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Search of human proteins with 23503325
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23503325 mirror-image polydactyly 1 [Homo sapiens]
(442 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23503325 mirror-image polydactyly 1 [Homo sapiens] 862 0.0
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 66 7e-11
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens] 64 2e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 64 2e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 64 2e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 64 2e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 64 2e-10
gi|55770834 centromere protein F [Homo sapiens] 64 2e-10
gi|122937396 coiled-coil domain containing 150 [Homo sapiens] 64 2e-10
gi|118498362 kinectin 1 isoform b [Homo sapiens] 64 3e-10
gi|118498356 kinectin 1 isoform a [Homo sapiens] 64 3e-10
gi|118498368 kinectin 1 isoform c [Homo sapiens] 64 3e-10
gi|33620775 kinectin 1 isoform a [Homo sapiens] 64 3e-10
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] 64 3e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 64 3e-10
gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens] 64 4e-10
gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens] 63 6e-10
gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens] 63 6e-10
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 63 6e-10
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 63 6e-10
gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens] 62 1e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 62 1e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 62 1e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 62 1e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 62 1e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 62 1e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 62 1e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 62 1e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 62 1e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 62 1e-09
>gi|23503325 mirror-image polydactyly 1 [Homo sapiens]
Length = 442
Score = 862 bits (2227), Expect = 0.0
Identities = 442/442 (100%), Positives = 442/442 (100%)
Query: 1 MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQR 60
MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQR
Sbjct: 1 MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQR 60
Query: 61 STNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKEL 120
STNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKEL
Sbjct: 61 STNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKEL 120
Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEA 180
DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEA
Sbjct: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEA 180
Query: 181 VMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
VMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN
Sbjct: 181 VMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH
Sbjct: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN
Sbjct: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
Query: 361 YTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ 420
YTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ
Sbjct: 361 YTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ 420
Query: 421 KLERLVDVLRKKVGTGTMRTVI 442
KLERLVDVLRKKVGTGTMRTVI
Sbjct: 421 KLERLVDVLRKKVGTGTMRTVI 442
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 65.9 bits (159), Expect = 7e-11
Identities = 72/369 (19%), Positives = 169/369 (45%), Gaps = 41/369 (11%)
Query: 103 VTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKL---KFKLELQEKETEAKI 159
+T + +K K++A L + + + T L+++L +E+K++++L + KLE + +I
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITD---LEERLRREEKQRQELEKTRRKLEGDSTDLSDQI 1064
Query: 160 AEKTAALVE-EVYFAQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN------ 211
AE A + E ++ A+KE + +A ++R++ +++ A+ + + +E + L+
Sbjct: 1065 AELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124
Query: 212 -----INPEENDM--TLQELLNRINNADTGIAIQKNGAI-----------IVDRIYKTKE 253
++ D+ L+ L + + A Q+ ++ KT E
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 254 CKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTS----ANNMRHLTA----EN 305
+++ ++ S +EE L + KR++ L K+ + AN ++ L
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYY-SLHKSLSQEENLKDQFNYTLS 364
++ + ++A+L +Q + +L +++ L+V ++ LSQ ++ + S
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 365 TYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLER 424
E L++ + ++ +Q L+T+L+Q E+ + QL+ EA +++ L
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 425 LVDVLRKKV 433
V ++KK+
Sbjct: 1365 QVADMKKKM 1373
Score = 63.9 bits (154), Expect = 3e-10
Identities = 80/319 (25%), Positives = 150/319 (47%), Gaps = 44/319 (13%)
Query: 123 LRTSNKKLQQ---KLAKEDKEQRKLKFKLELQEKETEAKI--AEKTAALVEEVYFAQKER 177
L+ KK+QQ +L ++ +E+ + KL+L++ TEAK+ E+ ++E+ +
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 178 DEAVMSRLQ------LAIEERDEAIARA--KHMEMSLKVLENINPEEND-MTLQELLNRI 228
+ + R+ EE+ +++A+ KH M + E + EE L++ ++
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 229 NNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVK 288
T ++ Q I + + E KM++ +E EE AAL+ R+E+E
Sbjct: 1054 EGDSTDLSDQ-----IAELQAQIAELKMQLAKKE-----EELQAALA---RVEEE----A 1096
Query: 289 EQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYY--SLH 346
Q + +R L ++ ++ L+ L S + +R A +Q + L EE++ L+ +L
Sbjct: 1097 AQKNMALKKIRELESQISE---LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLD 1153
Query: 347 KSLSQEE---NLKDQFNYTLSTYEEALKNRENIVSITQQQN----EELATQLQQALTERA 399
+ +Q+E + + N T EE K E + +Q++ EELA QL+Q +A
Sbjct: 1154 STAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKA 1213
Query: 400 NMELQLQH-AREASQVANE 417
N+E Q E ++ANE
Sbjct: 1214 NLEKAKQTLENERGELANE 1232
Score = 51.6 bits (122), Expect = 1e-06
Identities = 84/361 (23%), Positives = 152/361 (42%), Gaps = 67/361 (18%)
Query: 119 ELDILRTSNKKLQQKLAKEDKEQRKLK-----FKLELQEKETEAKIAEKTAALVE---EV 170
E++ L +S + + + + +K +R L+ K +L+E E E + E +E +
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 171 YFAQKERD-------------------EAVMSRLQLAIEERDEAIARAKHMEMSLKVLE- 210
AQ ERD + + L+ ++R A+A K +EM LK LE
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 211 -----NINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSA 265
N N +E L++L ++ + + + + K E K++ EM
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 266 LIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETA 325
L EE AA ++ +QE + ++ AN+ ++R L+A++
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADE---IANSSGKGALALEEKRRLEARI---------- 1731
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEENLK-DQFNYTLSTYEEALKNRENIVSITQQQN 384
+LEEE++ + L ++ NL+ DQ N L+ + EN ++QN
Sbjct: 1732 ----AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 385 EELATQLQQ--------------ALTER-ANMELQLQHAREASQVANEKVQKLE-RLVDV 428
+EL +LQ+ AL + A +E QL + + Q A ++V++ E +L DV
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847
Query: 429 L 429
L
Sbjct: 1848 L 1848
Score = 50.1 bits (118), Expect = 4e-06
Identities = 66/304 (21%), Positives = 123/304 (40%), Gaps = 34/304 (11%)
Query: 105 SDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTA 164
SDS K L K+ L + + Q+ L +E++++ L KL+ E E +
Sbjct: 1292 SDSKSSK----LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS------- 1340
Query: 165 ALVEEVYFAQKERDEAVMSRLQLAIEERDEAIA-RAKHMEMSLKVLENINPEENDMTLQE 223
+ Q E +E L+ I +A K ME S+ LE T +E
Sbjct: 1341 ------FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE---------TAEE 1385
Query: 224 LLNRINNADTGIAIQKNGAIIV-DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQ 282
+ ++ G++ + + D++ KTK + + + L +R +A + K+ ++
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445
Query: 283 ELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
+ E+ SA + R + K LS+ +A E A++Q +LE R+
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE------RLN 1499
Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANME 402
+ + KD ++ E++ + E V + Q EEL +LQ + +E
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 403 LQLQ 406
+ LQ
Sbjct: 1560 VNLQ 1563
Score = 49.7 bits (117), Expect = 5e-06
Identities = 76/343 (22%), Positives = 149/343 (43%), Gaps = 58/343 (16%)
Query: 123 LRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAA------LVEEVYFAQKE 176
L+ +++ ++K + ++ R+++ +LE + K+ +A + L + A K
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
Query: 177 RDEAV--MSRLQLAIEE-----------RDEAIARAKHMEMSLKVLENINPEENDMTLQE 223
RDEA+ + +LQ +++ R+E +A+AK E LK +E + LQE
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSME-----AEMIQLQE 1687
Query: 224 LLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQE 283
L A Q+ + D I + + + + +EE+ ++ +LE+E
Sbjct: 1688 ELAAAERAKR--QAQQERDELADEIANS--------SGKGALALEEKRRLEARIAQLEEE 1737
Query: 284 LHHVKEQNQTSANNMR---------HLTAENNQERALKAKLLSMQQARETAVQQYK-KLE 333
L +EQ T N R + + N ER+ K + +Q E ++ K KL+
Sbjct: 1738 LE--EEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQ 1795
Query: 334 EEIQTLRVYY-----SLHKSLSQ-EENLKDQFNYTLSTYEEALKNRENIVSITQQQNEEL 387
E T++ Y +L ++Q EE L ++ + ++ + + + + Q ++E
Sbjct: 1796 EMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDER 1855
Query: 388 AT------QLQQALTERANMELQLQHAREASQVANEKVQKLER 424
Q +A T ++ QL+ A E +Q AN +KL+R
Sbjct: 1856 RNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/194 (23%), Positives = 81/194 (41%), Gaps = 12/194 (6%)
Query: 252 KECKMRITAEEMSALIEERDAA---LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQE 308
+E +M EE+ + E++ AA L++ + L+ +L K Q Q L AE +
Sbjct: 843 QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEEL 902
Query: 309 RA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRV--------YYSLHKSLSQEENLKDQF 359
RA L AK +++ + ++ EE Q L+ L + L +EE+ + +
Sbjct: 903 RARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL 962
Query: 360 NYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
T E LK E I + QN +LA + + A L E S+ +
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLK 1022
Query: 420 QKLERLVDVLRKKV 433
K E ++ L +++
Sbjct: 1023 NKHEAMITDLEERL 1036
>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
Length = 284
Score = 64.3 bits (155), Expect = 2e-10
Identities = 72/281 (25%), Positives = 123/281 (43%), Gaps = 42/281 (14%)
Query: 118 KELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKER 177
+EL L+ K + +L K ++ + + KLEL EK+ + AAL + ++E
Sbjct: 41 EELTHLQKKLKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGD-VAALNRRIQLVEEEL 99
Query: 178 DEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIA 236
D A RL A+++ +EA A E +KV+EN +E M +QE+ ++ A
Sbjct: 100 DRA-QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEM--QLKEA----- 151
Query: 237 IQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSAN 296
K+ A DR Y+ K+ I E+ E + + KC LE+EL +V N
Sbjct: 152 --KHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNV-------TN 202
Query: 297 NMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLK 356
N++ S++ A E ++ K EEEI+ L L + E
Sbjct: 203 NLK-----------------SLEAASEKYSEKEDKYEEEIKL------LSDKLKEAETRA 239
Query: 357 DQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE 397
+ T++ E+ + + E ++ +++N L L Q L E
Sbjct: 240 EFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNE 280
Score = 37.0 bits (84), Expect = 0.036
Identities = 35/165 (21%), Positives = 72/165 (43%), Gaps = 22/165 (13%)
Query: 269 ERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQ 328
++ AA KCK++E+EL H++++ + + + + + + L Q+ E ++
Sbjct: 28 DKKAAEDKCKQVEEELTHLQKKLKGTEDELDKYSED----------LKDAQEKLELTEKK 77
Query: 329 YKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELA 388
E ++ +L++ + E D+ L+T AL+ E + +
Sbjct: 78 ASDAEGDVA------ALNRRIQLVEEELDRAQERLAT---ALQKLEEAEKAADESERGMK 128
Query: 389 TQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
+A+ + ME+Q +EA +A E +K E +V RK V
Sbjct: 129 VIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYE---EVARKLV 170
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 64.3 bits (155), Expect = 2e-10
Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)
Query: 72 DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
DD++ + E+ ++E R +D+ T+ +++E+ L K + + +L+
Sbjct: 991 DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 132 QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
+L KE+K E KLK KLE + +IA+ A + E ++ A+KE + +A ++RL
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 187 LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
I +++ A+ + + +E + L E+++ E E R D G ++ +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1156
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
D + T T +E+ A E+ L K E H V+E Q A + LT
Sbjct: 1157 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 304 ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
+ Q + KA +L + QA++ + KKLE ++Q L+ S
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 345 -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
+HK ++ E++ N +++ L++ + ++ +Q
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 384 NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
++T+L+Q ER +++ QL EA Q + L + +KK+
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Score = 62.0 bits (149), Expect = 1e-09
Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)
Query: 137 EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
E E+++ + + +L E ETE + K AL A K++ E + L+L AI+ R
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1640
Query: 193 DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
+EAI + + ++ +K LE+ +++ T +E + + + + + +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 247 RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
R K + + AEE+++ + R+A + +RLE + ++E+ + NM R
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 300 HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
T + Q A S Q E+A QQ ++ +E+++ LH+ E +K +F
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1812
Query: 360 NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
T++ E + E V + Q ++E + +
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 397 ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
E+ N ++ QL+ A E SQ N +KL+R +D
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Score = 52.8 bits (125), Expect = 6e-07
Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)
Query: 11 SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
S LE KS Q E+L E H + +L +I E ++ Q
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1095
Query: 68 SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
+ DDE +K +E +D+ + + + ++K+K L +EL+ L+T
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1153
Query: 126 -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
S Q+ AK ++E LK L+ + + EA++ E K A VEE+
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 174 QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
Q +R +A + + + +E+ + +A + K +E ++ L E
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 212 INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
E ND + +L N + + TG+ + G AI + + + +++ T E + ++
Sbjct: 1274 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 271 DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
+K ++LE+E + +++Q + N RH++ N Q K KL E
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 327 QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
+ K+ ++EI+ L + Y + + E K++ L L N+ +VS +++
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 386 ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
+ Q L E N+ + R+ ++ A EK K L L +
Sbjct: 1452 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Score = 49.3 bits (116), Expect = 7e-06
Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)
Query: 14 EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
EQE T + K+ + + + M +K + V E+T E E + N
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1223
Query: 74 ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
+ +E + D+ E Q + + K+K + ++EL + ++ +
Sbjct: 1224 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 133 KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
+L + + KL+ ++E L E E +A K+A+ A+L ++ Q+ E +L
Sbjct: 1277 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 187 LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
++ EER DE + +++E + L NI ++ LQ+ + + +
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1392
Query: 234 GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
G + + + E ++ EE+ AA K ++ + L +
Sbjct: 1393 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 294 SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
+N R L + E Q + + K +S + A E + + E+E + L + +L +
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 348 SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
+L +E L+ + E+ + +++++ V ++ L TQ+++ T+ +E +
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 405 LQHAREASQVANEKVQKLE 423
LQ +A +Q L+
Sbjct: 1555 LQATEDAKLRLEVNMQALK 1573
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
D + KTKE + + AE +E++ + L++ K L QE + + A MR A
Sbjct: 859 DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
QE L+ L M+ E + ++L+ E + + + L + L +EE + +
Sbjct: 917 KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 365 TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
T E +K E+ + + QN +L+ + ++ L ER N+ + + A+ +++ N+
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 420 QKLERLVDVLRKK 432
+ L L+K+
Sbjct: 1034 SMISELEVRLKKE 1046
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 64.3 bits (155), Expect = 2e-10
Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)
Query: 72 DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
DD++ + E+ ++E R +D+ T+ +++E+ L K + + +L+
Sbjct: 998 DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 132 QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
+L KE+K E KLK KLE + +IA+ A + E ++ A+KE + +A ++RL
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 187 LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
I +++ A+ + + +E + L E+++ E E R D G ++ +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1163
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
D + T T +E+ A E+ L K E H V+E Q A + LT
Sbjct: 1164 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 304 ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
+ Q + KA +L + QA++ + KKLE ++Q L+ S
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 345 -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
+HK ++ E++ N +++ L++ + ++ +Q
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 384 NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
++T+L+Q ER +++ QL EA Q + L + +KK+
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Score = 62.0 bits (149), Expect = 1e-09
Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)
Query: 137 EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
E E+++ + + +L E ETE + K AL A K++ E + L+L AI+ R
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1647
Query: 193 DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
+EAI + + ++ +K LE+ +++ T +E + + + + + +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 247 RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
R K + + AEE+++ + R+A + +RLE + ++E+ + NM R
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 300 HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
T + Q A S Q E+A QQ ++ +E+++ LH+ E +K +F
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1819
Query: 360 NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
T++ E + E V + Q ++E + +
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 397 ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
E+ N ++ QL+ A E SQ N +KL+R +D
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Score = 52.8 bits (125), Expect = 6e-07
Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)
Query: 11 SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
S LE KS Q E+L E H + +L +I E ++ Q
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1102
Query: 68 SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
+ DDE +K +E +D+ + + + ++K+K L +EL+ L+T
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1160
Query: 126 -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
S Q+ AK ++E LK L+ + + EA++ E K A VEE+
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 174 QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
