Guide to the Human Genome
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Search of human proteins with 116174736

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116174736 sentrin/SUMO-specific protease 7 isoform 2 [Homo
sapiens]
         (985 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116174736 sentrin/SUMO-specific protease 7 isoform 2 [Homo sa...  1959   0.0  
gi|116174746 sentrin/SUMO-specific protease 7 isoform 1 [Homo sa...  1775   0.0  
gi|156105703 SUMO1/sentrin specific peptidase 6 isoform 2 [Homo ...   209   1e-53
gi|156105701 SUMO1/sentrin specific peptidase 6 isoform 1 [Homo ...   209   1e-53
gi|7657550 sentrin/SUMO-specific protease 1 [Homo sapiens]             67   8e-11
gi|54607091 SUMO1/sentrin/SMT3 specific protease 2 [Homo sapiens]      63   1e-09
gi|159032029 SUMO1/sentrin specific peptidase 5 [Homo sapiens]         59   3e-08
gi|21361499 SUMO1/sentrin/SMT3 specific protease 3 [Homo sapiens]      51   6e-06
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    50   1e-05
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    46   2e-04
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    46   2e-04
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    46   2e-04
gi|56676335 RAP1 interacting factor 1 [Homo sapiens]                   46   2e-04
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    44   7e-04
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]    44   0.001
gi|210032580 SET domain containing 1B [Homo sapiens]                   43   0.002
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       42   0.002
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    42   0.003
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    41   0.005
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     41   0.005
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     41   0.005
gi|109255234 centrosomal protein 290kDa [Homo sapiens]                 41   0.005
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    41   0.005
gi|87299628 biorientation of chromosomes in cell division 1-like...    41   0.006
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    40   0.008
gi|38044112 restin isoform b [Homo sapiens]                            40   0.011
gi|4506751 restin isoform a [Homo sapiens]                             40   0.011
gi|20070262 TNF receptor-associated factor 3 interacting protein...    40   0.011
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    40   0.011
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    40   0.011

>gi|116174736 sentrin/SUMO-specific protease 7 isoform 2 [Homo
           sapiens]
          Length = 985

 Score = 1959 bits (5074), Expect = 0.0
 Identities = 985/985 (100%), Positives = 985/985 (100%)

Query: 1   MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLP 60
           MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLP
Sbjct: 1   MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLP 60

Query: 61  LQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRN 120
           LQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRN
Sbjct: 61  LQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRN 120

Query: 121 DANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHN 180
           DANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHN
Sbjct: 121 DANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHN 180

Query: 181 KEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRR 240
           KEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRR
Sbjct: 181 KEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRR 240

Query: 241 LRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDF 300
           LRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDF
Sbjct: 241 LRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDF 300

Query: 301 TKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILR 360
           TKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILR
Sbjct: 301 TKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILR 360

Query: 361 GHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPL 420
           GHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPL
Sbjct: 361 GHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPL 420

Query: 421 ITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKK 480
           ITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKK
Sbjct: 421 ITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKK 480

Query: 481 YIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLE 540
           YIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLE
Sbjct: 481 YIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLE 540

Query: 541 HSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQ 600
           HSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQ
Sbjct: 541 HSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQ 600

Query: 601 NLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQSSGCYS 660
           NLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQSSGCYS
Sbjct: 601 NLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQSSGCYS 660

Query: 661 LSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYL 720
           LSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYL
Sbjct: 661 LSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYL 720

Query: 721 KYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINI 780
           KYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINI
Sbjct: 721 KYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINI 780

Query: 781 FNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRT 840
           FNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRT
Sbjct: 781 FNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRT 840

Query: 841 TSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKL 900
           TSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKL
Sbjct: 841 TSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKL 900

Query: 901 KTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHV 960
           KTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHV
Sbjct: 901 KTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHV 960

Query: 961 IKTKREDIRELILKLHLQQQKGSSS 985
           IKTKREDIRELILKLHLQQQKGSSS
Sbjct: 961 IKTKREDIRELILKLHLQQQKGSSS 985


>gi|116174746 sentrin/SUMO-specific protease 7 isoform 1 [Homo
            sapiens]
          Length = 1050

 Score = 1775 bits (4598), Expect = 0.0
 Identities = 924/1051 (87%), Positives = 942/1051 (89%), Gaps = 67/1051 (6%)

Query: 1    MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSER---- 56
            MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSER    
Sbjct: 1    MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLP 60

Query: 57   ---------------------------------------------WT-LPLQWERSLRNK 70
                                                         WT L  ++ ++L   
Sbjct: 61   LQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRN 120

Query: 71   VISLDHKNKKHIRGCPVTSKSS----------------PERQLKVMLTNVLWTDLGRKFR 114
              +L   NK      P TS  S                 ER  +V+LTNVL T+LGRK+ 
Sbjct: 121  DANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERIPRVILTNVLGTELGRKYI 180

Query: 115  KTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSA 174
            +T P  + +L D + +QS+ L S+S  SLE+ Q L P  +S  LSERGSQRSKTVDDNSA
Sbjct: 181  RTPPVTEGSLSDTDNLQSEQLSSSSDGSLESYQNLNP-HKSCYLSERGSQRSKTVDDNSA 239

Query: 175  KQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLIS 234
            KQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLIS
Sbjct: 240  KQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLIS 299

Query: 235  RKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTK 294
            RKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTK
Sbjct: 300  RKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTK 359

Query: 295  PTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTI 354
            PTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTI
Sbjct: 360  PTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTI 419

Query: 355  EKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESA 414
            EKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESA
Sbjct: 420  EKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESA 479

Query: 415  LLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGC 474
            LLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGC
Sbjct: 480  LLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGC 539

Query: 475  VTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQE 534
            VTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQE
Sbjct: 540  VTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQE 599

Query: 535  IQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQ 594
            IQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQ
Sbjct: 600  IQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQ 659

Query: 595  AFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQ 654
            AFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQ
Sbjct: 660  AFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQ 719

Query: 655  SSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDV 714
            SSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDV
Sbjct: 720  SSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDV 779

Query: 715  IIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTW 774
            IIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTW
Sbjct: 780  IIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTW 839

Query: 775  TRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTI 834
            TRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTI
Sbjct: 840  TRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTI 899

Query: 835  DNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEV 894
            DNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEV
Sbjct: 900  DNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEV 959

Query: 895  EWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEK 954
            EWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEK
Sbjct: 960  EWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEK 1019

Query: 955  WFPRHVIKTKREDIRELILKLHLQQQKGSSS 985
            WFPRHVIKTKREDIRELILKLHLQQQKGSSS
Sbjct: 1020 WFPRHVIKTKREDIRELILKLHLQQQKGSSS 1050


>gi|156105703 SUMO1/sentrin specific peptidase 6 isoform 2 [Homo
           sapiens]
          Length = 1105

 Score =  209 bits (532), Expect = 1e-53
 Identities = 207/731 (28%), Positives = 317/731 (43%), Gaps = 142/731 (19%)

Query: 262 KKQEDDSTISTEFE-KPSENYHQDPKLPEEITTKPTKSDFTKLSSLNS---QELTLSNAT 317
           K +E +S +  E + K  +  H     P    +  +K   T L  L     Q +TL+ +T
Sbjct: 182 KTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQAITLNEST 241

Query: 318 ---------------KSASAGSTTETVENSNSIDIVGISSLVEKDENE---LNTIEKPIL 359
                          KS + G TT+    +N ++ V I  +V  D+++   L T  K IL
Sbjct: 242 GPLLRTSIHQNSGGQKSQNTGLTTKKFYGNN-VEKVPIDIIVNCDDSKHTYLQTNGKVIL 300

Query: 360 RGHN--------EGNQSLISA-EPIVVSSDEEG--------------PVEHKSSEILKLQ 396
            G          E   SL    +PI++SSD++               P +   S      
Sbjct: 301 PGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSACSSPAPST 360

Query: 397 SKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMEN--------------- 441
            K +    NEN   +E  L  +P    E  ++++   P    M++               
Sbjct: 361 GKVEA-ALNENTCRAERELRSIP----EDSELNTVTLPRKARMKDQFGNSIINTPLKRRK 415

Query: 442 ISSIMPSNEMDLQLDFIFTSVY-------IGKIKGASKGCVTITKKYIKIPF-QVSLNEI 493
           + S  P + + L     F SV        +G +       V     +IKI   +   + +
Sbjct: 416 VFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHDPV 475

Query: 494 SLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLEHS----------- 542
            ++++T+ L       +K +  + R   ++F        Q++  QL+ +           
Sbjct: 476 EIILNTSDL-------TKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKG 528

Query: 543 VLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQNL 602
           V    +   ++I L   N +     +  + I+ EI I +           +  F  F  +
Sbjct: 529 VNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIKNN----------ISNF--FAKI 576

Query: 603 SSKESSFIHYYCVSTCSFPA-GVAVAEEMKLKSVSQPSNTDA-AKPTYTFLQKQSSGCYS 660
             +E++     C  T      G    +E K+K+VS  S     +K  + F          
Sbjct: 577 PFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFD-------- 628

Query: 661 LSITSNPDEEWREVRHT---GLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIID 717
                  +EE     HT   G V+KLIVYPPPP KGG+ VTNEDL CL EGEFLNDVIID
Sbjct: 629 -------EEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIID 681

Query: 718 FYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRH 777
           FYLKYL+LEK   E  +R HIFSSFFYK L ++E     +  NLS+ Q+RH RV+TWTRH
Sbjct: 682 FYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERR-NHETTNLSIQQKRHGRVKTWTRH 740

Query: 778 INIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDN- 836
           ++IF KD+IFVP+NE++HW+LAV+CFP LE+  YE  P             ++N  I   
Sbjct: 741 VDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPKYEPNPH-----------YHENAVIQKC 789

Query: 837 DLRTTSTLSLSAEDSQSTESNMS----VPKKMCKRPCILILDSLKAASVQNTVQNLREYL 892
                S +S SA + +S   N S    + K + K+ CI ++DS      ++  +  R   
Sbjct: 790 STVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDS-NPGQEESDPRYKRNIC 848

