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
+ P + + +L C A+ P P ++W + +G ++ G+ +L G L
Sbjct: 2759 ----VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK-EGLNVAT-GVST-QVLPGGQL 2811
Query: 272 MISDVSVQHSGVYVC-AANRPGTHVRRTAQGV----LLVQGEPQGPNWVGRVLEHPSSLT 326
I+ S + +G Y+C A N G+ + +T V ++ G P G P
Sbjct: 2812 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 2871
Query: 327 GA------WIWRGSRAGGKRLGLT-APSSMLLPAQ------------------------- 354
G+ W G G T PS LL
Sbjct: 2872 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2931
Query: 355 -----LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNS 409
LP F P S G C A+G P R+ W N + ++ G + S
Sbjct: 2932 LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQDGGS 2989
Query: 410 TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
TL A VS ED Y C AEN G QA + + V P
Sbjct: 2990 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 3027
Score = 99.8 bits (247), Expect = 7e-21
Identities = 139/552 (25%), Positives = 200/552 (36%), Gaps = 95/552 (17%)
Query: 24 ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
+L A+ + LPC V P ++W +D AL+ V L+P L R+
Sbjct: 1752 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH----TLQLGRA 1807
Query: 84 LPSRAHEYHCVAQNRYGRLVSRQARVQLASL--SRFHQHP----ESIEVERGGVARFQCL 137
S + Y C A N GR Q VQL+ L F Q P +++ V G A C
Sbjct: 1808 RLSDSGMYTCEALNAAGR---DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 1864
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
+PEP+++W +G L A L L I +D G Y C NVA
Sbjct: 1865 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG----- 1919
Query: 198 DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA----VLECIATSHPWPLVSW--SRLD 251
+A T ++ +Q P P+ T TV Q A VL C + P P V+W R+
Sbjct: 1920 EAVRTFTL----TVQVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 1973
Query: 252 GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
S V G+ + G L +S + +G Y C A R+ +LV +
Sbjct: 1974 VESSAVHGV----VSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS 2029
Query: 312 PNWV-------GRVLEHPSSLTG------AWIWRGSRAG---GKRL------------GL 343
G+ + G AW+ GS G G L GL
Sbjct: 2030 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGL 2089
Query: 344 TAPS---------------------SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
A ++L+P + + +L PG C +G
Sbjct: 2090 RASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 2149
Query: 383 PESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
P + WLK+G L L + TL ++ V + D I+ CVA + G + L
Sbjct: 2150 PPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 2209
Query: 443 VTGGP--EPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPS---GP 495
V P EP Q GSL G P ++ ++ P+ S GP
Sbjct: 2210 VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP----LVSWMKDGEPLLSQSLEQGP 2265
Query: 496 ELQ-EAISKGTS 506
LQ EA+ G S
Sbjct: 2266 SLQLEAVGAGDS 2277
Score = 98.6 bits (244), Expect = 2e-20
Identities = 112/426 (26%), Positives = 167/426 (39%), Gaps = 82/426 (19%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAHEYHCV 94
L C+ +G+PP ++W +D L + G L + GSL L L + S A Y CV
Sbjct: 2046 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA-----SDAGAYTCV 2100
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPE---SIEVERGGVARFQCLIQGVPEPSISWEHN 151
A N G +R V + Q + ++ G + C ++G P +SW +
Sbjct: 2101 AHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 2159
Query: 152 GTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
G L + R L SG L I+ V D G + CVA AS D TL V +
Sbjct: 2160 GLPL-PLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGVADRNFTLQVQVPPV 2215
Query: 211 LQEPEILSGPQNLTLTVHQTAV-LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
L+ E QN + V + V L C A P PLVSW + DG + + ++
Sbjct: 2216 LEPVEF----QNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLE-----QGP 2265
Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
+L + V SG Y C A RR Q
Sbjct: 2266 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------------------------- 2296
Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
+++ P + + Q P LS PG+ C AQG P+ + W
Sbjct: 2297 -----------------LTVMEPPHIEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITW 2338
Query: 390 LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
K+G+ L+ RL +N+ + + V D +Y C+AE+ G+ + S R+ V P
Sbjct: 2339 HKDGQALT-----RLENNSRATRV--LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI 2391
Query: 450 PRPQGP 455
P+GP
Sbjct: 2392 VGPRGP 2397
Score = 98.2 bits (243), Expect = 2e-20
Identities = 120/494 (24%), Positives = 191/494 (38%), Gaps = 100/494 (20%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
+ L C G PP +SW + +++ GVT+ DG + L ++ S A Y CVA
Sbjct: 712 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVA 767
Query: 96 QN-------RYGRLVSRQARVQLASLSRFHQHPESIE--VERGGVARFQCLIQGVPEPSI 146
N RYG V+ R+ L P S+ V R C G P P++
Sbjct: 768 SNVAGSTELRYGLRVNVPPRITL---------PPSLPGPVLVNTPVRLTCNATGAPSPTL 818
Query: 147 SWEHNGTALNTANHR-VTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
W +G ++ A + + P G +L + S +D G Y CVA + +D Q +
Sbjct: 819 MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVV- 873
Query: 205 VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE-GIQVL 263
L++ P IL N+++ +++ LEC + + P P++SW + DGR + G+ +
Sbjct: 874 ---LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLEPRPGVHL- 928
Query: 264 DILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPS 323
D L + V +G Y C A N GR +H +
Sbjct: 929 -SADKALLQVDRADVWDAGHYTCEA-----------------------LNQAGRSEKHYN 964
Query: 324 SLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVP 383
W+ AP L + +L+ G +C +GVP
Sbjct: 965 --LNVWV--------------APVFPLRES---------HTLTVREGHPTSLSCECRGVP 999
Query: 384 ESRLVWLKNGKVLSPGNNIRLTHNNST---LMLAGVSVEDEAIYQCVAENSTGSNQASAR 440
++ W K+G+ L PG L H ++ L L + E Y C N G++ +
Sbjct: 1000 FPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 1058
Query: 441 LVV-----TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGP 495
L V GP P Q + + G PP+ + + +PVG G
Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT----VTWERDGQPVGAELGL 1114
Query: 496 ELQEAISKGTSEHV 509
+LQ ++G S HV
Sbjct: 1115 QLQ---NQGQSLHV 1125
Score = 97.4 bits (241), Expect = 4e-20
Identities = 131/596 (21%), Positives = 217/596 (36%), Gaps = 88/596 (14%)
Query: 31 VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
V +P L C PP ++W R+ L+ V+++ G + +P R+ A
Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRA--ENAGR 1627
Query: 91 YHCVAQNRYGRLVSRQARVQLAS---LSRFHQHPESIEVERGGVARFQCLIQGVPEPSIS 147
Y C A N G + L L + E + V QC G P P+IS
Sbjct: 1628 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1687
Query: 148 WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
W NG + + L +L +++ D +Y CVA N A S + TL V
Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG---SAEKLFTLRV-- 1742
Query: 208 LRLLQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDI 265
Q P ++G + +T ++ + L C +HP P V+W + D +++ + G +V +
Sbjct: 1743 ----QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK-DSQALSL-GEEVFLL 1796
Query: 266 LDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLV----QGEPQGPNWVGRVLEH 321
T L + + SG+Y C A ++ Q +LV + P+GP V
Sbjct: 1797 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1856
Query: 322 PSSL-----------TGAWIWRG----------SRAGGKRLGL----------------- 343
++ T W G + GG+RL +
Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 1916
Query: 344 ---TAPSSMLLPAQLPEFVQWP--QSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
A + L Q+P + P +++S+ GS + TC GVP + WLK+ +
Sbjct: 1917 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1976
Query: 399 GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPA-- 456
+ L L+ + Y CVAEN+ + + V P R G A
Sbjct: 1977 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-IRSSGVARE 2035
Query: 457 ---CHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNL 513
G G PP + ++ P+G+ GP L+ + G+
Sbjct: 2036 HHVLEGQEVRLDCEADGQPPPD----VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 2091
Query: 514 EPATAYTIHLRAYSAEGASQDSAPIF-----------ASTMGSNLGEALNLPVPLK 558
A AYT + E A + + + T+ S GE + + P++
Sbjct: 2092 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVR 2147
Score = 90.5 bits (223), Expect = 4e-18
Identities = 100/414 (24%), Positives = 162/414 (39%), Gaps = 81/414 (19%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
+ + C V G PP+ +SW +D L L L GS H + S+ L + A + CVA
Sbjct: 2140 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL--HGSGHTLRI-SKVQL-ADAGIFTCVA 2195
Query: 96 QNRYGRLVSRQ--ARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGT 153
+ G + R +VQ+ + + + V RG + C +GVP P +SW +G
Sbjct: 2196 ASPAG-VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGE 2254
Query: 154 ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA--STRHSQDAQLTLSVGPLRLL 211
L + +L L + +V D GTY CVA + A + RH Q L ++
Sbjct: 2255 PLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------LTVM 2300
Query: 212 QEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
+ P I P L+LT L C A P P ++W + DG Q L L+
Sbjct: 2301 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG--------QALTRLENN 2351
Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
+ + V+ +G+Y C A P + ++
Sbjct: 2352 SRATRVLRVRDAGLYTCLAESPAGAIEKSF------------------------------ 2381
Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
R+ + AP +++ P + P FV + PG + C + P ++ W
Sbjct: 2382 ----------RVRVQAPPNIVGP-RGPRFV-----VGLAPG-QLVLECSVEAEPAPKITW 2424
Query: 390 LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
++G VL + + L L +S D Y C A N+ GS + R+ +
Sbjct: 2425 HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2478
Score = 90.1 bits (222), Expect = 6e-18
Identities = 95/421 (22%), Positives = 156/421 (37%), Gaps = 68/421 (16%)
Query: 34 HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP----SRAH 89
HP L C+ G P ISW++D L E G H++A+ L ++
Sbjct: 987 HPTSLSCECRGVPFPKISWRKDGQPLPGEGA------GLQHVSAVGRLLYLGQAQLAQEG 1040
Query: 90 EYHCVAQNRYGRLVSRQARVQL---ASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSI 146
Y C N G S+ ++++ ++ + P + V + GVA +C G P P++
Sbjct: 1041 TYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTV 1099
Query: 147 SWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVG 206
+WE +G + LH+ G Y CVA N+A R + +L++ V
Sbjct: 1100 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELSVLVP 1158
Query: 207 PLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDIL 266
P L+ + + L+ N+T +H L C A P P + W R G G +
Sbjct: 1159 P-ELIGDLDPLT---NITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLA 1212
Query: 267 DTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
L ++ Q SG+Y C A+ RR N+ VL PS
Sbjct: 1213 GGWMLKMTQTQEQDSGLYSCLASNEAGEARR---------------NFSVEVLVPPSI-- 1255
Query: 327 GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
E + + G +A C G P+ +
Sbjct: 1256 ------------------------------ENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1285
Query: 387 LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
L W K+G+ L+ G+ ++ + L + ++ Y C+A N+ G +L V
Sbjct: 1286 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 1345
Query: 447 P 447
P
Sbjct: 1346 P 1346
Score = 89.0 bits (219), Expect = 1e-17
Identities = 111/460 (24%), Positives = 174/460 (37%), Gaps = 81/460 (17%)
Query: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHL 75
G+E + +E+ TV +P+ L C+ P +I+W +D + L+P G+ L
Sbjct: 1351 GAEDSADEEVTVTV---NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP-GTHGL 1406
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHP------ESIEVERG 129
L +++ A +Y CV N G V L S P + ++ +
Sbjct: 1407 QILNAQKE---DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463
Query: 130 GVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
+C VP P+I W +G + ++ L +L I +D G Y CVA N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523
Query: 190 VASTRHSQDAQLTLSVGPL------------RLLQEPEILSG-PQNLTLTVHQTAVLECI 236
VA QD + + V P+ L +E E G + + + A L C
Sbjct: 1524 VAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1582
Query: 237 ATSHPWPLVSWSRLD-GRSIGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTH 294
+ P P ++W R D S G E + +L G L I V +++G Y C A+
Sbjct: 1583 TNAIPPPDLTWYREDQPLSAGDE----VSVLQGGRVLQIPLVRAENAGRYSCKAS----- 1633
Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
G +W+ L L LT P ++
Sbjct: 1634 -------------NEVGEDWLHYEL---------------------LVLTPP---VILGD 1656
Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
E V + ++ S+ C A G P + WL+NG SP +++ + L ++
Sbjct: 1657 TEELV---EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 1713
Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQG 454
V D A Y CVAEN GS + +L PPR G
Sbjct: 1714 TAEVADAASYMCVAENQAGS---AEKLFTLRVQVPPRIAG 1750
Score = 85.1 bits (209), Expect = 2e-16
Identities = 98/436 (22%), Positives = 160/436 (36%), Gaps = 76/436 (17%)
Query: 25 LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
L + A PL L C+ G PP +I W R ++ L+ G + L ++
Sbjct: 1168 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM----LKMTQTQ 1223
Query: 85 PSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH--PESIEVERGGVARFQCLIQGVP 142
+ Y C+A N G R V++ E I+V G A C + G P
Sbjct: 1224 EQDSGLYSCLASNEAGE-ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP 1282
Query: 143 EPSISWEHNGTAL--NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVA--STRHSQ 197
+P ++W +G L A+H + P G+ L + + + G Y C+A N T+H Q
Sbjct: 1283 QPKLTWFKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 1339
Query: 198 DAQLTLSVGPLRLLQEPEILSGPQN-----LTLTVHQTAVLECIATSHPWPLVSWSRLDG 252
L +L P IL G ++ +T+TV+ L C A + P P ++W +
Sbjct: 1340 ----------LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389
Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQG 311
IQ+L T L I + + +G Y C N G V+ VL+
Sbjct: 1390 PFEASRNIQLLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI------- 1440
Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGS 371
P S+ L E + + S
Sbjct: 1441 ----------------------------------PPSISKDDPLGEV--GVKEVKTKVNS 1464
Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENS 431
+ C + VP + W K+G+ ++P + +++ L + V D Y CVA N
Sbjct: 1465 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1524
Query: 432 TGSNQASARLVVTGGP 447
G + +++ P
Sbjct: 1525 AGEDDQDFNVLIQVPP 1540
Score = 82.0 bits (201), Expect = 2e-15
Identities = 81/278 (29%), Positives = 116/278 (41%), Gaps = 24/278 (8%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
L L C G P I W + + GV+ GS A SR + Y C A
Sbjct: 2955 LWLRCAARGSPTPRIGWTVNDRPVTE--GVSEQDGGSTLQRAAVSRED----SGTYVCWA 3008
Query: 96 QNRYGRLVSRQARVQLASLSRFHQHPESIEVER-GGVARFQCLIQGVPEPSISWEHNGTA 154
+NR GR + V + S VE GG + C+++G P P I W +G
Sbjct: 3009 ENRVGR-TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 3067
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
L +H L +G L I + D G Y+C+A N + + V L L P
Sbjct: 3068 LR-GSHLRHQLQNGSLTIHRTERDDAGRYQCLAEN--------EMGVAKKVVILVLQSAP 3118
Query: 215 EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
PQ++T+ L C AT P P + W + G+ + + L L G+L +
Sbjct: 3119 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRAS--RRLRTLPDGSLWLE 3175
Query: 275 DVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQG 311
+V +G Y C A N G+ TA+ L+V+GEPQG
Sbjct: 3176 NVETGDAGTYDCVAHNLLGS---ATARAFLVVRGEPQG 3210
Score = 80.1 bits (196), Expect = 6e-15
Identities = 109/452 (24%), Positives = 162/452 (35%), Gaps = 99/452 (21%)
Query: 18 ELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDG-SLHLA 76
+L + LG + PL LPCQ G P +I W ++ +GV + G +LH+
Sbjct: 498 QLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHID 557
Query: 77 ALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLA------------SLSRFH---QHP 121
+ S + C A N G + A V+++ + ++H +H
Sbjct: 558 HVELDHS-----GLFACQATNEAG---TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 609
Query: 122 ESI------EVERG-GVARFQCLIQGVPEPSISW-EHNGTALNTANHRVTLLPSGILHIT 173
S V RG G L++G P W E G + +L P L I
Sbjct: 610 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIE 662
Query: 174 SVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVL 233
V D G Y C A N+A + A L++L P I GP N + + + L
Sbjct: 663 KVDLRDEGIYTCAATNLAGESKREVA--------LKVLVPPNIEPGPVNKAVLENASVTL 714
Query: 234 ECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGT 293
EC+A+ P P VSW + G + V +D L I + +G Y C A+
Sbjct: 715 ECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA- 771
Query: 294 HVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPA 353
GS L + P + LP
Sbjct: 772 ---------------------------------------GSTELRYGLRVNVPPRITLPP 792
Query: 354 QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN--NIRLTHNNSTL 411
LP P ++ P TC A G P L+WLK+G +SP +++ L
Sbjct: 793 SLP----GPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 844
Query: 412 MLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
LA D Y CVA ++ G ++ L V
Sbjct: 845 TLASARASDSGRYSCVAVSAVGEDRQDVVLQV 876
Score = 76.6 bits (187), Expect = 7e-14
Identities = 92/414 (22%), Positives = 143/414 (34%), Gaps = 68/414 (16%)
Query: 38 LPCQVEGEPPVSISWQRDRL-ALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQ 96
L C G P + W +DR L + + DG + L S Y CVA
Sbjct: 237 LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV----LRITGSHVGDEGRYQCVAF 292
Query: 97 NRYGRLV-SRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTAL 155
+ G+ Q RV + V + + C +GVP P+I+W +G L
Sbjct: 293 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 352
Query: 156 NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPE 215
T+ V L + +D G Y C A N + +L + V P
Sbjct: 353 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA-EKATRLDVYV--------PP 403
Query: 216 ILSG----PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
+ G P + + LEC+A HP P +SW +G + L+ D L
Sbjct: 404 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH-EGLPVAESNESRLE-TDGSVL 461
Query: 272 MISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIW 331
+ SG+Y C A+ P + VL E Q P P L +
Sbjct: 462 RLESPGEASSGLYSCVASSP------AGEAVLQYSVEVQVP---------PQLLVAEGLG 506
Query: 332 RGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK 391
+ + G+ P +LP C A G P + WL+
Sbjct: 507 QVTTIVGQ------------PLELP--------------------CQASGSPVPTIQWLQ 534
Query: 392 NGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTG 445
NG+ +++ +TL + V ++ ++ C A N G+ A + V G
Sbjct: 535 NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588
Score = 73.6 bits (179), Expect = 6e-13
Identities = 106/436 (24%), Positives = 156/436 (35%), Gaps = 88/436 (20%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSR 81
V+ D V V + LPC+ G P +SW +D L ++S L SL L A+ +
Sbjct: 2219 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAG 2275
Query: 82 RSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFH----QHPESIEVERGGVARFQCL 137
S Y CVA + G + QL + H P + + G C
Sbjct: 2276 DS-----GTYSCVAVSEAGEA---RRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 2327
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
QG P+P+I+W +G AL T L + + D G Y C+A + A
Sbjct: 2328 AQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKS 2380
Query: 198 DAQLTLSVGPLRLLQEPEILS--GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
+R+ P I+ GP+ + VLEC + P P ++W R DG I
Sbjct: 2381 FR--------VRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DG--I 2429
Query: 256 GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
++ + G L + +S SG Y C A R A G V
Sbjct: 2430 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA--------RNAAGSTSV--------- 2472
Query: 315 VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
RV H +P P +++ +A+
Sbjct: 2473 AFRVEIH--------------------------------TVPTIRSGPPAVNVSVNQTAL 2500
Query: 375 FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
C A GVP + W K+ L P + +L + V +D Y C+A NS GS
Sbjct: 2501 LPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 2560
Query: 435 NQASARLVVTGGPEPP 450
++ L V EPP
Sbjct: 2561 DRQGRDLRVL---EPP 2573
Score = 63.9 bits (154), Expect = 4e-10
Identities = 87/349 (24%), Positives = 132/349 (37%), Gaps = 78/349 (22%)
Query: 123 SIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHR-VTLLPSGILHITSVSQTDMG 181
++ +E GG C G P+P ++W ++ V +L G L + SVS D G
Sbjct: 16 TVGLEAGG-----CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSG 70
Query: 182 TYRCVAWN-VASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
Y C A N V ST S+ A+L + V P ++E N++ Q+ LEC A
Sbjct: 71 DYECQATNEVGST--SRRAKLVVYVPP--SIRED---GRKANVSGMAGQSLTLECDANGF 123
Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
P P + W + D + +GV +
Sbjct: 124 PVPEIVWLK-DAQLVGVP------------------------------------LGWAGY 146
Query: 301 GVLLVQGEPQGPNWV--GRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEF 358
G L G+ G + G+ L P G RG++AGG +A + A L F
Sbjct: 147 GWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGG-----SAQTKAPWXAGLAGF 201
Query: 359 VQWPQ----SLSKPP---------------GSSAIFTCVAQGVPESRLVWLKNGKVLSPG 399
Q+P S PP G+ C GVP ++ W K+ + + PG
Sbjct: 202 EQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG 261
Query: 400 N-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
++++ + L + G V DE YQCVA + G +L V P
Sbjct: 262 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPP 310
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 139 bits (349), Expect = 1e-32
Identities = 149/545 (27%), Positives = 216/545 (39%), Gaps = 72/545 (13%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGS-LHLAALPSRRSLPSRAHEYHCV 94
LVL C VE EP I+W RD + L ++ G L L AL + S +Y C
Sbjct: 3599 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-----GDYSCT 3653
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTA 154
A+N G S RV++ ++ P ++ V A C GVP P +SW +
Sbjct: 3654 ARNAAGS-TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 3712
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA-STRHSQDAQLTLSVGPLRLLQE 213
L+ + R +LP G L I V D G Y C+A N A S R +D LR+L+
Sbjct: 3713 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD---------LRVLEP 3763
Query: 214 PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ-VLDILDTGNLM 272
P I P NLTLT H A+L C A+ P PLV W + DG+ + Q +L + L+
Sbjct: 3764 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALL 3822
Query: 273 ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ---GEPQGPNWVGRVLE-----HPSS 324
++ Q S + C + R Q + V + Q V + H +
Sbjct: 3823 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882
Query: 325 L---TGAWIWRGSRAGGKRLGL-TAPSSMLLPAQL------------------------- 355
+ T +W G++ G + G +PS L Q
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 3942
Query: 356 -----PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNST 410
P P + + C A G+P + W K G ++ G + ++
Sbjct: 3943 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ- 4001
Query: 411 LMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP--EPPRPQGPACHGSLYFCHSSV 468
L +A S ED Y C+A+NS GS RLVV P E P GS F
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 4061
Query: 469 LGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSA 528
G+ P+ I + +PV SG E + I + + E + NLE A T A +A
Sbjct: 4062 RGSPEPN----ITWDKDGQPV---SGAEGKFTI-QPSGELLVKNLEGQDAGTYTCTAENA 4113
Query: 529 EGASQ 533
G ++
Sbjct: 4114 VGRAR 4118
Score = 139 bits (349), Expect = 1e-32
Identities = 128/461 (27%), Positives = 194/461 (42%), Gaps = 61/461 (13%)
Query: 30 AVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
AV E ++LPC+ G P +I+WQ++ L +A ++P G L +A + P A
Sbjct: 3959 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIA-----HASPEDAG 4013
Query: 90 EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWE 149
Y C+A+N G + + V + P+ + G A C +G PEP+I+W+
Sbjct: 4014 NYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPCKARGSPEPNITWD 4072
Query: 150 HNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLR 209
+G ++ A + T+ PSG L + ++ D GTY C A N A R + LT+ V P+
Sbjct: 4073 KDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRRVHLTILVLPV- 4130
Query: 210 LLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
+ P + +L + L C A P P + W+ ++ R + EG+ D
Sbjct: 4131 ------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSEQD--GGS 4180
Query: 270 NLMISDVSVQHSGVYVC-AANRPG-------THVRR------------------TAQGVL 303
L + VS + SG YVC A NR G HV+ + Q
Sbjct: 4181 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC 4240
Query: 304 LVQGEP-QGPNWV-------GRVLEHPSSLTGAWIWRGSRAGGKR--------LGLTAPS 347
+V+G+P +W+ G L H I R R R +G+
Sbjct: 4241 VVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 4300
Query: 348 SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHN 407
+L+ P F PQ ++ G C A G P + WL+ G+ L +R T
Sbjct: 4301 VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR-TLP 4359
Query: 408 NSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
+ +L L V D Y CVA N GS A A LVV G P+
Sbjct: 4360 DGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 4400
Score = 108 bits (271), Expect = 1e-23
Identities = 119/460 (25%), Positives = 174/460 (37%), Gaps = 81/460 (17%)
Query: 40 CQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRY 99
C G P ISW R+ AL +S + + G+L + + P A Y C A N
Sbjct: 629 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVA-----PEDAGNYSCQATNEV 683
Query: 100 GRLVSRQARVQLASLSRFHQHPESIE-------VERGGVARFQCLIQGVPEPSISWEHNG 152
G +++ ++ P S+ V G A C GVP P + W G
Sbjct: 684 G--------TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 735
Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
+ A + SG L I + + D GTY C A N A++ L+VG
Sbjct: 736 LEMILAPEGSS---SGKLRIPAAQERDAGTYTCRAVNELG---DASAEIQLAVG-----H 784
Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV-----EGIQVLDILD 267
P++ P+++T+ + ++A+L C AT P P V+W R DG+ +G+ G + D
Sbjct: 785 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ-PD 843
Query: 268 TGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG--RVLE-HPSS 324
+G L V+ + YVC A V+ A+ ++ PQ + RVLE P S
Sbjct: 844 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 903
Query: 325 L-----------TGAWIWRG-SRAGGKRLGLTAPSSMLLPAQLPE--------------- 357
L W+ G G R + A S+ L L E
Sbjct: 904 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 963
Query: 358 -------FVQWPQSLSKP-------PGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIR 403
VQ P + G A CVA GVP + W K L+
Sbjct: 964 QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 1023
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
TL++A S +D Y C A N+ G + RL V
Sbjct: 1024 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063
Score = 108 bits (269), Expect = 2e-23
Identities = 139/603 (23%), Positives = 215/603 (35%), Gaps = 99/603 (16%)
Query: 24 ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
E G+ + +H + L C+ G P +I+W +D L + V G L R+
Sbjct: 1508 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR----QLQLGRA 1563
Query: 84 LPSRAHEYHCVAQNRYGRLVSRQARVQL---ASLSRFHQHPESIEVERGGVARFQCLIQG 140
S A Y C A N G + R+ + ++ P ++ G +C+ +G
Sbjct: 1564 QSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622
Query: 141 VPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQ 200
P P++SW H G + +N +L + S + G Y CVA + A Q
Sbjct: 1623 HPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YS 1681
Query: 201 LTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
+ + V P L+ E G +T V Q L C A+ P P + W + + + G+
Sbjct: 1682 VEVQVPPQLLVAE-----GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 1736
Query: 261 QVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
QV T L I V + HSG++ C A N GT A+ + V GE W VL
Sbjct: 1737 QVASQGTT--LHIDHVELDHSGLFACQATNEAGT---AGAEVEVSVHGE-----WAPGVL 1786
Query: 320 -----------EHPSSLTGA--------------------WIWRGSRAGGKRLGLTAPSS 348
EH SS A W GS G+ G+ S
Sbjct: 1787 EVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 1845
Query: 349 MLLPAQL---------------------------------PEFVQWPQSLSKPPGSSAIF 375
+ P Q+ P P + + +S
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTL 1905
Query: 376 TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
C+A GVP + W K + +S + ++ + L + + D Y+CVA N GS
Sbjct: 1906 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965
Query: 436 QASARLVVTGGPE---PPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEP 492
+ L V P PP GP + + GA P+ + ++ PV
Sbjct: 1966 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT----LMWLKDGNPVSPA 2021
Query: 493 SGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTMGSNLGEALN 552
P LQ + G ++ + + A SA G + + S LGE LN
Sbjct: 2022 GTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN 2079
Query: 553 LPV 555
+ V
Sbjct: 2080 VSV 2082
Score = 101 bits (252), Expect = 2e-21
Identities = 113/458 (24%), Positives = 163/458 (35%), Gaps = 64/458 (13%)
Query: 35 PLVLPCQVEGEPPVSISWQRDRLAL---ANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
P +LPC+ G P + W +D L + L+P +L L A P P + ++
Sbjct: 3780 PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTA-PG----PQDSAQF 3834
Query: 92 HCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHN 151
CV N G R +V + V C G+P P++SW
Sbjct: 3835 ECVVSNEVGE-AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 3893
Query: 152 GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
G L + PSG L I G Y C A N A H + LT+ P+
Sbjct: 3894 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASPV--- 3949
Query: 212 QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
+ P + + +L C A+ P P ++W + +G ++ G+ +L G L
Sbjct: 3950 ----VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK-EGLNVAT-GVST-QVLPGGQL 4002
Query: 272 MISDVSVQHSGVYVC-AANRPGTHVRRTAQGV----LLVQGEPQGPNWVGRVLEHPSSLT 326
I+ S + +G Y+C A N G+ + +T V ++ G P G P
Sbjct: 4003 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 4062
Query: 327 GA------WIWRGSRAGGKRLGLT-APSSMLLPAQ------------------------- 354
G+ W G G T PS LL
Sbjct: 4063 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 4122
Query: 355 -----LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNS 409
LP F P S G C A+G P R+ W N + ++ G + S
Sbjct: 4123 LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQDGGS 4180
Query: 410 TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
TL A VS ED Y C AEN G QA + + V P
Sbjct: 4181 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 4218
Score = 101 bits (251), Expect = 2e-21
Identities = 124/468 (26%), Positives = 170/468 (36%), Gaps = 117/468 (25%)
Query: 28 TVAVWE-HPLVLPCQV-EGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP 85
TV V E P+ LPC V G P W +D L S ++ DGSLHL R+L
Sbjct: 893 TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-----RALQ 947
Query: 86 SRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIE--VERGGVARFQCLIQGVPE 143
A Y CVA N G S+ V+L HP + G A C+ GVP
Sbjct: 948 EHAGRYSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 1004
Query: 144 PSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLT- 202
P+I+W AL + + G L I S D G Y C A N SQ+ +L+
Sbjct: 1005 PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF-SSQEMRLSV 1063
Query: 203 ---------------LSVGPLRLLQ------------------------------EPEIL 217
L G LRL Q P++
Sbjct: 1064 NRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQ 1123
Query: 218 SGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVS 277
GP+ L + V + L C+A +P P +SWS+ DG + G Q G++ + +
Sbjct: 1124 PGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK-DGVVLQGRGPQ-------GSVHFAAIR 1175
Query: 278 VQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAG 337
+G Y C A+ + GV + E RVLE P W
Sbjct: 1176 TSDAGRYRCEAS--------NSAGVDAWEVEL-------RVLEPPH-------WGADETS 1213
Query: 338 GKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK--NGKV 395
G L + G +A C A+G P+ ++ W K + +
Sbjct: 1214 G-------------------------LLERVAGENASLPCPARGTPKPQVTWRKGPSSEP 1248
Query: 396 LSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
L + + S L LA VS D Y+C A N GS A+LVV
Sbjct: 1249 LHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 100 bits (248), Expect = 6e-21
Identities = 117/443 (26%), Positives = 180/443 (40%), Gaps = 70/443 (15%)
Query: 37 VLPCQVEGEPPVSISWQRD-------RLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
+L C+ G PP +++W+R RL S G L ++ P
Sbjct: 804 LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP---- 859
Query: 90 EYHCVAQNRYGR-------LVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLI-QGV 141
Y C A+N +G+ +V+ A Q+AS + ++ V G C++ G
Sbjct: 860 -YVCEARNVFGKVQAEARLIVTGHAPPQIASSA------PTVRVLEGQPVSLPCIVLAGR 912
Query: 142 PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
P P W +G L + R ++ G LH+ Q G Y CVA N A ++H +D +L
Sbjct: 913 PLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH-RDVEL 970
Query: 202 TLSVGPLRLLQEPEILSGPQNLTLTVHQT-----AVLECIATSHPWPLVSWSRLDGRSIG 256
+ V P R+ + T T H T A L C+A+ P P ++W++ + ++
Sbjct: 971 VVQVPP-RI-----------HPTATHHITNEGVPASLPCVASGVPAPTITWTK-ETNALT 1017
Query: 257 VEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPG-------THVRRTAQGVLLVQGE 308
G ++ G L+I+ S Q +G YVC A N G V R A + +
Sbjct: 1018 SRGPH-YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEY 1076
Query: 309 PQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ-WPQSLSK 367
P+ R+ + +G + S G +A +L Q+P VQ P+ L
Sbjct: 1077 GLLPSGSLRLAQVQVGDSGHYECTASNPAG-----SASHRYVLGVQVPPQVQPGPRVLKV 1131
Query: 368 PPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCV 427
G + CVA+G PE +L W K+G VL H A + D Y+C
Sbjct: 1132 LVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVH------FAAIRTSDAGRYRCE 1185
Query: 428 AENSTGSNQASARLVVTGGPEPP 450
A NS G + L V EPP
Sbjct: 1186 ASNSAGVDAWEVELRVL---EPP 1205
Score = 100 bits (248), Expect = 6e-21
Identities = 108/416 (25%), Positives = 161/416 (38%), Gaps = 66/416 (15%)
Query: 23 QELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRR 82
+EL +V E + L CQ PP +SW +D L GV L D +L L R
Sbjct: 2076 EELNVSVVANES-VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL----LQVDR 2130
Query: 83 SLPSRAHEYHCVAQNRYGRLVSR-QARVQLASLSRFHQHPESIEVERGGVARFQCLIQGV 141
+ A Y C A N+ G V +A + + ++ V G C +GV
Sbjct: 2131 ADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRES-HTLTVREGHPTSLSCECRGV 2189
Query: 142 PEPSISWEHNGTAL--NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
P P ISW +G L A + +L++ GTY C NV SQD
Sbjct: 2190 PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG-NSSQDL 2248
Query: 200 QLTLSVGP-LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
QL + V P + +EP P +++ A LEC AT P P V+W R DG+ +G E
Sbjct: 2249 QLEVHVPPQIAGPREP-----PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAE 2302
Query: 259 -GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGR 317
G+Q+ + +L + H+G Y C A R + +LV E G
Sbjct: 2303 LGLQLQN--QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD----- 2355
Query: 318 VLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTC 377
L+ +++T A L +P ++L C
Sbjct: 2356 -LDPLTNITAA--------------LHSPLTLL--------------------------C 2374
Query: 378 VAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
A G+P + W + + +SPG + L L + +D +Y C+A N G
Sbjct: 2375 EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 2430
Score = 99.8 bits (247), Expect = 7e-21
Identities = 139/552 (25%), Positives = 200/552 (36%), Gaps = 95/552 (17%)
Query: 24 ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
+L A+ + LPC V P ++W +D AL+ V L+P L R+
Sbjct: 2943 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH----TLQLGRA 2998
Query: 84 LPSRAHEYHCVAQNRYGRLVSRQARVQLASL--SRFHQHP----ESIEVERGGVARFQCL 137
S + Y C A N GR Q VQL+ L F Q P +++ V G A C
Sbjct: 2999 RLSDSGMYTCEALNAAGR---DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 3055
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
+PEP+++W +G L A L L I +D G Y C NVA
Sbjct: 3056 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG----- 3110
Query: 198 DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA----VLECIATSHPWPLVSW--SRLD 251
+A T ++ +Q P P+ T TV Q A VL C + P P V+W R+
Sbjct: 3111 EAVRTFTL----TVQVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 3164
Query: 252 GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
S V G+ + G L +S + +G Y C A R+ +LV +
Sbjct: 3165 VESSAVHGV----VSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS 3220
Query: 312 PNWV-------GRVLEHPSSLTG------AWIWRGSRAG---GKRL------------GL 343
G+ + G AW+ GS G G L GL
Sbjct: 3221 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGL 3280
Query: 344 TAPS---------------------SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
A ++L+P + + +L PG C +G
Sbjct: 3281 RASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 3340
Query: 383 PESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
P + WLK+G L L + TL ++ V + D I+ CVA + G + L
Sbjct: 3341 PPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 3400
Query: 443 VTGGP--EPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPS---GP 495
V P EP Q GSL G P ++ ++ P+ S GP
Sbjct: 3401 VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP----LVSWMKDGEPLLSQSLEQGP 3456
Query: 496 ELQ-EAISKGTS 506
LQ EA+ G S
Sbjct: 3457 SLQLEAVGAGDS 3468
Score = 98.6 bits (244), Expect = 2e-20
Identities = 112/426 (26%), Positives = 167/426 (39%), Gaps = 82/426 (19%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAHEYHCV 94
L C+ +G+PP ++W +D L + G L + GSL L L + S A Y CV
Sbjct: 3237 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA-----SDAGAYTCV 3291
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPE---SIEVERGGVARFQCLIQGVPEPSISWEHN 151
A N G +R V + Q + ++ G + C ++G P +SW +
Sbjct: 3292 AHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 3350
Query: 152 GTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
G L + R L SG L I+ V D G + CVA AS D TL V +
Sbjct: 3351 GLPL-PLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGVADRNFTLQVQVPPV 3406
Query: 211 LQEPEILSGPQNLTLTVHQTAV-LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
L+ E QN + V + V L C A P PLVSW + DG + + ++
Sbjct: 3407 LEPVEF----QNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLE-----QGP 3456
Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
+L + V SG Y C A RR Q
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------------------------- 3487
Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
+++ P + + Q P LS PG+ C AQG P+ + W
Sbjct: 3488 -----------------LTVMEPPHIEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITW 3529
Query: 390 LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
K+G+ L+ RL +N+ + + V D +Y C+AE+ G+ + S R+ V P
Sbjct: 3530 HKDGQALT-----RLENNSRATRV--LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI 3582
Query: 450 PRPQGP 455
P+GP
Sbjct: 3583 VGPRGP 3588
Score = 97.4 bits (241), Expect = 4e-20
Identities = 120/495 (24%), Positives = 188/495 (37%), Gaps = 102/495 (20%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
+ L C G PP +SW + +++ GVT+ DG + L ++ S A Y CVA
Sbjct: 1903 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVA 1958
Query: 96 QN-------RYGRLVSRQARVQLASLSRFHQHPESIE--VERGGVARFQCLIQGVPEPSI 146
N RYG V+ R+ L P S+ V R C G P P++
Sbjct: 1959 SNVAGSTELRYGLRVNVPPRITL---------PPSLPGPVLVNTPVRLTCNATGAPSPTL 2009
Query: 147 SWEHNGTALNTANHR-VTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
W +G ++ A + + P G +L + S +D G Y CVA + +D Q +
Sbjct: 2010 MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVV- 2064
Query: 205 VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE-GIQVL 263
L++ P IL N+++ +++ LEC + + P P++SW + DGR + G+ +
Sbjct: 2065 ---LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLEPRPGVHL- 2119
Query: 264 DILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHP 322
D L + V +G Y C A N+ G + V WV V
Sbjct: 2120 -SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV-----------WVAPVFPLR 2167
Query: 323 SSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
S T L+ G +C +GV
Sbjct: 2168 ESHT--------------------------------------LTVREGHPTSLSCECRGV 2189
Query: 383 PESRLVWLKNGKVLSPGNNIRLTHNNST---LMLAGVSVEDEAIYQCVAENSTGSNQASA 439
P ++ W K+G+ L PG L H ++ L L + E Y C N G++
Sbjct: 2190 PFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL 2248
Query: 440 RLVV-----TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSG 494
+L V GP P Q + + G PP+ + + +PVG G
Sbjct: 2249 QLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT----VTWERDGQPVGAELG 2304
Query: 495 PELQEAISKGTSEHV 509
+LQ ++G S HV
Sbjct: 2305 LQLQ---NQGQSLHV 2316
Score = 97.4 bits (241), Expect = 4e-20
Identities = 131/596 (21%), Positives = 217/596 (36%), Gaps = 88/596 (14%)
Query: 31 VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
V +P L C PP ++W R+ L+ V+++ G + +P R+ A
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRA--ENAGR 2818
Query: 91 YHCVAQNRYGRLVSRQARVQLAS---LSRFHQHPESIEVERGGVARFQCLIQGVPEPSIS 147
Y C A N G + L L + E + V QC G P P+IS
Sbjct: 2819 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 2878
Query: 148 WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
W NG + + L +L +++ D +Y CVA N A S + TL V
Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG---SAEKLFTLRV-- 2933
Query: 208 LRLLQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDI 265
Q P ++G + +T ++ + L C +HP P V+W + D +++ + G +V +
Sbjct: 2934 ----QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK-DSQALSL-GEEVFLL 2987
Query: 266 LDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLV----QGEPQGPNWVGRVLEH 321
T L + + SG+Y C A ++ Q +LV + P+GP V
Sbjct: 2988 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 3047
Query: 322 PSSL-----------TGAWIWRG----------SRAGGKRLGL----------------- 343
++ T W G + GG+RL +
Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 3107
Query: 344 ---TAPSSMLLPAQLPEFVQWP--QSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
A + L Q+P + P +++S+ GS + TC GVP + WLK+ +
Sbjct: 3108 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 3167
Query: 399 GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPA-- 456
+ L L+ + Y CVAEN+ + + V P R G A
Sbjct: 3168 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-IRSSGVARE 3226
Query: 457 ---CHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNL 513
G G PP + ++ P+G+ GP L+ + G+
Sbjct: 3227 HHVLEGQEVRLDCEADGQPPPD----VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 3282
Query: 514 EPATAYTIHLRAYSAEGASQDSAPIF-----------ASTMGSNLGEALNLPVPLK 558
A AYT + E A + + + T+ S GE + + P++
Sbjct: 3283 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVR 3338
Score = 92.4 bits (228), Expect = 1e-18
Identities = 125/481 (25%), Positives = 181/481 (37%), Gaps = 100/481 (20%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
L L C EG P +SW +D + L P GS+H AA+ + S A Y C A
Sbjct: 1137 LDLNCVAEGNPEPQLSWSKDGVVLQGRG-----PQGSVHFAAIRT-----SDAGRYRCEA 1186
Query: 96 QNRYGRLVSRQARVQLASLSRFHQHPES----IEVERGGVARFQCLIQGVPEPSISWEHN 151
N G V+L L H + +E G A C +G P+P ++W
Sbjct: 1187 SNSAG---VDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKG 1243
Query: 152 GTALNTANHR-VTLLPSGILHITSVSQTDMGTYRCVAWN-VASTRHSQDAQLTLSVGPLR 209
++ V +L G L + SVS D G Y C A N V ST S+ A+L + V P
Sbjct: 1244 PSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST--SRRAKLVVYVPPS- 1300
Query: 210 LLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSW---SRLDGRSIGVEG------- 259
++E N++ Q+ LEC A P P + W ++L G +G G
Sbjct: 1301 -IRED---GRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 1356
Query: 260 --IQVLDILDTG-NLMISDVSVQHSGVYVC-AANRPGTHVR---------------RTAQ 300
+ +LD G +L + SG+Y C A N+ GT R AQ
Sbjct: 1357 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 1416
Query: 301 GVLLVQGE--------------------------PQGPNWV----GRVLEHPSSLTG--- 327
VL + G P GP+ G+VL S G
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476
Query: 328 -----AWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
A+ G +A +L + AP ++ + E L + C A+GV
Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQ-------LLCEARGV 1529
Query: 383 PESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
P + W K+G +L + T L L D +Y C A N+ G+ + + RL
Sbjct: 1530 PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLD 1589
Query: 443 V 443
V
Sbjct: 1590 V 1590
Score = 90.5 bits (223), Expect = 4e-18
Identities = 100/414 (24%), Positives = 162/414 (39%), Gaps = 81/414 (19%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
+ + C V G PP+ +SW +D L L L GS H + S+ L + A + CVA
Sbjct: 3331 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL--HGSGHTLRI-SKVQL-ADAGIFTCVA 3386
Query: 96 QNRYGRLVSRQ--ARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGT 153
+ G + R +VQ+ + + + V RG + C +GVP P +SW +G
Sbjct: 3387 ASPAG-VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGE 3445
Query: 154 ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA--STRHSQDAQLTLSVGPLRLL 211
L + +L L + +V D GTY CVA + A + RH Q L ++
Sbjct: 3446 PLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------LTVM 3491
Query: 212 QEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
+ P I P L+LT L C A P P ++W + DG Q L L+
Sbjct: 3492 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG--------QALTRLENN 3542
Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
+ + V+ +G+Y C A P + ++
Sbjct: 3543 SRATRVLRVRDAGLYTCLAESPAGAIEKSF------------------------------ 3572
Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
R+ + AP +++ P + P FV + PG + C + P ++ W
Sbjct: 3573 ----------RVRVQAPPNIVGP-RGPRFV-----VGLAPG-QLVLECSVEAEPAPKITW 3615
Query: 390 LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
++G VL + + L L +S D Y C A N+ GS + R+ +
Sbjct: 3616 HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 3669
Score = 90.1 bits (222), Expect = 6e-18
Identities = 109/465 (23%), Positives = 172/465 (36%), Gaps = 72/465 (15%)
Query: 35 PLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
PL++ C V P + +R L E + S + R+ + Y C
Sbjct: 443 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEIL-----RASKAEEGTYECT 497
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQ--HPESIEVERGGVARFQCLIQGVPEPSISWEHNG 152
A +R G + +A+ Q+ Q ++ V G A C + G +++W +
Sbjct: 498 AVSRAG---TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW 554
Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
L + RV L L I+ + TD G Y+CVA N +T + L + +
Sbjct: 555 RVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG--------VTRASVWLLVRE 606
Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM 272
P++ + + + C A+ +P P +SWSR S ++ + + G L+
Sbjct: 607 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR---ESQALQEDSRIHVDAQGTLI 663
Query: 273 ISDVSVQHSGVYVC-AANRPGTH----------------------VRRTAQGVLLVQGEP 309
I V+ + +G Y C A N GT V + VL+ +
Sbjct: 664 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASG 723
Query: 310 QGPNWVGRVLEHPSSLTGAWIWRGSRAGGKR-------------------LGLTAPSSML 350
P RV+ + L GS +G R LG + L
Sbjct: 724 VPP---PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780
Query: 351 LPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKN-----GKVLSPGNNIRLT 405
P+ + P+ ++ G SA+ C A G P + W + G L G R
Sbjct: 781 AVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR 840
Query: 406 HNNS-TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
+S L V+ ED+A Y C A N G QA ARL+VTG P
Sbjct: 841 QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 885
Score = 90.1 bits (222), Expect = 6e-18
Identities = 95/421 (22%), Positives = 156/421 (37%), Gaps = 68/421 (16%)
Query: 34 HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP----SRAH 89
HP L C+ G P ISW++D L E G H++A+ L ++
Sbjct: 2178 HPTSLSCECRGVPFPKISWRKDGQPLPGEGA------GLQHVSAVGRLLYLGQAQLAQEG 2231
Query: 90 EYHCVAQNRYGRLVSRQARVQL---ASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSI 146