Q +R +A + + + +E+ + +A + K +E ++ L E
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 212 INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
E ND + +L N + + TG+ + G AI + + + +++ T E + ++
Sbjct: 1281 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 271 DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
+K ++LE+E + +++Q + N RH++ N Q K KL E
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 327 QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
+ K+ ++EI+ L + Y + + E K++ L L N+ +VS +++
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 386 ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
+ Q L E N+ + R+ ++ A EK K L L +
Sbjct: 1459 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Score = 49.3 bits (116), Expect = 7e-06
Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)
Query: 14 EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
EQE T + K+ + + + M +K + V E+T E E + N
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1230
Query: 74 ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
+ +E + D+ E Q + + K+K + ++EL + ++ +
Sbjct: 1231 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 133 KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
+L + + KL+ ++E L E E +A K+A+ A+L ++ Q+ E +L
Sbjct: 1284 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 187 LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
++ EER DE + +++E + L NI ++ LQ+ + + +
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1399
Query: 234 GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
G + + + E ++ EE+ AA K ++ + L +
Sbjct: 1400 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 294 SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
+N R L + E Q + + K +S + A E + + E+E + L + +L +
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 348 SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
+L +E L+ + E+ + +++++ V ++ L TQ+++ T+ +E +
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 405 LQHAREASQVANEKVQKLE 423
LQ +A +Q L+
Sbjct: 1562 LQATEDAKLRLEVNMQALK 1580
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
D + KTKE + + AE +E++ + L++ K L QE + + A MR A
Sbjct: 866 DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
QE L+ L M+ E + ++L+ E + + + L + L +EE + +
Sbjct: 924 KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 365 TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
T E +K E+ + + QN +L+ + ++ L ER N+ + + A+ +++ N+
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 420 QKLERLVDVLRKK 432
+ L L+K+
Sbjct: 1041 SMISELEVRLKKE 1053
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 64.3 bits (155), Expect = 2e-10
Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)
Query: 72 DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
DD++ + E+ ++E R +D+ T+ +++E+ L K + + +L+
Sbjct: 998 DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 132 QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
+L KE+K E KLK KLE + +IA+ A + E ++ A+KE + +A ++RL
Sbjct: 1048 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1107
Query: 187 LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
I +++ A+ + + +E + L E+++ E E R D G ++ +
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1163
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
D + T T +E+ A E+ L K E H V+E Q A + LT
Sbjct: 1164 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Query: 304 ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
+ Q + KA +L + QA++ + KKLE ++Q L+ S
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 345 -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
+HK ++ E++ N +++ L++ + ++ +Q
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1337
Query: 384 NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
++T+L+Q ER +++ QL EA Q + L + +KK+
Sbjct: 1338 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Score = 62.0 bits (149), Expect = 1e-09
Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)
Query: 137 EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
E E+++ + + +L E ETE + K AL A K++ E + L+L AI+ R
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1647
Query: 193 DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
+EAI + + ++ +K LE+ +++ T +E + + + + + +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 247 RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
R K + + AEE+++ + R+A + +RLE + ++E+ + NM R
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 300 HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
T + Q A S Q E+A QQ ++ +E+++ LH+ E +K +F
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1819
Query: 360 NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
T++ E + E V + Q ++E + +
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 397 ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
E+ N ++ QL+ A E SQ N +KL+R +D
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915
Score = 52.8 bits (125), Expect = 6e-07
Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)
Query: 11 SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
S LE KS Q E+L E H + +L +I E ++ Q
Sbjct: 1044 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1102
Query: 68 SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
+ DDE +K +E +D+ + + + ++K+K L +EL+ L+T
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1160
Query: 126 -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
S Q+ AK ++E LK L+ + + EA++ E K A VEE+
Sbjct: 1161 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1220
Query: 174 QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
Q +R +A + + + +E+ + +A + K +E ++ L E
Sbjct: 1221 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1280
Query: 212 INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
E ND + +L N + + TG+ + G AI + + + +++ T E + ++
Sbjct: 1281 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 271 DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
+K ++LE+E + +++Q + N RH++ N Q K KL E
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 327 QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
+ K+ ++EI+ L + Y + + E K++ L L N+ +VS +++
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 386 ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
+ Q L E N+ + R+ ++ A EK K L L +
Sbjct: 1459 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Score = 49.3 bits (116), Expect = 7e-06
Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)
Query: 14 EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
EQE T + K+ + + + M +K + V E+T E E + N
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1230
Query: 74 ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
+ +E + D+ E Q + + K+K + ++EL + ++ +
Sbjct: 1231 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1283
Query: 133 KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
+L + + KL+ ++E L E E +A K+A+ A+L ++ Q+ E +L
Sbjct: 1284 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 187 LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
++ EER DE + +++E + L NI ++ LQ+ + + +
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1399
Query: 234 GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
G + + + E ++ EE+ AA K ++ + L +
Sbjct: 1400 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 294 SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
+N R L + E Q + + K +S + A E + + E+E + L + +L +
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 348 SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
+L +E L+ + E+ + +++++ V ++ L TQ+++ T+ +E +
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 405 LQHAREASQVANEKVQKLE 423
LQ +A +Q L+
Sbjct: 1562 LQATEDAKLRLEVNMQALK 1580
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
D + KTKE + + AE +E++ + L++ K L QE + + A MR A
Sbjct: 866 DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 923
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
QE L+ L M+ E + ++L+ E + + + L + L +EE + +
Sbjct: 924 KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 365 TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
T E +K E+ + + QN +L+ + ++ L ER N+ + + A+ +++ N+
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 420 QKLERLVDVLRKK 432
+ L L+K+
Sbjct: 1041 SMISELEVRLKKE 1053
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 64.3 bits (155), Expect = 2e-10
Identities = 90/410 (21%), Positives = 175/410 (42%), Gaps = 68/410 (16%)
Query: 72 DDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQ 131
DD++ + E+ ++E R +D+ T+ +++E+ L K + + +L+
Sbjct: 991 DDQNNKLSKER-KLLEERISDL---------TTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 132 QKLAKEDK---EQRKLKFKLELQEKETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQ 186
+L KE+K E KLK KLE + +IA+ A + E ++ A+KE + +A ++RL
Sbjct: 1041 VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLD 1100
Query: 187 LAIEERDEAIARAKHMEMSLKVL-ENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
I +++ A+ + + +E + L E+++ E E R D G ++ +
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR----DLGEELEALKTELE 1156
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELH--HVKEQNQTSANNMRHLTA 303
D + T T +E+ A E+ L K E H V+E Q A + LT
Sbjct: 1157 DTLDST------ATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Query: 304 ENNQERALKA------------------KLLSMQQARETAVQQYKKLEEEIQTLRVYYS- 344
+ Q + KA +L + QA++ + KKLE ++Q L+ S
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 345 -----------LHKSLSQEENLKDQFNYT----------LSTYEEALKNRENIVSITQQQ 383
+HK ++ E++ N +++ L++ + ++ +Q
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQ 1330
Query: 384 NEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
++T+L+Q ER +++ QL EA Q + L + +KK+
Sbjct: 1331 KLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Score = 62.0 bits (149), Expect = 1e-09
Identities = 74/336 (22%), Positives = 143/336 (42%), Gaps = 57/336 (16%)
Query: 137 EDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL----AIEER 192
E E+++ + + +L E ETE + K AL A K++ E + L+L AI+ R
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAA----AAKKKLEGDLKDLELQADSAIKGR 1640
Query: 193 DEAIARAKHMEMSLK----VLENINPEENDM--TLQELLNRINNADTGIAIQKNGAIIVD 246
+EAI + + ++ +K LE+ +++ T +E + + + + + +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 247 RIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM-------R 299
R K + + AEE+++ + R+A + +RLE + ++E+ + NM R
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 300 HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQF 359
T + Q A S Q E+A QQ ++ +E+++ LH+ E +K +F
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS-----KLHE---MEGAVKSKF 1812
Query: 360 NYTLSTYEEALKNRENIVS-----------------------ITQQQNEELATQLQQALT 396
T++ E + E V + Q ++E + +
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 397 ERAN-----MELQLQHAREASQVANEKVQKLERLVD 427
E+ N ++ QL+ A E SQ N +KL+R +D
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908
Score = 52.8 bits (125), Expect = 6e-07
Identities = 101/467 (21%), Positives = 191/467 (40%), Gaps = 55/467 (11%)
Query: 11 SYLEQETTGINKSTQPDEQLTMNSE---KSMHRKSTELVNEITCENTEWPGQRSTNFQII 67
S LE KS Q E+L E H + +L +I E ++ Q
Sbjct: 1037 SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA-ELKMQLAKKEEELQAA 1095
Query: 68 SSYPDDESVYCTT--EKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRT 125
+ DDE +K +E +D+ + + + ++K+K L +EL+ L+T
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD--LGEELEALKT 1153
Query: 126 -------SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE---KTAALVEEV--YFA 173
S Q+ AK ++E LK L+ + + EA++ E K A VEE+
Sbjct: 1154 ELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLE 1213
Query: 174 QKERDEAVMSRLQLAIEERDEAIA---------------RAKHMEMSLKVL-------EN 211
Q +R +A + + + +E+ + +A + K +E ++ L E
Sbjct: 1214 QFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGER 1273
Query: 212 INPEENDMTLQELLNRINNADTGIAIQKNG-AIIVDRIYKTKECKMRITAEEMSALIEER 270
E ND + +L N + + TG+ + G AI + + + +++ T E + ++
Sbjct: 1274 ARAELNDK-VHKLQNEVESV-TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 271 DAALSKCKRLEQELHHVKEQ----NQTSANNMRHLTAENNQERALKAKLLSMQQARETAV 326
+K ++LE+E + +++Q + N RH++ N Q K KL E
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 327 QQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNE 385
+ K+ ++EI+ L + Y + + E K++ L L N+ +VS +++
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 386 ELATQLQQALTERANMELQLQHAREASQV-ANEKVQKLERLVDVLRK 431
+ Q L E N+ + R+ ++ A EK K L L +
Sbjct: 1452 ----KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Score = 49.3 bits (116), Expect = 7e-06
Identities = 83/439 (18%), Positives = 178/439 (40%), Gaps = 67/439 (15%)
Query: 14 EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPDD 73
EQE T + K+ + + + M +K + V E+T E E + N
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT-EQLEQFKRAKANLD-------- 1223
Query: 74 ESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSD-KEKTIAFLLKELDILRTSNKKLQQ 132
+ +E + D+ E Q + + K+K + ++EL + ++ +
Sbjct: 1224 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA 1276
Query: 133 KLAKEDKEQRKLKFKLE-----LQEKETEA-KIAEKTAALVEEVYFAQKERDEAVMSRLQ 186
+L + + KL+ ++E L E E +A K+A+ A+L ++ Q+ E +L
Sbjct: 1277 EL---NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 187 LAI------EER-------DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADT 233
++ EER DE + +++E + L NI ++ LQ+ + + +
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL-NIQLSDSKKKLQDFASTVEALEE 1392
Query: 234 GIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQT 293
G + + + E ++ EE+ AA K ++ + L +
Sbjct: 1393 G------------------KKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 294 SANNMRHLTA--ENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHK 347
+N R L + E Q + + K +S + A E + + E+E + L + +L +
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 348 SLSQEENLKDQFNYTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQ 404
+L +E L+ + E+ + +++++ V ++ L TQ+++ T+ +E +
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 405 LQHAREASQVANEKVQKLE 423
LQ +A +Q L+
Sbjct: 1555 LQATEDAKLRLEVNMQALK 1573
Score = 44.7 bits (104), Expect = 2e-04
Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 11/193 (5%)
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
D + KTKE + + AE +E++ + L++ K L QE + + A MR A
Sbjct: 859 DELQKTKERQQK--AENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAK 916
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTL-RVYYSLHKSLSQEENLKDQFNYTLS 364
QE L+ L M+ E + ++L+ E + + + L + L +EE + +
Sbjct: 917 KQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 365 TYEEALKNRENIVSITQQQNEELATQLQQALTER-----ANMELQLQHAREASQVANEKV 419
T E +K E+ + + QN +L+ + ++ L ER N+ + + A+ +++ N+
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKE-RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 420 QKLERLVDVLRKK 432
+ L L+K+
Sbjct: 1034 SMISELEVRLKKE 1046
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 64.3 bits (155), Expect = 2e-10
Identities = 75/301 (24%), Positives = 146/301 (48%), Gaps = 32/301 (10%)
Query: 119 ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERD 178
ELD++ ++K + L E +++++ +LE+ E + EK V+ KE+
Sbjct: 2384 ELDVVTIRSEK--ENLTNELQKEQERISELEIINSSFENILQEKEQEKVQ-----MKEKS 2436
Query: 179 EAVMSRLQLAIEERDEAIARAKHMEMSLKVLE-NINPEENDMTLQ--ELLNRINNADTG- 234
M LQ ++E +E +A + + + K E N++ + + L+ +LL ++ A
Sbjct: 2437 STAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNY 2496
Query: 235 IAIQKNGAIIVDRIYKTKECKMRITAEEMSAL---IEERDAALSKCKRLEQELHHVKEQN 291
I +Q + ++ + K+ K+ EE+S L I++++ +SK ++E E KEQN
Sbjct: 2497 IVLQSSVNGLIQEVEDGKQ-KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQN 2555
Query: 292 QTSANNMRHLTAENNQE-RALKAKLLSMQQARETAVQQYKKLEEEIQTLRV-----YYSL 345
+R+LT E Q+ + L++K S+Q E YK LE E++ ++ +
Sbjct: 2556 L----ELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611
Query: 346 HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL 405
+K ++E L+ + +E A K E ++ ++N LA +LQ L E + + QL
Sbjct: 2612 NKMTAKETELQREM------HEMAQKTAELQEELSGEKN-RLAGELQLLLEEIKSSKDQL 2664
Query: 406 Q 406
+
Sbjct: 2665 K 2665
Score = 61.2 bits (147), Expect = 2e-09
Identities = 66/340 (19%), Positives = 164/340 (48%), Gaps = 35/340 (10%)
Query: 120 LDILRTSNKKLQQKLAKEDKEQRKLKFK----------LELQEKET-----EAK-----I 159
+++L+T K+L +++A +Q K K LEL++ + EAK +
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499
Query: 160 AEKTAALVEEVYFAQK--ERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN 217
L++EV ++ E+ + +SRL+ I+++++ +++ +E ++ + N E
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559
Query: 218 DMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKC 277
++T+ EL +I + A ++ ++ YK E ++ +T + + +E+ + +K
Sbjct: 2560 NLTV-ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE 2618
Query: 278 KRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQ 337
L++E+H E Q +A L+ E N+ L +L + + +++ Q K+L E
Sbjct: 2619 TELQREMH---EMAQKTAELQEELSGEKNR---LAGELQLLLEEIKSSKDQLKELTLENS 2672
Query: 338 TLRVYYS-LHK-SLSQEENLKDQF-NYTLSTYEEALKNRENIVSITQQQNEELATQLQQA 394
L+ +HK + +E ++++ Y L +E K++ ++ +Q E+ T ++
Sbjct: 2673 ELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2732
Query: 395 LTER---ANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
++ ++ +L++ + + + N ++ ++++ L+K
Sbjct: 2733 TSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKK 2772
Score = 53.1 bits (126), Expect = 5e-07
Identities = 93/454 (20%), Positives = 176/454 (38%), Gaps = 59/454 (12%)
Query: 6 KDITHSYL--EQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTN 63
+D + SY EQE T ++ST + NS + S L++++ +N E + N
Sbjct: 239 RDFSASYFSGEQEVTP-SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQEL--RNKIN 295
Query: 64 FQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDIL 123
+ ++ + K+ ++ + E + +V + E + + D
Sbjct: 296 ELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE--LVRTTAQYDQA 353
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
T L+QKL K ++ + E E KI EK EE+ Q+
Sbjct: 354 STKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQE 413
Query: 184 RLQLAIEERDEAIARAKHMEMSLKV-LENINPEENDM--TLQELLNRINNADTGIAIQKN 240
+Q+ E + +AK+M L+ L+ + + + L+E ++ A+ +
Sbjct: 414 CIQMKARLTQE-LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQ- 471
Query: 241 GAIIVDRIYKTKECKMRITAEEM----SALIEERDAALSKCKRLEQELHHVKEQNQTSAN 296
KE ++R + EEM + L + + LE EL ++K+ S N
Sbjct: 472 ----------IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQN 521
Query: 297 NMRHLTAENNQERA--------------------LKAKLLSMQQARETAVQQYKKLEEEI 336
+ A+N + LK + +++ R+ + KK E I
Sbjct: 522 FAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHI 581
Query: 337 QTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALT 396
+ L L K+ + + L YEE LK + + S + +NE+L TQ++ +
Sbjct: 582 EQLND--KLSKTEKESKALLSALELKKKEYEE-LKEEKTLFSCWKSENEKLLTQME---S 635
Query: 397 ERANMELQLQHAREA-------SQVANEKVQKLE 423
E+ N++ ++ H S NE+V+ LE
Sbjct: 636 EKENLQSKINHLETCLKTQQIKSHEYNERVRTLE 669
Score = 49.3 bits (116), Expect = 7e-06
Identities = 68/325 (20%), Positives = 145/325 (44%), Gaps = 39/325 (12%)
Query: 118 KELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKER 177
+E+ LR +KL+ ++ ++K+Q + KL+ +E+E ++ + +K L E+ ++ E
Sbjct: 2112 EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS-LKDKVENLERELQMSE-EN 2169
Query: 178 DEAVMSRLQLAIEERDEAIARAKHMEMSLKVLE----NINPEENDMT--LQELLNRINNA 231
E V+ + + E + + + M SLKV E + E+ ++T +QE +++
Sbjct: 2170 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSA-------LIEERDAALSKCKRLEQEL 284
D ++ K+ + + ++ +++I E +A L E +A + C +QE+
Sbjct: 2230 DKLLSSFKS------LLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCG--DQEI 2281
Query: 285 HHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS 344
EQ+ H N L+A+L + ++ + +QQ K+ E L+
Sbjct: 2282 MKATEQSLDPPIEEEHQL--RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLK---- 2335
Query: 345 LHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQ 404
+ ENL+ + + E A EN ++ + E L +++ +EL
Sbjct: 2336 -----GRVENLERELEIARTNQEHAALEAEN----SKGEVETLKAKIEGMTQSLRGLELD 2386
Query: 405 LQHAR-EASQVANEKVQKLERLVDV 428
+ R E + NE ++ ER+ ++
Sbjct: 2387 VVTIRSEKENLTNELQKEQERISEL 2411
Score = 48.1 bits (113), Expect = 2e-05
Identities = 107/489 (21%), Positives = 203/489 (41%), Gaps = 61/489 (12%)
Query: 1 MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSE-----KSMHRKSTELVN------EI 49
+EN +++ S QE ++ E T+ ++ +S+ +LV +
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2215
