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Search of human proteins with 23097308
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23097308 spectrin repeat containing, nuclear envelope 1
isoform 2 [Homo sapiens]
(8749 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 1.708e+04 0.0
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 1.690e+04 0.0
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof... 6468 0.0
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 2085 0.0
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 2055 0.0
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof... 1947 0.0
gi|33624873 spectrin repeat containing, nuclear envelope 2 isofo... 363 4e-99
gi|33188445 microfilament and actin filament cross-linker protei... 355 1e-96
gi|221316624 dystonin isoform 4 [Homo sapiens] 336 7e-91
gi|221316622 dystonin isoform 3 [Homo sapiens] 336 7e-91
gi|221316618 dystonin isoform 2 [Homo sapiens] 336 7e-91
gi|34577047 dystonin isoform 1 [Homo sapiens] 336 7e-91
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 336 7e-91
gi|33188443 microfilament and actin filament cross-linker protei... 328 2e-88
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 310 5e-83
gi|33624861 spectrin repeat containing, nuclear envelope 2 isofo... 309 9e-83
gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens] 308 2e-82
gi|5032283 dystrophin Dp427m isoform [Homo sapiens] 306 8e-82
gi|110611228 utrophin [Homo sapiens] 290 4e-77
gi|145580592 nesprin-3 [Homo sapiens] 285 1e-75
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 266 7e-70
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 263 4e-69
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 263 6e-69
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 262 1e-68
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 261 2e-68
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 261 3e-68
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 260 4e-68
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 260 4e-68
gi|19923599 calmin [Homo sapiens] 259 6e-68
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 237 3e-61
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
[Homo sapiens]
Length = 8749
Score = 1.708e+04 bits (44329), Expect = 0.0
Identities = 8749/8749 (100%), Positives = 8749/8749 (100%)
Query: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG
Sbjct: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
Query: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD 120
VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD
Sbjct: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD 120
Query: 121 IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 180
IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT
Sbjct: 121 IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 180
Query: 181 TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 240
TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR
Sbjct: 181 TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 240
Query: 241 SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 300
SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ
Sbjct: 241 SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 300
Query: 301 EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 360
EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH
Sbjct: 301 EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 360
Query: 361 FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 420
FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT
Sbjct: 361 FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 420
Query: 421 IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 480
IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN
Sbjct: 421 IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 480
Query: 481 GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 540
GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR
Sbjct: 481 GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 540
Query: 541 ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 600
ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ
Sbjct: 541 ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 600
Query: 601 WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 660
WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW
Sbjct: 601 WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 660
Query: 661 IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 720
IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY
Sbjct: 661 IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 720
Query: 721 TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 780
TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI
Sbjct: 721 TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 780
Query: 781 TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 840
TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK
Sbjct: 781 TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 840
Query: 841 INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 900
INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD
Sbjct: 841 INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 900
Query: 901 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 960
QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK
Sbjct: 901 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 960
Query: 961 GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1020
GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG
Sbjct: 961 GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1020
Query: 1021 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1080
EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL
Sbjct: 1021 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1080
Query: 1081 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1140
CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF
Sbjct: 1081 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1140
Query: 1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1200
SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE
Sbjct: 1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1200
Query: 1201 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1260
VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK
Sbjct: 1201 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1260
Query: 1261 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1320
EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE
Sbjct: 1261 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1320
Query: 1321 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1380
LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE
Sbjct: 1321 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1380
Query: 1381 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1440
SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT
Sbjct: 1381 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1440
Query: 1441 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1500
LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI
Sbjct: 1441 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1500
Query: 1501 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1560
ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ
Sbjct: 1501 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1560
Query: 1561 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1620
QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS
Sbjct: 1561 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1620
Query: 1621 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1680
ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER
Sbjct: 1621 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1680
Query: 1681 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1740
GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK
Sbjct: 1681 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1740
Query: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800
MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE
Sbjct: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800
Query: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1860
ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF
Sbjct: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1860
Query: 1861 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1920
EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL
Sbjct: 1861 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1920
Query: 1921 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1980
QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA
Sbjct: 1921 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1980
Query: 1981 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2040
DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH
Sbjct: 1981 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2040
Query: 2041 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2100
ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN
Sbjct: 2041 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2100
Query: 2101 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL
Sbjct: 2101 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
Query: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS
Sbjct: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
Query: 2221 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2280
NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD
Sbjct: 2221 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2280
Query: 2281 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2340
LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN
Sbjct: 2281 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2340
Query: 2341 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400
ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS
Sbjct: 2341 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400
Query: 2401 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2460
QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL
Sbjct: 2401 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2460
Query: 2461 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2520
DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC
Sbjct: 2461 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2520
Query: 2521 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2580
ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES
Sbjct: 2521 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2580
Query: 2581 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2640
LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL
Sbjct: 2581 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2640
Query: 2641 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2700
QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR
Sbjct: 2641 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2700
Query: 2701 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2760
SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD
Sbjct: 2701 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2760
Query: 2761 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2820
QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA
Sbjct: 2761 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2820
Query: 2821 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2880
QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS
Sbjct: 2821 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2880
Query: 2881 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2940
SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW
Sbjct: 2881 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2940
Query: 2941 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 3000
EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE
Sbjct: 2941 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 3000
Query: 3001 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3060
EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ
Sbjct: 3001 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3060
Query: 3061 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3120
ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE
Sbjct: 3061 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3120
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI
Sbjct: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
Query: 3181 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3240
QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL
Sbjct: 3181 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3240
Query: 3241 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3300
KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ
Sbjct: 3241 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3300
Query: 3301 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3360
DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP
Sbjct: 3301 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3360
Query: 3361 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3420
EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN
Sbjct: 3361 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3420
Query: 3421 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3480
ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY
Sbjct: 3421 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3480
Query: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3540
RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR
Sbjct: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3540
Query: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600
DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF
Sbjct: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600
Query: 3601 NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRM 3660
NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRM
Sbjct: 3601 NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRM 3660
Query: 3661 GCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKI 3720
GCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKI
Sbjct: 3661 GCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKI 3720
Query: 3721 DKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHME 3780
DKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHME
Sbjct: 3721 DKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHME 3780
Query: 3781 QLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQ 3840
QLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQ
Sbjct: 3781 QLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQ 3840
Query: 3841 LSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMME 3900
LSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMME
Sbjct: 3841 LSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMME 3900
Query: 3901 EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL 3960
EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL
Sbjct: 3901 EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL 3960
Query: 3961 EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4020
EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD
Sbjct: 3961 EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLD 4020
Query: 4021 LLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ 4080
LLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ
Sbjct: 4021 LLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ 4080
Query: 4081 QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI 4140
QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI
Sbjct: 4081 QLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI 4140
Query: 4141 NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4200
NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST
Sbjct: 4141 NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAEST 4200
Query: 4201 AVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
AVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL
Sbjct: 4201 AVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC 4320
IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC
Sbjct: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC 4320
Query: 4321 SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKA 4380
SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKA
Sbjct: 4321 SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKA 4380
Query: 4381 LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4440
LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT
Sbjct: 4381 LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVT 4440
Query: 4441 GLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500
GLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF
Sbjct: 4441 GLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500
Query: 4501 DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP 4560
DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP
Sbjct: 4501 DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP 4560
Query: 4561 SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELE 4620
SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELE
Sbjct: 4561 SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELE 4620
Query: 4621 AQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK 4680
AQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK
Sbjct: 4621 AQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK 4680
Query: 4681 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA 4740
MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA
Sbjct: 4681 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA 4740
Query: 4741 EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSA 4800
EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSA
Sbjct: 4741 EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSA 4800
Query: 4801 IGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4860
IGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ
Sbjct: 4801 IGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4860
Query: 4861 EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4920
EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI
Sbjct: 4861 EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4920
Query: 4921 YSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEE 4980
YSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEE
Sbjct: 4921 YSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEE 4980
Query: 4981 LHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE 5040
LHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE
Sbjct: 4981 LHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE 5040
Query: 5041 EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEK 5100
EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEK
Sbjct: 5041 EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEK 5100
Query: 5101 TGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQ 5160
TGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQ
Sbjct: 5101 TGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQ 5160
Query: 5161 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5220
DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP
Sbjct: 5161 DKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP 5220
Query: 5221 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI 5280
PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI
Sbjct: 5221 PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI 5280
Query: 5281 EIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRD 5340
EIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRD
Sbjct: 5281 EIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRD 5340
Query: 5341 QIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG 5400
QIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG
Sbjct: 5341 QIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG 5400
Query: 5401 CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE 5460
CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE
Sbjct: 5401 CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE 5460
Query: 5461 YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQ 5520
YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQ
Sbjct: 5461 YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQ 5520
Query: 5521 YLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA 5580
YLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA
Sbjct: 5521 YLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA 5580
Query: 5581 QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 5640
QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA
Sbjct: 5581 QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 5640
Query: 5641 ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI 5700
ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI
Sbjct: 5641 ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI 5700
Query: 5701 QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL 5760
QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL
Sbjct: 5701 QELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL 5760
Query: 5761 DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDAS 5820
DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDAS
Sbjct: 5761 DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDAS 5820
Query: 5821 VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI 5880
VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI
Sbjct: 5821 VNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI 5880
Query: 5881 SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL 5940
SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL
Sbjct: 5881 SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL 5940
Query: 5941 MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK 6000
MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK
Sbjct: 5941 MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK 6000
Query: 6001 LNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV 6060
LNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV
Sbjct: 6001 LNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLV 6060
Query: 6061 EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ 6120
EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ
Sbjct: 6061 EIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ 6120
Query: 6121 GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSV 6180
GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSV
Sbjct: 6121 GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSV 6180
Query: 6181 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQK 6240
ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQK
Sbjct: 6181 ASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQK 6240
Query: 6241 LLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG 6300
LLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG
Sbjct: 6241 LLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG 6300
Query: 6301 AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSE 6360
AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSE
Sbjct: 6301 AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSE 6360
Query: 6361 EMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQN 6420
EMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQN
Sbjct: 6361 EMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQN 6420
Query: 6421 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ
Sbjct: 6421 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
Query: 6481 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 6540
VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG
Sbjct: 6481 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 6540
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 6600
DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS
Sbjct: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 6600
Query: 6601 AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL 6660
AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL
Sbjct: 6601 AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL 6660
Query: 6661 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6720
YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE
Sbjct: 6661 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6720
Query: 6721 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDA 6780
TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDA
Sbjct: 6721 TILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDA 6780
Query: 6781 QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP
Sbjct: 6781 QSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
Query: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 6900
SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN
Sbjct: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 6900
Query: 6901 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV
Sbjct: 6901 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 7020
QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN
Sbjct: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 7020
Query: 7021 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARY 7080
KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARY
Sbjct: 7021 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARY 7080
Query: 7081 SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN 7140
SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN
Sbjct: 7081 SLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTN 7140
Query: 7141 TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN 7200
TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN
Sbjct: 7141 TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN 7200
Query: 7201 KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 7260
KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ
Sbjct: 7201 KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQ 7260
Query: 7261 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 7320
HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE
Sbjct: 7261 HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQE 7320
Query: 7321 RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL 7380
RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL
Sbjct: 7321 RMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL 7380
Query: 7381 QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 7440
QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL
Sbjct: 7381 QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQIL 7440
Query: 7441 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 7500
HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM
Sbjct: 7441 HSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 7500
Query: 7501 AEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL 7560
AEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL
Sbjct: 7501 AEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL 7560
Query: 7561 LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 7620
LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT
Sbjct: 7561 LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 7620
Query: 7621 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 7680
FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN
Sbjct: 7621 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 7680
Query: 7681 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI 7740
ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI
Sbjct: 7681 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI 7740
Query: 7741 EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLD 7800
EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLD
Sbjct: 7741 EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLD 7800
Query: 7801 LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE 7860
LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE
Sbjct: 7801 LIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQE 7860
Query: 7861 LQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR 7920
LQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR
Sbjct: 7861 LQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERR 7920
Query: 7921 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 7980
LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE
Sbjct: 7921 LKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHE 7980
Query: 7981 CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 8040
CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE
Sbjct: 7981 CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 8040
Query: 8041 EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 8100
EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE
Sbjct: 8041 EFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 8100
Query: 8101 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 8160
QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED
Sbjct: 8101 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 8160
Query: 8161 SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8220
SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL
Sbjct: 8161 SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8220
Query: 8221 SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDH 8280
SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDH
Sbjct: 8221 SRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDH 8280
Query: 8281 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8340
SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK
Sbjct: 8281 SALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVK 8340
Query: 8341 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 8400
RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD
Sbjct: 8341 RLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSD 8400
Query: 8401 LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 8460
LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE
Sbjct: 8401 LNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPE 8460
Query: 8461 FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 8520
FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN
Sbjct: 8461 FTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 8520
Query: 8521 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC 8580
IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC
Sbjct: 8521 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC 8580
Query: 8581 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTS 8640
LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTS
Sbjct: 8581 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTS 8640
Query: 8641 GRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAA 8700
GRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAA
Sbjct: 8641 GRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAA 8700
Query: 8701 LPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8749
LPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL
Sbjct: 8701 LPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8749
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
[Homo sapiens]
Length = 8797
Score = 1.690e+04 bits (43856), Expect = 0.0
Identities = 8694/8827 (98%), Positives = 8704/8827 (98%), Gaps = 108/8827 (1%)
Query: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG
Sbjct: 1 MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDG 60
Query: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTD 120
VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRK IKLVNINSTD
Sbjct: 61 VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRK-------IKLVNINSTD 113
Query: 121 IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 180
IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT
Sbjct: 114 IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT 173
Query: 181 TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 240
TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR
Sbjct: 174 TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGR 233
Query: 241 SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 300
SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ
Sbjct: 234 SNRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQ 293
Query: 301 EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 360
EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH
Sbjct: 294 EDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH 353
Query: 361 FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 420
FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT
Sbjct: 354 FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 413
Query: 421 IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 480
IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN
Sbjct: 414 IGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVN 473
Query: 481 GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 540
GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR
Sbjct: 474 GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR 533
Query: 541 ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 600
ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ
Sbjct: 534 ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQ 593
Query: 601 WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 660
WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW
Sbjct: 594 WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 653
Query: 661 IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 720
IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY
Sbjct: 654 IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 713
Query: 721 TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 780
TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI
Sbjct: 714 TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 773
Query: 781 TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 840
TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK
Sbjct: 774 TKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGK 833
Query: 841 INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 900
INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD
Sbjct: 834 INEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD 893
Query: 901 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 960
QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK
Sbjct: 894 QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEK 953
Query: 961 GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1020
GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG
Sbjct: 954 GDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG 1013
Query: 1021 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1080
EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL
Sbjct: 1014 EAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL 1073
Query: 1081 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1140
CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF
Sbjct: 1074 CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRF 1133
Query: 1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1200
SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE
Sbjct: 1134 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1193
Query: 1201 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1260
VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK
Sbjct: 1194 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK 1253
Query: 1261 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1320
EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE
Sbjct: 1254 EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEE 1313
Query: 1321 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1380
LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE
Sbjct: 1314 LRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE 1373
Query: 1381 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1440
SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT
Sbjct: 1374 SLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT 1433
Query: 1441 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1500
LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI
Sbjct: 1434 LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEI 1493
Query: 1501 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1560
ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ
Sbjct: 1494 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQ 1553
Query: 1561 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1620
QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS
Sbjct: 1554 QQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS 1613
Query: 1621 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1680
ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER
Sbjct: 1614 ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLER 1673
Query: 1681 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1740
GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK
Sbjct: 1674 GEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVK 1733
Query: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800
MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE
Sbjct: 1734 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1793
Query: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1860
ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF
Sbjct: 1794 ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLF 1853
Query: 1861 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1920
EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL
Sbjct: 1854 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1913
Query: 1921 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1980
QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA
Sbjct: 1914 QNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA 1973
Query: 1981 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2040
DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH
Sbjct: 1974 DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEH 2033
Query: 2041 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2100
ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN
Sbjct: 2034 ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQN 2093
Query: 2101 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL
Sbjct: 2094 LKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2153
Query: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS
Sbjct: 2154 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2213
Query: 2221 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2280
NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD
Sbjct: 2214 NNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD 2273
Query: 2281 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2340
LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN
Sbjct: 2274 LQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN 2333
Query: 2341 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400
ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS
Sbjct: 2334 ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2393
Query: 2401 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2460
QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL
Sbjct: 2394 QLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNIL 2453
Query: 2461 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2520
DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC
Sbjct: 2454 DSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC 2513
Query: 2521 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2580
ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES
Sbjct: 2514 ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES 2573
Query: 2581 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2640
LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL
Sbjct: 2574 LDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEAL 2633
Query: 2641 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2700
QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR
Sbjct: 2634 QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR 2693
Query: 2701 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2760
SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD
Sbjct: 2694 SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD 2753
Query: 2761 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2820
QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA
Sbjct: 2754 QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTA 2813
Query: 2821 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2880
QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS
Sbjct: 2814 QEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS 2873
Query: 2881 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2940
SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW
Sbjct: 2874 SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQW 2933
Query: 2941 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 3000
EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE
Sbjct: 2934 EDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDE 2993
Query: 3001 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3060
EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ
Sbjct: 2994 EIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ 3053
Query: 3061 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3120
ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE
Sbjct: 3054 ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSE 3113
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI
Sbjct: 3114 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3173
Query: 3181 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3240
QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL
Sbjct: 3174 QMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL 3233
Query: 3241 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3300
KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ
Sbjct: 3234 KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQ 3293
Query: 3301 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3360
DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP
Sbjct: 3294 DWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP 3353
Query: 3361 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3420
EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN
Sbjct: 3354 EGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN 3413
Query: 3421 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3480
ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY
Sbjct: 3414 ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERY 3473
Query: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3540
RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR
Sbjct: 3474 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3533
Query: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600
DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF
Sbjct: 3534 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3593
Query: 3601 NNVVNKLRLMEQKFQQVDEWLKTAEEK----------------------KWHEEVTAYRD 3638
NNVVNKLRLMEQKFQQVDEWLKTAEEK KWHEEVTAYRD
Sbjct: 3594 NNVVNKLRLMEQKFQQVDEWLKTAEEKVSPRTRRQSNRATKEIQLHQMKKWHEEVTAYRD 3653
Query: 3639 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3698
EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS
Sbjct: 3654 EVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESS 3713
Query: 3699 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3758
LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER
Sbjct: 3714 LSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER 3773
Query: 3759 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3818
AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA
Sbjct: 3774 AVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIA 3833
Query: 3819 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV----------------R 3862
EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSV +
Sbjct: 3834 EYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLK 3893
Query: 3863 EKGEALLELVQDVTL--KDKIDQLQS---DYQDLCSI----------------------- 3894
+K + L QD+ K+ + L++ D++D S
Sbjct: 3894 DKIDQLQSDYQDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLET 3953
Query: 3895 ------------GKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGT 3942
KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGT
Sbjct: 3954 SSLETITQQLAHHKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGT 4013
Query: 3943 KDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAI 4002
KDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAI
Sbjct: 4014 KDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAI 4073
Query: 4003 KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWE 4062
KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWE
Sbjct: 4074 KQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWE 4133
Query: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTII 4122
EIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTII
Sbjct: 4134 EIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTII 4193
Query: 4123 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4182
EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL
Sbjct: 4194 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4253
Query: 4183 EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL 4242
EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL
Sbjct: 4254 EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKEL 4313
Query: 4243 VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302
VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ
Sbjct: 4314 VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4373
Query: 4303 SPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH 4362
SPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH
Sbjct: 4374 SPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSH 4433
Query: 4363 VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422
VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV
Sbjct: 4434 VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4493
Query: 4423 KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHR 4482
KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHR
Sbjct: 4494 KTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHR 4553
Query: 4483 LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSP 4542
LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSP
Sbjct: 4554 LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSP 4613
Query: 4543 EYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR 4602
EYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR
Sbjct: 4614 EYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR 4673
Query: 4603 KEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL 4662
KEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL
Sbjct: 4674 KEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDEL 4733
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ
Sbjct: 4734 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4793
Query: 4723 LKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4782
LKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK
Sbjct: 4794 LKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4853
Query: 4783 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL 4842
ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL
Sbjct: 4854 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL 4913
Query: 4843 DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL 4902
DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL
Sbjct: 4914 DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL 4973
Query: 4903 DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLK 4962
DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLK
Sbjct: 4974 DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLK 5033
Query: 4963 SHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQV 5022
SHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQV
Sbjct: 5034 SHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQV 5093
Query: 5023 DLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVN 5082
DLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVN
Sbjct: 5094 DLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVN 5153
Query: 5083 SFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW 5142
SFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW
Sbjct: 5154 SFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW 5213
Query: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5202
TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ
Sbjct: 5214 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5273
Query: 5203 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262
QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQIN
Sbjct: 5274 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5333
Query: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5322
SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP
Sbjct: 5334 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5393
Query: 5323 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5382
SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD
Sbjct: 5394 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5453
Query: 5383 NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIR 5442
NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIR
Sbjct: 5454 NVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIR 5513
Query: 5443 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5502
QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL
Sbjct: 5514 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5573
Query: 5503 EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD 5562
EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD
Sbjct: 5574 EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKD 5633
Query: 5563 MKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ 5622
MKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ
Sbjct: 5634 MKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQ 5693
Query: 5623 SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQL 5682
SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQL
Sbjct: 5694 SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQL 5753
Query: 5683 IEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT 5742
IEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT
Sbjct: 5754 IEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHAT 5813
Query: 5743 MLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI 5802
MLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI
Sbjct: 5814 MLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI 5873
Query: 5803 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSA 5862
SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSA
Sbjct: 5874 SSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSA 5933
Query: 5863 TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG 5922
TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG
Sbjct: 5934 TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG 5993
Query: 5923 RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAER 5982
RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAER
Sbjct: 5994 RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAER 6053
Query: 5983 MSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP 6042
MSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP
Sbjct: 6054 MSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP 6113
Query: 6043 KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLK 6102
KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLK
Sbjct: 6114 KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLK 6173
Query: 6103 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ 6162
GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ
Sbjct: 6174 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ 6233
Query: 6163 QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED 6222
QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED
Sbjct: 6234 QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED 6293
Query: 6223 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTS 6282
QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTS
Sbjct: 6294 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTS 6353
Query: 6283 LLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETE 6342
LLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETE
Sbjct: 6354 LLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETE 6413
Query: 6343 TCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVN 6402
TCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVN
Sbjct: 6414 TCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVN 6473
Query: 6403 QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6462
QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL
Sbjct: 6474 QRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6533
Query: 6463 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER 6522
KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER
Sbjct: 6534 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER 6593
Query: 6523 ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIIS 6582
ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIIS
Sbjct: 6594 ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIIS 6653
Query: 6583 FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP 6642
FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP
Sbjct: 6654 FAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP 6713
Query: 6643 SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLG 6702
SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLG
Sbjct: 6714 SVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLG 6773
Query: 6703 ECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE 6762
ECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE
Sbjct: 6774 ECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELE 6833
Query: 6763 MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLT 6822
MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLT
Sbjct: 6834 MVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLT 6893
Query: 6823 NIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKY 6882
NIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKY
Sbjct: 6894 NIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKY 6953
Query: 6883 KGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK 6942
KGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK
Sbjct: 6954 KGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEK 7013
Query: 6943 IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKA 7002
IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKA
Sbjct: 7014 IQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKA 7073
Query: 7003 KEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS 7062
KEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS
Sbjct: 7074 KEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWS 7133
Query: 7063 SHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI 7122
SHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI
Sbjct: 7134 SHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI 7193
Query: 7123 TNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS 7182
TNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS
Sbjct: 7194 TNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAS 7253
Query: 7183 TVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ 7242
TVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ
Sbjct: 7254 TVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQ 7313
Query: 7243 VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEE 7302
VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEE
Sbjct: 7314 VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEE 7373
Query: 7303 ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL 7362
ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL
Sbjct: 7374 ILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL 7433
Query: 7363 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ 7422
NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ
Sbjct: 7434 NRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ 7493
Query: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQ 7482
QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQ
Sbjct: 7494 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQ 7553
Query: 7483 RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 7542
RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV
Sbjct: 7554 RRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 7613
Query: 7543 FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 7602
FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK
Sbjct: 7614 FLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 7673
Query: 7603 DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7662
DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL
Sbjct: 7674 DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7733
Query: 7663 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7722
LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC
Sbjct: 7734 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7793
Query: 7723 EWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKAS 7782
EWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKAS
Sbjct: 7794 EWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKAS 7853
Query: 7783 EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 7842
EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV
Sbjct: 7854 EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 7913
Query: 7843 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 7902
YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT
Sbjct: 7914 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 7973
Query: 7903 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 7962
RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT
Sbjct: 7974 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 8033
Query: 7963 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ 8022
VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ
Sbjct: 8034 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ 8093
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ
Sbjct: 8094 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8153
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRL 8142
QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRL
Sbjct: 8154 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRL 8213
Query: 8143 PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 8202
PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD
Sbjct: 8214 PLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRD 8273
Query: 8203 TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESP 8262
TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL
Sbjct: 8274 TPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL--------- 8324
Query: 8263 EAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSY 8322
SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSY
Sbjct: 8325 --------------SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSY 8370
Query: 8323 KGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALS 8382
KGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALS
Sbjct: 8371 KGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALS 8430
Query: 8383 KELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK 8442
KELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK
Sbjct: 8431 KELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQK 8490
Query: 8443 AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 8502
AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM
Sbjct: 8491 AVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALM 8550
Query: 8503 QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8562
QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA
Sbjct: 8551 QCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVA 8610
Query: 8563 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 8622
SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS
Sbjct: 8611 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLS 8670
Query: 8623 SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSE 8682
SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSE
Sbjct: 8671 SWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSE 8730
Query: 8683 PGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRY 8742
PGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRY
Sbjct: 8731 PGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRY 8790
Query: 8743 TNGPPPL 8749
TNGPPPL
Sbjct: 8791 TNGPPPL 8797
>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
[Homo sapiens]
Length = 3321
Score = 6468 bits (16780), Expect = 0.0
Identities = 3321/3344 (99%), Positives = 3321/3344 (99%), Gaps = 23/3344 (0%)
Query: 5406 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 5465
MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML
Sbjct: 1 MELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
Query: 5466 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 5525
ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV
Sbjct: 61 ELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSV 120
Query: 5526 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT
Sbjct: 121 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 180
Query: 5586 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 5645
SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ
Sbjct: 181 SPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQ 240
Query: 5646 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 5705
EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA
Sbjct: 241 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQA 300
Query: 5706 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 5765
QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL
Sbjct: 301 QISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELL 360
Query: 5766 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 5825
PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI
Sbjct: 361 PTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDI 420
Query: 5826 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 5885
AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR
Sbjct: 421 AYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQR 480
Query: 5886 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 5945
TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE
Sbjct: 481 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDE 540
Query: 5946 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 6005
INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL
Sbjct: 541 INELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQL 600
Query: 6006 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 6065
EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK
Sbjct: 601 EEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQK 660
Query: 6066 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 6125
VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE
Sbjct: 661 VVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE 720
Query: 6126 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 6185
KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE
Sbjct: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGE 780
Query: 6186 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 6245
EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV
Sbjct: 781 EILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNV 840
Query: 6246 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 6305
LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS
Sbjct: 841 LEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS 900
Query: 6306 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 6365
IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN
Sbjct: 901 IHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKN 960
Query: 6366 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 6425
KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL
Sbjct: 961 KNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVL 1020
Query: 6426 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 6485
FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS
Sbjct: 1021 FTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPS 1080
Query: 6486 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 6545
MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII
Sbjct: 1081 MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKII 1140
Query: 6546 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 6605
VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR
Sbjct: 1141 VSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKR 1200
Query: 6606 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665
AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK
Sbjct: 1201 AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 1260
Query: 6666 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 6725
SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH
Sbjct: 1261 SSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKH 1320
Query: 6726 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6785
WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK
Sbjct: 1321 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 1380
Query: 6786 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6845
SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI
Sbjct: 1381 SSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 1440
Query: 6846 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 6905
SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ
Sbjct: 1441 SEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQ 1500
Query: 6906 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 6965
ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT
Sbjct: 1501 ISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKT 1560
Query: 6966 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 7025
WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV
Sbjct: 1561 WFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDV 1620
Query: 7026 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 7085
SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF
Sbjct: 1621 SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF 1680
Query: 7086 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 7145
RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV
Sbjct: 1681 RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEV 1740
Query: 7146 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 7205
NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD
Sbjct: 1741 NMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD 1800
Query: 7206 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 7265
DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL
Sbjct: 1801 DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCAL 1860
Query: 7266 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 7325
EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL
Sbjct: 1861 EQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEEL 1920
Query: 7326 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 7385
KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL
Sbjct: 1921 KGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLL 1980
Query: 7386 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7445
QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII
Sbjct: 1981 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 2040
Query: 7446 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7505
DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR
Sbjct: 2041 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 2100
Query: 7506 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7565
KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD
Sbjct: 2101 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 2160
Query: 7566 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 7625
SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL
Sbjct: 2161 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKL 2220
Query: 7626 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 7685
SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL
Sbjct: 2221 SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVEL 2280
Query: 7686 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 7745
LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE
Sbjct: 2281 LQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE 2340
Query: 7746 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7805
KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR
Sbjct: 2341 KLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 2400
Query: 7806 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 7865
VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI
Sbjct: 2401 VKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDI 2460
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE
Sbjct: 2461 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 2520
Query: 7926 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 7985
TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL
Sbjct: 2521 TWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 2580
Query: 7986 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 8045
ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA
Sbjct: 2581 ELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETA 2640
Query: 8046 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 8105
RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK
Sbjct: 2641 RDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEK 2700
Query: 8106 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 8165
SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS
Sbjct: 2701 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALS 2760
Query: 8166 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 8225
DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE
Sbjct: 2761 DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE 2820
Query: 8226 SAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALES 8285
SAMSRALPSEDEEGQDDKDFYLRGAVGL SGDHSALES
Sbjct: 2821 SAMSRALPSEDEEGQDDKDFYLRGAVGL-----------------------SGDHSALES 2857
Query: 8286 QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 8345
QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK
Sbjct: 2858 QIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHK 2917
Query: 8346 LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 8405
LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW
Sbjct: 2918 LKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW 2977
Query: 8406 AWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 8465
AWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD
Sbjct: 2978 AWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 3037
Query: 8466 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 8525
SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK
Sbjct: 3038 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 3097
Query: 8526 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKE 8585
NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKE
Sbjct: 3098 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKE 3157
Query: 8586 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTP 8645
KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTP
Sbjct: 3158 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTP 3217
Query: 8646 NRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQL 8705
NRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQL
Sbjct: 3218 NRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQL 3277
Query: 8706 LLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 8749
LLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL
Sbjct: 3278 LLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPPL 3321
Score = 181 bits (460), Expect = 2e-44
Identities = 473/2685 (17%), Positives = 1039/2685 (38%), Gaps = 344/2685 (12%)
Query: 1249 KNSLEELISGSKEVQEQAEKILDTEN-LFEAQQ-------LLLHHQQKTKRISAKKRDVQ 1300
K +L+ +S KE + +++D +N L E +Q L +H++ A +D
Sbjct: 627 KATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEA 686
Query: 1301 QQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFE-----TN 1355
+Q+A +LR+L+ +L L+R+ ++ +Q T ++ E + T
Sbjct: 687 EQLAG--------------KLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQ 732
Query: 1356 KETVVRYLFQ--TGSSHERFLSFSSLESLSSELEQTKEF----SKRTESIAVQ--AENLV 1407
V +L Q T + +R S + L EL + K + R E I +Q A
Sbjct: 733 SPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETS 792
Query: 1408 KEASEIPLGPQNKQLLQQQAKSIKEQV---------------KKLEDTLEE--------- 1443
+A E P + ++ + S ++Q+ K L++ LE+
Sbjct: 793 GDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSR 852
Query: 1444 -------------DIKTMEM--VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDM 1488
D+ T + V + D FE +S +++ LE +
Sbjct: 853 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQK---LYD 909
Query: 1489 QISQIKVTIQEIESKL---SSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEEL-- 1543
+S + ++E +L ++++ E E F Q + + + ++ + + +
Sbjct: 910 GVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFP 969
Query: 1544 -----REHAQCLEGTILGHLSQ-----QQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
R+ + G +LG LS Q+ + ++QQ + F++ L V S A
Sbjct: 970 ENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQ-ILNFQNDLKV--LFTSLAD 1026
Query: 1594 ETYKVLQEHMDL--------CQALESLSSAITAFSASARKVVNRDS-------CVQEAAA 1638
Y +LQ+ ++ +A++ + F A ++ R +QE +
Sbjct: 1027 NKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK 1086
Query: 1639 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1698
LQ Y++++ R++ L L + E+ L LE G+ K + + I + + +
Sbjct: 1087 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 1146
Query: 1699 VEGEL----QLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWR 1754
++ L + Q L++ ++ + + K++ F+V K + H E + +
Sbjct: 1147 IQQLLDKHKEYFQGLESHMILTETLFRKIIS-----FAVQ-----KETQFHTELMAQASA 1196
Query: 1755 DLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHK 1814
L + +KR L+ ++ DE S +++ S + + + + ++
Sbjct: 1197 VLKRA-HKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLI----- 1250
Query: 1815 DHAAEVESKKGELQSLQGHLAKLGSLGR-------AEDLHLLQGKAEDCF-QLFEEASQV 1866
D + K L Q L ++ G+ DL + +C+ + S+
Sbjct: 1251 DRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKE 1310
Query: 1867 VERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMN---KNESDLIEKDLNDALQNA 1923
+ R + L H + A L L+ + +E + E +++ LN L+ +
Sbjct: 1311 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 1370
Query: 1924 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADAL 1983
K +++ + +LS L++ + T R+ ++ + + + Q + L
Sbjct: 1371 KEVDAQSSLKSSVLSTGNQLLRLKKVDTAT-LRSELSRIDSQWTDLLTNIPAVQEKLHQL 1429
Query: 1984 AVLKKAFQDQKEELLKSIEDIEE--RTDKERLKEPTR-QALQQRLRVFNQLEDELNSHEH 2040
+ K + E++ I +E + D++ +K +A+ + L+ + + ++N +
Sbjct: 1430 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQL 1489
Query: 2041 ELCWLKDKAKQIAQKDV----AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMR 2096
+ ++ QI+ +DV + + ++ + +W + L+ E GL++
Sbjct: 1490 TVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWS 1549
Query: 2097 EYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKG 2156
EY+N + E + + I DQ ++ A + ++ + K+K+++ G
Sbjct: 1550 EYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG 1609
Query: 2157 KHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEI 2216
L+ K+ SS +V + + W ++ + + L+ L W D+I
Sbjct: 1610 LALIQNKKEDVSS---IVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 1666
Query: 2217 EGW----------------SNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEE 2260
+ S V +N+ NL + L +E + + N+ L+ E
Sbjct: 1667 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK--E 1724
Query: 2261 LHSKV-----NDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQ 2315
H V N LKE+ + ++ ++L+ +K + ++ + KD++ Q
Sbjct: 1725 CHPPVTETLTNTLKEVNMRWNN------LLEEIAEQLQSSKALLQLWQ-RYKDYSKQCAS 1777
Query: 2316 VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCR 2375
+ D T K + + A +E ++ D+ K L + + ++ E L +
Sbjct: 1778 TVQQQEDRTNELLKAATN-KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQ 1836
Query: 2376 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKH--FSESMQEFQEWFLGAK 2433
+ ++ ++ L + A+ Q K Q SLQ + + F++S++ + W + A+
Sbjct: 1837 QVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE 1896
Query: 2434 AAAK-ESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIV--- 2489
+ + + D ++ ++ +L+ + S LD + + G L + K+I
Sbjct: 1897 EILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLN-DKEIKRMQ 1955
Query: 2490 ------SSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEE 2543
S I Q T+ + Q+FL L+ + L+ C + + +KL +
Sbjct: 1956 NLNRHWSLISSQTTERFSKLQSFL---LQHQTFLEKCETWMEFLVQTEQKLAV------- 2005
Query: 2544 RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQ-EG 2602
+ + QH+ E++ H E+F E+ + ++ L + GQ L E+G + E
Sbjct: 2006 -----EISGNYQHLLEQQR-AH--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 2057
Query: 2603 RLCSQLLTSH-QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ----DRLACA 2657
L LL++ Q ++R +++ +++ + E + + W+ + L
Sbjct: 2058 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV 2117
Query: 2658 ESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETL 2717
L TL + Q ++ + ++ +G L + GK Q L S++ + +Q +L +
Sbjct: 2118 PIPLQQARTLFDEV-QFKEKVFLRQQGSYILTVEAGK--QLLLSADSGAEAALQAELAEI 2174
Query: 2718 KEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQ-PGLKEK 2776
+E W + L ++ W + + + + +K+ L L +
Sbjct: 2175 QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAE 2234
Query: 2777 FVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAK 2836
+ L++ + D L L+ + Y +D S + E L+ Q+ ++
Sbjct: 2235 QMRCKELENAVGSWTDDLTQLS-LLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 2293
Query: 2837 EKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDS 2896
+ +++ E + + ++ + E +WL + ++ + D+ + + K +E+ +
Sbjct: 2294 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 2353
Query: 2897 REIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVS 2956
+E E LA + + AS E ++ + W+ L +L++
Sbjct: 2354 QENKIQLQQMGERLA-KASHESKASEIEY---KLGKVNDRWQH-----------LLDLIA 2398
Query: 2957 QMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT------LLEGKNTDEEIVECWHKGQ 3010
+E V QL++ + L+TW + ++ EEI ++ Q
Sbjct: 2399 ARVKKLKETLVAVQQLDKNMSS----LRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQ 2454
Query: 3011 EILDALQKAEPRTEDLKSQLN---------ELCRFSRDLSTYSGKVSGLIKEYNCLCLQA 3061
E+ ++K + + S LN + C + + L + + +C +
Sbjct: 2455 ELQRDIEK---HSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMS 2511
Query: 3062 SKGCQNKEQI--LQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLS 3119
+ E+ L Q+F + F+ WL +++ T A + L+K + F
Sbjct: 2512 MERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 2571
Query: 3120 ESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLK 3179
+ +L ++ + L+ + A ++ V + W N + L++
Sbjct: 2572 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFI 2631
Query: 3180 IQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLN 3238
Q ++FE + + I WL++ + ++ + D+ AK ++ + Q +EI ++
Sbjct: 2632 GQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ---QEISLNHNKIE 2688
Query: 3239 RLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3296
++ + +QL E + + +L + + +L R+ ++ L
Sbjct: 2689 QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 2748
Query: 3297 KELQDWMTDAIHMLDSYCHPTSDKSVLDSR-TLKLEALLSVKQEKEIQMKMIVTRGESV- 3354
+EL+ + D+ + D + H S S+L + + L L+ E + +S+
Sbjct: 2749 RELE--LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIP 2806
Query: 3355 ------------LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQ 3402
L++ +P+ ++ Q KD + +R L G S + +
Sbjct: 2807 LEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY-------LRGAVGLSGDHS---ALE 2856
Query: 3403 DGVRQFSGWMDSMEANLNESERQHAELRDKT--------TMLGKAKLLNEEVLSYSSL-- 3452
+RQ +D + ++E +R KT + G KLL E S S+
Sbjct: 2857 SQIRQLGKALDDSRFQIQQTENI---IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKR 2913
Query: 3453 ----LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDL 3508
L+ E G + T+ + + +R+ +Q +A + ++ ++ Q++ DL
Sbjct: 2914 LEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDL 2973
Query: 3509 KAFEVWLGQEQEKLDQYSVLE--GDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDV 3566
+ WLG +E+L+Q LE D T E ++ L+ELQ +A++ S+ +
Sbjct: 2974 NSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF 3033
Query: 3567 IPSGIPQA---EDRALE---------SLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKF 3614
+ ++ +DR + SL ++W+ F+ + + L LM +
Sbjct: 3034 TQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENI 3093
Query: 3615 QQ-------VDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDES---HVNSR-MGCQ 3663
+ +D L + H+++ + E+ E R + D S VN+ C
Sbjct: 3094 DRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCL 3153
Query: 3664 ATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYS 3703
+ + +R + LL +V IK L E++ + S+ LSS+S
Sbjct: 3154 EAKEKVHVIGNRLKLLLKEVSRHIKEL-EKLLDVSSSQQDLSSWS 3197
Score = 179 bits (453), Expect = 1e-43
Identities = 583/3369 (17%), Positives = 1254/3369 (37%), Gaps = 426/3369 (12%)
Query: 1177 IRNGVTKRGETLSWLKSRLKVLTEV------SSENEAQKQGDELAKLSSSFKALVTLLSE 1230
++ + + G+ L ++ LTE+ +EN K + L + L +L
Sbjct: 7 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 66
Query: 1231 VEKMLSNFGDCVQYKEIVKNSLEEL----------ISGSKEVQEQAEKILDTENLFEAQQ 1280
+EK + + I NS +L + SKE+ + E + + +
Sbjct: 67 IEK-----AKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 121
Query: 1281 LLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQER 1340
Q+ + + +++Q I Q L D ++++K E+ L L+ + E+
Sbjct: 122 CTEKMSQQVAELGRETEELRQMIKIRLQN---LQDAA-KDMKKFEAELKKLQAALEQA-- 175
Query: 1341 RIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIA 1400
Q TL E V R + SH + L S +ESL +
Sbjct: 176 --QATLTSPE--------VGRLSLKEQLSHRQHL-LSEMESLKPK--------------- 209
Query: 1401 VQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGS 1460
VQA L + A IP L A ++E+ +L+ T + M+ +++ +
Sbjct: 210 VQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 269
Query: 1461 NFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSF--- 1517
+ L I +E+ ++S I +++ I E I G +E+ S
Sbjct: 270 EMKHLQQLIEGAHREIEDKPVATS----NIQELQAQISRHEELAQKIKGYQEQIASLNSK 325
Query: 1518 -AQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTIL----GHLSQQQKFEENLRKIQ 1572
+ A + +T++ E L E + L+G +L H S +
Sbjct: 326 CKMLTMKAKHATMLLTVTEV----EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLL 381
Query: 1573 QSVSEFEDKLAVPIKICSS--------ATETYKVLQEHMDLCQALES----LSSAITAFS 1620
V+E + +I S T + + + QAL + +A S
Sbjct: 382 SPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPS 441
Query: 1621 ASARKVVNRDSCVQEAAA----LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1676
SA + A A LQ+ +E + E+Q L L Q+ + L S T
Sbjct: 442 TSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIST 501
Query: 1677 WLERGEAKAS-------SPEMDISADRVKVEGEL-------QLIQALQNEVVS------- 1715
+E E K S SPE ++ + ++ L +L +L E+VS
Sbjct: 502 KMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADP 561
Query: 1716 --QASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1773
Q + S L L E + ++ K K L E+L+++ + ++ LQ E
Sbjct: 562 AEQLALQSTLTVLAERMSTIRMKASGKRQLLE-EKLNDQLEE-----QRQEQALQRYRCE 615
Query: 1774 HQQFDELLLSFSVWIKLFLS------------------------ELQTTSEISIMDHQVA 1809
+ D LLS + LS ++ SE+S+ + +
Sbjct: 616 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL 675
Query: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQ----------- 1858
L E E G+L+ L+G L +L + L++ QG A++ +
Sbjct: 676 LEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSP 734
Query: 1859 -----LFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEAT---NSMNKNESD 1910
L + + ++RQ +L E Q A +LR + E +S + D
Sbjct: 735 GVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGD 794
Query: 1911 LIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQ 1970
EK D L +E S + Q +K S Q S + Q E E+ Q
Sbjct: 795 AGEKP--DVLSQELGMEGEKSSAED-----QMRMKWESLHQEFSTKQKLLQNVLEQEQEQ 847
Query: 1971 NLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQ 2030
L + + K Q + + S+ D + +E + + A +Q + + +
Sbjct: 848 VLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEE-VSSQSGGAKRQSIHLEQK 906
Query: 2031 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCG 2090
L D +++ WL D +++ E + + E+ D K + E
Sbjct: 907 LYDGVSATS---TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEE------- 956
Query: 2091 LIDLMREYQNLKSAV-------SKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMN 2143
M + +NL S V+E+ ++ R ++ D + E + +N
Sbjct: 957 ----MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN 1012
Query: 2144 YKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSE------KLEENMD 2197
++ FTS + L+K+ + V +E+ + E +L+ D
Sbjct: 1013 FQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGD 1072
Query: 2198 RLRV---SLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNK 2254
+L+V S+ + DE+ + + +N++ + RA + L + + K
Sbjct: 1073 KLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEK 1132
Query: 2255 AL--------RLEELHSKVNDLKELTKNLETPPDL------QFIEADLMQKLEHAKEITE 2300
EE+ ++ KE + LE+ L + I + ++ + E+
Sbjct: 1133 MAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMA 1192
Query: 2301 VAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQ 2360
A LK + ++E + TW E+ Q E E+ + +E + +
Sbjct: 1193 QASAVLKRAHKRGVELEYILE---TWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL 1249
Query: 2361 SNISSTQENLNSLCRKYHSAELESL--GRAMTGLIKKHEAVSQLCSKTQASLQ------- 2411
+ + ++L S +Y + L G+ + I + SQL + L
Sbjct: 1250 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSK 1309
Query: 2412 -----ESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDG 2466
E++ KH++ E + ++A T S + +L +++ L++ +
Sbjct: 1310 ELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEF 1369
Query: 2467 QSKLDA-------VTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2519
++DA V G L L K ++++ ++++ + ++ L ++ L
Sbjct: 1370 SKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 1428
Query: 2520 CASELGSFEDQHRKLNLWIHEME-----ERFNTEN-LGESKQHIPEKKNEVHKVEMFLGE 2573
+ ++ WI ME + N +N +G H +K + K+++ +
Sbjct: 1429 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQ 1488
Query: 2574 LLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
L + L Q + + + S Q L + EK++ + L+
Sbjct: 1489 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 1548
Query: 2634 EALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIG 2693
E +Q + W + + RL + +G + +++ L QD+ + E ++
Sbjct: 1549 SEYENNVQCLKTWFETQEKRLK-QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 1607
Query: 2694 KGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLE 2753
G +++ ++ ++ + L L + WA++ + L+SV+ QW+ + +++
Sbjct: 1608 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 1667
Query: 2754 QWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTED 2813
++ + L+ V +D+LQ++ + E R+L + + + +L ++
Sbjct: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 1727
Query: 2814 ---ESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
E+ +T +E + ++N+++ E+++ + +++ Y D + + ++
Sbjct: 1728 PVTETLTNTLKE-VNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 1786
Query: 2871 HRW------SDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCE 2924
+ D++ D AT + +L+ L + L ++KQ AS
Sbjct: 1787 NELLKAATNKDIADDEVATW--IQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 1844
Query: 2925 LMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLK 2984
+ ++ +L Q LE AL +Q+ S Q L+ +
Sbjct: 1845 AIQSDQLSLS-----------QHLCALEQ-----ALCKQQTSLQAGVLDY---------E 1879
Query: 2985 TWAQQLTLLEGKNTD-EEIVECWHKGQEILDA--LQKAEPRTEDLKSQLNELCRFSRDLS 3041
T+A+ L LE + EEI++ GQ+ + L + R E+LK Q+ + + DL
Sbjct: 1880 TFAKSLEALEAWIVEAEEILQ----GQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLD 1935
Query: 3042 TYSG-------------KVSGLIKEYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQW 3086
+ ++ L + ++ + Q ++ + L Q F + + ++
Sbjct: 1936 RLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEF 1995
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEK 3146
LV + A +I N + + + F +E + Q L+ ++ G+ L +
Sbjct: 1996 LVQTEQKLA--VEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDD 2053
Query: 3147 AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHES 3206
K+T W+ Q+ +++ Q + + AE ++ WL V S
Sbjct: 2054 RDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL------VEVS 2107
Query: 3207 SNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLK-------EKAQQLW--EGQAASKSF 3257
+ L + Q+ +++ +E+ E R + E +QL A +
Sbjct: 2108 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAAL 2167
Query: 3258 RHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKE-LQDWMTDAIHMLDSYCHP 3316
+ ++++ ++ + S +E+ +L ++ + + GI + L+ T + S
Sbjct: 2168 QAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 2227
Query: 3317 TSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDM 3376
+ R +LE + + Q+ ++ +++ S + I + ++++ ++
Sbjct: 2228 HEELHAEQMRCKELENAVGSWTDDLTQLSLLK---DTLSAYISADDISILNERVELLQRQ 2284
Query: 3377 WASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNES-----ERQHAELRD 3431
W L + Q+ L++W + + ++ W+ ME+ ++++ E +L
Sbjct: 2285 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKL-- 2342
Query: 3432 KTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAV 3491
K + + E + + E + K + ++ + +L + +R++ + + V
Sbjct: 2343 KKDYQEEIAIAQENKIQLQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARV 2401
Query: 3492 TKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEG-DAHTHETTLRDLQELQVHCA 3550
K ++ + Q+ +++ + WL + +L + V + ++ + L + QELQ
Sbjct: 2402 KKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 2461
Query: 3551 EGQALLNSVLHTREDVIPSGIPQAEDRALESLRQD-------WQAYQHRLSETRTQFNNV 3603
+ + SVL+ E ++ A D +S++Q W+ E R +
Sbjct: 2462 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 2521
Query: 3604 VNKLRLMEQKFQQVDEWLKTAEE---------------KKWHEEVTAYRDEVEE------ 3642
+ + + ++WLK++E K+ ++ A++ +V E
Sbjct: 2522 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLE 2581
Query: 3643 -VGARAQEILDESHVNSRMGCQATQLT----SRYQALLLQVLEQIKFLEEEIQSLEESES 3697
+ + + + E+ +S C Q+ R+ L +V ++ L+ I EE E+
Sbjct: 2582 LINKQYRRLARENRTDS--ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 2639
Query: 3698 SLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGE 3757
+ S W N I+ + K+K L+ +++ H+ ++ +GE
Sbjct: 2640 ARDSILVWLTEMDLQLTN----IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGE 2695
Query: 3758 RAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWI 3817
+ ++ E +A + +E+ + +E+ V + H L + E + L
Sbjct: 2696 QLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 2755
Query: 3818 AEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTL 3877
+ LH + L + + SL Q + S + LE D L
Sbjct: 2756 SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 2815
Query: 3878 KDKIDQLQSDYQDLCSIGKAM-MEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVH 3936
++ S +A+ E+ G +D+ + ++G +G DH + L+ +
Sbjct: 2816 SRDLESAMS---------RALPSEDEEGQDDK--DFYLRG--AVGLSGDH--SALESQIR 2860
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPL 3996
+ DS I T +++ R T P+L+ S + +
Sbjct: 2861 QLGKALDDSRFQIQQT-------------ENIIRSKT---------PTGPELDTSYKGYM 2898
Query: 3997 S-RAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTE----QTIEQKL 4051
E + + L+ + + + L +L + + TA I + E Q + ++L
Sbjct: 2899 KLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ-TAGVIDRWELLQAQALSKEL 2957
Query: 4052 VQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKL 4111
QNL Q W++ + +W +L D +++L+ ++R ++ + + ++K+ K +
Sbjct: 2958 RMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 3016
Query: 4112 QSKQA---SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRT 4168
++A S+N + + KE ++ +N +W +C ++ L +
Sbjct: 3017 DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC 3076
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNL----ARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ +H+ + + + LE + + + DAE H + L ++ L E + + L
Sbjct: 3077 QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASL 3136
Query: 4225 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQE 4284
+D +++ + D KE+ + R L+ +++ + LE+L V S Q+
Sbjct: 3137 QDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----KLLLKEVSRHIKELEKLLDVSSSQQD 3192
Query: 4285 LMEWAEEQQ 4293
L W+ +
Sbjct: 3193 LSSWSSADE 3201
Score = 171 bits (434), Expect = 2e-41
Identities = 594/3328 (17%), Positives = 1269/3328 (38%), Gaps = 427/3328 (12%)
Query: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
A+V +E+ +L K P K+I L + RQ+ N + + +Y++ +
Sbjct: 5 AAVQKFLEQNGQLGK----PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML 60
Query: 4176 NVVEVFLEKF------TTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQ 4229
++ ++EK T W N A E +H L+E K +L+ +
Sbjct: 61 ELILKWIEKAKVLAHGTIAW-NSASQLREQYILH-------QTLLEESKEIDSELEAMTE 112
Query: 4230 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4289
K+ ++ E + +Q + L + +L +IK ++Q +++ ++ ++L
Sbjct: 113 KLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAAL 172
Query: 4290 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4349
E+ Q + P++ + L + L+ L ++ LK ++ + L + E
Sbjct: 173 EQAQATLTS-------PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPED 225
Query: 4350 QVIQKALSDA----QSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI 4405
V L A Q + L Q+ + A+ + Q+ + I+ R+I
Sbjct: 226 VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI 285
Query: 4406 MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL---------WAQGRELMKEVTEQ 4456
+ ++ Q+ + +K YQ ++ L A+ ++ VTE
Sbjct: 286 EDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 345
Query: 4457 E-----KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD 4511
E ++ G+L S + SV+ + R L + +E ++ + +
Sbjct: 346 EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT-----EESGEEGTNSEISSP 400
Query: 4512 IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSY-- 4569
+ N + ++ +A YQ + + LQ I PS + Y
Sbjct: 401 PACRSPSPVANTDASVNQDIAYYQALSAE---------RLQTDAAKIHPSTSASQEFYEP 451
Query: 4570 -----LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLS-ELEAQF 4623
+ KL L R + + + +K + EA+ +++Y + QS+S ++EA
Sbjct: 452 GLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD----SLQSISTKMEAIE 507
Query: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQK-KEGFRSTGQPWQPDKML 4682
L++S+ P E+ + +A++DE+ L + ++EL E S P + L
Sbjct: 508 LKLSESPEPGRSPESQMAEH--QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 565
Query: 4683 HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEE 4742
L + L +R+S + S + Q LE +L EEQ + E+
Sbjct: 566 ALQSTLTVL----AERMSTIRMKASGKR------QLLEEKLNDQLEEQRQ--------EQ 607
Query: 4743 KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4802
L+ Y A L DS ++ + T+ L+P +P+ E Q+ E++ A+
Sbjct: 608 ALQRYRCEADEL-DSWLLSTKATLDTA-LSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 665
Query: 4803 ETVTECESRMVQ-SIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQE 4861
E E+ +++ + E + LRR+K L L+L +++ QE
Sbjct: 666 ELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSL-----LELQRALHDKQLNMQGTAQE 720
Query: 4862 EVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIY 4921
+ +S + + S +E +A+ + + SL + EL+ ++ E +++ L +
Sbjct: 721 KEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE----QKSLLRSVA 776
Query: 4922 SQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEEL 4981
S+ + AA E AG DV S E ++ E S EDQ E L
Sbjct: 777 SRGEEILIQHSAA--------ETSGDAGEKPDVLSQELGMEG--EKSSAEDQMRMKWESL 826
Query: 4982 HSLVATLDPLIKPTGKEDLEQKVASLELR---------SQRMSRDSGAQVDLLQRCTAQW 5032
H +T L++ +++ EQ + S R ++D A LL +
Sbjct: 827 HQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAF 886
Query: 5033 HDYQK----AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS---FH 5085
+ A+ + I L E+KL + ++ + EE+L AL+ F+
Sbjct: 887 EEVSSQSGGAKRQSIHL----EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFN 942
Query: 5086 EKIVA--LEEKASQLEKTGNDASKA---------TLSRSMTTVWQRWTRLRAVAQDQEKI 5134
++I+A ++E + +++K N S+A + ++ + R + L +V +
Sbjct: 943 QEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQ 1002
Query: 5135 LEDAVDEWTGFNNKVKKA-TEMIDQ----LQDKLPGSSAEKASKAELLTL----LEYHDT 5185
+++ + + F N +K T + D LQ A + E + L+ D
Sbjct: 1003 MKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 1062
Query: 5186 FVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245
++EL+++ L + E P MQE++ +QD + + +
Sbjct: 1063 GIIELKRRGDKLQV-------------------EQPSMQELSKLQDMYDELMMIIGSRRS 1103
Query: 5246 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK 5305
+ Q L + E + + ++ +E + I + EE+Q LL + + Q +E
Sbjct: 1104 GLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES 1163
Query: 5306 ---MAEEQKEKYLGL----YTILPSELSLQLAEVALDLKIRDQIQDKIKEV-EQSKATSQ 5357
+ E K + T +EL Q + V R + I E Q
Sbjct: 1164 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ 1223
Query: 5358 ELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLME-LDAAVQKFL 5416
ELSRQ++ + + ++ ++ D ++ T + L L+ KL + LD + +
Sbjct: 1224 ELSRQLEVVESSIPSV-GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLI 1282
Query: 5417 EQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAK 5476
+ L ++ +L E + L +L H Y ++ W++ AK
Sbjct: 1283 SIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAK 1339
Query: 5477 -VLAHGTIAWNSASQLREQYILH-QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQ 5534
L T + Q E H LE SKE+D++ + L + +K+
Sbjct: 1340 DRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV--D 1397
Query: 5535 VAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPE----VG 5590
A L E + L N+ + + + + + + A+ + + ++ E
Sbjct: 1398 TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKD 1457
Query: 5591 RLSLKEQLSHR--QHLLSEMESLKPKVQAVQLC-----QSALRIPEDVVAS-----LPLC 5638
++K + ++ L + + K + QL QS L+I V S
Sbjct: 1458 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 1517
Query: 5639 HAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATS 5698
+ + LQ ++ +++ + + +YE ++ L+ E + ++ +
Sbjct: 1518 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH-RIG 1576
Query: 5699 NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTE 5758
+ +Q + ++L IK ++++ + L K + ++ + L +
Sbjct: 1577 DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWA 1636
Query: 5759 DLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE-SGEEGTNSEISS--PPACRSPSPVA 5815
+LD G+ LL V ++ S + +I+S A S S
Sbjct: 1637 NLD---------------HMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR 1681
Query: 5816 NTDASVNQDIAYYQALSAERLQTDAAKIHPS-------TSASQEFYEPGLEPSATAKLGD 5868
S+ + Q + + LQ D K S T+ + P + + T L +
Sbjct: 1682 LLTGSL--EAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 1739
Query: 5869 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ W L I+E+ ++ L+ Q+Y+D + ++ ++ E + +E + + +
Sbjct: 1740 VNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIA 1799
Query: 5929 MAEHQALMDEILMLQDEINELQSSL--AEELVSE-SCEADPAEQLALQSTLTVLAERMST 5985
E + + L + ++ SL EL + + D + A+QS L++ +
Sbjct: 1800 DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 1859
Query: 5986 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP 6045
+ ++ L+ + D + +AL+ + EA+E+ L + + LS +E
Sbjct: 1860 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEI---LQGQDPSHSSDLSTIQER 1916
Query: 6046 M-DMEAQLMDCQNMLVEIEQKVVALSELSVHNENL--LLEGKAHTKDEAEQLAGKLRRLK 6102
M +++ Q++ +M ++++ L ++++ + + H + Q + +L+
Sbjct: 1917 MEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQ 1976
Query: 6103 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ 6162
LL+ Q L + M+ Q +++ V++ S Q L Q R
Sbjct: 1977 SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI----SGNYQHLLEQQRA------------ 2020
Query: 6163 QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAED 6222
+ + E+ ++ +L S+ G+ L++ + + K +LS +
Sbjct: 2021 HELFQAEMFSRQQILHSIIIDGQR-LLEQGQVDDRDEFNLKLTLLSNQ------------ 2067
Query: 6223 QMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRL----LSGVPLY-KGDVPTQDK 6277
W+ + + ++ ++ + + Q Q + R +S +P+ G VP +
Sbjct: 2068 -----WQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQ 2122
Query: 6278 SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY-----DGVSATSTWLDDVEERLFV 6332
A T L D + Q E+V + G+ ++ ++L +A L +++E+
Sbjct: 2123 QART-LFDEV-QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKS 2180
Query: 6333 ATALLPEETETCLF---NQEILAKDIKEMSEEMDKNKNLFSQAFPENGD----------- 6378
A+ L E+ + F + E K I + E++ K SQ+ P++ +
Sbjct: 2181 ASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE 2240
Query: 6379 -------------NRDVIEDTLGCLLG---------RLSLLDSVVNQRCHQMKERLQQIL 6416
+++DTL + R+ LL + CHQ+ R QQI
Sbjct: 2241 LENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIG 2300
Query: 6417 NFQND--------------LKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGL 6462
N+ L + + ++ N I+++++ ++ E+I Q+ + L
Sbjct: 2301 ERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQL 2360
Query: 6463 KEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER 6522
++ + + ++E +L K+ D + L+ +I +R L + L Q ++
Sbjct: 2361 QQMGERLAKASHESKASEIE----YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDK 2416
Query: 6523 ALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH-------MILTET 6575
+ L L + ++A + EEIQ+ L++ +E + +E H + L E
Sbjct: 2417 NMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEV 2476
Query: 6576 LFRKIISFAVQKE----TQFHTELMAQASAVLKRAHKRGVELEYILETW-SHLD-----E 6625
L + A E Q L + + + +R +++E W LD E
Sbjct: 2477 LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFE 2536
Query: 6626 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6685
D + S + SS + V + E + + H + E K Y+ L R
Sbjct: 2537 DWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENR- 2595
Query: 6686 LISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKD 6745
+ S L+ +++ + W + +++ L RL+ + +++ ++ WL
Sbjct: 2596 --TDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL 2653
Query: 6746 RLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTA 6804
+L ++ E + V+ + F +E+ + +++ G QL+ + + +D A
Sbjct: 2654 QL-----TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA 2707
Query: 6805 TLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMD-----------KLPSRHAISEVMSWIS 6853
+ EL + ++ + +KL +L + +L A+S+ + W
Sbjct: 2708 IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSD-LHWHD 2766
Query: 6854 LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 6913
+ + + + +++ + G + + +++ + L S+D+ES
Sbjct: 2767 RSADSLLSPQPS--SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL---SRDLES 2821
Query: 6914 KRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKR 6973
S ++ G +K + L+G V GL S E+ ++ L + +
Sbjct: 2822 AMSRALPSEDEEGQDDKDF-YLRGAV--------GLSGDHSALESQIRQLGKALDDSRFQ 2872
Query: 6974 LKQQHRI------------GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQ 7019
++Q I L +C D +K E ++++ E++ G +
Sbjct: 2873 IQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLH 2932
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
+ + + ++ W L ++ +K L +W + I ++L +
Sbjct: 2933 STETQTAGVI--------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 2984
Query: 7080 YSLSRFRL--LTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7137
L + + L+ ++ +++Q+ L+ LQ ++ ++ + ++ + + +
Sbjct: 2985 EELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRD 3043
Query: 7138 LTNTLKEVNMRWN---NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7194
L + L ++N RW+ +LLEE LQ AL+Q Q + + S ++ + R NE+
Sbjct: 3044 LQDRLSQMNGRWDRVCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEI 3100
Query: 7195 LKAATNKD--IADDEVATWIQDCNDLLK 7220
+ +N D I D +Q ++LL+
Sbjct: 3101 VPIDSNLDAEILQDHHKQLMQIKHELLE 3128
Score = 149 bits (375), Expect = 2e-34
Identities = 553/3140 (17%), Positives = 1188/3140 (37%), Gaps = 397/3140 (12%)
Query: 2835 AKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELI 2894
A+ ++ K+ + Y + + W+ AK H + S ++ + L
Sbjct: 39 AENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLE 98
Query: 2895 DSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENL 2954
+S+EI S +E++ +++ T+ E M ++ L + ++ + + L+NL
Sbjct: 99 ESKEID----SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI---KIRLQNL 151
Query: 2955 VSQMALSEQEFSGQVAQLEQALEQFSALLKT-WAQQLTLLEGKNTDEEIVECWHKGQEIL 3013
A ++F ++ +L+ ALEQ A L + +L+L E + + ++ + +
Sbjct: 152 -QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV 210
Query: 3014 DALQKAEPRT---EDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQAS----KGCQ 3066
A+Q + ED+ + L LC + L + ++ + C +QA+ + +
Sbjct: 211 QAVQLCQSALRIPEDVVASL-PLCHAALRLQEEASRLQHTAIQ-QCNIMQAAVVQYEQYE 268
Query: 3067 NKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQH 3126
+ + LQQ A R+ + + + T+ ++ IS QKI+ + + +
Sbjct: 269 QEMKHLQQLIEGAHREIE----DKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 324
Query: 3127 KLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE 3186
K M+ K + + LLT + +G+ E ++ L SA ++ +
Sbjct: 325 KCKMLTMKAKHATMLLTVTEVEGL-------AEGTEDLDGELLPTPSAHPSVVM------ 371
Query: 3187 VSAEPIQDWLSK-TEKMVHESSNRLYDLPAKRREQQKL----QSVLEEIHCYEP-QLNRL 3240
++A LS TE+ E +N P R + SV ++I Y+ RL
Sbjct: 372 MTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERL 431
Query: 3241 KEKAQQLWEGQAASKSFRH---------RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQ 3291
+ A ++ +AS+ F ++ L + L N+ EK L + +
Sbjct: 432 QTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQK 491
Query: 3292 FSLGIKELQDWMTDAIHMLDSYCHP--TSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3349
+ ++ + M L P + + + + + L E L+ + E+Q +
Sbjct: 492 YQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSL--- 548
Query: 3350 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKS------------------QL 3391
L + S E P Q LQS + A +S IR K+ +
Sbjct: 549 --AEELVSESCEADPAEQLALQSTLTVLAERMST-IRMKASGKRQLLEEKLNDQLEEQRQ 605
Query: 3392 EGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAELRDKTTMLGKAKLLNE 3444
E AL ++ D + W+ S +A L+ E A+L D ML + + +
Sbjct: 606 EQALQRYRCEAD---ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE---IEQ 659
Query: 3445 EVLSYSSLL---ETIEVKGAGMTEHYVTQL--ELQDLQERYRAIQERAKEAVTKSEKLVR 3499
+V++ S L E + ++G T+ QL +L+ L+ +Q + + +
Sbjct: 660 KVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ 719
Query: 3500 LHQEYQRDLKA-----FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3554
+E DL A + WL Q + Q +++L+ +EL+ AE ++
Sbjct: 720 EKEESDVDLTATQSPGVQEWLAQARTTWTQ---------QRQSSLQQQKELEQELAEQKS 770
Query: 3555 LLNSVLHTREDVI---------------------PSGIPQAEDRALESLRQDWQAYQHRL 3593
LL SV E+++ G+ + A + +R W++
Sbjct: 771 LLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEF 830
Query: 3594 SETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDE 3653
S K +L++ +Q E + + + V Y+ +V D+
Sbjct: 831 S----------TKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV--------PTQDK 872
Query: 3654 SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES-ESSLSSYSDWYGSTHKN 3712
S V T L +V Q + + LE+ +S+ S W +
Sbjct: 873 SAV--------TSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEER 924
Query: 3713 -FKNVATKIDKVDTVMMGKKL--KTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGE-A 3768
F A ++ +T + +++ K ++ + ++M+K +L A + E G+
Sbjct: 925 LFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQA---------FPENGDNR 975
Query: 3769 ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAE-----YQEI 3823
+ + + + +L L S V + +++ L F + K L +A+ Q++
Sbjct: 976 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 1035
Query: 3824 LHVPEEPKME-----------LYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV 3872
+V E+P E L E A + + K + +PS++ + + + EL+
Sbjct: 1036 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 1095
Query: 3873 -----------QDVTLKDKIDQLQSDYQDLCSIGKAMM-----------EEIAGFEDR-- 3908
Q++TLK + ++ D DL G+ M EEI D+
Sbjct: 1096 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHK 1155
Query: 3909 -----LNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
L + + +TL + K Q H L SA+ A + LE+
Sbjct: 1156 EYFQGLESHMILTETLFRKIISFAVQKETQ-FHTELMA---QASAVLKRAHKRGVELEYI 1211
Query: 3964 LQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLC 4023
L+ + Q+ L V+ + + I ++ ++ L+ Y L
Sbjct: 1212 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLY 1271
Query: 4024 SMCD-----LSNASVKTTAKDIQQ-------TEQTIEQKLVQAQNLTQGWEEIKHLKSEL 4071
+ D L + S + Q + ++L + + + + W + ++L
Sbjct: 1272 QVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADL 1331
Query: 4072 WIYLQDADQQLQNMKRRHSEL--ELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVN--- 4126
+LQ A +L+ ++ + EL + ++ ++ +F K++ ++ + ++++ N
Sbjct: 1332 IHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 1391
Query: 4127 KLTKKEESPEHKEINHLNDQWLDLCRQ----SNNLCLQREEDLQRTRDYHDCMNVVEVFL 4182
+L K + + E++ ++ QW DL L + + L + M+ + +
Sbjct: 1392 RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLME 1451
Query: 4183 EKFTTEWDNLARSDAESTAVH--LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDK 4240
+ DN+ S A+H L+ K + + ++ + D +Q I +++ K
Sbjct: 1452 NVIQKDEDNIKNSIGYK-AIHEYLQKYKGFKIDINCKQLTV-DFVNQSVLQISSQDVESK 1509
Query: 4241 ELVK----EQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4296
K EQ + + W L+ L+ KIQ+ LE + ++ Q L W E Q+ +
Sbjct: 1510 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRL 1569
Query: 4297 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKAL 4356
+ + + QN L D C +LE LIK ++ + + N +IQ
Sbjct: 1570 KQQHRIGDQASV-QNALKD----CQDLE-------DLIKAKEKEVEKIEQNGLALIQNKK 1617
Query: 4357 SDAQSHVNC-----------LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI 4405
D S V L +VGQ + L L + + +A + S + + +
Sbjct: 1618 EDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSL 1677
Query: 4406 MFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKL 4465
+ + V QV ++ Q L+ + + + +L+KE + L
Sbjct: 1678 SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTL 1737
Query: 4466 QELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEI-----NL 4520
+E+ ++++L++ + +LQ + L + +K D+ K C Q E+ N
Sbjct: 1738 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYK-DYSKQCASTVQQQEDRTNELLKAATNK 1796
Query: 4521 MNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN-------EVDHSYLSEK 4573
E+ T + ++L+ ++ L L G+ + ++ + D LS+
Sbjct: 1797 DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 1856
Query: 4574 LNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDL 4633
L AL + AL K + +Q +L + +A +E + +EA+ + + P+
Sbjct: 1857 LCALEQ------ALCKQQ-TSLQAGVLDYETFAKSLEALEAWI--VEAEEILQGQDPSHS 1907
Query: 4634 AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKE-GFRSTGQPWQPDKMLHLVTLYHRLK 4692
+ + ++Q+ + ++ +L++ E G+R + +M +L + +
Sbjct: 1908 S--DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLIS 1965
Query: 4693 RQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE-------TLPAEEKLK 4745
QT +R S L+ S +H+ ++ E ++ + + + K+ E L + +
Sbjct: 1966 SQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHE 2022
Query: 4746 MYHSLAGSLQD--SGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4803
++ + S Q I++ + + D K WQG ++ G
Sbjct: 2023 LFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL-KLTLLSNQWQGVIRRAQQRRG- 2080
Query: 4804 TVTECESRMVQSIDFQTEMSRSLDWLRRVK-AELSGPVYLDLNLQDIQEEIRKIQIHQEE 4862
+ + + R Q E R WL V +SG + + LQ + ++Q ++
Sbjct: 2081 -IIDSQIRQWQRYREMAEKLRK--WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKV 2137
Query: 4863 V--QSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4920
Q I+ + K+ L+SAD A +EL +IQE ++ L E
Sbjct: 2138 FLRQQGSYILTVEAGKQL--------LLSADSGAEAALQAEL-AEIQEKWKSASMRLEEQ 2188
Query: 4921 YSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTED------QF 4974
+ + ++ + D+ E L+ L + + + H E ++ +
Sbjct: 2189 KKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSW 2248
Query: 4975 HSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHD 5034
+L +L L TL I L ++V L+ + + + + + +W
Sbjct: 2249 TDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV 2308
Query: 5035 YQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEK 5094
+ + +E+ E + E K+S+ + E +K + + ++ E + L++
Sbjct: 2309 FSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA-----QENKIQLQQM 2363
Query: 5095 ASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATE 5154
+L K +++ + + + V RW L + + K L++ + + +
Sbjct: 2364 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 2423
Query: 5155 MIDQLQDKLPGSSA-EKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAA 5213
+ ++ +L + + E+ L ++E+ + + + +L D A
Sbjct: 2424 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 2483
Query: 5214 PTPGEEPPLMQEITAMQDR-----CLNMQE---KVKTNGKLVKQELKDREMVETQINSVK 5265
E +Q+ T DR C E K++ +L ++ L D E + S
Sbjct: 2484 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 2541
Query: 5266 CWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSEL 5325
+ T + + + EEL+ + + ++ E ++Y L ++
Sbjct: 2542 --SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL-ELINKQYRRLARENRTDS 2598
Query: 5326 SLQLAEVALDLKIR-DQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNV 5384
+ L ++ + R D +Q ++ + + + + + LT++ + N+
Sbjct: 2599 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 2658
Query: 5385 -------VQAKTDQ-KVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTEL 5436
VQAK Q K +E+ ++K+ ++ A ++ +E++ L + ++ +L EL
Sbjct: 2659 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE--ELDEL 2716
Query: 5437 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN--SASQLRE- 5493
++ ++ R+ + ++ L ++ +L + +E A + W+ SA L
Sbjct: 2717 -RRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSP 2775
Query: 5494 ------QYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE-LGRETEELR 5546
L Q L E D+ + L++ + + ++ L E EE +
Sbjct: 2776 QPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ 2835
Query: 5547 QMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ------------ATLTSPEVGRLSL 5594
L+ + D E+++++L AL+ ++ T T PE L
Sbjct: 2836 DDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-----L 2890
Query: 5595 KEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA----ALRLQEEASR 5650
LL E S + +V+ + L+ E+ + H+ + +
Sbjct: 2891 DTSYKGYMKLLGECSS---SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWEL 2947
Query: 5651 LQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIE--DKPVATSNIQELQAQIS 5708
LQ A+ + M+ + +++Q+ ++ + + E+E + +++IQ ++ QI
Sbjct: 2948 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 3007
Query: 5709 RHEELAQKIKGYQEQIASLN 5728
+ +EL + + + I S+N
Sbjct: 3008 KLKELQKAVDHRKAIILSIN 3027
Score = 117 bits (293), Expect = 5e-25
Identities = 630/3375 (18%), Positives = 1244/3375 (36%), Gaps = 527/3375 (15%)
Query: 3488 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQV 3547
K K KL LHQ+ R + L Q L++Y+ + E L+ +++ +V
Sbjct: 19 KPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEML------ELILKWIEKAKV 72
Query: 3548 HCAEGQALLNSVLHTREDVIPSGIPQAE----DRALESLRQDWQAYQ-----HRLSETRT 3598
A G NS RE I E D LE++ + Q ++S+
Sbjct: 73 -LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVA 131
Query: 3599 QFNNVVNKLRLMEQ-KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVN 3657
+ +LR M + + Q + + K + KK+ E+ + +E+ AQ L V
Sbjct: 132 ELGRETEELRQMIKIRLQNLQDAAK--DMKKFEAELKKLQAALEQ----AQATLTSPEVG 185
Query: 3658 SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVA 3717
R+ + QL+ R +L +++ L+ ++Q+++ +S+L D S + A
Sbjct: 186 -RLSLKE-QLSHRQH-----LLSEMESLKPKVQAVQLCQSALRIPEDVVASLP--LCHAA 236
Query: 3718 TKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHD 3777
++ + + + ++ ++ + + E+ E+ +K+L++ L + H
Sbjct: 237 LRLQEEASRLQHTAIQQCNIMQAAVVQ--------YEQYEQEMKHLQQ-----LIEGAHR 283
Query: 3778 HMEQLKELTSTVRKEHMTLEKGLHLAKEF----------SDKCKALTQWIAEYQEILHVP 3827
+E TS +++ + + LA++ + KCK LT +L V
Sbjct: 284 EIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 343
Query: 3828 EEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSD 3887
E L E L L T +H V + LL V + + ++ + S
Sbjct: 344 EVEG--LAEGTEDLDG--ELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISS 399
Query: 3888 Y------QDLCSIGKAMMEEIAGFE----DRLNNLQMKGDTLIGQCADHLQAKLKQNVHA 3937
+ + ++ ++IA ++ +RL K + + L+ + A
Sbjct: 400 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATA 459
Query: 3938 HLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLS 3997
L + S+ + + ++L L++ QD+LQ + A++ L SP+P
Sbjct: 460 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEP--G 517
Query: 3998 RAEAIKQVKHFRALQE-----------QARTYLDLLCSMCDLSNAS-------------- 4032
R+ + +H + E Q+ +L+ C+ A
Sbjct: 518 RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAER 577
Query: 4033 VKTTAKDIQQTEQTIEQKL---VQAQNLTQGWEEIKHLKSEL--WIYLQDA--DQQLQNM 4085
+ T Q +E+KL ++ Q Q + + EL W+ A D L
Sbjct: 578 MSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP 637
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
K E +L QNM+ +++ V L ++ + TK E ++ L
Sbjct: 638 KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLK 697
Query: 4145 DQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNV-----VEVFLEKFTTEWDNLARSDAES 4199
L+L R ++ L + Q + + V+ +L + T W +S
Sbjct: 698 GSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS--- 754
Query: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQK-MIEHL------NLDDKELVKEQTSHLEQ 4252
L+ K+L L E+K + + + ++ +I+H + +K V Q +E
Sbjct: 755 ----LQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEG 810
Query: 4253 RWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ----QPNIAEALKQSPPPDM 4308
ED ++ K + + +E + Q Q ++E +EQ +PN L P
Sbjct: 811 EKSSAEDQMRMKWE---SLHQEFSTKQKLLQNVLEQEQEQVLYSRPN---RLLSGVPLYK 864
Query: 4309 AQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVI--QKALSDAQSHVNCL 4366
D A+ S LL L + + V + G +RQ I ++ L D S +
Sbjct: 865 GDVPTQDKSAVTS-------LLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTW 917
Query: 4367 SDLVGQRRKYLNKALSEKT------QFLMAVFQATSQIQQHERKIMFREHICLLPD--DV 4418
D V +R L E+T Q ++A + + K +F + D DV
Sbjct: 918 LDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDV 977
Query: 4419 SKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTE-QEKSEVLGK---------LQEL 4468
+ C + SL + V Q +E ++++ Q +VL LQ+L
Sbjct: 978 IEDTLGCLLGRLSL--LDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 1035
Query: 4469 QSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELH 4528
+V++ + + +Q+ E L ++FD LK+ E M E S+L
Sbjct: 1036 ANVFEQPVAEQIEAIQQAEDGL-------KEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 1088
Query: 4529 TQLAKYQNILEQSPEYENLLLTL----QRTGQTILPSLNEVDHSYLSEKLNALPRQFNVI 4584
+ I+ N LTL +R Q + L ++ + + +
Sbjct: 1089 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 1148
Query: 4585 VALAKDKFY---KVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSL 4641
L K K Y IL + +I Q ++ + + + A + + L
Sbjct: 1149 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 1208
Query: 4642 QDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQ-----PWQPDKMLHLVTLYHRLKRQTE 4696
+ IL+ + L E EL+++ E S+ D+++ +TLY LK
Sbjct: 1209 E----YILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKS--- 1261
Query: 4697 QRVSLLEDTTSAYQEHEK--------MCQQLERQLKSVKE----EQSKVNEETLPAEEKL 4744
SL E YQ + C LE QL + E +K+++E E L
Sbjct: 1262 ---SLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETIL 1318
Query: 4745 KMYHSLAGSLQDSGIVLKRVTIHLEDLAPH--LDPLAYEKARHQIQSWQGELKLL--TSA 4800
K + D L+ LE P E R + ++ K + S+
Sbjct: 1319 KHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSS 1378
Query: 4801 IGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4860
+ +V +++++ T RS L R+ ++ + L N+ +QE++ ++Q+ +
Sbjct: 1379 LKSSVLSTGNQLLRLKKVDTATLRS--ELSRIDSQWTD---LLTNIPAVQEKLHQLQMDK 1433
Query: 4861 -------EEVQSSLRIMNALSHKEKEKFTKA----------------------KELISAD 4891
EV S + +M + K+++ + K+L
Sbjct: 1434 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 1493
Query: 4892 LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNG 4951
+ S+ ++S D E+ R+ + E + +Q+ Q E +QL
Sbjct: 1494 VNQSVLQISSQD---VESKRSDKTDFAEQLGAMNKSWQILQGL------VTEKIQLLEGL 1544
Query: 4952 LDVESA-EENLKSHMEFFSTEDQFHSNLEELHSL------------VATLDPLIKPTGKE 4998
L+ S E N++ +F T+++ L++ H + L+ LIK KE
Sbjct: 1545 LESWSEYENNVQCLKTWFETQEK---RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE 1601
Query: 4999 -------------DLEQKVASLELRSQRMSRDSGAQVD--------LLQRCTAQWHDYQK 5037
+ ++ V+S+ + + R + A +D LL+ QW ++
Sbjct: 1602 VEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKV 1661
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A +++ + + LS F LL T S + ++ + L + + +Q
Sbjct: 1662 AFDKINSYLMEARYSLSRFRLL-TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQ 1720
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L K + TL+ ++ V RW L +Q + + + W + + K+ +
Sbjct: 1721 LLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQ 1780
Query: 5158 QLQDK----LPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ---- 5209
Q +D+ L ++ + + E+ T ++ + + L + +L L + + Q
Sbjct: 1781 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 1840
Query: 5210 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ 5269
A+ ++ L Q + A++ Q ++ + D E + +++ W+
Sbjct: 1841 SAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG-------VLDYETFAKSLEALEAWIV 1893
Query: 5270 ETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQL 5329
E +E L + L +Q E+M EE K + L ++ P +L +L
Sbjct: 1894 EAEEILQGQDPSHSSDLSTIQ-------------ERM-EELKGQMLKFSSMAP-DLD-RL 1937
Query: 5330 AEVALDLKIRDQIQDKIKEVEQ--SKATSQELSR--QIQKLAKDLTTILTKLKAKTDNVV 5385
E+ L + D+ +++ + + S +SQ R ++Q T L K + + +V
Sbjct: 1938 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 1997
Query: 5386 QAKTDQKVLGEELDGCNSKLMELDAAVQKF--------------------LEQNGQLG-- 5423
Q T+QK L E+ G L+E A + F L + GQ+
Sbjct: 1998 Q--TEQK-LAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDR 2054
Query: 5424 KPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVL----- 5478
K+ L+ Q IR+A+ R ++ + Y EM E + KW+ + L
Sbjct: 2055 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 2114
Query: 5479 ------------AHGTIAWNSASQLREQ--YIL-----HQTLLEESKEIDSELEAMTEKL 5519
+ + LR+Q YIL Q LL ++ L+A ++
Sbjct: 2115 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEI 2174
Query: 5520 QYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
Q EK L + ++L ++K + + A ++K KKL +L
Sbjct: 2175 Q--------EKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD 2226
Query: 5580 AQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASL---- 5635
L + ++ L+ + L+++ LK + A + + I + V L
Sbjct: 2227 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA-YISADDISILNERVELLQRQW 2285
Query: 5636 -PLCH-AALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDK 5693
LCH +LR Q+ RL A+ + ++ K L + + ++E K
Sbjct: 2286 EELCHQLSLRRQQIGERLNEWAV---------------FSEKNKELCEWL----TQMESK 2326
Query: 5694 PVATSNIQELQAQISRHEELAQKI-KGYQEQIA-SLNSKCKMLTM-----KAKHATMLLT 5746
+I EE+ +K+ K YQE+IA + +K ++ M KA H +
Sbjct: 2327 VSQNGDI--------LIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHES---K 2375
Query: 5747 VTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE-ESGEEGTNSEISSP 5805
+E+E D LL +A + T L ++ + SE++ P
Sbjct: 2376 ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKP 2435
Query: 5806 ---PACRSP--SPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEP 5860
+C S N + +DI + A L +H + + + ++
Sbjct: 2436 IVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQ 2495
Query: 5861 SATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPE 5920
+ +L R W + + E++ + E QK+ D +++ E +
Sbjct: 2496 ATR----NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSS 2551
Query: 5921 PG------RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQS 5974
G + + Q + E L + IN+ LA E ++S +L+
Sbjct: 2552 SGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA-------CSLKQ 2604
Query: 5975 TLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
+ +R ++ + + + L+ + QR+E + D + WL T+
Sbjct: 2605 MVHEGNQRWDNLQKRVTSILRRLKHFIG-----QREE-----FETARDSILVWL--TEMD 2652
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L D++A++ + EI + ++ E L+ + + E+
Sbjct: 2653 LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 2712
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQE--WLAQARTTW 6152
+LRR + H K + + E + SD +L S + + W ++ +
Sbjct: 2713 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 2772
Query: 6153 TQQRQSSLQQQKELEQELAEQKSLLRSVASRG----------------EEILIQHSAAET 6196
+ SS L Q L ++S + AS E + + +E
Sbjct: 2773 LSPQPSS-NLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSED 2831
Query: 6197 SGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESL-HQEFSTKQKLLQNVLEQEQE---- 6251
+K L +G+ G+ S+ E Q+R ++L F +Q +N++ +
Sbjct: 2832 EEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQ--TENIIRSKTPTGPE 2889
Query: 6252 --------QVLYSRPNRLLSGVPLYKGDVPTQDKS--------AVTSLLDGLNQAFEEVS 6295
L + + V + + +++S + + G+ +E +
Sbjct: 2890 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQ 2949
Query: 6296 SQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILA 6352
+Q+ + +Q++ Q+ +++ WL D EE L L E T + E+
Sbjct: 2950 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL---ELSTDIQTIELQI 3006
Query: 6353 KDIKEMSEEMDKNK------NLFSQAF--PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR 6404
K +KE+ + +D K NL S F ++ ++RD ++D L + GR + S++ +
Sbjct: 3007 KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRD-LQDRLSQMNGRWDRVCSLLEEW 3065
Query: 6405 CHQMKERLQQILNF---QNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDG 6461
+++ L Q F + L ++ ++ K I+ +N+ + + + + + Q +
Sbjct: 3066 RGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHE 3125
Query: 6462 LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYE 6521
L E + L+ +L V L + ++ +IG+R L L S++
Sbjct: 3126 LLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVH-----VIGNR---LKLLLKEVSRHI 3177
Query: 6522 RALQDLADLLETGQE 6536
+ L+ L D+ + Q+
Sbjct: 3178 KELEKLLDVSSSQQD 3192
Score = 107 bits (267), Expect = 5e-22
Identities = 376/2167 (17%), Positives = 804/2167 (37%), Gaps = 284/2167 (13%)
Query: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 498
Q++ + IQ+ L++HK+ Q ++H ++R + Q E
Sbjct: 1137 QKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAV-----QKETQFHTELM 1191
Query: 499 VSSTSELHLMKMEFLELKYRLLSLLVLAESK---------LKSWIIKYGRRESVEQLLQN 549
+++ L +EL+Y L + L E + ++S I G E E L +
Sbjct: 1192 AQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLID 1251
Query: 550 YVSFIEN--SKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVE 607
++ ++ S E YQ+L + + S E++ +N+ W + + +
Sbjct: 1252 RITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQ-----LNQLGECWLSNTNK 1306
Query: 608 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 667
+ LE ++ +W RY + A L WL+ A+ L +F+ + Q M
Sbjct: 1307 MSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL--------EFWTQQSVTVPQELEM 1358
Query: 668 -NDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT 726
D N +E E+ ++ + +L G +V E+ R+ ++TD +
Sbjct: 1359 VRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTN 1418
Query: 727 LSAFATEAHK----------KLSEPLEVSFMNVKLLIQDLEDIEQRVPV----------- 765
+ A + H+ +SE + + ++ +D ++I+ +
Sbjct: 1419 IPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYK 1478
Query: 766 ---MDAQYKIIT-----------KTAHLITKESPQEEGKEMFATMSK----LKEQLTKVK 807
+D K +T + + +K S + + E M+K L+ +T+
Sbjct: 1479 GFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKI 1538
Query: 808 ECYSPLL-----YESQ-QLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQK 861
+ LL YE+ Q L E +++ +G + L+ L K K
Sbjct: 1539 QLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 1598
Query: 862 HQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQT--RLQRQIADIHVAFQSMV 919
+E+ ++N L LI+ + V V + L+ QT L + + + +S++
Sbjct: 1599 EKEVEKIEQN---GLALIQNKKEDVSSIV--MSTLRELGQTWANLDHMVGQLKILLKSVL 1653
Query: 920 KKTGDWKKHVETNSRLMKKFEESRAELEK---------VLRIAQEGLEEKGDPEELLRRH 970
+ W H ++ E+R L + +++ + L+ D E R
Sbjct: 1654 DQ---WSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS 1710
Query: 971 TEFFSQLDQRVLNAFLKAC-----DELTDILPE------------QEQQGLQEAVRKLHK 1013
+ F + N LK C + LT+ L E EQ +A+ +L +
Sbjct: 1711 LQKFGS----ITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQ 1766
Query: 1014 QWKDLQGEAPYHLLHLK------IDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKE 1067
++KD + + + + N+ +A +E T + L+ G+ +K+
Sbjct: 1767 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIAD-DEVATWIQDCNDLLKGLGT---VKD 1822
Query: 1068 HRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLM 1127
F H L E+ Q ++ D + + C L A+ L
Sbjct: 1823 SLFFL-----HELGEQLKQQVDASAASAIQSDQLSLSQHLC-----ALEQALCKQQTSLQ 1872
Query: 1128 EDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGET 1187
++ + +WI E L+G + +++ ++ +EE++ + K
Sbjct: 1873 AGVLDYETFAKSLEALEAWIVEAEEILQG--QDPSHSSDLSTIQERMEELKGQMLKFSSM 1930
Query: 1188 LSWLKSRLKVLTEVSSENEAQKQGDEL--------AKLSSSFKALVTLLSEVEKMLSNFG 1239
L ++ + ++ K+ L ++ + F L + L + + L
Sbjct: 1931 APDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE 1990
Query: 1240 DCVQYKEIVKNSLEELISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKK 1296
+++ + L ISG+ + Q++A ++ E +F QQ+L +R+
Sbjct: 1991 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAE-MFSRQQILHSIIIDGQRL---- 2045
Query: 1297 RDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNK 1356
+QG+ D + +L L + G+ R +++ I +R+W+R+
Sbjct: 2046 ---------LEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 2096
Query: 1357 ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLV---KEASEI 1413
E + ++L + +L S L S+ L+Q RT VQ + V ++ S I
Sbjct: 2097 EKLRKWLVEVS-----YLPMSGLGSVPIPLQQA-----RTLFDEVQFKEKVFLRQQGSYI 2146
Query: 1414 PLGPQNKQL-----------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNF 1462
KQL LQ + I+E+ K LEE K + + W+
Sbjct: 2147 LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGI 2206
Query: 1463 -ETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFV 1521
++L T K+K +L + + + K + S + L + + ++
Sbjct: 2207 ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYI 2266
Query: 1522 TTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDK 1581
+ + + + ++ ++R EEL I L++ F E +++ + +++ E K
Sbjct: 2267 SADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESK 2326
Query: 1582 LAV--PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAAL 1639
++ I I + K QE + + Q + + A A + +
Sbjct: 2327 VSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKV 2386
Query: 1640 QQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1699
+++ +L R L+ L Q+L+K +SS TWL E++ + P + S + ++
Sbjct: 2387 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI 2446
Query: 1700 EGELQLIQALQNEVVSQASFYSKLLQLKESLF----SVASKDDVKMMKLHLEQLDERWRD 1755
+ +L Q LQ ++ ++ + +L L E L + A+ + ++ LD RWR+
Sbjct: 2447 QRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRN 2506
Query: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLF--LSELQTTSEISIMDHQVALTRH 1813
+ + +R ++ Q+F + F W+K + ++S + + L +
Sbjct: 2507 ICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKF 2566
Query: 1814 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQ----LFEEASQVVER 1869
+ +V +L+ + +L R + L+ + Q L + + ++ R
Sbjct: 2567 EAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR 2626
Query: 1870 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL------IEKDLNDALQNA 1923
+ + EF + S+ L ++ ++ TN + +E D+ ++ + N
Sbjct: 2627 LKHFIGQREEFETARDSILVWLTEM--DLQLTNIEHFSECDVQAKIKQLKAFQQEISLNH 2684
Query: 1924 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADAL 1983
+E + ++ K++ E+ R ++ G VER L D
Sbjct: 2685 NKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH 2744
Query: 1984 AVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQ---ALQQRLRVFNQLEDELNSHEH 2040
+ + + + L + + D +P+ +L Q LR D S +
Sbjct: 2745 DLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 2804
Query: 2041 -ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ 2099
L W D + +++ ++R + D+ + + G + L ++
Sbjct: 2805 IPLEW---------DHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLRGAVGLSGDHS 2853
Query: 2100 NLKSAVSKV----------LENASSVIVTRTTIKDQEDLKW-AFSKHETAKNKMNYKQKD 2148
L+S + ++ ++ ++I ++T + D + + K + K
Sbjct: 2854 ALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKR 2913
Query: 2149 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDD 2208
L++ + + L +HS++ T +D+W + + R++ +L W
Sbjct: 2914 LEHKLKEEEESLPGFVNLHSTE-----TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQ 2968
Query: 2209 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2268
S + I W + ++ + L+ EL + ++ ++ + +L+EL V+
Sbjct: 2969 FNSDLNSIWAWLGDTEEELEQ--------LQRLELSTDIQT-IELQIKKLKELQKAVDHR 3019
Query: 2269 KE--LTKNLETPP----------DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQV 2316
K L+ NL +P DLQ + + + + + E +G L+D Q
Sbjct: 3020 KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 3079
Query: 2317 EKFINDITTWFTKVE---ESLMNCAQNETCEAL----KKVKDIQKELQSQQSNISSTQEN 2369
+ + + ++ ++ N E L K++ I+ EL Q ++S Q+
Sbjct: 3080 HEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQD- 3138
Query: 2370 LNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQE------SLEK--HFSES 2421
C+ +AE T ++ E V + ++ + L+E LEK S S
Sbjct: 3139 --MSCQLLVNAE-------GTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS 3189
Query: 2422 MQEFQEW 2428
Q+ W
Sbjct: 3190 QQDLSSW 3196
Score = 92.4 bits (228), Expect = 2e-17
Identities = 385/2080 (18%), Positives = 783/2080 (37%), Gaps = 278/2080 (13%)
Query: 488 QLEDMAERFHFVSSTSELHLMKMEFLELKYR-----LLSLLVLAESKLKS-WIIKYGRRE 541
+L+DM + + + L + L+ +Y L LL + K+ I +E
Sbjct: 1086 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 1145
Query: 542 SVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQW 601
++QLL + ++F+ E ++ IL +T + + +E + + M + +A
Sbjct: 1146 EIQQLLDKH------KEYFQGLE-SHMILTETLFRKIISFAVQKETQFHTELMAQASAVL 1198
Query: 602 RNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH-W 660
+ R V LE ++ W L LE E + +++ R +
Sbjct: 1199 KR--AHKRGVE--LEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRIT 1254
Query: 661 IQQH--TAMNDAGNFLIETCDE-------MVSRDLKQQLLLLNGRWRELFMEVKQYAQAD 711
+ QH +++N+ L + D+ + DL+ QL L W L K +
Sbjct: 1255 LYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECW--LSNTNKMSKELH 1312
Query: 712 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYK 771
++ + K +T + SA + + LE + Q+LE + + K
Sbjct: 1313 RLETILKHWTR-YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK 1371
Query: 772 IITKTAHLITKESPQEEGKEMF----ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEEL 827
+ + L K S G ++ + L+ +L+++ ++ LL + L +L
Sbjct: 1372 EVDAQSSL--KSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 1429
Query: 828 EKQMTSFYDSLGKINEIITVLEREAQ-------SSALFKQKHQEL-----LACQENCKKT 875
+ ++ ++ I+++E Q +S +K H+ L NCK+
Sbjct: 1430 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQL 1489
Query: 876 LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGD----------- 924
++ +QSV + + K D+T Q+ ++ ++Q + +
Sbjct: 1490 T--VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLES 1547
Query: 925 WKKHVETNSRLMKKFEESRAELEKVLRIA-----QEGLEEKGDPEELLRRHTEFFSQLDQ 979
W ++ L FE L++ RI Q L++ D E+L++ + +++Q
Sbjct: 1548 WSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 1607
Query: 980 RVLNAFLKACDELTDILPE------QEQQGLQEAVRKLHKQWKDLQGEAPYH-------- 1025
L ++++ I+ Q L V +L K + + H
Sbjct: 1608 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 1667
Query: 1026 --LLHLKIDVEKNRFLA-SVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCE 1082
L+ + + + R L S+E + ++D L Q+ EK + + F S
Sbjct: 1668 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNL--QDDLEKQERSLQKFGSITN------ 1719
Query: 1083 KRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWK---DYTSR 1139
QL++E PV +T TLKE+ ++ ++ E K R
Sbjct: 1720 ---QLLKEC------HPPVTETLTN---TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQR 1767
Query: 1140 FSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL---KSRLK 1196
+ ++S ++ Q + E + A + ++ A +E+ + + L L K L
Sbjct: 1768 YKDYSKQCASTVQQQEDRTNELLKAATNKDI--ADDEVATWIQDCNDLLKGLGTVKDSLF 1825
Query: 1197 VLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE-EL 1255
L E+ + + Q + + S +L L +E+ L C Q + L+ E
Sbjct: 1826 FLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQAL-----CKQQTSLQAGVLDYET 1880
Query: 1256 ISGSKEVQE----QAEKILDTENLFEAQQL--LLHHQQKTKRISAKKRDVQQQIAQAQQG 1309
+ S E E +AE+IL ++ + L + ++ K K + + + +
Sbjct: 1881 FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 1940
Query: 1310 EGGLP--DRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTG 1367
LP D+ + ++ L + + ++Q L + + F ET + +L QT
Sbjct: 1941 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTE 2000
Query: 1368 SSHERFLSFSSLESLSS----ELEQTKEFSKRT--ESIAVQAENLVKEASEIPLGPQNKQ 1421
+S + L EL Q + FS++ SI + + L+++ N +
Sbjct: 2001 QKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 2060
Query: 1422 L--LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNAL 1479
L L Q + + + ++ ++ I+ +W + E L W+ E ++ L
Sbjct: 2061 LTLLSNQWQGVIRRAQQRRGIIDSQIR-------QWQRYREMAEKLRKWLVE----VSYL 2109
Query: 1480 ETSS-SAMDMQISQIKVTIQEIESK-------LSSIVGLEEEAQSFAQFVTTGESARIKA 1531
S ++ + + Q + E++ K S + E + +G A ++A
Sbjct: 2110 PMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQA 2169
Query: 1532 KLTQIR--------RYGEELREHAQCL---EGTILGHLSQQQKFEENLRKIQQSVSEFED 1580
+L +I+ R E+ ++ A L E G +K +K+ QS+ + +
Sbjct: 2170 ELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE 2229
Query: 1581 KLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAF-SASARKVVNRDSCVQEAAAL 1639
+L C E + D L L ++A+ SA ++N + L
Sbjct: 2230 ELHAEQMRCK---ELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN-----ERVELL 2281
Query: 1640 QQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKV 1699
Q+Q+E++ + R+ + L W ++ WL + E+K S + D +
Sbjct: 2282 QRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ-----NGDILIE 2336
Query: 1700 EGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQI 1759
E +L + Q E+ +L Q+ E L + + ++ L ++++RW+ L +
Sbjct: 2337 EMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 2396
Query: 1760 INKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAE 1819
I R+ L+ + QQ D+ + S W+ SEL + ++ E
Sbjct: 2397 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK-----------PIVYDSCNSEE 2445
Query: 1820 VESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAE 1879
++ K E Q LQ + K S G A L+L + DC +A + Q A +L
Sbjct: 2446 IQRKLNEQQELQRDIEK-HSTGVASVLNLCEVLLHDCDACATDAE--CDSIQQATRNLDR 2502
Query: 1880 FLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSK 1939
++ ++S + R +E T + + D + D L++++ + S I +
Sbjct: 2503 RWRNICAMS---MERRLKIEETWRLWQKFLDDYSR-FEDWLKSSERTAAFPSSSGVIYTV 2558
Query: 1940 AQYHLKIGSSEQRT--SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQD---QK 1994
A+ LK + QR C + + + R+ +++ D+ LK+ + +
Sbjct: 2559 AKEELKKFEAFQRQVHECLTQLELINKQYRRL-----ARENRTDSACSLKQMVHEGNQRW 2613
Query: 1995 EELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVFNQLEDELNSHEH-ELCWLKDKAKQI 2052
+ L K + I R +E A L +++ +L + EH C ++ K KQ+
Sbjct: 2614 DNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQL 2673
Query: 2053 AQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKV---L 2109
AF E+ N++E ++LI +++ +I+ E L+ +V +
Sbjct: 2674 K----AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE--EELDELRRYCQEVFGRV 2727
Query: 2110 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2169
E ++ D+ DL + ++ +L++ + LS+L S
Sbjct: 2728 ERYHKKLIRLPLPDDEHDL--------------SDRELELEDSAA-----LSDLHWHDRS 2768
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSI------WDDVLSTRDEIEGWSNNC 2223
SL+ S + L +++ L S+ WD ++E +
Sbjct: 2769 ADSLLSPQPSSNLS--LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRA 2826
Query: 2224 VP-QMAENISNLDNHLRAEELL----KEFESEVKNKALRLEELHSKVNDLKELTKN-LET 2277
+P + E + D +LR L ES+++ L++ ++ + + ++ T
Sbjct: 2827 LPSEDEEGQDDKDFYLRGAVGLSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 2886
Query: 2278 PPDLQ-------------FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDIT 2324
P+L D +++LEH + E + + + TQ I+
Sbjct: 2887 GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWE 2946
Query: 2325 TWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELES 2384
+ + QN L+K + +L S + + T+E L L R S ++++
Sbjct: 2947 LLQAQALSKELRMKQN-----LQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 3001
Query: 2385 LGRAMTGLIKKHEAVS---------QLCSK--TQASLQES 2413
+ + L + +AV LCS TQA +ES
Sbjct: 3002 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKES 3041
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 2085 bits (5403), Expect = 0.0
Identities = 1791/6584 (27%), Positives = 3090/6584 (46%), Gaps = 591/6584 (8%)
Query: 2346 LKKVKDIQK-----ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400
LK KD++K E+ ++ Q+++++ S+ ++ LI K
Sbjct: 733 LKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDT-----------SMEESLKHLIAKGSMFD 781
Query: 2401 QLCSKTQASLQESLEKHFS-ESMQEFQEWFLGAK----------------AAAKESSDRT 2443
+L ++++ LQ ++ S ES Q L AK AA K +D +
Sbjct: 782 ELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVS 841
Query: 2444 GDSKVLEAKLHDLQNILDS-VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE--QITKAN 2500
D + K+ + Q L+S + Q L G+ + H I+S+ + + KA
Sbjct: 842 PDLDI-RLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
Query: 2501 EEFQAFLKQCLKDKQALQDCASEL-GSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPE 2559
EE + + + +K +L++ + ++ +E H +L+L++ +++ L ++ + +
Sbjct: 901 EELKNNVTEDIK--MSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEK 958
Query: 2560 KKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMT 2619
+ N+ K L+ + + + SEEG C L H +LR
Sbjct: 959 QINKEKK-------LIRRGRTKGLIKEHEACFSEEG---------CLYQLNHHMEVLREL 1002
Query: 2620 KEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILL 2679
E+L S + + L++ Q + +K + + T G
Sbjct: 1003 CEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTS-------------- 1048
Query: 2680 MKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVI 2739
K EG + + G + K Q E E +SV ES++
Sbjct: 1049 -KNEGTITTSENRGGDPHSEAPFAKSDN---QPSTEKAMEPTMKFSLASVLRPLQEESIM 1104
Query: 2740 SQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHR 2799
+ DY N L + ++ +EH LQ KF + S S ED + + +
Sbjct: 1105 EK--DYSASINSLLERYDTYRDILEHHLQ-----NNKF----RITSDFSSEEDRSSSCLQ 1153
Query: 2800 LIAKSRELYEKTEDESFKDTAQEELKTQ--FNDIMT--------VAKEKMRKVEEIVKDH 2849
++ + D +K+ LK + NDI KE+ R+++ +
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
Query: 2850 LMYLDA-------VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGAS 2902
+ L+ V + + L + LH+ + + ++ + DS
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIE 1273
Query: 2903 RLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA--- 2959
+R+E V + M + + ++ V +++ L+ L +A
Sbjct: 1274 ICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
Query: 2960 ---LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDAL 3016
LS + + A Q ++ + +K ++ L++ K + K ++LD
Sbjct: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD------KCLKMLDMS 1387
Query: 3017 QKAEPRTEDLKSQLNELCRFSRDLS-TYSGKVSGLIKEYNCL---CLQASKGCQNKEQIL 3072
K R +D + N L FS LS T+ V E N L C+ + Q +
Sbjct: 1388 FKDAERGDDTSCE-NLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDV 1446
Query: 3073 QQRFRK---------AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3123
Q + K A + ++ L+ + + +++ E++ SL ++ ++ N
Sbjct: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 3124 GQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESAL-------- 3175
Q + ++L + E+ G ++ +++K+ + L QKE ++
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQC-GRVLELLKQYQNFKSILTTLIQKEESVISLQASYM 1565
Query: 3176 --ENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCY 3233
ENLK ++ + E+ E + L +K + V + + Y
Sbjct: 1566 GKENLKKRIAEIEIVKEEFNEHLEVVDK---------------------INQVCKNLQFY 1604
Query: 3234 EPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFS 3293
LN++K + +E +A + + ++L ++ T++ L R +A ++
Sbjct: 1605 ---LNKMKTFEEPPFEKEA---------NIIVDRWLDINEKTEDYYENLGRALALWDKLF 1652
Query: 3294 LGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGES 3353
+ +W A+ ++ + D+ +L+ L V ++K + V +
Sbjct: 1653 NLKNVIDEWTEKALQKMELHQLTEEDRE-------RLKEELQVHEQKTSEFSRRVAEIQF 1705
Query: 3354 VLQNTS-PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWM 3412
+LQ++ P + ++ + + + L+ C + L G+ ++ D + G
Sbjct: 1706 LLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA-LSGSTAELREDLDQAKTQIGMT 1764
Query: 3413 DSMEANLNES----------ERQHAELRDKTTMLGKAKL-------LNEEVLSYSSLLET 3455
+S+ L+ S E Q L+ K +M+ L+E Y S+ +
Sbjct: 1765 ESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDL 1824
Query: 3456 IEVKGAGMTEHYVTQL--ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEV 3513
K + + +H+ L + ++ + + I+ KE SE + Q+ Q
Sbjct: 1825 FNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQ-------- 1876
Query: 3514 WLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL-LNSVLHTREDVIPS--G 3570
KL + LEG + L+ ++ H + L S L +E +
Sbjct: 1877 -------KLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMES 1929
Query: 3571 IPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKT-AEEKKW 3629
I QA + LE Q Q R N K + ME+ ++ + + + A +++
Sbjct: 1930 ICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQ 1989
Query: 3630 HEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3689
E V + ++E G +E + +AT L RYQ LL Q+ E +EEE
Sbjct: 1990 FESVAQLNNSLKEYGFTEEE---------EIIMEATCLMDRYQTLLRQLSE----IEEED 2036
Query: 3690 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3749
+ L + S + + D + K++K ++L E G L
Sbjct: 2037 KLLPTEDQSFNDLAH-------------------DVIHWIKEIKESLMVLNSSE-GKMPL 2076
Query: 3750 KSAREKGERAVKYLEEGEA--ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3807
+ +K + + EG+A E + K+ L + T T + LHLA +
Sbjct: 2077 EERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQW--DNTLHLASTYL 2134
Query: 3808 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3867
+ L + E ++ L E+ ++ L E K + +LQ + + +K ++
Sbjct: 2135 SHQEKL---LLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKK---- 2187
Query: 3868 LLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHL 3927
L+ QD+T K + Q +Y C+ + EE L++K HL
Sbjct: 2188 FLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPW--------LEIK----------HL 2229
Query: 3928 QAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPD 3987
L Q + Q Q+L+ +++H S Q + L +
Sbjct: 2230 HESLLQQL------------------QDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKE 2271
Query: 3988 LEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTI 4047
P+ + ++++ + L+ + S+ D + + AK ++Q ++
Sbjct: 2272 FVSFSDKPVDQIAVEEKLQKLQELENRL--------SLQDGTLKKILALAKSVKQNTSSV 2323
Query: 4048 EQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD- 4106
QK+++ ++IK L+ + +D + +L + K+ +I ++ S K
Sbjct: 2324 GQKIIK--------DDIKSLQCKQ----KDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 4107 -FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL 4165
F + KQA+ + + E + E+ E EIN D +++ S L L +E +
Sbjct: 2372 KFTLPGREKQAT-SDVQESTQESAAVEKLEEDWEIN--KDSAVEMA-MSKQLSLNAQESM 2427
Query: 4166 QRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLK 4225
+ T D L+ E D + R++ LE ++KL L+ +K AI+ L+
Sbjct: 2428 KNTEDERKVNE-----LQNQPLELDTMLRNE------QLEEIEKLYTQLEAKKAAIKPLE 2476
Query: 4226 DQKQKMIEHLNLDDK-ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQE 4284
E LN + LV + Q L++L++ I + N E V FQE
Sbjct: 2477 QT-----ECLNKTETGALVLHNIGYSAQH---LDNLLQALITLK-KNKESQYCVLRDFQE 2527
Query: 4285 LMEWAEEQQPNIA---EALKQSPPPDMAQNLLMDHLA-ICSELEAKQMLLKSLIKDADRV 4340
+ E + E+LK P + +D + + +E ++ L +L + +
Sbjct: 2528 YLAAVESSMKALLTDKESLKVGPLDSVTY---LDKIKKFIASIEKEKDSLGNLKIKWENL 2584
Query: 4341 MADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQ 4400
+ ++++++ + + + + ++ E T + V +QQ
Sbjct: 2585 SNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQ 2644
Query: 4401 HERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-EQEKS 4459
++ + R L + ++ + L+ ++ + L Q MK + E+EK
Sbjct: 2645 QQQHLQLR----LKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
Query: 4460 EVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEIN 4519
+ + L+ ++++ L +N + + + + W K P I
Sbjct: 2701 NLEDGINNLKKQWETL-----EPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIP 2755
Query: 4520 LMNES--SELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNAL 4577
L+ + S++ + IL + E+L ++ +PSL + S L+ L L
Sbjct: 2756 LLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDK----VPSLTTYEGSDLNNTLEDL 2811
Query: 4578 PRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFL-RMSKVPTDLAVE 4636
Q+ ++V + + +++ + R + ++I + E E + R+ T+ ++
Sbjct: 2812 RNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELK 2871
Query: 4637 EALSLQDGCRAILDEV-AGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQT 4695
+ + L E+ +G+ + EL E + + D++ +L +R++R
Sbjct: 2872 HHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQR-- 2929
Query: 4696 EQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE-ETLPAEEKLKMYHSLAGSL 4754
+++T + + K C+Q + +++EE + E L +E K +L
Sbjct: 2930 -----FIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
Query: 4755 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4814
+D +K + + L D + Q+ Q ++ + E + + ++ +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE 3044
Query: 4815 SIDFQTEMS--RSLDWLRR------VKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
+Q +S R++D + +KA S P LN Q + + I K + +E+
Sbjct: 3045 HGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKK 3104
Query: 4867 LRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELS--ELDG-DIQEALRTRQAT 4916
L KEK +L + + L++ + ELS ELD + Q+ L T
Sbjct: 3105 LNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV 3164
Query: 4917 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 4976
L +I SQ Q+ + E+ + + E+ +E + + M
Sbjct: 3165 LNQIKSQLQQPLLI----------NLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEK 3214
Query: 4977 NLEELHSLVATLDPLIKPTGKEDLEQKV-ASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5035
EE S + ++ ++ EDL+ ++ S++LR+ ++ D + T Y
Sbjct: 3215 QREENSSEASDVETKLREF--EDLQMQLNTSIDLRTNVLN-------DAYENLTR----Y 3261
Query: 5036 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKA 5095
++A +E + E + + + + E L + + L S V +++
Sbjct: 3262 KEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV-------AHIQDLT 3314
Query: 5096 SQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5155
+L + +K L ++ + + + ++ + QE E ++ + + +
Sbjct: 3315 EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTN 3374
Query: 5156 IDQLQDKLPGS-SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAP 5214
+ +++ L S S+ S E L LE V L + L LRQ L +L+
Sbjct: 3375 LSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ-ILRLLR--LRC 3431
Query: 5215 TPGEEPPLMQEITAMQDRCLNMQE----------KVKTNGKLVKQELKDREMVETQINSV 5264
T + L++ ++A+ ++ L++ E ++K K V +E++ ++ +
Sbjct: 3432 TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEE 3491
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK---MAEEQKEKYLGLYTIL 5321
+ +TKE A EEL LL + +N+EK + ++ + +
Sbjct: 3492 LPEISKTKEA---------ATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542
Query: 5322 PSELSLQLAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK 5380
S +++ ++ ++++ +++V+++K Q ++ K++ + +
Sbjct: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
Query: 5381 TDNVVQ-AKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5439
T + A D E+ + S L + + +E K K +E++
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIME----------KLRIKYSEMYTI 3652
Query: 5440 TIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYIL 5497
+ E+++ + +A ++E NE+L+ + + K+ N L+++
Sbjct: 3653 VPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
Query: 5498 HQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------RETEELRQM 5548
+ E K++ EL+ KL L S E+ Q E ++ +++ Q
Sbjct: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
Query: 5549 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 5608
+ R L A M+++ LK +A +E L +P LSH H +
Sbjct: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH--HASTVQ 3828
Query: 5609 ESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA 5665
+L+ Q L S ED + + L + L + + LQ ++ +Q
Sbjct: 3829 MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRM 3888
Query: 5666 VVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIA 5725
E E+K +++ + + K + + +E + E + + I+ ++ IA
Sbjct: 3889 ADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENIRPMKKTIA 3945
Query: 5726 SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 5785
+ S L + L L + + L+ V+ T +
Sbjct: 3946 EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEI 4005
Query: 5786 --LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAA 5841
L + + + +S A + P + Q ++ Q L+
Sbjct: 4006 ENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVL 4065
Query: 5842 KIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSL 5901
+H QE E P+ T++ G + + SE++ ++ ++ +
Sbjct: 4066 NLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEV 4119
Query: 5902 QSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAE 5955
+ S K + + K SP+ S + M E +A ++Q+ +I+ +S+A+
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179
Query: 5956 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--Q 6012
L +S + + +L+ T E +T ++A + L ++E+ R E +
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
Query: 6013 ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL 6072
L + + EL+ WL ++ +E QL+ CQ ML EIE KV L E
Sbjct: 4237 VLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLET 4296
Query: 6073 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6132
++ L T+ EAE L+ KL+ +K +L ++Q L +K Q K+ S+ +
Sbjct: 4297 C---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPE 4353
Query: 6133 LTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6191
P L T Q RQ QQQ+ LE + EQK ++ + +++ Q+
Sbjct: 4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQY 4413
Query: 6192 SAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQE 6249
+ T+ ++ S E + S + Q KW+ LH E S+K KL L +
Sbjct: 4414 CQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEP 4473
Query: 6250 QEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHL 6308
Q S +L V +Y PT ++ T+ L+ L Q + +Q + I+L
Sbjct: 4474 Q----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINL 4529
Query: 6309 EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL 6368
++KL++ S L VEE L + L E+ + E LA ++K++ + K
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588
Query: 6369 FSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 6428
+A G+N +++ + L L + R +K L ++QN++K L+
Sbjct: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648
Query: 6429 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 6488
L +K + Q L + Q VAEQ++ L+ ++ + +L+ G++L + +QE
Sbjct: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708
Query: 6489 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 6548
+ KL+D+ D + ++ +R + L+ +SQ + LQ + +L++ G+EK+A S
Sbjct: 4709 VYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKS 4768
Query: 6549 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6608
K +Q ++ HK +FQ L + M+L + KI+ +Q F E + + + +++ +
Sbjct: 4769 KVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQ 4828
Query: 6609 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6668
G++L+ +L+ W DE+ L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++
Sbjct: 4829 CGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
Query: 6669 NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR 6728
+LYQ L++GK+L+ S+SC +LE Q+ +L E WLS K+ ELHRL+ +LKH
Sbjct: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS 4948
Query: 6729 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 6788
Y +S L WL+S++ L +W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V
Sbjct: 4949 YNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAV 5008
Query: 6789 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEV 6848
+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E+
Sbjct: 5009 ISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 6849 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6908
+SW++ +E+ DED++ + + LQK+K F+++++ KQ VDFVNQS+LQ+S+
Sbjct: 5069 ISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLST 5127
Query: 6909 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 6968
DVESKR ++T+FAE LG MN+ W + G++ KIQ LE LLES +E EN +Q L W E
Sbjct: 5128 CDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLE 5187
Query: 6969 TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 7028
QE+RLK + SVQ L DCQD+E+ + K K +++++Q+ L L ++ +
Sbjct: 5188 AQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLED 5246
Query: 7029 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 7088
S + EL Q +++ V QLK ++SVL +W + +D++N + Y + + +
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 7089 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 7148
SLE ++ QV+NLQ+LQD+ E E S +K + +L C P V E + + + R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKR 5365
Query: 7149 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 7208
W + + IA+QLQ +++LLQLW+ Y + + A+ ++QQE + +L + + + + +
Sbjct: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
Query: 7209 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7268
+QD +L + K++ + ++L Q ++S + SL Q LE+
Sbjct: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKM 5484
Query: 7269 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7328
L + + + ++ F LE+L+ I+ EE L D H + +E +
Sbjct: 5485 LLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNH 5537
Query: 7329 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7388
+L ++ +PD++ LNE+ +LPL+D +K +QN+NR W ++ ER S+LQ L ++
Sbjct: 5538 VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NE 5596
Query: 7389 TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 7448
FL CE W++ L + E+ L V+++ + LLEQQ+ +++ +AE+ Q I S +
Sbjct: 5597 KFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSL 5656
Query: 7449 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 7508
+LL+ ++++R EF + + L+++WQ ++ +QR+G +D +RQWQ + E L ++L
Sbjct: 5657 QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFL 5716
Query: 7509 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7568
+ S+L + G L Q R+L E++ KE F R++ + LT+EAG++LLL+ D
Sbjct: 5717 TDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKT 5776
Query: 7569 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7628
+ ++ ++++Q+ WK +L E K+ ++ W++CEK I + +L+ K +
Sbjct: 5777 KESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP 5836
Query: 7629 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7688
LP+ HE+LH E+ KELE ++ SWT +L +L +K L+ ++ +D+ +L E++E L R
Sbjct: 5837 LPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHR 5896
Query: 7689 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7748
QWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q DI IEEMIEKL+
Sbjct: 5897 QWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ 5956
Query: 7749 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 7808
KD EEI + ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKK
Sbjct: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKK 6016
Query: 7809 LKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH 7868
LKET +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+H
Sbjct: 6017 LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQH 6076