Query: 893 EVEWEVKLKTH 903
            V++ VK   H
Sbjct: 849 SVKYSVKKINH 859



 Score =  149 bits (376), Expect = 1e-35
 Identities = 75/135 (55%), Positives = 99/135 (73%), Gaps = 1/135 (0%)

Query: 848  AEDSQSTE-SNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKLKTHRQF 906
            A+D+ S+E     +   +CK+PCIL++DSL+  S  N V+ LREYLEVEWEVK  + R F
Sbjct: 943  ADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSF 1002

Query: 907  SKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKRE 966
            SK  M    PKVP+Q+N SDCGVY+LQYVESFF++PI++FELP++L  WFP   ++TKRE
Sbjct: 1003 SKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKRE 1062

Query: 967  DIRELILKLHLQQQK 981
            +IR +ILKL   Q K
Sbjct: 1063 EIRNIILKLQEDQSK 1077


>gi|156105701 SUMO1/sentrin specific peptidase 6 isoform 1 [Homo
           sapiens]
          Length = 1112

 Score =  209 bits (532), Expect = 1e-53
 Identities = 207/731 (28%), Positives = 317/731 (43%), Gaps = 142/731 (19%)

Query: 262 KKQEDDSTISTEFE-KPSENYHQDPKLPEEITTKPTKSDFTKLSSLNS---QELTLSNAT 317
           K +E +S +  E + K  +  H     P    +  +K   T L  L     Q +TL+ +T
Sbjct: 189 KTEESESQVEPEIKRKVQQKRHCSTYQPTPPLSPASKKCLTHLEDLQRNCRQAITLNEST 248

Query: 318 ---------------KSASAGSTTETVENSNSIDIVGISSLVEKDENE---LNTIEKPIL 359
                          KS + G TT+    +N ++ V I  +V  D+++   L T  K IL
Sbjct: 249 GPLLRTSIHQNSGGQKSQNTGLTTKKFYGNN-VEKVPIDIIVNCDDSKHTYLQTNGKVIL 307

Query: 360 RGHN--------EGNQSLISA-EPIVVSSDEEG--------------PVEHKSSEILKLQ 396
            G          E   SL    +PI++SSD++               P +   S      
Sbjct: 308 PGAKIPKITNLKERKTSLSDLNDPIILSSDDDDDNDRTNRRESISPQPADSACSSPAPST 367

Query: 397 SKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMEN--------------- 441
            K +    NEN   +E  L  +P    E  ++++   P    M++               
Sbjct: 368 GKVEA-ALNENTCRAERELRSIP----EDSELNTVTLPRKARMKDQFGNSIINTPLKRRK 422

Query: 442 ISSIMPSNEMDLQLDFIFTSVY-------IGKIKGASKGCVTITKKYIKIPF-QVSLNEI 493
           + S  P + + L     F SV        +G +       V     +IKI   +   + +
Sbjct: 423 VFSQEPPDALALSCQSSFDSVILNCRSIRVGTLFRLLIEPVIFCLDFIKIQLDEPDHDPV 482

Query: 494 SLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLEHS----------- 542
            ++++T+ L       +K +  + R   ++F        Q++  QL+ +           
Sbjct: 483 EIILNTSDL-------TKCEWCNVRKLPVVFLQAIPAVYQKLSIQLQMNKEDKVWNDCKG 535

Query: 543 VLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQNL 602
           V    +   ++I L   N +     +  + I+ EI I +           +  F  F  +
Sbjct: 536 VNKLTNLEEQYIILIFQNGLDPPANMVFESIINEIGIKNN----------ISNF--FAKI 583

Query: 603 SSKESSFIHYYCVSTCSFPA-GVAVAEEMKLKSVSQPSNTDA-AKPTYTFLQKQSSGCYS 660
             +E++     C  T      G    +E K+K+VS  S     +K  + F          
Sbjct: 584 PFEEANGRLVACTRTYEESIKGSCGQKENKIKTVSFESKIQLRSKQEFQFFD-------- 635

Query: 661 LSITSNPDEEWREVRHT---GLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIID 717
                  +EE     HT   G V+KLIVYPPPP KGG+ VTNEDL CL EGEFLNDVIID
Sbjct: 636 -------EEEETGENHTIFIGPVEKLIVYPPPPAKGGISVTNEDLHCLNEGEFLNDVIID 688

Query: 718 FYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRH 777
           FYLKYL+LEK   E  +R HIFSSFFYK L ++E     +  NLS+ Q+RH RV+TWTRH
Sbjct: 689 FYLKYLVLEKLKKEDADRIHIFSSFFYKRLNQRERR-NHETTNLSIQQKRHGRVKTWTRH 747

Query: 778 INIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDN- 836
           ++IF KD+IFVP+NE++HW+LAV+CFP LE+  YE  P             ++N  I   
Sbjct: 748 VDIFEKDFIFVPLNEAAHWFLAVVCFPGLEKPKYEPNPH-----------YHENAVIQKC 796

Query: 837 DLRTTSTLSLSAEDSQSTESNMS----VPKKMCKRPCILILDSLKAASVQNTVQNLREYL 892
                S +S SA + +S   N S    + K + K+ CI ++DS      ++  +  R   
Sbjct: 797 STVEDSCISSSASEMESCSQNSSAKPVIKKMLNKKHCIAVIDS-NPGQEESDPRYKRNIC 855

Query: 893 EVEWEVKLKTH 903
            V++ VK   H
Sbjct: 856 SVKYSVKKINH 866



 Score =  149 bits (376), Expect = 1e-35
 Identities = 75/135 (55%), Positives = 99/135 (73%), Gaps = 1/135 (0%)

Query: 848  AEDSQSTE-SNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKLKTHRQF 906
            A+D+ S+E     +   +CK+PCIL++DSL+  S  N V+ LREYLEVEWEVK  + R F
Sbjct: 950  ADDNCSSEIGQWHLKPTICKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKRSF 1009

Query: 907  SKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKRE 966
            SK  M    PKVP+Q+N SDCGVY+LQYVESFF++PI++FELP++L  WFP   ++TKRE
Sbjct: 1010 SKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILSFELPMNLANWFPPPRMRTKRE 1069

Query: 967  DIRELILKLHLQQQK 981
            +IR +ILKL   Q K
Sbjct: 1070 EIRNIILKLQEDQSK 1084


>gi|7657550 sentrin/SUMO-specific protease 1 [Homo sapiens]
          Length = 643

 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 54/252 (21%), Positives = 106/252 (42%), Gaps = 80/252 (31%)

Query: 695 LGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNL 754
           L +T +D++ L    +LND II+FY+  +++E++ ++ +   H F++FF+          
Sbjct: 450 LTITRKDIQTLNHLNWLNDEIINFYMN-MLMERSKEKGLPSVHAFNTFFFT--------- 499

Query: 755 TEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDF 814
                   +    ++ V+ WT+ +++F+ D + VP++   HW LAV+ F           
Sbjct: 500 -------KLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDF----------- 541

Query: 815 PQTVSQQSQAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILD 874
                                         +++  DS    +N           C ++L 
Sbjct: 542 ---------------------------RKKNITYYDSMGGINN---------EACRILLQ 565

Query: 875 SLKAASVQNTVQNLREYLEVEWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQY 934
            LK  S+    +  +E+    W++       FSK +      ++P+Q N SDCG++  +Y
Sbjct: 566 YLKQESID---KKRKEFDTNGWQL-------FSKKS------QIPQQMNGSDCGMFACKY 609

Query: 935 VESFFKDPIVNF 946
            +   KD  +NF
Sbjct: 610 ADCITKDRPINF 621


>gi|54607091 SUMO1/sentrin/SMT3 specific protease 2 [Homo sapiens]
          Length = 589

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 62/265 (23%), Positives = 109/265 (41%), Gaps = 86/265 (32%)

Query: 695 LGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNL 754
           L +T  D++ L+   +LND +I+FY+  L++E+   +     H+FS+FFY          
Sbjct: 395 LRITRGDIQTLKNYHWLNDEVINFYMN-LLVERNKKQGYPALHVFSTFFY---------- 443

Query: 755 TEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDF 814
               P L      ++ V+ WT+ +N+F ++ I VP++   HW L VI             
Sbjct: 444 ----PKLKSGG--YQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVI------------- 484

Query: 815 PQTVSQQSQAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILD 874
                                 DLR      L   DS   + +         R C ++L 
Sbjct: 485 ----------------------DLRKK---CLKYLDSMGQKGH---------RICEILLQ 510

Query: 875 SL--KAASVQNTVQNLREYLEVEWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLL 932
            L  ++ + +N+  NL     +EW     TH             ++P+Q N SDCG++  
Sbjct: 511 YLQDESKTKRNSDLNL-----LEW-----THHSMKP-------HEIPQQLNGSDCGMFTC 553

Query: 933 QYVESFFKDPIVNF---ELPIHLEK 954
           +Y +   +D  + F   ++P+  +K
Sbjct: 554 KYADYISRDKPITFTQHQMPLFRKK 578


>gi|159032029 SUMO1/sentrin specific peptidase 5 [Homo sapiens]
          Length = 755

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 53/235 (22%), Positives = 90/235 (38%), Gaps = 86/235 (36%)

Query: 700 EDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNP 759
           +DL  L+   +LND +I+ Y + ++     D + ++ H F+SFF++ L  K  N      
Sbjct: 572 DDLATLDGQNWLNDQVINMYGELIM-----DAVPDKVHFFNSFFHRQLVTKGYN------ 620

Query: 760 NLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVS 819
                      V+ WT+ +++F K  + +P++   HW L  +                  
Sbjct: 621 ----------GVKRWTKKVDLFKKSLLLIPIHLEVHWSLITV------------------ 652

Query: 820 QQSQAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAA 879
                               T S   +S  DSQ       +  K C              
Sbjct: 653 --------------------TLSNRIISFYDSQ------GIHFKFC-------------- 672

Query: 880 SVQNTVQNLREYLEVEWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQY 934
                V+N+R+YL    E + K   +F +     +   +P+Q N SDCGV++LQY
Sbjct: 673 -----VENIRKYLLT--EAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQY 720


>gi|21361499 SUMO1/sentrin/SMT3 specific protease 3 [Homo sapiens]
          Length = 574