Query: 50 TCENTEWPGQRSTNFQIISSYP------DDESVYCTTEKYNVMEHRHNDMHYECMTPCQV 103
T + E GQ S +++SS+ + + E +E N + +
Sbjct: 2216 TKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAAL 2275
Query: 104 TSDSD----KEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKI 159
D + E+++ ++E LR S +KL+ +L ++K+Q L +L+E E A +
Sbjct: 2276 CGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQ--LCVLQQLKESEHHADL 2333
Query: 160 AE-KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLE----NINP 214
+ + L E+ A+ ++ A + + + E + A+ + M SL+ LE I
Sbjct: 2334 LKGRVENLERELEIARTNQEHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRS 2392
Query: 215 EENDMT--LQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRI-TAEEMSAL----I 267
E+ ++T LQ+ RI+ + + +N I+ ++ + + K + TA EM +
Sbjct: 2393 EKENLTNELQKEQERISELEIINSSFEN--ILQEKEQEKVQMKEKSSTAMEMLQTQLKEL 2450
Query: 268 EERDAALSKCKRLEQELHHVKEQNQTS---------ANNMRHLTAENNQERALKAKLLSM 318
ER AAL +QE KEQN +S A ++ L N L++ + +
Sbjct: 2451 NERVAALHN----DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGL 2506
Query: 319 QQARETAVQQYKKLEEEIQTLRVYYS----LHKSLSQ---EENLKDQFNYTLSTYEEALK 371
Q E Q+ +K +EEI L+ L LSQ E L + N L L+
Sbjct: 2507 IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELE 2566
Query: 372 NRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
+ + + Q +N L L+ + N+E +L+ + EKV K+ L++
Sbjct: 2567 QK---IQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623
Query: 432 KVGTGTMRT 440
++ +T
Sbjct: 2624 EMHEMAQKT 2632
Score = 43.5 bits (101), Expect = 4e-04
Identities = 58/297 (19%), Positives = 121/297 (40%), Gaps = 43/297 (14%)
Query: 128 KKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL 187
++L KL+K +KE + L LEL++KE E EKT ++ K +E ++++++
Sbjct: 582 EQLNDKLSKTEKESKALLSALELKKKEYEELKEEKT------LFSCWKSENEKLLTQME- 634
Query: 188 AIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDR 247
E++ ++ H+E LK + + E N+ ++R +N ++ +
Sbjct: 635 --SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDR-----------ENLSVEIRN 681
Query: 248 IYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE-NN 306
++ + K + A +E L+Q+ +++Q NM T++
Sbjct: 682 LHNVLDSKSVEVETQKLAYME-----------LQQKAEFSDQKHQKEIENMCLKTSQLTG 730
Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
Q L+ KL + + Y+ L E ++LR L KS + +L +
Sbjct: 731 QVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLR---DLLKSKDASLVTNEDHQRSLLAF 787
Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLE 423
++ + +I +Q +ER+ L+ + + S + +V LE
Sbjct: 788 DQQPAMHHSFANIIGEQG--------SMPSERSECRLEADQSPKNSAILQNRVDSLE 836
Score = 43.1 bits (100), Expect = 5e-04
Identities = 63/362 (17%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 80 TEKYNVME-HRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKED 138
TE+ + E + N + + + Q+ S+ T++ KE+ + + NK+ ++L +E+
Sbjct: 922 TEQAEIQELKKSNHLLEDSLKELQLLSE-----TLSLEKKEMSSIISLNKREIEELTQEN 976
Query: 139 KEQRKLKFKLE------LQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQL---AI 189
+++ L +Q+ E+ A ++ + E+ K+ ++ R + A
Sbjct: 977 GTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAY 1036
Query: 190 EERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIY 249
E+ + A+ L+ L N E + N + A + +
Sbjct: 1037 EDLSQKYKAAQEKNSKLECLLN----ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFA 1092
Query: 250 KTKECKMRITAEEM-----SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + + + E + S + + ++ + S+ L+QE+ +KE+ + L E
Sbjct: 1093 EERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQE 1152
Query: 305 NNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLS 364
N Q + Q ++ K E E + + + L +E D +N L
Sbjct: 1153 NEQLMKVMKTKHECQNLESEPIRNSVK-ERESERNQCNFKPQMDLEVKEISLDSYNAQLV 1211
Query: 365 TYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLER 424
E L+N+E + ++++ E L +LQ + LQ ++E S + + ++ E+
Sbjct: 1212 QLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEK 1271
Query: 425 LV 426
+
Sbjct: 1272 YI 1273
Score = 38.9 bits (89), Expect = 0.009
Identities = 68/325 (20%), Positives = 139/325 (42%), Gaps = 41/325 (12%)
Query: 119 ELDILRTSNKKLQQKLAKEDK---------EQRKLKFKLELQEKETEAKIAEKTAALVEE 169
+L + TSN+ L+ ED+ E ++L KL LQE + KI + +E+
Sbjct: 1773 QLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKI--EACIELEK 1830
Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRIN 229
+ K+ + + +L+ + E + R ++ E +N + L+ ++ +
Sbjct: 1831 IVGELKKENSDLSEKLEYFSCDHQELLQR-------VETSEGLNSD-----LEMHADKSS 1878
Query: 230 NADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMS----ALIEERDAALSKCKRLEQELH 285
D G + K +R + RI +E+ S AL E D + + ++L E
Sbjct: 1879 REDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKD 1938
Query: 286 HVKEQNQTSA--NNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYY 343
+ +Q + +T+E NQ L+ +L +M + Q +K++E+ Q L +
Sbjct: 1939 NENKQKVIVCLEEELSVVTSERNQ---LRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 344 S--LHKSLSQEENLKD--QFNYTLST-YEEALKNRENIVSITQQQNEELATQLQQALTER 398
S LH E +K+ + TLS+ E LK++ ++ Q++ + L Q +
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHL----QEKLQSLEKDSQALSLTK 2051
Query: 399 ANMELQLQHAREASQVANEKVQKLE 423
+E Q+ + ++ ++ + L+
Sbjct: 2052 CELENQIAQLNKEKELLVKESESLQ 2076
Score = 32.0 bits (71), Expect = 1.2
Identities = 26/141 (18%), Positives = 67/141 (47%), Gaps = 6/141 (4%)
Query: 291 NQTSANNMRHLTAENNQER----ALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLH 346
N +S + + L A+N + R L+ +L ++ + V ++++L+ +++ +V L
Sbjct: 273 NSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV--ELI 330
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
+ +D+ T + Y++A + ++ E+L+ Q Q A + R ++E +++
Sbjct: 331 EKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK 390
Query: 407 HAREASQVANEKVQKLERLVD 427
+ Q + Q+ + +D
Sbjct: 391 EKEKEFQEELSRQQRSFQTLD 411
Score = 30.8 bits (68), Expect = 2.6
Identities = 43/202 (21%), Positives = 82/202 (40%), Gaps = 32/202 (15%)
Query: 13 LEQETTGINKSTQPDEQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSYPD 72
L++E +G + QL + KS S + + E+T EN+E ++S +
Sbjct: 2635 LQEELSGEKNRLAGELQLLLEEIKS----SKDQLKELTLENSEL--KKSLDCMHKDQVEK 2688
Query: 73 DESVYCTTEKYNVMEHRHNDMH----------YECMTPCQVTSDSDKEKTIAFLLKELDI 122
+ V +Y + H H YE + KE+ ++ E+D+
Sbjct: 2689 EGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDL 2748
Query: 123 LRTSNKKLQQKLAKEDKEQRKLK------------FKLELQEKETEAKIAEKTAALVEEV 170
L++S ++L L + +LK K E + + + K+ K+ +EE
Sbjct: 2749 LKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE- 2807
Query: 171 YFAQKERDEAVMSRLQLAIEER 192
+KE + +S+LQ A E++
Sbjct: 2808 ---EKEILQKELSQLQAAQEKQ 2826
>gi|122937396 coiled-coil domain containing 150 [Homo sapiens]
Length = 1101
Score = 64.3 bits (155), Expect = 2e-10
Identities = 68/320 (21%), Positives = 144/320 (45%), Gaps = 25/320 (7%)
Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAI 189
L+++LAK + L L+ E+E + +A++ A+L E+ + +++
Sbjct: 495 LEKELAKNKVDINTLTHNLQTLEEENK-HLADQMASL--ELQQVTSDYHGLAQQKVEKIT 551
Query: 190 EERDEAIARAKHMEMSLKVLENINPEENDMTLQ-ELLNRINNADTGIAIQKNGAIIVDRI 248
E +++ +++ +K LE D +LQ + L ++N Q N + R+
Sbjct: 552 ESKNKLAYENGKLQIKVKQLEEQVQSFTDTSLQNDHLRKMNKYLQTKYAQANSELSAKRV 611
Query: 249 Y------KTKECK--MRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
+ KE K + + EE+S ++ R+AAL + ++L+++L V+++ N +
Sbjct: 612 HLQQADAHLKEVKSILERSKEELSRTVKCRNAALKESQKLKEDLEAVEDRENKKVGNFQR 671
Query: 301 LTAENNQERALKAKLL--------SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE 352
AE ++ +L MQ A E + + + EI L+ L++ Q+
Sbjct: 672 QLAEAKEDNCKVTIMLENVLASHSKMQGALEKVQIELGRRDSEIAGLKKERDLNQQRVQK 731
Query: 353 -ENLKDQFNYTLSTYEE----ALKNRENIVSITQQQNEELATQLQQALTERANMELQLQH 407
E DQ+ + E+ +++ + + + ++ N +LA L+QAL +++ +L H
Sbjct: 732 LEAEVDQWQARMLVMEDQHNSEIESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDH 791
Query: 408 AREASQVANEKVQKLERLVD 427
+E + + Q LE D
Sbjct: 792 IQEQLESKELERQNLETFKD 811
Score = 49.7 bits (117), Expect = 5e-06
Identities = 71/327 (21%), Positives = 133/327 (40%), Gaps = 56/327 (17%)
Query: 106 DSDKEKTIAFLLKEL------DILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKI 159
D D +K I+ + E DIL + + L ++ + + + LK + + E +
Sbjct: 70 DLDSQKVISPIQNEAICAGKTDILWKNCEFLVNRMCRLESLMQSLKMNIFRLQTEKDLN- 128
Query: 160 AEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME-MSLKVLENINPEEND 218
+KTA L + + AI+E + H+E M+L+ EE D
Sbjct: 129 PQKTAFLKDRLN----------------AIQEEHSKDLKLLHLEVMNLRQQLRAVKEEED 172
Query: 219 MTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCK 278
E+ +KN AII + + KT + KM + +E+ +
Sbjct: 173 KAQDEVQRLTATLKIASQTKKNAAIIEEEL-KTTKRKMNLKIQELR-------------R 218
Query: 279 RLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQT 338
+L QE +++E + SA+ A+ K+ M E +Q L++
Sbjct: 219 QLAQE-KYLRESLEKSAS-------------AMLLKIQEMGSTVEVERKQVHILQQNCIA 264
Query: 339 LR-VYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE 397
LR S + L+QE+ K++ S + L +R++++S ++N+ L + E
Sbjct: 265 LRDSIQSAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEE 324
Query: 398 RANME---LQLQHAREASQVANEKVQK 421
A + + L A E +QV N+++ K
Sbjct: 325 NAYLRSEIMSLHEASEKAQVLNDQLTK 351
Score = 48.1 bits (113), Expect = 2e-05
Identities = 73/362 (20%), Positives = 151/362 (41%), Gaps = 81/362 (22%)
Query: 120 LDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFA------ 173
L I + Q+K +E E+ L++QE + ++ K ++++ A
Sbjct: 211 LKIQELRRQLAQEKYLRESLEKSASAMLLKIQEMGSTVEVERKQVHILQQNCIALRDSIQ 270
Query: 174 -----------QKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ 222
+KE E S+L+ + RD+ I++ +L++ N EEN
Sbjct: 271 SAQELLAQEQKKKEELEIATSQLKSDLTSRDDLISKLVEENKNLQISFNKEHEENAYLRS 330
Query: 223 ELLNRINNADTGIAI-------------------QKNGAIIVDR--IYKTKECKMRITAE 261
E+++ ++ + + II D I + ++ M T +
Sbjct: 331 EIMSLHEASEKAQVLNDQLTKKCSELSCMLQTVTMEKARIIADHQAILQVEQKMMTQTFQ 390
Query: 262 EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ----------ERAL 311
E + L++ A+++ EL V+ + ++ HL E+NQ A+
Sbjct: 391 EQNLLLDAAHASIT------NELQTVQNEKTQLQAHLDHLILEHNQCIQKAQDAEKRTAV 444
Query: 312 KAKLLSMQQAR-----ETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
+ +LL AR E ++Q+ K L EE + + + +++E ++++ N
Sbjct: 445 QKELLESTIARLRGELEASMQEKKSLLEE----KERFQREVNKTEKEIVQERCNLE---- 496
Query: 367 EEALKNRENIVSIT------QQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQ 420
+E KN+ +I ++T +++N+ LA Q+ A++ELQ Q + +A +KV+
Sbjct: 497 KELAKNKVDINTLTHNLQTLEEENKHLADQM-------ASLELQ-QVTSDYHGLAQQKVE 548
Query: 421 KL 422
K+
Sbjct: 549 KI 550
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/204 (20%), Positives = 92/204 (45%), Gaps = 17/204 (8%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I L K+ R + KK+ Q+ E K+ ++ T ++ +K A L E++
Sbjct: 828 IEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAEL-EKILE 886
Query: 173 AQKERDEAVMSRLQLAIEERD---EAIARAKHMEMSLKVLENINPE------ENDMTLQE 223
+ KE+ + ++++L + + + I R K +E LK +E I + E +++Q
Sbjct: 887 SNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQMELIKDQYQKKNYEQSLSIQR 946
Query: 224 LLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQE 283
+ + N + + D + K+ ++ + AE + R ++C+ LE+
Sbjct: 947 FVCEMTNLQKEMQMLAKSQY--DASVRNKQQELHLEAER-----KIRQELENRCQELEET 999
Query: 284 LHHVKEQNQTSANNMRHLTAENNQ 307
+ H+K+ + + N ++ + E+ Q
Sbjct: 1000 VRHLKKCKEATENTLKEASVESEQ 1023
Score = 44.3 bits (103), Expect = 2e-04
Identities = 70/358 (19%), Positives = 141/358 (39%), Gaps = 67/358 (18%)
Query: 123 LRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVM 182
L+ S K + A ED+E +K+ Q + EAK ++ E A + + +
Sbjct: 645 LKESQKLKEDLEAVEDRENKKVG---NFQRQLAEAKEDNCKVTIMLENVLASHSKMQGAL 701
Query: 183 SRLQLAIEERDEAIARAK-HMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNG 241
++Q+ + RD IA K +++ + ++ + E + + L+ + ++QK
Sbjct: 702 EKVQIELGRRDSEIAGLKKERDLNQQRVQKLEAEVDQWQARMLVMEDQHNSEIESLQK-- 759
Query: 242 AIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + E+ L + AL L+ +L H++EQ ++ ++L
Sbjct: 760 -------------ALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESKELERQNL 806
Query: 302 -------TAENNQERALKAKLLS-----MQQARETA-------VQQYKKLEEE-----IQ 337
T E+ E L A+ + Q RET V + KK +E ++
Sbjct: 807 ETFKDRMTEESKVEAELHAERIEALRKQFQTERETTKKVAQREVAELKKALDEANFRSVE 866
Query: 338 TLRVYYSLHKSL--------SQEENLKDQFNY----------------TLSTYEEALKNR 373
R L + L S +E +K+Q + E+ LK
Sbjct: 867 VSRTNRELRQKLAELEKILESNKEKIKNQKTQIKLHLSAKANNAQNIERMKQIEKELKQM 926
Query: 374 ENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
E I Q++N E + +Q+ + E N++ ++Q ++ A+ + ++ E ++ RK
Sbjct: 927 ELIKDQYQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEAERK 984
Score = 42.4 bits (98), Expect = 9e-04
Identities = 71/324 (21%), Positives = 125/324 (38%), Gaps = 77/324 (23%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I L K L + R N+KL L + + L+ KL+ +++ E+K
Sbjct: 754 IESLQKALGVAREDNRKLAMSLEQALQTNNHLQTKLDHIQEQLESK-------------- 799
Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
+ ER + ++ E + EA A+ +E K + T +E
Sbjct: 800 -ELERQNLETFKDRMTEESKVEAELHAERIEALRKQFQ---------TERE--------- 840
Query: 233 TGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEE--RDAALSKCKR-LEQELHHVKE 289
TK+ R AE AL E R +S+ R L Q+L +++
Sbjct: 841 -----------------TTKKVAQREVAELKKALDEANFRSVEVSRTNRELRQKLAELEK 883
Query: 290 QNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSL 349
+++ ++ NQ+ +K L A+ Q +++++ + K L
Sbjct: 884 ILESNKEKIK------NQKTQIKLHL----SAKANNAQNIERMKQ----------IEKEL 923
Query: 350 SQEENLKDQFNYTLSTYEEALKNRENIVSIT--QQQNEELATQLQQALTERANMELQLQH 407
Q E +KDQ Y YE++L + + +T Q++ + LA A EL L+
Sbjct: 924 KQMELIKDQ--YQKKNYEQSLSIQRFVCEMTNLQKEMQMLAKSQYDASVRNKQQELHLEA 981
Query: 408 AREASQVANEKVQKLERLVDVLRK 431
R+ Q + Q+LE V L+K
Sbjct: 982 ERKIRQELENRCQELEETVRHLKK 1005
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 63.9 bits (154), Expect = 3e-10
Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)
Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
++ + K Q+++ K++ EQ + K++LQE +E ++ I ++TA ++
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
+ A++ +++ S+L + + + R M++ + +N EE+ M +Q++L +
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578
Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
I + IA Q + +++ + ++K K + + +L ERD SK E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634
Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
+EL ++ N ++ L A N++ A +L MQQ+ + + LEE++Q
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690
Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
+ + + + + L DQ N L + + L+ +++Q N+++ Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)
Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
+D+L+ + +Q L K K Q + K KL KE A ++ L +E+
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363
Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
+KER V++R++ +R + + ++ + + ++ M Q++ ++ A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418
Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
Q+NG + +++ + ++ ++ + L+ E K +L+QE
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475
Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
K Q + L AE E ++ + + A++ ++ E E+Q+L +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533
Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
L +L ++ L+ + + + ++ + E++ Q +QNE L Q+QQ ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593
Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
A E +V EK +++++ D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Score = 44.7 bits (104), Expect = 2e-04
Identities = 88/414 (21%), Positives = 173/414 (41%), Gaps = 48/414 (11%)
Query: 28 EQLTMNSEKSMHRKSTELVNEITCENTEWPGQ----RSTNFQIISSYPDDESVY-CTTEK 82
E + E + K T+L+ ++ EN + Q + N+Q SS+P E + +E+
Sbjct: 923 EAMLKERESDLSSK-TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 981
Query: 83 YNVMEHRHNDMHY--ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKE 140
+ N++ + + + ++ +EK + ++ L ++ K LQ K+ K KE
Sbjct: 982 EKEISGLWNELDSLKDAVEHQRKKNNDLREKN----WEAMEALASTEKMLQDKVNKTSKE 1037
Query: 141 QRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAK 200
+++ +EL+ KE K+ K + Y E ++ E +A
Sbjct: 1038 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE----------KKAKECMAGTS 1087
Query: 201 HMEMSLKVLENINPEENDM-TLQEL---LNRINNADTGIAIQKNGAIIVDRIYKTKECKM 256
E +KVLE+ E ++M TL +L + A+T +QK + R + +E K
Sbjct: 1088 GSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK-----LQRSVEQEENKW 1141
Query: 257 RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMR---HLTAENNQERALKA 313
++ +E I++ ++ + EQEL ++ +N+ N R HL E E+A
Sbjct: 1142 KVKVDESHKTIKQMQSSFTSS---EQELERLRSENKDIENLRREREHL--EMELEKAEME 1196
Query: 314 KLLSMQQARETAVQQYKKL----EEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEA 369
+ + + RE Q + L E+ + +V LHK+ E ++ + +
Sbjct: 1197 RSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI-VKAAGDTTV 1255
Query: 370 LKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLE 423
++N + + E ++ L Q +T+ ++ LQ + E Q LE
Sbjct: 1256 IENSDVSPETESSEKETMSVSLNQTVTQ---LQQLLQAVNQQLTKEKEHYQVLE 1306
Score = 40.0 bits (92), Expect = 0.004
Identities = 78/371 (21%), Positives = 152/371 (40%), Gaps = 80/371 (21%)
Query: 85 VMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLK-----------ELDILRTSNKKLQQK 133
V E + D+ E M C + +K KT+ LL+ EL+ +RT N L +
Sbjct: 721 VSEQPNKDV-VEQMEKC-IQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTK- 777
Query: 134 LAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERD 193
E+Q+ + + A+LVEE+ E+D + S +L E
Sbjct: 778 ---------------EVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
Query: 194 EAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKE 253
+ + K +++S+ +QEL N + + + K + + KE
Sbjct: 823 KVANKEKTVQLSI-----------TSKVQELQNLLKGKEEQMNTMK-------AVLEEKE 864
Query: 254 CKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKA 313
+ T + + L EE ++ + + + Q H++KE +SA+ L ++
Sbjct: 865 KDLANTGKWLQDLQEENESLKAHVQEVAQ--HNLKE--ASSASQFEELEIVLKEKENELK 920
Query: 314 KLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY----TLSTYEEA 369
+L +M + RE+ + +L +++Q + SQ E LK Q NY + +EE
Sbjct: 921 RLEAMLKERESDLSSKTQLLQDVQDENKLFK-----SQIEQLKQQ-NYQQASSFPPHEEL 974
Query: 370 LK-----------------NRENIVSITQQQNEELATQLQQALTERANMELQLQHAREAS 412
LK + ++ V +++N +L + +A+ A+ E LQ + +
Sbjct: 975 LKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD--KVN 1032
Query: 413 QVANEKVQKLE 423
+ + E+ Q++E
Sbjct: 1033 KTSKERQQQVE 1043
Score = 38.5 bits (88), Expect = 0.012
Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)
Query: 84 NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
+V E + + + + QV +SD K ++ + + + + +K+ Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169
Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
K + Q+K+ E +R EA L L E + E+ + K
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212
Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
+ EN+ +E + + ++NAD+ + K I V+ I K+ K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272
Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
++ +A ++ +D LS + E + +KE Q+ ++ LT +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332
Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
Q + L ++++ + K+L +E+ T + +S +KD+ + T
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383
Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
E+ +N + ++ Q+ +++ + QQ R ME ++ H ++ + + + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433
Score = 37.0 bits (84), Expect = 0.036
Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)
Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
E D+ A K + L + + E+ + + +LL +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321
Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
+ + ++ ++ +A+ E+ A +CK+L QE+ KE++ M+
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
+E + Q + Q+ ++++ + Q +R + ++EN L+D +
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435
Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
T + E N + +Q L +L + + E+Q ++A +A+ ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492
Query: 422 LER 424
ER
Sbjct: 493 AER 495
Score = 32.3 bits (72), Expect = 0.88
Identities = 73/379 (19%), Positives = 158/379 (41%), Gaps = 60/379 (15%)
Query: 109 KEKTIAFLLKELDILRTSNKK--LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAAL 166
K K++ LL E ++L+ +NK+ +Q + + +E + L E Q +A + EK L
Sbjct: 809 KIKSVEELL-EAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 867
Query: 167 VEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQE 223
+ Q +E +E++ + +Q +A EA + ++ E+ + + E +EN++ E