Query: 7869 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 7928
S GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWR
Sbjct: 6077 SAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWR 6136
Query: 7929 LWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI 7988
LWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELI
Sbjct: 6137 LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELI 6196
Query: 7989 NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 8048
NKQYRRLARENRTD+A LKQMVHEGNQRWDNLQ+RVT++LRRL+HF QREEFE R+S
Sbjct: 6197 NKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRES 6256
Query: 8049 ILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8108
ILVWLTEMDLQLTN+EHFSE D K++QL FQQEI+LN NKI+Q+I GEQLI+KSEP
Sbjct: 6257 ILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEP 6316
Query: 8109 LDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDL 8167
LDA +IE+EL+EL RYCQEVFGRV R+H++L P +DE + S+ E ++ED +
Sbjct: 6317 LDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTD 6376
Query: 8168 HWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESA 8227
W R S +PSS SL ERSG +TP SVDSIPLEWDH D+
Sbjct: 6377 SWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG------ 6426
Query: 8228 MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI 8287
+ EDEEG +Y LSDV IPE+PEAY+K+T +K +SG S +
Sbjct: 6427 -GSSSHEEDEEG----PYY----SALSDVEIPENPEAYLKMTTKTLKASSG-KSISDGHS 6476
Query: 8288 RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEH 8344
+ + +Q E R+ P P T YK G + L + + L
Sbjct: 6477 WHVPDSPSCPEHHYKQMEG-DRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNG 6535
Query: 8345 KLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSI 8404
++E+ L G Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I
Sbjct: 6536 NPQQEDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAI 6586
Query: 8405 WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 8464
WL TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q
Sbjct: 6587 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 6646
Query: 8465 DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRR 8524
+S ES +LQ RL Q++ W+ ++ WRG L+ +LMQCQ FH++S LLL L + R
Sbjct: 6647 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6706
Query: 8525 KNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 8584
+ + D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+
Sbjct: 6707 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6766
Query: 8585 EKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRST 8644
EKVHVI +LK L ++VS + L+ + +Q S S DE+D SG P +
Sbjct: 6767 EKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPAT---- 6815
Query: 8645 PNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQ 8704
S P P R+T+G ++ PG R R FL RV+RAALPLQ
Sbjct: 6816 -------------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQ 6862
Query: 8705 LLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8748
LLLLLL+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 6863 LLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 6906
Score = 600 bits (1547), Expect = e-170
Identities = 1235/6185 (19%), Positives = 2431/6185 (39%), Gaps = 950/6185 (15%)
Query: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
LQ EQE QK+ FT WINS LA+ P V+ DLF D+K G LL LLEVLSGQ+LP ++G
Sbjct: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
Query: 81 RRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYF 140
+ NI AL FL R IKL+NI+ TDI DG PSI+LGL+WTIIL+F
Sbjct: 85 SNTFQCRI--NIEHALTFLRNRS-------IKLINIHVTDIIDGNPSIILGLIWTIILHF 135
Query: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYT 198
IE+L L S V + SS SPP+K+ KV + Q +A+KALL W Q
Sbjct: 136 HIEKLAQTL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQ 194
Query: 199 AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 258
+ V DF SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL
Sbjct: 195 CATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELK 254
Query: 259 IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQN 318
IPRLL+PEDVDV PDEKSIMTYVAQFL++ D + Q + G+ +
Sbjct: 255 IPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK---- 310
Query: 319 FKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQP 378
++++ ++ E D KY S F + ++K ++
Sbjct: 311 ---------EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSI 352
Query: 379 LHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITV 438
+L D ++++WD + ++ W I+L+ +LP PL AWL E + E+++
Sbjct: 353 KRDLDELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSA 412
Query: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFH 497
Q H + IQ K+ K L+ + H + + N +P VPP++LE+M R +
Sbjct: 413 SQDHSQAVTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRIN 471
Query: 498 FVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENS 557
+ + ++ +EF K +L L+ +SKL W IKYG RESVE LL+++ FIE
Sbjct: 472 NI--LEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEK 529
Query: 558 KFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEE 617
+F + + ++Q + E+Y G + + +R + +V+S L++
Sbjct: 530 EFLARLDTSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQK 583
Query: 618 VISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIET 677
V++ W Y + L+A E+ +K E K+ F L W +H +N+AGNFL+E
Sbjct: 584 VLACWATYVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEV 638
Query: 678 CDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKK 737
+++V + ++L LN RWR+L + +
Sbjct: 639 SNDVVGSSISKELRRLNKRWRKLVSKTQ-------------------------------- 666
Query: 738 LSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFAT 795
LE MN+ L+I+ +Q P D I++K + S E E +
Sbjct: 667 ----LE---MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQ 714
Query: 796 MSKLKEQLTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREA 852
K E+ K E ++ L + ++L+ +E E + S D +++ T +E
Sbjct: 715 NIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESL 770
Query: 853 QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 912
+ EL+A E+ +++ Q++ + +VL Q ++Q +
Sbjct: 771 KHLIAKGSMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQ 824
Query: 913 VAFQSMVKKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRH 970
+ ++VK K V + + K EES+ ELE + AQ+ L ++ P EL+ +H
Sbjct: 825 I---NVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKH 881
Query: 971 TEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1030
E + + L +LKA +EL + + E + L+E R + +W+ L E ++ LK
Sbjct: 882 KEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLK 941
Query: 1031 IDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090
ID+EK + ++ + ++++E KL+ + ++ +IKEH FS++G + ++++ E
Sbjct: 942 IDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRE 1001
Query: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTN 1150
LC +LP + ++ LK+ I+ + E + S+ I+T+
Sbjct: 1002 LCEELPSQKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTS 1057
Query: 1151 ETQLKGIKGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ 1208
E + EA + N ++A+E T+ + S VL + E+ +
Sbjct: 1058 ENRGGDPHSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIME 1105
Query: 1209 KQGDELAKLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVK 1249
K D A ++S + T +E L N C+Q K +++K
Sbjct: 1106 K--DYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIK 1163
Query: 1250 NSLE------ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQL 1281
N + E+IS KE + + + L+T E+L A +L
Sbjct: 1164 NETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRL 1223
Query: 1282 LLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERR 1341
+L ++ + + + + Q DR ++ LR ++ ++ R E
Sbjct: 1224 VLPVEKASLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEP 1281
Query: 1342 IQVTLRKWERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1398
L++ F+ + + +++Y Q G +H S +L++L L + E
Sbjct: 1282 GNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEP 1341
Query: 1399 IAVQAENLVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEED 1444
+ + + + A E L +NK+ L++ +AK + + +K L +DT E+
Sbjct: 1342 VTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCEN 1401
Query: 1445 IKTMEMVKTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV- 1495
+ +K H +G E TE+ K L N L + + QIS+I +
Sbjct: 1402 LLDAFSIKLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLK 1456
Query: 1496 --TIQEIESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRY 1539
T+ ++ + S++ L+E A S F E + + +
Sbjct: 1457 DPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLW 1516
Query: 1540 GEELREHAQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATE 1594
+CLE G +L L Q Q F+ L + ++SV + + E
Sbjct: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
Query: 1595 TYKVLQEHMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1652
V +E + + ++ ++ F + K +EA + ++ DI + ++
Sbjct: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTED 1636
Query: 1653 RQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE 1712
L LA W +L + W E+ K ++ DR +++ ELQ+ + +E
Sbjct: 1637 YYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSE 1695
Query: 1713 VVSQASFYSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLP 1757
+ + LLQ E + + + K+ H+++ E DL
Sbjct: 1696 FSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLD 1755
Query: 1758 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA-------- 1809
Q +I +S++ D L + F+ ++ LQ + ++++Q+
Sbjct: 1756 Q-AKTQIGMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSE 1813
Query: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQV 1866
L + + +++ + K + LQ H +KL D ++ ++CF+ E V
Sbjct: 1814 LKKQYESVSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
Query: 1867 VERRQLALSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES-- 1909
++ Q L + ++ H + + + V + K ES
Sbjct: 1872 EQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESIC 1931
Query: 1910 DLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERI 1969
K+L D+LQ L+ +L L+ + K G E L + E+
Sbjct: 1932 QARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQF 1990
Query: 1970 QNLLGTKQS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPT 2017
+++ S E + + + D+ + LL+ + +IEE T+ + +
Sbjct: 1991 ESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
Query: 2018 R------QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAP 2061
+ +++ L V N E ++ E E+ LK + + Q + + AP
Sbjct: 2051 HDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAP 2110
Query: 2062 EVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT 2121
V + + + WD+T L + + L K L++ + +
Sbjct: 2111 LVQKTLTDISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
Query: 2122 IKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMEST 2181
+K +++ +A +H + K + K F K + L S LK++ S L++ +
Sbjct: 2161 LKKKQEAGFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPS 2217
Query: 2182 V--DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLR 2239
+ WL++ + L E++ + Q+ +++ NLD H+R
Sbjct: 2218 FSEEPWLEI-KHLHESL---------------------------LQQLQDSVQNLDGHVR 2249
Query: 2240 AEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
E + + + +L++ +++ + + P Q + +QKL+ +
Sbjct: 2250 ----------EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRL 2299
Query: 2300 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQ 2359
+ GTLK A + V++ + + K + + C Q KD++ L S
Sbjct: 2300 SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASA 2349
Query: 2360 QSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHF 2418
+ + LNS+ + S E + T ++ +A S + TQ S E LE+ +
Sbjct: 2350 KQEMECC---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDW 2403
Query: 2419 SESMQEFQEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAV 2473
+ E + + + A+ES T D E K+++LQN LD++ +
Sbjct: 2404 EINKDSAVEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ----- 2454
Query: 2474 TQEGQTLYAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQ 2530
+E + LY L + I Q + E L Q L + L + +
Sbjct: 2455 LEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKN 2514
Query: 2531 HRKLNLWIHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESL 2581
+ + +E + + L K+ + + + K++ F+ + ++SL
Sbjct: 2515 KESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSL 2574
Query: 2582 DKLSQRGQLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALE 2637
L + + LS H + +L QL + + + ++K V E L
Sbjct: 2575 GNLKIKWENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLM 2632
Query: 2638 EALQ----SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNM 2690
+Q S+ + +Q RL E G++ + + ++KG+ E+++
Sbjct: 2633 NKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKR 2692
Query: 2691 AIGKGEQALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSS 2728
G+ E + + ++G ++ Q ETL+ +WA +
Sbjct: 2693 IWGEKE---KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGE 2749
Query: 2729 VHAQSTL--ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL 2779
++ L + ++SQ + + R+ +E E V K+ P E L
Sbjct: 2750 LNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDL 2804
Query: 2780 LDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKE 2837
+ L+ + ++ + + + +S++L K E+ S F + +L Q ++ + + +
Sbjct: 2805 NNTLEDLRNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRV 2861
Query: 2838 KMRKVEEIVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDS 2896
+ E +K H + L+A + + S L +++ + + ++ +++ + +
Sbjct: 2862 ETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKN 2919
Query: 2897 REIGASRLSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV 2955
+I +R+ R +++ EV+ C H + AL+ + DS+ + + L V
Sbjct: 2920 LKIRTNRIQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEV 2973
Query: 2956 SQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDA 3015
++ E + L+ L + L +L+ K + I W Q LD
Sbjct: 2974 NKGVKEE------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQ 3019
Query: 3016 LQ-KAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQ 3074
LQ + + ++L+ ++ +L F + GK L+ + + LQ K + +
Sbjct: 3020 LQTQVFEKEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAP 3073
Query: 3075 RFRKAFRDFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNM 3130
R +++ +I AKC +I + ++E T K +E L N + +
Sbjct: 3074 DSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKL 3133
Query: 3131 MLSKGELLSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVS 3188
++ L KE K Q K+ + S L Q L NL+I+ +++ + +
Sbjct: 3134 YKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDN 3191
Query: 3189 AEPIQD--W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI-------- 3230
E Q+ W ++ EK E+S+ D+ K RE + LQ L
Sbjct: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
Query: 3231 -HCYEPQLNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLAL 3271
YE L R KE + E + ++ + +L S +
Sbjct: 3252 NDAYE-NLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI 3310
Query: 3272 SNLTKEKVS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPT 3317
+LT EK+ L +V++++ K + T+A L++Y C+
Sbjct: 3311 QDLT-EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRK 3366
Query: 3318 SDKSVLDS------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV-------- 3354
++ + + +L L EAL ++Q K + +I T+ E +
Sbjct: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
Query: 3355 --LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWM 3412
L+ T +GI + + + ++ + W SLL A + E +W + + + + +
Sbjct: 3427 LRLRCTENDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
Query: 3413 DSMEANLNE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVK 3459
D+++ L E + + +EL D G K +LL +L ++ + E
Sbjct: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
Query: 3460 GAGMTE---HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA 3510
GA T +T ++ LQ +Q+ +Q +E + +++++ L +Q+ +
Sbjct: 3546 GAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTS 3605
Query: 3511 FEVWLGQEQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIP 3568
F+ Q+ EK +Q+ L+ + T ++ E L++ +E ++ + + ++ +
Sbjct: 3606 FQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
Query: 3569 SGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-- 3626
+ +++ + + +Y R + + N L +E+ QQ + ++ A+E
Sbjct: 3666 KALEDIDEKISNEVLKSSPSY-----AMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
Query: 3627 KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQALLLQVLEQIKFL 3685
KK +E+ + ++ E+ + Q+I+++ ++ + +YQ + + + L
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
Query: 3686 EEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKG 3745
+ +EE L S W +T N A D + T + T+++ L+D E+
Sbjct: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHASTVQMALEDSEQK 3837
Query: 3746 HSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAK 3804
H+LL S + + ++ + E + L + I + Q+ L + + +++
Sbjct: 3838 HNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVV 3893
Query: 3805 EFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSLQQT---VLSHEPS 3857
+ K++ + +++ + IL E P+ L + L + +++T ++S++
Sbjct: 3894 AIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVE 3953
Query: 3858 VKSVREKGEAL------LELVQDVTLKDKIDQLQSD-YQDLCSIGKAMMEEIAGFEDRLN 3910
++ + + L +L+QD+ L + + Q Q++ + + EEI + LN
Sbjct: 3954 LRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILN 4013
Query: 3911 N--LQMKGDTLIGQCADHLQ------AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH 3962
N Q + + AD L ++++ + + Q +D + +T ++Q L+
Sbjct: 4014 NYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQ 4073
Query: 3963 EL--------------QKHVSRQDTLQQ------CQAWLSAVQPDL-------------- 3988
E + V+ +D ++ ++L+AV+ ++
Sbjct: 4074 EQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKA 4133
Query: 3989 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4048
EPSPQ S + K ++ RA + + N+ + D TEQ E
Sbjct: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPE 4193
Query: 4049 QKL------------VQAQNL----TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL 4092
L ++A L QG E + K+ + + L K + +EL
Sbjct: 4194 CSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAEL 4248
Query: 4093 EL-----NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQW 4147
EL N+A + D + L+ + ++ ++ EHK + L +
Sbjct: 4249 ELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEI----------EHK-VAFLLETC 4297
Query: 4148 LDLCRQSNNLCLQREEDLQRTRDYHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEA 4206
D N E L C + V++ L++ +E + S H EA
Sbjct: 4298 KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEA 4357
Query: 4207 LKKLALA-----LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL---- 4257
L+ + L+ + ER Q+Q+++E ++ K+ +K + ++ W Q
Sbjct: 4358 LQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHD 4417
Query: 4258 EDLIKRKIQVSVTNLEELNVVQS----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQ 4310
D + + + E +V S + Q +W E I L Q P ++
Sbjct: 4418 NDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVST 4477
Query: 4311 NL-------------------------LMDHLAICSELEAKQMLLKSLIKDADRVMADLG 4345
N+ L D S L+ ++ + + + D+ + +L
Sbjct: 4478 NMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELF 4537
Query: 4346 LNERQVIQKALSDAQSHVNCLSDLVGQRRKY---------LNKALSEKTQFLMAVFQATS 4396
L Q + + D GQ+ Y L ALS+K L+
Sbjct: 4538 LTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPG 4597
Query: 4397 QIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEV 4453
+ + +CL + ++ KS +A L ++YQNE+ L+ Q L+K
Sbjct: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSK 4653
Query: 4454 T--EQEKSEVLGK--LQELQ--SVYDSVLQKCSHRLQELEKN---------LVSRKHFKE 4498
T +Q +E+ G+ ++LQ Y L+ R+ +L L+ + E
Sbjct: 4654 TSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLE 4713
Query: 4499 D-FDKACHWLK--------------QADIVTFPEINLMNESSE--LHTQLAKYQNILEQS 4541
D D L+ Q D + + L+ E H L + ++ +
Sbjct: 4714 DVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQ 4773
Query: 4542 PEYENL----------LLTLQRTGQTILPSLNEVDHSYLSEK------LNALPRQFNVIV 4585
+ EN +L +Q ILPSL + ++ +E+ L RQ + +
Sbjct: 4774 AQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKL 4833
Query: 4586 ALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGC 4645
K+ + E + ++ ++ T S+S +E R+ VE Q
Sbjct: 4834 QSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL--------VERISFYQQIK 4885
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
R I + A L + LN+ K+ S P ++ L + L ++ + + L+
Sbjct: 4886 RNIGGKHARLYQT---LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQAL 4942
Query: 4706 TSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL------QDSGI 4759
+ + QL + L+S + + E++L + L S + D
Sbjct: 4943 LKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKS 5002
Query: 4760 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
LK I + + HL R + ++ + +L + + + + ++ + +
Sbjct: 5003 SLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
Query: 4820 TEMSRSLDWLRRVKAELS--GPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKE 4877
++ + W+ V+ + S V+ + ++ ++K + + E+ I++ ++
Sbjct: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 4878 KEKFT---KAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAA 4934
+ T ++K + L E++ + L + L ++ Q
Sbjct: 5123 LQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
Query: 4935 NDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----P 4990
N+WLE +E L+ V S ++ L + + L+EL TL+ P
Sbjct: 5183 NNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVP 5242
Query: 4991 LIKPTGK--EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND 5048
L++ T ++L QK +S+ + ++ +Q +W Y + +EV +M
Sbjct: 5243 LLEDTASRIDELFQKRSSVLTQVNQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTI 5294
Query: 5049 TEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA 5108
E S S ++ ++L S L+E +L+ ++
Sbjct: 5295 RFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEI 5354
Query: 5109 TLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSA 5168
+ T +RWT++ DQ + + + W ++N +A + Q + K +
Sbjct: 5355 IEEKCQNT-HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLAN 5413
Query: 5169 EKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITA 5228
S L +L + EL+ Q S+L P P E M
Sbjct: 5414 ISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLD--RLPQPAESSTHM----- 5466
Query: 5229 MQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEE 5288
+ L+ ++ K++ + + E V +Q + +LE
Sbjct: 5467 LLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFK------------------DFGVRLES 5508
Query: 5289 LQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELS--LQLAEVALDLKIRD----QI 5342
L+ L+ + + + +E + +L L ++ L EV+L L + D +
Sbjct: 5509 LKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTL 5568
Query: 5343 QDKIKEVEQSKATSQELSRQIQ-------------KLAKDLTTILTKLKAKTDNVVQAKT 5389
Q+ ++ ++ AT+ E ++Q K + L I LK N +
Sbjct: 5569 QNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELL 5628
Query: 5390 DQKVLGEELDGCNSKLMELDAAVQK-----FLEQNGQL-------GKP-LAKKIGKLTEL 5436
+Q+ K++E + ++ + ++ Q+ QL +P + KLT+
Sbjct: 5629 EQQK--------TYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
Query: 5437 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
Q ++ R ++ +++ +E + +++ L SA + +E++
Sbjct: 5681 WQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-------SAVKGQERFS 5733
Query: 5497 LHQT--LLEE--SKEIDSELEAMT--------EKLQYLTSVYCTEKMSQQVAELGRETEE 5544
L+QT L+ E +KEI + T EKL T + E + +++++L ++
Sbjct: 5734 LYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKD 5793
Query: 5545 LRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5604
+ + ++ Q + + E ++K+L++ L+ +A P L E L + + L
Sbjct: 5794 MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKEL 5850
Query: 5605 LSEME 5609
+ E+E
Sbjct: 5851 IKELE 5855
Score = 117 bits (292), Expect = 7e-25
Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)
Query: 1244 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1303
Y+ +K +LI +Q+ +I + Q + QK + + + + ++
Sbjct: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
Query: 1304 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1358
A+ + +GE LP +E+ KLE LD G+ R+R + VT + +
Sbjct: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 1359 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1416
+V+ + + +H S +L +++E K F ++ + + +QA + A +P
Sbjct: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
QN++ + + +VK LE+ + ++ + KW+ F N+ +L EK+L
Sbjct: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
Query: 1477 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1536
L ++ ++ + ++E E +L E SF Q + + A+L Q
Sbjct: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
Query: 1537 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1584
G++L C LEG I LS +K + L ++Q S + D+L
Sbjct: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
Query: 1585 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1644
++ +K ++ +++ Q L+++ S I F +++V + S ++ Q
Sbjct: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
Query: 1645 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1704
L KE TA L A + E++ + +T L + K +M+ R + +
Sbjct: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
Query: 1705 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1737
+ ++++ + S +S LLQ + +SL +++ D
Sbjct: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
Query: 1738 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
+ HL +++ +W + ++N++I L+ ++ + + + + W++
Sbjct: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
Query: 1793 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1851
L+T + S++ Q L +D ++ K L L+ L S + LL+
Sbjct: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
Query: 1852 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1910
A +LF++ S V+ + + + LQ + ++ T+ M ++
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 1911 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1957
++ + L ++N ++L+ A S +G K Q + I Q T R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
Query: 1958 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1998
T + ++++ Q+LL KQ EA LA + + + E L
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
Query: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2054
+++DI+E + + T++A Q V ++L S H L +A + +
Sbjct: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
Query: 2055 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2110
+ A E + +++ + V + K LI HE + +L R +Q K L
Sbjct: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
Query: 2111 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2170
+ ++ I+ ++ + A + + T+ SEL+ I ++
Sbjct: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
Query: 2171 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2230
L +KW+ + EK+EE L+V ++ N +P++ E
Sbjct: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
Query: 2231 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2290
++ K E+EV + ++ L + T+ +E P+ + L
Sbjct: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
Query: 2291 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2343
+ ++A + KG + +DFT + +F+ D + L++ + +
Sbjct: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
Query: 2344 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2403
+L + + + EL++++ + + + C A + L +T +K E+V +
Sbjct: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
Query: 2404 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2455
S+ Q S ++ +E +E +++FQ K+ + +VL+A+ LH D
Sbjct: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
Query: 2456 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2508
L N + + + + L + TQ E QT+ A L++ + V ++EQI + +++
Sbjct: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
Query: 2509 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2567
+ KQ ++D + F +++++L W+ +ME + T ++ + +K+ + ++
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
Query: 2568 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2627
+F L ++ D+L + S + A + +L +++ Q+L + +++ +
Sbjct: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
Query: 2628 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2686
+ L++ + ++ W+ I+ L+ + ++KRL++ QD+ +
Sbjct: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
Query: 2687 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
+ + L S N+ IQ +L W +I + S+ + +E W
Sbjct: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
Query: 2743 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+++ ++ E W++S ++ P + VL + L E R +H +
Sbjct: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
Query: 2803 K---SRELYEKTEDESFKDTA 2820
+ + Y + E+ DTA
Sbjct: 6192 QLELINKQYRRLARENRTDTA 6212
Score = 105 bits (262), Expect = 2e-21
Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)
Query: 1218 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1273
+ K T L ++ + SN E +L+ EL + E++L+
Sbjct: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
Query: 1274 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1328
L+ + +H++ + K++ D + + +A G + E L+ L
Sbjct: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1388
+ + + + + ++ L ++ + + L ++ +S ++ L+ S +S++ +L++
Sbjct: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
Query: 1389 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1448
++ E+ + L E + L ++ ++V KLED L+
Sbjct: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
Query: 1449 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1494
M++ ++ S F T S V I +++ L+ + S A+ QI K
Sbjct: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
Query: 1495 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1554
V Q++ ++ ++ ++ + + ++T+++ E+ R+ L+
Sbjct: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
Query: 1555 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1610
L + ++F+EN +++ + + L + S ET + L E + Q ++
Sbjct: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
Query: 1611 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1667
+ + +++V SC + + A L++Q+ + ++ L+ LL H
Sbjct: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
Query: 1668 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1724
++ WLE + + +++S D + + EV ++S + ++
Sbjct: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
Query: 1725 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1780
+ L + + D ++ L Q +++W LP I K + + E+
Sbjct: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 1781 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1834
+ W+ E QT+ E S+ A L +HK+ E++ K+ + + L
Sbjct: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 1835 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1894
+L + + S+ ER + A HL E + + G+L +
Sbjct: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1954
Q +E L++ E+ L+ L + LK + Q+
Sbjct: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
Query: 1955 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2014
+ +L + + I+N L K AL LK+++ + + +ED R D+ K
Sbjct: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
Query: 2015 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2063
+ + Q++ Q ++++QL DE+N + + +K + +V
Sbjct: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
Query: 2064 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2109
+ E E +W+ + +I + +G C + +++ E + + A++ L
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
Query: 2110 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2169
+ A S++ + A K + AK + L N + G +L +E+
Sbjct: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2229
D ++ D++ T + +L S L DRL E ++ +P
Sbjct: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
Query: 2230 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2280
++ +L L+K EFE S+ K+ +RLE L + +L L + + PD
Sbjct: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
Query: 2281 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2336
L + A Q +EH E++ K L D ++ Q N W +L
Sbjct: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
Query: 2337 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2385
C++ NE CE K ++ ++K ++ + +++++ L + Y E E S+
Sbjct: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
Query: 2386 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
+ + QL T+ + FS+ +Q G + R GD
Sbjct: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
Query: 2446 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2495
L + D ++N+ ++D L AV QE +LY H K Q +
Sbjct: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
Query: 2496 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2552
T +A K L D + + + +D + + + EM ++F + E +
Sbjct: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
Query: 2553 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2612
++ I E K+ + ++ + L E + L +L+ E + +L T
Sbjct: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
Query: 2613 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2646
+L R + KE++ +VA+++ E E + + W
Sbjct: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
Query: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2706
+ +++++ + + ++ +EK + + + E +++L G+Q +++SNK
Sbjct: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
Query: 2707 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2763
I +L + + W D++ S V + I Q + + + L W+ ++ ++
Sbjct: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
Query: 2764 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2815
P+ + Q L E+ L ++ + E L+ S +TE +S
Sbjct: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
Query: 2816 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2875
+ T + L ++ +I ++ E+ K+EE + +LD F DWL SA+ +
Sbjct: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
Query: 2876 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2935
++ +++L + + R+I RL+++E + + ++ + + Q +
Sbjct: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
Query: 2936 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2994
++W++ L+ V+ + + F+ Q + E E L QLT +E
Sbjct: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
Query: 2995 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3037
+ D+++ + QEI +QK+EP L + +L EL R+
Sbjct: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
Query: 3038 RDL 3040
+++
Sbjct: 6334 QEV 6336
Score = 98.6 bits (244), Expect = 2e-19
Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)
Query: 488 QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 534
+L D ER H + + + K+E L +Y LS + ES+ + +
Sbjct: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 535 -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 592
+K G+ + L+ S + E ++V +Q K A+M + S + ++++
Sbjct: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807
Query: 593 ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 636
F E + + L + R L+ ++ W+ + ASL+ + +
Sbjct: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867
Query: 637 EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 692
E+ E+ L + + + RN+ + + +N+ + +C E+ + L++Q L
Sbjct: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927
Query: 693 LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 745
LN R + L + Y + + D++ K TL+ + E +S+ L+
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984
Query: 746 FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 805
N+ + ++++++ + A I + HL KE+ + A + L
Sbjct: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042
Query: 806 VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 863
L++ Q +P + +M S+ +++ + + +S + QKH+
Sbjct: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
Query: 864 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 923
E + +++ +QS+ + T K +++T + +++ + +
Sbjct: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159
Query: 924 DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 982
+H+E + + E L L +E L+ PE ++ D + L
Sbjct: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219
Query: 983 NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1013
KA DEL + +L + Q L+ +++ + +
Sbjct: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277
Query: 1014 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1065
+WK L E + +E ++ + S+E R +++ L + EGS + +
Sbjct: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337
Query: 1066 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1125
+E V KG LC ++IEE C H ++ AI +K
Sbjct: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379
Query: 1126 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1181
WK Y++ E ++ + E + + + ++ N E+ + ++E+++ V
Sbjct: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439
Query: 1182 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1238
K E S + RL E S+ L + + K L+ +E E +LS F
Sbjct: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
Query: 1239 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1294
D K ++ + E L ++ +E + L+ AQ + H + +
Sbjct: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558
Query: 1295 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1350
DV + Q + + +T LER E Q + KW
Sbjct: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605
Query: 1351 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1410
Q E L SL LEQ K + ++AE + +
Sbjct: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646
Query: 1411 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1459
Q+ QLL + + KL D + ++ + K +W F
Sbjct: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706
Query: 1460 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1519
++ E L ++T+ L+A++ + Q + I E+++K + + + A
Sbjct: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760
Query: 1520 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1576
+ GE + L + R +L++ + +E + + Q Q E + ++ +
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
Query: 1577 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1626
E + +L V +K S E ++ L +L + LE +L T + R V
Sbjct: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879
Query: 1627 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1684
+ D V ++ L +Q+ED+ R R+ +E+ L W ++ WL + E K
Sbjct: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939
Query: 1685 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1740
DIS + ++I+ LQ + + + + +S +L Q+ + L ++K
Sbjct: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990
Query: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800
+ L ++++RW+ L +I R+ L+ A QQ D+ + + W+ SEL
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
Query: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1853
+ D Q E++ + E Q LQ H A + S+ D+ L A
Sbjct: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099
Query: 1854 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1898
E ++ ++ ++RR + ++ +FL ++ L+ +T
Sbjct: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159
Query: 1899 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1958
NS S+++ + L+ +A + L + + E RT +
Sbjct: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 1959 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2012
Q+ E +R NL Q A+ + F +Q+EE + E I E
Sbjct: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270
Query: 2013 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
++ + ++R N + E+ + +++ L +Q+ QK
Sbjct: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
Score = 91.3 bits (225), Expect = 4e-17
Identities = 427/2312 (18%), Positives = 886/2312 (38%), Gaps = 391/2312 (16%)
Query: 6511 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6566
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
Query: 6567 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6623
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
Query: 6624 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6683
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 6684 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6738
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
Query: 6739 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6798
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
Query: 6799 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6858
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
Query: 6859 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6918
QK E +K + IH LQ G N +T + +S
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 6919 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 6964
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
Query: 6965 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7024
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
Query: 7025 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7083
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
Query: 7084 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7143
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
Query: 7144 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7203
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
Query: 7204 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7260
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
Query: 7261 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7313
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
Query: 7314 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7373
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
Query: 7374 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7430
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
Query: 7431 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7487
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 7488 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7547
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
Query: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7601
+ + + L S LQ + I K + L + A L
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
Query: 7602 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7657
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
Query: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
Query: 7718 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7772
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
Query: 7773 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7829
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
Query: 7830 LAHIE------------------------------------------SELAKPIVYDSCN 7847
L + E +E + I+ +C
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
Query: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7907
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 7908 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 7956
R + I + E +IE + L QK L D S W + + + S
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
Query: 7957 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 7999
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
Query: 8000 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
Query: 8047 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8097
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
Query: 8098 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8140
+ + + + + II++++ L+ C + +R +K
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 8141 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
Query: 8198 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8246
R + + PLE D L LE+ + P E E + +
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
Query: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 8306
+ +G S + +A + L KN + L L + + E+
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLK----KNKESQYCVLRDFQEYLAAVESSMKALLTDKES 2545
Query: 8307 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV---NLHSTE 8363
+ GP LD+ Y+ + + +SI+ K LK + E+L V + E
Sbjct: 2546 L-----KVGP-LDS--VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLE 2597
Query: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8423
+Q + WE ++ Q K Q + ++ +F + +N + DTE L+Q Q+
Sbjct: 2598 SQIKQLEHGWEQVEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ--- 2647
Query: 8424 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKES 8469
LQ+ +LK ++ ++ I L+ +L + + QA+ KE
Sbjct: 2648 -------HLQL-RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
Query: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
++L+D ++ + +W+ LE ++ + +C ++M +L +N+ N +
Sbjct: 2700 KNLEDGINNLKKQWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSI 2754
Query: 8530 PIDSNLDAEILQDHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKE 8585
P+ L +IL K ++ H+ +L Q V SL + L EG+D E
Sbjct: 2755 PL---LPDDILSQIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLE 2809
Query: 8586 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS 8617
+ N+ ++L+ + ++ ++LE L+ S+
Sbjct: 2810 DLR---NQYQMLVLKSTQRSQQLEFKLEERSN 2838
Score = 79.3 bits (194), Expect = 2e-13
Identities = 565/3062 (18%), Positives = 1152/3062 (37%), Gaps = 460/3062 (15%)
Query: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
V L E +Q K G K + +T VA+D EK++ V+ W
Sbjct: 706 VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
Query: 5149 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5205
V ++ +++ L A+ + EL+ E D ++++ Q+S +L
Sbjct: 756 VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
Query: 5206 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5263
+ +Q+ L+ + + D L+++ K++ + K ++ + + + Q S
Sbjct: 814 AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
Query: 5264 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5322
+ + KE L + T + L+ ++ L T ++I+ EE+ + L
Sbjct: 874 PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
Query: 5323 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5382
ELSL + ++ +D++ + ++ D I ++E+ ++L R+ + K L ++
Sbjct: 931 HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
Query: 5383 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5433
+ Q +VL EEL S+ L + + +++ L+ ++ L G
Sbjct: 988 CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
Query: 5434 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5493
T ++ TI +ENR + A + N+ EKA T+ ++ AS LR
Sbjct: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
Query: 5494 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5550
+ ++++E K+ + + ++ E+ + + + ++ E + ++
Sbjct: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
Query: 5551 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5607
+L +LQ + E + + LE + P V R +LKE+ Q L +
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
Query: 5608 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5658
MESL+ ++ V LC S L + + + L A R+ + +Q + +Q
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
Query: 5659 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5692
CN MQ +++Y+ + M H Q E + +ED
Sbjct: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
Query: 5693 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749
++ + +L A ++ +E +K + +I + K K L K M E
Sbjct: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
Query: 5750 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5804
LD + H V + LL ++ E + S+IS
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
Query: 5805 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5863
+ P T +V L + + K H A S ++ G E +
Sbjct: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 5864 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5921
+ + WE K +++E LE ++YQ+ ++T ++ E + L S
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
Query: 5922 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQ-------- 5969
+ + ++AE + + +E L + D+IN++ +L L ++ E P E+
Sbjct: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
Query: 5970 ------------------LALQSTLTVLAERMSTIRMKASGKRQL--LEEKLNDQLEEQR 6009
LAL L L + KA K +L L E+ ++L+E+
Sbjct: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
Query: 6010 Q--EQALQRYRCEADELDSWLLSTKATLD---------TALSPPKEPMDMEAQLMDCQNM 6058
Q EQ + E+ L S++ L+ + ++ + E+
Sbjct: 1687 QVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGS 1746
Query: 6059 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRA--LHDKQ 6116
E+ + + E+LL KA + ++ ++ KL ++ +L+ + + L + Q
Sbjct: 1747 TAELREDLDQAKTQIGMTESLL---KALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQ 1803
Query: 6117 LNM----QGTAQEKEESDVDLTATQSPGVQ---------------EWLAQARTTWTQQRQ 6157
+ +++ ES DL T+ +Q +W + + + +
Sbjct: 1804 IGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFE 1863
Query: 6158 SSLQQQKELEQEL----------------AEQKSLLRSVASR--------------GEEI 6187
SS + +K +EQ+L + S+L+ V G+E
Sbjct: 1864 SS-ETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF 1922
Query: 6188 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE---DQMRMKWESLHQEFSTKQKLLQN 6244
++ + A E D L Q L ++ + + KW+ + +E K +L
Sbjct: 1923 ELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM-EEPGEKTELFCQ 1981
Query: 6245 VLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ 6304
L +++EQ + +L + + Y + T L+D ++S K
Sbjct: 1982 ALARKREQ--FESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLL 2039
Query: 6305 SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMD- 6363
+Q D W+ +++E L V L E + L + K+I + E D
Sbjct: 2040 PTE-DQSFNDLAHDVIHWIKEIKESLMV---LNSSEGKMPLEERIQKIKEIILLKPEGDA 2095
Query: 6364 KNKNLFSQAFPENGDNRDVIEDTLGCLLGRL-SLLDSVVNQRCHQMKERL--QQILNFQN 6420
+ + + QA +++ TL + + + L HQ K L ++ L +
Sbjct: 2096 RIETIMKQA---ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
Query: 6421 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
DL+++ L + + E+ Q++ ++ ++ + + ELK +G+ L
Sbjct: 2153 DLRLMLIELKKKQEAGFALQHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLL 2210
Query: 6481 --VEQPSMQE--LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6536
+ PS E +++ +++ L+ + L+ ++ Y+ + DL L+ +
Sbjct: 2211 ECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSK 2270
Query: 6537 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA--VQKETQFHTE 6594
+ + S K Q +++ + Q LE+ + L + +KI++ A V++ T +
Sbjct: 2271 EF-----VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQ 2325
Query: 6595 LMAQASAVLKRAHKRGVE-------------LEYILETWSHLDE------DQQELSRQLE 6635
+ + + ++ +E L IL++ ++ +E +
Sbjct: 2326 KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSD 2385
Query: 6636 VVESSIPSVGLVEENEDRLIDR---ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6692
V ES+ S + + ED I++ + + + SLN Q + D+ K +
Sbjct: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA-QESMKNTEDERKVNELQNQPL 2444
Query: 6693 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ----SESADLI-HWLQSAKDRL 6747
+L++ L L K+ +L + +K + + +E+ L+ H + + L
Sbjct: 2445 ELDTMLRNE---QLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHL 2501
Query: 6748 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6807
+ Q +T+ + E L F E+ V +SS+K+ L T + L++ +D+ T
Sbjct: 2502 DNLLQALITLKKNKESQYCVLRDFQEYLAAV--ESSMKA--LLTDKESLKVGPLDSVTYL 2557
Query: 6808 SELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKD 6862
++ + + + D L N+ E L H MDK I ++ +E IQK
Sbjct: 2558 DKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKK 2617
Query: 6863 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 6922
+ + Y + K + +I + +Q + L++ S + +
Sbjct: 2618 YS--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALT 2669
Query: 6923 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIG 6981
L A + +L+G +++ + G E E+ + LK +ET E L+ +++I
Sbjct: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI- 2727
Query: 6982 DQASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQ 7012
+ ++N +K+ C+ D I A+++ VE + +
Sbjct: 2728 KKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAE 2787
Query: 7013 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 7072
+ + S + +TL +L + L Q L+ L++ S+ K
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
Query: 7073 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7132
+ E+ +L R+ T + EA L++ LE ++ LQ+ S + L+E
Sbjct: 2848 LMVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE--- 2897
Query: 7133 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY--------KDYSKQC---- 7180
LTN +E+N+ LE +QL++ K QR+ + K C
Sbjct: 2898 -----LTNIYEELNVFERLFLE---DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFH 2949
Query: 7181 --ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHEL 7235
S +Q++ D R LL NK + ++ I + D L + + L ++
Sbjct: 2950 EKTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKV 3004
Query: 7236 GEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEA 7295
+ + D S +Q+ + L + KQ + + Y+ + A++
Sbjct: 3005 FDYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
Query: 7296 WIVE-AEEILQGQDPSHSS---DLSTIQERMEELK---GQMLKFSSMAPDLD------RL 7342
I + E +L+ D S S + + +R+E+ K +++K + D +
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
Query: 7343 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7402
++ NDK K +QN+ +L L + +K ET + L
Sbjct: 3121 LQIKLNAEENDKLYKVLQNM--------------VLELSPKELDEKNCQDKLETSLHVLN 3166
Query: 7403 QTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSI-IIDGQRLLEQGQVDDR 7459
Q + +L + N + H+ ++ E FQ ++++ + ++ I+ QR + D
Sbjct: 3167 QIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASD- 3225
Query: 7460 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 7519
KL + + R +++ RY+E + + ++ L
Sbjct: 3226 --VETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTR--------AVESITSL 3275
Query: 7520 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQ---- 7573
++ IP R + ++ LR+Q TV + L L S EA LQ
Sbjct: 3276 EAIIIPY---RVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYT 3332
Query: 7574 -AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 7632
EL K A E + ++ K + K E+ I +L K+ T + SLP
Sbjct: 3333 LQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLS 3392
Query: 7633 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7692
+ E + K L + + S ++L +L + L + +D L + V L +W
Sbjct: 3393 YREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLS 3452
Query: 7693 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQ 7752
L E EW ++ E+ K+ EW + S+ + I+++ + E+L
Sbjct: 3453 LL-----------EAAKEWEMWCEELKQ--EW--KFVSEEIEREAIILDNLQEEL----- 3492
Query: 7753 EEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK-- 7810
EI+ +E A S+ + + G+ ++ Q LL L+ R++ ++
Sbjct: 3493 PEISKTKE-----------AATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNV 3541
Query: 7811 -------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 7863
ET+ A Q++ L ++ N E +Q ++ E+ +
Sbjct: 3542 PESSGAVETVPAFQEITSMKERCNKLLQKVQK-----------NKELVQTEIQERHSFTK 3590
Query: 7864 DI 7865
+I
Sbjct: 3591 EI 3592
Score = 65.1 bits (157), Expect = 3e-09
Identities = 325/1714 (18%), Positives = 644/1714 (37%), Gaps = 315/1714 (18%)
Query: 6994 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7040
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
Query: 7041 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7100
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
Query: 7101 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7156
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
Query: 7157 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7212
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
Query: 7213 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7272
Q C ++ K L A I + + +C + +
Sbjct: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Query: 7273 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7332
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
Query: 7333 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7386
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
Query: 7387 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7442
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Query: 7443 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7502
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
Query: 7503 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7562
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
Query: 7563 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7622
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
Query: 7623 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7682
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
Query: 7683 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7742
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
Query: 7743 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7801
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
Query: 7802 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7861
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
Query: 7862 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7919
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
Query: 7920 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 7979
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
Query: 7980 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8039
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
Query: 8040 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8099
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
Query: 8100 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8159
++++ P D ++ + + + + + RV+R L
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
Query: 8160 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 8219
AL D R+A LS +P ++LS S Q ++ +V + + +
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQ------VAQENTLTVKN----KEGEIH 1368
Query: 8220 LSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAY-VKLTE----NAIK 8274
L +D + + L D +D + RG D +A+ +KL+E +
Sbjct: 1369 LMKDKAKHLDKCLKMLDMSFKDAE----RG----DDTSCENLLDAFSIKLSETHGYGVQE 1420
Query: 8275 NTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8331
+ ++ LE+ I +L K + D + QI + I K PT P + K ++L
Sbjct: 1421 EFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKKSLIRL--- 1473
Query: 8332 CSSSIDSVKRLEHKLKEEEESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELR 8386
+D + + L+E SLP F + + Q + WE L + L + R
Sbjct: 1474 -DKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGR 1532
Query: 8387 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQ 8441
+ + L+++Q F S L + L EE + LQ + L I IE+ ++ E
Sbjct: 1533 VLELLKQYQNFKSILTT----LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHL 1588
Query: 8442 KAVDHRKAIILSINLC--------SPEFTQAD----------SKESRDLQDRLSQMNGRW 8483
+ VD + ++ P F + ++++ D + L + W
Sbjct: 1589 EVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW 1648
Query: 8484 DRVCSL---LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 8540
D++ +L ++EW + +Q H+++ E+ +R K E+ + +
Sbjct: 1649 DKLFNLKNVIDEW----TEKALQKMELHQLTE------EDRERLKEEL-----QVHEQKT 1693
Query: 8541 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKL 8596
+ +++ +I+ L S++ + LQ M +L E CL + H + L+
Sbjct: 1694 SEFSRRVAEIQFLLQSSEIPL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELRE 1752
Query: 8597 LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 8630
L + I E LL S L ++ +E+
Sbjct: 1753 DLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEI 1786
Score = 41.2 bits (95), Expect = 0.046
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
Query: 8433 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8488
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
Query: 8489 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
L++E L + + + E +LL EN D +VP
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
Query: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8596
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
Query: 8597 LLKEVSRHIKELEKLLDVSSSQQ 8619
LL++ + I+E E L + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
Score = 39.3 bits (90), Expect = 0.17
Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)
Query: 323 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 381
++ + KE++ + + ++L Q ++++L +H V+ M K QIEHL HR
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
Query: 382 DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 438
+ L L A+ KQ + RL W + +K+ + AWL + E V +I++
Sbjct: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
Query: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 498
+++ E+ ++ + N K+ ++ + + + D+L + +R+
Sbjct: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
Query: 499 VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 549
+ + K L+ + + L S L++W+ + S +++ +
Sbjct: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
Query: 550 YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 606
+ + EQ+ + + ++ + A + E +++ + +WRN+
Sbjct: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
Query: 607 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 653
R +EE W ++ + + + WL+ AE+ N SE +AK++ F
Sbjct: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
Query: 654 FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 712
R + + Q +N L + LKQ + N RW L V +
Sbjct: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
Query: 713 MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 771
++E+ ++ + TE +L+ S + ++ L +Q + + + +
Sbjct: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
Query: 772 IITKTAHLITKESP 785
+I LI K P
Sbjct: 6303 LIVFGEQLIQKSEP 6316
Score = 35.4 bits (80), Expect = 2.5
Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)
Query: 1451 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1505
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 6572 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6631
Query: 1506 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1565
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q F
Sbjct: 6632 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6690
Query: 1566 E 1566
+
Sbjct: 6691 Q 6691
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 2055 bits (5324), Expect = 0.0
Identities = 1779/6584 (27%), Positives = 3072/6584 (46%), Gaps = 613/6584 (9%)
Query: 2346 LKKVKDIQK-----ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS 2400
LK KD++K E+ ++ Q+++++ S+ ++ LI K
Sbjct: 733 LKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDT-----------SMEESLKHLIAKGSMFD 781
Query: 2401 QLCSKTQASLQESLEKHFS-ESMQEFQEWFLGAK----------------AAAKESSDRT 2443
+L ++++ LQ ++ S ES Q L AK AA K +D +
Sbjct: 782 ELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDVS 841
Query: 2444 GDSKVLEAKLHDLQNILDS-VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE--QITKAN 2500
D + K+ + Q L+S + Q L G+ + H I+S+ + + KA
Sbjct: 842 PDLDI-RLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV 900
Query: 2501 EEFQAFLKQCLKDKQALQDCASEL-GSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPE 2559
EE + + + +K +L++ + ++ +E H +L+L++ +++ L ++ + +
Sbjct: 901 EELKNNVTEDIK--MSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEK 958
Query: 2560 KKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMT 2619
+ N+ K L+ + + + SEEG C L H +LR
Sbjct: 959 QINKEKK-------LIRRGRTKGLIKEHEACFSEEG---------CLYQLNHHMEVLREL 1002
Query: 2620 KEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILL 2679
E+L S + + L++ Q + +K + + T G
Sbjct: 1003 CEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGGTS-------------- 1048
Query: 2680 MKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVI 2739
K EG + + G + K Q E E +SV ES++
Sbjct: 1049 -KNEGTITTSENRGGDPHSEAPFAKSDN---QPSTEKAMEPTMKFSLASVLRPLQEESIM 1104
Query: 2740 SQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHR 2799
+ DY N L + ++ +EH LQ KF + S S ED + + +
Sbjct: 1105 EK--DYSASINSLLERYDTYRDILEHHLQ-----NNKF----RITSDFSSEEDRSSSCLQ 1153
Query: 2800 LIAKSRELYEKTEDESFKDTAQEELKTQ--FNDIMT--------VAKEKMRKVEEIVKDH 2849
++ + D +K+ LK + NDI KE+ R+++ +
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
Query: 2850 LMYLDA-------VHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGAS 2902
+ L+ V + + L + LH+ + + ++ + DS
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIE 1273
Query: 2903 RLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA--- 2959
+R+E V + M + + ++ V +++ L+ L +A
Sbjct: 1274 ICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLR 1333
Query: 2960 ---LSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDAL 3016
LS + + A Q ++ + +K ++ L++ K + K ++LD
Sbjct: 1334 TAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLD------KCLKMLDMS 1387
Query: 3017 QKAEPRTEDLKSQLNELCRFSRDLS-TYSGKVSGLIKEYNCL---CLQASKGCQNKEQIL 3072
K R +D + N L FS LS T+ V E N L C+ + Q +
Sbjct: 1388 FKDAERGDDTSCE-NLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDV 1446
Query: 3073 QQRFRK---------AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN 3123
Q + K A + ++ L+ + + +++ E++ SL ++ ++ N
Sbjct: 1447 QSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 3124 GQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESAL-------- 3175
Q + ++L + E+ G ++ +++K+ + L QKE ++
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQC-GRVLELLKQYQNFKSILTTLIQKEESVISLQASYM 1565
Query: 3176 --ENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCY 3233
ENLK ++ + E+ E + L +K + V + + Y
Sbjct: 1566 GKENLKKRIAEIEIVKEEFNEHLEVVDK---------------------INQVCKNLQFY 1604
Query: 3234 EPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFS 3293
LN++K + +E +A + + ++L ++ T++ L R +A ++
Sbjct: 1605 ---LNKMKTFEEPPFEKEA---------NIIVDRWLDINEKTEDYYENLGRALALWDKLF 1652
Query: 3294 LGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGES 3353
+ +W A+ ++ + D+ +L+ L V ++K + V +
Sbjct: 1653 NLKNVIDEWTEKALQKMELHQLTEEDRE-------RLKEELQVHEQKTSEFSRRVAEIQF 1705
Query: 3354 VLQNTS-PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWM 3412
+LQ++ P + ++ + + + L+ C + L G+ ++ D + G
Sbjct: 1706 LLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHA-LSGSTAELREDLDQAKTQIGMT 1764
Query: 3413 DSMEANLNES----------ERQHAELRDKTTMLGKAKL-------LNEEVLSYSSLLET 3455
+S+ L+ S E Q L+ K +M+ L+E Y S+ +
Sbjct: 1765 ESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPELSELKKQYESVSDL 1824
Query: 3456 IEVKGAGMTEHYVTQL--ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEV 3513
K + + +H+ L + ++ + + I+ KE SE + Q+ Q
Sbjct: 1825 FNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQ-------- 1876
Query: 3514 WLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL-LNSVLHTREDVIPS--G 3570
KL + LEG + L+ ++ H + L S L +E +
Sbjct: 1877 -------KLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMES 1929
Query: 3571 IPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKT-AEEKKW 3629
I QA + LE Q Q R N K + ME+ ++ + + + A +++
Sbjct: 1930 ICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQ 1989
Query: 3630 HEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3689
E V + ++E G +E + +AT L RYQ LL Q+ E +EEE
Sbjct: 1990 FESVAQLNNSLKEYGFTEEE---------EIIMEATCLMDRYQTLLRQLSE----IEEED 2036
Query: 3690 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3749
+ L + S + + D + K++K ++L E G L
Sbjct: 2037 KLLPTEDQSFNDLAH-------------------DVIHWIKEIKESLMVLNSSE-GKMPL 2076
Query: 3750 KSAREKGERAVKYLEEGEA--ERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFS 3807
+ +K + + EG+A E + K+ L + T T + LHLA +
Sbjct: 2077 EERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQW--DNTLHLASTYL 2134
Query: 3808 DKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEA 3867
+ L + E ++ L E+ ++ L E K + +LQ + + +K ++
Sbjct: 2135 SHQEKL---LLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKK---- 2187
Query: 3868 LLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHL 3927
L+ QD+T K + Q +Y C+ + EE L++K HL
Sbjct: 2188 FLKKAQDLTSLLKELKSQGNYLLECTKNPSFSEEPW--------LEIK----------HL 2229
Query: 3928 QAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPD 3987
L Q + Q Q+L+ +++H S Q + L +
Sbjct: 2230 HESLLQQL------------------QDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKE 2271
Query: 3988 LEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTI 4047
P+ + ++++ + L+ + S+ D + + AK ++Q ++
Sbjct: 2272 FVSFSDKPVDQIAVEEKLQKLQELENRL--------SLQDGTLKKILALAKSVKQNTSSV 2323
Query: 4048 EQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKD- 4106
QK+++ ++IK L+ + +D + +L + K+ +I ++ S K
Sbjct: 2324 GQKIIK--------DDIKSLQCKQ----KDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 4107 -FVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL 4165
F + KQA+ + + E + E+ E EIN D +++ S L L +E +
Sbjct: 2372 KFTLPGREKQAT-SDVQESTQESAAVEKLEEDWEIN--KDSAVEMA-MSKQLSLNAQESM 2427
Query: 4166 QRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLK 4225
+ T D L+ E D + R++ LE ++KL L+ +K AI+ L+
Sbjct: 2428 KNTEDERKVNE-----LQNQPLELDTMLRNE------QLEEIEKLYTQLEAKKAAIKPLE 2476
Query: 4226 DQKQKMIEHLNLDDK-ELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQE 4284
E LN + LV + Q L++L++ I + N E V FQE
Sbjct: 2477 QT-----ECLNKTETGALVLHNIGYSAQH---LDNLLQALITLK-KNKESQYCVLRDFQE 2527
Query: 4285 LMEWAEEQQPNIA---EALKQSPPPDMAQNLLMDHLA-ICSELEAKQMLLKSLIKDADRV 4340
+ E + E+LK P + +D + + +E ++ L +L + +
Sbjct: 2528 YLAAVESSMKALLTDKESLKVGPLDSVTY---LDKIKKFIASIEKEKDSLGNLKIKWENL 2584
Query: 4341 MADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQ 4400
+ ++++++ + + + + ++ E T + V +QQ
Sbjct: 2585 SNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEISLQQ 2644
Query: 4401 HERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-EQEKS 4459
++ + R L + ++ + L+ ++ + L Q MK + E+EK
Sbjct: 2645 QQQHLQLR----LKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK 2700
Query: 4460 EVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEIN 4519
+ + L+ ++++ L +N + + + + W K P I
Sbjct: 2701 NLEDGINNLKKQWETL-----EPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIP 2755
Query: 4520 LMNES--SELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNAL 4577
L+ + S++ + IL + E+L ++ +PSL + S L+ L L
Sbjct: 2756 LLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDK----VPSLTTYEGSDLNNTLEDL 2811
Query: 4578 PRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFL-RMSKVPTDLAVE 4636
Q+ ++V + + +++ + R + ++I + E E + R+ T+ ++
Sbjct: 2812 RNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELK 2871
Query: 4637 EALSLQDGCRAILDEV-AGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQT 4695
+ + L E+ +G+ + EL E + + D++ +L +R++R
Sbjct: 2872 HHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQR-- 2929
Query: 4696 EQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE-ETLPAEEKLKMYHSLAGSL 4754
+++T + + K C+Q + +++EE + E L +E K +L
Sbjct: 2930 -----FIQNTCNEVEHKIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNL 2984
Query: 4755 QDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQ 4814
+D +K + + L D + Q+ Q ++ + E + + ++ +
Sbjct: 2985 KDRLTAIKCCILQVLKLKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEE 3044
Query: 4815 SIDFQTEMS--RSLDWLRR------VKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
+Q +S R++D + +KA S P LN Q + + I K + +E+
Sbjct: 3045 HGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKK 3104
Query: 4867 LRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELS--ELDG-DIQEALRTRQAT 4916
L KEK +L + + L++ + ELS ELD + Q+ L T
Sbjct: 3105 LNENKTFDDSFKEKEILQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHV 3164
Query: 4917 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 4976
L +I SQ Q+ + E+ + + E+ +E + + M
Sbjct: 3165 LNQIKSQLQQPLLI----------NLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEK 3214
Query: 4977 NLEELHSLVATLDPLIKPTGKEDLEQKV-ASLELRSQRMSRDSGAQVDLLQRCTAQWHDY 5035
EE S + ++ ++ EDL+ ++ S++LR+ ++ D + T Y
Sbjct: 3215 QREENSSEASDVETKLREF--EDLQMQLNTSIDLRTNVLN-------DAYENLTR----Y 3261
Query: 5036 QKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKA 5095
++A +E + E + + + + E L + + L S V +++
Sbjct: 3262 KEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTV-------AHIQDLT 3314
Query: 5096 SQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEM 5155
+L + +K L ++ + + + ++ + QE E ++ + + +
Sbjct: 3315 EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTN 3374
Query: 5156 IDQLQDKLPGS-SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAP 5214
+ +++ L S S+ S E L LE V L + L LRQ L +L+
Sbjct: 3375 LSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQ-ILRLLR--LRC 3431
Query: 5215 TPGEEPPLMQEITAMQDRCLNMQE----------KVKTNGKLVKQELKDREMVETQINSV 5264
T + L++ ++A+ ++ L++ E ++K K V +E++ ++ +
Sbjct: 3432 TENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIILDNLQEE 3491
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEK---MAEEQKEKYLGLYTIL 5321
+ +TKE A EEL LL + +N+EK + ++ + +
Sbjct: 3492 LPEISKTKEA---------ATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVP 3542
Query: 5322 PSELSLQLAEVALDL-KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK 5380
S +++ ++ ++++ +++V+++K Q ++ K++ + +
Sbjct: 3543 ESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQT 3602
Query: 5381 TDNVVQ-AKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQ 5439
T + A D E+ + S L + + +E K K +E++
Sbjct: 3603 TTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIME----------KLRIKYSEMYTI 3652
Query: 5440 TIRQAENRLSKLNQAASHLEEY--NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYIL 5497
+ E+++ + +A ++E NE+L+ + + K+ N L+++
Sbjct: 3653 VPAEIESQVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKN 3712
Query: 5498 HQTLLEESKEIDSELEAMTEKLQYLTSVY--CTEKMSQQVAELG-------RETEELRQM 5548
+ E K++ EL+ KL L S E+ Q E ++ +++ Q
Sbjct: 3713 IEKAQEIQKKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQR 3772
Query: 5549 IKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEM 5608
+ R L A M+++ LK +A +E L +P LSH H +
Sbjct: 3773 AECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLANP--ADYDSLRTLSH--HASTVQ 3828
Query: 5609 ESLKPKVQAVQLCQSALRIPED---VVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAA 5665
+L+ Q L S ED + + L + L + + LQ ++ +Q
Sbjct: 3829 MALEDSEQKHNLLHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRM 3888
Query: 5666 VVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIA 5725
E E+K +++ + + K + + +E + E + + I+ ++ IA
Sbjct: 3889 ADDVVAIESEVKSMEKRVSKIKTILLSKEIFDFSPEE---HLKHGEVILENIRPMKKTIA 3945
Query: 5726 SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 5785
+ S L + L L + + L+ V+ T +
Sbjct: 3946 EIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEI 4005
Query: 5786 --LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALS--AERLQTDAA 5841
L + + + +S A + P + Q ++ Q L+
Sbjct: 4006 ENLKQILNNYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVL 4065
Query: 5842 KIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSL 5901
+H QE E P+ T++ G + + SE++ ++ ++ +
Sbjct: 4066 NLHQHLKQEQEGVERDRLPAVTSEEGGVA------ERDASERKLNRRGSMSYLAAVEEEV 4119
Query: 5902 QSISTKMEAIELKLSESPEPGRS---PESQMAEHQALMDEILMLQD---EINELQSSLAE 5955
+ S K + + K SP+ S + M E +A ++Q+ +I+ +S+A+
Sbjct: 4120 EESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQ 4179
Query: 5956 ELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL-LEEKLNDQLEEQRQE--Q 6012
L +S + + +L+ T E +T ++A + L ++E+ R E +
Sbjct: 4180 ILTPDSLNTEQGPECSLRPNQT---EEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTE 4236
Query: 6013 ALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSEL 6072
L + + EL+ WL ++ +E QL+ CQ ML EIE KV L E
Sbjct: 4237 VLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLET 4296
Query: 6073 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6132
++ L T+ EAE L+ KL+ +K +L ++Q L +K Q K+ S+ +
Sbjct: 4297 C---KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPE 4353
Query: 6133 LTATQSPGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQH 6191
P L T Q RQ QQQ+ LE + EQK ++ + +++ Q+
Sbjct: 4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQY 4413
Query: 6192 SAAE--TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQE 6249
+ T+ ++ S E + S + Q KW+ LH E S+K KL L +
Sbjct: 4414 CQHDNDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEP 4473
Query: 6250 QEQVLYSRPNRLLSGVPLYKGDVPTQDK-SAVTSLLDGLNQAFEEVSSQSGGAKRQSIHL 6308
Q S +L V +Y PT ++ T+ L+ L Q + +Q + I+L
Sbjct: 4474 Q----VSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINL 4529
Query: 6309 EQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL 6368
++KL++ S L VEE L + L E+ + E LA ++K++ + K
Sbjct: 4530 DKKLFELFLTLSQCLSSVEEMLEMPR-LYREDGSGQQVHYETLALELKKLYLALSDKKGD 4588
Query: 6369 FSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTS 6428
+A G+N +++ + L L + R +K L ++QN++K L+
Sbjct: 4589 LLKAMTWPGENTNLLLECFDNLQVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQ 4648
Query: 6429 LADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQE 6488
L +K + Q L + Q VAEQ++ L+ ++ + +L+ G++L + +QE
Sbjct: 4649 LIKSKTSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQE 4708
Query: 6489 LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSS 6548
+ KL+D+ D + ++ +R + L+ +SQ + LQ + +L++ G+EK+A S
Sbjct: 4709 VYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKS 4768
Query: 6549 KEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHK 6608
K +Q ++ HK +FQ L + M+L + KI+ +Q F E + + + +++ +
Sbjct: 4769 KVALQAQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQ 4828
Query: 6609 RGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSL 6668
G++L+ +L+ W DE+ L + LE++ S++PSV LVEE E+RL++RI+ YQ +K ++
Sbjct: 4829 CGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNI 4888
Query: 6669 NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR 6728
+LYQ L++GK+L+ S+SC +LE Q+ +L E WLS K+ ELHRL+ +LKH
Sbjct: 4889 GGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLS 4948
Query: 6729 YQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSV 6788
Y +S L WL+S++ L +W +QS+ V Q+L+ +R ++N F EFSKEVD +SSLK++V
Sbjct: 4949 YNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAV 5008
Query: 6789 LSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEV 6848
+S GNQLL LK+ DTATLR+ L++ + +WT L+T +P +QEKLHQLQM+KLPSR AI+E+
Sbjct: 5009 ISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 6849 MSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISS 6908
+SW++ +E+ DED++ + + LQK+K F+++++ KQ VDFVNQS+LQ+S+
Sbjct: 5069 ISWMNNVEHQTS-DEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLST 5127
Query: 6909 QDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFE 6968
DVESKR ++T+FAE LG MN+ W + G++ KIQ LE LLES +E EN +Q L W E
Sbjct: 5128 CDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLE 5187
Query: 6969 TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI 7028
QE+RLK + SVQ L DCQD+E+ + K K +++++Q+ L L ++ +
Sbjct: 5188 AQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTL-ESGAVPLLED 5246
Query: 7029 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLL 7088
S + EL Q +++ V QLK ++SVL +W + +D++N + Y + + +
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 7089 TGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMR 7148
SLE ++ QV+NLQ+LQD+ E E S +K + +L C P V E + + + R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLC-PSVAEIIEEKCQNTHKR 5365
Query: 7149 WNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEV 7208
W + + IA+QLQ +++LLQLW+ Y + + A+ ++QQE + +L + + + + +
Sbjct: 5366 WTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEIL 5425
Query: 7209 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7268
+QD +L + K++ + ++L Q ++S + SL Q LE+
Sbjct: 5426 PPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSL-QRAAYLEKM 5484
Query: 7269 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7328
L + + + ++ F LE+L+ I+ EE L D H + +E +
Sbjct: 5485 LLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL---DRLHQQE----KENPDSFLNH 5537
Query: 7329 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7388
+L ++ +PD++ LNE+ +LPL+D +K +QN+NR W ++ ER S+LQ L ++
Sbjct: 5538 VLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGL-NE 5596
Query: 7389 TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQ 7448
FL CE W++ L + E+ L V+++ + LLEQQ+ +++ +AE+ Q I S +
Sbjct: 5597 KFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSINQTIADSYVTQSL 5656
Query: 7449 RLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL 7508
+LL+ ++++R EF + + L+++WQ ++ +QR+G +D +RQWQ + E L ++L
Sbjct: 5657 QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFL 5716
Query: 7509 VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGA 7568
+ S+L + G L Q R+L E++ KE F R++ + LT+EAG++LLL+ D
Sbjct: 5717 TDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKT 5776
Query: 7569 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7628
+ ++ ++++Q+ WK +L E K+ ++ W++CEK I + +L+ K +
Sbjct: 5777 KESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP 5836
Query: 7629 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7688
LP+ HE+LH E+ KELE ++ SWT +L +L +K L+ ++ +D+ +L E++E L R
Sbjct: 5837 LPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHR 5896
Query: 7689 QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK 7748
QWE+LC ++++R+Q+I +RLN W VF+EKNKELC WL QME+KV Q DI IEEMIEKL+
Sbjct: 5897 QWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQ 5956
Query: 7749 KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK 7808
KD EEI + ENK+QL+QMG++L KAS++S+A+EI+ KL K+NDRWQHL D+I +RVKK
Sbjct: 5957 KDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQHLFDVIGSRVKK 6016
Query: 7809 LKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKH 7868
LKET +QQLDKNMS+LRTWLA IESEL+KP+VYD C+ +EIQ++L EQQ+LQRDIE+H
Sbjct: 6017 LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQH 6076
Query: 7869 STGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWR 7928
S GV SV N+C+VLLHD DACA + ECDSIQQ TR+LDRRWRNICAMSMERR+KIEETWR
Sbjct: 6077 SAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWR 6136
Query: 7929 LWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELI 7988
LWQKFLDDYSRFEDWLKS+ERTAA P+SS V+YT AKEELK+FEAFQRQ+HE LTQLELI
Sbjct: 6137 LWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAFQRQIHERLTQLELI 6196
Query: 7989 NKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDS 8048
NKQYRRLARENRTD+A LKQMVHEGNQRWDNLQ+RVT++LRRL+HF QREEFE R+S
Sbjct: 6197 NKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRHFTNQREEFEGTRES 6256
Query: 8049 ILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8108
ILVWLTEMDLQLTN+EHFSE D K++QL FQQEI+LN NKI+Q+I GEQLI+KSEP
Sbjct: 6257 ILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEP 6316
Query: 8109 LDAAIIEEELDELRRYCQEVFGRVERYHKKLIR-LPLPDDEHDLSDRELELEDSAALSDL 8167
LDA +IE+EL+EL RYCQEVFGRV R+H++L P +DE + S+ E ++ED +
Sbjct: 6317 LDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENETDMEDPREIQTD 6376
Query: 8168 HWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESA 8227
W R S +PSS SL ERSG +TP SVDSIPLEWDH D+
Sbjct: 6377 SWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHTGDVG------ 6426
Query: 8228 MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI 8287
+ EDEEG + +P+SP E+ K GD
Sbjct: 6427 -GSSSHEEDEEGPYYSALSGKSISDGHSWHVPDSPSC----PEHHYKQMEGD-------- 6473
Query: 8288 RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEH 8344
R+ P P T YK G + L + + L
Sbjct: 6474 ---------------------RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNG 6512
Query: 8345 KLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSI 8404
++E+ L G Q +G DRWE++QAQ L +L++KQNL QQ NSD+++I
Sbjct: 6513 NPQQEDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAI 6563
Query: 8405 WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 8464
WL TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q
Sbjct: 6564 TTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQT 6623
Query: 8465 DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRR 8524
+S ES +LQ RL Q++ W+ ++ WRG L+ +LMQCQ FH++S LLL L + R
Sbjct: 6624 ESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFHQLSQNLLLWLASAKNR 6683
Query: 8525 KNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAK 8584
+ + D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+
Sbjct: 6684 RQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAE 6743
Query: 8585 EKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRST 8644
EKVHVI +LK L ++VS + L+ + +Q S S DE+D SG P +
Sbjct: 6744 EKVHVIEKKLKQLREQVS------QDLMALQGTQNPASPLPSFDEVD-SGDQPPATSVPA 6796
Query: 8645 PNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQ 8704
P R K R R+T+G ++ PG R R FL RV+RAALPLQ
Sbjct: 6797 P-RAKQFRA---------------VRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQ 6840
Query: 8705 LLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8748
LLLLLL+ LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 6841 LLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 6884
Score = 600 bits (1547), Expect = e-170
Identities = 1235/6185 (19%), Positives = 2431/6185 (39%), Gaps = 950/6185 (15%)
Query: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
LQ EQE QK+ FT WINS LA+ P V+ DLF D+K G LL LLEVLSGQ+LP ++G
Sbjct: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
Query: 81 RRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYF 140
+ NI AL FL R IKL+NI+ TDI DG PSI+LGL+WTIIL+F
Sbjct: 85 SNTFQCRI--NIEHALTFLRNRS-------IKLINIHVTDIIDGNPSIILGLIWTIILHF 135
Query: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKR--KVTTKIQGNAKKALLKWVQYT 198
IE+L L S V + SS SPP+K+ KV + Q +A+KALL W Q
Sbjct: 136 HIEKLAQTL-SCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQMSARKALLLWAQEQ 194
Query: 199 AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 258
+ V DF SWR+G+AF ++IHA+RP+L+D+++VK RSN++NL +AF IAE EL
Sbjct: 195 CATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAFRIAEQELK 254
Query: 259 IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQN 318
IPRLL+PEDVDV PDEKSIMTYVAQFL++ D + Q + G+ +
Sbjct: 255 IPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVKDAMGWLTLQK---- 310
Query: 319 FKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQP 378
++++ ++ E D KY S F + ++K ++
Sbjct: 311 ---------EKLQKLLKDSEND---------TYFKKYNSLLSFMESFNEEKKSFLDVLSI 352
Query: 379 LHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITV 438
+L D ++++WD + ++ W I+L+ +LP PL AWL E + E+++
Sbjct: 353 KRDLDELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSA 412
Query: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIP-VPPDQLEDMAERFH 497
Q H + IQ K+ K L+ + H + + N +P VPP++LE+M R +
Sbjct: 413 SQDHSQAVTLIQEKMTLFKSLMDRFEHHSNIL-LTFENKDENHLPLVPPNKLEEMKRRIN 471
Query: 498 FVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENS 557
+ + ++ +EF K +L L+ +SKL W IKYG RESVE LL+++ FIE
Sbjct: 472 NI--LEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEK 529
Query: 558 KFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEE 617
+F + + ++Q + E+Y G + + +R + +V+S L++
Sbjct: 530 EFLARLDTSFQ---KCGEIYKNLAGECQNINKQYMMVKSDVCMYRK---NIYNVKSTLQK 583
Query: 618 VISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIET 677
V++ W Y + L+A E+ +K E K+ F L W +H +N+AGNFL+E
Sbjct: 584 VLACWATYVENLRLLRACFEETKK-----EEIKEVPFETLAQWNLEHATLNEAGNFLVEV 638
Query: 678 CDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKK 737
+++V + ++L LN RWR+L + +
Sbjct: 639 SNDVVGSSISKELRRLNKRWRKLVSKTQ-------------------------------- 666
Query: 738 LSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP--QEEGKEMFAT 795
LE MN+ L+I+ +Q P D I++K + S E E +
Sbjct: 667 ----LE---MNLPLMIK-----KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQ 714
Query: 796 MSKLKEQLTKVKECYSPLL---YESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREA 852
K E+ K E ++ L + ++L+ +E E + S D +++ T +E
Sbjct: 715 NIKAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQ----DDVDTSMEESL 770
Query: 853 QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 912
+ EL+A E+ +++ Q++ + +VL Q ++Q +
Sbjct: 771 KHLIAKGSMFDELMARSED------MLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQ 824
Query: 913 VAFQSMVKKTGDWKK--HVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRH 970
+ ++VK K V + + K EES+ ELE + AQ+ L ++ P EL+ +H
Sbjct: 825 I---NVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKH 881
Query: 971 TEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1030
E + + L +LKA +EL + + E + L+E R + +W+ L E ++ LK
Sbjct: 882 KEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLK 941
Query: 1031 IDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090
ID+EK + ++ + ++++E KL+ + ++ +IKEH FS++G + ++++ E
Sbjct: 942 IDIEKGKLSDNILKLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRE 1001
Query: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTN 1150
LC +LP + ++ LK+ I+ + E + S+ I+T+
Sbjct: 1002 LCEELPSQKSQQEVKR----LLKDYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTS 1057
Query: 1151 ETQLKGIKGEA--IDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQ 1208
E + EA + N ++A+E T+ + S VL + E+ +
Sbjct: 1058 ENRGGDPHSEAPFAKSDNQPSTEKAME----------PTMKF--SLASVLRPLQEESIME 1105
Query: 1209 KQGDELAKLSSSFKALVTLLSEVEKMLSN---------------FGDCVQYK----EIVK 1249
K D A ++S + T +E L N C+Q K +++K
Sbjct: 1106 K--DYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQVIK 1163
Query: 1250 NSLE------ELIS--------------------GSKEVQEQAEKILDT--ENLFEAQQL 1281
N + E+IS KE + + + L+T E+L A +L
Sbjct: 1164 NETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTRMESLETALRL 1223
Query: 1282 LLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERR 1341
+L ++ + + + + Q DR ++ LR ++ ++ R E
Sbjct: 1224 VLPVEKASLLLCGSDLPLHKMAIQGFHLIDA--DRIYQHLRNIQDSIAKQIEICNRLEEP 1281
Query: 1342 IQVTLRKWERFETN--KETVVRYLFQ-TGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1398
L++ F+ + + +++Y Q G +H S +L++L L + E
Sbjct: 1282 GNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEP 1341
Query: 1399 IAVQAENLVKEASEIPLGPQNKQ----LLQQQAKSIKEQVKKL----------EDTLEED 1444
+ + + + A E L +NK+ L++ +AK + + +K L +DT E+
Sbjct: 1342 VTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCEN 1401
Query: 1445 IKTMEMVKTKWDH-FGSNFETLSVWITEKEKEL-------NALETSSSAMDMQISQIKV- 1495
+ +K H +G E TE+ K L N L + + QIS+I +
Sbjct: 1402 LLDAFSIKLSETHGYGVQEE-----FTEENKLLEACIFKNNELLKNIQDVQSQISKIGLK 1456
Query: 1496 --TIQEIESKLSSIV--------------GLEEEAQSFAQFVTTGESARIKAKLTQIRRY 1539
T+ ++ + S++ L+E A S F E + + +
Sbjct: 1457 DPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLW 1516
Query: 1540 GEELREHAQCLE--GTILGHLSQQQKFEENLRKI---QQSVSEFEDKLAVPIKICSSATE 1594
+CLE G +L L Q Q F+ L + ++SV + + E
Sbjct: 1517 ENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMGKENLKKRIAE 1576
Query: 1595 TYKVLQEHMDLCQALESLSSAI--TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKE 1652
V +E + + ++ ++ F + K +EA + ++ DI + ++
Sbjct: 1577 IEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTED 1636
Query: 1653 RQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE 1712
L LA W +L + W E+ K ++ DR +++ ELQ+ + +E
Sbjct: 1637 YYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQL-TEEDRERLKEELQVHEQKTSE 1695
Query: 1713 VVSQASFYSKLLQLKESLFSVASKDDVKMMKL-HLEQ--------------LDERWRDLP 1757
+ + LLQ E + + + K+ H+++ E DL
Sbjct: 1696 FSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELREDLD 1755
Query: 1758 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA-------- 1809
Q +I +S++ D L + F+ ++ LQ + ++++Q+
Sbjct: 1756 Q-AKTQIGMTESLLKALSPSDSLEI-FTKLEEIQQQILQQKHSMILLENQIGCLTPELSE 1813
Query: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKL--GSLGRAED-LHLLQGKAEDCFQLFEEASQV 1866
L + + +++ + K + LQ H +KL D ++ ++CF+ E V
Sbjct: 1814 LKKQYESVSDLFNTKKSV--LQDHFSKLLNDQCKNFNDWFSNIKVNLKECFESSETKKSV 1871
Query: 1867 VERRQLALSHLA---------------EFLQSHASLSGILRQLRQTVEATNSMNKNES-- 1909
++ Q L + ++ H + + + V + K ES
Sbjct: 1872 EQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEFELEKMESIC 1931
Query: 1910 DLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERI 1969
K+L D+LQ L+ +L L+ + K G E L + E+
Sbjct: 1932 QARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWK-GMEEPGEKTELFCQALARKREQF 1990
Query: 1970 QNLLGTKQS-------EADALAVLKKAFQDQKEELLKSIEDIEER-----TDKERLKEPT 2017
+++ S E + + + D+ + LL+ + +IEE T+ + +
Sbjct: 1991 ESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLA 2050
Query: 2018 R------QALQQRLRVFNQLEDELNSHEH-----ELCWLKDKAKQ-----IAQKDVAFAP 2061
+ +++ L V N E ++ E E+ LK + + Q + + AP
Sbjct: 2051 HDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETIMKQAESSEAP 2110
Query: 2062 EVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT 2121
V + + + WD+T L + + L K L++ + +
Sbjct: 2111 LVQKTLTDISNQWDNTLHLAS----------TYLSHQEKLLLEGEKYLQSKEDLRLMLIE 2160
Query: 2122 IKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMEST 2181
+K +++ +A +H + K + K F K + L S LK++ S L++ +
Sbjct: 2161 LKKKQEAGFAL-QHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPS 2217
Query: 2182 V--DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLR 2239
+ WL++ + L E++ + Q+ +++ NLD H+R
Sbjct: 2218 FSEEPWLEI-KHLHESL---------------------------LQQLQDSVQNLDGHVR 2249
Query: 2240 AEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
E + + + +L++ +++ + + P Q + +QKL+ +
Sbjct: 2250 ----------EHDSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRL 2299
Query: 2300 EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQ 2359
+ GTLK A + V++ + + K + + C Q KD++ L S
Sbjct: 2300 SLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQ----------KDLENRLASA 2349
Query: 2360 QSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQ-ESLEKHF 2418
+ + LNS+ + S E + T ++ +A S + TQ S E LE+ +
Sbjct: 2350 KQEMECC---LNSILKSKRSTEKKG---KFTLPGREKQATSDVQESTQESAAVEKLEEDW 2403
Query: 2419 SESMQEFQEWFLGAKAA--AKESSDRTGDSKVLEAKLHDLQN---ILDSVSDGQSKLDAV 2473
+ E + + + A+ES T D E K+++LQN LD++ +
Sbjct: 2404 EINKDSAVEMAMSKQLSLNAQESMKNTED----ERKVNELQNQPLELDTMLRNEQ----- 2454
Query: 2474 TQEGQTLYAHLSKQ---IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQ 2530
+E + LY L + I Q + E L Q L + L + +
Sbjct: 2455 LEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKN 2514
Query: 2531 HRKLNLWIHEMEE-----RFNTENLGESKQHIP----EKKNEVHKVEMFLGELLAARESL 2581
+ + +E + + L K+ + + + K++ F+ + ++SL
Sbjct: 2515 KESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSL 2574
Query: 2582 DKLSQRGQLLSEEGHGAGQEGRL----CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALE 2637
L + + LS H + +L QL + + + ++K V E L
Sbjct: 2575 GNLKIKWENLS--NHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLM 2632
Query: 2638 EALQ----SMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGEGEVKLNM 2690
+Q S+ + +Q RL E G++ + + ++KG+ E+++
Sbjct: 2633 NKVQDTEISLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKR 2692
Query: 2691 AIGKGEQALRSSNKEGQRVIQTQLETLKE----------------------VWADIMSSS 2728
G+ E + + ++G ++ Q ETL+ +WA +
Sbjct: 2693 IWGEKE---KKNLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGE 2749
Query: 2729 VHAQSTL--ESVISQ-------WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVL 2779
++ L + ++SQ + + R+ +E E V K+ P E L
Sbjct: 2750 LNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAEEVKDKV-----PSLTTYEGSDL 2804
Query: 2780 LDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES--FKDTAQEELKTQFNDIMTVAKE 2837
+ L+ + ++ + + + +S++L K E+ S F + +L Q ++ + + +
Sbjct: 2805 NNTLEDLRNQ---YQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRV 2861
Query: 2838 KMRKVEEIVKDHLMYLDAVHEFTDWLHSA-KEELHRWSDMSGDSSATQKKLSKIKELIDS 2896
+ E +K H + L+A + + S L +++ + + ++ +++ + +
Sbjct: 2862 ETAATEAELKHHHVTLEASQKELQEIDSGISTHLQELTNIYEELNVFERLF--LEDQLKN 2919
Query: 2897 REIGASRLSR-VESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV 2955
+I +R+ R +++ EV+ C H + AL+ + DS+ + + L V
Sbjct: 2920 LKIRTNRIQRFIQNTCNEVEHK--IKFCRQFHEKTSALQEE----ADSIQRNELLLNQEV 2973
Query: 2956 SQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDA 3015
++ E + L+ L + L +L+ K + I W Q LD
Sbjct: 2974 NKGVKEE------IYNLKDRLTAIKCCI------LQVLKLKKVFDYIGLNWDFSQ--LDQ 3019
Query: 3016 LQ-KAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQ 3074
LQ + + ++L+ ++ +L F + GK L+ + + LQ K + +
Sbjct: 3020 LQTQVFEKEKELEEKIKQLDTFEEE----HGKYQALLSKMRAIDLQIKK--MTEVVLKAP 3073
Query: 3075 RFRKAFRDFQQWLVNAKITTAKCF--DIPQNISEVST--SLQKIQEFLSESENGQHKLNM 3130
R +++ +I AKC +I + ++E T K +E L N + +
Sbjct: 3074 DSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEILQIKLNAEENDKL 3133
Query: 3131 MLSKGELLSTLLTKE-KAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQ-MKDFEVS 3188
++ L KE K Q K+ + S L Q L NL+I+ +++ + +
Sbjct: 3134 YKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQ--PLLINLEIKHIQNEKDN 3191
Query: 3189 AEPIQD--W--------LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI-------- 3230
E Q+ W ++ EK E+S+ D+ K RE + LQ L
Sbjct: 3192 CEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQLNTSIDLRTNVL 3251
Query: 3231 -HCYEPQLNRLKEKAQQLWEGQAASKSF------------------RHRVSQLSSQYLAL 3271
YE L R KE + E + ++ + +L S +
Sbjct: 3252 NDAYE-NLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQEELESTVAHI 3310
Query: 3272 SNLTKEKVS-------------RLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY-CHPT 3317
+LT EK+ L +V++++ K + T+A L++Y C+
Sbjct: 3311 QDLT-EKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQE---TEAERYLENYKCYRK 3366
Query: 3318 SDKSVLDS------------RTLKL---EALLSVKQEKEIQMKMIVTRGESV-------- 3354
++ + + +L L EAL ++Q K + +I T+ E +
Sbjct: 3367 MEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKLRQILRL 3426
Query: 3355 --LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWM 3412
L+ T +GI + + + ++ + W SLL A + E +W + + + + +
Sbjct: 3427 LRLRCTENDGI-CLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIEREAIIL 3485
Query: 3413 DSMEANLNE--------SERQHAELRDKTTMLG----KAKLLNEEVLSYSSLLETI-EVK 3459
D+++ L E + + +EL D G K +LL +L ++ + E
Sbjct: 3486 DNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNVPESS 3545
Query: 3460 GAGMTE---HYVTQLE------LQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA 3510
GA T +T ++ LQ +Q+ +Q +E + +++++ L +Q+ +
Sbjct: 3546 GAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQQTTTS 3605
Query: 3511 FEVWLGQEQ-EKLDQYSVLEGDAHTHETTLRDLQE-LQVHCAEGQALLNSVLHTREDVIP 3568
F+ Q+ EK +Q+ L+ + T ++ E L++ +E ++ + + ++ +
Sbjct: 3606 FQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQVEECR 3665
Query: 3569 SGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-- 3626
+ +++ + + +Y R + + N L +E+ QQ + ++ A+E
Sbjct: 3666 KALEDIDEKISNEVLKSSPSY-----AMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ 3720
Query: 3627 KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLT-SRYQALLLQVLEQIKFL 3685
KK +E+ + ++ E+ + Q+I+++ ++ + +YQ + + + L
Sbjct: 3721 KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL 3780
Query: 3686 EEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKG 3745
+ +EE L S W +T N A D + T + T+++ L+D E+
Sbjct: 3781 NKATVKMEEYSDLLKSTEAWIENTSHLLANPA-DYDSLRT--LSHHASTVQMALEDSEQK 3837
Query: 3746 HSLLKSA-REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAK 3804
H+LL S + + ++ + E + L + I + Q+ L + + +++
Sbjct: 3838 HNLLHSIFMDLEDLSIIF----ETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVV 3893
Query: 3805 EFSDKCKALTQWIAEYQEILHVPE----EPKMELYEKKAQLSKYKSLQQT---VLSHEPS 3857
+ K++ + +++ + IL E P+ L + L + +++T ++S++
Sbjct: 3894 AIESEVKSMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVE 3953
Query: 3858 VKSVREKGEAL------LELVQDVTLKDKIDQLQSD-YQDLCSIGKAMMEEIAGFEDRLN 3910
++ + + L +L+QD+ L + + Q Q++ + + EEI + LN
Sbjct: 3954 LRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILN 4013
Query: 3911 N--LQMKGDTLIGQCADHLQ------AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH 3962
N Q + + AD L ++++ + + Q +D + +T ++Q L+
Sbjct: 4014 NYSAQFSLEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQ 4073
Query: 3963 EL--------------QKHVSRQDTLQQ------CQAWLSAVQPDL-------------- 3988
E + V+ +D ++ ++L+AV+ ++
Sbjct: 4074 EQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKA 4133
Query: 3989 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4048
EPSPQ S + K ++ RA + + N+ + D TEQ E
Sbjct: 4134 EPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPE 4193
Query: 4049 QKL------------VQAQNL----TQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL 4092
L ++A L QG E + K+ + + L K + +EL
Sbjct: 4194 CSLRPNQTEEGTTPPIEADTLDSSDAQGGLEPRVEKTR-----PEPTEVLHACKTQVAEL 4248
Query: 4093 EL-----NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQW 4147
EL N+A + D + L+ + ++ ++ EHK + L +
Sbjct: 4249 ELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEI----------EHK-VAFLLETC 4297
Query: 4148 LDLCRQSNNLCLQREEDLQRTRDYHDC-MNVVEVFLEKFTTEWDNLARSDAESTAVHLEA 4206
D N E L C + V++ L++ +E + S H EA
Sbjct: 4298 KDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEA 4357
Query: 4207 LKKLALA-----LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQL---- 4257
L+ + L+ + ER Q+Q+++E ++ K+ +K + ++ W Q
Sbjct: 4358 LQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHD 4417
Query: 4258 EDLIKRKIQVSVTNLEELNVVQS----RFQELMEWA---EEQQPNIAEALKQSPPPDMAQ 4310
D + + + E +V S + Q +W E I L Q P ++
Sbjct: 4418 NDTTQESSASNQASSPENDVPDSILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVST 4477
Query: 4311 NL-------------------------LMDHLAICSELEAKQMLLKSLIKDADRVMADLG 4345
N+ L D S L+ ++ + + + D+ + +L
Sbjct: 4478 NMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELF 4537
Query: 4346 LNERQVIQKALSDAQSHVNCLSDLVGQRRKY---------LNKALSEKTQFLMAVFQATS 4396
L Q + + D GQ+ Y L ALS+K L+
Sbjct: 4538 LTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPG 4597
Query: 4397 QIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASL---KTYQNEVTGLWAQGRELMKEV 4453
+ + +CL + ++ KS +A L ++YQNE+ L+ Q L+K
Sbjct: 4598 ENTNLLLECFDNLQVCLEHTQAAAVCRS-KSLKAGLDYNRSYQNEIKRLYHQ---LIKSK 4653
Query: 4454 T--EQEKSEVLGK--LQELQ--SVYDSVLQKCSHRLQELEKN---------LVSRKHFKE 4498
T +Q +E+ G+ ++LQ Y L+ R+ +L L+ + E
Sbjct: 4654 TSLQQSLNEISGQSVAEQLQKADAYTVELENAESRVAKLRDEGERLHLPYALLQEVYKLE 4713
Query: 4499 D-FDKACHWLK--------------QADIVTFPEINLMNESSE--LHTQLAKYQNILEQS 4541
D D L+ Q D + + L+ E H L + ++ +
Sbjct: 4714 DVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQ 4773
Query: 4542 PEYENL----------LLTLQRTGQTILPSLNEVDHSYLSEK------LNALPRQFNVIV 4585
+ EN +L +Q ILPSL + ++ +E+ L RQ + +
Sbjct: 4774 AQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKL 4833
Query: 4586 ALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGC 4645
K+ + E + ++ ++ T S+S +E R+ VE Q
Sbjct: 4834 QSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERL--------VERISFYQQIK 4885
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
R I + A L + LN+ K+ S P ++ L + L ++ + + L+
Sbjct: 4886 RNIGGKHARLYQT---LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQAL 4942
Query: 4706 TSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSL------QDSGI 4759
+ + QL + L+S + + E++L + L S + D
Sbjct: 4943 LKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKS 5002
Query: 4760 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
LK I + + HL R + ++ + +L + + + + ++ + +
Sbjct: 5003 SLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSR 5062
Query: 4820 TEMSRSLDWLRRVKAELS--GPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKE 4877
++ + W+ V+ + S V+ + ++ ++K + + E+ I++ ++
Sbjct: 5063 KAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 4878 KEKFT---KAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAA 4934
+ T ++K + L E++ + L + L ++ Q
Sbjct: 5123 LQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQIL 5182
Query: 4935 NDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----P 4990
N+WLE +E L+ V S ++ L + + L+EL TL+ P
Sbjct: 5183 NNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGAVP 5242
Query: 4991 LIKPTGK--EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMND 5048
L++ T ++L QK +S+ + ++ +Q +W Y + +EV +M
Sbjct: 5243 LLEDTASRIDELFQKRSSVLTQVNQLKTS-------MQSVLQEWKIYDQLYDEV-NMMTI 5294
Query: 5049 TEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKA 5108
E S S ++ ++L S L+E +L+ ++
Sbjct: 5295 RFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEI 5354
Query: 5109 TLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSA 5168
+ T +RWT++ DQ + + + W ++N +A + Q + K +
Sbjct: 5355 IEEKCQNT-HKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLAN 5413
Query: 5169 EKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITA 5228
S L +L + EL+ Q S+L P P E M
Sbjct: 5414 ISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLD--RLPQPAESSTHM----- 5466
Query: 5229 MQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEE 5288
+ L+ ++ K++ + + E V +Q + +LE
Sbjct: 5467 LLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFK------------------DFGVRLES 5508
Query: 5289 LQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELS--LQLAEVALDLKIRD----QI 5342
L+ L+ + + + +E + +L L ++ L EV+L L + D +
Sbjct: 5509 LKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTL 5568
Query: 5343 QDKIKEVEQSKATSQELSRQIQ-------------KLAKDLTTILTKLKAKTDNVVQAKT 5389
Q+ ++ ++ AT+ E ++Q K + L I LK N +
Sbjct: 5569 QNMNRQWIRATATALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELL 5628
Query: 5390 DQKVLGEELDGCNSKLMELDAAVQK-----FLEQNGQL-------GKP-LAKKIGKLTEL 5436
+Q+ K++E + ++ + ++ Q+ QL +P + KLT+
Sbjct: 5629 EQQK--------TYKMLEAEVSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDR 5680
Query: 5437 HQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
Q ++ R ++ +++ +E + +++ L SA + +E++
Sbjct: 5681 WQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTSHLL-------SAVKGQERFS 5733
Query: 5497 LHQT--LLEE--SKEIDSELEAMT--------EKLQYLTSVYCTEKMSQQVAELGRETEE 5544
L+QT L+ E +KEI + T EKL T + E + +++++L ++
Sbjct: 5734 LYQTRSLIHELKNKEIHFQRRRTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKD 5793
Query: 5545 LRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHL 5604
+ + ++ Q + + E ++K+L++ L+ +A P L E L + + L
Sbjct: 5794 MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDP---LPELHEDLHNEKEL 5850
Query: 5605 LSEME 5609
+ E+E
Sbjct: 5851 IKELE 5855
Score = 117 bits (292), Expect = 7e-25
Identities = 313/1701 (18%), Positives = 680/1701 (39%), Gaps = 250/1701 (14%)
Query: 1244 YKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQI 1303
Y+ +K +LI +Q+ +I + Q + QK + + + + ++
Sbjct: 4638 YQNEIKRLYHQLIKSKTSLQQSLNEI--------SGQSVAEQLQKADAYTVELENAESRV 4689
Query: 1304 AQAQ-QGEG-GLPDRGHEELRKLESTLD---GLERSRERQERRIQVTLRKWERFETNKET 1358
A+ + +GE LP +E+ KLE LD G+ R+R + VT + +
Sbjct: 4690 AKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 1359 VVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKR--TESIAVQAENLVKEASEIPLG 1416
+V+ + + +H S +L +++E K F ++ + + +QA + A +P
Sbjct: 4750 LVK-IGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYS----AKILPSL 4804
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
QN++ + + +VK LE+ + ++ + KW+ F N+ +L EK+L
Sbjct: 4805 LQNRETFWAEQVT---EVKILEEKSRQCGMKLQSLLQKWEEFDENYASL-------EKDL 4854
Query: 1477 NALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQI 1536
L ++ ++ + ++E E +L E SF Q + + A+L Q
Sbjct: 4855 EILISTLPSVSL--------VEETEERLV-------ERISFYQQIKRNIGGK-HARLYQT 4898
Query: 1537 RRYGEELREHAQC--LEGTILG----HLSQQQKFEENLRKIQQ------SVSEFEDKLAV 1584
G++L C LEG I LS +K + L ++Q S + D+L
Sbjct: 4899 LNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTK 4958
Query: 1585 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1644
++ +K ++ +++ Q L+++ S I F +++V + S ++ Q
Sbjct: 4959 WLESSQHTLNYWK--EQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQ-- 5014
Query: 1645 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQ 1704
L KE TA L A + E++ + +T L + K +M+ R + +
Sbjct: 5015 --LLHLKETDTA--TLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEMIS 5070
Query: 1705 LIQALQNEVVSQASFYSK--------LLQ------------------LKESLFSVASKD- 1737
+ ++++ + S +S LLQ + +SL +++ D
Sbjct: 5071 WMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSLLQLSTCDV 5130
Query: 1738 -----DVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
+ HL +++ +W + ++N++I L+ ++ + + + + W++
Sbjct: 5131 ESKRYERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQE 5190
Query: 1793 SELQTTSEI-SIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQG 1851
L+T + S++ Q L +D ++ K L L+ L S + LL+
Sbjct: 5191 ERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKALDELKQSYLTLESGA----VPLLED 5246
Query: 1852 KAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQ-TVEATNSMNKNESD 1910
A +LF++ S V+ + + + LQ + ++ T+ M ++
Sbjct: 5247 TASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPV 5306
Query: 1911 LIEKD-LNDALQNAKALESAAVSLDGILSKAQYHLK------------IGSSEQRTSCRA 1957
++ + L ++N ++L+ A S +G K Q + I Q T R
Sbjct: 5307 VLSLETLRCQVENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRW 5366
Query: 1958 TA--DQLCGEVERIQNLLGT---------------KQSEA--DALAVLKKAFQDQKEELL 1998
T + ++++ Q+LL KQ EA LA + + + E L
Sbjct: 5367 TQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILP 5426
Query: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELC----WLKDKAKQIAQ 2054
+++DI+E + + T++A Q V ++L S H L +A + +
Sbjct: 5427 PALQDIKEL---QHDVQKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEK 5483
Query: 2055 KDVAFAPEVDREINRLE---VTWDDTKRLI-HENQGQCCGLIDLMREYQNLKSAVSKVLE 2110
+ A E + +++ + V + K LI HE + +L R +Q K L
Sbjct: 5484 MLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE-------NLDRLHQQEKENPDSFLN 5536
Query: 2111 NASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSD 2170
+ ++ I+ ++ + A + + T+ SEL+ I ++
Sbjct: 5537 HVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATATALERCSELQGIGLNE 5596
Query: 2171 FSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAEN 2230
L +KW+ + EK+EE L+V ++ N +P++ E
Sbjct: 5597 KFLY------CCEKWIQLLEKIEE---ALKVDVA-----------------NSLPELLEQ 5630
Query: 2231 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ 2290
++ K E+EV + ++ L + T+ +E P+ + L
Sbjct: 5631 ----------QKTYKMLEAEVSINQTIADSYVTQSLQLLDTTE-IENRPEFITEFSKLTD 5679
Query: 2291 KLEHAKEITEVAKGTL-------KDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETC 2343
+ ++A + KG + +DFT + +F+ D + L++ + +
Sbjct: 5680 RWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDTS--------HLLSAVKGQER 5731
Query: 2344 EALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLC 2403
+L + + + EL++++ + + + C A + L +T +K E+V +
Sbjct: 5732 FSLYQTRSLIHELKNKEIHF----QRRRTTCALTLEAGEKLL---LTTDLKTKESVGRRI 5784
Query: 2404 SKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK-------LH-D 2455
S+ Q S ++ +E +E +++FQ K+ + +VL+A+ LH D
Sbjct: 5785 SQLQDSWKD-MEPQLAEMIKQFQSTVETWDQCEKKIKELKSRLQVLKAQSEDPLPELHED 5843
Query: 2456 LQNILDSVSDGQSKLDAVTQ---EGQTLYAHLSKQI----VSSIQEQITKANEEFQAFLK 2508
L N + + + + L + TQ E QT+ A L++ + V ++EQI + +++
Sbjct: 5844 LHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCL 5903
Query: 2509 QCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER-FNTENLGESKQHIPEKKNEVHKV 2567
+ KQ ++D + F +++++L W+ +ME + T ++ + +K+ + ++
Sbjct: 5904 RVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKVLQTADISIEEMIEKLQKDCMEEI 5963
Query: 2568 EMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ 2627
+F L ++ D+L + S + A + +L +++ Q+L + +++ +
Sbjct: 5964 NLFSENKLQLKQMGDQLIKA----SNKSRAAEIDDKL-NKINDRWQHLFDVIGSRVKKLK 6018
Query: 2628 VALQEHEALEEALQSMWFWVKAIQDRLAC-AESTLGSKDTLEKRLSQIQDILLMKGEGEV 2686
+ L++ + ++ W+ I+ L+ + ++KRL++ QD+ +
Sbjct: 6019 ETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSA 6078
Query: 2687 KLNMAIGKGEQALRSS----NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
+ + L S N+ IQ +L W +I + S+ + +E W
Sbjct: 6079 GVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLW 6138
Query: 2743 NDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+++ ++ E W++S ++ P + VL + L E R +H +
Sbjct: 6139 QKFLDDYSRFEDWLKSAERTAACPNSSE-------VLYTSAKEELKRFEAFQRQIHERLT 6191
Query: 2803 K---SRELYEKTEDESFKDTA 2820
+ + Y + E+ DTA
Sbjct: 6192 QLELINKQYRRLARENRTDTA 6212
Score = 105 bits (262), Expect = 2e-21
Identities = 352/1983 (17%), Positives = 759/1983 (38%), Gaps = 301/1983 (15%)
Query: 1218 SSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLE----ELISGSKEVQEQAEKILDTE 1273
+ K T L ++ + SN E +L+ EL + E++L+
Sbjct: 4495 TEELKTYTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMP 4554
Query: 1274 NLF--EAQQLLLHHQQ---KTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1328
L+ + +H++ + K++ D + + +A G + E L+ L
Sbjct: 4555 RLYREDGSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCL 4614
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1388
+ + + + + ++ L ++ + + L ++ +S ++ L+ S +S++ +L++
Sbjct: 4615 EHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQK 4674
Query: 1389 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1448
++ E+ + L E + L ++ ++V KLED L+
Sbjct: 4675 ADAYTVELENAESRVAKLRDEGERLHL-----------PYALLQEVYKLEDVLDS---MW 4720
Query: 1449 EMVKTKWDHFGSNFETLS------------VWITEKEKELNALETSSS--AMDMQISQIK 1494
M++ ++ S F T S V I +++ L+ + S A+ QI K
Sbjct: 4721 GMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHK 4780
Query: 1495 VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTI 1554
V Q++ ++ ++ ++ + + ++T+++ E+ R+ L+
Sbjct: 4781 VFFQKL---VADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSL- 4836
Query: 1555 LGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALE---- 1610
L + ++F+EN +++ + + L + S ET + L E + Q ++
Sbjct: 4837 ---LQKWEEFDENYASLEKDL----EILISTLPSVSLVEETEERLVERISFYQQIKRNIG 4889
Query: 1611 SLSSAITAFSASARKVVNRDSCVQ---EAAALQQQYEDILRRAKERQTALENLLAHWQRL 1667
+ + +++V SC + + A L++Q+ + ++ L+ LL H
Sbjct: 4890 GKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSY 4949
Query: 1668 EKELSSFLTWLERGEAKAS---SPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1724
++ WLE + + +++S D + + EV ++S + ++
Sbjct: 4950 NRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLKTAVI 5009
Query: 1725 QLKESLFSVASKDDVKMMKLHLEQLDERWR----DLPQIINKRINFLQSVVAEHQQFDEL 1780
+ L + + D ++ L Q +++W LP I K + + E+
Sbjct: 5010 SIGNQLLHL-KETDTATLRASLAQFEQKWTMLITQLPDIQEKLHQLQMEKLPSRKAITEM 5068
Query: 1781 LLSFSVWIKLFLSELQTTSEISIMDHQVA------LTRHKDHAAEVESKKGELQSLQGHL 1834
+ W+ E QT+ E S+ A L +HK+ E++ K+ + + L
Sbjct: 5069 IS----WMNNV--EHQTSDEDSVHSPSSASQVKHLLQKHKEFRMEMDYKQWIVDFVNQSL 5122
Query: 1835 AKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1894
+L + + S+ ER + A HL E + + G+L +
Sbjct: 5123 LQLSTC--------------------DVESKRYERTEFA-EHLGEMNRQWHRVHGMLNRK 5161
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1954
Q +E L++ E+ L+ L + LK + Q+
Sbjct: 5162 IQHLE------------------QLLESITESENKIQILNNWLEAQEERLK---TLQKPE 5200
Query: 1955 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2014
+ +L + + I+N L K AL LK+++ + + +ED R D+ K
Sbjct: 5201 SVISVQKLLLDCQDIENQLAIKSK---ALDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257
Query: 2015 -----------EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEV 2063
+ + Q++ Q ++++QL DE+N + + +K + +V
Sbjct: 5258 RSSVLTQVNQLKTSMQSVLQEWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQV 5317
Query: 2064 DR------EINRLEVTWDDTKRLIHENQGQCCGLIDLMRE--------YQNLKSAVSKVL 2109
+ E E +W+ + +I + +G C + +++ E + + A++ L
Sbjct: 5318 ENLQSLQDEAESSEGSWEKLQEVIGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQL 5377
Query: 2110 ENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSS 2169
+ A S++ + A K + AK + L N + G +L +E+
Sbjct: 5378 QKAQSLLQLWKAYSNAHGEAAARLKQQEAKFQQ------LANISMSGNNL-AEILPPALQ 5430
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2229
D ++ D++ T + +L S L DRL E ++ +P
Sbjct: 5431 DIKELQHDVQKTKEAFLQNSSVL----DRLP-------------QPAESSTHMLLPGPLH 5473
Query: 2230 NISNLDNHLRAEELLK--EFE---SEVKNKALRLEELHSKV----NDLKELTKNLETPPD 2280
++ +L L+K EFE S+ K+ +RLE L + +L L + + PD
Sbjct: 5474 SLQRAA-YLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENLDRLHQQEKENPD 5532
Query: 2281 --LQFIEADLMQK--LEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2336
L + A Q +EH E++ K L D ++ Q N W +L
Sbjct: 5533 SFLNHVLALTAQSPDIEHLNEVS--LKLPLSDVAVKTLQ-----NMNRQWIRATATALER 5585
Query: 2337 CAQ------NET----CEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE-SL 2385
C++ NE CE K ++ ++K ++ + +++++ L + Y E E S+
Sbjct: 5586 CSELQGIGLNEKFLYCCE--KWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAEVSI 5643
Query: 2386 GRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
+ + QL T+ + FS+ +Q G + R GD
Sbjct: 5644 NQTIADSYVTQSL--QLLDTTEIENRPEFITEFSKLTDRWQNAVQGVR-------QRKGD 5694
Query: 2446 SKVLEAKLHD----LQNILDSVSDGQSKLDAVT-QEGQTLYA-----HLSKQIVSSIQEQ 2495
L + D ++N+ ++D L AV QE +LY H K Q +
Sbjct: 5695 VDGLVRQWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRR 5754
Query: 2496 ITKANEEFQAFLKQCLK-DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT--ENLGE 2552
T +A K L D + + + +D + + + EM ++F + E +
Sbjct: 5755 RTTCALTLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQ 5814
Query: 2553 SKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSH 2612
++ I E K+ + ++ + L E + L +L+ E + +L T
Sbjct: 5815 CEKKIKELKSRLQVLKAQSEDPLP--ELHEDLHNEKELIKELEQSLASWTQNLKELQTMK 5872
Query: 2613 QNLLR--------MTKEKLRSC---------QVALQEHE---------ALEEALQSMWFW 2646
+L R + KE++ +VA+++ E E + + W
Sbjct: 5873 ADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAW 5932
Query: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEG 2706
+ +++++ + + ++ +EK + + + E +++L G+Q +++SNK
Sbjct: 5933 LVQMENKVL-QTADISIEEMIEKLQKDCMEEINLFSENKLQLKQM---GDQLIKASNKSR 5988
Query: 2707 QRVIQTQLETLKEVWA---DIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2763
I +L + + W D++ S V + I Q + + + L W+ ++ ++
Sbjct: 5989 AAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLD---KNMSNLRTWLARIESEL 6045
Query: 2764 EHPL--------QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDES 2815
P+ + Q L E+ L ++ + E L+ S +TE +S
Sbjct: 6046 SKPVVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDS 6105
Query: 2816 FKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD 2875
+ T + L ++ +I ++ E+ K+EE + +LD F DWL SA+ +
Sbjct: 6106 IQQTTRS-LDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNS 6164
Query: 2876 MSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRA 2935
++ +++L + + R+I RL+++E + + ++ + + Q +
Sbjct: 6165 SEVLYTSAKEELKRFEAF--QRQI-HERLTQLELINKQYRRLARENRTDTASRLKQMVHE 6221
Query: 2936 DWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLE- 2994
++W++ L+ V+ + + F+ Q + E E L QLT +E
Sbjct: 6222 GNQRWDN--------LQRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEH 6273
Query: 2995 --GKNTDEEIVECWHKGQEIL--------------DALQKAEPRTEDL-KSQLNELCRFS 3037
+ D+++ + QEI +QK+EP L + +L EL R+
Sbjct: 6274 FSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYC 6333
Query: 3038 RDL 3040
+++
Sbjct: 6334 QEV 6336
Score = 98.6 bits (244), Expect = 2e-19
Identities = 314/1723 (18%), Positives = 639/1723 (37%), Gaps = 255/1723 (14%)
Query: 488 QLEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAESKLKSWI----- 534
+L D ER H + + + K+E L +Y LS + ES+ + +
Sbjct: 4691 KLRDEGERLHLPYALLQ-EVYKLEDVLDSMWGMLRARYTELSSPFVTESQQDALLQGMVE 4749
Query: 535 -IKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMK- 592
+K G+ + L+ S + E ++V +Q K A+M + S + ++++
Sbjct: 4750 LVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQ--KLVADMLLIQAYSAKILPSLLQN 4807
Query: 593 ---FMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQ-------------AWL 636
F E + + L + R L+ ++ W+ + ASL+ + +
Sbjct: 4808 RETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILISTLPSVSLV 4867
Query: 637 EDAEKMLNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIE-TCDEMVSR--DLKQQLLL 692
E+ E+ L + + + RN+ + + +N+ + +C E+ + L++Q L
Sbjct: 4868 EETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAKLEEQWLS 4927
Query: 693 LN-------GRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVS 745
LN R + L + Y + + D++ K TL+ + E +S+ L+
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNR--DSDQLTKWLESSQHTLN-YWKEQSLNVSQDLDTI 4984
Query: 746 FMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTK 805
N+ + ++++++ + A I + HL KE+ + A + L
Sbjct: 4985 RSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHL--KETDTATLRASLAQFEQKWTMLIT 5042
Query: 806 VKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSAL--FKQKHQ 863
L++ Q +P + +M S+ +++ + + +S + QKH+
Sbjct: 5043 QLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHK 5102
Query: 864 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTG 923
E + +++ +QS+ + T K +++T + +++ + +
Sbjct: 5103 EF---RMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLN 5159
Query: 924 DWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD-QRVL 982
+H+E + + E L L +E L+ PE ++ D + L
Sbjct: 5160 RKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQL 5219
Query: 983 NAFLKACDEL-----------------------------TDILPEQEQQGLQEAVRKLHK 1013
KA DEL + +L + Q L+ +++ + +
Sbjct: 5220 AIKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQ--LKTSMQSVLQ 5277
Query: 1014 QWK---DLQGEAPYHLLHLKIDVEKNR-FLASVEECRTELDRETKLMPQ----EGSEKII 1065
+WK L E + +E ++ + S+E R +++ L + EGS + +
Sbjct: 5278 EWKIYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKL 5337
Query: 1066 KEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRK 1125
+E V KG LC ++IEE C H ++ AI +K
Sbjct: 5338 QE--VIGKLKG---LCPSVAEIIEEKC-------------QNTHKRWTQVNQAIADQLQK 5379
Query: 1126 LMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV----KRAVEEIRNGV 1181
WK Y++ E ++ + E + + + ++ N E+ + ++E+++ V
Sbjct: 5380 AQSLLQLWKAYSNAHGEAAARLKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDV 5439
Query: 1182 TKRGETL---SWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1238
K E S + RL E S+ L + + K L+ +E E +LS F
Sbjct: 5440 QKTKEAFLQNSSVLDRLPQPAESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQF 5499
Query: 1239 GD----CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISA 1294
D K ++ + E L ++ +E + L+ AQ + H + +
Sbjct: 5500 KDFGVRLESLKGLIMHEEENLDRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVS-LKL 5558
Query: 1295 KKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ----ERRIQVTLRKWE 1350
DV + Q + + +T LER E Q + KW
Sbjct: 5559 PLSDVAVKTLQNMNRQW------------IRATATALERCSELQGIGLNEKFLYCCEKW- 5605
Query: 1351 RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEA 1410
Q E L SL LEQ K + ++AE + +
Sbjct: 5606 -------------IQLLEKIEEALKVDVANSLPELLEQQKTYK------MLEAEVSINQT 5646
Query: 1411 SEIPLGPQNKQLLQ----QQAKSIKEQVKKLEDTLEEDIKTMEMVK-------TKWDHFG 1459
Q+ QLL + + KL D + ++ + K +W F
Sbjct: 5647 IADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVRQWQDFT 5706
Query: 1460 SNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQ 1519
++ E L ++T+ L+A++ + Q + I E+++K + + + A
Sbjct: 5707 TSVENLFRFLTDTSHLLSAVKGQER---FSLYQTRSLIHELKNK---EIHFQRRRTTCAL 5760
Query: 1520 FVTTGESARIKAKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVS 1576
+ GE + L + R +L++ + +E + + Q Q E + ++ +
Sbjct: 5761 TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK 5820
Query: 1577 EFEDKLAVPIKICSS--ATETYKVLQEHMDLCQALE--------SLSSAITAFSASARKV 1626
E + +L V +K S E ++ L +L + LE +L T + R V
Sbjct: 5821 ELKSRLQV-LKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHV 5879
Query: 1627 VNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAK 1684
+ D V ++ L +Q+ED+ R R+ +E+ L W ++ WL + E K
Sbjct: 5880 LVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENK 5939
Query: 1685 ASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS----KLLQLKESLFSVASKDDVK 1740
DIS + ++I+ LQ + + + + +S +L Q+ + L ++K
Sbjct: 5940 VLQ-TADISIE--------EMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAA 5990
Query: 1741 MMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE 1800
+ L ++++RW+ L +I R+ L+ A QQ D+ + + W+ SEL
Sbjct: 5991 EIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVV 6050
Query: 1801 ISIMDHQVALTRHKDHAAEVESKKGELQSLQ----GHLAKLGSLGRAEDLHLLQGKA--- 1853
+ D Q E++ + E Q LQ H A + S+ D+ L A
Sbjct: 6051 YDVCDDQ-----------EIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACAN 6099
Query: 1854 EDCFQLFEEASQVVERRQLALSHLA---------------EFLQSHASLSGILRQLRQTV 1898
E ++ ++ ++RR + ++ +FL ++ L+ +T
Sbjct: 6100 ETECDSIQQTTRSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTA 6159
Query: 1899 EATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRAT 1958
NS S+++ + L+ +A + L + + E RT +
Sbjct: 6160 ACPNS-----SEVLYTSAKEELKRFEAFQRQIHERLTQLELINKQYRRLARENRTDTASR 6214
Query: 1959 ADQLCGE-VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDI-----EERTDKER 2012
Q+ E +R NL Q A+ + F +Q+EE + E I E
Sbjct: 6215 LKQMVHEGNQRWDNL----QRRVTAVLRRLRHFTNQREEFEGTRESILVWLTEMDLQLTN 6270
Query: 2013 LKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
++ + ++R N + E+ + +++ L +Q+ QK
Sbjct: 6271 VEHFSESDADDKMRQLNGFQQEITLNTNKIDQLIVFGEQLIQK 6313
Score = 91.3 bits (225), Expect = 4e-17
Identities = 427/2312 (18%), Positives = 886/2312 (38%), Gaps = 391/2312 (16%)
Query: 6511 NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE----EIQQLLDKHKEYFQGL 6566
NQN+ ++E+ ++ TGQ K+A D + ++ E E + +LD+
Sbjct: 713 NQNIKAGEKHEKENEEF-----TGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDD------ 761
Query: 6567 ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR---GVELEYILETWSHL 6623
+T + + + K + F ELMA++ +L+ + +++L T
Sbjct: 762 ------VDTSMEESLKHLIAKGSMFD-ELMARSEDMLQMDIQNISSQESFQHVLTTGLQA 814
Query: 6624 DEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGK 6683
+ + Q+ VV+ L + + D +D + + L Y + Q+L +
Sbjct: 815 KIQEAKEKVQINVVKLIAALKNLTDVSPD--LDIRLKMEESQKELESYMMRAQQLLGQRE 872
Query: 6684 RLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTR-----YQSESADLIH 6738
S +L S+ + +SNT ++K L +E + + T + +S D+
Sbjct: 873 ------SPGELISKHKEA--LIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCA 924
Query: 6739 WLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRL 6798
+S L + QQ + + E + D++ L+ K+++ + L +
Sbjct: 925 KWESLHHELSLYVQQ-LKIDIEKGKLSDNI---LKLEKQINKEKKL-------------I 967
Query: 6799 KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV 6858
++ T L E S+ L + E L +L ++LPS+ + EV L+++
Sbjct: 968 RRGRTKGLIKEHEACFSE-EGCLYQLNHHMEVLREL-CEELPSQKSQQEVKR---LLKDY 1022
Query: 6859 IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6918
QK E +K + IH LQ G N +T + +S
Sbjct: 1023 EQKIERLLKCA---SEIHMTLQPTAG-GTSKNEGTITTSENRGGDPHSEAPFAKSDNQPS 1078
Query: 6919 TDFAEQLGAMNKSWQILQGLVTEKIQ------LLEGLLESWSEY--------ENNVQCLK 6964
T+ A + +L+ L E I + LLE + Y +NN +
Sbjct: 1079 TEKAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRIT 1138
Query: 6965 TWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED 7024
+ F ++E R + +Q L D Q +++ A+ KE E I + + K+
Sbjct: 1139 SDFSSEEDR--------SSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKP 1190
Query: 7025 VSSIVMSTLRELG-QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7083
TL+E + L+ + L+ L+ VL K + S L + ++
Sbjct: 1191 FVIKERDTLKERERELQMTLNTRMESLETALRLVLPV---EKASLLLCGSDLPLHKMAIQ 1247
Query: 7084 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7143
F L+ +A ++ +L+N+QD + KQ + N +LKE HP + N +
Sbjct: 1248 GFHLI----DADRIY-QHLRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIIL 1302
Query: 7144 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7203
+ ++ + + + KAL +D+ + E T+ +A++ +
Sbjct: 1303 KYKTQFEGMNHRVQRSEDTLKAL-------EDFLASLRTAKLSAEPVTD---LSASDTQV 1352
Query: 7204 ADDEVATWIQDCND--LLKGLGTVKDSLFFLHELG-EQLKQQVDASAASAIQSDQLSLSQ 7260
A + T + L+K D + ++ + ++ D S + + + + LS+
Sbjct: 1353 AQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAERGDDTSCENLLDAFSIKLSE 1412
Query: 7261 -HLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS------HSS 7313
H +++ ++ L+A + K+++ +++ I + + +DP+
Sbjct: 1413 THGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKK 1468
Query: 7314 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQT 7373
L + + ++E + + MA L + G +N ++ + L + + ++
Sbjct: 1469 SLIRLDKVLDEYEEEKRHLQEMANSLPHFKD-GREKTVN-QQCQNTVVLWENTKALVTEC 1526
Query: 7374 TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY---QHLLEQQRAHELFQ 7430
E+ ++ L Q+Q F ++ + L+Q E+ + + + +Y ++L ++ E+ +
Sbjct: 1527 LEQCGRVLELLKQYQNF----KSILTTLIQKEESV-ISLQASYMGKENLKKRIAEIEIVK 1581
Query: 7431 AEMFSRQQI---LHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7487
E ++ ++ + + Q L + + + F + ++ ++W + + + +
Sbjct: 1582 EEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENL 1641
Query: 7488 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7547
+ W + + + +W + + L Q T D + KE++ + +Q
Sbjct: 1642 GRALALWDKLFNLKNVIDEWTEKALQ---------KMELHQL-TEEDRERLKEELQVHEQ 1691
Query: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKK------KLAFLL 7601
+ + + L S LQ + I K + L + A L
Sbjct: 1692 KTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELR 1751
Query: 7602 KDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKE----LENAVGSWTDDL 7657
+D ++ + I + L+ S + EE+ + ++ K LEN +G T +L
Sbjct: 1752 EDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQIGCLTPEL 1811
Query: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
++L +++S + N + +LQ + +L + + N+W FS
Sbjct: 1812 SELKKQYESVS--------DLFNTKKSVLQDHFSKLLNDQC-------KNFNDW--FSNI 1854
Query: 7718 NKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQ-----LQQMGERL 7772
L E E+K S +E+ ++KL E + +KI+ L+ + + L
Sbjct: 1855 KVNLKECFESSETKKS------VEQKLQKLSDFLTLE---GRNSKIKQVDSVLKHVKKHL 1905
Query: 7773 AKASHESKASEI---EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 7829
KA + S + E++L K+ + AR K+L+++L + +L + +LR W
Sbjct: 1906 PKAHVKELISWLVGQEFELEKME-------SICQARAKELEDSLQQLLRLQDDHRNLRKW 1958
Query: 7830 LAHIE------------------------------------------SELAKPIVYDSCN 7847
L + E +E + I+ +C
Sbjct: 1959 LTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCL 2018
Query: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDR 7907
+ Q L + E++ + + T S +L ++H + + L+
Sbjct: 2019 MDRYQTLLRQLSEIEEEDKLLPTEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEE 2078
Query: 7908 R---WRNICAMSMERRLKIEETWR--------LWQKFLDDYSRFEDWLKSSERTAAFPSS 7956
R + I + E +IE + L QK L D S W + + + S
Sbjct: 2079 RIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDIS--NQWDNTLHLASTYLSH 2136
Query: 7957 ------SGVIYTVAKE-------ELKKFE----AFQRQVHECLTQLELINKQYRRLAREN 7999
G Y +KE ELKK + A Q + E QL++ K ++
Sbjct: 2137 QEKLLLEGEKYLQSKEDLRLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLKK----- 2191
Query: 8000 RTDSACSLKQMVHEGN-------------QRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
D LK++ +GN + W ++ S+L++L+ + +
Sbjct: 2192 AQDLTSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREH 2251
Query: 8047 DSILVWLTEMDLQLTNI--EHFSECD-------VQAKIKQLKAFQQEISLNHNKIEQIIA 8097
DS V +T+++ L N E S D V+ K+++L+ + +SL +++I+A
Sbjct: 2252 DSYQVCVTDLNTTLDNFSKEFVSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILA 2311
Query: 8098 QGEQLIEKSEPLDAAIIEEELDELR-----------------RYCQEVFGRVERYHKKLI 8140
+ + + + + II++++ L+ C + +R +K
Sbjct: 2312 LAKSVKQNTSSVGQKIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKG 2371
Query: 8141 RLPLPDDEHD-LSDRELELEDSAALSDLH--WHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ LP E SD + ++SAA+ L W + + DS + S LSL+ + +++
Sbjct: 2372 KFTLPGREKQATSDVQESTQESAAVEKLEEDW-EINKDSAVEMAMSKQLSLNAQESMKNT 2430
Query: 8198 RSGRDTPASVDSIPLEWD---------HDYDLSRDLESAMSRALPSEDEE--GQDDKDFY 8246
R + + PLE D L LE+ + P E E + +
Sbjct: 2431 EDERKV-NELQNQPLELDTMLRNEQLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGAL 2489
Query: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTEN 8306
+ +G S + +A + L KN + L L + + E+
Sbjct: 2490 VLHNIGYSAQHLDNLLQALITLK----KNKESQYCVLRDFQEYLAAVESSMKALLTDKES 2545
Query: 8307 IIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV---NLHSTE 8363
+ GP LD+ Y+ + + +SI+ K LK + E+L V + E
Sbjct: 2546 L-----KVGP-LDS--VTYLDKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLE 2597
Query: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLEL 8423
+Q + WE ++ Q K Q + ++ +F + +N + DTE L+Q Q+
Sbjct: 2598 SQIKQLEHGWEQVEQQIQKK---YSQQVVEYDEFTTLMNKV----QDTEISLQQQQQ--- 2647
Query: 8424 STDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEF------TQAD--------SKES 8469
LQ+ +LK ++ ++ I L+ +L + + QA+ KE
Sbjct: 2648 -------HLQL-RLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEK 2699
Query: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
++L+D ++ + +W+ LE ++ + +C ++M +L +N+ N +
Sbjct: 2700 KNLEDGINNLKKQWE----TLEPLHLEAENQIKKCDIRNKMKE-TILWAKNLLGELNPSI 2754
Query: 8530 PIDSNLDAEILQDHHKQLMQIKHE-LLESQLRVASLQDM---SCQLLVNAEGTDCLEAKE 8585
P+ L +IL K ++ H+ +L Q V SL + L EG+D E
Sbjct: 2755 PL---LPDDILSQIRK--CKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLE 2809
Query: 8586 KVHVIGNRLKLLLKEVSRHIKELEKLLDVSSS 8617
+ N+ ++L+ + ++ ++LE L+ S+
Sbjct: 2810 DLR---NQYQMLVLKSTQRSQQLEFKLEERSN 2838
Score = 79.3 bits (194), Expect = 2e-13
Identities = 565/3062 (18%), Positives = 1152/3062 (37%), Gaps = 460/3062 (15%)
Query: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
V L E +Q K G K + +T VA+D EK++ V+ W
Sbjct: 706 VELPENYNQNIKAGEKHEKEN---------EEFTGQLKVAKDVEKLIGQ-VEIWEAEAKS 755
Query: 5149 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ---QQSALGMLRQQTL 5205
V ++ +++ L A+ + EL+ E D ++++ Q+S +L
Sbjct: 756 VLDQDDVDTSMEESLKHLIAKGSMFDELMARSE--DMLQMDIQNISSQESFQHVLTTGLQ 813
Query: 5206 SMLQDGAAPTPGEEPPLMQEITAMQDRC--LNMQEKVKTNGKLVKQELKDREMVETQINS 5263
+ +Q+ L+ + + D L+++ K++ + K ++ + + + Q S
Sbjct: 814 AKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLKMEESQKELESYMMRAQQLLGQRES 873
Query: 5264 VKCWVQETKEYLG-NPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILP 5322
+ + KE L + T + L+ ++ L T ++I+ EE+ + L
Sbjct: 874 PGELISKHKEALIISNTKSLAKYLKAVEELKNNVT---EDIKMSLEEKSRDVCAKWESLH 930
Query: 5323 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTD 5382
ELSL + ++ +D++ + ++ D I ++E+ ++L R+ + K L ++
Sbjct: 931 HELSLYVQQLKIDIE-KGKLSDNILKLEKQINKEKKLIRRGR--TKGLIKEHEACFSEEG 987
Query: 5383 NVVQAKTDQKVLG---EELDGCNSK------LMELDAAVQKFLEQNGQLGKPLAKKIGKL 5433
+ Q +VL EEL S+ L + + +++ L+ ++ L G
Sbjct: 988 CLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIERLLKCASEIHMTLQPTAGG- 1046
Query: 5434 TELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLRE 5493
T ++ TI +ENR + A + N+ EKA T+ ++ AS LR
Sbjct: 1047 TSKNEGTITTSENRGGDPHSEAPFAKSDNQ------PSTEKA---MEPTMKFSLASVLRP 1097
Query: 5494 QYILHQTLLEESKEIDSELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIK 5550
+ ++++E K+ + + ++ E+ + + + ++ E + ++
Sbjct: 1098 --LQEESIME--KDYSASINSLLERYDTYRDILEHHLQNNKFRITSDFSSEEDRSSSCLQ 1153
Query: 5551 IRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV--GRLSLKEQLSHRQHLL-SE 5607
+L +LQ + E + + LE + P V R +LKE+ Q L +
Sbjct: 1154 AKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLKERERELQMTLNTR 1213
Query: 5608 MESLKPKVQAV--------QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQ- 5658
MESL+ ++ V LC S L + + + L A R+ + +Q + +Q
Sbjct: 1214 MESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDAD-RIYQHLRNIQDSIAKQI 1272
Query: 5659 --CN-------------------IMQAAVVQYEQYEQEMKHLQQLIEGAHREIED----- 5692
CN MQ +++Y+ + M H Q E + +ED
Sbjct: 1273 EICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASL 1332
Query: 5693 --KPVATSNIQELQAQISR-HEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749
++ + +L A ++ +E +K + +I + K K L K M E
Sbjct: 1333 RTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMSFKDAE 1392
Query: 5750 VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGE-----EGTNSEISS 5804
LD + H V + LL ++ E + S+IS
Sbjct: 1393 RGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELLKNIQDVQSQISK 1452
Query: 5805 PPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEFYEPGLEPSAT 5863
+ P T +V L + + K H A S ++ G E +
Sbjct: 1453 -IGLKDP-----TVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDGREKTVN 1506
Query: 5864 AKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIE--LKLSESPEP 5921
+ + WE K +++E LE ++YQ+ ++T ++ E + L S
Sbjct: 1507 QQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISLQASYMG 1566
Query: 5922 GRSPESQMAEHQALMDEI---LMLQDEINELQSSLAEEL-VSESCEADPAEQ-------- 5969
+ + ++AE + + +E L + D+IN++ +L L ++ E P E+
Sbjct: 1567 KENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDR 1626
Query: 5970 ------------------LALQSTLTVLAERMSTIRMKASGKRQL--LEEKLNDQLEEQR 6009
LAL L L + KA K +L L E+ ++L+E+
Sbjct: 1627 WLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRERLKEEL 1686
Query: 6010 Q--EQALQRYRCEADELDSWLLSTKATLD---------TALSPPKEPMDMEAQLMDCQNM 6058
Q EQ + E+ L S++ L+ + ++ + E+
Sbjct: 1687 QVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNCHALSGS 1746
Query: 6059 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRA--LHDKQ 6116
E+ + + E+LL KA + ++ ++ KL ++ +L+ + + L + Q
Sbjct: 1747 TAELREDLDQAKTQIGMTESLL---KALSPSDSLEIFTKLEEIQQQILQQKHSMILLENQ 1803
Query: 6117 LNM----QGTAQEKEESDVDLTATQSPGVQ---------------EWLAQARTTWTQQRQ 6157
+ +++ ES DL T+ +Q +W + + + +
Sbjct: 1804 IGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKECFE 1863
Query: 6158 SSLQQQKELEQEL----------------AEQKSLLRSVASR--------------GEEI 6187
SS + +K +EQ+L + S+L+ V G+E
Sbjct: 1864 SS-ETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQEF 1922
Query: 6188 LIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE---DQMRMKWESLHQEFSTKQKLLQN 6244
++ + A E D L Q L ++ + + KW+ + +E K +L
Sbjct: 1923 ELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGM-EEPGEKTELFCQ 1981
Query: 6245 VLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ 6304
L +++EQ + +L + + Y + T L+D ++S K
Sbjct: 1982 ALARKREQ--FESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLL 2039
Query: 6305 SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMD- 6363
+Q D W+ +++E L V L E + L + K+I + E D
Sbjct: 2040 PTE-DQSFNDLAHDVIHWIKEIKESLMV---LNSSEGKMPLEERIQKIKEIILLKPEGDA 2095
Query: 6364 KNKNLFSQAFPENGDNRDVIEDTLGCLLGRL-SLLDSVVNQRCHQMKERL--QQILNFQN 6420
+ + + QA +++ TL + + + L HQ K L ++ L +
Sbjct: 2096 RIETIMKQA---ESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKE 2152
Query: 6421 DLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
DL+++ L + + E+ Q++ ++ ++ + + ELK +G+ L
Sbjct: 2153 DLRLMLIELKKKQEAGFALQHGLQEKKA--QLKIYKKFLKKAQDLTSLLKELKSQGNYLL 2210
Query: 6481 --VEQPSMQE--LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6536
+ PS E +++ +++ L+ + L+ ++ Y+ + DL L+ +
Sbjct: 2211 ECTKNPSFSEEPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSK 2270
Query: 6537 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFA--VQKETQFHTE 6594
+ + S K Q +++ + Q LE+ + L + +KI++ A V++ T +
Sbjct: 2271 EF-----VSFSDKPVDQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQ 2325
Query: 6595 LMAQASAVLKRAHKRGVE-------------LEYILETWSHLDE------DQQELSRQLE 6635
+ + + ++ +E L IL++ ++ +E +
Sbjct: 2326 KIIKDDIKSLQCKQKDLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSD 2385
Query: 6636 VVESSIPSVGLVEENEDRLIDR---ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCS 6692
V ES+ S + + ED I++ + + + SLN Q + D+ K +
Sbjct: 2386 VQESTQESAAVEKLEEDWEINKDSAVEMAMSKQLSLNA-QESMKNTEDERKVNELQNQPL 2444
Query: 6693 DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ----SESADLI-HWLQSAKDRL 6747
+L++ L L K+ +L + +K + + +E+ L+ H + + L
Sbjct: 2445 ELDTMLRNE---QLEEIEKLYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHL 2501
Query: 6748 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6807
+ Q +T+ + E L F E+ V +SS+K+ L T + L++ +D+ T
Sbjct: 2502 DNLLQALITLKKNKESQYCVLRDFQEYLAAV--ESSMKA--LLTDKESLKVGPLDSVTYL 2557
Query: 6808 SELSRIDS---QWTDLLTNIPAVQEKL--HQLQMDKLPSRHAISEVMSWISLMENVIQKD 6862
++ + + + D L N+ E L H MDK I ++ +E IQK
Sbjct: 2558 DKIKKFIASIEKEKDSLGNLKIKWENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKK 2617
Query: 6863 EDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFA 6922
+ + Y + K + +I + +Q + L++ S + +
Sbjct: 2618 YS--QQVVEYDEFTTLMNKVQDTEISLQQQQQHLQ------LRLKSPEERAGNQSMIALT 2669
Query: 6923 EQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK-RLKQQHRIG 6981
L A + +L+G +++ + G E E+ + LK +ET E L+ +++I
Sbjct: 2670 TDLQATKHGFSVLKGQAELQMKRIWGEKEK-KNLEDGINNLKKQWETLEPLHLEAENQI- 2727
Query: 6982 DQASVQNALKD-----------------------------CQDLEDLIKAKEKEVEKIEQ 7012
+ ++N +K+ C+ D I A+++ VE + +
Sbjct: 2728 KKCDIRNKMKETILWAKNLLGELNPSIPLLPDDILSQIRKCKVTHDGILARQQSVESLAE 2787
Query: 7013 NGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKIN 7072
+ + S + +TL +L + L Q L+ L++ S+ K
Sbjct: 2788 EVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIRKFQ 2847
Query: 7073 SYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHP 7132
+ E+ +L R+ T + EA L++ LE ++ LQ+ S + L+E
Sbjct: 2848 LMVQESE-TLIIPRVETAATEA------ELKHHHVTLEASQKELQEIDSGISTHLQE--- 2897
Query: 7133 PVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRY--------KDYSKQC---- 7180
LTN +E+N+ LE +QL++ K QR+ + K C
Sbjct: 2898 -----LTNIYEELNVFERLFLE---DQLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFH 2949
Query: 7181 --ASTVQQQED---RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHEL 7235
S +Q++ D R LL NK + ++ I + D L + + L ++
Sbjct: 2950 EKTSALQEEADSIQRNELLLNQEVNKGVKEE-----IYNLKDRLTAIKCCILQVLKLKKV 3004
Query: 7236 GEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEA 7295
+ + D S +Q+ + L + KQ + + Y+ + A++
Sbjct: 3005 FDYIGLNWDFSQLDQLQTQVFEKEKEL----EEKIKQLDTFEEEHGKYQALLSKMRAIDL 3060
Query: 7296 WIVE-AEEILQGQDPSHSS---DLSTIQERMEELK---GQMLKFSSMAPDLD------RL 7342
I + E +L+ D S S + + +R+E+ K +++K + D +
Sbjct: 3061 QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI 3120
Query: 7343 NELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7402
++ NDK K +QN+ +L L + +K ET + L
Sbjct: 3121 LQIKLNAEENDKLYKVLQNM--------------VLELSPKELDEKNCQDKLETSLHVLN 3166
Query: 7403 QTEQKLAVEISGNYQ--HLLEQQRAHELFQAEMFSRQQILHSI-IIDGQRLLEQGQVDDR 7459
Q + +L + N + H+ ++ E FQ ++++ + ++ I+ QR + D
Sbjct: 3167 QIKSQLQQPLLINLEIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASD- 3225
Query: 7460 DEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGL 7519
KL + + R +++ RY+E + + ++ L
Sbjct: 3226 --VETKLREFEDLQMQLNTSIDLRTNVLNDAYENLTRYKEAVTR--------AVESITSL 3275
Query: 7520 GSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL--LSADSGAEAALQ---- 7573
++ IP R + ++ LR+Q TV + L L S EA LQ
Sbjct: 3276 EAIIIPY---RVDVGNPEESLEMPLRKQEELESTVAHIQDLTEKLGMISSPEAKLQLQYT 3332
Query: 7574 -AELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDH 7632
EL K A E + ++ K + K E+ I +L K+ T + SLP
Sbjct: 3333 LQELVSKNSAMKEAFKAQETEAERYLENYKCYRKMEEDIYTNLSKMETVLGQSMSSLPLS 3392
Query: 7633 HEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEE 7692
+ E + K L + + S ++L +L + L + +D L + V L +W
Sbjct: 3393 YREALERLEQSKALVSNLISTKEELMKLRQILRLLRLRCTENDGICLLKIVSALWEKWLS 3452
Query: 7693 LCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQ 7752
L E EW ++ E+ K+ EW + S+ + I+++ + E+L
Sbjct: 3453 LL-----------EAAKEWEMWCEELKQ--EW--KFVSEEIEREAIILDNLQEEL----- 3492
Query: 7753 EEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK-- 7810
EI+ +E A S+ + + G+ ++ Q LL L+ R++ ++
Sbjct: 3493 PEISKTKE-----------AATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQNV 3541
Query: 7811 -------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR 7863
ET+ A Q++ L ++ N E +Q ++ E+ +
Sbjct: 3542 PESSGAVETVPAFQEITSMKERCNKLLQKVQK-----------NKELVQTEIQERHSFTK 3590
Query: 7864 DI 7865
+I
Sbjct: 3591 EI 3592
Score = 65.1 bits (157), Expect = 3e-09
Identities = 325/1714 (18%), Positives = 644/1714 (37%), Gaps = 315/1714 (18%)
Query: 6994 QDLEDLIKAKEKEVEKIEQNGL-ALIQNKKEDVSSI--VMSTLRELGQ----------TW 7040
+ L+ L+K E + + N L + +++ E+ S V+S R+L + W
Sbjct: 311 EKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELDKDHLQLREAW 370
Query: 7041 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVD 7100
LDH + KI L L A+ + LM+ S S+ + ++ +Q ++
Sbjct: 371 DGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDH--SQAVTLIQEKMT 428
Query: 7101 NLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEE----I 7156
++L D E L +T + E H P+ N L+E+ R NN+LE+ +
Sbjct: 429 LFKSLMDRFEHHSNIL-----LTFENKDENHLPLVP--PNKLEEMKRRINNILEKKFILL 481
Query: 7157 AEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDE----VATWI 7212
E +L L K SK ++ + ELL +K I + E + T
Sbjct: 482 LEFHYYKCLVLGLVDEVK--SKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSF 539
Query: 7213 QDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQ 7272
Q C ++ K L A I + + +C + +
Sbjct: 540 QKCGEIYKNL----------------------AGECQNINKQYMMVKSDVCMYRKNIYNV 577
Query: 7273 QTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKF 7332
+++LQ + + T+ ++L L A E T +E ++E+ + L
Sbjct: 578 KSTLQKVLACWATYVENLRLLRACFEE-----------------TKKEEIKEVPFETLAQ 620
Query: 7333 SSMAPDLDRLNELGYRLPLNDKEI------KRMQNLNRHWSLISSQTTERFSKLQSFLLQ 7386
++ + LNE G L ++ K ++ LN+ W + S+T + Q
Sbjct: 621 WNL--EHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRKLVSKTQLEMNLPLMIKKQ 678
Query: 7387 HQTFLEKCETWM----EFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHS 7442
Q + + + V+ ++VE+ NY ++ HE E + ++
Sbjct: 679 DQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGEKHEKENEEFTGQLKVAK- 737
Query: 7443 IIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAE 7502
D ++L+ Q ++ W+ + + ++D Q M E
Sbjct: 738 ---DVEKLIGQVEI----------------WEA------EAKSVLD----QDDVDTSMEE 768
Query: 7503 KLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLL 7562
L+ + + S +FDE+ + + L+ I + E+ + +L
Sbjct: 769 SLKHLIAKGS-------------------MFDELMARSEDMLQMDIQNISSQESFQHVLT 809
Query: 7563 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7622
+ LQA++ E +EK + ++L K L + D + K + +S ++L ++
Sbjct: 810 T-------GLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDIRLK-MEESQKELESYM 861
Query: 7623 KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNER 7682
+ Q L ++ K E + S T L + + L ++ D L E+
Sbjct: 862 MRAQQLLGQRES---PGELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEK 918
Query: 7683 VELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEE 7742
+ +WE L H+LSL QQ+ + EK K L + + ++E ++++ ++
Sbjct: 919 SRDVCAKWESLHHELSLYVQQL-------KIDIEKGK-LSDNILKLEKQINKEKKLIRRG 970
Query: 7743 MIEKLKKDYQEEIAIAQENKI-QLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL 7801
+ L K++ E ++E + QL E L + E + + + ++ ++ ++ ++
Sbjct: 971 RTKGLIKEH--EACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLKDYEQKIER 1028
Query: 7802 IAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7861
+ +K E + +Q S + E+ P +SE K + Q
Sbjct: 1029 L---LKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDP------HSEAPFAKSDNQPST 1079
Query: 7862 QRDIE-KHSTGVASVLN-LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMER 7919
++ +E +ASVL L E + + D A SI D +R+I +E
Sbjct: 1080 EKAMEPTMKFSLASVLRPLQEESIMEKDYSA------SINSLLERYD-TYRDI----LEH 1128
Query: 7920 RLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVH 7979
L+ + + D+S ED +SS A + VI K+FE ++
Sbjct: 1129 HLQNNKF-----RITSDFSSEED--RSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLE 1181
Query: 7980 ECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQR 8039
+ I K + R+ + L+ + N R ++L+ + +L
Sbjct: 1182 NHVND---IKKPFVIKERDTLKERERELQMTL---NTRMESLETALRLVL---------- 1225
Query: 8040 EEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQG 8099
+ S+L+ +++ L I+ F D + L+ Q I+ ++ G
Sbjct: 1226 ---PVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPG 1282
Query: 8100 EQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8159
++++ P D ++ + + + + + RV+R L
Sbjct: 1283 NFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTL-------------------- 1322
Query: 8160 DSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYD 8219
AL D R+A LS +P ++LS S Q ++ +V + + +
Sbjct: 1323 --KALEDFLASLRTAK--LSAEPVTDLSASDTQ------VAQENTLTVKN----KEGEIH 1368
Query: 8220 LSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAY-VKLTE----NAIK 8274
L +D + + L D +D + RG D +A+ +KL+E +
Sbjct: 1369 LMKDKAKHLDKCLKMLDMSFKDAE----RG----DDTSCENLLDAFSIKLSETHGYGVQE 1420
Query: 8275 NTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8331
+ ++ LE+ I +L K + D + QI + I K PT P + K ++L
Sbjct: 1421 EFTEENKLLEACIFKNNELLKNIQDVQSQISK----IGLKDPTVPAVKHRKKSLIRL--- 1473
Query: 8332 CSSSIDSVKRLEHKLKEEEESLPGFVN--LHSTETQTAGVIDRWE---LLQAQALSKELR 8386
+D + + L+E SLP F + + Q + WE L + L + R
Sbjct: 1474 -DKVLDEYEEEKRHLQEMANSLPHFKDGREKTVNQQCQNTVVLWENTKALVTECLEQCGR 1532
Query: 8387 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ-----RLELSTDIQTIELQIKKLKELQ 8441
+ + L+++Q F S L + L EE + LQ + L I IE+ ++ E
Sbjct: 1533 VLELLKQYQNFKSILTT----LIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHL 1588
Query: 8442 KAVDHRKAIILSINLC--------SPEFTQAD----------SKESRDLQDRLSQMNGRW 8483
+ VD + ++ P F + ++++ D + L + W
Sbjct: 1589 EVVDKINQVCKNLQFYLNKMKTFEEPPFEKEANIIVDRWLDINEKTEDYYENLGRALALW 1648
Query: 8484 DRVCSL---LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEIL 8540
D++ +L ++EW + +Q H+++ E+ +R K E+ + +
Sbjct: 1649 DKLFNLKNVIDEW----TEKALQKMELHQLTE------EDRERLKEEL-----QVHEQKT 1693
Query: 8541 QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTD-CLEAKEKVHVIGN---RLKL 8596
+ +++ +I+ L S++ + LQ M +L E CL + H + L+
Sbjct: 1694 SEFSRRVAEIQFLLQSSEIPL-ELQVMESSILNKMEHVQKCLTGESNCHALSGSTAELRE 1752
Query: 8597 LLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 8630
L + I E LL S L ++ +E+
Sbjct: 1753 DLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEI 1786
Score = 41.2 bits (95), Expect = 0.046
Identities = 59/263 (22%), Positives = 113/263 (42%), Gaps = 43/263 (16%)
Query: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
W LQ + L K L+ +N ++++NS L+ + ++ EE+ L L + D+ ++
Sbjct: 305 WLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESF---NEEKKSFLDVLSIKRDLDELDK 361
Query: 8433 QIKKLKELQKAVDHR-KAIILSINLCSP---EFTQADSKESRDLQDRLSQMNGRWDRVCS 8488
+L+E +DH+ A + +N P T+A +E +L D + + +
Sbjct: 362 DHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAVT 421
Query: 8489 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
L++E L + + + E +LL EN D +VP
Sbjct: 422 LIQEKMTLFKSLMDR----FEHHSNILLTFENKDENHLPLVP------------------ 459
Query: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCL------EAKEKVHV----IGNR--LKL 8596
++L E + R+ ++ + LL+ CL E K K+ + G+R ++L
Sbjct: 460 --PNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVEL 517
Query: 8597 LLKEVSRHIKELEKLLDVSSSQQ 8619
LL++ + I+E E L + +S Q
Sbjct: 518 LLEDWHKFIEEKEFLARLDTSFQ 540
Score = 39.3 bits (90), Expect = 0.17
Identities = 89/494 (18%), Positives = 194/494 (39%), Gaps = 55/494 (11%)
Query: 323 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRK-QIEHLIQPLHR 381
++ + KE++ + + ++L Q ++++L +H V+ M K QIEHL HR
Sbjct: 5847 EKELIKELEQSLASWTQNLKELQTMKADLT------RHVLVEDVMVLKEQIEHL----HR 5896
Query: 382 DGK-LSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAE--VALREEITV 438
+ L L A+ KQ + RL W + +K+ + AWL + E V +I++
Sbjct: 5897 QWEDLCLRVAIRKQE---IEDRLNTWVVFNEKNKE-----LCAWLVQMENKVLQTADISI 5948
Query: 439 QQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHF 498
+++ E+ ++ + N K+ ++ + + + D+L + +R+
Sbjct: 5949 EEMIEKLQKDCMEEINLFSE---NKLQLKQMGDQLIKASNKSRAAEIDDKLNKINDRWQH 6005
Query: 499 VSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESV---------EQLLQN 549
+ + K L+ + + L S L++W+ + S +++ +
Sbjct: 6006 LFDVIGSRVKK---LKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQKR 6062
Query: 550 YVSFIENSKFFEQYEVTYQILKQTAEMYVK---ADGSVEEAENVMKFMNETTAQWRNLSV 606
+ + EQ+ + + ++ + A + E +++ + +WRN+
Sbjct: 6063 LAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICA 6122
Query: 607 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML---NQSE----NAKKD------F 653
R +EE W ++ + + + WL+ AE+ N SE +AK++ F
Sbjct: 6123 MSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFEAF 6182
Query: 654 FRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQ-YAQADE 712
R + + Q +N L + LKQ + N RW L V +
Sbjct: 6183 QRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRLRH 6242
Query: 713 MDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQY-K 771
++E+ ++ + TE +L+ S + ++ L +Q + + + +
Sbjct: 6243 FTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKIDQ 6302
Query: 772 IITKTAHLITKESP 785
+I LI K P
Sbjct: 6303 LIVFGEQLIQKSEP 6316
Score = 35.4 bits (80), Expect = 2.5
Identities = 26/121 (21%), Positives = 55/121 (45%), Gaps = 6/121 (4%)
Query: 1451 VKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKV-TIQEI----ESKLS 1505
+K S+ ++ W+ + E EL L+ + D+Q +++V +QEI ++ +
Sbjct: 6549 IKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKA 6608
Query: 1506 SIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFE 1565
+V + ++ F Q + ES ++++L Q+ E + G + L Q Q F
Sbjct: 6609 LVVSVNVSSKEFLQ-TESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQDFH 6667
Query: 1566 E 1566
+
Sbjct: 6668 Q 6668
>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform 3
[Homo sapiens]
Length = 982
Score = 1947 bits (5044), Expect = 0.0
Identities = 982/982 (100%), Positives = 982/982 (100%)
Query: 7768 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 7827
MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR
Sbjct: 1 MGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLR 60
Query: 7828 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 7887
TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 7888 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 7947
ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
Query: 7948 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 8007
ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL
Sbjct: 181 ERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL 240
Query: 8008 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 8067
KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS
Sbjct: 241 KQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS 300
Query: 8068 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 8127
ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
Query: 8128 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 8187
VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS
Sbjct: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
Query: 8188 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8247
LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL
Sbjct: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
Query: 8248 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 8307
RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI
Sbjct: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 540
Query: 8308 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 8367
IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA
Sbjct: 541 IRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTA 600
Query: 8368 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8427
GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI
Sbjct: 601 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
Query: 8428 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8487
QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC
Sbjct: 661 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
Query: 8488 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8547
SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL
Sbjct: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
Query: 8548 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8607
MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
Query: 8608 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8667
LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP
Sbjct: 841 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 900
Query: 8668 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 8727
HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA
Sbjct: 901 HSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCA 960
Query: 8728 LSNNFARSFHPMLRYTNGPPPL 8749
LSNNFARSFHPMLRYTNGPPPL
Sbjct: 961 LSNNFARSFHPMLRYTNGPPPL 982
Score = 88.2 bits (217), Expect = 3e-16
Identities = 150/874 (17%), Positives = 347/874 (39%), Gaps = 79/874 (9%)
Query: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529
+ +L + +R++ + + V K ++ + Q+ +++ + WL + +L + V +
Sbjct: 18 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 77
Query: 3530 G-DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQD--- 3585
++ + L + QELQ + + SVL+ E ++ A D +S++Q
Sbjct: 78 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 137
Query: 3586 ----WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE--------------- 3626
W+ E R + + + + ++WLK++E
Sbjct: 138 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 197
Query: 3627 KKWHEEVTAYRDEVEE-------VGARAQEILDESHVNSRMGCQATQLT----SRYQALL 3675
K+ ++ A++ +V E + + + + E+ +S C Q+ R+ L
Sbjct: 198 KEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS--ACSLKQMVHEGNQRWDNLQ 255
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
+V ++ L+ I EE E++ S W N I+ + K+K L
Sbjct: 256 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTN----IEHFSECDVQAKIKQL 311
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMT 3795
+ +++ H+ ++ +GE+ ++ E +A + +E+ + +E+ V + H
Sbjct: 312 KAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 371
Query: 3796 LEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHE 3855
L + E + L + LH + L + + SL Q + S
Sbjct: 372 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 431
Query: 3856 PSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAM-MEEIAGFEDR---LNN 3911
+ LE D L ++ S +A+ E+ G +D+ L
Sbjct: 432 SGRDTPASVDSIPLEWDHDYDLSRDLESAMS---------RALPSEDEEGQDDKDFYLRG 482
Query: 3912 LQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQ 3971
D +I + + KL +N ++ T +SA+ S +++ ++L+ + +
Sbjct: 483 AVGLSDVMIPESPE-AYVKLTENA---IKNTSGDHSALESQIRQLGKALDDSRFQIQQTE 538
Query: 3972 DTLQQCQAWLSAVQPDLEPSPQPPLSR-AEAIKQVKHFRALQEQARTYLDLLCSMCDLSN 4030
+ ++ + P+L+ S + + E + + L+ + + + L +L +
Sbjct: 539 NIIRS----KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS 594
Query: 4031 ASVKTTAKDIQQTE----QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+T A I + E Q + ++L QNL Q W++ + +W +L D +++L+ ++
Sbjct: 595 TETQT-AGVIDRWELLQAQALSKELRMKQNL-QKWQQFNSDLNSIWAWLGDTEEELEQLQ 652
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQA---SVNTIIEKVNKLTKKEESPEHKEINHL 4143
R ++ + + ++K+ K + ++A S+N + + KE ++ +
Sbjct: 653 RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 712
Query: 4144 NDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNL----ARSDAES 4199
N +W +C ++ L + + +H+ + + + LE + + + DAE
Sbjct: 713 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
Query: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4259
H + L ++ L E + + L+D +++ + D KE+ + R
Sbjct: 773 LQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRL----K 828
Query: 4260 LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
L+ +++ + LE+L V S Q+L W+ +
Sbjct: 829 LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 862
Score = 73.9 bits (180), Expect = 6e-12
Identities = 156/844 (18%), Positives = 338/844 (40%), Gaps = 70/844 (8%)
Query: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICS-SATETYKVLQEHMDLCQALESLSSAITAFS 1620
Q+ ++N+ ++ ++ E +LA PI S ++ E + L E +L + +E S+ + +
Sbjct: 50 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 109
Query: 1621 ASARKVVNR-DSCVQEAAA---------LQQQYEDILRRAKERQTALENLLAHWQRLEKE 1670
+++ D+C +A L +++ +I + ER+ +E WQ+ +
Sbjct: 110 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 169
Query: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
S F WL+ E A+ P V E EL+ +A Q +V + + + L
Sbjct: 170 YSRFEDWLKSSERTAAFPSSSGVIYTVAKE-ELKKFEAFQRQVHECLTQLELINKQYRRL 228
Query: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1790
D +K + + ++RW +L + + + L+ + + ++F+ S VW+
Sbjct: 229 ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTE 288
Query: 1791 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
+L S D Q + + K E+ +++ + +L D +++
Sbjct: 289 MDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 348
Query: 1851 GKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESD 1910
+ ++ + +E VER L L H + ++ + E
Sbjct: 349 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEH--------------DLSDRELELEDS 394
Query: 1911 LIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQ 1970
DL+ ++A +L S S + LS AQ + S A+ D + E +
Sbjct: 395 AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ---PLRSERSGRDTPASVDSIPLEWDHDY 451
Query: 1971 NLLGTKQSE-ADALAVLKKAFQDQKEELLK---SIEDIEERTDKERLKEPTRQALQQRLR 2026
+L +S + AL + QD K+ L+ + D+ E + T A++
Sbjct: 452 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 511
Query: 2027 VFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQG 2086
+ LE ++ L D QI Q + + L+ ++ +L+ G
Sbjct: 512 DHSALESQIRQLGKA---LDDSRFQIQQTENIIRSKTPTG-PELDTSYKGYMKLL----G 563
Query: 2087 QCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQ 2146
+C ID ++ ++ + L ++ T T D +W + + ++ KQ
Sbjct: 564 ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID-RWELLQAQALSKELRMKQ 622
Query: 2147 ---------KDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2197
DL++ + EL+++ + S +E + K L +K ++
Sbjct: 623 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKK-LKELQKAVDHRK 681
Query: 2198 RLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALR 2257
+ +S+++ + D E S + ++++ D R LL+E+ +++ ++
Sbjct: 682 AIILSINLCSPEFTQADSKE--SRDLQDRLSQMNGRWD---RVCSLLEEWRGLLQDALMQ 736
Query: 2258 LEELHSKVNDLKELTKNL-----ETPPDLQFIEADLMQKLEHAKEIT----EVAKGTLKD 2308
+ H + L + +N+ E P ++A+++Q +H K++ E+ + L+