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 21/102 (20%)

Query: 697 VTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTE 756
           +T +DL  L    +LND +++ Y   ++     D + E+ H F+SFFY  L  K      
Sbjct: 388 LTMDDLGTLYGQNWLNDQVMNMYGDLVM-----DTVPEKVHFFNSFFYDKLRTKG----- 437

Query: 757 DNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYL 798
                      +  V+ WT++++IFNK+ + +P++   HW L
Sbjct: 438 -----------YDGVKRWTKNVDIFNKELLLIPIHLEVHWSL 468


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 56/297 (18%), Positives = 117/297 (39%), Gaps = 12/297 (4%)

Query: 120  NDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQS-LNLSERGSQRSKTVDDNSAKQTA 178
            + +N  D++     S  S S DS ++    +    S  N S   S  S + + + +  ++
Sbjct: 748  DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSS 807

Query: 179  HNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTK 238
             + +     D  S   SD+     +S S         S + D   SDS       +R   
Sbjct: 808  DSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS------NRSDS 861

Query: 239  RRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKS 298
                ++   S    S D S      +  +S+ S++    S++   D     + +     S
Sbjct: 862  SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS 921

Query: 299  DFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGIS-SLVEKDENELNTIEKP 357
            D    SS +S     SN++ S+++  ++++ ++SNS D    S S    D ++ N+ +  
Sbjct: 922  D----SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977

Query: 358  ILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESA 414
                 ++ + S  S++    S          SS+     +  D   ++++ ++S+S+
Sbjct: 978  DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 52/289 (17%), Positives = 105/289 (36%), Gaps = 19/289 (6%)

Query: 126 DANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRR 185
           D++   SDS  S+  DS ++    +    S +     S  S     +S+K  + + +   
Sbjct: 579 DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS 638

Query: 186 KDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNL 245
           K D      SD+   D +  S   D     + +     SDS    +           ++ 
Sbjct: 639 KSDS-----SDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSS 693

Query: 246 PDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSS 305
             S    S D S        D S  S      S++ +         ++  + S  +  SS
Sbjct: 694 DSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753

Query: 306 LNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNEG 365
            +S     SN++ S+ +  ++++ ++SNS D            +  N+ +       ++ 
Sbjct: 754 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD----------SNDSSNSSDSSDSSNSSDS 803

Query: 366 NQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESA 414
           + S  S++    SSD        SS+        D   ++++  +S+S+
Sbjct: 804 SNSSDSSD----SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848



 Score = 39.7 bits (91), Expect = 0.014
 Identities = 55/303 (18%), Positives = 111/303 (36%), Gaps = 12/303 (3%)

Query: 120 NDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAH 179
           +D++    +   SDS  S S DS ++         S N S+     + +   +S+  +  
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNS 752

Query: 180 NKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKR 239
           +      D   S   SD+     +S S         S + D   S +  + +  S  +  
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812

Query: 240 RLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSD 299
              ++  DS    S D S         +S+ S++    S+    D     + +     SD
Sbjct: 813 ---SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869

Query: 300 FTKLS-------SLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDE--NE 350
            +  S       S +S E + S+ +  +S  S +++ ++SNS D    S+  +  E  N 
Sbjct: 870 SSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNS 929

Query: 351 LNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENEST 410
            +          ++ + S  S+     S+  +      SS+     S     +++ ++S+
Sbjct: 930 SDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989

Query: 411 SES 413
             S
Sbjct: 990 DSS 992



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 53/296 (17%), Positives = 108/296 (36%), Gaps = 10/296 (3%)

Query: 120  NDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAH 179
            + +N  D++   SDS  S S DS ++    +    S +     S  S    D+S    + 
Sbjct: 955  DSSNSSDSSN-SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013

Query: 180  NKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKR 239
            +          S   + +   D +  S   D  +    +     SDS             
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073

Query: 240  RLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENY-HQDPKLPEEITTKPTKS 298
               ++   S+   S D S         DS+ S++    S++    D     + +     S
Sbjct: 1074 DSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133

Query: 299  DFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPI 358
            D    SS +S     S++++S+ +  ++++ ++S+S D    SS      +  N+ +   
Sbjct: 1134 D----SSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSD----SSDSSDSSDSSNSSDSSD 1185

Query: 359  LRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESA 414
                ++ + S  S++    S   +      SS+        D   +NE+  +S+S+
Sbjct: 1186 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSS 1241



 Score = 38.1 bits (87), Expect = 0.041
 Identities = 52/290 (17%), Positives = 109/290 (37%), Gaps = 17/290 (5%)

Query: 131 QSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGI 190
           +SDS  S S DS +     +    S   S   S  S + D +S+  ++++ +     D  
Sbjct: 639 KSDSSDSNSSDSSDNSDSSDSSNSSN--SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSS 696

Query: 191 -SLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQ 249
            S   SD+     +  S   D     S + D   S    + +  S  +     +N  DS 
Sbjct: 697 NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSS 756

Query: 250 YCTSLDKSTEQTKKQE-----DDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLS 304
             +    S++ +   +     D S  S   +  + +   D     + +     SD +  S
Sbjct: 757 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816

Query: 305 SLNSQELT-LSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHN 363
             +S   +  SN++ S+ + +++++ ++S+S D          D +  N  +       +
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD--------GSDSDSSNRSDSSNSSDSS 868

Query: 364 EGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSES 413
           + + S  S++    S   E      SS+          +++N ++S+  S
Sbjct: 869 DSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSS 918



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 46/260 (17%), Positives = 98/260 (37%), Gaps = 11/260 (4%)

Query: 159 SERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRN 218
           S+ G  +S + D +S+  +  +      D       SD+   + +S S   D    +S +
Sbjct: 540 SDSGKGKSDSSDSDSSDSSNSSDSSDSSD-------SDSSDSNSSSDSDSSDSDSSDSSD 592

Query: 219 KDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPS 278
            D   S +  + +  S  +     ++  DS+  +S  +S       + DS+ S   +   
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652

Query: 279 ENYHQDPKLPEEITTKPTKSDFTKLS----SLNSQELTLSNATKSASAGSTTETVENSNS 334
            +   D       +     SD +  S    S NS + + S+ + ++S  S +    +S+S
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712

Query: 335 IDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILK 394
            D    S+    D +  N+ +       ++ + S  S+     S   +      SS+   
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772

Query: 395 LQSKQDRETTNENESTSESA 414
                D   ++++  +S S+
Sbjct: 773 SSDSSDSSNSSDSNDSSNSS 792



 Score = 37.7 bits (86), Expect = 0.053
 Identities = 54/293 (18%), Positives = 111/293 (37%), Gaps = 11/293 (3%)

Query: 122  ANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNK 181
            +N  D +     S  S S DS ++    +    S N S+  S  S + D NS+  +  + 
Sbjct: 927  SNSSDNSNSSDSSNSSDSSDSSDSSNSSD----SSNSSD-SSNSSDSSDSNSSDSSDSSN 981

Query: 182  EKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRL 241
                 D   S   SD+     +S S         S + D   S      +  S  +    
Sbjct: 982  SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041

Query: 242  RNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFT 301
             ++  DS    S D S         DS+ S++    S++           ++  + S  +
Sbjct: 1042 SSDSSDSS--DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDS 1099

Query: 302  KLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRG 361
              SS +S     S+++ S+ + +++++ ++S+S D    SS      +  ++ E      
Sbjct: 1100 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD----SSDSSNSSDSSDSSESSDSSD 1155

Query: 362  HNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESA 414
             ++ + S  S++    S   +      SS+        D   ++++  +S+S+
Sbjct: 1156 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1208



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 51/268 (19%), Positives = 104/268 (38%), Gaps = 19/268 (7%)

Query: 126  DANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRR 185
            D++     S  S S DS ++    +    S   S   S+ S + D +++  ++ + +   
Sbjct: 1047 DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD--SSDSSESSDSSDSSNSSDSSDSSDSSD 1104

Query: 186  KDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNL 245
              D      SD+     +S S         S + D   S +  + +  S  +     ++ 
Sbjct: 1105 SSDS-----SDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDS 1159

Query: 246  PDSQYCT-SLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLS 304
             DS   + S D S         DS+ S++    S++           ++  + S  +  S
Sbjct: 1160 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1219

Query: 305  SLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEK--DENELNTIEKPILRGH 362
            S +S     S++ +S+ +  ++++ ++SNS D    S   +   D N+ +  +     G+
Sbjct: 1220 SDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGN 1279

Query: 363  NEGNQSLISAEPIVVSSDEEGPVEHKSS 390
            N G+ S          SD EG   + S+
Sbjct: 1280 NNGSDS---------DSDSEGSDSNHST 1298


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 67/321 (20%), Positives = 128/321 (39%), Gaps = 77/321 (23%)

Query: 144  ETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLN 203
            E C   + ++Q  N +  G ++SK + D ++K         +KD+     +SD   +   
Sbjct: 986  EICHFPKGIKQIKNGTTDGEKKSKKIRDKTSK---------KKDE-----LSDYAEKSTG 1031

Query: 204  SGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQY-------CTSLDK 256
             G   CD  E + ++K+  Y   K    L+ + +++R   +  D++        C S DK
Sbjct: 1032 KGD-SCDSSE-DKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDK 1089

Query: 257  -------------STEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKL 303
                         S+++  K+    + S++ E+ SE    D K  ++ T+   K+   K 
Sbjct: 1090 RLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE----DNKKKKQRTSSKKKAVIVKE 1145

Query: 304  SSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTI-EKPILRGH 362
               NS  L  S   K A   S++ +    +  + +G  S    DE ++  + E  +L  H
Sbjct: 1146 KKRNS--LRTSTKRKQADITSSSSSDIEDDDQNSIGEGS---SDEQKIKPVTENLVLSSH 1200

Query: 363  -----NEGNQSLISAEPIVV--------------------------SSDEEGPVEHKSSE 391
                 + G+++L  + P+ V                          SSDE+G  + +  E
Sbjct: 1201 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260