Y C N G S+ ++++ ++ + P + V + GVA +C G P P++
Sbjct: 2232 TYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTV 2290
Query: 147 SWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVG 206
+WE +G + LH+ G Y CVA N+A R + +L++ V
Sbjct: 2291 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELSVLVP 2349
Query: 207 PLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDIL 266
P L+ + + L+ N+T +H L C A P P + W R G G +
Sbjct: 2350 P-ELIGDLDPLT---NITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLA 2403
Query: 267 DTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
L ++ Q SG+Y C A+ RR N+ VL PS
Sbjct: 2404 GGWMLKMTQTQEQDSGLYSCLASNEAGEARR---------------NFSVEVLVPPSI-- 2446
Query: 327 GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
E + + G +A C G P+ +
Sbjct: 2447 ------------------------------ENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 2476
Query: 387 LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
L W K+G+ L+ G+ ++ + L + ++ Y C+A N+ G +L V
Sbjct: 2477 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 2536
Query: 447 P 447
P
Sbjct: 2537 P 2537
Score = 89.0 bits (219), Expect = 1e-17
Identities = 111/460 (24%), Positives = 174/460 (37%), Gaps = 81/460 (17%)
Query: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHL 75
G+E + +E+ TV +P+ L C+ P +I+W +D + L+P G+ L
Sbjct: 2542 GAEDSADEEVTVTV---NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP-GTHGL 2597
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHP------ESIEVERG 129
L +++ A +Y CV N G V L S P + ++ +
Sbjct: 2598 QILNAQKE---DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654
Query: 130 GVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
+C VP P+I W +G + ++ L +L I +D G Y CVA N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714
Query: 190 VASTRHSQDAQLTLSVGPL------------RLLQEPEILSG-PQNLTLTVHQTAVLECI 236
VA QD + + V P+ L +E E G + + + A L C
Sbjct: 2715 VAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 2773
Query: 237 ATSHPWPLVSWSRLD-GRSIGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTH 294
+ P P ++W R D S G E + +L G L I V +++G Y C A+
Sbjct: 2774 TNAIPPPDLTWYREDQPLSAGDE----VSVLQGGRVLQIPLVRAENAGRYSCKAS----- 2824
Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
G +W+ L L LT P ++
Sbjct: 2825 -------------NEVGEDWLHYEL---------------------LVLTPP---VILGD 2847
Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
E V + ++ S+ C A G P + WL+NG SP +++ + L ++
Sbjct: 2848 TEELV---EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 2904
Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQG 454
V D A Y CVAEN GS + +L PPR G
Sbjct: 2905 TAEVADAASYMCVAENQAGS---AEKLFTLRVQVPPRIAG 2941
Score = 85.1 bits (209), Expect = 2e-16
Identities = 98/436 (22%), Positives = 160/436 (36%), Gaps = 76/436 (17%)
Query: 25 LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
L + A PL L C+ G PP +I W R ++ L+ G + L ++
Sbjct: 2359 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM----LKMTQTQ 2414
Query: 85 PSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH--PESIEVERGGVARFQCLIQGVP 142
+ Y C+A N G R V++ E I+V G A C + G P
Sbjct: 2415 EQDSGLYSCLASNEAGE-ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP 2473
Query: 143 EPSISWEHNGTAL--NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVA--STRHSQ 197
+P ++W +G L A+H + P G+ L + + + G Y C+A N T+H Q
Sbjct: 2474 QPKLTWFKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 2530
Query: 198 DAQLTLSVGPLRLLQEPEILSGPQN-----LTLTVHQTAVLECIATSHPWPLVSWSRLDG 252
L +L P IL G ++ +T+TV+ L C A + P P ++W +
Sbjct: 2531 ----------LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580
Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQG 311
IQ+L T L I + + +G Y C N G V+ VL+
Sbjct: 2581 PFEASRNIQLLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI------- 2631
Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGS 371
P S+ L E + + S
Sbjct: 2632 ----------------------------------PPSISKDDPLGEV--GVKEVKTKVNS 2655
Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENS 431
+ C + VP + W K+G+ ++P + +++ L + V D Y CVA N
Sbjct: 2656 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 2715
Query: 432 TGSNQASARLVVTGGP 447
G + +++ P
Sbjct: 2716 AGEDDQDFNVLIQVPP 2731
Score = 84.7 bits (208), Expect = 2e-16
Identities = 99/399 (24%), Positives = 144/399 (36%), Gaps = 87/399 (21%)
Query: 67 LMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQAR-VQLASLSRFHQHPESIE 125
L+P GSL LA + S Y C A N G R VQ+ + P ++
Sbjct: 1078 LLPSGSLRLAQVQVGDS-----GHYECTASNPAGSASHRYVLGVQVPP--QVQPGPRVLK 1130
Query: 126 VERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRC 185
V G C+ +G PEP +SW +G L P G +H ++ +D G YRC
Sbjct: 1131 VLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG------PQGSVHFAAIRTSDAGRYRC 1184
Query: 186 VAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQN--LTLTVHQTAVLECIATSHPWP 243
A N A DA LR+L+ P + + L + A L C A P P
Sbjct: 1185 EASNSAGV----DAWEV----ELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKP 1236
Query: 244 LVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVL 303
V+W R S + G + +L+ G+L ++ VS SG Y C A R A+ V+
Sbjct: 1237 QVTW-RKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Query: 304 LVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQ 363
V P S+ R G++ ++ +
Sbjct: 1296 YV----------------PPSI---------REDGRKANVSGMA---------------- 1314
Query: 364 SLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPG---------------NNIRLTHNN 408
G S C A G P +VWLK+ +++ RL
Sbjct: 1315 ------GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 1368
Query: 409 STLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
+L + D +Y C AEN G+ Q L+V P
Sbjct: 1369 QSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP 1407
Score = 82.0 bits (201), Expect = 2e-15
Identities = 81/278 (29%), Positives = 116/278 (41%), Gaps = 24/278 (8%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
L L C G P I W + + GV+ GS A SR + Y C A
Sbjct: 4146 LWLRCAARGSPTPRIGWTVNDRPVTE--GVSEQDGGSTLQRAAVSRED----SGTYVCWA 4199
Query: 96 QNRYGRLVSRQARVQLASLSRFHQHPESIEVER-GGVARFQCLIQGVPEPSISWEHNGTA 154
+NR GR + V + S VE GG + C+++G P P I W +G
Sbjct: 4200 ENRVGR-TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 4258
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
L +H L +G L I + D G Y+C+A N + + V L L P
Sbjct: 4259 LR-GSHLRHQLQNGSLTIHRTERDDAGRYQCLAEN--------EMGVAKKVVILVLQSAP 4309
Query: 215 EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
PQ++T+ L C AT P P + W + G+ + + L L G+L +
Sbjct: 4310 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRAS--RRLRTLPDGSLWLE 4366
Query: 275 DVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQG 311
+V +G Y C A N G+ TA+ L+V+GEPQG
Sbjct: 4367 NVETGDAGTYDCVAHNLLGS---ATARAFLVVRGEPQG 4401
Score = 80.1 bits (196), Expect = 6e-15
Identities = 109/452 (24%), Positives = 162/452 (35%), Gaps = 99/452 (21%)
Query: 18 ELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDG-SLHLA 76
+L + LG + PL LPCQ G P +I W ++ +GV + G +LH+
Sbjct: 1689 QLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHID 1748
Query: 77 ALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLA------------SLSRFH---QHP 121
+ S + C A N G + A V+++ + ++H +H
Sbjct: 1749 HVELDHS-----GLFACQATNEAG---TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 1800
Query: 122 ESI------EVERG-GVARFQCLIQGVPEPSISW-EHNGTALNTANHRVTLLPSGILHIT 173
S V RG G L++G P W E G + +L P L I
Sbjct: 1801 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIE 1853
Query: 174 SVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVL 233
V D G Y C A N+A + A L++L P I GP N + + + L
Sbjct: 1854 KVDLRDEGIYTCAATNLAGESKREVA--------LKVLVPPNIEPGPVNKAVLENASVTL 1905
Query: 234 ECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGT 293
EC+A+ P P VSW + G + V +D L I + +G Y C A+
Sbjct: 1906 ECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA- 1962
Query: 294 HVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPA 353
GS L + P + LP
Sbjct: 1963 ---------------------------------------GSTELRYGLRVNVPPRITLPP 1983
Query: 354 QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN--NIRLTHNNSTL 411
LP P ++ P TC A G P L+WLK+G +SP +++ L
Sbjct: 1984 SLP----GPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 2035
Query: 412 MLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
LA D Y CVA ++ G ++ L V
Sbjct: 2036 TLASARASDSGRYSCVAVSAVGEDRQDVVLQV 2067
Score = 73.6 bits (179), Expect = 6e-13
Identities = 106/436 (24%), Positives = 156/436 (35%), Gaps = 88/436 (20%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSR 81
V+ D V V + LPC+ G P +SW +D L ++S L SL L A+ +
Sbjct: 3410 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAG 3466
Query: 82 RSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFH----QHPESIEVERGGVARFQCL 137
S Y CVA + G + QL + H P + + G C
Sbjct: 3467 DS-----GTYSCVAVSEAGEA---RRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 3518
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
QG P+P+I+W +G AL T L + + D G Y C+A + A
Sbjct: 3519 AQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKS 3571
Query: 198 DAQLTLSVGPLRLLQEPEILS--GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
+R+ P I+ GP+ + VLEC + P P ++W R DG I
Sbjct: 3572 FR--------VRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DG--I 3620
Query: 256 GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
++ + G L + +S SG Y C A R A G V
Sbjct: 3621 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA--------RNAAGSTSV--------- 3663
Query: 315 VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
RV H +P P +++ +A+
Sbjct: 3664 AFRVEIH--------------------------------TVPTIRSGPPAVNVSVNQTAL 3691
Query: 375 FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
C A GVP + W K+ L P + +L + V +D Y C+A NS GS
Sbjct: 3692 LPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 3751
Query: 435 NQASARLVVTGGPEPP 450
++ L V EPP
Sbjct: 3752 DRQGRDLRVL---EPP 3764
Score = 66.2 bits (160), Expect = 9e-11
Identities = 114/481 (23%), Positives = 169/481 (35%), Gaps = 90/481 (18%)
Query: 36 LVLPCQVEGEPPVSISWQRDR---------------LALANESGVTLMPDG-SLHLAALP 79
L L C G P I W +D L G L+ +G SLH +
Sbjct: 1318 LTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 1377
Query: 80 SRRS--LPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCL 137
S RA AQ + LV V A + + + G QC
Sbjct: 1378 EGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA------QEVLGLAGADVELQCW 1431
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHS 196
GVP P + W + + + + G +L IT D G Y+CVA++ A + +
Sbjct: 1432 TSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG-QQA 1490
Query: 197 QDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLE--CIATSHPWPLVSWSRLDGRS 254
+D Q LR+ P I + + V + +++ C A P P ++W + DG
Sbjct: 1491 RDFQ-------LRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK-DGAL 1542
Query: 255 IGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAAN----------RPGTHVRRTAQG--- 301
+ +V+ L + +GVY C A+ R +V T +G
Sbjct: 1543 LPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 1601
Query: 302 ----VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRG----------SRAGGKRLGLTAP- 346
V V G P V R HPS T +W G G L L +P
Sbjct: 1602 RPYVVKAVAGRPVALECVAR--GHPSP-TLSWHHEGLPVAESNESRLETDGSVLRLESPG 1658
Query: 347 --SSMLL------PA-----QLPEFVQWPQSLSKPPGSSAIFT---------CVAQGVPE 384
SS L PA Q VQ P L G + T C A G P
Sbjct: 1659 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPV 1718
Query: 385 SRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVT 444
+ WL+NG+ +++ +TL + V ++ ++ C A N G+ A + V
Sbjct: 1719 PTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH 1778
Query: 445 G 445
G
Sbjct: 1779 G 1779
Score = 34.7 bits (78), Expect = 0.28
Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 408 NSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP--PRPQGPACHGSLYFCH 465
NS+ + S +E Y+C A + G+ +A A++VVT P P P G
Sbjct: 478 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 537
Query: 466 SSVLGATP 473
VLG P
Sbjct: 538 CRVLGEAP 545
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 139 bits (349), Expect = 1e-32
Identities = 149/545 (27%), Positives = 216/545 (39%), Gaps = 72/545 (13%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGS-LHLAALPSRRSLPSRAHEYHCV 94
LVL C VE EP I+W RD + L ++ G L L AL + S +Y C
Sbjct: 2317 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-----GDYSCT 2371
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTA 154
A+N G S RV++ ++ P ++ V A C GVP P +SW +
Sbjct: 2372 ARNAAGS-TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2430
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA-STRHSQDAQLTLSVGPLRLLQE 213
L+ + R +LP G L I V D G Y C+A N A S R +D LR+L+
Sbjct: 2431 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD---------LRVLEP 2481
Query: 214 PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ-VLDILDTGNLM 272
P I P NLTLT H A+L C A+ P PLV W + DG+ + Q +L + L+
Sbjct: 2482 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALL 2540
Query: 273 ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ---GEPQGPNWVGRVLE-----HPSS 324
++ Q S + C + R Q + V + Q V + H +
Sbjct: 2541 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600
Query: 325 L---TGAWIWRGSRAGGKRLGL-TAPSSMLLPAQL------------------------- 355
+ T +W G++ G + G +PS L Q
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2660
Query: 356 -----PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNST 410
P P + + C A G+P + W K G ++ G + ++
Sbjct: 2661 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ- 2719
Query: 411 LMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP--EPPRPQGPACHGSLYFCHSSV 468
L +A S ED Y C+A+NS GS RLVV P E P GS F
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2779
Query: 469 LGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSA 528
G+ P+ I + +PV SG E + I + + E + NLE A T A +A
Sbjct: 2780 RGSPEPN----ITWDKDGQPV---SGAEGKFTI-QPSGELLVKNLEGQDAGTYTCTAENA 2831
Query: 529 EGASQ 533
G ++
Sbjct: 2832 VGRAR 2836
Score = 138 bits (348), Expect = 1e-32
Identities = 128/461 (27%), Positives = 194/461 (42%), Gaps = 61/461 (13%)
Query: 30 AVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
AV E ++LPC+ G P +I+WQ++ L +A ++P G L +A + P A
Sbjct: 2677 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIA-----HASPEDAG 2731
Query: 90 EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWE 149
Y C+A+N G + + V + P+ + G A C +G PEP+I+W+
Sbjct: 2732 NYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPCKARGSPEPNITWD 2790
Query: 150 HNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLR 209
+G ++ A + T+ PSG L + ++ D GTY C A N A R + LT+ V P+
Sbjct: 2791 KDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRRVHLTILVLPV- 2848
Query: 210 LLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
+ P + +L + L C A P P + W+ ++ R + EG+ D
Sbjct: 2849 ------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSEQD--GGS 2898
Query: 270 NLMISDVSVQHSGVYVC-AANRPG-------THVRR------------------TAQGVL 303
L + VS + SG YVC A NR G HV+ + Q
Sbjct: 2899 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDC 2958
Query: 304 LVQGEP-QGPNWV-------GRVLEHPSSLTGAWIWRGSRAGGKR--------LGLTAPS 347
+V+G+P +W+ G L H I R R R +G+
Sbjct: 2959 VVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKV 3018
Query: 348 SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHN 407
+L+ P F PQ ++ G C A G P + WL+ G+ L +R T
Sbjct: 3019 VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR-TLP 3077
Query: 408 NSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
+ +L L V D Y CVA N GS A A LVV G P+
Sbjct: 3078 DGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3118
Score = 108 bits (269), Expect = 2e-23
Identities = 139/603 (23%), Positives = 215/603 (35%), Gaps = 99/603 (16%)
Query: 24 ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
E G+ + +H + L C+ G P +I+W +D L + V G L R+
Sbjct: 226 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR----QLQLGRA 281
Query: 84 LPSRAHEYHCVAQNRYGRLVSRQARVQL---ASLSRFHQHPESIEVERGGVARFQCLIQG 140
S A Y C A N G + R+ + ++ P ++ G +C+ +G
Sbjct: 282 QSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 340
Query: 141 VPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQ 200
P P++SW H G + +N +L + S + G Y CVA + A Q
Sbjct: 341 HPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YS 399
Query: 201 LTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
+ + V P L+ E G +T V Q L C A+ P P + W + + + G+
Sbjct: 400 VEVQVPPQLLVAE-----GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 454
Query: 261 QVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
QV T L I V + HSG++ C A N GT A+ + V GE W VL
Sbjct: 455 QVASQGTT--LHIDHVELDHSGLFACQATNEAGT---AGAEVEVSVHGE-----WAPGVL 504
Query: 320 -----------EHPSSLTGA--------------------WIWRGSRAGGKRLGLTAPSS 348
EH SS A W GS G+ G+ S
Sbjct: 505 EVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 563
Query: 349 MLLPAQL---------------------------------PEFVQWPQSLSKPPGSSAIF 375
+ P Q+ P P + + +S
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTL 623
Query: 376 TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
C+A GVP + W K + +S + ++ + L + + D Y+CVA N GS
Sbjct: 624 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 683
Query: 436 QASARLVVTGGPE---PPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEP 492
+ L V P PP GP + + GA P+ + ++ PV
Sbjct: 684 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT----LMWLKDGNPVSPA 739
Query: 493 SGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTMGSNLGEALN 552
P LQ + G ++ + + A SA G + + S LGE LN
Sbjct: 740 GTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN 797
Query: 553 LPV 555
+ V
Sbjct: 798 VSV 800
Score = 102 bits (254), Expect = 1e-21
Identities = 109/416 (26%), Positives = 162/416 (38%), Gaps = 66/416 (15%)
Query: 23 QELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRR 82
+EL +V E + L CQ PP +SW +D L GV L D +L L R
Sbjct: 794 EELNVSVVANES-VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL----LQVDR 848
Query: 83 SLPSRAHEYHCVAQNRYGRLVSR-QARVQLASLSRFHQHPESIEVERGGVARFQCLIQGV 141
+ A Y C A N+ G V +A + + ++ V G R C +GV
Sbjct: 849 ADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRES-HTLTVREGHPTRLSCECRGV 907
Query: 142 PEPSISWEHNGTAL--NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
P P ISW +G L A + +L++ GTY C NV SQD
Sbjct: 908 PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG-NSSQDL 966
Query: 200 QLTLSVGP-LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
QL + V P + +EP P +++ A LEC AT P P V+W R DG+ +G E
Sbjct: 967 QLEVHVPPQIAGPREP-----PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAE 1020
Query: 259 -GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGR 317
G+Q+ + +L + H+G Y C A R + +LV E G
Sbjct: 1021 LGLQLQN--QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD----- 1073
Query: 318 VLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTC 377
L+ +++T A L +P ++L C
Sbjct: 1074 -LDPLTNITAA--------------LHSPLTLL--------------------------C 1092
Query: 378 VAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
A G+P + W + + +SPG + L L + +D +Y C+A N G
Sbjct: 1093 EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 1148
Score = 101 bits (252), Expect = 2e-21
Identities = 113/458 (24%), Positives = 163/458 (35%), Gaps = 64/458 (13%)
Query: 35 PLVLPCQVEGEPPVSISWQRDRLAL---ANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
P +LPC+ G P + W +D L + L+P +L L A P P + ++
Sbjct: 2498 PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTA-PG----PQDSAQF 2552
Query: 92 HCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHN 151
CV N G R +V + V C G+P P++SW
Sbjct: 2553 ECVVSNEVGE-AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2611
Query: 152 GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
G L + PSG L I G Y C A N A H + LT+ P+
Sbjct: 2612 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASPV--- 2667
Query: 212 QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
+ P + + +L C A+ P P ++W + +G ++ G+ +L G L
Sbjct: 2668 ----VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK-EGLNVAT-GVST-QVLPGGQL 2720
Query: 272 MISDVSVQHSGVYVC-AANRPGTHVRRTAQGV----LLVQGEPQGPNWVGRVLEHPSSLT 326
I+ S + +G Y+C A N G+ + +T V ++ G P G P
Sbjct: 2721 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 2780
Query: 327 GA------WIWRGSRAGGKRLGLT-APSSMLLPAQ------------------------- 354
G+ W G G T PS LL
Sbjct: 2781 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2840
Query: 355 -----LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNS 409
LP F P S G C A+G P R+ W N + ++ G + S
Sbjct: 2841 LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQDGGS 2898
Query: 410 TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
TL A VS ED Y C AEN G QA + + V P
Sbjct: 2899 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 2936
Score = 99.8 bits (247), Expect = 7e-21
Identities = 139/552 (25%), Positives = 200/552 (36%), Gaps = 95/552 (17%)
Query: 24 ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
+L A+ + LPC V P ++W +D AL+ V L+P L R+
Sbjct: 1661 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH----TLQLGRA 1716
Query: 84 LPSRAHEYHCVAQNRYGRLVSRQARVQLASL--SRFHQHP----ESIEVERGGVARFQCL 137
S + Y C A N GR Q VQL+ L F Q P +++ V G A C
Sbjct: 1717 RLSDSGMYTCEALNAAGR---DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 1773
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
+PEP+++W +G L A L L I +D G Y C NVA
Sbjct: 1774 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG----- 1828
Query: 198 DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA----VLECIATSHPWPLVSW--SRLD 251
+A T ++ +Q P P+ T TV Q A VL C + P P V+W R+
Sbjct: 1829 EAVRTFTL----TVQVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 1882
Query: 252 GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
S V G+ + G L +S + +G Y C A R+ +LV +
Sbjct: 1883 VESSAVHGV----VSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS 1938
Query: 312 PNWV-------GRVLEHPSSLTG------AWIWRGSRAG---GKRL------------GL 343
G+ + G AW+ GS G G L GL
Sbjct: 1939 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGL 1998
Query: 344 TAPS---------------------SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
A ++L+P + + +L PG C +G
Sbjct: 1999 RASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 2058
Query: 383 PESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
P + WLK+G L L + TL ++ V + D I+ CVA + G + L
Sbjct: 2059 PPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 2118
Query: 443 VTGGP--EPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPS---GP 495
V P EP Q GSL G P ++ ++ P+ S GP
Sbjct: 2119 VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP----LVSWMKDGEPLLSQSLEQGP 2174
Query: 496 ELQ-EAISKGTS 506
LQ EA+ G S
Sbjct: 2175 SLQLEAVGAGDS 2186
Score = 98.6 bits (244), Expect = 2e-20
Identities = 112/426 (26%), Positives = 167/426 (39%), Gaps = 82/426 (19%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAHEYHCV 94
L C+ +G+PP ++W +D L + G L + GSL L L + S A Y CV
Sbjct: 1955 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA-----SDAGAYTCV 2009
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPE---SIEVERGGVARFQCLIQGVPEPSISWEHN 151
A N G +R V + Q + ++ G + C ++G P +SW +
Sbjct: 2010 AHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 2068
Query: 152 GTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
G L + R L SG L I+ V D G + CVA AS D TL V +
Sbjct: 2069 GLPL-PLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGVADRNFTLQVQVPPV 2124
Query: 211 LQEPEILSGPQNLTLTVHQTAV-LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
L+ E QN + V + V L C A P PLVSW + DG + + ++
Sbjct: 2125 LEPVEF----QNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLE-----QGP 2174
Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
+L + V SG Y C A RR Q
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------------------------- 2205
Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
+++ P + + Q P LS PG+ C AQG P+ + W
Sbjct: 2206 -----------------LTVMEPPHIEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITW 2247
Query: 390 LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
K+G+ L+ RL +N+ + + V D +Y C+AE+ G+ + S R+ V P
Sbjct: 2248 HKDGQALT-----RLENNSRATRV--LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI 2300
Query: 450 PRPQGP 455
P+GP
Sbjct: 2301 VGPRGP 2306
Score = 97.4 bits (241), Expect = 4e-20
Identities = 131/596 (21%), Positives = 217/596 (36%), Gaps = 88/596 (14%)
Query: 31 VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
V +P L C PP ++W R+ L+ V+++ G + +P R+ A
Sbjct: 1481 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRA--ENAGR 1536
Query: 91 YHCVAQNRYGRLVSRQARVQLAS---LSRFHQHPESIEVERGGVARFQCLIQGVPEPSIS 147
Y C A N G + L L + E + V QC G P P+IS
Sbjct: 1537 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1596
Query: 148 WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
W NG + + L +L +++ D +Y CVA N A S + TL V
Sbjct: 1597 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG---SAEKLFTLRV-- 1651
Query: 208 LRLLQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDI 265
Q P ++G + +T ++ + L C +HP P V+W + D +++ + G +V +
Sbjct: 1652 ----QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK-DSQALSL-GEEVFLL 1705
Query: 266 LDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLV----QGEPQGPNWVGRVLEH 321
T L + + SG+Y C A ++ Q +LV + P+GP V
Sbjct: 1706 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1765
Query: 322 PSSL-----------TGAWIWRG----------SRAGGKRLGL----------------- 343
++ T W G + GG+RL +
Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 1825
Query: 344 ---TAPSSMLLPAQLPEFVQWP--QSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
A + L Q+P + P +++S+ GS + TC GVP + WLK+ +
Sbjct: 1826 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1885
Query: 399 GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPA-- 456
+ L L+ + Y CVAEN+ + + V P R G A
Sbjct: 1886 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-IRSSGVARE 1944
Query: 457 ---CHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNL 513
G G PP + ++ P+G+ GP L+ + G+
Sbjct: 1945 HHVLEGQEVRLDCEADGQPPPD----VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 2000
Query: 514 EPATAYTIHLRAYSAEGASQDSAPIF-----------ASTMGSNLGEALNLPVPLK 558
A AYT + E A + + + T+ S GE + + P++
Sbjct: 2001 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVR 2056
Score = 97.1 bits (240), Expect = 5e-20
Identities = 120/495 (24%), Positives = 188/495 (37%), Gaps = 102/495 (20%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
+ L C G PP +SW + +++ GVT+ DG + L ++ S A Y CVA
Sbjct: 621 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVA 676
Query: 96 QN-------RYGRLVSRQARVQLASLSRFHQHPESIE--VERGGVARFQCLIQGVPEPSI 146
N RYG V+ R+ L P S+ V R C G P P++
Sbjct: 677 SNVAGSTELRYGLRVNVPPRITL---------PPSLPGPVLVNTPVRLTCNATGAPSPTL 727
Query: 147 SWEHNGTALNTANHR-VTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
W +G ++ A + + P G +L + S +D G Y CVA + +D Q +
Sbjct: 728 MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVV- 782
Query: 205 VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE-GIQVL 263
L++ P IL N+++ +++ LEC + + P P++SW + DGR + G+ +
Sbjct: 783 ---LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLEPRPGVHL- 837
Query: 264 DILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHP 322
D L + V +G Y C A N+ G + V WV V
Sbjct: 838 -SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV-----------WVAPVFPLR 885
Query: 323 SSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
S T L+ G +C +GV
Sbjct: 886 ESHT--------------------------------------LTVREGHPTRLSCECRGV 907
Query: 383 PESRLVWLKNGKVLSPGNNIRLTHNNST---LMLAGVSVEDEAIYQCVAENSTGSNQASA 439
P ++ W K+G+ L PG L H ++ L L + E Y C N G++
Sbjct: 908 PFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL 966
Query: 440 RLVV-----TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSG 494
+L V GP P Q + + G PP+ + + +PVG G
Sbjct: 967 QLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT----VTWERDGQPVGAELG 1022
Query: 495 PELQEAISKGTSEHV 509
+LQ ++G S HV
Sbjct: 1023 LQLQ---NQGQSLHV 1034
Score = 90.5 bits (223), Expect = 4e-18
Identities = 100/414 (24%), Positives = 162/414 (39%), Gaps = 81/414 (19%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
+ + C V G PP+ +SW +D L L L GS H + S+ L + A + CVA
Sbjct: 2049 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL--HGSGHTLRI-SKVQL-ADAGIFTCVA 2104
Query: 96 QNRYGRLVSRQ--ARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGT 153
+ G + R +VQ+ + + + V RG + C +GVP P +SW +G
Sbjct: 2105 ASPAG-VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGE 2163
Query: 154 ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA--STRHSQDAQLTLSVGPLRLL 211
L + +L L + +V D GTY CVA + A + RH Q L ++
Sbjct: 2164 PLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------LTVM 2209
Query: 212 QEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
+ P I P L+LT L C A P P ++W + DG Q L L+
Sbjct: 2210 EPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG--------QALTRLENN 2260
Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
+ + V+ +G+Y C A P + ++
Sbjct: 2261 SRATRVLRVRDAGLYTCLAESPAGAIEKSF------------------------------ 2290
Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
R+ + AP +++ P + P FV + PG + C + P ++ W
Sbjct: 2291 ----------RVRVQAPPNIVGP-RGPRFV-----VGLAPG-QLVLECSVEAEPAPKITW 2333
Query: 390 LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
++G VL + + L L +S D Y C A N+ GS + R+ +
Sbjct: 2334 HRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2387
Score = 89.7 bits (221), Expect = 7e-18
Identities = 95/421 (22%), Positives = 156/421 (37%), Gaps = 68/421 (16%)
Query: 34 HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP----SRAH 89
HP L C+ G P ISW++D L E G H++A+ L ++
Sbjct: 896 HPTRLSCECRGVPFPKISWRKDGQPLPGEGA------GLQHVSAVGRLLYLGQAQLAQEG 949
Query: 90 EYHCVAQNRYGRLVSRQARVQL---ASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSI 146
Y C N G S+ ++++ ++ + P + V + GVA +C G P P++
Sbjct: 950 TYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTV 1008
Query: 147 SWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVG 206
+WE +G + LH+ G Y CVA N+A R + +L++ V
Sbjct: 1009 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELSVLVP 1067
Query: 207 PLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDIL 266
P L+ + + L+ N+T +H L C A P P + W R G G +
Sbjct: 1068 P-ELIGDLDPLT---NITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLA 1121
Query: 267 DTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
L ++ Q SG+Y C A+ RR N+ VL PS
Sbjct: 1122 GGWMLKMTQTQEQDSGLYSCLASNEAGEARR---------------NFSVEVLVPPSI-- 1164
Query: 327 GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
E + + G +A C G P+ +
Sbjct: 1165 ------------------------------ENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1194
Query: 387 LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
L W K+G+ L+ G+ ++ + L + ++ Y C+A N+ G +L V
Sbjct: 1195 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 1254
Query: 447 P 447
P
Sbjct: 1255 P 1255
Score = 89.0 bits (219), Expect = 1e-17
Identities = 111/460 (24%), Positives = 174/460 (37%), Gaps = 81/460 (17%)
Query: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHL 75
G+E + +E+ TV +P+ L C+ P +I+W +D + L+P G+ L
Sbjct: 1260 GAEDSADEEVTVTV---NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP-GTHGL 1315
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHP------ESIEVERG 129
L +++ A +Y CV N G V L S P + ++ +
Sbjct: 1316 QILNAQKE---DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372
Query: 130 GVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
+C VP P+I W +G + ++ L +L I +D G Y CVA N
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432
Query: 190 VASTRHSQDAQLTLSVGPL------------RLLQEPEILSG-PQNLTLTVHQTAVLECI 236
VA QD + + V P+ L +E E G + + + A L C
Sbjct: 1433 VAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1491
Query: 237 ATSHPWPLVSWSRLD-GRSIGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTH 294
+ P P ++W R D S G E + +L G L I V +++G Y C A+
Sbjct: 1492 TNAIPPPDLTWYREDQPLSAGDE----VSVLQGGRVLQIPLVRAENAGRYSCKAS----- 1542
Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
G +W+ L L LT P ++
Sbjct: 1543 -------------NEVGEDWLHYEL---------------------LVLTPP---VILGD 1565
Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
E V + ++ S+ C A G P + WL+NG SP +++ + L ++
Sbjct: 1566 TEELV---EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 1622
Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQG 454
V D A Y CVAEN GS + +L PPR G
Sbjct: 1623 TAEVADAASYMCVAENQAGS---AEKLFTLRVQVPPRIAG 1659
Score = 85.5 bits (210), Expect = 1e-16
Identities = 98/436 (22%), Positives = 160/436 (36%), Gaps = 76/436 (17%)
Query: 25 LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
L + A PL L C+ G PP +I W R ++ L+ G + L ++
Sbjct: 1077 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM----LKMTQTQ 1132
Query: 85 PSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH--PESIEVERGGVARFQCLIQGVP 142
+ Y C+A N G R V++ E I+V G A C + G P
Sbjct: 1133 EQDSGLYSCLASNEAGE-ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHP 1191
Query: 143 EPSISWEHNGTAL--NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVA--STRHSQ 197
+P ++W +G L A+H + P G+ L + + + G Y C+A N T+H Q
Sbjct: 1192 QPKLTWFKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 1248
Query: 198 DAQLTLSVGPLRLLQEPEILSGPQN-----LTLTVHQTAVLECIATSHPWPLVSWSRLDG 252
L +L P IL G ++ +T+TV+ L C A + P P ++W +
Sbjct: 1249 ----------LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298
Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQG 311
IQ+L T L I + + +G Y C N G V+ VL+
Sbjct: 1299 PFEASRNIQLLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI------- 1349
Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGS 371
P S+ L E + + S
Sbjct: 1350 ----------------------------------PPSISKDDPLAEV--GVKEVKTKVNS 1373
Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENS 431
+ C + VP + W K+G+ ++P + +++ L + V D Y CVA N
Sbjct: 1374 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1433
Query: 432 TGSNQASARLVVTGGP 447
G + +++ P
Sbjct: 1434 AGEDDQDFNVLIQVPP 1449
Score = 82.4 bits (202), Expect = 1e-15
Identities = 81/278 (29%), Positives = 116/278 (41%), Gaps = 24/278 (8%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
L L C G P I W + + GV+ GS A SR + Y C A
Sbjct: 2864 LWLRCAARGSPTPRIGWTVNDRPVTE--GVSEQDGGSTLQRAAVSRED----SGTYVCWA 2917
Query: 96 QNRYGRLVSRQARVQLASLSRFHQHPESIEVER-GGVARFQCLIQGVPEPSISWEHNGTA 154
+NR GR + V + S VE GG + C+++G P P I W +G
Sbjct: 2918 ENRVGR-TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 2976
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
L +H L +G L I + D G Y+C+A N + + V L L P
Sbjct: 2977 LR-GSHLRHQLQNGSLTIRRTERDDAGRYQCLAEN--------EMGVAKKVVILVLQSAP 3027
Query: 215 EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
PQ++T+ L C AT P P + W + G+ + + L L G+L +
Sbjct: 3028 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRAS--RRLRTLPDGSLWLE 3084
Query: 275 DVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQG 311
+V +G Y C A N G+ TA+ L+V+GEPQG
Sbjct: 3085 NVETGDAGTYDCVAHNLLGS---ATARAFLVVRGEPQG 3119
Score = 80.1 bits (196), Expect = 6e-15
Identities = 109/452 (24%), Positives = 162/452 (35%), Gaps = 99/452 (21%)
Query: 18 ELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDG-SLHLA 76
+L + LG + PL LPCQ G P +I W ++ +GV + G +LH+
Sbjct: 407 QLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHID 466
Query: 77 ALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLA------------SLSRFH---QHP 121
+ S + C A N G + A V+++ + ++H +H
Sbjct: 467 HVELDHS-----GLFACQATNEAG---TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 518
Query: 122 ESI------EVERG-GVARFQCLIQGVPEPSISW-EHNGTALNTANHRVTLLPSGILHIT 173
S V RG G L++G P W E G + +L P L I
Sbjct: 519 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIE 571
Query: 174 SVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVL 233
V D G Y C A N+A + A L++L P I GP N + + + L
Sbjct: 572 KVDLRDEGIYTCAATNLAGESKREVA--------LKVLVPPNIEPGPVNKAVLENASVTL 623
Query: 234 ECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGT 293
EC+A+ P P VSW + G + V +D L I + +G Y C A+
Sbjct: 624 ECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA- 680
Query: 294 HVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPA 353
GS L + P + LP
Sbjct: 681 ---------------------------------------GSTELRYGLRVNVPPRITLPP 701
Query: 354 QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN--NIRLTHNNSTL 411
LP P ++ P TC A G P L+WLK+G +SP +++ L
Sbjct: 702 SLP----GPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 753
Query: 412 MLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
LA D Y CVA ++ G ++ L V
Sbjct: 754 TLASARASDSGRYSCVAVSAVGEDRQDVVLQV 785
Score = 73.6 bits (179), Expect = 6e-13
Identities = 106/436 (24%), Positives = 156/436 (35%), Gaps = 88/436 (20%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSR 81
V+ D V V + LPC+ G P +SW +D L ++S L SL L A+ +
Sbjct: 2128 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAG 2184
Query: 82 RSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFH----QHPESIEVERGGVARFQCL 137
S Y CVA + G + QL + H P + + G C
Sbjct: 2185 DS-----GTYSCVAVSEAGEA---RRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 2236
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
QG P+P+I+W +G AL T L + + D G Y C+A + A
Sbjct: 2237 AQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKS 2289
Query: 198 DAQLTLSVGPLRLLQEPEILS--GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
+R+ P I+ GP+ + VLEC + P P ++W R DG I
Sbjct: 2290 FR--------VRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DG--I 2338
Query: 256 GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
++ + G L + +S SG Y C A R A G V
Sbjct: 2339 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA--------RNAAGSTSV--------- 2381
Query: 315 VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
RV H +P P +++ +A+
Sbjct: 2382 AFRVEIH--------------------------------TVPTIRSGPPAVNVSVNQTAL 2409
Query: 375 FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
C A GVP + W K+ L P + +L + V +D Y C+A NS GS
Sbjct: 2410 LPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 2469
Query: 435 NQASARLVVTGGPEPP 450
++ L V EPP
Sbjct: 2470 DRQGRDLRVL---EPP 2482
Score = 66.2 bits (160), Expect = 9e-11
Identities = 114/481 (23%), Positives = 169/481 (35%), Gaps = 90/481 (18%)
Query: 36 LVLPCQVEGEPPVSISWQRDR---------------LALANESGVTLMPDG-SLHLAALP 79
L L C G P I W +D L G L+ +G SLH +
Sbjct: 36 LTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 95
Query: 80 SRRS--LPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCL 137
S RA AQ + LV V A + + + G QC
Sbjct: 96 EGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA------QEVLGLAGADVELQCW 149
Query: 138 IQGVPEPSISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHS 196
GVP P + W + + + + G +L IT D G Y+CVA++ A + +
Sbjct: 150 TSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG-QQA 208
Query: 197 QDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLE--CIATSHPWPLVSWSRLDGRS 254
+D Q LR+ P I + + V + +++ C A P P ++W + DG
Sbjct: 209 RDFQ-------LRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK-DGAL 260
Query: 255 IGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAAN----------RPGTHVRRTAQG--- 301
+ +V+ L + +GVY C A+ R +V T +G
Sbjct: 261 LPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 319
Query: 302 ----VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRG----------SRAGGKRLGLTAP- 346
V V G P V R HPS T +W G G L L +P
Sbjct: 320 RPYVVKAVAGRPVALECVAR--GHPSP-TLSWHHEGLPVAESNESRLETDGSVLRLESPG 376
Query: 347 --SSMLL------PA-----QLPEFVQWPQSLSKPPGSSAIFT---------CVAQGVPE 384
SS L PA Q VQ P L G + T C A G P
Sbjct: 377 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPV 436
Query: 385 SRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVT 444
+ WL+NG+ +++ +TL + V ++ ++ C A N G+ A + V
Sbjct: 437 PTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH 496
Query: 445 G 445
G
Sbjct: 497 G 497
Score = 43.5 bits (101), Expect = 6e-04
Identities = 59/241 (24%), Positives = 90/241 (37%), Gaps = 63/241 (26%)
Query: 222 NLTLTVHQTAVLECIATSHPWPLVSW---SRLDGRSIGVEG---------IQVLDILDTG 269
N++ Q+ LEC A P P + W ++L G +G G + +LD G
Sbjct: 27 NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86
Query: 270 -NLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTG 327
+L + SG+Y C A N+ GT R ++ VL PS L
Sbjct: 87 QSLHFPRIQEGDSGLYSCRAENQAGTAQR----------------DFHLLVLTPPSVL-- 128
Query: 328 AWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRL 387
G+ A + LGL G+ C GVP ++
Sbjct: 129 -----GAGAAQEVLGLA-------------------------GADVELQCWTSGVPTPQV 158
Query: 388 VWLKNGKVLSPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
W K+ + + PG ++++ + L + G V DE YQCVA + G +L V
Sbjct: 159 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 218
Query: 447 P 447
P
Sbjct: 219 P 219
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 139 bits (349), Expect = 1e-32
Identities = 142/506 (28%), Positives = 207/506 (40%), Gaps = 91/506 (17%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
V+ D + P L C+ EG P +I W + + + S L+P GSL L
Sbjct: 71 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 130
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL-SRFHQHPESIEVERGGVARF 134
+ R+S P Y CVA+N G VS A +++A L F Q+P + V G A
Sbjct: 131 RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 189
Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C +G PEP+ISW+ +G+ L+ + R+T+ G L IT ++D G Y CV N+
Sbjct: 190 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 248
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
R S+ A+LT+ L+ P + P NL +TV +A +C A P P V W + DG
Sbjct: 249 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 301
Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
+I D L I V+ G Y C A N G + A L VQ EP P
Sbjct: 302 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQ-EP--P 351
Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
++V GR + TG A WR SR + G
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
L S++ A L P Q P + + +
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
+ +CVA G P ++W K+G ++S ++ N L + + D Y C+A +
Sbjct: 472 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 531
Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
G SA + V G P +PPRP P
Sbjct: 532 GEATWSAYIEVQEFGVPVQPPRPTDP 557
Score = 100 bits (249), Expect = 4e-21
Identities = 97/347 (27%), Positives = 139/347 (40%), Gaps = 76/347 (21%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
R +HP + V +G A C +G P P+I W G + T +HR+ LLPSG L
Sbjct: 69 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 127
Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
+ S+ D G Y CVA N S +A L +++ + P ++ +
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 181
Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
V + AV+EC HP P +SW + DG + + ++ + G LMI+ +G Y
Sbjct: 182 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 238
Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
VC G N VG + LT
Sbjct: 239 VCV-----------------------GTNMVGERESEVAELT------------------ 257
Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
+ P FV+ P +L+ SA F C A+G P + W K +G++ IR
Sbjct: 258 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 310
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
H TL + V+ D Y CVAEN G +ASA L V EPP
Sbjct: 311 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV---QEPP 351
Score = 93.2 bits (230), Expect = 7e-19
Identities = 81/309 (26%), Positives = 129/309 (41%), Gaps = 24/309 (7%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
+FV+ + + C+ G+P ++ W++D L +S + D +L +
Sbjct: 263 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 317
Query: 80 SRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQ 139
R+ Y CVA+N G+ A + + F P V G FQC
Sbjct: 318 -RKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 375
Query: 140 GVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAS 192
G P+P+I W G+ ++ R ++ +G L IT+V ++D+G Y C NVA
Sbjct: 376 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 435
Query: 193 TRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDG 252
+ ++ V R P I GP N T+ V T VL C+AT P P + W R DG
Sbjct: 436 SIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDG 492
Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLLVQ 306
+ + ++ L+ G L I + +G Y C A+ P +A GV +
Sbjct: 493 VLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 551
Query: 307 GEPQGPNWV 315
P PN +
Sbjct: 552 PRPTDPNLI 560
Score = 39.7 bits (91), Expect = 0.009
Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)
Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
P V+ P L G A C A+G P + W K G+ + P ++ L + S
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
L V S DE +Y CVA N G S+ AS + +
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 167
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 135 bits (341), Expect = 9e-32
Identities = 164/616 (26%), Positives = 229/616 (37%), Gaps = 139/616 (22%)
Query: 2 GLLLLLLPGWGCAA-----GSELA-------FVQELGDTVAVWEHPLVLPCQVEGEPPVS 49
GLL++ + WG GS L V+ D + P L C+ EG P +
Sbjct: 18 GLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT 77
Query: 50 ISWQRDRLALANE-----SGVTLMPDGSLH-LAALPSRRSLPSRAHEYHCVAQNRYGRLV 103
I W +D + + S L+P GSL L + RRS P Y CVA+N G V
Sbjct: 78 IEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEG-SYVCVARNYLGEAV 136
Query: 104 SRQARVQLASL-SRFHQHPESIEVERGGVARFQCL-IQGVPEPSISWEHNGTALNTANHR 161
SR A +++A L F Q+P + V G A +C +G PEP+I W+ + ++ R
Sbjct: 137 SRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEER 196
Query: 162 VTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQ 221
++ + G L I++ ++D G Y CV N+ R S A+LT + + P L P
Sbjct: 197 IS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELT-------VFERPTFLRRPI 248
Query: 222 NLTLTVHQTAVLECIATSHPWPLVSWSRLD-----GRSIGVEGIQVLDILDTGNLMISDV 276
N + + C P P V W + D GR DI D L I
Sbjct: 249 NQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR---------YDIKDDYTLRIKKT 299
Query: 277 SVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQ---GPN----WVGRVLEHPSSLTG- 327
G Y+C A NR G + A L V+ PQ P GR + P G
Sbjct: 300 MSTDEGTYMCIAENRVG---KMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGN 356
Query: 328 ---AWIWR----------------GSRAGGKRLG-------------------LTAPSSM 349
A W+ SR G LT S+
Sbjct: 357 PQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSI 416
Query: 350 LLPAQL-----------PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
L AQL P +Q P + + +A+ C A G P + WLK G P
Sbjct: 417 LAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-P 475
Query: 399 GNNIRLT-HNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPAC 457
G + R T TL + + + D Y CVA +S+G SA L VT
Sbjct: 476 GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTES----------- 524
Query: 458 HGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPAT 517
GAT + D+ G PS P++ + T V + +P T
Sbjct: 525 ------------GATISKNYDLSDL------PGPPSKPQVTDV----TKNSVTLSWQPGT 562
Query: 518 AYTIHLRAYSAEGASQ 533
T+ AY E SQ
Sbjct: 563 PGTLPASAYIIEAFSQ 578
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 135 bits (340), Expect = 1e-31
Identities = 154/612 (25%), Positives = 227/612 (37%), Gaps = 96/612 (15%)