Sbjct: 868 ANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KENELKRLE 923
Query: 224 LLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSALIEERDA 272
+ + +D +Q + +I + K+ + + EE+ +I ER+
Sbjct: 924 AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 983
Query: 273 ALS----KCKRLEQELHHV-KEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQ 327
+S + L+ + H K+ N N + A + E+ L+ K+ + R+ V+
Sbjct: 984 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVE 1043
Query: 328 QYK-KLEEEIQTLRVYYSLHKSLSQ---------------------------EENLK--D 357
+ + +E ++ L S+ +LS E LK D
Sbjct: 1044 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1103
Query: 358 QFNYTLST----YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQ 413
+ + L Y+ L E I+ Q+ E+ + + + E Q+Q + +S+
Sbjct: 1104 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1163
Query: 414 VANEKVQKLERLVDVLRKK 432
E+++ + ++ LR++
Sbjct: 1164 QELERLRSENKDIENLRRE 1182
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 63.9 bits (154), Expect = 3e-10
Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)
Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
++ + K Q+++ K++ EQ + K++LQE +E ++ I ++TA ++
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
+ A++ +++ S+L + + + R M++ + +N EE+ M +Q++L +
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578
Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
I + IA Q + +++ + ++K K + + +L ERD SK E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634
Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
+EL ++ N ++ L A N++ A +L MQQ+ + + LEE++Q
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690
Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
+ + + + + L DQ N L + + L+ +++Q N+++ Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740
Score = 53.5 bits (127), Expect = 4e-07
Identities = 87/405 (21%), Positives = 174/405 (42%), Gaps = 62/405 (15%)
Query: 28 EQLTMNSEKSMHRKSTELVNEITCENTEWPGQ----RSTNFQIISSYPDDESVY-CTTEK 82
E + E + K T+L+ ++ EN + Q + N+Q SS+P E + +E+
Sbjct: 946 EAMLKERESDLSSK-TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 1004
Query: 83 YNVMEHRHNDMHY--ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKE 140
+ N++ + + + ++ +EK + ++ L ++ K LQ K+ K KE
Sbjct: 1005 EKEISGLWNELDSLKDAVEHQRKKNNDLREKN----WEAMEALASTEKMLQDKVNKTSKE 1060
Query: 141 QRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAK 200
+++ +EL+ KE K+ K + Y E ++ E +A
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE----------KKAKECMAGTS 1110
Query: 201 HMEMSLKVLENINPEENDM-TLQEL---LNRINNADTGIAIQKNGAIIVDRIYKTKECKM 256
E +KVLE+ E ++M TL +L + A+T +QK + R + +E K
Sbjct: 1111 GSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK-----LQRSVEQEENKW 1164
Query: 257 RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
++ +E I++ ++ + EQEL ++ +N+ N R + L+ +L
Sbjct: 1165 KVKVDESHKTIKQMQSSFTSS---EQELERLRSENKDIENLRR-------EREHLEMELE 1214
Query: 317 SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENI 376
+ R T V + ++L++ + L ++ L D +Y EA++ E +
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTEL------------QKKLDD-------SYSEAVRQNEEL 1255
Query: 377 VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
+ Q NE L T+L+ ER + L A+++ ++ K+ K
Sbjct: 1256 NLLKAQLNETL-TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVK 1299
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)
Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
+D+L+ + +Q L K K Q + K KL KE A ++ L +E+
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363
Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
+KER V++R++ +R + + ++ + + ++ M Q++ ++ A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418
Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
Q+NG + +++ + ++ ++ + L+ E K +L+QE
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475
Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
K Q + L AE E ++ + + A++ ++ E E+Q+L +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533
Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
L +L ++ L+ + + + ++ + E++ Q +QNE L Q+QQ ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593
Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
A E +V EK +++++ D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Score = 43.5 bits (101), Expect = 4e-04
Identities = 69/386 (17%), Positives = 158/386 (40%), Gaps = 86/386 (22%)
Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK------------ER 177
++++ A+ + Q+ L+ K +E E ++ ++ T LV + Q+ +
Sbjct: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNK 563
Query: 178 DEAVMSRLQLAIEERDEAIARAK--HMEMSLKVLENINPEENDMTLQELLNRINNADTGI 235
+E++ ++Q +E+ + A+ + H +++ + ++ EE + E +I + +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Query: 236 AIQKNGAIIVDRIYK---TKECKMRITAEEMSALIEERDAALSKCKRLEQELHH------ 286
A +++ + K ++ +++ AL E+ AA + ++++Q ++
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 287 -VKEQNQTS-ANNMRHLTAENNQERALKA------------------------------K 314
++EQ Q +N M N+Q +ALK+ K
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE-ENLK----DQFNYT------- 362
L ++++ ET + Q EEE+ +R S SL++E ++LK DQ ++
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENS---SLTKEVQDLKAKQNDQVSFASLVEELK 800
Query: 363 ---------LSTYEEALK-------NRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
+ + EE L+ N+E V +Q+ + L ++ E+A
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITS 860
Query: 407 HAREASQVANEKVQKLERLVDVLRKK 432
+E + K +++ + VL +K
Sbjct: 861 KVQELQNLLKGKEEQMNTMKAVLEEK 886
Score = 38.5 bits (88), Expect = 0.012
Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)
Query: 84 NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
+V E + + + + QV +SD K ++ + + + + +K+ Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169
Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
K + Q+K+ E +R EA L L E + E+ + K
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212
Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
+ EN+ +E + + ++NAD+ + K I V+ I K+ K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272
Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
++ +A ++ +D LS + E + +KE Q+ ++ LT +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332
Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
Q + L ++++ + K+L +E+ T + +S +KD+ + T
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383
Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
E+ +N + ++ Q+ +++ + QQ R ME ++ H ++ + + + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433
Score = 37.0 bits (84), Expect = 0.036
Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)
Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
E D+ A K + L + + E+ + + +LL +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321
Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
+ + ++ ++ +A+ E+ A +CK+L QE+ KE++ M+
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
+E + Q + Q+ ++++ + Q +R + ++EN L+D +
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435
Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
T + E N + +Q L +L + + E+Q ++A +A+ ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492
Query: 422 LER 424
ER
Sbjct: 493 AER 495
Score = 32.7 bits (73), Expect = 0.68
Identities = 73/385 (18%), Positives = 156/385 (40%), Gaps = 63/385 (16%)
Query: 107 SDKEKTIAFLLKELDILRTS------NKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIA 160
++KEKT+ L +E+ L+ K Q + + +E + L E Q +A +
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 161 EKTAALVEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEEN 217
EK L + Q +E +E++ + +Q +A EA + ++ E+ + + E +EN
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KEN 940
Query: 218 DMTLQELLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSAL 266
++ E + + +D +Q + +I + K+ + + EE+ +
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000
Query: 267 IEERDAALS----KCKRLEQELHHV-KEQNQTSANNMRHLTAENNQERALKAKLLSMQQA 321
I ER+ +S + L+ + H K+ N N + A + E+ L+ K+ +
Sbjct: 1001 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1060
Query: 322 RETAVQQYK-KLEEEIQTLRVYYSLHKSLSQ---------------------------EE 353
R+ V+ + + +E ++ L S+ +LS E
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEH 1120
Query: 354 NLK--DQFNYTLST----YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQH 407
LK D+ + L Y+ L E I+ Q+ E+ + + + E Q+Q
Sbjct: 1121 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQS 1180
Query: 408 AREASQVANEKVQKLERLVDVLRKK 432
+ +S+ E+++ + ++ LR++
Sbjct: 1181 SFTSSEQELERLRSENKDIENLRRE 1205
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 63.9 bits (154), Expect = 3e-10
Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)
Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
++ + K Q+++ K++ EQ + K++LQE +E ++ I ++TA ++
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
+ A++ +++ S+L + + + R M++ + +N EE+ M +Q++L +
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578
Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
I + IA Q + +++ + ++K K + + +L ERD SK E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634
Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
+EL ++ N ++ L A N++ A +L MQQ+ + + LEE++Q
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690
Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
+ + + + + L DQ N L + + L+ +++Q N+++ Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)
Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
+D+L+ + +Q L K K Q + K KL KE A ++ L +E+
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363
Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
+KER V++R++ +R + + ++ + + ++ M Q++ ++ A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418
Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
Q+NG + +++ + ++ ++ + L+ E K +L+QE
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475
Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
K Q + L AE E ++ + + A++ ++ E E+Q+L +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533
Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
L +L ++ L+ + + + ++ + E++ Q +QNE L Q+QQ ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593
Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
A E +V EK +++++ D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Score = 43.5 bits (101), Expect = 4e-04
Identities = 69/386 (17%), Positives = 158/386 (40%), Gaps = 86/386 (22%)
Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK------------ER 177
++++ A+ + Q+ L+ K +E E ++ ++ T LV + Q+ +
Sbjct: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNK 563
Query: 178 DEAVMSRLQLAIEERDEAIARAK--HMEMSLKVLENINPEENDMTLQELLNRINNADTGI 235
+E++ ++Q +E+ + A+ + H +++ + ++ EE + E +I + +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Query: 236 AIQKNGAIIVDRIYK---TKECKMRITAEEMSALIEERDAALSKCKRLEQELHH------ 286
A +++ + K ++ +++ AL E+ AA + ++++Q ++
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 287 -VKEQNQTS-ANNMRHLTAENNQERALKA------------------------------K 314
++EQ Q +N M N+Q +ALK+ K
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE-ENLK----DQFNYT------- 362
L ++++ ET + Q EEE+ +R S SL++E ++LK DQ ++
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENS---SLTKEVQDLKAKQNDQVSFASLVEELK 800
Query: 363 ---------LSTYEEALK-------NRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
+ + EE L+ N+E V +Q+ + L ++ E+A
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITS 860
Query: 407 HAREASQVANEKVQKLERLVDVLRKK 432
+E + K +++ + VL +K
Sbjct: 861 KVQELQNLLKGKEEQMNTMKAVLEEK 886
Score = 38.5 bits (88), Expect = 0.012
Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)
Query: 84 NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
+V E + + + + QV +SD K ++ + + + + +K+ Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169
Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
K + Q+K+ E +R EA L L E + E+ + K
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212
Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
+ EN+ +E + + ++NAD+ + K I V+ I K+ K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272
Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
++ +A ++ +D LS + E + +KE Q+ ++ LT +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332
Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
Q + L ++++ + K+L +E+ T + +S +KD+ + T
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383
Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
E+ +N + ++ Q+ +++ + QQ R ME ++ H ++ + + + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433
Score = 37.0 bits (84), Expect = 0.036
Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)
Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
E D+ A K + L + + E+ + + +LL +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321
Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
+ + ++ ++ +A+ E+ A +CK+L QE+ KE++ M+
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
+E + Q + Q+ ++++ + Q +R + ++EN L+D +
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435
Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
T + E N + +Q L +L + + E+Q ++A +A+ ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492
Query: 422 LER 424
ER
Sbjct: 493 AER 495
Score = 32.7 bits (73), Expect = 0.68
Identities = 71/365 (19%), Positives = 147/365 (40%), Gaps = 52/365 (14%)
Query: 107 SDKEKTIAFLLKELDILRTS------NKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIA 160
++KEKT+ L +E+ L+ K Q + + +E + L E Q +A +
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 161 EKTAALVEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEEN 217
EK L + Q +E +E++ + +Q +A EA + ++ E+ + + E +EN
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KEN 940
Query: 218 DMTLQELLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSAL 266
++ E + + +D +Q + +I + K+ + + EE+ +
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000
Query: 267 IEERDAALSKCKRLEQELHHVKE--QNQTSANNMRHLTAENNQERALKAKLLSMQQARET 324
I ER+ +S L EL +K+ ++Q NN R E + A + +
Sbjct: 1001 ISEREKEISG---LWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVP 1057
Query: 325 AVQQY--------KKLEE---------EIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYE 367
+ Y KK +E E++ L HK L + + + Y+
Sbjct: 1058 SNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLE-----HK-LKEADEMHTLLQLECEKYK 1111
Query: 368 EALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVD 427
L E I+ Q+ E+ + + + E Q+Q + +S+ E+++ + ++
Sbjct: 1112 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1171
Query: 428 VLRKK 432
LR++
Sbjct: 1172 NLRRE 1176
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 63.9 bits (154), Expect = 3e-10
Identities = 62/297 (20%), Positives = 142/297 (47%), Gaps = 36/297 (12%)
Query: 121 DILRTSNKKLQQKLAKEDKEQRKLKFKLELQE-----KETEAKIAEKTAAL------VEE 169
++ + K Q+++ K++ EQ + K++LQE +E ++ I ++TA ++
Sbjct: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQS 520
Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN-DMTLQELLNR- 227
+ A++ +++ S+L + + + R M++ + +N EE+ M +Q++L +
Sbjct: 521 KFVAKENEVQSLHSKLTDTLVSKQQLEQRL--MQLMESEQKRVNKEESLQMQVQDILEQN 578
Query: 228 ------INNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
I + IA Q + +++ + ++K K + + +L ERD SK E
Sbjct: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK----E 634
Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
+EL ++ N ++ L A N++ A +L MQQ+ + + LEE++Q
Sbjct: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ---- 690
Query: 342 YYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTER 398
+ + + + + L DQ N L + + L+ +++Q N+++ Q+++ + E+
Sbjct: 691 -HEISNKMEEFKILNDQ-NKALKSEVQKLQ-----TLVSEQPNKDVVEQMEKCIQEK 740
Score = 53.5 bits (127), Expect = 4e-07
Identities = 87/405 (21%), Positives = 174/405 (42%), Gaps = 62/405 (15%)
Query: 28 EQLTMNSEKSMHRKSTELVNEITCENTEWPGQ----RSTNFQIISSYPDDESVY-CTTEK 82
E + E + K T+L+ ++ EN + Q + N+Q SS+P E + +E+
Sbjct: 946 EAMLKERESDLSSK-TQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISER 1004
Query: 83 YNVMEHRHNDMHY--ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKE 140
+ N++ + + + ++ +EK + ++ L ++ K LQ K+ K KE
Sbjct: 1005 EKEISGLWNELDSLKDAVEHQRKKNNDLREKN----WEAMEALASTEKMLQDKVNKTSKE 1060
Query: 141 QRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAK 200
+++ +EL+ KE K+ K + Y E ++ E +A
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE----------KKAKECMAGTS 1110
Query: 201 HMEMSLKVLENINPEENDM-TLQEL---LNRINNADTGIAIQKNGAIIVDRIYKTKECKM 256
E +KVLE+ E ++M TL +L + A+T +QK + R + +E K
Sbjct: 1111 GSE-EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQK-----LQRSVEQEENKW 1164
Query: 257 RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
++ +E I++ ++ + EQEL ++ +N+ N R + L+ +L
Sbjct: 1165 KVKVDESHKTIKQMQSSFTSS---EQELERLRSENKDIENLRR-------EREHLEMELE 1214
Query: 317 SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENI 376
+ R T V + ++L++ + L ++ L D +Y EA++ E +
Sbjct: 1215 KAEMERSTYVTEVRELKDLLTEL------------QKKLDD-------SYSEAVRQNEEL 1255
Query: 377 VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
+ Q NE L T+L+ ER + L A+++ ++ K+ K
Sbjct: 1256 NLLKAQLNETL-TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVK 1299
Score = 45.8 bits (107), Expect = 8e-05
Identities = 64/330 (19%), Positives = 141/330 (42%), Gaps = 31/330 (9%)
Query: 120 LDILRTSNKKLQQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
+D+L+ + +Q L K K Q + K KL KE A ++ L +E+
Sbjct: 305 VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM-M 363
Query: 173 AQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNAD 232
+KER V++R++ +R + + ++ + + ++ M Q++ ++ A+
Sbjct: 364 TEKERSNVVITRMK----DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQME-AE 418
Query: 233 TGIAIQKNGAI------IVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHH 286
Q+NG + +++ + ++ ++ + L+ E K +L+QE
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE---LTEKTGKLQQEEVQ 475
Query: 287 VKEQNQTSANNMRHLT-AENNQERA---LKAKLLSMQQARETAVQQYKKLEEEIQTLRVY 342
K Q + L AE E ++ + + A++ ++ E E+Q+L +
Sbjct: 476 KKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL--H 533
Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQ---QQNEELATQLQQALTERA 399
L +L ++ L+ + + + ++ + E++ Q +QNE L Q+QQ ++ A
Sbjct: 534 SKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593
Query: 400 NMELQLQHAREASQVANEKVQKLERLVDVL 429
A E +V EK +++++ D L
Sbjct: 594 AQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Score = 43.5 bits (101), Expect = 4e-04
Identities = 69/386 (17%), Positives = 158/386 (40%), Gaps = 86/386 (22%)
Query: 130 LQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK------------ER 177
++++ A+ + Q+ L+ K +E E ++ ++ T LV + Q+ +
Sbjct: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNK 563
Query: 178 DEAVMSRLQLAIEERDEAIARAK--HMEMSLKVLENINPEENDMTLQELLNRINNADTGI 235
+E++ ++Q +E+ + A+ + H +++ + ++ EE + E +I + +
Sbjct: 564 EESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSL 623
Query: 236 AIQKNGAIIVDRIYK---TKECKMRITAEEMSALIEERDAALSKCKRLEQELHH------ 286
A +++ + K ++ +++ AL E+ AA + ++++Q ++
Sbjct: 624 ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 287 -VKEQNQTS-ANNMRHLTAENNQERALKA------------------------------K 314
++EQ Q +N M N+Q +ALK+ K
Sbjct: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQE-ENLK----DQFNYT------- 362
L ++++ ET + Q EEE+ +R S SL++E ++LK DQ ++
Sbjct: 744 LKTVEELLETGLIQVATKEEELNAIRTENS---SLTKEVQDLKAKQNDQVSFASLVEELK 800
Query: 363 ---------LSTYEEALK-------NRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
+ + EE L+ N+E V +Q+ + L ++ E+A
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITS 860
Query: 407 HAREASQVANEKVQKLERLVDVLRKK 432
+E + K +++ + VL +K
Sbjct: 861 KVQELQNLLKGKEEQMNTMKAVLEEK 886
Score = 38.5 bits (88), Expect = 0.012
Identities = 64/353 (18%), Positives = 143/353 (40%), Gaps = 46/353 (13%)
Query: 84 NVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRK 143
+V E + + + + QV +SD K ++ + + + + +K+ Q+K
Sbjct: 110 SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKK 169
Query: 144 LKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHME 203
K + Q+K+ E +R EA L L E + E+ + K
Sbjct: 170 SKNGSDDQDKKV-------------ETLMVPSKRQEA----LPLHQETKQESGSGKKKAS 212
Query: 204 MSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAI------IVDRIYKTKECKMR 257
+ EN+ +E + + ++NAD+ + K I V+ I K+ K++
Sbjct: 213 SKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLK 272
Query: 258 ITAEEMSALIEERDAALSKCKRLEQE------LHHVKE-----QNQTSANNMRHLTAENN 306
++ +A ++ +D LS + E + +KE Q+ ++ LT +
Sbjct: 273 TETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIH 332