Query: 392  ILKLQSKQDRETTNENESTSE 412
              K   KQ+ E   + E+ ++
Sbjct: 1261 GKKRTGKQNEENPGDEEAKNQ 1281



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 64/299 (21%), Positives = 119/299 (39%), Gaps = 62/299 (20%)

Query: 118 PRNDANLCDANKVQSDSLPSTSV-----------DSLETCQKLEPLRQSLNLSERGSQRS 166
           P+  ++ C+  + + D   S SV           + ++  +KL  +  + N++    +  
Sbjct: 279 PKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKL--IETTANMNSSYVKFL 336

Query: 167 KTVDDNSAKQTAHNKEKRRKDDGISLLISDTQP------EDLNSGSRGCDHLEQESRNKD 220
           K   DNS   +A    K R+      +++D +       EDLNS  R  D + +E   K+
Sbjct: 337 KQATDNSEISSA---TKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKE 393

Query: 221 VKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSEN 280
            K  D+K E       TK R +   P +     + KS  +  +++ D          SE+
Sbjct: 394 HKVIDAKFE-------TKAR-KGEKPCALEKKDISKSEAKLSRKQVD----------SEH 435

Query: 281 YHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGI 340
            HQ+    E+ T K T  +  K       +   +N         T+E ++    +DIV +
Sbjct: 436 MHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPAN---------TSEDLD----MDIVSV 482

Query: 341 SSLVEKD--ENELNTIEKPILRGH----NEGNQSLISAEPI---VVSSDEEGPVEHKSS 390
            S V +D  EN    +E      H    + G +  + +  +   + S D  G ++ K++
Sbjct: 483 PSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTT 541



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 43/179 (24%), Positives = 74/179 (41%), Gaps = 10/179 (5%)

Query: 114  RKTLPRNDANLCDA---NKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVD 170
            ++T  +N+ N  D    N+V S+S  S S +S +   +   LR  L +S+  S   K   
Sbjct: 1263 KRTGKQNEENPGDEEAKNQVNSES-DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK 1321

Query: 171  DNSAKQT-AHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVE 229
                K+    N+ K   +D      SD Q   ++      +  EQ  R +  K ++ +  
Sbjct: 1322 PKEHKEVKGRNRRKVSSEDSED---SDFQESGVSEEVSESED-EQRPRTRSAKKAELEEN 1377

Query: 230  LTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLP 288
                 +K KRR      DS      +   E+ +K+E++     E E+  E+ + D K P
Sbjct: 1378 QRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEE-EEEEEEEEEDENDDSKSP 1435


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 67/321 (20%), Positives = 128/321 (39%), Gaps = 77/321 (23%)

Query: 144  ETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLN 203
            E C   + ++Q  N +  G ++SK + D ++K         +KD+     +SD   +   
Sbjct: 1024 EICHFPKGIKQIKNGTTDGEKKSKKIRDKTSK---------KKDE-----LSDYAEKSTG 1069

Query: 204  SGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQY-------CTSLDK 256
             G   CD  E + ++K+  Y   K    L+ + +++R   +  D++        C S DK
Sbjct: 1070 KGD-SCDSSE-DKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDK 1127

Query: 257  -------------STEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKL 303
                         S+++  K+    + S++ E+ SE    D K  ++ T+   K+   K 
Sbjct: 1128 RLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSE----DNKKKKQRTSSKKKAVIVKE 1183

Query: 304  SSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTI-EKPILRGH 362
               NS  L  S   K A   S++ +    +  + +G  S    DE ++  + E  +L  H
Sbjct: 1184 KKRNS--LRTSTKRKQADITSSSSSDIEDDDQNSIGEGS---SDEQKIKPVTENLVLSSH 1238

Query: 363  -----NEGNQSLISAEPIVV--------------------------SSDEEGPVEHKSSE 391
                 + G+++L  + P+ V                          SSDE+G  + +  E
Sbjct: 1239 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298

Query: 392  ILKLQSKQDRETTNENESTSE 412
              K   KQ+ E   + E+ ++
Sbjct: 1299 GKKRTGKQNEENPGDEEAKNQ 1319



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 64/299 (21%), Positives = 119/299 (39%), Gaps = 62/299 (20%)

Query: 118 PRNDANLCDANKVQSDSLPSTSV-----------DSLETCQKLEPLRQSLNLSERGSQRS 166
           P+  ++ C+  + + D   S SV           + ++  +KL  +  + N++    +  
Sbjct: 317 PKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKL--IETTANMNSSYVKFL 374

Query: 167 KTVDDNSAKQTAHNKEKRRKDDGISLLISDTQP------EDLNSGSRGCDHLEQESRNKD 220
           K   DNS   +A    K R+      +++D +       EDLNS  R  D + +E   K+
Sbjct: 375 KQATDNSEISSA---TKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNKEKNTKE 431

Query: 221 VKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSEN 280
            K  D+K E       TK R +   P +     + KS  +  +++ D          SE+
Sbjct: 432 HKVIDAKFE-------TKAR-KGEKPCALEKKDISKSEAKLSRKQVD----------SEH 473

Query: 281 YHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGI 340
            HQ+    E+ T K T  +  K       +   +N         T+E ++    +DIV +
Sbjct: 474 MHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPAN---------TSEDLD----MDIVSV 520

Query: 341 SSLVEKD--ENELNTIEKPILRGH----NEGNQSLISAEPI---VVSSDEEGPVEHKSS 390
            S V +D  EN    +E      H    + G +  + +  +   + S D  G ++ K++
Sbjct: 521 PSSVPEDIFENLETAMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTT 579



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 43/179 (24%), Positives = 74/179 (41%), Gaps = 10/179 (5%)

Query: 114  RKTLPRNDANLCDA---NKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVD 170
            ++T  +N+ N  D    N+V S+S  S S +S +   +   LR  L +S+  S   K   
Sbjct: 1301 KRTGKQNEENPGDEEAKNQVNSES-DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTK 1359

Query: 171  DNSAKQT-AHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVE 229
                K+    N+ K   +D      SD Q   ++      +  EQ  R +  K ++ +  
Sbjct: 1360 PKEHKEVKGRNRRKVSSEDSED---SDFQESGVSEEVSESED-EQRPRTRSAKKAELEEN 1415

Query: 230  LTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLP 288
                 +K KRR      DS      +   E+ +K+E++     E E+  E+ + D K P
Sbjct: 1416 QRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEE-EEEEEEEEEDENDDSKSP 1473


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 102/521 (19%), Positives = 193/521 (37%), Gaps = 65/521 (12%)

Query: 2   DKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPL 61
           D++   +  +  EI+ E KR+K   + +EI+++ N+   D       SK  S E      
Sbjct: 3   DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD-------SKRDSLE------ 49

Query: 62  QWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRND 121
             E  LR+  + +  +N  + R   +  +   +  L +         + RK  K   R D
Sbjct: 50  --EGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQ----QMSRK-EKVHHRKD 102

Query: 122 ANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNK 181
               +    +               ++ E  R+  +  E+   R +       +    + 
Sbjct: 103 EKRKEKKHARVKE------------KEREHERRKRHREEQDKARREWERQKRREMAREHS 150

Query: 182 EKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRL 241
            + R +DG+ L   D   +      R     EQ+   ++ K  + + E     R+ +R  
Sbjct: 151 RRERGNDGVCLF-RDRLEQLERKRERERKMREQQKEQREQKERERRAE----ERRKEREA 205

Query: 242 RNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFT 301
           R  +         D S +        S      E+      + P   E++  +   SD  
Sbjct: 206 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 265

Query: 302 KLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRG 361
            +S  +S+  T S  + SA +GS +E  E     +    S+  E +E E    E+    G
Sbjct: 266 DIS--DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 323

Query: 362 HNEGNQSLISAEPI---VVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSE------ 412
            N    S  SAE +    +S DEE   E+++  ++  +S+ DR++    E+  E      
Sbjct: 324 SNSEEASEQSAEEVSEEEMSEDEER--ENENHLLVVPESRFDRDSGESEEAEEEVGEGTP 381

Query: 413 --SALLELPLI----TCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGK 466
             SAL E   +        +++  EL  Y P ++   S+     ++   +  +  VY  K
Sbjct: 382 QSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAK 441

Query: 467 IKGASKGCVTITKKYIKIPFQ------VSLNEISLLVDTTH 501
            K   +    +  K +K+  +       SL EI+ ++   H
Sbjct: 442 DKKTDE---IVALKRLKMEKEKEGFPITSLREINTILKAQH 479


>gi|56676335 RAP1 interacting factor 1 [Homo sapiens]
          Length = 2472

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 67/329 (20%), Positives = 135/329 (41%), Gaps = 53/329 (16%)

Query: 124  LCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNL-------SERGSQRSKTVDDNSAKQ 176
            L D+  V  +SL  T  +  E   K+E   +++ +       +E   +++KT++ N   +
Sbjct: 1866 LGDSKNVSQESL-ETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELNVGNE 1924

Query: 177  TAHNKEKRRKDDGIS--LLISDTQPED---LNSGSRGCDHLEQESRNKDVKYSDSK--VE 229
             + + ++R K  GIS    I + +  D    ++       +  E  N D+  SD+   V+
Sbjct: 1925 ASFHGQERTKT-GISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTTPVK 1983

Query: 230  LTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPE 289
            L   +  +++     L      + L  S E   K +++  +    E  +E  H      E
Sbjct: 1984 LNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIG-EAMAETGHDGETENE 2042

Query: 290  EITTKPTKSDFTKLSSLN-------------SQELTLSNATKSASAGSTTETVENSNSID 336
             ITTK +K D  + + L              S E  + +A K+ +    +++ E  ++  
Sbjct: 2043 GITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDNNQ 2102

Query: 337  IVGISSLVEKDENELNTIEKP-------------ILRGHNEGNQSLISAEPIVVSSDEE- 382
            +V  S ++++D +    +E+P             I+  +N   Q L   +P +VS+++  
Sbjct: 2103 MVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSANDSP 2162

Query: 383  ---------GPVEHKSSEILKLQSKQDRE 402
                      P+   S+ ILK   K+ +E
Sbjct: 2163 SGMQTRCVWSPLASPSTSILKRGLKRSQE 2191



 Score = 37.4 bits (85), Expect = 0.070
 Identities = 62/292 (21%), Positives = 119/292 (40%), Gaps = 47/292 (16%)