Query: 6 LLLPGWGCAAGSELA-------FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRD--R 56
LL PG GS + V++ D + P LPC+ EG P +I W ++ R
Sbjct: 44 LLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGAR 103
Query: 57 LALANESGVT---LMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLAS 113
+A E L+P G+L + R Y CVA+N G SR A +++A
Sbjct: 104 VATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV 163
Query: 114 L-SRFHQHPESIEVERGGVARFQCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILH 171
L F Q P ++ V G A +C+ +G PEPS+SW +G L R+T+ G L
Sbjct: 164 LRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLM 222
Query: 172 ITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA 231
++ ++D G Y CVA N+A R S A++ + L+ P L P N +
Sbjct: 223 MSHTLKSDAGMYVCVASNMAGERESAAAEVMV-------LERPSFLRRPVNQVVLADAPV 275
Query: 232 VLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANR- 290
C P P + W + DG +I +L I VS + G Y C A
Sbjct: 276 TFLCEVKGDPPPRLRWRKEDGELPTGR----YEIRSDHSLWIGHVSAEDEGTYTCVAENS 331
Query: 291 ----------------------------PGTHV----------------RRTAQGVLLVQ 306
PG V ++ VLL
Sbjct: 332 VGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391
Query: 307 GEPQGPNWVGRVLEHP-SSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQL---------- 355
+ P GR P L + RG ++ S+L A L
Sbjct: 392 SQSLQPT--GRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGL 449
Query: 356 -PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
P +Q P + + GSS C G P+ + W K+G+ L + T N TL +A
Sbjct: 450 PPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIA 509
Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVVTG----GPEPPR-----PQGPACHGSLYFCH 465
V D Y CVA++STG S L + P+PP P P+
Sbjct: 510 NVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITK 569
Query: 466 SSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGT--SEHVFSNLEPATAYTIHL 523
+S+ P+ + ++ P+ ++ G H S L+P T Y +
Sbjct: 570 NSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629
Query: 524 RAYSAEGASQDS 535
RA A G S+ S
Sbjct: 630 RAVGAWGLSEPS 641
Score = 114 bits (286), Expect = 2e-25
Identities = 125/451 (27%), Positives = 175/451 (38%), Gaps = 88/451 (19%)
Query: 113 SLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTAN-----HRVTLLPS 167
++ R + P + V RG A C +G P P+I W NG + T HR+ LLPS
Sbjct: 62 AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL-LLPS 120
Query: 168 GILHITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQN 222
G L + ++ D G Y CVA N S++A L ++V + P N
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV------LRDDFRQSPGN 174
Query: 223 LTLTVHQTAVLECIAT-SHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHS 281
+ + V + AVLEC+ HP P VSW R DG + E ++ + G LM+S +
Sbjct: 175 VVVAVGEPAVLECVPPRGHPEPSVSW-RKDGARLKEEEGRIT--IRGGKLMMSHTLKSDA 231
Query: 282 GVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRL 341
G+YVC A+ A V+ VLE PS L
Sbjct: 232 GMYVCVASNMAGERESAAAEVM--------------VLERPSFLR--------------- 262
Query: 342 GLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN- 400
P + ++ A P F C +G P RL W K L G
Sbjct: 263 ---RPVNQVVLADAP----------------VTFLCEVKGDPPPRLRWRKEDGELPTGRY 303
Query: 401 NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE---PPRPQGPAC 457
IR H+ L + VS EDE Y CVAENS G +AS L V P+ P+ Q A
Sbjct: 304 EIRSDHS---LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360
Query: 458 HGSLYFCHSSVLGATPPS-------SRDIIGYVLHLRPVG----EPSGPELQEAISKGTS 506
S+ F G PP+ S+ ++ L+P G P G A+ +G +
Sbjct: 361 GESVAF-QCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419
Query: 507 EHVFSNLEPATAYTIHLRAYSAEGASQDSAP 537
+ + +GAS D P
Sbjct: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLP 450
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 134 bits (336), Expect = 3e-31
Identities = 156/584 (26%), Positives = 218/584 (37%), Gaps = 127/584 (21%)
Query: 22 VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
V+ D + P L C+ EG P +I W +D + + S L+P GSL L
Sbjct: 34 VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFL 93
Query: 76 AALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL-SRFHQHPESIEVERGGVARF 134
+ RRS P Y CVA+N G VSR A +++A L F Q+P + V G A
Sbjct: 94 RIVHGRRSKPDEG-SYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAIL 152
Query: 135 QCL-IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C +G PEP+I W+ + ++ R++ + G L I++ ++D G Y CV N+
Sbjct: 153 ECQPPRGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGE 211
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLD-- 251
R S A+LT + + P L P N + + C P P V W + D
Sbjct: 212 RDSDPAELT-------VFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264
Query: 252 ---GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQG 307
GR DI D L I G Y+C A NR G + A L V+
Sbjct: 265 LPRGR---------YDIKDDYTLRIKKTMSTDEGTYMCIAENRVG---KMEASATLTVRA 312
Query: 308 EPQ---GPN----WVGRVLEHPSSLTG----AWIWR----------------GSRAGGKR 340
PQ P GR + P G A W+ SR
Sbjct: 313 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 372
Query: 341 LG-------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPG 370
G LT S+L AQL P +Q P + +
Sbjct: 373 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432
Query: 371 SSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLT-HNNSTLMLAGVSVEDEAIYQCVAE 429
+A+ C A G P + WLK G PG + R T TL + + + D Y CVA
Sbjct: 433 GTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQEQGTLQIKNLRISDTGTYTCVAT 491
Query: 430 NSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPV 489
+S+G SA L VT GAT + D+
Sbjct: 492 SSSGETSWSAVLDVTES-----------------------GATISKNYDLSDL------P 522
Query: 490 GEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQ 533
G PS P++ + T V + +P T T+ AY E SQ
Sbjct: 523 GPPSKPQVTDV----TKNSVTLSWQPGTPGTLPASAYIIEAFSQ 562
Score = 107 bits (267), Expect = 3e-23
Identities = 77/275 (28%), Positives = 135/275 (49%), Gaps = 18/275 (6%)
Query: 21 FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
F++ + V + E + CQV+G+P ++ W++D L + D +L +
Sbjct: 227 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-GRYDIKDDYTLRI----- 280
Query: 81 RRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQG 140
++++ + Y C+A+NR G++ + A + + + +F P V +G F C +G
Sbjct: 281 KKTMSTDEGTYMCIAENRVGKMEA-SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKG 339
Query: 141 VPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
P+P++ W+ G+ N R ++ P+G L IT++ ++D G Y C A VA +
Sbjct: 340 NPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGS 399
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
++ AQL ++ L P IL GP N TL V TA+L+C AT P P++SW +
Sbjct: 400 ILAK-AQLEVT-DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFT 457
Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA 288
G + I + G L I ++ + +G Y C A
Sbjct: 458 FPGRD--PRATIQEQGTLQIKNLRISDTGTYTCVA 490
Score = 92.8 bits (229), Expect = 9e-19
Identities = 102/409 (24%), Positives = 158/409 (38%), Gaps = 83/409 (20%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
R +HP + V +G C +G P P+I W +G + T +HR+ LLPSG L
Sbjct: 32 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRM-LLPSGSL 90
Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
+ S+ D G+Y CVA N S++A L ++ L + P ++ +
Sbjct: 91 FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVA------LLRDDFRQNPTDVVV 144
Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
+ A+LEC HP P + W + + ++ + + G LMIS+ +G+Y
Sbjct: 145 AAGEPAILECQPPRGHPEPTIYWKK---DKVRIDDKEERISIRGGKLMISNTRKSDAGMY 201
Query: 285 VCAA-----------------NRPGTHVRRTAQGVLL----------VQGEPQ------- 310
C RP T +RR V+L VQG+PQ
Sbjct: 202 TCVGTNMVGERDSDPAELTVFERP-TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Query: 311 ------------GPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEF 358
++ R+ + S+ G ++ R+G S+ L P+F
Sbjct: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMC----IAENRVGKMEASATLTVRAPPQF 316
Query: 359 VQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNG--KVLSPG-----NNIRLTHNNSTL 411
V P+ G + F C +G P+ + W K G +L P N+ L
Sbjct: 317 VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 376
Query: 412 MLAGVSVEDEAIYQCVAENSTGSNQASARL----VVTGGPEPPRPQGPA 456
+ + D Y C A GS A A+L V+T P P QGPA
Sbjct: 377 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425
Score = 49.7 bits (117), Expect = 9e-06
Identities = 75/305 (24%), Positives = 115/305 (37%), Gaps = 61/305 (20%)
Query: 201 LTLSVGPLRLLQE---PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV 257
L + V RL QE P I+ P ++ ++ + L C A P P + W + DG +
Sbjct: 15 LYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVET 73
Query: 258 EGIQVLD---ILDTGNLMISDV-----SVQHSGVYVCAA-NRPGTHVRRTAQ-------- 300
+ +L +G+L + S G YVC A N G V R A
Sbjct: 74 DKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD 133
Query: 301 -------GVLLVQGEP-----QGPN--------W------VGRVLEHPSSLTGAWIWRGS 334
V++ GEP Q P W + E S G + +
Sbjct: 134 DFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 193
Query: 335 RAGGKRLGLTAPSSML-----LPAQL-----PEFVQWPQSLSKPPGSSAIFTCVAQGVPE 384
R + ++M+ PA+L P F++ P + + F C QG P+
Sbjct: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253
Query: 385 SRLVWLKNGKVLSPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
+ W K+ L G +I+ ++ TL + DE Y C+AEN G +ASA L V
Sbjct: 254 PTVRWKKDDADLPRGRYDIK---DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
Query: 444 TGGPE 448
P+
Sbjct: 311 RAPPQ 315
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 127 bits (319), Expect = 3e-29
Identities = 96/329 (29%), Positives = 136/329 (41%), Gaps = 57/329 (17%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALN-TANHRVTLLPSGILHITS 174
R P+ +V G F C +G P+P I W N L+ + R+ LL G L I +
Sbjct: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQN 306
Query: 175 VSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLE 234
+TD G Y+C+A NVA +Q+ L P R P + PQN + V ++ LE
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPAR----PTFVIQPQNTEVLVGESVTLE 362
Query: 235 CIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTH 294
C AT HP P +SW+R D + V+ ++I +G L I +V SG Y C+A
Sbjct: 363 CSATGHPPPRISWTRGDRTPLPVD--PRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS 420
Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
V TA ++VQ PQ
Sbjct: 421 VHATA--FIIVQALPQ-------------------------------------------- 434
Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
F PQ G + F C A+G P + W K G LS L ++ TL ++
Sbjct: 435 ---FTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRR-HLVLSSGTLRIS 490
Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVV 443
GV++ D+ Y+C A N GS + A L V
Sbjct: 491 GVALHDQGQYECQAVNIIGSQKVVAHLTV 519
Score = 110 bits (275), Expect = 4e-24
Identities = 99/409 (24%), Positives = 169/409 (41%), Gaps = 69/409 (16%)
Query: 40 CQVEGEPPVSISWQRDR--LALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
C+ EG P I W R+ L++ +S + L+ DG+L + + + + Y C+A+N
Sbjct: 267 CRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMI-----QNTQETDQGIYQCMAKN 321
Query: 98 RYGRLVSRQARVQ-LASLSR--FHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTA 154
G + +++ ++ S +R F P++ EV G +C G P P ISW
Sbjct: 322 VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRT 381
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
+ RV + PSG L+I +V Q D G Y C A N + H+ + ++ P
Sbjct: 382 PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQAL--------P 433
Query: 215 EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
+ PQ+ + QT +C A +P P+++W++ G + V+ + +L +G L IS
Sbjct: 434 QFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK-GGSQLSVDRRHL--VLSSGTLRIS 490
Query: 275 DVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGS 334
V++ G Y C Q V ++ + +V+ H +
Sbjct: 491 GVALHDQGQYEC-------------QAVNIIGSQ--------KVVAHLT----------- 518
Query: 335 RAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGK 394
+ P P F P + G++ C +QG PE + W K+G
Sbjct: 519 ---------------VQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGV 563
Query: 395 VLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
++ ++ L + V D Y+CVA N+ GS S L V
Sbjct: 564 QVTESGKFHIS-PEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 99.8 bits (247), Expect = 7e-21
Identities = 82/269 (30%), Positives = 118/269 (43%), Gaps = 17/269 (6%)
Query: 21 FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANESGVTLMPDGSLHLAALP 79
FV + +T + + L C G PP ISW R DR L + V + P G L++
Sbjct: 344 FVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYI---- 399
Query: 80 SRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQ 139
+ + + EY C A N V A + + +L +F P+ V G FQC +
Sbjct: 400 -QNVVQGDSGEYACSATNNIDS-VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAK 457
Query: 140 GVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
G P P I+W G+ L + + R +L SG L I+ V+ D G Y C A N+ SQ
Sbjct: 458 GNPPPVIAWTKGGSQL-SVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG---SQKV 513
Query: 200 QLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEG 259
L+V P P S P + T+ V L C + P P ++W++ DG + G
Sbjct: 514 VAHLTVQP---RVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK-DGVQVTESG 569
Query: 260 IQVLDILDTGNLMISDVSVQHSGVYVCAA 288
I G L I+DV +G Y C A
Sbjct: 570 --KFHISPEGFLTINDVGPADAGRYECVA 596
Score = 68.6 bits (166), Expect = 2e-11
Identities = 51/180 (28%), Positives = 76/180 (42%), Gaps = 10/180 (5%)
Query: 27 DTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPS 86
D V + + C+ +G PP I+W + L+ + ++ G+L ++ +
Sbjct: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQ--- 497
Query: 87 RAHEYHCVAQNRYG-RLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPS 145
+Y C A N G + V VQ F P VE G + C QG PEP+
Sbjct: 498 --GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPA 555
Query: 146 ISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSV 205
I+W +G + T + + + P G L I V D G Y CVA N T S + LSV
Sbjct: 556 ITWNKDGVQV-TESGKFHISPEGFLTINDVGPADAGRYECVARN---TIGSASVSMVLSV 611
Score = 62.4 bits (150), Expect = 1e-09
Identities = 85/371 (22%), Positives = 133/371 (35%), Gaps = 86/371 (23%)
Query: 103 VSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRV 162
+ RQA LASL + + H IE Q +P+ + HN +R+
Sbjct: 125 IDRQAFKGLASLEQLYLHFNQIETLDPDS------FQHLPKLERLFLHN--------NRI 170
Query: 163 T-LLPSGILHITSVSQT--DMGTYRC---VAW------NVASTRHSQDAQL--------- 201
T L+P H+ S+ + D T C + W A + ++Q A +
Sbjct: 171 THLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQG 230
Query: 202 --TLSVGPLRL-LQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
++ P L + P I S PQ+ +T T C A +P P + W R + + ++
Sbjct: 231 RSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR-NNNELSMK 289
Query: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
L++LD G LMI + G+Y C A V+ T + L G P P
Sbjct: 290 TDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPT----- 343
Query: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCV 378
FV PQ+ G S C
Sbjct: 344 ---------------------------------------FVIQPQNTEVLVGESVTLECS 364
Query: 379 AQGVPESRLVWLKNGKVLSPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQA 437
A G P R+ W + + P + + +T + L + V D Y C A N+ S A
Sbjct: 365 ATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNIDSVHA 423
Query: 438 SARLVVTGGPE 448
+A ++V P+
Sbjct: 424 TAFIIVQALPQ 434
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 6/80 (7%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
LPC +GEP +I+W +D + + + P+G L + + P+ A Y CVA+N
Sbjct: 544 LPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVG-----PADAGRYECVARN 598
Query: 98 RYGRL-VSRQARVQLASLSR 116
G VS V + +SR
Sbjct: 599 TIGSASVSMVLSVNVPDVSR 618
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
[Homo sapiens]
Length = 1030
Score = 126 bits (316), Expect = 7e-29
Identities = 116/446 (26%), Positives = 179/446 (40%), Gaps = 42/446 (9%)
Query: 27 DTVAVWEHPLVLPCQVEGEPPVSISWQ-RDRLALANESG------VTLMPDGSLHLAALP 79
D V + CQ +PP S+ W D + N S T+ +GSL L +
Sbjct: 233 DVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVR 292
Query: 80 SRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLI- 138
P A Y C+ Q + G + +A + LA + + G R CL
Sbjct: 293 -----PRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRV-FTAGSEERVTCLPP 346
Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
+G+PEPS+ WEH G L T H L + +++++D G Y C A N+A R QD
Sbjct: 347 KGLPEPSVWWEHAGVRLPT--HGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRR-QD 403
Query: 199 AQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
+T++ P L PQ+ L + L+C+ + P P V W R + +
Sbjct: 404 VNITVAT-------VPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYR---NQMLIS 453
Query: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
++ G L I+ V V Y C ++ P + A+ V ++ G P WV
Sbjct: 454 EDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQAR-VQVLDGSSL-PEWV--- 508
Query: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSM------LLPAQLPEFVQWPQSLSKPPGSS 372
++ +L A + R + P L A F P+ + G +
Sbjct: 509 TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHT 568
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSP---GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAE 429
A+ C AQG P+ + W ++L P G + + N S L++ V+ ED Y C+A
Sbjct: 569 ALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGS-LVIHDVAPEDSGRYTCIAG 627
Query: 430 NSTGSNQASARLVVTGGPEPPRPQGP 455
NS A L V P P +GP
Sbjct: 628 NSCNIKHTEAPLYVVDKPVPEESEGP 653
Score = 87.0 bits (214), Expect = 5e-17
Identities = 113/515 (21%), Positives = 196/515 (38%), Gaps = 93/515 (18%)
Query: 3 LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
L +LLLP G + + F+++ A+ +L C+VE PV + W D A +
Sbjct: 17 LSVLLLPLLG-GTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDG-APVQD 74
Query: 63 SGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSR------ 116
+ SL AA+ + + + CVA++ + +AR AS +
Sbjct: 75 TERRFAQGSSLSFAAVDRLQD----SGTFQCVARDD---VTGEEARSANASFNIKWIEAG 127
Query: 117 --FHQHPES-IEVERGGVARFQCLIQGVPEPSISWEHNGTALN--TANHRV-------TL 164
+HP S E++ +C I G P P+ W +GT L+ +NH V TL
Sbjct: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTL 187
Query: 165 LPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLT 224
P+G H G Y C A + A + TLS+ + ++ PQ++
Sbjct: 188 RPAGPEH--------SGLYSCCA-HSAFGQACSSQNFTLSIADESFAR---VVLAPQDVV 235
Query: 225 LTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEG----IQVLDILDTGNLMISDVSVQH 280
+ ++ A+ C ++ P P + W D I ++ + G+L+++ V ++
Sbjct: 236 VARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRN 295
Query: 281 SGVYVCAAN------------------------RPGTHVRRTAQGV--LLVQGEPQGPNW 314
+G+Y C P + + V L +G P+ W
Sbjct: 296 AGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVW 355
Query: 315 ----------VGRVLEHPSSL---------TGAWIWRGSRAGGKRLGLTAPSSMLLPAQL 355
GRV + L G + + G+R + A +
Sbjct: 356 WEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQR----RQDVNITVATV 411
Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAG 415
P +++ PQ G C+ Q P+ +VW +N ++S + + N TL +
Sbjct: 412 PSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEV-FKNGTLRINS 470
Query: 416 VSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
V V D Y+C++ GS +A AR+ V G P
Sbjct: 471 VEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
Score = 33.5 bits (75), Expect = 0.63
Identities = 32/114 (28%), Positives = 47/114 (41%), Gaps = 9/114 (7%)
Query: 332 RGSRAGGKRLGLTAPSSMLLPA-----QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
RGS A +RL L S +LLP F++ P S G A+ C +
Sbjct: 5 RGSPARPRRLPLL--SVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVH 62
Query: 387 LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVA-ENSTGSNQASA 439
+ WL +G + R +S A ++D +QCVA ++ TG SA
Sbjct: 63 VYWLLDGAPVQDTER-RFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSA 115
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 122 bits (306), Expect = 1e-27
Identities = 116/445 (26%), Positives = 177/445 (39%), Gaps = 73/445 (16%)
Query: 19 LAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAAL 78
+A E D + + L C+ + PP I+W R+ L V ++ G L
Sbjct: 3622 IAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRY----L 3677
Query: 79 PSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLI 138
+ Y CVA N G+ +R+ + + P+S+ + +C+
Sbjct: 3678 QINNADLGDTANYTCVASNIAGK-TTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIA 3736
Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST-RHSQ 197
+GVP P I+W +G L + R ++L +G LHI S TD G Y C+A N A T R
Sbjct: 3737 EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRI 3796
Query: 198 DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV 257
D Q+ + P I GP N+T+ V+ L C AT P P ++W R +G + V
Sbjct: 3797 DLQVHV---------PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINW-RKNGHLLNV 3846
Query: 258 EGIQ-VLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG 316
+ Q +L +G+L+I SV + Y C +RT V
Sbjct: 3847 DQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRT----------------VD 3890
Query: 317 RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFT 376
++ P S+ P+ L+ P A+ T
Sbjct: 3891 LTVQVPPSIA-----------------DEPTDFLVTKHAP----------------AVIT 3917
Query: 377 CVAQGVPESRLVWLKNG-KVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
C A GVP + W KNG ++L G+ R+ + + +LA + Y CVA N+ GS
Sbjct: 3918 CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILA-TQLNHAGRYTCVARNAAGSA 3976
Query: 436 QASARLVVTGGPEPP--RPQGPACH 458
L V EPP +PQ H
Sbjct: 3977 HRHVTLHV---HEPPVIQPQPSELH 3998
Score = 119 bits (298), Expect = 9e-27
Identities = 124/480 (25%), Positives = 192/480 (40%), Gaps = 77/480 (16%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANES-GVTLMPDGSLHLAAL 78
+ E D + P V+ C G P SI W ++ + L G ++ G++ + A
Sbjct: 3898 SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957
Query: 79 PSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLI 138
+ A Y CVA+N G R + + P + V C
Sbjct: 3958 QL-----NHAGRYTCVARNAAGS-AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEA 4011
Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
G P P I+W+ G +NT+ +LPSG L I+ + D GTY CVA N A T
Sbjct: 4012 TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGT----- 4066
Query: 199 AQLTLSVGPLRL-LQEPEILSGP-QNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIG 256
++G ++L +Q P ++S + + V + L C A P P ++W + DGR+I
Sbjct: 4067 -----ALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHK-DGRAI- 4119
Query: 257 VEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTH--------------------- 294
VE I+ +L +G+L I+ V +G Y C AAN G+
Sbjct: 4120 VESIR-QRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHY 4178
Query: 295 -VRRTAQGVL--LVQGEP-QGPNW----------VGRVLEHPSSL----------TGAWI 330
V +Q +L + G P NW +G+ P +G +
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYT 4238
Query: 331 WRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWL 390
+ A G+ + L LP F + P +S G +C A G+P +L W
Sbjct: 4239 CVANNAAGE----DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWT 4294
Query: 391 KNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
N ++ + + +S L++ VS ED Y C AENS G +A + V EPP
Sbjct: 4295 FNNNIIPA--HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYV---KEPP 4349
Score = 116 bits (290), Expect = 7e-26
Identities = 114/424 (26%), Positives = 174/424 (41%), Gaps = 80/424 (18%)
Query: 35 PLVLPCQVEGEPPVSISW-QRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHC 93
P+ LPC+ G P S+ W ++ L + + + DGSL++ + S EY C
Sbjct: 997 PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEES-----GEYVC 1051
Query: 94 VAQNRYGRLVSRQARVQLASLSR----------FHQHPESIEVERGGVARFQCLIQGVPE 143
A N G + +VQL R P I V G C ++ +P
Sbjct: 1052 TATNTAGYA---KRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPP 1108
Query: 144 PSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTL 203
P I+W ++ + R T LPSG + IT +D G Y CVA N+A +Q +L +