Query: 307 QERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTY 366
Q + L ++++ + K+L +E+ T + +S +KD+ + T
Sbjct: 333 QLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEK-----ERSNVVITRMKDR----IGTL 383
Query: 367 EEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKV 419
E+ +N + ++ Q+ +++ + QQ R ME ++ H ++ + + + V
Sbjct: 384 EKEHNVFQNKIHVSYQETQQMQMKFQQV---REQMEAEIAHLKQENGILRDAV 433
Score = 37.0 bits (84), Expect = 0.036
Identities = 46/243 (18%), Positives = 102/243 (41%), Gaps = 30/243 (12%)
Query: 191 ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYK 250
E D+ A K + L + + E+ + + +LL +K+G +I D + K
Sbjct: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK-----------EKSG-VIQDALKK 321
Query: 251 TKECKMRITAEEM-------SALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTA 303
+ + ++ ++ +A+ E+ A +CK+L QE+ KE++ M+
Sbjct: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
Query: 304 ENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNY 361
+E + Q + Q+ ++++ + Q +R + ++EN L+D +
Sbjct: 382 TLEKEHNV------FQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSN 435
Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
T + E N + +Q L +L + + E+Q ++A +A+ ++Q+
Sbjct: 436 TTNQLESKQSAELNKL---RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQE 492
Query: 422 LER 424
ER
Sbjct: 493 AER 495
Score = 32.7 bits (73), Expect = 0.68
Identities = 73/385 (18%), Positives = 156/385 (40%), Gaps = 63/385 (16%)
Query: 107 SDKEKTIAFLLKELDILRTS------NKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIA 160
++KEKT+ L +E+ L+ K Q + + +E + L E Q +A +
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 161 EKTAALVEEVYFAQ--KERDEAVMSRLQ-LAIEERDEAIARAKHMEMSLKVLENINPEEN 217
EK L + Q +E +E++ + +Q +A EA + ++ E+ + + E +EN
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKE----KEN 940
Query: 218 DMTLQELLNRINNADTGIA------IQKNGAIIVDRIYKTKECKMRITA-----EEMSAL 266
++ E + + +D +Q + +I + K+ + + EE+ +
Sbjct: 941 ELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKV 1000
Query: 267 IEERDAALS----KCKRLEQELHHV-KEQNQTSANNMRHLTAENNQERALKAKLLSMQQA 321
I ER+ +S + L+ + H K+ N N + A + E+ L+ K+ +
Sbjct: 1001 ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKE 1060
Query: 322 RETAVQQYK-KLEEEIQTLRVYYSLHKSLSQ---------------------------EE 353
R+ V+ + + +E ++ L S+ +LS E
Sbjct: 1061 RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEH 1120
Query: 354 NLK--DQFNYTLST----YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQH 407
LK D+ + L Y+ L E I+ Q+ E+ + + + E Q+Q
Sbjct: 1121 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQS 1180
Query: 408 AREASQVANEKVQKLERLVDVLRKK 432
+ +S+ E+++ + ++ LR++
Sbjct: 1181 SFTSSEQELERLRSENKDIENLRRE 1205
>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
Length = 284
Score = 63.9 bits (154), Expect = 3e-10
Identities = 71/284 (25%), Positives = 124/284 (43%), Gaps = 42/284 (14%)
Query: 119 ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERD 178
EL L+ K + +L K + + + KLEL EK+ A+ A+L + ++E D
Sbjct: 42 ELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEAD-VASLNRRIQLVEEELD 100
Query: 179 EAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIAI 237
A RL A+++ +EA A E +KV+E+ +E M +QE+ ++ A
Sbjct: 101 RA-QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEI--QLKEA------ 151
Query: 238 QKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANN 297
K+ A DR Y+ K+ I ++ E + + KC LE+EL +T NN
Sbjct: 152 -KHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEEL-------KTVTNN 203
Query: 298 MRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKD 357
++ L A+ E Q+ + EEEI+ L L + E +
Sbjct: 204 LKSLEAQ-----------------AEKYSQKEDRYEEEIKV------LSDKLKEAETRAE 240
Query: 358 QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANM 401
+++ E+++ + E V+ +++N + L Q L E NM
Sbjct: 241 FAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
Score = 33.5 bits (75), Expect = 0.40
Identities = 31/130 (23%), Positives = 59/130 (45%), Gaps = 18/130 (13%)
Query: 298 MRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKD 357
M L EN +RA +A + ++ A + K+LE+E+ SL K L E+ D
Sbjct: 10 MLKLDKENALDRAEQA-----EADKKAAEDRSKQLEDEL------VSLQKKLKGTEDELD 58
Query: 358 QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ Y EALK+ + + + +++ + + +E +L A+E A +
Sbjct: 59 K-------YSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQ 111
Query: 418 KVQKLERLVD 427
K+++ E+ D
Sbjct: 112 KLEEAEKAAD 121
Score = 29.3 bits (64), Expect = 7.5
Identities = 35/165 (21%), Positives = 75/165 (45%), Gaps = 22/165 (13%)
Query: 269 ERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQ 328
++ AA + K+LE EL ++++ + + + + + ALK Q+ E A ++
Sbjct: 28 DKKAAEDRSKQLEDELVSLQKKLKGTEDEL------DKYSEALK----DAQEKLELAEKK 77
Query: 329 YKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELA 388
E ++ SL++ + E D+ L+T + L+ E +++ + +
Sbjct: 78 ATDAEADVA------SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIE 131
Query: 389 TQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
++ Q+ + ME+Q +EA +A + +K E +V RK V
Sbjct: 132 SRAQK---DEEKMEIQEIQLKEAKHIAEDADRKYE---EVARKLV 170
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 63.9 bits (154), Expect = 3e-10
Identities = 65/328 (19%), Positives = 138/328 (42%), Gaps = 56/328 (17%)
Query: 107 SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAAL 166
S KE+ +++L +L + K+Q ++ +++ + L +LE+Q KE + +I + L
Sbjct: 1402 SKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVEL 1461
Query: 167 VE-----EVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTL 221
E E + + + +LQ A+ R EA+ K ++ L + T+
Sbjct: 1462 CEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG--------TI 1513
Query: 222 QELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE 281
+ L + + ++ ++ Q ++ T ++ + EE LI E D +L
Sbjct: 1514 ERLTKSLADVESQVSAQ-------NKEKDTVLGRLALLQEERDKLITEMDRSLL------ 1560
Query: 282 QELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV 341
+ ++L + S++ A E + +KL +EI++L+
Sbjct: 1561 -------------------------ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595
Query: 342 YYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRE---NIVSITQQQNEELATQLQQALT 396
+ QE++ L+ ++ L +YE E ++V +Q+ +EL +L+
Sbjct: 1596 SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEA 1655
Query: 397 ERANMELQLQHAREASQVANEKVQKLER 424
+ E QLQ A + + EK++K +
Sbjct: 1656 NKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
Score = 57.0 bits (136), Expect = 3e-08
Identities = 78/377 (20%), Positives = 167/377 (44%), Gaps = 70/377 (18%)
Query: 108 DKEKTIAFLLKELDILRTSNKK--------LQQKLAKEDKEQRKL-KFKLELQEKETEA- 157
+K + +K L+ ++T ++K L Q + K Q +L FK+ L + ++EA
Sbjct: 2033 EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA 2092
Query: 158 -------KIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVL- 209
K+ ++ + E V K++DE + RL+ A E+ + K+M+ L L
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKH---LKEKKNMQEKLDALR 2149
Query: 210 -ENINPEENDMTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSALI 267
E ++ EE T+ E+ +N D + +Q+N + ++ + MS+L
Sbjct: 2150 REKVHLEE---TIGEIQVTLNKKDKEVQQLQEN--------LDSTVTQLAAFTKSMSSLQ 2198
Query: 268 EERDAALSKCKRLEQELH----------HVKEQN-QTSANNMRHLTAENNQERALKAKLL 316
++RD + + K+ E++ +KE N + +R ++ + + ++L
Sbjct: 2199 DDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLE 2258
Query: 317 SMQQARETAVQQYKKLEEEI----------------QTLRVYYSLHKSLSQEEN----LK 356
+Q E+ Q +L++++ +T +Y+S L++ E+ LK
Sbjct: 2259 HDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLK 2318
Query: 357 DQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVAN 416
DQ ++ E+ + + N+ I +QQ + +Q + +E LQ +RE + +
Sbjct: 2319 DQLTDLSNSLEKCKEQKGNLEGIIRQQEAD----IQNSKFSYEQLETDLQASRELTSRLH 2374
Query: 417 EKV-QKLERLVDVLRKK 432
E++ K ++++ +L K
Sbjct: 2375 EEINMKEQKIISLLSGK 2391
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/332 (19%), Positives = 140/332 (42%), Gaps = 60/332 (18%)
Query: 131 QQKLAKEDK-------EQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
+++L+K DK E K+K KL+ +E+ A+ T A E+ + E +E VM
Sbjct: 129 EEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM 188
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ--------ELLNRINNADTGI 235
+ QL +E + +A+ + + E D + ELL + AD
Sbjct: 189 KQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVET 248
Query: 236 AIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSA 295
+Q+ K+R+ ++ E L+QEL +++NQ +
Sbjct: 249 EMQQ---------------KLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS 293
Query: 296 NNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENL 355
++ + AE+N R +++ RE + +K+E E+ ++ + NL
Sbjct: 294 QQLQQMEAEHNTLRN------TVETEREESKILLEKMELEVAERKLSF---------HNL 338
Query: 356 KDQFNYTLSTYEEALKNRENIVS----ITQQQNEELATQLQQALT-ERANMELQ------ 404
+++ ++ L +E+A + + + S + Q+ E+ + L+ ++ ELQ
Sbjct: 339 QEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDAL 398
Query: 405 ----LQHAREASQVANEKVQKLERLVDVLRKK 432
+ ++ ++ A + Q +++L D L++K
Sbjct: 399 KDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQK 430
Score = 45.4 bits (106), Expect = 1e-04
Identities = 76/341 (22%), Positives = 138/341 (40%), Gaps = 38/341 (11%)
Query: 102 QVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAE 161
QVT+ +E T+ +L + +L + K +L+ +L +KE K+ E
Sbjct: 2617 QVTA-LQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGE 2675
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTL 221
L +E+ D +M EER +AR +EM K+L + E +T
Sbjct: 2676 IEDKLKKEL--KHLHHDAGIMRNETETAEERVAELARDL-VEMEQKLLM-VTKENKGLTA 2731
Query: 222 QELLNRINNADTGIAIQKNGAII-VDRIYKTKECKMRITAE--EMSALIEERDAALSKCK 278
Q + + + + ++ A +D + + + ++ A+ E L ERDA LS+
Sbjct: 2732 Q--IQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSET- 2788
Query: 279 RLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETA---VQQYKKLEEE 335
N T N++ HL N Q + +LL + E + VQ + K
Sbjct: 2789 --------AFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMAS 2840
Query: 336 IQTLR--VYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELA----- 388
+Q R ++ L K EE K + ST +++ + +S Q + L
Sbjct: 2841 LQNERDHLWNELEKFRKSEEG-KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899
Query: 389 -----TQLQQALTERANMELQLQHARE---ASQVANEKVQK 421
Q+ Q +TE ++ QLQ ++ A Q+ E++++
Sbjct: 2900 LQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ 2940
Score = 43.5 bits (101), Expect = 4e-04
Identities = 67/332 (20%), Positives = 140/332 (42%), Gaps = 61/332 (18%)
Query: 119 ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKET----------EAKIAEKTAALVE 168
++++L+ +Q + +++ R L+ +L+ +E E +K+ E + AL +
Sbjct: 811 KIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQ 870
Query: 169 --------EVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDM- 219
+ +K+RD + LQ IEE+D+ + M+ K+++ +N E+ +
Sbjct: 871 KELEITKMDQLLLEKKRD---VETLQQTIEEKDQQVTEIS-FSMTEKMVQ-LNEEKFSLG 925
Query: 220 ----TLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKM----RITAEEMS------- 264
TL+E LN ++ A+ Q V K +M +I+ EE+
Sbjct: 926 VEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLK 985
Query: 265 -----------ALIEERDAALSKCKRLEQELHHVKEQNQTS---ANNMRHLTAEN--NQE 308
A + R L + RLE+EL ++K++++ + R E+ N+E
Sbjct: 986 KENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKE 1045
Query: 309 RALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEE 368
+ K Q+ Q + E E+Q +R K L ++ ++QF + +
Sbjct: 1046 YSEKCVTSKCQEIEIYLKQTISEKEVELQHIR------KDLEEKLAAEEQFQALVKQMNQ 1099
Query: 369 ALKNRENIVSITQQQNEELATQLQQALTERAN 400
L+++ N + + Q + E +Q+ +T +
Sbjct: 1100 TLQDKTNQIDLLQAEISENQAIIQKLITSNTD 1131
Score = 43.1 bits (100), Expect = 5e-04
Identities = 68/360 (18%), Positives = 142/360 (39%), Gaps = 42/360 (11%)
Query: 92 DMHYECMTPCQVTSDSDKEKTIAF---LLKEL-DILRTSNKKLQQKLAKEDKEQRKLKFK 147
++H E T+ D ++ +A+ L+ EL DI+R + +LQQK +E++ K
Sbjct: 33 ELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNK 92
Query: 148 LELQEKETEAKIAEKTAALVE-----EVYFAQKERDEAVMSRLQLAIEERDEAIARAKHM 202
++ + +AK+ + E + + E +S+ + E + I + KH
Sbjct: 93 IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHK 152
Query: 203 EMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEE 262
+ L + + E + + + K + T + ++ T E
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212
Query: 263 MSA--LIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQ 320
+A ++ E+DA RL ++ + L + + E ++ KL +Q
Sbjct: 213 QAAQQVVREKDARFETQVRLHED-------------ELLQLVTQADVETEMQQKLRVLQ- 258
Query: 321 ARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALK----NRENI 376
+KLEE ++L + L QE +Q N LS + ++ N
Sbjct: 259 ---------RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNT 309
Query: 377 VSITQQQNEELATQLQQALTERA----NMELQLQHAREASQVANEKVQKLERLVDVLRKK 432
V +++++ L +++ + ER N++ ++ H E + A + +LE L +K
Sbjct: 310 VETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQK 369
Score = 42.7 bits (99), Expect = 7e-04
Identities = 72/340 (21%), Positives = 150/340 (44%), Gaps = 57/340 (16%)
Query: 107 SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAAL 166
S K+ + L +E+ + N+++Q++L++ K LK E ++ + E ++ + A L
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTK----LKETAEEEKDDLEERLMNQLAEL 1933
Query: 167 -------VEEVYFAQKERD--EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEEN 217
++V AQ + + E+ M L+ + E +E + + ++ KV I
Sbjct: 1934 NGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE--KQQLVKEKTKVESEIR---- 1987
Query: 218 DMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKC 277
+E L +I A KE + A+E+ L++E+ +
Sbjct: 1988 ----KEYLEKIQGAQ-------------------KEPGNKSHAKELQELLKEKQ---QEV 2021
Query: 278 KRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQ 337
K+L+++ ++ Q + SA E Q + K ++ + + AV+ KK + E+
Sbjct: 2022 KQLQKDC--IRYQEKISALERTVKALEFVQTESQKDLEITKENLAQ-AVEHRKKAQAELA 2078
Query: 338 TLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQA--- 394
+ +V +S + L D L +E N+E++ S +Q++E+L +L+QA
Sbjct: 2079 SFKVLLDDTQSEAARV-LADN----LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 395 -LTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
L E+ NM+ +L R E + +++ ++ K+V
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV 2173
Score = 40.8 bits (94), Expect = 0.002
Identities = 68/343 (19%), Positives = 143/343 (41%), Gaps = 40/343 (11%)
Query: 110 EKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE 169
E T + KEL +L K+ Q+++A KL+LQ K E E ++++
Sbjct: 549 ENTFSQKHKELSVLLLEMKEAQEEIAF---------LKLQLQGKRAE----EADHEVLDQ 595
Query: 170 VYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN--INPEENDMTLQELLNR 227
Q E + ++++ +E+ + + E SL +E + E T +E+
Sbjct: 596 KEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI--S 653
Query: 228 INNADTGI-AIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKC-----KRLE 281
+N+A + + +++G + + +C E + + I E + K K L+
Sbjct: 654 LNDAGVELKSTKQDGDKSLSAVPDIGQCHQD-ELERLKSQILELELNFHKAQEIYEKNLD 712
Query: 282 QELHHVKEQNQ-------TSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEE 334
++ + NQ + NN TA + + L +++ + E Q K+LE
Sbjct: 713 EKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQ-VKQLEM 771
Query: 335 EIQTLRVYYSL-HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQ 393
+ L ++S + +NL + ++LS K+++ + + Q + +++ Q +
Sbjct: 772 NLAEAERQRRLDYESQTAHDNLLTEQIHSLSI---EAKSKDVKIEVLQNELDDVQLQFSE 828
Query: 394 ALTERANMELQLQHAREASQVANEKVQ----KLERLVDVLRKK 432
T +++ QLQ+ E+V+ K+E L L +K
Sbjct: 829 QSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQK 871
Score = 39.3 bits (90), Expect = 0.007
Identities = 79/454 (17%), Positives = 179/454 (39%), Gaps = 62/454 (13%)
Query: 28 EQLTMNSEKSMHRKSTELVNEITCENTEWPGQRST---NFQIISSYPDDESVYCTTEKYN 84
E LT + EK + ++ L + E+TEW + ++I+ ++ S ++
Sbjct: 1577 EGLTEDKEKLV-KEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHV 1635
Query: 85 VMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKL----QQKLAKEDKE 140
V R + + EK + +E++ ++ +K QQK+ + ++E
Sbjct: 1636 VEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695
Query: 141 QRKLKFKLELQ---EKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIA 197
+L+ ++ KE + A++ EE+ + E E + + Q + E+D
Sbjct: 1696 NDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY-ETLSKKFQSLMSEKDSLSE 1754
Query: 198 RAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIA-----IQKNGAIIV------- 245
+ ++ ++ N++ + N ++ N+ N + G ++ ++ +
Sbjct: 1755 EVQDLKHQIE--GNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCS 1812
Query: 246 DRIYKTKECKMRITAE-----EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
+ + K ++ + E++ +++ D + LE+E KE +QT N
Sbjct: 1813 ESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNT 1872
Query: 301 LTAENN---------QERALKAKLLSMQ---------QARETAVQQYKKLEEEIQTLRVY 342
L ++ + QE K LL+ Q + +ETA ++ LEE + +
Sbjct: 1873 LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL--MNQL 1930
Query: 343 YSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANME 402
L+ S+ E +KN + VS +++ ++L + + +E
Sbjct: 1931 AELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY 1990
Query: 403 LQ-----------LQHAREASQVANEKVQKLERL 425
L+ HA+E ++ EK Q++++L
Sbjct: 1991 LEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024
Score = 36.2 bits (82), Expect = 0.061
Identities = 85/407 (20%), Positives = 162/407 (39%), Gaps = 90/407 (22%)
Query: 80 TEKYNVMEHRHNDMHYE-CMTP-CQVT------SDSDKEKTIAFLLKELD---------- 121
TE+ V E + N + E C+T CQ + S+KE + + K+L+
Sbjct: 1032 TERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091
Query: 122 -ILRTSNKKLQQKLAKEDKEQRKLKFKLELQEK----ETEAKIAEKTAAL---------- 166
+++ N+ LQ K + D Q ++ + +K T+A + A +
Sbjct: 1092 ALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPC 1151
Query: 167 ----------VEEVYFAQKERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEE 216
+EE A ++ E + +LQ A+ R + +A+ E L+ E + ++
Sbjct: 1152 TGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR--EELKQQK 1209
Query: 217 NDMT-LQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
+D LQE + + + I Q I ++ ++ + K+ T ++ S S
Sbjct: 1210 DDYNRLQEQFDEQSKENENIGDQLRQLQI--QVRESIDGKLPSTDQQESC---------S 1258
Query: 276 KCKRLEQELHHVKEQNQT----SANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKK 331
LE+ L EQ+ T +N + + AL+ T+V Q K
Sbjct: 1259 STPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQG---------GTSVAQIKA 1309
Query: 332 LEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEE-LATQ 390
+EI+ +V L S ST E K E + + +Q N++ L +
Sbjct: 1310 QLKEIEAEKVELELKVS---------------STTSELTKKSEEVFQLQEQINKQGLEIE 1354
Query: 391 LQQALTERANMELQ-LQHAREASQV---ANEKVQKLERLVDVLRKKV 433
+ ++ A + + LQ E+SQ+ E +++L+ +D L+K +
Sbjct: 1355 SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI 1401
>gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]
Length = 285
Score = 63.5 bits (153), Expect = 4e-10
Identities = 65/226 (28%), Positives = 102/226 (45%), Gaps = 16/226 (7%)
Query: 119 ELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERD 178
EL ++ K + +L K + + + KLEL EK+ AE A+L + ++E D
Sbjct: 43 ELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAE-VASLNRRIQLVEEELD 101
Query: 179 EAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIAI 237
A RL A+++ +EA A E +KV+EN +E M LQE+ ++ A
Sbjct: 102 RA-QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI--QLKEA------ 152
Query: 238 QKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQ-NQTSAN 296
K+ A DR Y+ K+ I ++ E + A SKC LE+EL +V A
Sbjct: 153 -KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQ 211
Query: 297 NMRHLTAENNQERALKA---KLLSMQQARETAVQQYKKLEEEIQTL 339
++ E+ E +K KL + E A + KLE+ I L
Sbjct: 212 AEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDL 257
Score = 35.8 bits (81), Expect = 0.080
Identities = 40/182 (21%), Positives = 75/182 (41%), Gaps = 16/182 (8%)
Query: 256 MRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNM----RHLTAENNQERAL 311
M ++M L +++ AL + ++ E E +E+++ + + + L ++
Sbjct: 2 MEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKY 61
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALK 371
L Q+ E A ++ E E+ SL++ + E D+ L+T AL+
Sbjct: 62 SEALKDAQEKLELAEKKAADAEAEVA------SLNRRIQLVEEELDRAQERLAT---ALQ 112
Query: 372 NRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRK 431
E + + +AL + MELQ +EA +A E +K E +V RK
Sbjct: 113 KLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE---EVARK 169
Query: 432 KV 433
V
Sbjct: 170 LV 171
Score = 34.3 bits (77), Expect = 0.23
Identities = 26/93 (27%), Positives = 47/93 (50%), Gaps = 11/93 (11%)
Query: 107 SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLE-LQEKETEAKIAEKTAA 165