Query: 148  KLEPLRQSLNLSERGSQRSKTVD---DNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNS 204
            ++ P +++L  S R  +RS+ V+   ++  K+ +H K++RRK++   L  S         
Sbjct: 1406 QITPNQKTLRRSSR--RRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPL------- 1456

Query: 205  GSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYC-TSLDKSTEQTKK 263
                  H++ +   K    ++  ++  LI +       +NL +     TS +  TEQ KK
Sbjct: 1457 ------HIKDDVLPKQKLIAEQTLQENLIEK------GSNLHEKTLGETSANAETEQNKK 1504

Query: 264  QEDDSTISTEFEKPSENYHQ-DPKLPEEITTKPT-KSDFTKLSSLNSQELTLSNATKSAS 321
            + D   I +E +   +   +   KL    T   T ++    LSS+ + E   S A +  S
Sbjct: 1505 KADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAKEEGS 1564

Query: 322  AGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAE-------P 374
                +   +N +       +  V+  + E   +++  ++  N+ +    ++E       P
Sbjct: 1565 RKKRSGKWKNKS-------NESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSP 1617

Query: 375  IVVSSDEEGPVEHKSSEILK--LQSKQDR----ETTNENESTSESALLELPL 420
            I    DE   V  + S +    LQ   D     E  NE    +E +   LP+
Sbjct: 1618 ICEKQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPV 1669



 Score = 35.0 bits (79), Expect = 0.35
 Identities = 73/382 (19%), Positives = 151/382 (39%), Gaps = 39/382 (10%)

Query: 70   KVISLDHKNKKHIR---GCPVTS-KSSPERQLKVMLTNVLWTDLG----RKFRKTLPRND 121
            + +   HK  + +R   GC     KS P+ +  + L N    D+     +K     P + 
Sbjct: 1714 QTLECQHKRSRRVRRSKGCDCCGEKSQPQEKSLIGLKNTENNDVEISETKKADVQAPVSP 1773

Query: 122  ANLCDANKVQSDSLPST--SVD-SLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTA 178
            +    AN            SV+  L   +  + +  SL +SE  S+ + T+ ++      
Sbjct: 1774 SETSQANPYSEGQFLDEHHSVNFHLGLKEDNDTINDSLIVSETKSKEN-TMQESLPSGIV 1832

Query: 179  HNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTK 238
            + +E+    D    +  ++Q E  N   +       +S+N   +  ++K E    + K +
Sbjct: 1833 NFREEICDMDSSEAMSLESQ-ESPNENFKTVGPCLGDSKNVSQESLETKEEKPEETPKME 1891

Query: 239  RRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEF---EKPSENYHQDPKLPEEITTKP 295
              L N   +   C   + + E+ K  E +      F   E+      ++  + E      
Sbjct: 1892 LSLENVTVEGNACKVTESNLEKAKTMELNVGNEASFHGQERTKTGISEEAAIEENKRNDD 1951

Query: 296  TKSDFTKLSSLN------SQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDEN 349
            +++D  KL++        + +++LS+ T      + TE  E + + ++ G       D +
Sbjct: 1952 SEADTAKLNAKEVATEEFNSDISLSDNTTPVKLNAQTEISEQTAAGELDG-----GNDVS 2006

Query: 350  ELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENES 409
            +L++ E+   +  N  N+ ++  E +   +  +G  E++   I    SK D   TN    
Sbjct: 2007 DLHSSEETNTKMKN--NEEMMIGEAMA-ETGHDGETENEG--ITTKTSKPDEAETN---- 2057

Query: 410  TSESALLELPLITCESVQMSSE 431
                   E+    C++V+MS+E
Sbjct: 2058 ---MLTAEMDNFVCDTVEMSTE 2076


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 111/545 (20%), Positives = 202/545 (37%), Gaps = 111/545 (20%)

Query: 2   DKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPL 61
           D++   +  +  EI+ E KR+K   + +EI+++ N+   D       SK  S E      
Sbjct: 3   DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD-------SKRDSLE------ 49

Query: 62  QWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRND 121
             E  LR      DH+ +  IR  P   + S E             D G +      +  
Sbjct: 50  --EGELR------DHRMEITIRNSPYRREDSME-------------DRGEEDDSLAIKPP 88

Query: 122 ANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNK 181
             +    KV                +K +  R+  + S  G + ++  +    K+  H +
Sbjct: 89  QQMSRKEKVHH-----------RKDEKRKEKRRHRSHSAEGGKHARVKE----KEREHER 133

Query: 182 EKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRL 241
            KR +++       D    +     R     E   R +D      ++E     R+ +R++
Sbjct: 134 RKRHREE------QDKARREWERQKRREMAREHSRRERD------RLEQLERKRERERKM 181

Query: 242 RNNLPDSQYCTSLDKSTEQTKKQ-EDDSTISTEFEKPSENY----------HQDPKLPEE 290
           R    + +     ++  E+ +K+ E    +S       E+Y             P+ P E
Sbjct: 182 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE 241

Query: 291 ITT-----KPTKSDFTK----LSSL----NSQELTLSNATKSASAGSTTETVENSNSIDI 337
                   KP K +  +    LS L    +S+  T S  + SA +GS +E  E     + 
Sbjct: 242 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 301

Query: 338 VGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPI---VVSSDEEGPVEHKSSEILK 394
              S+  E +E E    E+    G N    S  SAE +    +S DEE   E+++  ++ 
Sbjct: 302 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER--ENENHLLVV 359

Query: 395 LQSKQDRETTNENESTSE--------SALLELPLI----TCESVQMSSELCPYNPVMENI 442
            +S+ DR++    E+  E        SAL E   +        +++  EL  Y P ++  
Sbjct: 360 PESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGC 419

Query: 443 SSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQ------VSLNEISLL 496
            S+     ++   +  +  VY  K K   +    +  K +K+  +       SL EI+ +
Sbjct: 420 RSVEEFQCLNRIEEGTYGVVYRAKDKKTDE---IVALKRLKMEKEKEGFPITSLREINTI 476

Query: 497 VDTTH 501
           +   H
Sbjct: 477 LKAQH 481


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 89/432 (20%), Positives = 160/432 (37%), Gaps = 38/432 (8%)

Query: 20   KRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPLQWERSLRNKVISLDHKNK 79
            + K S SD S   K  +   E     SP S+ RSS   +    + RS R+   S      
Sbjct: 667  REKNSESDQSTYSKYSDRSSES----SPRSRSRSSRSRSYSRSYTRS-RSLASSHSRSRS 721

Query: 80   KHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCDANKVQSDSLPST- 138
               R       S   +  +      + +D GR+ ++ L  +      ++K  S S   T 
Sbjct: 722  PSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTL 781

Query: 139  ------SVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISL 192
                    D     +K    R SL+ S    Q S       A Q+A  KEK+ + +    
Sbjct: 782  HSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSV-----QATQSAQEKEKQGQMERTHN 836

Query: 193  LISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCT 252
                 + E+ +   R C H ++ +  +++  SD         R   +  R N   S++ +
Sbjct: 837  KQEKNRGEEKSKSERECPHSKKRTLKENL--SDHL-------RNGSKPKRKNYAGSKWDS 887

Query: 253  SLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPE-EITTKPT--KSDFTKLSSLNSQ 309
              +   + TK  ++DS  S++ E+       + ++ E  I  KPT   S  T L   N  
Sbjct: 888  ESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGA 947

Query: 310  ELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNE----- 364
              +    T ++ +  +    EN+            E  + E     K  L+G  +     
Sbjct: 948  WKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKA 1007

Query: 365  --GNQSLISAEPIVVSSDEEGPVEHK--SSEILKLQSKQDRETTNENESTSESALLELPL 420
                Q+     P+    +EE  ++ K  + E  + +  ++ ET  +N   +E +  E   
Sbjct: 1008 PKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLS 1067

Query: 421  ITCESVQMSSEL 432
               ++V +SS+L
Sbjct: 1068 GKHDTVTVSSDL 1079


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 61/260 (23%), Positives = 100/260 (38%), Gaps = 31/260 (11%)

Query: 213  EQESRNKDVKYSDSKVELTL-------ISRKTKRRL----------RNNLPDSQYCTSLD 255
            E+  R +D   +D+  EL         + R+  R L          + +L + Q  T  +
Sbjct: 992  EESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEE 1051

Query: 256  KSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSN 315
            +  E+ +++EDD    ++    SEN  +D  L E        SD         +E T+S 
Sbjct: 1052 EEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSD---------EEETVSI 1102

Query: 316  ATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNE--GNQSLISAE 373
             T  A A S++E+ E+S        S    +DE E+   E+       E    +S+ SA 
Sbjct: 1103 VTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAG 1162

Query: 374  PIVVSSD-EEGPVEHKSSEI--LKLQSKQDRETTNENESTSESALLELPLITCESVQMSS 430
            P     D EE  +   +  +  L ++ + D ET         S L E PL         S
Sbjct: 1163 PEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADS 1222

Query: 431  ELCPYNPVMENISSIMPSNE 450
               P  P +    +++ S E
Sbjct: 1223 REPPEEPGLSQEGAMLLSPE 1242


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 92/473 (19%), Positives = 183/473 (38%), Gaps = 74/473 (15%)

Query: 124  LCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEK 183
            L  AN   +        D+++  ++LE  ++ L  ++R     + V+  +AK ++  K K
Sbjct: 1363 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKL--AQRLQDAEEAVEAVNAKCSSLEKTK 1420

Query: 184  RRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRN 243
             R  + I  L+ D +  +  + +     L+++ RN D               K     + 
Sbjct: 1421 HRLQNEIEDLMVDVERSNAAAAA-----LDKKQRNFD---------------KILAEWKQ 1460

Query: 244  NLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKL 303
               +SQ        +E    Q++  ++STE  K    Y +  +  E            K 
Sbjct: 1461 KYEESQ--------SELESSQKEARSLSTELFKLKNAYEESLEHLETF----------KR 1502