Sbjct: 737 CQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ--DHHKQLMQIKHELLESQLRV 794
Query: 2309 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQE 2368
+ Q + +N T + +E ++ N LK+V KEL+ + ++SS+Q+
Sbjct: 795 ASLQDMSCQLLVNAEGTDCLEAKEK-VHVIGNRLKLLLKEVSRHIKELE-KLLDVSSSQQ 852
Query: 2369 NLNS 2372
+L+S
Sbjct: 853 DLSS 856
Score = 72.0 bits (175), Expect = 2e-11
Identities = 60/358 (16%), Positives = 149/358 (41%), Gaps = 17/358 (4%)
Query: 7557 GKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE 7616
G++L ++ + ++ +L ++ ++W+ + + KKL L ++ +K ++
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 7617 KLRTFKKKLSQSL-------PDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSA 7669
L + +L++ + + +L+ +Q +++E L +L A
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 7670 YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME 7729
+ + + + L R+W +C RR +I E W F + +WL E
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
Query: 7730 SKVS--QNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIE 7785
+ + ++ E+LKK +Q ++ + + RLA+ + A ++
Sbjct: 182 RTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 241
Query: 7786 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7845
+ + N RW +L + + +++LK + ++ + S+ WL ++ +L +
Sbjct: 242 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 301
Query: 7846 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLL---HDCDACATDAECDSIQQ 7900
C ++Q K+ + + Q++I + + ++ E L+ DA + E D +++
Sbjct: 302 C---DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
Score = 70.1 bits (170), Expect = 9e-11
Identities = 153/829 (18%), Positives = 321/829 (38%), Gaps = 94/829 (11%)
Query: 7125 QLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTV 7184
+L K H + L +VN RW +LL+ IA +++ K L Q+ K +S
Sbjct: 4 RLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQ---LDKNMSSLR 60
Query: 7185 QQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVD 7244
+EL K +E+ + + +L + + + + L E L D
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 7245 ASAASA----IQSDQLSLS---QHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWI 7297
A A A IQ +L +++CA+ +++ ++ ++ F E W+
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSM---ERRLKIEETWRLWQKFLDDYSRFEDWL 177
Query: 7298 VEAEEILQGQDPSHSSDLSTI-QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-- 7354
+E PS S + T+ +E +++ + + L+ +N+ RL ++
Sbjct: 178 KSSER--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 235
Query: 7355 ---EIKRM-QNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV 7410
+K+M N+ W + + T +L+ F+ Q + F ++ + +L + + +L
Sbjct: 236 SACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLT- 294
Query: 7411 EISGNYQHLLE---QQRAHEL--FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLK 7465
N +H E Q + +L FQ E+ + II G++L+E+ + D +
Sbjct: 295 ----NIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEE 350
Query: 7466 LTLLSNQWQGVIRRAQQ------RRGIIDSQIRQWQRYREMAEKL---------RKWLVE 7510
L L Q V R ++ R + D + R E+ + R
Sbjct: 351 LDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSL 410
Query: 7511 VSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAE 7569
+S P S L S+ PL+ R+ D + + L Y L+ + + + S E
Sbjct: 411 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 470
Query: 7570 AALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLE-KLRTFKKKLSQS 7628
+ ++ + + + E + L ++ K G +LE ++R K L S
Sbjct: 471 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 530
Query: 7629 LPDHHEELHAEQMRCKELENAVGSWTD-----DLTQLSLLKDTLSAYISADDISILNERV 7683
+ + ++ EN + S T D + +K S D + L ++
Sbjct: 531 -----------RFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL 579
Query: 7684 ELLQR--------------------QWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCE 7723
+ + +WE L Q + ++ + L +W F+ +
Sbjct: 580 KEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWA 639
Query: 7724 WLTQMESKVSQ------NGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASH 7777
WL E ++ Q + DI E+ K K+ Q+ + + + + +A
Sbjct: 640 WLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD- 698
Query: 7778 ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL 7837
++ +++ +L ++N RW + L+ L++ L+ Q + L L +I+
Sbjct: 699 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRK 758
Query: 7838 AKPIVYDS-CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNL-CEVLLH 7884
+ + DS ++E +Q + +++ ++ + VAS+ ++ C++L++
Sbjct: 759 NEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 807
Score = 67.0 bits (162), Expect = 8e-10
Identities = 148/839 (17%), Positives = 321/839 (38%), Gaps = 117/839 (13%)
Query: 2973 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECW--HKGQEILDALQKAEPRTEDLKSQL 3030
+ L+ +A +K + L ++ + + + W H E+ + +E+++ +L
Sbjct: 29 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKL 88
Query: 3031 NELCRFSRDLSTYSGKVSGLIKE-----YNCLCLQASKGCQNKEQI-------------- 3071
NE RD+ +S V+ ++ ++C C + +Q
Sbjct: 89 NEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 148
Query: 3072 -------------LQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFL 3118
L Q+F + F+ WL +++ T A + L+K + F
Sbjct: 149 SMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQ 208
Query: 3119 SESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENL 3178
+ +L ++ + L+ + A ++ V + W N + L++
Sbjct: 209 RQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHF 268
Query: 3179 KIQMKDFEVSAEPIQDWLSKTE-KMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQL 3237
Q ++FE + + I WL++ + ++ + D+ AK ++ + Q +EI ++
Sbjct: 269 IGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ---QEISLNHNKI 325
Query: 3238 NRLKEKAQQLWEGQAASKS--FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLG 3295
++ + +QL E + + +L + + +L R+ ++ L
Sbjct: 326 EQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLS 385
Query: 3296 IKELQDWMTDAIHMLDSYCHPTSDKSVLDSR-TLKLEALLSVKQEKEIQMKMIVTRGESV 3354
+EL+ + D+ + D + H S S+L + + L L+ E + +S+
Sbjct: 386 DRELE--LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSI 443
Query: 3355 -------------LQNTSPEGIPTIQQQLQSVKDMW----ASLLSAGIR---------CK 3388
L++ +P+ ++ Q KD + L I +
Sbjct: 444 PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
Query: 3389 SQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT--------TMLGKAK 3440
+ ++ ++ + +RQ +D + ++E +R KT + G K
Sbjct: 504 NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRSKTPTGPELDTSYKGYMK 560
Query: 3441 LLNEEVLSYSSL------LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3494
LL E S S+ L+ E G + T+ + + +R+ +Q +A +
Sbjct: 561 LLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRM 620
Query: 3495 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE--GDAHTHETTLRDLQELQVHCAEG 3552
++ ++ Q++ DL + WLG +E+L+Q LE D T E ++ L+ELQ
Sbjct: 621 KQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHR 680
Query: 3553 QALLNSVLHTREDVIPSGIPQA---EDRALE---------SLRQDWQAYQHRLSETRTQF 3600
+A++ S+ + + ++ +DR + SL ++W+ F
Sbjct: 681 KAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGF 740
Query: 3601 NNVVNKLRLMEQKFQQ-------VDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDE 3653
+ + + L LM + + +D L + H+++ + E+ E R + D
Sbjct: 741 HEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 800
Query: 3654 S---HVNSR-MGCQATQ-----LTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYS 3703
S VN+ C + + +R + LL +V IK L E++ + S+ LSS+S
Sbjct: 801 SCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL-EKLLDVSSSQQDLSSWS 858
Score = 65.5 bits (158), Expect = 2e-09
Identities = 129/808 (15%), Positives = 321/808 (39%), Gaps = 88/808 (10%)
Query: 2280 DLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLM---- 2335
++++ + + +H ++ LK+ Q++K ++ + TW +E L
Sbjct: 16 EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
Query: 2336 --NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESLGRAM 2389
+C E L + +++Q++++ + ++S L + AE +S+ +A
Sbjct: 76 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
Query: 2390 TGLIKKHEAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSK 2447
L ++ + + + + ++E+ L + F + F++W ++ A S
Sbjct: 136 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
Query: 2448 VLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFL 2507
V + +L + V + ++L+ + ++ + L S+++ + + N+ +
Sbjct: 196 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQ 255
Query: 2508 KQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME-ERFNTENLGESKQHIPEKKNEVHK 2566
K+ + L+ + FE + +W+ EM+ + N E+ E + + ++ +
Sbjct: 256 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC-----DVQAKIKQ 310
Query: 2567 VEMFLGELLAARESLDKLSQRGQLLSEEG---------HGAGQEGRLCSQLL----TSHQ 2613
++ F E+ ++++ +G+ L E+ + R C ++ H+
Sbjct: 311 LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
Query: 2614 NLLRM----TKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
L+R+ + L ++ L++ AL + W D L + + +L +
Sbjct: 371 KLIRLPLPDDEHDLSDRELELEDSAALSDL-----HWHDRSADSLLSPQPSSNLSLSLAQ 425
Query: 2670 RLSQIQ---------DILLMKGEGEVKLNMAIGKG-EQALRSSNKEGQRVIQTQLETLKE 2719
L + D + ++ + + L+ + +AL S ++EGQ L
Sbjct: 426 PLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVG 485
Query: 2720 VWADIM---SSSVHAQSTLESVISQWNDYVERKNQLEQWMESVD------QKIEHPLQPQ 2770
+ +D+M S + + T ++ + D+ ++Q+ Q +++D Q+ E+ ++ +
Sbjct: 486 L-SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSK 544
Query: 2771 -PGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKT--- 2826
P E +L E ++ RL K +E E+ F + E +T
Sbjct: 545 TPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKE--EEESLPGFVNLHSTETQTAGV 602
Query: 2827 --QFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS--DMSGDSSA 2882
++ + A K ++++ ++ + ++ WL +EEL + ++S D
Sbjct: 603 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQT 662
Query: 2883 TQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWED 2942
+ ++ K+KEL + + + + + +PE Q + +L + + W +
Sbjct: 663 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDL-QDRLSQMNGRWDRVCS 721
Query: 2943 SVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEI 3002
+ + + L++ + Q + G + LE + + ++ N D EI
Sbjct: 722 LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPI---------DSNLDAEI 772
Query: 3003 VECWHKGQEILDALQKAEPRTEDLKSQL 3030
++ HK Q + + E L+SQL
Sbjct: 773 LQDHHK--------QLMQIKHELLESQL 792
Score = 62.0 bits (149), Expect = 2e-08
Identities = 152/818 (18%), Positives = 313/818 (38%), Gaps = 116/818 (14%)
Query: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751
S++E +L ++ + W + ++ + +L+ L + + L WL + L
Sbjct: 15 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL---A 71
Query: 6752 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATL 6806
+ V E ++ LN E ++++ S+ +SVL+ LL + ++
Sbjct: 72 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 131
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
+ +D +W ++ + K+ + S W+ E +
Sbjct: 132 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS- 190
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+ Y E L+K++ F+ ++ ++ +N+ +++ R ++TD A L
Sbjct: 191 --GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLA-------RENRTDSACSLK 241
Query: 6927 AM----NKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGD 6982
M N+ W LQ VT ++ L+ + E+E + W + +L
Sbjct: 242 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF-S 300
Query: 6983 QASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWAN 7042
+ VQ +K + + I ++E+I G LI+ + ++I+ L EL +
Sbjct: 301 ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQE 360
Query: 7043 L-------------------DHMVGQLKILLK--SVLDQWSSHKVAFDKINSYLMEARYS 7081
+ +H + ++ L+ + L H + D + S + S
Sbjct: 361 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 420
Query: 7082 LSRFRLL---------TGSLEAVQVQVDNLQNLQDDLEK----------------QERSL 7116
LS + L S++++ ++ D+ +L DLE ++ L
Sbjct: 421 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 480
Query: 7117 QKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDY 7176
+ +++ ++ E + N +K + + L +I Q KAL D
Sbjct: 481 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIR---QLGKAL--------DD 529
Query: 7177 SKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELG 7236
S+ +QQ E+ K T ++ D +++ + + +VK L E
Sbjct: 530 SR---FQIQQTENIIRS--KTPTGPEL-DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
Query: 7237 EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAW 7296
E L V+ + + + + L A QAL K + ++ + ++ F L ++ AW
Sbjct: 584 ESLPGFVNLHSTETQTAGVIDRWELLQA--QALSK-ELRMKQNLQKWQQFNSDLNSIWAW 640
Query: 7297 IVEAEEIL-QGQDPSHSSDLSTIQERMEEL----------KGQMLKFSSMAPDLDRLNEL 7345
+ + EE L Q Q S+D+ TI+ ++++L K +L + +P+ + +
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 7346 GYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTF----------LEKCE 7395
R L D R+ +N W + S E LQ L+Q Q F LE +
Sbjct: 701 ESR-DLQD----RLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 755
Query: 7396 TWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEM 7433
+V + L EI ++ L Q + HEL ++++
Sbjct: 756 RRKNEIVPIDSNLDAEILQDHHKQLMQIK-HELLESQL 792
Score = 59.7 bits (143), Expect = 1e-07
Identities = 127/696 (18%), Positives = 276/696 (39%), Gaps = 67/696 (9%)
Query: 7447 GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRK 7506
G+RL + E KL ++++WQ ++ R + + Q+ + LR
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 7507 WLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADS 7566
WL + + ++ + +E Q ++ + + + LL D+
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 7567 GAEAA----LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFK 7622
A A +Q + +W++ E++ K+ + W+K + + L++ +
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSE 181
Query: 7623 KKLSQSLPDHHEELHA-EQMRCKELENAVGSWTDDLTQLSLLKDT---LSAYISADDISI 7678
+ + + P ++ + K+ E + LTQL L+ L+ D
Sbjct: 182 R--TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS 239
Query: 7679 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQN 7735
L + V ++W+ L +++ +++ + + F + WLT+M+ + +
Sbjct: 240 LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF 299
Query: 7736 GDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
+ ++ I++LK +Q+EI++ Q+ GE+L + S A+ IE +L ++
Sbjct: 300 SECDVQAKIKQLKA-FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 358
Query: 7796 QHLLDLIAARVKKL------------------KETLVAVQQL---DKNMSSLRT--WLAH 7832
Q + + KKL E A+ L D++ SL + ++
Sbjct: 359 QEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSN 418
Query: 7833 IESELAKPIVYD------SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDC 7886
+ LA+P+ + + + I + + +L RD+E S ++ + E D
Sbjct: 419 LSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE--SAMSRALPSEDEEGQDDK 476
Query: 7887 DACATDAECDS---IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDW 7943
D A S I ++ + N + +E R K LDD SRF+
Sbjct: 477 DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDD-SRFQ-- 533
Query: 7944 LKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRT-- 8001
++ +E + +G E ++ + + + EC + ++ + + +L E +
Sbjct: 534 IQQTENIIRSKTPTG------PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLP 587
Query: 8002 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 8059
+ S + RW+ LQ + S R+K + + ++F + +SI WL + + +
Sbjct: 588 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 647
Query: 8060 LTNIEHFS-ECDVQA---KIKQLKAFQQEISLNHNK 8091
L ++ D+Q +IK+LK Q+ +++H K
Sbjct: 648 LEQLQRLELSTDIQTIELQIKKLKELQK--AVDHRK 681
Score = 58.5 bits (140), Expect = 3e-07
Identities = 163/931 (17%), Positives = 353/931 (37%), Gaps = 144/931 (15%)
Query: 4999 DLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
++E K+ + R Q + A+V L+ K + + E +L++ +
Sbjct: 16 EIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIV 75
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL----EEKASQLEKTGNDASKATLSRSM 5114
+ +S E + KL+E + L + + ++ E + DA ++ ++
Sbjct: 76 YDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQAT 135
Query: 5115 TTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKA 5174
+ +RW + A++ ++ +E+ W F + + + + + S+
Sbjct: 136 RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT 195
Query: 5175 ELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCL 5234
L+ + F ++ + + L ++ +Q + ++ + L Q + R
Sbjct: 196 VAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS---LKQMVHEGNQRWD 252
Query: 5235 NMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN----PTIEIDAQLEELQ 5290
N+Q++V + + +K + RE ET +S+ W+ E L N ++ A++++L+
Sbjct: 253 NLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK 312
Query: 5291 ILLTEATNHRQNIEKM------------------------------------AEEQKEKY 5314
E + + IE++ E +K
Sbjct: 313 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL 372
Query: 5315 LGL------YTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQK--- 5365
+ L + + EL L+ + DL D+ D + + S S L++ ++
Sbjct: 373 IRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERS 432
Query: 5366 --------------------LAKDLTTILTKLKAKTDNVVQAKTD---------QKVLGE 5396
L++DL + +++ D Q D V+
Sbjct: 433 GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIP 492
Query: 5397 ELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAAS 5456
E KL E A++ + L + +++GK + + I+Q EN +
Sbjct: 493 ESPEAYVKLTE--NAIKNTSGDHSALESQI-RQLGKALDDSRFQIQQTENIIRSKTPTGP 549
Query: 5457 HLEE----YNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS-- 5510
L+ Y ++L I+ K L H L LH T + + ID
Sbjct: 550 ELDTSYKGYMKLLGECSSSIDSVKRLEHK--LKEEEESLPGFVNLHSTETQTAGVIDRWE 607
Query: 5511 --ELEAMTEKLQYLTSVYCTEKMSQQV----AELGRETEELRQMIKIRLQ-NLQDAAKDM 5563
+ +A++++L+ ++ ++ + + A LG EEL Q+ ++ L ++Q +
Sbjct: 608 LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
Query: 5564 KKFEAELKKLQAALEQAQA-----TLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAV 5618
KK LK+LQ A++ +A L SPE + KE Q LS+M +V
Sbjct: 668 KK----LKELQKAVDHRKAIILSINLCSPEFTQADSKES-RDLQDRLSQMNGRWDRV--C 720
Query: 5619 QLCQSALRIPEDVVASL----PLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQ 5674
L + + +D + + H L + E R ++ + + + A ++Q
Sbjct: 721 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQ------ 774
Query: 5675 EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKML 5734
H +QL++ H E+ + + +++Q++ Q+ + E ++ +E++ + ++ K+L
Sbjct: 775 --DHHKQLMQIKH-ELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKLL 830
Query: 5735 TMK-AKHATMLLTVTEVEGLAEGTE--------DLDGELLPTPS-AHPSVVMMTAGRCH- 5783
+ ++H L + +V + D G + PT + P+ G+C
Sbjct: 831 LKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSL 890
Query: 5784 ----TLLSPVTEESGEEGTNSEISSPPACRS 5810
+S S + G++S +S P RS
Sbjct: 891 SQPGPSVSSPHSRSTKGGSDSSLSEPGPGRS 921
Score = 58.2 bits (139), Expect = 4e-07
Identities = 181/887 (20%), Positives = 351/887 (39%), Gaps = 150/887 (16%)
Query: 1198 LTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELIS 1257
L + S E++A + +L K++ ++ L+ L++ K L VQ + +SL ++
Sbjct: 5 LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 64
Query: 1258 GSKEVQEQAEK--ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQ----QGEG 1311
++ + K + D+ N E Q+ L Q+ + I V + + +
Sbjct: 65 ---HIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 1312 GLPDRGHEELRKLESTLDGLERS--RERQERRIQV--TLRKWERFETNKETVVRYLFQTG 1367
D + +++ LD R+ ERR+++ T R W++F + +L
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL---- 177
Query: 1368 SSHERFLSFSSLESL-----SSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL 1422
S ER +F S + EL++ + F ++ Q E + K+ L +N+
Sbjct: 178 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRR--LARENRT- 234
Query: 1423 LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHF---GSNFET----LSVWITEKEKE 1475
A S+K+ V + + K + + + HF FET + VW+TE + +
Sbjct: 235 --DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQ 292
Query: 1476 LNALETSSSA-MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1534
L +E S + +I Q+K QEI + I + + + + ++A I+ +L
Sbjct: 293 LTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELD 352
Query: 1535 QIRRYGEEL-----REHAQCL-------------------EGTILGHLSQQQKFEENLRK 1570
++RRY +E+ R H + + + L L + ++L
Sbjct: 353 ELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLS 412
Query: 1571 IQQSVSEFEDKLAVPIKICSSATETYKVL-------QEHMDLCQALES-LSSAITAFSAS 1622
Q S S LA P++ S +T + DL + LES +S A+ +
Sbjct: 413 PQPS-SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
Query: 1623 ARKVVNRDSCVQEAAALQ------------QQYEDILRRAKERQTALENLLAHWQRLEKE 1670
+ ++D ++ A L + E+ ++ +ALE+ + ++L K
Sbjct: 472 GQD--DKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI---RQLGKA 526
Query: 1671 LSSFLTWLERGE-----AKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQ 1725
L +++ E + PE+D S +G ++L+ + + S KL +
Sbjct: 527 LDDSRFQIQQTENIIRSKTPTGPELDTS-----YKGYMKLLGECSSSIDSVKRLEHKLKE 581
Query: 1726 LKESLFSVASKDDVKMMKLHLEQLDERWRDL-PQIINKRINFLQSVVAEHQQFDELLLSF 1784
+ESL ++ + + +RW L Q ++K + Q+ + + QQF+ L S
Sbjct: 582 EEESLPGFV---NLHSTETQTAGVIDRWELLQAQALSKELRMKQN-LQKWQQFNSDLNSI 637
Query: 1785 SVWI------KLFLSELQTTSEISIMDHQV----ALTRHKDHAAEV------------ES 1822
W+ L L+ +++I ++ Q+ L + DH + ++
Sbjct: 638 WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 697
Query: 1823 KKGELQSLQGHLAKL-GSLGRAEDL-----HLLQGKAEDCFQLFEEAS-------QVVER 1869
E + LQ L+++ G R L LLQ C Q F E S + ++R
Sbjct: 698 DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQC-QGFHEMSHGLLLMLENIDR 756
Query: 1870 RQLALSHL-----AEFLQS-HASLSGILRQLRQTVEATNSMNKNESD-LIEKDLNDALQN 1922
R+ + + AE LQ H L I +L ++ S+ L+ + D L+
Sbjct: 757 RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA 816
Query: 1923 AKALESAAVSLDGILSKAQYHLK-------IGSSEQRTSCRATADQL 1962
+ + L +L + H+K + SS+Q S ++AD+L
Sbjct: 817 KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 863
Score = 58.2 bits (139), Expect = 4e-07
Identities = 139/794 (17%), Positives = 312/794 (39%), Gaps = 85/794 (10%)
Query: 6488 ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVS 6547
+L K+ D + L+ +I +R L + L Q ++ + L L + ++A
Sbjct: 20 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSC 79
Query: 6548 SKEEIQQLLDKHKEYFQGLESH-------MILTETLFRKIISFAVQKE----TQFHTELM 6596
+ EEIQ+ L++ +E + +E H + L E L + A E Q L
Sbjct: 80 NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLD 139
Query: 6597 AQASAVLKRAHKRGVELEYILETW-SHLD-----EDQQELSRQLEVVESSIPSVGLVEEN 6650
+ + + +R +++E W LD ED + S + SS + V +
Sbjct: 140 RRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKE 199
Query: 6651 EDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTN 6710
E + + H + E K Y+ L R + S L+ +++ + W +
Sbjct: 200 ELKKFEAFQRQVHECLTQLELINKQYRRLARENR---TDSACSLKQMVHEGNQRWDNLQK 256
Query: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6770
+++ L RL+ + +++ ++ WL +L ++ E + V+ +
Sbjct: 257 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-----TNIEHFSECD-VQAKIKQ 310
Query: 6771 FLEFSKEVDAQSSLKSSVLSTGNQLL-RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQE 6829
F +E+ + +++ G QL+ + + +D A + EL + ++ + +
Sbjct: 311 LKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHK 370
Query: 6830 KLHQLQMD-----------KLPSRHAISEVMSWISLMENVIQ-KDEDNIKNSIGYKAIHE 6877
KL +L + +L A+S++ ++++ + N+ S+ E
Sbjct: 371 KLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 430
Query: 6878 YLQKYKGFKIDI------NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 6931
+ +D + L+ D + + S+D E + D DF + GA+ S
Sbjct: 431 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQ--DDKDFYLR-GAVGLS 487
Query: 6932 WQILQGLVTEKIQLLEGLLES----WSEYENNVQCLKTWFETQEKRLKQQHRI------- 6980
++ ++L E +++ S E+ ++ L + +++Q I
Sbjct: 488 DVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPT 547
Query: 6981 -----GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN--GLALIQNKKEDVSSIVMSTL 7033
L +C D +K E ++++ E++ G + + + + ++
Sbjct: 548 GPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI---- 603
Query: 7034 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL--LTGS 7091
W L ++ +K L +W + I ++L + L + + L+
Sbjct: 604 ----DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD 659
Query: 7092 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWN- 7150
++ +++Q+ L+ LQ ++ ++ + ++ + + + L + L ++N RW+
Sbjct: 660 IQTIELQIKKLKELQKAVDHRKAIILSI-NLCSPEFTQADSKESRDLQDRLSQMNGRWDR 718
Query: 7151 --NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD--IADD 7206
+LLEE LQ AL+Q Q + + S ++ + R NE++ +N D I D
Sbjct: 719 VCSLLEEWRGLLQD--ALMQC-QGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
Query: 7207 EVATWIQDCNDLLK 7220
+Q ++LL+
Sbjct: 776 HHKQLMQIKHELLE 789
Score = 52.4 bits (124), Expect = 2e-05
Identities = 53/268 (19%), Positives = 111/268 (41%), Gaps = 26/268 (9%)
Query: 6913 SKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 6972
S S ++ +LG +N WQ L L+ +++ L+ L + + + N+ L+TW E
Sbjct: 9 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 68
Query: 6973 RLKQQ--HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKE------- 7023
L + + + +Q L + Q+L ++++EK G+A + N E
Sbjct: 69 ELAKPIVYDSCNSEEIQRKLNEQQEL-------QRDIEK-HSTGVASVLNLCEVLLHDCD 120
Query: 7024 ------DVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7077
+ SI +T R L + W N+ M + ++ ++ W + + +L
Sbjct: 121 ACATDAECDSIQQAT-RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS 179
Query: 7078 ARYSLSRFRLLTGSLEAV-QVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 7136
+ + + F +G + V + ++ + Q + + L+ +L +E
Sbjct: 180 SERT-AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSAC 238
Query: 7137 TLTNTLKEVNMRWNNLLEEIAEQLQSSK 7164
+L + E N RW+NL + + L+ K
Sbjct: 239 SLKQMVHEGNQRWDNLQKRVTSILRRLK 266
Score = 52.4 bits (124), Expect = 2e-05
Identities = 148/822 (18%), Positives = 313/822 (38%), Gaps = 82/822 (9%)
Query: 4243 VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK- 4301
++ + + RW L DLI +++ L + + L W + +A+ +
Sbjct: 17 IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVY 76
Query: 4302 QSPPPDMAQNLLMDHLAICSELEAKQM-------LLKSLIKDADRVMADLGLNERQVIQK 4354
S + Q L + + ++E L + L+ D D D E IQ+
Sbjct: 77 DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA---ECDSIQQ 133
Query: 4355 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
A + + + +RR + + +FL + ++ ER F ++
Sbjct: 134 ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVI 193
Query: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
+++K ++ Q + ++ + Q R L +E + + E +D+
Sbjct: 194 YTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN 253
Query: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKY 4534
+ ++ + L+ L+ + R+ F+ D WL + D+ ++ + SE Q AK
Sbjct: 254 LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDL----QLTNIEHFSECDVQ-AKI 308
Query: 4535 QNILEQSPEY---ENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK-- 4589
+ + E N + + G+ ++ +D + + E+L+ L R + +
Sbjct: 309 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERY 368
Query: 4590 ----------DKFYKVQEAILARKEYASLIEL--------------TTQSLSELEAQFLR 4625
D + + + L ++ A+L +L + +LS AQ LR
Sbjct: 369 HKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLR 428
Query: 4626 MSKVPTDL-AVEEALSLQ-----DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPD 4679
+ D A +++ L+ D R + ++ + DE Q + F G D
Sbjct: 429 SERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSD 488
Query: 4680 KML-HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK----SVKEEQSKVN 4734
M+ Y +L + +++T+ + E +QL + L +++ ++ +
Sbjct: 489 VMIPESPEAYVKLTE------NAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR 542
Query: 4735 EETLPAEE---KLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQ 4791
+T E K Y L G S +KR+ L++ L H ++
Sbjct: 543 SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV---NLHSTETQT 599
Query: 4792 GELKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDL--N 4845
+ + E RM Q++ F ++++ WL + EL L+L +
Sbjct: 600 AGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTD 659
Query: 4846 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4905
+Q I+ +I+K++ Q+ V I+ +++ E FT+A S DL+ L++++
Sbjct: 660 IQTIELQIKKLKELQKAVDHRKAIILSINLCSPE-FTQADSKESRDLQDRLSQMNGRWDR 718
Query: 4906 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED----AQELLQLAGNGLDVESAEENL 4961
+ L + L + QCQ ++++ LE+ E++ + N LD E +++
Sbjct: 719 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSN-LDAEILQDHH 777
Query: 4962 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQK 5003
K M+ + + L + L L+ G + LE K
Sbjct: 778 KQLMQIKHELLESQLRVASLQDMSCQL--LVNAEGTDCLEAK 817
Score = 52.4 bits (124), Expect = 2e-05
Identities = 64/353 (18%), Positives = 156/353 (44%), Gaps = 21/353 (5%)
Query: 6623 LDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDG 6682
LD+ + ++ + ++ S P+ E + + L SS++ + +++ ++
Sbjct: 527 LDDSRFQIQQTENIIRSKTPTG---PELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEE 583
Query: 6683 KRLLISISCSDLESQLNQLGECW-LSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6741
+ L ++ E+Q + + W L +SKEL R++ L+ W ++ S+ + WL
Sbjct: 584 ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKEL-RMKQNLQKWQQFNSDLNSIWAWLG 642
Query: 6742 SAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV 6801
++ LE Q + + +++ + + E K VD + ++ S+ + +
Sbjct: 643 DTEEELE--QLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 6802 DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLM-ENVIQ 6860
++ L+ LS+++ +W + ++ E+ L D L E+ + LM EN+ +
Sbjct: 701 ESRDLQDRLSQMNGRW----DRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR 756
Query: 6861 KDED--NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDK 6918
+ + I +++ + + ++ ++ K ++ QL V + Q+ V ++ +D
Sbjct: 757 RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLL---VNAEGTDC 813
Query: 6919 TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 6971
+ E++ + ++L V+ I+ LE LL + ++ Q L +W E
Sbjct: 814 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL----DVSSSQQDLSSWSSADE 862
Score = 52.0 bits (123), Expect = 3e-05
Identities = 177/930 (19%), Positives = 351/930 (37%), Gaps = 131/930 (14%)
Query: 5865 KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRS 5924
KLG + W+ L ++I+ + + L E L Q+ ++ S+ T + IE SE +P
Sbjct: 20 KLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIE---SELAKPIVY 76
Query: 5925 PESQMAEHQALMDEILMLQDEINELQSSLAE-----ELVSESCE--ADPAEQLALQSTLT 5977
E Q ++E LQ +I + + +A E++ C+ A AE ++Q
Sbjct: 77 DSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATR 136
Query: 5978 VLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDT 6037
L R I + +R +EE + Q++ + + WL S++ T
Sbjct: 137 NLDRRWRNICAMSMERRLKIEETW----------RLWQKFLDDYSRFEDWLKSSER---T 183
Query: 6038 ALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGK 6097
A P + + + Q L++L + N+ + + D A L
Sbjct: 184 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
Query: 6098 LRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ--- 6154
+ LQ+ + ++ ++EE + T + WL + T
Sbjct: 244 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFE-----TARDSILVWLTEMDLQLTNIEH 298
Query: 6155 ----QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE 6210
Q+ ++Q K +QE++ + + + ++GE+++ + + + ++ +E
Sbjct: 299 FSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--------IIEEE 350
Query: 6211 LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKG 6270
L D++R + + K L + + E L R L L
Sbjct: 351 L----------DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL--S 398
Query: 6271 DVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATST----WLDDV 6326
D+ D+SA SLL + SS + Q + E+ D ++ + W D
Sbjct: 399 DLHWHDRSA-DSLLS------PQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDY 451
Query: 6327 EERLFVATAL---LPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR-DV 6382
+ + +A+ LP E E +++ + +S+ M PE+ + +
Sbjct: 452 DLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM----------IPESPEAYVKL 501
Query: 6383 IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDL--KVLFTSLADNKYIILQKL 6440
E+ + G S L+S + Q + + QI +N + K D Y KL
Sbjct: 502 TENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFD---AGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6497
+ I+++++ E LKE + G + L + + + + D ++
Sbjct: 562 LG----ECSSSIDSVKRLEHKLKEEEESLPGFVNL----------HSTETQTAGVIDRWE 607
Query: 6498 ELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLD 6557
L S+ + QNL Q+ L + L +E++ Q++ +S+ + +L
Sbjct: 608 LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQI 667
Query: 6558 KHKEYFQGLESH---MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELE 6614
K + Q H +IL+ L + A KE++ + ++Q + R
Sbjct: 668 KKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCS------ 721
Query: 6615 YILETWSHLDEDQ-------QELSR----QLEVVESSIPSVGLVEENEDR--LIDRITLY 6661
+LE W L +D E+S LE ++ + ++ N D L D
Sbjct: 722 -LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 780
Query: 6662 QHLKSSLNEYQPKLYQVLDDGKRLLIS---ISCSDLESQLNQLGECWLSNTNKMSKELHR 6718
+K L E Q ++ + D +LL++ C + + +++ +G ++S+ +
Sbjct: 781 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 840
Query: 6719 LETILKHWTRYQSESADLIHWLQSAKDRLE 6748
LE +L S DL W S+ D L+
Sbjct: 841 LEKLLD----VSSSQQDLSSW--SSADELD 864
Score = 51.2 bits (121), Expect = 4e-05
Identities = 161/928 (17%), Positives = 345/928 (37%), Gaps = 101/928 (10%)
Query: 3135 GELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQD 3194
GE L+ + KA I+ K+ + W++ + + L+ + ++ + + ++
Sbjct: 2 GERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 3195 WLSKTEK-----MVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE 3249
WL+ E +V++S N ++ K EQQ+LQ +E+ + L E +
Sbjct: 62 WLAHIESELAKPIVYDSCNS-EEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 3250 G---QAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDA 3306
A S + L ++ + ++ E+ +++ +F +DW+ +
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS 180
Query: 3307 IHMLDSYCHPTSD---KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
+ P+S +V K EA E Q+++I + + + +
Sbjct: 181 ER---TAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
+++Q + W +L +L+ + + ++ W+ M+ L E
Sbjct: 238 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM---TEHYVTQLELQDLQERY 3480
H D + + K +E+ + +E I +G + +E + ++L E
Sbjct: 298 --HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
Query: 3481 RAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLR 3540
R QE +KL+RL L E L + +L+ + L D H H+ +
Sbjct: 356 RYCQEVFGRVERYHKKLIRL------PLPDDEHDLSDRELELEDSAAL-SDLHWHDRSAD 408
Query: 3541 DLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF 3600
L Q +L + R + +++S+ +W H +R
Sbjct: 409 SLLSPQPSSNLSLSLAQPLRSERSG-------RDTPASVDSIPLEW---DHDYDLSRDLE 458
Query: 3601 NNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSR 3659
+ + L +++ Q D +L+ A D + A L E+ + +
Sbjct: 459 SAMSRALPSEDEEGQDDKDFYLRGA---------VGLSDVMIPESPEAYVKLTENAIKNT 509
Query: 3660 MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATK 3719
G + AL Q+ + K L++ ++++E+ + S + ++K
Sbjct: 510 SG--------DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKL 561
Query: 3720 IDKVDTVMMGKKLKTLEVLLKDMEK---GHSLLKSAREKGERAVKYLEEGEAERLRKEIH 3776
+ + + + +K LE LK+ E+ G L S + + E +A+ L KE+
Sbjct: 562 LGECSSSI--DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
Query: 3777 DHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE--EPKMEL 3834
+++ L ++F+ ++ W+ + +E L + E ++
Sbjct: 620 -------------------MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 660
Query: 3835 YEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL--VQDVTLKDKIDQLQSDYQDLC 3892
+ Q+ K K LQ+ V + + S+ + + L+D++ Q+ + +C
Sbjct: 661 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 720
Query: 3893 SIGKAMMEEIAG-FEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICS 3951
S ++EE G +D L Q + G ++N + D + I
Sbjct: 721 S----LLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLD--AEILQ 774
Query: 3952 TAQRMYQSLEHELQKHVSRQDTLQ--QCQAWLSAVQPDLEPSPQPPLSRAEAIKQV---- 4005
+ ++HEL + R +LQ CQ ++A D + + +K +
Sbjct: 775 DHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEV 834
Query: 4006 -KHFRALQEQARTYLDLLCSMCDLSNAS 4032
+H + L++ LD+ S DLS+ S
Sbjct: 835 SRHIKELEK----LLDVSSSQQDLSSWS 858
Score = 50.4 bits (119), Expect = 8e-05
Identities = 141/728 (19%), Positives = 273/728 (37%), Gaps = 177/728 (24%)
Query: 4788 QSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQ 4847
Q W K +TS + + + Q +F+T L WL + +L+ + +
Sbjct: 249 QRWDNLQKRVTSIL----RRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHF--SEC 302
Query: 4848 DIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQ 4907
D+Q +I++++ Q+E+ + + + + ++ K++ L +A +E L EL
Sbjct: 303 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRY----- 357
Query: 4908 EALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEF 4967
E++ + +RY++ L L + D+ E L+
Sbjct: 358 ---------CQEVFGRVERYHKKLIR-----------LPLPDDEHDLSDRELELEDS--- 394
Query: 4968 FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027
+ L +LH + D L+ P +L +A LRS+R RD+ A VD +
Sbjct: 395 --------AALSDLHWHDRSADSLLSPQPSSNLSLSLAQ-PLRSERSGRDTPASVDSI-- 443
Query: 5028 CTAQW-HDYQKARE-----------EVIELMNDTEKKLS---EFSLLKTSSSHEAEEKLS 5072
+W HDY +R+ E E +D + L S + S EA KL+
Sbjct: 444 -PLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 502
Query: 5073 E---------HKALVSVVNSFHEKIVALEEKASQLEKTGN-DASKATLSRSMTTVWQRWT 5122
E H AL S + + AL++ Q+++T N SK + T ++ +
Sbjct: 503 ENAIKNTSGDHSALESQIRQLGK---ALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYM 559
Query: 5123 RLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEY 5182
+L + E + + VK+ + + ++ LPG +
Sbjct: 560 KL--------------LGECSSSIDSVKRLEHKLKEEEESLPG-------------FVNL 592
Query: 5183 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT 5242
H T QT ++ DR +Q + +
Sbjct: 593 HST---------------ETQTAGVI----------------------DRWELLQAQALS 615
Query: 5243 NGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQN 5302
+KQ L+ + + +NS+ W+ +T+E +LE+LQ L E + Q
Sbjct: 616 KELRMKQNLQKWQQFNSDLNSIWAWLGDTEE-----------ELEQLQRL--ELSTDIQT 662
Query: 5303 IEKMAEEQKEKYLGLYTILPSELSLQLAE---VALDLKIRDQIQDKIKE----------- 5348
IE ++ KE + LS+ L D K +QD++ +
Sbjct: 663 IELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSL 722
Query: 5349 VEQSKATSQELSRQIQ---KLAKDLTTILTKLKAKTDNVV--QAKTDQKVLGE---ELDG 5400
+E+ + Q+ Q Q +++ L +L + + + +V + D ++L + +L
Sbjct: 723 LEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
Query: 5401 CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLS-KLNQAASHLE 5459
+L+E V + + QL L G ++ + NRL L + + H++
Sbjct: 783 IKHELLESQLRVASLQDMSCQL---LVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 839
Query: 5460 EYNEMLEL 5467
E ++L++
Sbjct: 840 ELEKLLDV 847
Score = 47.8 bits (112), Expect = 5e-04
Identities = 152/743 (20%), Positives = 287/743 (38%), Gaps = 100/743 (13%)
Query: 1728 ESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1787
E L + + ++ L ++++RW+ L +I R+ L+ + QQ D+ + S W
Sbjct: 3 ERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTW 62
Query: 1788 IKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLH 1847
+ SEL + ++ E++ K E Q LQ + K S G A L+
Sbjct: 63 LAHIESELAK-----------PIVYDSCNSEEIQRKLNEQQELQRDIEK-HSTGVASVLN 110
Query: 1848 LLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKN 1907
L + DC +A + Q A +L ++ ++S + R +E T + +
Sbjct: 111 LCEVLLHDCDACATDAE--CDSIQQATRNLDRRWRNICAMS---MERRLKIEETWRLWQK 165
Query: 1908 ESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT--SCRATADQLCGE 1965
D + D L++++ + S I + A+ LK + QR C + + +
Sbjct: 166 FLDDYSR-FEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 224
Query: 1966 VERIQNLLGTKQSEADALAVLKKAFQD---QKEELLKSIEDIEERTDK-ERLKEPTRQAL 2021
R+ +++ D+ LK+ + + + L K + I R +E A
Sbjct: 225 YRRL-----ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 279
Query: 2022 QQRLRVFNQLEDELNSHEH-ELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRL 2080
L +++ +L + EH C ++ K KQ+ AF E+ N++E ++L
Sbjct: 280 DSILVWLTEMDLQLTNIEHFSECDVQAKIKQLK----AFQQEISLNHNKIEQIIAQGEQL 335
Query: 2081 IHENQGQCCGLIDLMREYQNLKSAVSKV---LENASSVIVTRTTIKDQEDL--KWAFSKH 2135
I +++ +I+ E L+ +V +E ++ D+ DL + +
Sbjct: 336 IEKSEPLDAAIIE--EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELED 393
Query: 2136 ETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVD----KW---LDV 2188
A + +++ + D+ S L D ++VD +W D+
Sbjct: 394 SAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 453
Query: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFE 2248
S LE M R L + DE + + A +S++ E +K E
Sbjct: 454 SRDLESAMSR----------ALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTE 503
Query: 2249 SEVKNKALRLEELHSKVNDLKELTKNLETPP-DLQFIEADLMQKLEHAKEITEVAKGTLK 2307
+ +KN + L S++ ++L K L+ +Q E + K E+ KG +K
Sbjct: 504 NAIKNTSGDHSALESQI---RQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMK 560
Query: 2308 DFTAQSTQVEKFINDITTWFTKVEESL---MNCAQNET-------------CEALKKVKD 2351
S+ ++ + + + EESL +N ET +AL K
Sbjct: 561 LLGECSSSIDS-VKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELR 619
Query: 2352 IQKELQS-QQSN---------ISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVS- 2400
+++ LQ QQ N + T+E L L R S +++++ + L + +AV
Sbjct: 620 MKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDH 679
Query: 2401 --------QLCSK--TQASLQES 2413
LCS TQA +ES
Sbjct: 680 RKAIILSINLCSPEFTQADSKES 702
Score = 46.6 bits (109), Expect = 0.001
Identities = 157/826 (19%), Positives = 311/826 (37%), Gaps = 150/826 (18%)
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
M ++A H+ A+E+E K G++ HL L L+ + + +E
Sbjct: 1 MGERLAKASHESKASEIEYKLGKVNDRWQHL-----------LDLIAARVKK----LKET 45
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
V++ +S L + L+ I +L + + +S N E I++ LN+ +
Sbjct: 46 LVAVQQLDKNMSSLRTW------LAHIESELAKPI-VYDSCNSEE---IQRKLNEQQELQ 95
Query: 1924 KALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATA-DQLCGEVERIQNLLGTKQSEADA 1982
+ +E + + +L+ + L C A A D C +++ L + A
Sbjct: 96 RDIEKHSTGVASVLNLCEVLLH--------DCDACATDAECDSIQQATRNLDRRWRNICA 147
Query: 1983 LAVLKKAFQDQKEELLKSIEDIEERTDKERLK-EPTRQALQQRLRVFNQLEDELNSHEHE 2041
+++ + RLK E T + Q+ L +++ ED L S E
Sbjct: 148 MSM------------------------ERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 183
Query: 2042 LCW------LKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ-GQCCGLIDL 2094
+ + AK+ +K AF +V + +LE+ +RL EN+ C L +
Sbjct: 184 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQM 243
Query: 2095 MRE----YQNLKSAVSKVLENASSVIVTRTTIKDQED--LKWAFSKHETAKNKMNYKQKD 2148
+ E + NL+ V+ +L I R + D L W +M+ + +
Sbjct: 244 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWL--------TEMDLQLTN 295
Query: 2149 LDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK--------LEENMDRLR 2200
+++F+ + K + SL +E + + + EK +EE +D LR
Sbjct: 296 IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 355
Query: 2201 -----------------VSLSIWDDV--LSTRD-EIEG--------WSNNCV-----PQM 2227
+ L + DD LS R+ E+E W + PQ
Sbjct: 356 RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 415
Query: 2228 AENIS-NLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKEL------TKNLETPPD 2280
+ N+S +L LR+E ++ + V + L + + DL+ +++ E D
Sbjct: 416 SSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDD 475
Query: 2281 LQFI--------EADLMQKLEHAKEITEVA-KGTLKDFTAQSTQVEKF--INDITTWFTK 2329
F + + + E ++TE A K T D +A +Q+ + D + + +
Sbjct: 476 KDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ 535
Query: 2330 VEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHS----AELESL 2385
E+++ E K K L S+I S + + L + S L S
Sbjct: 536 QTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHST 595
Query: 2386 GRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESSDR- 2442
G+I + E + + ++++L+K F+ + W LG E R
Sbjct: 596 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW-LGDTEEELEQLQRL 654
Query: 2443 --TGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKAN 2500
+ D + +E ++ L+ + +V ++ + ++ SK+ +Q+++++ N
Sbjct: 655 ELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE-SRDLQDRLSQMN 713
Query: 2501 EEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFN 2546
+ + + LQD + F + L L + ++ R N
Sbjct: 714 GRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
Score = 45.1 bits (105), Expect = 0.003
Identities = 81/372 (21%), Positives = 159/372 (42%), Gaps = 52/372 (13%)
Query: 1351 RFETNK-ETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE 1409
RF+ + E ++R TG E S+ L E + + KR E + +KE
Sbjct: 531 RFQIQQTENIIRSKTPTGP--ELDTSYKGYMKLLGECSSSIDSVKRLE-------HKLKE 581
Query: 1410 ASEIPLGPQNKQLLQQQAKSIKEQVKKLE-DTLEEDIKTMEMVKTKWDHFGSNFETLSVW 1468
E G N + Q + ++ + L+ L ++++ + ++ KW F S+ ++ W
Sbjct: 582 EEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQ-KWQQFNSDLNSIWAW 640
Query: 1469 ITEKEKELNALE-----TSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTT 1523
+ + E+EL L+ T +++QI ++K + ++ + + I+ + + F Q +
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ-ADS 699
Query: 1524 GESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEE---NLRKIQQSVSEFED 1580
ES ++ +L+Q+ + + + G + L Q Q F E L + +++ ++
Sbjct: 700 KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKN 759
Query: 1581 KLAVPIKICSSATETYKVLQEHMDLC-----QALESLSSAITAFSASARKVVNRDSCVQE 1635
++ VPI A ++LQ+H + LES + S + +VN +
Sbjct: 760 EI-VPIDSNLDA----EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEG---- 810
Query: 1636 AAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDI--- 1692
D L AKE+ + N L + L KE+S + LE+ SS + D+
Sbjct: 811 --------TDCL-EAKEKVHVIGNRL---KLLLKEVSRHIKELEK-LLDVSSSQQDLSSW 857
Query: 1693 -SADRVKVEGEL 1703
SAD + G +
Sbjct: 858 SSADELDTSGSV 869
Score = 41.6 bits (96), Expect = 0.035
Identities = 46/220 (20%), Positives = 81/220 (36%), Gaps = 45/220 (20%)
Query: 585 EEAENVMKFMN----ETTA-----QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAW 635
EE E++ F+N ET +W L + S +++ + W ++ + + S+ AW
Sbjct: 581 EEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAW 640
Query: 636 LEDAEKMLNQSENAKKDF-----------FRNLPHWIQQHTAMNDAGNFL---IETCDEM 681
L D E+ L Q + + + L + A+ + N D
Sbjct: 641 LGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSK 700
Query: 682 VSRDLKQQLLLLNGR----------WRELFMEVKQYAQA------------DEMDRMKKE 719
SRDL+ +L +NGR WR L + Q + +DR K E
Sbjct: 701 ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNE 760
Query: 720 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDI 759
L A + H K ++ + +L + L+D+
Sbjct: 761 IVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDM 800
Score = 40.0 bits (92), Expect = 0.10
Identities = 50/269 (18%), Positives = 111/269 (41%), Gaps = 33/269 (12%)
Query: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMS-GLGSV 7522
++W+ + +A + + +++WQ++ + WL ++ L +S + ++
Sbjct: 604 DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTI 663
Query: 7523 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7582
+ +++ + L V ++ + IL++ ADS LQ L+++ +
Sbjct: 664 ELQIKKLKELQKAVDHRKAI--------ILSINLCSPEFTQADSKESRDLQDRLSQMNGR 715
Query: 7583 WKSASMRLEEQKKKLAFLL---KDWEKCEKGIADSLEKLRTFKKKL--------SQSLPD 7631
W LEE + L L + + + G+ LE + K ++ ++ L D
Sbjct: 716 WDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQD 775
Query: 7632 HHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELL----Q 7687
HH++L + E + V S D QL + + + + + ++ R++LL
Sbjct: 776 HHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVS 835
Query: 7688 RQWEELCHQLSLRRQQIGERLNEWAVFSE 7716
R +EL L + Q + L+ W+ E
Sbjct: 836 RHIKELEKLLDVSSSQ--QDLSSWSSADE 862
Score = 39.3 bits (90), Expect = 0.17
Identities = 45/254 (17%), Positives = 104/254 (40%), Gaps = 12/254 (4%)
Query: 6932 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALK 6991
W++LQ K ++ L+ W ++ +++ + W E+ L+Q R+ +Q
Sbjct: 606 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 665
Query: 6992 DCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTLRELGQTWANLDHMVGQ 7049
+ L++L KA + I L + + D S + L ++ W + ++ +
Sbjct: 666 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 725
Query: 7050 LKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR----LLTGSLEA--VQVQVDNLQ 7103
+ LL+ L Q F +++ L+ ++ R + + +L+A +Q L
Sbjct: 726 WRGLLQDALMQCQ----GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 781
Query: 7104 NLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7163
++ +L + + + ++ QLL + + R LL+E++ ++
Sbjct: 782 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 841
Query: 7164 KALLQLWQRYKDYS 7177
+ LL + +D S
Sbjct: 842 EKLLDVSSSQQDLS 855
Score = 38.9 bits (89), Expect = 0.23
Identities = 53/276 (19%), Positives = 120/276 (43%), Gaps = 25/276 (9%)
Query: 1115 LRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDT---ANHGEVK 1171
L+A S ++ ++ KW+ + S + +W+ E +L+ ++ + T ++K
Sbjct: 609 LQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK 668
Query: 1172 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1231
+ ++E++ V R + + T+ S+ E++ D L++++ + + +LL E
Sbjct: 669 K-LKELQKAVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEW 726
Query: 1232 EKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTK 1290
+L + C + E+ L L + + + +I+ ++ +A+ L HH+Q +
Sbjct: 727 RGLLQDALMQCQGFHEMSHGLLLML----ENIDRRKNEIVPIDSNLDAEILQDHHKQLMQ 782
Query: 1291 RISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ--ERRIQVTLRK 1348
++ ++ ++Q L D + L E T D LE + R+++ L++
Sbjct: 783 --------IKHELLESQLRVASLQDMSCQLLVNAEGT-DCLEAKEKVHVIGNRLKLLLKE 833
Query: 1349 WERFETNKETVVRYLFQTGSSHERFLSFSSLESLSS 1384
R E L SS + S+SS + L +
Sbjct: 834 VSRHIKELEK----LLDVSSSQQDLSSWSSADELDT 865
Score = 37.0 bits (84), Expect = 0.86
Identities = 62/365 (16%), Positives = 136/365 (37%), Gaps = 17/365 (4%)
Query: 7340 DRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWME 7399
+RL + + ++ E K + +N W + R KL+ L+ Q + +
Sbjct: 3 ERLAKASHESKASEIEYK-LGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRT 61
Query: 7400 FLVQTEQKLAVEI---SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV 7456
+L E +LA I S N + + + + Q ++ + S++ + LL
Sbjct: 62 WLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDA 121
Query: 7457 ----DDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS 7512
+ D L +W+ + + +RR I+ R WQ++ + + WL
Sbjct: 122 CATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKS-- 179
Query: 7513 YLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE----AGKQLLLSADSGA 7568
+ P T+ E K + F RQ + +E ++L + +
Sbjct: 180 ---SERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDS 236
Query: 7569 EAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS 7628
+L+ + E ++W + R+ ++L + E+ E L L +L+
Sbjct: 237 ACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNI 296
Query: 7629 LPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQR 7688
++ A+ + K + + + + Q+ + L D +I+ E ++ L+R
Sbjct: 297 EHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRR 356
Query: 7689 QWEEL 7693
+E+
Sbjct: 357 YCQEV 361
Score = 37.0 bits (84), Expect = 0.86
Identities = 59/369 (15%), Positives = 151/369 (40%), Gaps = 43/369 (11%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWL--------- 636
+A + + + +W++L + + L+E + + ++SL+ WL
Sbjct: 13 KASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK 72
Query: 637 ---------EDAEKMLNQSENAKKDFFRNLPHWIQQHT----AMNDAGNFLIETCDEMVS 683
E+ ++ LN+ + ++D I++H+ ++ + L+ CD +
Sbjct: 73 PIVYDSCNSEEIQRKLNEQQELQRD--------IEKHSTGVASVLNLCEVLLHDCDACAT 124
Query: 684 ----RDLKQQLLLLNGRWREL-FMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKL 738
++Q L+ RWR + M +++ + +E R+ +++ D + + +
Sbjct: 125 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 184
Query: 739 SEPLE--VSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
+ P V + K ++ E +++V Q ++I K + +E+ + + +
Sbjct: 185 AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMV 244
Query: 797 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 856
+ ++ +++ + +L + + EE E S L +++ +T +E ++
Sbjct: 245 HEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDV 304
Query: 857 LFKQKHQELLACQE----NCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIH 912
+ K ++L A Q+ N K +I +G Q ++K L + + L+R ++
Sbjct: 305 --QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVF 362
Query: 913 VAFQSMVKK 921
+ KK
Sbjct: 363 GRVERYHKK 371
Score = 36.2 bits (82), Expect = 1.5
Identities = 139/775 (17%), Positives = 298/775 (38%), Gaps = 106/775 (13%)
Query: 1409 EASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLS 1466
+ASEI LG N + Q I +VKKL++TL + ++ K N +L
Sbjct: 13 KASEIEYKLGKVNDRW-QHLLDLIAARVKKLKETL---VAVQQLDK--------NMSSLR 60
Query: 1467 VWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS-IVGLEEEAQSFAQFVTTGE 1525
W+ E EL S +I + QE++ + G+ + +
Sbjct: 61 TWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCD 120
Query: 1526 SARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLR---KIQQSVSEFEDKL 1582
+ A+ I++ L + + + ++ K EE R K S FED L
Sbjct: 121 ACATDAECDSIQQATRNLDRRWRNICAM---SMERRLKIEETWRLWQKFLDDYSRFEDWL 177
Query: 1583 AVPIKIC---SSATETYKVLQEHMDLCQALE-SLSSAITAFSASARKV--VNRDSCVQEA 1636
+ SS+ Y V +E + +A + + +T ++ + R++ A
Sbjct: 178 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 237
Query: 1637 AALQQ-------QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPE 1689
+L+Q +++++ +R L++ + + E S L WL + + ++ E
Sbjct: 238 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE 297
Query: 1690 MDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQL 1749
D V+ +++ ++A Q E+ + +++ E L + D +++ E+L
Sbjct: 298 HFSECD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE---EEL 351
Query: 1750 DERWRDLPQIINKRINFLQSVVA------EHQQFDELL-------LSFSVWIKLFLSEL- 1795
DE R ++ + + + ++ EH D L LS W L
Sbjct: 352 DELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLL 411
Query: 1796 --QTTSEISIMDHQVALTRH--KDHAAEVES----------KKGELQSLQGH-LAKLGSL 1840
Q +S +S+ Q + +D A V+S +L+S L
Sbjct: 412 SPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEE 471
Query: 1841 GRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEA 1900
G+ + L+G + E+ + + L + + H++L +RQL + ++
Sbjct: 472 GQDDKDFYLRGAVGLSDVMIPESPEAYVK--LTENAIKNTSGDHSALESQIRQLGKALDD 529
Query: 1901 TNSMNKNESDLIEK------DLNDALQN-AKALESAAVSLDGILSKAQYHLK-------- 1945
+ + ++I +L+ + + K L + S+D + + ++ LK
Sbjct: 530 SRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSV-KRLEHKLKEEEESLPG 588
Query: 1946 ---IGSSEQRTSC------RATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEE 1996
+ S+E +T+ A L E+ QNL +Q +D ++ A+ EE
Sbjct: 589 FVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIW--AWLGDTEE 646
Query: 1997 LLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKD 2056
L+ ++ +E TD Q ++ +++ +L+ ++ + + + + + Q D
Sbjct: 647 ELEQLQRLELSTDI--------QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQAD 698
Query: 2057 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLEN 2111
+ ++ ++++ WD L+ E +G + + + + + +LEN
Sbjct: 699 SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 753
Score = 35.4 bits (80), Expect = 2.5
Identities = 53/282 (18%), Positives = 123/282 (43%), Gaps = 29/282 (10%)
Query: 2711 QTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIE--HPLQ 2768
+TQ + + W + + ++ + ++ + +W + N + W+ ++++E L+
Sbjct: 596 ETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE 655
Query: 2769 PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQF 2828
++ + + L+ L +A DH +A+ +++ + E T+ +S + ++ +Q
Sbjct: 656 LSTDIQTIELQIKKLKE-LQKAVDHRKAI--ILSINLCSPEFTQADSKESRDLQDRLSQM 712
Query: 2829 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWS------DMSGDSSA 2882
N + + +++D LM HE + L E + R D + D+
Sbjct: 713 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEI 772
Query: 2883 TQ---KKLSKIK-ELIDSREIGASRLSRVESLAPEVKQNTTASGC----ELMHTEMQALR 2934
Q K+L +IK EL++S+ R++ ++ ++ ++ N + C E +H L+
Sbjct: 773 LQDHHKQLMQIKHELLESQ----LRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLK 828
Query: 2935 ADWKQWEDSVFQTQSCLENLVSQMALS------EQEFSGQVA 2970
K+ + + + L+ SQ LS E + SG V+
Sbjct: 829 LLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVS 870
>gi|33624873 spectrin repeat containing, nuclear envelope 2 isoform 4
[Homo sapiens]
Length = 556
Score = 363 bits (932), Expect = 4e-99
Identities = 241/608 (39%), Positives = 330/608 (54%), Gaps = 70/608 (11%)
Query: 8158 LEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHD 8217
+ED + W R S +PSS SL ERSG +TP SVDSIPLEWDH
Sbjct: 1 MEDPREIQTDSWRKRGE----SEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWDHT 56
Query: 8218 YDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTS 8277
D+ + EDEEG +Y LSDV IPE+PEAY+K+T +K +S
Sbjct: 57 GDVG-------GSSSHEEDEEGP----YYS----ALSDVEIPENPEAYLKMTTKTLKASS 101
Query: 8278 GDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK---GYMKLLGECSS 8334
G S + + + +Q E R+ P P T YK G + L
Sbjct: 102 GK-SISDGHSWHVPDSPSCPEHHYKQMEGD-RNVPPVPPASSTPYKPPYGKLLLPPGTDG 159
Query: 8335 SIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKW 8394
+ + L ++E+ L G Q +G DRWE++QAQ L +L++KQNLQ
Sbjct: 160 GKEGPRVLNGNPQQEDGGLAGITE------QQSGAFDRWEMIQAQELHNKLKIKQNLQ-- 211
Query: 8395 QQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSI 8454
Q NSD+++I WL TE ELE L+ + +DIQ IEL++K+L+E+ KA D KA+++S+
Sbjct: 212 -QLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSV 270
Query: 8455 NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQG-------- 8506
N+ S EF Q +S ES +LQ RL Q++ W+ ++ WRG L+ +LMQCQG
Sbjct: 271 NVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSD 330
Query: 8507 ------FHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLR 8560
FH++S LLL L + R+ + D D L + ++LMQ++ EL+E Q +
Sbjct: 331 VLFFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQ 390
Query: 8561 VASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD 8620
V LQ++S LL+ G DC+EA+EKVHVI +LK L ++VS + L+ + +Q
Sbjct: 391 VDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVS------QDLMALQGTQNP 444
Query: 8621 LSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSL 8680
S S DE+D SG P + P R K R R+T+G ++
Sbjct: 445 ASPLPSFDEVD-SGDQPPATSVPAP-RAKQFRA---------------VRTTEGEEETES 487
Query: 8681 SEPGPGRSGRGFLFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSFHPML 8740
PG R R FL RV+RAALPLQLLLLLL+ LACL+P SEEDYSC +NNFARSF+PML
Sbjct: 488 RVPGSTRPQRSFLSRVVRAALPLQLLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPML 547
Query: 8741 RYTNGPPP 8748
RYTNGPPP
Sbjct: 548 RYTNGPPP 555
Score = 40.0 bits (92), Expect = 0.10
Identities = 59/295 (20%), Positives = 118/295 (40%), Gaps = 20/295 (6%)
Query: 5838 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5897
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 157 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 213
Query: 5898 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 5952
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 214 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 273
Query: 5953 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6012
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 274 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 332
Query: 6013 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6067
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 333 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 392
Query: 6068 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGT 6122
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 393 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGT 441
Score = 36.2 bits (82), Expect = 1.5
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 7793 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7847
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 190 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 242
Query: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASV 7875
+EI+ ++ QE+ + + + V SV
Sbjct: 243 IQEIELRVKRLQEILKAFDTYKALVVSV 270
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 355 bits (911), Expect = 1e-96
Identities = 782/4225 (18%), Positives = 1652/4225 (39%), Gaps = 574/4225 (13%)
Query: 4221 IEDLKDQKQKMIEHLNLDDKE--LVKEQTSHLEQRWFQLEDLIKRKI------------- 4265
+E K + Q +++ + +DKE + K S L+ +LE+ +R +
Sbjct: 1022 VEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDR 1081
Query: 4266 ---QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQ------NLL--- 4313
Q + + E Q Q+L + L QSP NLL
Sbjct: 1082 DAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEK 1141
Query: 4314 MDHL-----AICSELEAKQMLLKSLIKDADRVMA--DLGLNERQVIQKALSDAQSHVNCL 4366
MDH+ ++L+ ++++S I+DA+ ++ ++ L++ +V+ LS ++H + L
Sbjct: 1142 MDHVYGLSTVYLNKLKTVDVIVRS-IQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTL 1200
Query: 4367 SDLVG--QRRKYLNKALSEKTQFLMAVFQATSQIQQHERKI---MFREHICLLPDDVSKQ 4421
+ + + + L E+ V + S++ ER + ++E L + +
Sbjct: 1201 RHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTP-ERNLDLERYQEKGSQLQERWHRV 1259
Query: 4422 VKTCKSAQASLKTYQNEVTGLWAQGRELMK---EVTEQEKSEVLGKLQELQSVYDSVLQK 4478
+ + Q+ L++ Q + A L+K E T Q++ G+ ++ + + + + Q+
Sbjct: 1260 IAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQ 1319
Query: 4479 CSHRLQELEKNLVSRKHFKEDFDKACHWLKQ-ADIVTFPEINLMNESSELHTQL---AKY 4534
+ E+E+N + D+ + +Q + IV E+ LM + + +Q K
Sbjct: 1320 TA-LFAEIERN-------QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKR 1371
Query: 4535 QNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYK 4594
+ +L S + L RT T L +L Y+S+ L L + V+ ++ K
Sbjct: 1372 RRMLSSSDAITQEFMDL-RTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEK 1430
Query: 4595 VQEAI-----LARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAIL 4649
V+E + LAR T+ +++E L + +L ++ + + +
Sbjct: 1431 VKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKE-QVSEAIKTSQ 1489
Query: 4650 DEVAGLGEAVDELNQKK--EGFRSTGQPWQP---DKMLHLVTLYHRLKRQTEQRVSLLED 4704
+A G + E +K+ E + + + L L +L QTEQ+ +L +
Sbjct: 1490 IFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQK-TLQKQ 1548
Query: 4705 TTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQDSGI 4759
+ +Q+ E +C + + +++ Q + ++ L A +K + + +
Sbjct: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFAT 1608
Query: 4760 VLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
V+K + +E+ L P R ++ + + + L E E + ++ +
Sbjct: 1609 VVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQE 1668
Query: 4820 TEMSRS--------------LDWLRRVKA-------------ELSGPVYLDLNLQDIQEE 4852
TE S++ LDW+ V + +LSG L+ D +
Sbjct: 1669 TEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSG-ASLEKGALDTTDG 1727
Query: 4853 IRKIQIHQEEVQSSLRIMNALSHK---EKEKFTKAKELISADLE---HSLA--------- 4897
+ E++ +M A + +++ F A + A L+ H+L
Sbjct: 1728 YMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQ 1787
Query: 4898 ELSELDGDIQEALRTRQATLTEIYS---QCQRYYQVFQAANDWLEDAQELLQLAGNGLDV 4954
+L EL +L +A L ++ + + Q++ Q + WLE +++ L+ G
Sbjct: 1788 KLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSS 1847
Query: 4955 ESAEENLKSHMEFFSTEDQFHSN------------LEELHSLVATLDP-----LIKPTGK 4997
+L FS + H L+ +S +P L+K K
Sbjct: 1848 PETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLK 1907
Query: 4998 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREE-----------VIELM 5046
D ++ +L + R+ G+ +++L Q+H +Q + + V +L+
Sbjct: 1908 -DATERYTALHSKCTRL----GSHLNML---LGQYHQFQNSADSLQAWMQACEANVEKLL 1959
Query: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
+DT + +++ + +E+L+EH+ V + I+ +E + + + + +
Sbjct: 1960 SDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETT 2019
Query: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
+ LS + + ++ +L+ A+ + ++ + I +++ L G
Sbjct: 2020 DSILSHFQSLSYS--------LAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
Query: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
S + L + ++ +Q+S+L R+ ++ + T + E+
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2131
Query: 5227 TA-MQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIEI 5282
+ + CL QEK + KL+ Q EM E ++ +++ L + P +I
Sbjct: 2132 SQRFEQLCLQQQEKESSLKKLLPQA----EMFEHLSGKLQQFMENKSRMLASGNQPDQDI 2187
Query: 5283 DAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDL------ 5336
+++Q L E + ++N++ + L +ELS ALDL
Sbjct: 2188 THFFQQIQELNLEMEDQQENLDTLEH------------LVTELSS--CGFALDLCQHQDR 2233
Query: 5337 -----KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK---TDNVVQAK 5388
K ++Q +KE E+ ++ QE + +KL + L + + T+ + AK
Sbjct: 2234 VQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAK 2293
Query: 5389 TDQKVL-------------GEELDGCNSKLMELDAAVQKFL--EQNGQLGKPL---AKKI 5430
+K + G ++ N K L+ + + + G+ G L +
Sbjct: 2294 ELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSV 2353
Query: 5431 GKLTELHQ-QTIRQAENRLSKLN----QAASHLEEYNEMLELILKWIEKAKVLAHGTIAW 5485
G + H + + + + +S +N + L E E L+ IL +E+ A+ + W
Sbjct: 2354 GSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQW 2413
Query: 5486 NSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEEL 5545
LE +E+ ++AM+ + T E +AEL + + ++
Sbjct: 2414 ----------------LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKI 2457
Query: 5546 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRL-SLKEQLSHRQHL 5604
Q +K L L + ++ E KK+Q L T V R L+E SH
Sbjct: 2458 -QKVKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVARQRQLEESASHLACF 2515
Query: 5605 LSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQA 5664
+ L+P + +L V+ L + L Q++ +Q
Sbjct: 2516 QAAESQLRPWLMEKELMMG-------VLGPLSIDPNMLNAQKQQ-------------VQF 2555
Query: 5665 AVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ-ELQAQISRHEELAQKIKG---- 5719
+ ++E Q+ + L + +G D ++TS +Q ELQ+ + EL K+
Sbjct: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615
Query: 5720 ----------YQEQIASLNSKCKMLTMKAKHATMLLTVTE-VEGLAEGTEDLDGELLPTP 5768
YQE + L+ K + + + + + T E V+ E T ++ +L
Sbjct: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL---- 2671
Query: 5769 SAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYY 5828
+ TL ++ GE+ E+ +V +
Sbjct: 2672 ----EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE------------TVALPLQGL 2715
Query: 5829 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY 5888
+ L+A+R+ ++ + +++Q+F + + D R+W
Sbjct: 2716 EDLAADRIN----RLQAALASTQQFQQ----------MFDELRTW--------------- 2746
Query: 5889 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 5948
L+ +Q Q IS K+E ++ +L E+ E +S ++ ++ E
Sbjct: 2747 --LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE---------- 2794
Query: 5949 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6008
E L+ + E+ LQ+ L L + K + ++ L++ +
Sbjct: 2795 -----GESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKKTADRQSRLKDCM------- 2840
Query: 6009 RQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVA 6068
Q Q+Y+ ++L W+ KA + + L +P+ +E+ L+ + ML E+E++
Sbjct: 2841 ---QKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 2896
Query: 6069 LSEL----------SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLN 6118
L L S +E+ + + KA + + +L+ GSL E+ + L + Q +
Sbjct: 2897 LEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQES 2956
Query: 6119 MQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLR 6178
+ ++ E + L + G Q + + L+ Q+E+ Q L Q LR
Sbjct: 2957 FKNIEKKVEGAKHQLEIFDALGSQ--------ACSNKNLEKLRAQQEVLQALEPQVDYLR 3008
Query: 6179 SVASRGEEILIQHSAAETSGDAGE---KPDVLSQE-LGMEGEKSSAEDQMRMKWESLHQE 6234
+ E A DA + + +V QE L ++ +S M K E + Q
Sbjct: 3009 NFTQGLVE------DAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQF 3062
Query: 6235 FSTKQKLLQNVLEQEQE--------------QVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6280
+++ + + + E Q L+ + + K D+ +
Sbjct: 3063 HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECR 3122
Query: 6281 TSL-------LDGLNQAFEEVSSQSGG------AKRQSIHLEQKLYDGVSATSTWLDDVE 6327
L L GL + E ++ Q G A+++ + L + L+D
Sbjct: 3123 HMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDAT 3182
Query: 6328 ERLFVATALL-PEETETCLFNQEIL------AKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
A AL TE + NQ++ + + + ++ + L G +
Sbjct: 3183 TAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC 3242
Query: 6381 DV--IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL- 6437
DV +E + + R + L+ V QR Q++E L FQ+ L+ L + LAD + +I
Sbjct: 3243 DVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN 3302
Query: 6438 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDK------LQVEQPSMQELSK 6491
QK + + V QI+ + + L + A + L+ G + L + +L
Sbjct: 3303 QKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLES 3362
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
L+ + EL+ +R+ L L L Q+ + ++D L ++K+A + + + +
Sbjct: 3363 LESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK- 3421
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFR---KIISFAVQKETQFHTE----LMAQASAVLK 6604
IQQ + +HK + +E+H + + S E +E L A+ S +
Sbjct: 3422 IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQD 3481
Query: 6605 RAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHL 6664
R ++ L+ L ED+ E+ L VE + SV + + +D L + + L
Sbjct: 3482 RCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLAL 3541
Query: 6665 KSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLET 6721
+ + + Q + +G+ LL + + ++ +L+ + + T SK L LE
Sbjct: 3542 NEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQ 3601
Query: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
+ T++QS +L WL+ ++ L QS T Q + F + KE+ +
Sbjct: 3602 ARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ--------IPQFQQRQKELKKE 3653
Query: 6782 SSLKSSVLSTGNQLLR-LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
VL T N++ R L ++ R L ++ S D V + + Q ++D++
Sbjct: 3654 VMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS---DANEQYKLVSDTIGQ-RVDEID 3709
Query: 6841 S--------RHAISEVMSWIS------LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFK 6886
+ A ++W++ + I+ ++D LQ K F
Sbjct: 3710 AAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ---------LQVQKAFS 3760
Query: 6887 IDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLL 6946
IDI + ++D + +I E + KT E+ ++ + ++ + L +E+ L
Sbjct: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQ---KTVLQEKTESLIQQYEAISLLNSERYARL 3817
Query: 6947 EGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEK 7005
E +++ + L W E + Q D ++ ++ + L + I +
Sbjct: 3818 ERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKP 3877
Query: 7006 EVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHK 7065
++K+ + G L + E+ +V ++ +A + V Q + L + Q +
Sbjct: 3878 HIDKLLKIGPQLKELNPEE-GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQIT 3936
Query: 7066 VAFDKINSYLMEARYSLSRFR---LLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI 7122
DKI L SR R L+ ++ ++ + + ++ +LEK + S +
Sbjct: 3937 EFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRR 3996
Query: 7123 TNQLLKECHPP----VTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSK 7178
+L+ + + + L ++ W ++ E+ +L+L +++
Sbjct: 3997 GEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMA 4056
Query: 7179 QCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7238
+T++ +D ++L + I +V + + + + + L F+ LG
Sbjct: 4057 ALLTTIKDTQDIVHDLESPGIDPSIIKQQV----EAAETIKEETDGLHEELEFIRILGAD 4112
Query: 7239 LKQQVDASAASAIQSDQLSLSQHLCALE-------QALCKQQTSLQAGVLDYETFAKSLE 7291
L + A + + S+ + A E + L K + ++QA V +T +
Sbjct: 4113 L---IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFD 4169
Query: 7292 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-- 7349
L+ +++ + P +DL+T+++++ E+K ++ ++++LN G +
Sbjct: 4170 WLDNTVIKLCTM-----PPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224
Query: 7350 ---PLNDKEIKR--MQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQT 7404
D++I R + L W + + R KL+ LL F E M +L T
Sbjct: 4225 KATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHT 4284
Query: 7405 EQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 7462
E+ L + ISG+ + + + H + + ++ + Q + ++ G LLE DD
Sbjct: 4285 EELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSL 4344
Query: 7463 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV 7522
+L ++ W+ V+++ ++R + S ++Q Q + ++ +L+E++ + S
Sbjct: 4345 RSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS---EIEDFLLELTRMESQLSASK 4401
Query: 7523 P---IPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD-SGAEAALQAELAE 7578
P +P L ++ ++ +++ +Y ++ G+ +LLS D SG+ + + +A
Sbjct: 4402 PTGGLPETAREQLDTHMELYSQLKAKEE-TYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL 4460
Query: 7579 IQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHH--EEL 7636
+++KW S ++EE+K KL L + + + + + L ++ L+ + P +
Sbjct: 4461 LEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV 4520
Query: 7637 HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQ 7696
++ K N V + D + +L + L D+ ++ + +Q +WE++ +
Sbjct: 4521 LSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQR 4580
Query: 7697 LSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIA 7756
R + + + F E K+L +WL ES + +I + KL+ +E
Sbjct: 4581 SIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQ 4640
Query: 7757 IAQENKIQLQQMGERLAKASHESK-----ASEIEYKLGKVNDRWQHLLDLIAARVKKLKE 7811
K + R +A E + +++ LG+V D+W + R KL+E
Sbjct: 4641 KTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEE 4700
Query: 7812 TLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7869
L+ Q + +L WL +E +LA+ P+ D + + ++ + Q+++ K
Sbjct: 4701 ALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL---DLVMNLMDAHKVFQKELGKR- 4756
Query: 7870 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETW 7927
TG VL E++ + D + ++ + L RW +C +S+ ++ ++E+
Sbjct: 4757 TGTVQVLKRSGRELIENSRD------DTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQAL 4810
Query: 7928 RLWQKFLDDYSRFEDWLKSSERT----AAFPSSSGVIYTVA---KEELKKFEAFQRQVHE 7980
+ + F D +WL +E+T A P + + ++ KE +KK E + V+
Sbjct: 4811 KQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNS 4870
Query: 7981 CLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQRE 8040
+ E+I D ++K + R++ + +RL+ + +
Sbjct: 4871 AVAMGEVI-------LAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELV 4923
Query: 8041 EFETARDSILVWLTEMDLQL---------TNIEHFSECDVQAKIKQLKAFQQEISLNHNK 8091
+ +L W+ + L NI+ V+A I + + F +E++
Sbjct: 4924 ANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR-----VKALIAEHQTFMEEMTRKQPD 4978
Query: 8092 IEQIIAQGEQLIEKSEPLDAAIIEE 8116
++++ ++ + EP A IE+
Sbjct: 4979 VDRVTKTYKR--KNIEPTHAPFIEK 5001
Score = 337 bits (864), Expect = 3e-91
Identities = 715/4063 (17%), Positives = 1589/4063 (39%), Gaps = 513/4063 (12%)
Query: 1902 NSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQ 1961
N++ E + ++DL Q L++ ++ D L ++ SS + R+ +
Sbjct: 1087 NALRIAEQEHTQEDLQ---QLRSDLDAVSMKCDSFLHQSP------SSSSVPTLRSELNL 1137
Query: 1962 LCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQAL 2021
L +++ + L ++ + V+ ++ QD ELL ++ E + +E + AL
Sbjct: 1138 LVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDA--ELL--VKGYEIKLSQEEVVLADLSAL 1193
Query: 2022 QQRLRVFNQLEDELNSHEHELCWLKD---KAKQIAQKDVAFAPEVDREINR-------LE 2071
+ ++ L + KAK +A++ PE + ++ R L+
Sbjct: 1194 EAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
Query: 2072 VTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWA 2131
W + Q + + +++ +Y+ + K +E T QE +K
Sbjct: 1254 ERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEE---------TTAQQEMMKPG 1304
Query: 2132 FSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK 2191
++ ++ +Q L + + L + +K S +S + D E + + E
Sbjct: 1305 QAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF-SQQYSTIVKDYELQLMTYKAFVES 1363
Query: 2192 LEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRA-EELLKEFESE 2250
+++ + R LS D + ++ V +++ + + LR EE K E E
Sbjct: 1364 QQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE 1423
Query: 2251 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2310
+ +++EL V+ L T+ T + KE T++ K L+
Sbjct: 1424 KQEHVEKVKELLGWVSTLARNTQGKATSSE--------------TKESTDIEKAILEQ-- 1467
Query: 2311 AQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL 2370
+ ++TT +V E++ + K K + ++ IS E L
Sbjct: 1468 ------QVLSEELTTKKEQVSEAIKT-------SQIFLAKHGHKLSEKEKKQIS---EQL 1511
Query: 2371 NSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL 2430
N+L + YH S + + SQL +T+ + + + +++ W
Sbjct: 1512 NALNKAYHDLCDGSANQLQ-------QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVG 1564
Query: 2431 GAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT-------QEGQTLY 2481
A+ A RT D L+ DL+++ D + + + V +E QT
Sbjct: 1565 QAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQT-- 1622
Query: 2482 AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEM 2541
LS + +++++E++ +A E+++A ++ ++ L++ + E + K
Sbjct: 1623 -KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA------- 1674
Query: 2542 EERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRGQLLSEEGH- 2596
+ L E+K+ I + V V G+LL +++LS ++G L + +G+
Sbjct: 1675 -----AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729
Query: 2597 GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------EALEEALQSM 2643
G Q + C + HQ LL + + +S Q L +H E + Q +
Sbjct: 1730 GVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKL 1789
Query: 2644 WFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL------------------------ 2678
+ LA +E+ L TL+ L + +QD
Sbjct: 1790 GELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPE 1849
Query: 2679 ----LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------VIQTQLETL 2717
L+K +G ++ KG+ + +S KEG+ +++ +L+
Sbjct: 1850 TLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDA 1909
Query: 2718 KEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP----QPG- 2772
E + + S S L ++ Q++ + + L+ WM++ + +E L PG
Sbjct: 1910 TERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGV 1969
Query: 2773 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQEELKTQFNDI 2831
L+E+ LQ L+E + L ++ E+ E D + + + F +
Sbjct: 1970 LQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSL 2029
Query: 2832 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS--- 2888
E+ +++ + +++ + ++ L S S Q+ L+
Sbjct: 2030 SYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNM 2089
Query: 2889 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2948
K+K+ I ++ + + E +TTA+ +Q A+ Q + + Q
Sbjct: 2090 KLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQRFEQLCLQQ 2142
Query: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008
E+ + ++ + F +L+Q +E S +L + G D++I + +
Sbjct: 2143 QEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPDQDITHFFQQ 2193
Query: 3009 GQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQ 3066
QE+ ++ + + L+ + EL C F+ DL + +V L K++ L + +
Sbjct: 2194 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2253
Query: 3067 NKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENG 3124
+ +Q FRK R FQ+WL + + + + E+ ++ ++ L + +
Sbjct: 2254 DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASK 2312
Query: 3125 QHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN---------- 3167
+ + KG L L+ + A Q K V ++ +H+
Sbjct: 2313 GTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDM 2372
Query: 3168 -------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3214
LH+++ +L+ + +M++ A + WL E+++ S P
Sbjct: 2373 SDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL--KSMDAMSSP 2430
Query: 3215 AK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFRHRVSQLSSQ 3267
K + + + ++ L E+ P++ ++KE L + +++++ +L+S+
Sbjct: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSR 2490
Query: 3268 YLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRT 3327
+ + +T + +L+ + F +L+ W+ + M+ + D ++L+++
Sbjct: 2491 WERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQK 2550
Query: 3328 LKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDMWASLLSAGI 3385
+++ +L + + Q + + + +L + T +Q++LQS+ W L
Sbjct: 2551 QQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLN 2610
Query: 3386 RCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAELRDKTTMLGK 3438
SQ++ A+ K T YQ+ ++ S + ++ L+ + E +L + + +
Sbjct: 2611 SRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD 2670
Query: 3439 AKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQERAKEAVTKSE 3495
+ L+ EV +L + + V + E Y+ + L+ + + +++ A + + + +
Sbjct: 2671 LEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQ 2727
Query: 3496 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQAL 3555
+ Q++Q+ WL +Q + + + ++ L++ +E Q +
Sbjct: 2728 AALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGS 2787
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNNVVNKLRLME 3611
++ E ++ S P E R L++ L+ W+ + ++ +++ + + K + +
Sbjct: 2788 YEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQ 2847
Query: 3612 QKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESH--------VNSRMGCQ 3663
+ + W++ + K VT ++E R++ +L+E +NS
Sbjct: 2848 WHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL 2907
Query: 3664 ATQLTSRYQALLLQ---VLEQIKFLEEEIQ----SLEESESSLSSYSDWYGSTHKNFKNV 3716
+ + + + + + + EE+Q SLEE L + + + + K +
Sbjct: 2908 INSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGA 2967
Query: 3717 ATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEG-EAERL 3771
+++ D + K L+ L + ++ + R + V+ +G +A +L
Sbjct: 2968 KHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQL 3027
Query: 3772 RKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEIL------- 3824
+ ++ E+ V + +E L +F + + + +A+ + L
Sbjct: 3028 LHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIG 3087
Query: 3825 HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQL 3884
+ + ++ + + L+K L+ + + E + + E+ E L+L+ LK +++ L
Sbjct: 3088 RDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLG---LKRELEAL 3143
Query: 3885 QSDYQDLCSIGKAMMEE---------------------------------IAGFEDRLNN 3911
L GKA E+ + G E + N
Sbjct: 3144 NKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIIN 3203
Query: 3912 LQMKGDTLIG-QCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSR 3970
Q+ + + D LQ KL+Q V+ QG S C Q LEH++++ +R
Sbjct: 3204 QQLADFKMFQKEQVDPLQMKLQQ-VNGLGQGLIQSAGKDCDV-----QGLEHDMEEINAR 3257
Query: 3971 QDTLQQ---------------CQAWLSAVQP---------DLEPSPQPPLSRAEAIK-QV 4005
+TL + C + A++P +L + +PP + + +K Q+
Sbjct: 3258 WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQI 3317
Query: 4006 KHFRALQ---EQARTYLDLL----------CSMCDLSNASVKTTAKDIQQTE-------- 4044
+ + LQ + + +D+L + D + + + + + TE
Sbjct: 3318 QEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAAR 3377
Query: 4045 -QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ------QLQNMKRRHSELELNIA 4097
+ +E LV A+ + E I S L +++ ++Q RH LE +I
Sbjct: 3378 QKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI- 3436
Query: 4098 QNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL 4157
+N + V VK QS + + + V L++K +S + + + + D+ CR++ L
Sbjct: 3437 ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQAR-YSEIQDR---CCRKAALL 3490
Query: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLAL--ALQ 4215
++ L R + + V +L + + ++ D + +H + LAL +
Sbjct: 3491 ----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIV 3546
Query: 4216 ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEEL 4275
RK ++ Q +++ ++ L++E+ ++ R+ + + ++ +
Sbjct: 3547 NRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLA 3606
Query: 4276 NVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIK 4335
QS ++EL W E + +A + QSP + + E+ +++L ++ +
Sbjct: 3607 TKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNE 3666
Query: 4336 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4395
+ ++ + R+ + K +SDA +SD +GQR ++ A+ Q+ A
Sbjct: 3667 VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAEL 3726
Query: 4396 SQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTE 4455
+ + + +RK+M I L D + Q++ K+ + +++ + L++ E+ E
Sbjct: 3727 AWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGE 3786
Query: 4456 QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQ--ADIV 4513
++K+ + K + L Y+++ S R LE+ V F E +++ W+++ A I
Sbjct: 3787 EQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIA 3846
Query: 4514 TFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEK 4573
P + +E +L Q + + + E E++ + L + G L LN + + EK
Sbjct: 3847 QLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-LKELNPEEGEMVEEK 3903
Query: 4574 LNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIELTTQSLSELEAQFLRMSKVP 4630
+ I + + + EA+ E+ IE ++L L ++ +P
Sbjct: 3904 YQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIP 3963
Query: 4631 TDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ------PDKMLH 4683
++ + E +S L+++ EA+ ++ G RS G DK+
Sbjct: 3964 AEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG-RSQGADKDLAAKEIQDKLDQ 4022
Query: 4684 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPA--- 4740
+V + +K + E+R D + EK + L ++K+ Q V++ P
Sbjct: 4023 MVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
Query: 4741 ---EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLL 4797
+++++ ++ L+ + I DL + R I + L
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENL 4139
Query: 4798 TSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAELSGPVYLDLN-LQDIQEEIR 4854
E + + E M ++ +Q + DWL +K PV DLN ++D E++
Sbjct: 4140 NKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMK 4199
Query: 4855 --KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-LEHSLAELSELDGDIQEALR 4911
K++++Q++++ M L+H+ + KA + D + L EL L ++ E +
Sbjct: 4200 EFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIA 4254
Query: 4912 TRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----LAGNGLDVESAEENLKSHMEF 4967
RQ L ++ + WL +ELL ++G D + E L H
Sbjct: 4255 HRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG---DPKVIEVELAKH--- 4308
Query: 4968 FSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA--SLELRSQRMSRDSGAQVDLL 5025
H ++ + AT++ + K G E LE + LRS R+ + +L
Sbjct: 4309 -------HVLKNDVLAHQATVETVNK-AGNELLESSAGDDASSLRS-RLEAMNQCWESVL 4359
Query: 5026 QRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS---------HEAEEKLSEHKA 5076
Q+ + Q ++ ++ E L E + +++ S A E+L H
Sbjct: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHME 4419
Query: 5077 LVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMTTVWQRWTRLRAVAQDQEKIL 5135
L S + + E L +K + + +D+ S + +S+ + Q+W + + ++++ L
Sbjct: 4420 LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKL 4479
Query: 5136 EDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTF--------- 5186
E+A++ T F N +++ + + L +S +L+ +E H F
Sbjct: 4480 EEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRD 4539
Query: 5187 -VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245
++EL+Q + L L Q+ +L + + ++Q R + ++ G+
Sbjct: 4540 QIIELDQTGNQLKFLSQKQDVVL-------------IKNLLVSVQSRWEKVVQRSIERGR 4586
Query: 5246 LVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIE- 5304
+ K + + W+++ + +L + +EI +++++ L++ ++ +
Sbjct: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLSKHKEFQKTLGG 4645
Query: 5305 ---------KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIR-DQIQDKIKEVEQSKA 5354
+ KEK T+LP + S +L +++ + D + K E +
Sbjct: 4646 KQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699
Query: 5355 TSQELSRQIQKLAKDLTTILTKLKAK----------TDNVVQAKTDQKVLGEELDGCNSK 5404
+ S Q + L L K++ + D V+ KV +EL
Sbjct: 4700 EALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGT 4759
Query: 5405 LMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEM 5464
+ L + ++ +E + + ++ +L+ + + ++ S+L QA E + +
Sbjct: 4760 VQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 4819
Query: 5465 LELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE--ESKEID-SELEAMTEKLQ 5520
+ ++L+W+ +A + L + L+ H+ ++ E K +D + AM E +
Sbjct: 4820 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVIL 4879
Query: 5521 YLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA 5580
+ C + + + EE+ K Q L+ A ++ L++L A ++ A
Sbjct: 4880 AVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWA 4939
Query: 5581 QATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKVQAV 5618
+ TL + + +K ++ Q + EM +P V V
Sbjct: 4940 ETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 4982
Score = 328 bits (840), Expect = 2e-88
Identities = 869/4900 (17%), Positives = 1887/4900 (38%), Gaps = 668/4900 (13%)
Query: 2158 HLLSE--LKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDE 2215
HL +E K HSS S + M T + + +S +E R L W + + + E
Sbjct: 547 HLKAEPLTKATHSSSTSWFRKPM--TRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLE 604
Query: 2216 IEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLK----EL 2271
W N+ L + EL E + + +EEL S V + + ++
Sbjct: 605 RAEWGND---------------LPSVELQLETQQHIHTS---VEELGSSVKEARLYEGKM 646
Query: 2272 TKNLETPPDLQFIEADLMQKLEHAK-EITEVAKGTLKDFTAQSTQVEKFINDITT---WF 2327
++N T A+ + KLE ++ E + ++ + + KF++ T W
Sbjct: 647 SQNFHTS------YAETLGKLETQYCKLKETSSFRMRHLQS----LHKFVSRATAELIWL 696
Query: 2328 TKVEESLM--NCAQNETCEALKK--VKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2383
+ EE + + + N + + K+ ++ EL+ +Q S Q+ L + H A+ +
Sbjct: 697 NEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAK-Q 755
Query: 2384 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK-HFSESMQEFQEWFLGAKAAAKE--SS 2440
++ + + + + QLC + ++E+ F +E + + + + K S
Sbjct: 756 TVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSC 815
Query: 2441 DRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYA-------HLSKQIVSSIQ 2493
D LE L D + + + +S + ++ +T+ H+ K +S
Sbjct: 816 DHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTIS--- 872
Query: 2494 EQITKANEEFQAFLKQCLKDKQALQDCA--------SELGSFEDQHRKLNLWIHEMEERF 2545
+ + Q + C D+ L+D + S G+ L ++
Sbjct: 873 --VKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAI 930
Query: 2546 N-TENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRL 2604
+ +S Q + +++H L R+ LD L Q L G+ ++
Sbjct: 931 EMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLD-LVQTWNLEKLRSSAPGECHQI 989
Query: 2605 CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSK 2664
L +++ L+ +++ S ++ + LEE +++ KA L + +
Sbjct: 990 MKNLQAHYEDFLQDSRD---SVLFSVADRLRLEEEVEAC----KARFQHLMKSMENEDKE 1042
Query: 2665 DTLEKR-LSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723
+T+ K +S++++I L E E ++ I Q+L SS + ++ W D
Sbjct: 1043 ETVAKMYISELKNIRLRLEEYEQRVVKRI----QSLASSRTD------------RDAWQD 1086
Query: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHL 2783
+ T E + QL +++V K + L P L L
Sbjct: 1087 NALRIAEQEHTQEDL-----------QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSEL 1135
Query: 2784 QSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE 2843
++L E DH L + KT D + EL + +I E
Sbjct: 1136 -NLLVEKMDHVYGLSTVYLNKL----KTVDVIVRSIQDAELLVKGYEIKL-------SQE 1183
Query: 2844 EIVKDHLMYLDAVHEFTDWLHSAKEELHRW-SDMSGDSSATQKKLSKIKELIDSREIGAS 2902
E+V L L+A W L W SD+ +S S + E I ++ A
Sbjct: 1184 EVVLADLSALEA-----HW-----STLRHWLSDVKDKNSV----FSVLDEEIAKAKVVAE 1229
Query: 2903 RLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSE 2962
++SR L PE D +++++ Q Q +++Q+ + +
Sbjct: 1230 QMSR---LTPE-------------------RNLDLERYQEKGSQLQERWHRVIAQLEIRQ 1267
Query: 2963 QEFSGQVAQLEQALEQFSALLK----TWAQQLTLLEGKNTDEEIVECWHKGQEILDALQK 3018
E L L+K T AQQ + G+ D ++ Q L A
Sbjct: 1268 SELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFA--- 1324
Query: 3019 AEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNC--LCLQASKGCQNKEQILQQRF 3076
E +++L++ +FS+ ST ++K+Y + +A Q K ++R
Sbjct: 1325 ---EIERNQTKLDQCQKFSQQYST-------IVKDYELQLMTYKAFVESQQKSPGKRRRM 1374
Query: 3077 RKAFRDFQQWLVNAKIT-TAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3135
+ Q ++ + TA Q++ +S +L++++E E + K +
Sbjct: 1375 LSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEE--EEKVVEEEKQEHVEKVK 1432
Query: 3136 ELLSTLLTKEKAKGIQAKVTAAK-EDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQD 3194
ELL + T A+ Q K T+++ ++ + + +++ E L + + + + Q
Sbjct: 1433 ELLGWVSTL--ARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQI 1490
Query: 3195 WLSK--------TEKMVHESSNRL----YDL-PAKRREQQKLQSVLE---EIHCYEPQLN 3238
+L+K +K + E N L +DL + Q+LQS L E + Q N
Sbjct: 1491 FLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQN 1550
Query: 3239 RLKEKAQQL--WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGI 3296
++ + L W GQA H+ AL + D I F+ +
Sbjct: 1551 TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVV 1610
Query: 3297 KELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQ--EKEIQMKMIVTRGESV 3354
K+++ +M + L S T+ + L + EAL + +KE++ + +
Sbjct: 1611 KDIEGFMEENQTKL-SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669
Query: 3355 LQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDS 3414
++ + + + ++++ ++ D S+ S+G + + L G G G +D+
Sbjct: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGM-----EQLSGASLEKGALDT 1724
Query: 3415 MEANLNESERQHAELRDKTTMLGKAK---LLNEE---VLSYSSLLETIEVKGAGMT--EH 3466
+ + + Q E DK + KA+ LL+++ +L+ S ++ G +T E
Sbjct: 1725 TDGYMGVN--QAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQ 1782
Query: 3467 YVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY- 3525
+ Q +L +L+E+Y +++ + + + L Q++ +D K FE WL + +++L+
Sbjct: 1783 QMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMH 1842
Query: 3526 ----------SVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3575
S+L+ E + +L+ GQ +L+ +E PS I
Sbjct: 1843 KGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLV 1902
Query: 3576 DRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE--------- 3626
L+ + + A + + + N ++ + + + W++ E
Sbjct: 1903 KDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDT 1962
Query: 3627 ---------------KKWHEEVTAYRDEVEEVGARAQEIL--------DESHVNSRMGCQ 3663
K+ EE+ ++ VE++ A++I+ D HV
Sbjct: 1963 VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET---- 2018
Query: 3664 ATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV 3723
+ S +Q+L + E+ L++ I + + SL S G +N + ++ +
Sbjct: 2019 TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG--KQVSSL 2076
Query: 3724 DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLK 3783
+ ++ + L T L +D+ + S L++ RE R ++ + A L+ ++ + ++ +
Sbjct: 2077 SSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2136
Query: 3784 ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK 3843
+L +++ +L+K L A+ F L Q++ +L +P ++
Sbjct: 2137 QLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF------ 2190
Query: 3844 YKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIA 3903
++ +Q+ L E ++ +D L+ +L S G A+ ++
Sbjct: 2191 FQQIQELNLEMEDQ--------------------QENLDTLEHLVTELSSCGFAL--DLC 2228
Query: 3904 GFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
+DR+ NL+ LQ +K+ KD+ S C ++ L
Sbjct: 2229 QHQDRVQNLRKD--------FTELQKTVKER-------EKDASS--CQEQLDEFRKLVRT 2271
Query: 3964 LQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE----QARTYL 4019
QK WL + + P+ + +S E KQ++H ++L + +
Sbjct: 2272 FQK-------------WLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKGTLVE 2317
Query: 4020 DLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDAD 4079
++ C L N ++ TA D Q +I + + G+ K L +E+ + D
Sbjct: 2318 EINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-TEIQCDMSD-- 2374
Query: 4080 QQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKE 4139
+N+ + V L +Q S+ I+ ++ ++ HKE
Sbjct: 2375 --------------VNLKYEKLGGV------LHERQESLQAILNRMEEV--------HKE 2406
Query: 4140 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4199
N + QWL+ +E++ ++ D E ++ AES
Sbjct: 2407 ANSVL-QWLE-----------SKEEVLKSMDAMSSPTKTET------------VKAQAES 2442
Query: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4259
L L++ + +Q+ K A+ L ++ + N + E K+ L RW + +
Sbjct: 2443 NKAFLAELEQNSPKIQKVKEALAGL------LVTYPNSQEAENWKKIQEELNSRWERATE 2496
Query: 4260 LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAI 4319
+ + + + L Q+ +L W E++ + S P+M +
Sbjct: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFM 2556
Query: 4320 CSELEAKQMLLKSLIKDADRVMA---DLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKY 4376
E EA++ + L + A ++ D+ L+ QV ++ S Q V L+D + R
Sbjct: 2557 LKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE-LTDKLNSRSSQ 2615
Query: 4377 LNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ 4436
+++A+ + TQ+ + + +++ +++ + I P+ V +Q++ ++ L+
Sbjct: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLD 2675
Query: 4437 NEVTGLWAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4495
+EV EL + EQ K E+ +L+ + + + R+ L+ L S +
Sbjct: 2676 HEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQ 2735
Query: 4496 FKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTG 4555
F++ FD+ WL + + L +QL + + + ++ + G
Sbjct: 2736 FQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEG 2795
Query: 4556 QTILPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQ 4614
+++L S+ + L +L L + + D+ ++++ + ++Y +E
Sbjct: 2796 ESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVP 2855
Query: 4615 SLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQ 4674
+ + +A+ + + +E +L +A+L+EV ++ LN + ++ +
Sbjct: 2856 WIEDCKAKMSELRVTLDPVQLESSLLRS---KAMLNEVEKRRSLLEILNSAADILINSSE 2912
Query: 4675 PWQPDKMLHLVTLYHRLKRQTEQ---RVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE-- 4729
+ + + TE+ + LE+ T +E ++ + +E++++ K +
Sbjct: 2913 ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLE 2972
Query: 4730 -------QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4782
Q+ N+ EKL+ + +L+ L+ T L + AP D +
Sbjct: 2973 IFDALGSQACSNKNL----EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP--DGSDASQ 3026
Query: 4783 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL 4842
HQ + Q E + + E+++ F + L + EL G +
Sbjct: 3027 LLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAI 3086
Query: 4843 DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSEL 4902
+ +Q +I +++ ++ + A + + + L L+ L L++
Sbjct: 3087 GRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQ 3146
Query: 4903 DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESAEENL 4961
G + E + RQ L + + +Y+ + ND A+E L G +VE + L
Sbjct: 3147 CGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQL 3206
Query: 4962 KSHMEFFSTE-DQFHSNLEELHSLVATLDPLIKPTGKE----DLEQKVASLELRSQRMSR 5016
F + D L++++ L LI+ GK+ LE + + R +++
Sbjct: 3207 ADFKMFQKEQVDPLQMKLQQVNGLG---QGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263
Query: 5017 DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKA 5076
++ LQ +Q A E ++ + DTE+ ++ ++ + ++ E K
Sbjct: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN-QKPPSAEYKVVKAQIQEQKL 3322
Query: 5077 LVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILE 5136
L +++ + L+ + ++ ++ A + ++ + ++ RWT L + A ++K LE
Sbjct: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382
Query: 5137 DAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSA 5196
D + F+ + ++ + + KL S A++ + H ++E +
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442
Query: 5197 LGMLRQ--QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDR 5254
+ + Q+LS L +P E+ L ++I ++Q R +Q++ L+ Q L +
Sbjct: 3443 VHQAVKIGQSLSSLT-----SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNA 3497
Query: 5255 EMVETQINSVKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQNIE---K 5305
+ V W+ E ++ L + ++ + Q + L E N ++N++ K
Sbjct: 3498 RLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIK 3557
Query: 5306 MAEEQKEKYLGLYTILPSE----LSLQLAEVAL-DLKIRDQIQDKIKEVEQSKATSQELS 5360
+ ++ G +L E + + A++ + K ++ + + ++T +EL+
Sbjct: 3558 NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELT 3617
Query: 5361 RQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEE-------LDGCNSKLMELDAAVQ 5413
++++ ++L T + + + Q + QK L +E LD N E+ A+
Sbjct: 3618 GWLREVEEELATSGGQ-SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN----EVSRALL 3672
Query: 5414 KFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIE 5473
+ + + G L K + E ++ R+ +++ A ++Y + + L W+
Sbjct: 3673 ELVPWRAREG--LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVA 3730
Query: 5474 --KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSVY--C 5527
K K++A G I +L + Q ++++ ID ++M E + + ++ C
Sbjct: 3731 ETKRKLMALGPI------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTC 3784
Query: 5528 TEK----MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQAT 5583
E+ + ++ L ++ E + + R L+ A + +F ++L +E+ +A
Sbjct: 3785 GEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL 3844
Query: 5584 ---LTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA 5640
L SP + L++Q + L + KP + + L+ + +
Sbjct: 3845 IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM-VEEK 3903
Query: 5641 ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDKPVAT 5697
+ + ++++ Q+ + AV Q Q + +++ + + +E + P+
Sbjct: 3904 YQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIP 3963
Query: 5698 SNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGT 5757
+ + +++ IS ++ +++ Q +L + + L +++ A L E++ +
Sbjct: 3964 AEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQM 4023
Query: 5758 ----EDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSP 5813
ED+ V+ + + + + +T + ++ SP
Sbjct: 4024 VFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP-------- 4075
Query: 5814 VANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSATAKL 5866
++ I Q +AE ++ + +H + + G +P +
Sbjct: 4076 ------GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSI 4129
Query: 5867 GDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG---R 5923
++ +WE L E+ L +A++ +YQD+LQ++ ++ +KL P G
Sbjct: 4130 DEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLN 4189
Query: 5924 SPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 5983
+ + Q+ E + E+ Q E+ +L E ++ ++ D ++ ++ LT L
Sbjct: 4190 TVKDQLNEMKEFKVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTELKHLW 4246
Query: 5984 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6043
+ K + ++ LE L AL +++ +EL SWL T+ LD
Sbjct: 4247 ENLGEKIAHRQHKLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQRPISG 4296
Query: 6044 EPMDMEAQLMD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRR 6100
+P +E +L +N ++ + V +++ N LLE A D+A L +L
Sbjct: 4297 DPKVIEVELAKHHVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRSRLEA 4350
Query: 6101 LKGSLLELQRALHDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--WTQQR 6156
+ + + +++ +Q T Q+ + S+++ + ++ L+ ++ T +
Sbjct: 4351 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETA 4410
Query: 6157 QSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-----L 6211
+ L EL +L ++ + +G +L+ + + + +L Q+
Sbjct: 4411 REQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSS 4470
Query: 6212 GMEGEKSSAEDQMRM--KWESLHQEF--------------STKQKLLQNVLEQEQEQVLY 6255
ME KS E+ + + ++++ QEF S +L VL Q +E ++
Sbjct: 4471 KMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVF 4530
Query: 6256 SRP-----NRLL----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSGGAKR 6303
+ ++++ +G L K QD + +LL + +E+V S + G +
Sbjct: 4531 ANEVNAHRDQIIELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 4589
Query: 6304 QSIHLEQKLYDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKEMSEE 6361
+ ++ ++ WL+D E L + P++ + L + K +
Sbjct: 4590 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPV 4649
Query: 6362 MD---------KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6412
D K K L PE+ D LG + V + + + +L
Sbjct: 4650 YDTTIRTGRALKEKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVERQHKL 4698
Query: 6413 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD------ 6466
++ L F +L D Y + +LA +QPV ++ + D K F
Sbjct: 4699 EEALLFSGQFMDALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKELGKR 4756
Query: 6467 AGIIELKRRGDKLQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQY 6520
G +++ +R + +E +L +L +D + + S++S L Q L +
Sbjct: 4757 TGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF 4816
Query: 6521 ERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI--------- 6571
+ L + L ++ + + + E +Q L+D HKE+ + +E +
Sbjct: 4817 RDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMG 4875
Query: 6572 --------------------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+ F +++++A Q + + T L S ++ A
Sbjct: 4876 EVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAELLEE 4931
Query: 6612 ELEYILETWSH---LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLYQHLK 6665
L +I W+ + DQ+ + + ++ V++ I E R +DR+T K
Sbjct: 4932 LLAWI--QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRK 4989
Query: 6666 SSLNEYQPKLYQVLDDGKRLLIS--------ISCSDLES-QLNQLGECW-------LSNT 6709
+ + P + + G++ L +S S+ ++ ++NQL W L
Sbjct: 4990 NIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQ 5049
Query: 6710 NKMSKELHRLETILKHWTRYQSE--SADLIHWLQSAKDRL 6747
K++ L RLE LK + + + + W+ K R+
Sbjct: 5050 RKLNDALDRLEE-LKEFANFDFDVWRKKYMRWMNHKKSRV 5088
Score = 315 bits (806), Expect = 2e-84
Identities = 748/3948 (18%), Positives = 1528/3948 (38%), Gaps = 515/3948 (13%)
Query: 4436 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR-- 4493
+ EV A+ + LMK + ++K E + K+ Y S L+ RL+E E+ +V R
Sbjct: 1019 EEEVEACKARFQHLMKSMENEDKEETVAKM------YISELKNIRLRLEEYEQRVVKRIQ 1072
Query: 4494 --KHFKEDFDKACHWLKQADIVTFPEI---NLMNESSELHTQLAKYQNILEQSPEYENLL 4548
+ D D W A + E +L S+L K + L QSP ++
Sbjct: 1073 SLASSRTDRDA---WQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSV- 1128
Query: 4549 LTLQRTGQTILPSLN----EVDHSY--LSEKLNALPRQFNVIVALAKDKFYKVQEAILAR 4602
T+ LN ++DH Y + LN L + +VIV +Q+A L
Sbjct: 1129 -------PTLRSELNLLVEKMDHVYGLSTVYLNKL-KTVDVIVR-------SIQDAELLV 1173
Query: 4603 KEYA---SLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAV 4659
K Y S E+ LS LEA + + +D+ + ++ ++LDE + V
Sbjct: 1174 KGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVF------SVLDEEIAKAKVV 1227
Query: 4660 DELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
E + R+ +K L +HR+ Q E R S LE ++ L
Sbjct: 1228 AEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTL 1287
Query: 4720 ERQLKSVKEEQSKVN----EETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAP-- 4773
+ ++ +Q + E++ E+L +L ++ + L + + +
Sbjct: 1288 IKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIV 1347
Query: 4774 ---HLDPLAYEKARHQIQSWQGELKLLTS---AIGETVTECESRMVQSIDFQTEMSRSL- 4826
L + Y+ Q G+ + + S AI + + +R + T+ + +
Sbjct: 1348 KDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS 1407
Query: 4827 DWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKE 4886
D LRR++ E + + EE + Q H E+V+ L ++ L+ + K T ++
Sbjct: 1408 DALRRLEEE-----------EKVVEEEK--QEHVEKVKELLGWVSTLARNTQGKATSSET 1454
Query: 4887 LISADLEHSLAELSELDGD-------IQEALRTRQATLT---------EIYSQCQRYYQV 4930
S D+E ++ E L + + EA++T Q L E ++ +
Sbjct: 1455 KESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNAL 1514
Query: 4931 FQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDP 4990
+A +D + + LQ + L ++ ++ L+ ++ H LE+L S V +
Sbjct: 1515 NKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQ------QNTCHQQLEDLCSWVGQAER 1568
Query: 4991 LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTE 5050
+ +Q +++L+ ++Q +D Q D+ R T+ + +++ M + +
Sbjct: 1569 ALAGHQGRTTQQDLSALQ-KNQSDLKD--LQDDIQNRATS----FATVVKDIEGFMEENQ 1621
Query: 5051 KKLSEFSLL----KTSSSHEAEEKLSEH---------KALVSVVNSFHEKIVALEEKASQ 5097
KLS L K + E E L E +A+ S + EK A +E A
Sbjct: 1622 TKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAEN 1681
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
+K DA ++ ++ Q T L + Q LE + T V +A E +D
Sbjct: 1682 KKKI--DALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 1739
Query: 5158 QLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPG 5217
+ + + KA LL F+L + Q+ L Q G TP
Sbjct: 1740 KQCEMM---------KARHQELLSQQQNFILATQSAQAFLD----------QHGHNLTPE 1780
Query: 5218 EEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN 5277
E+ L Q++ G+L +Q E ++ V+ E +++L +
Sbjct: 1781 EQQMLQQKL-----------------GELKEQYSTSLAQSEAELKQVQTLQDELQKFLQD 1823
Query: 5278 PTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LAEVAL- 5334
+E + L + +N+ K + LPS L Q +E +
Sbjct: 1824 H--------KEFESWLERSEKELENMHKGGSSPET--------LPSLLKRQGSFSEDVIS 1867
Query: 5335 ---DLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQ 5391
DL+ K+ ++E S +E S +I L KD KLK T+ +
Sbjct: 1868 HKGDLRFVTISGQKVLDMENSFKEGKEPS-EIGNLVKD------KLKDATERYTALHSKC 1920
Query: 5392 KVLGEEL--------------DGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELH 5437
LG L D + + +A V+K L + ++ T+
Sbjct: 1921 TRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL 1980
Query: 5438 QQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA--KVLAHGTIAWNSAS-QLREQ 5494
Q+ + + + + KL + A + E + +++ +L+H + S S L E+
Sbjct: 1981 QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH----FQSLSYSLAER 2036
Query: 5495 YILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQ 5554
L Q + +S+ + LE++ + + + +QV+ L +++ + ++
Sbjct: 2037 SSLLQKAIAQSQSVQESLESLLQSIGEVEQ----NLEGKQVSSLSSGV--IQEALATNMK 2090
Query: 5555 NLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS-----LKEQLSHRQHLLSEME 5609
QD A+ EA + + +E A +T + G+L+ ++ +Q S ++
Sbjct: 2091 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2150
Query: 5610 SLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY 5669
L P+ + + L+ + E SR+ +
Sbjct: 2151 KLLPQAEMFEHLSGKLQ----------------QFMENKSRM--------------LASG 2180
Query: 5670 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS---------RHEELAQKI--- 5717
Q +Q++ H Q I+ + E+ED+ ++ L ++S +H++ Q +
Sbjct: 2181 NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKD 2240
Query: 5718 -----KGYQEQIASLNSKCKMLTMKAKHA-TMLLTVTEVEGLAEGTE-DLDGELLPTPSA 5770
K +E+ +S + L K T + E EG TE + + L
Sbjct: 2241 FTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIE 2300
Query: 5771 HPSVVMMTAGRCHTLLSPVT-EESGEEGTNSEISSPPAC-RSPSPVANTDASVNQDIAYY 5828
H ++ TL+ + + + E EI++P + ++ S + + +SV Y+
Sbjct: 2301 HLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH 2360
Query: 5829 QALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLY 5888
+Q D + D+ +E L V+ E+Q +L
Sbjct: 2361 TCKDLTEIQCD--------------------------MSDVNLKYEKLGGVLHERQESLQ 2394
Query: 5889 EALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGRSPESQMAEHQALMDEILMLQ 5943
L R ++ S+ +E+ E L SP + ++Q ++A + E+
Sbjct: 2395 AILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNS 2454
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
+I +++ +LA LV+ + +Q L ER + + +
Sbjct: 2455 PKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR----------- 2503
Query: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6063
QLEE A ++ +L WL+ + + +P + AQ Q ML E E
Sbjct: 2504 QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFE 2561
Query: 6064 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDK-----QLN 6118
+ +L+ + +L G Q+ +L+ + +EL L+ + Q
Sbjct: 2562 ARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAI 2620
Query: 6119 MQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQ---ELAE 6172
++ T ++ D+ Q VQ ++ QQ + + + + +LEQ E+ E
Sbjct: 2621 VKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKE 2680
Query: 6173 QKSLLRSVASR-GEEIL-------IQHSAAETSGD---AGEKPDVLSQELGMEGEKSSAE 6221
++L ++ GE+ L ++ A G A ++ + L L +
Sbjct: 2681 AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMF 2740
Query: 6222 DQMRMKWESLHQE------FSTKQKLLQNVLEQEQE------------QVLYSRPNRLLS 6263
D++R + + S K + LQ+ L++ +E +V+ + LL
Sbjct: 2741 DELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLL 2800
Query: 6264 GVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS-----IHLEQKLYDGVSA 6318
VP P ++K + + L L +EE+S ++ A RQS + QK V
Sbjct: 2801 SVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADRQSRLKDCMQKAQKYQWHVED 2852
Query: 6319 TSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENG 6377
W++D + ++ + L P + E+ L + + ++++ ++ + +
Sbjct: 2853 LVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSE 2912
Query: 6378 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII- 6436
+ D I D + + + + + ++E Q++ FQ K + + K+ +
Sbjct: 2913 ADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLE 2972
Query: 6437 ------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDAGIIELKRRGDK----LQVEQ 6483
Q +N + + Q E +Q E D L+ F G++E G L +
Sbjct: 2973 IFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAE 3032
Query: 6484 PSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQK 6543
+ QE +++ + +++ ++ G+ Q + L DL D L+ G + D
Sbjct: 3033 VAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELD-GMGAIGRDTD 3091
Query: 6544 IIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLFRKIISFAVQKETQFHTELMA 6597
+ S E+++ L+K +E+ HM+ E + +++E + L
Sbjct: 3092 SLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLL---GLKRELE---ALNK 3145
Query: 6598 QASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRL 6654
Q + +R R +LE L E + + + + E E+ VG E ++
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205
Query: 6655 IDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTN 6710
+ ++Q K ++ Q KL QV G+ L+ S LE + ++ W +
Sbjct: 3206 LADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNK 3263
Query: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNA 6770
K+++ + +L+ L H ++Q L+ WL ++ + S E ++V+ +
Sbjct: 3264 KVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA----EYKVVKAQIQE 3319
Query: 6771 FLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSELSRIDSQWTDLLTNIPAVQE 6829
+ +D + + + + G ++ + ++ D + +L ++S+WT+LL+ A Q+
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
Query: 6830 KLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKI 6887
+L + + + ++S+ E + E +G + I + + ++K +
Sbjct: 3380 QLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP-----VGTQTAKIQQQIIRHKALEE 3434
Query: 6888 DINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 6944
DI V + QS+ ++S + S+K D ++ + +Q K
Sbjct: 3435 DIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID------SLQARYSEIQDRCCRKAA 3488
Query: 6945 LLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAK 7003
LL+ L + + E+ V+ L E ++K + Q + D L + I +
Sbjct: 3489 LLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNR 3548
Query: 7004 EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSS 7063
+K V++ +NG AL++ + ++ L + +A++ + L+ +
Sbjct: 3549 KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608
Query: 7064 HKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKF 7119
+ ++++ +L E L+ +G Q+ Q Q +L+K+ L
Sbjct: 3609 FQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
Query: 7120 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 7179
++ LL+ E L + + N ++ + + I +++ A +Q Q+Y+ Q
Sbjct: 3665 NEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----Q 3720
Query: 7180 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 7239
A T L A + D+ +Q + KDS+ L ++
Sbjct: 3721 AADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
Query: 7240 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 7299
+ +Q SL Q A+ ++ L+ + F ++ E L WI E
Sbjct: 3781 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 3840
Query: 7300 AEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLP-LNDKE--- 7355
++ Q PS + D ++++ EE++ + P +D+L ++G +L LN +E
Sbjct: 3841 TRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM 3899
Query: 7356 -IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FLEKCETWMEFLVQTEQKLAVE 7411
++ Q ++ I + +R L + Q F +K E +E L +L +
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
Query: 7412 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLK 7465
I + E ++ E+ Q ++ G+ L+ + Q D+D E K
Sbjct: 3960 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4019
Query: 7466 LTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7521
L + W+ + RA++R +++ + W + ++ V L G+
Sbjct: 4020 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDP 4079
Query: 7522 VPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELA 7577
I Q A T+ +E +E F+R G+ L+ + + ++ +
Sbjct: 4080 SIIKQQVEAAETIKEETDGLHEELEFIRILGA---------DLIFACGETEKPEVRKSID 4130
Query: 7578 EIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADSLEK--------------LRT 7620
E+ W++ + +E+ +KL ++ ++ + + D L+ L T
Sbjct: 4131 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4190
Query: 7621 FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILN 7680
K +L++ + + E++ +Q+ ++L + +L L K T D I+
Sbjct: 4191 VKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GELMLKKAT-----DETDRDIIR 4236
Query: 7681 ERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQ----NG 7736
E + L+ WE L +++ R+ ++ L F +EL WLT E + +G
Sbjct: 4237 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG 4296
Query: 7737 DILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
D + E +E K + +A + ++ + + G L ++S AS + +L +N W
Sbjct: 4297 DPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4355
Query: 7796 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQR 7853
+ +L R ++L+ TL Q + L +ES+L+ KP E +
Sbjct: 4356 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT---GGLPETARE 4412
Query: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
+L+ EL ++ +L+ ++L D + ++ + Q+ L+++W +
Sbjct: 4413 QLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE---QSVALLEQKWHVVS 4469
Query: 7914 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
+ ER+ K+EE L +F + F +WL +E++ S +I ++++ +
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKV 4529
Query: 7974 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8033
F +V+ Q+ +++ +L ++ +K ++ RW+ + +R R L
Sbjct: 4530 FANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLD 4589
Query: 8034 HFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNK 8091
+ ++F A ++ WL + + L + +E ++ D ++ ++ + K FQ+ +
Sbjct: 4590 DARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPV 4649
Query: 8092 IEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFGR-VERYHK 8137
+ I G L EK+ P D+ ++ L E+R V G+ VER HK
Sbjct: 4650 YDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 4697
Score = 288 bits (737), Expect = 2e-76
Identities = 714/3992 (17%), Positives = 1540/3992 (38%), Gaps = 473/3992 (11%)
Query: 4846 LQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGD 4905
L D++++ + EE+ + + +S + T + L + ++L E
Sbjct: 1204 LSDVKDKNSVFSVLDEEIAKAKVVAEQMS-----RLTPERNLDLERYQEKGSQLQERWHR 1258
Query: 4906 IQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED--AQELLQLAGNGLDVESAEENLKS 4963
+ L RQ+ L I Y W+E+ AQ+ + G D E L
Sbjct: 1259 VIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQ 1318
Query: 4964 HMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5023
F+ ++ + L++ ++K D E ++ + + + + G +
Sbjct: 1319 QTALFAEIERNQTKLDQCQKFSQQYSTIVK-----DYELQLMTYKAFVESQQKSPGKRRR 1373
Query: 5024 LLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNS 5083
+L A ++ R L+ T + + S +A +L E + +V
Sbjct: 1374 MLSSSDAITQEFMDLRTRYTALVTLTTQHVKYIS--------DALRRLEEEEKVVEEEKQ 1425
Query: 5084 FH-EKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEW 5142
H EK+ L S L + N KAT S + + T + +Q+ + E+ +
Sbjct: 1426 EHVEKVKELLGWVSTLAR--NTQGKATSSETKES-----TDIEKAILEQQVLSEELTTKK 1478
Query: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLE--YHDTFVLELEQQQSALGML 5200
+ +K + + + KL S EK +E L L YHD Q Q L
Sbjct: 1479 EQVSEAIKTSQIFLAKHGHKL--SEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQL 1536
Query: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQ 5260
QT T ++ + +R L + G+ +Q+L + ++
Sbjct: 1537 AHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQ-----GRTTQQDLSALQKNQSD 1591
Query: 5261 INSVKCWVQETKEYLGNPTIEIDAQLEELQILLT--EATNHRQNIEKMAEEQKEKYLGLY 5318
+ ++ +Q +I+ +EE Q L+ E T R+ + + E+ Y
Sbjct: 1592 LKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQ--------Y 1643
Query: 5319 TILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLK 5378
L E ++A+ L+ + +Q +E E+SKA ++++ + K + +L +
Sbjct: 1644 EALQEET--RVAQKELEEAVTSALQ---QETEKSKA-----AKELAENKKKIDALLDWVT 1693
Query: 5379 AKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQ 5438
+ + Q T+ + E+L G + + LD ++ N Q + L K+ + HQ
Sbjct: 1694 SVGSSGGQLLTNLPGM-EQLSGASLEKGALDTT-DGYMGVN-QAPEKLDKQCEMMKARHQ 1750
Query: 5439 QTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILH 5498
+ + Q +N + A + L++ HG H
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQ-------------------HG----------------H 1775
Query: 5499 QTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQD 5558
EE + + +L + E QY TS+ +E +QV L E LQ
Sbjct: 1776 NLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE--------------LQK 1819
Query: 5559 AAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV--- 5615
+D K+FE+ L++ + LE +SPE LK Q S + ++S L+
Sbjct: 1820 FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISG 1879
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNI-MQAAVVQYEQYEQ 5674
Q V +++ + ++ L L+ E H+ + + + QY Q++
Sbjct: 1880 QKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQN 1939
Query: 5675 EMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCK 5732
LQ ++ +E S+ LQ Q++ ++L +++ +Q + L +
Sbjct: 1940 SADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR 1999
Query: 5733 MLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVMMTAGRCHTLLSPVTE 5791
+ E+EG E + +H S+ A R L + +
Sbjct: 2000 -------------DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQ 2046
Query: 5792 -ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
+S +E S + S + +S++ + + +L+ D A+ S A+
Sbjct: 2047 SQSVQESLESLLQSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEAT 2105
Query: 5851 QEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS 5903
+E +E S TA KL ++ + +E L EK+ +L + L + + ++
Sbjct: 2106 REMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEH---- 2161
Query: 5904 ISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE 5963
+S K++ S G P+ + + E+ + ++ E +L E LV+E
Sbjct: 2162 LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL-EHLVTELSS 2220
Query: 5964 ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADE 6023
A L +R+ +R + ++ ++E+ D Q Q L +R
Sbjct: 2221 CGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQEQ---LDEFRKLVRT 2271
Query: 6024 LDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQKVVALSELSVHN--- 6076
WL T+ ++ PP E ++E Q+ +++L + K + E++
Sbjct: 2272 FQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL 2326
Query: 6077 ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQGTAQEKEESDVDLTA 6135
ENL++E T +++ G + GS + H K L T + + SDV+L
Sbjct: 2327 ENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL----TEIQCDMSDVNLKY 2379
Query: 6136 TQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRSVASRGEEILIQHSA- 6193
+ GV +RQ SLQ +E+ E S+L+ + S+ EE+L A
Sbjct: 2380 EKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQWLESK-EEVLKSMDAM 2427
Query: 6194 -----AETSGDAGEKPDVLSQELGMEGEK-------------SSAEDQMRMKWESLHQEF 6235
ET E EL K + Q W+ + +E
Sbjct: 2428 SSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEEL 2487
Query: 6236 STKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVS 6295
+++ + V Q Q+ S + + +K + +L L+ +
Sbjct: 2488 NSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS-----ID 2542
Query: 6296 SQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI 6355
A++Q + K ++ L++ + + + T + + +
Sbjct: 2543 PNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKW 2602
Query: 6356 KEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLLDSVVNQRCHQMKERLQ 6413
E++++++ + QA ++ +++++D + +G+ + S ++ + +K++L+
Sbjct: 2603 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLE 2662
Query: 6414 QILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----EAIQQAEDGLKEFDAGI 6469
+ ++DL+ L + + + + + + EQ + +++ E + GL++ A
Sbjct: 2663 ETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA-- 2720
Query: 6470 IELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6529
D++ Q ++ + Q M+DEL + ++S +N + ++ ER L +
Sbjct: 2721 -------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQE 2773
Query: 6530 LLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQK 6587
E + + +G ++IV+ E + + +E TL +++
Sbjct: 2774 NEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE-----------KRTLQNQLV------ 2816
Query: 6588 ETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLV 6647
E + H E +++ +A + S L + Q+ + VE +P +
Sbjct: 2817 ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQKYQWHVEDLVPWIEDC 2860
Query: 6648 EENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGKRLLISISCSD---LES 6696
+ L +D + L L K+ LNE + + L ++L+ +LI+ S +D +
Sbjct: 2861 KAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRD 2920
Query: 6697 QLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ--QS 6754
+ + + + T ++ + LE + + +Q ++ ++ AK +LE +
Sbjct: 2921 EKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ 2980
Query: 6755 VTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STGNQLLRLKKVDTATLRS 6808
+ LE +R +VD + ++ S +QLL +V
Sbjct: 2981 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLE 3040
Query: 6809 ELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENV--IQKDEDNI 6866
R++S ++ KL + R S++ ++ + I +D D++
Sbjct: 3041 VKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSL 3093
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
++ I + + +L K K+DI + + + E D +L
Sbjct: 3094 QSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE----------EEGTLDLLGLKRELE 3141
Query: 6927 AMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASV 6986
A+NK L + + LE L ++ ++ L E+ Q +G + +
Sbjct: 3142 ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEI 3201
Query: 6987 QNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKEDVSSIVMS-TLRELGQ 7038
N Q L D ++++V+ ++ NGL LIQ+ +D + + E+
Sbjct: 3202 IN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINA 3256
Query: 7039 TWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQ 7098
W L+ V Q L+ L + A + + S+L + ++ + + + V+ Q
Sbjct: 3257 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQ 3316
Query: 7099 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7158
+ + LQ L+ ++ ++ + ++ + E +T L+ + RW LL + A
Sbjct: 3317 IQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAA 3376
Query: 7159 QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDL 7218
+ + + +L L +++ + ++ + + E + T ++ D+
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
Query: 7219 LKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQA 7278
V ++ ++G+ L + + SL ++ C++ L
Sbjct: 3437 ENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQ 3492
Query: 7279 GVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--SDLSTIQERMEELKGQM 7329
+ + F + + W+ E E+ L QD H +D + E + K +
Sbjct: 3493 ALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNV 3552
Query: 7330 LKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT 7389
+ L + G + L +++ ++ ++ SS+ + + + Q+
Sbjct: 3553 DQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQS 3611
Query: 7390 FLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHELFQAEMFSRQQILHSII 7444
E+ W+ + E++LA SG EQ QR EL + E+ + +L ++
Sbjct: 3612 TYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL-KKEVMEHRLVLDTVN 3665
Query: 7445 IDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKL 7504
+ LLE R+ + ++ + Q++ V QR ID+ I++ Q+Y + A+
Sbjct: 3666 EVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAE 3725
Query: 7505 RKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQGSYILTVEAGKQLLL 7562
W+ E M+ LG PI L+Q +T +VQ + +R + S ++
Sbjct: 3726 LAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFG 3782
Query: 7563 SADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLKDWEKCEKGIADSLEKL 7618
+ + LQ + + +++++ S+ E+ +L + + WE E+ ++ +E+
Sbjct: 3783 TCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEE-LSPWIEET 3841
Query: 7619 RTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISI 7678
R +L DH E+L +Q ++L ++ + +L + L ++ ++ +
Sbjct: 3842 RALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNPEEGEM 3899
Query: 7679 LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNKELCEWLTQMESKVSQN 7735
+ E+ + + + ++ ++ R + E +++ F +K + + E L + S++
Sbjct: 3900 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 3959
Query: 7736 GDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLAKASH----ESKASEIE 7785
LI ++K+++ + + A + K+Q L++ GE L S + A EI+
Sbjct: 3960 P--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQ 4017
Query: 7786 YKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDS 7845
KL ++ W+ + R K + L ++ +M++L T + + IV+D
Sbjct: 4018 DKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQD-----IVHDL 4072
Query: 7846 CNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNL 7905
+ + +Q E I++ + G+ L +L D + E ++++ +
Sbjct: 4073 ESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEM 4132
Query: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAK 7965
+ W N+ ER K+E+ + ++ D DWL ++ G K
Sbjct: 4133 NNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVK 4192
Query: 7966 EELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLKQMVHEGNQRWDNLQK 8023
++L + + F+ +V++ ++E +N Q + ++ + TD +++ + E W+NL +
Sbjct: 4193 DQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IREPLTELKHLWENLGE 4251
Query: 8024 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD---VQAKIKQLKA 8080
++ +L+ + +F+ A + ++ WLT + +L + + D ++ ++ +
Sbjct: 4252 KIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPISGDPKVIEVELAKHHV 4310
Query: 8081 FQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKL- 8139
+ ++ + +E + G +L+E S DA+ + L+ + + + V + E ++L
Sbjct: 4311 LKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ 4370
Query: 8140 --------IRLPLPDDEHDLSDRELELEDS--------AALSDLHWHDRSADSLLSPQPS 8183
+ D +L+ E +L S A L H L + + +
Sbjct: 4371 STLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEET 4430
Query: 8184 SNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG 8239
N L + + R SG T SV + +W + +S + AL E
Sbjct: 4431 YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQ 4490
Query: 8240 QDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAI---KNTSGDHSALESQIRQLGKALDD 8296
++F + + I P + + I K + + +A QI +L + +
Sbjct: 4491 NSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQ 4550
Query: 8297 SRFQIQQT----------------ENIIRSKTPTGPELDTS-------YKGYMKLLG--- 8330
+F Q+ E +++ G LD + ++ + KL+
Sbjct: 4551 LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLE 4610
Query: 8331 ----------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVI---------- 8370
E S+ D +K K KE +++L G ++ T +T +
Sbjct: 4611 DAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS 4670
Query: 8371 -----------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQ 8419
D+W+ + +++ ++ ++++ L QF L ++ WL E +L + Q
Sbjct: 4671 QKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQ 4730
Query: 8420 RLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQM 8479
+ D+ + + K QK + R + + E + ++ ++ +L ++
Sbjct: 4731 --PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQEL 4788
Query: 8480 NGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDA 8537
+ RWD VC L + L+ AL Q + F + H LL L ++ R +P D+
Sbjct: 4789 STRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEA-L 4847
Query: 8538 EILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEA-KEKVHVIGNRLKL 8596
+ L D HK+ M+ ++ E ++ V S M ++++ DC+ K + +I R +
Sbjct: 4848 QSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCITTIKHWITIIRARFEE 4903
Query: 8597 LLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8624
+L +H + LE L V++++ ++L +W
Sbjct: 4904 VLTWAKQHQQRLETALSELVANAELLEELLAW 4935
Score = 275 bits (702), Expect = 2e-72
Identities = 788/4143 (19%), Positives = 1625/4143 (39%), Gaps = 506/4143 (12%)
Query: 4680 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLP 4739
+M HL +L+ + R T + + L E +E E++ ++ +++ +E T+
Sbjct: 675 RMRHLQSLHKFVSRATAELIWLNE------KEEEELAYDWSDNNSNISAKRNYFSELTME 728
Query: 4740 AEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTS 4799
EEK ++ SL QD T L L H E +QS +K L
Sbjct: 729 LEEKQDVFRSL----QD--------TAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCL 776
Query: 4800 AIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLN--LQDIQEEIRKIQ 4857
+ + V E + F ++ +LR ++ + D N L +++ ++
Sbjct: 777 CVEQHVKENTAYF----QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSM 832
Query: 4858 IHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELD-GDIQEALRTRQAT 4916
+E++ S + +L + K L+++++ + D I+ +
Sbjct: 833 DEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDEC 892
Query: 4917 LTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHS 4976
+ E SQ ++ + N+ + + L N +E A +S+ + + Q H
Sbjct: 893 VLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHV 952
Query: 4977 NLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDY- 5035
N + L S L DL Q +LRS G +++ A + D+
Sbjct: 953 NTKSLISWNYLRKDL-------DLVQTWNLEKLRSSA----PGECHQIMKNLQAHYEDFL 1001
Query: 5036 QKAREEVIELMNDTEKKLSEFSLLKTSSSH---EAEEKLSEHKALVSVVNSFHEKIVALE 5092
Q +R+ V+ + D + E K H E + E ++ + LE
Sbjct: 1002 QDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLE 1061
Query: 5093 EKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKA 5152
E ++ K + SR+ WQ LR Q+ + ++ + +
Sbjct: 1062 EYEQRVVKRIQSLAS---SRTDRDAWQD-NALRIAEQEHTQ------EDLQQLRSDLDAV 1111
Query: 5153 TEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML---- 5208
+ D + P SS+ ++EL L+E D V L S + + + +T+ ++
Sbjct: 1112 SMKCDSFLHQSPSSSSVPTLRSELNLLVEKMD-HVYGL----STVYLNKLKTVDVIVRSI 1166
Query: 5209 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5268
QD G E L QE + D L+ E + + ++KD+ V + ++
Sbjct: 1167 QDAELLVKGYEIKLSQEEVVLAD--LSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKA 1224
Query: 5269 QETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE------EQKEKYLGLYTILP 5322
+ E + T E + LE Q ++ + E E ++ LG Y
Sbjct: 1225 KVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACH 1284
Query: 5323 SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI----------------QKL 5366
L + E ++ K + E S+ S++LS+Q QK
Sbjct: 1285 GTLIKWIEETTAQQEMM-----KPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKF 1339
Query: 5367 AKDLTTILT--KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5424
++ +TI+ +L+ T ++ QK G+ L DA Q+F++
Sbjct: 1340 SQQYSTIVKDYELQLMTYKAF-VESQQKSPGKR----RRMLSSSDAITQEFMD------- 1387
Query: 5425 PLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEE----YNEMLELILKWIEKAKVLAH 5480
L + L L Q ++ + L +L + +EE + E ++ +L W+ LA
Sbjct: 1388 -LRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVS---TLAR 1443
Query: 5481 GTIAWNSASQLREQYILHQTLLEE---SKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAE 5537
T ++S+ +E + + +LE+ S+E+ ++ E ++E ++ TS K +++E
Sbjct: 1444 NTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIK--TSQIFLAKHGHKLSE 1501
Query: 5538 LGRE--TEELRQMIKIRLQNLQDAAKDMKKFEAEL--KKLQAALEQAQATLTSPEVGRLS 5593
++ +E+L + K +A +++ +++L + Q L++ Q T S
Sbjct: 1502 KEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCS 1561
Query: 5594 LKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQH 5653
Q + R + + + + A+Q QS L+ +D + + A + E ++
Sbjct: 1562 WVGQ-AERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN 1620
Query: 5654 TAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEEL 5713
+ A + Q +++ + LQ+ A +E+E+ TS +Q+ + +EL
Sbjct: 1621 QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEE--AVTSALQQETEKSKAAKEL 1678
Query: 5714 AQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPS 5773
A+ K +++ +T LLT G E L G L + +
Sbjct: 1679 AENKK-------KIDALLDWVTSVGSSGGQLLTNLP------GMEQLSGASLEKGALDTT 1725
Query: 5774 VVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5833
G G N ++P + D A +Q L +
Sbjct: 1726 -------------------DGYMGVN---------QAPEKL---DKQCEMMKARHQELLS 1754
Query: 5834 ERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5886
++ A T ++Q F + P + KLG+L+ + T + +
Sbjct: 1755 QQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQ 1809
Query: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILMLQ 5943
+ + QK+ + + +E E +L + G SPE S + + ++++ +
Sbjct: 1810 VQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRMKASGKRQLLEE 5999
++ + S + L E+ + E + + L ER + + K + L
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTR----LGS 1925
Query: 6000 KLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQN 6057
LN L + Q ++ AD L +W+ + +A ++ LS +P ++ QL +
Sbjct: 1926 HLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQ 1979
Query: 6058 MLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRRLKGSLLELQRA 6111
+ E+ + V + +L V + + +EG+ H ++ + + + L SL E + +
Sbjct: 1980 LQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAE-RSS 2038
Query: 6112 LHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---QSSLQQQKELEQ 6168
L K + + QE ES QS G E + + + Q +L +L+Q
Sbjct: 2039 LLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQ 2093
Query: 6169 ELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
++A QKS L R + +R E +AA G E Q + EK S+ ++
Sbjct: 2094 DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLL 2153
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLD 6285
+ E + + S K LQ +E + L G+ P QD + +
Sbjct: 2154 PQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPDQDITHFFQQIQ 2195
Query: 6286 GLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCL 6345
LN E+ +++++ + L +S+ LD + + V L + TE
Sbjct: 2196 ELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN-LRKDFTELQK 2246
Query: 6346 FNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRC 6405
+E KD E++D+ + L + +++T G S+ + +
Sbjct: 2247 TVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------SIPPTETSMSA 2292
Query: 6406 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEF 6465
+++++++ + + +D T + + + E + E Q + G
Sbjct: 2293 KELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAPDSQGKTGSILP 2347
Query: 6466 DAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERAL 6524
G G + +Q ++S + Y++L ++ R+ L L + +
Sbjct: 2348 SVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEA 2407
Query: 6525 QDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH----MILTETLFRK 6579
+ LE+ +E + + +K E ++ + +K + LE + + E L
Sbjct: 2408 NSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL 2467
Query: 6580 IISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---DEDQQELSRQLE 6635
++++ +E + ++ + ++ +RA + V + LE + SHL + +L L
Sbjct: 2468 LVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLM 2527
Query: 6636 VVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLL-----ISIS 6690
E + +G + + + L + Q + + + Q+ + + +L +S+S
Sbjct: 2528 EKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 2587
Query: 6691 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6750
S ++ +L + + W+ T+K++ +++ + T+YQ DL +++ RL
Sbjct: 2588 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 2647
Query: 6751 TQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQLLR---LKKVDT 6803
+ Q V Q+LE + + + EV +AQ+ + G Q L+ K+++T
Sbjct: 2648 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 2707
Query: 6804 ATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDE 6863
L L ++ D + + A Q Q E+ +W+ ++ K
Sbjct: 2708 VAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWLDDKQSQQAK-- 2756
Query: 6864 DNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQDVESKRSDKTD 6920
N S + + LQ+ + F+ +N + + + +S+L +S E KR+
Sbjct: 2757 -NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVPPGEEKRT---- 2810
Query: 6921 FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRI 6980
QL + W+ L ++ L+ ++ +Y+ +V+ L W E + ++ +
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVT 2870
Query: 6981 GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI----------VM 7030
D ++++L + + + ++ + +E + LI + + D I +
Sbjct: 2871 LDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMD 2930
Query: 7031 STLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINSYLMEARYSLSR 7084
+ EL +L+ M +L+ +S + + + H++ FD + S + +L +
Sbjct: 2931 AVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK-NLEK 2989
Query: 7085 FRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKE 7144
R L+A++ QVD L+N L + GS +QLL + E L E
Sbjct: 2990 LRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQEFL-----E 3040
Query: 7145 VNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQCASTVQQQEDR 7190
V R N+ ++E E + Q + +++ + D + S Q ED
Sbjct: 3041 VKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDV 3100
Query: 7191 TNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
L K K DI E +C +L+ GT+ D L EL KQ +
Sbjct: 3101 RLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEALNKQCGKLTERG 3154
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE-EILQGQD 7308
+ +QL L+ L +E K + G+ D T A+ EAL+ W+V E EI+ Q
Sbjct: 3155 KARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVVGTEVEIINQQ- 3205
Query: 7309 PSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWS 7367
+D Q E+++ L+ ++ + + + L + G + E M+ +N W+
Sbjct: 3206 ---LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE-HDMEEINARWN 3259
Query: 7368 LISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRA 7425
++ + +R ++LQ LL F + E + +L TE+ +A + S Y+ + Q +
Sbjct: 3260 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQE 3319
Query: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7485
+L Q + R+ + + +G R+ + ++ DR++ +L L ++W ++ +A R+
Sbjct: 3320 QKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
Query: 7486 IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVF 7543
++ + +++ E AE + +L S S P+ Q A+ ++ K E+
Sbjct: 3380 QLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDI 3436
Query: 7544 LRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWKSASMRLEEQKK 7595
V+ G Q L S S AE +LQA +EIQ++ + L++
Sbjct: 3437 ENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495
Query: 7596 KLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAEQM-RCKELENA 7649
+D + +A+ +KL + FK+ + H L+ E + R K ++ A
Sbjct: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQA 3555
Query: 7650 VGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLN 7709
+ + +LLK T + +++ ++ E+++ ++ ++ ++ S + + +
Sbjct: 3556 IKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQ 3604
Query: 7710 EWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAIAQENKIQLQQM 7768
F +EL WL ++E +++ +G E I + ++ +E E+++ L +
Sbjct: 3605 LATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTV 3664
Query: 7769 GERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7824
E +++A E +A E ++ + N++++ + D I RV ++ + QQ ++
Sbjct: 3665 NE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAAD 3723
Query: 7825 SLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVL 7882
+ W+A + +L PI + ++ +L Q+ DI +H + + + +
Sbjct: 3724 AELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 3780
Query: 7883 LHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFED 7942
C + + +Q+ T +L +++ I ++ ER ++E L +F + Y
Sbjct: 3781 FGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
Query: 7943 WLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTD 8002
W++ + A S + + +++ ++ + + E ++ + K +L N +
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE 3896
Query: 8003 SACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARDSILVWLTEMD- 8057
+MV E Q+ +N+ ++ +R+ L + Q + D I L ++
Sbjct: 3897 G-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLEN 3951
Query: 8058 ---------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEP 8108
L ++ EC I K+ E+ E + +GE+LI +S+
Sbjct: 3952 LSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKRRGEELIGRSQG 4006
Query: 8109 LD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAAL 8164
D A I+++LD++ + +++ R E +RE++ D L
Sbjct: 4007 ADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------EREIKFLDVLEL 4047
Query: 8165 SDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDL 8224
++ W+D +A L + + + ++ L P + + ++I E D L +L
Sbjct: 4048 AEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETD---GLHEEL 4103
Query: 8225 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALE 8284
E G+ +K + I E A+ EN K LE
Sbjct: 4104 EFIRILGADLIFACGETEKPEVRKS--------IDEMNNAW----ENLNKTWKERLEKLE 4151
Query: 8285 SQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEH 8344
++ + D + +N + K T P + T L E V+ +
Sbjct: 4152 DAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPPVGTDLNTVKDQLNEMKEF--KVEVYQQ 4208
Query: 8345 KLKEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKELRMKQNLQKWQ 8395
+++ E+ + G + L +T I R WE L + ++ +++ L
Sbjct: 4209 QIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALG 4268
Query: 8396 QFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSIN 8455
QF L + +WL TEE L+ + +S D + IE+++ K L+ V +A + ++N
Sbjct: 4269 QFQHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDVLAHQATVETVN 4326
Query: 8456 LCSPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGL 8514
E ++ + ++ L+ RL MN W+ V EE LQ L Q QGFH
Sbjct: 4327 KAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDF 4386
Query: 8515 LLMLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELLESQLRVASLQD 8566
LL L ++ + + P E L H + Q+K ++LL+ + +D
Sbjct: 4387 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRD 4446
Query: 8567 MSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSS 8626
S + LE +K HV+ ++++ + S+ + L + +S Q+ +W +
Sbjct: 4447 DSGSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQNSLQEFINWLT 4501
Query: 8627 ADE 8629
E
Sbjct: 4502 LAE 4504
Score = 274 bits (701), Expect = 2e-72
Identities = 855/4629 (18%), Positives = 1784/4629 (38%), Gaps = 694/4629 (14%)
Query: 3691 SLEESESSLSSYSDWYGSTHKNFK-NVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLL 3749
S+EE SS+ + G +NF + A + K++T K +T ++ ++ H +
Sbjct: 628 SVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLK-ETSSFRMRHLQSLHKFV 686
Query: 3750 KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDK 3809
A + + +L E E E L + D+ + + + M LE+ + + D
Sbjct: 687 SRATAE----LIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT 742
Query: 3810 CKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3869
AE + + P + +E Y Q S+ + ++Q L E VK + A
Sbjct: 743 --------AELLSLENHPAKQTVEAYSAAVQ-SQLQWMKQLCLCVEQHVK----ENTAYF 789
Query: 3870 ELVQDV--------TLKDKIDQLQS-DYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLI 3920
+ D L+D I + S D+ S + ++++ +++L + +L+
Sbjct: 790 QFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLV 849
Query: 3921 GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVS--RQDTLQQC- 3977
G+ +Q LK H+ S A+C Y+ +E + K+ +D Q+
Sbjct: 850 GRSKTIVQ--LKPRSPDHVLKNTISVKAVCD-----YRQIEITICKNDECVLEDNSQRTK 902
Query: 3978 ---------QAWLSAVQPDLEPSPQPPLSRAEAIKQ-VKHFRALQEQARTYLDLLCSMCD 4027
+A + +V + P + + A ++Q + AL Q L S
Sbjct: 903 WKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNY 962
Query: 4028 LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA--------- 4078
L KD+ QT + +++ + + +K+L++ +LQD+
Sbjct: 963 LR--------KDLDLV-QTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVA 1013
Query: 4079 -----DQQLQNMKRRHSEL---------ELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK 4124
+++++ K R L E +A+ +S++K+ +L+ + V +++
Sbjct: 1014 DRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRV---VKR 1070
Query: 4125 VNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEK 4184
+ L + + N L + Q + +EDLQ+ R D V + +
Sbjct: 1071 IQSLASSRTDRDAWQDNALR-----IAEQEHT-----QEDLQQLRSDLDA---VSMKCDS 1117
Query: 4185 FTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHL--NLDDKEL 4242
F L +S + S+ L + L + + Y + + K K ++ + ++ D EL
Sbjct: 1118 F------LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAEL 1171
Query: 4243 -VKEQTSHLEQRWFQLEDLIKRKIQVS-----VTNLEELNVVQSRFQELMEWAEEQQPNI 4296
VK L Q L DL + S ++++++ N V S E + A+ +
Sbjct: 1172 LVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKV----V 1227
Query: 4297 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQV--IQK 4354
AE + + P +NL +LE Q L + RV+A L + + ++ IQ+
Sbjct: 1228 AEQMSRLTPE---RNL---------DLERYQEKGSQLQERWHRVIAQLEIRQSELESIQE 1275
Query: 4355 ALSDAQSH----VNCLSDLVGQRR----------KYLNKALSEKTQFLMAVFQATSQIQQ 4400
L D ++ + + + Q+ + L++ LS++T + + +++ Q
Sbjct: 1276 VLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQ 1335
Query: 4401 HERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSE 4460
++ F + + D Q+ T K+ S + + + + + +E +
Sbjct: 1336 CQK---FSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRY 1392
Query: 4461 VLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH-FKEDFDKACHWLKQADIVTFPEIN 4519
L L + + + RL+E EK + K E + W+ T +
Sbjct: 1393 TA--LVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKAT 1450
Query: 4520 LMN--ESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS----LNEVDHSYLSEK 4573
ES+++ + + Q + E+ + + +T Q L L+E + +SE+
Sbjct: 1451 SSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQ 1510
Query: 4574 LNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDL 4633
LNAL + ++ + + ++ ++Q + + E +L + +LE + + L
Sbjct: 1511 LNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERAL 1570
Query: 4634 AVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----------EGFRSTGQPWQPDKMLH 4683
A + + Q A+ + L + D++ + EGF Q +
Sbjct: 1571 AGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPR--E 1628
Query: 4684 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEK 4743
L L +L + EQ +L E+T A +E E+ +Q + E+SK +E ++K
Sbjct: 1629 LTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQ----ETEKSKAAKELAENKKK 1684
Query: 4744 L---------------KMYHSLAGSLQDSGIVLKRVTIHLED------LAPHLDPLAYE- 4781
+ ++ +L G Q SG L++ + D AP E
Sbjct: 1685 IDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEM 1744
Query: 4782 -KARHQ-IQSWQGELKLLTSAI-------GETVTECESRMVQSI--DFQTEMSRSLDWLR 4830
KARHQ + S Q L T + G +T E +M+Q + + + S SL
Sbjct: 1745 MKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL---A 1801
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMN------------------- 4871
+ +AEL L LQ ++ ++ + E + L M+
Sbjct: 1802 QSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSF 1861
Query: 4872 ---ALSHKEKEKFTKAKELISADLEHSLAE---LSELDGDIQEALRTRQATLTEIYSQCQ 4925
+SHK +F D+E+S E SE+ +++ L+ T ++S+C
Sbjct: 1862 SEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCT 1921
Query: 4926 RY----------YQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFH 4975
R Y FQ + D L+ + + L ++ + E +T Q
Sbjct: 1922 RLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQ 1981
Query: 4976 SNLEELHSLVATLDPLIKPTGKED---------LEQKVASLELRSQRMSRDSGAQVDLLQ 5026
L E V L + + + + +++ S+ Q +S + LLQ
Sbjct: 1982 EELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQ 2041
Query: 5027 RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHE 5086
+ AQ Q++ E +++ + + E+ L E + + SS +E L+ + L +
Sbjct: 2042 KAIAQSQSVQESLESLLQSIGEVEQNL-EGKQVSSLSSGVIQEALATNMKLKQDIARQKS 2100
Query: 5087 KIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFN 5146
+ A E ++ +T + + A L + V QR+ +L Q++E L+ + + F
Sbjct: 2101 SLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE 2160
Query: 5147 NKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLS 5206
+ K + ++ L + ++ + LE+E QQ L L
Sbjct: 2161 HLSGKLQQFMENKSRMLASGNQPDQ---DITHFFQQIQELNLEMEDQQENLDTLEHLVTE 2217
Query: 5207 MLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKC 5266
+ G A ++ QDR N+++ K VK+ KD + Q++ +
Sbjct: 2218 LSSCGFA----------LDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRK 2267
Query: 5267 -------WVQETKEYLGNPTI------EIDAQLEELQILLTE--------------ATNH 5299
W++ET+ + PT E++ Q+E L+ LL + T+
Sbjct: 2268 LVRTFQKWLKETEGSIP-PTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSL 2326
Query: 5300 RQNIEKMAEEQKEKYLGLYTILPSELSL-----------QLAEVALDLKIRDQIQDKIKE 5348
I ++ + G +ILPS S L E+ D+ + +K+
Sbjct: 2327 ENLIMEITAPDSQGKTG--SILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGG 2384
Query: 5349 VEQSKATS-QELSRQIQKLAKDLTTILTKLKAK---------------TDNVVQAKTDQK 5392
V + S Q + +++++ K+ ++L L++K T+ V K
Sbjct: 2385 VLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNK 2444
Query: 5393 VLGEELDGCNSKLMELDAAVQKFLEQ--NGQLGKPLAKKIGKLTELHQQTIRQAENRLSK 5450
EL+ + K+ ++ A+ L N Q + K +L ++ R +
Sbjct: 2445 AFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQ 2504
Query: 5451 LNQAASHLEEYNEMLELILKWIEKAK----VLAHGTIAWNSASQLREQYILHQTLLEESK 5506
L ++ASHL + + W+ + + VL +I N + ++Q Q +L+E +
Sbjct: 2505 LEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQV---QFMLKEFE 2561
Query: 5507 EIDSELEAMTEKLQYLTS-----VYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAK 5561
+ E + E Q + + T ++ +++ + ++ EL + R + A
Sbjct: 2562 ARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIV 2621
Query: 5562 DMKKFEAELKKLQAA-------LEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPK 5614
+++ L+ L L A T PE ++K+QL + S++E L +
Sbjct: 2622 KSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPE----AVKQQLEETSEIRSDLEQLDHE 2677
Query: 5615 VQAVQ-LCQS-ALRIPEDVVASLPLCHAALRLQEEASRLQ---HTAIQQCNIMQAAVVQY 5669
V+ Q LC ++ I E + RL+ A LQ A + N +QAA+
Sbjct: 2678 VKEAQTLCDELSVLIGEQYLKD----ELKKRLETVALPLQGLEDLAADRINRLQAALAST 2733
Query: 5670 EQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNS 5729
+Q++Q L+ ++ + ++ ++ LQ+Q+ +EE +Q+ + +
Sbjct: 2734 QQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEE-------FQKSLNQHSG 2786
Query: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL---- 5785
+++ A+ ++LL+V E L +L+ + + TA R L
Sbjct: 2787 SYEVIV--AEGESLLLSVPP----GEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCM 2840
Query: 5786 ------------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSA 5833
L P E+ + + ++ P + S + + A +N+ + S
Sbjct: 2841 QKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPV-QLESSLLRSKAMLNE---VEKRRSL 2896
Query: 5834 ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALER 5893
+ AA I ++S E E G+ + ++ + + + K +L E +R
Sbjct: 2897 LEILNSAADILINSS---EADEDGIRDEKAG----INQNMDAVTEELQAKTGSLEEMTQR 2949
Query: 5894 QQKYQDSLQSISTKMEAI--ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQS 5951
+++Q+S ++I K+E +L++ ++ + + +A + + L+ +++ L+
Sbjct: 2950 LREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLR- 3008
Query: 5952 SLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQE 6011
+ + LV ++ + A QL Q+ V + ++ + + ++E KL
Sbjct: 3009 NFTQGLVEDAPDGSDASQLLHQA--EVAQQEFLEVKQRVNSGCVMMENKL---------- 3056
Query: 6012 QALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNML-------VEIEQ 6064
+ + ++ C E+ S L LD + ++ +++Q+ D + L ++IE
Sbjct: 3057 EGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3116
Query: 6065 KVVALSELSVHNENLLLEGKAHTKDEAEQLAGKL-RRLKGSLLELQRALHD--------K 6115
+ L L G + + GKL R K +L+ L K
Sbjct: 3117 SEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK 3176
Query: 6116 QLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQ---RQSSLQQ---------- 6162
LN TA E+ E+ + T+ + + LA + +Q Q LQQ
Sbjct: 3177 GLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ 3236
Query: 6163 -----------QKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQEL 6211
+ ++E+ A +L + VA R ++ E G+ D L L
Sbjct: 3237 SAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQL------QEALLHCGKFQDALEPLL 3290
Query: 6212 G--MEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV--LYSRPNRLLSGVPL 6267
+ E+ A + + + +QKLLQ +L+ + V L + R+ L
Sbjct: 3291 SWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL 3350
Query: 6268 YKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLD 6324
D+ +T L+ L + E+ S++ ++Q + L ++ ++ S +L
Sbjct: 3351 -------ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLS 3403
Query: 6325 DVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFP--------EN 6376
E++L + P T+T Q+I+ K + E+++ + QA +
Sbjct: 3404 VTEKKLANSE---PVGTQTAKIQQQIIRH--KALEEDIENHATDVHQAVKIGQSLSSLTS 3458
Query: 6377 GDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII 6436
+ V+ + + L R S + ++ + + L F D + LA+ +
Sbjct: 3459 PAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAE----V 3514
Query: 6437 LQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGD------KLQVEQPSMQELS 6490
KL++VF + + + Q A+ + I+ K+ D + ++Q + +E+
Sbjct: 3515 EDKLSSVFVKDFKQDVLHRQHADH--LALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVL 3572
Query: 6491 KLQD-------MYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMA--GD 6541
+Q+ Y ++ + L Q L ++++ ++L L +E++A G
Sbjct: 3573 LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGG 3632
Query: 6542 QKIIVSSKEEIQQLLDKHKEYFQGLESHMILTET---LFRKIISFAVQKETQFHTELMAQ 6598
Q + E+I Q + KE + + H ++ +T + R ++ + + +L++
Sbjct: 3633 QS---PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSD 3689
Query: 6599 AS------------------AVLKRAHK----RGVELEYILETWSHLDE------DQQEL 6630
A+ A ++R+ + EL ++ ET L +Q +
Sbjct: 3690 ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQT 3749
Query: 6631 SRQLEVVESSIPSVGLVEENEDRLIDRI-----TLYQHLKSSLNEYQPKLYQVLDDGKRL 6685
+ QL+V ++ + +++ D L T + K+ L E L Q + L
Sbjct: 3750 TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY-EAISL 3808
Query: 6686 LISISCSDLESQ---LNQLGEC------WLSNTNKMSKELHRLETILKHWTRYQSESADL 6736
L S + LE +NQ E W+ T + +L + + Q E L
Sbjct: 3809 LNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQL 3868
Query: 6737 IHWLQSAKDR----LEFWTQQSVTVPQELEMVRDHL----NAFLEFSKEVDAQSSLKSSV 6788
+ K L+ Q P+E EMV + N + + +EV ++
Sbjct: 3869 RESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEA 3928
Query: 6789 LSTGNQLLRL-KKVD--TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAI 6845
+S Q+ K++ TL + SR+ + IPA +K+ + D ++ A
Sbjct: 3929 VSQSTQITEFHDKIEPMLETLENLSSRL-----RMPPLIPAEVDKIRECISD---NKSAT 3980
Query: 6846 SEVMSWISLMENVIQKDEDNIKNSIG------YKAIHEYLQKYKGFKIDINCKQLTVDFV 6899
E+ E + ++ E+ I S G K I + L + F DI + +
Sbjct: 3981 VELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIK 4040
Query: 6900 NQSVLQISSQ--------------------DVESKRSDKTDFAEQLGAMNKSWQILQGL- 6938
VL+++ + D+ES D + +Q+ A + GL
Sbjct: 4041 FLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLH 4100
Query: 6939 ----------------------------VTEKIQLLEGLLESWSE--------------Y 6956
+ E E L ++W E Y
Sbjct: 4101 EELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQY 4160
Query: 6957 ENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGL 7015
++ +Q + W + +L +G D +V++ L + ++ + + ++ E+EK+ G
Sbjct: 4161 QDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGE 4220
Query: 7016 ALIQNKKEDVS-SIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSY 7074
+++ ++ I+ L EL W NL + + L+ L + A +++ S+
Sbjct: 4221 LMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSW 4280
Query: 7075 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 7134
L L R ++G + ++V++ L++D+ + +++ N+LL+
Sbjct: 4281 LTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDD 4340
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7194
+L + L+ +N W ++L++ E+ Q ++ LQ Q + + + + E + +
Sbjct: 4341 ASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSAS 4400
Query: 7195 LKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGE-QLKQQVDASAASAIQS 7253
+ A +++ T + +L L +++ L + G L + D+ + S +
Sbjct: 4401 KPTGGLPETAREQLDTHM----ELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQ 4456
Query: 7254 DQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSS 7313
L Q + + ++++ L+ + F SL+ W+ AE+ L P S
Sbjct: 4457 SVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPP-SL 4515
Query: 7314 DLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL--NDKEIKRMQNL----NRHWS 7367
L+T+ ++EE K + ++ + L++ G +L +++ ++NL W
Sbjct: 4516 ILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE 4575
Query: 7368 LISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKL--AVEISGNYQHLLEQQRA 7425
+ ++ ER L + + F E + +++L E L +EIS + + Q
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635
Query: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQV-DDRDEFNLKLTLLSNQWQGVIRRAQQRR 7484
H+ FQ + +Q + + I G+ L E+ + +D + + L + ++W V ++ +R+
Sbjct: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQ 4695
Query: 7485 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7544
++ + ++ + + L WL +V ++ V L L D + +K
Sbjct: 4696 HKLEEALLFSGQFMDALQALVDWLYKVE-PQLAEDQPVHGDLDLVMNLMDAHKVFQKELG 4754
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
++ G+ + +G++L+ ++ ++ +L E+ +W + ++ +L LK
Sbjct: 4755 KRTGTVQVLKRSGRELIENSRDDT-TWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQA 4813
Query: 7605 EKCEKGIADSLEKLRTFKKKL--SQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7662
E + LE L ++ L +LPD E L + KE V D+
Sbjct: 4814 EVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVA 4873
Query: 7663 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7722
+ + + A D I+ + + +++ ++EE+ +Q++ L+E +E +EL
Sbjct: 4874 MGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELL 4933
Query: 7723 EWLTQMESKVSQNGDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERL---- 7772
W+ E+ + Q I + I+++K + + EE+ Q + ++ + +R
Sbjct: 4934 AWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEP 4993
Query: 7773 --AKASHESKA-----------------SEIEYKLGKVND---RWQHLLDLIAARVKKLK 7810
A +S++ S+ E K ++N RWQ + L R +KL
Sbjct: 4994 THAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLN 5053
Query: 7811 ETLVAVQQL 7819
+ L +++L
Sbjct: 5054 DALDRLEEL 5062
Score = 269 bits (688), Expect = 8e-71
Identities = 808/4676 (17%), Positives = 1769/4676 (37%), Gaps = 614/4676 (13%)