S+ E+ + + L L +K QK EDK + ++K + L+E ET A+ AE++ A
Sbjct: 192 SELEEELKNVTNNLKSLEAQAEKYSQK---EDKYEEEIKILTDKLKEAETRAEFAERSVA 248
Query: 166 LVEEVY-------FAQKERDEAVMSRLQLAIEE 191
+E+ +AQK + +A+ L A+ +
Sbjct: 249 KLEKTIDDLEDELYAQKLKYKAISEELDHALND 281
>gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]
Length = 248
Score = 62.8 bits (151), Expect = 6e-10
Identities = 70/282 (24%), Positives = 123/282 (43%), Gaps = 42/282 (14%)
Query: 117 LKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKE 176
L L+ ++ + LQQ+ + + + L+ +L+ E+E K AAL + ++E
Sbjct: 4 LNSLEAVKRKIQALQQQADEAEDRAQGLQRELD-GERERREKAEGDVAALNRRIQLVEEE 62
Query: 177 RDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGI 235
D A RL A+++ +EA A E +KV+EN +E M +QE+ ++ A
Sbjct: 63 LDRA-QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEM--QLKEA---- 115
Query: 236 AIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSA 295
K+ A DR Y+ K+ I E+ E + + KC LE+EL +V
Sbjct: 116 ---KHIAEEADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNV-------T 165
Query: 296 NNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENL 355
NN++ S++ A E ++ K EEEI+ L L + E
Sbjct: 166 NNLK-----------------SLEAASEKYSEKEDKYEEEIKL------LSDKLKEAETR 202
Query: 356 KDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE 397
+ T++ E+ + + E ++ +++N L L Q L E
Sbjct: 203 AEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNE 244
Score = 33.9 bits (76), Expect = 0.30
Identities = 32/136 (23%), Positives = 58/136 (42%), Gaps = 14/136 (10%)
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRV--------YYSLHKSLSQEENLKD 357
N A+K K+ ++QQ + A + + L+ E+ R +L++ + E D
Sbjct: 5 NSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVEEELD 64
Query: 358 QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ L+T AL+ E + + +A+ + ME+Q +EA +A E
Sbjct: 65 RAQERLAT---ALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEE 121
Query: 418 KVQKLERLVDVLRKKV 433
+K E +V RK V
Sbjct: 122 ADRKYE---EVARKLV 134
>gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens]
Length = 247
Score = 62.8 bits (151), Expect = 6e-10
Identities = 65/244 (26%), Positives = 111/244 (45%), Gaps = 18/244 (7%)
Query: 120 LDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDE 179
++ ++ + LQQ+ ++ +L+ ++E + + E AE A+L + ++E D
Sbjct: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAE-VASLNRRIQLVEEELDR 65
Query: 180 AVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTGIAIQ 238
A RL A+++ +EA A E +KV+EN +E M LQE+ ++ A
Sbjct: 66 A-QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI--QLKEA------- 115
Query: 239 KNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQ-NQTSANN 297
K+ A DR Y+ K+ I ++ E + A SKC LE+EL +V A
Sbjct: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQA 175
Query: 298 MRHLTAENNQERALKA---KLLSMQQARETAVQQYKKLEEEIQTL--RVYYSLHKSLSQE 352
++ E+ E +K KL + E A + KLE+ I L R+Y L ++
Sbjct: 176 EKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLS 235
Query: 353 ENLK 356
LK
Sbjct: 236 NELK 239
Score = 36.6 bits (83), Expect = 0.047
Identities = 34/132 (25%), Positives = 59/132 (44%), Gaps = 14/132 (10%)
Query: 310 ALKAKLLSMQQARETAVQQYKKLEEEIQTLR--------VYYSLHKSLSQEENLKDQFNY 361
A+K K+ +QQ + A ++ ++L+ E++ R SL++ + E D+
Sbjct: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
Query: 362 TLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQK 421
L+T AL+ E + + +AL + MELQ +EA +A E +K
Sbjct: 69 RLAT---ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRK 125
Query: 422 LERLVDVLRKKV 433
E +V RK V
Sbjct: 126 YE---EVARKLV 134
Score = 35.4 bits (80), Expect = 0.10
Identities = 26/93 (27%), Positives = 48/93 (51%), Gaps = 11/93 (11%)
Query: 107 SDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLE-LQEKETEAKIAEKTAA 165
S+ E+ + + L L +K QK EDK + ++K + L+E ET A+ AE++ A
Sbjct: 155 SELEEELKNVTNNLKSLEAQAEKYSQK---EDKYEEEIKILTDKLKEAETRAEFAERSVA 211
Query: 166 LVE-------EVYFAQKERDEAVMSRLQLAIEE 191
+E E ++Q ER+ + + L+L + +
Sbjct: 212 KLEKTIDDLEERLYSQLERNRLLSNELKLTLHD 244
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 62.8 bits (151), Expect = 6e-10
Identities = 97/470 (20%), Positives = 199/470 (42%), Gaps = 56/470 (11%)
Query: 1 MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELV-NEITCENTEWPGQ 59
MEN S +T + E TT + + L M E K E++ NEI E
Sbjct: 467 MENQS--LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 60 RSTNFQIISSYPDDESVYCT----TEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAF 115
++ + ++ E T +E+ + + N+ + ++ + S E +
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 116 LLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK 175
+ KE IL S K+ KL+K + E+R++K +LE +++ E+ L E++ +K
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK-----GERAEELENELHHLEK 639
Query: 176 ERD--EAVMSRLQL------AIEERDEAIARA-----------KHMEMSLKVLENINPE- 215
E + + ++ L++ A+E+ + + R K++ L+ LE N +
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 216 -ENDMTLQELLNRINNADTGIA-IQ-------------KNGAIIVDRIYKTKECKMRITA 260
E ++ L+ + + A +A +Q K G ++ +K E ++ ++
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSY 758
Query: 261 E----EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
+ E L + + + K ++LE EL ++ +NQT N+ L + + L+ +
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 317 SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLK----DQFNYTLSTYEEALKN 372
S++Q + K+LE+E + LR + + +E N+K ++ N TLS K
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 373 RENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKL 422
+ +++N+EL + + + L + +Q N ++KL
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/349 (20%), Positives = 158/349 (45%), Gaps = 45/349 (12%)
Query: 119 ELDILRTSN---KKLQQKLAKEDKEQRKLKF-KLELQEKETEAKIAEKTAALVEEVYFAQ 174
ELD LR KL+ ++++ + ++F K ++E + + ++ +T ++E+
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 175 KERDEAV----MSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ-------- 222
+ R + + LQL + D + R +M K +E + E +MTL+
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER----DMDRKKIEELM--EENMTLEMAQKQSMD 424
Query: 223 -------ELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
EL ++ A QK+ V+ + ++ K+ + + ++ +EE +
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 276 KCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEE 335
+ ++ ++++NQ + + L E QE K L + Q + +++ +LE+
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQE---KQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 336 IQTLRVYYSLHKSLSQEENLKDQFNYTLSTY--------EEALKNRENIVSITQQQNEEL 387
I+TLR + ++EN + N T+S+ E +K+ E I + +E
Sbjct: 542 IETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET 599
Query: 388 ATQLQQALTERANMELQLQHAREASQVANE---KVQKLERLVDVLRKKV 433
+++L + E+ ++ +L+H +E + A E ++ LE+ ++L+KK+
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Score = 41.2 bits (95), Expect = 0.002
Identities = 87/473 (18%), Positives = 184/473 (38%), Gaps = 64/473 (13%)
Query: 1 MENWSKDITHSYLEQETTGINKSTQ-PDEQLTMNSE--------KSMHRKSTELVNEITC 51
M N + +TH E E G+NK DEQ T +S +S +KS E+ E
Sbjct: 921 MNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIA 977
Query: 52 ENTEWPGQRSTNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEK 111
E + STN+ + + + + Y ++ R ++ +P D+ E+
Sbjct: 978 A-LEARLEESTNY----NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 112 TIAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVY 171
+EL L+ ++ ++ + + K K +L++ ET+ + ++
Sbjct: 1033 ESQETTREL--LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
Query: 172 FAQKERDEAVMS---RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRI 228
+ +E++ + + +LQ+ + + L + ++ EN+ ++E +
Sbjct: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150
Query: 229 NNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVK 288
+ D+ I + ++ +R A E +LI + S K LE E ++
Sbjct: 1151 SLYDSLIKDHEKLELLHER-----------QASEYESLISKHGTLKSAHKNLEVEHRDLE 1199
Query: 289 EQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS---- 344
++ L + + K+L + ET +YKKL E L YS
Sbjct: 1200 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Query: 345 ---------------LHKSLSQEENLKDQFNYTLSTYEE------ALKNRENIVS----I 379
L+ S ++ L+ +F+ Y++ L N+ ++S
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGN 1319
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKK 432
+++N L Q+Q + + + Q +++ V E+ Q +++L ++ R+K
Sbjct: 1320 LEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1370
Score = 33.9 bits (76), Expect = 0.30
Identities = 61/278 (21%), Positives = 110/278 (39%), Gaps = 42/278 (15%)
Query: 190 EERDEAIARAKHMEMSLK------VLENINPEENDMTLQELLNRINNADTGIAIQKNGAI 243
++++E I R + ++ K + E + +EN LQ + + + + KN A+
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Query: 244 IVDRIYKTKECKMRITAEEMSALIEERD----------AALSKC-----KRLEQELHHVK 288
+ R+ ++ +E + L EERD +A S C KR E H
Sbjct: 196 HLKRLIDERDEH----SETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV 251
Query: 289 EQNQTSANNMR---HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSL 345
E A R L + Q K +L M+ + Q+ L + ++ R+Y
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 346 HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL 405
+L ++ D+ +S Y+E L + + + + EEL Q L + +E QL
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 406 QHAREASQVANE----------KVQKLERLVDVLRKKV 433
+ R S +E K+ +E D+ RKK+
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 62.8 bits (151), Expect = 6e-10
Identities = 97/470 (20%), Positives = 199/470 (42%), Gaps = 56/470 (11%)
Query: 1 MENWSKDITHSYLEQETTGINKSTQPDEQLTMNSEKSMHRKSTELV-NEITCENTEWPGQ 59
MEN S +T + E TT + + L M E K E++ NEI E
Sbjct: 467 MENQS--LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 60 RSTNFQIISSYPDDESVYCT----TEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAF 115
++ + ++ E T +E+ + + N+ + ++ + S E +
Sbjct: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Query: 116 LLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK 175
+ KE IL S K+ KL+K + E+R++K +LE +++ E+ L E++ +K
Sbjct: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK-----GERAEELENELHHLEK 639
Query: 176 ERD--EAVMSRLQL------AIEERDEAIARA-----------KHMEMSLKVLENINPE- 215
E + + ++ L++ A+E+ + + R K++ L+ LE N +
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 216 -ENDMTLQELLNRINNADTGIA-IQ-------------KNGAIIVDRIYKTKECKMRITA 260
E ++ L+ + + A +A +Q K G ++ +K E ++ ++
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSY 758
Query: 261 E----EMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
+ E L + + + K ++LE EL ++ +NQT N+ L + + L+ +
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 317 SMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLK----DQFNYTLSTYEEALKN 372
S++Q + K+LE+E + LR + + +E N+K ++ N TLS K
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 373 RENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKL 422
+ +++N+EL + + + L + +Q N ++KL
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/349 (20%), Positives = 158/349 (45%), Gaps = 45/349 (12%)
Query: 119 ELDILRTSN---KKLQQKLAKEDKEQRKLKF-KLELQEKETEAKIAEKTAALVEEVYFAQ 174
ELD LR KL+ ++++ + ++F K ++E + + ++ +T ++E+
Sbjct: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 175 KERDEAV----MSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ-------- 222
+ R + + LQL + D + R +M K +E + E +MTL+
Sbjct: 371 RARSDKLHELEKENLQLKAKLHDMEMER----DMDRKKIEELM--EENMTLEMAQKQSMD 424
Query: 223 -------ELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
EL ++ A QK+ V+ + ++ K+ + + ++ +EE +
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 276 KCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEE 335
+ ++ ++++NQ + + L E QE K L + Q + +++ +LE+
Sbjct: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQE---KQSLQNCQNLSKDLMKEKAQLEKT 541
Query: 336 IQTLRVYYSLHKSLSQEENLKDQFNYTLSTY--------EEALKNRENIVSITQQQNEEL 387
I+TLR + ++EN + N T+S+ E +K+ E I + +E
Sbjct: 542 IETLRENSERQIKILEQEN--EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET 599
Query: 388 ATQLQQALTERANMELQLQHAREASQVANE---KVQKLERLVDVLRKKV 433
+++L + E+ ++ +L+H +E + A E ++ LE+ ++L+KK+
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Score = 41.2 bits (95), Expect = 0.002
Identities = 85/472 (18%), Positives = 183/472 (38%), Gaps = 63/472 (13%)
Query: 1 MENWSKDITHSYLEQETTGINK--------STQPDEQLTMNSEKSMHRKSTELVNEITCE 52
M N + +TH E E G+NK ST +L + +S +KS E+ E
Sbjct: 921 MNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAA 977
Query: 53 NTEWPGQRSTNFQIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKT 112
E + STN+ + + + + Y ++ R ++ +P D+ E+
Sbjct: 978 -LEARLEESTNY----NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1032
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
+EL L+ ++ ++ + + K K +L++ ET+ + ++
Sbjct: 1033 SQETTREL--LKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090
Query: 173 AQKERDEAVMS---RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRIN 229
+ +E++ + + +LQ+ + + L + ++ EN+ ++E + +
Sbjct: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150
Query: 230 NADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKE 289
D+ I + ++ +R A E +LI + S K LE E +++
Sbjct: 1151 LYDSLIKDHEKLELLHER-----------QASEYESLISKHGTLKSAHKNLEVEHRDLED 1199
Query: 290 QNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS----- 344
+ L + + K+L + ET +YKKL E L YS
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259
Query: 345 --------------LHKSLSQEENLKDQFNYTLSTYEE------ALKNRENIVS----IT 380
L+ S ++ L+ +F+ Y++ L N+ ++S
Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1319
Query: 381 QQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKK 432
+++N L Q+Q + + + Q +++ V E+ Q +++L ++ R+K
Sbjct: 1320 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1369
Score = 33.9 bits (76), Expect = 0.30
Identities = 61/278 (21%), Positives = 110/278 (39%), Gaps = 42/278 (15%)
Query: 190 EERDEAIARAKHMEMSLK------VLENINPEENDMTLQELLNRINNADTGIAIQKNGAI 243
++++E I R + ++ K + E + +EN LQ + + + + KN A+
Sbjct: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Query: 244 IVDRIYKTKECKMRITAEEMSALIEERD----------AALSKC-----KRLEQELHHVK 288
+ R+ ++ +E + L EERD +A S C KR E H
Sbjct: 196 HLKRLIDERDEH----SETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSV 251
Query: 289 EQNQTSANNMR---HLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSL 345
E A R L + Q K +L M+ + Q+ L + ++ R+Y
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 346 HKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL 405
+L ++ D+ +S Y+E L + + + + EEL Q L + +E QL
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHD----IEFYKARVEELKEDNQVLLETKTMLEDQL 367
Query: 406 QHAREASQVANE----------KVQKLERLVDVLRKKV 433
+ R S +E K+ +E D+ RKK+
Sbjct: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKI 405
>gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens]
Length = 284
Score = 62.0 bits (149), Expect = 1e-09
Identities = 71/252 (28%), Positives = 112/252 (44%), Gaps = 18/252 (7%)
Query: 116 LLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQK 175
L +E L+ K + ++ K + ++ + KLE EK+ A+ A+L + ++
Sbjct: 39 LEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEAD-VASLNRRIQLVEE 97
Query: 176 ERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLEN-INPEENDMTLQELLNRINNADTG 234
E D A RL A+++ +EA A E +KV+EN +E M LQE+ ++ A
Sbjct: 98 ELDRA-QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEM--QLKEA--- 151
Query: 235 IAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQ-NQT 293
K+ A DR Y+ K+ I E+ E + A SKC LE+EL V
Sbjct: 152 ----KHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSL 207
Query: 294 SANNMRHLTAENNQE---RALKAKLLSMQQARETAVQQYKKLEEEIQTL--RVYYSLHKS 348
A ++ T E+ E + L+ KL + E A + KLE+ I L VY K
Sbjct: 208 EAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKY 267
Query: 349 LSQEENLKDQFN 360
+ E L + N
Sbjct: 268 KAISEELDNALN 279
Score = 35.4 bits (80), Expect = 0.10
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 12/88 (13%)
Query: 116 LLKELDILRTSNKKLQQKL----AKEDKEQRKLKFKLE-LQEKETEAKIAEKTAALVEEV 170
L +EL I+ + K L+ + KEDK + ++K E L+E ET A+ AE++ A +E+
Sbjct: 193 LEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKT 252
Query: 171 Y-------FAQKERDEAVMSRLQLAIEE 191
+AQK + +A+ L A+ +
Sbjct: 253 IDDLEDEVYAQKMKYKAISEELDNALND 280
Score = 34.3 bits (77), Expect = 0.23
Identities = 39/179 (21%), Positives = 76/179 (42%), Gaps = 15/179 (8%)
Query: 255 KMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAK 314
KM++ + I+ + A + K+ E ++E+ Q ++ E+ E+ +
Sbjct: 7 KMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKG--TEDEVEKYSE-- 62
Query: 315 LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRE 374
S+++A+E Q KK + + SL++ + E D+ L+T AL+ E
Sbjct: 63 --SVKEAQEKLEQAEKKATDAEADVA---SLNRRIQLVEEELDRAQERLAT---ALQKLE 114
Query: 375 NIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKV 433
+ + +A+ + MELQ +EA +A + +K E +V RK V
Sbjct: 115 EAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE---EVARKLV 170
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 62.0 bits (149), Expect = 1e-09
Identities = 83/352 (23%), Positives = 150/352 (42%), Gaps = 53/352 (15%)
Query: 104 TSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDKEQRKL----KFKLELQEKETEAKI 159
T D E+ L+K++ ++L+ +L +++++QR L K K+E+ K+ EA+I
Sbjct: 1582 TRDEQNEEKKRLLIKQV-------RELEAEL-EDERKQRALAVASKKKMEIDLKDLEAQI 1633
Query: 160 AEKTAALVEEVYFAQKERDEAVMSRLQLAIEE----RDEAIARAKHMEMSLKVLENINPE 215
A E + Q + +A M Q +EE RDE A++K E LK LE
Sbjct: 1634 EAANKARDEVI--KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLE----- 1686
Query: 216 ENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALS 275
+ LQE L A +++ + D I + K SAL++E+ +
Sbjct: 1687 AEILQLQEELASSERARRHAEQERDE--LADEITNSASGK--------SALLDEKRRLEA 1736
Query: 276 KCKRLEQELHHVKEQNQTSANNMRHLTAE----NNQERALKAKLLSMQQARETAVQQYKK 331
+ +LE+EL + + + R T + N + A ++ AR+ +Q K+
Sbjct: 1737 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 332 LEEEIQTLRVYYS----------------LHKSLSQEENLKDQFNYTLSTYEEALKNREN 375
L+ ++Q L L + L QE + N + E+ LK
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFM 1856
Query: 376 IVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVD 427
V ++ ++ Q+++A ++ QL+ A E + AN +KL+R +D
Sbjct: 1857 QVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELD 1908
Score = 55.1 bits (131), Expect = 1e-07
Identities = 75/379 (19%), Positives = 165/379 (43%), Gaps = 49/379 (12%)
Query: 96 ECMTPCQVTSDSDKEKTIAFLLKELDILRTSNKKLQQKLAKEDK---EQRKLKFKLELQE 152
EC + Q+ + +K K +A + + +++ + L+++L KE+K E K K KL+ +
Sbjct: 1010 ECSS--QLAEEEEKAKNLAKIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 153 KETEAKIAEKTAALVE-EVYFAQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLE 210
+ + +IAE A + E ++ A+KE + + ++R ++ A+ + ++ + L+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124
Query: 211 ---------NINPEENDMTLQELLNRI-----NNADTGIAIQKNGAIIVDRIYKTKECKM 256
E+ L E L + + DT A Q+ + + K+
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 257 RITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLL 316
T + + + R + + L ++L K N + L + N+E A + K+L
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD-NKELACEVKVL 1243
Query: 317 SMQQARETAVQQYKKLEEEIQTL--------RVYYSLHKSLSQEENLKD----------- 357
QQ + + + KKL+ ++Q L R+ L + S+ +N D
Sbjct: 1244 --QQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK 1301
Query: 358 ---QFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQV 414
+F ++ E L++ + ++ +Q L+++++Q E+ +++ Q + EA +
Sbjct: 1302 KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Query: 415 ANEKVQKLERLVDVLRKKV 433
++V L+ + +KKV
Sbjct: 1362 LEKQVLALQSQLADTKKKV 1380
Score = 50.1 bits (118), Expect = 4e-06
Identities = 76/413 (18%), Positives = 177/413 (42%), Gaps = 35/413 (8%)
Query: 14 EQETTGINKSTQPD---EQLTMNSEKSMHRKSTELVNEITCENTEWPGQRSTNFQIISSY 70
EQE + K+ + + + + + H + E ++E + + N Q + +
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET- 1231
Query: 71 PDDESVYCTTEKYNVM----EHRHNDMHYECMTPCQVTSDSDKEKT-----IAFLLKELD 121
D++ + C + + EH+ + + S+ D+ + + L ELD
Sbjct: 1232 -DNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELD 1290
Query: 122 ILRTSNKKLQQKLAKEDKEQRKLKFKL----ELQEKETEAKI--AEKTAALVEEVYFAQK 175
+ T ++ ++K K K+ L+ +L EL ++ET K+ + + L EE Q+
Sbjct: 1291 NVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Query: 176 ERDEAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRI-NNADTG 234
+++E +R L E+ +++ + KV +++ E+ L+E ++ +A+
Sbjct: 1351 QQEEEEEARKNL---EKQVLALQSQLADTKKKVDDDLGTIES---LEEAKKKLLKDAEAL 1404