Query: 304  SSLNSQELTLSNATKSASAGSTT----ETVENSNSIDIVGISSLVEKDENELNTIEKPIL 359
             + N QE  +S+ T+    G       E V     ++ + + S +E+ E  L   E  IL
Sbjct: 1503 ENKNLQE-EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561

Query: 360  RGHNEGNQSLISAEPIVVSSDEEGPVEHKSSE--ILKLQSKQDRETTNENE-----STSE 412
            R   E NQ     E  +   DEE     ++ +  +  LQ+  D ET + NE        E
Sbjct: 1562 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621

Query: 413  SALLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASK 472
              L E+ +    + +M++E       ++++ S++   ++ L  D +       +     K
Sbjct: 1622 GDLNEMEIQLSHANRMAAEA---QKQVKSLQSLLKDTQIQLD-DAV-------RANDDLK 1670

Query: 473  GCVTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYL 532
              + I ++   +  Q  L E+  +V+ T   R    K  +    + S  +      +  L
Sbjct: 1671 ENIAIVERRNNL-LQAELEELRAVVEQTERSR----KLAEQELIETSERVQLLHSQNTSL 1725

Query: 533  QEIQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELE 585
               + ++E  +   QS+  E +         +  E K K  +T+ ++++ EL+
Sbjct: 1726 INQKKKMESDLTQLQSEVEEAV------QECRNAEEKAKKAITDAAMMAEELK 1772


>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
            sapiens]
          Length = 1393

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 53/202 (26%), Positives = 83/202 (41%), Gaps = 28/202 (13%)

Query: 229  ELTLISRKTKRRLRNNLPDSQYCTSLDKSTE--QTKKQEDDSTISTEFEKPSENYHQDPK 286
            E+T  SR         + + +   S  K TE  +T   ED +  S E   P+EN  + P 
Sbjct: 933  EITTPSRAEPTEHGERIANEKATPSPAKPTEHGETTVNEDTTPSSAE---PTENGERTPL 989

Query: 287  LPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEK 346
              E  TT PT+S  T+     + E T  +  +    G   E   ++N   I   +   E 
Sbjct: 990  ANENTTTSPTES--TEHGERTANEKTTPSPAEPTEHG---ERTPSANEKTIPSPAKPTEH 1044

Query: 347  DE-----NELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEH---------KSSEI 392
            +E     NE NT   P+ +    G ++ ++ E I +S   EGP EH         K +  
Sbjct: 1045 EEMTPSANE-NTTPSPV-KPTEHGEKTTLANEKITLS--PEGPTEHGAKTTSANEKITPS 1100

Query: 393  LKLQSKQDRETTNENESTSESA 414
            L   ++    TT+ N+  + SA
Sbjct: 1101 LAKPTEHGERTTSPNDKITSSA 1122


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 70/313 (22%), Positives = 121/313 (38%), Gaps = 50/313 (15%)

Query: 124  LCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEK 183
            L  AN   +        D+++  ++LE  ++ L  ++R  +  + V+  +AK ++  K K
Sbjct: 1361 LSKANSEVAQWRTKYETDAIQRTEELEEAKKKL--AQRLQEAEEAVEAVNAKCSSLEKTK 1418

Query: 184  RRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRN 243
             R  + I  L+ D +  +  + +     L+++ RN D               K     + 
Sbjct: 1419 HRLQNEIEDLMVDVERSNAAAAA-----LDKKQRNFD---------------KILAEWKQ 1458

Query: 244  NLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKL 303
               +SQ        +E    Q++  ++STE  K    Y +  +  E            K 
Sbjct: 1459 KYEESQ--------SELESSQKEARSLSTELFKLKNAYEESLEHLETF----------KR 1500

Query: 304  SSLNSQELTLSNATKSASAGSTT---ETVENSNSIDIVGISSLVEKDENELNTIEKPILR 360
             + N QE       +  S+G T    E V      + + + S +E+ E  L   E  ILR
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR 1560

Query: 361  GHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILK----LQSKQDRETTNENESTSESALL 416
               E NQ     E  +   DEE  +E      L+    LQ+  D ET + NE+      +
Sbjct: 1561 AQLEFNQIKAEIERKLAEKDEE--MEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM 1618

Query: 417  ELPLITCESVQMS 429
            E  L   E +Q+S
Sbjct: 1619 EGDLNEME-IQLS 1630


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 85/417 (20%), Positives = 164/417 (39%), Gaps = 63/417 (15%)

Query: 143 LETCQKLEPLRQSLNLSERGSQRS----KTVDDNSAKQTAHN-KEKRRKDDGISLLISDT 197
           +E   +  P R+  ++ +RG +      K     S K+  H+ K+++RK+      + + 
Sbjct: 58  MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER 117

Query: 198 QPEDLNSGSRGCDHLEQE---SRNKDVKYSDSKVELTLIS-----RKTKRRLRNNLPDSQ 249
           + E         D   +E    + +++    S+ E   +      R+ +R++R    + +
Sbjct: 118 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 177

Query: 250 YCTSLDKSTEQTKKQ-EDDSTISTEFEKPSENY----------HQDPKLPEEITT----- 293
                ++  E+ +K+ E    +S       E+Y             P+ P E        
Sbjct: 178 EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGR 237

Query: 294 KPTKSDFTK----LSSL----NSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVE 345
           KP K +  +    LS L    +S+  T S  + SA +GS +E  E     +    S+  E
Sbjct: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297

Query: 346 KDENELNTIEKPILRGHNEGNQSLISAEPI---VVSSDEEGPVEHKSSEILKLQSKQDRE 402
            +E E    E+    G N    S  SAE +    +S DEE   E+++  ++  +S+ DR+
Sbjct: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER--ENENHLLVVPESRFDRD 355

Query: 403 TTNENESTSE--------SALLELPLI----TCESVQMSSELCPYNPVMENISSIMPSNE 450
           +    E+  E        SAL E   +        +++  EL  Y P ++   S+     
Sbjct: 356 SGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQC 415

Query: 451 MDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQ------VSLNEISLLVDTTH 501
           ++   +  +  VY  K K   +    +  K +K+  +       SL EI+ ++   H
Sbjct: 416 LNRIEEGTYGVVYRAKDKKTDE---IVALKRLKMEKEKEGFPITSLREINTILKAQH 469


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 102/521 (19%), Positives = 196/521 (37%), Gaps = 65/521 (12%)

Query: 2   DKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPL 61
           D++   +  +  EI+ E KR+K   + +EI+++ N+   D       SK  S E      
Sbjct: 3   DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD-------SKRDSLE------ 49

Query: 62  QWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRND 121
             E  LR+  + +  +N  + R   +  +   +  L +     +        RK   R +
Sbjct: 50  --EGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKE 107

Query: 122 ANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNK 181
              C  +   ++      V   E  ++ +  R+  + + R  +R K       ++    +
Sbjct: 108 K--CRHHSHSAEGGKHARVKEREH-ERRKRHREEQDKARREWERQK-------RREMARE 157

Query: 182 EKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRL 241
             RR+ D +  L    + E            EQ+   ++ K  + + E     R+ +R  
Sbjct: 158 HSRRERDRLEQLERKRERERKMR--------EQQKEQREQKERERRAE----ERRKEREA 205

Query: 242 RNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFT 301
           R  +         D S +        S      E+      + P   E++  +   SD  
Sbjct: 206 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 265

Query: 302 KLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRG 361
            +S  +S+  T S  + SA +GS +E  E     +    S+  E +E E    E+    G
Sbjct: 266 DIS--DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 323

Query: 362 HNEGNQSLISAEPI---VVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSE------ 412
            N    S  SAE +    +S DEE   E+++  ++  +S+ DR++    E+  E      
Sbjct: 324 SNSEEASEQSAEEVSEEEMSEDEER--ENENHLLVVPESRFDRDSGESEEAEEEVGEGTP 381

Query: 413 --SALLELPLI----TCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGK 466
             SAL E   +        +++  EL  Y P ++   S+     ++   +  +  VY  K
Sbjct: 382 QSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAK 441

Query: 467 IKGASKGCVTITKKYIKIPFQ------VSLNEISLLVDTTH 501
            K   +    +  K +K+  +       SL EI+ ++   H
Sbjct: 442 DKKTDE---IVALKRLKMEKEKEGFPITSLREINTILKAQH 479


>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
          Length = 2479

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 93/455 (20%), Positives = 189/455 (41%), Gaps = 46/455 (10%)

Query: 13   SEIITEGKR-KKSSSDLSEIRKMLNAKPEDVHVQSPL-SKFRSSERWTLPLQWERSLRNK 70
            +E I++G R  +   DL  ++ M  A+ ++  +   L  K R  ER    +      +NK
Sbjct: 580  TENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIA---KFQNK 636

Query: 71   VISLDHKNKKHIRGCPVTSKSSPERQ----LKVMLTNVLWTDLGRKFRKTLPRNDANLCD 126
            +  L  +NK+   G     ++  E Q    +K   T+++   L R       +N   + D
Sbjct: 637  LKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696

Query: 127  AN---KVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEK 183
            A+   K Q D L   + +  +  +  E  ++++N S++ ++ +  +D +  K+T+  ++ 
Sbjct: 697  ASLHLKAQVDQLTGRNEELRQELR--ESRKEAINYSQQLAKANLKID-HLEKETSLLRQS 753

Query: 184  RRKD---DGISLL--ISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRK-T 237
               +    GI L   I+ +    +NS +    HL QE  NK+ K  + +  L   +RK  
Sbjct: 754  EGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFA 813

Query: 238  KRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITT---- 293
              R + +L   +Y +  +K T +T    +  TI  E  K  +   QD    +E       
Sbjct: 814  VIRHQQSLLYKEYLS--EKETWKT----ESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA 867

Query: 294  -KPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELN 352
             +    +  K+ + NS+++T+    + +     T  VE         +    EK +NEL 
Sbjct: 868  LQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQ-----LRKENEKQKNELL 922

Query: 353  TIEKPIL-------RGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTN 405
            ++E  +        R        + + + +V +S     +E  + +  +L +K       
Sbjct: 923  SMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQK 982

Query: 406  ENESTSESALLELPLITCESVQMSSELCPYNPVME 440
            +N     ++ LE   + CE++ +  ++   N  +E
Sbjct: 983  DNMLVQRTSNLE--HLECENISLKEQVESINKELE 1015