Sbjct: 1109 PIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAG-NVTQAVKLNV 1167
Query: 204 SVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVL 263
V P+I GP++L + V Q + C A P P+++WS+ G ++ V+G +
Sbjct: 1168 HV-------PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSK-GGSTMLVDGEHHV 1219
Query: 264 DILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHP 322
D G L I + +G+Y C A N GT + L VQ P + LE P
Sbjct: 1220 SNPD-GTLSIDQATPSDAGIYTCVATNIAGTD---ETEITLHVQEPPTVED-----LEPP 1270
Query: 323 SSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
+ T R +R+ F C A+G
Sbjct: 1271 YNTTFQ-----ERVANQRIE--------------------------------FPCPAKGT 1293
Query: 383 PESRLVWLKNGKVLS---PGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASA 439
P+ + WL NG+ L+ PG I + + + L++A V+ D Y CVA N G+ +
Sbjct: 1294 PKPTIKWLHNGRELTGREPG--ISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKY 1351
Query: 440 RLVV 443
L V
Sbjct: 1352 NLKV 1355
Score = 115 bits (288), Expect = 1e-25
Identities = 102/403 (25%), Positives = 156/403 (38%), Gaps = 67/403 (16%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
L C+V G PP +SW ++ + + ++P G L R+ S EY C+A N
Sbjct: 2984 LTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGR----TLQIIRAKVSDGGEYTCIAIN 3039
Query: 98 RYGRLVSRQARVQLASLSRFHQHPES---IEVERGGVARFQCLIQGVPEPSISWEHNGTA 154
+ G + + S ES + V G +C VP P I+W NG
Sbjct: 3040 QAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRM 3099
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
+ + H L +LHI +D G Y C A NVA R ++ L + V P
Sbjct: 3100 ITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAG-RDDKNFHLNVYV--------P 3150
Query: 215 EILSGPQN--LTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM 272
+ GP+ + T+ L C AT P P ++W + R + ++V + L
Sbjct: 3151 PSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQ 3210
Query: 273 ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWR 332
I+ SG Y C A+ ++G+ Q ++ ++ P S+ GA I
Sbjct: 3211 IARSQHSDSGNYTCIASN--------------MEGKAQKYYFLS--IQVPPSVAGAEI-- 3252
Query: 333 GSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKN 392
P +S G + C A G+P + WLK+
Sbjct: 3253 -----------------------------PSDVSVLLGENVELVCNANGIPTPLIQWLKD 3283
Query: 393 GKVLSPG--NNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
GK ++ G IR++ N STL + G D Y CVA N G
Sbjct: 3284 GKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAG 3326
Score = 115 bits (287), Expect = 2e-25
Identities = 109/459 (23%), Positives = 178/459 (38%), Gaps = 75/459 (16%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
L C+V+G PP +++W +D L GV ++ +G + L + S Y CVA N
Sbjct: 2312 LECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHI----LQLKNIHVSDTGRYVCVAVN 2367
Query: 98 RYGRLVSRQARVQLA--SLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTAL 155
G + A S+ H+ PE+I V C G+P PSI+W +G +
Sbjct: 2368 VAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPV 2427
Query: 156 NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPE 215
+ +N L +L + + D G Y CV N A + L +L P
Sbjct: 2428 SLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK--------IFGLSVLVPPH 2479
Query: 216 ILSGP--QNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGN-LM 272
I+ +++ + Q+ L C T +P P ++W + DG+ + + + I+ G L
Sbjct: 2480 IVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK-DGQPLQED--EAHHIISGGRFLQ 2536
Query: 273 ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ------GEPQGPNWVGRVLEHPSSL- 325
I++V V H+G Y C A+ P H R+ + V G P V +L P+SL
Sbjct: 2537 ITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLV 2596
Query: 326 ---------TGAWIWRGSRAGGKRLGLTAPSS---MLLPAQ------------------- 354
T W G+ R P +L AQ
Sbjct: 2597 CEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMI 2656
Query: 355 --------LPEFVQ----W-----PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLS 397
+P + W P+ + ++ C A +P + L W K+G+ L
Sbjct: 2657 KHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLK 2716
Query: 398 PGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
+++ + N TL + + D Y CVA N G ++
Sbjct: 2717 SDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDE 2755
Score = 112 bits (279), Expect = 1e-24
Identities = 123/477 (25%), Positives = 189/477 (39%), Gaps = 85/477 (17%)
Query: 37 VLPCQVEGEPPVSISWQRDRLALA-NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
VL C EG P I+W++D LA N + +++ +G LH+ + + + Y C+A
Sbjct: 3731 VLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQS-----AHVTDTGRYLCMA 3785
Query: 96 QNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTAL 155
N G R+ +Q+ P ++ V C G+P+PSI+W NG L
Sbjct: 3786 TNAAGT-DRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLL 3844
Query: 156 NTANHRVT--LLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQE 213
N ++ + LL SG L I S S D TY C N A + LT+ V
Sbjct: 3845 NVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD-DKRTVDLTVQV-------P 3896
Query: 214 PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLD------ILD 267
P I P + +T H AV+ C A+ P+P + W++ GI++L IL
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTK--------NGIRLLPRGDGYRILS 3948
Query: 268 TGNLMISDVSVQHSGVYVCAA-NRPGT---HVRRTAQGVLLVQGEPQGPNWV-GRVLEHP 322
+G + I + H+G Y C A N G+ HV ++Q +P + + + P
Sbjct: 3949 SGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLP 4008
Query: 323 SSLTGA------WIWRG--------------------SRA---------------GGKRL 341
TG W G SRA G L
Sbjct: 4009 CEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTAL 4068
Query: 342 GLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNN 401
G + + P P ++ ++ KP +C A G+P + W K+G+ +
Sbjct: 4069 GKIKLNVQVPPVISPHLKEYVIAVDKP----ITLSCEADGLPPPDITWHKDGRAIVESIR 4124
Query: 402 IRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACH 458
R+ + S L +A V D Y C+A N GS+ S +L V PPR + H
Sbjct: 4125 QRVLSSGS-LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV---HVPPRIRSTEGH 4177
Score = 109 bits (272), Expect = 9e-24
Identities = 143/602 (23%), Positives = 228/602 (37%), Gaps = 90/602 (14%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGV-TLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
+ LPC+V+ PP I+W ++ ++ S T +P GS+ + + S + Y CV
Sbjct: 1097 VTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKIT-----ETRTSDSGMYLCV 1151
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTA 154
A N G V++ ++ + + + P+ ++V+ G C QG P P I+W G+
Sbjct: 1152 ATNIAGN-VTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGST 1210
Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
+ P G L I + +D G Y CVA N+A T + ++TL V QEP
Sbjct: 1211 MLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGT---DETEITLHV------QEP 1261
Query: 215 ---EILSGPQNLTL---TVHQTAVLECIATSHPWPLVSW----SRLDGRSIGVEGIQVLD 264
E L P N T +Q C A P P + W L GR G+
Sbjct: 1262 PTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGIS------ 1315
Query: 265 ILDTGNLM-ISDVSVQHSGVYVCAA-NRPGTHVRR-----------------TAQGVLL- 304
IL+ G L+ I+ V+ +G Y+C A N GT R+ T VLL
Sbjct: 1316 ILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLN 1375
Query: 305 --------VQGEPQGP-NWVGRVLEHPSSLTGAWIWRGS-------------RAGGKRLG 342
V+G P W ++ S T + G R K +
Sbjct: 1376 QLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAIN 1435
Query: 343 LTAPSS------MLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL 396
+ S +L+P + +P +S C +G P + W K+GK L
Sbjct: 1436 IAGTSQKYFNIDVLVPPTIIG-TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPL 1494
Query: 397 SPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGP 455
G+ N+ L L L D+ YQC N+ G +L + PP +G
Sbjct: 1495 FLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIY---IPPSIKGG 1551
Query: 456 ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEA-ISKGTSEHV-FSNL 513
+ +S++ +R + + G+P Q I KG H+ + +
Sbjct: 1552 NVTTDISVLINSLI-KLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQV 1610
Query: 514 EPATAYTIHLRAYSAEGASQDSAPIFASTM-GSNLGEALNLPVPLKACLS-QCDLAPEPA 571
+ YT H+ + ++ M NL LN V + L+ +C A P+
Sbjct: 1611 SDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670
Query: 572 AL 573
+
Sbjct: 1671 PI 1672
Score = 108 bits (269), Expect = 2e-23
Identities = 117/461 (25%), Positives = 182/461 (39%), Gaps = 77/461 (16%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
+ C+ G PP I+W ++ L L S + L+ G + + R+ S Y CVA N
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQV----IRIVRAQVSDVAVYTCVASN 3417
Query: 98 RYGRLVSRQARVQLASLSRFHQH--PESIEVERGGVARFQCLIQGVPEPSISWEHNGTAL 155
R G + ++ +Q+ + E I V +G C+ G P PS++W +G L
Sbjct: 3418 RAG-VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPL 3476
Query: 156 NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAS--TRHSQDAQLTLSVGPLRLLQE 213
H +L + D G Y C+A N A ++H L++L+
Sbjct: 3477 GLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHF----------ILKVLEP 3526
Query: 214 PEILSGPQN--LTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
P I ++ +++ V+ L CIA+ P P ++W + DGR + + QV + L
Sbjct: 3527 PHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMK-DGRPL-PQTDQVQTLGGGEVL 3584
Query: 272 MISDVSVQHSGVYVCAANRPG----------THVRRTAQGVLLVQGEPQGPNWVGR---V 318
IS V+ +G Y C A+ P HV G EP+ +
Sbjct: 3585 RISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGT----DEPRDITVLRNRQVT 3640
Query: 319 LEHPSSLTG----AWIWRGSR----------AGGKRL---------------------GL 343
LE S W+ G R +GG+ L G
Sbjct: 3641 LECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGK 3700
Query: 344 TAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIR 403
T +L P PQSL S + C+A+GVP R+ W K+G VL+ GN+ R
Sbjct: 3701 TTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA-GNHAR 3759
Query: 404 LT-HNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
+ N L + V D Y C+A N+ G+++ L V
Sbjct: 3760 YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV 3800
Score = 105 bits (263), Expect = 1e-22
Identities = 110/454 (24%), Positives = 172/454 (37%), Gaps = 65/454 (14%)
Query: 25 LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
L + V + P+ L C+ +G PP I+W +D A+ ++ GSL +A +
Sbjct: 4085 LKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQ----- 4139
Query: 85 PSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEP 144
P A Y C+A N G S ++ + R V A C+ G+P P
Sbjct: 4140 PGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTP 4198
Query: 145 SISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
+I+W+ + L + T P G L + +V D G Y CVA N A + LT+
Sbjct: 4199 AINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAG-EDTHTVSLTVH 4257
Query: 205 VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLD 264
V P P +++L + L C AT P P ++W+ + +
Sbjct: 4258 V-------LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN----IIPAHFDS 4306
Query: 265 ILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEP-----QGPNWVGRV- 318
+ L+I VS + SG YVC A V+ A G + V+ P NW+ +
Sbjct: 4307 VNGHSELVIERVSKEDSGTYVCTAENSVGFVK--AIGFVYVKEPPVFKGDYPSNWIEPLG 4364
Query: 319 --------LEHPSSLTGAWIWRG---------SRAGGKRLGL------------------ 343
++ + T W +G + G L +
Sbjct: 4365 GNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424
Query: 344 --TAPSSMLLPAQLPEFVQW-PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN 400
SM L Q P + P G I C A G P+ + W + G +S +
Sbjct: 4425 AGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDD 4484
Query: 401 NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
+ + NNS L +A ED + ++CVA N GS
Sbjct: 4485 RVNVLSNNS-LYIADAQKEDTSEFECVARNLMGS 4517
Score = 103 bits (257), Expect = 5e-22
Identities = 121/503 (24%), Positives = 188/503 (37%), Gaps = 90/503 (17%)
Query: 16 GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANE----SGVTLMPD 70
GS F+QE D + LPC V+G P +I W+R D + + + S ++ +
Sbjct: 790 GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRT 849
Query: 71 GSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASL--SRFHQHPESIEVER 128
G+L + L S Y C A+N++G++ S + V + L P V
Sbjct: 850 GALFILNL-----WASDKGTYICEAENQFGKIQS-ETTVTVTGLVAPLIGISPSVANVIE 903
Query: 129 GGVARFQC-LIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVA 187
G C L+ G P P W N +A+ N +T+ G LHI V D G Y CVA
Sbjct: 904 GQQLTLPCTLLAGNPIPERRWIKN-SAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVA 962
Query: 188 WNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSW 247
NVA T + + + + P I G Q L+ L C A+ +P P V W
Sbjct: 963 SNVAGTNNKTTSVVVHVL--------PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIW 1014
Query: 248 SRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ- 306
S+ G I + D G+L + + SG YVC A + +R Q + V+
Sbjct: 1015 SK-KGELISTSSAKFSAGAD-GSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRP 1072
Query: 307 ---GEPQG--------------------------------------------------PN 313
G+ +G P+
Sbjct: 1073 RVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPS 1132
Query: 314 WVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ-WPQSLSKPPGSS 372
++ E +S +G ++ + G ++ L +P +Q P+ L G
Sbjct: 1133 GSMKITETRTSDSGMYLCVATNIAG-----NVTQAVKLNVHVPPKIQRGPKHLKVQVGQR 1187
Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
C AQG P + W K G + +++ + TL + + D IY CVA N
Sbjct: 1188 VDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIA 1247
Query: 433 GSNQASARLVVTGGP-----EPP 450
G+++ L V P EPP
Sbjct: 1248 GTDETEITLHVQEPPTVEDLEPP 1270
Score = 102 bits (255), Expect = 9e-22
Identities = 105/425 (24%), Positives = 170/425 (40%), Gaps = 72/425 (16%)
Query: 25 LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
L +TV V +P+ L C+ G P I+W +D L+ + +T + G + + +
Sbjct: 1928 LNETVLV-SNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI----IDIESAQ 1982
Query: 85 PSRAHEYHCVAQNRYGR---LVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGV 141
S A Y CVA N G S Q V S+S + + V R +C +G+
Sbjct: 1983 ISDAGIYKCVAINSAGATELFYSLQVHVA-PSISGSNN---MVAVVVNNPVRLECEARGI 2038
Query: 142 PEPSISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQ 200
P PS++W +G+ +++ ++ + +L G IL +TS +D G Y CVA N A +
Sbjct: 2039 PAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDI-- 2096
Query: 201 LTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
LR+ P I+ QN+++ + Q L C + + P P ++W + + G+
Sbjct: 2097 ------DLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGL 2150
Query: 261 QVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLE 320
+ + + L I D VQ +G Y C A V G+ + V
Sbjct: 2151 SISE--NRSVLKIEDAQVQDTGRYTCEATN--------------VAGKTEKNYNVN---- 2190
Query: 321 HPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQ 380
IW GG E Q L+ G+ C +
Sbjct: 2191 ---------IWVPPNIGGS----------------DELTQ----LTVIEGNLISLLCESS 2221
Query: 381 GVPESRLVWLKNGK-VLSPG-NNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQAS 438
G+P L+W K G VL+ +R+ L ++ D A+Y CVA N G+ +
Sbjct: 2222 GIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKE 2281
Query: 439 ARLVV 443
L V
Sbjct: 2282 YNLQV 2286
Score = 98.2 bits (243), Expect = 2e-20
Identities = 116/475 (24%), Positives = 176/475 (37%), Gaps = 105/475 (22%)
Query: 34 HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHC 93
+P+ L C+ PP +++W +D L + V ++P G + L R+ A Y C
Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRV----LQIPRAKVEDAGRYTC 2848
Query: 94 VAQNRYGR-LVSRQARVQLASLSRFHQH--PESIEVERGGVARFQCLIQGVPEPSISWEH 150
VA N G + RV + + + PE + V A +CL G P P SW+
Sbjct: 2849 VAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK 2908
Query: 151 NGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
+G L +H L IL I + TD+G Y CVA N A S L+V
Sbjct: 2909 DGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAG---SAKKYFNLNV----- 2960
Query: 211 LQEPEILSGP--QNLTLTVHQTAVLECIATSHPWPLVSW------SRLDGRSIGVEGIQV 262
P + GP +NLT+ V+ L C + P P +SW +L+ ++ V G +
Sbjct: 2961 -HVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRT 3019
Query: 263 LDIL--------------------------------------DTGNLMISDVSVQHSGVY 284
L I+ D+ +L + +V S
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSL 3079
Query: 285 VCAAN----------------RPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
C +N THV A G +L + + S TG
Sbjct: 3080 ECESNAVPPPVITWYKNGRMITESTHVEILADGQML------------HIKKAEVSDTGQ 3127
Query: 329 WIWRGSRAGGK-----RLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVP 383
++ R G+ L + P S+ + PE +++S P TC A G+P
Sbjct: 3128 YVCRAINVAGRDDKNFHLNVYVPPSI----EGPEREVIVETISNP----VTLTCDATGIP 3179
Query: 384 ESRLVWLKNGKVL--SPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
+ WLKN K + S +R+ S L +A D Y C+A N G Q
Sbjct: 3180 PPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQ 3234
Score = 95.1 bits (235), Expect = 2e-19
Identities = 111/479 (23%), Positives = 179/479 (37%), Gaps = 96/479 (20%)
Query: 24 ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
EL + + + L C+ G PP ++ W++ G ++ D + L R
Sbjct: 2202 ELTQLTVIEGNLISLLCESSGIPPPNLIWKK--------KGSPVLTDSMGRVRILSGGRQ 2253
Query: 84 LP------SRAHEYHCVAQNRYGRLVSRQARVQL---ASLSRFHQHPESIEVERGGVARF 134
L S A Y CVA N G ++ +Q+ +++ HP I V RG
Sbjct: 2254 LQISIAEKSDAALYSCVASNVAGT-AKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISL 2312
Query: 135 QCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTR 194
+C +QG+P P+++W +G L A L IL + ++ +D G Y CVA NVA
Sbjct: 2313 ECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAG-- 2370
Query: 195 HSQDAQLTLSVGPLRLLQEPEILS---GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLD 251
D + LSV P I+ P+N+++ + L C A+ P P ++W + D
Sbjct: 2371 -MTDKKYDLSVH-----APPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFK-D 2423
Query: 252 GRSIGVEGIQVLDILDTGNLM-ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQ 310
G + + + IL G ++ + +++ +G Y C R+ +LV
Sbjct: 2424 GWPVSLS--NSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIV 2481
Query: 311 GPNWVG--RVLEHPS-----SLTG------AWIWRGSR----------AGGKRLGLTAPS 347
G N + +V E S +TG W G +GG+ L +T
Sbjct: 2482 GENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQIT--- 2538
Query: 348 SMLLPAQLPEFVQWPQSLSKPPG---------------------------------SSAI 374
Q+P ++ S P G S
Sbjct: 2539 ----NVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS 2594
Query: 375 FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
C A P + + W K+G L NIR+ TL + ++ Y CVA N G
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Score = 93.6 bits (231), Expect = 5e-19
Identities = 98/441 (22%), Positives = 165/441 (37%), Gaps = 67/441 (15%)
Query: 27 DTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPS 86
D + P L C+ PP +I+W +D L + + ++P G L +
Sbjct: 2584 DVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR----TLQILNAQED 2639
Query: 87 RAHEYHCVAQNRYGRLVSR-QARVQLASLSRFHQ------HPESIEVERGGVARFQCLIQ 139
A Y CVA N G ++ + +V + + P+ ++++ +C
Sbjct: 2640 NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699
Query: 140 GVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
+P S+SW +G L + +H L I +D G Y CVA N+A D
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG-EDELDF 2758
Query: 200 QLTLSVGP--LRLLQEPEILSGPQN---LTLTVHQTAVLECIATSHPWPLVSWSRLDGRS 254
+ + V P +L + +L +N + ++ L C + P P ++W + DG
Sbjct: 2759 DVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYK-DGHP 2817
Query: 255 IGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
+ +VL + L I V+ +G Y C A V + L +
Sbjct: 2818 L-TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA------VNEAGEDSL---------QY 2861
Query: 315 VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
RVL P I +G+ + P+ ++ SA+
Sbjct: 2862 DVRVLVPP-------IIKGANS-----------------------DLPEEVTVLVNKSAL 2891
Query: 375 FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
C++ G P R W K+G+ L ++ + N L + + D Y CVAEN+ GS
Sbjct: 2892 IECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS 2951
Query: 435 NQASARLVVTGGPEPPRPQGP 455
+ L V PP GP
Sbjct: 2952 AKKYFNLNV---HVPPSVIGP 2969
Score = 92.8 bits (229), Expect = 9e-19
Identities = 98/427 (22%), Positives = 161/427 (37%), Gaps = 85/427 (19%)
Query: 36 LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
L L C+ P S+SW +D L ++ V + +G L + + S Y CVA
Sbjct: 2692 LTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH----TLQIKEAQISDTGRYTCVA 2747
Query: 96 QNRYGR-LVSRQARVQLA-SLSRFHQHPESIEVERGGVAR---------FQCLIQGVPEP 144
N G + +Q+ S + + ++ R G A+ C P P
Sbjct: 2748 SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPP 2807
Query: 145 SISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQ-DAQLT 202
+++W +G L T++ +V +LP G +L I D G Y CVA N A Q D ++
Sbjct: 2808 TLTWYKDGHPL-TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866
Query: 203 LSVGPLRLLQEPEILSG-----PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV 257
+ P I+ G P+ +T+ V+++A++EC+++ P P SW + DG+ +
Sbjct: 2867 V----------PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK-DGQPLLE 2915
Query: 258 EGIQVLDILDTGNLM-ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG 316
+ L G ++ I + + G YVC A
Sbjct: 2916 DDHH--KFLSNGRILQILNTQITDIGRYVCVAENTA------------------------ 2949
Query: 317 RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFT 376
GS L + P S++ P ++L+ + T
Sbjct: 2950 ----------------GSAKKYFNLNVHVPPSVIGPKS--------ENLTVVVNNFISLT 2985
Query: 377 CVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
C G P L WLKN + + N + TL + V D Y C+A N G ++
Sbjct: 2986 CEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESK 3045
Query: 437 ASARLVV 443
L V
Sbjct: 3046 KKFSLTV 3052
Score = 90.5 bits (223), Expect = 4e-18
Identities = 110/472 (23%), Positives = 188/472 (39%), Gaps = 70/472 (14%)
Query: 31 VWEHPLVLPCQVEGEPPVSISWQRDRLAL-ANESGVTLMPDGS-LHLAALPSRRSLPSRA 88
V + L CQV+G P I W +D L + V L+ G LHL +RR+ R
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKN--ARRNDKGR- 1522
Query: 89 HEYHCVAQNRYGRLVSR-QARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSIS 147
Y C N G+ + + + + I V + + +C +G+P P+I+
Sbjct: 1523 --YQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAIT 1580
Query: 148 WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
W +G + +++ + + LHI +D TY C NVA T + + + V P
Sbjct: 1581 WYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTA-EKSFHVDVYVPP 1639
Query: 208 LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV-EGIQVLDIL 266
+ L+ P N + + + LEC A +P P+++W + DG + + I++
Sbjct: 1640 M----IEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK-DGVPVKANDNIRI---- 1690
Query: 267 DTGNLMISDVSVQH--SGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPN-------WVGR 317
+ G + +S Q G Y+C A + +LV +G + V
Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNN 1750
Query: 318 VLEHPSSLTGA------WIWRG---SRAGGKRLGLTAPSSMLLPAQL------------- 355
+LE +TG+ W+ G G ++ L ++ AQ+
Sbjct: 1751 LLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANT 1810
Query: 356 -----PEF---VQWPQSLSKPPGSSAI--------FTCVAQGVPESRLVWLKNGK-VLSP 398
EF V P ++ S + C+A G+P + WLK+ + V +
Sbjct: 1811 AGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTA 1870
Query: 399 GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
N+++ + L +A +ED Y CVA N+ G Q +L V EPP
Sbjct: 1871 QGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHV---HEPP 1919
Score = 90.1 bits (222), Expect = 6e-18
Identities = 103/423 (24%), Positives = 156/423 (36%), Gaps = 88/423 (20%)
Query: 37 VLPCQVEGEPPVSISWQR-DR-LALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
VL C + +++WQR DR + LA + + + + SL L ++ + A EYHC
Sbjct: 538 VLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF-----NDAGEYHC- 591
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQHPESIEV-------ERGGVARFQCLIQGVPEPSIS 147
+VS + AS+ Q P + V G C G P+P I+
Sbjct: 592 -------MVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIA 644
Query: 148 WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
W N + +HR + G L I + + D G Y C+A N A T
Sbjct: 645 WTVNDMFI-VGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNST-------- 695
Query: 208 LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILD 267
LR ++ P+++ L + + V+EC + P P V W + D + ++D L