Query: 1128 EDPDKWKDYTSRFSEFSSWIS------------TNETQLKGIKGEAIDTANHGEVKRAVE 1175
E +W++Y SR WI N +LK + + I + E + +
Sbjct: 311 EVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI---HFKETEILAK 367
Query: 1176 EIRNGVTKRGETL--SWLKSRLKVLTEVSSENEAQKQGDEL--------AKLSSSFKALV 1225
E G + L W++ L + N+ +++ +L L + + L
Sbjct: 368 EREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLE 427
Query: 1226 TLLSEVEKMLSNFGDCVQYKEIVKNSLE---ELISGSKEVQEQAEKIL---DTENLFEAQ 1279
LL K+ + +C + + KN+L+ + + VQ +++ I+ + E L
Sbjct: 428 LLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQL 487
Query: 1280 QLLL-----HHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKL--ESTLDGLE 1332
Q+ L + + + ++ + +Q ++ + L +GH +L STL
Sbjct: 488 QVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTH 547
Query: 1333 RSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL--SFSSLESLSSELEQTK 1390
E + + W R + +V + RF+ S +E + +LE+
Sbjct: 548 LKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERA- 606
Query: 1391 EFSKRTESIAVQAENLVK-EASEIPLGPQNKQLLQQQAK-------SIKEQVKKLEDTLE 1442
E+ S+ +Q E S LG K+ + K S E + KLE
Sbjct: 607 EWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLE---T 663
Query: 1443 EDIKTMEMVKTKWDHFGSNFETLS------VWITEKEKELNALETS--SSAMDMQISQIK 1494
+ K E + H S + +S +W+ EKE+E A + S +S + + +
Sbjct: 664 QYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFS 723
Query: 1495 VTIQEIESKLSSIVGLEEEAQSF------AQFVTTGESARIKAKLTQIRRYGEELREHAQ 1548
E+E K L++ A+ A+ SA ++++L +++ + +H +
Sbjct: 724 ELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVK 783
Query: 1549 CLEGT-ILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1607
E T S ++ E LR +Q S+ K +S + +LQ+ MD +
Sbjct: 784 --ENTAYFQFFSDARELESFLRNLQDSI-----KRKYSCDHNTSLSRLEDLLQDSMDEKE 836
Query: 1608 ALESLSSAITAFSASARKVV-------------------------------NRDSCVQEA 1636
L S++ + ++ +V D CV E
Sbjct: 837 QLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLED 896
Query: 1637 AALQQQY-----------------------EDILRRAKERQTALENLLAHWQRLEKELSS 1673
+ + ++ +D + A + + + ++A W +L S
Sbjct: 897 NSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKS 956
Query: 1674 FLTW--------------LERGEAKASSPEMDIS----------------------ADRV 1697
++W LE+ + A I ADR+
Sbjct: 957 LISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRL 1016
Query: 1698 KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1757
++E E++ +A ++ S + KE + ++K ++L LE+ ++R
Sbjct: 1017 RLEEEVEACKARFQHLMK-----SMENEDKEETVAKMYISELKNIRLRLEEYEQR----- 1066
Query: 1758 QIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKD-H 1816
+ KRI L S + + + L + Q S++ + + H+
Sbjct: 1067 --VVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPS 1124
Query: 1817 AAEVESKKGELQSL---QGHLAKLGS--LGRAEDLHLLQGKAEDCFQLFEEASQVVERRQ 1871
++ V + + EL L H+ L + L + + + ++ +D L + + + +
Sbjct: 1125 SSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEE 1184
Query: 1872 LALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAV 1931
+ L+ L+ L++H S LR V+ NS+ + I K A Q ++ +
Sbjct: 1185 VVLADLSA-LEAHWS---TLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNL 1240
Query: 1932 SLD-----GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVL 1986
L+ G + ++H I E R S + ++ G+ L E A +
Sbjct: 1241 DLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEM 1300
Query: 1987 KKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLK 2046
K Q + +L E + ++T E + L Q + Q + +E +L K
Sbjct: 1301 MKPGQAEDSRVLS--EQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYK 1358
Query: 2047 ----------DKAKQIAQKDVAFAPE-----------VDREINRLEVTWDDTKRLIHENQ 2085
K +++ A E V ++ D +RL E +
Sbjct: 1359 AFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEK 1418
Query: 2086 GQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYK 2145
+ + + + L VS + N T + K+ D++ A + + ++ K
Sbjct: 1419 VVEEEKQEHVEKVKELLGWVSTLARNTQGK-ATSSETKESTDIEKAILEQQVLSEELTTK 1477
Query: 2146 QKDLDN-------FTSKGKHLLSEL-KKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMD 2197
++ + F +K H LSE KK S + + D + ++L+ +
Sbjct: 1478 KEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLA 1537
Query: 2198 RLRVSLSIWDDVLSTRDEIE---GWSNNCVPQMA--------ENISNLDNHLRAEELLKE 2246
++ + ++E W +A +++S L + + LK+
Sbjct: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN---QSDLKD 1594
Query: 2247 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ---KLEHAKEITEVAK 2303
+ +++N+A + + E + +P +L + L Q + E +E T VA+
Sbjct: 1595 LQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQ 1654
Query: 2304 GTLKDFTAQSTQVE--------------KFINDITTWFTKVEES----LMN--------- 2336
L++ + Q E K I+ + W T V S L N
Sbjct: 1655 KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSG 1714
Query: 2337 --------------CAQNETCEALKKVKDIQK----ELQSQQSN-ISSTQENLNSLCRKY 2377
N+ E L K ++ K EL SQQ N I +TQ L +
Sbjct: 1715 ASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHG 1774
Query: 2378 H--SAELESLGRAMTGLIKKHEAVSQLCSKTQ----ASLQESLEKHFSESMQEFQEWFLG 2431
H + E + + + G +K+ + S S+ + +LQ+ L+K F + +EF+ W
Sbjct: 1775 HNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK-FLQDHKEFESWLER 1833
Query: 2432 AKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY--------AH 2483
++ + + L + L + + V + L VT GQ +
Sbjct: 1834 SEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGK 1893
Query: 2484 LSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEME- 2542
+I + +++++ A E + A +C + L + F++ L W+ E
Sbjct: 1894 EPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEA 1953
Query: 2543 --ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQ 2600
E+ ++ + + E+ +++ L E E L K+++ ++ EG A
Sbjct: 1954 NVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--DIMEIEGEPAPD 2011
Query: 2601 EGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACA 2657
+ +L+ Q+L E+ Q A+ + ++++E+L+S+ + ++ L
Sbjct: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071
Query: 2658 E-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQ 2713
+ S+L S ++ L + QDI K E M + + +++ V+Q +
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV----TRFMETADSTTAAVLQGK 2127
Query: 2714 LETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGL 2773
L + + + + +S+L+ ++ Q + +L+Q+ME+ + + QP +
Sbjct: 2128 LAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDI 2187
Query: 2774 KEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMT 2833
F + L + + +++ L L+ + + +D Q L+ F ++
Sbjct: 2188 THFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQ-NLRKDFTELQK 2246
Query: 2834 VAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKEL 2893
KE+ + + + V F WL + + ++ S + +K++ +K L
Sbjct: 2247 TVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP-TETSMSAKELEKQIEHLKSL 2305
Query: 2894 IDS--------REIGASRLSR----VESLAPEVKQNT------------------TASGC 2923
+D EI S +E AP+ + T T
Sbjct: 2306 LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL 2365
Query: 2924 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2983
+ +M + +++ + + Q L+ ++++M +E + + Q LE +L
Sbjct: 2366 TEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM----EEVHKEANSVLQWLESKEEVL 2421
Query: 2984 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3043
K+ + + E + + L L++ P+ + +K L L L TY
Sbjct: 2422 KS----MDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGL------LVTY 2471
Query: 3044 SGKVSG-----LIKEYNCLCLQASKGCQNKEQILQQR------FRKAFRDFQQWLVNAKI 3092
+ +E N +A++ +++ L++ F+ A + WL+ ++
Sbjct: 2472 PNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKEL 2531
Query: 3093 TTAKCFDIPQNISEVSTSLQKIQEFLSESE--NGQHKLNMMLSKGELLSTLLTKEKAKGI 3150
+ + + ++ Q++Q L E E QH+ ++G L +
Sbjct: 2532 MMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQV 2591
Query: 3151 QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT----EKMVHES 3206
Q ++ + + W L+ + S ++ ++ ++ E +QD K +++ +S
Sbjct: 2592 QKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQ---ELLQDLSEKVRAVGQRLSVQS 2648
Query: 3207 SNRLYDLPAKRR--EQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQL 3264
+ K++ E +++S LE++ + L ++ L Q + R+ +
Sbjct: 2649 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 2708
Query: 3265 SSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLD 3324
+ L +L ++++RL +A QF EL+ W+ D C ++ L
Sbjct: 2709 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 2768
Query: 3325 SRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP-EGIPTIQQQLQSVKDMWASLLSA 3383
S+ + E + ++IV GES+L + P E T+Q QL +K+ W L
Sbjct: 2769 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKK 2828
Query: 3384 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLN 3443
+S+L+ + K YQ V W++ +A ++E ++ ++++L +LN
Sbjct: 2829 TADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLN 2888
Query: 3444 EEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKL 3497
EV SLLE + + + E + E + + A+ E + E++
Sbjct: 2889 -EVEKRRSLLEILNSAADILINSSEADEDGIRD-EKAGINQNMDAVTEELQAKTGSLEEM 2946
Query: 3498 VRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLN 3557
+ +E+Q K E + + +L+ + L A ++ ++L++L+ QAL
Sbjct: 2947 TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSN----KNLEKLRAQQEVLQALEP 3002
Query: 3558 SVLHTRE--DVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
V + R + P D + L + Q E + + N + +ME K +
Sbjct: 3003 QVDYLRNFTQGLVEDAPDGSDAS--QLLHQAEVAQQEFLEVKQRVN---SGCVMMENKLE 3057
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQE-------------ILDESHVNSRMGC 3662
+ ++ ++ ++ DE++ +GA ++ L++ HV ++
Sbjct: 3058 GIGQF--HCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHV-LKLDI 3114
Query: 3663 QATQLTSRYQAL------LLQVLEQIKFLEEEIQSL--------EESESSLSSYSDWYGS 3708
+A++ R+ LL + +++ L ++ L E+ E +L D+Y
Sbjct: 3115 EASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRK 3174
Query: 3709 THKNFKNVATKIDKVDTV--MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEG 3766
K + T ++ + + ++G +++ + L D + + + V L +G
Sbjct: 3175 L-KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQG 3233
Query: 3767 EAERLRKE-----IHDHMEQLKELTSTVRKE----HMTLEKGLHLAKEFSDKCKALTQWI 3817
+ K+ + ME++ +T+ K+ L++ L +F D + L W+
Sbjct: 3234 LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWL 3293
Query: 3818 AEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL---LELVQD 3874
A+ +E++ + P E KAQ+ + K LQ+ + + +V ++ +G + EL
Sbjct: 3294 ADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADR 3353
Query: 3875 VTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 3934
+ +++ L+S + +L S A +++ ED L + +T +D L K+
Sbjct: 3354 EKITGQLESLESRWTELLSKAAARQKQL---EDILVLAKQFHET-AEPISDFLSVTEKKL 3409
Query: 3935 VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQP 3994
++ GT+ +A +++LE +++ H + + LS++ P+ Q
Sbjct: 3410 ANSEPVGTQ---TAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL---TSPAEQG 3463
Query: 3995 PLSRAEAIKQVKHFR---------ALQEQART-----------YLDLLCSMCD-LSNASV 4033
LS Q ++ AL +QA + L+ L + D LS+ V
Sbjct: 3464 VLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFV 3523
Query: 4034 KTTAKDIQQ---------TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQN 4084
K +D+ E+ + +K Q + G +K E + +Q ++L
Sbjct: 3524 KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ---EKLDG 3580
Query: 4085 MKRRHSELELNIAQNM--VSQVKDFVKKLQSKQASVNTIIEKVNK--LTKKEESPEHKEI 4140
+K R++++ + ++ + + Q + K QS + + +V + T +SP ++I
Sbjct: 3581 IKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQI 3640
Query: 4141 NHLNDQWLDLCRQ--SNNLCL--------------------------------------- 4159
+ +L ++ + L L
Sbjct: 3641 PQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDT 3700
Query: 4160 --QREED----LQRTRDYHDCMNVVEVFLEKFTTEWDNLA--RSDAESTAVHLEALKKLA 4211
QR ++ +QR++ Y + ++ + + L R + + T L+ K +
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 3760
Query: 4212 LALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTN 4271
+ + K ++++L + ++ + K +++E+T L Q++ + L +
Sbjct: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSER----YAR 3816
Query: 4272 LEELNVVQSRF----QELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327
LE V+ ++F +EL W EE + IA Q P P +DH + + E +
Sbjct: 3817 LERAQVLVNQFWETYEELSPWIEETRALIA----QLPSP------AIDHEQLRQQQEEMR 3866
Query: 4328 MLLKSLIKDADRV---------MADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
L +S+ + + + +L E +++++ A++ + + V QR L+
Sbjct: 3867 QLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC----KSAQASLKT 4434
+A+S+ TQ + ++ E L+P +V K ++ C KSA L+
Sbjct: 3927 EAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDK-IRECISDNKSATVELEK 3985
Query: 4435 YQNEVTGLWAQGRELMKEVTEQEK----SEVLGKLQELQSVYDSVLQKCSHRLQELEKNL 4490
Q L +G EL+ +K E+ KL ++ ++ + + R + L
Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045
Query: 4491 VSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLT 4550
+ F D +K + + + S + Q+ + I E++ L
Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105
Query: 4551 LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE 4610
++ G ++ + E + + + ++ + + + K++ K+++A+ A +Y ++
Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQ 4165
Query: 4611 LTTQSLSELEAQFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQK---- 4665
L + M V TDL V++ L+ + EV +++LN +
Sbjct: 4166 AMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV---EVYQQQIEMEKLNHQGELM 4222
Query: 4666 -KEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLK 4724
K+ T + + + L L+ L + R LE A + + ++L L
Sbjct: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282
Query: 4725 SVKE---EQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE 4781
+E Q ++ + E +L +H L + ++ V +L
Sbjct: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS 4342
Query: 4782 KARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVY 4841
R ++++ + + E + +S + Q+ F +E+ L L R++++LS
Sbjct: 4343 SLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKP 4402
Query: 4842 LDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELIS-ADLEHSLAELS 4900
+ +E++ ++++ N L K + + S + E S+A L
Sbjct: 4403 TGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLE 4462
Query: 4901 ELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG-NGLDVESAEE 4959
+ + + R++ L E + + Q +WL A++ L +A L + +
Sbjct: 4463 QKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLS 4522
Query: 4960 NLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRM---SR 5016
++ H F + + + EL L L + ++ + S++ R +++ S
Sbjct: 4523 QIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI 4582
Query: 5017 DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKA 5076
+ G +D ++ Q+H+ A +++I+ + D E L + L ++ + + +LS+HK
Sbjct: 4583 ERGRSLDDARKRAKQFHE---AWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLSKHKE 4638
Query: 5077 LVSVVNSFHEKI-VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKIL 5135
+ + + EKT L + V +W + + +++ L
Sbjct: 4639 FQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKL 4698
Query: 5136 EDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQS 5195
E+A+ F + ++ + + +++ +L ++ L++ H F EL ++
Sbjct: 4699 EEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTG 4758
Query: 5196 ALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5255
+ +L++ ++++ T + L QE++ D + ++ ++Q LK E
Sbjct: 4759 TVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRWDTVCKLSVSKQSR---LEQALKQAE 4814
Query: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQL-EELQILLTEATNHRQNIEKMAEEQ 5310
+ ++ + W+ E ++ T+ L ++ + L + H++ ++K+ E++
Sbjct: 4815 VFRDTVHMLLEWLSEAEQ-----TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKR 4865
Score = 258 bits (659), Expect = 2e-67
Identities = 839/4722 (17%), Positives = 1769/4722 (37%), Gaps = 741/4722 (15%)
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEK--ML 1235
+N T ETL L+++ L E SS Q L K S A + L+E E+ +
Sbjct: 648 QNFHTSYAETLGKLETQYCKLKETSSFRMRHLQS--LHKFVSRATAELIWLNEKEEEELA 705
Query: 1236 SNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAK 1295
++ D +N EL +E Q+ + DT A+ L L + + + A
Sbjct: 706 YDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDT-----AELLSLENHPAKQTVEAY 760
Query: 1296 KRDVQQQIAQAQQ---------GEGGLPDRGHEELRKLESTLDGLERSRERQ-------- 1338
VQ Q+ +Q E + + R+LES L L+ S +R+
Sbjct: 761 SAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTS 820
Query: 1339 ----ERRIQVTLRKWERFETNKETVVRYLFQTGS-------SHERFLSFS-SLESLSSEL 1386
E +Q ++ + E+ +K +V + ++ + S + L + S++++
Sbjct: 821 LSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYR 880
Query: 1387 EQTKEFSKRTESIAVQAENLVKEASEIPLG-------------PQNKQLLQQQAKSIKEQ 1433
+ K E + K P G P NK ++ ++ +
Sbjct: 881 QIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSY 940
Query: 1434 VKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQI 1493
K + + + T ++ W++ + + + W EK + E ++Q
Sbjct: 941 QKVMALWHQLHVNTKSLIS--WNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYE 998
Query: 1494 KVTIQEIESKLSSIVG---LEEEAQS----FAQFVTTGESAR-----IKAKLTQIRRYGE 1541
+S L S+ LEEE ++ F + + E+ K +++++
Sbjct: 999 DFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRL 1058
Query: 1542 ELREHAQCLEGTILG----------------HLSQQQKFEENLRKIQQSVSEFEDKLAVP 1585
L E+ Q + I +++Q+ +E+L++++ + K
Sbjct: 1059 RLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSF 1118
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYED 1645
+ S++ + E L + ++ + T + + V +Q+A L + YE
Sbjct: 1119 LHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEI 1178
Query: 1646 ILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQL 1705
L + + L L AHW L LS V+ + +
Sbjct: 1179 KLSQEEVVLADLSALEAHWSTLRHWLSD-------------------------VKDKNSV 1213
Query: 1706 IQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP---QIINK 1762
L E+ +K++ + S + D++ + QL ERW + +I
Sbjct: 1214 FSVLDEEIAK-----AKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268
Query: 1763 RINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1822
+ +Q V+ +++ L+ WI+ +TT++ +M + E
Sbjct: 1269 ELESIQEVLGDYRACHGTLIK---WIE------ETTAQQEMMK-----------PGQAED 1308
Query: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQ 1882
+ + L A + R Q K + C + ++ S +V+ +L L F++
Sbjct: 1309 SRVLSEQLSQQTALFAEIERN------QTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE 1362
Query: 1883 SHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQY 1942
S G R++ + SD I ++ D AL + +S A
Sbjct: 1363 SQQKSPGKRRRMLSS-----------SDAITQEFMDLRTRYTALVTLTTQHVKYISDALR 1411
Query: 1943 HLKIGSSEQRTSCRATADQLCGEVERIQNLLG-----TKQSEADALAVLKKAFQDQKEEL 1997
L+ E+ + ++ VE+++ LLG + ++ A + K D ++ +
Sbjct: 1412 RLE----EEE---KVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI 1464
Query: 1998 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDV 2057
L+ EE T K KE +A++ ++F L H H+L +K K+
Sbjct: 1465 LEQQVLSEELTTK---KEQVSEAIKTS-QIF------LAKHGHKL---SEKEKK------ 1505
Query: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
++ ++N L + D C G + + Q L+S ++ E +
Sbjct: 1506 ----QISEQLNALNKAYHDL----------CDGSAN---QLQQLQSQLAHQTEQKTLQKQ 1548
Query: 2118 TRTTIKDQEDL-KWAF-SKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2175
T + EDL W ++ A ++ Q+DL S L+K + SD ++
Sbjct: 1549 QNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL-----------SALQK-NQSDLKDLQ 1596
Query: 2176 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2235
D+++ + V + +E M+ + LS ++ + R+++ Q E L
Sbjct: 1597 DDIQNRATSFATVVKDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQ 1647
Query: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEH 2294
R + KE E V + + E +L E K ++ D + + + Q L +
Sbjct: 1648 EETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTN 1705
Query: 2295 AKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2354
+ +++ +L+ +T +N + E L ++ CE +K +
Sbjct: 1706 LPGMEQLSGASLEKGALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQ 1750
Query: 2355 ELQSQQSN-ISSTQENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA--- 2408
EL SQQ N I +TQ L + H+ E + + + G +K+ + S S+ +
Sbjct: 1751 ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV 1810
Query: 2409 -SLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQ 2467
+LQ+ L+K F + +EF+ W ++ + + L + L + + V +
Sbjct: 1811 QTLQDELQK-FLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHK 1869
Query: 2468 SKLDAVTQEGQTLY--------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQD 2519
L VT GQ + +I + +++++ A E + A +C + L
Sbjct: 1870 GDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNM 1929
Query: 2520 CASELGSFEDQHRKLNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2576
+ F++ L W+ E E+ ++ + + E+ +++ L E
Sbjct: 1930 LLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQV 1989
Query: 2577 ARESLDKLSQRGQLLSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
E L K+++ ++ EG A + +L+ Q+L E+ Q A+ +
Sbjct: 1990 PVEKLQKVAR--DIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQS 2047
Query: 2634 EALEEALQSMWFWVKAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLN 2689
++++E+L+S+ + ++ L + S+L S ++ L + QDI K E
Sbjct: 2048 QSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATRE 2107
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
M + + +++ V+Q +L + + + + +S+L+ ++ Q +
Sbjct: 2108 MVT----RFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLS 2163
Query: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE 2809
+L+Q+ME+ + + QP + F + L + + +++ L L+ +
Sbjct: 2164 GKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGF 2223
Query: 2810 KTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEE 2869
+ +D Q L+ F ++ KE+ + + + V F WL +
Sbjct: 2224 ALDLCQHQDRVQN-LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGS 2282
Query: 2870 LHRWSDMSGDSSATQKKLSKIKELIDS--------REIGASRLSR----VESLAPEVKQN 2917
+ ++ S + +K++ +K L+D EI S +E AP+ +
Sbjct: 2283 IPP-TETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGK 2341
Query: 2918 T-----------------------TASGCEL-------------MHTEMQALRA------ 2935
T T C++ +H ++L+A
Sbjct: 2342 TGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRME 2401
Query: 2936 ----------DWKQWEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQAL 2976
W + ++ V ++ + + V A S + F ++ Q +++
Sbjct: 2402 EVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVK 2461
Query: 2977 EQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL------ 3030
E + LL T+ K EE+ W + E+ A Q+ + E+ S L
Sbjct: 2462 EALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAA 2518
Query: 3031 -NELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVN 3089
++L + + G + L + N L Q + + Q + + F + +Q
Sbjct: 2519 ESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEA 2573
Query: 3090 AKITTAKCFDIPQNISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTL 3141
A+ D+ + S+V LQ I E + + +++ + K ELL L
Sbjct: 2574 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 2633
Query: 3142 LTKEKAKG----IQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VS 3188
K +A G +Q+ ++ E K + S LE L ++K+ + +
Sbjct: 2634 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG 2693
Query: 3189 AEPIQDWLSKTEKMVHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY------- 3233
+ ++D L K + V L DL A R + Q+ Q + +E+ +
Sbjct: 2694 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 2753
Query: 3234 -------EPQLNRLKEKAQQLWEGQAA---------------------------SKSFRH 3259
+L RL+ + Q+ E Q + ++ ++
Sbjct: 2754 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 2813
Query: 3260 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3319
++ +L + + LS T ++ SRL + + ++ +++L W+ D + S T D
Sbjct: 2814 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLD 2872
Query: 3320 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWAS 3379
L+S L+ +A+L+ + EK + I+ +L N+S + ++D A
Sbjct: 2873 PVQLESSLLRSKAMLN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAG 2924
Query: 3380 LLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKA 3439
+ +L+ +R+F ++E + E + E+ D +
Sbjct: 2925 INQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACS 2983
Query: 3440 KLLNEEVLSYSSLLETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQE 3485
E++ + +L+ +E + G+ E + L Q+ + +++
Sbjct: 2984 NKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQ 3043
Query: 3486 RAKEAVTKSE-KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ- 3543
R E KL + Q + R + F L ++LD + D + ++ + D++
Sbjct: 3044 RVNSGCVMMENKLEGIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRL 3102
Query: 3544 ------ELQVHCAEGQALLNSVLHTREDVIPSGIP---QAEDRALESLRQDWQAYQHRLS 3594
L++ +A +L + G+ +A ++ L + +A Q +L
Sbjct: 3103 FLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLE 3162
Query: 3595 ETRTQFNNVVNKLRLMEQKFQQVDE-----WLKTAEEKKWHEEVTAYR----DEVEEVGA 3645
T + + KL+ + +E W+ E + ++++ ++ ++V+ +
Sbjct: 3163 LTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQM 3222
Query: 3646 RAQEI--LDESHVNSR--------MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES 3695
+ Q++ L + + S + ++ +R+ L +V ++I L+E + +
Sbjct: 3223 KLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282
Query: 3696 ESSLSSYSDWYGSTHK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ +L W T + N K + + V + +KL L+ LL D + +L++
Sbjct: 3283 QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDMLQA- 3339
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
+G R + E + E++ ++ + EL S LE L LAK+F + +
Sbjct: 3340 --EGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV 3872
++ +++ ++ L E + + + Q+ ++K+L++ + +H V + G++L L
Sbjct: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLT 3457
Query: 3873 QDV---TLKDKIDQLQSDY---QDLCSIGKAMMEE------------------IAGFEDR 3908
L +KID LQ+ Y QD C A++++ +A ED+
Sbjct: 3458 SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDK 3517
Query: 3909 LNNL---QMKGDTLIGQCADHL--------------------QAKLKQN-------VHAH 3938
L+++ K D L Q ADHL QA LKQ +
Sbjct: 3518 LSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 3577
Query: 3939 LQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR 3998
L G K Y+ I T+ + ++LE Q Q T ++ WL V+ +L S +
Sbjct: 3578 LDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG----GQ 3633
Query: 3999 AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLT 4058
+ +Q+ F+ Q++ + + + D N + + + + KLV N
Sbjct: 3634 SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN-- 3691
Query: 4059 QGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK-----KLQS 4113
E+ K + + + + D +Q ++ + +A V++ K + +L+
Sbjct: 3692 ---EQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKLMALGPIRLEQ 3746
Query: 4114 KQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE-EDLQRTRDYH 4172
Q + ++K + E+ + C + LQ + E L + +
Sbjct: 3747 DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAI 3806
Query: 4173 DCMNV--------VEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+N +V + +F ++ L+ E+ A+ + L A+ ++ + E++
Sbjct: 3807 SLLNSERYARLERAQVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEM 3865
Query: 4225 KDQKQKMIEH----------------LNLDDKELVKEQTSHLEQRWFQLEDLIKRK---I 4265
+ ++ + EH LN ++ E+V+E+ E + Q+++ ++++ +
Sbjct: 3866 RQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925
Query: 4266 QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSP----PPDMAQNLLMDHLAICS 4321
+V+ ++ + + ++E E N++ L+ P D + + D+ +
Sbjct: 3926 DEAVSQSTQITEFHDKIEPMLETLE----NLSSRLRMPPLIPAEVDKIRECISDNKSATV 3981
Query: 4322 ELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRR-----KY 4376
ELE Q ++L + + ++ ++ + K + D + + + R K+
Sbjct: 3982 ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKF 4041
Query: 4377 LNKA-LSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTY 4435
L+ L+EK + MA T I+ + + E + P + +QV+ ++ +
Sbjct: 4042 LDVLELAEKFWYDMAALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGL 4099
Query: 4436 QNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH 4495
E+ + G +L+ E EK EV + E+ + ++++ + RL++LE + +
Sbjct: 4100 HEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQ 4159
Query: 4496 FKEDFDKACHWLKQADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQSPEYENLLLTL 4551
+++ WL I T P + +N + ++ +++ + +Q E E L
Sbjct: 4160 YQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL---- 4215
Query: 4552 QRTGQTILP-SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE 4610
G+ +L + +E D + E L L + + + +K++ A+LA ++ +E
Sbjct: 4216 NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4275
Query: 4611 -----LT-TQSLSE-----------LEAQFLRMSKVPTDLAVEEAL--SLQDGCRAILDE 4651
LT T+ L + +E + + + D+ +A ++ +L+
Sbjct: 4276 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4335
Query: 4652 VAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQE 4711
AG D+ + + + Q W+ ++ + + + +Q S L+ + E
Sbjct: 4336 SAG-----DDASSLRSRLEAMNQCWE--------SVLQKTEEREQQLQSTLQQAQGFHSE 4382
Query: 4712 HEKMCQQLER---QLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHL 4768
E +L R QL + K + +++Y L + +L + + L
Sbjct: 4383 IEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML 4442
Query: 4769 EDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDW 4828
D + K + + + +++S + E ++ E + + +FQ + ++W
Sbjct: 4443 ---LSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINW 4499
Query: 4829 LRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKEL 4887
L + L+ L L + +I + ++ EV + + L + KF K+
Sbjct: 4500 LTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQD 4559
Query: 4888 ISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQL 4947
+ ++ S + +Q ++ R +L + + +++++ ++ DWLEDA
Sbjct: 4560 VVLIKNLLVSVQSRWEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDWLEDA------ 4612
Query: 4948 AGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASL 5007
E +L S +E + D+ L + TL GK Q V
Sbjct: 4613 ----------ESHLDSELEISNDPDKIKLQLSKHKEFQKTLG------GK----QPVYDT 4652
Query: 5008 ELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEA 5067
+R+ R ++ T D QK + + + K H+
Sbjct: 4653 TIRTGRALKEK----------TLLPEDSQK----LDNFLGEVRDKWDTVCGKSVERQHKL 4698
Query: 5068 EEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQ-----RWT 5122
EE L + + + + + +E + ++ + D V+Q R
Sbjct: 4699 EEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTG 4758
Query: 5123 RLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEY 5182
++ + + +++E++ D+ T ++++ + D + KL S + +A L +
Sbjct: 4759 TVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLEQA-LKQAEVF 4816
Query: 5183 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEK-VK 5241
DT + LE A +QTL GA P E L I ++ ++EK V
Sbjct: 4817 RDTVHMLLEWLSEA-----EQTLRFR--GALPDDTEA--LQSLIDTHKEFMKKVEEKRVD 4867
Query: 5242 TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQ 5301
N + E+ I ++K W+ TI I A+ EE+ LT A H+Q
Sbjct: 4868 VNSAVAMGEVILAVCHPDCITTIKHWI----------TI-IRARFEEV---LTWAKQHQQ 4913
Query: 5302 NIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSR 5361
+E E L +L +Q AE L + ++ I I V+ A Q
Sbjct: 4914 RLETALSELVANAELLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFME 4970
Query: 5362 QIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQ 5421
++ + D+ + K K A +K G L + L Q+
Sbjct: 4971 EMTRKQPDVDRVTKTYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPPPMPILSQS-- 5024
Query: 5422 LGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNE 5463
+ +I +L+ QQ A R KLN A LEE E
Sbjct: 5025 --EAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064
Score = 256 bits (655), Expect = 5e-67
Identities = 754/4224 (17%), Positives = 1580/4224 (37%), Gaps = 545/4224 (12%)
Query: 583 SVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKM 642
++E A V + + A W L V +S+ S W+ + +Q W + EK+
Sbjct: 929 AIEMASRVEQSYQKVMALWHQLHVNTKSLIS--------WNYLRKDLDLVQTW--NLEKL 978
Query: 643 LNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFM 702
+ + +NL + + + L D + L++++ R++ L
Sbjct: 979 RSSAPGECHQIMKNLQAHYEDFL-QDSRDSVLFSVADRL---RLEEEVEACKARFQHLMK 1034
Query: 703 EVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQR 762
M+ KE T + +S K + LE V IQ L
Sbjct: 1035 S---------MENEDKEETVAKMYISEL-----KNIRLRLEEYEQRVVKRIQSLASSRTD 1080
Query: 763 VPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS-PLLYESQQLL 821
I + H T+E Q+ ++ A K L + S P L LL
Sbjct: 1081 RDAWQDNALRIAEQEH--TQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLL 1138
Query: 822 IPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEK 881
+ + +++ Y L K+ + + V+ R Q + L + ++ L+ +E L+ +E
Sbjct: 1139 VEKMDHVYGLSTVY--LNKL-KTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEA 1195
Query: 882 GSQSVQKFVTLSNVL-KHFDQTRLQRQIADIHVAFQSMVKKTG----DWKKHVETNSRLM 936
+++ + LS+V K+ + L +IA V + M + T D +++ E S+L
Sbjct: 1196 HWSTLRHW--LSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQ 1253
Query: 937 KKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDIL 996
+++ A+LE I Q LE +E+L D R + L E T
Sbjct: 1254 ERWHRVIAQLE----IRQSELESI---QEVLG---------DYRACHGTLIKWIEETTAQ 1297
Query: 997 PEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLM 1056
E + G E R L +Q ++ A +E +T+LD+ K
Sbjct: 1298 QEMMKPGQAEDSRVLSEQLS-----------------QQTALFAEIERNQTKLDQCQKFS 1340
Query: 1057 PQEGSEKIIKEHRV------FFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHV 1110
Q + I+K++ + F + ++R L + D T T V
Sbjct: 1341 QQYST--IVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMD--LRTRYTALV 1396
Query: 1111 TLKELRAAIDSTYRKLMEDPDKW-----KDYTSRFSEFSSWISTNETQLKGIKGEAIDTA 1165
TL S + +E+ +K +++ + E W+ST +G K + +T
Sbjct: 1397 TLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQG-KATSSETK 1455
Query: 1166 NHGEVKRAVEEIR----NGVTKRGETLSWLKSRLKVLTEVS---SENEAQKQGDELAKLS 1218
++++A+ E + TK+ + +K+ L + SE E ++ ++L L+
Sbjct: 1456 ESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALN 1515
Query: 1219 SSFKALVT-LLSEVEKMLSNFGDCVQYKEIVK--NSLEELISGSKEVQEQAEKILDTENL 1275
++ L ++++++ S + K + K N+ + + QAE+ L
Sbjct: 1516 KAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQG 1575
Query: 1276 FEAQQLLLHHQQKTKRISAKKRDVQQQ---IAQAQQGEGGLPDRGHEEL--RKLESTLDG 1330
QQ L Q+ + + D+Q + A + G + +L R+L + +
Sbjct: 1576 RTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK 1635
Query: 1331 LERSRERQE----------RRIQVTLRKWERFETNKETVVRYLFQT-------------- 1366
L +++E+ E + ++ + + ET K + L +
Sbjct: 1636 LHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSV 1695
Query: 1367 GSSHERFLS-FSSLESLSS----------------------ELEQTKEFSK-RTESIAVQ 1402
GSS + L+ +E LS +L++ E K R + + Q
Sbjct: 1696 GSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQ 1755
Query: 1403 AENLVKEASEIP---------LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKT 1453
+N + L P+ +Q+LQQ+ +KEQ E ++K ++ ++
Sbjct: 1756 QQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQD 1815
Query: 1454 KWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK--------VTIQEIESKLS 1505
+ F + + W+ EKEL + S+ + S +K V + + +
Sbjct: 1816 ELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFV 1875
Query: 1506 SIVGLE--EEAQSFAQFVTTGESAR-IKAKLTQIRRYGEELREHAQCLE-----GTILGH 1557
+I G + + SF + E +K KL L H++C +LG
Sbjct: 1876 TISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL--HSKCTRLGSHLNMLLGQ 1933
Query: 1558 LSQQQKFEENLRKIQQSVSE-----FEDKLAVPIKICSSATETYKVLQEHMDLCQA-LES 1611
Q Q ++L+ Q+ D +A + T K LQE + Q +E
Sbjct: 1934 YHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEK 1993
Query: 1612 LSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQTALENLLAHWQRLEKE 1670
L + VQE ++ ++ + ER + L+ +A Q +++
Sbjct: 1994 LQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQES 2053
Query: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
L S L + E ++ + V ++ L L+ ++ Q S ++
Sbjct: 2054 LESLLQSIGEVEQNLEGKQVSSLSSGV-IQEALATNMKLKQDIARQKSSLEATREMVTRF 2112
Query: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
A +++ L ++ +R+ L ++ + L+ ++ + + F+ L ++
Sbjct: 2113 METADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN 2172
Query: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDL 1846
++ S Q +I+ Q+ ++ E+E ++ L +L+ + +L S G A DL
Sbjct: 2173 KSRMLASGNQPDQDITHFFQQI-----QELNLEMEDQQENLDTLEHLVTELSSCGFALDL 2227
Query: 1847 HLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
Q + ++ + F E + V+ R+ S E L L ++ + E S+
Sbjct: 2228 CQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLK--ETEGSIPP 2285
Query: 1907 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKI---GSSEQRTSCRATADQLC 1963
E+ + K+L +++ K+L LD SK +I G+S + TA
Sbjct: 2286 TETSMSAKELEKQIEHLKSL------LDDWASKGTLVEEINCKGTSLENLIMEITAPDSQ 2339
Query: 1964 GEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQ 2022
G+ I +G+ + K E+ + D+ + +K + +++LQ
Sbjct: 2340 GKTGSILPSVGSSVGSVNGYHTCK-----DLTEIQCDMSDVNLKYEKLGGVLHERQESLQ 2394
Query: 2023 QRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIH 2082
L ++ E NS L WL+ K + + D +P + ++ + K +
Sbjct: 2395 AILNRMEEVHKEANS---VLQWLESKEEVLKSMDAMSSP---TKTETVKAQAESNKAFLA 2448
Query: 2083 ENQGQCC-------GLIDLMREYQNLKSAVS--KVLENASS--VIVTRTTIKDQEDLK-- 2129
E + L L+ Y N + A + K+ E +S T T+ Q L+
Sbjct: 2449 ELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEES 2508
Query: 2130 ----------------WAFSKH----------------ETAKNKMNYKQKDLDNFTSKGK 2157
W K K ++ + K+ + + +
Sbjct: 2509 ASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHE 2568
Query: 2158 HLLSELKKIHS--SDFSL----VKTDMESTVDKWLDVSEKL---EENMDRLRVSLSIWDD 2208
L + I + D SL V+ +++S KW+++++KL +D+ V + + +
Sbjct: 2569 QLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQE 2628
Query: 2209 VLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2268
+L E V Q S + A + E SE+++ LE+L +V +
Sbjct: 2629 LLQDLSE----KVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSD---LEQLDHEVKEA 2681
Query: 2269 KELTKNLETPPDLQFIEADLMQKLEHA-------KEITEVAKGTLKDFTAQSTQVEKFIN 2321
+ L L Q+++ +L ++LE +++ L+ A + Q ++ +
Sbjct: 2682 QTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFD 2741
Query: 2322 DITTWF-TKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENL-----NSLCR 2375
++ TW K + NC + E L+ +E Q + S + E + + L
Sbjct: 2742 ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLS 2801
Query: 2376 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAK 2433
E +L + L E +S+ + Q+ L++ ++K + +++ W K
Sbjct: 2802 VPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCK 2861
Query: 2434 AAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQ 2493
A E T D LE+ L + +L+ V +S L+ + L + S+ I+
Sbjct: 2862 AKMSELR-VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADIL-INSSEADEDGIR 2919
Query: 2494 EQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT-ENLGE 2552
++ N+ A ++ +L++ L F++ + + + + + + LG
Sbjct: 2920 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALG- 2978
Query: 2553 SKQHIPEKKNEVHKVEMFLGELLAARE-SLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTS 2611
Q K E + + E+L A E +D L Q L E+ +L Q +
Sbjct: 2979 -SQACSNKNLEKLRAQQ---EVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVA 3034
Query: 2612 HQNLLRMTKEKLRSCQVALQEHEALEE---ALQSMWFWVKAIQDRLACAESTLGSKDTLE 2668
Q L + + C + + E + + ++ M+ + + D L + D+L+
Sbjct: 3035 QQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQ 3094
Query: 2669 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQTQLETLKEVWADI 2724
SQI+D+ L + V L + I E R +E + ++ +LE L + +
Sbjct: 3095 ---SQIEDVRLFLNKIHV-LKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKL 3150
Query: 2725 MSSSVHAQSTLESVISQWNDYVERKNQLE------------QWMESVDQKIEHPLQPQPG 2772
Q LE + + D+ + L QW+ + +I +
Sbjct: 3151 TERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3210
Query: 2773 LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIM 2832
+ +K +D LQ L + + L + K ++ D EE+ ++N +
Sbjct: 3211 MFQK-EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHD-------MEEINARWNTLN 3262
Query: 2833 TVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSK--- 2889
+++ +++E + + DA+ WL +E + S + + ++ +
Sbjct: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
Query: 2890 IKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQS 2949
++ L+D R+ + + +++ + Q+ + E + ++++L + W + Q
Sbjct: 3323 LQRLLDDRK---ATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQK 3379
Query: 2950 CLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG 3009
LE++ + L++ Q + E S L ++L E T K
Sbjct: 3380 QLEDI---LVLAK--------QFHETAEPISDFLSVTEKKLANSEPVGTQTA------KI 3422
Query: 3010 QEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYS-----GKVSGLIKEYNCLCLQASKG 3064
Q+ + + E E+ + +++ + + LS+ + G +S I +
Sbjct: 3423 QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482
Query: 3065 CQNKEQILQQRFRKAFR------DFQQWL--VNAKITTAKCFDIPQNI--SEVSTSLQKI 3114
C K +L Q A + WL V K+++ D Q++ + + L
Sbjct: 3483 CCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALN 3542
Query: 3115 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESA 3174
+E ++ +N ++ + G+ L T E+ IQ K+ K + + +
Sbjct: 3543 EEIVNRKKN----VDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRT 3598
Query: 3175 LENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYE 3234
LE + F+ + E + WL + E+ + S + + QQ+ + + +E+ +
Sbjct: 3599 LEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHR 3658
Query: 3235 PQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQF 3292
L+ + E ++ L E A + VS + QY +S+ ++V +D + Q+
Sbjct: 3659 LVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQY 3718
Query: 3293 SLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVK--QEKEIQMKMIVTR 3350
W+ + L + P + + L+++ S+ + K+ ++ R
Sbjct: 3719 EQAADAELAWVAETKRKLMA-LGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 3777
Query: 3351 GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3410
E + E +Q++ +S+ + ++ ++LE A + + + S
Sbjct: 3778 SE-IFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSP 3836
Query: 3411 WMD---SMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI-----EVKGAG 3462
W++ ++ A L H +LR + + + L E + + ++ + ++K
Sbjct: 3837 WIEETRALIAQLPSPAIDHEQLRQQQE---EMRQLRESIAEHKPHIDKLLKIGPQLKELN 3893
Query: 3463 MTEHYVTQLELQDLQERYRAIQERAK-------EAVTKSEKLVRLHQEYQRDLKAFEVWL 3515
E + + + Q + Y I+E + EAV++S ++ H + + L+ E
Sbjct: 3894 PEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLE--- 3950
Query: 3516 GQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE 3575
+L ++ + + D + V + Q ++ E++I +
Sbjct: 3951 -NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADK 4009
Query: 3576 DRALESLRQD-------WQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE-- 3626
D A + ++ W+ + R E +F +V L L E+ + + L T ++
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDV---LELAEKFWYDMAALLTTIKDTQ 4066
Query: 3627 -----------------------KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQ 3663
+ EE +E+E + +++ + +
Sbjct: 4067 DIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVR 4126
Query: 3664 AT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGST---HKNFKNVAT 3718
+ ++ + ++ L E+++ LE+ +Q+ + + +L + DW +T V T
Sbjct: 4127 KSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGT 4186
Query: 3719 KIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAV-KYLEEGEAERLRKEIHD 3777
++ V + K +EV + +E ++ +GE + K +E + + +R+ + +
Sbjct: 4187 DLNTVKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTE 4241
Query: 3778 HMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEK 3837
+ L + LE L +F + L W+ +E+L +
Sbjct: 4242 LKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVI 4301
Query: 3838 KAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE-------------------LVQDVTLK 3878
+ +L+K+ L+ VL+H+ +V++V + G LLE + V K
Sbjct: 4302 EVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQK 4361
Query: 3879 --DKIDQLQSDYQDLCSIGKAMME---EIAGFEDRLNNLQMKG---DTLIGQCADHL--- 3927
++ QLQS Q + + E+ E +L+ + G +T Q H+
Sbjct: 4362 TEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELY 4421
Query: 3928 -QAKLKQNVHAHL---------------QGTKDSYS---------AICSTAQRMYQSLEH 3962
Q K K+ + L G+K S + S + LE
Sbjct: 4422 SQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4481
Query: 3963 ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLL 4022
L Q++LQ+ WL+ + L + P L + Q++ + + + D +
Sbjct: 4482 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQI 4541
Query: 4023 CSMCDLSN-----------ASVKTTAKDIQ-QTEQTIEQKLVQAQNLTQGWEEIKHLK-- 4068
+ N +K +Q + E+ +++ + + ++L + K
Sbjct: 4542 IELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 4601
Query: 4069 -SELWIYLQDADQQLQNMKRRHSELELNIAQNMV----SQVKDFVKKLQSKQASVNTIIE 4123
+L +L+DA+ L SELE++ + + S+ K+F K L KQ +T I
Sbjct: 4602 WKKLIDWLEDAESHLD------SELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
Query: 4124 KVNKLTKKEESPEHKE-----INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4178
L +K PE + + + D+W +C +S + EE L + + D + +
Sbjct: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715
Query: 4179 EVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLN 4236
+L K + D D + ++A K L +R ++ LK +++IE+ +
Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN-S 4774
Query: 4237 LDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4296
DD VK Q L RW + L K L++ V + L+EW E + +
Sbjct: 4775 RDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 4834
Query: 4297 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKAL 4356
+ Q+L+ H ++E K++ + S + + ++A + I+ +
Sbjct: 4835 RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWI 4894
Query: 4357 SDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPD 4416
+ ++ + Q ++ L ALSE + + + IQ E ++ R+ +
Sbjct: 4895 TIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQ-----E 4949
Query: 4417 DVSKQVKTCKSAQASLKTYQNEVT 4440
+ + + K+ A +T+ E+T
Sbjct: 4950 PIPQNIDRVKALIAEHQTFMEEMT 4973
Score = 212 bits (539), Expect = 1e-53
Identities = 504/2757 (18%), Positives = 1054/2757 (38%), Gaps = 332/2757 (12%)
Query: 510 MEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQI 569
+++LE K +L + S K+ E+V+ ++ +F+ EQ Q
Sbjct: 2411 LQWLESKEEVLKSMDAMSSPTKT--------ETVKAQAESNKAFLAE---LEQNSPKIQK 2459
Query: 570 LKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTV 629
+K+ + + +EAEN K E ++W + + + LEE S+ +
Sbjct: 2460 VKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAE 2519
Query: 630 ASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIE 676
+ L+ WL + E MLN + + + QQH +N+A ++
Sbjct: 2520 SQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT 2579
Query: 677 TCDE--MVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEA 734
+ + + ++++L +N +W EL TD + + S+ +A
Sbjct: 2580 GPGDVSLSTSQVQKELQSINQKWVEL--------------------TDKLNSRSSQIDQA 2619
Query: 735 HKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFA 794
K ++ E+ L+D+ ++V + + + ++A E+ +++ +E
Sbjct: 2620 IVKSTQYQEL-----------LQDLSEKVRAVGQRLSV--QSAISTQPEAVKQQLEETSE 2666
Query: 795 TMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQS 854
S L++ +VKE + L + +LI + L+ + L++ ++
Sbjct: 2667 IRSDLEQLDHEVKEAQT--LCDELSVLIGEQYLKDE-----------------LKKRLET 2707
Query: 855 SALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVA 914
AL Q ++L A + N RLQ +A
Sbjct: 2708 VALPLQGLEDLAADRIN-------------------------------RLQAALASTQ-Q 2735
Query: 915 FQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFF 974
FQ M + W + S+ K S A+LE++ Q L+E + ++ L +H+ +
Sbjct: 2736 FQQMFDELRTWLD--DKQSQQAKNCPIS-AKLERL----QSQLQENEEFQKSLNQHSGSY 2788
Query: 975 SQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVE 1034
+ + L + P +E++ LQ + +L W++L + LK ++
Sbjct: 2789 EVI-------VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ 2841
Query: 1035 KNR--------FLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQ 1086
K + + +E+C+ ++ + E + + ++ EKR
Sbjct: 2842 KAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNE------VEKRRS 2895
Query: 1087 LIEEL--CVKLPVRDPVRDTPGTCHVTLKELRAAI----DSTYRKLMEDPDKWKDYTSRF 1140
L+E L + + D G +++ +A I D+ +L ++ T R
Sbjct: 2896 LLEILNSAADILINSSEADEDG-----IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRL 2950
Query: 1141 SEFSSWISTNETQLKGIK---------GEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL 1191
EF E +++G K G + + E RA +E+ + + + +L
Sbjct: 2951 REFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQ---VDYL 3007
Query: 1192 KSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNS 1251
++ + L E + + G + ++L + EV++ +++ CV +++N
Sbjct: 3008 RNFTQGLVEDAPD------GSDASQLLHQAEVAQQEFLEVKQRVNS--GCV----MMENK 3055
Query: 1252 LEELISGSKEVQEQAEKILDTENLFEAQQLL------LHHQQKTKRISAKKRDVQQQIAQ 1305
LE + V+E ++ D ++ + + L Q + R+ K V + +
Sbjct: 3056 LEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIE 3115
Query: 1306 AQQGEGG--LPDRGHEELRKLESTLDGL--------ERSRERQERRIQVTLRKWERFETN 1355
A + E L + G +L L+ L+ L ER + RQE+ +++TL + E F
Sbjct: 3116 ASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ-LELTLGRVEDFYRK 3174
Query: 1356 KETVVRYLFQTGSSHE-RFLSFSSLESLSSELEQTKEFSK--------RTESIAVQAENL 1406
+ + + +++ + +E ++ +L K F K + + + + L
Sbjct: 3175 LKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGL 3234
Query: 1407 VKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLS 1466
++ A + + Q L+ + I + L + + I ++ F E L
Sbjct: 3235 IQSAGK----DCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLL 3290
Query: 1467 VWITEKEKELNALETSSSA----MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVT 1522
W+ + E EL A + SA + QI + K+ + ++ + +++ L+ E AQ
Sbjct: 3291 SWLADTE-ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAE 3349
Query: 1523 TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKL 1582
+ +I +L + EL A + + L ++F E I +S E KL
Sbjct: 3350 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3409
Query: 1583 AVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAA----- 1637
A + + + + + H L + +E+ ++ + + + + S ++
Sbjct: 3410 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3469
Query: 1638 -ALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEM-DISAD 1695
+LQ +Y +I R + L+ L++ + ++ L WL E K SS + D D
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529
Query: 1696 RVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755
+ + L AL E+V++ + ++ ++L + ++V +++ L+ + R+ D
Sbjct: 3530 VLHRQHADHL--ALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYAD 3587
Query: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVA--LTRH 1813
+ +K + L+ +F + W++ EL T+ S Q+ R
Sbjct: 3588 ITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQ 3647
Query: 1814 KDHAAEVESKK---GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA-SQVVER 1869
K+ EV + + + L +L E L L A + ++L + Q V+
Sbjct: 3648 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
Query: 1870 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDA-LQNAKALES 1928
A+ ++ Q+ + + + ++ + A + +E+D A LQ KA
Sbjct: 3708 IDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR------LEQDQTTAQLQVQKAFSI 3761
Query: 1929 AAV----SLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALA 1984
+ S+D + S EQ+T + + L + E I L + + +
Sbjct: 3762 DIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQ 3821
Query: 1985 VLKKAFQDQKEELLKSIEDIEERTDKERLKEPT--RQALQQRLRVFNQLEDELNSHEHEL 2042
VL F + EEL IE E R +L P + L+Q+ QL + + H+ +
Sbjct: 3822 VLVNQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 3879
Query: 2043 CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ---GQCCGLIDLMREYQ 2099
L Q+ + + V+ + + E + K + + + + E+
Sbjct: 3880 DKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFH 3939
Query: 2100 NLKSAVSKVLENASSVIVTRTTIKDQED-LKWAFSKHETAKNKMNYKQKDLDNFTSKGKH 2158
+ + + LEN SS + I + D ++ S +++A ++ Q + +G+
Sbjct: 3940 DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 3999
Query: 2159 LLSELKKIHSSDFSLVKTDMESTVDK----WLDVSEKLEEN----MDRLRVSLSIWDDVL 2210
L+ + +D L +++ +D+ W D+ + EE +D L ++ W D+
Sbjct: 4000 LIG---RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMA 4056
Query: 2211 STRDEIEGWSNNCVPQMAENI--SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDL 2268
+ I+ + + I S + + A E +KE E LE + DL
Sbjct: 4057 ALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE---ETDGLHEELEFIRILGADL 4113
Query: 2269 KELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFT 2328
E P + I+ ++ E+ + + L+D + Q + + + W
Sbjct: 4114 IFACGETEKPEVRKSID-EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLD 4172
Query: 2329 KVEESL-----MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRK-YHSAEL 2382
L + N + L ++K+ + E+ QQ + + +K +
Sbjct: 4173 NTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDR 4232
Query: 2383 ESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK--HFSESMQEFQEWFLGAKAAAKESS 2440
+ + +T L E + + + Q L+ +L F +++E W +
Sbjct: 4233 DIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQR 4292
Query: 2441 DRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKAN 2500
+GD KV+E +L + + V Q+ ++ V + G L + SS++ ++ N
Sbjct: 4293 PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMN 4352
Query: 2501 EEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK 2560
+ +++ L++ + +Q LQ + F + L + ME + + + +PE
Sbjct: 4353 QCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSA---SKPTGGLPET 4409
Query: 2561 KNEVHKVEMFL-GELLAARESLDKLSQRGQ--LLSEEGHGAGQEGRLCSQLLTSHQNLLR 2617
E M L +L A E+ ++L +G+ LLS + G+G + LL +++
Sbjct: 4410 AREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVS 4469
Query: 2618 MTKEKLRS-CQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
E+ +S + AL + +LQ W+ + L A +T+ LSQI++
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTV---LSQIEE 4526
Query: 2677 ILLMKGEGEVKLNMAI---GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQS 2733
+ E + I G Q S K+ +I+ L +++ W ++ S+
Sbjct: 4527 HKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGR 4586
Query: 2734 TLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDH 2793
+L+ + + E +L W+E + ++ L+ + + L +
Sbjct: 4587 SLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGK 4646
Query: 2794 TRALHRLIAKSRELYEKT---EDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL 2850
I R L EKT ED D E++ +++ + + E+ K+EE +
Sbjct: 4647 QPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSG 4706
Query: 2851 MYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESL 2910
++DA+ DWL+ + +L + GD L + L+D+ ++ L +
Sbjct: 4707 QFMDALQALVDWLYKVEPQLAEDQPVHGD-------LDLVMNLMDAHKVFQKELGKRTGT 4759
Query: 2911 APEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA 2970
+K+ SG EL+ D W Q S + V ++++S+Q +
Sbjct: 4760 VQVLKR----SGRELIENS-----RDDTTWVKGQLQELSTRWDTVCKLSVSKQ------S 4804
Query: 2971 QLEQALEQFSA------LLKTW---AQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEP 3021
+LEQAL+Q +L W A+Q G D+ Q ++D ++
Sbjct: 4805 RLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDT-----EALQSLIDTHKEFMK 4859
Query: 3022 RTEDLKSQLNELCRFSR---------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
+ E+ + +N ++T ++ + + + A + Q E L
Sbjct: 4860 KVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL 4919
Query: 3073 QQRFRKA--FRDFQQWLVNAKITTAKCFD--IPQNISEVSTSLQKIQEFLSESENGQ 3125
+ A + W+ A+ T + IPQNI V + + Q F+ E Q
Sbjct: 4920 SELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQ 4976
Score = 211 bits (538), Expect = 2e-53
Identities = 155/457 (33%), Positives = 233/457 (50%), Gaps = 77/457 (16%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKW+N HL K + ++DL+ED++DG L++LLEVLSG KLP E+
Sbjct: 71 RVADERDRVQKKTFTKWVNKHLMKVRKH--INDLYEDLRDGHNLISLLEVLSGIKLPREK 128
Query: 80 GRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILY 139
GR R H + N+ AL FL+ R+ +KLVNI + DI DG P + LGL+WTIIL+
Sbjct: 129 GRM--RFHRLQNVQIALDFLKQRQ-------VKLVNIRNDDITDGNPKLTLGLIWTIILH 179
Query: 140 FQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTA 199
FQI ++ +S E+ +K K LL W Q
Sbjct: 180 FQISDI-------------------YISGESGDMSAKEK------------LLLWTQKVT 208
Query: 200 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 259
TGI+ +F W G F+++IH RP+LVD+E V+ +SNRENLE AF +AE LG+
Sbjct: 209 AGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAE-RLGV 267
Query: 260 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 319
RLLD EDVDV PDEKS++TYV+ +P + +G E+ + + + V +
Sbjct: 268 TRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGG-EGISATEVDSRWQEYQSRVDS- 325
Query: 320 KREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDK--YQSFKHFR----VQYEMKRKQIE 373
+ WI+Q ++ ++ ++ K Y + HF+ + E ++ +IE
Sbjct: 326 ----------LIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIE 375
Query: 374 HLIQPLH---RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSL-PAPLGTIGAWLYRAE 429
L + L G++ L Q + +L ++ +KSL PA + R E
Sbjct: 376 ELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPA--------VERLE 427
Query: 430 VALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAH 466
+ L+ +Q A + KL K+ LQ AH
Sbjct: 428 LLLQIANKIQ----NGALNCEEKLTLAKNTLQADAAH 460
Score = 159 bits (401), Expect = 2e-37
Identities = 465/2549 (18%), Positives = 965/2549 (37%), Gaps = 373/2549 (14%)
Query: 6295 SSQSGGAKRQSIHLEQKLYDGVSATST-WLD-----DVEERLFVATALLPEETETCLFNQ 6348
SS S R ++L + D V ST +L+ DV R LL + E L +
Sbjct: 1124 SSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQE 1183
Query: 6349 EILAKDIKEMSEEMD---------KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDS 6399
E++ D+ + K+KN E V+ + + L +L
Sbjct: 1184 EVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLE 1243
Query: 6400 VVNQRCHQMKERLQQILNF----QNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAI 6455
++ Q++ER +++ Q++L+ + L D + + + E +++
Sbjct: 1244 RYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKP 1303
Query: 6456 QQAEDG------LKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSG 6509
QAED L + A E++R KL Q Q+ S
Sbjct: 1304 GQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYS------------------- 1344
Query: 6510 LNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEI-QQLLDKHKEYFQGLES 6568
T+ YE L +E+ Q+K G ++ ++SS + I Q+ +D Y +
Sbjct: 1345 -----TIVKDYELQLMTYKAFVES-QQKSPGKRRRMLSSSDAITQEFMDLRTRY-----T 1393
Query: 6569 HMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW-SHLDEDQ 6627
++ T K IS A+++ + + V++ + VE L W S L +
Sbjct: 1394 ALVTLTTQHVKYISDALRR--------LEEEEKVVEEEKQEHVEKVKELLGWVSTLARNT 1445
Query: 6628 QELSRQLEVVESSIPSVGLVEE---NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6684
Q + E ES+ ++E+ +E+ + + + +K+S +++ + K+
Sbjct: 1446 QGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKK 1505
Query: 6685 LLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS----------ESA 6734
+ QLN L + + + + +L +L++ L H T ++ +
Sbjct: 1506 --------QISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLE 1557
Query: 6735 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6794
DL W+ A+ L Q T Q+L ++ + + + ++ +++ ++V+
Sbjct: 1558 DLCSWVGQAERALA--GHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEG 1615
Query: 6795 LL-----RLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ-----LQMDKLPSRHA 6844
+ +L + LR +L + Q+ L Q++L + LQ + S+ A
Sbjct: 1616 FMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA 1675
Query: 6845 ---------ISEVMSWIS--------LMENV--------IQKDEDNIKNSIGYKAIHEYL 6879
I ++ W++ L+ N+ ++ + + GY +++
Sbjct: 1676 KELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAP 1735
Query: 6880 QKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 6939
+K +D C+ + +Q +L + + +S + F +Q G L
Sbjct: 1736 EK-----LDKQCEMMKAR--HQELLSQQQNFILATQSAQA-FLDQHG---------HNLT 1778
Query: 6940 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 6999
E+ Q+L+ L E + T E LKQ + D+ +Q L+D ++ E
Sbjct: 1779 PEEQQMLQQKLGELKEQYS------TSLAQSEAELKQVQTLQDE--LQKFLQDHKEFESW 1830
Query: 7000 IKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLD 7059
++ EKE+E + + G + + S L+ G S +
Sbjct: 1831 LERSEKELENMHKGGSS---------PETLPSLLKRQG------------------SFSE 1863
Query: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKF 7119
SHK G L V + + ++++ K+ + +
Sbjct: 1864 DVISHK------------------------GDLRFVTISGQKVLDMENSF-KEGKEPSEI 1898
Query: 7120 GSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQ 7179
G++ LK+ T L + + N LL + Q Q+S LQ W +
Sbjct: 1899 GNLVKDKLKDATERYT-ALHSKCTRLGSHLNMLLGQY-HQFQNSADSLQAWMQ------A 1950
Query: 7180 CASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQL 7239
C + V++ T A++ + +++AT Q +L + V+ ++ E
Sbjct: 1951 CEANVEKLLSDT-----VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI- 2004
Query: 7240 KQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVE 7299
+ A +Q S+ H +L +L ++ + LQ + ++ +SLE+L I E
Sbjct: 2005 -EGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063
Query: 7300 AEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK-- 7357
E+ L+G+ S S IQE + + L+ E+ R
Sbjct: 2064 VEQNLEGKQVSSLSS-GVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA 2122
Query: 7358 ----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEIS 7413
++ +++ + + Q E+ S L+ L Q + F +F+ + LA S
Sbjct: 2123 VLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA---S 2179
Query: 7414 GNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTL 7468
GN H +Q + L EM +Q+ L ++ L G D + ++
Sbjct: 2180 GNQPDQDITHFFQQIQELNL---EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236
Query: 7469 LSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP--- 7525
L + + + ++R S Q +R++ +KWL E GS+P
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETE-------GSIPPTETS 2289
Query: 7526 ---------LQQARTLFDEVQFK----EKVFLRQQGSYILTVEA------GK--QLLLSA 7564
++ ++L D+ K E++ + L +E GK +L S
Sbjct: 2290 MSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSV 2349
Query: 7565 DSGAEAA-----------LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD 7613
S + +Q +++++ K++ L E+++ L +L E+ K
Sbjct: 2350 GSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANS 2409
Query: 7614 SLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENA--VGSWTDDLTQLSLLKDTLSA-- 7669
L+ L + K+++ +S+ E ++ + N + + ++ +K+ L+
Sbjct: 2410 VLQWLES-KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL 2468
Query: 7670 --YISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQ 7727
Y ++ + + E L +WE R++Q+ E + A F +L WL +
Sbjct: 2469 VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLME 2528
Query: 7728 MESKVSQNGDILIE-EMIEKLKKDYQEEIAIAQENKIQLQQMGERL-----AKASHESKA 7781
E + G + I+ M+ K+ Q + + + Q +Q+ E
Sbjct: 2529 KELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLST 2588
Query: 7782 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPI 7841
S+++ +L +N +W L D + +R ++ + +V Q + + L + + L+
Sbjct: 2589 SQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQS 2648
Query: 7842 VYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQA 7901
S E ++++L E E++ D+E+ V LC+ L D +++
Sbjct: 2649 AI-STQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDEL---SVLIGEQYLKDELKKR 2704
Query: 7902 TRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGV 7959
+ + + ++ +R +++ Q+F + WL K S++ P S+ +
Sbjct: 2705 LETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKL 2764
Query: 7960 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL------ARENRTDSACSLKQMVHE 8013
+ +L++ E FQ+ +++ E+I + L E RT L+ + E
Sbjct: 2765 --ERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT-----LQNQLVE 2817
Query: 8014 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDVQ 8072
W+ L K+ RLK + + ++++ + ++ W+ + +++ + ++
Sbjct: 2818 LKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLE 2877
Query: 8073 AKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAI------IEEELDELRRYCQ 8126
+ + + KA E+ + +E + + + LI SE + I I + +D + Q
Sbjct: 2878 SSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQ 2937
Query: 8127 EVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNL 8186
G +E ++L E S + +E + A L D L Q SN
Sbjct: 2938 AKTGSLEEMTQRL-------REFQESFKNIEKKVEGAKHQLEIFDA-----LGSQACSNK 2985
Query: 8187 SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246
+L + LR+++ LE DY + ++ L + +G D
Sbjct: 2986 NL---EKLRAQQEVLQA--------LEPQVDYLRN------FTQGLVEDAPDGSDASQLL 3028
Query: 8247 LRGAVGLSDVM-IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD--DSRFQIQQ 8303
+ V + + + + + + EN ++ H + QL D D I +
Sbjct: 3029 HQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGR 3088
Query: 8304 TENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTE 8363
+ ++S+ L + +KL E S + H L+EE G ++L +
Sbjct: 3089 DTDSLQSQIED-VRLFLNKIHVLKLDIEASEA-----ECRHMLEEE-----GTLDLLGLK 3137
Query: 8364 TQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE- 8422
+ + + L + +++ +++ L + + F L L D E+ + L+
Sbjct: 3138 RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQW 3193
Query: 8423 -LSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQADSKES--RDLQDRLSQ 8478
+ T+++ I Q+ K QK VD + + +N Q+ K+ + L+ + +
Sbjct: 3194 VVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253
Query: 8479 MNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAE 8538
+N RW+ + + + LQ+AL+ C F + LL L + + P +
Sbjct: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313
Query: 8539 ILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLL 8598
Q ++L+Q L + + V LQ ++ +AE D + ++ + +R LL
Sbjct: 3314 KAQIQEQKLLQ--RLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELL 3371
Query: 8599 KEVSRHIKELEKLLDVS----SSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGK 8654
+ + K+LE +L ++ + + +S + S E + S P ++ +Q+ R K
Sbjct: 3372 SKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANS-EPVGTQTAKIQQQIIRHK 3430
Query: 8655 CSLSQPGPSVSSPHSRSTKGGSDSSLSEP 8683
+ H G S SSL+ P
Sbjct: 3431 ALEEDIENHATDVHQAVKIGQSLSSLTSP 3459
Score = 154 bits (389), Expect = 4e-36
Identities = 445/2581 (17%), Positives = 976/2581 (37%), Gaps = 297/2581 (11%)
Query: 351 LQDKYQSFKHFRVQYEMKRKQIEHLIQP----LHRDGKLSLDQALVK-------QSWDRV 399
L + Q + ++E +R+Q E L + L G +SL + V+ Q W +
Sbjct: 2546 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 2605
Query: 400 TSRLFDWHIQLDKSL--PAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHK 457
T +L Q+D+++ + L A+ + ++VQ ++++LE+
Sbjct: 2606 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
Query: 458 DLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKY 517
++ + + E + + L+D ++ T L L +E L
Sbjct: 2666 EIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR---LETVALPLQGLEDLAADR 2722
Query: 518 --RLLSLLVLAES------KLKSWIIKYGRRES--------VEQLLQNYVSFIENSKFFE 561
RL + L + +L++W+ +++ +E+L E K
Sbjct: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782
Query: 562 QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISN 621
Q+ +Y+++ E + + EE + + E W LS + +S L++ +
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 2842
Query: 622 WDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEM 681
+Y V L W+ED + AK R +Q +++ + L E
Sbjct: 2843 AQKYQWHVEDLVPWIEDCK--------AKMSELRVTLDPVQLESSLLRSKAMLNEV---- 2890
Query: 682 VSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEP 741
+ ++ LL + ++ + ++ADE D ++ E + A E K
Sbjct: 2891 ---EKRRSLLEILNSAADILI---NSSEADE-DGIRDEKAGINQNMDAVTEELQAKTG-- 2941
Query: 742 LEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKE 801
LE++ QR+ +K I K E K L
Sbjct: 2942 -------------SLEEMTQRLREFQESFKNIEKKV---------EGAKHQLEIFDALGS 2979
Query: 802 QLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQ- 860
Q K L Q++L LE + +F L + + +S L Q
Sbjct: 2980 QACSNKNLEK--LRAQQEVLQALEPQVDYLRNFTQGL------VEDAPDGSDASQLLHQA 3031
Query: 861 --KHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSM 918
QE L ++ ++E + + +F H + Q+AD+ M
Sbjct: 3032 EVAQQEFLEVKQRVNSGCVMMENKLEGIGQF--------HCRVREMFSQLADLDDELDGM 3083
Query: 919 ---VKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 975
+ T + +E + K + ++E + LEE+G + L +
Sbjct: 3084 GAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK------ 3137
Query: 976 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEK 1035
R L A K C +LT+ + Q+ L+ + ++ ++ L+G L E+
Sbjct: 3138 ----RELEALNKQCGKLTE-RGKARQEQLELTLGRVEDFYRKLKG-----LNDATTAAEE 3187
Query: 1036 NRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKL 1095
L V E+ + Q K+ ++ +V P + +++ + + ++
Sbjct: 3188 AEALQWVVGTEVEI-----INQQLADFKMFQKEQV-----DPLQMKLQQVNGLGQGLIQS 3237
Query: 1096 PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS-------SWIS 1148
+D D G H ++E+ A ++ +K+ + + ++ +F SW++
Sbjct: 3238 AGKD--CDVQGLEH-DMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLA 3294
Query: 1149 TNETQLKGIKGEAIDTANHGEVKRAVEE---IRNGVTKRGETLSWLKSRLKVLTEVSSEN 1205
E + I + +A + VK ++E ++ + R T+ L++ + + +
Sbjct: 3295 DTE---ELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELA 3351
Query: 1206 EAQKQGDELAKLSSSFKALVTLLSEVEKMLSN-------FGDCVQYKEIVKNSLEELISG 1258
+ +K +L L S + L++ + +K L + F + + + E+ ++
Sbjct: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3411
Query: 1259 SKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQ--QIAQAQQGEGGLPDR 1316
S+ V Q KI QQ ++ H+ + I DV Q +I Q+ ++
Sbjct: 3412 SEPVGTQTAKI---------QQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQ 3462
Query: 1317 G--HEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFL 1374
G E++ L++ ++ R+ + L F ++ V+ +L + E L
Sbjct: 3463 GVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEV----EDKL 3518
Query: 1375 SFSSLESLSSEL--EQTKEFSKRTESIAVQAENL---VKEASEIPLGPQNKQ--LLQQQA 1427
S ++ ++ Q + E I + +N+ +K + ++ L+Q++
Sbjct: 3519 SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKL 3578
Query: 1428 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1487
IK + + T + ++T+E + F S +E L+ W+ E E+EL A S
Sbjct: 3579 DGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL-ATSGGQSPTG 3637
Query: 1488 MQISQIKVTIQEIESKLSS----IVGLEEEAQSFAQFV----TTGESARIKAKLTQIRRY 1539
QI Q + +E++ ++ + + E +++ + V G + Q +
Sbjct: 3638 EQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLV 3697
Query: 1540 GEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV--PIKICSSATETYK 1597
+ + + ++ I + Q++E+ V+E + KL PI++ T
Sbjct: 3698 SDTIGQRVDEIDAAI----QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQL 3753
Query: 1598 VLQE--------HMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRR 1649
+Q+ H D L S S I +K V + ++ +L QQYE I
Sbjct: 3754 QVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQ----EKTESLIQQYEAISLL 3809
Query: 1650 AKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA-DRVKVEGELQLIQA 1708
ER LE + + W+E E +A ++ A D ++ + + ++
Sbjct: 3810 NSERYARLERAQVLVNQFWETYEELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQ 3867
Query: 1709 LQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1768
L+ + KLL++ L + + ++ +M++ ++ + + + + + +R L
Sbjct: 3868 LRESIAEHKPHIDKLLKIGPQLKEL-NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALD 3926
Query: 1769 SVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV---------ALTRHKDHAAE 1819
V++ Q E F I+ L L+ S M + ++ +K E
Sbjct: 3927 EAVSQSTQITE----FHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVE 3982
Query: 1820 VESKKGELQSLQGHLAKLGSLGRAEDLHL----LQGKAEDCFQLFEEASQVVERRQLALS 1875
+E + ++L+ +L + D L +Q K + +E+ E R++
Sbjct: 3983 LEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL 4042
Query: 1876 HLAEFLQSH-ASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1934
+ E + ++ +L ++ T + + + ES I+ + Q +A E+ D
Sbjct: 4043 DVLELAEKFWYDMAALLTTIKDTQDIVHDL---ESPGIDPSI--IKQQVEAAETIKEETD 4097
Query: 1935 GILSKAQYHLKIGS-------SEQRTSCRATADQLCGE--------VERIQNLLGTKQSE 1979
G+ + ++ +G+ ++ R + D++ ER++ L Q+
Sbjct: 4098 GLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAA 4157
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVF-NQLEDELNSH 2038
L+ F ++K TD +K+ + + ++ V+ Q+E E +H
Sbjct: 4158 VQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNH 4217
Query: 2039 EHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREY 2098
+ EL + KA +D+ P + L+ W++ I Q + G + + ++
Sbjct: 4218 QGEL--MLKKATDETDRDIIREP-----LTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
Query: 2099 QNLKSAVSKVLENASSVIVTRTTIK-DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGK 2157
Q+ + L + ++ + I D + ++ +KH KN + Q ++ G
Sbjct: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330
Query: 2158 HLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE 2217
L L+ D S +++ +E+ W V +K EE +L+ ST + +
Sbjct: 4331 EL---LESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQ----------STLQQAQ 4377
Query: 2218 GWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLET 2277
G+ + + E ++ +++ L A + + + EL+S++ +E L
Sbjct: 4378 GFHSEIEDFLLE-LTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLD 4436
Query: 2278 PPDLQFIEAD--------------LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDI 2323
L + D L QK E K L++ +T+ + + +
Sbjct: 4437 KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEF 4496
Query: 2324 TTWFTKVEESLMNCAQ------NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2377
W T E+SL N A N +++ K E+ + + I + N L
Sbjct: 4497 INWLTLAEQSL-NIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLS 4555
Query: 2378 HSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWFLGAKAA 2435
++ + + + + E V Q + SL ++ + K F E+ ++ +W A++
Sbjct: 4556 QKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESH 4615
Query: 2436 AKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAH-LSKQIVSSIQE 2494
+ + D ++ +L + ++ Q D + G+ L L + +
Sbjct: 4616 LDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDN 4675
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
+ + +++ + ++ + L++ G F D + L W++++E + +
Sbjct: 4676 FLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGD 4735
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHG--AGQEGRLCSQLLTSH 2612
+ + HKV F EL ++ L + G+ L E +G+L +L T
Sbjct: 4736 LDLVMNLMDAHKV--FQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRW 4792
Query: 2613 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLS 2672
+ +++ K + AL++ E + + + W+ + L + + L+ +
Sbjct: 4793 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 4852
Query: 2673 QIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQ 2732
++ + E V +N A+ GE L + + I+ + ++ + ++++ + Q
Sbjct: 4853 THKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQ 4912
Query: 2733 STLESVISQWNDYVERKNQLEQWME----SVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
LE+ +S+ E +L W++ ++ Q+ + P+ PQ + K ++ +H Q+ +
Sbjct: 4913 QRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPI-PQNIDRVKALIAEH-QTFME 4970
Query: 2789 E 2789
E
Sbjct: 4971 E 4971
Score = 128 bits (322), Expect = 2e-28
Identities = 348/1922 (18%), Positives = 743/1922 (38%), Gaps = 191/1922 (9%)
Query: 488 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 545
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 3146 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3204
Query: 546 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 605
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 3205 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3262
Query: 606 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDF---------FRN 656
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 3263 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3322
Query: 657 LPHWIQQHTAMND----AGNFLIETCDEMVSRDLKQQLLLLNGRWRELFME-VKQYAQAD 711
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 3323 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3382
Query: 712 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 765
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 3383 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3442
Query: 766 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 823
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 3443 VHQAVKIGQSLSSL---TSPAEQG-VLSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3496
Query: 824 LEELEKQMTSFYDSLGKI-NEIITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 879
+ + L ++ +++ +V ++ + L +Q H + LA E N KK +
Sbjct: 3497 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 3555
Query: 880 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 939
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 3556 IKNGQALLKQTTGEEVL------LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 3609
Query: 940 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 990
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 3610 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 3669
Query: 991 ELTDILPEQEQQGLQEAVRKLHKQWK---DLQGEAPYHL---------------LHLKID 1032
L +++P + ++GL + V ++Q+K D G+ + L
Sbjct: 3670 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 3729
Query: 1033 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1085
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 3730 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 3789
Query: 1086 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDS-TYRKLMEDPDKWKDYTSRFSEFS 1144
+++E L + E + ++S Y +L + + E S
Sbjct: 3790 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 3835
Query: 1145 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS- 1203
WI + + AID H ++++ EE+R E + LK+ ++
Sbjct: 3836 PWIEETRALIAQLPSPAID---HEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKEL 3892
Query: 1204 --------ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
E + QK + A++ + L E + + E + +LE L
Sbjct: 3893 NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL 3952
Query: 1256 ISGSKE---VQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGG 1312
S + + + +KI E + + + + ++ A KR ++ I ++Q +
Sbjct: 3953 SSRLRMPPLIPAEVDKI--RECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4010
Query: 1313 LPDRG-HEELRKLESTLDGLERSRERQERRIQVTLRKWERF--------ETNKET--VVR 1361
L + ++L ++ + ++ E +E + L E+F T K+T +V
Sbjct: 4011 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4070
Query: 1362 YLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQ 1421
L G + + +E+ + E+T + E I + +L+ E K
Sbjct: 4071 DLESPGI--DPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKS 4128
Query: 1422 L------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKE 1475
+ + K+ KE+++KLED ++ ++ + ++ +D + L
Sbjct: 4129 IDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCT-------- 4180
Query: 1476 LNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKL 1533
+ + T + + Q++++K E+ + + L + + + T E+ R I+ L
Sbjct: 4181 MPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK-KATDETDRDIIREPL 4239
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
T+++ E L E + + G L +F+ L ++ ++ E+ L I
Sbjct: 4240 TELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPK 4299
Query: 1594 ETYKVLQEHMDLCQALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDIL 1647
L +H L + + + + + + +++ + S A+ Q +E +L
Sbjct: 4300 VIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVL 4359
Query: 1648 RRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1707
++ +ER+ L++ L Q E+ FL L R E++ S+ + E +L
Sbjct: 4360 QKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE-QLDTHM 4418
Query: 1708 ALQNEVVSQASFYSKLLQLKESLFSVASKDDV---KMMKLHLEQLDERWRDLPQIINKRI 1764
L +++ ++ Y++LL + + S+DD + + L+++W + + +R
Sbjct: 4419 ELYSQLKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERK 4476
Query: 1765 NFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV--ALTRHKDHAAEVES 1822
+ L+ + +F L F W+ L L S S++ + V + HK A EV +
Sbjct: 4477 SKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNA 4536
Query: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQ-VVER-RQL--ALSHLA 1878
+ ++ L +L L + +D+ L++ +E+ Q +ER R L A
Sbjct: 4537 HRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAK 4596
Query: 1879 EFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILS 1938
+F ++ L L +++ ++ N+ D I+ L+ + K L D +
Sbjct: 4597 QFHEAWKKLIDWLEDAESHLDSELEIS-NDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 4655
Query: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEV-ERIQNLLG---TKQSEADALAVLKKAFQDQK 1994
+ LK + S + D GEV ++ + G +Q + + + F D
Sbjct: 4656 TGR-ALKEKTLLPEDSQK--LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 4712
Query: 1995 EELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ 2054
+ L+ + +E + +++ + + + EL + LK +++ +
Sbjct: 4713 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 4772
Query: 2055 KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
V ++ L WD +L Q + + +++ + + L A
Sbjct: 4773 NSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQ 4832
Query: 2115 VIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSL 2173
+ R + D E L+ H+ K+ K+ D+++ + G+ +L+ H +
Sbjct: 4833 TLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILA---VCHPDCITT 4889
Query: 2174 VKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW----SNNCVPQMAE 2229
+K + ++ +V +++ RL +LS +E+ W + + E
Sbjct: 4890 IKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQE 4949
Query: 2230 NI-SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELT-----KNLETPPDLQF 2283
I N+D R + L+ E ++ +EE+ K D+ +T KN+E P F
Sbjct: 4950 PIPQNID---RVKALIAEHQT-------FMEEMTRKQPDVDRVTKTYKRKNIE-PTHAPF 4998
Query: 2284 IE 2285
IE
Sbjct: 4999 IE 5000
Score = 113 bits (282), Expect = 9e-24
Identities = 397/2299 (17%), Positives = 889/2299 (38%), Gaps = 363/2299 (15%)
Query: 6516 LKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLL------DKH----KEYFQG 6565
L++ YE LQD D + ++ + + K Q L+ DK K Y
Sbjct: 993 LQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISE 1052
Query: 6566 LESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDE 6625
L++ + E ++++ +Q T+ A L+ A + H E
Sbjct: 1053 LKNIRLRLEEYEQRVVK-RIQSLASSRTDRDAWQDNALRIAEQE------------HTQE 1099
Query: 6626 DQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRL 6685
D Q+L L+ V S + + L+S LN K+ V
Sbjct: 1100 DLQQLRSDLDAVSMKCDSFLHQSPSSSSV-------PTLRSELNLLVEKMDHVYGLSTVY 1152
Query: 6686 LISISCSDLESQLNQLGECWLSNTN-KMSKELHRLETILKHWTRYQSESADLIHWLQSAK 6744
L + D+ + Q E + K+S+E E +L + ++ + L HWL K
Sbjct: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQE----EVVLADLSALEAHWSTLRHWLSDVK 1208
Query: 6745 DRLEFWT--------------QQSVTVPQ---ELEMVRDHLNAFLEFSKEVDAQSSLKSS 6787
D+ ++ Q S P+ +LE ++ + E V AQ ++ S
Sbjct: 1209 DKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQS 1268
Query: 6788 VLSTGNQLLR---------LKKVDTATLRSE------------LSRIDSQWTDLLTNIPA 6826
L + ++L +K ++ T + E LS SQ T L I
Sbjct: 1269 ELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIER 1328
Query: 6827 VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFK 6886
Q KL Q Q S + I KD + + YKA E QK G +
Sbjct: 1329 NQTKLDQCQK---------------FSQQYSTIVKDYE--LQLMTYKAFVESQQKSPGKR 1371
Query: 6887 IDI--NCKQLTVDFVN-----QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV 6939
+ + +T +F++ +++ +++Q V+ ++ L + + ++++
Sbjct: 1372 RRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKY-------ISDALRRLEEEEKVVEEEK 1424
Query: 6940 TEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDL 6999
E ++ ++ LL S N Q T ET+E ++ A+ + Q L +
Sbjct: 1425 QEHVEKVKELLGWVSTLARNTQGKATSSETKES-----------TDIEKAILEQQVLSEE 1473
Query: 7000 IKAKEKEVEK--------IEQNGLALIQNKKEDVSS-----------IVMSTLRELGQTW 7040
+ K+++V + + ++G L + +K+ +S + + +L Q
Sbjct: 1474 LTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ 1533
Query: 7041 ANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS--RFRLLTGSLEAVQVQ 7098
+ L H Q K++ Q ++ + + S++ +A +L+ + R L A+Q
Sbjct: 1534 SQLAHQTEQ-----KTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN 1588
Query: 7099 VDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAE 7158
+L++LQDD++ + S ++E ++ L+E L + E
Sbjct: 1589 QSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREK-------LHQAKE 1641
Query: 7159 QLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDL 7218
Q ++ + ++ Q K+ + S +QQ+ +++ + A NK D + D
Sbjct: 1642 QYEALQEETRVAQ--KELEEAVTSALQQETEKSKAAKELAENKKKIDALL--------DW 1691
Query: 7219 LKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQA 7278
+ +G+ L EQL A + ++Q L++ + Q
Sbjct: 1692 VTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQE 1751
Query: 7279 GVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPD 7338
+ + F + ++ +A++ + L ++ +Q+++ ELK Q
Sbjct: 1752 LLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ------MLQQKLGELKEQY--------- 1796
Query: 7339 LDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWM 7398
L ++ E+K++Q L +LQ FL H+ F E+W+
Sbjct: 1797 -------STSLAQSEAELKQVQTLQ--------------DELQKFLQDHKEF----ESWL 1831
Query: 7399 EFLVQTEQKLAVEISGNYQ-----HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ 7453
E ++E++L G LL++Q + F ++ S + L + I GQ++L+
Sbjct: 1832 E---RSEKELENMHKGGSSPETLPSLLKRQGS---FSEDVISHKGDLRFVTISGQKVLDM 1885
Query: 7454 GQV-----DDRDEFNL---KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7505
+ + NL KL + ++ + + + ++ + Q+ +++ A+ L+
Sbjct: 1886 ENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQ 1945
Query: 7506 KWL----VEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLL 7561
W+ V L + S P LQ+ L Q +E++ Q L A +
Sbjct: 1946 AWMQACEANVEKLLSDTVASDPGVLQEQ--LATTKQLQEELAEHQVPVEKLQKVARDIME 2003
Query: 7562 LSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRT 7620
+ + + +Q I ++S S L E+ L + + ++ + L+ +
Sbjct: 2004 IEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063
Query: 7621 FK-----KKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7675
+ K++S +E A M+ K+ + L ++ ++ ++ D
Sbjct: 2064 VEQNLEGKQVSSLSSGVIQEALATNMKLKQ------DIARQKSSLEATREMVTRFMETAD 2117
Query: 7676 ---ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKV 7732
++L ++ + +++E+LC Q + + + L + +F + +L +++ + +S++
Sbjct: 2118 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFM-ENKSRM 2176
Query: 7733 SQNGDILIEEMIEKLKK--DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGK 7790
+G+ +++ ++ + E+ QEN L+ + L+ + + ++
Sbjct: 2177 LASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2236
Query: 7791 VNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEE 7850
+ + L + R K + + K + + + WL E + P S +++E
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSI--PPTETSMSAKE 2294
Query: 7851 IQRKLNEQQELQRD-------IEKHSTGVASVLNLC-EVLLHDCDACA------------ 7890
+++++ + L D +E+ + S+ NL E+ D
Sbjct: 2295 LEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVG 2354
Query: 7891 ------TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 7944
T + IQ +++ ++ + + ER+ ++ ++ + + WL
Sbjct: 2355 SVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWL 2414
Query: 7945 KSSERT--AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRL-ARENRT 8001
+S E + SS K + + +AF ++ + +++ + + L +
Sbjct: 2415 ESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNS 2474
Query: 8002 DSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL- 8060
A + K++ E N RW+ + + R+L+ F+ A + WL E +L +
Sbjct: 2475 QEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMG 2534
Query: 8061 --------TNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA 8112
N+ + + VQ +K+ +A +Q+ H ++ + AQG L +
Sbjct: 2535 VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQ----HEQLNEA-AQGILTGPGDVSLSTS 2589
Query: 8113 IIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDR 8172
+++EL + + E+ ++ ++ + + ++ ++L + A L
Sbjct: 2590 QVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRL----- 2644
Query: 8173 SADSLLSPQPSS-NLSLSLAQPLRSE-----RSGRDTPASVDSIPLEWDHDY---DLSRD 8223
S S +S QP + L +RS+ ++ D + + Y +L +
Sbjct: 2645 SVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKR 2704
Query: 8224 LESAMSRALPSED-EEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSA 8282
LE+ ALP + E+ D+ L+ A+ S + + ++ + ++ D +
Sbjct: 2705 LETV---ALPLQGLEDLAADRINRLQAALA--------STQQFQQMFDE-LRTWLDDKQS 2752
Query: 8283 LESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRL 8342
+++ + L+ + Q+Q+ E +S L+ Y ++ E S + SV
Sbjct: 2753 QQAKNCPISAKLERLQSQLQENEEFQKS-------LNQHSGSYEVIVAEGESLLLSVPPG 2805
Query: 8343 EHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLN 8402
E K + + Q + + WE L + ++ R+K +QK Q++ +
Sbjct: 2806 EEK--------------RTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 2851
Query: 8403 SIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFT 8462
+ W+ D + ++ +L+ ++ D +E + + K + V+ R++++ +N +
Sbjct: 2852 DLVPWIEDCKAKMSELR---VTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILI 2908
Query: 8463 QADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 8522
+ + ++D + +N D V L+ G L++ + + F E + + ++
Sbjct: 2909 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNI---EKKVE 2965
Query: 8523 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLES-QLRVASLQDMSCQLLVNA-EGTDC 8580
K+++ D+ L ++ + + + ++ + E+L++ + +V L++ + L+ +A +G+D
Sbjct: 2966 GAKHQLEIFDA-LGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3024
Query: 8581 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLL-----------DVSSSQQDLSSWSSADE 8629
+ + V + + V+ +E L ++ S DL DE
Sbjct: 3025 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD-----DE 3079
Query: 8630 LDTSGSVSPTSGRSTPNRQ 8648
LD G++ GR T + Q
Sbjct: 3080 LDGMGAI----GRDTDSLQ 3094
Score = 93.2 bits (230), Expect = 1e-17
Identities = 304/1779 (17%), Positives = 664/1779 (37%), Gaps = 335/1779 (18%)
Query: 7092 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNN 7151
L +V++Q++ Q++ +E+ S+++ ++ + H ETL ++ ++
Sbjct: 612 LPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLG----KLETQYCK 667
Query: 7152 LLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLK--AATNKDIAD---- 7205
L E SS + L +K S+ A + E EL + N +I+
Sbjct: 668 LKET------SSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNY 721
Query: 7206 -DEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCA 7264
E+ +++ D+ + L +D+ L KQ V+A +A A+QS QL + LC
Sbjct: 722 FSELTMELEEKQDVFRSL---QDTAELLSLENHPAKQTVEAYSA-AVQS-QLQWMKQLCL 776
Query: 7265 LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQ-DPSHSSDLSTI----Q 7319
+ K+ T+ Y F LE+++ ++ ++ + H++ LS + Q
Sbjct: 777 CVEQHVKENTA-------YFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQ 829
Query: 7320 ERMEELKGQMLKFSSMAPDLDR---LNELGYRLP------------------------LN 7352
+ M+E + + SS+A + R + +L R P N
Sbjct: 830 DSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKN 889
Query: 7353 DKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQ-------------HQTFLEKCETWME 7399
D+ + + W +IS E FL+ Q++ + W +
Sbjct: 890 DECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQ 949
Query: 7400 FLVQTEQ-------------------------------KLAVEISGNYQHLLEQQRAHEL 7428
V T+ ++ + +Y+ L+ R L
Sbjct: 950 LHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVL 1009
Query: 7429 FQ-AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGII 7487
F A+ ++ + + Q L++ + +D++E K+ + ++ + + R ++ +
Sbjct: 1010 FSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYI--SELKNIRLRLEEYEQRV 1067
Query: 7488 DSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ 7547
+I+ R + W + + L ++ LQQ R+ D V K FL Q
Sbjct: 1068 VKRIQSLASSRTDRDA---W--QDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQ- 1121
Query: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKC 7607
S S + L++EL + EK KL K +
Sbjct: 1122 ---------------SPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKL----KTVDVI 1162
Query: 7608 EKGIADSLEKLRTFKKKLSQ---------SLPDHHEELHAEQMRCKELENAVGSWTDDLT 7658
+ I D+ ++ ++ KLSQ +L H L K+ + +++
Sbjct: 1163 VRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIA 1222
Query: 7659 QLSLLKDTLSAYISADDISI--LNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSE 7716
+ ++ + +S ++ + E+ LQ +W + QL +R+ ++ +
Sbjct: 1223 KAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRA 1282
Query: 7717 KNKELCEWLTQ-------MESKVSQNGDILIEEM----------------IEKLKKDYQE 7753
+ L +W+ + M+ +++ +L E++ +++ +K Q+
Sbjct: 1283 CHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQ 1342
Query: 7754 EIAIAQENKIQLQ--------QMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAAR 7805
I ++ ++QL Q + S + I + + R+ L+ L
Sbjct: 1343 YSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQH 1402
Query: 7806 VKKLKETLVAVQQLDK-----------NMSSLRTWLAHI-ESELAKPIVYDSCNSEEIQR 7853
VK + + L +++ +K + L W++ + + K ++ S +I++
Sbjct: 1403 VKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEK 1462
Query: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
+ EQQ L ++ V+ + ++ L ++ E I + L++ + ++C
Sbjct: 1463 AILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLC 1522
Query: 7914 AMSMER--RLKIEETWRLWQKFLDD-----YSRFED---WLKSSERTAAFPSSSGVIYTV 7963
S + +L+ + + QK L + + ED W+ +ER A +
Sbjct: 1523 DGSANQLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDL 1582
Query: 7964 A--KEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA----CSLKQMVHEGNQR 8017
+ ++ + Q + T + K EN+T + +L++ +H+ ++
Sbjct: 1583 SALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQ 1642
Query: 8018 WDNLQKRVTSILRRLKHFIGQREEFETAR--------------DSILVWLTEMDLQ---- 8059
++ LQ+ + L+ + + ET + D++L W+T +
Sbjct: 1643 YEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQL 1702
Query: 8060 LTNIEHFSECD------------------------VQAKIKQLKAFQQEISLNHNKIEQI 8095
LTN+ + + + + +KA QE+
Sbjct: 1703 LTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILA 1762
Query: 8096 IAQGEQLIEKS----EPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDL 8151
+ +++ P + +++++L EL+ + E K++ L D+
Sbjct: 1763 TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQV--QTLQDELQKF 1820
Query: 8152 SDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIP 8211
E E W +RS L + + +L L+ + S + S
Sbjct: 1821 LQDHKEFES--------WLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVIS----- 1867
Query: 8212 LEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTEN 8271
H DL R + ++ D ++ + G + P L ++
Sbjct: 1868 ----HKGDL---------RFVTISGQKVLDMENSFKEG----------KEPSEIGNLVKD 1904
Query: 8272 AIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGE 8331
+K+ + ++AL S+ +LG L+ Q Q +N S + + + KLL +
Sbjct: 1905 KLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVE---KLLSD 1961
Query: 8332 CSSS--------IDSVKRLEHKLKEEE----------------ESLPGFVNLHSTETQTA 8367
+S + + K+L+ +L E + E P + H ET T
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET-TD 2020
Query: 8368 GVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDI 8427
++ ++ L + +++ + + Q L S+ +G+ E+ LE Q LS+ +
Sbjct: 2021 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2080
Query: 8428 QTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ-ADSKESRDLQDRLSQMNGRWDRV 8486
I+ + +L++ + +K+ + + F + ADS + LQ +L++++ R++++
Sbjct: 2081 --IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQL 2138
Query: 8487 CSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQ 8546
C +E L+ L Q + F +S L +EN K+ ++ + D +I +Q
Sbjct: 2139 CLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN----KSRMLASGNQPDQDITH-FFQQ 2193
Query: 8547 LMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIK 8606
+ ++ E+ + Q + +L+ + +L D + +++V L+ E+ + +K
Sbjct: 2194 IQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRV----QNLRKDFTELQKTVK 2249
Query: 8607 ELEKLLDVSSSQQDLSSWSSADEL------DTSGSVSPT 8639
E EK D SS Q+ L + +T GS+ PT
Sbjct: 2250 EREK--DASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT 2286
Score = 34.3 bits (77), Expect = 5.6
Identities = 48/227 (21%), Positives = 90/227 (39%), Gaps = 12/227 (5%)
Query: 8400 DLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSP 8459
+L ++ L EE +L+R E D+ ++ELQ++ + + +V+ + + L
Sbjct: 585 NLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARL--- 641
Query: 8460 EFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLE 8519
+ K S++ ++ G+ + L+E L F + L+ L
Sbjct: 642 ----YEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLN 697
Query: 8520 NIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQL-LVNAEGT 8578
+ + D+N + +++ +L EL E Q SLQD + L L N
Sbjct: 698 EKEEEELAYDWSDNNSNISAKRNYFSELTM---ELEEKQDVFRSLQDTAELLSLENHPAK 754
Query: 8579 DCLEA-KEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSW 8624
+EA V +K L V +H+KE S ++L S+
Sbjct: 755 QTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESF 801
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 336 bits (861), Expect = 7e-91
Identities = 707/4022 (17%), Positives = 1549/4022 (38%), Gaps = 508/4022 (12%)
Query: 1235 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1292
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1314 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1370
Query: 1293 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1349
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1371 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1429
Query: 1350 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1405
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1430 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1487
Query: 1406 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1460
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1488 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1541
Query: 1461 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1513
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601
Query: 1514 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1573
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1602 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1658
Query: 1574 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1633
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1659 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1700
Query: 1634 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1680
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1701 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1756
Query: 1681 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1720
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1757 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1816
Query: 1721 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1780
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1817 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1874
Query: 1781 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1835
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1875 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1934
Query: 1836 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1883
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1935 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1991
Query: 1884 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1937
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 1992 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2050
Query: 1938 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1995
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2051 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2110
Query: 1996 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2111 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2170
Query: 2056 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2171 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2230
Query: 2115 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2169
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2231 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2276
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2223
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2277 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2330
Query: 2224 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2276
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2331 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2389
Query: 2277 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2335
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2390 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2431
Query: 2336 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2395
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2432 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2490
Query: 2396 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2455
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2491 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2524
Query: 2456 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2515
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2525 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2561
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2562 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2619
Query: 2576 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2631
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2620 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2679
Query: 2632 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2689
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2680 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2739
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2740 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2798
Query: 2750 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2800
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2799 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2849
Query: 2801 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2857
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2850 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2908
Query: 2858 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2917
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2909 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2950
Query: 2918 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2977
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2951 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3008
Query: 2978 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3037
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 3009 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3068
Query: 3038 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3078
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3069 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3128
Query: 3079 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3138
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3129 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3188
Query: 3139 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3198
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3189 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3242
Query: 3199 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3253
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3243 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3296
Query: 3254 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3308
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3297 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3356
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3368
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3357 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3416
Query: 3369 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3428
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3417 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3476
Query: 3429 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3482
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3477 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3536
Query: 3483 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3539
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3537 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3596
Query: 3540 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3597
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3597 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3654
Query: 3598 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYR-DEVEEVGARAQEILDESHV 3656
+ R + +++ WL E + E + +E + R +E+ E+
Sbjct: 3655 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3714
Query: 3657 NSRMGCQATQLTS-----------------------RYQALLLQVLEQIKFLEEEIQSLE 3693
N + +++S RY+ + + ++++ ++ I +
Sbjct: 3715 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3774
Query: 3694 ESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3750
+ + + + W T K + + + D+ + +K T+E+L + ++
Sbjct: 3775 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKDIID 3829
Query: 3751 SAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKC 3810
+ G + + E E + ++K++ ++ + + ++ LE+ L +F +
Sbjct: 3830 DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3889
Query: 3811 KALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE 3870
+ L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G LLE
Sbjct: 3890 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3949
Query: 3871 LV-------------------------------------QDVTLKDKIDQLQSDYQDLC- 3892
L Q DKIDQ+ + +
Sbjct: 3950 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4009
Query: 3893 -------------------SIGKAMMEEIAGFEDRLNNLQMKGDTLIGQC--------AD 3925
S K + ++ + L+ +G+ +I + A
Sbjct: 4010 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4069
Query: 3926 HLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA 3979
+Q KL Q N+H ++ + + A++ + H+S T++ Q
Sbjct: 4070 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIKDTQD 4122
Query: 3980 WLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLSNASV 4033
++ ++ P ++PS + AE I++ LQE+ ++L L + C + V
Sbjct: 4123 FIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPDKPIV 4180
Query: 4034 KTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH 4089
K + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4181 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4240
Query: 4090 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHLNDQ- 4146
++LE + + ++K F + +Q + + + L KK EES +H + L +
Sbjct: 4241 TDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4298
Query: 4147 --WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHL 4204
W L + N + E L + ++ + +L + A+ +
Sbjct: 4299 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4358
Query: 4205 EALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK 4262
E K L + + +E + +IE ++ ++ + L QRW + + +
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4418
Query: 4263 RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4322
++ Q L + ++L +W + + ++ + P+ A+ L H+ +C+
Sbjct: 4419 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAA 4478
Query: 4323 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4382
EAK+ KSL++ +++A + I + +++ + + + +R+ L +AL+
Sbjct: 4479 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4538
Query: 4383 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4442
+F ++ + + Q E+ + L+ D V Q+ K + +++ ++ L
Sbjct: 4539 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIEL 4598
Query: 4443 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4502
G L +Q+ + L +QS ++ V+Q+ R + L+ K F E + K
Sbjct: 4599 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4658
Query: 4503 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4562
WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4659 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4718
Query: 4563 NEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L +E
Sbjct: 4719 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4778
Query: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTGQPWQ 4677
Q V D ++ ++L D +A E+ +V L + EG R W
Sbjct: 4779 QLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WV 4835
Query: 4678 PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEET 4737
+M L T + + + + + LE +E + L L + EQ+
Sbjct: 4836 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLRFHGV 4893
Query: 4738 LPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792
LP +E + + L++ L + T + + P + +H I +
Sbjct: 4894 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4953
Query: 4793 ELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE 4852
+ + + + S + I Q + L WL+ + L+ D + + I +E
Sbjct: 4954 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEVIPQE 5008
Query: 4853 IRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRT 4912
I +++ E Q+ + M + +K TK + +AD + + LD R
Sbjct: 5009 IEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRF 5067
Query: 4913 RQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLAGNGL 4952
++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5068 PASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDF 5127
Query: 4953 DV 4954
D+
Sbjct: 5128 DI 5129
Score = 322 bits (825), Expect = 1e-86
Identities = 858/4699 (18%), Positives = 1838/4699 (39%), Gaps = 637/4699 (13%)
Query: 3186 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3243
E++ + +QD L+ ++M + + DLP+ + ++V I +E L K
Sbjct: 631 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 690
Query: 3244 AQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWM 3303
Q+ ++ ++ +L SQY L N ++ + LD + HN S EL W+
Sbjct: 691 EIQMTA--PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELI-WL 744
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
+ +Y + ++ + E + + Q++E +K + E +L P +
Sbjct: 745 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE-NIKSVQEIAEQLLLENHPARL 803
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEA-----N 3418
TI+ +++ W+ +L C+ +E + + T+Y F + D+ EA N
Sbjct: 804 -TIEAYRAAMQTQWSWILQL---CQC-VEQHIKENTAY------FEFFNDAKEATDYLRN 852
Query: 3419 LNESERQHAELRDKTTMLGKAKLL-------NEEVLSYSSLLET--------IEVKGAGM 3463
L ++ ++ D+++ + K + L EE+L Y S + I++K
Sbjct: 853 LKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 911
Query: 3464 TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQE----- 3518
T + ++ + + YR I+ + K ++ V + ++ K G E
Sbjct: 912 DCPLKTSIPIKAICD-YRQIEI----TIYKDDECVLANNSHRAKWKVISP-TGNEAMVPS 965
Query: 3519 ---------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPS 3569
+E +D + +E T + L+N + R + S
Sbjct: 966 VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVAS 1025
Query: 3570 ---GIPQAEDRALESLRQDWQAYQHRLSETR-------TQFNNVVNKLRLMEQKFQQVDE 3619
+P + L +L+ ++ + E++ TQ VN + Q E
Sbjct: 1026 IKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK------QYYQE 1079
Query: 3620 WLKTAEEKKWHEEV-TAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQV 3678
LK+AE ++ E V Y EV + R + D R + L + ++
Sbjct: 1080 LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHES----VFRI 1135
Query: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGK-------- 3730
EQ K L++E++ L++ ++++ + + S +V T +++ V+
Sbjct: 1136 TEQEK-LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 1194
Query: 3731 ----KLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3786
KLKT+ ++LK+ + +L+K K L E EA K ++ L
Sbjct: 1195 TYIDKLKTVNLVLKNTQAAEALVKLYETK-------LCEEEAVIADKN------NIENLI 1241
Query: 3787 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK-YK 3845
ST++ QW +E E V + EL + KA + +K
Sbjct: 1242 STLK------------------------QWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1277
Query: 3846 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGF 3905
+ ++ L + +EK + L+E Q+V + Q+ + +DL IGK++ +
Sbjct: 1278 TYKERDLDFDWH----KEKADQLVERWQNVHV-----QIDNRLRDLEGIGKSLKY----Y 1324
Query: 3906 EDRLNNLQMKGDTLIGQCADHLQAKLKQNV--HAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
D + L D I Q + Q K+++N ++ T+ + + + M QS E
Sbjct: 1325 RDTYHPL----DDWIQQ-VETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1379
Query: 3964 LQKHVSRQD-TLQQCQAWLSAVQPDLEPSPQPPLSR----AEAIKQVKHFRALQEQARTY 4018
QK+ + T++ + + ++ + P+ R + A ++ F L+ +
Sbjct: 1380 CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL 1439
Query: 4019 LDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA 4078
+ L+ + S+K ++ + E+ ++ + +A+ L Q W S + L+DA
Sbjct: 1440 VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-QKWV------SNISKTLKDA 1492
Query: 4079 DQQLQN--MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE 4136
++ + K++ S E++ + +S+ ++ +K +K+T +E +
Sbjct: 1493 EKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG---------DKMTDEERNEL 1543
Query: 4137 HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV----EVFLEKFTTEWDNL 4192
K++ L + + L +S L++ ++ Q + D +V + + EK D L
Sbjct: 1544 EKQVKTLQESYNLLFSES----LKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1599
Query: 4193 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4252
+++ H EA ++ +KY + +++ QK ++ E+VK + L++
Sbjct: 1600 TQTENRLIG-HQEAFMIGDGTVELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKE 1656
Query: 4253 RWFQLED----LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4308
+L LI++K+ + E+LN+ + ++ E + A+K+
Sbjct: 1657 NGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK------ELDKVVTTAIKEET---- 1706
Query: 4309 AQNLLMDHLAICSELEAKQMLLKSLI---KDADRVMADLGLNERQVIQKALSDAQSHVNC 4365
+ +A +LE + +++L+ + D+ G +QVI++ + Q
Sbjct: 1707 ------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG- 1759
Query: 4366 LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4425
+G+ + L + Q + Q +K+ ++ K
Sbjct: 1760 -KSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKVK------------AQHEKII 1804
Query: 4426 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL------QKC 4479
QA + Q+ L QG+ L E EK ++ ++EL+ Y++ L K
Sbjct: 1805 SQHQAVIIATQSAQVLLEKQGQYLSPE----EKEKLQKNMKELKVHYETALAESEKKMKL 1860
Query: 4480 SHRLQE-LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE----LHTQLAKY 4534
+H LQE LEK F D+ + HWL+Q++ E+ + ++ L T+L +
Sbjct: 1861 THSLQEELEK-------FDADYTEFEHWLQQSE----QELENLEAGADDINGLMTKLKRQ 1909
Query: 4535 QNILEQSPEYENLLLTLQRTGQTILPSLN--------EVD----HSYLSEKLNALPRQFN 4582
++ E ++ L + +G +L + +VD H + KL+ +F
Sbjct: 1910 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR 1969
Query: 4583 VIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ 4642
+ + +++ + +Y + + L+ L+A SK ++ + +LQ
Sbjct: 1970 SLYSKCNVLGNNLKDLV---DKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2026
Query: 4643 ---DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK------MLHLVTLYHRLKR 4693
+ +A+ +++ AV++L + E P K + +V Y L +
Sbjct: 2027 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2086
Query: 4694 QTEQRVSLLEDTT----SAYQEHEKMCQQLERQLKSVKEE-QSKVNEETLP--AEEKLKM 4746
+R L+ T S ++M + S+KE+ Q +N L + + +
Sbjct: 2087 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2146
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+AG + ++V +E DP + +++ + ET+
Sbjct: 2147 EQDIAGRQSSINAMNEKVKKFMETT----DPSTASSLQAKMKDLSARFSEASHKHKETLA 2202
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
+ E + ++ +S L K + V D+ +D+ E + +Q E
Sbjct: 2203 KMEE-LKTKVELFENLSEKLQTFLETKTQALTEV--DVPGKDVTELSQYMQESTSEFLEH 2259
Query: 4867 LRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQR 4926
+ + L KE + A + LS+ ++++ ++ ++ +T Q
Sbjct: 2260 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2319
Query: 4927 YYQVFQAANDWLEDAQE---LLQLAGNGLDVESAEENLKSHMEFFSTE----DQFHSNLE 4979
+ + ++ W+++ + ++Q + D+ + E+ K E +S + + +++
Sbjct: 2320 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2379
Query: 4980 ELHSLVATLDPLIKP-----------------TGKEDLEQKVASLELRSQRMSRDSGAQ- 5021
L +L++ + K T E+ ++ G +
Sbjct: 2380 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYED 2439
Query: 5022 -----VDLLQRCTAQWHDYQKAREE---VIELMNDTEKKLSEFSLLKTSSSHEA-EEKLS 5072
D + + QKA+EE +++ + K +++ + EA + ++
Sbjct: 2440 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2499
Query: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTT-VWQRWTRLRAVAQDQ 5131
++K+ + + K+ L++K ++L + D +A + M T + +W L + D+
Sbjct: 2500 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2559
Query: 5132 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV---- 5187
++ LE++ + T F ++ +L EK +L L +
Sbjct: 2560 QQKLEESSNNLTQFQT-----------VEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2608
Query: 5188 --LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLM----QEITAMQDRCLNMQEKVK 5241
+++ Q+ A + + L+ G PGE+P L +++ A+ + ++ ++
Sbjct: 2609 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2668
Query: 5242 TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI------EIDAQLEELQILLTE 5295
+ Q + ++ + S+ + + L + ++ QLE Q + E
Sbjct: 2669 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2728
Query: 5296 ATNHRQNI-------EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIK 5347
++ I E ++ KE+YL +ELS QL + K + + ++ ++
Sbjct: 2729 IQQEKKQIKVAQALCEDLSALVKEEYL------KAELSRQLEGILKSFKDVEQKAENHVQ 2782
Query: 5348 EVEQSKATS---QELSRQIQK---LAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5401
++ + A+S Q++SR Q K+ + AK D + D K + L
Sbjct: 2783 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA- 2841
Query: 5402 NSKLMELDAAVQK--FLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5459
S + E A + L+ G L ++ + +Q + R +KL ++
Sbjct: 2842 QSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2901
Query: 5460 EYNEMLELILKWIEKAK----------VLAHGTIAWNSASQLREQYILHQTLLEESKEID 5509
+Y E +E + WI+K + A G + L+++ H ++E
Sbjct: 2902 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA 2961
Query: 5510 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5569
+ L ++ E + T++ + ++ TE+L K L+N+ K+ ++ E
Sbjct: 2962 NSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KFCLENMTQKFKEFQEVSKE 3016
Query: 5570 LKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ-AVQLCQSALRI 5627
K+ LQ A EQ + + + L+ Q +++LK +V A +L Q +
Sbjct: 3017 SKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVE 3074
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
D + + + +E S L ++C+ ++ + ++ ++ +
Sbjct: 3075 ASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD 3134
Query: 5688 REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5747
E++ + + LQ Q + +K++ + N CKM+ + + L+ +
Sbjct: 3135 DELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGI 3194
Query: 5748 -TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE-----ESGEEGTNSE 5801
++E L++ +LL A V T R S + E + EE S+
Sbjct: 3195 KRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3250
Query: 5802 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5861
PV ++NQ + ++ E ++ K Q + + +
Sbjct: 3251 ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3300
Query: 5862 ATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS-ISTKMEAIELKLS 5916
+T L D+ W+TL ++++ L EAL ++QD+L+S +S ++ EL +
Sbjct: 3301 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3360
Query: 5917 ESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE-----ADPAEQLA 5971
+ P P ++ +A + E +LQ +++ +S++ E++ E A+PA+++
Sbjct: 3361 QKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVIKREGEKIATTAEPADKVK 3413
Query: 5972 LQSTLTVLAERMSTIRMKASGKRQLLE-------------EKLNDQLE--EQR------- 6009
+ L++L R + KA + + LE E LN+ L E+R
Sbjct: 3414 ILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPI 3473
Query: 6010 --QEQALQRYRCEADELDSWLLSTKATLDTALS--------PPKEPMDMEAQLMD-CQNM 6058
Q L+ + L+ +++ L A+S +E DM +D Q
Sbjct: 3474 GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW 3533
Query: 6059 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QLAGKLRRL----------- 6101
+EI++K + SEL + L K +DE E ++ KL +L
Sbjct: 3534 YIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3590
Query: 6102 --KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6159
+ L LQ + ++ N+ E T + +Q+ L + + + S
Sbjct: 3591 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3650
Query: 6160 LQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG-MEGEKS 6218
K LEQ L L R + S EE+ E ++LS E ++GE++
Sbjct: 3651 TDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV--------ELLSYETQVLKGEEA 3698
Query: 6219 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S Q +M+ + L +E + LL + L + +L P R G+ + +D
Sbjct: 3699 S---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWRAREGLE----KMVAEDNE 3750
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 6338
+ D + Q EE+ + +I Q+ A +W+ + E++L +
Sbjct: 3751 RYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3802
Query: 6339 EETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
E+ +T F EIL K++ +++ K+ + A E + + ++ L +L
Sbjct: 3803 EQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTACSE--EEKQSMKKKLDKVL 3858
Query: 6392 GRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADNKYIILQKLANVFE-QPVA 6449
+ + ++R Q+ ER Q ++N F + L+ L + + II Q A E + +
Sbjct: 3859 KNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3917
Query: 6450 EQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQELSKLQD-MYDELMMIIG 6504
+Q E +Q + + E I ++ + G +L P S+QE D +Y ++ +
Sbjct: 3918 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 3977
Query: 6505 SRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQ 6564
R L++ ++ +Q+ + + + LE E++ I + E+I++ + ++K
Sbjct: 3978 KRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSV 4036
Query: 6565 GLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVE--LEYILETWSH 6622
+E L ETL Q E++A++ K + V+ L+ ++ W +
Sbjct: 4037 DMEKLQPLYETL------------KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4084
Query: 6623 L----DEDQQELSRQLEVVE-------SSIPSV----GLVEENEDRLIDRITLYQH---- 6663
+ +E + +L +E+ E S I ++ + + ED ID + Q
Sbjct: 4085 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4144
Query: 6664 --LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHR 6718
++ ++ Q +L V++ G L+ + D ++ +++L W S + +
Sbjct: 4145 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4204
Query: 6719 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV 6778
LE ++ +YQ + W+ A +L + + +LE V+ + +F E
Sbjct: 4205 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTDLETVKQQIEELKQFKSEA 4260
Query: 6779 DAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 6834
Q ++ L+ +LL LKKV D T++ L + W L I Q KL
Sbjct: 4261 -YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4318
Query: 6835 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCK 6892
+ +HA+ E+++W++ E ++ + + +G KAI L K+ + D+
Sbjct: 4319 LLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKAIEIELAKHHVLQNDVLAH 4373
Query: 6893 QLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q TV+ VN++ + +ES ++ ++ +L +N+ WQ + ++ Q L+G L
Sbjct: 4374 QSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4429
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ ++ L+ W E+ L +G + + L ++ +AKE+ + +
Sbjct: 4430 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4489
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
Q G ++ + + + + L + W +++ + + K L+ L+ +
Sbjct: 4490 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4549
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++L +A +L+ + L+ V Q+D + +++ + + L
Sbjct: 4550 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4609
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKALLQLWQRYKDYSKQCAST 7183
+ N L V RW +++ + E+ +S +K + W + ++ ++ +
Sbjct: 4610 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4669
Query: 7184 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
+ + + N+ D++ T + + K LG + G LK++
Sbjct: 4670 LDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK- 4717
Query: 7244 DASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQAGVLDYETFAKSLEALEAW 7296
+++ D L L L L +C ++Q L+ +L F +L+AL W
Sbjct: 4718 -----TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDW 4772
Query: 7297 IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7356
+ E L P H D+ + ++ K + + L L ++
Sbjct: 4773 LYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4831
Query: 7357 K-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7411
+MQ L+ W + + + + ++L++ L Q + F +E+L + EQ L
Sbjct: 4832 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4891
Query: 7412 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLL 7469
+ + L H+ F ++ ++ L+ G +L D +T++
Sbjct: 4892 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4951
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-EVSYLPMSGLGSVPIPLQQ 7528
+++ V+ A+Q + + S + +E+ E L WL + L +P +++
Sbjct: 4952 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 5011
Query: 7529 ARTLFDEVQ-FKEKVFLRQ 7546
+ L E Q F E++ +Q
Sbjct: 5012 VKALIAEHQTFMEEMTRKQ 5030
Score = 312 bits (799), Expect = 1e-83
Identities = 770/4311 (17%), Positives = 1668/4311 (38%), Gaps = 501/4311 (11%)
Query: 1482 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1535
S S + ++ V Q + L S E+E + +++ + R++ + + Q
Sbjct: 1059 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1118
Query: 1536 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1594
IR E H T L ++ ++ +++L I EF + A + + +E
Sbjct: 1119 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1178
Query: 1595 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1654
VLQ + S+SS + V+ Q A AL + YE L
Sbjct: 1179 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1227
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
E ++A +E +S+ W R +V+ + Q+ AL++E+
Sbjct: 1228 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1265
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
K + + +F + D+ K +QL ERW+++ I+ R+ L+ +
Sbjct: 1266 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1319
Query: 1773 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1824
+ + + WI+ +++TT I ++Q L + K +E+E K+
Sbjct: 1320 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1374
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1881
++ Q + + + + +L + +A + + V+RR++ S + EF+
Sbjct: 1375 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1430
Query: 1882 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1938
+ ++ + Q ++ A +S+ + E + +E++ + ++ AK L+ ++ L
Sbjct: 1431 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1490
Query: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1998
A+ K S+Q+ S ++++ + E++ L T Q L + K
Sbjct: 1491 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1532
Query: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2057
++ TD+ER N+LE ++ + + L + KQ+ +
Sbjct: 1533 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1570
Query: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
+ +V+ +I E + + G+ DL+ + +N +++ + + ++
Sbjct: 1571 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1615
Query: 2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2176
T+ +LK SK E + M + L ++ L E +K+ D +L++
Sbjct: 1616 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1671
Query: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2236
+ K ++ K E++ L D V++T + E V Q+ E+ + ++N
Sbjct: 1672 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1724
Query: 2237 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2296
L ++ S V + R H +V + F E D +
Sbjct: 1725 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1767
Query: 2297 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2356
E+ T D +TQ ++ + KV+ AQ+E K +
Sbjct: 1768 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1804
Query: 2357 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2410
Q+ I +TQ L + E E L + M L +E A S+ K SL
Sbjct: 1805 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1864
Query: 2411 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470
QE LEK F EF+ W ++ + D L KL ++ + V + L
Sbjct: 1865 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1923
Query: 2471 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2518
+T G + ++ +S +Q ++ A + F++ +C L+
Sbjct: 1924 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1983
Query: 2519 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2577
D + +ED L + E + ++L E P+ + ++ + + G++ +
Sbjct: 1984 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2042
Query: 2578 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
+ +++KL + + LL G + ++ +++L + E+ Q+ L
Sbjct: 2043 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2102
Query: 2634 EALEEALQSMWFWVKAIQDRLA----CAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN 2689
++++ L M W+ ++ L ++ +D + K + QDI + +N
Sbjct: 2103 LSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI----AGRQSSIN 2158
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
K ++ + +++ +Q +++ L +++ + +E + ++ +
Sbjct: 2159 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2218
Query: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--- 2806
+L+ ++E+ Q + P + E + S E + H LH L+ +
Sbjct: 2219 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL 2278
Query: 2807 ------LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD------ 2854
+ EKT + S K E+ + + +T +E++ + +VK ++
Sbjct: 2279 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2338
Query: 2855 -------AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRV 2907
+ L K+ +WS + + + LI + A ++ V
Sbjct: 2339 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2398
Query: 2908 ESLAPEVKQNTTASGCELMHTE--MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965
+S + TA+ E + +++ D L++ ++ E
Sbjct: 2399 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA-------EL 2451
Query: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGK------NTDEEIVECWHKGQEILDA-LQK 3018
+ ++++L++A E+ SA+++ W Q++ K TD E V+ + + +A L++
Sbjct: 2452 NTKLSKLQKAQEESSAMMQ-WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2510
Query: 3019 AEPRTEDLKSQLNELCRFSRDL------STYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
+ ++LK +L EL + D ++ +E N L + + + L
Sbjct: 2511 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2570
Query: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132
Q F+ +QWLV ++ + + + + ++T Q++Q L E + + +
Sbjct: 2571 TQ-FQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2629
Query: 3133 SKGE-LLSTLLTKEKAKGI-QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAE 3190
+ G+ +LS +GI + ++ A + W + L + ++ ++ ++
Sbjct: 2630 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2689
Query: 3191 PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEG 3250
+ D LS + + S A ++ + Q + +EI + Q+ + AQ L E
Sbjct: 2690 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI----KVAQALCED 2745
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKE-------KVSRLDRIVAEHNQFSLGIKELQDWM 3303
+A + ++LS Q + K+ V L A +QF ++ Q W+
Sbjct: 2746 LSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL 2805
Query: 3304 TDAIHMLDSYCHPTSDK-SVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362
D + HP S K VL+S + + + + GE++L T
Sbjct: 2806 -DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE 2864
Query: 3363 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE- 3421
+Q QL ++K W + +++L+ +L K Y++ V W+D + NL E
Sbjct: 2865 KAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI 2924
Query: 3422 --------SERQHAELR----DKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
E A+L+ + G +LLN +SLL E+ +T+
Sbjct: 2925 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA---NSLLSVCEIDKEVVTD---- 2977
Query: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529
E + L ++ + E+ E + + +E+Q K + L +E+LD + L
Sbjct: 2978 --ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3035
Query: 3530 GDAHTHE-TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRAL--ESLRQDW 3586
A++++ T+ Q+ + + Q L L V S D L E++ Q+
Sbjct: 3036 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3095
Query: 3587 QAYQHRLSE------TRTQ-FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDE 3639
++ E T+ Q + N +R M +F + D+ L + E + E
Sbjct: 3096 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3155
Query: 3640 VEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL------- 3692
+ + E L S+ N+ C+ T L+ + ++ L ++ L
Sbjct: 3156 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3215
Query: 3693 -EESESSLSSYSDWYGSTHKNFKNVATKIDK---------VDTVMMGKKLKTLEVLLKD- 3741
E+ E ++ ++Y S K F + K ++ ++T + ++L +V K+
Sbjct: 3216 EEQVEGTIKRLEEFY-SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3274
Query: 3742 MEKGHSLLKSAREKGERAVKYLEEGEAER-LRKEIHDHMEQLKELTSTVRKEHMTLEKGL 3800
+E + G+ ++ + + + L ++ D + K L V + L++ L
Sbjct: 3275 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3334
Query: 3801 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3860
F D ++L W+ + +E++ + P E KAQ+ + K LQ+ + + +V+
Sbjct: 3335 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3394
Query: 3861 VREKGEALL---ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
++ +GE + E V + ++ L S ++ L + KA N Q++G
Sbjct: 3395 IKREGEKIATTAEPADKVKILKQLSLLDSRWEAL--LNKA----------ETRNRQLEGI 3442
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977
+++ Q L + + T + C LE ++ +H + +D +
Sbjct: 3443 SVVAQQFHETLEPLNEWLT-----TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3497
Query: 3978 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037
L +S +++K + +R D++ S D S
Sbjct: 3498 NKHLHQA-----------VSIGQSLKVLS--------SREDKDMVQSKLDFSQVWYIEIQ 3538
Query: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELEL 4094
+ + ++Q L A+ + E+ + +E+ L D + + ++ SEL
Sbjct: 3539 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR- 3597
Query: 4095 NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS 4154
V Q ++K QA +N + E + + T E ++ + ++ D+ + S
Sbjct: 3598 ------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3650
Query: 4155 NNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4209
++ E+ LQ R H C + +V +E + E L +A + + LKK
Sbjct: 3651 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3710
Query: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VS 4268
A + K ++ L + ++E + +E +++ + +R+ + D I +K++ +
Sbjct: 3711 EA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3767
Query: 4269 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328
L Q+ EL W E + + D L E+ +
Sbjct: 3768 AAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKD 3826
Query: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388
++ L+K ++M E+Q ++K L + + + + +R L +A S QF
Sbjct: 3827 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3886
Query: 4389 MAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4448
+ + + + I L + + +Q + + + + ++ + + G +
Sbjct: 3887 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3946
Query: 4449 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4508
L+ E++ E + K ++Y + + R L++ + F + D+ L+
Sbjct: 3947 LL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4005
Query: 4509 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHS 4568
+ ++ E ++ Q+++ +N+ + + L TL++ G+ ++ D
Sbjct: 4006 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4065
Query: 4569 Y----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQF 4623
+ +KL+ + + I L +++ K+ + + LA K + + L ++ + + F
Sbjct: 4066 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DF 4123
Query: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP---D 4679
+R + P + Q+ I +E+ GL E +D +N E + G+P +P
Sbjct: 4124 IRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4182
Query: 4680 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE---- 4735
+ L + + L + + R+ LE+ A +++ Q + + + + ++
Sbjct: 4183 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD 4242
Query: 4736 -ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGE 4793
ET+ + E+LK + S A Q I ++R+ E L L + E +H +Q E
Sbjct: 4243 LETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLME 4296
Query: 4794 LKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4849
LKL+ ++ E + + ++ ++ FQ + L WL + LS + + + I
Sbjct: 4297 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356
Query: 4850 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4909
+ E+ K + Q +V + + A++ + + +++L++ L L++ ++ E
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME- 4966
R+ L Q + ++ + WL D + L LA L E+A+E L HME
Sbjct: 4417 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHMEV 4475
Query: 4967 ---FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5023
F + E+ + S +++ ++A + + +++Q + +L+ + + + +
Sbjct: 4476 CAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERKT 4531
Query: 5024 LLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVSV 5080
L+ ++ + ++ I + E+ L S SL+ + + + EHK +
Sbjct: 4532 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFANE 4587
Query: 5081 VNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140
VNS E+I+ L++ + L+ + + +V RW ++ ++ + L+DA
Sbjct: 4588 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4647
Query: 5141 EWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGML 5200
F+ K E +++ + L ++ T L H F L + S
Sbjct: 4648 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4707
Query: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV-- 5257
+ S+ E+ L + + D +++K T GK V+++ K E +
Sbjct: 4708 NRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLF 4758
Query: 5258 ----ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQKE 5312
+ ++ W+ Y P + D + ++ +++ NH+ +
Sbjct: 4759 SGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AFQ 4804
Query: 5313 KYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTT 5372
K LG T S+Q AL R+ I+ + K QELS + + + +
Sbjct: 4805 KELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSIS 4855
Query: 5373 ILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGK 5432
T+L+A EE L+E A ++ L +G L +
Sbjct: 4856 KQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRT 4903
Query: 5433 LTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWNS 5487
L + H++ +++ E + ++LN+A + + + + + I WI + +AW
Sbjct: 4904 LIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAK 4963
Query: 5488 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQ 5547
Q R L + ++ LEA+ LQ+ + T+K + + + E EE++
Sbjct: 4964 QHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVKA 5014
Query: 5548 MI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
+I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5015 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5065
Score = 298 bits (764), Expect = 1e-79
Identities = 722/4020 (17%), Positives = 1553/4020 (38%), Gaps = 449/4020 (11%)
Query: 4877 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1137 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1196
Query: 4928 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 4972
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1197 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1256
Query: 4973 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5026
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1257 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1316
Query: 5027 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1317 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1373
Query: 5085 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5142
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1374 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1433
Query: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5202
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1434 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1486
Query: 5203 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5256
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1546
Query: 5257 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5316
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1594
Query: 5317 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5359
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1595 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1654
Query: 5360 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5414
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1655 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1714
Query: 5415 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5468
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1715 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1773
Query: 5469 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5525
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1774 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1830
Query: 5526 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1831 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1890
Query: 5586 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5634
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1891 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1950
Query: 5635 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5690
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1951 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1999
Query: 5691 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5748
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 2000 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2047
Query: 5749 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5796
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2048 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2107
Query: 5797 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5848
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2108 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2165
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2166 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2225
Query: 5909 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 5968
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2226 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2284
Query: 5969 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6018
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2285 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2344
Query: 6019 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2345 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2402
Query: 6079 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6135
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2403 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2462
Query: 6136 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6184
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2522
Query: 6185 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6228
E+L E + D E P D QEL + E+SS
Sbjct: 2523 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2576
Query: 6229 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6266
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2577 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2636
Query: 6267 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6323
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2637 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2695
Query: 6324 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6383
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2696 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2751
Query: 6384 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2752 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2809
Query: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6487
P++ +++ ++ K+F + +K E ++
Sbjct: 2810 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2869
Query: 6488 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6546
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2870 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2929
Query: 6547 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6602
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2930 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2989
Query: 6603 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6659
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 2990 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3045
Query: 6660 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6715
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3046 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3105
Query: 6716 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6775
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3161
Query: 6776 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6833
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3162 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3221
Query: 6834 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6889
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3222 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3278
Query: 6890 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 6949
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3279 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3333
Query: 6950 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7008
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3334 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3393
Query: 7009 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7068
I++ G + + ++ L L W L + L+ +
Sbjct: 3394 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3453
Query: 7069 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7128
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3454 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3512
Query: 7129 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7174
+ + + + + W EI E+ S LLQ +
Sbjct: 3513 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3569
Query: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7229
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3570 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3629
Query: 7230 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7283
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3630 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3688
Query: 7284 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7343
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3689 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3723
Query: 7344 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7397
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3724 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3783
Query: 7398 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7455
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3784 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3843
Query: 7456 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3844 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3902
Query: 7516 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7573
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3903 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3953
Query: 7574 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7630
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3954 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4012
Query: 7631 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7679
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 4013 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4071
Query: 7680 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7739
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4072 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4131
Query: 7740 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4132 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4191
Query: 7796 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7853
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4192 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4248
Query: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4249 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4305
Query: 7914 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4306 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4365
Query: 7974 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8033
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4366 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4425
Query: 8034 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8093
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4426 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4484
Query: 8094 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8150
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4485 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4525
Query: 8151 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8209
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4526 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4573
Query: 8210 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 8269
+ + D + ++ S + + D+ G K F + V L ++ + K+
Sbjct: 4574 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4632
Query: 8270 ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELD------TSYK 8323
+ ++ A + +Q +A ++++E + S+ + D +K
Sbjct: 4633 QRLVERGRSLDDA-RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4691
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ +
Sbjct: 4692 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVER 4748
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8443
+ ++++ L QF L ++ WL E +L + Q + DI + I K QK
Sbjct: 4749 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKE 4806
Query: 8444 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8503
+ R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4807 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4866
Query: 8504 CQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4867 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAEL 4922
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4923 NKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4982
Score = 295 bits (754), Expect = 2e-78
Identities = 767/4203 (18%), Positives = 1632/4203 (38%), Gaps = 605/4203 (14%)
Query: 4269 VTNLE-ELNVVQSRFQELMEWAEEQQPN-------IAEALKQSPPPDMAQNLLMDHLAIC 4320
+T LE E+NV + +QEL++ AE ++ I+E + ++ L+ +
Sbjct: 1063 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1122
Query: 4321 SELEAKQMLL------KSLIKDADRVMADLGLN----ERQVIQKALSDA----QSHVNC- 4365
E + + + L K+ +R+ DLG E Q A S + +S +N
Sbjct: 1123 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1182
Query: 4366 ---LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422
++ + Y++K L L A + ++ +E K+ E + +++ +
Sbjct: 1183 LQNMNQVYSMSSTYIDK-LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1241
Query: 4423 KTCKSAQASLK-------TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV--YD 4473
T K ++ + ++E+ A E+ K E++ K + Q V +
Sbjct: 1242 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1301
Query: 4474 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFP-EINLMNESSELHTQLA 4532
+V + +RL++LE S K++++ + W++Q + + N S L TQL
Sbjct: 1302 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1361
Query: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVA--LAKD 4590
+ + ++ + ++ + Q+ + ++ + + ++ + +Q + + +
Sbjct: 1362 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1421
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILD 4650
+QE + R Y +L+ L TQ + R+ EE SL++ + ++
Sbjct: 1422 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE--------EEEKSLEEEKKEHVE 1473
Query: 4651 EVAGLGEAVDELNQKKEGFRSTGQP----------------WQPDKMLHLVTLY---HRL 4691
+ L + V +++ + G+P Q + L + L+ H
Sbjct: 1474 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1533
Query: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
K E+R L + + + + + + +QL+ + EE + AE + + L
Sbjct: 1534 KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQ 1593
Query: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
G R+ H E + +K + + + Q +++ A+ E V E+
Sbjct: 1594 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF 1653
Query: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL-RIM 4870
+ ++ + ++ ++L ++ L + + + ++ + E+ + L +++
Sbjct: 1654 LKENGEKLSQEDKAL---------------IEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1698
Query: 4871 NALSHKEKEKFTKAKELISAD--LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYY 4928
+E EK K+L + +E+ L LS +D D + A + ++ Q ++
Sbjct: 1699 TTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHK----QVIEQNGTHF 1754
Query: 4929 QVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKS--------HMEFFSTEDQFHSNL 4978
Q + E+ + L +D V + +ENL H + S
Sbjct: 1755 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1814
Query: 4979 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5038
+ L+ + P KE L++ + L++ + +S ++ L + +
Sbjct: 1815 QSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1874
Query: 5039 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5098
E + +E++L + KL K SF E +++ + +
Sbjct: 1875 YTEFEHWLQQSEQELENLEA-GADDINGLMTKLKRQK-------SFSEDVISHKGDLRYI 1926
Query: 5099 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5158
+GN +A S S + T A ++ ++ L+ A D + +K +
Sbjct: 1927 TISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1984
Query: 5159 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5218
L DK Y D L Q+
Sbjct: 1985 LVDKYQ----------------HYEDASCGLLAGLQAC---------------------- 2006
Query: 5219 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5278
E TA + ++ E + + K ++++L++ + ++ QI+S + V++ K+
Sbjct: 2007 ------EATASK----HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK---TA 2053
Query: 5279 TIEIDAQ------LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LA 5330
+ +DA+ ++Q L + +++ K E+ EK L L LS+Q L
Sbjct: 2054 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK---LQITLTRSLSVQDGLD 2110
Query: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
E+ L ++ +KE Q S L I K N++
Sbjct: 2111 EM---LDWMGNVESSLKEQGQVPLNSTALQDIISK-----------------NIM----- 2145
Query: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNG-QLGKPLAKKIGKLTELHQQTIRQAENRLS 5449
L +++ G S + ++ V+KF+E L K+ L+ + + + L+
Sbjct: 2146 ---LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2202
Query: 5450 KLNQAASHLEEYNEMLELILKWIE-KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI 5508
K+ + + +E + + E + ++E K + L + ++L QY+ T E E
Sbjct: 2203 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL-SQYMQEST--SEFLEH 2259
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565
LE + L+ ++S + ++ L ++ +E+ IK + + + + +
Sbjct: 2260 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2319
Query: 5566 FEAELKKLQAALEQA--QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ---- 5619
F+ +K L++ +++ + + P G L + L + L + P++Q V
Sbjct: 2320 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2379
Query: 5620 -LCQ--SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676
LC SA+ P +A++ A L + A+ + + + +
Sbjct: 2380 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG--LTSIKKDMTDISHGY 2437
Query: 5677 KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG----YQEQIASLNS--- 5729
+ L L++ E+ K S +Q+ Q + S + QK+ +Q+ A ++
Sbjct: 2438 EDLGLLLKDKIAELNTK---LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2494
Query: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA--GRCHTL-- 5785
K ++ K+ A + V +V+ L + +L E TP A M+T + L
Sbjct: 2495 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2554
Query: 5786 LSPVTEESGEEGTNSE--------------ISSPPACRSPSPVANTDASVNQDIAYYQAL 5831
L+ ++ EE +N+ + P++ +N Q L
Sbjct: 2555 LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2614
Query: 5832 SAERLQTDAAKIHPSTSASQEFYE-PGLEPSATA----KLGDLQRSWETLKNVISEKQRT 5886
E T + T+A Q PG +PS +L + + W++L +S++
Sbjct: 2615 LQE-FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2673
Query: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQ 5943
+ +A+ + +YQ L+S+S K+ ++ KLS S P++ Q+ Q + EI +
Sbjct: 2674 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2733
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
+I Q +L E+L + E +L+ Q L + + + KA Q L+
Sbjct: 2734 KQIKVAQ-ALCEDLSALVKEEYLKAELSRQ--LEGILKSFKDVEQKAENHVQHLQSACAS 2790
Query: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDM-----------EAQL 6052
+ Q+ + Q + E + A LD S K+ D E +
Sbjct: 2791 SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2850
Query: 6053 MDCQNMLVEIEQKVVALSELSVH---------------NENLL---LEGKAHTKDEAEQL 6094
+ +N+L++ + A +L ++ EN L LE K++ E L
Sbjct: 2851 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2910
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + + +L E++ L E E S L + Q Q +
Sbjct: 2911 WPWIDKCQNNLEEIKFCL---------DPAEGENSIAKLKSLQKEMDQHF---GMVELLN 2958
Query: 6155 QRQSSLQQQKELEQELA--EQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG 6212
+SL E+++E+ E KSL++ V E++ + E ++ +S+E
Sbjct: 2959 NTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-- 3016
Query: 6213 MEGEKSSAEDQMRMKWESLHQEFS--------TKQKLLQNVLEQ-------EQEQVLYSR 6257
+ + A++Q+ + Q +S T+QK LQ + Q Q+ V+ +
Sbjct: 3017 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEAS 3076
Query: 6258 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVS 6317
++ S V L + + Q+ S ++ +D +F E Q G H + + + S
Sbjct: 3077 DSKGTSDV-LLQVETIAQEHSTLSQQVDE-KCSFLETKLQGIG------HFQNTIREMFS 3128
Query: 6318 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL-----FSQA 6372
+ + D+++ + A + + ET +E + +K++ M N N A
Sbjct: 3129 QFAEFDDELD-----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3183
Query: 6373 FPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK---VLFTSL 6429
E + I+ L L + + L R Q++ ++++ F + LK +L
Sbjct: 3184 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3243
Query: 6430 ADNKYI---------ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
+++ + + N+F+ E+IE +Q + + G+I+ + Q
Sbjct: 3244 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3303
Query: 6481 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 6540
+ +L + + L + R + L + L +++ AL+ L + E++
Sbjct: 3304 GLE---HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM-VDTEELVA 3359
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 6600
+QK + + ++ + + K + L+ E + R+ A E +++ Q S
Sbjct: 3360 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3419
Query: 6601 -------AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR 6653
A+L +A R +LE I E + L+ L +E + + + +
Sbjct: 3420 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3479
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTN 6710
L ++I ++ L+ + + L+Q + G+ L + S D ++S+L+ ++
Sbjct: 3480 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539
Query: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE-----------FWTQQSVTVPQ 6759
K L+ L + + + +L++WL D+L W QQS
Sbjct: 3540 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS----- 3594
Query: 6760 ELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWT 6818
EL ++++ + L + VD L G +LL+ D ++ +L I +++
Sbjct: 3595 ELRVLQEDI---LLRKQNVD-------QALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3644
Query: 6819 D---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 6875
D L T++ E+ QL +L S H E+ +W+ +E + E +
Sbjct: 3645 DITKLSTDVAKTLEQALQLAR-RLHSTH--EELCTWLDKVEVELLSYETQV--------- 3692
Query: 6876 HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD------KTDFAEQLGAMN 6929
L+ + + + K+L + N L S +V S + + + + N
Sbjct: 3693 ---LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3749
Query: 6930 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK-------QQHRIGD 6982
+ ++++ +T+K++ ++ + +++ +W EK+L +Q +
Sbjct: 3750 ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3809
Query: 6983 QASVQNA-----LKDCQDLEDLIK---------------AKEKEVEKIEQNGLALIQNKK 7022
Q VQ L+ ++DL+K + +K+++K+ +N + Q
Sbjct: 3810 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3869
Query: 7023 EDVSSI--VMSTLRELGQTWANLDHMVGQLKILL--------------------KSVLDQ 7060
E + S + + +T+ L + + + ++ + + +
Sbjct: 3870 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3929
Query: 7061 WSSHKVAFDKINSYLMEARYSLSRFRLLTG---SLEAVQVQVDNL-QNLQDDLEKQERSL 7116
+ HK DK+N + L G S++ V D L +++D++K+ +L
Sbjct: 3930 IAEHKPHIDKMN------KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVAL 3983
Query: 7117 QKFGSITNQLLKECHPPVTETLTNTLKEVNM--RWNNLLEEIAEQLQSSKAL---LQLWQ 7171
+ S + Q + + E+L ++ + + +E+I EQ+ +K + ++ Q
Sbjct: 3984 DEAISQSTQFHDKI-DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQ 4042
Query: 7172 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATW-------------IQDCNDL 7218
+ KQ + + T++ + A +D D V W + D +L
Sbjct: 4043 PLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4102
Query: 7219 --------LKGLGTVKDSLFFLHELGEQ------LKQQVDASAASAIQSDQL-------- 7256
+ + T+KD+ F+ +L + +KQQ +A+ + D L
Sbjct: 4103 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4162
Query: 7257 SLSQHLCA-----------------------LEQALCKQQTSLQAGVLDYETFAKSLEAL 7293
+L L A L +A + L+ + + L+A+
Sbjct: 4163 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4222
Query: 7294 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYRLP 7350
W+ A L P +DL T+++++EELK + +++RLN EL +
Sbjct: 4223 FDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4281
Query: 7351 LNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7406
+ + +Q+ L W + + R KL+ LL F + + +L TE
Sbjct: 4282 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4341
Query: 7407 KLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 7464
L+ + + G+ + + + H + Q ++ + Q + ++ G L+E ++
Sbjct: 4342 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4401
Query: 7465 KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS--YLPMSGLGSV 7522
KL +L+ +WQ V+ + +QR+ +D +RQ + + E L++WL + L LG +
Sbjct: 4402 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4461
Query: 7523 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7582
P ++ + EV F ++ +Y ++ G+Q+L AE + ++ ++EK
Sbjct: 4462 PETAKEQLNVHMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEK 4518
Query: 7583 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS-QSLPDHHEELHAEQM 7641
W+S +L E+K KL L + + D + L ++ L+ S P + Q+