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 67/306 (21%), Positives = 118/306 (38%), Gaps = 36/306 (11%)

Query: 115 KTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSA 174
           KT  +N+A+         +     S  S ET  + +    S  +S+  SQ+ K    NS 
Sbjct: 151 KTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQ---NSKTVSKNCSQKDKKDSKNSK 207

Query: 175 KQTA---HNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHL------EQESRNKDV---- 221
           K      H K   +KD   S   +D   E  +  S   D L      + ES N D     
Sbjct: 208 KTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRN 267

Query: 222 -KYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSEN 280
              ++SK      ++ TK+  + N   S      D  +E +K  + DS      +K  +N
Sbjct: 268 YSQNNSKNYSLKYTKYTKKDTKKNAKKSS-----DAESEDSKDAKKDS------KKVKKN 316

Query: 281 YHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGI 340
             +D K  +++      +D     S + ++ T  +  K        +T +   S D    
Sbjct: 317 VKKDDK-KKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTE-- 373

Query: 341 SSLVEKDENELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQD 400
           S   +   N+   ++K      ++ +     A+ I  S+D E  +E K S+  + + K+D
Sbjct: 374 SGDAKDARNDSRNLKKA-----SKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKD 428

Query: 401 RETTNE 406
            +T N+
Sbjct: 429 SKTDNK 434



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 66/340 (19%), Positives = 129/340 (37%), Gaps = 54/340 (15%)

Query: 2   DKRKLG----RRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERW 57
           D +K G      P S +I+ E  ++++ +D + ++          H      K +SS   
Sbjct: 130 DSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSS--------HENEQSKKSKSSSET 181

Query: 58  TLPLQWERSLRNKVISLDHKNKKHIRGCPVT---SKSSPERQLKVMLTNVLWTDLGRKFR 114
               Q  +++       D K+ K+ +        +K++P++ LK   T+           
Sbjct: 182 NPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTS----------- 230

Query: 115 KTLPRND--ANLCDANKVQSDSL--------PSTSVDS-LETCQKLEPLRQSLNLSE--- 160
                ND  + +C  N +  D L         S + D+ L    +      SL  ++   
Sbjct: 231 -----NDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTK 285

Query: 161 -------RGSQRSKTVDDNSAKQTAHNKEKR-RKDDGISLLISDTQPEDLNSGSRGCDHL 212
                  + S  +++ D   AK+ +   +K  +KDD    +  DT+  D  SG    +  
Sbjct: 286 KDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERK 345

Query: 213 EQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTIST 272
           + +   K +K  D K +       T     +         +L K+++   K++D   I+ 
Sbjct: 346 DTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITF 405

Query: 273 EFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQELT 312
             +  SE   ++ +  E+   K +K+D  K S  N +E T
Sbjct: 406 STDSESELESKESQKDEKKDKKDSKTD-NKKSVKNDEEST 444


>gi|87299628 biorientation of chromosomes in cell division 1-like
            [Homo sapiens]
          Length = 3051

 Score = 40.8 bits (94), Expect = 0.006
 Identities = 86/431 (19%), Positives = 165/431 (38%), Gaps = 57/431 (13%)

Query: 2    DKRKLGRRPSSSEIITEGKRKKSSSDLSEIRK-MLNAKPEDVHVQSPLSKFRSSERWTLP 60
            +  K  RR S+ +   E K ++SS   S+I+K  L +K   + +Q     +   +     
Sbjct: 823  ENNKKERRLSAEKTKAEHKSRRSSD--SKIQKDSLGSKQHGITLQRRSESYSEDKCDMDS 880

Query: 61   LQWERSLRNKVISLDHKNKKHIRGC-----PVTSKSSPE-RQLKVMLTNVLWTDLGRKFR 114
               + +L+ + +   HK K+  +        + SKS  + +Q+KV+ T +     G   +
Sbjct: 881  TNMDSNLKPEEVV--HKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETEL---QEGATKQ 935

Query: 115  KTLPR---------NDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQR 165
             T P+         ND+     +KV+      T V         EP+ ++ + S   +Q+
Sbjct: 936  ATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGV---------EPVLETASSSAHSTQK 986

Query: 166  SKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSD 225
                D +   +    KEK + D   +    + +  D +  SR   H  ++ + KD   SD
Sbjct: 987  ----DSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHK-SRSLKHSSKDIKKKDENKSD 1041

Query: 226  SKVELTLISRKTKRRLRNNLPDS----QYCTSLDKSTEQTKKQEDDSTISTEFEKPSENY 281
             K    + S   K R  ++L +     + C +   S  Q   + ++   +     PS + 
Sbjct: 1042 DKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGSS 1101

Query: 282  HQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGIS 341
             Q PK            D T +      E+      ++    S T+   N+NS   +   
Sbjct: 1102 LQRPK---------KSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSE 1152

Query: 342  SLVEKDENELNTIEKPILRGHNEGNQSLISA----EPIVVSSDEEGPVEHKSSEILKLQS 397
            ++ +K      T++K  LR     +++   A        V+S+ E   +H+S+   K+  
Sbjct: 1153 NMKQKTS---ATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHI 1209

Query: 398  KQDRETTNENE 408
            +      N  E
Sbjct: 1210 QSAVSKMNPGE 1220



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 36/196 (18%), Positives = 86/196 (43%), Gaps = 17/196 (8%)

Query: 157  NLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQES 216
            +LS+  ++  + +  N+    + +  +R K  G   LI + +P +++S   G +++ + S
Sbjct: 1077 SLSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDS-EPGVENVFEVS 1135

Query: 217  RNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEK 276
            + +D + ++S+ ++   + K K        + + CT+  K+T    K    + +++  EK
Sbjct: 1136 KTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEK 1195

Query: 277  PSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSID 336
             +++                +S  TK   + S    ++   K      TTE   +S ++ 
Sbjct: 1196 HADH----------------RSTLTKKMHIQSAVSKMNPGEKEPIHRGTTEVNIDSETVH 1239

Query: 337  IVGISSLVEKDENELN 352
             + +S+  E D  + N
Sbjct: 1240 RMLLSAPSENDRVQKN 1255



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 86/441 (19%), Positives = 168/441 (38%), Gaps = 58/441 (13%)

Query: 8   RRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPLQWERSL 67
           ++P S+E   +G+RKK   + +E +   + K ED        + +  E  +L L  E++ 
Sbjct: 324 KKPDSNE---KGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKN- 379

Query: 68  RNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCDA 127
            NK  +++   +           S  +    + +++V  +DL      T         + 
Sbjct: 380 SNKAKTVEGTKEDFS-----LIDSDVDGLTDITVSSVHTSDLSSFEEDT---------EE 425

Query: 128 NKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSA-KQTAHNKEKRRK 186
             V SDS+    + S +  +K +  +     S+    ++K+V      K   ++K     
Sbjct: 426 EVVTSDSMEEGEITSDDE-EKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDS 484

Query: 187 DDGISL-----LISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSK--------VELTLI 233
           DD +++      I+  + E L       + LE++ + K  K   SK        V+L   
Sbjct: 485 DDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEES 544

Query: 234 SRKTKR----RLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPK--- 286
           S K+      R++  L + +    L+K    +KK++ DS    E  K  + Y +D K   
Sbjct: 545 STKSLEPKAARIKEVLKERKV---LEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETL 601

Query: 287 ------------LPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNS 334
                         +E+     KS+ +K +   S+ L + +  K+ S          S  
Sbjct: 602 KTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTP 661

Query: 335 IDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILK 394
           + + G+    +  + +       I     +  +S +  E  +   D E P  H  S +LK
Sbjct: 662 VIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETP--HLKS-LLK 718

Query: 395 LQSKQDRETTNENESTSESAL 415
            + K  +E     ++ SE  L
Sbjct: 719 KEVKSSKEKPEREKTPSEDKL 739



 Score = 31.2 bits (69), Expect = 5.0
 Identities = 36/195 (18%), Positives = 70/195 (35%), Gaps = 24/195 (12%)

Query: 126  DANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHN----- 180
            + N    + LP TS ++  T  ++   +   + SE   ++ +  DD++ K    +     
Sbjct: 2812 EENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIII 2871

Query: 181  KEKR-------------RKDDG---ISLLISDTQPEDLNSGSRGCDHLEQESRN---KDV 221
            K KR              KDD      ++  +  P          D   +E+ N   + +
Sbjct: 2872 KRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSI 2931

Query: 222  KYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENY 281
               D + ++    R+  R+ + +L  S    S +   ++ K   D      E E   E  
Sbjct: 2932 SNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEE 2991

Query: 282  HQDPKLPEEITTKPT 296
             ++   P   TT+ T
Sbjct: 2992 EEEEDEPSGATTRST 3006


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 40.4 bits (93), Expect = 0.008
 Identities = 99/521 (19%), Positives = 193/521 (37%), Gaps = 74/521 (14%)

Query: 2   DKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPL 61
           D++   +  +  EI+ E KR+K   + +EI+++ N+   D       SK  S E      
Sbjct: 3   DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD-------SKRDSLE------ 49

Query: 62  QWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRND 121
             E  LR+  + +  +N  + R   +  +   +  L +     +        RK   R +
Sbjct: 50  --EGELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKE 107

Query: 122 ANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNK 181
                  + + +             ++ +  R+  + + R  +R K       ++    +
Sbjct: 108 KKHARVKEKEREH------------ERRKRHREEQDKARREWERQK-------RREMARE 148

Query: 182 EKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRL 241
             RR+ D +  L    + E            EQ+   ++ K  + + E     R+ +R  
Sbjct: 149 HSRRERDRLEQLERKRERERKMR--------EQQKEQREQKERERRAE----ERRKEREA 196

Query: 242 RNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFT 301
           R  +         D S +        S      E+      + P   E++  +   SD  
Sbjct: 197 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 256

Query: 302 KLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRG 361
            +S  +S+  T S  + SA +GS +E  E     +    S+  E +E E    E+    G
Sbjct: 257 DIS--DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 314