Query: 235 IAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHV-KEQNQT 293
+ A+ D++ KTK +++ ++++ ++ + S ++ +++ + E+
Sbjct: 1405 SQRLEEKALAYDKLEKTKN-RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 294 SANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEE 353
SA + R + K LS+ +A E A++ ++ E + + LR +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRA------DMEDLM 1517
Query: 354 NLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQ 406
+ KD + E++ + E V + Q EEL +LQ + +E+ +Q
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570
Score = 37.0 bits (84), Expect = 0.036
Identities = 40/195 (20%), Positives = 79/195 (40%), Gaps = 19/195 (9%)
Query: 250 KTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQE- 308
K K+ K+ EEM E + L + K + E + + A MR A QE
Sbjct: 865 KEKQTKVEGELEEM----ERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQEL 920
Query: 309 ----RALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLS 364
L++++ ++ + + KK++ IQ L + L +EE + +
Sbjct: 921 EEILHDLESRVEEEEERNQILQNEKKKMQAHIQ------DLEEQLDEEEGARQKLQLEKV 974
Query: 365 TYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQL----QHAREASQVANEKVQ 420
T E +K E + + + QN + + + A QL + A+ +++ N++
Sbjct: 975 TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034
Query: 421 KLERLVDVLRKKVGT 435
+ L + L+K+ T
Sbjct: 1035 MISDLEERLKKEEKT 1049
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1867
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 1868 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1915
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2096 ARVQAEREAAQSRRQV 2111
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2034
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2152
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2210
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2268
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2269 EAEKMKQVAE 2278
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1383
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1429
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1550 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELER 1633
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 1972 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2082
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2139
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2183
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2239
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2240 LSKLKARIEAENRALILRDKDNT 2262
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2170 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2288 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2399
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2400 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2250
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2251 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2301 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2418 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 431 KK 432
K
Sbjct: 2471 LK 2472
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1696
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1755
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1756 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1813
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1814 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1856
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1857 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1913
Query: 426 VDVLRKK 432
D LR++
Sbjct: 1914 EDTLRQR 1920
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1532
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1533 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1639
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1640 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 419 VQKL 422
++L
Sbjct: 1697 QRQL 1700
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2325 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1356 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1405
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1454
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1455 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1813 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1871
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 1872 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1919
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2100 ARVQAEREAAQSRRQV 2115
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2038
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2098
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2099 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2156
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2214
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2215 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2272
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2273 EAEKMKQVAE 2282
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1338 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1387
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1433
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1493
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1494 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1553
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1554 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELER 1637
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 1976 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2086
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2087 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2143
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2187
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2243
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2244 LSKLKARIEAENRALILRDKDNT 2266
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2174 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2292 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2347
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2403
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2404 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2579 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2254
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2255 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2304
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2305 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2422 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474
Query: 431 KK 432
K
Sbjct: 2475 LK 2476
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1700
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1701 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1759
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1760 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1817
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1818 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1860
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1861 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1917
Query: 426 VDVLRKK 432
D LR++
Sbjct: 1918 EDTLRQR 1924
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1418 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1536
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1537 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1587
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1588 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1643
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1644 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1700
Query: 419 VQKL 422
++L
Sbjct: 1701 QRQL 1704
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2329 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2567 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1360 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1409
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1410 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1458
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1459 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1513
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1867
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 1868 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1915
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2096 ARVQAEREAAQSRRQV 2111
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2034
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2094
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2095 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2152
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2210
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2268
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2269 EAEKMKQVAE 2278
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1334 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1383
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1429
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1489
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1490 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1549
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1550 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELER 1633
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 1972 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2082
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2139
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2183
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2239
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2240 LSKLKARIEAENRALILRDKDNT 2262
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2170 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2288 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2399
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2400 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2575 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2250
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2251 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2300
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2301 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2418 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470
Query: 431 KK 432
K
Sbjct: 2471 LK 2472
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1696
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1697 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1755
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1756 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1813
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1814 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1856
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1857 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1913
Query: 426 VDVLRKK 432
D LR++
Sbjct: 1914 EDTLRQR 1920
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1414 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1532
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1533 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1583
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1584 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1639
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1640 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1696
Query: 419 VQKL 422
++L
Sbjct: 1697 QRQL 1700
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2325 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2563 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1356 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1405
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1406 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1454
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1455 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1509
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1777 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1835
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 1836 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1883
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1943
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2003
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2064 ARVQAEREAAQSRRQV 2079
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2002
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2062
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2063 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2120
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2121 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2178
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2179 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2236
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2237 EAEKMKQVAE 2246
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1302 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1351
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1397
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1457
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1458 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1517
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1518 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELER 1601
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 1940 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2050
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2051 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2107
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2151
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2152 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2207
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2208 LSKLKARIEAENRALILRDKDNT 2230
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2138 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2256 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2311
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2367
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2368 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2543 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2218
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2219 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2268
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2269 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2386 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438
Query: 431 KK 432
K
Sbjct: 2439 LK 2440
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1664
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1665 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1723
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1724 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1781
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1782 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1824
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1825 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1881
Query: 426 VDVLRKK 432
D LR++
Sbjct: 1882 EDTLRQR 1888
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1382 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1500
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1501 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1551
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1552 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1607
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1608 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1664
Query: 419 VQKL 422
++L
Sbjct: 1665 QRQL 1668
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2293 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2531 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1324 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1373
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1374 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1422
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1423 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1477
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1946 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 2004
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 2005 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 2052
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2172
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2233 ARVQAEREAAQSRRQV 2248
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2171
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2232 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2289
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2347
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2405
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2406 EAEKMKQVAE 2415
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1520
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1566
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1626
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1627 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1686
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1687 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELER 1770
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 2109 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2219
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2220 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2276
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2320
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2321 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2376
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2377 LSKLKARIEAENRALILRDKDNT 2399
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2307 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2425 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2480
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2536
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2537 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2387
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2388 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2437
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2438 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2555 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607
Query: 431 KK 432
K
Sbjct: 2608 LK 2609
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1833
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1892
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1893 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1950
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1951 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1993
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1994 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 2050
Query: 426 VDVLRKK 432
D LR++
Sbjct: 2051 EDTLRQR 2057
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1551 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1669
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1670 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1720
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1721 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1776
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1777 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833
Query: 419 VQKL 422
++L
Sbjct: 1834 QRQL 1837
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2462 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2700 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1493 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1542
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1543 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1591
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1592 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1787 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1845
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 1846 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1893