Sbjct: 4519 WESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQI 4578
Query: 7642 -RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7700
K N V S + + +L L + D+ ++ + +Q +WE++ +L R
Sbjct: 4579 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4638
Query: 7701 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEE 7754
+ + + F E +L EWL ES+ S + ++ I +K+K K++Q+
Sbjct: 4639 GRSLDDARKRAKQFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4696
Query: 7755 IAIAQENKIQLQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+ + G L K S +++ L ++ D+W + R KL+E L
Sbjct: 4697 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4756
Query: 7814 VAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ Q + +L WL +E +LA +P+ D + + ++ + Q+++ K ++
Sbjct: 4757 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD---IDLVMNLIDNHKAFQKELGKRTSS 4813
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
V ++ L+ + D+ +Q + L RW +CA+S+ ++ ++E R +
Sbjct: 4814 VQALKRSARELI---EGSRDDSSWVKVQM--QELSTRWETVCALSISKQTRLEAALRQAE 4868
Query: 7932 KFLDDYSRFEDWLKSSERTAAF----PSSSGVIYTVA---KEELKKFEAFQRQVHECLTQ 7984
+F +WL +E+T F P + T+ KE +KK E + ++++ T
Sbjct: 4869 EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4928
Query: 7985 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL-------QKRVTSILRRLKHFIG 8037
+ + DS ++K + R++ + Q+R+ S L L I
Sbjct: 4929 GDTV-------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL---IA 4978
Query: 8038 QREEFETARDSILVWLTEMDLQLTN-----IEHFSECDVQAKIKQLKAFQQEISLNHNKI 8092
++E E ++L WL + LT+ I E +V+A I + + F +E++ +
Sbjct: 4979 KQELLE----ALLAWLQWAETTLTDKDKEVIPQEIE-EVKALIAEHQTFMEEMTRKQPDV 5033
Query: 8093 EQI 8095
+++
Sbjct: 5034 DKV 5036
Score = 286 bits (731), Expect = 8e-76
Identities = 864/4710 (18%), Positives = 1776/4710 (37%), Gaps = 672/4710 (14%)
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA-KEFSDKCK 3811
+E G+ + LE +A LR E+ + +E L+++ + V+++ + E L LA K
Sbjct: 389 KEWGKLIIAMLEREKA--LRPEV-ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK 445
Query: 3812 ALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----KSLQQTVLSHEPSVKSVREKGE 3866
L + ++ +A+++ Y L+Q V+ + + + +
Sbjct: 446 RLESGVQ----------------FQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQAD 489
Query: 3867 ALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH 3926
L++ V L+D+I L+++ + S G+ + E + +I
Sbjct: 490 QLVQRV--AKLRDEIMALRNECSSVYSKGRILTTE-------------QTKLMISGITQS 534
Query: 3927 LQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 3986
L + Q +H L T+ M L + ++ T + S + P
Sbjct: 535 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 594
Query: 3987 DLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQT 4046
+ +P + + Q++ +K++ D TE+
Sbjct: 595 NFSSGVEPNSLQTLKLMQIR-----------------------KPLLKSSLLDQNLTEEE 631
Query: 4047 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH---SELELNIAQNMVSQ 4103
I K VQ +++ ++E L + L+N K H E E ++ + +S+
Sbjct: 632 INMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 691
Query: 4104 VK----------DFVKKLQSKQASV---------------NTIIEKVNKL---TKKEE-- 4133
++ + + +L+S+ A + N + N+L +KEE
Sbjct: 692 IQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 751
Query: 4134 -----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY--------HDCMNVVEV 4180
S + I D +L R+ + Q+EE+++ ++ H +E
Sbjct: 752 VAYDWSERNTNIARKKDYHAELMRELD----QKEENIKSVQEIAEQLLLENHPARLTIEA 807
Query: 4181 FLEKFTTEWDNLAR-------------------SDAESTAVHLEALKKLALALQ-----E 4216
+ T+W + + +DA+ +L LK A+Q +
Sbjct: 808 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCD 864
Query: 4217 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI----------- 4265
R +I L+D Q+ +E +KE + + S + + + +I+ K
Sbjct: 865 RSSSIHKLEDLVQESME-----EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 919
Query: 4266 ---------QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQS-----PPP----- 4306
Q+ +T ++ V + +W + P EA+ S PPP
Sbjct: 920 PIKAICDYRQIEITIYKDDECVLANNSHRAKW-KVISPTGNEAMVPSVCFTVPPPNKEAV 978
Query: 4307 DMAQNLLMDHLAICSELEAKQMLLKS------LIKDADRVMADLGLNERQVIQKALSDAQ 4360
D+A + + + + + +KS LI + DR+ A + + ++
Sbjct: 979 DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPG------ 1032
Query: 4361 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4420
H LS+L + +L S+++Q VF + Q + K
Sbjct: 1033 EHQQVLSNLQSRFEDFLED--SQESQ----VFSGSDITQ------------------LEK 1068
Query: 4421 QVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCS 4480
+V CK + YQ EL+K +E+ E + ++Y S ++
Sbjct: 1069 EVNVCK------QYYQ-----------ELLKSAEREEQEE------SVYNLYISEVRNIR 1105
Query: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540
RL+ E L+ + + D L ++ + L E L L N E+
Sbjct: 1106 LRLENCEDRLIRQIRTPLERDD----LHESVFRITEQEKLKKELERLKDDLGTITNKCEE 1161
Query: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK---DKFYKVQE 4597
Q + +P+L +LN + + N + +++ DK V
Sbjct: 1162 --------FFSQAAASSSVPTLRS--------ELNVVLQNMNQVYSMSSTYIDKLKTVNL 1205
Query: 4598 AILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGE 4657
+ + +L++L L E EA + + E +S R+ +DE +
Sbjct: 1206 VLKNTQAAEALVKLYETKLCEEEAVIADKNNI------ENLISTLKQWRSEVDEKRQVFH 1259
Query: 4658 AVDELNQKKEGF----------RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707
A+++ QK + R W +K LV + + Q + R+ LE
Sbjct: 1260 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1319
Query: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767
+ + + L+ ++ V+ Q K+ +E P K +LA L +++ + +
Sbjct: 1320 SLKYYRDTYHPLDDWIQQVETTQRKI-QENQPENSK-----TLATQLNQQKMLVSEIEMK 1373
Query: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4827
+ +K Q + + +L T V + V+ Q+ +
Sbjct: 1374 QSKMDE------CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1427
Query: 4828 WLRRVKAELSGPVYLDL--------NLQDIQEEIRKIQIHQEE-VQSSLRIMNALSH--- 4875
++ + V L +L+ ++EE + ++ ++E V+ + + +S+
Sbjct: 1428 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1487
Query: 4876 --KEKEKFTK---AKELISADLEHSLAELSELDGDIQEALRTRQATLT--------EIYS 4922
K+ EK K +K+ IS++ E+S + EAL+T Q L E +
Sbjct: 1488 TLKDAEKAGKPPFSKQKISSE------EISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1541
Query: 4923 QCQRYYQVFQAANDWL-EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL--E 4979
+ ++ + Q + + L ++ + LQ + DV+ E+ + + + + Q +L +
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601
Query: 4980 ELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR 5039
+ L+ + + G +L++ + + + + +D L ++ K
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKK----YQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1657
Query: 5040 EEVIELMNDT--EKKLSEFSLLKTSSSHEAEEKLSE-HKALVSVVNSFHEKIVA---LEE 5093
E + + E+KL+E + + +AE+ E K + + + EK+ A LEE
Sbjct: 1658 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1717
Query: 5094 KASQLEK-------TGNDASKATLSRSMT-----TVWQRWTRLRAVAQDQE---KILEDA 5138
+++E D+ +A T +Q A+ ++ E +LE
Sbjct: 1718 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1777
Query: 5139 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5198
VD +V E ++Q K+ KA+ ++ H ++ QSA
Sbjct: 1778 VD------GQVGTTQENLNQQYQKV---------KAQHEKIISQHQAVIIAT---QSAQV 1819
Query: 5199 MLRQQTLSMLQDGAAPTPGEEPPL---MQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5255
+L +Q G +P E+ L M+E+ + L EK +++EL E
Sbjct: 1820 LLEKQ-------GQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---E 1869
Query: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL 5315
+ + W+Q++++ L N ++A +++ L+T+ + E + + + L
Sbjct: 1870 KFDADYTEFEHWLQQSEQELEN----LEAGADDINGLMTKLKRQKSFSEDVISHKGD--L 1923
Query: 5316 GLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILT 5375
TI + ++ E A RD +V+ S AT +E+ R++ ++ +
Sbjct: 1924 RYITISGN----RVLEAAKSCSKRDG-----GKVDTS-ATHREVQRKLDHATDRFRSLYS 1973
Query: 5376 KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435
K +N+ + + G + L +A K L + + ++ + T+
Sbjct: 1974 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2033
Query: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495
Q I + + KL + A L + L I+K G S S + E+
Sbjct: 2034 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS-VNERN 2092
Query: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5555
Q L S + L+ M L ++ +V + K QV + L+ +I +
Sbjct: 2093 EKLQITLTRSLSVQDGLDEM---LDWMGNVESSLKEQGQVP---LNSTALQDIISKNIML 2146
Query: 5556 LQDAAKDMKKFEAELKKLQAALEQAQ-ATLTSPEVGRLSLKEQLSHRQH----LLSEMES 5610
QD A A +K++ +E +T +S + L + S H L++ME
Sbjct: 2147 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2206
Query: 5611 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5670
LK KV+ + + E + L AL + + T + Q MQ + ++
Sbjct: 2207 LKTKVELFE------NLSEKLQTFLETKTQALT-EVDVPGKDVTELSQ--YMQESTSEFL 2257
Query: 5671 QYEQEMKHLQQLIE--GAHREIEDKPVATSNIQELQAQISRHE----ELAQKIKGYQEQI 5724
++++ ++ L L++ +H DK + L + E E + + QEQ+
Sbjct: 2258 EHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2317
Query: 5725 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 5784
+ K L K T + + + + G EDL L T + T
Sbjct: 2318 DAFQVLVKSLKSWIKETTKKVPIVQP---SFGAEDLGKSLEDTKKLQEKWSLKTP----- 2369
Query: 5785 LLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIH 5844
++ NS IS + + A A+V A L+ E T+
Sbjct: 2370 --------EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA---VLNGEGTATN----- 2413
Query: 5845 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5904
++EF+ S + D+ +E L ++ +K L L + QK Q+ ++
Sbjct: 2414 -----TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2468
Query: 5905 ST---KMEAIELKLSESPEPG--RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
KM K ++P P + ++Q+ ++++ E+ +++ EL+ L E L+
Sbjct: 2469 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE-LLE 2527
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRC 6019
E+ D E + LT + + + ++Q LEE N+ + Q E L++
Sbjct: 2528 EN--PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ--- 2582
Query: 6020 EADELDSWLLSTKATLDTALSPPK-EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
WL+ K + + L P +P + Q Q +L E + +L+ +
Sbjct: 2583 -------WLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2634
Query: 6079 LLLEG------KAHTKDEAEQLAGKLRRLKGSLLEL-----QRALHDKQLNMQGTAQEKE 6127
+L + K++ + K L G L + Q + Q + +
Sbjct: 2635 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2694
Query: 6128 ESDVDLTATQSPGVQ---EWLAQARTTWTQQRQSSLQQQKELE--QELAEQKSLLRSVAS 6182
SD+D + S V + + Q T + +Q Q++K+++ Q L E S L
Sbjct: 2695 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2754
Query: 6183 RGEEILIQ-HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR---MKWESLHQE---- 6234
E+ Q ++ D +K + Q L S QM W +E
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2814
Query: 6235 ---FSTKQKLLQNVLEQEQ-------------EQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S K +L+++++ + E+ + N LL K + Q +
Sbjct: 2815 SHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2874
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLF-VATALL 6337
T+ D N+ +E ++ ++S+ K + V W+D + L + L
Sbjct: 2875 IKTNW-DTFNKQVKERENKL----KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2929
Query: 6338 PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL 6397
P E E + + L K++ + ++ N + +++V+ D L+ ++ ++
Sbjct: 2930 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2989
Query: 6398 DSVVNQRCHQMKERLQQILNFQNDLKV-----------------LFTSLADNKYIILQKL 6440
++ + ++ Q+ FQ K L + NKY+ + +
Sbjct: 2990 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3049
Query: 6441 ANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 6499
Q + Q++ ++ A+D + E + K D L + QE S L DE
Sbjct: 3050 QQKSLQALKHQVDLAKRLAQDLVVEAS----DSKGTSDVLLQVETIAQEHSTLSQQVDEK 3105
Query: 6500 MMIIGSRRSGL----NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL 6555
+ ++ G+ N + SQ+ +L + G+ D + + KE I+
Sbjct: 3106 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-----DAETLQKQKETIKAF 3160
Query: 6556 LDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR 6609
L K + ++ M+ TE ++ E L Q + +L RA R
Sbjct: 3161 LKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA-----LSKQCNKLLDRAQAR 3215
Query: 6610 GVELEYIL----ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665
++E + E +S L E L + E ES P VG+ E ++ ++ ++Q K
Sbjct: 3216 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGP-VGMETETINQQLNMFKVFQ--K 3272
Query: 6666 SSLNEYQPKLYQVLDDGKRLLISI----SCSDLESQLNQLGECWLSNTNKMSKELHRLET 6721
+ Q K V G+ L+ S S LE L+ + W + K+++ +L+
Sbjct: 3273 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3332
Query: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
L H R+Q L+ W+ ++ + S E ++V+ + + +D +
Sbjct: 3333 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVKAQIQEQKLLQRLLDDR 3388
Query: 6782 SSLKSSVLSTGNQLLRLKK-VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
S + G ++ + D + +LS +DS+W LL +L + +
Sbjct: 3389 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3448
Query: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDI---NCKQLT 6895
+ + W++ +E + E IG +A + E + ++K + DI N
Sbjct: 3449 FHETLEPLNEWLTTIEKRLVNCEP-----IGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3503
Query: 6896 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQI-LQGLVTEKIQLLEGLLESWS 6954
+ QS+ +SS++ + K DF++ W I +Q + +LL+ L +
Sbjct: 3504 AVSIGQSLKVLSSREDKDMVQSKLDFSQV-------WYIEIQEKSHSRSELLQQALCNAK 3556
Query: 6955 EY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013
+ E+ V+ + E +K K + + + + L++ I +++ V++ N
Sbjct: 3557 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3616
Query: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073
GL L++ D I+ L + + ++ + + L+ L +++ +
Sbjct: 3617 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3676
Query: 7074 YLMEARYSLSRF--RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
+L + L + ++L G EA Q Q+ + L+ + + + L +++ LL+
Sbjct: 3677 WLDKVEVELLSYETQVLKGE-EASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLELVP 3734
Query: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
E L + E N R+ + + I ++++ A + Q++ + S + + E +
Sbjct: 3735 WRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL 3794
Query: 7192 NELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAI 7251
L +D ++ ++L+ + D + H++ ++ S +
Sbjct: 3795 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3854
Query: 7252 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 7311
L +C + Q Q+ V F ++ E L W+ E + I+ Q P+
Sbjct: 3855 DK-VLKNYDTICQINSERYLQLERAQSLV---NQFWETYEELWPWLTETQSIIS-QLPAP 3909
Query: 7312 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-PLNDKEIKRMQN----LNRHW 7366
+ + T++++ EE + + P +D++N+ G +L L+ E +Q + +
Sbjct: 3910 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY 3969
Query: 7367 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQR 7424
S I +R L + Q F +K + +E L + ++L IS + + EQ
Sbjct: 3970 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQIS 4029
Query: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRA 7480
++ +M Q + ++ G+ ++ + D+D KL + W+ +
Sbjct: 4030 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4089
Query: 7481 QQRRG----IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ--ARTLFD 7534
++R +++ + W + + ++ + L G+ + QQ A T+ +
Sbjct: 4090 EEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4149
Query: 7535 EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQK 7594
E+ Q + + G +L+ + + ++ + E+ W S + +++
Sbjct: 4150 EID-------GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4202
Query: 7595 KKLAFLLK-------------DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE---ELHA 7638
KL ++ DW G S+ + T + + Q + + + E +
Sbjct: 4203 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4262
Query: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
+Q+ + L + Q LL L D + + + L+ W+ L ++
Sbjct: 4263 QQIEMERLNH----------QAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERII 4309
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN----GDILIEEMIEKLKKDYQEE 7754
R+ ++ L F EL WLT E +S+ GD E IE K +
Sbjct: 4310 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE-IELAKHHVLQN 4368
Query: 7755 IAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+A ++ ++ + + G L ++S +AS ++ KL +N RWQ++L+ R ++L L
Sbjct: 4369 DVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4428
Query: 7814 VAVQQLDKNMSSLRTWLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ + L+ WL E L +KP+ E + +LN E+ E
Sbjct: 4429 RQAKGFHGEIEDLQQWLTDTERHLLASKPL---GGLPETAKEQLNVHMEVCAAFEAKEET 4485
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
S++ + +L C A +I Q NL +W ++ ER+ K+EE L
Sbjct: 4486 YKSLMQKGQQMLARCPKSAET----NIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4541
Query: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
+F + F +WL +E+T S +I ++ + + F +V+ Q+ ++K
Sbjct: 4542 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4601
Query: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
L ++ +K ++ RW+ + +R+ R L + ++F A ++
Sbjct: 4602 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4661
Query: 8052 WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL 8109
WL E + L + +E ++ D ++ ++ Q K FQ+ + H+ + G L EK+
Sbjct: 4662 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4721
Query: 8110 DAAI-IEEELDELRRYCQEVFGR-VERYHK 8137
D + +++ L ELR + G+ VER +K
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNK 4751
Score = 278 bits (712), Expect = 1e-73
Identities = 768/4289 (17%), Positives = 1650/4289 (38%), Gaps = 539/4289 (12%)
Query: 1285 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1344
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1034 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1093
Query: 1345 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1394
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1094 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1150
Query: 1395 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1454
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1151 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1209
Query: 1455 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1514
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1210 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1265
Query: 1515 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1547
Q S F T E +I +L + G+ L+ +
Sbjct: 1266 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1325
Query: 1548 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1604
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1326 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1378
Query: 1605 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664
CQ SA K + A QQ + RR Q++ + ++ +
Sbjct: 1379 ECQKYAEQYSATV-------KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEF 1429
Query: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEVVSQASFYSKL 1723
L ++ +T + + + + D +K +E E + ++ + E V +A K
Sbjct: 1430 MDLRTRYTALVTLM--------TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA----KE 1477
Query: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
LQ S S KD K K P ++I+ + + + +Q E L +
Sbjct: 1478 LQKWVSNISKTLKDAEKAGK-------------PPFSKQKIS-SEEISTKKEQLSEALQT 1523
Query: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
I+LFL+ +H D + E + EL+ L + +L +
Sbjct: 1524 ----IQLFLA------------------KHGDKMTDEE--RNELEKQVKTLQESYNLLFS 1559
Query: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNS 1903
E L LQ +++ + E V ER+Q + L GI L QT
Sbjct: 1560 ESLKQLQ-ESQTSGDVKVEEKIVAERQQ----------EYKEKLQGICDLLTQT------ 1602
Query: 1904 MNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLC 1963
E+ LI Q A + V L SK + E + + +A L
Sbjct: 1603 ----ENRLI------GHQEAFMIGDGTVELKKYQSKQE--------ELQKDMQGSAQALA 1644
Query: 1964 GEVERIQNLL---GTKQSEADALAVLKKAFQDQK---EELLKSIEDIEERTDK---ERLK 2014
V+ +N L G K S+ D A++++ + K E+L E ++ DK +K
Sbjct: 1645 EVVKNTENFLKENGEKLSQEDK-ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 1703
Query: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKD----------KAKQIAQKD-------- 2056
E T +++ QLE+ E+ L WL + K KQ+ +++
Sbjct: 1704 EET-----EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGD 1758
Query: 2057 --VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
A E + N LE D EN L ++YQ +K+ K++ +
Sbjct: 1759 GKSAIGEEDEVNGNLLETDVDGQVGTTQEN---------LNQQYQKVKAQHEKIISQHQA 1809
Query: 2115 VIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLD-NFTSKGKHLLSELKKIHSSDFSL 2173
VI+ + + + + + E K K+ K+L ++ + ++K HS L
Sbjct: 1810 VIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1868
Query: 2174 VKTDMEST-VDKWLDVSEKLEEN-----------MDRLRVSLSIWDDVLSTRDEIE--GW 2219
K D + T + WL SE+ EN M +L+ S +DV+S + ++
Sbjct: 1869 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1928
Query: 2220 SNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETP 2278
S N V + A++ S D + +E + ++ + R L+SK N L K
Sbjct: 1929 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----- 1983
Query: 2279 PDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA 2338
DL+ K +H + + + G L A K +++ K
Sbjct: 1984 --------DLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPIAVDPK--------- 2023
Query: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQENLNSL--CRKYHSAELESLGRAMTGLIKKH 2396
L++ K +Q ++ SQQ + ++ L R + + + ++ ++
Sbjct: 2024 --NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2081
Query: 2397 EAVSQLCSKTQASLQESLEKHFS--ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
E +S+ ++ LQ +L + S + + E +W +++ KE +S L+ +
Sbjct: 2082 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2141
Query: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
+ ++ QS ++A+ ++ + SS+Q ++ + F + +
Sbjct: 2142 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2201
Query: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----ENLGESKQHIPEKKNEV--HKV 2567
+++ +++ FE+ KL ++ + +++ E Q++ E +E HK
Sbjct: 2202 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2261
Query: 2568 EM-FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSC 2626
+ L LL S S + +L + + S+ ++ ++ KE + SC
Sbjct: 2262 HLEVLHSLLKEISSHGLPSDKALVLEKTNN--------LSKKFKEMEDTIKEKKEAVTSC 2313
Query: 2627 QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGE 2683
Q L + L ++L+S W+K ++ + + G++D L K L ++Q+ +K
Sbjct: 2314 QEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAED-LGKSLEDTKKLQEKWSLKTP 2369
Query: 2684 GEVKLN----------MAIGKGEQALRSSNKEGQRVIQTQ--LETLKEVWADIMSSSVHA 2731
K+N A+ +A+ ++ K G V+ + +E WA+ +S+
Sbjct: 2370 EIQKVNNSGISLCNLISAVTTPAKAI-AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2428
Query: 2732 QST-------------------LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ-PQP 2771
T L + +S+ E + + QW++ +++ Q P P
Sbjct: 2429 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2488
Query: 2772 GLKEKF-VLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE---ELKTQ 2827
E ++ +S +E + + + L K EL E+ D ++ E+ ++
Sbjct: 2489 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2548
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
+ ++ + ++ +K+EE + + + WL + + +S D + +
Sbjct: 2549 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2608
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTA-SGCELMHTEMQALRADWKQWEDSVFQ 2946
+++ L L + P+ +Q T A G E +LR K+ +V Q
Sbjct: 2609 QQVQIL----------LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2658
Query: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSALLKTWAQQLTLLEGKNTDEEIV 3003
L + S + ++QA+ Q+ +LL++ + +L+ L+ K + V
Sbjct: 2659 KWDSLTG----------QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2708
Query: 3004 ECWHKG-QEILDALQKAEPRTEDLKSQLNELCRFSRDLST----------YSGKVSGLIK 3052
+ L+ QK + + K Q+ DLS S ++ G++K
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2768
Query: 3053 EYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS 3110
+ + +A Q+ + +F++ RDFQ WL K K I + + +
Sbjct: 2769 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2828
Query: 3111 LQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQ 3170
++ ++F H +++GE L + +Q ++ K +W F+ + +
Sbjct: 2829 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2888
Query: 3171 KESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI 3230
+E+ L+ + ++ E + W+ K + + E L D KL+S+ +E+
Sbjct: 2889 RENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCL-DPAEGENSIAKLKSLQKEM 2947
Query: 3231 HCYEPQLNRLKEKAQQLW------------EGQAASKSFRHRVSQLSSQYLALSNLTKEK 3278
+ + L A L E ++ + QL S+ L N+T +K
Sbjct: 2948 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT-QK 3006
Query: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIH-MLDSYCHPTSDKSVLDSRTLKLEALL-SV 3336
+ E + KE D IH L S + ++L ++ L+AL V
Sbjct: 3007 FKEFQEVSKESKRQLQCAKEQLD-----IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV 3061
Query: 3337 KQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396
K + ++V +S +G + Q++++ ++L S LE L
Sbjct: 3062 DLAKRLAQDLVVEASDS-------KGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3114
Query: 3397 KWTSYQDGVR----QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSL 3452
+Q+ +R QF+ + D +++ + K T+ K L + S +
Sbjct: 3115 GIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNA 3174
Query: 3453 LETIEVKGAGMTEHYVTQL-----ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507
+T ++ A TE L +L+ L ++ + +RA+ + E ++ +E+
Sbjct: 3175 NKTCKMMLA--TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3232
Query: 3508 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE------------GQAL 3555
LK F + L + +E + + + T L + Q E GQ L
Sbjct: 3233 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3292
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ S S Q + L+ + W+ ++++ Q + + +
Sbjct: 3293 IQS-------AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3345
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
+ W+ EE +++ + +V + + Q++L + + + + A
Sbjct: 3346 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATT 3405
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
+ +++K L +++ L+ +L + ++ + VA + +TL
Sbjct: 3406 AEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-----------ETL 3453
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEE-GEAERLRKEIHDHMEQLKELTSTVRKEHM 3794
E L + + L + G +A K E+ + + L +I +H + L H
Sbjct: 3454 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL----------HQ 3503
Query: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3854
+ G L S + K + Q ++ ++ ++ E+ EK S+ + LQQ +
Sbjct: 3504 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI------EIQEKSH--SRSELLQQALC-- 3553
Query: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG--------KAMMEEIAGFE 3906
+ K E L+ + +V DK+ +L QD + G + + E+I +
Sbjct: 3554 --NAKIFGEDEVELMNWLNEV--HDKLSKL--SVQDYSTEGLWKQQSELRVLQEDILLRK 3607
Query: 3907 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 3966
++ + G L+ Q ++ + A KD A+ + Q+L+ +
Sbjct: 3608 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3667
Query: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4026
H T ++ WL V+ +L L EA + + L+++A+ LL S+
Sbjct: 3668 H----STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3723
Query: 4027 DLSNASVKTTAKDIQQ-----TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQ 4081
++S+A ++ ++ + E+ + + +TQ EEI + Q AD +
Sbjct: 3724 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3783
Query: 4082 L----QNMKRRHSELELNIAQNMVS---QV-KDFVKKLQSKQASVNTIIEKVNKL----T 4129
L + K+ S ++ + Q+ S QV K F ++ + ++ +++ +K+ +
Sbjct: 3784 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3843
Query: 4130 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4189
++E+ K+++ + + +C+ ++ LQ E ++V F E + W
Sbjct: 3844 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLER----------AQSLVNQFWETYEELW 3893
Query: 4190 DNLARSDAESTAVHLEALKKLALALQERKY-AIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248
L + + + + AL+ L Q+ ++ + +L + + I+ +N +L++
Sbjct: 3894 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3953
Query: 4249 H---LEQRWFQLEDL---IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302
+++++ + L IK ++ L+E ++F + ++ E I E L+Q
Sbjct: 3954 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4013
Query: 4303 SP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
P + + + ++ + ++E Q L ++L + + ++A G ++ + KA+ D
Sbjct: 4014 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4073
Query: 4359 AQSHV----NCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
+ + LV +R L + +F I+ + I E +
Sbjct: 4074 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4133
Query: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
P V +Q + ++ + + Q E+ + G EL+ E +K V + EL S +DS
Sbjct: 4134 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4193
Query: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT---QL 4531
+ + R+ +LE+ + + +++ W+ DI ++ ++L T Q+
Sbjct: 4194 LNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV---DIAGGKLASMSPIGTDLETVKQQI 4250
Query: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKD 4590
+ + ++ + + + L + +L + E D + + L L ++ + +
Sbjct: 4251 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4310
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD-LAVEEALS----LQDGC 4645
+ +K++ A+LA ++ ++ L+ E V D A+E L+ LQ+
Sbjct: 4311 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
A V + +A ++L + G ++ +K+ L + + +TEQR L+
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4427
Query: 4706 TSAYQEHEKMCQQLERQLKSVKEE---QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK 4762
+ + L++ L + + A+E+L ++ + + + K
Sbjct: 4428 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4487
Query: 4763 RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEM 4822
+ + + A I + + + + + + + E T+ E + +++F +
Sbjct: 4488 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4547
Query: 4823 SRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEK 4880
++WL + + L+ L L + +I + ++ EV S + L + +
Sbjct: 4548 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4607
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
F++ ++++ +++ L + + + L R +L + + +++++ + +WLE+
Sbjct: 4608 FSQKQDVVL--IKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4665
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTG 4996
+++ L + L++ + + +K+ + + +F +L HS+ T + L + T
Sbjct: 4666 SEKSLD---SELEIANDPDKIKTQL---AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTS 4719
Query: 4997 KED----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKK 5052
D L+ ++ L + + S + + L+ + A + +I+ + E +
Sbjct: 4720 LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ 4779
Query: 5053 LSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSR 5112
L+E + + HKA + + AL+ A +L + D S + +
Sbjct: 4780 LAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKV 4837
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
M + RW + A++ ++ LE A+ + F++ V E + + + L
Sbjct: 4838 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4897
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
+ L TL++ H F+ +LE++++ L ++L A P + IT ++ R
Sbjct: 4898 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL---AICHPDSITTIKHWITIIRAR 4954
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ--------ETKEYLGNPTIEIDA 5284
+ K + + + L + + ++ W+Q + KE + E+ A
Sbjct: 4955 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5014
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEK 5313
+ E Q + E T + +++K+ + K +
Sbjct: 5015 LIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5043
Score = 276 bits (707), Expect = 5e-73
Identities = 777/4352 (17%), Positives = 1650/4352 (37%), Gaps = 709/4352 (16%)
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQ----ADEMDRMKKEYTDCVVTL-----SAFATEAHK 736
++QQ + W E + +K +E+DR++ + T+ +
Sbjct: 984 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1043
Query: 737 KLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
+ + LE S + D+ +E+ V V Y+ + K+A +E +E ++ +
Sbjct: 1044 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE---REEQEESVYNLY--I 1098
Query: 797 SKLKEQLTKVKECYSPL------------LYESQQLLIPLEELEKQMTSFYDSLGKINEI 844
S+++ +++ C L L+ES + E+L+K++ D LG I
Sbjct: 1099 SEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNK 1158
Query: 845 ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD---- 900
+A +S+ EL +N + ++ S + K T++ VLK+
Sbjct: 1159 CEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSM---SSTYIDKLKTVNLVLKNTQAAEA 1215
Query: 901 -----QTRLQRQ---IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRI 952
+T+L + IAD + ++++ W+ V+ ++ E+ EL+K I
Sbjct: 1216 LVKLYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALED---ELQKAKAI 1271
Query: 953 AQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDI--------LPEQEQQGL 1004
+ E + + + H E QL +R N ++ + L D+ L
Sbjct: 1272 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPL 1331
Query: 1005 QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLAS-VEECRTELDRETKLMPQEGS-- 1061
+ ++++ + +Q P + L + + + L S +E ++++D K Q +
Sbjct: 1332 DDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV 1391
Query: 1062 ---EKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVK--LPVRDPVRDTPGTCHVTL--KE 1114
E +R + + +R+Q +L ++ + +R T T VTL +
Sbjct: 1392 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR-----TRYTALVTLMTQY 1446
Query: 1115 LRAAIDSTYRKLMEDP---DKWKDYTSRFSEFSSWISTNETQLKG-------------IK 1158
++ A DS R E+ ++ K++ + E W+S LK I
Sbjct: 1447 IKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1506
Query: 1159 GEAIDT----------------ANHGEVKRAVEEIRNGVTKRGETLS-----WLKSRLKV 1197
E I T A HG+ + +E RN + K+ +TL LK
Sbjct: 1507 SEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERNELEKQVKTLQESYNLLFSESLKQ 1564
Query: 1198 LTEVSSENEAQKQGDELAKLSSSFK----ALVTLLSEVEKMLSNF--------------- 1238
L E + + + + +A+ +K + LL++ E L
Sbjct: 1565 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKK 1624
Query: 1239 -------------GDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEA----QQL 1281
G E+VKN+ E + + E Q +K L + L EA +QL
Sbjct: 1625 YQSKQEELQKDMQGSAQALAEVVKNT-ENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1683
Query: 1282 LLHHQQKTKR----ISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRER 1337
L +Q K ++ ++ +++A +Q E E K+E+ LD L +
Sbjct: 1684 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE--------ESKTKIENLLDWLSNVDKD 1735
Query: 1338 QER----RIQVTLRKWERFETN--------KETVVRYLFQTGSSHERFLSFSSLESLSSE 1385
ER QV + F+ ++ V L +T + ++ E+L+ +
Sbjct: 1736 SERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ---VGTTQENLNQQ 1792
Query: 1386 LEQTKEFSKRTES------IAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439
++ K ++ S IA Q+ ++ E L P+ K+ LQ+ K +K +
Sbjct: 1793 YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1852
Query: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK----- 1494
E+ +K ++ + + F +++ W+ + E+EL LE + ++ ++++K
Sbjct: 1853 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1912
Query: 1495 ---VTIQEIESKLSSIVG--LEEEAQSFA-----QFVTTGESARIKAKLTQIRRYGEELR 1544
V + + + +I G + E A+S + + T+ ++ KL L
Sbjct: 1913 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1972
Query: 1545 EHAQCLEGTILGHLSQQQKFEE-------NLRKIQQSVSE-FEDKLAVPIKICSSATETY 1596
L + + + Q +E+ L+ + + S+ + +AV K E
Sbjct: 1973 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEET 2032
Query: 1597 KVLQEHMDLCQ-ALESLSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQ 1654
K LQ + Q A+E L + ++ + +Q+ + +YED+ + ER
Sbjct: 2033 KALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERN 2092
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
L+ L ++ L L W+ E+ +K +G++ L +++
Sbjct: 2093 EKLQITLTRSLSVQDGLDEMLDWMGNVESS------------LKEQGQVPLNSTALQDII 2140
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKMMKL----HLEQLDERWRDLPQIINKRINFLQSV 1770
S+ + + ++S + ++ K M+ L + +DL ++ + +
Sbjct: 2141 SKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2200
Query: 1771 VAEHQQFD---ELLLSFSVWIKLFL-SELQTTSEISIMDHQVA-LTRH-KDHAAEVESKK 1824
+A+ ++ EL + S ++ FL ++ Q +E+ + V L+++ ++ +E K
Sbjct: 2201 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2260
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSH 1884
L+ L L ++ S G D L+ K + + F+E ++ ++ A++ E L +
Sbjct: 2261 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2320
Query: 1885 ASLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKALE--------------SA 1929
L ++ L+ + E T + + +DL +L++ K L+ ++
Sbjct: 2321 QVL---VKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2377
Query: 1930 AVSLDGILS------KAQYHLKIG-----------------SSEQRTSCRATADQLCGEV 1966
+SL ++S KA +K G +++ TS + +
Sbjct: 2378 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2437
Query: 1967 ERIQNLLGTKQSEADA-LAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPT-RQALQQ 2023
E + LL K +E + L+ L+KA Q++ +++ ++ + + K ++ PT +A++
Sbjct: 2438 EDLGLLLKDKIAELNTKLSKLQKA-QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2496
Query: 2024 RLRVFNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRLI 2081
++ E EL + +++ LKDK ++ ++ D AP + + ++ W + +L
Sbjct: 2497 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2556
Query: 2082 HENQGQCCGLIDLMREYQNLKSAVSK-VLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ Q + + + ++Q +++ + + ++E V V D L + +
Sbjct: 2557 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2616
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLR 2200
+ ++ + T+ G+ +LS + S +VK + + KW ++ +L + D +
Sbjct: 2617 EFATRKPQYEQLTAAGQGILSRPGE-DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWID 2675
Query: 2201 VSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE--------------ELLKE 2246
++ V ST+ + + + +++ +S+LDN L + E ++
Sbjct: 2676 QAI-----VKSTQYQ------SLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2724
Query: 2247 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLE----HAKEITEVA 2302
+ E++ + +++ + DL L K ++++A+L ++LE K++ + A
Sbjct: 2725 MKQEIQQEKKQIKVAQALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKA 2777
Query: 2303 KG---TLKDFTAQSTQVEKFINDITTWF-TKVEESLMN---CAQNETCEAL-KKVKDIQK 2354
+ L+ A S Q ++ D W TK EE + A+ + E+L K KD K
Sbjct: 2778 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2837
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
L +Q T +L K +E +L + + + ++ + + L+ESL
Sbjct: 2838 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2897
Query: 2415 EK--HFSESMQEFQEWFLGAKAAAKE----SSDRTGDSKVLEAKLHDLQNILDSVSDGQS 2468
EK + E ++ W + +E G++ + AKL LQ +D G
Sbjct: 2898 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI--AKLKSLQKEMDQ-HFGMV 2954
Query: 2469 KLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFE 2528
+L T + K++V+ + + ++ +Q K L++ + F+
Sbjct: 2955 ELLNNTANSLLSVCEIDKEVVTDENKSLI---QKVDMVTEQLHSKKFCLENMTQKFKEFQ 3011
Query: 2529 DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRG 2588
+ ++ + +E+ + + S+ + + + + L L + +L+Q
Sbjct: 3012 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3071
Query: 2589 QLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2648
+ + + G + H L + EK + LQ + ++ M+
Sbjct: 3072 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3131
Query: 2649 AIQDRLAC-------AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQA--- 2698
D L AE+ K+T++ L +++ ++ M + E +
Sbjct: 3132 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3191
Query: 2699 ------LRSSNKEGQRV----------IQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
L + +K+ ++ ++ ++ L+E ++ + S+ Q E SQ
Sbjct: 3192 VGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3251
Query: 2743 NDYVERKNQLEQW-MESVDQKIE-HPLQPQ--------PGLKE---KFVLLDHLQSILSE 2789
+E + +Q M V QK E PLQ + GL + K L+ L +
Sbjct: 3252 PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3311
Query: 2790 AEDHTRALHRLIA-KSRELYEK-TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE-EIV 2846
+ L++ +A ++ +L E F+D + L + VA +K E ++V
Sbjct: 3312 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3371
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKE--LIDSR------- 2897
K + + D S E + R + ++ K+ +K+ L+DSR
Sbjct: 3372 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3431
Query: 2898 -EIGASRLSRV--------ESLAPEVKQNTTAS----GCELMHTEMQALR---ADWKQWE 2941
E +L + E+L P + TT CE + T+ L A K E
Sbjct: 3432 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3491
Query: 2942 DSVFQTQSCLENLVS--------------QMALSEQEFSGQVAQLEQALEQFSALLKTWA 2987
D + L VS M S+ +FS QV +E + S ++
Sbjct: 3492 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS-QVWYIEIQEKSHS---RSEL 3547
Query: 2988 QQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR---TEDLKSQLNELCRFSRDL---- 3040
Q L K E+ VE + E+ D L K + TE L Q +EL D+
Sbjct: 3548 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3607
Query: 3041 ----------------------STYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ--QRF 3076
K+ + Y + ++ + EQ LQ +R
Sbjct: 3608 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3667
Query: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136
+ WL ++ E S + + +E E++N + L+ +
Sbjct: 3668 HSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3727
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
L L+ +G++ V E ++ + QK ++ ++ + F+ +A+ W+
Sbjct: 3728 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3787
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE------- 3249
++TEK +L L R EQ + + L+ + ++ R K+ L +
Sbjct: 3788 TETEK-------KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3840
Query: 3250 --GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3307
+ +S + ++ ++ Y + + E+ +L+R + NQF +EL W+T+
Sbjct: 3841 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3900
Query: 3308 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3367
++ P + L + + L + E + + + G +L+ + EG +IQ
Sbjct: 3901 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF-SIQ 3959
Query: 3368 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3427
++ + +++ + + L+ A+S+ T + D + Q L ER
Sbjct: 3960 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI----------LESLERIVE 4009
Query: 3428 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3487
LR ++ + + + E++ +E+ ++++ LQ Y +++R
Sbjct: 4010 RLRQPPSISAEVEKIKEQI-----------------SENKNVSVDMEKLQPLYETLKQRG 4052
Query: 3488 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHT----HETTLRDLQ 3543
+E + +S +D+ A V Q+KLDQ + + HT E L D+
Sbjct: 4053 EEMIARSGGT-------DKDISAKAV-----QDKLDQMVFIWENIHTLVEEREAKLLDVM 4100
Query: 3544 EL-QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
EL + + +L+ ++ T++ + P + ++ ++ + + + + + +
Sbjct: 4101 ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDI 4160
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC 3662
V+N E+ A E ++ ++ +DE
Sbjct: 4161 VIN-----------------------LGSELIAACGEPDK--PIVKKSIDE--------- 4186
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
L S + +L ++I LEE +Q+ + + L + DW +++
Sbjct: 4187 ----LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP---- 4238
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER----AVKYLEEGEAERLRKEIHDH 3778
+G L+T++ ++++++ S + + ER A L++ E + + D
Sbjct: 4239 -----IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP 4293
Query: 3779 MEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMEL 3834
+ +LK L + LE L +F L W+ + +L + +
Sbjct: 4294 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4353
Query: 3835 YEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL---VQDVTLKDKIDQLQSDYQDL 3891
+ +L+K+ LQ VL+H+ +V++V + G L+E + L++K++ L +Q++
Sbjct: 4354 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4413
Query: 3892 CSIGKAMMEEI-------AGFEDRLNNLQ------------------------------- 3913
+ +++ GF + +LQ
Sbjct: 4414 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4473
Query: 3914 -----------------MKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
KG ++ +C + + Q+++ K+ + ++ +
Sbjct: 4474 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN----NLKEKWESVETKLNER 4529
Query: 3957 YQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQAR 4016
LE L + ++LQ WL+ + L + +P L + Q+ + +
Sbjct: 4530 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN 4589
Query: 4017 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQ 4076
++ + + + D + +K ++ +Q I+ L+ Q+ WE++ E L
Sbjct: 4590 SHREQIIEL-DKTGTHLKYFSQ--KQDVVLIKNLLISVQS---RWEKVVQRLVERGRSLD 4643
Query: 4077 DADQQLQNMKRRHSEL-------------ELNIA------QNMVSQVKDFVKKLQSKQAS 4117
DA ++ + S+L EL IA + ++Q K+F K L +K +
Sbjct: 4644 DARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSV 4703
Query: 4118 VNTIIEKVNKLTKKEESPEHK-----EINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYH 4172
+T L +K + ++ L D+W +C +S + EE L + +
Sbjct: 4704 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4763
Query: 4173 DCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK 4230
D + + +L + + D D + ++ K L +R +++ LK ++
Sbjct: 4764 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4823
Query: 4231 MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAE 4290
+IE + DD VK Q L RW + L K L + S L+EW
Sbjct: 4824 LIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 4882
Query: 4291 EQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNE-- 4348
E + + D + L+ H +LE K+ L D V+A +
Sbjct: 4883 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSIT 4942
Query: 4349 ---------RQVIQKALSDAQSH----VNCLSDLVGQRR---------KYLNKALSEKTQ 4386
R ++ L+ A+ H + L+ L+ ++ ++ L++K +
Sbjct: 4943 TIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDK 5002
Query: 4387 FLM--AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEV----- 4439
++ + + + I +H+ F E + DV K KT K A + Q+ +
Sbjct: 5003 EVIPQEIEEVKALIAEHQ---TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDK 5059
Query: 4440 ----------TGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
+ L+ G + E + ++ K Q++ + +K + L LE+
Sbjct: 5060 GRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEE- 5118
Query: 4490 LVSRKHFKEDFD----KACHWL--KQADIVTF 4515
R+ DFD K W+ K++ ++ F
Sbjct: 5119 --LREFANFDFDIWRKKYMRWMNHKKSRVMDF 5148
Score = 270 bits (691), Expect = 4e-71
Identities = 840/4709 (17%), Positives = 1807/4709 (38%), Gaps = 678/4709 (14%)
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1434
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 658 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 713
Query: 1435 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1494
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 714 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 767
Query: 1495 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1548
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 768 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 824
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1603
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 825 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 880
Query: 1604 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1653
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 881 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 940
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1712
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 941 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 998
Query: 1713 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1761
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 999 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1050
Query: 1762 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1821
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1051 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1102
Query: 1822 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1880
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1103 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1162
Query: 1881 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1934
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1163 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1219
Query: 1935 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1991
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1220 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1262
Query: 1992 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2045
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1263 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1314
Query: 2046 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2101
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1315 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1369
Query: 2102 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1370 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1426
Query: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1427 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1482
Query: 2221 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2267
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1483 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1542
Query: 2268 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2327
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1543 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1599
Query: 2328 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2383
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1600 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1659
Query: 2384 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2437
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1660 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1718
Query: 2438 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2464
+ S+R G +V+E Q N+L++
Sbjct: 1719 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1778
Query: 2465 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2494
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1779 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1838
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1839 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1896
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2612
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1897 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1947
Query: 2613 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2668
+ +E R A +L + +K + D+ E L E
Sbjct: 1948 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2007
Query: 2669 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 2008 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2067
Query: 2729 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2068 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2124
Query: 2789 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2825
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2125 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2184
Query: 2826 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2881
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2185 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2244
Query: 2882 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2941
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2245 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2300
Query: 2942 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2980
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2301 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2358
Query: 2981 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2359 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2417
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2418 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2471
Query: 3087 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3143
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2472 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2531
Query: 3144 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3203
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2532 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2591
Query: 3204 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3259
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2592 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2651
Query: 3260 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3319
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2652 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2711
Query: 3320 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3378
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2712 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2771
Query: 3379 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3438
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2772 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2831
Query: 3439 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3492
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2832 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2891
Query: 3493 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ--YSVLEGDAHTHETTLRDLQ-ELQVHC 3549
K ++ + +Y+ ++ W+ + Q L++ + + + L+ LQ E+ H
Sbjct: 2892 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2951
Query: 3550 AEGQALLN------SVLHTREDVIPS---GIPQAEDRA----------LESLRQDWQAYQ 3590
+ L N SV ++V+ + Q D LE++ Q ++ +Q
Sbjct: 2952 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3011
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQV--DEWLKTAEEKKWHEEVTAYRDEVEEVGARAQ 3648
E++ Q +L + + Q +++L + ++ + + A + +V+ AQ
Sbjct: 3012 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ--KSLQALKHQVDLAKRLAQ 3069
Query: 3649 EILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3705
+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3070 DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3129
Query: 3706 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3765
+ ++A +T+ K+ +T++ LK +E L ++ + + K +
Sbjct: 3130 FAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKTCKMMLA 3183
Query: 3766 GEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEY 3820
E +++++ +Q +L + +E + +EF K K + + +
Sbjct: 3184 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3243
Query: 3821 QEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK 3880
+E ME QL+ +K Q K++
Sbjct: 3244 EEHEESQGPVGMETETINQQLNMFKVFQ-----------------------------KEE 3274
Query: 3881 IDQLQSDYQDLCSIGKAMMEEIA------GFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 3934
I+ LQ QD+ +G+ +++ A G E L+++ + TL +
Sbjct: 3275 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK------------ 3322
Query: 3935 VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSR-QDTLQQCQAWLSAVQPDLEPSPQ 3993
AQR Q E L H R QD L+ +W+ + +L + +
Sbjct: 3323 -----------------VAQRAAQLQEALL--HCGRFQDALESLLSWMVDTE-ELVANQK 3362
Query: 3994 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK--- 4050
PP + + +K +QEQ LL + D ++V+ ++ ++ T E
Sbjct: 3363 PPSAEFKVVKA-----QIQEQK-----LLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412
Query: 4051 --LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM----KRRHSELELNIAQNMVSQV 4104
L Q L WE + + K+E ++QL+ + ++ H LE +
Sbjct: 3413 KILKQLSLLDSRWEALLN-KAET------RNRQLEGISVVAQQFHETLE---------PL 3456
Query: 4105 KDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4164
+++ ++ + + I + +KL +E+ +HK + ++
Sbjct: 3457 NEWLTTIEKRLVNCEPIGTQASKL--EEQIAQHKALE--------------------DDI 3494
Query: 4165 LQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ + H +++ + + E ++ +S + + V + +QE+ ++ +L
Sbjct: 3495 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY-------IEIQEKSHSRSEL 3547
Query: 4225 KDQKQKMIEHLNLDDKEL------VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVV 4278
Q + D+ EL V ++ S L + + E L K++ ++ V + L
Sbjct: 3548 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3607
Query: 4279 QSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDAD 4338
Q+ Q L+ N E LKQ+ ++ L I +LEA +K+ KD
Sbjct: 3608 QNVDQALL--------NGLELLKQTTGDEV--------LIIQDKLEA----IKARYKDIT 3647
Query: 4339 RVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQI 4398
++ D+ Q +Q A +H +L K + LS +TQ L + SQ
Sbjct: 3648 KLSTDVAKTLEQALQLARRLHSTH----EELCTWLDKVEVELLSYETQVLKG--EEASQA 3701
Query: 4399 QQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL--WAQGRELMKEVTEQ 4456
Q P ++ K+ K K+ SL + + L W L K V E
Sbjct: 3702 QMR-------------PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED 3748
Query: 4457 EKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD--IVT 4514
+ + V D++ QK ++E++ ++ + F + D W+ + + +++
Sbjct: 3749 N--------ERYRLVSDTITQK----VEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3796
Query: 4515 FPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKL 4574
+I L E + QL + + +++++ L ++G I+ + +E + + +KL
Sbjct: 3797 LGDIRL--EQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3854
Query: 4575 NALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLA 4634
+ + + ++ I + +++ +++ A ++ E L+E ++ +S++P
Sbjct: 3855 DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI---ISQLPAPAL 3911
Query: 4635 VEEAL-SLQDGCRAILDEVAGLGEAVDELNQKKEGFR--STGQPWQ-PDKMLHLVTLYHR 4690
E L Q+ R + + +A +D++N+ S G+ + +K + TLY +
Sbjct: 3912 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3971
Query: 4691 LKRQTEQRVSLLEDTTS-AYQEHEKMCQ---QLERQLKSVKEEQSKVNEETLPAEEKLKM 4746
+K ++R L++ S + Q H+K+ Q LER ++ +++ S ++ E +E++
Sbjct: 3972 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPS-ISAEVEKIKEQISE 4030
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+++ ++ + + + E++ + + +Q ++ + I V
Sbjct: 4031 NKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVE 4090
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQI-------- 4858
E E++++ ++ + W + L + ++D Q+ IR ++
Sbjct: 4091 EREAKLLDVMELAEKF-----WCDHMS--------LIVTIKDTQDFIRDLEDPGIDPSVV 4137
Query: 4859 --HQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELSELDGDIQEA 4909
QE ++ ++ L + ELI+A ++ S+ EL+ + +A
Sbjct: 4138 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4197
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEENLKSHMEFF 4968
+ R L E +Y QA DW++ A +L ++ G D+E+ ++ ++ +F
Sbjct: 4198 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4257
Query: 4969 STEDQFHSNLEEL-HSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027
S Q +E L H L + + + K ++ + L+L + + L+
Sbjct: 4258 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4317
Query: 5028 CTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 5087
+Q A +E++ + TE LSE + E +L++H L + V +
Sbjct: 4318 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVG-GDPKAIEIELAKHHVLQNDVLAHQST 4376
Query: 5088 IVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNN 5147
+ A+ + + L ++ + L + + QRW + + +++ L+ A+ + GF+
Sbjct: 4377 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4436
Query: 5148 KVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSM 5207
+++ + + + L S L H E ++ L Q+ M
Sbjct: 4437 EIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4496
Query: 5208 LQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCW 5267
L A E + Q+I ++++ +++ K+ +++ L + W
Sbjct: 4497 L---ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4553
Query: 5268 VQETKEYLG---NPTIEIDA---QLEELQILLTEATNHRQNIEKMAE--------EQKEK 5313
+ + ++ L P++ +D Q++E ++ E +HR+ I ++ + QK+
Sbjct: 4554 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4613
Query: 5314 YLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
+ + +L S S V ++ + D K +Q +L +++ K L +
Sbjct: 4614 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4673
Query: 5374 LTKL----KAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK 5429
L K KT + Q K QK LG + + + + L++ L K
Sbjct: 4674 LEIANDPDKIKTQ-LAQHKEFQKSLGAK-----HSVYDTTNRTGRSLKEKTSLADDNLKL 4727
Query: 5430 IGKLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN 5486
L+EL + ++ R +KL +A ++ + L+ ++ W+ + +
Sbjct: 4728 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE---------- 4777
Query: 5487 SASQLREQYILH------QTLLEESKEIDSELEAMTEKLQYLT---------SVYCTEKM 5531
QL E +H L++ K EL T +Q L S + +
Sbjct: 4778 --PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4835
Query: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV-- 5589
Q+ EL E + + + L+ A + ++F + + L L +A+ TL V
Sbjct: 4836 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4895
Query: 5590 -GRLSLKEQLSHRQHLLSEMESLKPKV-QAVQLCQSALRI--PEDVVASLPLCHAALRLQ 5645
+L+ + + + ++E + ++ +A + + L I P+ + + H ++
Sbjct: 4896 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITT---IKHWITIIR 4952
Query: 5646 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI--EDKPVATSNIQEL 5703
+ A Q + +A+ ++ ++ L ++ A + +DK V I+E+
Sbjct: 4953 ARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5012
Query: 5704 QAQISRHEELAQKIKGYQEQIASLNSKCK 5732
+A I+ H+ +++ Q + + K
Sbjct: 5013 KALIAEHQTFMEEMTRKQPDVDKVTKTYK 5041
Score = 270 bits (691), Expect = 4e-71
Identities = 774/4191 (18%), Positives = 1624/4191 (38%), Gaps = 555/4191 (13%)
Query: 4702 LEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVL 4761
L S + H+ + + +E S+KE +K++E + A KL Y L+ L
Sbjct: 660 LPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLT-YAEKLHRLESQYAKL 716
Query: 4762 KRVTIHLEDLAPHLDPLA--YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
+ + E HLD L +A +++ W E + + +E + + + D+
Sbjct: 717 LNTSRNQER---HLDTLHNFVSRATNEL-IWLNEKE--EEEVAYDWSERNTNIARKKDYH 770
Query: 4820 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4879
E+ R LD N++ +QE ++ + + ++ A +
Sbjct: 771 AELMRELDQKEE-------------NIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWS 817
Query: 4880 KFTKAKELISADLEHSLAELSELDGDIQEA---LRTRQATLTEIYSQCQR---YYQVFQA 4933
+ + + ++ + A E D +EA LR + + YS C R +++
Sbjct: 818 WILQLCQCVEQHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYS-CDRSSSIHKLEDL 875
Query: 4934 ANDWLEDAQELLQ-------LAGNG-----LDVESAEENLKSHMEFFSTED--QFHSNLE 4979
+ +E+ +ELLQ L G L +++ LK+ + + D Q +
Sbjct: 876 VQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIY 935
Query: 4980 ELHSLVATLDP------LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL-LQRCTAQW 5032
+ V + +I PTG E + V + + D +++ Q W
Sbjct: 936 KDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW 995
Query: 5033 HDYQKAREEVIE---LMNDTEK-KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI 5088
H+ + V+ L+N+ ++ + S + +KT EH+ ++S + S E
Sbjct: 996 HESHINMKSVVSWHYLINEIDRIRASNVASIKTMLP-------GEHQQVLSNLQSRFEDF 1048
Query: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
LE+ +G+D ++ L + + Q + L A+ +E+ E++V + + ++
Sbjct: 1049 --LEDSQESQVFSGSDITQ--LEKEVNVCKQYYQELLKSAEREEQ--EESV--YNLYISE 1100
Query: 5149 VKKATEMIDQLQDKLPG---SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTL 5205
V+ ++ +D+L + E+ E + + + ELE+ + LG + +
Sbjct: 1101 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1160
Query: 5206 SMLQDGAAPTPGEEPPLMQEITAM---QDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262
AA + P L E+ + ++ +M K V LK+ + E +
Sbjct: 1161 EFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1218
Query: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTIL 5321
+ + E + + + I+ + L+ +E RQ + +E QK K +
Sbjct: 1219 LYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS----- 1272
Query: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
E+ E LD + D++ E Q + QI +DL I LK
Sbjct: 1273 -DEMFKTYKERDLDFDWHKEKADQLVE------RWQNVHVQIDNRLRDLEGIGKSLKYYR 1325
Query: 5382 DN-------VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLT 5434
D + Q +T Q+ + E NSK + QK L ++ + + K
Sbjct: 1326 DTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1384
Query: 5435 ELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW-IEKAKVLAHGTIAWNSASQLRE 5493
E + T++ E + Y M++ K +++ ++ + + LR
Sbjct: 1385 EQYSATVKDYELQTMT----------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1434
Query: 5494 QYILHQTLL---------------EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538
+Y TL+ EE K ++ E + EK + L + + AE
Sbjct: 1435 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1494
Query: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598
+ +Q I + ++ + ++ L+ +Q L + +T E L + +
Sbjct: 1495 AGKPPFSKQKI-----SSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1549
Query: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP---------LCHAALRLQEEAS 5649
+ L ESLK ++Q Q +++ E +VA +C L Q E
Sbjct: 1550 LQESYNLLFSESLK-QLQESQT-SGDVKVEEKIVAERQQEYKEKLQGICD--LLTQTENR 1605
Query: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 5709
+ H Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + + T N +
Sbjct: 1606 LIGH---QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLK-----EN 1657
Query: 5710 HEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
E+L+Q+ K EQ + KC+ L +KA+ + L + E TE +
Sbjct: 1658 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1717
Query: 5769 SAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGTN-SEISSPPACRS------ 5810
S S V + R T V E++G +EG S I
Sbjct: 1718 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1777
Query: 5811 -PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 5867
V T ++NQ YQ + A E++ + + +T ++Q E + + +
Sbjct: 1778 VDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKE 1834
Query: 5868 DLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5926
LQ++ + LK YE AL +K S+ ++E + +E + E
Sbjct: 1835 KLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE 1886
Query: 5927 SQMAEHQALMDEILMLQDEINELQSSLAEELVS-------------------ESCEADPA 5967
++ +A D+I L ++ Q S +E+++S +SC
Sbjct: 1887 QELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1945
Query: 5968 EQLALQSTLTVLAERM--STIRMKAS-GKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL 6024
++ +T + ++ +T R ++ K +L L D +++ Q Y + L
Sbjct: 1946 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY------QHYEDASCGL 1999
Query: 6025 DSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
+ L + +AT LS P +P +++ QL + + + +I + VA+ +L E +LL+
Sbjct: 2000 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAE-VLLD 2058
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 6142
+ + L + G +L ++++++ +Q +T T+S VQ
Sbjct: 2059 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------------ITLTRSLSVQ 2106
Query: 6143 EWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSVASRGEEILIQHSAAE 6195
+ L + W +SSL++Q + L+ +++ L + +A R I + +
Sbjct: 2107 DGLDEM-LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2165
Query: 6196 TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH--QEFSTKQKLLQNVLEQEQEQV 6253
+ + S + M+ + + E+L +E TK +L +N+ E+ Q
Sbjct: 2166 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL--SEKLQT 2223
Query: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY 6313
+ L+ V DVP +D + L+Q +E +S+ K+ L L
Sbjct: 2224 FLETKTQALTEV-----DVPGKDVTE-------LSQYMQESTSEFLEHKKHLEVLHSLLK 2271
Query: 6314 DGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAF 6373
+ +++ LP + L L+K KEM + + + K +
Sbjct: 2272 E-----------------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC- 2313
Query: 6374 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQILNFQN--DLKVLFTSL 6429
E D V+ +L + + +V + + L+ Q LK
Sbjct: 2314 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2373
Query: 6430 ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------ 6483
+N I L L + P A+ I A++ +G L G E+
Sbjct: 2374 VNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNGEGTATNTEEFWANKG 2422
Query: 6484 --PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540
++++ + Y++L +++ + + LN L+ L+ E + + L + +
Sbjct: 2423 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2482
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET--------QFH 6592
Q + E ++ ++++K + L+ ++ + L K+ + Q
Sbjct: 2483 QQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQML 2542
Query: 6593 TELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 6652
TE+ ++ + + R +LE + + +L + L E + +G + + +
Sbjct: 2543 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2602
Query: 6653 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD------LESQLNQLGECWL 6706
L + Q L +P+ Q+ G+ +L S D ++ QL + + W
Sbjct: 2603 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLRGIVKEQLAAVTQKWD 2661
Query: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
S T ++S ++ + T+YQS L L ++L S+ V + +
Sbjct: 2662 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS----SSLAVSTHPDAMNQ 2717
Query: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 6826
L + +E+ + + L L K + L++ELSR Q +L +
Sbjct: 2718 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSR---QLEGILKSFKD 2772
Query: 6827 VQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDEDNIKNSIGYK--AIHE 6877
V++K Q S H ++ +W+ +K+E N + I K +
Sbjct: 2773 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT-----KKEEQNKSHPISAKLDVLES 2827
Query: 6878 YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG 6937
++ +K F + + +++ + + ++++ S+K QL + +W
Sbjct: 2828 LIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2884
Query: 6938 LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997
V E+ L+ LE +Y+ V+ L W + + L++ D A +N++ + L+
Sbjct: 2885 QVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQ 2944
Query: 6998 ------------------DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST---LREL 7036
L+ E + E + +LIQ K + V+ + S L +
Sbjct: 2945 KEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCLENM 3003
Query: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096
Q + + + K L+ +Q H D + S +Y L+ + SL+A++
Sbjct: 3004 TQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY-LTMLQTQQKSLQALK 3058
Query: 7097 VQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
QVD + L DL + E Q+ +++ Q+ ++C L L
Sbjct: 3059 HQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC-----SFLETKL 3113
Query: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
+ + N + E ++ + L + +D A T+Q+Q++ LK
Sbjct: 3114 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQKETIKAFLKKLEALM 3168
Query: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
++D + C +L T D + I+ D +LS+
Sbjct: 3169 ASNDNAN---KTCKMMLATEETSPDLV--------------------GIKRDLEALSKQC 3205
Query: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322
L ++ ++ + E F L+ + +AEE + Q P + TI +++
Sbjct: 3206 NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV-GMETETINQQL 3264
Query: 7323 EELKG-QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL-------NRHWSLISSQTT 7374
K Q + + +N LG L + + Q L N W ++ +
Sbjct: 3265 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3324
Query: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRAHELFQAE 7432
+R ++LQ LL F + E+ + ++V TE+ +A + S ++ + Q + +L Q
Sbjct: 3325 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3384
Query: 7433 MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7492
+ R+ + I +G+++ + D+ + +L+LL ++W+ ++ +A+ R ++
Sbjct: 3385 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3444
Query: 7493 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVFLRQQGSY 7550
Q++ E E L +WL + ++ PI Q ++ Q K E +
Sbjct: 3445 VAQQFHETLEPLNEWLTTIEKRLVN---CEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3501
Query: 7551 ILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASMRLEEQKKKLAFLLKD 7603
V G+ L + + + +Q++L EIQEK S S L++ +D
Sbjct: 3502 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3561
Query: 7604 WEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQ----MRCKELENAVGSWTDDL 7657
+ + + +KL + ++ L EL Q +R + ++ A+ L
Sbjct: 3562 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQAL------L 3615
Query: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
L LLK T + D++ I+ +++E ++ +++++ + + + + L
Sbjct: 3616 NGLELLKQT-----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3670
Query: 7718 NKELCEWLTQMESKV-SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKAS 7776
++ELC WL ++E ++ S +L E + + +E A+ NK L + E ++ A
Sbjct: 3671 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNE-VSSAL 3729
Query: 7777 HES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 7832
E +A E +E + + N+R++ + D I +V+++ ++ QQ D+ + +W+
Sbjct: 3730 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3789
Query: 7833 IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7892
E +L + ++ +L Q+ +I +H + ++ ++ C ++
Sbjct: 3790 TEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC----SE 3844
Query: 7893 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 7952
E S+++ + + + IC ++ ER L++E L +F + Y WL ++ +
Sbjct: 3845 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3904
Query: 7953 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 8012
+ + Y +++ ++ + + E ++ +NK +L E S+++
Sbjct: 3905 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGEGFSIQEKYV 3963
Query: 8013 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8072
+ + +++ V L I Q +F D IL L + +L S +V+
Sbjct: 3964 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS-AEVE 4022
Query: 8073 AKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIEEELDELRRY 8124
KIK+ + + +S++ K+ E + +GE++I +S + + A ++++LD++
Sbjct: 4023 -KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFI 4081
Query: 8125 CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 8184
+ + VE +RE +L D L++ W D + +++ + +
Sbjct: 4082 WENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS-LIVTIKDTQ 4121
Query: 8185 NLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
+ L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4122 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC--------- 4172
Query: 8238 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 8297
G+ DK + I E A+ L + A+++ + Q L
Sbjct: 4173 -GEPDKPIVKKS--------IDELNSAWDSLNKAWKDRIDKLEEAMQAAV-QYQDGLQAV 4222
Query: 8298 RFQIQQTENIIRSKTPTGPELDTSYKGYMKLL---GECSSSIDSVKRLEHKLKEEEESLP 8354
+ + S +P G +L+T + +L E ++RL H+ + + +
Sbjct: 4223 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4282
Query: 8355 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8414
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4283 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4342
Query: 8415 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 8473
L + + + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4343 LSEQK--PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4400
Query: 8474 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 8533
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4401 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4460
Query: 8534 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 8578
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4461 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4513
Query: 8579 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8629
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4514 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4558
Score = 270 bits (691), Expect = 4e-71
Identities = 734/4041 (18%), Positives = 1546/4041 (38%), Gaps = 628/4041 (15%)
Query: 449 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1141 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1198
Query: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
K++ + L +L AE+ +K + K E+V N + I K +
Sbjct: 1199 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE----- 1250
Query: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
+ + +++ + +++A+ + M +T + R+L + ++ ++++ W N
Sbjct: 1251 -VDEKRQVFHALEDELQKAKAISDEMFKTYKE-RDLDFDWHKEKA--DQLVERWQ---NV 1303
Query: 629 VASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ 688
+ L D E + +S +D + L WIQQ + ++ L Q
Sbjct: 1304 HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ 1362
Query: 689 QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT----DCVVTLSAFATEAHKKLSEPLEV 744
Q +L++ +E+KQ ++ DE + ++Y+ D + + + P++
Sbjct: 1363 QKMLVSE------IEMKQ-SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR 1415
Query: 745 SFM--NVKLLIQDLEDIEQR----VPVMDAQYKIITKTAHLITKE--SPQEEGKEMFATM 796
M + L+IQ+ D+ R V +M K + + +E S +EE KE
Sbjct: 1416 RRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA 1475
Query: 797 SKLKEQLTKV-----------KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEII 845
+L++ ++ + K +S S+++ E+L + + + L K + +
Sbjct: 1476 KELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKM 1535
Query: 846 TVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ---- 901
T ER + + L E+ K+ G V++ + ++ ++
Sbjct: 1536 TDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGI 1595
Query: 902 ----TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
T+ + ++ AF + T + KK+ L K + S L +V++ + L
Sbjct: 1596 CDLLTQTENRLIGHQEAFM-IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1654
Query: 958 EEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD 1017
+E G+ + E + ++Q++ A +K C++L ++ EQ ++ L + V
Sbjct: 1655 KENGE-----KLSQEDKALIEQKLNEAKIK-CEQL-NLKAEQSKKELDKVVTTA------ 1701
Query: 1018 LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP--QEGSEKIIKEHRVFFSDK 1075
+K + EK + +EE +T+++ + + SE+ +H+
Sbjct: 1702 -----------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1750
Query: 1076 GPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD 1135
G H I E D V ++ ++ + +T L + K K
Sbjct: 1751 GTHFQEGDGKSAIGE-------EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVK- 1797
Query: 1136 YTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRL 1195
++ IS ++ + + + G+ E+ E L L
Sbjct: 1798 -----AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEK---------EKLQKNMKEL 1843
Query: 1196 KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
KV E + LA+ K +L E+EK +++ + + + + LE L
Sbjct: 1844 KVHYETA-----------LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 1892
Query: 1256 ISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD 1315
+G+ ++ K+ ++ E ++ H+ + I+ V + + +GG D
Sbjct: 1893 EAGADDINGLMTKLKRQKSFSED---VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1949
Query: 1316 RG--HEEL-RKLESTLDGLERSRERQE---RRIQVTLRKWERFETNKETVVRYLFQTGSS 1369
H E+ RKL+ D + ++ + K++ +E ++ L ++
Sbjct: 1950 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2009
Query: 1370 HERFLS---FSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL---- 1422
+ LS ++L +LE+TK + S V E L K+ +E+ L + L
Sbjct: 2010 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL-KKTAEVLLDARGSLLPAKN 2068
Query: 1423 ------------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470
+ +KS+ E+ +KL+ TL + + + D G+ +
Sbjct: 2069 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN--------VE 2120
Query: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530
KE + +S+A+ IS+ + Q+I + SSI + E+ + F + ++ ++
Sbjct: 2121 SSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQ 2180
Query: 1531 AKLTQI-RRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI- 1588
AK+ + R+ E +H + L + L + + ENL + Q+ E + + + +
Sbjct: 2181 AKMKDLSARFSEASHKHKETL--AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2238
Query: 1589 CSSATETYKVLQ-------EHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ 1641
TE + +Q EH + L SL I++ + K + + + +
Sbjct: 2239 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNNLSKKFK 2297
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA------- 1694
+ ED ++ KE T+ + L +Q L K L S W++ K + A
Sbjct: 2298 EMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAEDLGKSL 2354
Query: 1695 -DRVKVEGELQL----IQALQNEVVSQASFYSKLLQLKESLFSVAS-------------- 1735
D K++ + L IQ + N +S + S + +++ +V S
Sbjct: 2355 EDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNT 2414
Query: 1736 -----KDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
+ +K + + + DL ++ +I L + +++ Q+ E + W+
Sbjct: 2415 EEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQK 2474
Query: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED- 1845
K QT + + + ++K AE++ ++Q L+ L +L L D
Sbjct: 2475 MNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL--LEENPDT 2532
Query: 1846 ---------LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGIL--RQL 1894
L + K ++ QL + Q +E + ++L +F A L L ++L
Sbjct: 2533 PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEE---SSNNLTQFQTVEAQLKQWLVEKEL 2589
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQ----NAKALESAAVSLDGILSKAQYHLKIGSSE 1950
+V S++ N + + + LQ E + GILS+ E
Sbjct: 2590 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--------PGE 2641
Query: 1951 QRTSCRATADQLCGEVERIQNLLGTKQSEADAL--AVLKKA-FQDQKEELLKSIEDIEER 2007
+ +QL ++ +L G D + A++K +Q L + D++ +
Sbjct: 2642 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2701
Query: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ--KDVAFAPEVDR 2065
A+ Q+L +++ E+ + ++ + + ++ K+ E+ R
Sbjct: 2702 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2761
Query: 2066 EINRLEVTWDDTKRL----IHENQGQCC-------------GLIDLMREYQNLKSAVSKV 2108
++ + ++ D ++ + Q C +D +E QN +S
Sbjct: 2762 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2821
Query: 2109 LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS 2168
L+ V + IKD +D FSK TA++ M K ++G++L L K
Sbjct: 2822 LD------VLESLIKDHKD----FSKTLTAQSHMYEKT------IAEGENL---LLKTQG 2862
Query: 2169 SDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL-----------SIW----------D 2207
S+ + ++ + + W +++++E ++L+ SL ++W +
Sbjct: 2863 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2922
Query: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK----------EFESEV---KNK 2254
++ D EG N + ++ +D H ELL E + EV +NK
Sbjct: 2923 EIKFCLDPAEG--ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2980
Query: 2255 AL------RLEELHSKVNDLKELTKNL--------ETPPDLQFIEADL------------ 2288
+L E+LHSK L+ +T+ E+ LQ + L
Sbjct: 2981 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3040
Query: 2289 ----------MQKLEHAKEITEVAKGTLKDFTAQST----------QVEKFINDITTWFT 2328
+ L+ K ++AK +D +++ QVE + +T
Sbjct: 3041 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3100
Query: 2329 KVEESL---------MNCAQNETCEALKKVKDIQKE-------------LQSQQSNIS-- 2364
+V+E + QN E + + E LQ Q+ I
Sbjct: 3101 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF 3160
Query: 2365 --------STQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK 2416
++ +N N C+ + E S + G+ + EA+S+ C+K Q + E+
Sbjct: 3161 LKKLEALMASNDNANKTCKMMLATEETS--PDLVGIKRDLEALSKQCNKLLDRAQ-AREE 3217
Query: 2417 HFSESMQEFQEWFLGAK------AAAKESSDRTGDSKVLEAKLHDLQNIL-----DSVSD 2465
+++ +E++ K A+E + G + ++ N+ + +
Sbjct: 3218 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3277
Query: 2466 GQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQALQDCASEL 2524
Q K V GQ L +K ++ + N ++ K+ + LQ+
Sbjct: 3278 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3337
Query: 2525 GSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES-LDK 2583
G F+D L W+ + EE + ++ + + + + K+ L LL R+S ++
Sbjct: 3338 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL---LQRLLDDRKSTVEV 3394
Query: 2584 LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ------VALQEHEALE 2637
+ + G+ ++ A + L L + + K + R+ Q VA Q HE LE
Sbjct: 3395 IKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3454
Query: 2638 EALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ---IQDILLMKGEGEVKLNMAIGK 2694
+ W+ I+ RL E LE++++Q ++D ++ + L+ A+
Sbjct: 3455 PLNE----WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK---HLHQAVSI 3507
Query: 2695 GEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2754
G+ S++E + ++Q++L+ + + +I S L+ + + E + +L
Sbjct: 3508 GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3567
Query: 2755 WMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK---T 2811
W+ V K+ K + D+ L + + R L I ++ ++
Sbjct: 3568 WLNEVHDKL-----------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3616
Query: 2812 EDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELH 2871
E K T +E+ D + K + + + ++ D L+ + LHS EEL
Sbjct: 3617 GLELLKQTTGDEVLI-IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3675
Query: 2872 RWSD-------------MSGDSSA--------TQKKLSKIKELIDS-REIGASRLSRVES 2909
W D + G+ ++ +K+ K L+DS E+ ++ L V
Sbjct: 3676 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3735
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA-LSEQE---F 2965
A E + A E + ++ + ++ ++Q + ++++ ++E E
Sbjct: 3736 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3795
Query: 2966 SGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR 3022
S +LEQ +Q SA L KT+ + +L K+ +++V+ HK I+ A +E
Sbjct: 3796 SLGDIRLEQ--DQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHK---IMTAC--SEEE 3846
Query: 3023 TEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLC-LQASKGCQ-NKEQILQQRFRKAF 3080
+ +K +L++ ++K Y+ +C + + + Q + Q L +F + +
Sbjct: 3847 KQSMKKKLDK-----------------VLKNYDTICQINSERYLQLERAQSLVNQFWETY 3889
Query: 3081 RDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF--LSE--SENGQHKLNMMLSKGE 3136
+ WL T + +P E T Q+ +E L E +E+ H M + +
Sbjct: 3890 EELWPWLTE---TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3946
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
LL L+ + IQ K AA + ++ ++ AL+ Q F + I + L
Sbjct: 3947 LLE--LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4004
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL------WEG 3250
+ + + + + ++ + + + ++V ++ +P LK++ +++ +
Sbjct: 4005 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4064
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKEKVSRL-------DRIVAEHNQFSLGIKELQDWM 3303
++K+ + ++ Q+ + + L +E+ ++L ++ +H + IK+ QD++
Sbjct: 4065 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4124
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
D P D SV+ + E + + ++ +++ G ++
Sbjct: 4125 RDLE-------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDK 4177
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
P +++ + + W SL A +LE A+ YQDG++ W+D L
Sbjct: 4178 PIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS 4237
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIE-------VKGAGMTEHYVTQLELQDL 3476
+L + + K E +E + K ++ + Q L +L
Sbjct: 4238 PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMEL 4297
Query: 3477 QERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHE 3536
+ + +++ER K E + ++Q L WL + L + + GD E
Sbjct: 4298 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4357
Query: 3537 TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALESLRQDWQAYQHRL 3593
L LQ Q+ + +V D+I S + LE L Q WQ +
Sbjct: 4358 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4417
Query: 3594 SETRTQFNNVVNKLRLMEQKFQQVDEWL-----------------KTAEEK-KWHEEVTA 3635
+ + Q + + + + + + + +WL +TA+E+ H EV A
Sbjct: 4418 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4477
Query: 3636 YRDEVEE----VGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3689
+ EE + + Q++L + + L +++++ ++ E+ LEE +
Sbjct: 4478 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4537
Query: 3690 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV-DTVMMGKKLKTLEVLLKDMEKGHSL 3748
E +SL + +W + NVA++ + DTV+ ++ +V ++
Sbjct: 4538 NLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF--QIDEHKVFANEVNSHREQ 4594
Query: 3749 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3808
+ + G + ++ + ++ + + +++ + + +L+ AK+F +
Sbjct: 4595 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4654
Query: 3809 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3868
L +W+ E ++ L E + + K QL+++K Q+++ + + G +L
Sbjct: 4655 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714
Query: 3869 LELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3928
E +L D D L+ D D L+ L+ K DT+ G+ + Q
Sbjct: 4715 KE---KTSLAD--DNLKLD-------------------DMLSELRDKWDTICGKSVER-Q 4749
Query: 3929 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 3988
KL++ + Q T D+ A+ R+ L + H D + A Q +L
Sbjct: 4750 NKLEEALLFSGQFT-DALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKEL 4807
Query: 3989 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLD--------LLCSMCDLSNASVKTTAKDI 4040
K+ +AL+ AR ++ + M +LS A I
Sbjct: 4808 G-------------KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4854
Query: 4041 QQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL--ELNIAQ 4098
+ + +E L QA EE + L +L +A+Q L R H L + + +
Sbjct: 4855 SK-QTRLEAALRQA-------EEFHSVVHALLEWLAEAEQTL----RFHGVLPDDEDALR 4902
Query: 4099 NMVSQVKDFVKKLQSKQASVN 4119
++ Q K+F+KKL+ K+A +N
Sbjct: 4903 TLIDQHKEFMKKLEEKRAELN 4923
Score = 264 bits (674), Expect = 3e-69
Identities = 856/4706 (18%), Positives = 1829/4706 (38%), Gaps = 694/4706 (14%)
Query: 2615 LLRMTKEKLRSCQVA--LQEHEALEEALQSMWFWVKAIQ---DR------LACAESTLGS 2663
L+++ K L+S + L E E + +Q + WV +Q DR L ES L +
Sbjct: 610 LMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN 669
Query: 2664 KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723
+ + + + + L E+++ + + +L L+ +A
Sbjct: 670 HKNVHRAIEEFESSLKEAKISEIQMTAPL--------------KLTYAEKLHRLESQYAK 715
Query: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWM-ESVDQKIEHPLQPQ-PGLKEKFVLLD 2781
++++S + + L+++ +++V R W+ E ++++ + + + K
Sbjct: 716 LLNTSRNQERHLDTL----HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 771
Query: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841
L L + E++ +++ + + L E + + ++TQ++ I+ + +
Sbjct: 772 ELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQTQWSWILQLCQ----C 825
Query: 2842 VEEIVKDHLMYLDAVH---EFTDWLHSAKEELHRWSDMSGDSSA------TQKKLSKIKE 2892
VE+ +K++ Y + + E TD+L + K+ + R SS Q+ + + +E
Sbjct: 826 VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 885
Query: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC-L 2951
L+ + A+ + + +++ +N S C L + D++Q E ++++ C L
Sbjct: 886 LLQYKSTIANLMGKAKTIIQLKPRN---SDCPLKTSIPIKAICDYRQIEITIYKDDECVL 942
Query: 2952 ENLVSQMALSEQEFSGQVAQL-----------EQALEQFSALLKTWAQQLTLLEGKNTDE 3000
N + +G A + ++A++ + + + + LTL + +
Sbjct: 943 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 1002
Query: 3001 EIVECWHKGQEILDALQKAEPRT-------------EDLKSQLNELCRFSRDLSTYSGK- 3046
+ V WH +D ++ + + +L+S+ + S++ +SG
Sbjct: 1003 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1062
Query: 3047 VSGLIKEYNCLCLQ------ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDI 3100
++ L KE N +C Q S + +E+ + + R+ + L N + +
Sbjct: 1063 ITQLEKEVN-VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1121
Query: 3101 PQNISEVSTSLQKIQE---FLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTA 3156
P ++ S+ +I E E E + L + +K E S +++++
Sbjct: 1122 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1181
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT--EKMVHESSNRLYDLP 3214
++ +S L+ + + +K+ + + ++ + +K E+ V N + +L
Sbjct: 1182 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1241
Query: 3215 AKRRE-QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN 3273
+ ++ + ++ + H E +L + K + +++ K+++ R
Sbjct: 1242 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF------KTYKERDLDFDWH------ 1289
Query: 3274 LTKEKVSRL-DRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3332
KEK +L +R H Q +++L+ + D+Y HP D
Sbjct: 1290 --KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY-HPLDDW------------ 1334
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3392
++Q + Q K +Q PE T+ QL K +L + I K
Sbjct: 1335 ---IQQVETTQRK---------IQENQPENSKTLATQLNQQK-----MLVSEIEMKQSKM 1377
Query: 3393 GALSKWTS-YQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS--- 3448
K+ Y V+ + + A ++ ++ + R M A L+ +E +
Sbjct: 1378 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR---RMQSSADLIIQEFMDLRT 1434
Query: 3449 -YSSL--LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505
Y++L L T +K AG + L+ L+E ++++E KE V K+++L +
Sbjct: 1435 RYTALVTLMTQYIKFAGDS--------LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1486
Query: 3506 RDLKAFEV---------------------WLGQEQEKLDQYSVLEGDAHTHETTLRDLQE 3544
+ LK E L + + + + GD T E ++
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1546
Query: 3545 LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN-- 3602
++ L + L ++ SG + E++ + +Q+++ + + TQ N
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1606
Query: 3603 -------VVNKLRLMEQKFQQVDEWLKT---------AEEKKWHEEVTAYRDEVEEVGAR 3646
++ + +K+Q E L+ AE K E ++ E++
Sbjct: 1607 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL--KENGEKLSQE 1664
Query: 3647 AQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE-----IQSLEESESSLSS 3701
+ ++++ +++ C+ L + L + EE ++ LEES++ + +
Sbjct: 1665 DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIEN 1724
Query: 3702 YSDWYGSTHKNFKNVATKIDKV----------------------------DTVMMGKKLK 3733
DW + K+ + TK +V +T + G+
Sbjct: 1725 LLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGT 1784
Query: 3734 TLEVLLKDMEKGHS--------------LLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
T E L + +K + +SA+ E+ +YL E E+L+K +M
Sbjct: 1785 TQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----NM 1840
Query: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
++LK T E EK + L ++ L ++ A+Y E H ++ + EL +A
Sbjct: 1841 KELKVHYETALAES---EKKMKLTHSLQEE---LEKFDADYTEFEHWLQQSEQELENLEA 1894
Query: 3840 ----------QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQ 3889
+L + KS + V+SH+ ++ + G +LE + + +D
Sbjct: 1895 GADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD------GGKV 1948
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
D + + + ++ DR +L K + L D + + H + A
Sbjct: 1949 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK------YQHYE------DAS 1996
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4009
C + Q+ E KH+S + +Q LE + + + Q
Sbjct: 1997 CGLLAGL-QACEATASKHLSEPIAVDP-----KNLQRQLE---ETKALQGQISSQQVAVE 2047
Query: 4010 ALQEQARTYLDLLCSMCDLSNASVKTT----------AKDIQQTEQTIEQKLVQAQNLTQ 4059
L++ A LD S+ N KT +K + + + ++ L ++ ++
Sbjct: 2048 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2107
Query: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119
G +E+ + L++ Q L Q+++S+ + + +Q+S+N
Sbjct: 2108 GLDEMLDWMGNVESSLKEQGQV---------PLNSTALQDIISKNIMLEQDIAGRQSSIN 2158
Query: 4120 TIIEKVNKLTKKEE----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
+ EKV K + + S ++ L+ ++ + + + EE + + +
Sbjct: 2159 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2218
Query: 4176 NVVEVFLEKFT---TEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232
++ FLE T TE D + E + E+ + E K +E L +++
Sbjct: 2219 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL----EHKKHLEVLHSLLKEIS 2274
Query: 4233 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4292
H DK LV E+T++L +++ ++ED IK K + + E+L+ Q + L W +E
Sbjct: 2275 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2334
Query: 4293 -------QPNI-AEAL------------KQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
QP+ AE L K S Q + +++C+ + A K+
Sbjct: 2335 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2394
Query: 4333 L--IKDADRVM-------------ADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4377
+ +K V+ A+ GL I+K ++D L L+ + L
Sbjct: 2395 IAAVKSGGAVLNGEGTATNTEEFWANKGLTS---IKKDMTDISHGYEDLGLLLKDKIAEL 2451
Query: 4378 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD---VSKQVKTCKSAQASLKT 4434
N LS K Q A Q Q K + P D V QV+ KS +A LK
Sbjct: 2452 NTKLS-KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2510
Query: 4435 YQNEVTGLWAQGRELMKEVTE-QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493
N+V L + EL++E + E L E+ S + + Q R Q+LE++ +
Sbjct: 2511 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2570
Query: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ----SPEYENLLL 4549
F+ + WL + +++ L + + L+TQ + Q +L++ P+YE L
Sbjct: 2571 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2630
Query: 4550 T----LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4605
L R G+ PSL + + E+L A+ ++++ + D+ + +AI+ +Y
Sbjct: 2631 AGQGILSRPGED--PSLRGI----VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQY 2684
Query: 4606 ASLIELTTQSLSELEAQFLRMSKVPT-----DLAVEEALSLQDGCRAILDEVAGLGEAVD 4660
SL+ + LS+L+ + V T + +E A ++ + ++ +
Sbjct: 2685 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2744
Query: 4661 ELNQ-KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
+L+ KE + Q + +L + ++++ E V L+ ++ + ++M +
Sbjct: 2745 DLSALVKEEYLKAELSRQLEGIL---KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF 2801
Query: 4720 ERQLKSVKEEQSK---VNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD 4776
+ L + KEEQ+K ++ + E +K + + +L + ++ E+L L
Sbjct: 2802 QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL--LK 2859
Query: 4777 PLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID----FQTEMSRSLDWLRRV 4832
EKA Q+Q +K + V E E+++ +S++ ++ ++ W+ +
Sbjct: 2860 TQGSEKAALQLQ--LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2917
Query: 4833 KAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA---KELIS 4889
+ L + L+ + + I K++ Q+E+ ++ L++ + KE+++
Sbjct: 2918 QNNLE-EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2976
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 4949
D SL + ++ + E L +++ L + + + + +V + + L+ A+E L +
Sbjct: 2977 -DENKSLIQKVDM---VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH- 3031
Query: 4950 NGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL--DPLIKPT---GKEDLEQKV 5004
D ++ ++ T+ + L+ L L D +++ + G D+ +V
Sbjct: 3032 ---DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQV 3088
Query: 5005 ASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS 5064
++ +S+ + L+ +Q E+ + + +L + + +
Sbjct: 3089 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA- 3147
Query: 5065 HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ-------LEKTGNDASKATLSRSMTTV 5117
E L + K + E ++A + A++ E+T D + R + +
Sbjct: 3148 ----ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL--VGIKRDLEAL 3201
Query: 5118 WQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELL 5177
++ +L AQ +E+ +E + F +K+K+ + ++ + ++ ++ E
Sbjct: 3202 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGMETE 3258
Query: 5178 TLLEYHDTF-VLELEQQQSALGMLRQQTLSMLQDG---AAPTPGEEPPLMQEITAMQDRC 5233
T+ + + F V + E+ + G +QQ ++ L G +A L ++ + R
Sbjct: 3259 TINQQLNMFKVFQKEEIEPLQG--KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3316
Query: 5234 LNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIE---IDAQLE 5287
+ +KV +++ L + + S+ W+ +T+E + N P+ E + AQ++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3376
Query: 5288 ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVA-LDLK---IRDQIQ 5343
E Q LL + R++ ++ + + EK T P++ L +++ LD + + ++ +
Sbjct: 3377 E-QKLLQRLLDDRKSTVEVIKREGEKI--ATTAEPADKVKILKQLSLLDSRWEALLNKAE 3433
Query: 5344 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKL------KAKTDNVVQAKTDQKVLGEE 5397
+ +++E +Q+ ++ L + LTTI +L + + + K L ++
Sbjct: 3434 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3493
Query: 5398 LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ-AENRLSKLNQAAS 5456
+ N L + + Q + + K + + +++ I++ + +R L QA
Sbjct: 3494 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC 3553
Query: 5457 HLEEYNEMLELILKW-------IEKAKVLAHGTIA-WNSASQLREQYILHQTLLEESKEI 5508
+ + + E ++ W + K V + T W S+LR +L + +L + +
Sbjct: 3554 NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNV 3610
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEA 5568
D L E L+ T +V + + E ++ K + D AK +++
Sbjct: 3611 DQALLNGLELLKQTT--------GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3662
Query: 5569 ELKKLQAALEQAQATLTSPEVGRLSLKEQL----------SHRQHLLSEMESLKPKVQAV 5618
++L + E+ L EV LS + Q+ + L E ++ K + ++
Sbjct: 3663 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3722
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM-- 5676
SAL A L E + T Q+ + AA+++ +Q++Q
Sbjct: 3723 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADA 3782
Query: 5677 ---------KHLQQLIEGAHREIEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQIAS 5726
K L L G R +D+ A +Q+ +I RH+++ + +I +
Sbjct: 3783 ELSWITETEKKLMSL--GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3840
Query: 5727 LNSKCKMLTMKAK--------------HATMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 5772
S+ + +MK K ++ L + + L + EL P +
Sbjct: 3841 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3900
Query: 5773 SVVMMTAGRC------------HTLL-------SPVTEESGEEGTNSEISSPP---ACRS 5810
S++ H L P ++ + G SP + +
Sbjct: 3901 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE 3960
Query: 5811 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLE-----PSATAK 5865
A+T S ++ +A++ + + + + H E E +E PS +A+
Sbjct: 3961 KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE 4020
Query: 5866 LGDLQRSWETLKNVI--SEKQRTLYEALERQ-----------------QKYQDSL----- 5901
+ ++ KNV EK + LYE L+++ + QD L
Sbjct: 4021 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4080
Query: 5902 --QSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
++I T +E E KL + E E +H +L+ I QD I +L
Sbjct: 4081 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIKDTQDFIRDL---------- 4127
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN--DQLEEQRQEQALQRY 6017
E DP S + E TIR + G ++ L+ +N +L E
Sbjct: 4128 EDPGIDP-------SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4180
Query: 6018 RCEADELDS-WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE----IEQKVVALSEL 6072
+ DEL+S W KA D + +E M Q D + + K+ ++S +
Sbjct: 4181 KKSIDELNSAWDSLNKAWKD-RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4239
Query: 6073 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6132
E + K + E+L +E++R H +L ++ +E ++
Sbjct: 4240 GTDLETV--------KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT-- 4289
Query: 6133 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 6192
VQ+ L + + W + + +Q +LE L + G+ QH+
Sbjct: 4290 --------VQDPLMELKLIWDSLEERIINRQHKLEGAL----------LALGQ---FQHA 4328
Query: 6193 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQN--VLEQEQ 6250
E +LS++ + G+ + E ++ K +LQN + Q
Sbjct: 4329 LDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL------------AKHHVLQNDVLAHQST 4376
Query: 6251 EQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIH 6307
+ + N L+ ++ S + + L+ LNQ ++ V ++ K+Q ++
Sbjct: 4377 VEAVNKAGNDLIE-------SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4429
Query: 6308 LEQKLYDGVSATSTWLDDVEERLFVATAL--LPEETETCL-FNQEILAK-DIKEMSEE-- 6361
+ + + WL D E L + L LPE + L + E+ A + KE + +
Sbjct: 4430 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4489
Query: 6362 MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6421
M K + + ++ P++ + I+ + L + +++ +N+R +++E L + F N
Sbjct: 4490 MQKGQQMLARC-PKSAETN--IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4546
Query: 6422 LKVLFTSLADNKYIILQKLANVFEQP------VAEQIEAIQQAEDGLKEFDAGIIELKRR 6475
L+ L ++ NV +P V QI+ + + + IIEL +
Sbjct: 4547 LQDFINWLTQ-----AEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4601
Query: 6476 GDKLQVEQPSMQE------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6529
G L+ L +Q +++++ + R L+ Q+ A L +
Sbjct: 4602 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4661
Query: 6530 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ--- 6586
LE EK + I + ++I+ L +HKE+ + L + + +T R S +
Sbjct: 4662 WLEE-SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4720
Query: 6587 -----KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6641
K +EL + + ++ +R +LE L + Q L L VE +
Sbjct: 4721 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4780
Query: 6642 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQL 6698
V + D +++ I ++ + L + + Q L R LI S D ++ Q+
Sbjct: 4781 AEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELIEGSRDDSSWVKVQM 4839
Query: 6699 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 6758
+L W + + RLE L+ + S L+ WL A+ L F +P
Sbjct: 4840 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRF----HGVLP 4895
Query: 6759 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT-ATLRSELSRIDSQW 6817
+ + +R ++ EF K+++ + + + + G+ +L + D+ T++ ++ I +++
Sbjct: 4896 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARF 4955
Query: 6818 TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-QKDEDNIKNSIGYKAIH 6876
++L Q++L + + + +++W+ E + KD++ I I + +
Sbjct: 4956 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI--EEVK 5013
Query: 6877 EYLQKYKGFKIDINCKQLTVDFVNQS 6902
+ +++ F ++ KQ VD V ++
Sbjct: 5014 ALIAEHQTFMEEMTRKQPDVDKVTKT 5039
Score = 245 bits (626), Expect = 1e-63
Identities = 593/3347 (17%), Positives = 1290/3347 (38%), Gaps = 356/3347 (10%)
Query: 544 EQLLQNYVSF-IENSKFFEQYEVTYQILKQTAEMYVKADG---SVEEAENVMKFMNETTA 599
E L Q Y ++ K Q++ I Q+A++ ++ G S EE E + K M E
Sbjct: 1787 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1845
Query: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH 659
+ E + + +++ + WL+ +E+ L E D +
Sbjct: 1846 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1905
Query: 660 WIQQHTAMND-------------AGNFLIETCDEMVSRD------------LKQQLLLLN 694
+Q + D +GN ++E RD ++++L
Sbjct: 1906 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1965
Query: 695 GRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNV 749
R+R L+ + D+ + + L A A K LSEP+ V N+
Sbjct: 1966 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2025
Query: 750 KLLIQDLEDIEQRVPVMDAQYKIITKTAHLI---------------------------TK 782
+ +++ + ++ ++ + + KTA ++
Sbjct: 2026 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2085
Query: 783 ESPQEEGKEMFATMSK-------LKEQLTKVKECYSPLLYESQQLLIPLEE--------- 826
+S E +++ T+++ L E L + S L + Q +PL
Sbjct: 2086 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ---VPLNSTALQDIISK 2142
Query: 827 ---LEKQMTSFYDSLGKINEII-------------TVLEREAQSSALFKQ---KHQELLA 867
LE+ + S+ +NE + ++ + SA F + KH+E LA
Sbjct: 2143 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2202
Query: 868 CQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWK 926
E K + L E S+ +Q F+ T + L D + + ++ Q + + K
Sbjct: 2203 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP--GKDVTELSQYMQESTSEFLEHK 2260
Query: 927 KHVETNSRLMKKF------EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQ- 979
KH+E L+K+ + LEK ++++ E + +E T QLD
Sbjct: 2261 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2320
Query: 980 RVLNAFLKA-CDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRF 1038
+VL LK+ E T +P + E + K + K LQ + ++
Sbjct: 2321 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2380
Query: 1039 LASVEECRTELDRETKLMPQEGS----EKIIKEHRVFFSDKGPHHLCEKRLQL---IEEL 1091
L ++ T + + G+ E F+++KG + + + E+L
Sbjct: 2381 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2440
Query: 1092 CVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1151
+ L + +T + +E +A+ +K+ + KW+ + + + T
Sbjct: 2441 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD--TEAVKTQV 2498
Query: 1152 TQLKGIKGEAIDTANH-GEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQ 1210
Q K + E N E+K + E+ E W ++LTE+ S+ + Q
Sbjct: 2499 EQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW----KQMLTEIDSKWQELNQ 2554
Query: 1211 --GDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEK 1268
D KL S L T VE L + + KE++ + L L + Q ++
Sbjct: 2555 LTIDRQQKLEESSNNL-TQFQTVEAQLKQW---LVEKELMVSVLGPLSIDPNMLNTQRQQ 2610
Query: 1269 ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD-----RG--HEEL 1321
+ Q+LL A ++ +Q+ A QG P RG E+L
Sbjct: 2611 V----------QILLQE-------FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2653
Query: 1322 RKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL-- 1379
+ D L + I + K T ++++R L S + LS SSL
Sbjct: 2654 AAVTQKWDSLTGQLSDRCDWIDQAIVK----STQYQSLLRSLSDKLSDLDNKLS-SSLAV 2708
Query: 1380 ----ESLSSELEQTKEFSKRTESIAVQ---AENLVKEASEIPLGPQNKQLLQQQAKSIKE 1432
++++ +LE ++ + + Q A+ L ++ S + K L +Q + I +
Sbjct: 2709 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2768
Query: 1433 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1492
K +E E ++ ++ F W+ K++E N S+ +D+ S
Sbjct: 2769 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2828
Query: 1493 IKVTIQEIESKLSSIVGLEE----EAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQ 1548
IK ++ L++ + E E ++ E A ++ +L I+ + + +
Sbjct: 2829 IK-DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVK 2887
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATE------TYKVLQEH 1602
E + L + K++E + + + + ++ L IK C E K LQ+
Sbjct: 2888 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKLKSLQKE 2946
Query: 1603 MDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLA 1662
MD + L + TA S + ++++ E +L Q+ + + + ++ LEN+
Sbjct: 2947 MDQHFGMVELLNN-TANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQ 3005
Query: 1663 HWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK 1722
++ ++ +K S ++ + +++ + L QA N+ ++ K
Sbjct: 3006 KFKEFQE------------VSKESKRQLQCAKEQLDIHDSLG-SQAYSNKYLTMLQTQQK 3052
Query: 1723 LLQ------------LKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSV 1770
LQ ++ + + + L +E + + L Q ++++ +FL++
Sbjct: 3053 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3112
Query: 1771 VAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSL 1830
+ F + F EL + + + + A T K + E+ K L+ L
Sbjct: 3113 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVG----RDAETLQK----QKETIKAFLKKL 3164
Query: 1831 QGHLAKLGSLGRAEDLHL--------LQGKAEDCFQLFEEASQVVERRQL-------ALS 1875
+ +A + + + L L G D L ++ +++++R Q +
Sbjct: 3165 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3224
Query: 1876 HLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDG 1935
L EF S +L++ + E+ + E++ I + LN K ++
Sbjct: 3225 RLEEFYSKLKEFSILLQKAEEHEESQGPVGM-ETETINQQLNMFKVFQKE------EIEP 3277
Query: 1936 ILSKAQYHLKIGSSEQRTSCRATADQ-LCGEVERIQNLLGT-KQSEADALAVLKKA---- 1989
+ K Q +G +++ ++T+ Q L +++ + T + A A L++A
Sbjct: 3278 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3337
Query: 1990 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2047
FQD E LL + D EE ++ + ++ +++ L+ L+ + + +K
Sbjct: 3338 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3397
Query: 2048 KAKQIA-QKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVS 2106
+ ++IA + A ++ ++++ L+ W+ Q G+ + +++ ++
Sbjct: 3398 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3457
Query: 2107 KVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKK 2165
+ L +V I Q L+ ++H+ ++ + K L S G+ L K
Sbjct: 3458 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-----K 3512
Query: 2166 IHSS--DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE--GWSN 2221
+ SS D +V++ ++ + ++++ EK + L+ +L + + DE+E W N
Sbjct: 3513 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLN 3570
Query: 2222 NCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLE----T 2277
++ + +S L + E L + +SE+ + L+ + L K N + L LE T
Sbjct: 3571 ----EVHDKLSKLSVQDYSTEGLWKQQSEL--RVLQEDILLRKQNVDQALLNGLELLKQT 3624
Query: 2278 PPDLQFIEADLMQKL-----EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2332
D I D ++ + + K T+VAK TL+ + ++ ++ TW KVE
Sbjct: 3625 TGDEVLIIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTHEELCTWLDKVEV 3683
Query: 2333 SLMN-----CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGR 2387
L++ E +A + K+++KE ++ ++ + S E ++L E L +
Sbjct: 3684 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3743
Query: 2388 AMTGLIKKHEAVSQLCSKTQASLQESL--EKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
+ +++ VS ++ + ++ + F ++ W + D +
Sbjct: 3744 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3803
Query: 2446 SKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQA 2505
A+L + + + +D + + G + S++ S+++++ K + +
Sbjct: 3804 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3863
Query: 2506 FLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2565
+ + L+ S + F + + +L W+ E + + + ++ E H
Sbjct: 3864 ICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEH 3923
Query: 2566 KVEMFLGELLAA-RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLR 2624
+ L EL+A + +DK+++ G L E G EG + + L KE ++
Sbjct: 3924 RQ---LRELIAEHKPHIDKMNKTGPQLLELSPG---EGFSIQEKYVAADTLYSQIKEDVK 3977
Query: 2625 SCQVALQE--------HEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
VAL E H+ +++ L+S+ + I +RL S + +++++S+ ++
Sbjct: 3978 KRAVALDEAISQSTQFHDKIDQILESL----ERIVERLRQPPSISAEVEKIKEQISENKN 4033
Query: 2677 ILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ----RVIQTQLETLKEVWADIMSSSVHAQ 2732
+ + + + +GE+ + S + + +Q +L+ + +W +I + +
Sbjct: 4034 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093
Query: 2733 STLESVISQ----WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
+ L V+ W D++ ++ + + + + P +++ + ++I
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQ----EAAETIRE 4149
Query: 2789 EAEDHTRALHRLIAKSRELYEK--TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIV 2846
E + L +I EL D+ + +EL + ++ + K+++ K+EE +
Sbjct: 4150 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4209
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELID---SREIGASR 2903
+ + Y D + DW+ A +L S + D ++++ ++K+ ++I R
Sbjct: 4210 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4269
Query: 2904 LSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2963
L+ L +K+ T S + + L+ W E+ + Q LE + +
Sbjct: 4270 LNHQAELL--LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL----- 4322
Query: 2964 EFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3023
Q + AL++ A L L+ + D + +E +L A T
Sbjct: 4323 ------GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4376
Query: 3024 -EDLKSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRK 3078
E + N+L S + S K+ L + + + + + Q + L+Q F
Sbjct: 4377 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4436
Query: 3079 AFRDFQQWLVNAK---ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3135
D QQWL + + + + +P+ E L E + E + ++ KG
Sbjct: 4437 EIEDLQQWLTDTERHLLASKPLGGLPETAKE---QLNVHMEVCAAFEAKEETYKSLMQKG 4493
Query: 3136 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3195
+ + K I + KE W++ + L+++++ LE +F S + +W
Sbjct: 4494 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4553
Query: 3196 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL--WEGQAA 3253
L++ E+ ++ +S L + + + E++ + Q+ L + L + +
Sbjct: 4554 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4613
Query: 3254 SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY 3313
++ + + S++ + E+ LD QF +L +W+ ++ LDS
Sbjct: 4614 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4673
Query: 3314 CHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS-PEGIPTIQQQLQS 3372
+D + ++ + + K G S+ + TS + + L
Sbjct: 4674 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4733
Query: 3373 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3432
++D W ++ + +++LE AL + D ++ W+ +E L E + H ++
Sbjct: 4734 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4793
Query: 3433 TTMLGKAKLLNEEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQER 3486
++ K +E+ +S ++ ++ ++G+ +V ++++Q+L R+ +
Sbjct: 4794 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV-KVQMQELSTRWETVCAL 4852
Query: 3487 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3546
+ T+ E +R +E+ + A WL + ++ L + VL D T + +E
Sbjct: 4853 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4912
Query: 3547 VHCAEGQALLNSVLHTREDVI----PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
E +A LN + V+ P I + + +R ++ + + + +
Sbjct: 4913 KKLEEKRAELNKATTMGDTVLAICHPDSITTIK-HWITIIRARFEEVLAWAKQHQQRLAS 4971
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQE 3649
+ L ++ + + WL+ AE ++ E+EEV A E
Sbjct: 4972 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5018
Score = 239 bits (611), Expect = 7e-62
Identities = 867/4747 (18%), Positives = 1760/4747 (37%), Gaps = 818/4747 (17%)
Query: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2242
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 620 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 675
Query: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2299
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 676 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 721
Query: 2300 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2355
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 722 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 776
Query: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 777 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 827
Query: 2416 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2463
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 828 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 886
Query: 2464 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2502
+S + + + +T+ + +I ++ AN
Sbjct: 887 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 946
Query: 2503 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2542
+A K C ++ E Q++ L LW HE
Sbjct: 947 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1005
Query: 2543 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2592
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 1006 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1059
Query: 2593 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1060 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1112
Query: 2652 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2702
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1113 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1171
Query: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2762
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1172 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1226
Query: 2763 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2821
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1227 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1282
Query: 2822 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1283 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1342
Query: 2871 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2929
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1343 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1400
Query: 2930 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2989
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1401 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1446
Query: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1447 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1487
Query: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1488 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1541
Query: 3110 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3156
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1542 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1601
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3210
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1602 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1661
Query: 3211 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3258
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1662 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1716
Query: 3259 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3308
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1717 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1776
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3363
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1777 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1833
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1834 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1893
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3465
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1894 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1953
Query: 3466 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3518
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1954 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2013
Query: 3519 ------------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALL----NSVLHT 3562
Q +L++ L+G + + + L++ + + L N + T
Sbjct: 2014 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2073
Query: 3563 REDVI------PSGIPQAEDRALESLRQ------------DWQA-------YQHRLSETR 3597
+D++ + + ++ +L + DW Q ++
Sbjct: 2074 LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNS 2133
Query: 3598 TQFNNVVNKLRLMEQ-------KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEI 3650
T ++++K ++EQ ++E +K E ++ + +++++ AR E
Sbjct: 2134 TALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE- 2192
Query: 3651 LDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH 3710
SH + + +L ++ +E + L E++Q+ E+++ + D G
Sbjct: 2193 --ASHKHKETLAKMEELKTK--------VELFENLSEKLQTFLETKTQALTEVDVPG--- 2239
Query: 3711 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770
K+ ++ + + + + K K LEVL HSLLK G + K L +
Sbjct: 2240 KDVTELSQYMQESTSEFLEHK-KHLEVL-------HSLLKEISSHGLPSDKALVLEKTNN 2291
Query: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
L K + KE+ T++++ + F K+L WI E + + + +P
Sbjct: 2292 LSK-------KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQP 2343
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK-IDQLQSDYQ 3889
+ L K LQ+ P ++ V G +L L+ VT K I ++S
Sbjct: 2344 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2403
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
L G A E L +++ K T I + L LK +
Sbjct: 2404 VLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI-------------- 2448
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL-----SAVQPDLEPSPQPPLSRAEAIKQ 4004
L +L K Q+ WL +A + P+P + ++Q
Sbjct: 2449 --------AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2500
Query: 4005 VKHFRA-LQEQARTYLDLLCSMCDLSNASVKT-TAKDIQQTEQTIEQKLVQAQNLTQGWE 4062
K F A L++ +L + +L + T A +Q I+ K W+
Sbjct: 2501 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK----------WQ 2550
Query: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELE---------------LNIAQNMVSQVKDF 4107
E+ L + L+++ L + ++L+ L+I NM++ +
Sbjct: 2551 ELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2610
Query: 4108 VKKLQSKQASVNTIIEKVNK-----LTKKEESPE-----HKEINHLNDQWLDLCRQSNNL 4157
V+ L + A+ E++ L++ E P +++ + +W L Q ++
Sbjct: 2611 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2670
Query: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER 4217
C ++ + ++ Y + + +K + + L+ S A ST H +A+ + Q+
Sbjct: 2671 CDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVST--HPDAMNQQLETAQKM 2725
Query: 4218 KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK------RKIQVSVTN 4271
K I+ K Q K+ + L D LVKE+ E QLE ++K +K + V +
Sbjct: 2726 KQEIQQEKKQ-IKVAQALCEDLSALVKEEYLKAELS-RQLEGILKSFKDVEQKAENHVQH 2783
Query: 4272 LEELNVVQSRFQEL----MEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327
L+ +FQ++ W + ++ ++ S D+ ++L+ DH L A+
Sbjct: 2784 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS 2843
Query: 4328 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR----RKYLNKALSE 4383
+ + I + + ++ +E+ +Q L+ +++ + + V +R ++ L KAL
Sbjct: 2844 HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY 2903
Query: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443
K Q + ++ + Q + +I F CL P + + KS Q + + V L
Sbjct: 2904 KEQ-VETLWPWIDKCQNNLEEIKF----CLDPAEGENSIAKLKSLQKEMDQHFGMVELLN 2958
Query: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
L+ V E +K V + + L D V ++ + LE K F+E ++
Sbjct: 2959 NTANSLL-SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3017
Query: 4504 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563
L+ A E ++H L S Y N LT+ +T Q
Sbjct: 3018 KRQLQCA-----------KEQLDIHDSLG--------SQAYSNKYLTMLQTQQ------- 3051
Query: 4564 EVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEA-----ILAR-----KEYASLIELTT 4613
+ L AL Q ++ LA+D + ++ +L + +E+++L +
Sbjct: 3052 --------KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3103
Query: 4614 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR--- 4670
+ S LE + + + E S LD +A +G + L ++KE +
Sbjct: 3104 EKCSFLETKLQGIGHFQN--TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3161
Query: 4671 --------STGQPWQPDKML--------HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK 4714
S + KM+ LV + L+ ++Q LL+ + ++ E
Sbjct: 3162 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3221
Query: 4715 MCQQLERQLKSVK-------------EEQSKVNEETLPAEEKLKMY--------HSLAGS 4753
++LE +K E Q V ET ++L M+ L G
Sbjct: 3222 TIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3281
Query: 4754 LQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMV 4813
QD + + + ++ A E H + K L + + + + ++
Sbjct: 3282 QQDVNWLGQGL---IQSAAKSTSTQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALL 3335
Query: 4814 QSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL 4873
FQ + L W+ + ++ + ++ +I++ ++ Q + + +
Sbjct: 3336 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3395
Query: 4874 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQV 4930
+E EK E AD L +LS LD + L TR L I Q++++
Sbjct: 3396 K-REGEKIATTAE--PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3452
Query: 4931 FQAANDWLEDAQE-LLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 4989
+ N+WL ++ L+ G EE + H + ED ++ + LH V+
Sbjct: 3453 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQ 3509
Query: 4990 PLIKPTGKEDLEQKVASLELRSQ---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5046
L + +ED + + L+ + S ++ +LLQ+ + + E++ +
Sbjct: 3510 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3569
Query: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
N+ KLS+ S ++ S+ ++ SE + L E I+ ++ Q G +
Sbjct: 3570 NEVHDKLSKLS-VQDYSTEGLWKQQSELRVL-------QEDILLRKQNVDQALLNGLELL 3621
Query: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
K T + + + ++A +D K+ D V K E QL +L
Sbjct: 3622 KQTTGDEVLIIQDKLEAIKARYKDITKLSTD-----------VAKTLEQALQLARRL--- 3667
Query: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
++ EL T L+ + +L E Q GEE
Sbjct: 3668 ---HSTHEELCTWLDKVEVELLSYETQ--------------------VLKGEE------- 3697
Query: 5227 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQL 5286
+ + K +K+E K+ + + +N E+ + L
Sbjct: 3698 ----------ASQAQMRPKELKKEAKNNKALLDSLN------------------EVSSAL 3729
Query: 5287 EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKI 5346
EL R+ +EKM E E+Y L S+ Q E +R Q D+
Sbjct: 3730 LEL-----VPWRAREGLEKMVAEDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQA 3779
Query: 5347 KEVEQSKATSQE---LSRQIQKLAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCN 5402
+ E S T E +S +L +D T+ L K T +++ K + ++L
Sbjct: 3780 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSG 3835
Query: 5403 SKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN 5462
K+M + +K + + KK+ K+ + + + R +L +A S + ++
Sbjct: 3836 HKIMTACSEEEK---------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3886
Query: 5463 EMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521
E E + W+ E +++ LR+Q H+ L E E ++ M +
Sbjct: 3887 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3946
Query: 5522 LTSVYCTEKMSQQVAELGRET--EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
L + E S Q + +T ++++ +K R L +A +F ++ ++ +LE+
Sbjct: 3947 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4006
Query: 5580 AQATLTSP-----EVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA- 5633
L P EV + +KEQ+S +++ +ME L+P L ++ + E+++A
Sbjct: 4007 IVERLRQPPSISAEVEK--IKEQISENKNVSVDMEKLQP------LYETLKQRGEEMIAR 4058
Query: 5634 --SLPLCHAALRLQEEASRLQ------HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIE 5684
+A +Q++ ++ HT +++ V++ E++ + L I+
Sbjct: 4059 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4118
Query: 5685 GAH---REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
R++ED + S +++ Q E + ++I G QE++ + + L
Sbjct: 4119 DTQDFIRDLEDPGIDPSVVKQQQ---EAAETIREEIDGLQEELDIVINLGSELIAACGEP 4175
Query: 5742 TMLLTVTEVEGLAEGTEDLD----GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797
+ ++ L + L+ + A + V G + V G+
Sbjct: 4176 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK-- 4232
Query: 5798 TNSEISSPPACRSPSPVANTDASVNQDI---------AYYQALSAERLQTDAAKIHPSTS 5848
S SP+ +V Q I AY Q + ERL H +
Sbjct: 4233 ----------LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN------HQAEL 4276
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
++ E + + L +L+ W++L+ I +Q L AL ++Q +L + +
Sbjct: 4277 LLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4336
Query: 5909 EAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
E LSE G P E ++A+H L +++L Q + E + +L+ S +
Sbjct: 4337 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEE 4395
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ+ L VL +R + K ++Q L+ L RQ + + E ++L
Sbjct: 4396 ASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQ 4442
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL T+ L + P + QL + E K L + +L
Sbjct: 4443 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4502
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQ 6142
+ +Q + LK ++ L++++ ++ A E S D
Sbjct: 4503 SAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI-------- 4551
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE 6202
WL QA T + SL L Q + E K V S E+I+ +
Sbjct: 4552 NWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4610
Query: 6203 KPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL 6262
K DV+ + + ++ +WE + Q + + L + ++ ++ + ++L+
Sbjct: 4611 KQDVVLIK--------NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLM 4660
Query: 6263 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATS 6320
+ + + ++ S L+ N +++ +Q K ++S+ + +YD + T
Sbjct: 4661 EWL--------EESEKSLDSELEIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
L E+T LA D ++ + + + ++ + ++ + +
Sbjct: 4712 --------------RSLKEKTS--------LADDNLKLDDMLSELRDKWDTICGKSVERQ 4749
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ +E+ L G+ + + ++++ +L + D+ ++ + ++K
Sbjct: 4750 NKLEEAL-LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHK------- 4801
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
F++ + ++ ++Q + +E G R D V + MQELS ++ +
Sbjct: 4802 --AFQKELGKRTSSVQALKRSARELIEG-----SRDDSSWV-KVQMQELS---TRWETVC 4850
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHK 6560
+ S+++ L L ++ + L + L ++ + ++ ++ ++ L+D+HK
Sbjct: 4851 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHK 4909
Query: 6561 EYFQGLE 6567
E+ + LE
Sbjct: 4910 EFMKKLE 4916
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 507 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 558
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2443 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2502
Query: 559 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 614
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2503 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2562
Query: 615 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 661
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2563 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2622
Query: 662 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 718
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2623 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2682
Query: 719 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 768
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2683 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2742
Query: 769 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 821
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2743 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2802
Query: 822 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 878
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2803 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2858
Query: 879 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 938
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2859 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2916
Query: 939 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 996
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2917 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2975
Query: 997 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1053
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2976 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3032
Query: 1054 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1113
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3033 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3087
Query: 1114 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1171
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3088 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3147
Query: 1172 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1231
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3148 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3198
Query: 1232 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1272
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3199 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3257
Query: 1273 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1328
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3258 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3316
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1386
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3317 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3375
Query: 1387 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1444
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3376 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3435
Query: 1445 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1501
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3436 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3495
Query: 1502 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1561
+ + QS + + +++KL + + E++E + + L
Sbjct: 3496 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3555
Query: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1614
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3556 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3612
Query: 1615 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1672
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3613 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3672
Query: 1673 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1732
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3673 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3731
Query: 1733 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3732 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3791
Query: 1793 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3792 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3851
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3852 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3910
Query: 1907 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1964
E + + + + Q + + +D + L++ E AD L
Sbjct: 3911 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3970
Query: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2024
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3971 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4027
Query: 2025 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2078
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4086
Query: 2079 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2128
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4087 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4137
Query: 2129 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2184
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4138 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4197
Query: 2185 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2244
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4198 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4253
Query: 2245 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2301
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4254 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4310
Query: 2302 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2356
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4311 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 2357 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2415
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4430
Query: 2416 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4431 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4490
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4491 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4550
Query: 2535 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2594
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4551 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4606
Query: 2595 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2650
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4666
Query: 2651 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2709
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4667 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4726
Query: 2710 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2769
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4727 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4786
Query: 2770 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2828
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4787 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4846
Query: 2829 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2888
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4847 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4906
Query: 2889 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2948
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4907 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4963
Query: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4964 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5006
Query: 3009 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3054
QEI E++K+ + E F +++ V + K Y
Sbjct: 5007 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5040
Score = 203 bits (517), Expect = 5e-51
Identities = 144/436 (33%), Positives = 219/436 (50%), Gaps = 72/436 (16%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 57 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 114
Query: 80 GRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILY 139
GR R H + N+ AL +L+ R+ +KLVNI + DI DG P + LGL+WTIIL+
Sbjct: 115 GRM--RFHRLQNVQIALDYLKRRQ-------VKLVNIRNDDITDGNPKLTLGLIWTIILH 165
Query: 140 FQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTA 199
FQI ++ V+ E+ +AK+ LL W Q
Sbjct: 166 FQISDIH-------------------VTGESEDM------------SAKERLLLWTQQAT 194
Query: 200 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 259
GI ++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+
Sbjct: 195 EGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGV 253
Query: 260 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 319
RLLDPEDVDV PDEKS++TYV+ +P + +G +++ + + N V
Sbjct: 254 IRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYL 312
Query: 320 KREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHL 375
+ R M ER + L ++Y FK + + K K++ L
Sbjct: 313 IQWIRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKL 366
Query: 376 IQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREE 435
++ G++ L Q ++ +W G + + E ALR E
Sbjct: 367 LEIWIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPE 408
Query: 436 ITVQQVHEETANTIQR 451
+ ++ ++ AN +QR
Sbjct: 409 VERLEMLQQIANRVQR 424
Score = 170 bits (430), Expect = 7e-41
Identities = 619/3344 (18%), Positives = 1264/3344 (37%), Gaps = 595/3344 (17%)
Query: 5604 LLSEMESLKPKVQAVQLCQS-ALRIPED-VVASLPLCHAALRLQEEASRLQHTAIQQCNI 5661
+L ++L+P+V+ +++ Q A R+ D V+ L A LQ ++ RL+ + +Q N
Sbjct: 398 MLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE-SGVQFQNE 456
Query: 5662 MQAA--VVQYEQY-EQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIK 5718
+ A +++ E Q + +Q LI+G + + + +L Q++
Sbjct: 457 AEIAGYILECENLLRQHVIDVQILIDGKYYQAD--------------------QLVQRVA 496
Query: 5719 GYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEG-------------TEDLDGELL 5765
+++I +L ++C + K + T T + G+ + T L L
Sbjct: 497 KLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLT 556
Query: 5766 PTPSAHPSVVMMTAGRCHTLLSPVTE--------------ESGEEGTNSEISSPPACRSP 5811
P+ ++ +++G L VT SG E + + R P
Sbjct: 557 PSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKP 616
Query: 5812 SPVAN------TDASVN----QDIAYY---QALSAERLQ--TDAAKI------HPSTSAS 5850
++ T+ +N QD+ + + +R + +D + H + +
Sbjct: 617 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA 676
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTL---YEAL----ERQQKYQDSLQS 5903
E +E L+ AK+ ++Q + LK +EK L Y L Q+++ D+L +
Sbjct: 677 IEEFESSLKE---AKISEIQMT-APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN 732
Query: 5904 ISTKM--EAIELKLSESPEPGRSPESQMAE-------HQALMDEILMLQDEINELQSSLA 5954
++ E I L E E + H LM E+ ++ I +Q +A
Sbjct: 733 FVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQE-IA 791
Query: 5955 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK------LNDQLEE- 6007
E+L+ E+ A +L +++ + + S I Q ++E ND E
Sbjct: 792 EQLLLENHPA----RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 847
Query: 6008 ---QRQEQALQR-YRC--------------EADELDSWLLSTKATLDTALSPPKEPMDME 6049
+ + A+QR Y C E+ E LL K+T+ + K + ++
Sbjct: 848 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLK 907
Query: 6050 AQLMDCQNMLVEIEQKVVA---LSELSVHNEN-LLLEGKAHT------------------ 6087
+ DC + I K + E++++ ++ +L +H
Sbjct: 908 PRNSDCP-LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 966
Query: 6088 -------KDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ---------EKEESDV 6131
EA LA ++ + ++L L H+ +NM+ S+V
Sbjct: 967 CFTVPPPNKEAVDLANRIEQQYQNVLTLW---HESHINMKSVVSWHYLINEIDRIRASNV 1023
Query: 6132 DLTATQSPGV-QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ 6190
T PG Q+ L+ ++ + + S + Q ++ + + + +E+L
Sbjct: 1024 ASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS 1083
Query: 6191 HSAAETSGDAGEK--PDVLSQELGMEGEKSSAEDQMR--MKWESLHQEFS--TKQKLLQN 6244
E +V + L +E + Q+R ++ + LH+ T+Q+ L+
Sbjct: 1084 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 1143
Query: 6245 VLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 6302
LE+ ++ + + ++ S VPT +S + +L +NQ + S+ K
Sbjct: 1144 ELERLKDDLGTITNKCEEFFSQAAA-SSSVPTL-RSELNVVLQNMNQVYSMSSTYIDKLK 1201
Query: 6303 RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEM 6362
++ L+ A + E +L A++ ++ N E L +K+ E+
Sbjct: 1202 TVNLVLKN-----TQAAEALVKLYETKLCEEEAVIADKN-----NIENLISTLKQWRSEV 1251
Query: 6363 DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQ----QILNF 6418
D+ + +F A + I D + L ++ Q+ ER Q QI N
Sbjct: 1252 DEKRQVF-HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1310
Query: 6419 QNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRG 6476
DL+ + SL KY L + +Q Q + + + K + + K
Sbjct: 1311 LRDLEGIGKSL---KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1367
Query: 6477 DKLQVEQPSMQELSKLQDMYDELMM-----------IIGSRRSGLNQNLTLKSQYERALQ 6525
+++++Q M E K + Y + ++ S++ + ++S + +Q
Sbjct: 1368 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1427
Query: 6526 DLADL---------LETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ DL L T K AGD + +EE + L ++ KE+ +
Sbjct: 1428 EFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEEEKSLEEEKKEHVEKA---------- 1475
Query: 6577 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV 6636
KE Q + ++ S LK A K G +S +E+S + E
Sbjct: 1476 ----------KELQ---KWVSNISKTLKDAEKAGKP------PFSKQKISSEEISTKKEQ 1516
Query: 6637 VESSIPSVGL-VEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLE 6695
+ ++ ++ L + ++ D++ D NE + K + L + LL S S
Sbjct: 1517 LSEALQTIQLFLAKHGDKMTDE---------ERNELE-KQVKTLQESYNLLFSES----- 1561
Query: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6755
L QL E S K+ +++ + + Y+ + + L ++RL Q++
Sbjct: 1562 --LKQLQESQTSGDVKVEEKI-----VAERQQEYKEKLQGICDLLTQTENRL-IGHQEAF 1613
Query: 6756 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATLRSEL 6810
+ ++ + + E K++ + + V+ L+ L + D A + +L
Sbjct: 1614 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1673
Query: 6811 SRIDSQWTDLLTNIPAVQEKLHQLQMDKL-------------------PSRHAISEVMSW 6851
+ + L N+ A Q K ++DK+ S+ I ++ W
Sbjct: 1674 NEAKIKCEQL--NLKAEQSKK---ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1728
Query: 6852 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYK---GFKIDINCKQLTVDFVNQ--SVLQI 6906
+S ++ ++ K I H K G + ++N L D Q + +
Sbjct: 1729 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1788
Query: 6907 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTW 6966
+Q + ++ Q A+ + Q Q L+ ++ Q L E + + N++ LK
Sbjct: 1789 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP--EEKEKLQKNMKELKVH 1846
Query: 6967 FET----QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLAL 7017
+ET EK++K H + ++ +A D + E ++ E+E+E +E NGL
Sbjct: 1847 YETALAESEKKMKLTHSLQEELEKFDA--DYTEFEHWLQQSEQELENLEAGADDINGLMT 1904
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLK---SVLDQWSSHKVAFDKINSY 7074
+++ S V+S +L + + ++ K K +D ++H+ K++
Sbjct: 1905 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD-- 1962
Query: 7075 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 7134
++ RFR L + +NL++L D + E + G + L+ C
Sbjct: 1963 -----HATDRFRSLYSKCNVLG---NNLKDLVDKYQHYEDA--SCGLLAG--LQACEATA 2010
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7194
++ L+ + + + QL+ +KAL + Q+ +L
Sbjct: 2011 SKHLSEPIAVDP-------KNLQRQLEETKAL--------------QGQISSQQVAVEKL 2049
Query: 7195 LKAATNKDIADDEVATWIQDCNDLLKGL----GTVKDSLFFLHELGEQLKQQVDASAASA 7250
K A ++ D + + ND+ K L G +D ++E E+L
Sbjct: 2050 KKTA---EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL----------- 2095
Query: 7251 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL--QGQD 7308
Q++L++ L S+Q G L+ + W+ E L QGQ
Sbjct: 2096 ----QITLTRSL------------SVQDG----------LDEMLDWMGNVESSLKEQGQV 2129
Query: 7309 PSHSSDLSTIQERM----EELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 7364
P +S+ L I + +++ G+ ++M + + E + + K M++L+
Sbjct: 2130 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK-MKDLSA 2188
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7421
+S S + E +K++ + + F EK +T++E +T+ V++ G L
Sbjct: 2189 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE--TKTQALTEVDVPGKDVTELS 2246
Query: 7422 QQRAHELFQ-AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7480
Q + E ++LHS++ + + G D+ K LS +++ +
Sbjct: 2247 QYMQESTSEFLEHKKHLEVLHSLL---KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2303
Query: 7481 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS-----YLPMSGLGSVPIPLQQARTLFDE 7535
++++ + S Q ++ + + L+ W+ E + P G + L+ + L ++
Sbjct: 2304 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2363
Query: 7536 VQFKEKVFLRQQGSYI-------LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM 7588
K + S I K + GA + +E W A+
Sbjct: 2364 WSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW--ANK 2421
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
L KK + + +E + D + +L T KL ++ EE A +++
Sbjct: 2422 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA----QEESSAMMQWLQKMNK 2477
Query: 7649 AVGSW------TD--------------------DLTQLSLLKDTLSAYISAD----DISI 7678
W TD ++ ++ LKD L+ + + +
Sbjct: 2478 TATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPR 2537
Query: 7679 LNERVELLQRQWEELCHQLSLRRQQ-IGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7737
+ + + +W+EL +QL++ RQQ + E N F +L +WL + E VS G
Sbjct: 2538 WKQMLTEIDSKWQEL-NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2596
Query: 7738 ILIE-EMIEKLKKDYQ---EEIAIAQENKIQLQQMGERLAKASHESKASE--IEYKLGKV 7791
+ I+ M+ ++ Q +E A + QL G+ + E + ++ +L V
Sbjct: 2597 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2656
Query: 7792 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI 7851
+W L ++ R + + +V Q + SL L+ ++++L+ + S + + +
Sbjct: 2657 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV-STHPDAM 2715
Query: 7852 QRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD-----------SIQQ 7900
++L Q+++++I++ + LCE L AE ++Q
Sbjct: 2716 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2775
Query: 7901 ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
N + ++ CA S + ++ R +Q +LD K E+ + P S+ +
Sbjct: 2776 KAENHVQHLQSACASSHQ----FQQMSRDFQAWLDT--------KKEEQNKSHPISAKL- 2822
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN 8020
V + +K + F + + E + L + + +L+ ++ WD
Sbjct: 2823 -DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2881
Query: 8021 LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH-FSECDVQAKIKQLK 8079
K+V +LK + + +++ +++ W+ + L I+ + + I +LK
Sbjct: 2882 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLK 2941
Query: 8080 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK- 8138
+ Q+E+ + +E + L+ E +D ++ DE + Q+V E+ H K
Sbjct: 2942 SLQKEMDQHFGMVELLNNTANSLLSVCE-IDKEVVT---DENKSLIQKVDMVTEQLHSKK 2997
Query: 8139 --LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS 8196
L + E +E + + A L HD L Q SN L++ Q +
Sbjct: 2998 FCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDS-----LGSQAYSNKYLTMLQTQQK 3052
Query: 8197 ERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDV 8256
S+ ++ H DL++ L + E D K G SDV
Sbjct: 3053 ---------SLQALK----HQVDLAKRLAQDLV-------VEASDSK--------GTSDV 3084
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR------- 8309
++ ++ + +HS L Q+ + L+ I +N IR
Sbjct: 3085 LLQ-------------VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3131
Query: 8310 -------SKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 8356
S P G + +T + K ++K L +S D+ + + EE+ P
Sbjct: 3132 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3191
Query: 8357 V----NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8412
V +L + Q ++DR A ++E +++ +++ ++F S L L E
Sbjct: 3192 VGIKRDLEALSKQCNKLLDR-------AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3244
Query: 8413 EELEQLQRLELSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQ--ADSKES 8469
E E + + T+ TI Q+ K QK ++ + +N Q A S +
Sbjct: 3245 EHEESQGPVGMETE--TINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3302
Query: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
+ L+ L +N RW + + + LQ+AL+ C F + LL + + +
Sbjct: 3303 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3362
Query: 8530 PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHV 8589
P + Q ++L+Q + +S + V + ++ AE D ++ +++ +
Sbjct: 3363 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE--KIATTAEPADKVKILKQLSL 3420
Query: 8590 IGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADE 8629
+ +R + LL + ++LE + V+ + + L+ W + E
Sbjct: 3421 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE 3464
Score = 159 bits (401), Expect = 2e-37
Identities = 417/2207 (18%), Positives = 833/2207 (37%), Gaps = 317/2207 (14%)
Query: 6668 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1038 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1095
Query: 6728 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6771
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1096 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1155
Query: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6831
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1156 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1200
Query: 6832 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6889
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1201 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1251
Query: 6890 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 6943
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1252 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1311
Query: 6944 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1312 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1371
Query: 7002 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7059
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1372 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1431
Query: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7108
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1432 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1491
Query: 7109 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7146
EK + S QK S KE +T L +K +
Sbjct: 1492 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1551
Query: 7147 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7190
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1552 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1611
Query: 7191 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1612 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1665
Query: 7244 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7293
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1666 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1725
Query: 7294 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7318
W+ ++ + H + T
Sbjct: 1726 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1785
Query: 7319 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7364
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1786 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1845
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7422
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1846 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1905
Query: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7470
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1906 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1965
Query: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7530
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1966 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2024
Query: 7531 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7583
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 2025 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2081
Query: 7584 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7641
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2082 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2141
Query: 7642 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7698
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2142 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2201
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2202 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2256
Query: 7759 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7817
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2257 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2315
Query: 7818 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7867
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2316 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2373
Query: 7868 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7905
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2374 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2433
Query: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 7964
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2434 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2493
Query: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8022
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2494 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2553
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--VQAKIKQLKA 8080
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2554 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2613
Query: 8081 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2614 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2673
Query: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2674 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2729
Query: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSDV 8256
V E DLS ++ +A S EG + KD
Sbjct: 2730 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKD------------ 2772
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQIQQTENIIRSKTP 8313
+ + E +V+ ++A A Q +Q+ + D++ + Q + I +K
Sbjct: 2773 -VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD 2823
Query: 8314 TGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR 8372
L +K + K L S + ++ E+ L + + S + L +T
Sbjct: 2824 VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----N 2878
Query: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
W+ Q +E ++K++L+K ++ + ++W W+ + LE+ ++ D E
Sbjct: 2879 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGEN 2935
Query: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 8492
I KLK LQK +D ++ +N + + + D + + D V L
Sbjct: 2936 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2995
Query: 8493 WRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
+ L++ + + F E+S L E +D + SN +LQ K L
Sbjct: 2996 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3055
Query: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8608
+KH++ L QD+ + +++GT + +V I L ++V L
Sbjct: 3056 ALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFL 3109
Query: 8609 E-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 8649
E KL + Q + S DELD+ V GR QK
Sbjct: 3110 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3152
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 373 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 431
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4629 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4677
Query: 432 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 485
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4678 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4721
Query: 486 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 531
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781
Query: 532 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 591
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4782 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4836
Query: 592 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 645
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896
Query: 646 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 698
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4897 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956
Query: 699 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 753
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4957 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5016
Query: 754 QD----LEDIEQRVPVMDAQYKIITKT 776
+ +E++ ++ P +D +TKT
Sbjct: 5017 AEHQTFMEEMTRKQPDVDK----VTKT 5039
Score = 33.5 bits (75), Expect = 9.5
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 382 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 433
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4722 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781
Query: 434 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 490
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4782 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4840
Query: 491 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 542
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4841 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4900
Query: 543 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 598
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4901 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4944
Query: 599 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 658
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4945 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4987
Query: 659 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 718
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4988 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5038
Query: 719 EY 720
Y
Sbjct: 5039 TY 5040
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 336 bits (861), Expect = 7e-91
Identities = 707/4022 (17%), Positives = 1549/4022 (38%), Gaps = 508/4022 (12%)
Query: 1235 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1292
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1325 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1381
Query: 1293 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1349
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1382 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1440
Query: 1350 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1405
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1441 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1498
Query: 1406 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1460
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1499 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552