Sbjct: 696 LRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGD-LELRPSTFLIIDPL- 753
Query: 268 TGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTG 327
G L I + +G Y C A
Sbjct: 754 LGLLKIQETQDLDAGDYTCVA--------------------------------------- 774
Query: 328 AWIWRGSRAGGK-RLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
I RA GK L + +P P F+Q P +S GS+ C QG PE
Sbjct: 775 --INEAGRATGKITLDVGSP---------PVFIQEPADVSMEIGSNVTLPCYVQGYPEPT 823
Query: 387 LVW--LKNGKVLSPGNNIRLTHNNST--LMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
+ W L N + S ++ T L + + D+ Y C AEN G Q+ +
Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT 883
Query: 443 VTG 445
VTG
Sbjct: 884 VTG 886
Score = 86.7 bits (213), Expect = 6e-17
Identities = 99/432 (22%), Positives = 156/432 (36%), Gaps = 70/432 (16%)
Query: 34 HPLVLPCQVEGEPPVSISWQRDRLALANESG--VTLMPDGSLHLAALPSRRSLPSRAHEY 91
+P+ L C G PP +I+W ++ + N V ++ GS L RS S + Y
Sbjct: 3167 NPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGS----KLQIARSQHSDSGNY 3222
Query: 92 HCVAQNRYGRLVSRQ-ARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEH 150
C+A N G+ +Q+ + P + V G C G+P P I W
Sbjct: 3223 TCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLK 3282
Query: 151 NGTALNTAN-HRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPL 208
+G + + R+ + +G L+I +D G Y CVA N A + L + V P
Sbjct: 3283 DGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAG-EEDRIFNLNVYVTPT 3341
Query: 209 RLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
+ E + L V + +EC AT P P ++W + + + + +L
Sbjct: 3342 IRGNKDEA----EKLMTLVDTSINIECRATGTPPPQINWLK---NGLPLPLSSHIRLLAA 3394
Query: 269 GNLM-ISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
G ++ I V VY C A+NR G + L V P N +G
Sbjct: 3395 GQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYN---LQVFAPPNMDNSMGT--------- 3442
Query: 327 GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
+ ++ GSS C+ G P
Sbjct: 3443 ------------------------------------EEITVLKGSSTSMACITDGTPAPS 3466
Query: 387 LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
+ WL++G+ L ++ ++ + L L ED Y C+A N G L V
Sbjct: 3467 MAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL-- 3524
Query: 447 PEPPRPQGPACH 458
EPP G H
Sbjct: 3525 -EPPHINGSEEH 3535
Score = 84.0 bits (206), Expect = 4e-16
Identities = 96/413 (23%), Positives = 148/413 (35%), Gaps = 70/413 (16%)
Query: 37 VLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQ 96
V+ C+ G PP + W + L L L+ D L L + + L A +Y CVA
Sbjct: 720 VMECKTSGIPPPQVKWFKGDLEL--RPSTFLIIDPLLGLLKIQETQDLD--AGDYTCVAI 775
Query: 97 NRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGT--- 153
N GR + + + S F Q P + +E G C +QG PEP+I W
Sbjct: 776 NEAGRATGK-ITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 834
Query: 154 -ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
+ + ++ L +G L I ++ +D GTY C A N S+ L
Sbjct: 835 FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG------LV 888
Query: 213 EPEILSGPQNLTLTVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
P I P + Q L C + +P P W + S + + + G+L
Sbjct: 889 APLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK---NSAMLLQNPYITVRSDGSL 945
Query: 272 MISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWI 330
I V +Q G Y C A+N GT+ + T+ V+ H
Sbjct: 946 HIERVQLQDGGEYTCVASNVAGTNNKTTS------------------VVVH--------- 978
Query: 331 WRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWL 390
LP Q LS G C A G P+ ++W
Sbjct: 979 -----------------------VLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWS 1015
Query: 391 KNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
K G+++S + + +L + E+ Y C A N+ G + +L V
Sbjct: 1016 KKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068
Score = 83.2 bits (204), Expect = 7e-16
Identities = 91/420 (21%), Positives = 154/420 (36%), Gaps = 70/420 (16%)
Query: 34 HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH---- 89
H L L C+ G P ++W +D GV + + ++ + A + + S
Sbjct: 1657 HSLTLECKAAGNPSPILTWLKD--------GVPVKANDNIRIEAGGKKLEIMSAQEIDRG 1708
Query: 90 EYHCVAQNRYG-RLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISW 148
+Y CVA + G + + + V + V + C + G P P+I W
Sbjct: 1709 QYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMW 1768
Query: 149 EHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPL 208
+G ++ + LL L I ++ G YRC+A N A H ++ ++T+ V P
Sbjct: 1769 LKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD-HKKEFEVTVHVPPT 1827
Query: 209 RLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
SG + ++ L+CIA P P ++W + D +G L I +
Sbjct: 1828 IK------SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG--NLKIQSS 1879
Query: 269 GN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTG 327
G L I+ ++ +G Y C A T Q + L EP G++L ++
Sbjct: 1880 GRVLQIAKTLLEDAGRYTCVATNA---AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSN 1936
Query: 328 AWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRL 387
P QL C A G P +
Sbjct: 1937 ------------------------PVQL--------------------ECKAAGNPVPVI 1952
Query: 388 VWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
W K+ ++LS ++ + + + + D IY+CVA NS G+ + L V P
Sbjct: 1953 TWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAP 2012
Score = 82.4 bits (202), Expect = 1e-15
Identities = 96/450 (21%), Positives = 173/450 (38%), Gaps = 66/450 (14%)
Query: 39 PCQVEGEPPVSISWQRD-RLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
PC +G P +I W + R E G++++ DG+L + A + P EY CVA N
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVT----PYDNGEYICVAVN 1342
Query: 98 RYGRLVSR-QARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALN 156
G + +V + + + + ++ V + C ++G P P I W + +
Sbjct: 1343 EAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT 1402
Query: 157 TANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEI 216
++ T+ IL + + D G Y C A N+A T +Q ++ +L P I
Sbjct: 1403 ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT-----SQKYFNID---VLVPPTI 1454
Query: 217 L--SGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM-I 273
+ + P +++ +++ LEC P+P + W + DG+ + + G +++LD G ++ +
Sbjct: 1455 IGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFK-DGKPLFL-GDPNVELLDRGQVLHL 1512
Query: 274 SDVSVQHSGVYVC----AANRPGTHVRRT-------------------AQGVLLVQGEPQ 310
+ G Y C AA + ++ T ++ ++ E +
Sbjct: 1513 KNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETR 1572
Query: 311 G-----PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGL---------------TAPSSML 350
G W SS +I +G R + TA S
Sbjct: 1573 GLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFH 1632
Query: 351 LPAQLPEFVQ----WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTH 406
+ +P ++ P + S C A G P L WLK+G + +NIR+
Sbjct: 1633 VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEA 1692
Query: 407 NNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
L + D Y CVA + G +
Sbjct: 1693 GGKKLEIMSAQEIDRGQYICVATSVAGEKE 1722
Score = 81.3 bits (199), Expect = 3e-15
Identities = 100/425 (23%), Positives = 151/425 (35%), Gaps = 86/425 (20%)
Query: 25 LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESG-VTLMPDGSLHLAALPSRRS 83
L + V V P+ L C G P SI+W +D + G + + G + L ++
Sbjct: 1833 LSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV----LQIAKT 1888
Query: 84 LPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH-PESIE---------VERGGVAR 133
L A Y CVA N G Q +QL H H P S+E V +
Sbjct: 1889 LLEDAGRYTCVATNAAGET---QQHIQL------HVHEPPSLEDAGKMLNETVLVSNPVQ 1939
Query: 134 FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
+C G P P I+W + L+ + L I+ I S +D G Y+CVA N A
Sbjct: 1940 LECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999
Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
+L S L++ P I + + V+ LEC A P P ++W + DG
Sbjct: 2000 -----TELFYS---LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLK-DGS 2050
Query: 254 SIG--VEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
+ G+QVL L ++ + +G Y C A +R + V
Sbjct: 2051 PVSSFSNGLQVLS--GGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP----- 2103
Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGS 371
PN +G Q++S
Sbjct: 2104 PNIMGE--------------------------------------------EQNVSVLISQ 2119
Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENS 431
+ C + +P L WLK+G L + ++ N S L + V+D Y C A N
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNV 2179
Query: 432 TGSNQ 436
G +
Sbjct: 2180 AGKTE 2184
Score = 79.0 bits (193), Expect = 1e-14
Identities = 100/435 (22%), Positives = 157/435 (36%), Gaps = 90/435 (20%)
Query: 38 LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
L C+ PP I+W ++ + + V ++ DG + L +++ S +Y C A N
Sbjct: 3079 LECESNAVPPPVITWYKNGRMITESTHVEILADGQM----LHIKKAEVSDTGQYVCRAIN 3134
Query: 98 RYGRLVSRQARVQLASLSRFHQH---PESIEVERGGV--------ARFQCLIQGVPEPSI 146
GR FH + P SIE V C G+P P+I
Sbjct: 3135 VAGR-----------DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTI 3183
Query: 147 SWEHNGTAL-NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
+W N + N+ + V +L G L I +D G Y C+A N+ LS
Sbjct: 3184 AWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKY---YFLS 3240
Query: 205 VGPLRLLQEPEILSG---PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ 261
+ Q P ++G P ++++ + + L C A P PL+ W + DG+ I +
Sbjct: 3241 I------QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLK-DGKPIASGETE 3293
Query: 262 VLDILDTGN-LMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
+ + G+ L I +G Y C A N G R V +
Sbjct: 3294 RIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTP------------- 3340
Query: 320 EHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVA 379
RG++ ++L +S+ + C A
Sbjct: 3341 ----------TIRGNKDEAEKLMTLVDTSINIE------------------------CRA 3366
Query: 380 QGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASA 439
G P ++ WLKNG L ++IRL + + V D A+Y CVA N G +
Sbjct: 3367 TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHY 3426
Query: 440 RLVVTGGPEPPRPQG 454
L V P G
Sbjct: 3427 NLQVFAPPNMDNSMG 3441
Score = 73.6 bits (179), Expect = 6e-13
Identities = 96/436 (22%), Positives = 162/436 (37%), Gaps = 71/436 (16%)
Query: 25 LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
L D + + L C+V G P I+W +D L + ++ G L
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRF----LQITNVQ 2541
Query: 85 PSRAHEYHCVAQNRYG---RLVSRQARVQ--LASLSRFHQHPESIEVERGGVARFQCLIQ 139
Y C+A + G R S V +A + +PE + V C
Sbjct: 2542 VPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGS-DGNPEDVTVILNSPTSLVCEAY 2600
Query: 140 GVPEPSISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
P +I+W +GT L +N + +LP G L I + + + G Y CVA N A +
Sbjct: 2601 SYPPATITWFKDGTPLE-SNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKH 2658
Query: 199 AQLTLSVGPLRLLQEPEILS---GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
++ + + P ++ + ++ P+ + + V+ T LEC A + P +SW + DG+ +
Sbjct: 2659 YEVKVYIPP--IINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYK-DGQPL 2715
Query: 256 GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
+ ++I G+ L I + + +G Y C A+ + GE +
Sbjct: 2716 --KSDDHVNIAANGHTLQIKEAQISDTGRYTCVASN--------------IAGEDELDFD 2759
Query: 315 VGRVLEHPSSLTGAW-----IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPP 369
V ++ P S W + G K + + P S+
Sbjct: 2760 VN--IQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLY------------------- 2798
Query: 370 GSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAE 429
C P L W K+G L+ + + + L + VED Y CVA
Sbjct: 2799 -------CETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAV 2851
Query: 430 NSTG--SNQASARLVV 443
N G S Q R++V
Sbjct: 2852 NEAGEDSLQYDVRVLV 2867
Score = 73.2 bits (178), Expect = 7e-13
Identities = 77/296 (26%), Positives = 115/296 (38%), Gaps = 21/296 (7%)
Query: 21 FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
F + GD L L C+ G P ++W N + + D + L
Sbjct: 4262 FTELPGDVSLNKGEQLRLSCKATGIPLPKLTWT------FNNNIIPAHFDSVNGHSELVI 4315
Query: 81 RRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFH-QHPESIEVERGGVARFQCLIQ 139
R + Y C A+N G V V + F +P + GG A C ++
Sbjct: 4316 ERVSKEDSGTYVCTAENSVG-FVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVK 4374
Query: 140 GVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
G P P+I W G + + HR+ L +G L I D G Y CVA N A +
Sbjct: 4375 GDPTPTIQWNRKGVDIEIS-HRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVE-RSM 4432
Query: 200 QLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEG 259
LTL P+ L+ P + +L C AT P P ++WSR G SI +
Sbjct: 4433 SLTLQSPPIITLE-------PVETVINAGGKIILNCQATGEPQPTITWSR-QGHSISWD- 4483
Query: 260 IQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGPNW 314
+++L +L I+D + + + C A N G+ + R V + G Q W
Sbjct: 4484 -DRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAW 4538
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 23/194 (11%)
Query: 13 CAAGSELAFVQELG------------DTVAVWEHPL----VLPCQVEGEPPVSISWQRDR 56
C A + + FV+ +G D + W PL +L C+V+G+P +I W R
Sbjct: 4328 CTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKG 4387
Query: 57 LALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSR 116
+ + + + +GSL + ++ A +Y CVA N G +V R + L S
Sbjct: 4388 VDIEISHRIRQLGNGSLAIYG-----TVNEDAGDYTCVATNEAG-VVERSMSLTLQSPPI 4441
Query: 117 FHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVS 176
P + GG C G P+P+I+W G +++ + RV +L + L+I
Sbjct: 4442 ITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISW-DDRVNVLSNNSLYIADAQ 4500
Query: 177 QTDMGTYRCVAWNV 190
+ D + CVA N+
Sbjct: 4501 KEDTSEFECVARNL 4514
Score = 69.7 bits (169), Expect = 8e-12
Identities = 77/355 (21%), Positives = 131/355 (36%), Gaps = 63/355 (17%)
Query: 136 CLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRH 195
C + + ++S+ NG L + + S L I V+ +D G Y C+A + A T
Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQY-LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGR 509
Query: 196 SQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
+Q + + P ++ P N+T+T + AVL C+ S ++W R D R +
Sbjct: 510 AQTF--------FDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRND-RDV 560
Query: 256 GVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWV 315
+ + L +L + V +G Y C + G
Sbjct: 561 RLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG----------------------- 597
Query: 316 GRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIF 375
G +A S L + P+ P++ S GS
Sbjct: 598 --------------------------GSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSI 631
Query: 376 TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
C A G P+ ++ W N + + R+T ++ TL + + +D IY C+A NS G++
Sbjct: 632 MCSATGYPKPKIAWTVNDMFIVGSHRYRMT-SDGTLFIKNAAPKDAGIYGCLASNSAGTD 690
Query: 436 QASARLVVTGGPEPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRP 488
+ ++ L P+ Q G + G PP + G L LRP
Sbjct: 691 KQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKG-DLELRP 744
Score = 67.8 bits (164), Expect = 3e-11
Identities = 93/421 (22%), Positives = 149/421 (35%), Gaps = 64/421 (15%)
Query: 31 VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
V +P+ L C+ G P S++W +D +++ S + G LA ++ S R
Sbjct: 2024 VVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGR--- 2080
Query: 91 YHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEH 150
Y CVA N G R +++ +++ V C +P P+++W
Sbjct: 2081 YTCVAVNAAGEK-QRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLK 2139
Query: 151 NGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
+G L +L I D G Y C A NVA + ++ + + V
Sbjct: 2140 DGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG-KTEKNYNVNIWV----- 2193
Query: 211 LQEPEILSGPQNLT-LTVHQTAVLE--CIATSHPWPLVSWSRLDGRSIGVEGIQVLDILD 267
P + G LT LTV + ++ C ++ P P + W + G + + + + IL
Sbjct: 2194 ---PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKK-KGSPVLTDSMGRVRILS 2249
Query: 268 TGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
G L IS + +Y C A ++V TA+ +Q V P+
Sbjct: 2250 GGRQLQISIAEKSDAALYSCVA----SNVAGTAKKEYNLQ-----------VYIRPTITN 2294
Query: 327 GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
GS P + G S C QG+P
Sbjct: 2295 S-----GSH--------------------------PTEIIVTRGKSISLECEVQGIPPPT 2323
Query: 387 LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
+ W+K+G L + + L L + V D Y CVA N G L V
Sbjct: 2324 VTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAP 2383
Query: 447 P 447
P
Sbjct: 2384 P 2384
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 118 bits (296), Expect = 1e-26
Identities = 95/375 (25%), Positives = 156/375 (41%), Gaps = 67/375 (17%)
Query: 121 PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANH-RVTLLPSGILHITSVSQTD 179
P+ +EV G F C +G P+P I W HN +L+ + R+ + G L I + ++D
Sbjct: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299
Query: 180 MGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATS 239
G Y+C+A N A +Q A L S P + P + PQ+ + + + LEC+AT
Sbjct: 300 QGVYQCMARNSAGEAKTQSAMLRYSSLPAK----PSFVIQPQDTEVLIGTSTTLECMATG 355
Query: 240 HPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTA 299
HP PL++W+R +G + ++G + + + L + +++ + G + C AN +H A
Sbjct: 356 HPHPLITWTRDNG--LELDGSR--HVATSSGLYLQNITQRDHGRFTCHAN--NSHGTVQA 409
Query: 300 QGVLLVQGEPQ--------------GPNWVGRVLEHPSSLTGAWIWRGSRAGGK------ 339
++VQ PQ W+ +P + +W ++ GG+
Sbjct: 410 AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVI---VW--TKTGGQLPVEGQ 464
Query: 340 ----------------------------RLGLTAPSSMLL--PAQLPEFVQWPQSLSKPP 369
LG+ S L P L F Q PQ S
Sbjct: 465 HTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEV 524
Query: 370 GSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAE 429
G + +C AQG P+ + W K G ++ + + TL + D+ Y+CVA
Sbjct: 525 GKNINISCHAQGEPQPIITWNKEGVQITESGKFHV-DDEGTLTIYDAGFPDQGRYECVAR 583
Query: 430 NSTGSNQASARLVVT 444
NS G + L VT
Sbjct: 584 NSFGLAVTNMFLTVT 598
Score = 86.3 bits (212), Expect = 8e-17
Identities = 83/305 (27%), Positives = 126/305 (41%), Gaps = 34/305 (11%)
Query: 20 AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
+FV + DT + L C G P I+W RD +G+ L DGS H+A
Sbjct: 331 SFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRD-------NGLEL--DGSRHVATSS 381
Query: 80 SR--RSLPSRAH-EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQC 136
+++ R H + C A N +G V A + + + +F P+ V + C
Sbjct: 382 GLYLQNITQRDHGRFTCHANNSHGT-VQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLC 440
Query: 137 LIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHS 196
G P P I W G L T+L SG L I +Q D G Y C A S+
Sbjct: 441 EADGNPPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQA---VSSLGV 496
Query: 197 QDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIG 256
+ + L+V P L ++ PQ+ ++ V + + C A P P+++W++
Sbjct: 497 KKVSVQLTVKPKALAVFTQL---PQDTSVEVGKNINISCHAQGEPQPIITWNK------- 546
Query: 257 VEGIQVLD-----ILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQ 310
EG+Q+ + + D G L I D G Y C A N G V V +QG
Sbjct: 547 -EGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQA 605
Query: 311 GPNWV 315
G ++V
Sbjct: 606 GDDFV 610
Score = 65.5 bits (158), Expect = 2e-10
Identities = 60/237 (25%), Positives = 91/237 (38%), Gaps = 48/237 (20%)
Query: 212 QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
Q P I PQ++ + T C A +P P + W + S+ +E L++ D G L
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIH-NNHSLDLEDDTRLNVFDDGTL 290
Query: 272 MISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIW 331
MI + GVY C A R + G Q +L + S
Sbjct: 291 MIRNTRESDQGVYQCMA--------RNSAGEAKTQSA---------MLRYSS-------- 325
Query: 332 RGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK 391
LPA+ P FV PQ G+S C+A G P + W +
Sbjct: 326 -------------------LPAK-PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTR 365
Query: 392 NGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
+ + G+ R +S L L ++ D + C A NS G+ QA+A ++V P+
Sbjct: 366 DNGLELDGS--RHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ 420
Score = 61.2 bits (147), Expect = 3e-09
Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 2/99 (2%)
Query: 354 QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRL-THNNSTLM 412
Q P PQ + P G++ FTC A+G P+ ++W+ N L ++ RL ++ TLM
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291
Query: 413 LAGVSVEDEAIYQCVAENSTG-SNQASARLVVTGGPEPP 450
+ D+ +YQC+A NS G + SA L + P P
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKP 330
>gi|15147240 brother of CDO [Homo sapiens]
Length = 1114
Score = 117 bits (293), Expect = 3e-26
Identities = 149/618 (24%), Positives = 232/618 (37%), Gaps = 151/618 (24%)
Query: 3 LLLLLLPGWGCAAG---------SELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQ 53
L LLL GC A + VQ+ G TV +L C VE P ++++W+
Sbjct: 18 LACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTV-------ILGCVVE-PPRMNVTWR 69
Query: 54 RDRLAL--ANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQL 111
+ L ++++ L+ G+L + AL + Y CVA+ G + S A V L
Sbjct: 70 LNGKELNGSDDALGVLITHGTLVITALNNHT-----VGRYQCVARMPAGAVASVPATVTL 124
Query: 112 ASLSRFHQHPES-IEVERGGVARFQC-LIQGVPEPSISWEHNGTALNTANHRVTLLPSGI 169
A+L F + IEV+ G A C L + P+ + + L + ++PSG
Sbjct: 125 ANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN 184
Query: 170 LHITSVSQTDMGTYRCVAWN-----VASTRHSQDAQLTLSVG-PLRLLQEPEILSGPQNL 223
L I + SQ D G Y+C A+N V ++ S ++ S R++ PE Q +
Sbjct: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE----AQTI 240
Query: 224 TLTVHQTAVLECIATSHPWPLVSWSRLDGRSI-GVEGIQVLDILDTGNLMISDVSVQHSG 282
+T Q+ +LEC+A+ P P V+W++ DG S+ G + L NL+I S + SG
Sbjct: 241 IVTKGQSLILECVASGIPPPRVTWAK-DGSSVTGYNKTRFL----LSNLLIDTTSEEDSG 295
Query: 283 VYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLG 342
Y C A+ V + V+L + P
Sbjct: 296 TYRCMAD---NGVGQPGAAVILYNVQVFEP------------------------------ 322
Query: 343 LTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNI 402
PE L P G SA TC +G P ++WL+N L +
Sbjct: 323 -------------PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRL 369
Query: 403 RLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARL----------------VVTGG 446
RL+ L + + EDE +YQC+AEN GS A +L + TG
Sbjct: 370 RLSRR--ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGT 427
Query: 447 PE---------------------------PPRPQGPACHGSLYFCHSSVLGATPPSSR-- 477
P P PQ P G + ++ ++P +S+
Sbjct: 428 PPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTD 487
Query: 478 ----------------DIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTI 521
I+ YV+ R V S I + L+P + Y +
Sbjct: 488 SYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEV 547
Query: 522 HLRAYSAEGASQDSAPIF 539
+ AY+ G Q + F
Sbjct: 548 EMAAYNCAGEGQTAMVTF 565
Score = 38.9 bits (89), Expect = 0.015
Identities = 30/101 (29%), Positives = 41/101 (40%), Gaps = 19/101 (18%)
Query: 569 EPAALYDIKLQAFNGNGDGNSSARCVSLCDVP---------------LATPDGTV--STE 611
+P YDIK+Q FN G+ S V +C+ LA P + + E
Sbjct: 781 QPETSYDIKMQCFNEGGESEFSN--VMICETKARKSSGQPGRLPPPTLAPPQPPLPETIE 838
Query: 612 SKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWR 652
G SS LP ++VG+ +G LII F WR
Sbjct: 839 RPVGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWR 879
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 111 bits (277), Expect = 2e-24
Identities = 113/429 (26%), Positives = 178/429 (41%), Gaps = 77/429 (17%)
Query: 33 EHPLVLPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAH 89
E + L C+V+G P I W+ + + ++G+ + +GSL L + + A
Sbjct: 43 EKKVKLNCEVKGNPKPHIRWKLNGTDV--DTGMDFRYSVVEGSL----LINNPNKTQDAG 96
Query: 90 EYHCVAQNRYGRLVSRQARVQLASLSRFHQHPES-IEVERGGVARFQCLIQGVP----EP 144
Y C A N +G +VSR+A++Q A L F S + V RG + L+ G P E
Sbjct: 97 TYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRG---QGMVLLCGPPPHSGEL 153
Query: 145 SISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRH---SQDAQL 201
S +W N N R +G L+I V ++D+G Y CV N T H L
Sbjct: 154 SYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTV-TNHKVLGPPTPL 212