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2013
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2074 ARVQAEREAAQSRRQV 2089
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2012
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2073 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2130
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2188
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2189 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2246
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2247 EAEKMKQVAE 2256
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1361
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1407
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1467
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1468 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1527
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1528 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELER 1611
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 1950 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2060
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2061 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2117
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2161
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2162 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2217
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2218 LSKLKARIEAENRALILRDKDNT 2240
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2148 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2266 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2321
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2377
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2378 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2228
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2229 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2278
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2279 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2396 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448
Query: 431 KK 432
K
Sbjct: 2449 LK 2450
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1674
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1733
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1734 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1791
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1792 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1834
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1835 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1891
Query: 426 VDVLRKK 432
D LR++
Sbjct: 1892 EDTLRQR 1898
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1392 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1510
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1511 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1561
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1562 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1617
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1618 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
Query: 419 VQKL 422
++L
Sbjct: 1675 QRQL 1678
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2303 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2420
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2421 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2481 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2540
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2541 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1334 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1383
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1384 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1432
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1433 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1795 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1853
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 1854 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1901
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1961
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2021
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2082 ARVQAEREAAQSRRQV 2097
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2020
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2080
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2081 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2138
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2139 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2196
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2197 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2254
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2255 EAEKMKQVAE 2264
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1320 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1369
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1415
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1475
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1476 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1535
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1536 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELER 1619
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 1958 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2068
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2069 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2125
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2169
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2170 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2225
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2226 LSKLKARIEAENRALILRDKDNT 2248
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2156 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2274 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2329
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2385
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2386 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2561 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2236
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2237 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2286
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2287 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2404 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456
Query: 431 KK 432
K
Sbjct: 2457 LK 2458
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1682
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1683 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1741
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1742 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1799
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1800 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1842
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1843 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1899
Query: 426 VDVLRKK 432
D LR++
Sbjct: 1900 EDTLRQR 1906
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1400 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1459
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1518
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1519 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1569
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1570 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1625
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1626 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1682
Query: 419 VQKL 422
++L
Sbjct: 1683 QRQL 1686
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2311 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2428
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2429 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2489 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2548
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2549 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1342 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1391
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1392 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1440
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1441 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1495
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 62.0 bits (149), Expect = 1e-09
Identities = 79/316 (25%), Positives = 136/316 (43%), Gaps = 29/316 (9%)
Query: 134 LAKEDKEQRKLKFK-LELQEKETEAKIAEKTAALVE------EVYFAQKERDEAVMSRLQ 186
LA+E K QR+L + Q E E +AEK AA+ E E A KE+ EA RL+
Sbjct: 1836 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK-EAENERLR 1894
Query: 187 LAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVD 246
E DEA R + E + ++ ++E L ++ A +++ ++ D
Sbjct: 1895 RLAE--DEAFQRRRLEEQAA---------QHKADIEERLAQLRKASDS-ELERQKGLVED 1942
Query: 247 RIYKTKECKMRITA-----EEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHL 301
+ + ++ + I A E+ +A E + L + + ++ KEQ + A R L
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2002
Query: 302 TAENNQERA-LKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQ--EENLKDQ 358
AE + R + ++ A E A +Q K EE++ L+ + L + E+ Q
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2062
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNE-ELATQLQQALTERANMELQLQHAREASQVANE 417
++ L+ E + QQ E EL LQQ + + + + AR A++ A E
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 418 KVQKLERLVDVLRKKV 433
+ ER R++V
Sbjct: 2123 ARVQAEREAAQSRRQV 2138
Score = 51.2 bits (121), Expect = 2e-06
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 21/310 (6%)
Query: 124 RTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMS 183
R + +++Q+ LA E++ R+ K LE E+ A VEE ++ ++
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEE---------VERLKAKVEEARRLRERAEQESAR 2061
Query: 184 RLQLAIE---ERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKN 240
+LQLA E +R +A +A + K E + + ++ + L A A +
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2121
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A + + + AE + EE+ A ++ + ++L KE Q +A +
Sbjct: 2122 EARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--KEAEQEAARRAQA 2179
Query: 301 LTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFN 360
A Q++A A++ ++ E ++Q ++E+E+ TLR+ L ++ Q+ L ++
Sbjct: 2180 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL--QLEETDHQKNLLDEELQ 2237
Query: 361 YTLSTYEEALKNRENI---VSITQQQNEELATQLQQALTERANMELQLQHAREASQVANE 417
+ EA + R + + + Q EEL+ +A E N L L+ + E
Sbjct: 2238 RLKAEATEAARQRSQVEEELFSVRVQMEELSK--LKARIEAENRALILRDKDNTQRFLQE 2295
Query: 418 KVQKLERLVD 427
+ +K++++ +
Sbjct: 2296 EAEKMKQVAE 2305
Score = 49.7 bits (117), Expect = 5e-06
Identities = 68/326 (20%), Positives = 135/326 (41%), Gaps = 40/326 (12%)
Query: 113 IAFLLKELDILRTSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYF 172
I F+ + L + + +Q+ A+E + +++ LE Q + EA K
Sbjct: 1361 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK---------- 1410
Query: 173 AQKERD-EAVMSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNA 231
AQ ER+ + + R+Q + R+EA A+ + S++ +EL ++
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--------------EELQQLRQSS 1456
Query: 232 DTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLE---QELHHVK 288
+ I + A +R E ++R+ ++ A +R A + + L +E K
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQK 1516
Query: 289 EQNQTSANNM-RHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVY-YSLH 346
Q Q A + R + E+ ++R + +L S +A A ++ ++ + ++ LR+
Sbjct: 1517 RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAE 1576
Query: 347 KSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTE--------R 398
+ L Q E ++ E A ++ E + + E QL+++L E R
Sbjct: 1577 RRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634
Query: 399 ANMELQLQHAREASQVANEKVQKLER 424
E + Q EA + E ++LER
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELER 1660
Score = 49.3 bits (116), Expect = 7e-06
Identities = 69/323 (21%), Positives = 138/323 (42%), Gaps = 50/323 (15%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIE 190
Q++LA E++ +R+ E +E+ ++ AE+ AA + + ER +A + + E
Sbjct: 1999 QRQLAAEEERRRR-----EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 191 ERDEAIARAKHM-----EMSLKVLENINP---EENDMTLQELLNRINNADTGIAIQKNGA 242
++ AR + + L+ E + ++ + LQ+ L + + + Q G
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ----EQSVLDQLRGE 2109
Query: 243 IIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLT 302
R + + R+ AE +A + + K+ +E + Q Q +A +R
Sbjct: 2110 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLR--- 2166
Query: 303 AENNQERALKAK----LLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
E QE A +A+ L +QA + ++++KK E QTLR K Q
Sbjct: 2167 KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE--QTLR--------------QKAQ 2210
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L+T L+ ++ ++ ++ + L + +A +R+ +E +L R V E+
Sbjct: 2211 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR----VQMEE 2266
Query: 419 VQKLERLVD------VLRKKVGT 435
+ KL+ ++ +LR K T
Sbjct: 2267 LSKLKARIEAENRALILRDKDNT 2289
Score = 47.0 bits (110), Expect = 3e-05
Identities = 88/450 (19%), Positives = 174/450 (38%), Gaps = 56/450 (12%)
Query: 10 HSYLEQETTGINKSTQPDEQLT---MNSEKSMHRKST--ELVNEITCENTEWPGQRSTNF 64
H ++T + + Q +++LT + E++ H+K+ E + + E TE QRS
Sbjct: 2197 HKKFAEQT--LRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254
Query: 65 QIISSYPDDESVYCTTEKYNVMEHRHNDMHYECMTPCQVTSDSDKEKTIAFLLKELDILR 124
+ + S + E+R + + T + +++K K +A L +
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2314
Query: 125 TSNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSR 184
+L+Q LA+ED Q++ + L+EK + ++ L E Q++++ A
Sbjct: 2315 QEAARLRQ-LAEEDLAQQRALAEKMLKEK---MQAVQEATRLKAEAELLQQQKELAQEQA 2370
Query: 185 LQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAII 244
+L ++ A A+ + + LE + +M+ + ++ A+ A +
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA---- 2426
Query: 245 VDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAE 304
+ + R AEE+ + + A + L Q L ++Q+ A +R AE
Sbjct: 2427 -----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481
Query: 305 NNQERAL---KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNY 361
+E+ +AKLL ++ VQQ + L+E + + S SL Q E +Q
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541
Query: 362 TL---------------------------------STYEEALKNRENIVSITQQQNEELA 388
L ++ EEA + + +++ EEL
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Query: 389 TQLQQALTERANMELQLQHAREASQVANEK 418
QQ + + + Q RE Q+ E+
Sbjct: 2602 QLEQQRRQQEELLAEENQRLREQLQLLEEQ 2631
Score = 46.2 bits (108), Expect = 6e-05
Identities = 57/302 (18%), Positives = 127/302 (42%), Gaps = 23/302 (7%)
Query: 133 KLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRLQLAIEER 192
+L E+ + +K ELQ + EA A + + VEE F+ + + E +S+L+ IE
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEAE 2277
Query: 193 DEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTK 252
+ A+ + + N + E + ++ +++ A + ++ +
Sbjct: 2278 NRALI----------LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED 2327
Query: 253 ECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-ERAL 311
+ R AE+M ++E+ A+ + RL+ E +++Q + + R L + Q + L
Sbjct: 2328 LAQQRALAEKM---LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 312 KAKLLSMQQARETAVQQYKKLEEEIQTLRVYYS-LHKSLSQEENLKDQFNYTLSTYEEAL 370
+ Q+ E Q+ ++ E + L++ + + ++ ++ E +F E L
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 371 KNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLR 430
T+ +E T +Q +R + + REA + +KL++ +L+
Sbjct: 2445 HR-------TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2497
Query: 431 KK 432
K
Sbjct: 2498 LK 2499
Score = 45.8 bits (107), Expect = 8e-05
Identities = 68/307 (22%), Positives = 127/307 (41%), Gaps = 24/307 (7%)
Query: 126 SNKKLQQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEEVYFAQKERDEAVMSRL 185
+N+ L+ +L E+ Q+K + E ++++ EA+ + EE Q+E E + +
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1723
Query: 186 QLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIV 245
Q + E A E+ E E+ L+E L R+ + A QK +
Sbjct: 1724 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-EAAAATQKRQELEA 1782
Query: 246 DRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAEN 305
+ E ++ + A + A E R + +RLE E +E + +A +R L E
Sbjct: 1783 ELAKVRAEMEV-LLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA-RLRALAEEA 1840
Query: 306 NQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLST 365
++R Q A E A +Q + E RV ++ + LK + L
Sbjct: 1841 KRQR---------QLAEEDAARQRAEAE------RVLAEKLAAIGEATRLKTEAEIAL-- 1883
Query: 366 YEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERL 425
+E E + + + + + +QA +A++E +L R+AS E+ + L +
Sbjct: 1884 -KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL--V 1940
Query: 426 VDVLRKK 432
D LR++
Sbjct: 1941 EDTLRQR 1947
Score = 43.1 bits (100), Expect = 5e-04
Identities = 64/304 (21%), Positives = 130/304 (42%), Gaps = 29/304 (9%)
Query: 131 QQKLAKEDKEQRKLKFKLELQEKETEAKIAEKTAALVEE---VYFAQKERDE----AVMS 183
Q++ +E+ +Q + + E+Q K +A+ AE++ +EE V Q E E
Sbjct: 1441 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1500
Query: 184 RLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQ---ELLNRINNADTGIAIQKN 240
LQ +EA A+ + + + L +E+ Q EL +R+ A+ A +K
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV-KAEAEAAREKQ 1559
Query: 241 GAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRH 300
A+ ++R+ AEE + R A + + ++++ L + + + R
Sbjct: 1560 RALQALE-------ELRLQAEEAERRL--RQAEVERARQVQVALETAQRSAEAELQSKRA 1610
Query: 301 LTAENNQ--ERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQ 358
AE ER+L+ + +++ Q RE A ++ +++ + R + L + + LK
Sbjct: 1611 SFAEKTAQLERSLQEEHVAVAQLREEA---ERRAQQQAEAERAREEAERELERWQ-LKAN 1666
Query: 359 FNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEK 418
L E + ++ S+ Q + E+ + ++ R E Q RE ++ EK
Sbjct: 1667 EALRLRLQAEEVAQQK---SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1723
Query: 419 VQKL 422
++L
Sbjct: 1724 QRQL 1727
Score = 41.2 bits (95), Expect = 0.002
Identities = 66/295 (22%), Positives = 126/295 (42%), Gaps = 34/295 (11%)
Query: 116 LLKELDILRTSNKKLQQKLAK---EDKEQRKLKFKLELQ------EKETEAKI-----AE 161
L E ++L+ K+L Q+ A+ EDKEQ + E Q E E + ++ AE
Sbjct: 2352 LKAEAELLQ-QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410
Query: 162 KTAALVEEVYFAQKERDEAVMSRLQLAIEERDEAIAR---AKHMEMSLKVLENINPEEND 218
+ V E+ AQ +E R + EE E + R A +++L I +++D
Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQ-RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2469
Query: 219 MTLQELLNRINNADTGIA-IQKNGAIIVDRIYKTKECKMRITAEEMSAL----IEERDAA 273
+ L I + +Q+ ++ + + + + +E AL + E+D+
Sbjct: 2470 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529
Query: 274 LSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQ-----ERALKAKLLSMQQARET---A 325
L + + +EQE +++ Q + L E + E+ + + SM++AR A
Sbjct: 2530 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2589
Query: 326 VQQYKKLEEEIQTLRVYYSLHKSLSQEEN--LKDQFNYTLSTYEEALKNRENIVS 378
+ ++ +EE+Q L + L EEN L++Q + AL + E + +
Sbjct: 2590 EEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
Score = 36.2 bits (82), Expect = 0.061
Identities = 39/180 (21%), Positives = 77/180 (42%), Gaps = 26/180 (14%)
Query: 260 AEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQ 319
AEE L E +AAL K ++L + K Q + A + ++ ++ +++ +
Sbjct: 1383 AEERERLAEV-EAALEKQRQLAEAHAQAKAQAEREAKEL---------QQRMQEEVVRRE 1432
Query: 320 QARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSI 379
+A A QQ + ++EE+Q LR S E ++ + + L+ E I
Sbjct: 1433 EAAVDAQQQKRSIQEELQQLRQ--------SSEAEIQAKARQAEAAERSRLRIEEEI--- 1481
Query: 380 TQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMR 439
+ QL+ +R E +LQ R ++ A + ++ + + LR++V + R
Sbjct: 1482 -----RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1536
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.123 0.324
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,042,544
Number of Sequences: 37866
Number of extensions: 588637
Number of successful extensions: 6716
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 119
Number of HSP's successfully gapped in prelim test: 823
Number of HSP's that attempted gapping in prelim test: 3977
Number of HSP's gapped (non-prelim): 2595
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.