Query: 1461 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1513
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
Query: 1514 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1573
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1613 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1669
Query: 1574 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1633
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1670 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1711
Query: 1634 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1680
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1712 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1767
Query: 1681 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1720
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1768 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1827
Query: 1721 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1780
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1828 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1885
Query: 1781 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1835
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1886 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1945
Query: 1836 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1883
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1946 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 2002
Query: 1884 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1937
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 2003 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2061
Query: 1938 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1995
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2062 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2121
Query: 1996 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2122 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2181
Query: 2056 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2182 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2241
Query: 2115 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2169
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2242 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2287
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2223
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2288 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2341
Query: 2224 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2276
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2342 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2400
Query: 2277 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2335
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2401 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2442
Query: 2336 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2395
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2443 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2501
Query: 2396 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2455
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2502 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2535
Query: 2456 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2515
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2536 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2572
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2573 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2630
Query: 2576 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2631
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2631 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2690
Query: 2632 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2689
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2691 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2750
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2751 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2809
Query: 2750 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2800
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2810 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2860
Query: 2801 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2857
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2861 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2919
Query: 2858 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2917
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2920 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2961
Query: 2918 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2977
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2962 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3019
Query: 2978 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3037
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 3020 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3079
Query: 3038 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3078
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3080 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3139
Query: 3079 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3138
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3140 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3199
Query: 3139 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3198
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3200 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3253
Query: 3199 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3253
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3254 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3307
Query: 3254 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3308
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3308 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3367
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3368
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3427
Query: 3369 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3428
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3428 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3487
Query: 3429 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3482
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3488 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3547
Query: 3483 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3539
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3548 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3607
Query: 3540 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3597
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3608 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3665
Query: 3598 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYR-DEVEEVGARAQEILDESHV 3656
+ R + +++ WL E + E + +E + R +E+ E+
Sbjct: 3666 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3725
Query: 3657 NSRMGCQATQLTS-----------------------RYQALLLQVLEQIKFLEEEIQSLE 3693
N + +++S RY+ + + ++++ ++ I +
Sbjct: 3726 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3785
Query: 3694 ESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3750
+ + + + W T K + + + D+ + +K T+E+L + ++
Sbjct: 3786 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKDIID 3840
Query: 3751 SAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKC 3810
+ G + + E E + ++K++ ++ + + ++ LE+ L +F +
Sbjct: 3841 DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3900
Query: 3811 KALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE 3870
+ L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G LLE
Sbjct: 3901 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3960
Query: 3871 LV-------------------------------------QDVTLKDKIDQLQSDYQDLC- 3892
L Q DKIDQ+ + +
Sbjct: 3961 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4020
Query: 3893 -------------------SIGKAMMEEIAGFEDRLNNLQMKGDTLIGQC--------AD 3925
S K + ++ + L+ +G+ +I + A
Sbjct: 4021 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4080
Query: 3926 HLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA 3979
+Q KL Q N+H ++ + + A++ + H+S T++ Q
Sbjct: 4081 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIKDTQD 4133
Query: 3980 WLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLSNASV 4033
++ ++ P ++PS + AE I++ LQE+ ++L L + C + V
Sbjct: 4134 FIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPDKPIV 4191
Query: 4034 KTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH 4089
K + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4192 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4251
Query: 4090 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHLNDQ- 4146
++LE + + ++K F + +Q + + + L KK EES +H + L +
Sbjct: 4252 TDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4309
Query: 4147 --WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHL 4204
W L + N + E L + ++ + +L + A+ +
Sbjct: 4310 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4369
Query: 4205 EALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK 4262
E K L + + +E + +IE ++ ++ + L QRW + + +
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4429
Query: 4263 RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4322
++ Q L + ++L +W + + ++ + P+ A+ L H+ +C+
Sbjct: 4430 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAA 4489
Query: 4323 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4382
EAK+ KSL++ +++A + I + +++ + + + +R+ L +AL+
Sbjct: 4490 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4549
Query: 4383 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4442
+F ++ + + Q E+ + L+ D V Q+ K + +++ ++ L
Sbjct: 4550 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIEL 4609
Query: 4443 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4502
G L +Q+ + L +QS ++ V+Q+ R + L+ K F E + K
Sbjct: 4610 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4669
Query: 4503 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4562
WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4670 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4729
Query: 4563 NEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L +E
Sbjct: 4730 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789
Query: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTGQPWQ 4677
Q V D ++ ++L D +A E+ +V L + EG R W
Sbjct: 4790 QLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WV 4846
Query: 4678 PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEET 4737
+M L T + + + + + LE +E + L L + EQ+
Sbjct: 4847 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLRFHGV 4904
Query: 4738 LPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792
LP +E + + L++ L + T + + P + +H I +
Sbjct: 4905 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4964
Query: 4793 ELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE 4852
+ + + + S + I Q + L WL+ + L+ D + + I +E
Sbjct: 4965 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEVIPQE 5019
Query: 4853 IRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRT 4912
I +++ E Q+ + M + +K TK + +AD + + LD R
Sbjct: 5020 IEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRF 5078
Query: 4913 RQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLAGNGL 4952
++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5079 PASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDF 5138
Query: 4953 DV 4954
D+
Sbjct: 5139 DI 5140
Score = 322 bits (825), Expect = 1e-86
Identities = 858/4699 (18%), Positives = 1838/4699 (39%), Gaps = 637/4699 (13%)
Query: 3186 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3243
E++ + +QD L+ ++M + + DLP+ + ++V I +E L K
Sbjct: 642 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 701
Query: 3244 AQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWM 3303
Q+ ++ ++ +L SQY L N ++ + LD + HN S EL W+
Sbjct: 702 EIQMTA--PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELI-WL 755
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
+ +Y + ++ + E + + Q++E +K + E +L P +
Sbjct: 756 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE-NIKSVQEIAEQLLLENHPARL 814
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEA-----N 3418
TI+ +++ W+ +L C+ +E + + T+Y F + D+ EA N
Sbjct: 815 -TIEAYRAAMQTQWSWILQL---CQC-VEQHIKENTAY------FEFFNDAKEATDYLRN 863
Query: 3419 LNESERQHAELRDKTTMLGKAKLL-------NEEVLSYSSLLET--------IEVKGAGM 3463
L ++ ++ D+++ + K + L EE+L Y S + I++K
Sbjct: 864 LKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 922
Query: 3464 TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQE----- 3518
T + ++ + + YR I+ + K ++ V + ++ K G E
Sbjct: 923 DCPLKTSIPIKAICD-YRQIEI----TIYKDDECVLANNSHRAKWKVISP-TGNEAMVPS 976
Query: 3519 ---------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPS 3569
+E +D + +E T + L+N + R + S
Sbjct: 977 VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVAS 1036
Query: 3570 ---GIPQAEDRALESLRQDWQAYQHRLSETR-------TQFNNVVNKLRLMEQKFQQVDE 3619
+P + L +L+ ++ + E++ TQ VN + Q E
Sbjct: 1037 IKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK------QYYQE 1090
Query: 3620 WLKTAEEKKWHEEV-TAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQV 3678
LK+AE ++ E V Y EV + R + D R + L + ++
Sbjct: 1091 LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHES----VFRI 1146
Query: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGK-------- 3730
EQ K L++E++ L++ ++++ + + S +V T +++ V+
Sbjct: 1147 TEQEK-LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 1205
Query: 3731 ----KLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3786
KLKT+ ++LK+ + +L+K K L E EA K ++ L
Sbjct: 1206 TYIDKLKTVNLVLKNTQAAEALVKLYETK-------LCEEEAVIADKN------NIENLI 1252
Query: 3787 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK-YK 3845
ST++ QW +E E V + EL + KA + +K
Sbjct: 1253 STLK------------------------QWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1288
Query: 3846 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGF 3905
+ ++ L + +EK + L+E Q+V + Q+ + +DL IGK++ +
Sbjct: 1289 TYKERDLDFDWH----KEKADQLVERWQNVHV-----QIDNRLRDLEGIGKSLKY----Y 1335
Query: 3906 EDRLNNLQMKGDTLIGQCADHLQAKLKQNV--HAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
D + L D I Q + Q K+++N ++ T+ + + + M QS E
Sbjct: 1336 RDTYHPL----DDWIQQ-VETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1390
Query: 3964 LQKHVSRQD-TLQQCQAWLSAVQPDLEPSPQPPLSR----AEAIKQVKHFRALQEQARTY 4018
QK+ + T++ + + ++ + P+ R + A ++ F L+ +
Sbjct: 1391 CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL 1450
Query: 4019 LDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA 4078
+ L+ + S+K ++ + E+ ++ + +A+ L Q W S + L+DA
Sbjct: 1451 VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-QKWV------SNISKTLKDA 1503
Query: 4079 DQQLQN--MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE 4136
++ + K++ S E++ + +S+ ++ +K +K+T +E +
Sbjct: 1504 EKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG---------DKMTDEERNEL 1554
Query: 4137 HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV----EVFLEKFTTEWDNL 4192
K++ L + + L +S L++ ++ Q + D +V + + EK D L
Sbjct: 1555 EKQVKTLQESYNLLFSES----LKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1610
Query: 4193 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4252
+++ H EA ++ +KY + +++ QK ++ E+VK + L++
Sbjct: 1611 TQTENRLIG-HQEAFMIGDGTVELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKE 1667
Query: 4253 RWFQLED----LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4308
+L LI++K+ + E+LN+ + ++ E + A+K+
Sbjct: 1668 NGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK------ELDKVVTTAIKEET---- 1717
Query: 4309 AQNLLMDHLAICSELEAKQMLLKSLI---KDADRVMADLGLNERQVIQKALSDAQSHVNC 4365
+ +A +LE + +++L+ + D+ G +QVI++ + Q
Sbjct: 1718 ------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG- 1770
Query: 4366 LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4425
+G+ + L + Q + Q +K+ ++ K
Sbjct: 1771 -KSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKVK------------AQHEKII 1815
Query: 4426 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL------QKC 4479
QA + Q+ L QG+ L E EK ++ ++EL+ Y++ L K
Sbjct: 1816 SQHQAVIIATQSAQVLLEKQGQYLSPE----EKEKLQKNMKELKVHYETALAESEKKMKL 1871
Query: 4480 SHRLQE-LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE----LHTQLAKY 4534
+H LQE LEK F D+ + HWL+Q++ E+ + ++ L T+L +
Sbjct: 1872 THSLQEELEK-------FDADYTEFEHWLQQSE----QELENLEAGADDINGLMTKLKRQ 1920
Query: 4535 QNILEQSPEYENLLLTLQRTGQTILPSLN--------EVD----HSYLSEKLNALPRQFN 4582
++ E ++ L + +G +L + +VD H + KL+ +F
Sbjct: 1921 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR 1980
Query: 4583 VIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ 4642
+ + +++ + +Y + + L+ L+A SK ++ + +LQ
Sbjct: 1981 SLYSKCNVLGNNLKDLV---DKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2037
Query: 4643 ---DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK------MLHLVTLYHRLKR 4693
+ +A+ +++ AV++L + E P K + +V Y L +
Sbjct: 2038 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2097
Query: 4694 QTEQRVSLLEDTT----SAYQEHEKMCQQLERQLKSVKEE-QSKVNEETLP--AEEKLKM 4746
+R L+ T S ++M + S+KE+ Q +N L + + +
Sbjct: 2098 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2157
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+AG + ++V +E DP + +++ + ET+
Sbjct: 2158 EQDIAGRQSSINAMNEKVKKFMETT----DPSTASSLQAKMKDLSARFSEASHKHKETLA 2213
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
+ E + ++ +S L K + V D+ +D+ E + +Q E
Sbjct: 2214 KMEE-LKTKVELFENLSEKLQTFLETKTQALTEV--DVPGKDVTELSQYMQESTSEFLEH 2270
Query: 4867 LRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQR 4926
+ + L KE + A + LS+ ++++ ++ ++ +T Q
Sbjct: 2271 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2330
Query: 4927 YYQVFQAANDWLEDAQE---LLQLAGNGLDVESAEENLKSHMEFFSTE----DQFHSNLE 4979
+ + ++ W+++ + ++Q + D+ + E+ K E +S + + +++
Sbjct: 2331 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2390
Query: 4980 ELHSLVATLDPLIKP-----------------TGKEDLEQKVASLELRSQRMSRDSGAQ- 5021
L +L++ + K T E+ ++ G +
Sbjct: 2391 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYED 2450
Query: 5022 -----VDLLQRCTAQWHDYQKAREE---VIELMNDTEKKLSEFSLLKTSSSHEA-EEKLS 5072
D + + QKA+EE +++ + K +++ + EA + ++
Sbjct: 2451 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2510
Query: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTT-VWQRWTRLRAVAQDQ 5131
++K+ + + K+ L++K ++L + D +A + M T + +W L + D+
Sbjct: 2511 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2570
Query: 5132 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV---- 5187
++ LE++ + T F ++ +L EK +L L +
Sbjct: 2571 QQKLEESSNNLTQFQT-----------VEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2619
Query: 5188 --LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLM----QEITAMQDRCLNMQEKVK 5241
+++ Q+ A + + L+ G PGE+P L +++ A+ + ++ ++
Sbjct: 2620 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2679
Query: 5242 TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI------EIDAQLEELQILLTE 5295
+ Q + ++ + S+ + + L + ++ QLE Q + E
Sbjct: 2680 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2739
Query: 5296 ATNHRQNI-------EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIK 5347
++ I E ++ KE+YL +ELS QL + K + + ++ ++
Sbjct: 2740 IQQEKKQIKVAQALCEDLSALVKEEYL------KAELSRQLEGILKSFKDVEQKAENHVQ 2793
Query: 5348 EVEQSKATS---QELSRQIQK---LAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5401
++ + A+S Q++SR Q K+ + AK D + D K + L
Sbjct: 2794 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA- 2852
Query: 5402 NSKLMELDAAVQK--FLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5459
S + E A + L+ G L ++ + +Q + R +KL ++
Sbjct: 2853 QSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2912
Query: 5460 EYNEMLELILKWIEKAK----------VLAHGTIAWNSASQLREQYILHQTLLEESKEID 5509
+Y E +E + WI+K + A G + L+++ H ++E
Sbjct: 2913 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA 2972
Query: 5510 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5569
+ L ++ E + T++ + ++ TE+L K L+N+ K+ ++ E
Sbjct: 2973 NSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KFCLENMTQKFKEFQEVSKE 3027
Query: 5570 LKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ-AVQLCQSALRI 5627
K+ LQ A EQ + + + L+ Q +++LK +V A +L Q +
Sbjct: 3028 SKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVE 3085
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
D + + + +E S L ++C+ ++ + ++ ++ +
Sbjct: 3086 ASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD 3145
Query: 5688 REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5747
E++ + + LQ Q + +K++ + N CKM+ + + L+ +
Sbjct: 3146 DELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGI 3205
Query: 5748 -TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE-----ESGEEGTNSE 5801
++E L++ +LL A V T R S + E + EE S+
Sbjct: 3206 KRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3261
Query: 5802 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5861
PV ++NQ + ++ E ++ K Q + + +
Sbjct: 3262 ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3311
Query: 5862 ATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS-ISTKMEAIELKLS 5916
+T L D+ W+TL ++++ L EAL ++QD+L+S +S ++ EL +
Sbjct: 3312 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3371
Query: 5917 ESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE-----ADPAEQLA 5971
+ P P ++ +A + E +LQ +++ +S++ E++ E A+PA+++
Sbjct: 3372 QKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVIKREGEKIATTAEPADKVK 3424
Query: 5972 LQSTLTVLAERMSTIRMKASGKRQLLE-------------EKLNDQLE--EQR------- 6009
+ L++L R + KA + + LE E LN+ L E+R
Sbjct: 3425 ILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPI 3484
Query: 6010 --QEQALQRYRCEADELDSWLLSTKATLDTALS--------PPKEPMDMEAQLMD-CQNM 6058
Q L+ + L+ +++ L A+S +E DM +D Q
Sbjct: 3485 GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW 3544
Query: 6059 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QLAGKLRRL----------- 6101
+EI++K + SEL + L K +DE E ++ KL +L
Sbjct: 3545 YIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3601
Query: 6102 --KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6159
+ L LQ + ++ N+ E T + +Q+ L + + + S
Sbjct: 3602 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3661
Query: 6160 LQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG-MEGEKS 6218
K LEQ L L R + S EE+ E ++LS E ++GE++
Sbjct: 3662 TDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV--------ELLSYETQVLKGEEA 3709
Query: 6219 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S Q +M+ + L +E + LL + L + +L P R G+ + +D
Sbjct: 3710 S---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWRAREGLE----KMVAEDNE 3761
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 6338
+ D + Q EE+ + +I Q+ A +W+ + E++L +
Sbjct: 3762 RYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3813
Query: 6339 EETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
E+ +T F EIL K++ +++ K+ + A E + + ++ L +L
Sbjct: 3814 EQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTACSE--EEKQSMKKKLDKVL 3869
Query: 6392 GRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADNKYIILQKLANVFE-QPVA 6449
+ + ++R Q+ ER Q ++N F + L+ L + + II Q A E + +
Sbjct: 3870 KNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3928
Query: 6450 EQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQELSKLQD-MYDELMMIIG 6504
+Q E +Q + + E I ++ + G +L P S+QE D +Y ++ +
Sbjct: 3929 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 3988
Query: 6505 SRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQ 6564
R L++ ++ +Q+ + + + LE E++ I + E+I++ + ++K
Sbjct: 3989 KRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSV 4047
Query: 6565 GLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVE--LEYILETWSH 6622
+E L ETL Q E++A++ K + V+ L+ ++ W +
Sbjct: 4048 DMEKLQPLYETL------------KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4095
Query: 6623 L----DEDQQELSRQLEVVE-------SSIPSV----GLVEENEDRLIDRITLYQH---- 6663
+ +E + +L +E+ E S I ++ + + ED ID + Q
Sbjct: 4096 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4155
Query: 6664 --LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHR 6718
++ ++ Q +L V++ G L+ + D ++ +++L W S + +
Sbjct: 4156 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4215
Query: 6719 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV 6778
LE ++ +YQ + W+ A +L + + +LE V+ + +F E
Sbjct: 4216 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTDLETVKQQIEELKQFKSEA 4271
Query: 6779 DAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 6834
Q ++ L+ +LL LKKV D T++ L + W L I Q KL
Sbjct: 4272 -YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4329
Query: 6835 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCK 6892
+ +HA+ E+++W++ E ++ + + +G KAI L K+ + D+
Sbjct: 4330 LLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKAIEIELAKHHVLQNDVLAH 4384
Query: 6893 QLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q TV+ VN++ + +ES ++ ++ +L +N+ WQ + ++ Q L+G L
Sbjct: 4385 QSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ ++ L+ W E+ L +G + + L ++ +AKE+ + +
Sbjct: 4441 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4500
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
Q G ++ + + + + L + W +++ + + K L+ L+ +
Sbjct: 4501 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4560
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++L +A +L+ + L+ V Q+D + +++ + + L
Sbjct: 4561 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4620
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKALLQLWQRYKDYSKQCAST 7183
+ N L V RW +++ + E+ +S +K + W + ++ ++ +
Sbjct: 4621 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4680
Query: 7184 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
+ + + N+ D++ T + + K LG + G LK++
Sbjct: 4681 LDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK- 4728
Query: 7244 DASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQAGVLDYETFAKSLEALEAW 7296
+++ D L L L L +C ++Q L+ +L F +L+AL W
Sbjct: 4729 -----TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDW 4783
Query: 7297 IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7356
+ E L P H D+ + ++ K + + L L ++
Sbjct: 4784 LYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4842
Query: 7357 K-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7411
+MQ L+ W + + + + ++L++ L Q + F +E+L + EQ L
Sbjct: 4843 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4902
Query: 7412 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLL 7469
+ + L H+ F ++ ++ L+ G +L D +T++
Sbjct: 4903 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4962
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-EVSYLPMSGLGSVPIPLQQ 7528
+++ V+ A+Q + + S + +E+ E L WL + L +P +++
Sbjct: 4963 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 5022
Query: 7529 ARTLFDEVQ-FKEKVFLRQ 7546
+ L E Q F E++ +Q
Sbjct: 5023 VKALIAEHQTFMEEMTRKQ 5041
Score = 312 bits (799), Expect = 1e-83
Identities = 770/4311 (17%), Positives = 1668/4311 (38%), Gaps = 501/4311 (11%)
Query: 1482 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1535
S S + ++ V Q + L S E+E + +++ + R++ + + Q
Sbjct: 1070 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1129
Query: 1536 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1594
IR E H T L ++ ++ +++L I EF + A + + +E
Sbjct: 1130 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1189
Query: 1595 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1654
VLQ + S+SS + V+ Q A AL + YE L
Sbjct: 1190 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1238
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
E ++A +E +S+ W R +V+ + Q+ AL++E+
Sbjct: 1239 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1276
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
K + + +F + D+ K +QL ERW+++ I+ R+ L+ +
Sbjct: 1277 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1330
Query: 1773 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1824
+ + + WI+ +++TT I ++Q L + K +E+E K+
Sbjct: 1331 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1385
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1881
++ Q + + + + +L + +A + + V+RR++ S + EF+
Sbjct: 1386 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1441
Query: 1882 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1938
+ ++ + Q ++ A +S+ + E + +E++ + ++ AK L+ ++ L
Sbjct: 1442 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1501
Query: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1998
A+ K S+Q+ S ++++ + E++ L T Q L + K
Sbjct: 1502 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1543
Query: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2057
++ TD+ER N+LE ++ + + L + KQ+ +
Sbjct: 1544 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1581
Query: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
+ +V+ +I E + + G+ DL+ + +N +++ + + ++
Sbjct: 1582 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1626
Query: 2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2176
T+ +LK SK E + M + L ++ L E +K+ D +L++
Sbjct: 1627 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1682
Query: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2236
+ K ++ K E++ L D V++T + E V Q+ E+ + ++N
Sbjct: 1683 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1735
Query: 2237 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2296
L ++ S V + R H +V + F E D +
Sbjct: 1736 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1778
Query: 2297 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2356
E+ T D +TQ ++ + KV+ AQ+E K +
Sbjct: 1779 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1815
Query: 2357 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2410
Q+ I +TQ L + E E L + M L +E A S+ K SL
Sbjct: 1816 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1875
Query: 2411 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470
QE LEK F EF+ W ++ + D L KL ++ + V + L
Sbjct: 1876 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1934
Query: 2471 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2518
+T G + ++ +S +Q ++ A + F++ +C L+
Sbjct: 1935 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1994
Query: 2519 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2577
D + +ED L + E + ++L E P+ + ++ + + G++ +
Sbjct: 1995 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2053
Query: 2578 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
+ +++KL + + LL G + ++ +++L + E+ Q+ L
Sbjct: 2054 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2113
Query: 2634 EALEEALQSMWFWVKAIQDRLA----CAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN 2689
++++ L M W+ ++ L ++ +D + K + QDI + +N
Sbjct: 2114 LSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI----AGRQSSIN 2169
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
K ++ + +++ +Q +++ L +++ + +E + ++ +
Sbjct: 2170 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2229
Query: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--- 2806
+L+ ++E+ Q + P + E + S E + H LH L+ +
Sbjct: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL 2289
Query: 2807 ------LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD------ 2854
+ EKT + S K E+ + + +T +E++ + +VK ++
Sbjct: 2290 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2349
Query: 2855 -------AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRV 2907
+ L K+ +WS + + + LI + A ++ V
Sbjct: 2350 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2409
Query: 2908 ESLAPEVKQNTTASGCELMHTE--MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965
+S + TA+ E + +++ D L++ ++ E
Sbjct: 2410 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA-------EL 2462
Query: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGK------NTDEEIVECWHKGQEILDA-LQK 3018
+ ++++L++A E+ SA+++ W Q++ K TD E V+ + + +A L++
Sbjct: 2463 NTKLSKLQKAQEESSAMMQ-WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2521
Query: 3019 AEPRTEDLKSQLNELCRFSRDL------STYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
+ ++LK +L EL + D ++ +E N L + + + L
Sbjct: 2522 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2581
Query: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132
Q F+ +QWLV ++ + + + + ++T Q++Q L E + + +
Sbjct: 2582 TQ-FQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2640
Query: 3133 SKGE-LLSTLLTKEKAKGI-QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAE 3190
+ G+ +LS +GI + ++ A + W + L + ++ ++ ++
Sbjct: 2641 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2700
Query: 3191 PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEG 3250
+ D LS + + S A ++ + Q + +EI + Q+ + AQ L E
Sbjct: 2701 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI----KVAQALCED 2756
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKE-------KVSRLDRIVAEHNQFSLGIKELQDWM 3303
+A + ++LS Q + K+ V L A +QF ++ Q W+
Sbjct: 2757 LSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL 2816
Query: 3304 TDAIHMLDSYCHPTSDK-SVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362
D + HP S K VL+S + + + + GE++L T
Sbjct: 2817 -DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE 2875
Query: 3363 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE- 3421
+Q QL ++K W + +++L+ +L K Y++ V W+D + NL E
Sbjct: 2876 KAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI 2935
Query: 3422 --------SERQHAELR----DKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
E A+L+ + G +LLN +SLL E+ +T+
Sbjct: 2936 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA---NSLLSVCEIDKEVVTD---- 2988
Query: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529
E + L ++ + E+ E + + +E+Q K + L +E+LD + L
Sbjct: 2989 --ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3046
Query: 3530 GDAHTHE-TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRAL--ESLRQDW 3586
A++++ T+ Q+ + + Q L L V S D L E++ Q+
Sbjct: 3047 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3106
Query: 3587 QAYQHRLSE------TRTQ-FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDE 3639
++ E T+ Q + N +R M +F + D+ L + E + E
Sbjct: 3107 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3166
Query: 3640 VEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL------- 3692
+ + E L S+ N+ C+ T L+ + ++ L ++ L
Sbjct: 3167 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3226
Query: 3693 -EESESSLSSYSDWYGSTHKNFKNVATKIDK---------VDTVMMGKKLKTLEVLLKD- 3741
E+ E ++ ++Y S K F + K ++ ++T + ++L +V K+
Sbjct: 3227 EEQVEGTIKRLEEFY-SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3285
Query: 3742 MEKGHSLLKSAREKGERAVKYLEEGEAER-LRKEIHDHMEQLKELTSTVRKEHMTLEKGL 3800
+E + G+ ++ + + + L ++ D + K L V + L++ L
Sbjct: 3286 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3345
Query: 3801 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3860
F D ++L W+ + +E++ + P E KAQ+ + K LQ+ + + +V+
Sbjct: 3346 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3405
Query: 3861 VREKGEALL---ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
++ +GE + E V + ++ L S ++ L + KA N Q++G
Sbjct: 3406 IKREGEKIATTAEPADKVKILKQLSLLDSRWEAL--LNKA----------ETRNRQLEGI 3453
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977
+++ Q L + + T + C LE ++ +H + +D +
Sbjct: 3454 SVVAQQFHETLEPLNEWLT-----TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3508
Query: 3978 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037
L +S +++K + +R D++ S D S
Sbjct: 3509 NKHLHQA-----------VSIGQSLKVLS--------SREDKDMVQSKLDFSQVWYIEIQ 3549
Query: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELEL 4094
+ + ++Q L A+ + E+ + +E+ L D + + ++ SEL
Sbjct: 3550 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR- 3608
Query: 4095 NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS 4154
V Q ++K QA +N + E + + T E ++ + ++ D+ + S
Sbjct: 3609 ------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3661
Query: 4155 NNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4209
++ E+ LQ R H C + +V +E + E L +A + + LKK
Sbjct: 3662 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3721
Query: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VS 4268
A + K ++ L + ++E + +E +++ + +R+ + D I +K++ +
Sbjct: 3722 EA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3778
Query: 4269 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328
L Q+ EL W E + + D L E+ +
Sbjct: 3779 AAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKD 3837
Query: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388
++ L+K ++M E+Q ++K L + + + + +R L +A S QF
Sbjct: 3838 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3897
Query: 4389 MAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4448
+ + + + I L + + +Q + + + + ++ + + G +
Sbjct: 3898 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3957
Query: 4449 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4508
L+ E++ E + K ++Y + + R L++ + F + D+ L+
Sbjct: 3958 LL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4016
Query: 4509 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHS 4568
+ ++ E ++ Q+++ +N+ + + L TL++ G+ ++ D
Sbjct: 4017 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4076
Query: 4569 Y----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQF 4623
+ +KL+ + + I L +++ K+ + + LA K + + L ++ + + F
Sbjct: 4077 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DF 4134
Query: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP---D 4679
+R + P + Q+ I +E+ GL E +D +N E + G+P +P
Sbjct: 4135 IRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4193
Query: 4680 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE---- 4735
+ L + + L + + R+ LE+ A +++ Q + + + + ++
Sbjct: 4194 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD 4253
Query: 4736 -ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGE 4793
ET+ + E+LK + S A Q I ++R+ E L L + E +H +Q E
Sbjct: 4254 LETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLME 4307
Query: 4794 LKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4849
LKL+ ++ E + + ++ ++ FQ + L WL + LS + + + I
Sbjct: 4308 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
Query: 4850 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4909
+ E+ K + Q +V + + A++ + + +++L++ L L++ ++ E
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME- 4966
R+ L Q + ++ + WL D + L LA L E+A+E L HME
Sbjct: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHMEV 4486
Query: 4967 ---FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5023
F + E+ + S +++ ++A + + +++Q + +L+ + + + +
Sbjct: 4487 CAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERKT 4542
Query: 5024 LLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVSV 5080
L+ ++ + ++ I + E+ L S SL+ + + + EHK +
Sbjct: 4543 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFANE 4598
Query: 5081 VNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140
VNS E+I+ L++ + L+ + + +V RW ++ ++ + L+DA
Sbjct: 4599 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4658
Query: 5141 EWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGML 5200
F+ K E +++ + L ++ T L H F L + S
Sbjct: 4659 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4718
Query: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV-- 5257
+ S+ E+ L + + D +++K T GK V+++ K E +
Sbjct: 4719 NRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLF 4769
Query: 5258 ----ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQKE 5312
+ ++ W+ Y P + D + ++ +++ NH+ +
Sbjct: 4770 SGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AFQ 4815
Query: 5313 KYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTT 5372
K LG T S+Q AL R+ I+ + K QELS + + + +
Sbjct: 4816 KELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSIS 4866
Query: 5373 ILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGK 5432
T+L+A EE L+E A ++ L +G L +
Sbjct: 4867 KQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRT 4914
Query: 5433 LTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWNS 5487
L + H++ +++ E + ++LN+A + + + + + I WI + +AW
Sbjct: 4915 LIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAK 4974
Query: 5488 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQ 5547
Q R L + ++ LEA+ LQ+ + T+K + + + E EE++
Sbjct: 4975 QHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVKA 5025
Query: 5548 MI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
+I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5026 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5076
Score = 298 bits (764), Expect = 1e-79
Identities = 722/4020 (17%), Positives = 1553/4020 (38%), Gaps = 449/4020 (11%)
Query: 4877 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1148 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1207
Query: 4928 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 4972
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1208 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1267
Query: 4973 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5026
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1268 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1327
Query: 5027 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1328 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1384
Query: 5085 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5142
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1385 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1444
Query: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5202
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1445 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1497
Query: 5203 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5256
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557
Query: 5257 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5316
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1605
Query: 5317 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5359
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1606 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1665
Query: 5360 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5414
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1666 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1725
Query: 5415 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5468
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1726 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1784
Query: 5469 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5525
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1785 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1841
Query: 5526 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1842 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1901
Query: 5586 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5634
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1902 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1961
Query: 5635 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5690
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1962 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 2010
Query: 5691 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5748
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 2011 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2058
Query: 5749 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5796
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2059 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2118
Query: 5797 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5848
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2119 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2176
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2177 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2236
Query: 5909 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 5968
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2237 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2295
Query: 5969 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6018
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2296 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2355
Query: 6019 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2356 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2413
Query: 6079 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6135
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2414 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2473
Query: 6136 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6184
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2533
Query: 6185 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6228
E+L E + D E P D QEL + E+SS
Sbjct: 2534 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2587
Query: 6229 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6266
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2588 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2647
Query: 6267 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6323
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2648 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2706
Query: 6324 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6383
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2707 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2762
Query: 6384 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2763 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2820
Query: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6487
P++ +++ ++ K+F + +K E ++
Sbjct: 2821 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2880
Query: 6488 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6546
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2881 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
Query: 6547 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6602
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3000
Query: 6603 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6659
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 3001 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3056
Query: 6660 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6715
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3057 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116
Query: 6716 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6775
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3172
Query: 6776 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6833
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3173 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3232
Query: 6834 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6889
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3233 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3289
Query: 6890 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 6949
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3290 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3344
Query: 6950 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7008
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
Query: 7009 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7068
I++ G + + ++ L L W L + L+ +
Sbjct: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3464
Query: 7069 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7128
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3523
Query: 7129 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7174
+ + + + + W EI E+ S LLQ +
Sbjct: 3524 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3580
Query: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7229
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3581 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3640
Query: 7230 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7283
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3641 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3699
Query: 7284 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7343
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3700 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3734
Query: 7344 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7397
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3735 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3794
Query: 7398 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7455
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3795 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3854
Query: 7456 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3855 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3913
Query: 7516 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7573
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3914 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3964
Query: 7574 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7630
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3965 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4023
Query: 7631 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7679
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 4024 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4082
Query: 7680 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7739
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4083 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4142
Query: 7740 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4143 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4202
Query: 7796 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7853
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4203 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4259
Query: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4260 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4316
Query: 7914 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4317 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4376
Query: 7974 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8033
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4377 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4436
Query: 8034 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8093
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4437 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4495
Query: 8094 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8150
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4496 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4536
Query: 8151 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8209
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4537 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4584
Query: 8210 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 8269
+ + D + ++ S + + D+ G K F + V L ++ + K+
Sbjct: 4585 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4643
Query: 8270 ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELD------TSYK 8323
+ ++ A + +Q +A ++++E + S+ + D +K
Sbjct: 4644 QRLVERGRSLDDA-RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4702
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ +
Sbjct: 4703 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVER 4759
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8443
+ ++++ L QF L ++ WL E +L + Q + DI + I K QK
Sbjct: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKE 4817
Query: 8444 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8503
+ R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4818 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877
Query: 8504 CQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4878 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAEL 4933
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4934 NKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4993
Score = 295 bits (754), Expect = 2e-78
Identities = 767/4203 (18%), Positives = 1632/4203 (38%), Gaps = 605/4203 (14%)
Query: 4269 VTNLE-ELNVVQSRFQELMEWAEEQQPN-------IAEALKQSPPPDMAQNLLMDHLAIC 4320
+T LE E+NV + +QEL++ AE ++ I+E + ++ L+ +
Sbjct: 1074 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1133
Query: 4321 SELEAKQMLL------KSLIKDADRVMADLGLN----ERQVIQKALSDA----QSHVNC- 4365
E + + + L K+ +R+ DLG E Q A S + +S +N
Sbjct: 1134 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1193
Query: 4366 ---LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422
++ + Y++K L L A + ++ +E K+ E + +++ +
Sbjct: 1194 LQNMNQVYSMSSTYIDK-LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1252
Query: 4423 KTCKSAQASLK-------TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV--YD 4473
T K ++ + ++E+ A E+ K E++ K + Q V +
Sbjct: 1253 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1312
Query: 4474 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFP-EINLMNESSELHTQLA 4532
+V + +RL++LE S K++++ + W++Q + + N S L TQL
Sbjct: 1313 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1372
Query: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVA--LAKD 4590
+ + ++ + ++ + Q+ + ++ + + ++ + +Q + + +
Sbjct: 1373 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1432
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILD 4650
+QE + R Y +L+ L TQ + R+ EE SL++ + ++
Sbjct: 1433 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE--------EEEKSLEEEKKEHVE 1484
Query: 4651 EVAGLGEAVDELNQKKEGFRSTGQP----------------WQPDKMLHLVTLY---HRL 4691
+ L + V +++ + G+P Q + L + L+ H
Sbjct: 1485 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1544
Query: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
K E+R L + + + + + + +QL+ + EE + AE + + L
Sbjct: 1545 KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQ 1604
Query: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
G R+ H E + +K + + + Q +++ A+ E V E+
Sbjct: 1605 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF 1664
Query: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL-RIM 4870
+ ++ + ++ ++L ++ L + + + ++ + E+ + L +++
Sbjct: 1665 LKENGEKLSQEDKAL---------------IEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1709
Query: 4871 NALSHKEKEKFTKAKELISAD--LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYY 4928
+E EK K+L + +E+ L LS +D D + A + ++ Q ++
Sbjct: 1710 TTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHK----QVIEQNGTHF 1765
Query: 4929 QVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKS--------HMEFFSTEDQFHSNL 4978
Q + E+ + L +D V + +ENL H + S
Sbjct: 1766 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1825
Query: 4979 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5038
+ L+ + P KE L++ + L++ + +S ++ L + +
Sbjct: 1826 QSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1885
Query: 5039 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5098
E + +E++L + KL K SF E +++ + +
Sbjct: 1886 YTEFEHWLQQSEQELENLEA-GADDINGLMTKLKRQK-------SFSEDVISHKGDLRYI 1937
Query: 5099 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5158
+GN +A S S + T A ++ ++ L+ A D + +K +
Sbjct: 1938 TISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1995
Query: 5159 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5218
L DK Y D L Q+
Sbjct: 1996 LVDKYQ----------------HYEDASCGLLAGLQAC---------------------- 2017
Query: 5219 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5278
E TA + ++ E + + K ++++L++ + ++ QI+S + V++ K+
Sbjct: 2018 ------EATASK----HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK---TA 2064
Query: 5279 TIEIDAQ------LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LA 5330
+ +DA+ ++Q L + +++ K E+ EK L L LS+Q L
Sbjct: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK---LQITLTRSLSVQDGLD 2121
Query: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
E+ L ++ +KE Q S L I K N++
Sbjct: 2122 EM---LDWMGNVESSLKEQGQVPLNSTALQDIISK-----------------NIM----- 2156
Query: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNG-QLGKPLAKKIGKLTELHQQTIRQAENRLS 5449
L +++ G S + ++ V+KF+E L K+ L+ + + + L+
Sbjct: 2157 ---LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2213
Query: 5450 KLNQAASHLEEYNEMLELILKWIE-KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI 5508
K+ + + +E + + E + ++E K + L + ++L QY+ T E E
Sbjct: 2214 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL-SQYMQEST--SEFLEH 2270
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565
LE + L+ ++S + ++ L ++ +E+ IK + + + + +
Sbjct: 2271 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2330
Query: 5566 FEAELKKLQAALEQA--QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ---- 5619
F+ +K L++ +++ + + P G L + L + L + P++Q V
Sbjct: 2331 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2390
Query: 5620 -LCQ--SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676
LC SA+ P +A++ A L + A+ + + + +
Sbjct: 2391 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG--LTSIKKDMTDISHGY 2448
Query: 5677 KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG----YQEQIASLNS--- 5729
+ L L++ E+ K S +Q+ Q + S + QK+ +Q+ A ++
Sbjct: 2449 EDLGLLLKDKIAELNTK---LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2505
Query: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA--GRCHTL-- 5785
K ++ K+ A + V +V+ L + +L E TP A M+T + L
Sbjct: 2506 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2565
Query: 5786 LSPVTEESGEEGTNSE--------------ISSPPACRSPSPVANTDASVNQDIAYYQAL 5831
L+ ++ EE +N+ + P++ +N Q L
Sbjct: 2566 LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2625
Query: 5832 SAERLQTDAAKIHPSTSASQEFYE-PGLEPSATA----KLGDLQRSWETLKNVISEKQRT 5886
E T + T+A Q PG +PS +L + + W++L +S++
Sbjct: 2626 LQE-FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2684
Query: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQ 5943
+ +A+ + +YQ L+S+S K+ ++ KLS S P++ Q+ Q + EI +
Sbjct: 2685 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2744
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
+I Q +L E+L + E +L+ Q L + + + KA Q L+
Sbjct: 2745 KQIKVAQ-ALCEDLSALVKEEYLKAELSRQ--LEGILKSFKDVEQKAENHVQHLQSACAS 2801
Query: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDM-----------EAQL 6052
+ Q+ + Q + E + A LD S K+ D E +
Sbjct: 2802 SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2861
Query: 6053 MDCQNMLVEIEQKVVALSELSVH---------------NENLL---LEGKAHTKDEAEQL 6094
+ +N+L++ + A +L ++ EN L LE K++ E L
Sbjct: 2862 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2921
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + + +L E++ L E E S L + Q Q +
Sbjct: 2922 WPWIDKCQNNLEEIKFCL---------DPAEGENSIAKLKSLQKEMDQHF---GMVELLN 2969
Query: 6155 QRQSSLQQQKELEQELA--EQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG 6212
+SL E+++E+ E KSL++ V E++ + E ++ +S+E
Sbjct: 2970 NTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-- 3027
Query: 6213 MEGEKSSAEDQMRMKWESLHQEFS--------TKQKLLQNVLEQ-------EQEQVLYSR 6257
+ + A++Q+ + Q +S T+QK LQ + Q Q+ V+ +
Sbjct: 3028 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEAS 3087
Query: 6258 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVS 6317
++ S V L + + Q+ S ++ +D +F E Q G H + + + S
Sbjct: 3088 DSKGTSDV-LLQVETIAQEHSTLSQQVDE-KCSFLETKLQGIG------HFQNTIREMFS 3139
Query: 6318 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL-----FSQA 6372
+ + D+++ + A + + ET +E + +K++ M N N A
Sbjct: 3140 QFAEFDDELD-----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3194
Query: 6373 FPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK---VLFTSL 6429
E + I+ L L + + L R Q++ ++++ F + LK +L
Sbjct: 3195 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3254
Query: 6430 ADNKYI---------ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
+++ + + N+F+ E+IE +Q + + G+I+ + Q
Sbjct: 3255 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3314
Query: 6481 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 6540
+ +L + + L + R + L + L +++ AL+ L + E++
Sbjct: 3315 GLE---HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM-VDTEELVA 3370
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 6600
+QK + + ++ + + K + L+ E + R+ A E +++ Q S
Sbjct: 3371 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430
Query: 6601 -------AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR 6653
A+L +A R +LE I E + L+ L +E + + + +
Sbjct: 3431 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3490
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTN 6710
L ++I ++ L+ + + L+Q + G+ L + S D ++S+L+ ++
Sbjct: 3491 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550
Query: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE-----------FWTQQSVTVPQ 6759
K L+ L + + + +L++WL D+L W QQS
Sbjct: 3551 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS----- 3605
Query: 6760 ELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWT 6818
EL ++++ + L + VD L G +LL+ D ++ +L I +++
Sbjct: 3606 ELRVLQEDI---LLRKQNVD-------QALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3655
Query: 6819 D---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 6875
D L T++ E+ QL +L S H E+ +W+ +E + E +
Sbjct: 3656 DITKLSTDVAKTLEQALQLAR-RLHSTH--EELCTWLDKVEVELLSYETQV--------- 3703
Query: 6876 HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD------KTDFAEQLGAMN 6929
L+ + + + K+L + N L S +V S + + + + N
Sbjct: 3704 ---LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3760
Query: 6930 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK-------QQHRIGD 6982
+ ++++ +T+K++ ++ + +++ +W EK+L +Q +
Sbjct: 3761 ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3820
Query: 6983 QASVQNA-----LKDCQDLEDLIK---------------AKEKEVEKIEQNGLALIQNKK 7022
Q VQ L+ ++DL+K + +K+++K+ +N + Q
Sbjct: 3821 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3880
Query: 7023 EDVSSI--VMSTLRELGQTWANLDHMVGQLKILL--------------------KSVLDQ 7060
E + S + + +T+ L + + + ++ + + +
Sbjct: 3881 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3940
Query: 7061 WSSHKVAFDKINSYLMEARYSLSRFRLLTG---SLEAVQVQVDNL-QNLQDDLEKQERSL 7116
+ HK DK+N + L G S++ V D L +++D++K+ +L
Sbjct: 3941 IAEHKPHIDKMN------KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVAL 3994
Query: 7117 QKFGSITNQLLKECHPPVTETLTNTLKEVNM--RWNNLLEEIAEQLQSSKAL---LQLWQ 7171
+ S + Q + + E+L ++ + + +E+I EQ+ +K + ++ Q
Sbjct: 3995 DEAISQSTQFHDKI-DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQ 4053
Query: 7172 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATW-------------IQDCNDL 7218
+ KQ + + T++ + A +D D V W + D +L
Sbjct: 4054 PLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4113
Query: 7219 --------LKGLGTVKDSLFFLHELGEQ------LKQQVDASAASAIQSDQL-------- 7256
+ + T+KD+ F+ +L + +KQQ +A+ + D L
Sbjct: 4114 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4173
Query: 7257 SLSQHLCA-----------------------LEQALCKQQTSLQAGVLDYETFAKSLEAL 7293
+L L A L +A + L+ + + L+A+
Sbjct: 4174 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4233
Query: 7294 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYRLP 7350
W+ A L P +DL T+++++EELK + +++RLN EL +
Sbjct: 4234 FDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4292
Query: 7351 LNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7406
+ + +Q+ L W + + R KL+ LL F + + +L TE
Sbjct: 4293 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4352
Query: 7407 KLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 7464
L+ + + G+ + + + H + Q ++ + Q + ++ G L+E ++
Sbjct: 4353 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4412
Query: 7465 KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS--YLPMSGLGSV 7522
KL +L+ +WQ V+ + +QR+ +D +RQ + + E L++WL + L LG +
Sbjct: 4413 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4472
Query: 7523 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7582
P ++ + EV F ++ +Y ++ G+Q+L AE + ++ ++EK
Sbjct: 4473 PETAKEQLNVHMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEK 4529
Query: 7583 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS-QSLPDHHEELHAEQM 7641
W+S +L E+K KL L + + D + L ++ L+ S P + Q+
Sbjct: 4530 WESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQI 4589
Query: 7642 -RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7700
K N V S + + +L L + D+ ++ + +Q +WE++ +L R
Sbjct: 4590 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4649
Query: 7701 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEE 7754
+ + + F E +L EWL ES+ S + ++ I +K+K K++Q+
Sbjct: 4650 GRSLDDARKRAKQFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4707
Query: 7755 IAIAQENKIQLQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+ + G L K S +++ L ++ D+W + R KL+E L
Sbjct: 4708 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4767
Query: 7814 VAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ Q + +L WL +E +LA +P+ D + + ++ + Q+++ K ++
Sbjct: 4768 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD---IDLVMNLIDNHKAFQKELGKRTSS 4824
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
V ++ L+ + D+ +Q + L RW +CA+S+ ++ ++E R +
Sbjct: 4825 VQALKRSARELI---EGSRDDSSWVKVQM--QELSTRWETVCALSISKQTRLEAALRQAE 4879
Query: 7932 KFLDDYSRFEDWLKSSERTAAF----PSSSGVIYTVA---KEELKKFEAFQRQVHECLTQ 7984
+F +WL +E+T F P + T+ KE +KK E + ++++ T
Sbjct: 4880 EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4939
Query: 7985 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL-------QKRVTSILRRLKHFIG 8037
+ + DS ++K + R++ + Q+R+ S L L I
Sbjct: 4940 GDTV-------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL---IA 4989
Query: 8038 QREEFETARDSILVWLTEMDLQLTN-----IEHFSECDVQAKIKQLKAFQQEISLNHNKI 8092
++E E ++L WL + LT+ I E +V+A I + + F +E++ +
Sbjct: 4990 KQELLE----ALLAWLQWAETTLTDKDKEVIPQEIE-EVKALIAEHQTFMEEMTRKQPDV 5044
Query: 8093 EQI 8095
+++
Sbjct: 5045 DKV 5047
Score = 286 bits (731), Expect = 8e-76
Identities = 864/4710 (18%), Positives = 1776/4710 (37%), Gaps = 672/4710 (14%)
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA-KEFSDKCK 3811
+E G+ + LE +A LR E+ + +E L+++ + V+++ + E L LA K
Sbjct: 400 KEWGKLIIAMLEREKA--LRPEV-ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK 456
Query: 3812 ALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----KSLQQTVLSHEPSVKSVREKGE 3866
L + ++ +A+++ Y L+Q V+ + + + +
Sbjct: 457 RLESGVQ----------------FQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQAD 500
Query: 3867 ALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH 3926
L++ V L+D+I L+++ + S G+ + E + +I
Sbjct: 501 QLVQRV--AKLRDEIMALRNECSSVYSKGRILTTE-------------QTKLMISGITQS 545
Query: 3927 LQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 3986
L + Q +H L T+ M L + ++ T + S + P
Sbjct: 546 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 605
Query: 3987 DLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQT 4046
+ +P + + Q++ +K++ D TE+
Sbjct: 606 NFSSGVEPNSLQTLKLMQIR-----------------------KPLLKSSLLDQNLTEEE 642
Query: 4047 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH---SELELNIAQNMVSQ 4103
I K VQ +++ ++E L + L+N K H E E ++ + +S+
Sbjct: 643 INMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 702
Query: 4104 VK----------DFVKKLQSKQASV---------------NTIIEKVNKL---TKKEE-- 4133
++ + + +L+S+ A + N + N+L +KEE
Sbjct: 703 IQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 762
Query: 4134 -----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY--------HDCMNVVEV 4180
S + I D +L R+ + Q+EE+++ ++ H +E
Sbjct: 763 VAYDWSERNTNIARKKDYHAELMRELD----QKEENIKSVQEIAEQLLLENHPARLTIEA 818
Query: 4181 FLEKFTTEWDNLAR-------------------SDAESTAVHLEALKKLALALQ-----E 4216
+ T+W + + +DA+ +L LK A+Q +
Sbjct: 819 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCD 875
Query: 4217 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI----------- 4265
R +I L+D Q+ +E +KE + + S + + + +I+ K
Sbjct: 876 RSSSIHKLEDLVQESME-----EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 930
Query: 4266 ---------QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQS-----PPP----- 4306
Q+ +T ++ V + +W + P EA+ S PPP
Sbjct: 931 PIKAICDYRQIEITIYKDDECVLANNSHRAKW-KVISPTGNEAMVPSVCFTVPPPNKEAV 989
Query: 4307 DMAQNLLMDHLAICSELEAKQMLLKS------LIKDADRVMADLGLNERQVIQKALSDAQ 4360
D+A + + + + + +KS LI + DR+ A + + ++
Sbjct: 990 DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPG------ 1043
Query: 4361 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4420
H LS+L + +L S+++Q VF + Q + K
Sbjct: 1044 EHQQVLSNLQSRFEDFLED--SQESQ----VFSGSDITQ------------------LEK 1079
Query: 4421 QVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCS 4480
+V CK + YQ EL+K +E+ E + ++Y S ++
Sbjct: 1080 EVNVCK------QYYQ-----------ELLKSAEREEQEE------SVYNLYISEVRNIR 1116
Query: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540
RL+ E L+ + + D L ++ + L E L L N E+
Sbjct: 1117 LRLENCEDRLIRQIRTPLERDD----LHESVFRITEQEKLKKELERLKDDLGTITNKCEE 1172
Query: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK---DKFYKVQE 4597
Q + +P+L +LN + + N + +++ DK V
Sbjct: 1173 --------FFSQAAASSSVPTLRS--------ELNVVLQNMNQVYSMSSTYIDKLKTVNL 1216
Query: 4598 AILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGE 4657
+ + +L++L L E EA + + E +S R+ +DE +
Sbjct: 1217 VLKNTQAAEALVKLYETKLCEEEAVIADKNNI------ENLISTLKQWRSEVDEKRQVFH 1270
Query: 4658 AVDELNQKKEGF----------RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707
A+++ QK + R W +K LV + + Q + R+ LE
Sbjct: 1271 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1330
Query: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767
+ + + L+ ++ V+ Q K+ +E P K +LA L +++ + +
Sbjct: 1331 SLKYYRDTYHPLDDWIQQVETTQRKI-QENQPENSK-----TLATQLNQQKMLVSEIEMK 1384
Query: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4827
+ +K Q + + +L T V + V+ Q+ +
Sbjct: 1385 QSKMDE------CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1438
Query: 4828 WLRRVKAELSGPVYLDL--------NLQDIQEEIRKIQIHQEE-VQSSLRIMNALSH--- 4875
++ + V L +L+ ++EE + ++ ++E V+ + + +S+
Sbjct: 1439 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
Query: 4876 --KEKEKFTK---AKELISADLEHSLAELSELDGDIQEALRTRQATLT--------EIYS 4922
K+ EK K +K+ IS++ E+S + EAL+T Q L E +
Sbjct: 1499 TLKDAEKAGKPPFSKQKISSE------EISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1552
Query: 4923 QCQRYYQVFQAANDWL-EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL--E 4979
+ ++ + Q + + L ++ + LQ + DV+ E+ + + + + Q +L +
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
Query: 4980 ELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR 5039
+ L+ + + G +L++ + + + + +D L ++ K
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKK----YQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1668
Query: 5040 EEVIELMNDT--EKKLSEFSLLKTSSSHEAEEKLSE-HKALVSVVNSFHEKIVA---LEE 5093
E + + E+KL+E + + +AE+ E K + + + EK+ A LEE
Sbjct: 1669 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1728
Query: 5094 KASQLEK-------TGNDASKATLSRSMT-----TVWQRWTRLRAVAQDQE---KILEDA 5138
+++E D+ +A T +Q A+ ++ E +LE
Sbjct: 1729 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1788
Query: 5139 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5198
VD +V E ++Q K+ KA+ ++ H ++ QSA
Sbjct: 1789 VD------GQVGTTQENLNQQYQKV---------KAQHEKIISQHQAVIIAT---QSAQV 1830
Query: 5199 MLRQQTLSMLQDGAAPTPGEEPPL---MQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5255
+L +Q G +P E+ L M+E+ + L EK +++EL E
Sbjct: 1831 LLEKQ-------GQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---E 1880
Query: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL 5315
+ + W+Q++++ L N ++A +++ L+T+ + E + + + L
Sbjct: 1881 KFDADYTEFEHWLQQSEQELEN----LEAGADDINGLMTKLKRQKSFSEDVISHKGD--L 1934
Query: 5316 GLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILT 5375
TI + ++ E A RD +V+ S AT +E+ R++ ++ +
Sbjct: 1935 RYITISGN----RVLEAAKSCSKRDG-----GKVDTS-ATHREVQRKLDHATDRFRSLYS 1984
Query: 5376 KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435
K +N+ + + G + L +A K L + + ++ + T+
Sbjct: 1985 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2044
Query: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495
Q I + + KL + A L + L I+K G S S + E+
Sbjct: 2045 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS-VNERN 2103
Query: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5555
Q L S + L+ M L ++ +V + K QV + L+ +I +
Sbjct: 2104 EKLQITLTRSLSVQDGLDEM---LDWMGNVESSLKEQGQVP---LNSTALQDIISKNIML 2157
Query: 5556 LQDAAKDMKKFEAELKKLQAALEQAQ-ATLTSPEVGRLSLKEQLSHRQH----LLSEMES 5610
QD A A +K++ +E +T +S + L + S H L++ME
Sbjct: 2158 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2217
Query: 5611 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5670
LK KV+ + + E + L AL + + T + Q MQ + ++
Sbjct: 2218 LKTKVELFE------NLSEKLQTFLETKTQALT-EVDVPGKDVTELSQ--YMQESTSEFL 2268
Query: 5671 QYEQEMKHLQQLIE--GAHREIEDKPVATSNIQELQAQISRHE----ELAQKIKGYQEQI 5724
++++ ++ L L++ +H DK + L + E E + + QEQ+
Sbjct: 2269 EHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2328
Query: 5725 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 5784
+ K L K T + + + + G EDL L T + T
Sbjct: 2329 DAFQVLVKSLKSWIKETTKKVPIVQP---SFGAEDLGKSLEDTKKLQEKWSLKTP----- 2380
Query: 5785 LLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIH 5844
++ NS IS + + A A+V A L+ E T+
Sbjct: 2381 --------EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA---VLNGEGTATN----- 2424
Query: 5845 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5904
++EF+ S + D+ +E L ++ +K L L + QK Q+ ++
Sbjct: 2425 -----TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2479
Query: 5905 ST---KMEAIELKLSESPEPG--RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
KM K ++P P + ++Q+ ++++ E+ +++ EL+ L E L+
Sbjct: 2480 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE-LLE 2538
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRC 6019
E+ D E + LT + + + ++Q LEE N+ + Q E L++
Sbjct: 2539 EN--PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ--- 2593
Query: 6020 EADELDSWLLSTKATLDTALSPPK-EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
WL+ K + + L P +P + Q Q +L E + +L+ +
Sbjct: 2594 -------WLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2645
Query: 6079 LLLEG------KAHTKDEAEQLAGKLRRLKGSLLEL-----QRALHDKQLNMQGTAQEKE 6127
+L + K++ + K L G L + Q + Q + +
Sbjct: 2646 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2705
Query: 6128 ESDVDLTATQSPGVQ---EWLAQARTTWTQQRQSSLQQQKELE--QELAEQKSLLRSVAS 6182
SD+D + S V + + Q T + +Q Q++K+++ Q L E S L
Sbjct: 2706 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2765
Query: 6183 RGEEILIQ-HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR---MKWESLHQE---- 6234
E+ Q ++ D +K + Q L S QM W +E
Sbjct: 2766 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2825
Query: 6235 ---FSTKQKLLQNVLEQEQ-------------EQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S K +L+++++ + E+ + N LL K + Q +
Sbjct: 2826 SHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2885
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLF-VATALL 6337
T+ D N+ +E ++ ++S+ K + V W+D + L + L
Sbjct: 2886 IKTNW-DTFNKQVKERENKL----KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2940
Query: 6338 PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL 6397
P E E + + L K++ + ++ N + +++V+ D L+ ++ ++
Sbjct: 2941 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3000
Query: 6398 DSVVNQRCHQMKERLQQILNFQNDLKV-----------------LFTSLADNKYIILQKL 6440
++ + ++ Q+ FQ K L + NKY+ + +
Sbjct: 3001 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3060
Query: 6441 ANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 6499
Q + Q++ ++ A+D + E + K D L + QE S L DE
Sbjct: 3061 QQKSLQALKHQVDLAKRLAQDLVVEAS----DSKGTSDVLLQVETIAQEHSTLSQQVDEK 3116
Query: 6500 MMIIGSRRSGL----NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL 6555
+ ++ G+ N + SQ+ +L + G+ D + + KE I+
Sbjct: 3117 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-----DAETLQKQKETIKAF 3171
Query: 6556 LDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR 6609
L K + ++ M+ TE ++ E L Q + +L RA R
Sbjct: 3172 LKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA-----LSKQCNKLLDRAQAR 3226
Query: 6610 GVELEYIL----ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665
++E + E +S L E L + E ES P VG+ E ++ ++ ++Q K
Sbjct: 3227 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGP-VGMETETINQQLNMFKVFQ--K 3283
Query: 6666 SSLNEYQPKLYQVLDDGKRLLISI----SCSDLESQLNQLGECWLSNTNKMSKELHRLET 6721
+ Q K V G+ L+ S S LE L+ + W + K+++ +L+
Sbjct: 3284 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343
Query: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
L H R+Q L+ W+ ++ + S E ++V+ + + +D +
Sbjct: 3344 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVKAQIQEQKLLQRLLDDR 3399
Query: 6782 SSLKSSVLSTGNQLLRLKK-VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
S + G ++ + D + +LS +DS+W LL +L + +
Sbjct: 3400 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3459
Query: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDI---NCKQLT 6895
+ + W++ +E + E IG +A + E + ++K + DI N
Sbjct: 3460 FHETLEPLNEWLTTIEKRLVNCEP-----IGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514
Query: 6896 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQI-LQGLVTEKIQLLEGLLESWS 6954
+ QS+ +SS++ + K DF++ W I +Q + +LL+ L +
Sbjct: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQV-------WYIEIQEKSHSRSELLQQALCNAK 3567
Query: 6955 EY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013
+ E+ V+ + E +K K + + + + L++ I +++ V++ N
Sbjct: 3568 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3627
Query: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073
GL L++ D I+ L + + ++ + + L+ L +++ +
Sbjct: 3628 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3687
Query: 7074 YLMEARYSLSRF--RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
+L + L + ++L G EA Q Q+ + L+ + + + L +++ LL+
Sbjct: 3688 WLDKVEVELLSYETQVLKGE-EASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLELVP 3745
Query: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
E L + E N R+ + + I ++++ A + Q++ + S + + E +
Sbjct: 3746 WRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL 3805
Query: 7192 NELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAI 7251
L +D ++ ++L+ + D + H++ ++ S +
Sbjct: 3806 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Query: 7252 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 7311
L +C + Q Q+ V F ++ E L W+ E + I+ Q P+
Sbjct: 3866 DK-VLKNYDTICQINSERYLQLERAQSLV---NQFWETYEELWPWLTETQSIIS-QLPAP 3920
Query: 7312 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-PLNDKEIKRMQN----LNRHW 7366
+ + T++++ EE + + P +D++N+ G +L L+ E +Q + +
Sbjct: 3921 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY 3980
Query: 7367 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQR 7424
S I +R L + Q F +K + +E L + ++L IS + + EQ
Sbjct: 3981 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQIS 4040
Query: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRA 7480
++ +M Q + ++ G+ ++ + D+D KL + W+ +
Sbjct: 4041 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4100
Query: 7481 QQRRG----IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ--ARTLFD 7534
++R +++ + W + + ++ + L G+ + QQ A T+ +
Sbjct: 4101 EEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4160
Query: 7535 EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQK 7594
E+ Q + + G +L+ + + ++ + E+ W S + +++
Sbjct: 4161 EID-------GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4213
Query: 7595 KKLAFLLK-------------DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE---ELHA 7638
KL ++ DW G S+ + T + + Q + + + E +
Sbjct: 4214 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4273
Query: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
+Q+ + L + Q LL L D + + + L+ W+ L ++
Sbjct: 4274 QQIEMERLNH----------QAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERII 4320
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN----GDILIEEMIEKLKKDYQEE 7754
R+ ++ L F EL WLT E +S+ GD E IE K +
Sbjct: 4321 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE-IELAKHHVLQN 4379
Query: 7755 IAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+A ++ ++ + + G L ++S +AS ++ KL +N RWQ++L+ R ++L L
Sbjct: 4380 DVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4439
Query: 7814 VAVQQLDKNMSSLRTWLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ + L+ WL E L +KP+ E + +LN E+ E
Sbjct: 4440 RQAKGFHGEIEDLQQWLTDTERHLLASKPL---GGLPETAKEQLNVHMEVCAAFEAKEET 4496
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
S++ + +L C A +I Q NL +W ++ ER+ K+EE L
Sbjct: 4497 YKSLMQKGQQMLARCPKSAET----NIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4552
Query: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
+F + F +WL +E+T S +I ++ + + F +V+ Q+ ++K
Sbjct: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
Query: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
L ++ +K ++ RW+ + +R+ R L + ++F A ++
Sbjct: 4613 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4672
Query: 8052 WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL 8109
WL E + L + +E ++ D ++ ++ Q K FQ+ + H+ + G L EK+
Sbjct: 4673 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4732
Query: 8110 DAAI-IEEELDELRRYCQEVFGR-VERYHK 8137
D + +++ L ELR + G+ VER +K
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNK 4762
Score = 278 bits (712), Expect = 1e-73
Identities = 768/4289 (17%), Positives = 1650/4289 (38%), Gaps = 539/4289 (12%)
Query: 1285 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1344
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1045 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1104
Query: 1345 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1394
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1105 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1161
Query: 1395 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1454
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1162 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1220
Query: 1455 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1514
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1221 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1276
Query: 1515 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1547
Q S F T E +I +L + G+ L+ +
Sbjct: 1277 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1336
Query: 1548 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1604
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1337 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1389
Query: 1605 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664
CQ SA K + A QQ + RR Q++ + ++ +
Sbjct: 1390 ECQKYAEQYSATV-------KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEF 1440
Query: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEVVSQASFYSKL 1723
L ++ +T + + + + D +K +E E + ++ + E V +A K
Sbjct: 1441 MDLRTRYTALVTLM--------TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA----KE 1488
Query: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
LQ S S KD K K P ++I+ + + + +Q E L +
Sbjct: 1489 LQKWVSNISKTLKDAEKAGK-------------PPFSKQKIS-SEEISTKKEQLSEALQT 1534
Query: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
I+LFL+ +H D + E + EL+ L + +L +
Sbjct: 1535 ----IQLFLA------------------KHGDKMTDEE--RNELEKQVKTLQESYNLLFS 1570
Query: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNS 1903
E L LQ +++ + E V ER+Q + L GI L QT
Sbjct: 1571 ESLKQLQ-ESQTSGDVKVEEKIVAERQQ----------EYKEKLQGICDLLTQT------ 1613
Query: 1904 MNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLC 1963
E+ LI Q A + V L SK + E + + +A L
Sbjct: 1614 ----ENRLI------GHQEAFMIGDGTVELKKYQSKQE--------ELQKDMQGSAQALA 1655
Query: 1964 GEVERIQNLL---GTKQSEADALAVLKKAFQDQK---EELLKSIEDIEERTDK---ERLK 2014
V+ +N L G K S+ D A++++ + K E+L E ++ DK +K
Sbjct: 1656 EVVKNTENFLKENGEKLSQEDK-ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 1714
Query: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKD----------KAKQIAQKD-------- 2056
E T +++ QLE+ E+ L WL + K KQ+ +++
Sbjct: 1715 EET-----EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGD 1769
Query: 2057 --VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
A E + N LE D EN L ++YQ +K+ K++ +
Sbjct: 1770 GKSAIGEEDEVNGNLLETDVDGQVGTTQEN---------LNQQYQKVKAQHEKIISQHQA 1820
Query: 2115 VIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLD-NFTSKGKHLLSELKKIHSSDFSL 2173
VI+ + + + + + E K K+ K+L ++ + ++K HS L
Sbjct: 1821 VIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1879
Query: 2174 VKTDMEST-VDKWLDVSEKLEEN-----------MDRLRVSLSIWDDVLSTRDEIE--GW 2219
K D + T + WL SE+ EN M +L+ S +DV+S + ++
Sbjct: 1880 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1939
Query: 2220 SNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETP 2278
S N V + A++ S D + +E + ++ + R L+SK N L K
Sbjct: 1940 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----- 1994
Query: 2279 PDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA 2338
DL+ K +H + + + G L A K +++ K
Sbjct: 1995 --------DLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPIAVDPK--------- 2034
Query: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQENLNSL--CRKYHSAELESLGRAMTGLIKKH 2396
L++ K +Q ++ SQQ + ++ L R + + + ++ ++
Sbjct: 2035 --NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2092
Query: 2397 EAVSQLCSKTQASLQESLEKHFS--ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
E +S+ ++ LQ +L + S + + E +W +++ KE +S L+ +
Sbjct: 2093 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2152
Query: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
+ ++ QS ++A+ ++ + SS+Q ++ + F + +
Sbjct: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212
Query: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----ENLGESKQHIPEKKNEV--HKV 2567
+++ +++ FE+ KL ++ + +++ E Q++ E +E HK
Sbjct: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2272
Query: 2568 EM-FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSC 2626
+ L LL S S + +L + + S+ ++ ++ KE + SC
Sbjct: 2273 HLEVLHSLLKEISSHGLPSDKALVLEKTNN--------LSKKFKEMEDTIKEKKEAVTSC 2324
Query: 2627 QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGE 2683
Q L + L ++L+S W+K ++ + + G++D L K L ++Q+ +K
Sbjct: 2325 QEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAED-LGKSLEDTKKLQEKWSLKTP 2380
Query: 2684 GEVKLN----------MAIGKGEQALRSSNKEGQRVIQTQ--LETLKEVWADIMSSSVHA 2731
K+N A+ +A+ ++ K G V+ + +E WA+ +S+
Sbjct: 2381 EIQKVNNSGISLCNLISAVTTPAKAI-AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2439
Query: 2732 QST-------------------LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ-PQP 2771
T L + +S+ E + + QW++ +++ Q P P
Sbjct: 2440 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2499
Query: 2772 GLKEKF-VLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE---ELKTQ 2827
E ++ +S +E + + + L K EL E+ D ++ E+ ++
Sbjct: 2500 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2559
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
+ ++ + ++ +K+EE + + + WL + + +S D + +
Sbjct: 2560 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2619
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTA-SGCELMHTEMQALRADWKQWEDSVFQ 2946
+++ L L + P+ +Q T A G E +LR K+ +V Q
Sbjct: 2620 QQVQIL----------LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2669
Query: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSALLKTWAQQLTLLEGKNTDEEIV 3003
L + S + ++QA+ Q+ +LL++ + +L+ L+ K + V
Sbjct: 2670 KWDSLTG----------QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2719
Query: 3004 ECWHKG-QEILDALQKAEPRTEDLKSQLNELCRFSRDLST----------YSGKVSGLIK 3052
+ L+ QK + + K Q+ DLS S ++ G++K
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2779
Query: 3053 EYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS 3110
+ + +A Q+ + +F++ RDFQ WL K K I + + +
Sbjct: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2839
Query: 3111 LQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQ 3170
++ ++F H +++GE L + +Q ++ K +W F+ + +
Sbjct: 2840 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2899
Query: 3171 KESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI 3230
+E+ L+ + ++ E + W+ K + + E L D KL+S+ +E+
Sbjct: 2900 RENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCL-DPAEGENSIAKLKSLQKEM 2958
Query: 3231 HCYEPQLNRLKEKAQQLW------------EGQAASKSFRHRVSQLSSQYLALSNLTKEK 3278
+ + L A L E ++ + QL S+ L N+T +K
Sbjct: 2959 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT-QK 3017
Query: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIH-MLDSYCHPTSDKSVLDSRTLKLEALL-SV 3336
+ E + KE D IH L S + ++L ++ L+AL V
Sbjct: 3018 FKEFQEVSKESKRQLQCAKEQLD-----IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV 3072
Query: 3337 KQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396
K + ++V +S +G + Q++++ ++L S LE L
Sbjct: 3073 DLAKRLAQDLVVEASDS-------KGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3125
Query: 3397 KWTSYQDGVR----QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSL 3452
+Q+ +R QF+ + D +++ + K T+ K L + S +
Sbjct: 3126 GIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNA 3185
Query: 3453 LETIEVKGAGMTEHYVTQL-----ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507
+T ++ A TE L +L+ L ++ + +RA+ + E ++ +E+
Sbjct: 3186 NKTCKMMLA--TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3243
Query: 3508 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE------------GQAL 3555
LK F + L + +E + + + T L + Q E GQ L
Sbjct: 3244 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3303
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ S S Q + L+ + W+ ++++ Q + + +
Sbjct: 3304 IQS-------AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3356
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
+ W+ EE +++ + +V + + Q++L + + + + A
Sbjct: 3357 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATT 3416
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
+ +++K L +++ L+ +L + ++ + VA + +TL
Sbjct: 3417 AEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-----------ETL 3464
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEE-GEAERLRKEIHDHMEQLKELTSTVRKEHM 3794
E L + + L + G +A K E+ + + L +I +H + L H
Sbjct: 3465 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL----------HQ 3514
Query: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3854
+ G L S + K + Q ++ ++ ++ E+ EK S+ + LQQ +
Sbjct: 3515 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI------EIQEKSH--SRSELLQQALC-- 3564
Query: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG--------KAMMEEIAGFE 3906
+ K E L+ + +V DK+ +L QD + G + + E+I +
Sbjct: 3565 --NAKIFGEDEVELMNWLNEV--HDKLSKL--SVQDYSTEGLWKQQSELRVLQEDILLRK 3618
Query: 3907 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 3966
++ + G L+ Q ++ + A KD A+ + Q+L+ +
Sbjct: 3619 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3678
Query: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4026
H T ++ WL V+ +L L EA + + L+++A+ LL S+
Sbjct: 3679 H----STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3734
Query: 4027 DLSNASVKTTAKDIQQ-----TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQ 4081
++S+A ++ ++ + E+ + + +TQ EEI + Q AD +
Sbjct: 3735 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3794
Query: 4082 L----QNMKRRHSELELNIAQNMVS---QV-KDFVKKLQSKQASVNTIIEKVNKL----T 4129
L + K+ S ++ + Q+ S QV K F ++ + ++ +++ +K+ +
Sbjct: 3795 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3854
Query: 4130 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4189
++E+ K+++ + + +C+ ++ LQ E ++V F E + W
Sbjct: 3855 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLER----------AQSLVNQFWETYEELW 3904
Query: 4190 DNLARSDAESTAVHLEALKKLALALQERKY-AIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248
L + + + + AL+ L Q+ ++ + +L + + I+ +N +L++
Sbjct: 3905 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3964
Query: 4249 H---LEQRWFQLEDL---IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302
+++++ + L IK ++ L+E ++F + ++ E I E L+Q
Sbjct: 3965 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4024
Query: 4303 SP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
P + + + ++ + ++E Q L ++L + + ++A G ++ + KA+ D
Sbjct: 4025 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4084
Query: 4359 AQSHV----NCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
+ + LV +R L + +F I+ + I E +
Sbjct: 4085 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4144
Query: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
P V +Q + ++ + + Q E+ + G EL+ E +K V + EL S +DS
Sbjct: 4145 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4204
Query: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT---QL 4531
+ + R+ +LE+ + + +++ W+ DI ++ ++L T Q+
Sbjct: 4205 LNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV---DIAGGKLASMSPIGTDLETVKQQI 4261
Query: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKD 4590
+ + ++ + + + L + +L + E D + + L L ++ + +
Sbjct: 4262 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD-LAVEEALS----LQDGC 4645
+ +K++ A+LA ++ ++ L+ E V D A+E L+ LQ+
Sbjct: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
A V + +A ++L + G ++ +K+ L + + +TEQR L+
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4438
Query: 4706 TSAYQEHEKMCQQLERQLKSVKEE---QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK 4762
+ + L++ L + + A+E+L ++ + + + K
Sbjct: 4439 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4498
Query: 4763 RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEM 4822
+ + + A I + + + + + + + E T+ E + +++F +
Sbjct: 4499 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4558
Query: 4823 SRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEK 4880
++WL + + L+ L L + +I + ++ EV S + L + +
Sbjct: 4559 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4618
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
F++ ++++ +++ L + + + L R +L + + +++++ + +WLE+
Sbjct: 4619 FSQKQDVVL--IKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4676
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTG 4996
+++ L + L++ + + +K+ + + +F +L HS+ T + L + T
Sbjct: 4677 SEKSLD---SELEIANDPDKIKTQL---AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTS 4730
Query: 4997 KED----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKK 5052
D L+ ++ L + + S + + L+ + A + +I+ + E +
Sbjct: 4731 LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ 4790
Query: 5053 LSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSR 5112
L+E + + HKA + + AL+ A +L + D S + +
Sbjct: 4791 LAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKV 4848
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
M + RW + A++ ++ LE A+ + F++ V E + + + L
Sbjct: 4849 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4908
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
+ L TL++ H F+ +LE++++ L ++L A P + IT ++ R
Sbjct: 4909 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL---AICHPDSITTIKHWITIIRAR 4965
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ--------ETKEYLGNPTIEIDA 5284
+ K + + + L + + ++ W+Q + KE + E+ A
Sbjct: 4966 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5025
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEK 5313
+ E Q + E T + +++K+ + K +
Sbjct: 5026 LIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054
Score = 276 bits (707), Expect = 5e-73
Identities = 777/4352 (17%), Positives = 1650/4352 (37%), Gaps = 709/4352 (16%)
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQ----ADEMDRMKKEYTDCVVTL-----SAFATEAHK 736
++QQ + W E + +K +E+DR++ + T+ +
Sbjct: 995 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1054
Query: 737 KLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
+ + LE S + D+ +E+ V V Y+ + K+A +E +E ++ +
Sbjct: 1055 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE---REEQEESVYNLY--I 1109
Query: 797 SKLKEQLTKVKECYSPL------------LYESQQLLIPLEELEKQMTSFYDSLGKINEI 844
S+++ +++ C L L+ES + E+L+K++ D LG I
Sbjct: 1110 SEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNK 1169
Query: 845 ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD---- 900
+A +S+ EL +N + ++ S + K T++ VLK+
Sbjct: 1170 CEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSM---SSTYIDKLKTVNLVLKNTQAAEA 1226
Query: 901 -----QTRLQRQ---IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRI 952
+T+L + IAD + ++++ W+ V+ ++ E+ EL+K I
Sbjct: 1227 LVKLYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALED---ELQKAKAI 1282
Query: 953 AQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDI--------LPEQEQQGL 1004
+ E + + + H E QL +R N ++ + L D+ L
Sbjct: 1283 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPL 1342
Query: 1005 QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLAS-VEECRTELDRETKLMPQEGS-- 1061
+ ++++ + +Q P + L + + + L S +E ++++D K Q +
Sbjct: 1343 DDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV 1402
Query: 1062 ---EKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVK--LPVRDPVRDTPGTCHVTL--KE 1114
E +R + + +R+Q +L ++ + +R T T VTL +
Sbjct: 1403 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR-----TRYTALVTLMTQY 1457
Query: 1115 LRAAIDSTYRKLMEDP---DKWKDYTSRFSEFSSWISTNETQLKG-------------IK 1158
++ A DS R E+ ++ K++ + E W+S LK I
Sbjct: 1458 IKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1517
Query: 1159 GEAIDT----------------ANHGEVKRAVEEIRNGVTKRGETLS-----WLKSRLKV 1197
E I T A HG+ + +E RN + K+ +TL LK
Sbjct: 1518 SEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERNELEKQVKTLQESYNLLFSESLKQ 1575
Query: 1198 LTEVSSENEAQKQGDELAKLSSSFK----ALVTLLSEVEKMLSNF--------------- 1238
L E + + + + +A+ +K + LL++ E L
Sbjct: 1576 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKK 1635
Query: 1239 -------------GDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEA----QQL 1281
G E+VKN+ E + + E Q +K L + L EA +QL
Sbjct: 1636 YQSKQEELQKDMQGSAQALAEVVKNT-ENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1694
Query: 1282 LLHHQQKTKR----ISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRER 1337
L +Q K ++ ++ +++A +Q E E K+E+ LD L +
Sbjct: 1695 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE--------ESKTKIENLLDWLSNVDKD 1746
Query: 1338 QER----RIQVTLRKWERFETN--------KETVVRYLFQTGSSHERFLSFSSLESLSSE 1385
ER QV + F+ ++ V L +T + ++ E+L+ +
Sbjct: 1747 SERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ---VGTTQENLNQQ 1803
Query: 1386 LEQTKEFSKRTES------IAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439
++ K ++ S IA Q+ ++ E L P+ K+ LQ+ K +K +
Sbjct: 1804 YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1863
Query: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK----- 1494
E+ +K ++ + + F +++ W+ + E+EL LE + ++ ++++K
Sbjct: 1864 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1923
Query: 1495 ---VTIQEIESKLSSIVG--LEEEAQSFA-----QFVTTGESARIKAKLTQIRRYGEELR 1544
V + + + +I G + E A+S + + T+ ++ KL L
Sbjct: 1924 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1983
Query: 1545 EHAQCLEGTILGHLSQQQKFEE-------NLRKIQQSVSE-FEDKLAVPIKICSSATETY 1596
L + + + Q +E+ L+ + + S+ + +AV K E
Sbjct: 1984 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEET 2043
Query: 1597 KVLQEHMDLCQ-ALESLSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQ 1654
K LQ + Q A+E L + ++ + +Q+ + +YED+ + ER
Sbjct: 2044 KALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERN 2103
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
L+ L ++ L L W+ E+ +K +G++ L +++
Sbjct: 2104 EKLQITLTRSLSVQDGLDEMLDWMGNVESS------------LKEQGQVPLNSTALQDII 2151
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKMMKL----HLEQLDERWRDLPQIINKRINFLQSV 1770
S+ + + ++S + ++ K M+ L + +DL ++ + +
Sbjct: 2152 SKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2211
Query: 1771 VAEHQQFD---ELLLSFSVWIKLFL-SELQTTSEISIMDHQVA-LTRH-KDHAAEVESKK 1824
+A+ ++ EL + S ++ FL ++ Q +E+ + V L+++ ++ +E K
Sbjct: 2212 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2271
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSH 1884
L+ L L ++ S G D L+ K + + F+E ++ ++ A++ E L +
Sbjct: 2272 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2331
Query: 1885 ASLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKALE--------------SA 1929
L ++ L+ + E T + + +DL +L++ K L+ ++
Sbjct: 2332 QVL---VKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2388
Query: 1930 AVSLDGILS------KAQYHLKIG-----------------SSEQRTSCRATADQLCGEV 1966
+SL ++S KA +K G +++ TS + +
Sbjct: 2389 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2448
Query: 1967 ERIQNLLGTKQSEADA-LAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPT-RQALQQ 2023
E + LL K +E + L+ L+KA Q++ +++ ++ + + K ++ PT +A++
Sbjct: 2449 EDLGLLLKDKIAELNTKLSKLQKA-QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2507
Query: 2024 RLRVFNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRLI 2081
++ E EL + +++ LKDK ++ ++ D AP + + ++ W + +L
Sbjct: 2508 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2567
Query: 2082 HENQGQCCGLIDLMREYQNLKSAVSK-VLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ Q + + + ++Q +++ + + ++E V V D L + +
Sbjct: 2568 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2627
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLR 2200
+ ++ + T+ G+ +LS + S +VK + + KW ++ +L + D +
Sbjct: 2628 EFATRKPQYEQLTAAGQGILSRPGE-DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWID 2686
Query: 2201 VSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE--------------ELLKE 2246
++ V ST+ + + + +++ +S+LDN L + E ++
Sbjct: 2687 QAI-----VKSTQYQ------SLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735
Query: 2247 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLE----HAKEITEVA 2302
+ E++ + +++ + DL L K ++++A+L ++LE K++ + A
Sbjct: 2736 MKQEIQQEKKQIKVAQALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKA 2788
Query: 2303 KG---TLKDFTAQSTQVEKFINDITTWF-TKVEESLMN---CAQNETCEAL-KKVKDIQK 2354
+ L+ A S Q ++ D W TK EE + A+ + E+L K KD K
Sbjct: 2789 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2848
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
L +Q T +L K +E +L + + + ++ + + L+ESL
Sbjct: 2849 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2908
Query: 2415 EK--HFSESMQEFQEWFLGAKAAAKE----SSDRTGDSKVLEAKLHDLQNILDSVSDGQS 2468
EK + E ++ W + +E G++ + AKL LQ +D G
Sbjct: 2909 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI--AKLKSLQKEMDQ-HFGMV 2965
Query: 2469 KLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFE 2528
+L T + K++V+ + + ++ +Q K L++ + F+
Sbjct: 2966 ELLNNTANSLLSVCEIDKEVVTDENKSLI---QKVDMVTEQLHSKKFCLENMTQKFKEFQ 3022
Query: 2529 DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRG 2588
+ ++ + +E+ + + S+ + + + + L L + +L+Q
Sbjct: 3023 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3082
Query: 2589 QLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2648
+ + + G + H L + EK + LQ + ++ M+
Sbjct: 3083 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3142
Query: 2649 AIQDRLAC-------AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQA--- 2698
D L AE+ K+T++ L +++ ++ M + E +
Sbjct: 3143 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3202
Query: 2699 ------LRSSNKEGQRV----------IQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
L + +K+ ++ ++ ++ L+E ++ + S+ Q E SQ
Sbjct: 3203 VGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3262
Query: 2743 NDYVERKNQLEQW-MESVDQKIE-HPLQPQ--------PGLKE---KFVLLDHLQSILSE 2789
+E + +Q M V QK E PLQ + GL + K L+ L +
Sbjct: 3263 PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3322
Query: 2790 AEDHTRALHRLIA-KSRELYEK-TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE-EIV 2846
+ L++ +A ++ +L E F+D + L + VA +K E ++V
Sbjct: 3323 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3382
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKE--LIDSR------- 2897
K + + D S E + R + ++ K+ +K+ L+DSR
Sbjct: 3383 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3442
Query: 2898 -EIGASRLSRV--------ESLAPEVKQNTTAS----GCELMHTEMQALR---ADWKQWE 2941
E +L + E+L P + TT CE + T+ L A K E
Sbjct: 3443 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3502
Query: 2942 DSVFQTQSCLENLVS--------------QMALSEQEFSGQVAQLEQALEQFSALLKTWA 2987
D + L VS M S+ +FS QV +E + S ++
Sbjct: 3503 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS-QVWYIEIQEKSHS---RSEL 3558
Query: 2988 QQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR---TEDLKSQLNELCRFSRDL---- 3040
Q L K E+ VE + E+ D L K + TE L Q +EL D+
Sbjct: 3559 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3618
Query: 3041 ----------------------STYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ--QRF 3076
K+ + Y + ++ + EQ LQ +R
Sbjct: 3619 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3678
Query: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136
+ WL ++ E S + + +E E++N + L+ +
Sbjct: 3679 HSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3738
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
L L+ +G++ V E ++ + QK ++ ++ + F+ +A+ W+
Sbjct: 3739 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3798
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE------- 3249
++TEK +L L R EQ + + L+ + ++ R K+ L +
Sbjct: 3799 TETEK-------KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3851
Query: 3250 --GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3307
+ +S + ++ ++ Y + + E+ +L+R + NQF +EL W+T+
Sbjct: 3852 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3911
Query: 3308 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3367
++ P + L + + L + E + + + G +L+ + EG +IQ
Sbjct: 3912 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF-SIQ 3970
Query: 3368 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3427
++ + +++ + + L+ A+S+ T + D + Q L ER
Sbjct: 3971 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI----------LESLERIVE 4020
Query: 3428 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3487
LR ++ + + + E++ +E+ ++++ LQ Y +++R
Sbjct: 4021 RLRQPPSISAEVEKIKEQI-----------------SENKNVSVDMEKLQPLYETLKQRG 4063
Query: 3488 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHT----HETTLRDLQ 3543
+E + +S +D+ A V Q+KLDQ + + HT E L D+
Sbjct: 4064 EEMIARSGGT-------DKDISAKAV-----QDKLDQMVFIWENIHTLVEEREAKLLDVM 4111
Query: 3544 EL-QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
EL + + +L+ ++ T++ + P + ++ ++ + + + + + +
Sbjct: 4112 ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDI 4171
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC 3662
V+N E+ A E ++ ++ +DE
Sbjct: 4172 VIN-----------------------LGSELIAACGEPDK--PIVKKSIDE--------- 4197
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
L S + +L ++I LEE +Q+ + + L + DW +++
Sbjct: 4198 ----LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP---- 4249
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER----AVKYLEEGEAERLRKEIHDH 3778
+G L+T++ ++++++ S + + ER A L++ E + + D
Sbjct: 4250 -----IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP 4304
Query: 3779 MEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMEL 3834
+ +LK L + LE L +F L W+ + +L + +
Sbjct: 4305 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4364
Query: 3835 YEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL---VQDVTLKDKIDQLQSDYQDL 3891
+ +L+K+ LQ VL+H+ +V++V + G L+E + L++K++ L +Q++
Sbjct: 4365 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4424
Query: 3892 CSIGKAMMEEI-------AGFEDRLNNLQ------------------------------- 3913
+ +++ GF + +LQ
Sbjct: 4425 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4484
Query: 3914 -----------------MKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
KG ++ +C + + Q+++ K+ + ++ +
Sbjct: 4485 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN----NLKEKWESVETKLNER 4540
Query: 3957 YQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQAR 4016
LE L + ++LQ WL+ + L + +P L + Q+ + +
Sbjct: 4541 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN 4600
Query: 4017 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQ 4076
++ + + + D + +K ++ +Q I+ L+ Q+ WE++ E L
Sbjct: 4601 SHREQIIEL-DKTGTHLKYFSQ--KQDVVLIKNLLISVQS---RWEKVVQRLVERGRSLD 4654
Query: 4077 DADQQLQNMKRRHSEL-------------ELNIA------QNMVSQVKDFVKKLQSKQAS 4117
DA ++ + S+L EL IA + ++Q K+F K L +K +
Sbjct: 4655 DARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSV 4714
Query: 4118 VNTIIEKVNKLTKKEESPEHK-----EINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYH 4172
+T L +K + ++ L D+W +C +S + EE L + +
Sbjct: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774
Query: 4173 DCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK 4230
D + + +L + + D D + ++ K L +R +++ LK ++
Sbjct: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834
Query: 4231 MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAE 4290
+IE + DD VK Q L RW + L K L + S L+EW
Sbjct: 4835 LIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 4893
Query: 4291 EQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNE-- 4348
E + + D + L+ H +LE K+ L D V+A +
Sbjct: 4894 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSIT 4953
Query: 4349 ---------RQVIQKALSDAQSH----VNCLSDLVGQRR---------KYLNKALSEKTQ 4386
R ++ L+ A+ H + L+ L+ ++ ++ L++K +
Sbjct: 4954 TIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDK 5013
Query: 4387 FLM--AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEV----- 4439
++ + + + I +H+ F E + DV K KT K A + Q+ +
Sbjct: 5014 EVIPQEIEEVKALIAEHQ---TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDK 5070
Query: 4440 ----------TGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
+ L+ G + E + ++ K Q++ + +K + L LE+
Sbjct: 5071 GRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEE- 5129
Query: 4490 LVSRKHFKEDFD----KACHWL--KQADIVTF 4515
R+ DFD K W+ K++ ++ F
Sbjct: 5130 --LREFANFDFDIWRKKYMRWMNHKKSRVMDF 5159
Score = 270 bits (691), Expect = 4e-71
Identities = 840/4709 (17%), Positives = 1807/4709 (38%), Gaps = 678/4709 (14%)
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1434
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 669 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 724
Query: 1435 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1494
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 725 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 778
Query: 1495 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1548
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 779 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 835
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1603
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 836 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 891
Query: 1604 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1653
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 892 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 951
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1712
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 952 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 1009
Query: 1713 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1761
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 1010 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1061
Query: 1762 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1821
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1062 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1113
Query: 1822 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1880
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1114 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1173
Query: 1881 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1934
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1174 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1230
Query: 1935 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1991
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1231 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1273
Query: 1992 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2045
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1274 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1325
Query: 2046 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2101
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1326 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1380
Query: 2102 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1381 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1437
Query: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1438 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1493
Query: 2221 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2267
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1494 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1553
Query: 2268 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2327
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1554 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1610
Query: 2328 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2383
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1611 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1670
Query: 2384 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2437
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1729
Query: 2438 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2464
+ S+R G +V+E Q N+L++
Sbjct: 1730 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1789
Query: 2465 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2494
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1790 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1849
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1850 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1907
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2612
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1908 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958
Query: 2613 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2668
+ +E R A +L + +K + D+ E L E
Sbjct: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018
Query: 2669 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2078
Query: 2729 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2079 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2135
Query: 2789 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2825
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2136 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2195
Query: 2826 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2881
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2196 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2255
Query: 2882 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2941
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2256 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2311
Query: 2942 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2980
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2312 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2369
Query: 2981 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2370 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2428
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2429 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2482
Query: 3087 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3143
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2483 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2542
Query: 3144 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3203
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2543 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2602
Query: 3204 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3259
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2603 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2662
Query: 3260 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3319
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2663 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2722
Query: 3320 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3378
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2723 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2782
Query: 3379 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3438
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2783 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2842
Query: 3439 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3492
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2843 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2902
Query: 3493 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ--YSVLEGDAHTHETTLRDLQ-ELQVHC 3549
K ++ + +Y+ ++ W+ + Q L++ + + + L+ LQ E+ H
Sbjct: 2903 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2962
Query: 3550 AEGQALLN------SVLHTREDVIPS---GIPQAEDRA----------LESLRQDWQAYQ 3590
+ L N SV ++V+ + Q D LE++ Q ++ +Q
Sbjct: 2963 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3022
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQV--DEWLKTAEEKKWHEEVTAYRDEVEEVGARAQ 3648
E++ Q +L + + Q +++L + ++ + + A + +V+ AQ
Sbjct: 3023 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ--KSLQALKHQVDLAKRLAQ 3080
Query: 3649 EILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3705
+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3081 DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3140
Query: 3706 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3765
+ ++A +T+ K+ +T++ LK +E L ++ + + K +
Sbjct: 3141 FAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKTCKMMLA 3194
Query: 3766 GEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEY 3820
E +++++ +Q +L + +E + +EF K K + + +
Sbjct: 3195 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3254
Query: 3821 QEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK 3880
+E ME QL+ +K Q K++
Sbjct: 3255 EEHEESQGPVGMETETINQQLNMFKVFQ-----------------------------KEE 3285
Query: 3881 IDQLQSDYQDLCSIGKAMMEEIA------GFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 3934
I+ LQ QD+ +G+ +++ A G E L+++ + TL +
Sbjct: 3286 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK------------ 3333
Query: 3935 VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSR-QDTLQQCQAWLSAVQPDLEPSPQ 3993
AQR Q E L H R QD L+ +W+ + +L + +
Sbjct: 3334 -----------------VAQRAAQLQEALL--HCGRFQDALESLLSWMVDTE-ELVANQK 3373
Query: 3994 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK--- 4050
PP + + +K +QEQ LL + D ++V+ ++ ++ T E
Sbjct: 3374 PPSAEFKVVKA-----QIQEQK-----LLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423
Query: 4051 --LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM----KRRHSELELNIAQNMVSQV 4104
L Q L WE + + K+E ++QL+ + ++ H LE +
Sbjct: 3424 KILKQLSLLDSRWEALLN-KAET------RNRQLEGISVVAQQFHETLE---------PL 3467
Query: 4105 KDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4164
+++ ++ + + I + +KL +E+ +HK + ++
Sbjct: 3468 NEWLTTIEKRLVNCEPIGTQASKL--EEQIAQHKALE--------------------DDI 3505
Query: 4165 LQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ + H +++ + + E ++ +S + + V + +QE+ ++ +L
Sbjct: 3506 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY-------IEIQEKSHSRSEL 3558
Query: 4225 KDQKQKMIEHLNLDDKEL------VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVV 4278
Q + D+ EL V ++ S L + + E L K++ ++ V + L
Sbjct: 3559 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3618
Query: 4279 QSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDAD 4338
Q+ Q L+ N E LKQ+ ++ L I +LEA +K+ KD
Sbjct: 3619 QNVDQALL--------NGLELLKQTTGDEV--------LIIQDKLEA----IKARYKDIT 3658
Query: 4339 RVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQI 4398
++ D+ Q +Q A +H +L K + LS +TQ L + SQ
Sbjct: 3659 KLSTDVAKTLEQALQLARRLHSTH----EELCTWLDKVEVELLSYETQVLKG--EEASQA 3712
Query: 4399 QQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL--WAQGRELMKEVTEQ 4456
Q P ++ K+ K K+ SL + + L W L K V E
Sbjct: 3713 QMR-------------PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED 3759
Query: 4457 EKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD--IVT 4514
+ + V D++ QK ++E++ ++ + F + D W+ + + +++
Sbjct: 3760 N--------ERYRLVSDTITQK----VEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3807
Query: 4515 FPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKL 4574
+I L E + QL + + +++++ L ++G I+ + +E + + +KL
Sbjct: 3808 LGDIRL--EQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3865
Query: 4575 NALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLA 4634
+ + + ++ I + +++ +++ A ++ E L+E ++ +S++P
Sbjct: 3866 DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI---ISQLPAPAL 3922
Query: 4635 VEEAL-SLQDGCRAILDEVAGLGEAVDELNQKKEGFR--STGQPWQ-PDKMLHLVTLYHR 4690
E L Q+ R + + +A +D++N+ S G+ + +K + TLY +
Sbjct: 3923 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3982
Query: 4691 LKRQTEQRVSLLEDTTS-AYQEHEKMCQ---QLERQLKSVKEEQSKVNEETLPAEEKLKM 4746
+K ++R L++ S + Q H+K+ Q LER ++ +++ S ++ E +E++
Sbjct: 3983 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPS-ISAEVEKIKEQISE 4041
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+++ ++ + + + E++ + + +Q ++ + I V
Sbjct: 4042 NKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVE 4101
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQI-------- 4858
E E++++ ++ + W + L + ++D Q+ IR ++
Sbjct: 4102 EREAKLLDVMELAEKF-----WCDHMS--------LIVTIKDTQDFIRDLEDPGIDPSVV 4148
Query: 4859 --HQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELSELDGDIQEA 4909
QE ++ ++ L + ELI+A ++ S+ EL+ + +A
Sbjct: 4149 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4208
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEENLKSHMEFF 4968
+ R L E +Y QA DW++ A +L ++ G D+E+ ++ ++ +F
Sbjct: 4209 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4268
Query: 4969 STEDQFHSNLEEL-HSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027
S Q +E L H L + + + K ++ + L+L + + L+
Sbjct: 4269 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4328
Query: 5028 CTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 5087
+Q A +E++ + TE LSE + E +L++H L + V +
Sbjct: 4329 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVG-GDPKAIEIELAKHHVLQNDVLAHQST 4387
Query: 5088 IVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNN 5147
+ A+ + + L ++ + L + + QRW + + +++ L+ A+ + GF+
Sbjct: 4388 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4447
Query: 5148 KVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSM 5207
+++ + + + L S L H E ++ L Q+ M
Sbjct: 4448 EIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4507
Query: 5208 LQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCW 5267
L A E + Q+I ++++ +++ K+ +++ L + W
Sbjct: 4508 L---ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
Query: 5268 VQETKEYLG---NPTIEIDA---QLEELQILLTEATNHRQNIEKMAE--------EQKEK 5313
+ + ++ L P++ +D Q++E ++ E +HR+ I ++ + QK+
Sbjct: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
Query: 5314 YLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
+ + +L S S V ++ + D K +Q +L +++ K L +
Sbjct: 4625 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4684
Query: 5374 LTKL----KAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK 5429
L K KT + Q K QK LG + + + + L++ L K
Sbjct: 4685 LEIANDPDKIKTQ-LAQHKEFQKSLGAK-----HSVYDTTNRTGRSLKEKTSLADDNLKL 4738
Query: 5430 IGKLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN 5486
L+EL + ++ R +KL +A ++ + L+ ++ W+ + +
Sbjct: 4739 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE---------- 4788
Query: 5487 SASQLREQYILH------QTLLEESKEIDSELEAMTEKLQYLT---------SVYCTEKM 5531
QL E +H L++ K EL T +Q L S + +
Sbjct: 4789 --PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4846
Query: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV-- 5589
Q+ EL E + + + L+ A + ++F + + L L +A+ TL V
Sbjct: 4847 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4906
Query: 5590 -GRLSLKEQLSHRQHLLSEMESLKPKV-QAVQLCQSALRI--PEDVVASLPLCHAALRLQ 5645
+L+ + + + ++E + ++ +A + + L I P+ + + H ++
Sbjct: 4907 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITT---IKHWITIIR 4963
Query: 5646 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI--EDKPVATSNIQEL 5703
+ A Q + +A+ ++ ++ L ++ A + +DK V I+E+
Sbjct: 4964 ARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5023
Query: 5704 QAQISRHEELAQKIKGYQEQIASLNSKCK 5732
+A I+ H+ +++ Q + + K
Sbjct: 5024 KALIAEHQTFMEEMTRKQPDVDKVTKTYK 5052
Score = 270 bits (691), Expect = 4e-71
Identities = 774/4191 (18%), Positives = 1624/4191 (38%), Gaps = 555/4191 (13%)
Query: 4702 LEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVL 4761
L S + H+ + + +E S+KE +K++E + A KL Y L+ L
Sbjct: 671 LPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLT-YAEKLHRLESQYAKL 727
Query: 4762 KRVTIHLEDLAPHLDPLA--YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
+ + E HLD L +A +++ W E + + +E + + + D+
Sbjct: 728 LNTSRNQER---HLDTLHNFVSRATNEL-IWLNEKE--EEEVAYDWSERNTNIARKKDYH 781
Query: 4820 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4879
E+ R LD N++ +QE ++ + + ++ A +
Sbjct: 782 AELMRELDQKEE-------------NIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWS 828
Query: 4880 KFTKAKELISADLEHSLAELSELDGDIQEA---LRTRQATLTEIYSQCQR---YYQVFQA 4933
+ + + ++ + A E D +EA LR + + YS C R +++
Sbjct: 829 WILQLCQCVEQHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYS-CDRSSSIHKLEDL 886
Query: 4934 ANDWLEDAQELLQ-------LAGNG-----LDVESAEENLKSHMEFFSTED--QFHSNLE 4979
+ +E+ +ELLQ L G L +++ LK+ + + D Q +
Sbjct: 887 VQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIY 946
Query: 4980 ELHSLVATLDP------LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL-LQRCTAQW 5032
+ V + +I PTG E + V + + D +++ Q W
Sbjct: 947 KDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW 1006
Query: 5033 HDYQKAREEVIE---LMNDTEK-KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI 5088
H+ + V+ L+N+ ++ + S + +KT EH+ ++S + S E
Sbjct: 1007 HESHINMKSVVSWHYLINEIDRIRASNVASIKTMLP-------GEHQQVLSNLQSRFEDF 1059
Query: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
LE+ +G+D ++ L + + Q + L A+ +E+ E++V + + ++
Sbjct: 1060 --LEDSQESQVFSGSDITQ--LEKEVNVCKQYYQELLKSAEREEQ--EESV--YNLYISE 1111
Query: 5149 VKKATEMIDQLQDKLPG---SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTL 5205
V+ ++ +D+L + E+ E + + + ELE+ + LG + +
Sbjct: 1112 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1171
Query: 5206 SMLQDGAAPTPGEEPPLMQEITAM---QDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262
AA + P L E+ + ++ +M K V LK+ + E +
Sbjct: 1172 EFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1229
Query: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTIL 5321
+ + E + + + I+ + L+ +E RQ + +E QK K +
Sbjct: 1230 LYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS----- 1283
Query: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
E+ E LD + D++ E Q + QI +DL I LK
Sbjct: 1284 -DEMFKTYKERDLDFDWHKEKADQLVE------RWQNVHVQIDNRLRDLEGIGKSLKYYR 1336
Query: 5382 DN-------VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLT 5434
D + Q +T Q+ + E NSK + QK L ++ + + K
Sbjct: 1337 DTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1395
Query: 5435 ELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW-IEKAKVLAHGTIAWNSASQLRE 5493
E + T++ E + Y M++ K +++ ++ + + LR
Sbjct: 1396 EQYSATVKDYELQTMT----------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1445
Query: 5494 QYILHQTLL---------------EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538
+Y TL+ EE K ++ E + EK + L + + AE
Sbjct: 1446 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1505
Query: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598
+ +Q I + ++ + ++ L+ +Q L + +T E L + +
Sbjct: 1506 AGKPPFSKQKI-----SSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1560
Query: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP---------LCHAALRLQEEAS 5649
+ L ESLK ++Q Q +++ E +VA +C L Q E
Sbjct: 1561 LQESYNLLFSESLK-QLQESQT-SGDVKVEEKIVAERQQEYKEKLQGICD--LLTQTENR 1616
Query: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 5709
+ H Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + + T N +
Sbjct: 1617 LIGH---QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLK-----EN 1668
Query: 5710 HEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
E+L+Q+ K EQ + KC+ L +KA+ + L + E TE +
Sbjct: 1669 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1728
Query: 5769 SAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGTN-SEISSPPACRS------ 5810
S S V + R T V E++G +EG S I
Sbjct: 1729 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1788
Query: 5811 -PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 5867
V T ++NQ YQ + A E++ + + +T ++Q E + + +
Sbjct: 1789 VDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKE 1845
Query: 5868 DLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5926
LQ++ + LK YE AL +K S+ ++E + +E + E
Sbjct: 1846 KLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE 1897
Query: 5927 SQMAEHQALMDEILMLQDEINELQSSLAEELVS-------------------ESCEADPA 5967
++ +A D+I L ++ Q S +E+++S +SC
Sbjct: 1898 QELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1956
Query: 5968 EQLALQSTLTVLAERM--STIRMKAS-GKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL 6024
++ +T + ++ +T R ++ K +L L D +++ Q Y + L
Sbjct: 1957 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY------QHYEDASCGL 2010
Query: 6025 DSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
+ L + +AT LS P +P +++ QL + + + +I + VA+ +L E +LL+
Sbjct: 2011 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAE-VLLD 2069
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 6142
+ + L + G +L ++++++ +Q +T T+S VQ
Sbjct: 2070 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------------ITLTRSLSVQ 2117
Query: 6143 EWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSVASRGEEILIQHSAAE 6195
+ L + W +SSL++Q + L+ +++ L + +A R I + +
Sbjct: 2118 DGLDEM-LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2176
Query: 6196 TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH--QEFSTKQKLLQNVLEQEQEQV 6253
+ + S + M+ + + E+L +E TK +L +N+ E+ Q
Sbjct: 2177 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL--SEKLQT 2234
Query: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY 6313
+ L+ V DVP +D + L+Q +E +S+ K+ L L
Sbjct: 2235 FLETKTQALTEV-----DVPGKDVTE-------LSQYMQESTSEFLEHKKHLEVLHSLLK 2282
Query: 6314 DGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAF 6373
+ +++ LP + L L+K KEM + + + K +
Sbjct: 2283 E-----------------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC- 2324
Query: 6374 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQILNFQN--DLKVLFTSL 6429
E D V+ +L + + +V + + L+ Q LK
Sbjct: 2325 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384
Query: 6430 ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------ 6483
+N I L L + P A+ I A++ +G L G E+
Sbjct: 2385 VNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNGEGTATNTEEFWANKG 2433
Query: 6484 --PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540
++++ + Y++L +++ + + LN L+ L+ E + + L + +
Sbjct: 2434 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2493
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET--------QFH 6592
Q + E ++ ++++K + L+ ++ + L K+ + Q
Sbjct: 2494 QQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQML 2553
Query: 6593 TELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 6652
TE+ ++ + + R +LE + + +L + L E + +G + + +
Sbjct: 2554 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2613
Query: 6653 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD------LESQLNQLGECWL 6706
L + Q L +P+ Q+ G+ +L S D ++ QL + + W
Sbjct: 2614 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLRGIVKEQLAAVTQKWD 2672
Query: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
S T ++S ++ + T+YQS L L ++L S+ V + +
Sbjct: 2673 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS----SSLAVSTHPDAMNQ 2728
Query: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 6826
L + +E+ + + L L K + L++ELSR Q +L +
Sbjct: 2729 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSR---QLEGILKSFKD 2783
Query: 6827 VQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDEDNIKNSIGYK--AIHE 6877
V++K Q S H ++ +W+ +K+E N + I K +
Sbjct: 2784 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT-----KKEEQNKSHPISAKLDVLES 2838
Query: 6878 YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG 6937
++ +K F + + +++ + + ++++ S+K QL + +W
Sbjct: 2839 LIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2895
Query: 6938 LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997
V E+ L+ LE +Y+ V+ L W + + L++ D A +N++ + L+
Sbjct: 2896 QVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQ 2955
Query: 6998 ------------------DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST---LREL 7036
L+ E + E + +LIQ K + V+ + S L +
Sbjct: 2956 KEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCLENM 3014
Query: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096
Q + + + K L+ +Q H D + S +Y L+ + SL+A++
Sbjct: 3015 TQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY-LTMLQTQQKSLQALK 3069
Query: 7097 VQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
QVD + L DL + E Q+ +++ Q+ ++C L L
Sbjct: 3070 HQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC-----SFLETKL 3124
Query: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
+ + N + E ++ + L + +D A T+Q+Q++ LK
Sbjct: 3125 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQKETIKAFLKKLEALM 3179
Query: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
++D + C +L T D + I+ D +LS+
Sbjct: 3180 ASNDNAN---KTCKMMLATEETSPDLV--------------------GIKRDLEALSKQC 3216
Query: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322
L ++ ++ + E F L+ + +AEE + Q P + TI +++
Sbjct: 3217 NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV-GMETETINQQL 3275
Query: 7323 EELKG-QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL-------NRHWSLISSQTT 7374
K Q + + +N LG L + + Q L N W ++ +
Sbjct: 3276 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3335
Query: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRAHELFQAE 7432
+R ++LQ LL F + E+ + ++V TE+ +A + S ++ + Q + +L Q
Sbjct: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395
Query: 7433 MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7492
+ R+ + I +G+++ + D+ + +L+LL ++W+ ++ +A+ R ++
Sbjct: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3455
Query: 7493 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVFLRQQGSY 7550
Q++ E E L +WL + ++ PI Q ++ Q K E +
Sbjct: 3456 VAQQFHETLEPLNEWLTTIEKRLVN---CEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3512
Query: 7551 ILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASMRLEEQKKKLAFLLKD 7603
V G+ L + + + +Q++L EIQEK S S L++ +D
Sbjct: 3513 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572
Query: 7604 WEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQ----MRCKELENAVGSWTDDL 7657
+ + + +KL + ++ L EL Q +R + ++ A+ L
Sbjct: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQAL------L 3626
Query: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
L LLK T + D++ I+ +++E ++ +++++ + + + + L
Sbjct: 3627 NGLELLKQT-----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3681
Query: 7718 NKELCEWLTQMESKV-SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKAS 7776
++ELC WL ++E ++ S +L E + + +E A+ NK L + E ++ A
Sbjct: 3682 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNE-VSSAL 3740
Query: 7777 HES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 7832
E +A E +E + + N+R++ + D I +V+++ ++ QQ D+ + +W+
Sbjct: 3741 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3800
Query: 7833 IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7892
E +L + ++ +L Q+ +I +H + ++ ++ C ++
Sbjct: 3801 TEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC----SE 3855
Query: 7893 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 7952
E S+++ + + + IC ++ ER L++E L +F + Y WL ++ +
Sbjct: 3856 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3915
Query: 7953 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 8012
+ + Y +++ ++ + + E ++ +NK +L E S+++
Sbjct: 3916 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGEGFSIQEKYV 3974
Query: 8013 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8072
+ + +++ V L I Q +F D IL L + +L S +V+
Sbjct: 3975 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS-AEVE 4033
Query: 8073 AKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIEEELDELRRY 8124
KIK+ + + +S++ K+ E + +GE++I +S + + A ++++LD++
Sbjct: 4034 -KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFI 4092
Query: 8125 CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 8184
+ + VE +RE +L D L++ W D + +++ + +
Sbjct: 4093 WENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS-LIVTIKDTQ 4132
Query: 8185 NLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
+ L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4133 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC--------- 4183
Query: 8238 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 8297
G+ DK + I E A+ L + A+++ + Q L
Sbjct: 4184 -GEPDKPIVKKS--------IDELNSAWDSLNKAWKDRIDKLEEAMQAAV-QYQDGLQAV 4233
Query: 8298 RFQIQQTENIIRSKTPTGPELDTSYKGYMKLL---GECSSSIDSVKRLEHKLKEEEESLP 8354
+ + S +P G +L+T + +L E ++RL H+ + + +
Sbjct: 4234 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4293
Query: 8355 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8414
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4294 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4353
Query: 8415 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 8473
L + + + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4354 LSEQK--PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4411
Query: 8474 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 8533
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4412 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4471
Query: 8534 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 8578
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4472 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4524
Query: 8579 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8629
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4525 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4569
Score = 270 bits (691), Expect = 4e-71
Identities = 734/4041 (18%), Positives = 1546/4041 (38%), Gaps = 628/4041 (15%)
Query: 449 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1152 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1209
Query: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
K++ + L +L AE+ +K + K E+V N + I K +
Sbjct: 1210 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE----- 1261
Query: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
+ + +++ + +++A+ + M +T + R+L + ++ ++++ W N
Sbjct: 1262 -VDEKRQVFHALEDELQKAKAISDEMFKTYKE-RDLDFDWHKEKA--DQLVERWQ---NV 1314
Query: 629 VASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ 688
+ L D E + +S +D + L WIQQ + ++ L Q
Sbjct: 1315 HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ 1373
Query: 689 QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT----DCVVTLSAFATEAHKKLSEPLEV 744
Q +L++ +E+KQ ++ DE + ++Y+ D + + + P++
Sbjct: 1374 QKMLVSE------IEMKQ-SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR 1426
Query: 745 SFM--NVKLLIQDLEDIEQR----VPVMDAQYKIITKTAHLITKE--SPQEEGKEMFATM 796
M + L+IQ+ D+ R V +M K + + +E S +EE KE
Sbjct: 1427 RRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA 1486
Query: 797 SKLKEQLTKV-----------KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEII 845
+L++ ++ + K +S S+++ E+L + + + L K + +
Sbjct: 1487 KELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKM 1546
Query: 846 TVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ---- 901
T ER + + L E+ K+ G V++ + ++ ++
Sbjct: 1547 TDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGI 1606
Query: 902 ----TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
T+ + ++ AF + T + KK+ L K + S L +V++ + L
Sbjct: 1607 CDLLTQTENRLIGHQEAFM-IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1665
Query: 958 EEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD 1017
+E G+ + E + ++Q++ A +K C++L ++ EQ ++ L + V
Sbjct: 1666 KENGE-----KLSQEDKALIEQKLNEAKIK-CEQL-NLKAEQSKKELDKVVTTA------ 1712
Query: 1018 LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP--QEGSEKIIKEHRVFFSDK 1075
+K + EK + +EE +T+++ + + SE+ +H+
Sbjct: 1713 -----------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1761
Query: 1076 GPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD 1135
G H I E D V ++ ++ + +T L + K K
Sbjct: 1762 GTHFQEGDGKSAIGE-------EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVK- 1808
Query: 1136 YTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRL 1195
++ IS ++ + + + G+ E+ E L L
Sbjct: 1809 -----AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEK---------EKLQKNMKEL 1854
Query: 1196 KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
KV E + LA+ K +L E+EK +++ + + + + LE L
Sbjct: 1855 KVHYETA-----------LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 1903
Query: 1256 ISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD 1315
+G+ ++ K+ ++ E ++ H+ + I+ V + + +GG D
Sbjct: 1904 EAGADDINGLMTKLKRQKSFSED---VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1960
Query: 1316 RG--HEEL-RKLESTLDGLERSRERQE---RRIQVTLRKWERFETNKETVVRYLFQTGSS 1369
H E+ RKL+ D + ++ + K++ +E ++ L ++
Sbjct: 1961 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2020
Query: 1370 HERFLS---FSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL---- 1422
+ LS ++L +LE+TK + S V E L K+ +E+ L + L
Sbjct: 2021 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL-KKTAEVLLDARGSLLPAKN 2079
Query: 1423 ------------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470
+ +KS+ E+ +KL+ TL + + + D G+ +
Sbjct: 2080 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN--------VE 2131
Query: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530
KE + +S+A+ IS+ + Q+I + SSI + E+ + F + ++ ++
Sbjct: 2132 SSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQ 2191
Query: 1531 AKLTQI-RRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI- 1588
AK+ + R+ E +H + L + L + + ENL + Q+ E + + + +
Sbjct: 2192 AKMKDLSARFSEASHKHKETL--AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2249
Query: 1589 CSSATETYKVLQ-------EHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ 1641
TE + +Q EH + L SL I++ + K + + + +
Sbjct: 2250 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNNLSKKFK 2308
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA------- 1694
+ ED ++ KE T+ + L +Q L K L S W++ K + A
Sbjct: 2309 EMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAEDLGKSL 2365
Query: 1695 -DRVKVEGELQL----IQALQNEVVSQASFYSKLLQLKESLFSVAS-------------- 1735
D K++ + L IQ + N +S + S + +++ +V S
Sbjct: 2366 EDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNT 2425
Query: 1736 -----KDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
+ +K + + + DL ++ +I L + +++ Q+ E + W+
Sbjct: 2426 EEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQK 2485
Query: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED- 1845
K QT + + + ++K AE++ ++Q L+ L +L L D
Sbjct: 2486 MNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL--LEENPDT 2543
Query: 1846 ---------LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGIL--RQL 1894
L + K ++ QL + Q +E + ++L +F A L L ++L
Sbjct: 2544 PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEE---SSNNLTQFQTVEAQLKQWLVEKEL 2600
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQ----NAKALESAAVSLDGILSKAQYHLKIGSSE 1950
+V S++ N + + + LQ E + GILS+ E
Sbjct: 2601 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--------PGE 2652
Query: 1951 QRTSCRATADQLCGEVERIQNLLGTKQSEADAL--AVLKKA-FQDQKEELLKSIEDIEER 2007
+ +QL ++ +L G D + A++K +Q L + D++ +
Sbjct: 2653 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2712
Query: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ--KDVAFAPEVDR 2065
A+ Q+L +++ E+ + ++ + + ++ K+ E+ R
Sbjct: 2713 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2772
Query: 2066 EINRLEVTWDDTKRL----IHENQGQCC-------------GLIDLMREYQNLKSAVSKV 2108
++ + ++ D ++ + Q C +D +E QN +S
Sbjct: 2773 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2832
Query: 2109 LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS 2168
L+ V + IKD +D FSK TA++ M K ++G++L L K
Sbjct: 2833 LD------VLESLIKDHKD----FSKTLTAQSHMYEKT------IAEGENL---LLKTQG 2873
Query: 2169 SDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL-----------SIW----------D 2207
S+ + ++ + + W +++++E ++L+ SL ++W +
Sbjct: 2874 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2933
Query: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK----------EFESEV---KNK 2254
++ D EG N + ++ +D H ELL E + EV +NK
Sbjct: 2934 EIKFCLDPAEG--ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2991
Query: 2255 AL------RLEELHSKVNDLKELTKNL--------ETPPDLQFIEADL------------ 2288
+L E+LHSK L+ +T+ E+ LQ + L
Sbjct: 2992 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3051
Query: 2289 ----------MQKLEHAKEITEVAKGTLKDFTAQST----------QVEKFINDITTWFT 2328
+ L+ K ++AK +D +++ QVE + +T
Sbjct: 3052 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3111
Query: 2329 KVEESL---------MNCAQNETCEALKKVKDIQKE-------------LQSQQSNIS-- 2364
+V+E + QN E + + E LQ Q+ I
Sbjct: 3112 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF 3171
Query: 2365 --------STQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK 2416
++ +N N C+ + E S + G+ + EA+S+ C+K Q + E+
Sbjct: 3172 LKKLEALMASNDNANKTCKMMLATEETS--PDLVGIKRDLEALSKQCNKLLDRAQ-AREE 3228
Query: 2417 HFSESMQEFQEWFLGAK------AAAKESSDRTGDSKVLEAKLHDLQNIL-----DSVSD 2465
+++ +E++ K A+E + G + ++ N+ + +
Sbjct: 3229 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3288
Query: 2466 GQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQALQDCASEL 2524
Q K V GQ L +K ++ + N ++ K+ + LQ+
Sbjct: 3289 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3348
Query: 2525 GSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES-LDK 2583
G F+D L W+ + EE + ++ + + + + K+ L LL R+S ++
Sbjct: 3349 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL---LQRLLDDRKSTVEV 3405
Query: 2584 LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ------VALQEHEALE 2637
+ + G+ ++ A + L L + + K + R+ Q VA Q HE LE
Sbjct: 3406 IKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3465
Query: 2638 EALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ---IQDILLMKGEGEVKLNMAIGK 2694
+ W+ I+ RL E LE++++Q ++D ++ + L+ A+
Sbjct: 3466 PLNE----WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK---HLHQAVSI 3518
Query: 2695 GEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2754
G+ S++E + ++Q++L+ + + +I S L+ + + E + +L
Sbjct: 3519 GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3578
Query: 2755 WMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK---T 2811
W+ V K+ K + D+ L + + R L I ++ ++
Sbjct: 3579 WLNEVHDKL-----------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3627
Query: 2812 EDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELH 2871
E K T +E+ D + K + + + ++ D L+ + LHS EEL
Sbjct: 3628 GLELLKQTTGDEVLI-IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3686
Query: 2872 RWSD-------------MSGDSSA--------TQKKLSKIKELIDS-REIGASRLSRVES 2909
W D + G+ ++ +K+ K L+DS E+ ++ L V
Sbjct: 3687 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3746
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA-LSEQE---F 2965
A E + A E + ++ + ++ ++Q + ++++ ++E E
Sbjct: 3747 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3806
Query: 2966 SGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR 3022
S +LEQ +Q SA L KT+ + +L K+ +++V+ HK I+ A +E
Sbjct: 3807 SLGDIRLEQ--DQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHK---IMTAC--SEEE 3857
Query: 3023 TEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLC-LQASKGCQ-NKEQILQQRFRKAF 3080
+ +K +L++ ++K Y+ +C + + + Q + Q L +F + +
Sbjct: 3858 KQSMKKKLDK-----------------VLKNYDTICQINSERYLQLERAQSLVNQFWETY 3900
Query: 3081 RDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF--LSE--SENGQHKLNMMLSKGE 3136
+ WL T + +P E T Q+ +E L E +E+ H M + +
Sbjct: 3901 EELWPWLTE---TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3957
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
LL L+ + IQ K AA + ++ ++ AL+ Q F + I + L
Sbjct: 3958 LLE--LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4015
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL------WEG 3250
+ + + + + ++ + + + ++V ++ +P LK++ +++ +
Sbjct: 4016 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4075
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKEKVSRL-------DRIVAEHNQFSLGIKELQDWM 3303
++K+ + ++ Q+ + + L +E+ ++L ++ +H + IK+ QD++
Sbjct: 4076 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4135
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
D P D SV+ + E + + ++ +++ G ++
Sbjct: 4136 RDLE-------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDK 4188
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
P +++ + + W SL A +LE A+ YQDG++ W+D L
Sbjct: 4189 PIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS 4248
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIE-------VKGAGMTEHYVTQLELQDL 3476
+L + + K E +E + K ++ + Q L +L
Sbjct: 4249 PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMEL 4308
Query: 3477 QERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHE 3536
+ + +++ER K E + ++Q L WL + L + + GD E
Sbjct: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368
Query: 3537 TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALESLRQDWQAYQHRL 3593
L LQ Q+ + +V D+I S + LE L Q WQ +
Sbjct: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
Query: 3594 SETRTQFNNVVNKLRLMEQKFQQVDEWL-----------------KTAEEK-KWHEEVTA 3635
+ + Q + + + + + + + +WL +TA+E+ H EV A
Sbjct: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4488
Query: 3636 YRDEVEE----VGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3689
+ EE + + Q++L + + L +++++ ++ E+ LEE +
Sbjct: 4489 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4548
Query: 3690 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV-DTVMMGKKLKTLEVLLKDMEKGHSL 3748
E +SL + +W + NVA++ + DTV+ ++ +V ++
Sbjct: 4549 NLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF--QIDEHKVFANEVNSHREQ 4605
Query: 3749 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3808
+ + G + ++ + ++ + + +++ + + +L+ AK+F +
Sbjct: 4606 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4665
Query: 3809 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3868
L +W+ E ++ L E + + K QL+++K Q+++ + + G +L
Sbjct: 4666 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725
Query: 3869 LELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3928
E +L D D L+ D D L+ L+ K DT+ G+ + Q
Sbjct: 4726 KE---KTSLAD--DNLKLD-------------------DMLSELRDKWDTICGKSVER-Q 4760
Query: 3929 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 3988
KL++ + Q T D+ A+ R+ L + H D + A Q +L
Sbjct: 4761 NKLEEALLFSGQFT-DALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKEL 4818
Query: 3989 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLD--------LLCSMCDLSNASVKTTAKDI 4040
K+ +AL+ AR ++ + M +LS A I
Sbjct: 4819 G-------------KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4865
Query: 4041 QQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL--ELNIAQ 4098
+ + +E L QA EE + L +L +A+Q L R H L + + +
Sbjct: 4866 SK-QTRLEAALRQA-------EEFHSVVHALLEWLAEAEQTL----RFHGVLPDDEDALR 4913
Query: 4099 NMVSQVKDFVKKLQSKQASVN 4119
++ Q K+F+KKL+ K+A +N
Sbjct: 4914 TLIDQHKEFMKKLEEKRAELN 4934
Score = 264 bits (674), Expect = 3e-69
Identities = 856/4706 (18%), Positives = 1829/4706 (38%), Gaps = 694/4706 (14%)
Query: 2615 LLRMTKEKLRSCQVA--LQEHEALEEALQSMWFWVKAIQ---DR------LACAESTLGS 2663
L+++ K L+S + L E E + +Q + WV +Q DR L ES L +
Sbjct: 621 LMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN 680
Query: 2664 KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723
+ + + + + L E+++ + + +L L+ +A
Sbjct: 681 HKNVHRAIEEFESSLKEAKISEIQMTAPL--------------KLTYAEKLHRLESQYAK 726
Query: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWM-ESVDQKIEHPLQPQ-PGLKEKFVLLD 2781
++++S + + L+++ +++V R W+ E ++++ + + + K
Sbjct: 727 LLNTSRNQERHLDTL----HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 782
Query: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841
L L + E++ +++ + + L E + + ++TQ++ I+ + +
Sbjct: 783 ELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQTQWSWILQLCQ----C 836
Query: 2842 VEEIVKDHLMYLDAVH---EFTDWLHSAKEELHRWSDMSGDSSA------TQKKLSKIKE 2892
VE+ +K++ Y + + E TD+L + K+ + R SS Q+ + + +E
Sbjct: 837 VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 896
Query: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC-L 2951
L+ + A+ + + +++ +N S C L + D++Q E ++++ C L
Sbjct: 897 LLQYKSTIANLMGKAKTIIQLKPRN---SDCPLKTSIPIKAICDYRQIEITIYKDDECVL 953
Query: 2952 ENLVSQMALSEQEFSGQVAQL-----------EQALEQFSALLKTWAQQLTLLEGKNTDE 3000
N + +G A + ++A++ + + + + LTL + +
Sbjct: 954 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 1013
Query: 3001 EIVECWHKGQEILDALQKAEPRT-------------EDLKSQLNELCRFSRDLSTYSGK- 3046
+ V WH +D ++ + + +L+S+ + S++ +SG
Sbjct: 1014 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1073
Query: 3047 VSGLIKEYNCLCLQ------ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDI 3100
++ L KE N +C Q S + +E+ + + R+ + L N + +
Sbjct: 1074 ITQLEKEVN-VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1132
Query: 3101 PQNISEVSTSLQKIQE---FLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTA 3156
P ++ S+ +I E E E + L + +K E S +++++
Sbjct: 1133 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1192
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT--EKMVHESSNRLYDLP 3214
++ +S L+ + + +K+ + + ++ + +K E+ V N + +L
Sbjct: 1193 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1252
Query: 3215 AKRRE-QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN 3273
+ ++ + ++ + H E +L + K + +++ K+++ R
Sbjct: 1253 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF------KTYKERDLDFDWH------ 1300
Query: 3274 LTKEKVSRL-DRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3332
KEK +L +R H Q +++L+ + D+Y HP D
Sbjct: 1301 --KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY-HPLDDW------------ 1345
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3392
++Q + Q K +Q PE T+ QL K +L + I K
Sbjct: 1346 ---IQQVETTQRK---------IQENQPENSKTLATQLNQQK-----MLVSEIEMKQSKM 1388
Query: 3393 GALSKWTS-YQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS--- 3448
K+ Y V+ + + A ++ ++ + R M A L+ +E +
Sbjct: 1389 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR---RMQSSADLIIQEFMDLRT 1445
Query: 3449 -YSSL--LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505
Y++L L T +K AG + L+ L+E ++++E KE V K+++L +
Sbjct: 1446 RYTALVTLMTQYIKFAGDS--------LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1497
Query: 3506 RDLKAFEV---------------------WLGQEQEKLDQYSVLEGDAHTHETTLRDLQE 3544
+ LK E L + + + + GD T E ++
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557
Query: 3545 LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN-- 3602
++ L + L ++ SG + E++ + +Q+++ + + TQ N
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1617
Query: 3603 -------VVNKLRLMEQKFQQVDEWLKT---------AEEKKWHEEVTAYRDEVEEVGAR 3646
++ + +K+Q E L+ AE K E ++ E++
Sbjct: 1618 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL--KENGEKLSQE 1675
Query: 3647 AQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE-----IQSLEESESSLSS 3701
+ ++++ +++ C+ L + L + EE ++ LEES++ + +
Sbjct: 1676 DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIEN 1735
Query: 3702 YSDWYGSTHKNFKNVATKIDKV----------------------------DTVMMGKKLK 3733
DW + K+ + TK +V +T + G+
Sbjct: 1736 LLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGT 1795
Query: 3734 TLEVLLKDMEKGHS--------------LLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
T E L + +K + +SA+ E+ +YL E E+L+K +M
Sbjct: 1796 TQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----NM 1851
Query: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
++LK T E EK + L ++ L ++ A+Y E H ++ + EL +A
Sbjct: 1852 KELKVHYETALAES---EKKMKLTHSLQEE---LEKFDADYTEFEHWLQQSEQELENLEA 1905
Query: 3840 ----------QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQ 3889
+L + KS + V+SH+ ++ + G +LE + + +D
Sbjct: 1906 GADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD------GGKV 1959
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
D + + + ++ DR +L K + L D + + H + A
Sbjct: 1960 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK------YQHYE------DAS 2007
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4009
C + Q+ E KH+S + +Q LE + + + Q
Sbjct: 2008 CGLLAGL-QACEATASKHLSEPIAVDP-----KNLQRQLE---ETKALQGQISSQQVAVE 2058
Query: 4010 ALQEQARTYLDLLCSMCDLSNASVKTT----------AKDIQQTEQTIEQKLVQAQNLTQ 4059
L++ A LD S+ N KT +K + + + ++ L ++ ++
Sbjct: 2059 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2118
Query: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119
G +E+ + L++ Q L Q+++S+ + + +Q+S+N
Sbjct: 2119 GLDEMLDWMGNVESSLKEQGQV---------PLNSTALQDIISKNIMLEQDIAGRQSSIN 2169
Query: 4120 TIIEKVNKLTKKEE----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
+ EKV K + + S ++ L+ ++ + + + EE + + +
Sbjct: 2170 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2229
Query: 4176 NVVEVFLEKFT---TEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232
++ FLE T TE D + E + E+ + E K +E L +++
Sbjct: 2230 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL----EHKKHLEVLHSLLKEIS 2285
Query: 4233 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4292
H DK LV E+T++L +++ ++ED IK K + + E+L+ Q + L W +E
Sbjct: 2286 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2345
Query: 4293 -------QPNI-AEAL------------KQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
QP+ AE L K S Q + +++C+ + A K+
Sbjct: 2346 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2405
Query: 4333 L--IKDADRVM-------------ADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4377
+ +K V+ A+ GL I+K ++D L L+ + L
Sbjct: 2406 IAAVKSGGAVLNGEGTATNTEEFWANKGLTS---IKKDMTDISHGYEDLGLLLKDKIAEL 2462
Query: 4378 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD---VSKQVKTCKSAQASLKT 4434
N LS K Q A Q Q K + P D V QV+ KS +A LK
Sbjct: 2463 NTKLS-KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2521
Query: 4435 YQNEVTGLWAQGRELMKEVTE-QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493
N+V L + EL++E + E L E+ S + + Q R Q+LE++ +
Sbjct: 2522 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2581
Query: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ----SPEYENLLL 4549
F+ + WL + +++ L + + L+TQ + Q +L++ P+YE L
Sbjct: 2582 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2641
Query: 4550 T----LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4605
L R G+ PSL + + E+L A+ ++++ + D+ + +AI+ +Y
Sbjct: 2642 AGQGILSRPGED--PSLRGI----VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQY 2695
Query: 4606 ASLIELTTQSLSELEAQFLRMSKVPT-----DLAVEEALSLQDGCRAILDEVAGLGEAVD 4660
SL+ + LS+L+ + V T + +E A ++ + ++ +
Sbjct: 2696 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2755
Query: 4661 ELNQ-KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
+L+ KE + Q + +L + ++++ E V L+ ++ + ++M +
Sbjct: 2756 DLSALVKEEYLKAELSRQLEGIL---KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF 2812
Query: 4720 ERQLKSVKEEQSK---VNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD 4776
+ L + KEEQ+K ++ + E +K + + +L + ++ E+L L
Sbjct: 2813 QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL--LK 2870
Query: 4777 PLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID----FQTEMSRSLDWLRRV 4832
EKA Q+Q +K + V E E+++ +S++ ++ ++ W+ +
Sbjct: 2871 TQGSEKAALQLQ--LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2928
Query: 4833 KAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA---KELIS 4889
+ L + L+ + + I K++ Q+E+ ++ L++ + KE+++
Sbjct: 2929 QNNLE-EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2987
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 4949
D SL + ++ + E L +++ L + + + + +V + + L+ A+E L +
Sbjct: 2988 -DENKSLIQKVDM---VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH- 3042