Query: 202 TLSVGPLRLLQEPEI-LSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
L + EP+I + P+ + T LEC A +P P + W R DG+ I +
Sbjct: 213 ILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKAR 272
Query: 261 QVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLE 320
+ G L I + + +G+Y C A + + A+G L + PNW+ ++ +
Sbjct: 273 R---HKSNGILEIPNFQQEDAGLYECVAE--NSRGKNVARGQLTFYAQ---PNWIQKIND 324
Query: 321 HPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQ 380
+ + E V W C A
Sbjct: 325 ------------------------------IHVAMEENVFW--------------ECKAN 340
Query: 381 GVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASAR 440
G P+ WLKNG+ L + I++ TL + V++ D +YQC+AEN G ++A
Sbjct: 341 GRPKPTYKWLKNGEPLLTRDRIQI--EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAE 398
Query: 441 L-VVTGGPE 448
L V+ GP+
Sbjct: 399 LSVIAVGPD 407
Score = 89.7 bits (221), Expect = 7e-18
Identities = 129/545 (23%), Positives = 218/545 (40%), Gaps = 67/545 (12%)
Query: 21 FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
++Q++ D E + C+ G P + W ++ L + + G+L++ +
Sbjct: 318 WIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI-EQGTLNITIVNL 376
Query: 81 RRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH--PESIEVERGGVARFQCLI 138
S A Y C+A+N++G + S +A F + V+ GG +C
Sbjct: 377 -----SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431
Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
+ P+P +W+ G + N R+T+ G L I +V+++D G+Y C+A N T
Sbjct: 432 KASPKPVYTWK-KGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT----- 485
Query: 199 AQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIAT-SHPWPLV-SWS----RLDG 252
S G L + ++ P ++ +TV ++ VL C T H +V +WS +D
Sbjct: 486 ---ASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDF 542
Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHV-RRTAQGVLLVQGEPQG 311
G +V G+LMI ++ ++H+G YVC T V R +A L+V+G P
Sbjct: 543 DRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQ---TSVDRLSAAADLIVRGPPGP 599
Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPG- 370
P V ++ + T WR + + ++ A+ P V W Q++S P
Sbjct: 600 PEAV--TIDEITDTTAQLSWRPGPDNHSPI-----TMYVIQARTPFSVGW-QAVSTVPEL 651
Query: 371 -SSAIFTCVAQGVP-----ESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIY 424
FT G+ E R V V+ G R + T +EA+
Sbjct: 652 IDGKTFTATVVGLNPWVEYEFRTV---AANVIGIGEPSRPSEKRRT---------EEALP 699
Query: 425 QCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCH---SSVLGATPPSSRDIIG 481
+ N +G + + LV+T P Q G + + T +S D
Sbjct: 700 EVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASR 759
Query: 482 YVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSA-EGASQDSAPIFA 540
YV V S E++ + E FS P T YSA E ++ A IFA
Sbjct: 760 YVFRNESVHPFSPFEVKVGVFNNKGEGPFS---PTTV------VYSAEEEPTKPPASIFA 810
Query: 541 STMGS 545
++ +
Sbjct: 811 RSLSA 815
Score = 36.6 bits (83), Expect = 0.075
Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 356 PEFVQWPQSLSKPPGSS---AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLM 412
P F+Q P + P S C +G P+ + W NG + G + R + +L+
Sbjct: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLL 85
Query: 413 LAGVS-VEDEAIYQCVAENSTGS 434
+ + +D YQC A NS G+
Sbjct: 86 INNPNKTQDAGTYQCTATNSFGT 108
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 110 bits (274), Expect = 5e-24
Identities = 120/464 (25%), Positives = 175/464 (37%), Gaps = 81/464 (17%)
Query: 40 CQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRY 99
C G P ISW R+ AL +S + + G+L + + P A Y C A N
Sbjct: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVA-----PEDAGNYSCQATNEV 566
Query: 100 GRLVSRQARVQLASLSRFHQHPESIE-------VERGGVARFQCLIQGVPEPSISWEHNG 152
G +++ ++ P S+ V G A C GVP P + W G
Sbjct: 567 G--------TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 618
Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
+ A + SG L I + + D GTY C A N A++ L+VG
Sbjct: 619 LEMILAPEGSS---SGKLRIPAAQERDAGTYTCRAVNELG---DASAEIQLAVG-----H 667
Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV-----EGIQVLDILD 267
P++ P+++T+ + ++A+L C AT P P V+W R DG+ +G+ G + D
Sbjct: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ-PD 726
Query: 268 TGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG--RVLE-HPSS 324
+G L V+ + YVC A V+ A+ ++ PQ + RVLE P S
Sbjct: 727 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 786
Query: 325 L-----------TGAWIWRG-SRAGGKRLGLTAPSSMLLPAQLPE--------------- 357
L W+ G G R + A S+ L L E
Sbjct: 787 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 846
Query: 358 -------FVQWPQSLSKP-------PGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIR 403
VQ P + G A CVA GVP + W K L+
Sbjct: 847 QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 906
Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
TL++A S +D Y C A N+ G + RL V P
Sbjct: 907 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950
Score = 103 bits (257), Expect = 5e-22
Identities = 93/304 (30%), Positives = 130/304 (42%), Gaps = 17/304 (5%)
Query: 28 TVAVWE-HPLVLPCQV-EGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP 85
TV V E P+ LPC V G P W +D L S ++ DGSLHL R+L
Sbjct: 776 TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-----RALQ 830
Query: 86 SRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQHPESIE--VERGGVARFQCLIQGVPE 143
A Y CVA N G S+ V+L HP + G A C+ GVP
Sbjct: 831 EHAGRYSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887
Query: 144 PSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTL 203
P+I+W AL + + G L I S D G Y C A N SQ+ +L++
Sbjct: 888 PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF-SSQEMRLSV 946
Query: 204 SVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVL 263
+ P + + P +T + L+C A P PLV+W++ D R +
Sbjct: 947 NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTK-DSRPV-PPITNRY 1004
Query: 264 DILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPS 323
+L +G+L ++ V V SG Y C A+ P + + VL VQG V HP+
Sbjct: 1005 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSA--SHRYVLGVQGRTSWQPQSLPVPHHPA 1062
Query: 324 SLTG 327
L+G
Sbjct: 1063 CLSG 1066
Score = 94.0 bits (232), Expect = 4e-19
Identities = 118/475 (24%), Positives = 180/475 (37%), Gaps = 106/475 (22%)
Query: 37 VLPCQVEGEPPVSISWQRD-------RLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
+L C+ G PP +++W+R RL S G L ++ P
Sbjct: 687 LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP---- 742
Query: 90 EYHCVAQNRYGR-------LVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLI-QGV 141
Y C A+N +G+ +V+ A Q+AS + ++ V G C++ G
Sbjct: 743 -YVCEARNVFGKVQAEARLIVTGHAPPQIASSA------PTVRVLEGQPVSLPCIVLAGR 795
Query: 142 PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
P P W +G L + R ++ G LH+ Q G Y CVA N A ++H +D +L
Sbjct: 796 PLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH-RDVEL 853
Query: 202 TLSVGPLRLLQEPEILSGPQNLTLTVHQT-----AVLECIATSHPWPLVSWSRLDGRSIG 256
+ V P R+ + T T H T A L C+A+ P P ++W++ + ++
Sbjct: 854 VVQVPP-RI-----------HPTATHHITNEGVPASLPCVASGVPAPTITWTK-ETNALT 900
Query: 257 VEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG 316
G ++ G L+I+ S Q +G YVC A T + + L V +P+
Sbjct: 901 SRGPH-YNVSKEGTLLIAQPSAQDAGAYVCTAT--NTVGFSSQEMRLSVNTKPR------ 951
Query: 317 RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFT 376
GSR L +TA + G
Sbjct: 952 ------------IHMNGSRNANVPLQVTAKA----------------------GEEVTLD 977
Query: 377 CVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
C A+G P + W K+ + + P N + +L LA V V D Y+C A N GS
Sbjct: 978 CEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
Query: 437 ASARLVVTGGP--EP---PRPQGPACHG------------SLYFCHSSVLGATPP 474
L V G +P P P PAC S+ CH S+ PP
Sbjct: 1038 HRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLCHLSLRAPLPP 1092
Score = 90.1 bits (222), Expect = 6e-18
Identities = 109/465 (23%), Positives = 172/465 (36%), Gaps = 72/465 (15%)
Query: 35 PLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
PL++ C V P + +R L E + S + R+ + Y C
Sbjct: 326 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEIL-----RASKAEEGTYECT 380
Query: 95 AQNRYGRLVSRQARVQLASLSRFHQ--HPESIEVERGGVARFQCLIQGVPEPSISWEHNG 152
A +R G + +A+ Q+ Q ++ V G A C + G +++W +
Sbjct: 381 AVSRAG---TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW 437
Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
L + RV L L I+ + TD G Y+CVA N +T + L + +
Sbjct: 438 RVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG--------VTRASVWLLVRE 489
Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM 272
P++ + + + C A+ +P P +SWSR S ++ + + G L+
Sbjct: 490 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR---ESQALQEDSRIHVDAQGTLI 546
Query: 273 ISDVSVQHSGVYVC-AANRPGTH----------------------VRRTAQGVLLVQGEP 309
I V+ + +G Y C A N GT V + VL+ +
Sbjct: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASG 606
Query: 310 QGPNWVGRVLEHPSSLTGAWIWRGSRAGGKR-------------------LGLTAPSSML 350
P RV+ + L GS +G R LG + L
Sbjct: 607 VPP---PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663
Query: 351 LPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKN-----GKVLSPGNNIRLT 405
P+ + P+ ++ G SA+ C A G P + W + G L G R
Sbjct: 664 AVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR 723
Query: 406 HNNS-TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
+S L V+ ED+A Y C A N G QA ARL+VTG P
Sbjct: 724 QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768
Score = 34.7 bits (78), Expect = 0.28
Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 408 NSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP--PRPQGPACHGSLYFCH 465
NS+ + S +E Y+C A + G+ +A A++VVT P P P G
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
Query: 466 SSVLGATP 473
VLG P
Sbjct: 421 CRVLGEAP 428
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 107 bits (267), Expect = 3e-23
Identities = 148/604 (24%), Positives = 221/604 (36%), Gaps = 105/604 (17%)
Query: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
MGLL++LL G GCAA F++E D + V CQ G+P ++W + +
Sbjct: 16 MGLLVVLLVG-GCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN 74
Query: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQL------ASL 114
++ T+ D S P + Y CVAQN G + L +
Sbjct: 75 SQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGF 134
Query: 115 SRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALN--TANHRVTLLPSGILHI 172
P+ VER A C G P+P I+W + ++ +N R+ L SG L I
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQI 194
Query: 173 TSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAV 232
S +TD G Y CVA N A R+S A L + V + P P + +
Sbjct: 195 ESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVA----PRFSILPMSHEIMPGGNVN 250
Query: 233 LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA---- 288
+ C+A P P V W + G E + D + G ++ V+ S Y C A
Sbjct: 251 ITCVAVGSPMPYVKWMQ------GAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSL 304
Query: 289 ---------------NRPGTHV--RRTAQGVLLV--QGEPQGPNWVGRVLEHPS-SLTGA 328
PGT + TA + + G P ++ V+E+ S S G
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYY--VIEYKSKSQDGP 362
Query: 329 W-IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR- 386
+ I +G +P+S + +V S+ + P S ++ T + P S
Sbjct: 363 YQIKEDITTTRYSIGGLSPNS-----EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417
Query: 387 --------------LVWLK----NGKV--------LSP----GNNIRLTHNNSTLMLAGV 416
+ W + NG + + P GN + ++S L G
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477
Query: 417 SVEDEAI-YQCVAENSTGSNQASARLVVT---GGPEPPRPQGPACHGSLYFCHSSVLGAT 472
+EDE + +A S G S + V G P P S L +
Sbjct: 478 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET----SITLSWS 533
Query: 473 PPSSRDIIGYVL------HLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAY 526
PP II Y L H R VG P T+ +V +L+P T Y L A
Sbjct: 534 PPRQESIIKYELLFREGDHGREVGRTFDP---------TTSYVVEDLKPNTEYAFRLAAR 584
Query: 527 SAEG 530
S +G
Sbjct: 585 SPQG 588
Score = 78.6 bits (192), Expect = 2e-14
Identities = 103/440 (23%), Positives = 163/440 (37%), Gaps = 78/440 (17%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSG---ILHI 172
RF + P+ GGVA F C G P+P ++W G +N+ +L I
Sbjct: 34 RFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRI 93
Query: 173 TSV-SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA 231
+ + D Y CVA N + A+LT+ P I GPQ + +TA
Sbjct: 94 QPLRTPRDENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 232 VLECIATSHPWPLVSW---------SRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSG 282
+ C A+ +P P ++W S +GR + L +G L I G
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGR---------IKQLRSGALQIESSEETDQG 203
Query: 283 VYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLG 342
Y C A VR ++ L V+ V RV
Sbjct: 204 KYECVATN-SAGVRYSSPANLYVR--------VRRVA----------------------- 231
Query: 343 LTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNI 402
P F P S PG + TCVA G P + W++ + L+P +++
Sbjct: 232 -------------PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDM 278
Query: 403 RLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLY 462
+ N +L V+D A Y CVA +S G +A A++ V P+ P + +
Sbjct: 279 PVGRN----VLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATS 334
Query: 463 FCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIH 522
+ G P S YV+ + + +++E I+ T+ + L P + Y I
Sbjct: 335 ITITWDSGNPDPVSY----YVIEYKSKSQDGPYQIKEDIT--TTRYSIGGLSPNSEYEIW 388
Query: 523 LRAYSAEGASQDSAPIFAST 542
+ A ++ G S + T
Sbjct: 389 VSAVNSIGQGPPSESVVTRT 408
Score = 42.4 bits (98), Expect = 0.001
Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 7/129 (5%)
Query: 427 VAENSTGSNQASARLVV-TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRD---IIGY 482
VA G S+ +VV T P P +L VL +P R I GY
Sbjct: 684 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 743
Query: 483 VLH-LRPVG-EPSGP-ELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIF 539
+H +R G E GP +++ + E V +NL+P TAY+I + AY+ +G S P
Sbjct: 744 QVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 803
Query: 540 ASTMGSNLG 548
T G+ LG
Sbjct: 804 VVTKGAVLG 812
Score = 33.5 bits (75), Expect = 0.63
Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 473 PPSSRD--IIGYVLHLRPVG-EPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAE 529
PP + + ++GY + RP+G E P+ I T++ + LE T Y I A++
Sbjct: 630 PPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEV 689
Query: 530 GASQDSAPIFAST 542
G +S+P+ T
Sbjct: 690 GPGPESSPVVVRT 702
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 107 bits (267), Expect = 3e-23
Identities = 148/604 (24%), Positives = 221/604 (36%), Gaps = 105/604 (17%)
Query: 1 MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
MGLL++LL G GCAA F++E D + V CQ G+P ++W + +
Sbjct: 16 MGLLVVLLVG-GCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN 74
Query: 61 NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQL------ASL 114
++ T+ D S P + Y CVAQN G + L +
Sbjct: 75 SQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGF 134
Query: 115 SRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALN--TANHRVTLLPSGILHI 172
P+ VER A C G P+P I+W + ++ +N R+ L SG L I
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQI 194
Query: 173 TSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAV 232
S +TD G Y CVA N A R+S A L + V + P P + +
Sbjct: 195 ESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVA----PRFSILPMSHEIMPGGNVN 250
Query: 233 LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA---- 288
+ C+A P P V W + G E + D + G ++ V+ S Y C A
Sbjct: 251 ITCVAVGSPMPYVKWMQ------GAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSL 304
Query: 289 ---------------NRPGTHV--RRTAQGVLLV--QGEPQGPNWVGRVLEHPS-SLTGA 328
PGT + TA + + G P ++ V+E+ S S G
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYY--VIEYKSKSQDGP 362
Query: 329 W-IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR- 386
+ I +G +P+S + +V S+ + P S ++ T + P S
Sbjct: 363 YQIKEDITTTRYSIGGLSPNS-----EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417
Query: 387 --------------LVWLK----NGKV--------LSP----GNNIRLTHNNSTLMLAGV 416
+ W + NG + + P GN + ++S L G
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477
Query: 417 SVEDEAI-YQCVAENSTGSNQASARLVVT---GGPEPPRPQGPACHGSLYFCHSSVLGAT 472
+EDE + +A S G S + V G P P S L +
Sbjct: 478 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET----SITLSWS 533
Query: 473 PPSSRDIIGYVL------HLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAY 526
PP II Y L H R VG P T+ +V +L+P T Y L A
Sbjct: 534 PPRQESIIKYELLFREGDHGREVGRTFDP---------TTSYVVEDLKPNTEYAFRLAAR 584
Query: 527 SAEG 530
S +G
Sbjct: 585 SPQG 588
Score = 78.6 bits (192), Expect = 2e-14
Identities = 103/440 (23%), Positives = 163/440 (37%), Gaps = 78/440 (17%)
Query: 116 RFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSG---ILHI 172
RF + P+ GGVA F C G P+P ++W G +N+ +L I
Sbjct: 34 RFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRI 93
Query: 173 TSV-SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA 231
+ + D Y CVA N + A+LT+ P I GPQ + +TA
Sbjct: 94 QPLRTPRDENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152
Query: 232 VLECIATSHPWPLVSW---------SRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSG 282
+ C A+ +P P ++W S +GR + L +G L I G
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGR---------IKQLRSGALQIESSEETDQG 203
Query: 283 VYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLG 342
Y C A VR ++ L V+ V RV
Sbjct: 204 KYECVATN-SAGVRYSSPANLYVR--------VRRVA----------------------- 231
Query: 343 LTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNI 402
P F P S PG + TCVA G P + W++ + L+P +++
Sbjct: 232 -------------PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDM 278
Query: 403 RLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLY 462
+ N +L V+D A Y CVA +S G +A A++ V P+ P + +
Sbjct: 279 PVGRN----VLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATS 334
Query: 463 FCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIH 522
+ G P S YV+ + + +++E I+ T+ + L P + Y I
Sbjct: 335 ITITWDSGNPDPVSY----YVIEYKSKSQDGPYQIKEDIT--TTRYSIGGLSPNSEYEIW 388
Query: 523 LRAYSAEGASQDSAPIFAST 542
+ A ++ G S + T
Sbjct: 389 VSAVNSIGQGPPSESVVTRT 408
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 107 bits (267), Expect = 3e-23
Identities = 118/437 (27%), Positives = 177/437 (40%), Gaps = 76/437 (17%)
Query: 21 FVQELGDTVAVW---EHPLVLPCQVEGEPPVSISWQRDRLALANESGVTL-MPDGSLHLA 76
FVQE D + E + L C+V G P S W R+ + ES + DG+ +
Sbjct: 101 FVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFII- 159
Query: 77 ALPSRRSLPSRAHE---YHCVAQNRYGRLVSRQARVQLASLSRFHQHPES-IEVERG-GV 131
S PS A + Y C+A N G ++SR+A +Q A L F S + V G GV
Sbjct: 160 ------SNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGV 213
Query: 132 ARFQCLIQGVPEPSISWEHNGTALNTA--NHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
PE SW N A + R +G L+I+ V +D+G+Y C+ N
Sbjct: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
Query: 190 VASTRH--SQDAQLTLSVGPLRLLQEPEI-LSGPQNLTLTVHQTAVLECIATSHPWPLVS 246
+ S LTL + EP+I + P +T T +EC A +P P ++
Sbjct: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
Query: 247 WSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ 306
W +++G ++ + L I +V + +G+Y C A + + + +G L V
Sbjct: 334 WMKVNGYIPSKARLRKSQAV----LEIPNVQLDDAGIYECRAE--NSRGKNSFRGQLQVY 387
Query: 307 GEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLS 366
P+WV ++L T S
Sbjct: 388 ---TYPHWV-----------------------EKLNDTQLDS------------------ 403
Query: 367 KPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQC 426
GS + C A G P WLKNG LSP + + + N LM+ V+ D +YQC
Sbjct: 404 ---GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV--NGVLMIHNVNQSDAGMYQC 458
Query: 427 VAENSTGSNQASARLVV 443
+AEN G+ ASA L +
Sbjct: 459 LAENKYGAIYASAELKI 475
Score = 94.7 bits (234), Expect = 2e-19
Identities = 130/556 (23%), Positives = 220/556 (39%), Gaps = 80/556 (14%)
Query: 21 FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
+V++L DT PL C+ G+P + W ++ + L+ +S V ++ +G L + +
Sbjct: 392 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV-NGVLMIHNVNQ 450
Query: 81 RRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRF--HQHPESIEVERGGVARFQCLI 138
S A Y C+A+N+YG + + LAS F +Q ++I V + +C
Sbjct: 451 -----SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP 505
Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
QG P+P+ISW+ A+ N R+ +LP G L I + S++D G Y C NV +
Sbjct: 506 QGSPKPTISWKKGDRAVRE-NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAE--- 561
Query: 199 AQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIA-------TSHPWPLVSWSRLD 251
+ L + + I P+ LTV ++ VL C A + W L +D
Sbjct: 562 -----IIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTL-KGQPID 615
Query: 252 GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
G + + +LMI ++ + H+G Y C V A+ LLV+G P
Sbjct: 616 FEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE--LLVRGPPGP 673
Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGS 371
P V ++E + T W + + SS L A+ P + W
Sbjct: 674 PGIV--IVEEITESTATLSWSPAADNHSPI-----SSYNLQARSPFSLGWQ--------- 717
Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAEN- 430
+ VPE +T + + M ++ E ++ VA N
Sbjct: 718 ------TVKTVPEI------------------ITGDMESAMAVDLNPWVEYEFRVVATNP 753
Query: 431 -STGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSR----DIIGYVLH 485
TG +R++ T P+ G H V+ P S + GY++
Sbjct: 754 IGTGDPSTPSRMIRT-NEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA 812
Query: 486 LRPVGEPSGPELQEAISKGTSEHVF--SNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
RP G E + S S+ ++ ++ P T + + + Y+ +G S + +
Sbjct: 813 FRPNGTRGWKE-KMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIV---VI 868
Query: 544 GSNLGEALNLPVPLKA 559
S GE P +KA
Sbjct: 869 CSAEGEPSAAPTDVKA 884
Score = 78.2 bits (191), Expect = 2e-14
Identities = 64/255 (25%), Positives = 113/255 (44%), Gaps = 29/255 (11%)
Query: 38 LPCQVEGEPPVSISWQR------DRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
+ C G P +I+W + + L V +P+ L A + Y
Sbjct: 320 MECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGI------------Y 367
Query: 92 HCVAQNRYGRLVSRQARVQLASLSRFHQHPESIEVERGGVARFQCLIQGVPEPSISWEHN 151
C A+N G+ S + ++Q+ + + + +++ G R++C G P P+ W N
Sbjct: 368 ECRAENSRGKN-SFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN 426
Query: 152 GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
G L+ + RV ++ +G+L I +V+Q+D G Y+C+A N ++ L+ P L
Sbjct: 427 GVPLSPQS-RVEMV-NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL 484
Query: 212 QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
+ + + + +T Q V+EC P P +SW + D V + + IL G+L
Sbjct: 485 NQLK-----KTIIVTKDQEVVIECKPQGSPKPTISWKKGDR---AVRENKRIAILPDGSL 536
Query: 272 MISDVSVQHSGVYVC 286
I + S G YVC
Sbjct: 537 RILNASKSDEGKYVC 551
Score = 40.8 bits (94), Expect = 0.004
Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 4/83 (4%)
Query: 356 PEFVQWPQSLSKPPGSS---AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLM 412
P FVQ P + P S C +G P WL+NG + ++ R + + T +
Sbjct: 99 PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 158
Query: 413 LAGVS-VEDEAIYQCVAENSTGS 434
++ S +D YQC+A N+ GS
Sbjct: 159 ISNPSEAKDSGHYQCLATNTVGS 181
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,407,544
Number of Sequences: 37866
Number of extensions: 1517462
Number of successful extensions: 10244
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 268
Number of HSP's successfully gapped in prelim test: 168
Number of HSP's that attempted gapping in prelim test: 4570
Number of HSP's gapped (non-prelim): 3388
length of query: 654
length of database: 18,247,518
effective HSP length: 109
effective length of query: 545
effective length of database: 14,120,124
effective search space: 7695467580
effective search space used: 7695467580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.