Query: 362 HNEGNQSLISAEPI---VVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSE------ 412
            N    S  SAE +    +S DEE   E+++  ++  +S+ DR++    E+  E      
Sbjct: 315 SNSEEASEQSAEEVSEEEMSEDEER--ENENHLLVVPESRFDRDSGESEEAEEEVGEGTP 372

Query: 413 --SALLELPLI----TCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGK 466
             SAL E   +        +++  EL  Y P ++   S+     ++   +  +  VY  K
Sbjct: 373 QSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAK 432

Query: 467 IKGASKGCVTITKKYIKIPFQ------VSLNEISLLVDTTH 501
            K   +    +  K +K+  +       SL EI+ ++   H
Sbjct: 433 DKKTDE---IVALKRLKMEKEKEGFPITSLREINTILKAQH 470


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 40.0 bits (92), Expect = 0.011
 Identities = 81/400 (20%), Positives = 160/400 (40%), Gaps = 42/400 (10%)

Query: 24   SSSDLSEIRKMLNAKPEDVH-VQSPLSKFRSSERWTLPLQWERSLRNKVISLDHKN---- 78
            +SS L+++   L  K  DV  +Q  L+K   +  +      ++S+ +  +  +       
Sbjct: 894  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFL-----QKSIEDMTVKAEQSQQEAA 948

Query: 79   KKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRK----TLPRNDANLCDANKV---Q 131
            KKH        +   + + K+  ++    +L  ++ +    T  +++  L +  K     
Sbjct: 949  KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT 1008

Query: 132  SDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGIS 191
             D L     ++    Q+LE LR+  + ++     ++T +D  A Q      K + +   S
Sbjct: 1009 EDKLKGAREENSGLLQELEELRKQADKAKA----AQTAED--AMQIMEQMTKEKTETLAS 1062

Query: 192  LLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYC 251
            L   DT+  +    +   D L+ E+  K+V+  +   EL  +  +     R  +   +  
Sbjct: 1063 L--EDTKQTNAKLQNE-LDTLK-ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQA 1118

Query: 252  TSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQEL 311
             +  KS + +  QE++  ++ E  +  +      KL EE             S LN+Q L
Sbjct: 1119 AA-QKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE------------RSVLNNQLL 1165

Query: 312  TLSNATKSASAGSTTETVENSNSIDIVGISSLVEKD-ENELNTIEKPILRGHNEGNQSLI 370
             +          +  E      SI I   + L EKD E E    E  +LRG N   +SL 
Sbjct: 1166 EMKKRESKFIKDADEEKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLH 1224

Query: 371  SAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENEST 410
            S    + S   +  ++ K+ E+   ++K+   +++ N  T
Sbjct: 1225 SVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1264


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 40.0 bits (92), Expect = 0.011
 Identities = 81/400 (20%), Positives = 160/400 (40%), Gaps = 42/400 (10%)

Query: 24   SSSDLSEIRKMLNAKPEDVH-VQSPLSKFRSSERWTLPLQWERSLRNKVISLDHKN---- 78
            +SS L+++   L  K  DV  +Q  L+K   +  +      ++S+ +  +  +       
Sbjct: 929  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFL-----QKSIEDMTVKAEQSQQEAA 983

Query: 79   KKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRK----TLPRNDANLCDANKV---Q 131
            KKH        +   + + K+  ++    +L  ++ +    T  +++  L +  K     
Sbjct: 984  KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT 1043

Query: 132  SDSLPSTSVDSLETCQKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGIS 191
             D L     ++    Q+LE LR+  + ++     ++T +D  A Q      K + +   S
Sbjct: 1044 EDKLKGAREENSGLLQELEELRKQADKAKA----AQTAED--AMQIMEQMTKEKTETLAS 1097

Query: 192  LLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYC 251
            L   DT+  +    +   D L+ E+  K+V+  +   EL  +  +     R  +   +  
Sbjct: 1098 L--EDTKQTNAKLQNE-LDTLK-ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQA 1153

Query: 252  TSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQEL 311
             +  KS + +  QE++  ++ E  +  +      KL EE             S LN+Q L
Sbjct: 1154 AA-QKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE------------RSVLNNQLL 1200

Query: 312  TLSNATKSASAGSTTETVENSNSIDIVGISSLVEKD-ENELNTIEKPILRGHNEGNQSLI 370
             +          +  E      SI I   + L EKD E E    E  +LRG N   +SL 
Sbjct: 1201 EMKKRESKFIKDADEEKASLQKSISITS-ALLTEKDAELEKLRNEVTVLRGENASAKSLH 1259

Query: 371  SAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENEST 410
            S    + S   +  ++ K+ E+   ++K+   +++ N  T
Sbjct: 1260 SVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1299


>gi|20070262 TNF receptor-associated factor 3 interacting protein 1
           isoform 1 [Homo sapiens]
          Length = 691

 Score = 40.0 bits (92), Expect = 0.011
 Identities = 43/193 (22%), Positives = 73/193 (37%), Gaps = 11/193 (5%)

Query: 153 RQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHL 212
           +Q   L E    R K  D   AK+   N+ +  + +              + G+R  D  
Sbjct: 183 KQKEELKEDRKPREKDKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRD 242

Query: 213 EQESRNKDVKYSDSKVELTLISR-------KTKRRLRNNLPDSQYCTSLD--KSTEQTKK 263
            +  +  + K    K +  L  R       K K R R  + + ++   LD  K+ E  K 
Sbjct: 243 SERKKETERKSEGGKEKERLRDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKP 302

Query: 264 QEDDSTISTEFEKPSENYHQDPK--LPEEITTKPTKSDFTKLSSLNSQELTLSNATKSAS 321
           ++  ++     +K S+   +D K     EI+T+ +KS  TK S   S+         + S
Sbjct: 303 EKKSASSGEMSKKLSDGTFKDSKAETETEISTRASKSLTTKTSKRRSKNSVEGRKEDNIS 362

Query: 322 AGSTTETVENSNS 334
           A S    V   N+
Sbjct: 363 AKSLDSIVSGINN 375


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 40.0 bits (92), Expect = 0.011
 Identities = 82/400 (20%), Positives = 155/400 (38%), Gaps = 66/400 (16%)

Query: 147 QKLEPLRQSLNLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGS 206
           +K +  R+  + S  G + ++  +    K+  H + KR +++       D    +     
Sbjct: 69  EKRKEKRRHRSHSAEGGKHARVKE----KEREHERRKRHREE------QDKARREWERQK 118

Query: 207 RGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQ-E 265
           R     E   R +D      ++E     R+ +R++R    + +     ++  E+ +K+ E
Sbjct: 119 RREMAREHSRRERD------RLEQLERKRERERKMREQQKEQREQKERERRAEERRKERE 172

Query: 266 DDSTISTEFEKPSENY----------HQDPKLPEEITT-----KPTKSDFTK----LSSL 306
               +S       E+Y             P+ P E        KP K +  +    LS L
Sbjct: 173 ARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDL 232

Query: 307 ----NSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGH 362
               +S+  T S  + SA +GS +E  E     +    S+  E +E E    E+    G 
Sbjct: 233 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 292

Query: 363 NEGNQSLISAEPI---VVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSE------- 412
           N    S  SAE +    +S DEE   E+++  ++  +S+ DR++    E+  E       
Sbjct: 293 NSEEASEQSAEEVSEEEMSEDEER--ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQ 350

Query: 413 -SALLELPLI----TCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKI 467
            SAL E   +        +++  EL  Y P ++   S+     ++   +  +  VY  K 
Sbjct: 351 SSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKD 410

Query: 468 KGASKGCVTITKKYIKIPFQ------VSLNEISLLVDTTH 501
           K   +    +  K +K+  +       SL EI+ ++   H
Sbjct: 411 KKTDE---IVALKRLKMEKEKEGFPITSLREINTILKAQH 447


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 40.0 bits (92), Expect = 0.011
 Identities = 85/418 (20%), Positives = 163/418 (38%), Gaps = 64/418 (15%)

Query: 143 LETCQKLEPLRQSLNLSERGSQRS----KTVDDNSAKQTAHNK--EKRRKDDGISLLISD 196
           +E   +  P R+  ++ +RG +      K     S K+  H++  EKR++     +   +
Sbjct: 24  MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE 83

Query: 197 TQPEDLNSGSRGCDHLEQE---SRNKDVKYSDSKVELTLIS-----RKTKRRLRNNLPDS 248
            + E         D   +E    + +++    S+ E   +      R+ +R++R    + 
Sbjct: 84  REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQ 143

Query: 249 QYCTSLDKSTEQTKKQ-EDDSTISTEFEKPSENY----------HQDPKLPEEITT---- 293
           +     ++  E+ +K+ E    +S       E+Y             P+ P E       
Sbjct: 144 REQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 203

Query: 294 -KPTKSDFTK----LSSL----NSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLV 344
            KP K +  +    LS L    +S+  T S  + SA +GS +E  E     +    S+  
Sbjct: 204 RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 263

Query: 345 EKDENELNTIEKPILRGHNEGNQSLISAEPI---VVSSDEEGPVEHKSSEILKLQSKQDR 401
           E +E E    E+    G N    S  SAE +    +S DEE   E+++  ++  +S+ DR
Sbjct: 264 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER--ENENHLLVVPESRFDR 321

Query: 402 ETTNENESTSE--------SALLELPLI----TCESVQMSSELCPYNPVMENISSIMPSN 449
           ++    E+  E        SAL E   +        +++  EL  Y P ++   S+    
Sbjct: 322 DSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQ 381

Query: 450 EMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQ------VSLNEISLLVDTTH 501
            ++   +  +  VY  K K   +    +  K +K+  +       SL EI+ ++   H
Sbjct: 382 CLNRIEEGTYGVVYRAKDKKTDE---IVALKRLKMEKEKEGFPITSLREINTILKAQH 436


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,192,652
Number of Sequences: 37866
Number of extensions: 1591149
Number of successful extensions: 5005
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 175
Number of HSP's that attempted gapping in prelim test: 4771
Number of HSP's gapped (non-prelim): 411
length of query: 985
length of database: 18,247,518
effective HSP length: 112
effective length of query: 873
effective length of database: 14,006,526
effective search space: 12227697198
effective search space used: 12227697198
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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