Query: 4950 NGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL--DPLIKPT---GKEDLEQKV 5004
D ++ ++ T+ + L+ L L D +++ + G D+ +V
Sbjct: 3043 ---DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQV 3099
Query: 5005 ASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS 5064
++ +S+ + L+ +Q E+ + + +L + + +
Sbjct: 3100 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA- 3158
Query: 5065 HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ-------LEKTGNDASKATLSRSMTTV 5117
E L + K + E ++A + A++ E+T D + R + +
Sbjct: 3159 ----ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL--VGIKRDLEAL 3212
Query: 5118 WQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELL 5177
++ +L AQ +E+ +E + F +K+K+ + ++ + ++ ++ E
Sbjct: 3213 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGMETE 3269
Query: 5178 TLLEYHDTF-VLELEQQQSALGMLRQQTLSMLQDG---AAPTPGEEPPLMQEITAMQDRC 5233
T+ + + F V + E+ + G +QQ ++ L G +A L ++ + R
Sbjct: 3270 TINQQLNMFKVFQKEEIEPLQG--KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3327
Query: 5234 LNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIE---IDAQLE 5287
+ +KV +++ L + + S+ W+ +T+E + N P+ E + AQ++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3387
Query: 5288 ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVA-LDLK---IRDQIQ 5343
E Q LL + R++ ++ + + EK T P++ L +++ LD + + ++ +
Sbjct: 3388 E-QKLLQRLLDDRKSTVEVIKREGEKI--ATTAEPADKVKILKQLSLLDSRWEALLNKAE 3444
Query: 5344 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKL------KAKTDNVVQAKTDQKVLGEE 5397
+ +++E +Q+ ++ L + LTTI +L + + + K L ++
Sbjct: 3445 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3504
Query: 5398 LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ-AENRLSKLNQAAS 5456
+ N L + + Q + + K + + +++ I++ + +R L QA
Sbjct: 3505 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC 3564
Query: 5457 HLEEYNEMLELILKW-------IEKAKVLAHGTIA-WNSASQLREQYILHQTLLEESKEI 5508
+ + + E ++ W + K V + T W S+LR +L + +L + +
Sbjct: 3565 NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNV 3621
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEA 5568
D L E L+ T +V + + E ++ K + D AK +++
Sbjct: 3622 DQALLNGLELLKQTT--------GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3673
Query: 5569 ELKKLQAALEQAQATLTSPEVGRLSLKEQL----------SHRQHLLSEMESLKPKVQAV 5618
++L + E+ L EV LS + Q+ + L E ++ K + ++
Sbjct: 3674 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3733
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM-- 5676
SAL A L E + T Q+ + AA+++ +Q++Q
Sbjct: 3734 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADA 3793
Query: 5677 ---------KHLQQLIEGAHREIEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQIAS 5726
K L L G R +D+ A +Q+ +I RH+++ + +I +
Sbjct: 3794 ELSWITETEKKLMSL--GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3851
Query: 5727 LNSKCKMLTMKAK--------------HATMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 5772
S+ + +MK K ++ L + + L + EL P +
Sbjct: 3852 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3911
Query: 5773 SVVMMTAGRC------------HTLL-------SPVTEESGEEGTNSEISSPP---ACRS 5810
S++ H L P ++ + G SP + +
Sbjct: 3912 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE 3971
Query: 5811 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLE-----PSATAK 5865
A+T S ++ +A++ + + + + H E E +E PS +A+
Sbjct: 3972 KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE 4031
Query: 5866 LGDLQRSWETLKNVI--SEKQRTLYEALERQ-----------------QKYQDSL----- 5901
+ ++ KNV EK + LYE L+++ + QD L
Sbjct: 4032 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4091
Query: 5902 --QSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
++I T +E E KL + E E +H +L+ I QD I +L
Sbjct: 4092 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIKDTQDFIRDL---------- 4138
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN--DQLEEQRQEQALQRY 6017
E DP S + E TIR + G ++ L+ +N +L E
Sbjct: 4139 EDPGIDP-------SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4191
Query: 6018 RCEADELDS-WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE----IEQKVVALSEL 6072
+ DEL+S W KA D + +E M Q D + + K+ ++S +
Sbjct: 4192 KKSIDELNSAWDSLNKAWKD-RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4250
Query: 6073 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6132
E + K + E+L +E++R H +L ++ +E ++
Sbjct: 4251 GTDLETV--------KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT-- 4300
Query: 6133 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 6192
VQ+ L + + W + + +Q +LE L + G+ QH+
Sbjct: 4301 --------VQDPLMELKLIWDSLEERIINRQHKLEGAL----------LALGQ---FQHA 4339
Query: 6193 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQN--VLEQEQ 6250
E +LS++ + G+ + E ++ K +LQN + Q
Sbjct: 4340 LDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL------------AKHHVLQNDVLAHQST 4387
Query: 6251 EQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIH 6307
+ + N L+ ++ S + + L+ LNQ ++ V ++ K+Q ++
Sbjct: 4388 VEAVNKAGNDLIE-------SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4440
Query: 6308 LEQKLYDGVSATSTWLDDVEERLFVATAL--LPEETETCL-FNQEILAK-DIKEMSEE-- 6361
+ + + WL D E L + L LPE + L + E+ A + KE + +
Sbjct: 4441 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4500
Query: 6362 MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6421
M K + + ++ P++ + I+ + L + +++ +N+R +++E L + F N
Sbjct: 4501 MQKGQQMLARC-PKSAETN--IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4557
Query: 6422 LKVLFTSLADNKYIILQKLANVFEQP------VAEQIEAIQQAEDGLKEFDAGIIELKRR 6475
L+ L ++ NV +P V QI+ + + + IIEL +
Sbjct: 4558 LQDFINWLTQ-----AEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
Query: 6476 GDKLQVEQPSMQE------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6529
G L+ L +Q +++++ + R L+ Q+ A L +
Sbjct: 4613 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4672
Query: 6530 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ--- 6586
LE EK + I + ++I+ L +HKE+ + L + + +T R S +
Sbjct: 4673 WLEE-SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731
Query: 6587 -----KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6641
K +EL + + ++ +R +LE L + Q L L VE +
Sbjct: 4732 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4791
Query: 6642 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQL 6698
V + D +++ I ++ + L + + Q L R LI S D ++ Q+
Sbjct: 4792 AEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELIEGSRDDSSWVKVQM 4850
Query: 6699 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 6758
+L W + + RLE L+ + S L+ WL A+ L F +P
Sbjct: 4851 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRF----HGVLP 4906
Query: 6759 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT-ATLRSELSRIDSQW 6817
+ + +R ++ EF K+++ + + + + G+ +L + D+ T++ ++ I +++
Sbjct: 4907 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARF 4966
Query: 6818 TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-QKDEDNIKNSIGYKAIH 6876
++L Q++L + + + +++W+ E + KD++ I I + +
Sbjct: 4967 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI--EEVK 5024
Query: 6877 EYLQKYKGFKIDINCKQLTVDFVNQS 6902
+ +++ F ++ KQ VD V ++
Sbjct: 5025 ALIAEHQTFMEEMTRKQPDVDKVTKT 5050
Score = 245 bits (626), Expect = 1e-63
Identities = 593/3347 (17%), Positives = 1290/3347 (38%), Gaps = 356/3347 (10%)
Query: 544 EQLLQNYVSF-IENSKFFEQYEVTYQILKQTAEMYVKADG---SVEEAENVMKFMNETTA 599
E L Q Y ++ K Q++ I Q+A++ ++ G S EE E + K M E
Sbjct: 1798 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856
Query: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH 659
+ E + + +++ + WL+ +E+ L E D +
Sbjct: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916
Query: 660 WIQQHTAMND-------------AGNFLIETCDEMVSRD------------LKQQLLLLN 694
+Q + D +GN ++E RD ++++L
Sbjct: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1976
Query: 695 GRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNV 749
R+R L+ + D+ + + L A A K LSEP+ V N+
Sbjct: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2036
Query: 750 KLLIQDLEDIEQRVPVMDAQYKIITKTAHLI---------------------------TK 782
+ +++ + ++ ++ + + KTA ++
Sbjct: 2037 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2096
Query: 783 ESPQEEGKEMFATMSK-------LKEQLTKVKECYSPLLYESQQLLIPLEE--------- 826
+S E +++ T+++ L E L + S L + Q +PL
Sbjct: 2097 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ---VPLNSTALQDIISK 2153
Query: 827 ---LEKQMTSFYDSLGKINEII-------------TVLEREAQSSALFKQ---KHQELLA 867
LE+ + S+ +NE + ++ + SA F + KH+E LA
Sbjct: 2154 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2213
Query: 868 CQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWK 926
E K + L E S+ +Q F+ T + L D + + ++ Q + + K
Sbjct: 2214 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP--GKDVTELSQYMQESTSEFLEHK 2271
Query: 927 KHVETNSRLMKKF------EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQ- 979
KH+E L+K+ + LEK ++++ E + +E T QLD
Sbjct: 2272 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2331
Query: 980 RVLNAFLKA-CDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRF 1038
+VL LK+ E T +P + E + K + K LQ + ++
Sbjct: 2332 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2391
Query: 1039 LASVEECRTELDRETKLMPQEGS----EKIIKEHRVFFSDKGPHHLCEKRLQL---IEEL 1091
L ++ T + + G+ E F+++KG + + + E+L
Sbjct: 2392 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2451
Query: 1092 CVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1151
+ L + +T + +E +A+ +K+ + KW+ + + + T
Sbjct: 2452 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD--TEAVKTQV 2509
Query: 1152 TQLKGIKGEAIDTANH-GEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQ 1210
Q K + E N E+K + E+ E W ++LTE+ S+ + Q
Sbjct: 2510 EQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW----KQMLTEIDSKWQELNQ 2565
Query: 1211 --GDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEK 1268
D KL S L T VE L + + KE++ + L L + Q ++
Sbjct: 2566 LTIDRQQKLEESSNNL-TQFQTVEAQLKQW---LVEKELMVSVLGPLSIDPNMLNTQRQQ 2621
Query: 1269 ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD-----RG--HEEL 1321
+ Q+LL A ++ +Q+ A QG P RG E+L
Sbjct: 2622 V----------QILLQE-------FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2664
Query: 1322 RKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL-- 1379
+ D L + I + K T ++++R L S + LS SSL
Sbjct: 2665 AAVTQKWDSLTGQLSDRCDWIDQAIVK----STQYQSLLRSLSDKLSDLDNKLS-SSLAV 2719
Query: 1380 ----ESLSSELEQTKEFSKRTESIAVQ---AENLVKEASEIPLGPQNKQLLQQQAKSIKE 1432
++++ +LE ++ + + Q A+ L ++ S + K L +Q + I +
Sbjct: 2720 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2779
Query: 1433 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1492
K +E E ++ ++ F W+ K++E N S+ +D+ S
Sbjct: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2839
Query: 1493 IKVTIQEIESKLSSIVGLEE----EAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQ 1548
IK ++ L++ + E E ++ E A ++ +L I+ + + +
Sbjct: 2840 IK-DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVK 2898
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATE------TYKVLQEH 1602
E + L + K++E + + + + ++ L IK C E K LQ+
Sbjct: 2899 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKLKSLQKE 2957
Query: 1603 MDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLA 1662
MD + L + TA S + ++++ E +L Q+ + + + ++ LEN+
Sbjct: 2958 MDQHFGMVELLNN-TANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQ 3016
Query: 1663 HWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK 1722
++ ++ +K S ++ + +++ + L QA N+ ++ K
Sbjct: 3017 KFKEFQE------------VSKESKRQLQCAKEQLDIHDSLG-SQAYSNKYLTMLQTQQK 3063
Query: 1723 LLQ------------LKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSV 1770
LQ ++ + + + L +E + + L Q ++++ +FL++
Sbjct: 3064 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3123
Query: 1771 VAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSL 1830
+ F + F EL + + + + A T K + E+ K L+ L
Sbjct: 3124 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVG----RDAETLQK----QKETIKAFLKKL 3175
Query: 1831 QGHLAKLGSLGRAEDLHL--------LQGKAEDCFQLFEEASQVVERRQL-------ALS 1875
+ +A + + + L L G D L ++ +++++R Q +
Sbjct: 3176 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3235
Query: 1876 HLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDG 1935
L EF S +L++ + E+ + E++ I + LN K ++
Sbjct: 3236 RLEEFYSKLKEFSILLQKAEEHEESQGPVGM-ETETINQQLNMFKVFQKE------EIEP 3288
Query: 1936 ILSKAQYHLKIGSSEQRTSCRATADQ-LCGEVERIQNLLGT-KQSEADALAVLKKA---- 1989
+ K Q +G +++ ++T+ Q L +++ + T + A A L++A
Sbjct: 3289 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3348
Query: 1990 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2047
FQD E LL + D EE ++ + ++ +++ L+ L+ + + +K
Sbjct: 3349 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3408
Query: 2048 KAKQIA-QKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVS 2106
+ ++IA + A ++ ++++ L+ W+ Q G+ + +++ ++
Sbjct: 3409 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3468
Query: 2107 KVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKK 2165
+ L +V I Q L+ ++H+ ++ + K L S G+ L K
Sbjct: 3469 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-----K 3523
Query: 2166 IHSS--DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE--GWSN 2221
+ SS D +V++ ++ + ++++ EK + L+ +L + + DE+E W N
Sbjct: 3524 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLN 3581
Query: 2222 NCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLE----T 2277
++ + +S L + E L + +SE+ + L+ + L K N + L LE T
Sbjct: 3582 ----EVHDKLSKLSVQDYSTEGLWKQQSEL--RVLQEDILLRKQNVDQALLNGLELLKQT 3635
Query: 2278 PPDLQFIEADLMQKL-----EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2332
D I D ++ + + K T+VAK TL+ + ++ ++ TW KVE
Sbjct: 3636 TGDEVLIIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTHEELCTWLDKVEV 3694
Query: 2333 SLMN-----CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGR 2387
L++ E +A + K+++KE ++ ++ + S E ++L E L +
Sbjct: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3754
Query: 2388 AMTGLIKKHEAVSQLCSKTQASLQESL--EKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
+ +++ VS ++ + ++ + F ++ W + D +
Sbjct: 3755 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3814
Query: 2446 SKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQA 2505
A+L + + + +D + + G + S++ S+++++ K + +
Sbjct: 3815 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3874
Query: 2506 FLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2565
+ + L+ S + F + + +L W+ E + + + ++ E H
Sbjct: 3875 ICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEH 3934
Query: 2566 KVEMFLGELLAA-RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLR 2624
+ L EL+A + +DK+++ G L E G EG + + L KE ++
Sbjct: 3935 RQ---LRELIAEHKPHIDKMNKTGPQLLELSPG---EGFSIQEKYVAADTLYSQIKEDVK 3988
Query: 2625 SCQVALQE--------HEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
VAL E H+ +++ L+S+ + I +RL S + +++++S+ ++
Sbjct: 3989 KRAVALDEAISQSTQFHDKIDQILESL----ERIVERLRQPPSISAEVEKIKEQISENKN 4044
Query: 2677 ILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ----RVIQTQLETLKEVWADIMSSSVHAQ 2732
+ + + + +GE+ + S + + +Q +L+ + +W +I + +
Sbjct: 4045 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104
Query: 2733 STLESVISQ----WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
+ L V+ W D++ ++ + + + + P +++ + ++I
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQ----EAAETIRE 4160
Query: 2789 EAEDHTRALHRLIAKSRELYEK--TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIV 2846
E + L +I EL D+ + +EL + ++ + K+++ K+EE +
Sbjct: 4161 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4220
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELID---SREIGASR 2903
+ + Y D + DW+ A +L S + D ++++ ++K+ ++I R
Sbjct: 4221 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4280
Query: 2904 LSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2963
L+ L +K+ T S + + L+ W E+ + Q LE + +
Sbjct: 4281 LNHQAELL--LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL----- 4333
Query: 2964 EFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3023
Q + AL++ A L L+ + D + +E +L A T
Sbjct: 4334 ------GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4387
Query: 3024 -EDLKSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRK 3078
E + N+L S + S K+ L + + + + + Q + L+Q F
Sbjct: 4388 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4447
Query: 3079 AFRDFQQWLVNAK---ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3135
D QQWL + + + + +P+ E L E + E + ++ KG
Sbjct: 4448 EIEDLQQWLTDTERHLLASKPLGGLPETAKE---QLNVHMEVCAAFEAKEETYKSLMQKG 4504
Query: 3136 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3195
+ + K I + KE W++ + L+++++ LE +F S + +W
Sbjct: 4505 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4564
Query: 3196 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL--WEGQAA 3253
L++ E+ ++ +S L + + + E++ + Q+ L + L + +
Sbjct: 4565 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4624
Query: 3254 SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY 3313
++ + + S++ + E+ LD QF +L +W+ ++ LDS
Sbjct: 4625 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4684
Query: 3314 CHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS-PEGIPTIQQQLQS 3372
+D + ++ + + K G S+ + TS + + L
Sbjct: 4685 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4744
Query: 3373 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3432
++D W ++ + +++LE AL + D ++ W+ +E L E + H ++
Sbjct: 4745 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4804
Query: 3433 TTMLGKAKLLNEEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQER 3486
++ K +E+ +S ++ ++ ++G+ +V ++++Q+L R+ +
Sbjct: 4805 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV-KVQMQELSTRWETVCAL 4863
Query: 3487 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3546
+ T+ E +R +E+ + A WL + ++ L + VL D T + +E
Sbjct: 4864 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4923
Query: 3547 VHCAEGQALLNSVLHTREDVI----PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
E +A LN + V+ P I + + +R ++ + + + +
Sbjct: 4924 KKLEEKRAELNKATTMGDTVLAICHPDSITTIK-HWITIIRARFEEVLAWAKQHQQRLAS 4982
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQE 3649
+ L ++ + + WL+ AE ++ E+EEV A E
Sbjct: 4983 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5029
Score = 239 bits (611), Expect = 7e-62
Identities = 867/4747 (18%), Positives = 1760/4747 (37%), Gaps = 818/4747 (17%)
Query: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2242
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 631 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 686
Query: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2299
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 687 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 732
Query: 2300 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2355
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 733 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 787
Query: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 788 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 838
Query: 2416 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2463
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 839 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 897
Query: 2464 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2502
+S + + + +T+ + +I ++ AN
Sbjct: 898 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 957
Query: 2503 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2542
+A K C ++ E Q++ L LW HE
Sbjct: 958 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1016
Query: 2543 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2592
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 1017 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1070
Query: 2593 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1071 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1123
Query: 2652 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2702
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1124 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1182
Query: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2762
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1183 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1237
Query: 2763 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2821
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1238 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1293
Query: 2822 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1294 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1353
Query: 2871 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2929
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1354 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1411
Query: 2930 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2989
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1412 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1457
Query: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1458 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1498
Query: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1499 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1552
Query: 3110 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3156
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1553 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1612
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3210
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1613 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1672
Query: 3211 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3258
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1673 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1727
Query: 3259 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3308
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1728 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1787
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3363
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1844
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1845 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1904
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3465
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1905 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1964
Query: 3466 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3518
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024
Query: 3519 ------------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALL----NSVLHT 3562
Q +L++ L+G + + + L++ + + L N + T
Sbjct: 2025 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2084
Query: 3563 REDVI------PSGIPQAEDRALESLRQ------------DWQA-------YQHRLSETR 3597
+D++ + + ++ +L + DW Q ++
Sbjct: 2085 LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNS 2144
Query: 3598 TQFNNVVNKLRLMEQ-------KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEI 3650
T ++++K ++EQ ++E +K E ++ + +++++ AR E
Sbjct: 2145 TALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE- 2203
Query: 3651 LDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH 3710
SH + + +L ++ +E + L E++Q+ E+++ + D G
Sbjct: 2204 --ASHKHKETLAKMEELKTK--------VELFENLSEKLQTFLETKTQALTEVDVPG--- 2250
Query: 3711 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770
K+ ++ + + + + K K LEVL HSLLK G + K L +
Sbjct: 2251 KDVTELSQYMQESTSEFLEHK-KHLEVL-------HSLLKEISSHGLPSDKALVLEKTNN 2302
Query: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
L K + KE+ T++++ + F K+L WI E + + + +P
Sbjct: 2303 LSK-------KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQP 2354
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK-IDQLQSDYQ 3889
+ L K LQ+ P ++ V G +L L+ VT K I ++S
Sbjct: 2355 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2414
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
L G A E L +++ K T I + L LK +
Sbjct: 2415 VLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI-------------- 2459
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL-----SAVQPDLEPSPQPPLSRAEAIKQ 4004
L +L K Q+ WL +A + P+P + ++Q
Sbjct: 2460 --------AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2511
Query: 4005 VKHFRA-LQEQARTYLDLLCSMCDLSNASVKT-TAKDIQQTEQTIEQKLVQAQNLTQGWE 4062
K F A L++ +L + +L + T A +Q I+ K W+
Sbjct: 2512 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK----------WQ 2561
Query: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELE---------------LNIAQNMVSQVKDF 4107
E+ L + L+++ L + ++L+ L+I NM++ +
Sbjct: 2562 ELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2621
Query: 4108 VKKLQSKQASVNTIIEKVNK-----LTKKEESPE-----HKEINHLNDQWLDLCRQSNNL 4157
V+ L + A+ E++ L++ E P +++ + +W L Q ++
Sbjct: 2622 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2681
Query: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER 4217
C ++ + ++ Y + + +K + + L+ S A ST H +A+ + Q+
Sbjct: 2682 CDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVST--HPDAMNQQLETAQKM 2736
Query: 4218 KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK------RKIQVSVTN 4271
K I+ K Q K+ + L D LVKE+ E QLE ++K +K + V +
Sbjct: 2737 KQEIQQEKKQ-IKVAQALCEDLSALVKEEYLKAELS-RQLEGILKSFKDVEQKAENHVQH 2794
Query: 4272 LEELNVVQSRFQEL----MEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327
L+ +FQ++ W + ++ ++ S D+ ++L+ DH L A+
Sbjct: 2795 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS 2854
Query: 4328 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR----RKYLNKALSE 4383
+ + I + + ++ +E+ +Q L+ +++ + + V +R ++ L KAL
Sbjct: 2855 HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY 2914
Query: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443
K Q + ++ + Q + +I F CL P + + KS Q + + V L
Sbjct: 2915 KEQ-VETLWPWIDKCQNNLEEIKF----CLDPAEGENSIAKLKSLQKEMDQHFGMVELLN 2969
Query: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
L+ V E +K V + + L D V ++ + LE K F+E ++
Sbjct: 2970 NTANSLL-SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3028
Query: 4504 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563
L+ A E ++H L S Y N LT+ +T Q
Sbjct: 3029 KRQLQCA-----------KEQLDIHDSLG--------SQAYSNKYLTMLQTQQ------- 3062
Query: 4564 EVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEA-----ILAR-----KEYASLIELTT 4613
+ L AL Q ++ LA+D + ++ +L + +E+++L +
Sbjct: 3063 --------KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3114
Query: 4614 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR--- 4670
+ S LE + + + E S LD +A +G + L ++KE +
Sbjct: 3115 EKCSFLETKLQGIGHFQN--TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3172
Query: 4671 --------STGQPWQPDKML--------HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK 4714
S + KM+ LV + L+ ++Q LL+ + ++ E
Sbjct: 3173 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3232
Query: 4715 MCQQLERQLKSVK-------------EEQSKVNEETLPAEEKLKMY--------HSLAGS 4753
++LE +K E Q V ET ++L M+ L G
Sbjct: 3233 TIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3292
Query: 4754 LQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMV 4813
QD + + + ++ A E H + K L + + + + ++
Sbjct: 3293 QQDVNWLGQGL---IQSAAKSTSTQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALL 3346
Query: 4814 QSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL 4873
FQ + L W+ + ++ + ++ +I++ ++ Q + + +
Sbjct: 3347 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3406
Query: 4874 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQV 4930
+E EK E AD L +LS LD + L TR L I Q++++
Sbjct: 3407 K-REGEKIATTAE--PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3463
Query: 4931 FQAANDWLEDAQE-LLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 4989
+ N+WL ++ L+ G EE + H + ED ++ + LH V+
Sbjct: 3464 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQ 3520
Query: 4990 PLIKPTGKEDLEQKVASLELRSQ---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5046
L + +ED + + L+ + S ++ +LLQ+ + + E++ +
Sbjct: 3521 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3580
Query: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
N+ KLS+ S ++ S+ ++ SE + L E I+ ++ Q G +
Sbjct: 3581 NEVHDKLSKLS-VQDYSTEGLWKQQSELRVL-------QEDILLRKQNVDQALLNGLELL 3632
Query: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
K T + + + ++A +D K+ D V K E QL +L
Sbjct: 3633 KQTTGDEVLIIQDKLEAIKARYKDITKLSTD-----------VAKTLEQALQLARRL--- 3678
Query: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
++ EL T L+ + +L E Q GEE
Sbjct: 3679 ---HSTHEELCTWLDKVEVELLSYETQ--------------------VLKGEE------- 3708
Query: 5227 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQL 5286
+ + K +K+E K+ + + +N E+ + L
Sbjct: 3709 ----------ASQAQMRPKELKKEAKNNKALLDSLN------------------EVSSAL 3740
Query: 5287 EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKI 5346
EL R+ +EKM E E+Y L S+ Q E +R Q D+
Sbjct: 3741 LEL-----VPWRAREGLEKMVAEDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQA 3790
Query: 5347 KEVEQSKATSQE---LSRQIQKLAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCN 5402
+ E S T E +S +L +D T+ L K T +++ K + ++L
Sbjct: 3791 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSG 3846
Query: 5403 SKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN 5462
K+M + +K + + KK+ K+ + + + R +L +A S + ++
Sbjct: 3847 HKIMTACSEEEK---------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3897
Query: 5463 EMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521
E E + W+ E +++ LR+Q H+ L E E ++ M +
Sbjct: 3898 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3957
Query: 5522 LTSVYCTEKMSQQVAELGRET--EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
L + E S Q + +T ++++ +K R L +A +F ++ ++ +LE+
Sbjct: 3958 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4017
Query: 5580 AQATLTSP-----EVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA- 5633
L P EV + +KEQ+S +++ +ME L+P L ++ + E+++A
Sbjct: 4018 IVERLRQPPSISAEVEK--IKEQISENKNVSVDMEKLQP------LYETLKQRGEEMIAR 4069
Query: 5634 --SLPLCHAALRLQEEASRLQ------HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIE 5684
+A +Q++ ++ HT +++ V++ E++ + L I+
Sbjct: 4070 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4129
Query: 5685 GAH---REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
R++ED + S +++ Q E + ++I G QE++ + + L
Sbjct: 4130 DTQDFIRDLEDPGIDPSVVKQQQ---EAAETIREEIDGLQEELDIVINLGSELIAACGEP 4186
Query: 5742 TMLLTVTEVEGLAEGTEDLD----GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797
+ ++ L + L+ + A + V G + V G+
Sbjct: 4187 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK-- 4243
Query: 5798 TNSEISSPPACRSPSPVANTDASVNQDI---------AYYQALSAERLQTDAAKIHPSTS 5848
S SP+ +V Q I AY Q + ERL H +
Sbjct: 4244 ----------LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN------HQAEL 4287
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
++ E + + L +L+ W++L+ I +Q L AL ++Q +L + +
Sbjct: 4288 LLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4347
Query: 5909 EAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
E LSE G P E ++A+H L +++L Q + E + +L+ S +
Sbjct: 4348 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEE 4406
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ+ L VL +R + K ++Q L+ L RQ + + E ++L
Sbjct: 4407 ASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQ 4453
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL T+ L + P + QL + E K L + +L
Sbjct: 4454 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4513
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQ 6142
+ +Q + LK ++ L++++ ++ A E S D
Sbjct: 4514 SAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI-------- 4562
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE 6202
WL QA T + SL L Q + E K V S E+I+ +
Sbjct: 4563 NWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4621
Query: 6203 KPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL 6262
K DV+ + + ++ +WE + Q + + L + ++ ++ + ++L+
Sbjct: 4622 KQDVVLIK--------NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLM 4671
Query: 6263 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATS 6320
+ + + ++ S L+ N +++ +Q K ++S+ + +YD + T
Sbjct: 4672 EWL--------EESEKSLDSELEIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
L E+T LA D ++ + + + ++ + ++ + +
Sbjct: 4723 --------------RSLKEKTS--------LADDNLKLDDMLSELRDKWDTICGKSVERQ 4760
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ +E+ L G+ + + ++++ +L + D+ ++ + ++K
Sbjct: 4761 NKLEEAL-LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHK------- 4812
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
F++ + ++ ++Q + +E G R D V + MQELS ++ +
Sbjct: 4813 --AFQKELGKRTSSVQALKRSARELIEG-----SRDDSSWV-KVQMQELS---TRWETVC 4861
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHK 6560
+ S+++ L L ++ + L + L ++ + ++ ++ ++ L+D+HK
Sbjct: 4862 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHK 4920
Query: 6561 EYFQGLE 6567
E+ + LE
Sbjct: 4921 EFMKKLE 4927
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 507 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 558
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2454 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2513
Query: 559 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 614
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2514 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2573
Query: 615 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 661
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2574 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2633
Query: 662 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 718
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2634 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2693
Query: 719 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 768
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2694 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2753
Query: 769 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 821
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2754 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2813
Query: 822 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 878
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2814 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2869
Query: 879 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 938
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2870 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2927
Query: 939 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 996
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2928 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2986
Query: 997 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1053
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2987 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3043
Query: 1054 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1113
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3044 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3098
Query: 1114 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1171
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3099 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3158
Query: 1172 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1231
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3159 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3209
Query: 1232 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1272
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3210 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3268
Query: 1273 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1328
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3269 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3327
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1386
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3328 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3386
Query: 1387 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1444
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3387 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3446
Query: 1445 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1501
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3447 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3506
Query: 1502 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1561
+ + QS + + +++KL + + E++E + + L
Sbjct: 3507 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3566
Query: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1614
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3567 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3623
Query: 1615 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1672
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3624 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3683
Query: 1673 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1732
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3684 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3742
Query: 1733 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3743 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3802
Query: 1793 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3803 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3862
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3863 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3921
Query: 1907 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1964
E + + + + Q + + +D + L++ E AD L
Sbjct: 3922 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3981
Query: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2024
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3982 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4038
Query: 2025 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2078
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4097
Query: 2079 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2128
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4098 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4148
Query: 2129 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2184
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4149 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4208
Query: 2185 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2244
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4209 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4264
Query: 2245 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2301
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4265 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4321
Query: 2302 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2356
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4322 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
Query: 2357 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2415
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441
Query: 2416 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4442 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4501
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4561
Query: 2535 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2594
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4562 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4617
Query: 2595 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2650
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4677
Query: 2651 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2709
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4678 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4737
Query: 2710 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2769
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4738 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4797
Query: 2770 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2828
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4798 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4857
Query: 2829 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2888
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4858 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4917
Query: 2889 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2948
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4974
Query: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4975 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5017
Query: 3009 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3054
QEI E++K+ + E F +++ V + K Y
Sbjct: 5018 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5051
Score = 203 bits (517), Expect = 5e-51
Identities = 144/436 (33%), Positives = 219/436 (50%), Gaps = 72/436 (16%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 68 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 125
Query: 80 GRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILY 139
GR R H + N+ AL +L+ R+ +KLVNI + DI DG P + LGL+WTIIL+
Sbjct: 126 GRM--RFHRLQNVQIALDYLKRRQ-------VKLVNIRNDDITDGNPKLTLGLIWTIILH 176
Query: 140 FQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTA 199
FQI ++ V+ E+ +AK+ LL W Q
Sbjct: 177 FQISDIH-------------------VTGESEDM------------SAKERLLLWTQQAT 205
Query: 200 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 259
GI ++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+
Sbjct: 206 EGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGV 264
Query: 260 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 319
RLLDPEDVDV PDEKS++TYV+ +P + +G +++ + + N V
Sbjct: 265 IRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYL 323
Query: 320 KREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHL 375
+ R M ER + L ++Y FK + + K K++ L
Sbjct: 324 IQWIRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKL 377
Query: 376 IQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREE 435
++ G++ L Q ++ +W G + + E ALR E
Sbjct: 378 LEIWIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPE 419
Query: 436 ITVQQVHEETANTIQR 451
+ ++ ++ AN +QR
Sbjct: 420 VERLEMLQQIANRVQR 435
Score = 170 bits (430), Expect = 7e-41
Identities = 619/3344 (18%), Positives = 1264/3344 (37%), Gaps = 595/3344 (17%)
Query: 5604 LLSEMESLKPKVQAVQLCQS-ALRIPED-VVASLPLCHAALRLQEEASRLQHTAIQQCNI 5661
+L ++L+P+V+ +++ Q A R+ D V+ L A LQ ++ RL+ + +Q N
Sbjct: 409 MLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE-SGVQFQNE 467
Query: 5662 MQAA--VVQYEQY-EQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIK 5718
+ A +++ E Q + +Q LI+G + + + +L Q++
Sbjct: 468 AEIAGYILECENLLRQHVIDVQILIDGKYYQAD--------------------QLVQRVA 507
Query: 5719 GYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEG-------------TEDLDGELL 5765
+++I +L ++C + K + T T + G+ + T L L
Sbjct: 508 KLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLT 567
Query: 5766 PTPSAHPSVVMMTAGRCHTLLSPVTE--------------ESGEEGTNSEISSPPACRSP 5811
P+ ++ +++G L VT SG E + + R P
Sbjct: 568 PSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKP 627
Query: 5812 SPVAN------TDASVN----QDIAYY---QALSAERLQ--TDAAKI------HPSTSAS 5850
++ T+ +N QD+ + + +R + +D + H + +
Sbjct: 628 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA 687
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTL---YEAL----ERQQKYQDSLQS 5903
E +E L+ AK+ ++Q + LK +EK L Y L Q+++ D+L +
Sbjct: 688 IEEFESSLKE---AKISEIQMT-APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN 743
Query: 5904 ISTKM--EAIELKLSESPEPGRSPESQMAE-------HQALMDEILMLQDEINELQSSLA 5954
++ E I L E E + H LM E+ ++ I +Q +A
Sbjct: 744 FVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQE-IA 802
Query: 5955 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK------LNDQLEE- 6007
E+L+ E+ A +L +++ + + S I Q ++E ND E
Sbjct: 803 EQLLLENHPA----RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 858
Query: 6008 ---QRQEQALQR-YRC--------------EADELDSWLLSTKATLDTALSPPKEPMDME 6049
+ + A+QR Y C E+ E LL K+T+ + K + ++
Sbjct: 859 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLK 918
Query: 6050 AQLMDCQNMLVEIEQKVVA---LSELSVHNEN-LLLEGKAHT------------------ 6087
+ DC + I K + E++++ ++ +L +H
Sbjct: 919 PRNSDCP-LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 977
Query: 6088 -------KDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ---------EKEESDV 6131
EA LA ++ + ++L L H+ +NM+ S+V
Sbjct: 978 CFTVPPPNKEAVDLANRIEQQYQNVLTLW---HESHINMKSVVSWHYLINEIDRIRASNV 1034
Query: 6132 DLTATQSPGV-QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ 6190
T PG Q+ L+ ++ + + S + Q ++ + + + +E+L
Sbjct: 1035 ASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS 1094
Query: 6191 HSAAETSGDAGEK--PDVLSQELGMEGEKSSAEDQMR--MKWESLHQEFS--TKQKLLQN 6244
E +V + L +E + Q+R ++ + LH+ T+Q+ L+
Sbjct: 1095 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 1154
Query: 6245 VLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 6302
LE+ ++ + + ++ S VPT +S + +L +NQ + S+ K
Sbjct: 1155 ELERLKDDLGTITNKCEEFFSQAAA-SSSVPTL-RSELNVVLQNMNQVYSMSSTYIDKLK 1212
Query: 6303 RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEM 6362
++ L+ A + E +L A++ ++ N E L +K+ E+
Sbjct: 1213 TVNLVLKN-----TQAAEALVKLYETKLCEEEAVIADKN-----NIENLISTLKQWRSEV 1262
Query: 6363 DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQ----QILNF 6418
D+ + +F A + I D + L ++ Q+ ER Q QI N
Sbjct: 1263 DEKRQVF-HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1321
Query: 6419 QNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRG 6476
DL+ + SL KY L + +Q Q + + + K + + K
Sbjct: 1322 LRDLEGIGKSL---KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1378
Query: 6477 DKLQVEQPSMQELSKLQDMYDELMM-----------IIGSRRSGLNQNLTLKSQYERALQ 6525
+++++Q M E K + Y + ++ S++ + ++S + +Q
Sbjct: 1379 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1438
Query: 6526 DLADL---------LETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ DL L T K AGD + +EE + L ++ KE+ +
Sbjct: 1439 EFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEEEKSLEEEKKEHVEKA---------- 1486
Query: 6577 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV 6636
KE Q + ++ S LK A K G +S +E+S + E
Sbjct: 1487 ----------KELQ---KWVSNISKTLKDAEKAGKP------PFSKQKISSEEISTKKEQ 1527
Query: 6637 VESSIPSVGL-VEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLE 6695
+ ++ ++ L + ++ D++ D NE + K + L + LL S S
Sbjct: 1528 LSEALQTIQLFLAKHGDKMTDE---------ERNELE-KQVKTLQESYNLLFSES----- 1572
Query: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6755
L QL E S K+ +++ + + Y+ + + L ++RL Q++
Sbjct: 1573 --LKQLQESQTSGDVKVEEKI-----VAERQQEYKEKLQGICDLLTQTENRL-IGHQEAF 1624
Query: 6756 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATLRSEL 6810
+ ++ + + E K++ + + V+ L+ L + D A + +L
Sbjct: 1625 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1684
Query: 6811 SRIDSQWTDLLTNIPAVQEKLHQLQMDKL-------------------PSRHAISEVMSW 6851
+ + L N+ A Q K ++DK+ S+ I ++ W
Sbjct: 1685 NEAKIKCEQL--NLKAEQSKK---ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1739
Query: 6852 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYK---GFKIDINCKQLTVDFVNQ--SVLQI 6906
+S ++ ++ K I H K G + ++N L D Q + +
Sbjct: 1740 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1799
Query: 6907 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTW 6966
+Q + ++ Q A+ + Q Q L+ ++ Q L E + + N++ LK
Sbjct: 1800 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP--EEKEKLQKNMKELKVH 1857
Query: 6967 FET----QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLAL 7017
+ET EK++K H + ++ +A D + E ++ E+E+E +E NGL
Sbjct: 1858 YETALAESEKKMKLTHSLQEELEKFDA--DYTEFEHWLQQSEQELENLEAGADDINGLMT 1915
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLK---SVLDQWSSHKVAFDKINSY 7074
+++ S V+S +L + + ++ K K +D ++H+ K++
Sbjct: 1916 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD-- 1973
Query: 7075 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 7134
++ RFR L + +NL++L D + E + G + L+ C
Sbjct: 1974 -----HATDRFRSLYSKCNVLG---NNLKDLVDKYQHYEDA--SCGLLAG--LQACEATA 2021
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7194
++ L+ + + + QL+ +KAL + Q+ +L
Sbjct: 2022 SKHLSEPIAVDP-------KNLQRQLEETKAL--------------QGQISSQQVAVEKL 2060
Query: 7195 LKAATNKDIADDEVATWIQDCNDLLKGL----GTVKDSLFFLHELGEQLKQQVDASAASA 7250
K A ++ D + + ND+ K L G +D ++E E+L
Sbjct: 2061 KKTA---EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL----------- 2106
Query: 7251 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL--QGQD 7308
Q++L++ L S+Q G L+ + W+ E L QGQ
Sbjct: 2107 ----QITLTRSL------------SVQDG----------LDEMLDWMGNVESSLKEQGQV 2140
Query: 7309 PSHSSDLSTIQERM----EELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 7364
P +S+ L I + +++ G+ ++M + + E + + K M++L+
Sbjct: 2141 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK-MKDLSA 2199
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7421
+S S + E +K++ + + F EK +T++E +T+ V++ G L
Sbjct: 2200 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE--TKTQALTEVDVPGKDVTELS 2257
Query: 7422 QQRAHELFQ-AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7480
Q + E ++LHS++ + + G D+ K LS +++ +
Sbjct: 2258 QYMQESTSEFLEHKKHLEVLHSLL---KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2314
Query: 7481 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS-----YLPMSGLGSVPIPLQQARTLFDE 7535
++++ + S Q ++ + + L+ W+ E + P G + L+ + L ++
Sbjct: 2315 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2374
Query: 7536 VQFKEKVFLRQQGSYI-------LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM 7588
K + S I K + GA + +E W A+
Sbjct: 2375 WSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW--ANK 2432
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
L KK + + +E + D + +L T KL ++ EE A +++
Sbjct: 2433 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA----QEESSAMMQWLQKMNK 2488
Query: 7649 AVGSW------TD--------------------DLTQLSLLKDTLSAYISAD----DISI 7678
W TD ++ ++ LKD L+ + + +
Sbjct: 2489 TATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPR 2548
Query: 7679 LNERVELLQRQWEELCHQLSLRRQQ-IGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7737
+ + + +W+EL +QL++ RQQ + E N F +L +WL + E VS G
Sbjct: 2549 WKQMLTEIDSKWQEL-NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2607
Query: 7738 ILIE-EMIEKLKKDYQ---EEIAIAQENKIQLQQMGERLAKASHESKASE--IEYKLGKV 7791
+ I+ M+ ++ Q +E A + QL G+ + E + ++ +L V
Sbjct: 2608 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2667
Query: 7792 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI 7851
+W L ++ R + + +V Q + SL L+ ++++L+ + S + + +
Sbjct: 2668 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV-STHPDAM 2726
Query: 7852 QRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD-----------SIQQ 7900
++L Q+++++I++ + LCE L AE ++Q
Sbjct: 2727 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2786
Query: 7901 ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
N + ++ CA S + ++ R +Q +LD K E+ + P S+ +
Sbjct: 2787 KAENHVQHLQSACASSHQ----FQQMSRDFQAWLDT--------KKEEQNKSHPISAKL- 2833
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN 8020
V + +K + F + + E + L + + +L+ ++ WD
Sbjct: 2834 -DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2892
Query: 8021 LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH-FSECDVQAKIKQLK 8079
K+V +LK + + +++ +++ W+ + L I+ + + I +LK
Sbjct: 2893 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLK 2952
Query: 8080 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK- 8138
+ Q+E+ + +E + L+ E +D ++ DE + Q+V E+ H K
Sbjct: 2953 SLQKEMDQHFGMVELLNNTANSLLSVCE-IDKEVVT---DENKSLIQKVDMVTEQLHSKK 3008
Query: 8139 --LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS 8196
L + E +E + + A L HD L Q SN L++ Q +
Sbjct: 3009 FCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDS-----LGSQAYSNKYLTMLQTQQK 3063
Query: 8197 ERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDV 8256
S+ ++ H DL++ L + E D K G SDV
Sbjct: 3064 ---------SLQALK----HQVDLAKRLAQDLV-------VEASDSK--------GTSDV 3095
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR------- 8309
++ ++ + +HS L Q+ + L+ I +N IR
Sbjct: 3096 LLQ-------------VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3142
Query: 8310 -------SKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 8356
S P G + +T + K ++K L +S D+ + + EE+ P
Sbjct: 3143 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3202
Query: 8357 V----NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8412
V +L + Q ++DR A ++E +++ +++ ++F S L L E
Sbjct: 3203 VGIKRDLEALSKQCNKLLDR-------AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3255
Query: 8413 EELEQLQRLELSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQ--ADSKES 8469
E E + + T+ TI Q+ K QK ++ + +N Q A S +
Sbjct: 3256 EHEESQGPVGMETE--TINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3313
Query: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
+ L+ L +N RW + + + LQ+AL+ C F + LL + + +
Sbjct: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373
Query: 8530 PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHV 8589
P + Q ++L+Q + +S + V + ++ AE D ++ +++ +
Sbjct: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE--KIATTAEPADKVKILKQLSL 3431
Query: 8590 IGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADE 8629
+ +R + LL + ++LE + V+ + + L+ W + E
Sbjct: 3432 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE 3475
Score = 159 bits (401), Expect = 2e-37
Identities = 417/2207 (18%), Positives = 833/2207 (37%), Gaps = 317/2207 (14%)
Query: 6668 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1049 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1106
Query: 6728 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6771
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1107 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1166
Query: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6831
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1167 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1211
Query: 6832 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6889
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1212 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1262
Query: 6890 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 6943
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1263 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1322
Query: 6944 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1323 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1382
Query: 7002 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7059
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1383 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1442
Query: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7108
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1443 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1502
Query: 7109 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7146
EK + S QK S KE +T L +K +
Sbjct: 1503 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1562
Query: 7147 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7190
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1563 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1622
Query: 7191 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1623 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1676
Query: 7244 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7293
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1677 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1736
Query: 7294 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7318
W+ ++ + H + T
Sbjct: 1737 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1796
Query: 7319 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7364
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1856
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7422
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1916
Query: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7470
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1917 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1976
Query: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7530
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1977 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2035
Query: 7531 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7583
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 2036 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2092
Query: 7584 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7641
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2093 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2152
Query: 7642 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7698
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2153 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2212
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2213 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2267
Query: 7759 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7817
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2268 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2326
Query: 7818 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7867
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2327 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384
Query: 7868 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7905
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2385 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2444
Query: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 7964
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2504
Query: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8022
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--VQAKIKQLKA 8080
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2624
Query: 8081 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2625 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2684
Query: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2685 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2740
Query: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSDV 8256
V E DLS ++ +A S EG + KD
Sbjct: 2741 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKD------------ 2783
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQIQQTENIIRSKTP 8313
+ + E +V+ ++A A Q +Q+ + D++ + Q + I +K
Sbjct: 2784 -VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD 2834
Query: 8314 TGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR 8372
L +K + K L S + ++ E+ L + + S + L +T
Sbjct: 2835 VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----N 2889
Query: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
W+ Q +E ++K++L+K ++ + ++W W+ + LE+ ++ D E
Sbjct: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGEN 2946
Query: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 8492
I KLK LQK +D ++ +N + + + D + + D V L
Sbjct: 2947 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 3006
Query: 8493 WRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
+ L++ + + F E+S L E +D + SN +LQ K L
Sbjct: 3007 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3066
Query: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8608
+KH++ L QD+ + +++GT + +V I L ++V L
Sbjct: 3067 ALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFL 3120
Query: 8609 E-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 8649
E KL + Q + S DELD+ V GR QK
Sbjct: 3121 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3163
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 373 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 431
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4640 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4688
Query: 432 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 485
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4689 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4732
Query: 486 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 531
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
Query: 532 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 591
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4793 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4847
Query: 592 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 645
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907
Query: 646 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 698
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967
Query: 699 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 753
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027
Query: 754 QD----LEDIEQRVPVMDAQYKIITKT 776
+ +E++ ++ P +D +TKT
Sbjct: 5028 AEHQTFMEEMTRKQPDVDK----VTKT 5050
Score = 33.5 bits (75), Expect = 9.5
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 382 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 433
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4733 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792
Query: 434 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 490
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4793 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4851
Query: 491 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 542
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4852 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4911
Query: 543 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 598
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4912 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4955
Query: 599 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 658
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4956 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4998
Query: 659 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 718
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4999 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5049
Query: 719 EY 720
Y
Sbjct: 5050 TY 5051
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 336 bits (861), Expect = 7e-91
Identities = 707/4022 (17%), Positives = 1549/4022 (38%), Gaps = 508/4022 (12%)
Query: 1235 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1292
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1463 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1519
Query: 1293 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1349
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1520 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1578
Query: 1350 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1405
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1579 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1636
Query: 1406 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1460
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1637 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1690
Query: 1461 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1513
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750
Query: 1514 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1573
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1751 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1807
Query: 1574 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1633
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1808 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1849
Query: 1634 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1680
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1850 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1905
Query: 1681 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1720
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1906 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1965
Query: 1721 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1780
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1966 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 2023
Query: 1781 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1835
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 2024 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 2083
Query: 1836 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1883
K+ + ++ A D F+ V+ L L + Q
Sbjct: 2084 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 2140
Query: 1884 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1937
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 2141 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2199
Query: 1938 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1995
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2200 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2259
Query: 1996 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2260 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2319
Query: 2056 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2320 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2379
Query: 2115 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2169
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2380 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2425
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2223
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2426 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2479
Query: 2224 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2276
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2480 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2538
Query: 2277 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2335
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2539 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2580
Query: 2336 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2395
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2581 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2639
Query: 2396 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2455
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2640 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2673
Query: 2456 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2515
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2674 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2710
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2711 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2768
Query: 2576 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2631
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2769 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2828
Query: 2632 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2689
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2829 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2888
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2889 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2947
Query: 2750 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2800
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2948 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2998
Query: 2801 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2857
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2999 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 3057
Query: 2858 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2917
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 3058 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 3099
Query: 2918 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2977
EL++ +L + + ++ V L V + + + Q +
Sbjct: 3100 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 3157
Query: 2978 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3037
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 3158 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3217
Query: 3038 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3078
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3218 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3277
Query: 3079 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3138
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3278 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3337
Query: 3139 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3198
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3338 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3391
Query: 3199 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3253
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3392 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3445
Query: 3254 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3308
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3446 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3505
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3368
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3506 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3565
Query: 3369 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3428
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3566 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3625
Query: 3429 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3482
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3626 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3685
Query: 3483 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3539
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3686 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3745
Query: 3540 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3597
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3746 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3803
Query: 3598 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYR-DEVEEVGARAQEILDESHV 3656
+ R + +++ WL E + E + +E + R +E+ E+
Sbjct: 3804 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3863
Query: 3657 NSRMGCQATQLTS-----------------------RYQALLLQVLEQIKFLEEEIQSLE 3693
N + +++S RY+ + + ++++ ++ I +
Sbjct: 3864 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3923
Query: 3694 ESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3750
+ + + + W T K + + + D+ + +K T+E+L + ++
Sbjct: 3924 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKDIID 3978
Query: 3751 SAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKC 3810
+ G + + E E + ++K++ ++ + + ++ LE+ L +F +
Sbjct: 3979 DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 4038
Query: 3811 KALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE 3870
+ L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G LLE
Sbjct: 4039 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 4098
Query: 3871 LV-------------------------------------QDVTLKDKIDQLQSDYQDLC- 3892
L Q DKIDQ+ + +
Sbjct: 4099 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4158
Query: 3893 -------------------SIGKAMMEEIAGFEDRLNNLQMKGDTLIGQC--------AD 3925
S K + ++ + L+ +G+ +I + A
Sbjct: 4159 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4218
Query: 3926 HLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA 3979
+Q KL Q N+H ++ + + A++ + H+S T++ Q
Sbjct: 4219 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIKDTQD 4271
Query: 3980 WLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLSNASV 4033
++ ++ P ++PS + AE I++ LQE+ ++L L + C + V
Sbjct: 4272 FIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPDKPIV 4329
Query: 4034 KTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH 4089
K + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4330 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4389
Query: 4090 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHLNDQ- 4146
++LE + + ++K F + +Q + + + L KK EES +H + L +
Sbjct: 4390 TDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4447
Query: 4147 --WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHL 4204
W L + N + E L + ++ + +L + A+ +
Sbjct: 4448 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4507
Query: 4205 EALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK 4262
E K L + + +E + +IE ++ ++ + L QRW + + +
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4567
Query: 4263 RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4322
++ Q L + ++L +W + + ++ + P+ A+ L H+ +C+
Sbjct: 4568 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAA 4627
Query: 4323 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4382
EAK+ KSL++ +++A + I + +++ + + + +R+ L +AL+
Sbjct: 4628 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4687
Query: 4383 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4442
+F ++ + + Q E+ + L+ D V Q+ K + +++ ++ L
Sbjct: 4688 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIEL 4747
Query: 4443 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4502
G L +Q+ + L +QS ++ V+Q+ R + L+ K F E + K
Sbjct: 4748 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4807
Query: 4503 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4562
WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4808 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4867
Query: 4563 NEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L +E
Sbjct: 4868 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4927
Query: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTGQPWQ 4677
Q V D ++ ++L D +A E+ +V L + EG R W
Sbjct: 4928 QLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WV 4984
Query: 4678 PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEET 4737
+M L T + + + + + LE +E + L L + EQ+
Sbjct: 4985 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLRFHGV 5042
Query: 4738 LPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792
LP +E + + L++ L + T + + P + +H I +
Sbjct: 5043 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 5102
Query: 4793 ELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE 4852
+ + + + S + I Q + L WL+ + L+ D + + I +E
Sbjct: 5103 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEVIPQE 5157
Query: 4853 IRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRT 4912
I +++ E Q+ + M + +K TK + +AD + + LD R
Sbjct: 5158 IEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRF 5216
Query: 4913 RQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLAGNGL 4952
++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5217 PASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDF 5276
Query: 4953 DV 4954
D+
Sbjct: 5277 DI 5278
Score = 322 bits (825), Expect = 1e-86
Identities = 858/4699 (18%), Positives = 1838/4699 (39%), Gaps = 637/4699 (13%)
Query: 3186 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3243
E++ + +QD L+ ++M + + DLP+ + ++V I +E L K
Sbjct: 780 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 839
Query: 3244 AQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWM 3303
Q+ ++ ++ +L SQY L N ++ + LD + HN S EL W+
Sbjct: 840 EIQMTA--PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELI-WL 893
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
+ +Y + ++ + E + + Q++E +K + E +L P +
Sbjct: 894 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE-NIKSVQEIAEQLLLENHPARL 952
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEA-----N 3418
TI+ +++ W+ +L C+ +E + + T+Y F + D+ EA N
Sbjct: 953 -TIEAYRAAMQTQWSWILQL---CQC-VEQHIKENTAY------FEFFNDAKEATDYLRN 1001
Query: 3419 LNESERQHAELRDKTTMLGKAKLL-------NEEVLSYSSLLET--------IEVKGAGM 3463
L ++ ++ D+++ + K + L EE+L Y S + I++K
Sbjct: 1002 LKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 1060
Query: 3464 TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQE----- 3518
T + ++ + + YR I+ + K ++ V + ++ K G E
Sbjct: 1061 DCPLKTSIPIKAICD-YRQIEI----TIYKDDECVLANNSHRAKWKVISP-TGNEAMVPS 1114
Query: 3519 ---------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPS 3569
+E +D + +E T + L+N + R + S
Sbjct: 1115 VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVAS 1174
Query: 3570 ---GIPQAEDRALESLRQDWQAYQHRLSETR-------TQFNNVVNKLRLMEQKFQQVDE 3619
+P + L +L+ ++ + E++ TQ VN + Q E
Sbjct: 1175 IKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK------QYYQE 1228
Query: 3620 WLKTAEEKKWHEEV-TAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQV 3678
LK+AE ++ E V Y EV + R + D R + L + ++
Sbjct: 1229 LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHES----VFRI 1284
Query: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGK-------- 3730
EQ K L++E++ L++ ++++ + + S +V T +++ V+
Sbjct: 1285 TEQEK-LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 1343
Query: 3731 ----KLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3786
KLKT+ ++LK+ + +L+K K L E EA K ++ L
Sbjct: 1344 TYIDKLKTVNLVLKNTQAAEALVKLYETK-------LCEEEAVIADKN------NIENLI 1390
Query: 3787 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK-YK 3845
ST++ QW +E E V + EL + KA + +K
Sbjct: 1391 STLK------------------------QWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1426
Query: 3846 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGF 3905
+ ++ L + +EK + L+E Q+V + Q+ + +DL IGK++ +
Sbjct: 1427 TYKERDLDFDWH----KEKADQLVERWQNVHV-----QIDNRLRDLEGIGKSLKY----Y 1473
Query: 3906 EDRLNNLQMKGDTLIGQCADHLQAKLKQNV--HAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
D + L D I Q + Q K+++N ++ T+ + + + M QS E
Sbjct: 1474 RDTYHPL----DDWIQQ-VETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1528
Query: 3964 LQKHVSRQD-TLQQCQAWLSAVQPDLEPSPQPPLSR----AEAIKQVKHFRALQEQARTY 4018
QK+ + T++ + + ++ + P+ R + A ++ F L+ +
Sbjct: 1529 CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL 1588
Query: 4019 LDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA 4078
+ L+ + S+K ++ + E+ ++ + +A+ L Q W S + L+DA
Sbjct: 1589 VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-QKWV------SNISKTLKDA 1641
Query: 4079 DQQLQN--MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE 4136
++ + K++ S E++ + +S+ ++ +K +K+T +E +
Sbjct: 1642 EKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG---------DKMTDEERNEL 1692
Query: 4137 HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV----EVFLEKFTTEWDNL 4192
K++ L + + L +S L++ ++ Q + D +V + + EK D L
Sbjct: 1693 EKQVKTLQESYNLLFSES----LKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1748
Query: 4193 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4252
+++ H EA ++ +KY + +++ QK ++ E+VK + L++
Sbjct: 1749 TQTENRLIG-HQEAFMIGDGTVELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKE 1805
Query: 4253 RWFQLED----LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4308
+L LI++K+ + E+LN+ + ++ E + A+K+
Sbjct: 1806 NGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK------ELDKVVTTAIKEET---- 1855
Query: 4309 AQNLLMDHLAICSELEAKQMLLKSLI---KDADRVMADLGLNERQVIQKALSDAQSHVNC 4365
+ +A +LE + +++L+ + D+ G +QVI++ + Q
Sbjct: 1856 ------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG- 1908
Query: 4366 LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4425
+G+ + L + Q + Q +K+ ++ K
Sbjct: 1909 -KSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKVK------------AQHEKII 1953
Query: 4426 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL------QKC 4479
QA + Q+ L QG+ L E EK ++ ++EL+ Y++ L K
Sbjct: 1954 SQHQAVIIATQSAQVLLEKQGQYLSPE----EKEKLQKNMKELKVHYETALAESEKKMKL 2009
Query: 4480 SHRLQE-LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE----LHTQLAKY 4534
+H LQE LEK F D+ + HWL+Q++ E+ + ++ L T+L +
Sbjct: 2010 THSLQEELEK-------FDADYTEFEHWLQQSE----QELENLEAGADDINGLMTKLKRQ 2058
Query: 4535 QNILEQSPEYENLLLTLQRTGQTILPSLN--------EVD----HSYLSEKLNALPRQFN 4582
++ E ++ L + +G +L + +VD H + KL+ +F
Sbjct: 2059 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR 2118
Query: 4583 VIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ 4642
+ + +++ + +Y + + L+ L+A SK ++ + +LQ
Sbjct: 2119 SLYSKCNVLGNNLKDLV---DKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2175
Query: 4643 ---DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK------MLHLVTLYHRLKR 4693
+ +A+ +++ AV++L + E P K + +V Y L +
Sbjct: 2176 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2235
Query: 4694 QTEQRVSLLEDTT----SAYQEHEKMCQQLERQLKSVKEE-QSKVNEETLP--AEEKLKM 4746
+R L+ T S ++M + S+KE+ Q +N L + + +
Sbjct: 2236 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2295
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+AG + ++V +E DP + +++ + ET+
Sbjct: 2296 EQDIAGRQSSINAMNEKVKKFMETT----DPSTASSLQAKMKDLSARFSEASHKHKETLA 2351
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
+ E + ++ +S L K + V D+ +D+ E + +Q E
Sbjct: 2352 KMEE-LKTKVELFENLSEKLQTFLETKTQALTEV--DVPGKDVTELSQYMQESTSEFLEH 2408
Query: 4867 LRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQR 4926
+ + L KE + A + LS+ ++++ ++ ++ +T Q
Sbjct: 2409 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2468
Query: 4927 YYQVFQAANDWLEDAQE---LLQLAGNGLDVESAEENLKSHMEFFSTE----DQFHSNLE 4979
+ + ++ W+++ + ++Q + D+ + E+ K E +S + + +++
Sbjct: 2469 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2528
Query: 4980 ELHSLVATLDPLIKP-----------------TGKEDLEQKVASLELRSQRMSRDSGAQ- 5021
L +L++ + K T E+ ++ G +
Sbjct: 2529 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYED 2588
Query: 5022 -----VDLLQRCTAQWHDYQKAREE---VIELMNDTEKKLSEFSLLKTSSSHEA-EEKLS 5072
D + + QKA+EE +++ + K +++ + EA + ++
Sbjct: 2589 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2648
Query: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTT-VWQRWTRLRAVAQDQ 5131
++K+ + + K+ L++K ++L + D +A + M T + +W L + D+
Sbjct: 2649 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2708
Query: 5132 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV---- 5187
++ LE++ + T F ++ +L EK +L L +
Sbjct: 2709 QQKLEESSNNLTQFQT-----------VEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2757
Query: 5188 --LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLM----QEITAMQDRCLNMQEKVK 5241
+++ Q+ A + + L+ G PGE+P L +++ A+ + ++ ++
Sbjct: 2758 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2817
Query: 5242 TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI------EIDAQLEELQILLTE 5295
+ Q + ++ + S+ + + L + ++ QLE Q + E
Sbjct: 2818 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2877
Query: 5296 ATNHRQNI-------EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIK 5347
++ I E ++ KE+YL +ELS QL + K + + ++ ++
Sbjct: 2878 IQQEKKQIKVAQALCEDLSALVKEEYL------KAELSRQLEGILKSFKDVEQKAENHVQ 2931
Query: 5348 EVEQSKATS---QELSRQIQK---LAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5401
++ + A+S Q++SR Q K+ + AK D + D K + L
Sbjct: 2932 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA- 2990
Query: 5402 NSKLMELDAAVQK--FLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5459
S + E A + L+ G L ++ + +Q + R +KL ++
Sbjct: 2991 QSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 3050
Query: 5460 EYNEMLELILKWIEKAK----------VLAHGTIAWNSASQLREQYILHQTLLEESKEID 5509
+Y E +E + WI+K + A G + L+++ H ++E
Sbjct: 3051 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA 3110
Query: 5510 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5569
+ L ++ E + T++ + ++ TE+L K L+N+ K+ ++ E
Sbjct: 3111 NSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KFCLENMTQKFKEFQEVSKE 3165
Query: 5570 LKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ-AVQLCQSALRI 5627
K+ LQ A EQ + + + L+ Q +++LK +V A +L Q +
Sbjct: 3166 SKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVE 3223
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
D + + + +E S L ++C+ ++ + ++ ++ +
Sbjct: 3224 ASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD 3283
Query: 5688 REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5747
E++ + + LQ Q + +K++ + N CKM+ + + L+ +
Sbjct: 3284 DELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGI 3343
Query: 5748 -TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE-----ESGEEGTNSE 5801
++E L++ +LL A V T R S + E + EE S+
Sbjct: 3344 KRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3399
Query: 5802 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5861
PV ++NQ + ++ E ++ K Q + + +
Sbjct: 3400 ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3449
Query: 5862 ATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS-ISTKMEAIELKLS 5916
+T L D+ W+TL ++++ L EAL ++QD+L+S +S ++ EL +
Sbjct: 3450 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3509
Query: 5917 ESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE-----ADPAEQLA 5971
+ P P ++ +A + E +LQ +++ +S++ E++ E A+PA+++
Sbjct: 3510 QKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVIKREGEKIATTAEPADKVK 3562
Query: 5972 LQSTLTVLAERMSTIRMKASGKRQLLE-------------EKLNDQLE--EQR------- 6009
+ L++L R + KA + + LE E LN+ L E+R
Sbjct: 3563 ILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPI 3622
Query: 6010 --QEQALQRYRCEADELDSWLLSTKATLDTALS--------PPKEPMDMEAQLMD-CQNM 6058
Q L+ + L+ +++ L A+S +E DM +D Q
Sbjct: 3623 GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW 3682
Query: 6059 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QLAGKLRRL----------- 6101
+EI++K + SEL + L K +DE E ++ KL +L
Sbjct: 3683 YIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3739
Query: 6102 --KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6159
+ L LQ + ++ N+ E T + +Q+ L + + + S
Sbjct: 3740 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3799
Query: 6160 LQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG-MEGEKS 6218
K LEQ L L R + S EE+ E ++LS E ++GE++
Sbjct: 3800 TDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV--------ELLSYETQVLKGEEA 3847
Query: 6219 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S Q +M+ + L +E + LL + L + +L P R G+ + +D
Sbjct: 3848 S---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWRAREGLE----KMVAEDNE 3899
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 6338
+ D + Q EE+ + +I Q+ A +W+ + E++L +
Sbjct: 3900 RYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3951
Query: 6339 EETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
E+ +T F EIL K++ +++ K+ + A E + + ++ L +L
Sbjct: 3952 EQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTACSE--EEKQSMKKKLDKVL 4007
Query: 6392 GRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADNKYIILQKLANVFE-QPVA 6449
+ + ++R Q+ ER Q ++N F + L+ L + + II Q A E + +
Sbjct: 4008 KNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 4066
Query: 6450 EQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQELSKLQD-MYDELMMIIG 6504
+Q E +Q + + E I ++ + G +L P S+QE D +Y ++ +
Sbjct: 4067 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 4126
Query: 6505 SRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQ 6564
R L++ ++ +Q+ + + + LE E++ I + E+I++ + ++K
Sbjct: 4127 KRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSV 4185
Query: 6565 GLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVE--LEYILETWSH 6622
+E L ETL Q E++A++ K + V+ L+ ++ W +
Sbjct: 4186 DMEKLQPLYETL------------KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4233
Query: 6623 L----DEDQQELSRQLEVVE-------SSIPSV----GLVEENEDRLIDRITLYQH---- 6663
+ +E + +L +E+ E S I ++ + + ED ID + Q
Sbjct: 4234 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4293
Query: 6664 --LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHR 6718
++ ++ Q +L V++ G L+ + D ++ +++L W S + +
Sbjct: 4294 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4353
Query: 6719 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV 6778
LE ++ +YQ + W+ A +L + + +LE V+ + +F E
Sbjct: 4354 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTDLETVKQQIEELKQFKSEA 4409
Query: 6779 DAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 6834
Q ++ L+ +LL LKKV D T++ L + W L I Q KL
Sbjct: 4410 -YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4467
Query: 6835 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCK 6892
+ +HA+ E+++W++ E ++ + + +G KAI L K+ + D+
Sbjct: 4468 LLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKAIEIELAKHHVLQNDVLAH 4522
Query: 6893 QLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q TV+ VN++ + +ES ++ ++ +L +N+ WQ + ++ Q L+G L
Sbjct: 4523 QSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4578
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ ++ L+ W E+ L +G + + L ++ +AKE+ + +
Sbjct: 4579 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4638
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
Q G ++ + + + + L + W +++ + + K L+ L+ +
Sbjct: 4639 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4698
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++L +A +L+ + L+ V Q+D + +++ + + L
Sbjct: 4699 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4758
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKALLQLWQRYKDYSKQCAST 7183
+ N L V RW +++ + E+ +S +K + W + ++ ++ +
Sbjct: 4759 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4818
Query: 7184 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
+ + + N+ D++ T + + K LG + G LK++
Sbjct: 4819 LDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK- 4866
Query: 7244 DASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQAGVLDYETFAKSLEALEAW 7296
+++ D L L L L +C ++Q L+ +L F +L+AL W
Sbjct: 4867 -----TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDW 4921
Query: 7297 IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7356
+ E L P H D+ + ++ K + + L L ++
Sbjct: 4922 LYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4980
Query: 7357 K-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7411
+MQ L+ W + + + + ++L++ L Q + F +E+L + EQ L
Sbjct: 4981 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 5040
Query: 7412 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLL 7469
+ + L H+ F ++ ++ L+ G +L D +T++
Sbjct: 5041 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 5100
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-EVSYLPMSGLGSVPIPLQQ 7528
+++ V+ A+Q + + S + +E+ E L WL + L +P +++
Sbjct: 5101 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 5160
Query: 7529 ARTLFDEVQ-FKEKVFLRQ 7546
+ L E Q F E++ +Q
Sbjct: 5161 VKALIAEHQTFMEEMTRKQ 5179
Score = 312 bits (799), Expect = 1e-83
Identities = 770/4311 (17%), Positives = 1668/4311 (38%), Gaps = 501/4311 (11%)
Query: 1482 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1535
S S + ++ V Q + L S E+E + +++ + R++ + + Q
Sbjct: 1208 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1267
Query: 1536 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1594
IR E H T L ++ ++ +++L I EF + A + + +E
Sbjct: 1268 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1327
Query: 1595 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1654
VLQ + S+SS + V+ Q A AL + YE L
Sbjct: 1328 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1376
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
E ++A +E +S+ W R +V+ + Q+ AL++E+
Sbjct: 1377 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1414
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
K + + +F + D+ K +QL ERW+++ I+ R+ L+ +
Sbjct: 1415 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1468
Query: 1773 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1824
+ + + WI+ +++TT I ++Q L + K +E+E K+
Sbjct: 1469 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1523
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1881
++ Q + + + + +L + +A + + V+RR++ S + EF+
Sbjct: 1524 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1579
Query: 1882 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1938
+ ++ + Q ++ A +S+ + E + +E++ + ++ AK L+ ++ L
Sbjct: 1580 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1639
Query: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1998
A+ K S+Q+ S ++++ + E++ L T Q L + K
Sbjct: 1640 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1681
Query: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2057
++ TD+ER N+LE ++ + + L + KQ+ +
Sbjct: 1682 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1719
Query: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
+ +V+ +I E + + G+ DL+ + +N +++ + + ++
Sbjct: 1720 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1764
Query: 2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2176
T+ +LK SK E + M + L ++ L E +K+ D +L++
Sbjct: 1765 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1820
Query: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2236
+ K ++ K E++ L D V++T + E V Q+ E+ + ++N
Sbjct: 1821 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1873
Query: 2237 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2296
L ++ S V + R H +V + F E D +
Sbjct: 1874 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1916
Query: 2297 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2356
E+ T D +TQ ++ + KV+ AQ+E K +
Sbjct: 1917 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1953
Query: 2357 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2410
Q+ I +TQ L + E E L + M L +E A S+ K SL
Sbjct: 1954 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 2013
Query: 2411 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470
QE LEK F EF+ W ++ + D L KL ++ + V + L
Sbjct: 2014 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 2072
Query: 2471 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2518
+T G + ++ +S +Q ++ A + F++ +C L+
Sbjct: 2073 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 2132
Query: 2519 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2577
D + +ED L + E + ++L E P+ + ++ + + G++ +
Sbjct: 2133 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2191
Query: 2578 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
+ +++KL + + LL G + ++ +++L + E+ Q+ L
Sbjct: 2192 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2251
Query: 2634 EALEEALQSMWFWVKAIQDRLA----CAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN 2689
++++ L M W+ ++ L ++ +D + K + QDI + +N
Sbjct: 2252 LSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI----AGRQSSIN 2307
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
K ++ + +++ +Q +++ L +++ + +E + ++ +
Sbjct: 2308 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2367
Query: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--- 2806
+L+ ++E+ Q + P + E + S E + H LH L+ +
Sbjct: 2368 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL 2427
Query: 2807 ------LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD------ 2854
+ EKT + S K E+ + + +T +E++ + +VK ++
Sbjct: 2428 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2487
Query: 2855 -------AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRV 2907
+ L K+ +WS + + + LI + A ++ V
Sbjct: 2488 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2547
Query: 2908 ESLAPEVKQNTTASGCELMHTE--MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965
+S + TA+ E + +++ D L++ ++ E
Sbjct: 2548 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA-------EL 2600
Query: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGK------NTDEEIVECWHKGQEILDA-LQK 3018
+ ++++L++A E+ SA+++ W Q++ K TD E V+ + + +A L++
Sbjct: 2601 NTKLSKLQKAQEESSAMMQ-WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2659
Query: 3019 AEPRTEDLKSQLNELCRFSRDL------STYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
+ ++LK +L EL + D ++ +E N L + + + L
Sbjct: 2660 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2719
Query: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132
Q F+ +QWLV ++ + + + + ++T Q++Q L E + + +
Sbjct: 2720 TQ-FQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2778
Query: 3133 SKGE-LLSTLLTKEKAKGI-QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAE 3190
+ G+ +LS +GI + ++ A + W + L + ++ ++ ++
Sbjct: 2779 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2838
Query: 3191 PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEG 3250
+ D LS + + S A ++ + Q + +EI + Q+ + AQ L E
Sbjct: 2839 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI----KVAQALCED 2894
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKE-------KVSRLDRIVAEHNQFSLGIKELQDWM 3303
+A + ++LS Q + K+ V L A +QF ++ Q W+
Sbjct: 2895 LSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL 2954
Query: 3304 TDAIHMLDSYCHPTSDK-SVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362
D + HP S K VL+S + + + + GE++L T
Sbjct: 2955 -DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE 3013
Query: 3363 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE- 3421
+Q QL ++K W + +++L+ +L K Y++ V W+D + NL E
Sbjct: 3014 KAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI 3073
Query: 3422 --------SERQHAELR----DKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
E A+L+ + G +LLN +SLL E+ +T+
Sbjct: 3074 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA---NSLLSVCEIDKEVVTD---- 3126
Query: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529
E + L ++ + E+ E + + +E+Q K + L +E+LD + L
Sbjct: 3127 --ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3184
Query: 3530 GDAHTHE-TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRAL--ESLRQDW 3586
A++++ T+ Q+ + + Q L L V S D L E++ Q+
Sbjct: 3185 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3244
Query: 3587 QAYQHRLSE------TRTQ-FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDE 3639
++ E T+ Q + N +R M +F + D+ L + E + E
Sbjct: 3245 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3304
Query: 3640 VEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL------- 3692
+ + E L S+ N+ C+ T L+ + ++ L ++ L
Sbjct: 3305 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3364
Query: 3693 -EESESSLSSYSDWYGSTHKNFKNVATKIDK---------VDTVMMGKKLKTLEVLLKD- 3741
E+ E ++ ++Y S K F + K ++ ++T + ++L +V K+
Sbjct: 3365 EEQVEGTIKRLEEFY-SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3423
Query: 3742 MEKGHSLLKSAREKGERAVKYLEEGEAER-LRKEIHDHMEQLKELTSTVRKEHMTLEKGL 3800
+E + G+ ++ + + + L ++ D + K L V + L++ L
Sbjct: 3424 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3483
Query: 3801 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3860
F D ++L W+ + +E++ + P E KAQ+ + K LQ+ + + +V+
Sbjct: 3484 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3543
Query: 3861 VREKGEALL---ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
++ +GE + E V + ++ L S ++ L + KA N Q++G
Sbjct: 3544 IKREGEKIATTAEPADKVKILKQLSLLDSRWEAL--LNKA----------ETRNRQLEGI 3591
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977
+++ Q L + + T + C LE ++ +H + +D +
Sbjct: 3592 SVVAQQFHETLEPLNEWLT-----TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3646
Query: 3978 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037
L +S +++K + +R D++ S D S
Sbjct: 3647 NKHLHQA-----------VSIGQSLKVLS--------SREDKDMVQSKLDFSQVWYIEIQ 3687
Query: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELEL 4094
+ + ++Q L A+ + E+ + +E+ L D + + ++ SEL
Sbjct: 3688 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR- 3746
Query: 4095 NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS 4154
V Q ++K QA +N + E + + T E ++ + ++ D+ + S
Sbjct: 3747 ------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3799
Query: 4155 NNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4209
++ E+ LQ R H C + +V +E + E L +A + + LKK
Sbjct: 3800 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3859
Query: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VS 4268
A + K ++ L + ++E + +E +++ + +R+ + D I +K++ +
Sbjct: 3860 EA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3916
Query: 4269 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328
L Q+ EL W E + + D L E+ +
Sbjct: 3917 AAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKD 3975
Query: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388
++ L+K ++M E+Q ++K L + + + + +R L +A S QF
Sbjct: 3976 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 4035
Query: 4389 MAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4448
+ + + + I L + + +Q + + + + ++ + + G +
Sbjct: 4036 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 4095
Query: 4449 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4508
L+ E++ E + K ++Y + + R L++ + F + D+ L+
Sbjct: 4096 LL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 4154
Query: 4509 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHS 4568
+ ++ E ++ Q+++ +N+ + + L TL++ G+ ++ D
Sbjct: 4155 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4214
Query: 4569 Y----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQF 4623
+ +KL+ + + I L +++ K+ + + LA K + + L ++ + + F
Sbjct: 4215 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DF 4272
Query: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP---D 4679
+R + P + Q+ I +E+ GL E +D +N E + G+P +P
Sbjct: 4273 IRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4331
Query: 4680 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE---- 4735
+ L + + L + + R+ LE+ A +++ Q + + + + ++
Sbjct: 4332 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD 4391
Query: 4736 -ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGE 4793
ET+ + E+LK + S A Q I ++R+ E L L + E +H +Q E
Sbjct: 4392 LETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLME 4445
Query: 4794 LKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4849
LKL+ ++ E + + ++ ++ FQ + L WL + LS + + + I
Sbjct: 4446 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505
Query: 4850 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4909
+ E+ K + Q +V + + A++ + + +++L++ L L++ ++ E
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME- 4966
R+ L Q + ++ + WL D + L LA L E+A+E L HME
Sbjct: 4566 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHMEV 4624
Query: 4967 ---FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5023
F + E+ + S +++ ++A + + +++Q + +L+ + + + +
Sbjct: 4625 CAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERKT 4680
Query: 5024 LLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVSV 5080
L+ ++ + ++ I + E+ L S SL+ + + + EHK +
Sbjct: 4681 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFANE 4736
Query: 5081 VNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140
VNS E+I+ L++ + L+ + + +V RW ++ ++ + L+DA
Sbjct: 4737 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4796
Query: 5141 EWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGML 5200
F+ K E +++ + L ++ T L H F L + S
Sbjct: 4797 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4856
Query: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV-- 5257
+ S+ E+ L + + D +++K T GK V+++ K E +
Sbjct: 4857 NRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLF 4907
Query: 5258 ----ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQKE 5312
+ ++ W+ Y P + D + ++ +++ NH+ +
Sbjct: 4908 SGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AFQ 4953
Query: 5313 KYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTT 5372
K LG T S+Q AL R+ I+ + K QELS + + + +
Sbjct: 4954 KELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSIS 5004
Query: 5373 ILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGK 5432
T+L+A EE L+E A ++ L +G L +
Sbjct: 5005 KQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRT 5052
Query: 5433 LTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWNS 5487
L + H++ +++ E + ++LN+A + + + + + I WI + +AW
Sbjct: 5053 LIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAK 5112
Query: 5488 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQ 5547
Q R L + ++ LEA+ LQ+ + T+K + + + E EE++
Sbjct: 5113 QHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVKA 5163
Query: 5548 MI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
+I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 5164 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5214
Score = 298 bits (764), Expect = 1e-79
Identities = 722/4020 (17%), Positives = 1553/4020 (38%), Gaps = 449/4020 (11%)
Query: 4877 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1286 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1345
Query: 4928 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 4972
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1346 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1405
Query: 4973 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5026
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1406 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1465
Query: 5027 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1466 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1522
Query: 5085 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5142
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1523 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1582
Query: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5202
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1583 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1635
Query: 5203 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5256
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1695
Query: 5257 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5316
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1743
Query: 5317 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5359
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1744 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1803
Query: 5360 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5414
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1804 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1863
Query: 5415 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5468
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1864 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1922
Query: 5469 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5525
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1923 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1979
Query: 5526 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1980 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 2039
Query: 5586 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5634
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 2040 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 2099
Query: 5635 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5690
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 2100 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 2148
Query: 5691 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5748
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 2149 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2196
Query: 5749 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5796
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2197 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2256
Query: 5797 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5848
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2257 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2314
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2315 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2374
Query: 5909 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 5968
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2375 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2433
Query: 5969 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6018
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2434 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2493
Query: 6019 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2494 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2551
Query: 6079 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6135
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2552 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2611
Query: 6136 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6184
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2671
Query: 6185 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6228
E+L E + D E P D QEL + E+SS
Sbjct: 2672 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2725
Query: 6229 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6266
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2726 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2785
Query: 6267 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6323
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2786 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2844
Query: 6324 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6383
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2845 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2900
Query: 6384 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2901 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2958
Query: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6487
P++ +++ ++ K+F + +K E ++
Sbjct: 2959 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 3018
Query: 6488 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6546
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 3019 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 3078
Query: 6547 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6602
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 3079 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3138
Query: 6603 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6659
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 3139 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3194
Query: 6660 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6715
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3195 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3254
Query: 6716 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6775
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3310
Query: 6776 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6833
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3311 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3370
Query: 6834 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6889
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3371 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3427
Query: 6890 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 6949
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3428 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3482
Query: 6950 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7008
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3483 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3542
Query: 7009 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7068
I++ G + + ++ L L W L + L+ +
Sbjct: 3543 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3602
Query: 7069 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7128
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3603 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3661
Query: 7129 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7174
+ + + + + W EI E+ S LLQ +
Sbjct: 3662 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3718
Query: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7229
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3719 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3778
Query: 7230 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7283
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3779 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3837
Query: 7284 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7343
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3838 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3872
Query: 7344 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7397
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3873 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3932
Query: 7398 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7455
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3933 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3992
Query: 7456 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3993 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 4051
Query: 7516 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7573
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 4052 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 4102
Query: 7574 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7630
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 4103 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4161
Query: 7631 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7679
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 4162 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4220
Query: 7680 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7739
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4221 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4280
Query: 7740 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4281 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4340
Query: 7796 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7853
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4341 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4397
Query: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4398 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4454
Query: 7914 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4455 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4514
Query: 7974 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8033
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4515 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4574
Query: 8034 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8093
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4575 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4633
Query: 8094 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8150
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4634 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4674
Query: 8151 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8209
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4675 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4722
Query: 8210 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 8269
+ + D + ++ S + + D+ G K F + V L ++ + K+
Sbjct: 4723 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4781
Query: 8270 ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELD------TSYK 8323
+ ++ A + +Q +A ++++E + S+ + D +K
Sbjct: 4782 QRLVERGRSLDDA-RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4840
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ +
Sbjct: 4841 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVER 4897
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8443
+ ++++ L QF L ++ WL E +L + Q + DI + I K QK
Sbjct: 4898 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKE 4955
Query: 8444 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8503
+ R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4956 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 5015
Query: 8504 CQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 5016 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAEL 5071
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 5072 NKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 5131
Score = 295 bits (754), Expect = 2e-78
Identities = 767/4203 (18%), Positives = 1632/4203 (38%), Gaps = 605/4203 (14%)
Query: 4269 VTNLE-ELNVVQSRFQELMEWAEEQQPN-------IAEALKQSPPPDMAQNLLMDHLAIC 4320
+T LE E+NV + +QEL++ AE ++ I+E + ++ L+ +
Sbjct: 1212 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1271
Query: 4321 SELEAKQMLL------KSLIKDADRVMADLGLN----ERQVIQKALSDA----QSHVNC- 4365
E + + + L K+ +R+ DLG E Q A S + +S +N
Sbjct: 1272 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1331
Query: 4366 ---LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422
++ + Y++K L L A + ++ +E K+ E + +++ +
Sbjct: 1332 LQNMNQVYSMSSTYIDK-LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1390
Query: 4423 KTCKSAQASLK-------TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV--YD 4473
T K ++ + ++E+ A E+ K E++ K + Q V +
Sbjct: 1391 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1450
Query: 4474 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFP-EINLMNESSELHTQLA 4532
+V + +RL++LE S K++++ + W++Q + + N S L TQL
Sbjct: 1451 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1510
Query: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVA--LAKD 4590
+ + ++ + ++ + Q+ + ++ + + ++ + +Q + + +
Sbjct: 1511 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1570
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILD 4650
+QE + R Y +L+ L TQ + R+ EE SL++ + ++
Sbjct: 1571 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE--------EEEKSLEEEKKEHVE 1622
Query: 4651 EVAGLGEAVDELNQKKEGFRSTGQP----------------WQPDKMLHLVTLY---HRL 4691
+ L + V +++ + G+P Q + L + L+ H
Sbjct: 1623 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1682
Query: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
K E+R L + + + + + + +QL+ + EE + AE + + L
Sbjct: 1683 KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQ 1742
Query: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
G R+ H E + +K + + + Q +++ A+ E V E+
Sbjct: 1743 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF 1802
Query: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL-RIM 4870
+ ++ + ++ ++L ++ L + + + ++ + E+ + L +++
Sbjct: 1803 LKENGEKLSQEDKAL---------------IEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1847
Query: 4871 NALSHKEKEKFTKAKELISAD--LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYY 4928
+E EK K+L + +E+ L LS +D D + A + ++ Q ++
Sbjct: 1848 TTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHK----QVIEQNGTHF 1903
Query: 4929 QVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKS--------HMEFFSTEDQFHSNL 4978
Q + E+ + L +D V + +ENL H + S
Sbjct: 1904 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1963
Query: 4979 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5038
+ L+ + P KE L++ + L++ + +S ++ L + +
Sbjct: 1964 QSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 2023
Query: 5039 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5098
E + +E++L + KL K SF E +++ + +
Sbjct: 2024 YTEFEHWLQQSEQELENLEA-GADDINGLMTKLKRQK-------SFSEDVISHKGDLRYI 2075
Query: 5099 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5158
+GN +A S S + T A ++ ++ L+ A D + +K +
Sbjct: 2076 TISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 2133
Query: 5159 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5218
L DK Y D L Q+
Sbjct: 2134 LVDKYQ----------------HYEDASCGLLAGLQAC---------------------- 2155
Query: 5219 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5278
E TA + ++ E + + K ++++L++ + ++ QI+S + V++ K+
Sbjct: 2156 ------EATASK----HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK---TA 2202
Query: 5279 TIEIDAQ------LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LA 5330
+ +DA+ ++Q L + +++ K E+ EK L L LS+Q L
Sbjct: 2203 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK---LQITLTRSLSVQDGLD 2259
Query: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
E+ L ++ +KE Q S L I K N++
Sbjct: 2260 EM---LDWMGNVESSLKEQGQVPLNSTALQDIISK-----------------NIM----- 2294
Query: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNG-QLGKPLAKKIGKLTELHQQTIRQAENRLS 5449
L +++ G S + ++ V+KF+E L K+ L+ + + + L+
Sbjct: 2295 ---LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2351
Query: 5450 KLNQAASHLEEYNEMLELILKWIE-KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI 5508
K+ + + +E + + E + ++E K + L + ++L QY+ T E E
Sbjct: 2352 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL-SQYMQEST--SEFLEH 2408
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565
LE + L+ ++S + ++ L ++ +E+ IK + + + + +
Sbjct: 2409 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2468
Query: 5566 FEAELKKLQAALEQA--QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ---- 5619
F+ +K L++ +++ + + P G L + L + L + P++Q V
Sbjct: 2469 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2528
Query: 5620 -LCQ--SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676
LC SA+ P +A++ A L + A+ + + + +
Sbjct: 2529 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG--LTSIKKDMTDISHGY 2586
Query: 5677 KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG----YQEQIASLNS--- 5729
+ L L++ E+ K S +Q+ Q + S + QK+ +Q+ A ++
Sbjct: 2587 EDLGLLLKDKIAELNTK---LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2643
Query: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA--GRCHTL-- 5785
K ++ K+ A + V +V+ L + +L E TP A M+T + L
Sbjct: 2644 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2703
Query: 5786 LSPVTEESGEEGTNSE--------------ISSPPACRSPSPVANTDASVNQDIAYYQAL 5831
L+ ++ EE +N+ + P++ +N Q L
Sbjct: 2704 LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2763
Query: 5832 SAERLQTDAAKIHPSTSASQEFYE-PGLEPSATA----KLGDLQRSWETLKNVISEKQRT 5886
E T + T+A Q PG +PS +L + + W++L +S++
Sbjct: 2764 LQE-FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2822
Query: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQ 5943
+ +A+ + +YQ L+S+S K+ ++ KLS S P++ Q+ Q + EI +
Sbjct: 2823 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2882
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
+I Q +L E+L + E +L+ Q L + + + KA Q L+
Sbjct: 2883 KQIKVAQ-ALCEDLSALVKEEYLKAELSRQ--LEGILKSFKDVEQKAENHVQHLQSACAS 2939
Query: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDM-----------EAQL 6052
+ Q+ + Q + E + A LD S K+ D E +
Sbjct: 2940 SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2999
Query: 6053 MDCQNMLVEIEQKVVALSELSVH---------------NENLL---LEGKAHTKDEAEQL 6094
+ +N+L++ + A +L ++ EN L LE K++ E L
Sbjct: 3000 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 3059
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + + +L E++ L E E S L + Q Q +
Sbjct: 3060 WPWIDKCQNNLEEIKFCL---------DPAEGENSIAKLKSLQKEMDQHF---GMVELLN 3107
Query: 6155 QRQSSLQQQKELEQELA--EQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG 6212
+SL E+++E+ E KSL++ V E++ + E ++ +S+E
Sbjct: 3108 NTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-- 3165
Query: 6213 MEGEKSSAEDQMRMKWESLHQEFS--------TKQKLLQNVLEQ-------EQEQVLYSR 6257
+ + A++Q+ + Q +S T+QK LQ + Q Q+ V+ +
Sbjct: 3166 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEAS 3225
Query: 6258 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVS 6317
++ S V L + + Q+ S ++ +D +F E Q G H + + + S
Sbjct: 3226 DSKGTSDV-LLQVETIAQEHSTLSQQVDE-KCSFLETKLQGIG------HFQNTIREMFS 3277
Query: 6318 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL-----FSQA 6372
+ + D+++ + A + + ET +E + +K++ M N N A
Sbjct: 3278 QFAEFDDELD-----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3332
Query: 6373 FPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK---VLFTSL 6429
E + I+ L L + + L R Q++ ++++ F + LK +L
Sbjct: 3333 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3392
Query: 6430 ADNKYI---------ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
+++ + + N+F+ E+IE +Q + + G+I+ + Q
Sbjct: 3393 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3452
Query: 6481 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 6540
+ +L + + L + R + L + L +++ AL+ L + E++
Sbjct: 3453 GLE---HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM-VDTEELVA 3508
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 6600
+QK + + ++ + + K + L+ E + R+ A E +++ Q S
Sbjct: 3509 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3568
Query: 6601 -------AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR 6653
A+L +A R +LE I E + L+ L +E + + + +
Sbjct: 3569 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3628
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTN 6710
L ++I ++ L+ + + L+Q + G+ L + S D ++S+L+ ++
Sbjct: 3629 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688
Query: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE-----------FWTQQSVTVPQ 6759
K L+ L + + + +L++WL D+L W QQS
Sbjct: 3689 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS----- 3743
Query: 6760 ELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWT 6818
EL ++++ + L + VD L G +LL+ D ++ +L I +++
Sbjct: 3744 ELRVLQEDI---LLRKQNVD-------QALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3793
Query: 6819 D---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 6875
D L T++ E+ QL +L S H E+ +W+ +E + E +
Sbjct: 3794 DITKLSTDVAKTLEQALQLAR-RLHSTH--EELCTWLDKVEVELLSYETQV--------- 3841
Query: 6876 HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD------KTDFAEQLGAMN 6929
L+ + + + K+L + N L S +V S + + + + N
Sbjct: 3842 ---LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3898
Query: 6930 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK-------QQHRIGD 6982
+ ++++ +T+K++ ++ + +++ +W EK+L +Q +
Sbjct: 3899 ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3958
Query: 6983 QASVQNA-----LKDCQDLEDLIK---------------AKEKEVEKIEQNGLALIQNKK 7022
Q VQ L+ ++DL+K + +K+++K+ +N + Q
Sbjct: 3959 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 4018
Query: 7023 EDVSSI--VMSTLRELGQTWANLDHMVGQLKILL--------------------KSVLDQ 7060
E + S + + +T+ L + + + ++ + + +
Sbjct: 4019 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 4078
Query: 7061 WSSHKVAFDKINSYLMEARYSLSRFRLLTG---SLEAVQVQVDNL-QNLQDDLEKQERSL 7116
+ HK DK+N + L G S++ V D L +++D++K+ +L
Sbjct: 4079 IAEHKPHIDKMN------KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVAL 4132
Query: 7117 QKFGSITNQLLKECHPPVTETLTNTLKEVNM--RWNNLLEEIAEQLQSSKAL---LQLWQ 7171
+ S + Q + + E+L ++ + + +E+I EQ+ +K + ++ Q
Sbjct: 4133 DEAISQSTQFHDKI-DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQ 4191
Query: 7172 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATW-------------IQDCNDL 7218
+ KQ + + T++ + A +D D V W + D +L
Sbjct: 4192 PLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4251
Query: 7219 --------LKGLGTVKDSLFFLHELGEQ------LKQQVDASAASAIQSDQL-------- 7256
+ + T+KD+ F+ +L + +KQQ +A+ + D L
Sbjct: 4252 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4311
Query: 7257 SLSQHLCA-----------------------LEQALCKQQTSLQAGVLDYETFAKSLEAL 7293
+L L A L +A + L+ + + L+A+
Sbjct: 4312 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4371
Query: 7294 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYRLP 7350
W+ A L P +DL T+++++EELK + +++RLN EL +
Sbjct: 4372 FDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4430
Query: 7351 LNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7406
+ + +Q+ L W + + R KL+ LL F + + +L TE
Sbjct: 4431 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4490
Query: 7407 KLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 7464
L+ + + G+ + + + H + Q ++ + Q + ++ G L+E ++
Sbjct: 4491 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4550
Query: 7465 KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS--YLPMSGLGSV 7522
KL +L+ +WQ V+ + +QR+ +D +RQ + + E L++WL + L LG +
Sbjct: 4551 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4610
Query: 7523 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7582
P ++ + EV F ++ +Y ++ G+Q+L AE + ++ ++EK
Sbjct: 4611 PETAKEQLNVHMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEK 4667
Query: 7583 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS-QSLPDHHEELHAEQM 7641
W+S +L E+K KL L + + D + L ++ L+ S P + Q+
Sbjct: 4668 WESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQI 4727
Query: 7642 -RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7700
K N V S + + +L L + D+ ++ + +Q +WE++ +L R
Sbjct: 4728 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4787
Query: 7701 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEE 7754
+ + + F E +L EWL ES+ S + ++ I +K+K K++Q+
Sbjct: 4788 GRSLDDARKRAKQFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4845
Query: 7755 IAIAQENKIQLQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+ + G L K S +++ L ++ D+W + R KL+E L
Sbjct: 4846 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4905
Query: 7814 VAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ Q + +L WL +E +LA +P+ D + + ++ + Q+++ K ++
Sbjct: 4906 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD---IDLVMNLIDNHKAFQKELGKRTSS 4962
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
V ++ L+ + D+ +Q + L RW +CA+S+ ++ ++E R +
Sbjct: 4963 VQALKRSARELI---EGSRDDSSWVKVQM--QELSTRWETVCALSISKQTRLEAALRQAE 5017
Query: 7932 KFLDDYSRFEDWLKSSERTAAF----PSSSGVIYTVA---KEELKKFEAFQRQVHECLTQ 7984
+F +WL +E+T F P + T+ KE +KK E + ++++ T
Sbjct: 5018 EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTM 5077
Query: 7985 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL-------QKRVTSILRRLKHFIG 8037
+ + DS ++K + R++ + Q+R+ S L L I
Sbjct: 5078 GDTV-------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL---IA 5127
Query: 8038 QREEFETARDSILVWLTEMDLQLTN-----IEHFSECDVQAKIKQLKAFQQEISLNHNKI 8092
++E E ++L WL + LT+ I E +V+A I + + F +E++ +
Sbjct: 5128 KQELLE----ALLAWLQWAETTLTDKDKEVIPQEIE-EVKALIAEHQTFMEEMTRKQPDV 5182
Query: 8093 EQI 8095
+++
Sbjct: 5183 DKV 5185
Score = 286 bits (731), Expect = 8e-76
Identities = 864/4710 (18%), Positives = 1776/4710 (37%), Gaps = 672/4710 (14%)
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA-KEFSDKCK 3811
+E G+ + LE +A LR E+ + +E L+++ + V+++ + E L LA K
Sbjct: 538 KEWGKLIIAMLEREKA--LRPEV-ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK 594
Query: 3812 ALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----KSLQQTVLSHEPSVKSVREKGE 3866
L + ++ +A+++ Y L+Q V+ + + + +
Sbjct: 595 RLESGVQ----------------FQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQAD 638
Query: 3867 ALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH 3926
L++ V L+D+I L+++ + S G+ + E + +I
Sbjct: 639 QLVQRV--AKLRDEIMALRNECSSVYSKGRILTTE-------------QTKLMISGITQS 683
Query: 3927 LQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 3986
L + Q +H L T+ M L + ++ T + S + P
Sbjct: 684 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 743
Query: 3987 DLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQT 4046
+ +P + + Q++ +K++ D TE+
Sbjct: 744 NFSSGVEPNSLQTLKLMQIR-----------------------KPLLKSSLLDQNLTEEE 780
Query: 4047 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH---SELELNIAQNMVSQ 4103
I K VQ +++ ++E L + L+N K H E E ++ + +S+
Sbjct: 781 INMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 840
Query: 4104 VK----------DFVKKLQSKQASV---------------NTIIEKVNKL---TKKEE-- 4133
++ + + +L+S+ A + N + N+L +KEE
Sbjct: 841 IQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 900
Query: 4134 -----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY--------HDCMNVVEV 4180
S + I D +L R+ + Q+EE+++ ++ H +E
Sbjct: 901 VAYDWSERNTNIARKKDYHAELMRELD----QKEENIKSVQEIAEQLLLENHPARLTIEA 956
Query: 4181 FLEKFTTEWDNLAR-------------------SDAESTAVHLEALKKLALALQ-----E 4216
+ T+W + + +DA+ +L LK A+Q +
Sbjct: 957 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCD 1013
Query: 4217 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI----------- 4265
R +I L+D Q+ +E +KE + + S + + + +I+ K
Sbjct: 1014 RSSSIHKLEDLVQESME-----EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 1068
Query: 4266 ---------QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQS-----PPP----- 4306
Q+ +T ++ V + +W + P EA+ S PPP
Sbjct: 1069 PIKAICDYRQIEITIYKDDECVLANNSHRAKW-KVISPTGNEAMVPSVCFTVPPPNKEAV 1127
Query: 4307 DMAQNLLMDHLAICSELEAKQMLLKS------LIKDADRVMADLGLNERQVIQKALSDAQ 4360
D+A + + + + + +KS LI + DR+ A + + ++
Sbjct: 1128 DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPG------ 1181
Query: 4361 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4420
H LS+L + +L S+++Q VF + Q + K
Sbjct: 1182 EHQQVLSNLQSRFEDFLED--SQESQ----VFSGSDITQ------------------LEK 1217
Query: 4421 QVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCS 4480
+V CK + YQ EL+K +E+ E + ++Y S ++
Sbjct: 1218 EVNVCK------QYYQ-----------ELLKSAEREEQEE------SVYNLYISEVRNIR 1254
Query: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540
RL+ E L+ + + D L ++ + L E L L N E+
Sbjct: 1255 LRLENCEDRLIRQIRTPLERDD----LHESVFRITEQEKLKKELERLKDDLGTITNKCEE 1310
Query: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK---DKFYKVQE 4597
Q + +P+L +LN + + N + +++ DK V
Sbjct: 1311 --------FFSQAAASSSVPTLRS--------ELNVVLQNMNQVYSMSSTYIDKLKTVNL 1354
Query: 4598 AILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGE 4657
+ + +L++L L E EA + + E +S R+ +DE +
Sbjct: 1355 VLKNTQAAEALVKLYETKLCEEEAVIADKNNI------ENLISTLKQWRSEVDEKRQVFH 1408
Query: 4658 AVDELNQKKEGF----------RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707
A+++ QK + R W +K LV + + Q + R+ LE
Sbjct: 1409 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1468
Query: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767
+ + + L+ ++ V+ Q K+ +E P K +LA L +++ + +
Sbjct: 1469 SLKYYRDTYHPLDDWIQQVETTQRKI-QENQPENSK-----TLATQLNQQKMLVSEIEMK 1522
Query: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4827
+ +K Q + + +L T V + V+ Q+ +
Sbjct: 1523 QSKMDE------CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1576
Query: 4828 WLRRVKAELSGPVYLDL--------NLQDIQEEIRKIQIHQEE-VQSSLRIMNALSH--- 4875
++ + V L +L+ ++EE + ++ ++E V+ + + +S+
Sbjct: 1577 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1636
Query: 4876 --KEKEKFTK---AKELISADLEHSLAELSELDGDIQEALRTRQATLT--------EIYS 4922
K+ EK K +K+ IS++ E+S + EAL+T Q L E +
Sbjct: 1637 TLKDAEKAGKPPFSKQKISSE------EISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1690
Query: 4923 QCQRYYQVFQAANDWL-EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL--E 4979
+ ++ + Q + + L ++ + LQ + DV+ E+ + + + + Q +L +
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750
Query: 4980 ELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR 5039
+ L+ + + G +L++ + + + + +D L ++ K
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKK----YQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1806
Query: 5040 EEVIELMNDT--EKKLSEFSLLKTSSSHEAEEKLSE-HKALVSVVNSFHEKIVA---LEE 5093
E + + E+KL+E + + +AE+ E K + + + EK+ A LEE
Sbjct: 1807 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1866
Query: 5094 KASQLEK-------TGNDASKATLSRSMT-----TVWQRWTRLRAVAQDQE---KILEDA 5138
+++E D+ +A T +Q A+ ++ E +LE
Sbjct: 1867 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1926
Query: 5139 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5198
VD +V E ++Q K+ KA+ ++ H ++ QSA
Sbjct: 1927 VD------GQVGTTQENLNQQYQKV---------KAQHEKIISQHQAVIIAT---QSAQV 1968
Query: 5199 MLRQQTLSMLQDGAAPTPGEEPPL---MQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5255
+L +Q G +P E+ L M+E+ + L EK +++EL E
Sbjct: 1969 LLEKQ-------GQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---E 2018
Query: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL 5315
+ + W+Q++++ L N ++A +++ L+T+ + E + + + L
Sbjct: 2019 KFDADYTEFEHWLQQSEQELEN----LEAGADDINGLMTKLKRQKSFSEDVISHKGD--L 2072
Query: 5316 GLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILT 5375
TI + ++ E A RD +V+ S AT +E+ R++ ++ +
Sbjct: 2073 RYITISGN----RVLEAAKSCSKRDG-----GKVDTS-ATHREVQRKLDHATDRFRSLYS 2122
Query: 5376 KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435
K +N+ + + G + L +A K L + + ++ + T+
Sbjct: 2123 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2182
Query: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495
Q I + + KL + A L + L I+K G S S + E+
Sbjct: 2183 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS-VNERN 2241
Query: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5555
Q L S + L+ M L ++ +V + K QV + L+ +I +
Sbjct: 2242 EKLQITLTRSLSVQDGLDEM---LDWMGNVESSLKEQGQVP---LNSTALQDIISKNIML 2295
Query: 5556 LQDAAKDMKKFEAELKKLQAALEQAQ-ATLTSPEVGRLSLKEQLSHRQH----LLSEMES 5610
QD A A +K++ +E +T +S + L + S H L++ME
Sbjct: 2296 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2355
Query: 5611 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5670
LK KV+ + + E + L AL + + T + Q MQ + ++
Sbjct: 2356 LKTKVELFE------NLSEKLQTFLETKTQALT-EVDVPGKDVTELSQ--YMQESTSEFL 2406
Query: 5671 QYEQEMKHLQQLIE--GAHREIEDKPVATSNIQELQAQISRHE----ELAQKIKGYQEQI 5724
++++ ++ L L++ +H DK + L + E E + + QEQ+
Sbjct: 2407 EHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2466
Query: 5725 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 5784
+ K L K T + + + + G EDL L T + T
Sbjct: 2467 DAFQVLVKSLKSWIKETTKKVPIVQP---SFGAEDLGKSLEDTKKLQEKWSLKTP----- 2518
Query: 5785 LLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIH 5844
++ NS IS + + A A+V A L+ E T+
Sbjct: 2519 --------EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA---VLNGEGTATN----- 2562
Query: 5845 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5904
++EF+ S + D+ +E L ++ +K L L + QK Q+ ++
Sbjct: 2563 -----TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2617
Query: 5905 ST---KMEAIELKLSESPEPG--RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
KM K ++P P + ++Q+ ++++ E+ +++ EL+ L E L+
Sbjct: 2618 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE-LLE 2676
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRC 6019
E+ D E + LT + + + ++Q LEE N+ + Q E L++
Sbjct: 2677 EN--PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ--- 2731
Query: 6020 EADELDSWLLSTKATLDTALSPPK-EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
WL+ K + + L P +P + Q Q +L E + +L+ +
Sbjct: 2732 -------WLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2783
Query: 6079 LLLEG------KAHTKDEAEQLAGKLRRLKGSLLEL-----QRALHDKQLNMQGTAQEKE 6127
+L + K++ + K L G L + Q + Q + +
Sbjct: 2784 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2843
Query: 6128 ESDVDLTATQSPGVQ---EWLAQARTTWTQQRQSSLQQQKELE--QELAEQKSLLRSVAS 6182
SD+D + S V + + Q T + +Q Q++K+++ Q L E S L
Sbjct: 2844 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2903
Query: 6183 RGEEILIQ-HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR---MKWESLHQE---- 6234
E+ Q ++ D +K + Q L S QM W +E
Sbjct: 2904 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2963
Query: 6235 ---FSTKQKLLQNVLEQEQ-------------EQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S K +L+++++ + E+ + N LL K + Q +
Sbjct: 2964 SHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 3023
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLF-VATALL 6337
T+ D N+ +E ++ ++S+ K + V W+D + L + L
Sbjct: 3024 IKTNW-DTFNKQVKERENKL----KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 3078
Query: 6338 PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL 6397
P E E + + L K++ + ++ N + +++V+ D L+ ++ ++
Sbjct: 3079 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 3138
Query: 6398 DSVVNQRCHQMKERLQQILNFQNDLKV-----------------LFTSLADNKYIILQKL 6440
++ + ++ Q+ FQ K L + NKY+ + +
Sbjct: 3139 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3198
Query: 6441 ANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 6499
Q + Q++ ++ A+D + E + K D L + QE S L DE
Sbjct: 3199 QQKSLQALKHQVDLAKRLAQDLVVEAS----DSKGTSDVLLQVETIAQEHSTLSQQVDEK 3254
Query: 6500 MMIIGSRRSGL----NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL 6555
+ ++ G+ N + SQ+ +L + G+ D + + KE I+
Sbjct: 3255 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-----DAETLQKQKETIKAF 3309
Query: 6556 LDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR 6609
L K + ++ M+ TE ++ E L Q + +L RA R
Sbjct: 3310 LKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA-----LSKQCNKLLDRAQAR 3364
Query: 6610 GVELEYIL----ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665
++E + E +S L E L + E ES P VG+ E ++ ++ ++Q K
Sbjct: 3365 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGP-VGMETETINQQLNMFKVFQ--K 3421
Query: 6666 SSLNEYQPKLYQVLDDGKRLLISI----SCSDLESQLNQLGECWLSNTNKMSKELHRLET 6721
+ Q K V G+ L+ S S LE L+ + W + K+++ +L+
Sbjct: 3422 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3481
Query: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
L H R+Q L+ W+ ++ + S E ++V+ + + +D +
Sbjct: 3482 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVKAQIQEQKLLQRLLDDR 3537
Query: 6782 SSLKSSVLSTGNQLLRLKK-VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
S + G ++ + D + +LS +DS+W LL +L + +
Sbjct: 3538 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3597
Query: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDI---NCKQLT 6895
+ + W++ +E + E IG +A + E + ++K + DI N
Sbjct: 3598 FHETLEPLNEWLTTIEKRLVNCEP-----IGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3652
Query: 6896 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQI-LQGLVTEKIQLLEGLLESWS 6954
+ QS+ +SS++ + K DF++ W I +Q + +LL+ L +
Sbjct: 3653 AVSIGQSLKVLSSREDKDMVQSKLDFSQV-------WYIEIQEKSHSRSELLQQALCNAK 3705
Query: 6955 EY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013
+ E+ V+ + E +K K + + + + L++ I +++ V++ N
Sbjct: 3706 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3765
Query: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073
GL L++ D I+ L + + ++ + + L+ L +++ +
Sbjct: 3766 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3825
Query: 7074 YLMEARYSLSRF--RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
+L + L + ++L G EA Q Q+ + L+ + + + L +++ LL+
Sbjct: 3826 WLDKVEVELLSYETQVLKGE-EASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLELVP 3883
Query: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
E L + E N R+ + + I ++++ A + Q++ + S + + E +
Sbjct: 3884 WRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL 3943
Query: 7192 NELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAI 7251
L +D ++ ++L+ + D + H++ ++ S +
Sbjct: 3944 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 4003
Query: 7252 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 7311
L +C + Q Q+ V F ++ E L W+ E + I+ Q P+
Sbjct: 4004 DK-VLKNYDTICQINSERYLQLERAQSLV---NQFWETYEELWPWLTETQSIIS-QLPAP 4058
Query: 7312 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-PLNDKEIKRMQN----LNRHW 7366
+ + T++++ EE + + P +D++N+ G +L L+ E +Q + +
Sbjct: 4059 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY 4118
Query: 7367 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQR 7424
S I +R L + Q F +K + +E L + ++L IS + + EQ
Sbjct: 4119 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQIS 4178
Query: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRA 7480
++ +M Q + ++ G+ ++ + D+D KL + W+ +
Sbjct: 4179 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4238
Query: 7481 QQRRG----IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ--ARTLFD 7534
++R +++ + W + + ++ + L G+ + QQ A T+ +
Sbjct: 4239 EEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4298
Query: 7535 EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQK 7594
E+ Q + + G +L+ + + ++ + E+ W S + +++
Sbjct: 4299 EID-------GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4351
Query: 7595 KKLAFLLK-------------DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE---ELHA 7638
KL ++ DW G S+ + T + + Q + + + E +
Sbjct: 4352 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4411
Query: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
+Q+ + L + Q LL L D + + + L+ W+ L ++
Sbjct: 4412 QQIEMERLNH----------QAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERII 4458
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN----GDILIEEMIEKLKKDYQEE 7754
R+ ++ L F EL WLT E +S+ GD E IE K +
Sbjct: 4459 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE-IELAKHHVLQN 4517
Query: 7755 IAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+A ++ ++ + + G L ++S +AS ++ KL +N RWQ++L+ R ++L L
Sbjct: 4518 DVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4577
Query: 7814 VAVQQLDKNMSSLRTWLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ + L+ WL E L +KP+ E + +LN E+ E
Sbjct: 4578 RQAKGFHGEIEDLQQWLTDTERHLLASKPL---GGLPETAKEQLNVHMEVCAAFEAKEET 4634
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
S++ + +L C A +I Q NL +W ++ ER+ K+EE L
Sbjct: 4635 YKSLMQKGQQMLARCPKSAET----NIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4690
Query: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
+F + F +WL +E+T S +I ++ + + F +V+ Q+ ++K
Sbjct: 4691 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4750
Query: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
L ++ +K ++ RW+ + +R+ R L + ++F A ++
Sbjct: 4751 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4810
Query: 8052 WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL 8109
WL E + L + +E ++ D ++ ++ Q K FQ+ + H+ + G L EK+
Sbjct: 4811 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4870
Query: 8110 DAAI-IEEELDELRRYCQEVFGR-VERYHK 8137
D + +++ L ELR + G+ VER +K
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNK 4900
Score = 278 bits (712), Expect = 1e-73
Identities = 768/4289 (17%), Positives = 1650/4289 (38%), Gaps = 539/4289 (12%)
Query: 1285 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1344
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1183 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1242
Query: 1345 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1394
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1243 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1299
Query: 1395 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1454
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1300 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1358
Query: 1455 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1514
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1359 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1414
Query: 1515 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1547
Q S F T E +I +L + G+ L+ +
Sbjct: 1415 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1474
Query: 1548 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1604
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1475 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1527
Query: 1605 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664
CQ SA K + A QQ + RR Q++ + ++ +
Sbjct: 1528 ECQKYAEQYSATV-------KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEF 1578
Query: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEVVSQASFYSKL 1723
L ++ +T + + + + D +K +E E + ++ + E V +A K
Sbjct: 1579 MDLRTRYTALVTLM--------TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA----KE 1626
Query: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
LQ S S KD K K P ++I+ + + + +Q E L +
Sbjct: 1627 LQKWVSNISKTLKDAEKAGK-------------PPFSKQKIS-SEEISTKKEQLSEALQT 1672
Query: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
I+LFL+ +H D + E + EL+ L + +L +
Sbjct: 1673 ----IQLFLA------------------KHGDKMTDEE--RNELEKQVKTLQESYNLLFS 1708
Query: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNS 1903
E L LQ +++ + E V ER+Q + L GI L QT
Sbjct: 1709 ESLKQLQ-ESQTSGDVKVEEKIVAERQQ----------EYKEKLQGICDLLTQT------ 1751
Query: 1904 MNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLC 1963
E+ LI Q A + V L SK + E + + +A L
Sbjct: 1752 ----ENRLI------GHQEAFMIGDGTVELKKYQSKQE--------ELQKDMQGSAQALA 1793
Query: 1964 GEVERIQNLL---GTKQSEADALAVLKKAFQDQK---EELLKSIEDIEERTDK---ERLK 2014
V+ +N L G K S+ D A++++ + K E+L E ++ DK +K
Sbjct: 1794 EVVKNTENFLKENGEKLSQEDK-ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 1852
Query: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKD----------KAKQIAQKD-------- 2056
E T +++ QLE+ E+ L WL + K KQ+ +++
Sbjct: 1853 EET-----EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGD 1907
Query: 2057 --VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
A E + N LE D EN L ++YQ +K+ K++ +
Sbjct: 1908 GKSAIGEEDEVNGNLLETDVDGQVGTTQEN---------LNQQYQKVKAQHEKIISQHQA 1958
Query: 2115 VIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLD-NFTSKGKHLLSELKKIHSSDFSL 2173
VI+ + + + + + E K K+ K+L ++ + ++K HS L
Sbjct: 1959 VIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 2017
Query: 2174 VKTDMEST-VDKWLDVSEKLEEN-----------MDRLRVSLSIWDDVLSTRDEIE--GW 2219
K D + T + WL SE+ EN M +L+ S +DV+S + ++
Sbjct: 2018 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 2077
Query: 2220 SNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETP 2278
S N V + A++ S D + +E + ++ + R L+SK N L K
Sbjct: 2078 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----- 2132
Query: 2279 PDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA 2338
DL+ K +H + + + G L A K +++ K
Sbjct: 2133 --------DLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPIAVDPK--------- 2172
Query: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQENLNSL--CRKYHSAELESLGRAMTGLIKKH 2396
L++ K +Q ++ SQQ + ++ L R + + + ++ ++
Sbjct: 2173 --NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2230
Query: 2397 EAVSQLCSKTQASLQESLEKHFS--ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
E +S+ ++ LQ +L + S + + E +W +++ KE +S L+ +
Sbjct: 2231 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2290
Query: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
+ ++ QS ++A+ ++ + SS+Q ++ + F + +
Sbjct: 2291 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2350
Query: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----ENLGESKQHIPEKKNEV--HKV 2567
+++ +++ FE+ KL ++ + +++ E Q++ E +E HK
Sbjct: 2351 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2410
Query: 2568 EM-FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSC 2626
+ L LL S S + +L + + S+ ++ ++ KE + SC
Sbjct: 2411 HLEVLHSLLKEISSHGLPSDKALVLEKTNN--------LSKKFKEMEDTIKEKKEAVTSC 2462
Query: 2627 QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGE 2683
Q L + L ++L+S W+K ++ + + G++D L K L ++Q+ +K
Sbjct: 2463 QEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAED-LGKSLEDTKKLQEKWSLKTP 2518
Query: 2684 GEVKLN----------MAIGKGEQALRSSNKEGQRVIQTQ--LETLKEVWADIMSSSVHA 2731
K+N A+ +A+ ++ K G V+ + +E WA+ +S+
Sbjct: 2519 EIQKVNNSGISLCNLISAVTTPAKAI-AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2577
Query: 2732 QST-------------------LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ-PQP 2771
T L + +S+ E + + QW++ +++ Q P P
Sbjct: 2578 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2637
Query: 2772 GLKEKF-VLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE---ELKTQ 2827
E ++ +S +E + + + L K EL E+ D ++ E+ ++
Sbjct: 2638 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2697
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
+ ++ + ++ +K+EE + + + WL + + +S D + +
Sbjct: 2698 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2757
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTA-SGCELMHTEMQALRADWKQWEDSVFQ 2946
+++ L L + P+ +Q T A G E +LR K+ +V Q
Sbjct: 2758 QQVQIL----------LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2807
Query: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSALLKTWAQQLTLLEGKNTDEEIV 3003
L + S + ++QA+ Q+ +LL++ + +L+ L+ K + V
Sbjct: 2808 KWDSLTG----------QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2857
Query: 3004 ECWHKG-QEILDALQKAEPRTEDLKSQLNELCRFSRDLST----------YSGKVSGLIK 3052
+ L+ QK + + K Q+ DLS S ++ G++K
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2917
Query: 3053 EYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS 3110
+ + +A Q+ + +F++ RDFQ WL K K I + + +
Sbjct: 2918 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2977
Query: 3111 LQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQ 3170
++ ++F H +++GE L + +Q ++ K +W F+ + +
Sbjct: 2978 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 3037
Query: 3171 KESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI 3230
+E+ L+ + ++ E + W+ K + + E L D KL+S+ +E+
Sbjct: 3038 RENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCL-DPAEGENSIAKLKSLQKEM 3096
Query: 3231 HCYEPQLNRLKEKAQQLW------------EGQAASKSFRHRVSQLSSQYLALSNLTKEK 3278
+ + L A L E ++ + QL S+ L N+T +K
Sbjct: 3097 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT-QK 3155
Query: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIH-MLDSYCHPTSDKSVLDSRTLKLEALL-SV 3336
+ E + KE D IH L S + ++L ++ L+AL V
Sbjct: 3156 FKEFQEVSKESKRQLQCAKEQLD-----IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV 3210
Query: 3337 KQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396
K + ++V +S +G + Q++++ ++L S LE L
Sbjct: 3211 DLAKRLAQDLVVEASDS-------KGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3263
Query: 3397 KWTSYQDGVR----QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSL 3452
+Q+ +R QF+ + D +++ + K T+ K L + S +
Sbjct: 3264 GIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNA 3323
Query: 3453 LETIEVKGAGMTEHYVTQL-----ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507
+T ++ A TE L +L+ L ++ + +RA+ + E ++ +E+
Sbjct: 3324 NKTCKMMLA--TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3381
Query: 3508 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE------------GQAL 3555
LK F + L + +E + + + T L + Q E GQ L
Sbjct: 3382 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3441
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ S S Q + L+ + W+ ++++ Q + + +
Sbjct: 3442 IQS-------AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3494
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
+ W+ EE +++ + +V + + Q++L + + + + A
Sbjct: 3495 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATT 3554
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
+ +++K L +++ L+ +L + ++ + VA + +TL
Sbjct: 3555 AEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-----------ETL 3602
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEE-GEAERLRKEIHDHMEQLKELTSTVRKEHM 3794
E L + + L + G +A K E+ + + L +I +H + L H
Sbjct: 3603 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL----------HQ 3652
Query: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3854
+ G L S + K + Q ++ ++ ++ E+ EK S+ + LQQ +
Sbjct: 3653 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI------EIQEKSH--SRSELLQQALC-- 3702
Query: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG--------KAMMEEIAGFE 3906
+ K E L+ + +V DK+ +L QD + G + + E+I +
Sbjct: 3703 --NAKIFGEDEVELMNWLNEV--HDKLSKL--SVQDYSTEGLWKQQSELRVLQEDILLRK 3756
Query: 3907 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 3966
++ + G L+ Q ++ + A KD A+ + Q+L+ +
Sbjct: 3757 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3816
Query: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4026
H T ++ WL V+ +L L EA + + L+++A+ LL S+
Sbjct: 3817 H----STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3872
Query: 4027 DLSNASVKTTAKDIQQ-----TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQ 4081
++S+A ++ ++ + E+ + + +TQ EEI + Q AD +
Sbjct: 3873 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3932
Query: 4082 L----QNMKRRHSELELNIAQNMVS---QV-KDFVKKLQSKQASVNTIIEKVNKL----T 4129
L + K+ S ++ + Q+ S QV K F ++ + ++ +++ +K+ +
Sbjct: 3933 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3992
Query: 4130 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4189
++E+ K+++ + + +C+ ++ LQ E ++V F E + W
Sbjct: 3993 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLER----------AQSLVNQFWETYEELW 4042
Query: 4190 DNLARSDAESTAVHLEALKKLALALQERKY-AIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248
L + + + + AL+ L Q+ ++ + +L + + I+ +N +L++
Sbjct: 4043 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 4102
Query: 4249 H---LEQRWFQLEDL---IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302
+++++ + L IK ++ L+E ++F + ++ E I E L+Q
Sbjct: 4103 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 4162
Query: 4303 SP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
P + + + ++ + ++E Q L ++L + + ++A G ++ + KA+ D
Sbjct: 4163 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4222
Query: 4359 AQSHV----NCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
+ + LV +R L + +F I+ + I E +
Sbjct: 4223 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4282
Query: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
P V +Q + ++ + + Q E+ + G EL+ E +K V + EL S +DS
Sbjct: 4283 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4342
Query: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT---QL 4531
+ + R+ +LE+ + + +++ W+ DI ++ ++L T Q+
Sbjct: 4343 LNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV---DIAGGKLASMSPIGTDLETVKQQI 4399
Query: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKD 4590
+ + ++ + + + L + +L + E D + + L L ++ + +
Sbjct: 4400 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4459
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD-LAVEEALS----LQDGC 4645
+ +K++ A+LA ++ ++ L+ E V D A+E L+ LQ+
Sbjct: 4460 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
A V + +A ++L + G ++ +K+ L + + +TEQR L+
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4576
Query: 4706 TSAYQEHEKMCQQLERQLKSVKEE---QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK 4762
+ + L++ L + + A+E+L ++ + + + K
Sbjct: 4577 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4636
Query: 4763 RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEM 4822
+ + + A I + + + + + + + E T+ E + +++F +
Sbjct: 4637 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4696
Query: 4823 SRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEK 4880
++WL + + L+ L L + +I + ++ EV S + L + +
Sbjct: 4697 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4756
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
F++ ++++ +++ L + + + L R +L + + +++++ + +WLE+
Sbjct: 4757 FSQKQDVVL--IKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4814
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTG 4996
+++ L + L++ + + +K+ + + +F +L HS+ T + L + T
Sbjct: 4815 SEKSLD---SELEIANDPDKIKTQL---AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTS 4868
Query: 4997 KED----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKK 5052
D L+ ++ L + + S + + L+ + A + +I+ + E +
Sbjct: 4869 LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ 4928
Query: 5053 LSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSR 5112
L+E + + HKA + + AL+ A +L + D S + +
Sbjct: 4929 LAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKV 4986
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
M + RW + A++ ++ LE A+ + F++ V E + + + L
Sbjct: 4987 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 5046
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
+ L TL++ H F+ +LE++++ L ++L A P + IT ++ R
Sbjct: 5047 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL---AICHPDSITTIKHWITIIRAR 5103
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ--------ETKEYLGNPTIEIDA 5284
+ K + + + L + + ++ W+Q + KE + E+ A
Sbjct: 5104 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 5163
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEK 5313
+ E Q + E T + +++K+ + K +
Sbjct: 5164 LIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5192
Score = 276 bits (707), Expect = 5e-73
Identities = 777/4352 (17%), Positives = 1650/4352 (37%), Gaps = 709/4352 (16%)
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQ----ADEMDRMKKEYTDCVVTL-----SAFATEAHK 736
++QQ + W E + +K +E+DR++ + T+ +
Sbjct: 1133 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1192
Query: 737 KLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
+ + LE S + D+ +E+ V V Y+ + K+A +E +E ++ +
Sbjct: 1193 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE---REEQEESVYNLY--I 1247
Query: 797 SKLKEQLTKVKECYSPL------------LYESQQLLIPLEELEKQMTSFYDSLGKINEI 844
S+++ +++ C L L+ES + E+L+K++ D LG I
Sbjct: 1248 SEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNK 1307
Query: 845 ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD---- 900
+A +S+ EL +N + ++ S + K T++ VLK+
Sbjct: 1308 CEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSM---SSTYIDKLKTVNLVLKNTQAAEA 1364
Query: 901 -----QTRLQRQ---IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRI 952
+T+L + IAD + ++++ W+ V+ ++ E+ EL+K I
Sbjct: 1365 LVKLYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALED---ELQKAKAI 1420
Query: 953 AQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDI--------LPEQEQQGL 1004
+ E + + + H E QL +R N ++ + L D+ L
Sbjct: 1421 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPL 1480
Query: 1005 QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLAS-VEECRTELDRETKLMPQEGS-- 1061
+ ++++ + +Q P + L + + + L S +E ++++D K Q +
Sbjct: 1481 DDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV 1540
Query: 1062 ---EKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVK--LPVRDPVRDTPGTCHVTL--KE 1114
E +R + + +R+Q +L ++ + +R T T VTL +
Sbjct: 1541 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR-----TRYTALVTLMTQY 1595
Query: 1115 LRAAIDSTYRKLMEDP---DKWKDYTSRFSEFSSWISTNETQLKG-------------IK 1158
++ A DS R E+ ++ K++ + E W+S LK I
Sbjct: 1596 IKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1655
Query: 1159 GEAIDT----------------ANHGEVKRAVEEIRNGVTKRGETLS-----WLKSRLKV 1197
E I T A HG+ + +E RN + K+ +TL LK
Sbjct: 1656 SEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERNELEKQVKTLQESYNLLFSESLKQ 1713
Query: 1198 LTEVSSENEAQKQGDELAKLSSSFK----ALVTLLSEVEKMLSNF--------------- 1238
L E + + + + +A+ +K + LL++ E L
Sbjct: 1714 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKK 1773
Query: 1239 -------------GDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEA----QQL 1281
G E+VKN+ E + + E Q +K L + L EA +QL
Sbjct: 1774 YQSKQEELQKDMQGSAQALAEVVKNT-ENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1832
Query: 1282 LLHHQQKTKR----ISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRER 1337
L +Q K ++ ++ +++A +Q E E K+E+ LD L +
Sbjct: 1833 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE--------ESKTKIENLLDWLSNVDKD 1884
Query: 1338 QER----RIQVTLRKWERFETN--------KETVVRYLFQTGSSHERFLSFSSLESLSSE 1385
ER QV + F+ ++ V L +T + ++ E+L+ +
Sbjct: 1885 SERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ---VGTTQENLNQQ 1941
Query: 1386 LEQTKEFSKRTES------IAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439
++ K ++ S IA Q+ ++ E L P+ K+ LQ+ K +K +
Sbjct: 1942 YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 2001
Query: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK----- 1494
E+ +K ++ + + F +++ W+ + E+EL LE + ++ ++++K
Sbjct: 2002 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 2061
Query: 1495 ---VTIQEIESKLSSIVG--LEEEAQSFA-----QFVTTGESARIKAKLTQIRRYGEELR 1544
V + + + +I G + E A+S + + T+ ++ KL L
Sbjct: 2062 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 2121
Query: 1545 EHAQCLEGTILGHLSQQQKFEE-------NLRKIQQSVSE-FEDKLAVPIKICSSATETY 1596
L + + + Q +E+ L+ + + S+ + +AV K E
Sbjct: 2122 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEET 2181
Query: 1597 KVLQEHMDLCQ-ALESLSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQ 1654
K LQ + Q A+E L + ++ + +Q+ + +YED+ + ER
Sbjct: 2182 KALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERN 2241
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
L+ L ++ L L W+ E+ +K +G++ L +++
Sbjct: 2242 EKLQITLTRSLSVQDGLDEMLDWMGNVESS------------LKEQGQVPLNSTALQDII 2289
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKMMKL----HLEQLDERWRDLPQIINKRINFLQSV 1770
S+ + + ++S + ++ K M+ L + +DL ++ + +
Sbjct: 2290 SKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2349
Query: 1771 VAEHQQFD---ELLLSFSVWIKLFL-SELQTTSEISIMDHQVA-LTRH-KDHAAEVESKK 1824
+A+ ++ EL + S ++ FL ++ Q +E+ + V L+++ ++ +E K
Sbjct: 2350 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2409
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSH 1884
L+ L L ++ S G D L+ K + + F+E ++ ++ A++ E L +
Sbjct: 2410 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2469
Query: 1885 ASLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKALE--------------SA 1929
L ++ L+ + E T + + +DL +L++ K L+ ++
Sbjct: 2470 QVL---VKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2526
Query: 1930 AVSLDGILS------KAQYHLKIG-----------------SSEQRTSCRATADQLCGEV 1966
+SL ++S KA +K G +++ TS + +
Sbjct: 2527 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2586
Query: 1967 ERIQNLLGTKQSEADA-LAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPT-RQALQQ 2023
E + LL K +E + L+ L+KA Q++ +++ ++ + + K ++ PT +A++
Sbjct: 2587 EDLGLLLKDKIAELNTKLSKLQKA-QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2645
Query: 2024 RLRVFNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRLI 2081
++ E EL + +++ LKDK ++ ++ D AP + + ++ W + +L
Sbjct: 2646 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2705
Query: 2082 HENQGQCCGLIDLMREYQNLKSAVSK-VLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ Q + + + ++Q +++ + + ++E V V D L + +
Sbjct: 2706 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2765
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLR 2200
+ ++ + T+ G+ +LS + S +VK + + KW ++ +L + D +
Sbjct: 2766 EFATRKPQYEQLTAAGQGILSRPGE-DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWID 2824
Query: 2201 VSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE--------------ELLKE 2246
++ V ST+ + + + +++ +S+LDN L + E ++
Sbjct: 2825 QAI-----VKSTQYQ------SLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2873
Query: 2247 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLE----HAKEITEVA 2302
+ E++ + +++ + DL L K ++++A+L ++LE K++ + A
Sbjct: 2874 MKQEIQQEKKQIKVAQALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKA 2926
Query: 2303 KG---TLKDFTAQSTQVEKFINDITTWF-TKVEESLMN---CAQNETCEAL-KKVKDIQK 2354
+ L+ A S Q ++ D W TK EE + A+ + E+L K KD K
Sbjct: 2927 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2986
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
L +Q T +L K +E +L + + + ++ + + L+ESL
Sbjct: 2987 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 3046
Query: 2415 EK--HFSESMQEFQEWFLGAKAAAKE----SSDRTGDSKVLEAKLHDLQNILDSVSDGQS 2468
EK + E ++ W + +E G++ + AKL LQ +D G
Sbjct: 3047 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI--AKLKSLQKEMDQ-HFGMV 3103
Query: 2469 KLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFE 2528
+L T + K++V+ + + ++ +Q K L++ + F+
Sbjct: 3104 ELLNNTANSLLSVCEIDKEVVTDENKSLI---QKVDMVTEQLHSKKFCLENMTQKFKEFQ 3160
Query: 2529 DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRG 2588
+ ++ + +E+ + + S+ + + + + L L + +L+Q
Sbjct: 3161 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3220
Query: 2589 QLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2648
+ + + G + H L + EK + LQ + ++ M+
Sbjct: 3221 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3280
Query: 2649 AIQDRLAC-------AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQA--- 2698
D L AE+ K+T++ L +++ ++ M + E +
Sbjct: 3281 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3340
Query: 2699 ------LRSSNKEGQRV----------IQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
L + +K+ ++ ++ ++ L+E ++ + S+ Q E SQ
Sbjct: 3341 VGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3400
Query: 2743 NDYVERKNQLEQW-MESVDQKIE-HPLQPQ--------PGLKE---KFVLLDHLQSILSE 2789
+E + +Q M V QK E PLQ + GL + K L+ L +
Sbjct: 3401 PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3460
Query: 2790 AEDHTRALHRLIA-KSRELYEK-TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE-EIV 2846
+ L++ +A ++ +L E F+D + L + VA +K E ++V
Sbjct: 3461 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3520
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKE--LIDSR------- 2897
K + + D S E + R + ++ K+ +K+ L+DSR
Sbjct: 3521 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3580
Query: 2898 -EIGASRLSRV--------ESLAPEVKQNTTAS----GCELMHTEMQALR---ADWKQWE 2941
E +L + E+L P + TT CE + T+ L A K E
Sbjct: 3581 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3640
Query: 2942 DSVFQTQSCLENLVS--------------QMALSEQEFSGQVAQLEQALEQFSALLKTWA 2987
D + L VS M S+ +FS QV +E + S ++
Sbjct: 3641 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS-QVWYIEIQEKSHS---RSEL 3696
Query: 2988 QQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR---TEDLKSQLNELCRFSRDL---- 3040
Q L K E+ VE + E+ D L K + TE L Q +EL D+
Sbjct: 3697 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3756
Query: 3041 ----------------------STYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ--QRF 3076
K+ + Y + ++ + EQ LQ +R
Sbjct: 3757 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3816
Query: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136
+ WL ++ E S + + +E E++N + L+ +
Sbjct: 3817 HSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3876
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
L L+ +G++ V E ++ + QK ++ ++ + F+ +A+ W+
Sbjct: 3877 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3936
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE------- 3249
++TEK +L L R EQ + + L+ + ++ R K+ L +
Sbjct: 3937 TETEK-------KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3989
Query: 3250 --GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3307
+ +S + ++ ++ Y + + E+ +L+R + NQF +EL W+T+
Sbjct: 3990 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 4049
Query: 3308 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3367
++ P + L + + L + E + + + G +L+ + EG +IQ
Sbjct: 4050 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF-SIQ 4108
Query: 3368 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3427
++ + +++ + + L+ A+S+ T + D + Q L ER
Sbjct: 4109 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI----------LESLERIVE 4158
Query: 3428 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3487
LR ++ + + + E++ +E+ ++++ LQ Y +++R
Sbjct: 4159 RLRQPPSISAEVEKIKEQI-----------------SENKNVSVDMEKLQPLYETLKQRG 4201
Query: 3488 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHT----HETTLRDLQ 3543
+E + +S +D+ A V Q+KLDQ + + HT E L D+
Sbjct: 4202 EEMIARSGGT-------DKDISAKAV-----QDKLDQMVFIWENIHTLVEEREAKLLDVM 4249
Query: 3544 EL-QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
EL + + +L+ ++ T++ + P + ++ ++ + + + + + +
Sbjct: 4250 ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDI 4309
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC 3662
V+N E+ A E ++ ++ +DE
Sbjct: 4310 VIN-----------------------LGSELIAACGEPDK--PIVKKSIDE--------- 4335
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
L S + +L ++I LEE +Q+ + + L + DW +++
Sbjct: 4336 ----LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP---- 4387
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER----AVKYLEEGEAERLRKEIHDH 3778
+G L+T++ ++++++ S + + ER A L++ E + + D
Sbjct: 4388 -----IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP 4442
Query: 3779 MEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMEL 3834
+ +LK L + LE L +F L W+ + +L + +
Sbjct: 4443 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4502
Query: 3835 YEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL---VQDVTLKDKIDQLQSDYQDL 3891
+ +L+K+ LQ VL+H+ +V++V + G L+E + L++K++ L +Q++
Sbjct: 4503 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4562
Query: 3892 CSIGKAMMEEI-------AGFEDRLNNLQ------------------------------- 3913
+ +++ GF + +LQ
Sbjct: 4563 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4622
Query: 3914 -----------------MKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
KG ++ +C + + Q+++ K+ + ++ +
Sbjct: 4623 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN----NLKEKWESVETKLNER 4678
Query: 3957 YQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQAR 4016
LE L + ++LQ WL+ + L + +P L + Q+ + +
Sbjct: 4679 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN 4738
Query: 4017 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQ 4076
++ + + + D + +K ++ +Q I+ L+ Q+ WE++ E L
Sbjct: 4739 SHREQIIEL-DKTGTHLKYFSQ--KQDVVLIKNLLISVQS---RWEKVVQRLVERGRSLD 4792
Query: 4077 DADQQLQNMKRRHSEL-------------ELNIA------QNMVSQVKDFVKKLQSKQAS 4117
DA ++ + S+L EL IA + ++Q K+F K L +K +
Sbjct: 4793 DARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSV 4852
Query: 4118 VNTIIEKVNKLTKKEESPEHK-----EINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYH 4172
+T L +K + ++ L D+W +C +S + EE L + +
Sbjct: 4853 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4912
Query: 4173 DCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK 4230
D + + +L + + D D + ++ K L +R +++ LK ++
Sbjct: 4913 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4972
Query: 4231 MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAE 4290
+IE + DD VK Q L RW + L K L + S L+EW
Sbjct: 4973 LIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 5031
Query: 4291 EQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNE-- 4348
E + + D + L+ H +LE K+ L D V+A +
Sbjct: 5032 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSIT 5091
Query: 4349 ---------RQVIQKALSDAQSH----VNCLSDLVGQRR---------KYLNKALSEKTQ 4386
R ++ L+ A+ H + L+ L+ ++ ++ L++K +
Sbjct: 5092 TIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDK 5151
Query: 4387 FLM--AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEV----- 4439
++ + + + I +H+ F E + DV K KT K A + Q+ +
Sbjct: 5152 EVIPQEIEEVKALIAEHQ---TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDK 5208
Query: 4440 ----------TGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
+ L+ G + E + ++ K Q++ + +K + L LE+
Sbjct: 5209 GRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEE- 5267
Query: 4490 LVSRKHFKEDFD----KACHWL--KQADIVTF 4515
R+ DFD K W+ K++ ++ F
Sbjct: 5268 --LREFANFDFDIWRKKYMRWMNHKKSRVMDF 5297
Score = 270 bits (691), Expect = 4e-71
Identities = 840/4709 (17%), Positives = 1807/4709 (38%), Gaps = 678/4709 (14%)
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1434
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 807 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 862
Query: 1435 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1494
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 863 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 916
Query: 1495 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1548
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 917 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 973
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1603
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 974 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 1029
Query: 1604 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1653
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 1030 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 1089
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1712
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 1090 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 1147
Query: 1713 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1761
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 1148 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1199
Query: 1762 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1821
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1200 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1251
Query: 1822 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1880
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1252 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1311
Query: 1881 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1934
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1312 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1368
Query: 1935 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1991
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1369 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1411
Query: 1992 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2045
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1412 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1463
Query: 2046 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2101
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1464 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1518
Query: 2102 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1519 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1575
Query: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1576 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1631
Query: 2221 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2267
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1632 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1691
Query: 2268 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2327
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1692 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1748
Query: 2328 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2383
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1749 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1808
Query: 2384 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2437
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1809 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1867
Query: 2438 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2464
+ S+R G +V+E Q N+L++
Sbjct: 1868 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1927
Query: 2465 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2494
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1928 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1987
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1988 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 2045
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2612
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 2046 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 2096
Query: 2613 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2668
+ +E R A +L + +K + D+ E L E
Sbjct: 2097 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2156
Query: 2669 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 2157 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2216
Query: 2729 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2217 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2273
Query: 2789 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2825
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2274 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2333
Query: 2826 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2881
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2334 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2393
Query: 2882 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2941
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2394 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2449
Query: 2942 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2980
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2450 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2507
Query: 2981 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2508 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2566
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2567 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2620
Query: 3087 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3143
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2621 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2680
Query: 3144 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3203
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2681 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2740
Query: 3204 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3259
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2741 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2800
Query: 3260 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3319
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2801 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2860
Query: 3320 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3378
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2861 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2920
Query: 3379 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3438
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2921 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2980
Query: 3439 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3492
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2981 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 3040
Query: 3493 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ--YSVLEGDAHTHETTLRDLQ-ELQVHC 3549
K ++ + +Y+ ++ W+ + Q L++ + + + L+ LQ E+ H
Sbjct: 3041 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 3100
Query: 3550 AEGQALLN------SVLHTREDVIPS---GIPQAEDRA----------LESLRQDWQAYQ 3590
+ L N SV ++V+ + Q D LE++ Q ++ +Q
Sbjct: 3101 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 3160
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQV--DEWLKTAEEKKWHEEVTAYRDEVEEVGARAQ 3648
E++ Q +L + + Q +++L + ++ + + A + +V+ AQ
Sbjct: 3161 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ--KSLQALKHQVDLAKRLAQ 3218
Query: 3649 EILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3705
+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3219 DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3278
Query: 3706 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3765
+ ++A +T+ K+ +T++ LK +E L ++ + + K +
Sbjct: 3279 FAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKTCKMMLA 3332
Query: 3766 GEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEY 3820
E +++++ +Q +L + +E + +EF K K + + +
Sbjct: 3333 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3392
Query: 3821 QEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK 3880
+E ME QL+ +K Q K++
Sbjct: 3393 EEHEESQGPVGMETETINQQLNMFKVFQ-----------------------------KEE 3423
Query: 3881 IDQLQSDYQDLCSIGKAMMEEIA------GFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 3934
I+ LQ QD+ +G+ +++ A G E L+++ + TL +
Sbjct: 3424 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK------------ 3471
Query: 3935 VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSR-QDTLQQCQAWLSAVQPDLEPSPQ 3993
AQR Q E L H R QD L+ +W+ + +L + +
Sbjct: 3472 -----------------VAQRAAQLQEALL--HCGRFQDALESLLSWMVDTE-ELVANQK 3511
Query: 3994 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK--- 4050
PP + + +K +QEQ LL + D ++V+ ++ ++ T E
Sbjct: 3512 PPSAEFKVVKA-----QIQEQK-----LLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561
Query: 4051 --LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM----KRRHSELELNIAQNMVSQV 4104
L Q L WE + + K+E ++QL+ + ++ H LE +
Sbjct: 3562 KILKQLSLLDSRWEALLN-KAET------RNRQLEGISVVAQQFHETLE---------PL 3605
Query: 4105 KDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4164
+++ ++ + + I + +KL +E+ +HK + ++
Sbjct: 3606 NEWLTTIEKRLVNCEPIGTQASKL--EEQIAQHKALE--------------------DDI 3643
Query: 4165 LQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ + H +++ + + E ++ +S + + V + +QE+ ++ +L
Sbjct: 3644 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY-------IEIQEKSHSRSEL 3696
Query: 4225 KDQKQKMIEHLNLDDKEL------VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVV 4278
Q + D+ EL V ++ S L + + E L K++ ++ V + L
Sbjct: 3697 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3756
Query: 4279 QSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDAD 4338
Q+ Q L+ N E LKQ+ ++ L I +LEA +K+ KD
Sbjct: 3757 QNVDQALL--------NGLELLKQTTGDEV--------LIIQDKLEA----IKARYKDIT 3796
Query: 4339 RVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQI 4398
++ D+ Q +Q A +H +L K + LS +TQ L + SQ
Sbjct: 3797 KLSTDVAKTLEQALQLARRLHSTH----EELCTWLDKVEVELLSYETQVLKG--EEASQA 3850
Query: 4399 QQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL--WAQGRELMKEVTEQ 4456
Q P ++ K+ K K+ SL + + L W L K V E
Sbjct: 3851 QMR-------------PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED 3897
Query: 4457 EKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD--IVT 4514
+ + V D++ QK ++E++ ++ + F + D W+ + + +++
Sbjct: 3898 N--------ERYRLVSDTITQK----VEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3945
Query: 4515 FPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKL 4574
+I L E + QL + + +++++ L ++G I+ + +E + + +KL
Sbjct: 3946 LGDIRL--EQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 4003
Query: 4575 NALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLA 4634
+ + + ++ I + +++ +++ A ++ E L+E ++ +S++P
Sbjct: 4004 DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI---ISQLPAPAL 4060
Query: 4635 VEEAL-SLQDGCRAILDEVAGLGEAVDELNQKKEGFR--STGQPWQ-PDKMLHLVTLYHR 4690
E L Q+ R + + +A +D++N+ S G+ + +K + TLY +
Sbjct: 4061 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 4120
Query: 4691 LKRQTEQRVSLLEDTTS-AYQEHEKMCQ---QLERQLKSVKEEQSKVNEETLPAEEKLKM 4746
+K ++R L++ S + Q H+K+ Q LER ++ +++ S ++ E +E++
Sbjct: 4121 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPS-ISAEVEKIKEQISE 4179
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+++ ++ + + + E++ + + +Q ++ + I V
Sbjct: 4180 NKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVE 4239
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQI-------- 4858
E E++++ ++ + W + L + ++D Q+ IR ++
Sbjct: 4240 EREAKLLDVMELAEKF-----WCDHMS--------LIVTIKDTQDFIRDLEDPGIDPSVV 4286
Query: 4859 --HQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELSELDGDIQEA 4909
QE ++ ++ L + ELI+A ++ S+ EL+ + +A
Sbjct: 4287 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4346
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEENLKSHMEFF 4968
+ R L E +Y QA DW++ A +L ++ G D+E+ ++ ++ +F
Sbjct: 4347 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4406
Query: 4969 STEDQFHSNLEEL-HSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027
S Q +E L H L + + + K ++ + L+L + + L+
Sbjct: 4407 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4466
Query: 5028 CTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 5087
+Q A +E++ + TE LSE + E +L++H L + V +
Sbjct: 4467 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVG-GDPKAIEIELAKHHVLQNDVLAHQST 4525
Query: 5088 IVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNN 5147
+ A+ + + L ++ + L + + QRW + + +++ L+ A+ + GF+
Sbjct: 4526 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4585
Query: 5148 KVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSM 5207
+++ + + + L S L H E ++ L Q+ M
Sbjct: 4586 EIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4645
Query: 5208 LQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCW 5267
L A E + Q+I ++++ +++ K+ +++ L + W
Sbjct: 4646 L---ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4702
Query: 5268 VQETKEYLG---NPTIEIDA---QLEELQILLTEATNHRQNIEKMAE--------EQKEK 5313
+ + ++ L P++ +D Q++E ++ E +HR+ I ++ + QK+
Sbjct: 4703 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4762
Query: 5314 YLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
+ + +L S S V ++ + D K +Q +L +++ K L +
Sbjct: 4763 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4822
Query: 5374 LTKL----KAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK 5429
L K KT + Q K QK LG + + + + L++ L K
Sbjct: 4823 LEIANDPDKIKTQ-LAQHKEFQKSLGAK-----HSVYDTTNRTGRSLKEKTSLADDNLKL 4876
Query: 5430 IGKLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN 5486
L+EL + ++ R +KL +A ++ + L+ ++ W+ + +
Sbjct: 4877 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE---------- 4926
Query: 5487 SASQLREQYILH------QTLLEESKEIDSELEAMTEKLQYLT---------SVYCTEKM 5531
QL E +H L++ K EL T +Q L S + +
Sbjct: 4927 --PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4984
Query: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV-- 5589
Q+ EL E + + + L+ A + ++F + + L L +A+ TL V
Sbjct: 4985 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 5044
Query: 5590 -GRLSLKEQLSHRQHLLSEMESLKPKV-QAVQLCQSALRI--PEDVVASLPLCHAALRLQ 5645
+L+ + + + ++E + ++ +A + + L I P+ + + H ++
Sbjct: 5045 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITT---IKHWITIIR 5101
Query: 5646 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI--EDKPVATSNIQEL 5703
+ A Q + +A+ ++ ++ L ++ A + +DK V I+E+
Sbjct: 5102 ARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 5161
Query: 5704 QAQISRHEELAQKIKGYQEQIASLNSKCK 5732
+A I+ H+ +++ Q + + K
Sbjct: 5162 KALIAEHQTFMEEMTRKQPDVDKVTKTYK 5190
Score = 270 bits (691), Expect = 4e-71
Identities = 774/4191 (18%), Positives = 1624/4191 (38%), Gaps = 555/4191 (13%)
Query: 4702 LEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVL 4761
L S + H+ + + +E S+KE +K++E + A KL Y L+ L
Sbjct: 809 LPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLT-YAEKLHRLESQYAKL 865
Query: 4762 KRVTIHLEDLAPHLDPLA--YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
+ + E HLD L +A +++ W E + + +E + + + D+
Sbjct: 866 LNTSRNQER---HLDTLHNFVSRATNEL-IWLNEKE--EEEVAYDWSERNTNIARKKDYH 919
Query: 4820 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4879
E+ R LD N++ +QE ++ + + ++ A +
Sbjct: 920 AELMRELDQKEE-------------NIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWS 966
Query: 4880 KFTKAKELISADLEHSLAELSELDGDIQEA---LRTRQATLTEIYSQCQR---YYQVFQA 4933
+ + + ++ + A E D +EA LR + + YS C R +++
Sbjct: 967 WILQLCQCVEQHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYS-CDRSSSIHKLEDL 1024
Query: 4934 ANDWLEDAQELLQ-------LAGNG-----LDVESAEENLKSHMEFFSTED--QFHSNLE 4979
+ +E+ +ELLQ L G L +++ LK+ + + D Q +
Sbjct: 1025 VQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIY 1084
Query: 4980 ELHSLVATLDP------LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL-LQRCTAQW 5032
+ V + +I PTG E + V + + D +++ Q W
Sbjct: 1085 KDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW 1144
Query: 5033 HDYQKAREEVIE---LMNDTEK-KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI 5088
H+ + V+ L+N+ ++ + S + +KT EH+ ++S + S E
Sbjct: 1145 HESHINMKSVVSWHYLINEIDRIRASNVASIKTMLP-------GEHQQVLSNLQSRFEDF 1197
Query: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
LE+ +G+D ++ L + + Q + L A+ +E+ E++V + + ++
Sbjct: 1198 --LEDSQESQVFSGSDITQ--LEKEVNVCKQYYQELLKSAEREEQ--EESV--YNLYISE 1249
Query: 5149 VKKATEMIDQLQDKLPG---SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTL 5205
V+ ++ +D+L + E+ E + + + ELE+ + LG + +
Sbjct: 1250 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1309
Query: 5206 SMLQDGAAPTPGEEPPLMQEITAM---QDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262
AA + P L E+ + ++ +M K V LK+ + E +
Sbjct: 1310 EFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1367
Query: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTIL 5321
+ + E + + + I+ + L+ +E RQ + +E QK K +
Sbjct: 1368 LYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS----- 1421
Query: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
E+ E LD + D++ E Q + QI +DL I LK
Sbjct: 1422 -DEMFKTYKERDLDFDWHKEKADQLVE------RWQNVHVQIDNRLRDLEGIGKSLKYYR 1474
Query: 5382 DN-------VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLT 5434
D + Q +T Q+ + E NSK + QK L ++ + + K
Sbjct: 1475 DTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1533
Query: 5435 ELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW-IEKAKVLAHGTIAWNSASQLRE 5493
E + T++ E + Y M++ K +++ ++ + + LR
Sbjct: 1534 EQYSATVKDYELQTMT----------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1583
Query: 5494 QYILHQTLL---------------EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538
+Y TL+ EE K ++ E + EK + L + + AE
Sbjct: 1584 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1643
Query: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598
+ +Q I + ++ + ++ L+ +Q L + +T E L + +
Sbjct: 1644 AGKPPFSKQKI-----SSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1698
Query: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP---------LCHAALRLQEEAS 5649
+ L ESLK ++Q Q +++ E +VA +C L Q E
Sbjct: 1699 LQESYNLLFSESLK-QLQESQT-SGDVKVEEKIVAERQQEYKEKLQGICD--LLTQTENR 1754
Query: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 5709
+ H Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + + T N +
Sbjct: 1755 LIGH---QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLK-----EN 1806
Query: 5710 HEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
E+L+Q+ K EQ + KC+ L +KA+ + L + E TE +
Sbjct: 1807 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1866
Query: 5769 SAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGTN-SEISSPPACRS------ 5810
S S V + R T V E++G +EG S I
Sbjct: 1867 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1926
Query: 5811 -PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 5867
V T ++NQ YQ + A E++ + + +T ++Q E + + +
Sbjct: 1927 VDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKE 1983
Query: 5868 DLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5926
LQ++ + LK YE AL +K S+ ++E + +E + E
Sbjct: 1984 KLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE 2035
Query: 5927 SQMAEHQALMDEILMLQDEINELQSSLAEELVS-------------------ESCEADPA 5967
++ +A D+I L ++ Q S +E+++S +SC
Sbjct: 2036 QELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 2094
Query: 5968 EQLALQSTLTVLAERM--STIRMKAS-GKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL 6024
++ +T + ++ +T R ++ K +L L D +++ Q Y + L
Sbjct: 2095 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY------QHYEDASCGL 2148
Query: 6025 DSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
+ L + +AT LS P +P +++ QL + + + +I + VA+ +L E +LL+
Sbjct: 2149 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAE-VLLD 2207
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 6142
+ + L + G +L ++++++ +Q +T T+S VQ
Sbjct: 2208 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------------ITLTRSLSVQ 2255
Query: 6143 EWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSVASRGEEILIQHSAAE 6195
+ L + W +SSL++Q + L+ +++ L + +A R I + +
Sbjct: 2256 DGLDEM-LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2314
Query: 6196 TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH--QEFSTKQKLLQNVLEQEQEQV 6253
+ + S + M+ + + E+L +E TK +L +N+ E+ Q
Sbjct: 2315 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL--SEKLQT 2372
Query: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY 6313
+ L+ V DVP +D + L+Q +E +S+ K+ L L
Sbjct: 2373 FLETKTQALTEV-----DVPGKDVTE-------LSQYMQESTSEFLEHKKHLEVLHSLLK 2420
Query: 6314 DGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAF 6373
+ +++ LP + L L+K KEM + + + K +
Sbjct: 2421 E-----------------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC- 2462
Query: 6374 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQILNFQN--DLKVLFTSL 6429
E D V+ +L + + +V + + L+ Q LK
Sbjct: 2463 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2522
Query: 6430 ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------ 6483
+N I L L + P A+ I A++ +G L G E+
Sbjct: 2523 VNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNGEGTATNTEEFWANKG 2571
Query: 6484 --PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540
++++ + Y++L +++ + + LN L+ L+ E + + L + +
Sbjct: 2572 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2631
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET--------QFH 6592
Q + E ++ ++++K + L+ ++ + L K+ + Q
Sbjct: 2632 QQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQML 2691
Query: 6593 TELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 6652
TE+ ++ + + R +LE + + +L + L E + +G + + +
Sbjct: 2692 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2751
Query: 6653 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD------LESQLNQLGECWL 6706
L + Q L +P+ Q+ G+ +L S D ++ QL + + W
Sbjct: 2752 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLRGIVKEQLAAVTQKWD 2810
Query: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
S T ++S ++ + T+YQS L L ++L S+ V + +
Sbjct: 2811 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS----SSLAVSTHPDAMNQ 2866
Query: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 6826
L + +E+ + + L L K + L++ELSR Q +L +
Sbjct: 2867 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSR---QLEGILKSFKD 2921
Query: 6827 VQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDEDNIKNSIGYK--AIHE 6877
V++K Q S H ++ +W+ +K+E N + I K +
Sbjct: 2922 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT-----KKEEQNKSHPISAKLDVLES 2976
Query: 6878 YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG 6937
++ +K F + + +++ + + ++++ S+K QL + +W
Sbjct: 2977 LIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 3033
Query: 6938 LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997
V E+ L+ LE +Y+ V+ L W + + L++ D A +N++ + L+
Sbjct: 3034 QVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQ 3093
Query: 6998 ------------------DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST---LREL 7036
L+ E + E + +LIQ K + V+ + S L +
Sbjct: 3094 KEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCLENM 3152
Query: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096
Q + + + K L+ +Q H D + S +Y L+ + SL+A++
Sbjct: 3153 TQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY-LTMLQTQQKSLQALK 3207
Query: 7097 VQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
QVD + L DL + E Q+ +++ Q+ ++C L L
Sbjct: 3208 HQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC-----SFLETKL 3262
Query: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
+ + N + E ++ + L + +D A T+Q+Q++ LK
Sbjct: 3263 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQKETIKAFLKKLEALM 3317
Query: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
++D + C +L T D + I+ D +LS+
Sbjct: 3318 ASNDNAN---KTCKMMLATEETSPDLV--------------------GIKRDLEALSKQC 3354
Query: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322
L ++ ++ + E F L+ + +AEE + Q P + TI +++
Sbjct: 3355 NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV-GMETETINQQL 3413
Query: 7323 EELKG-QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL-------NRHWSLISSQTT 7374
K Q + + +N LG L + + Q L N W ++ +
Sbjct: 3414 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3473
Query: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRAHELFQAE 7432
+R ++LQ LL F + E+ + ++V TE+ +A + S ++ + Q + +L Q
Sbjct: 3474 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3533
Query: 7433 MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7492
+ R+ + I +G+++ + D+ + +L+LL ++W+ ++ +A+ R ++
Sbjct: 3534 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3593
Query: 7493 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVFLRQQGSY 7550
Q++ E E L +WL + ++ PI Q ++ Q K E +
Sbjct: 3594 VAQQFHETLEPLNEWLTTIEKRLVN---CEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3650
Query: 7551 ILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASMRLEEQKKKLAFLLKD 7603
V G+ L + + + +Q++L EIQEK S S L++ +D
Sbjct: 3651 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3710
Query: 7604 WEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQ----MRCKELENAVGSWTDDL 7657
+ + + +KL + ++ L EL Q +R + ++ A+ L
Sbjct: 3711 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQAL------L 3764
Query: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
L LLK T + D++ I+ +++E ++ +++++ + + + + L
Sbjct: 3765 NGLELLKQT-----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3819
Query: 7718 NKELCEWLTQMESKV-SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKAS 7776
++ELC WL ++E ++ S +L E + + +E A+ NK L + E ++ A
Sbjct: 3820 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNE-VSSAL 3878
Query: 7777 HES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 7832
E +A E +E + + N+R++ + D I +V+++ ++ QQ D+ + +W+
Sbjct: 3879 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3938
Query: 7833 IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7892
E +L + ++ +L Q+ +I +H + ++ ++ C ++
Sbjct: 3939 TEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC----SE 3993
Query: 7893 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 7952
E S+++ + + + IC ++ ER L++E L +F + Y WL ++ +
Sbjct: 3994 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 4053
Query: 7953 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 8012
+ + Y +++ ++ + + E ++ +NK +L E S+++
Sbjct: 4054 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGEGFSIQEKYV 4112
Query: 8013 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8072
+ + +++ V L I Q +F D IL L + +L S +V+
Sbjct: 4113 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS-AEVE 4171
Query: 8073 AKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIEEELDELRRY 8124
KIK+ + + +S++ K+ E + +GE++I +S + + A ++++LD++
Sbjct: 4172 -KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFI 4230
Query: 8125 CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 8184
+ + VE +RE +L D L++ W D + +++ + +
Sbjct: 4231 WENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS-LIVTIKDTQ 4270
Query: 8185 NLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
+ L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4271 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC--------- 4321
Query: 8238 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 8297
G+ DK + I E A+ L + A+++ + Q L
Sbjct: 4322 -GEPDKPIVKKS--------IDELNSAWDSLNKAWKDRIDKLEEAMQAAV-QYQDGLQAV 4371
Query: 8298 RFQIQQTENIIRSKTPTGPELDTSYKGYMKLL---GECSSSIDSVKRLEHKLKEEEESLP 8354
+ + S +P G +L+T + +L E ++RL H+ + + +
Sbjct: 4372 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4431
Query: 8355 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8414
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4432 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4491
Query: 8415 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 8473
L + + + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4492 LSEQK--PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4549
Query: 8474 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 8533
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4550 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4609
Query: 8534 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 8578
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4610 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4662
Query: 8579 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8629
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4663 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4707
Score = 270 bits (691), Expect = 4e-71
Identities = 734/4041 (18%), Positives = 1546/4041 (38%), Gaps = 628/4041 (15%)
Query: 449 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1290 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1347
Query: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
K++ + L +L AE+ +K + K E+V N + I K +
Sbjct: 1348 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE----- 1399
Query: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
+ + +++ + +++A+ + M +T + R+L + ++ ++++ W N
Sbjct: 1400 -VDEKRQVFHALEDELQKAKAISDEMFKTYKE-RDLDFDWHKEKA--DQLVERWQ---NV 1452
Query: 629 VASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ 688
+ L D E + +S +D + L WIQQ + ++ L Q
Sbjct: 1453 HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ 1511
Query: 689 QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT----DCVVTLSAFATEAHKKLSEPLEV 744
Q +L++ +E+KQ ++ DE + ++Y+ D + + + P++
Sbjct: 1512 QKMLVSE------IEMKQ-SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR 1564
Query: 745 SFM--NVKLLIQDLEDIEQR----VPVMDAQYKIITKTAHLITKE--SPQEEGKEMFATM 796
M + L+IQ+ D+ R V +M K + + +E S +EE KE
Sbjct: 1565 RRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA 1624
Query: 797 SKLKEQLTKV-----------KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEII 845
+L++ ++ + K +S S+++ E+L + + + L K + +
Sbjct: 1625 KELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKM 1684
Query: 846 TVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ---- 901
T ER + + L E+ K+ G V++ + ++ ++
Sbjct: 1685 TDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGI 1744
Query: 902 ----TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
T+ + ++ AF + T + KK+ L K + S L +V++ + L
Sbjct: 1745 CDLLTQTENRLIGHQEAFM-IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1803
Query: 958 EEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD 1017
+E G+ + E + ++Q++ A +K C++L ++ EQ ++ L + V
Sbjct: 1804 KENGE-----KLSQEDKALIEQKLNEAKIK-CEQL-NLKAEQSKKELDKVVTTA------ 1850
Query: 1018 LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP--QEGSEKIIKEHRVFFSDK 1075
+K + EK + +EE +T+++ + + SE+ +H+
Sbjct: 1851 -----------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1899
Query: 1076 GPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD 1135
G H I E D V ++ ++ + +T L + K K
Sbjct: 1900 GTHFQEGDGKSAIGE-------EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVK- 1946
Query: 1136 YTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRL 1195
++ IS ++ + + + G+ E+ E L L
Sbjct: 1947 -----AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEK---------EKLQKNMKEL 1992
Query: 1196 KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
KV E + LA+ K +L E+EK +++ + + + + LE L
Sbjct: 1993 KVHYETA-----------LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 2041
Query: 1256 ISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD 1315
+G+ ++ K+ ++ E ++ H+ + I+ V + + +GG D
Sbjct: 2042 EAGADDINGLMTKLKRQKSFSED---VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 2098
Query: 1316 RG--HEEL-RKLESTLDGLERSRERQE---RRIQVTLRKWERFETNKETVVRYLFQTGSS 1369
H E+ RKL+ D + ++ + K++ +E ++ L ++
Sbjct: 2099 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2158
Query: 1370 HERFLS---FSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL---- 1422
+ LS ++L +LE+TK + S V E L K+ +E+ L + L
Sbjct: 2159 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL-KKTAEVLLDARGSLLPAKN 2217
Query: 1423 ------------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470
+ +KS+ E+ +KL+ TL + + + D G+ +
Sbjct: 2218 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN--------VE 2269
Query: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530
KE + +S+A+ IS+ + Q+I + SSI + E+ + F + ++ ++
Sbjct: 2270 SSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQ 2329
Query: 1531 AKLTQI-RRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI- 1588
AK+ + R+ E +H + L + L + + ENL + Q+ E + + + +
Sbjct: 2330 AKMKDLSARFSEASHKHKETL--AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2387
Query: 1589 CSSATETYKVLQ-------EHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ 1641
TE + +Q EH + L SL I++ + K + + + +
Sbjct: 2388 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNNLSKKFK 2446
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA------- 1694
+ ED ++ KE T+ + L +Q L K L S W++ K + A
Sbjct: 2447 EMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAEDLGKSL 2503
Query: 1695 -DRVKVEGELQL----IQALQNEVVSQASFYSKLLQLKESLFSVAS-------------- 1735
D K++ + L IQ + N +S + S + +++ +V S
Sbjct: 2504 EDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNT 2563
Query: 1736 -----KDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
+ +K + + + DL ++ +I L + +++ Q+ E + W+
Sbjct: 2564 EEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQK 2623
Query: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED- 1845
K QT + + + ++K AE++ ++Q L+ L +L L D
Sbjct: 2624 MNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL--LEENPDT 2681
Query: 1846 ---------LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGIL--RQL 1894
L + K ++ QL + Q +E + ++L +F A L L ++L
Sbjct: 2682 PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEE---SSNNLTQFQTVEAQLKQWLVEKEL 2738
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQ----NAKALESAAVSLDGILSKAQYHLKIGSSE 1950
+V S++ N + + + LQ E + GILS+ E
Sbjct: 2739 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--------PGE 2790
Query: 1951 QRTSCRATADQLCGEVERIQNLLGTKQSEADAL--AVLKKA-FQDQKEELLKSIEDIEER 2007
+ +QL ++ +L G D + A++K +Q L + D++ +
Sbjct: 2791 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2850
Query: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ--KDVAFAPEVDR 2065
A+ Q+L +++ E+ + ++ + + ++ K+ E+ R
Sbjct: 2851 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2910
Query: 2066 EINRLEVTWDDTKRL----IHENQGQCC-------------GLIDLMREYQNLKSAVSKV 2108
++ + ++ D ++ + Q C +D +E QN +S
Sbjct: 2911 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2970
Query: 2109 LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS 2168
L+ V + IKD +D FSK TA++ M K ++G++L L K
Sbjct: 2971 LD------VLESLIKDHKD----FSKTLTAQSHMYEKT------IAEGENL---LLKTQG 3011
Query: 2169 SDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL-----------SIW----------D 2207
S+ + ++ + + W +++++E ++L+ SL ++W +
Sbjct: 3012 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 3071
Query: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK----------EFESEV---KNK 2254
++ D EG N + ++ +D H ELL E + EV +NK
Sbjct: 3072 EIKFCLDPAEG--ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 3129
Query: 2255 AL------RLEELHSKVNDLKELTKNL--------ETPPDLQFIEADL------------ 2288
+L E+LHSK L+ +T+ E+ LQ + L
Sbjct: 3130 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3189
Query: 2289 ----------MQKLEHAKEITEVAKGTLKDFTAQST----------QVEKFINDITTWFT 2328
+ L+ K ++AK +D +++ QVE + +T
Sbjct: 3190 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3249
Query: 2329 KVEESL---------MNCAQNETCEALKKVKDIQKE-------------LQSQQSNIS-- 2364
+V+E + QN E + + E LQ Q+ I
Sbjct: 3250 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF 3309
Query: 2365 --------STQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK 2416
++ +N N C+ + E S + G+ + EA+S+ C+K Q + E+
Sbjct: 3310 LKKLEALMASNDNANKTCKMMLATEETS--PDLVGIKRDLEALSKQCNKLLDRAQ-AREE 3366
Query: 2417 HFSESMQEFQEWFLGAK------AAAKESSDRTGDSKVLEAKLHDLQNIL-----DSVSD 2465
+++ +E++ K A+E + G + ++ N+ + +
Sbjct: 3367 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3426
Query: 2466 GQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQALQDCASEL 2524
Q K V GQ L +K ++ + N ++ K+ + LQ+
Sbjct: 3427 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3486
Query: 2525 GSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES-LDK 2583
G F+D L W+ + EE + ++ + + + + K+ L LL R+S ++
Sbjct: 3487 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL---LQRLLDDRKSTVEV 3543
Query: 2584 LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ------VALQEHEALE 2637
+ + G+ ++ A + L L + + K + R+ Q VA Q HE LE
Sbjct: 3544 IKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3603
Query: 2638 EALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ---IQDILLMKGEGEVKLNMAIGK 2694
+ W+ I+ RL E LE++++Q ++D ++ + L+ A+
Sbjct: 3604 PLNE----WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK---HLHQAVSI 3656
Query: 2695 GEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2754
G+ S++E + ++Q++L+ + + +I S L+ + + E + +L
Sbjct: 3657 GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3716
Query: 2755 WMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK---T 2811
W+ V K+ K + D+ L + + R L I ++ ++
Sbjct: 3717 WLNEVHDKL-----------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3765
Query: 2812 EDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELH 2871
E K T +E+ D + K + + + ++ D L+ + LHS EEL
Sbjct: 3766 GLELLKQTTGDEVLI-IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3824
Query: 2872 RWSD-------------MSGDSSA--------TQKKLSKIKELIDS-REIGASRLSRVES 2909
W D + G+ ++ +K+ K L+DS E+ ++ L V
Sbjct: 3825 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3884
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA-LSEQE---F 2965
A E + A E + ++ + ++ ++Q + ++++ ++E E
Sbjct: 3885 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3944
Query: 2966 SGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR 3022
S +LEQ +Q SA L KT+ + +L K+ +++V+ HK I+ A +E
Sbjct: 3945 SLGDIRLEQ--DQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHK---IMTAC--SEEE 3995
Query: 3023 TEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLC-LQASKGCQ-NKEQILQQRFRKAF 3080
+ +K +L++ ++K Y+ +C + + + Q + Q L +F + +
Sbjct: 3996 KQSMKKKLDK-----------------VLKNYDTICQINSERYLQLERAQSLVNQFWETY 4038
Query: 3081 RDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF--LSE--SENGQHKLNMMLSKGE 3136
+ WL T + +P E T Q+ +E L E +E+ H M + +
Sbjct: 4039 EELWPWLTE---TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 4095
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
LL L+ + IQ K AA + ++ ++ AL+ Q F + I + L
Sbjct: 4096 LLE--LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4153
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL------WEG 3250
+ + + + + ++ + + + ++V ++ +P LK++ +++ +
Sbjct: 4154 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4213
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKEKVSRL-------DRIVAEHNQFSLGIKELQDWM 3303
++K+ + ++ Q+ + + L +E+ ++L ++ +H + IK+ QD++
Sbjct: 4214 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4273
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
D P D SV+ + E + + ++ +++ G ++
Sbjct: 4274 RDLE-------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDK 4326
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
P +++ + + W SL A +LE A+ YQDG++ W+D L
Sbjct: 4327 PIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS 4386
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIE-------VKGAGMTEHYVTQLELQDL 3476
+L + + K E +E + K ++ + Q L +L
Sbjct: 4387 PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMEL 4446
Query: 3477 QERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHE 3536
+ + +++ER K E + ++Q L WL + L + + GD E
Sbjct: 4447 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4506
Query: 3537 TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALESLRQDWQAYQHRL 3593
L LQ Q+ + +V D+I S + LE L Q WQ +
Sbjct: 4507 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4566
Query: 3594 SETRTQFNNVVNKLRLMEQKFQQVDEWL-----------------KTAEEK-KWHEEVTA 3635
+ + Q + + + + + + + +WL +TA+E+ H EV A
Sbjct: 4567 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4626
Query: 3636 YRDEVEE----VGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3689
+ EE + + Q++L + + L +++++ ++ E+ LEE +
Sbjct: 4627 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4686
Query: 3690 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV-DTVMMGKKLKTLEVLLKDMEKGHSL 3748
E +SL + +W + NVA++ + DTV+ ++ +V ++
Sbjct: 4687 NLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF--QIDEHKVFANEVNSHREQ 4743
Query: 3749 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3808
+ + G + ++ + ++ + + +++ + + +L+ AK+F +
Sbjct: 4744 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4803
Query: 3809 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3868
L +W+ E ++ L E + + K QL+++K Q+++ + + G +L
Sbjct: 4804 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863
Query: 3869 LELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3928
E +L D D L+ D D L+ L+ K DT+ G+ + Q
Sbjct: 4864 KE---KTSLAD--DNLKLD-------------------DMLSELRDKWDTICGKSVER-Q 4898
Query: 3929 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 3988
KL++ + Q T D+ A+ R+ L + H D + A Q +L
Sbjct: 4899 NKLEEALLFSGQFT-DALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKEL 4956
Query: 3989 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLD--------LLCSMCDLSNASVKTTAKDI 4040
K+ +AL+ AR ++ + M +LS A I
Sbjct: 4957 G-------------KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 5003
Query: 4041 QQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL--ELNIAQ 4098
+ + +E L QA EE + L +L +A+Q L R H L + + +
Sbjct: 5004 SK-QTRLEAALRQA-------EEFHSVVHALLEWLAEAEQTL----RFHGVLPDDEDALR 5051
Query: 4099 NMVSQVKDFVKKLQSKQASVN 4119
++ Q K+F+KKL+ K+A +N
Sbjct: 5052 TLIDQHKEFMKKLEEKRAELN 5072
Score = 264 bits (674), Expect = 3e-69
Identities = 856/4706 (18%), Positives = 1829/4706 (38%), Gaps = 694/4706 (14%)
Query: 2615 LLRMTKEKLRSCQVA--LQEHEALEEALQSMWFWVKAIQ---DR------LACAESTLGS 2663
L+++ K L+S + L E E + +Q + WV +Q DR L ES L +
Sbjct: 759 LMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN 818
Query: 2664 KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723
+ + + + + L E+++ + + +L L+ +A
Sbjct: 819 HKNVHRAIEEFESSLKEAKISEIQMTAPL--------------KLTYAEKLHRLESQYAK 864
Query: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWM-ESVDQKIEHPLQPQ-PGLKEKFVLLD 2781
++++S + + L+++ +++V R W+ E ++++ + + + K
Sbjct: 865 LLNTSRNQERHLDTL----HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 920
Query: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841
L L + E++ +++ + + L E + + ++TQ++ I+ + +
Sbjct: 921 ELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQTQWSWILQLCQ----C 974
Query: 2842 VEEIVKDHLMYLDAVH---EFTDWLHSAKEELHRWSDMSGDSSA------TQKKLSKIKE 2892
VE+ +K++ Y + + E TD+L + K+ + R SS Q+ + + +E
Sbjct: 975 VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 1034
Query: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC-L 2951
L+ + A+ + + +++ +N S C L + D++Q E ++++ C L
Sbjct: 1035 LLQYKSTIANLMGKAKTIIQLKPRN---SDCPLKTSIPIKAICDYRQIEITIYKDDECVL 1091
Query: 2952 ENLVSQMALSEQEFSGQVAQL-----------EQALEQFSALLKTWAQQLTLLEGKNTDE 3000
N + +G A + ++A++ + + + + LTL + +
Sbjct: 1092 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 1151
Query: 3001 EIVECWHKGQEILDALQKAEPRT-------------EDLKSQLNELCRFSRDLSTYSGK- 3046
+ V WH +D ++ + + +L+S+ + S++ +SG
Sbjct: 1152 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1211
Query: 3047 VSGLIKEYNCLCLQ------ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDI 3100
++ L KE N +C Q S + +E+ + + R+ + L N + +
Sbjct: 1212 ITQLEKEVN-VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1270
Query: 3101 PQNISEVSTSLQKIQE---FLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTA 3156
P ++ S+ +I E E E + L + +K E S +++++
Sbjct: 1271 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1330
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT--EKMVHESSNRLYDLP 3214
++ +S L+ + + +K+ + + ++ + +K E+ V N + +L
Sbjct: 1331 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1390
Query: 3215 AKRRE-QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN 3273
+ ++ + ++ + H E +L + K + +++ K+++ R
Sbjct: 1391 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF------KTYKERDLDFDWH------ 1438
Query: 3274 LTKEKVSRL-DRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3332
KEK +L +R H Q +++L+ + D+Y HP D
Sbjct: 1439 --KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY-HPLDDW------------ 1483
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3392
++Q + Q K +Q PE T+ QL K +L + I K
Sbjct: 1484 ---IQQVETTQRK---------IQENQPENSKTLATQLNQQK-----MLVSEIEMKQSKM 1526
Query: 3393 GALSKWTS-YQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS--- 3448
K+ Y V+ + + A ++ ++ + R M A L+ +E +
Sbjct: 1527 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR---RMQSSADLIIQEFMDLRT 1583
Query: 3449 -YSSL--LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505
Y++L L T +K AG + L+ L+E ++++E KE V K+++L +
Sbjct: 1584 RYTALVTLMTQYIKFAGDS--------LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1635
Query: 3506 RDLKAFEV---------------------WLGQEQEKLDQYSVLEGDAHTHETTLRDLQE 3544
+ LK E L + + + + GD T E ++
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1695
Query: 3545 LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN-- 3602
++ L + L ++ SG + E++ + +Q+++ + + TQ N
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1755
Query: 3603 -------VVNKLRLMEQKFQQVDEWLKT---------AEEKKWHEEVTAYRDEVEEVGAR 3646
++ + +K+Q E L+ AE K E ++ E++
Sbjct: 1756 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL--KENGEKLSQE 1813
Query: 3647 AQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE-----IQSLEESESSLSS 3701
+ ++++ +++ C+ L + L + EE ++ LEES++ + +
Sbjct: 1814 DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIEN 1873
Query: 3702 YSDWYGSTHKNFKNVATKIDKV----------------------------DTVMMGKKLK 3733
DW + K+ + TK +V +T + G+
Sbjct: 1874 LLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGT 1933
Query: 3734 TLEVLLKDMEKGHS--------------LLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
T E L + +K + +SA+ E+ +YL E E+L+K +M
Sbjct: 1934 TQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----NM 1989
Query: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
++LK T E EK + L ++ L ++ A+Y E H ++ + EL +A
Sbjct: 1990 KELKVHYETALAES---EKKMKLTHSLQEE---LEKFDADYTEFEHWLQQSEQELENLEA 2043
Query: 3840 ----------QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQ 3889
+L + KS + V+SH+ ++ + G +LE + + +D
Sbjct: 2044 GADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD------GGKV 2097
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
D + + + ++ DR +L K + L D + + H + A
Sbjct: 2098 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK------YQHYE------DAS 2145
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4009
C + Q+ E KH+S + +Q LE + + + Q
Sbjct: 2146 CGLLAGL-QACEATASKHLSEPIAVDP-----KNLQRQLE---ETKALQGQISSQQVAVE 2196
Query: 4010 ALQEQARTYLDLLCSMCDLSNASVKTT----------AKDIQQTEQTIEQKLVQAQNLTQ 4059
L++ A LD S+ N KT +K + + + ++ L ++ ++
Sbjct: 2197 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2256
Query: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119
G +E+ + L++ Q L Q+++S+ + + +Q+S+N
Sbjct: 2257 GLDEMLDWMGNVESSLKEQGQV---------PLNSTALQDIISKNIMLEQDIAGRQSSIN 2307
Query: 4120 TIIEKVNKLTKKEE----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
+ EKV K + + S ++ L+ ++ + + + EE + + +
Sbjct: 2308 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2367
Query: 4176 NVVEVFLEKFT---TEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232
++ FLE T TE D + E + E+ + E K +E L +++
Sbjct: 2368 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL----EHKKHLEVLHSLLKEIS 2423
Query: 4233 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4292
H DK LV E+T++L +++ ++ED IK K + + E+L+ Q + L W +E
Sbjct: 2424 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2483
Query: 4293 -------QPNI-AEAL------------KQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
QP+ AE L K S Q + +++C+ + A K+
Sbjct: 2484 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2543
Query: 4333 L--IKDADRVM-------------ADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4377
+ +K V+ A+ GL I+K ++D L L+ + L
Sbjct: 2544 IAAVKSGGAVLNGEGTATNTEEFWANKGLTS---IKKDMTDISHGYEDLGLLLKDKIAEL 2600
Query: 4378 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD---VSKQVKTCKSAQASLKT 4434
N LS K Q A Q Q K + P D V QV+ KS +A LK
Sbjct: 2601 NTKLS-KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2659
Query: 4435 YQNEVTGLWAQGRELMKEVTE-QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493
N+V L + EL++E + E L E+ S + + Q R Q+LE++ +
Sbjct: 2660 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2719
Query: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ----SPEYENLLL 4549
F+ + WL + +++ L + + L+TQ + Q +L++ P+YE L
Sbjct: 2720 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2779
Query: 4550 T----LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4605
L R G+ PSL + + E+L A+ ++++ + D+ + +AI+ +Y
Sbjct: 2780 AGQGILSRPGED--PSLRGI----VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQY 2833
Query: 4606 ASLIELTTQSLSELEAQFLRMSKVPT-----DLAVEEALSLQDGCRAILDEVAGLGEAVD 4660
SL+ + LS+L+ + V T + +E A ++ + ++ +
Sbjct: 2834 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2893
Query: 4661 ELNQ-KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
+L+ KE + Q + +L + ++++ E V L+ ++ + ++M +
Sbjct: 2894 DLSALVKEEYLKAELSRQLEGIL---KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF 2950
Query: 4720 ERQLKSVKEEQSK---VNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD 4776
+ L + KEEQ+K ++ + E +K + + +L + ++ E+L L
Sbjct: 2951 QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL--LK 3008
Query: 4777 PLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID----FQTEMSRSLDWLRRV 4832
EKA Q+Q +K + V E E+++ +S++ ++ ++ W+ +
Sbjct: 3009 TQGSEKAALQLQ--LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 3066
Query: 4833 KAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA---KELIS 4889
+ L + L+ + + I K++ Q+E+ ++ L++ + KE+++
Sbjct: 3067 QNNLE-EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 3125
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 4949
D SL + ++ + E L +++ L + + + + +V + + L+ A+E L +
Sbjct: 3126 -DENKSLIQKVDM---VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH- 3180
Query: 4950 NGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL--DPLIKPT---GKEDLEQKV 5004
D ++ ++ T+ + L+ L L D +++ + G D+ +V
Sbjct: 3181 ---DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQV 3237
Query: 5005 ASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS 5064
++ +S+ + L+ +Q E+ + + +L + + +
Sbjct: 3238 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA- 3296
Query: 5065 HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ-------LEKTGNDASKATLSRSMTTV 5117
E L + K + E ++A + A++ E+T D + R + +
Sbjct: 3297 ----ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL--VGIKRDLEAL 3350
Query: 5118 WQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELL 5177
++ +L AQ +E+ +E + F +K+K+ + ++ + ++ ++ E
Sbjct: 3351 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGMETE 3407
Query: 5178 TLLEYHDTF-VLELEQQQSALGMLRQQTLSMLQDG---AAPTPGEEPPLMQEITAMQDRC 5233
T+ + + F V + E+ + G +QQ ++ L G +A L ++ + R
Sbjct: 3408 TINQQLNMFKVFQKEEIEPLQG--KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3465
Query: 5234 LNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIE---IDAQLE 5287
+ +KV +++ L + + S+ W+ +T+E + N P+ E + AQ++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3525
Query: 5288 ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVA-LDLK---IRDQIQ 5343
E Q LL + R++ ++ + + EK T P++ L +++ LD + + ++ +
Sbjct: 3526 E-QKLLQRLLDDRKSTVEVIKREGEKI--ATTAEPADKVKILKQLSLLDSRWEALLNKAE 3582
Query: 5344 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKL------KAKTDNVVQAKTDQKVLGEE 5397
+ +++E +Q+ ++ L + LTTI +L + + + K L ++
Sbjct: 3583 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3642
Query: 5398 LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ-AENRLSKLNQAAS 5456
+ N L + + Q + + K + + +++ I++ + +R L QA
Sbjct: 3643 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC 3702
Query: 5457 HLEEYNEMLELILKW-------IEKAKVLAHGTIA-WNSASQLREQYILHQTLLEESKEI 5508
+ + + E ++ W + K V + T W S+LR +L + +L + +
Sbjct: 3703 NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNV 3759
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEA 5568
D L E L+ T +V + + E ++ K + D AK +++
Sbjct: 3760 DQALLNGLELLKQTT--------GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3811
Query: 5569 ELKKLQAALEQAQATLTSPEVGRLSLKEQL----------SHRQHLLSEMESLKPKVQAV 5618
++L + E+ L EV LS + Q+ + L E ++ K + ++
Sbjct: 3812 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3871
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM-- 5676
SAL A L E + T Q+ + AA+++ +Q++Q
Sbjct: 3872 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADA 3931
Query: 5677 ---------KHLQQLIEGAHREIEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQIAS 5726
K L L G R +D+ A +Q+ +I RH+++ + +I +
Sbjct: 3932 ELSWITETEKKLMSL--GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3989
Query: 5727 LNSKCKMLTMKAK--------------HATMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 5772
S+ + +MK K ++ L + + L + EL P +
Sbjct: 3990 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 4049
Query: 5773 SVVMMTAGRC------------HTLL-------SPVTEESGEEGTNSEISSPP---ACRS 5810
S++ H L P ++ + G SP + +
Sbjct: 4050 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE 4109
Query: 5811 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLE-----PSATAK 5865
A+T S ++ +A++ + + + + H E E +E PS +A+
Sbjct: 4110 KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE 4169
Query: 5866 LGDLQRSWETLKNVI--SEKQRTLYEALERQ-----------------QKYQDSL----- 5901
+ ++ KNV EK + LYE L+++ + QD L
Sbjct: 4170 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4229
Query: 5902 --QSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
++I T +E E KL + E E +H +L+ I QD I +L
Sbjct: 4230 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIKDTQDFIRDL---------- 4276
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN--DQLEEQRQEQALQRY 6017
E DP S + E TIR + G ++ L+ +N +L E
Sbjct: 4277 EDPGIDP-------SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4329
Query: 6018 RCEADELDS-WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE----IEQKVVALSEL 6072
+ DEL+S W KA D + +E M Q D + + K+ ++S +
Sbjct: 4330 KKSIDELNSAWDSLNKAWKD-RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4388
Query: 6073 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6132
E + K + E+L +E++R H +L ++ +E ++
Sbjct: 4389 GTDLETV--------KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT-- 4438
Query: 6133 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 6192
VQ+ L + + W + + +Q +LE L + G+ QH+
Sbjct: 4439 --------VQDPLMELKLIWDSLEERIINRQHKLEGAL----------LALGQ---FQHA 4477
Query: 6193 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQN--VLEQEQ 6250
E +LS++ + G+ + E ++ K +LQN + Q
Sbjct: 4478 LDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL------------AKHHVLQNDVLAHQST 4525
Query: 6251 EQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIH 6307
+ + N L+ ++ S + + L+ LNQ ++ V ++ K+Q ++
Sbjct: 4526 VEAVNKAGNDLIE-------SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4578
Query: 6308 LEQKLYDGVSATSTWLDDVEERLFVATAL--LPEETETCL-FNQEILAK-DIKEMSEE-- 6361
+ + + WL D E L + L LPE + L + E+ A + KE + +
Sbjct: 4579 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4638
Query: 6362 MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6421
M K + + ++ P++ + I+ + L + +++ +N+R +++E L + F N
Sbjct: 4639 MQKGQQMLARC-PKSAETN--IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4695
Query: 6422 LKVLFTSLADNKYIILQKLANVFEQP------VAEQIEAIQQAEDGLKEFDAGIIELKRR 6475
L+ L ++ NV +P V QI+ + + + IIEL +
Sbjct: 4696 LQDFINWLTQ-----AEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4750
Query: 6476 GDKLQVEQPSMQE------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6529
G L+ L +Q +++++ + R L+ Q+ A L +
Sbjct: 4751 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4810
Query: 6530 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ--- 6586
LE EK + I + ++I+ L +HKE+ + L + + +T R S +
Sbjct: 4811 WLEE-SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4869
Query: 6587 -----KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6641
K +EL + + ++ +R +LE L + Q L L VE +
Sbjct: 4870 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4929
Query: 6642 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQL 6698
V + D +++ I ++ + L + + Q L R LI S D ++ Q+
Sbjct: 4930 AEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELIEGSRDDSSWVKVQM 4988
Query: 6699 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 6758
+L W + + RLE L+ + S L+ WL A+ L F +P
Sbjct: 4989 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRF----HGVLP 5044
Query: 6759 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT-ATLRSELSRIDSQW 6817
+ + +R ++ EF K+++ + + + + G+ +L + D+ T++ ++ I +++
Sbjct: 5045 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARF 5104
Query: 6818 TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-QKDEDNIKNSIGYKAIH 6876
++L Q++L + + + +++W+ E + KD++ I I + +
Sbjct: 5105 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI--EEVK 5162
Query: 6877 EYLQKYKGFKIDINCKQLTVDFVNQS 6902
+ +++ F ++ KQ VD V ++
Sbjct: 5163 ALIAEHQTFMEEMTRKQPDVDKVTKT 5188
Score = 245 bits (626), Expect = 1e-63
Identities = 593/3347 (17%), Positives = 1290/3347 (38%), Gaps = 356/3347 (10%)
Query: 544 EQLLQNYVSF-IENSKFFEQYEVTYQILKQTAEMYVKADG---SVEEAENVMKFMNETTA 599
E L Q Y ++ K Q++ I Q+A++ ++ G S EE E + K M E
Sbjct: 1936 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1994
Query: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH 659
+ E + + +++ + WL+ +E+ L E D +
Sbjct: 1995 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 2054
Query: 660 WIQQHTAMND-------------AGNFLIETCDEMVSRD------------LKQQLLLLN 694
+Q + D +GN ++E RD ++++L
Sbjct: 2055 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 2114
Query: 695 GRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNV 749
R+R L+ + D+ + + L A A K LSEP+ V N+
Sbjct: 2115 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 2174
Query: 750 KLLIQDLEDIEQRVPVMDAQYKIITKTAHLI---------------------------TK 782
+ +++ + ++ ++ + + KTA ++
Sbjct: 2175 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2234
Query: 783 ESPQEEGKEMFATMSK-------LKEQLTKVKECYSPLLYESQQLLIPLEE--------- 826
+S E +++ T+++ L E L + S L + Q +PL
Sbjct: 2235 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ---VPLNSTALQDIISK 2291
Query: 827 ---LEKQMTSFYDSLGKINEII-------------TVLEREAQSSALFKQ---KHQELLA 867
LE+ + S+ +NE + ++ + SA F + KH+E LA
Sbjct: 2292 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2351
Query: 868 CQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWK 926
E K + L E S+ +Q F+ T + L D + + ++ Q + + K
Sbjct: 2352 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP--GKDVTELSQYMQESTSEFLEHK 2409
Query: 927 KHVETNSRLMKKF------EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQ- 979
KH+E L+K+ + LEK ++++ E + +E T QLD
Sbjct: 2410 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2469
Query: 980 RVLNAFLKA-CDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRF 1038
+VL LK+ E T +P + E + K + K LQ + ++
Sbjct: 2470 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2529
Query: 1039 LASVEECRTELDRETKLMPQEGS----EKIIKEHRVFFSDKGPHHLCEKRLQL---IEEL 1091
L ++ T + + G+ E F+++KG + + + E+L
Sbjct: 2530 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2589
Query: 1092 CVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1151
+ L + +T + +E +A+ +K+ + KW+ + + + T
Sbjct: 2590 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD--TEAVKTQV 2647
Query: 1152 TQLKGIKGEAIDTANH-GEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQ 1210
Q K + E N E+K + E+ E W ++LTE+ S+ + Q
Sbjct: 2648 EQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW----KQMLTEIDSKWQELNQ 2703
Query: 1211 --GDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEK 1268
D KL S L T VE L + + KE++ + L L + Q ++
Sbjct: 2704 LTIDRQQKLEESSNNL-TQFQTVEAQLKQW---LVEKELMVSVLGPLSIDPNMLNTQRQQ 2759
Query: 1269 ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD-----RG--HEEL 1321
+ Q+LL A ++ +Q+ A QG P RG E+L
Sbjct: 2760 V----------QILLQE-------FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2802
Query: 1322 RKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL-- 1379
+ D L + I + K T ++++R L S + LS SSL
Sbjct: 2803 AAVTQKWDSLTGQLSDRCDWIDQAIVK----STQYQSLLRSLSDKLSDLDNKLS-SSLAV 2857
Query: 1380 ----ESLSSELEQTKEFSKRTESIAVQ---AENLVKEASEIPLGPQNKQLLQQQAKSIKE 1432
++++ +LE ++ + + Q A+ L ++ S + K L +Q + I +
Sbjct: 2858 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2917
Query: 1433 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1492
K +E E ++ ++ F W+ K++E N S+ +D+ S
Sbjct: 2918 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2977
Query: 1493 IKVTIQEIESKLSSIVGLEE----EAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQ 1548
IK ++ L++ + E E ++ E A ++ +L I+ + + +
Sbjct: 2978 IK-DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVK 3036
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATE------TYKVLQEH 1602
E + L + K++E + + + + ++ L IK C E K LQ+
Sbjct: 3037 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKLKSLQKE 3095
Query: 1603 MDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLA 1662
MD + L + TA S + ++++ E +L Q+ + + + ++ LEN+
Sbjct: 3096 MDQHFGMVELLNN-TANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQ 3154
Query: 1663 HWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK 1722
++ ++ +K S ++ + +++ + L QA N+ ++ K
Sbjct: 3155 KFKEFQE------------VSKESKRQLQCAKEQLDIHDSLG-SQAYSNKYLTMLQTQQK 3201
Query: 1723 LLQ------------LKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSV 1770
LQ ++ + + + L +E + + L Q ++++ +FL++
Sbjct: 3202 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3261
Query: 1771 VAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSL 1830
+ F + F EL + + + + A T K + E+ K L+ L
Sbjct: 3262 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVG----RDAETLQK----QKETIKAFLKKL 3313
Query: 1831 QGHLAKLGSLGRAEDLHL--------LQGKAEDCFQLFEEASQVVERRQL-------ALS 1875
+ +A + + + L L G D L ++ +++++R Q +
Sbjct: 3314 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3373
Query: 1876 HLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDG 1935
L EF S +L++ + E+ + E++ I + LN K ++
Sbjct: 3374 RLEEFYSKLKEFSILLQKAEEHEESQGPVGM-ETETINQQLNMFKVFQKE------EIEP 3426
Query: 1936 ILSKAQYHLKIGSSEQRTSCRATADQ-LCGEVERIQNLLGT-KQSEADALAVLKKA---- 1989
+ K Q +G +++ ++T+ Q L +++ + T + A A L++A
Sbjct: 3427 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3486
Query: 1990 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2047
FQD E LL + D EE ++ + ++ +++ L+ L+ + + +K
Sbjct: 3487 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3546
Query: 2048 KAKQIA-QKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVS 2106
+ ++IA + A ++ ++++ L+ W+ Q G+ + +++ ++
Sbjct: 3547 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3606
Query: 2107 KVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKK 2165
+ L +V I Q L+ ++H+ ++ + K L S G+ L K
Sbjct: 3607 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-----K 3661
Query: 2166 IHSS--DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE--GWSN 2221
+ SS D +V++ ++ + ++++ EK + L+ +L + + DE+E W N
Sbjct: 3662 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLN 3719
Query: 2222 NCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLE----T 2277
++ + +S L + E L + +SE+ + L+ + L K N + L LE T
Sbjct: 3720 ----EVHDKLSKLSVQDYSTEGLWKQQSEL--RVLQEDILLRKQNVDQALLNGLELLKQT 3773
Query: 2278 PPDLQFIEADLMQKL-----EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2332
D I D ++ + + K T+VAK TL+ + ++ ++ TW KVE
Sbjct: 3774 TGDEVLIIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTHEELCTWLDKVEV 3832
Query: 2333 SLMN-----CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGR 2387
L++ E +A + K+++KE ++ ++ + S E ++L E L +
Sbjct: 3833 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3892
Query: 2388 AMTGLIKKHEAVSQLCSKTQASLQESL--EKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
+ +++ VS ++ + ++ + F ++ W + D +
Sbjct: 3893 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3952
Query: 2446 SKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQA 2505
A+L + + + +D + + G + S++ S+++++ K + +
Sbjct: 3953 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 4012
Query: 2506 FLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2565
+ + L+ S + F + + +L W+ E + + + ++ E H
Sbjct: 4013 ICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEH 4072
Query: 2566 KVEMFLGELLAA-RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLR 2624
+ L EL+A + +DK+++ G L E G EG + + L KE ++
Sbjct: 4073 RQ---LRELIAEHKPHIDKMNKTGPQLLELSPG---EGFSIQEKYVAADTLYSQIKEDVK 4126
Query: 2625 SCQVALQE--------HEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
VAL E H+ +++ L+S+ + I +RL S + +++++S+ ++
Sbjct: 4127 KRAVALDEAISQSTQFHDKIDQILESL----ERIVERLRQPPSISAEVEKIKEQISENKN 4182
Query: 2677 ILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ----RVIQTQLETLKEVWADIMSSSVHAQ 2732
+ + + + +GE+ + S + + +Q +L+ + +W +I + +
Sbjct: 4183 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242
Query: 2733 STLESVISQ----WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
+ L V+ W D++ ++ + + + + P +++ + ++I
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQ----EAAETIRE 4298
Query: 2789 EAEDHTRALHRLIAKSRELYEK--TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIV 2846
E + L +I EL D+ + +EL + ++ + K+++ K+EE +
Sbjct: 4299 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4358
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELID---SREIGASR 2903
+ + Y D + DW+ A +L S + D ++++ ++K+ ++I R
Sbjct: 4359 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4418
Query: 2904 LSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2963
L+ L +K+ T S + + L+ W E+ + Q LE + +
Sbjct: 4419 LNHQAELL--LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL----- 4471
Query: 2964 EFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3023
Q + AL++ A L L+ + D + +E +L A T
Sbjct: 4472 ------GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4525
Query: 3024 -EDLKSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRK 3078
E + N+L S + S K+ L + + + + + Q + L+Q F
Sbjct: 4526 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4585
Query: 3079 AFRDFQQWLVNAK---ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3135
D QQWL + + + + +P+ E L E + E + ++ KG
Sbjct: 4586 EIEDLQQWLTDTERHLLASKPLGGLPETAKE---QLNVHMEVCAAFEAKEETYKSLMQKG 4642
Query: 3136 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3195
+ + K I + KE W++ + L+++++ LE +F S + +W
Sbjct: 4643 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4702
Query: 3196 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL--WEGQAA 3253
L++ E+ ++ +S L + + + E++ + Q+ L + L + +
Sbjct: 4703 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4762
Query: 3254 SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY 3313
++ + + S++ + E+ LD QF +L +W+ ++ LDS
Sbjct: 4763 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4822
Query: 3314 CHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS-PEGIPTIQQQLQS 3372
+D + ++ + + K G S+ + TS + + L
Sbjct: 4823 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4882
Query: 3373 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3432
++D W ++ + +++LE AL + D ++ W+ +E L E + H ++
Sbjct: 4883 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4942
Query: 3433 TTMLGKAKLLNEEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQER 3486
++ K +E+ +S ++ ++ ++G+ +V ++++Q+L R+ +
Sbjct: 4943 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV-KVQMQELSTRWETVCAL 5001
Query: 3487 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3546
+ T+ E +R +E+ + A WL + ++ L + VL D T + +E
Sbjct: 5002 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 5061
Query: 3547 VHCAEGQALLNSVLHTREDVI----PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
E +A LN + V+ P I + + +R ++ + + + +
Sbjct: 5062 KKLEEKRAELNKATTMGDTVLAICHPDSITTIK-HWITIIRARFEEVLAWAKQHQQRLAS 5120
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQE 3649
+ L ++ + + WL+ AE ++ E+EEV A E
Sbjct: 5121 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 5167
Score = 239 bits (611), Expect = 7e-62
Identities = 867/4747 (18%), Positives = 1760/4747 (37%), Gaps = 818/4747 (17%)
Query: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2242
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 769 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 824
Query: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2299
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 825 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 870
Query: 2300 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2355
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 871 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 925
Query: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 926 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 976
Query: 2416 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2463
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 977 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 1035
Query: 2464 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2502
+S + + + +T+ + +I ++ AN
Sbjct: 1036 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 1095
Query: 2503 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2542
+A K C ++ E Q++ L LW HE
Sbjct: 1096 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 1154
Query: 2543 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2592
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 1155 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1208
Query: 2593 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1209 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1261
Query: 2652 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2702
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1262 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1320
Query: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2762
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1321 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1375
Query: 2763 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2821
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1376 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1431
Query: 2822 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1432 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1491
Query: 2871 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2929
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1492 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1549
Query: 2930 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2989
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1550 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1595
Query: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1596 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1636
Query: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1637 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1690
Query: 3110 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3156
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1691 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1750
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3210
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1751 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1810
Query: 3211 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3258
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1811 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1865
Query: 3259 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3308
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1866 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1925
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3363
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1926 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1982
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1983 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 2042
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3465
++ T L + K +E+V+S+ L I + G + E
Sbjct: 2043 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 2102
Query: 3466 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3518
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 2103 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2162
Query: 3519 ------------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALL----NSVLHT 3562
Q +L++ L+G + + + L++ + + L N + T
Sbjct: 2163 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2222
Query: 3563 REDVI------PSGIPQAEDRALESLRQ------------DWQA-------YQHRLSETR 3597
+D++ + + ++ +L + DW Q ++
Sbjct: 2223 LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNS 2282
Query: 3598 TQFNNVVNKLRLMEQ-------KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEI 3650
T ++++K ++EQ ++E +K E ++ + +++++ AR E
Sbjct: 2283 TALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE- 2341
Query: 3651 LDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH 3710
SH + + +L ++ +E + L E++Q+ E+++ + D G
Sbjct: 2342 --ASHKHKETLAKMEELKTK--------VELFENLSEKLQTFLETKTQALTEVDVPG--- 2388
Query: 3711 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770
K+ ++ + + + + K K LEVL HSLLK G + K L +
Sbjct: 2389 KDVTELSQYMQESTSEFLEHK-KHLEVL-------HSLLKEISSHGLPSDKALVLEKTNN 2440
Query: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
L K + KE+ T++++ + F K+L WI E + + + +P
Sbjct: 2441 LSK-------KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQP 2492
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK-IDQLQSDYQ 3889
+ L K LQ+ P ++ V G +L L+ VT K I ++S
Sbjct: 2493 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2552
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
L G A E L +++ K T I + L LK +
Sbjct: 2553 VLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI-------------- 2597
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL-----SAVQPDLEPSPQPPLSRAEAIKQ 4004
L +L K Q+ WL +A + P+P + ++Q
Sbjct: 2598 --------AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2649
Query: 4005 VKHFRA-LQEQARTYLDLLCSMCDLSNASVKT-TAKDIQQTEQTIEQKLVQAQNLTQGWE 4062
K F A L++ +L + +L + T A +Q I+ K W+
Sbjct: 2650 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK----------WQ 2699
Query: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELE---------------LNIAQNMVSQVKDF 4107
E+ L + L+++ L + ++L+ L+I NM++ +
Sbjct: 2700 ELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2759
Query: 4108 VKKLQSKQASVNTIIEKVNK-----LTKKEESPE-----HKEINHLNDQWLDLCRQSNNL 4157
V+ L + A+ E++ L++ E P +++ + +W L Q ++
Sbjct: 2760 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2819
Query: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER 4217
C ++ + ++ Y + + +K + + L+ S A ST H +A+ + Q+
Sbjct: 2820 CDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVST--HPDAMNQQLETAQKM 2874
Query: 4218 KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK------RKIQVSVTN 4271
K I+ K Q K+ + L D LVKE+ E QLE ++K +K + V +
Sbjct: 2875 KQEIQQEKKQ-IKVAQALCEDLSALVKEEYLKAELS-RQLEGILKSFKDVEQKAENHVQH 2932
Query: 4272 LEELNVVQSRFQEL----MEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327
L+ +FQ++ W + ++ ++ S D+ ++L+ DH L A+
Sbjct: 2933 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS 2992
Query: 4328 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR----RKYLNKALSE 4383
+ + I + + ++ +E+ +Q L+ +++ + + V +R ++ L KAL
Sbjct: 2993 HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY 3052
Query: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443
K Q + ++ + Q + +I F CL P + + KS Q + + V L
Sbjct: 3053 KEQ-VETLWPWIDKCQNNLEEIKF----CLDPAEGENSIAKLKSLQKEMDQHFGMVELLN 3107
Query: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
L+ V E +K V + + L D V ++ + LE K F+E ++
Sbjct: 3108 NTANSLL-SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 3166
Query: 4504 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563
L+ A E ++H L S Y N LT+ +T Q
Sbjct: 3167 KRQLQCA-----------KEQLDIHDSLG--------SQAYSNKYLTMLQTQQ------- 3200
Query: 4564 EVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEA-----ILAR-----KEYASLIELTT 4613
+ L AL Q ++ LA+D + ++ +L + +E+++L +
Sbjct: 3201 --------KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3252
Query: 4614 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR--- 4670
+ S LE + + + E S LD +A +G + L ++KE +
Sbjct: 3253 EKCSFLETKLQGIGHFQN--TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3310
Query: 4671 --------STGQPWQPDKML--------HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK 4714
S + KM+ LV + L+ ++Q LL+ + ++ E
Sbjct: 3311 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3370
Query: 4715 MCQQLERQLKSVK-------------EEQSKVNEETLPAEEKLKMY--------HSLAGS 4753
++LE +K E Q V ET ++L M+ L G
Sbjct: 3371 TIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3430
Query: 4754 LQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMV 4813
QD + + + ++ A E H + K L + + + + ++
Sbjct: 3431 QQDVNWLGQGL---IQSAAKSTSTQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALL 3484
Query: 4814 QSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL 4873
FQ + L W+ + ++ + ++ +I++ ++ Q + + +
Sbjct: 3485 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3544
Query: 4874 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQV 4930
+E EK E AD L +LS LD + L TR L I Q++++
Sbjct: 3545 K-REGEKIATTAE--PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3601
Query: 4931 FQAANDWLEDAQE-LLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 4989
+ N+WL ++ L+ G EE + H + ED ++ + LH V+
Sbjct: 3602 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQ 3658
Query: 4990 PLIKPTGKEDLEQKVASLELRSQ---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5046
L + +ED + + L+ + S ++ +LLQ+ + + E++ +
Sbjct: 3659 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3718
Query: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
N+ KLS+ S ++ S+ ++ SE + L E I+ ++ Q G +
Sbjct: 3719 NEVHDKLSKLS-VQDYSTEGLWKQQSELRVL-------QEDILLRKQNVDQALLNGLELL 3770
Query: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
K T + + + ++A +D K+ D V K E QL +L
Sbjct: 3771 KQTTGDEVLIIQDKLEAIKARYKDITKLSTD-----------VAKTLEQALQLARRL--- 3816
Query: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
++ EL T L+ + +L E Q GEE
Sbjct: 3817 ---HSTHEELCTWLDKVEVELLSYETQ--------------------VLKGEE------- 3846
Query: 5227 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQL 5286
+ + K +K+E K+ + + +N E+ + L
Sbjct: 3847 ----------ASQAQMRPKELKKEAKNNKALLDSLN------------------EVSSAL 3878
Query: 5287 EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKI 5346
EL R+ +EKM E E+Y L S+ Q E +R Q D+
Sbjct: 3879 LEL-----VPWRAREGLEKMVAEDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQA 3928
Query: 5347 KEVEQSKATSQE---LSRQIQKLAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCN 5402
+ E S T E +S +L +D T+ L K T +++ K + ++L
Sbjct: 3929 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSG 3984
Query: 5403 SKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN 5462
K+M + +K + + KK+ K+ + + + R +L +A S + ++
Sbjct: 3985 HKIMTACSEEEK---------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 4035
Query: 5463 EMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521
E E + W+ E +++ LR+Q H+ L E E ++ M +
Sbjct: 4036 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 4095
Query: 5522 LTSVYCTEKMSQQVAELGRET--EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
L + E S Q + +T ++++ +K R L +A +F ++ ++ +LE+
Sbjct: 4096 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 4155
Query: 5580 AQATLTSP-----EVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA- 5633
L P EV + +KEQ+S +++ +ME L+P L ++ + E+++A
Sbjct: 4156 IVERLRQPPSISAEVEK--IKEQISENKNVSVDMEKLQP------LYETLKQRGEEMIAR 4207
Query: 5634 --SLPLCHAALRLQEEASRLQ------HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIE 5684
+A +Q++ ++ HT +++ V++ E++ + L I+
Sbjct: 4208 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4267
Query: 5685 GAH---REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
R++ED + S +++ Q E + ++I G QE++ + + L
Sbjct: 4268 DTQDFIRDLEDPGIDPSVVKQQQ---EAAETIREEIDGLQEELDIVINLGSELIAACGEP 4324
Query: 5742 TMLLTVTEVEGLAEGTEDLD----GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797
+ ++ L + L+ + A + V G + V G+
Sbjct: 4325 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK-- 4381
Query: 5798 TNSEISSPPACRSPSPVANTDASVNQDI---------AYYQALSAERLQTDAAKIHPSTS 5848
S SP+ +V Q I AY Q + ERL H +
Sbjct: 4382 ----------LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN------HQAEL 4425
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
++ E + + L +L+ W++L+ I +Q L AL ++Q +L + +
Sbjct: 4426 LLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4485
Query: 5909 EAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
E LSE G P E ++A+H L +++L Q + E + +L+ S +
Sbjct: 4486 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEE 4544
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ+ L VL +R + K ++Q L+ L RQ + + E ++L
Sbjct: 4545 ASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQ 4591
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL T+ L + P + QL + E K L + +L
Sbjct: 4592 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4651
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQ 6142
+ +Q + LK ++ L++++ ++ A E S D
Sbjct: 4652 SAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI-------- 4700
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE 6202
WL QA T + SL L Q + E K V S E+I+ +
Sbjct: 4701 NWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4759
Query: 6203 KPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL 6262
K DV+ + + ++ +WE + Q + + L + ++ ++ + ++L+
Sbjct: 4760 KQDVVLIK--------NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLM 4809
Query: 6263 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATS 6320
+ + + ++ S L+ N +++ +Q K ++S+ + +YD + T
Sbjct: 4810 EWL--------EESEKSLDSELEIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
L E+T LA D ++ + + + ++ + ++ + +
Sbjct: 4861 --------------RSLKEKTS--------LADDNLKLDDMLSELRDKWDTICGKSVERQ 4898
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ +E+ L G+ + + ++++ +L + D+ ++ + ++K
Sbjct: 4899 NKLEEAL-LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHK------- 4950
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
F++ + ++ ++Q + +E G R D V + MQELS ++ +
Sbjct: 4951 --AFQKELGKRTSSVQALKRSARELIEG-----SRDDSSWV-KVQMQELS---TRWETVC 4999
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHK 6560
+ S+++ L L ++ + L + L ++ + ++ ++ ++ L+D+HK
Sbjct: 5000 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHK 5058
Query: 6561 EYFQGLE 6567
E+ + LE
Sbjct: 5059 EFMKKLE 5065
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 507 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 558
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2592 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2651
Query: 559 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 614
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2652 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2711
Query: 615 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 661
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2712 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2771
Query: 662 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 718
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2772 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2831
Query: 719 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 768
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2832 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2891
Query: 769 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 821
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2892 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2951
Query: 822 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 878
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2952 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 3007
Query: 879 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 938
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 3008 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 3065
Query: 939 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 996
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 3066 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 3124
Query: 997 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1053
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 3125 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3181
Query: 1054 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1113
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3182 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3236
Query: 1114 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1171
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3237 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3296
Query: 1172 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1231
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3297 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3347
Query: 1232 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1272
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3348 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3406
Query: 1273 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1328
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3407 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3465
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1386
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3466 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3524
Query: 1387 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1444
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3525 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3584
Query: 1445 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1501
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3585 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3644
Query: 1502 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1561
+ + QS + + +++KL + + E++E + + L
Sbjct: 3645 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3704
Query: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1614
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3705 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3761
Query: 1615 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1672
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3762 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3821
Query: 1673 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1732
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3822 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3880
Query: 1733 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3881 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3940
Query: 1793 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3941 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 4000
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 4001 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 4059
Query: 1907 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1964
E + + + + Q + + +D + L++ E AD L
Sbjct: 4060 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 4119
Query: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2024
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 4120 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 4176
Query: 2025 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2078
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4235
Query: 2079 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2128
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4236 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4286
Query: 2129 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2184
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4287 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4346
Query: 2185 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2244
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4347 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4402
Query: 2245 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2301
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4403 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4459
Query: 2302 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2356
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4460 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 2357 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2415
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4579
Query: 2416 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4580 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4639
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4699
Query: 2535 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2594
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4700 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4755
Query: 2595 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2650
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4815
Query: 2651 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2709
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4816 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4875
Query: 2710 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2769
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4876 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4935
Query: 2770 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2828
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4936 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4995
Query: 2829 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2888
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4996 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 5055
Query: 2889 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2948
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 5056 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 5112
Query: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 5113 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 5155
Query: 3009 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3054
QEI E++K+ + E F +++ V + K Y
Sbjct: 5156 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5189
Score = 203 bits (517), Expect = 5e-51
Identities = 144/436 (33%), Positives = 219/436 (50%), Gaps = 72/436 (16%)
Query: 20 RLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQ 79
R+ DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG LP E+
Sbjct: 206 RIADERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTLPREK 263
Query: 80 GRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILY 139
GR R H + N+ AL +L+ R+ +KLVNI + DI DG P + LGL+WTIIL+
Sbjct: 264 GRM--RFHRLQNVQIALDYLKRRQ-------VKLVNIRNDDITDGNPKLTLGLIWTIILH 314
Query: 140 FQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTA 199
FQI ++ V+ E+ +AK+ LL W Q
Sbjct: 315 FQISDIH-------------------VTGESEDM------------SAKERLLLWTQQAT 343
Query: 200 GKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGI 259
GI ++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE ++G+
Sbjct: 344 EGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGV 402
Query: 260 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 319
RLLDPEDVDV PDEKS++TYV+ +P + +G +++ + + N V
Sbjct: 403 IRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNMVNYL 461
Query: 320 KREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQIEHL 375
+ R M ER + L ++Y FK + + K K++ L
Sbjct: 462 IQWIRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKL 515
Query: 376 IQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREE 435
++ G++ L Q ++ +W G + + E ALR E
Sbjct: 516 LEIWIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKALRPE 557
Query: 436 ITVQQVHEETANTIQR 451
+ ++ ++ AN +QR
Sbjct: 558 VERLEMLQQIANRVQR 573
Score = 170 bits (430), Expect = 7e-41
Identities = 619/3344 (18%), Positives = 1264/3344 (37%), Gaps = 595/3344 (17%)
Query: 5604 LLSEMESLKPKVQAVQLCQS-ALRIPED-VVASLPLCHAALRLQEEASRLQHTAIQQCNI 5661
+L ++L+P+V+ +++ Q A R+ D V+ L A LQ ++ RL+ + +Q N
Sbjct: 547 MLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE-SGVQFQNE 605
Query: 5662 MQAA--VVQYEQY-EQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIK 5718
+ A +++ E Q + +Q LI+G + + + +L Q++
Sbjct: 606 AEIAGYILECENLLRQHVIDVQILIDGKYYQAD--------------------QLVQRVA 645
Query: 5719 GYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEG-------------TEDLDGELL 5765
+++I +L ++C + K + T T + G+ + T L L
Sbjct: 646 KLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLT 705
Query: 5766 PTPSAHPSVVMMTAGRCHTLLSPVTE--------------ESGEEGTNSEISSPPACRSP 5811
P+ ++ +++G L VT SG E + + R P
Sbjct: 706 PSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKP 765
Query: 5812 SPVAN------TDASVN----QDIAYY---QALSAERLQ--TDAAKI------HPSTSAS 5850
++ T+ +N QD+ + + +R + +D + H + +
Sbjct: 766 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA 825
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTL---YEAL----ERQQKYQDSLQS 5903
E +E L+ AK+ ++Q + LK +EK L Y L Q+++ D+L +
Sbjct: 826 IEEFESSLKE---AKISEIQMT-APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN 881
Query: 5904 ISTKM--EAIELKLSESPEPGRSPESQMAE-------HQALMDEILMLQDEINELQSSLA 5954
++ E I L E E + H LM E+ ++ I +Q +A
Sbjct: 882 FVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQE-IA 940
Query: 5955 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK------LNDQLEE- 6007
E+L+ E+ A +L +++ + + S I Q ++E ND E
Sbjct: 941 EQLLLENHPA----RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 996
Query: 6008 ---QRQEQALQR-YRC--------------EADELDSWLLSTKATLDTALSPPKEPMDME 6049
+ + A+QR Y C E+ E LL K+T+ + K + ++
Sbjct: 997 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLK 1056
Query: 6050 AQLMDCQNMLVEIEQKVVA---LSELSVHNEN-LLLEGKAHT------------------ 6087
+ DC + I K + E++++ ++ +L +H
Sbjct: 1057 PRNSDCP-LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 1115
Query: 6088 -------KDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ---------EKEESDV 6131
EA LA ++ + ++L L H+ +NM+ S+V
Sbjct: 1116 CFTVPPPNKEAVDLANRIEQQYQNVLTLW---HESHINMKSVVSWHYLINEIDRIRASNV 1172
Query: 6132 DLTATQSPGV-QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ 6190
T PG Q+ L+ ++ + + S + Q ++ + + + +E+L
Sbjct: 1173 ASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS 1232
Query: 6191 HSAAETSGDAGEK--PDVLSQELGMEGEKSSAEDQMR--MKWESLHQEFS--TKQKLLQN 6244
E +V + L +E + Q+R ++ + LH+ T+Q+ L+
Sbjct: 1233 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 1292
Query: 6245 VLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 6302
LE+ ++ + + ++ S VPT +S + +L +NQ + S+ K
Sbjct: 1293 ELERLKDDLGTITNKCEEFFSQAAA-SSSVPTL-RSELNVVLQNMNQVYSMSSTYIDKLK 1350
Query: 6303 RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEM 6362
++ L+ A + E +L A++ ++ N E L +K+ E+
Sbjct: 1351 TVNLVLKN-----TQAAEALVKLYETKLCEEEAVIADKN-----NIENLISTLKQWRSEV 1400
Query: 6363 DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQ----QILNF 6418
D+ + +F A + I D + L ++ Q+ ER Q QI N
Sbjct: 1401 DEKRQVF-HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1459
Query: 6419 QNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRG 6476
DL+ + SL KY L + +Q Q + + + K + + K
Sbjct: 1460 LRDLEGIGKSL---KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1516
Query: 6477 DKLQVEQPSMQELSKLQDMYDELMM-----------IIGSRRSGLNQNLTLKSQYERALQ 6525
+++++Q M E K + Y + ++ S++ + ++S + +Q
Sbjct: 1517 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1576
Query: 6526 DLADL---------LETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ DL L T K AGD + +EE + L ++ KE+ +
Sbjct: 1577 EFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEEEKSLEEEKKEHVEKA---------- 1624
Query: 6577 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV 6636
KE Q + ++ S LK A K G +S +E+S + E
Sbjct: 1625 ----------KELQ---KWVSNISKTLKDAEKAGKP------PFSKQKISSEEISTKKEQ 1665
Query: 6637 VESSIPSVGL-VEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLE 6695
+ ++ ++ L + ++ D++ D NE + K + L + LL S S
Sbjct: 1666 LSEALQTIQLFLAKHGDKMTDE---------ERNELE-KQVKTLQESYNLLFSES----- 1710
Query: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6755
L QL E S K+ +++ + + Y+ + + L ++RL Q++
Sbjct: 1711 --LKQLQESQTSGDVKVEEKI-----VAERQQEYKEKLQGICDLLTQTENRL-IGHQEAF 1762
Query: 6756 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATLRSEL 6810
+ ++ + + E K++ + + V+ L+ L + D A + +L
Sbjct: 1763 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1822
Query: 6811 SRIDSQWTDLLTNIPAVQEKLHQLQMDKL-------------------PSRHAISEVMSW 6851
+ + L N+ A Q K ++DK+ S+ I ++ W
Sbjct: 1823 NEAKIKCEQL--NLKAEQSKK---ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1877
Query: 6852 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYK---GFKIDINCKQLTVDFVNQ--SVLQI 6906
+S ++ ++ K I H K G + ++N L D Q + +
Sbjct: 1878 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1937
Query: 6907 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTW 6966
+Q + ++ Q A+ + Q Q L+ ++ Q L E + + N++ LK
Sbjct: 1938 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP--EEKEKLQKNMKELKVH 1995
Query: 6967 FET----QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLAL 7017
+ET EK++K H + ++ +A D + E ++ E+E+E +E NGL
Sbjct: 1996 YETALAESEKKMKLTHSLQEELEKFDA--DYTEFEHWLQQSEQELENLEAGADDINGLMT 2053
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLK---SVLDQWSSHKVAFDKINSY 7074
+++ S V+S +L + + ++ K K +D ++H+ K++
Sbjct: 2054 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD-- 2111
Query: 7075 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 7134
++ RFR L + +NL++L D + E + G + L+ C
Sbjct: 2112 -----HATDRFRSLYSKCNVLG---NNLKDLVDKYQHYEDA--SCGLLAG--LQACEATA 2159
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7194
++ L+ + + + QL+ +KAL + Q+ +L
Sbjct: 2160 SKHLSEPIAVDP-------KNLQRQLEETKAL--------------QGQISSQQVAVEKL 2198
Query: 7195 LKAATNKDIADDEVATWIQDCNDLLKGL----GTVKDSLFFLHELGEQLKQQVDASAASA 7250
K A ++ D + + ND+ K L G +D ++E E+L
Sbjct: 2199 KKTA---EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL----------- 2244
Query: 7251 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL--QGQD 7308
Q++L++ L S+Q G L+ + W+ E L QGQ
Sbjct: 2245 ----QITLTRSL------------SVQDG----------LDEMLDWMGNVESSLKEQGQV 2278
Query: 7309 PSHSSDLSTIQERM----EELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 7364
P +S+ L I + +++ G+ ++M + + E + + K M++L+
Sbjct: 2279 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK-MKDLSA 2337
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7421
+S S + E +K++ + + F EK +T++E +T+ V++ G L
Sbjct: 2338 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE--TKTQALTEVDVPGKDVTELS 2395
Query: 7422 QQRAHELFQ-AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7480
Q + E ++LHS++ + + G D+ K LS +++ +
Sbjct: 2396 QYMQESTSEFLEHKKHLEVLHSLL---KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2452
Query: 7481 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS-----YLPMSGLGSVPIPLQQARTLFDE 7535
++++ + S Q ++ + + L+ W+ E + P G + L+ + L ++
Sbjct: 2453 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2512
Query: 7536 VQFKEKVFLRQQGSYI-------LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM 7588
K + S I K + GA + +E W A+
Sbjct: 2513 WSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW--ANK 2570
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
L KK + + +E + D + +L T KL ++ EE A +++
Sbjct: 2571 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA----QEESSAMMQWLQKMNK 2626
Query: 7649 AVGSW------TD--------------------DLTQLSLLKDTLSAYISAD----DISI 7678
W TD ++ ++ LKD L+ + + +
Sbjct: 2627 TATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPR 2686
Query: 7679 LNERVELLQRQWEELCHQLSLRRQQ-IGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7737
+ + + +W+EL +QL++ RQQ + E N F +L +WL + E VS G
Sbjct: 2687 WKQMLTEIDSKWQEL-NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2745
Query: 7738 ILIE-EMIEKLKKDYQ---EEIAIAQENKIQLQQMGERLAKASHESKASE--IEYKLGKV 7791
+ I+ M+ ++ Q +E A + QL G+ + E + ++ +L V
Sbjct: 2746 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2805
Query: 7792 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI 7851
+W L ++ R + + +V Q + SL L+ ++++L+ + S + + +
Sbjct: 2806 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV-STHPDAM 2864
Query: 7852 QRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD-----------SIQQ 7900
++L Q+++++I++ + LCE L AE ++Q
Sbjct: 2865 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2924
Query: 7901 ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
N + ++ CA S + ++ R +Q +LD K E+ + P S+ +
Sbjct: 2925 KAENHVQHLQSACASSHQ----FQQMSRDFQAWLDT--------KKEEQNKSHPISAKL- 2971
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN 8020
V + +K + F + + E + L + + +L+ ++ WD
Sbjct: 2972 -DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 3030
Query: 8021 LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH-FSECDVQAKIKQLK 8079
K+V +LK + + +++ +++ W+ + L I+ + + I +LK
Sbjct: 3031 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLK 3090
Query: 8080 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK- 8138
+ Q+E+ + +E + L+ E +D ++ DE + Q+V E+ H K
Sbjct: 3091 SLQKEMDQHFGMVELLNNTANSLLSVCE-IDKEVVT---DENKSLIQKVDMVTEQLHSKK 3146
Query: 8139 --LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS 8196
L + E +E + + A L HD L Q SN L++ Q +
Sbjct: 3147 FCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDS-----LGSQAYSNKYLTMLQTQQK 3201
Query: 8197 ERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDV 8256
S+ ++ H DL++ L + E D K G SDV
Sbjct: 3202 ---------SLQALK----HQVDLAKRLAQDLV-------VEASDSK--------GTSDV 3233
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR------- 8309
++ ++ + +HS L Q+ + L+ I +N IR
Sbjct: 3234 LLQ-------------VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3280
Query: 8310 -------SKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 8356
S P G + +T + K ++K L +S D+ + + EE+ P
Sbjct: 3281 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3340
Query: 8357 V----NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8412
V +L + Q ++DR A ++E +++ +++ ++F S L L E
Sbjct: 3341 VGIKRDLEALSKQCNKLLDR-------AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3393
Query: 8413 EELEQLQRLELSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQ--ADSKES 8469
E E + + T+ TI Q+ K QK ++ + +N Q A S +
Sbjct: 3394 EHEESQGPVGMETE--TINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3451
Query: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
+ L+ L +N RW + + + LQ+AL+ C F + LL + + +
Sbjct: 3452 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3511
Query: 8530 PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHV 8589
P + Q ++L+Q + +S + V + ++ AE D ++ +++ +
Sbjct: 3512 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE--KIATTAEPADKVKILKQLSL 3569
Query: 8590 IGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADE 8629
+ +R + LL + ++LE + V+ + + L+ W + E
Sbjct: 3570 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE 3613
Score = 159 bits (401), Expect = 2e-37
Identities = 417/2207 (18%), Positives = 833/2207 (37%), Gaps = 317/2207 (14%)
Query: 6668 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1187 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1244
Query: 6728 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6771
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1245 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1304
Query: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6831
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1305 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1349
Query: 6832 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6889
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1350 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1400
Query: 6890 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 6943
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1401 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1460
Query: 6944 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1461 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1520
Query: 7002 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7059
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1521 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1580
Query: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7108
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1581 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1640
Query: 7109 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7146
EK + S QK S KE +T L +K +
Sbjct: 1641 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1700
Query: 7147 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7190
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1701 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1760
Query: 7191 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1761 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1814
Query: 7244 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7293
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1815 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1874
Query: 7294 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7318
W+ ++ + H + T
Sbjct: 1875 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1934
Query: 7319 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7364
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1935 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1994
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7422
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1995 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 2054
Query: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7470
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 2055 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 2114
Query: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7530
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 2115 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 2173
Query: 7531 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7583
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 2174 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2230
Query: 7584 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7641
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2231 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2290
Query: 7642 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7698
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2291 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2350
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2351 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2405
Query: 7759 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7817
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2406 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2464
Query: 7818 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7867
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2465 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2522
Query: 7868 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7905
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2523 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2582
Query: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 7964
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2583 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2642
Query: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8022
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2643 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2702
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--VQAKIKQLKA 8080
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2703 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2762
Query: 8081 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2763 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2822
Query: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2823 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2878
Query: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSDV 8256
V E DLS ++ +A S EG + KD
Sbjct: 2879 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKD------------ 2921
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQIQQTENIIRSKTP 8313
+ + E +V+ ++A A Q +Q+ + D++ + Q + I +K
Sbjct: 2922 -VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD 2972
Query: 8314 TGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR 8372
L +K + K L S + ++ E+ L + + S + L +T
Sbjct: 2973 VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----N 3027
Query: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
W+ Q +E ++K++L+K ++ + ++W W+ + LE+ ++ D E
Sbjct: 3028 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGEN 3084
Query: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 8492
I KLK LQK +D ++ +N + + + D + + D V L
Sbjct: 3085 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 3144
Query: 8493 WRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
+ L++ + + F E+S L E +D + SN +LQ K L
Sbjct: 3145 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3204
Query: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8608
+KH++ L QD+ + +++GT + +V I L ++V L
Sbjct: 3205 ALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFL 3258
Query: 8609 E-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 8649
E KL + Q + S DELD+ V GR QK
Sbjct: 3259 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3301
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 373 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 431
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4778 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4826
Query: 432 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 485
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4827 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4870
Query: 486 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 531
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930
Query: 532 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 591
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4931 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4985
Query: 592 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 645
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045
Query: 646 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 698
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 5046 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105
Query: 699 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 753
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 5106 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5165
Query: 754 QD----LEDIEQRVPVMDAQYKIITKT 776
+ +E++ ++ P +D +TKT
Sbjct: 5166 AEHQTFMEEMTRKQPDVDK----VTKT 5188
Score = 33.5 bits (75), Expect = 9.5
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 382 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 433
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4871 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930
Query: 434 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 490
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4931 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4989
Query: 491 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 542
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4990 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 5049
Query: 543 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 598
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 5050 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 5093
Query: 599 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 658
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 5094 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 5136
Query: 659 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 718
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 5137 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5187
Query: 719 EY 720
Y
Sbjct: 5188 TY 5189
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 336 bits (861), Expect = 7e-91
Identities = 707/4022 (17%), Positives = 1549/4022 (38%), Gaps = 508/4022 (12%)
Query: 1235 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1292
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1341
Query: 1293 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1349
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1342 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1400
Query: 1350 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1405
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1401 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1458
Query: 1406 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1460
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1459 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512
Query: 1461 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1513
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
Query: 1514 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1573
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1573 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1629
Query: 1574 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1633
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1630 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1671
Query: 1634 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1680
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1672 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1727
Query: 1681 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1720
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1728 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1787
Query: 1721 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1780
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1788 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1845
Query: 1781 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1835
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1846 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1905
Query: 1836 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1883
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1906 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1962
Query: 1884 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1937
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 1963 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 2021
Query: 1938 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1995
A+ L S + + T D + G E + + + + + QD +
Sbjct: 2022 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 2081
Query: 1996 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 2082 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 2141
Query: 2056 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 2142 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 2201
Query: 2115 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2169
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 2202 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 2247
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2223
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 2248 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 2301
Query: 2224 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2276
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 2302 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2360
Query: 2277 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2335
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2361 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2402
Query: 2336 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2395
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2403 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2461
Query: 2396 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2455
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2462 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2495
Query: 2456 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2515
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2496 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2532
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2533 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2590
Query: 2576 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2631
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2591 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2650
Query: 2632 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2689
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2651 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2710
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2711 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2769
Query: 2750 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2800
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2770 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2820
Query: 2801 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2857
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2821 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2879
Query: 2858 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2917
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2880 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2921
Query: 2918 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2977
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2922 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2979
Query: 2978 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3037
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 2980 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 3039
Query: 3038 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3078
+DL + G + +E++ L Q + C E LQ +
Sbjct: 3040 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 3099
Query: 3079 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3138
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 3100 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 3159
Query: 3139 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3198
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 3160 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 3213
Query: 3199 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3253
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 3214 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 3267
Query: 3254 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3308
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 3268 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3327
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3368
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3328 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3387
Query: 3369 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3428
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3388 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3447
Query: 3429 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3482
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3448 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3507
Query: 3483 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3539
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3508 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3567
Query: 3540 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3597
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3568 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3625
Query: 3598 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYR-DEVEEVGARAQEILDESHV 3656
+ R + +++ WL E + E + +E + R +E+ E+
Sbjct: 3626 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3685
Query: 3657 NSRMGCQATQLTS-----------------------RYQALLLQVLEQIKFLEEEIQSLE 3693
N + +++S RY+ + + ++++ ++ I +
Sbjct: 3686 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3745
Query: 3694 ESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3750
+ + + + W T K + + + D+ + +K T+E+L + ++
Sbjct: 3746 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKDIID 3800
Query: 3751 SAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKC 3810
+ G + + E E + ++K++ ++ + + ++ LE+ L +F +
Sbjct: 3801 DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3860
Query: 3811 KALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE 3870
+ L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G LLE
Sbjct: 3861 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3920
Query: 3871 LV-------------------------------------QDVTLKDKIDQLQSDYQDLC- 3892
L Q DKIDQ+ + +
Sbjct: 3921 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 3980
Query: 3893 -------------------SIGKAMMEEIAGFEDRLNNLQMKGDTLIGQC--------AD 3925
S K + ++ + L+ +G+ +I + A
Sbjct: 3981 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 4040
Query: 3926 HLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA 3979
+Q KL Q N+H ++ + + A++ + H+S T++ Q
Sbjct: 4041 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIKDTQD 4093
Query: 3980 WLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLSNASV 4033
++ ++ P ++PS + AE I++ LQE+ ++L L + C + V
Sbjct: 4094 FIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPDKPIV 4151
Query: 4034 KTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH 4089
K + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 4152 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 4211
Query: 4090 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHLNDQ- 4146
++LE + + ++K F + +Q + + + L KK EES +H + L +
Sbjct: 4212 TDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 4269
Query: 4147 --WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHL 4204
W L + N + E L + ++ + +L + A+ +
Sbjct: 4270 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4329
Query: 4205 EALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK 4262
E K L + + +E + +IE ++ ++ + L QRW + + +
Sbjct: 4330 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4389
Query: 4263 RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4322
++ Q L + ++L +W + + ++ + P+ A+ L H+ +C+
Sbjct: 4390 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAA 4449
Query: 4323 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4382
EAK+ KSL++ +++A + I + +++ + + + +R+ L +AL+
Sbjct: 4450 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4509
Query: 4383 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4442
+F ++ + + Q E+ + L+ D V Q+ K + +++ ++ L
Sbjct: 4510 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIEL 4569
Query: 4443 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4502
G L +Q+ + L +QS ++ V+Q+ R + L+ K F E + K
Sbjct: 4570 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4629
Query: 4503 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4562
WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4630 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4689
Query: 4563 NEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L +E
Sbjct: 4690 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749
Query: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTGQPWQ 4677
Q V D ++ ++L D +A E+ +V L + EG R W
Sbjct: 4750 QLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WV 4806
Query: 4678 PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEET 4737
+M L T + + + + + LE +E + L L + EQ+
Sbjct: 4807 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLRFHGV 4864
Query: 4738 LPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792
LP +E + + L++ L + T + + P + +H I +
Sbjct: 4865 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4924
Query: 4793 ELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE 4852
+ + + + S + I Q + L WL+ + L+ D + + I +E
Sbjct: 4925 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEVIPQE 4979
Query: 4853 IRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRT 4912
I +++ E Q+ + M + +K TK + +AD + + LD R
Sbjct: 4980 IEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRF 5038
Query: 4913 RQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLAGNGL 4952
++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 5039 PASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDF 5098
Query: 4953 DV 4954
D+
Sbjct: 5099 DI 5100
Score = 322 bits (825), Expect = 1e-86
Identities = 858/4699 (18%), Positives = 1838/4699 (39%), Gaps = 637/4699 (13%)
Query: 3186 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3243
E++ + +QD L+ ++M + + DLP+ + ++V I +E L K
Sbjct: 602 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 661
Query: 3244 AQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWM 3303
Q+ ++ ++ +L SQY L N ++ + LD + HN S EL W+
Sbjct: 662 EIQMTA--PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELI-WL 715
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
+ +Y + ++ + E + + Q++E +K + E +L P +
Sbjct: 716 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE-NIKSVQEIAEQLLLENHPARL 774
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEA-----N 3418
TI+ +++ W+ +L C+ +E + + T+Y F + D+ EA N
Sbjct: 775 -TIEAYRAAMQTQWSWILQL---CQC-VEQHIKENTAY------FEFFNDAKEATDYLRN 823
Query: 3419 LNESERQHAELRDKTTMLGKAKLL-------NEEVLSYSSLLET--------IEVKGAGM 3463
L ++ ++ D+++ + K + L EE+L Y S + I++K
Sbjct: 824 LKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 882
Query: 3464 TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQE----- 3518
T + ++ + + YR I+ + K ++ V + ++ K G E
Sbjct: 883 DCPLKTSIPIKAICD-YRQIEI----TIYKDDECVLANNSHRAKWKVISP-TGNEAMVPS 936
Query: 3519 ---------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPS 3569
+E +D + +E T + L+N + R + S
Sbjct: 937 VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVAS 996
Query: 3570 ---GIPQAEDRALESLRQDWQAYQHRLSETR-------TQFNNVVNKLRLMEQKFQQVDE 3619
+P + L +L+ ++ + E++ TQ VN + Q E
Sbjct: 997 IKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK------QYYQE 1050
Query: 3620 WLKTAEEKKWHEEV-TAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQV 3678
LK+AE ++ E V Y EV + R + D R + L + ++
Sbjct: 1051 LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHES----VFRI 1106
Query: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGK-------- 3730
EQ K L++E++ L++ ++++ + + S +V T +++ V+
Sbjct: 1107 TEQEK-LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 1165
Query: 3731 ----KLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3786
KLKT+ ++LK+ + +L+K K L E EA K ++ L
Sbjct: 1166 TYIDKLKTVNLVLKNTQAAEALVKLYETK-------LCEEEAVIADKN------NIENLI 1212
Query: 3787 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK-YK 3845
ST++ QW +E E V + EL + KA + +K
Sbjct: 1213 STLK------------------------QWRSEVDEKRQVFHALEDELQKAKAISDEMFK 1248
Query: 3846 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGF 3905
+ ++ L + +EK + L+E Q+V + Q+ + +DL IGK++ +
Sbjct: 1249 TYKERDLDFDWH----KEKADQLVERWQNVHV-----QIDNRLRDLEGIGKSLKY----Y 1295
Query: 3906 EDRLNNLQMKGDTLIGQCADHLQAKLKQNV--HAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
D + L D I Q + Q K+++N ++ T+ + + + M QS E
Sbjct: 1296 RDTYHPL----DDWIQQ-VETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1350
Query: 3964 LQKHVSRQD-TLQQCQAWLSAVQPDLEPSPQPPLSR----AEAIKQVKHFRALQEQARTY 4018
QK+ + T++ + + ++ + P+ R + A ++ F L+ +
Sbjct: 1351 CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL 1410
Query: 4019 LDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA 4078
+ L+ + S+K ++ + E+ ++ + +A+ L Q W S + L+DA
Sbjct: 1411 VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-QKWV------SNISKTLKDA 1463
Query: 4079 DQQLQN--MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE 4136
++ + K++ S E++ + +S+ ++ +K +K+T +E +
Sbjct: 1464 EKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG---------DKMTDEERNEL 1514
Query: 4137 HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV----EVFLEKFTTEWDNL 4192
K++ L + + L +S L++ ++ Q + D +V + + EK D L
Sbjct: 1515 EKQVKTLQESYNLLFSES----LKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1570
Query: 4193 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4252
+++ H EA ++ +KY + +++ QK ++ E+VK + L++
Sbjct: 1571 TQTENRLIG-HQEAFMIGDGTVELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKE 1627
Query: 4253 RWFQLED----LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4308
+L LI++K+ + E+LN+ + ++ E + A+K+
Sbjct: 1628 NGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK------ELDKVVTTAIKEET---- 1677
Query: 4309 AQNLLMDHLAICSELEAKQMLLKSLI---KDADRVMADLGLNERQVIQKALSDAQSHVNC 4365
+ +A +LE + +++L+ + D+ G +QVI++ + Q
Sbjct: 1678 ------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG- 1730
Query: 4366 LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4425
+G+ + L + Q + Q +K+ ++ K
Sbjct: 1731 -KSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKVK------------AQHEKII 1775
Query: 4426 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL------QKC 4479
QA + Q+ L QG+ L E EK ++ ++EL+ Y++ L K
Sbjct: 1776 SQHQAVIIATQSAQVLLEKQGQYLSPE----EKEKLQKNMKELKVHYETALAESEKKMKL 1831
Query: 4480 SHRLQE-LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE----LHTQLAKY 4534
+H LQE LEK F D+ + HWL+Q++ E+ + ++ L T+L +
Sbjct: 1832 THSLQEELEK-------FDADYTEFEHWLQQSE----QELENLEAGADDINGLMTKLKRQ 1880
Query: 4535 QNILEQSPEYENLLLTLQRTGQTILPSLN--------EVD----HSYLSEKLNALPRQFN 4582
++ E ++ L + +G +L + +VD H + KL+ +F
Sbjct: 1881 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR 1940
Query: 4583 VIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ 4642
+ + +++ + +Y + + L+ L+A SK ++ + +LQ
Sbjct: 1941 SLYSKCNVLGNNLKDLV---DKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1997
Query: 4643 ---DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK------MLHLVTLYHRLKR 4693
+ +A+ +++ AV++L + E P K + +V Y L +
Sbjct: 1998 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2057
Query: 4694 QTEQRVSLLEDTT----SAYQEHEKMCQQLERQLKSVKEE-QSKVNEETLP--AEEKLKM 4746
+R L+ T S ++M + S+KE+ Q +N L + + +
Sbjct: 2058 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 2117
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+AG + ++V +E DP + +++ + ET+
Sbjct: 2118 EQDIAGRQSSINAMNEKVKKFMETT----DPSTASSLQAKMKDLSARFSEASHKHKETLA 2173
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
+ E + ++ +S L K + V D+ +D+ E + +Q E
Sbjct: 2174 KMEE-LKTKVELFENLSEKLQTFLETKTQALTEV--DVPGKDVTELSQYMQESTSEFLEH 2230
Query: 4867 LRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQR 4926
+ + L KE + A + LS+ ++++ ++ ++ +T Q
Sbjct: 2231 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2290
Query: 4927 YYQVFQAANDWLEDAQE---LLQLAGNGLDVESAEENLKSHMEFFSTE----DQFHSNLE 4979
+ + ++ W+++ + ++Q + D+ + E+ K E +S + + +++
Sbjct: 2291 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2350
Query: 4980 ELHSLVATLDPLIKP-----------------TGKEDLEQKVASLELRSQRMSRDSGAQ- 5021
L +L++ + K T E+ ++ G +
Sbjct: 2351 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYED 2410
Query: 5022 -----VDLLQRCTAQWHDYQKAREE---VIELMNDTEKKLSEFSLLKTSSSHEA-EEKLS 5072
D + + QKA+EE +++ + K +++ + EA + ++
Sbjct: 2411 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2470
Query: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTT-VWQRWTRLRAVAQDQ 5131
++K+ + + K+ L++K ++L + D +A + M T + +W L + D+
Sbjct: 2471 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2530
Query: 5132 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV---- 5187
++ LE++ + T F ++ +L EK +L L +
Sbjct: 2531 QQKLEESSNNLTQFQT-----------VEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2579
Query: 5188 --LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLM----QEITAMQDRCLNMQEKVK 5241
+++ Q+ A + + L+ G PGE+P L +++ A+ + ++ ++
Sbjct: 2580 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2639
Query: 5242 TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI------EIDAQLEELQILLTE 5295
+ Q + ++ + S+ + + L + ++ QLE Q + E
Sbjct: 2640 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2699
Query: 5296 ATNHRQNI-------EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIK 5347
++ I E ++ KE+YL +ELS QL + K + + ++ ++
Sbjct: 2700 IQQEKKQIKVAQALCEDLSALVKEEYL------KAELSRQLEGILKSFKDVEQKAENHVQ 2753
Query: 5348 EVEQSKATS---QELSRQIQK---LAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5401
++ + A+S Q++SR Q K+ + AK D + D K + L
Sbjct: 2754 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA- 2812
Query: 5402 NSKLMELDAAVQK--FLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5459
S + E A + L+ G L ++ + +Q + R +KL ++
Sbjct: 2813 QSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2872
Query: 5460 EYNEMLELILKWIEKAK----------VLAHGTIAWNSASQLREQYILHQTLLEESKEID 5509
+Y E +E + WI+K + A G + L+++ H ++E
Sbjct: 2873 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA 2932
Query: 5510 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5569
+ L ++ E + T++ + ++ TE+L K L+N+ K+ ++ E
Sbjct: 2933 NSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KFCLENMTQKFKEFQEVSKE 2987
Query: 5570 LKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ-AVQLCQSALRI 5627
K+ LQ A EQ + + + L+ Q +++LK +V A +L Q +
Sbjct: 2988 SKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVE 3045
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
D + + + +E S L ++C+ ++ + ++ ++ +
Sbjct: 3046 ASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD 3105
Query: 5688 REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5747
E++ + + LQ Q + +K++ + N CKM+ + + L+ +
Sbjct: 3106 DELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGI 3165
Query: 5748 -TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE-----ESGEEGTNSE 5801
++E L++ +LL A V T R S + E + EE S+
Sbjct: 3166 KRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 3221
Query: 5802 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5861
PV ++NQ + ++ E ++ K Q + + +
Sbjct: 3222 ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 3271
Query: 5862 ATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS-ISTKMEAIELKLS 5916
+T L D+ W+TL ++++ L EAL ++QD+L+S +S ++ EL +
Sbjct: 3272 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3331
Query: 5917 ESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE-----ADPAEQLA 5971
+ P P ++ +A + E +LQ +++ +S++ E++ E A+PA+++
Sbjct: 3332 QKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVIKREGEKIATTAEPADKVK 3384
Query: 5972 LQSTLTVLAERMSTIRMKASGKRQLLE-------------EKLNDQLE--EQR------- 6009
+ L++L R + KA + + LE E LN+ L E+R
Sbjct: 3385 ILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPI 3444
Query: 6010 --QEQALQRYRCEADELDSWLLSTKATLDTALS--------PPKEPMDMEAQLMD-CQNM 6058
Q L+ + L+ +++ L A+S +E DM +D Q
Sbjct: 3445 GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW 3504
Query: 6059 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QLAGKLRRL----------- 6101
+EI++K + SEL + L K +DE E ++ KL +L
Sbjct: 3505 YIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3561
Query: 6102 --KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6159
+ L LQ + ++ N+ E T + +Q+ L + + + S
Sbjct: 3562 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3621
Query: 6160 LQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG-MEGEKS 6218
K LEQ L L R + S EE+ E ++LS E ++GE++
Sbjct: 3622 TDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV--------ELLSYETQVLKGEEA 3669
Query: 6219 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S Q +M+ + L +E + LL + L + +L P R G+ + +D
Sbjct: 3670 S---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWRAREGLE----KMVAEDNE 3721
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 6338
+ D + Q EE+ + +I Q+ A +W+ + E++L +
Sbjct: 3722 RYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3773
Query: 6339 EETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
E+ +T F EIL K++ +++ K+ + A E + + ++ L +L
Sbjct: 3774 EQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTACSE--EEKQSMKKKLDKVL 3829
Query: 6392 GRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADNKYIILQKLANVFE-QPVA 6449
+ + ++R Q+ ER Q ++N F + L+ L + + II Q A E + +
Sbjct: 3830 KNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3888
Query: 6450 EQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQELSKLQD-MYDELMMIIG 6504
+Q E +Q + + E I ++ + G +L P S+QE D +Y ++ +
Sbjct: 3889 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 3948
Query: 6505 SRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQ 6564
R L++ ++ +Q+ + + + LE E++ I + E+I++ + ++K
Sbjct: 3949 KRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSV 4007
Query: 6565 GLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVE--LEYILETWSH 6622
+E L ETL Q E++A++ K + V+ L+ ++ W +
Sbjct: 4008 DMEKLQPLYETL------------KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 4055
Query: 6623 L----DEDQQELSRQLEVVE-------SSIPSV----GLVEENEDRLIDRITLYQH---- 6663
+ +E + +L +E+ E S I ++ + + ED ID + Q
Sbjct: 4056 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 4115
Query: 6664 --LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHR 6718
++ ++ Q +L V++ G L+ + D ++ +++L W S + +
Sbjct: 4116 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 4175
Query: 6719 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV 6778
LE ++ +YQ + W+ A +L + + +LE V+ + +F E
Sbjct: 4176 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTDLETVKQQIEELKQFKSEA 4231
Query: 6779 DAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 6834
Q ++ L+ +LL LKKV D T++ L + W L I Q KL
Sbjct: 4232 -YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 4289
Query: 6835 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCK 6892
+ +HA+ E+++W++ E ++ + + +G KAI L K+ + D+
Sbjct: 4290 LLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKAIEIELAKHHVLQNDVLAH 4344
Query: 6893 QLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q TV+ VN++ + +ES ++ ++ +L +N+ WQ + ++ Q L+G L
Sbjct: 4345 QSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ ++ L+ W E+ L +G + + L ++ +AKE+ + +
Sbjct: 4401 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4460
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
Q G ++ + + + + L + W +++ + + K L+ L+ +
Sbjct: 4461 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4520
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++L +A +L+ + L+ V Q+D + +++ + + L
Sbjct: 4521 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4580
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKALLQLWQRYKDYSKQCAST 7183
+ N L V RW +++ + E+ +S +K + W + ++ ++ +
Sbjct: 4581 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4640
Query: 7184 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
+ + + N+ D++ T + + K LG + G LK++
Sbjct: 4641 LDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK- 4688
Query: 7244 DASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQAGVLDYETFAKSLEALEAW 7296
+++ D L L L L +C ++Q L+ +L F +L+AL W
Sbjct: 4689 -----TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDW 4743
Query: 7297 IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7356
+ E L P H D+ + ++ K + + L L ++
Sbjct: 4744 LYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4802
Query: 7357 K-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7411
+MQ L+ W + + + + ++L++ L Q + F +E+L + EQ L
Sbjct: 4803 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4862
Query: 7412 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLL 7469
+ + L H+ F ++ ++ L+ G +L D +T++
Sbjct: 4863 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4922
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-EVSYLPMSGLGSVPIPLQQ 7528
+++ V+ A+Q + + S + +E+ E L WL + L +P +++
Sbjct: 4923 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 4982
Query: 7529 ARTLFDEVQ-FKEKVFLRQ 7546
+ L E Q F E++ +Q
Sbjct: 4983 VKALIAEHQTFMEEMTRKQ 5001
Score = 312 bits (799), Expect = 1e-83
Identities = 770/4311 (17%), Positives = 1668/4311 (38%), Gaps = 501/4311 (11%)
Query: 1482 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1535
S S + ++ V Q + L S E+E + +++ + R++ + + Q
Sbjct: 1030 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 1089
Query: 1536 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1594
IR E H T L ++ ++ +++L I EF + A + + +E
Sbjct: 1090 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 1149
Query: 1595 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1654
VLQ + S+SS + V+ Q A AL + YE L
Sbjct: 1150 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 1198
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
E ++A +E +S+ W R +V+ + Q+ AL++E+
Sbjct: 1199 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 1236
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
K + + +F + D+ K +QL ERW+++ I+ R+ L+ +
Sbjct: 1237 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1290
Query: 1773 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1824
+ + + WI+ +++TT I ++Q L + K +E+E K+
Sbjct: 1291 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1345
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1881
++ Q + + + + +L + +A + + V+RR++ S + EF+
Sbjct: 1346 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1401
Query: 1882 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1938
+ ++ + Q ++ A +S+ + E + +E++ + ++ AK L+ ++ L
Sbjct: 1402 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1461
Query: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1998
A+ K S+Q+ S ++++ + E++ L T Q L + K
Sbjct: 1462 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1503
Query: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2057
++ TD+ER N+LE ++ + + L + KQ+ +
Sbjct: 1504 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1541
Query: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
+ +V+ +I E + + G+ DL+ + +N +++ + + ++
Sbjct: 1542 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1586
Query: 2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2176
T+ +LK SK E + M + L ++ L E +K+ D +L++
Sbjct: 1587 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1642
Query: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2236
+ K ++ K E++ L D V++T + E V Q+ E+ + ++N
Sbjct: 1643 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1695
Query: 2237 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2296
L ++ S V + R H +V + F E D +
Sbjct: 1696 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1738
Query: 2297 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2356
E+ T D +TQ ++ + KV+ AQ+E K +
Sbjct: 1739 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1775
Query: 2357 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2410
Q+ I +TQ L + E E L + M L +E A S+ K SL
Sbjct: 1776 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1835
Query: 2411 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470
QE LEK F EF+ W ++ + D L KL ++ + V + L
Sbjct: 1836 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1894
Query: 2471 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2518
+T G + ++ +S +Q ++ A + F++ +C L+
Sbjct: 1895 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1954
Query: 2519 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2577
D + +ED L + E + ++L E P+ + ++ + + G++ +
Sbjct: 1955 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 2013
Query: 2578 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
+ +++KL + + LL G + ++ +++L + E+ Q+ L
Sbjct: 2014 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 2073
Query: 2634 EALEEALQSMWFWVKAIQDRLA----CAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN 2689
++++ L M W+ ++ L ++ +D + K + QDI + +N
Sbjct: 2074 LSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI----AGRQSSIN 2129
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
K ++ + +++ +Q +++ L +++ + +E + ++ +
Sbjct: 2130 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2189
Query: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--- 2806
+L+ ++E+ Q + P + E + S E + H LH L+ +
Sbjct: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL 2249
Query: 2807 ------LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD------ 2854
+ EKT + S K E+ + + +T +E++ + +VK ++
Sbjct: 2250 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 2309
Query: 2855 -------AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRV 2907
+ L K+ +WS + + + LI + A ++ V
Sbjct: 2310 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2369
Query: 2908 ESLAPEVKQNTTASGCELMHTE--MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965
+S + TA+ E + +++ D L++ ++ E
Sbjct: 2370 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA-------EL 2422
Query: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGK------NTDEEIVECWHKGQEILDA-LQK 3018
+ ++++L++A E+ SA+++ W Q++ K TD E V+ + + +A L++
Sbjct: 2423 NTKLSKLQKAQEESSAMMQ-WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2481
Query: 3019 AEPRTEDLKSQLNELCRFSRDL------STYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
+ ++LK +L EL + D ++ +E N L + + + L
Sbjct: 2482 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2541
Query: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132
Q F+ +QWLV ++ + + + + ++T Q++Q L E + + +
Sbjct: 2542 TQ-FQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2600
Query: 3133 SKGE-LLSTLLTKEKAKGI-QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAE 3190
+ G+ +LS +GI + ++ A + W + L + ++ ++ ++
Sbjct: 2601 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2660
Query: 3191 PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEG 3250
+ D LS + + S A ++ + Q + +EI + Q+ + AQ L E
Sbjct: 2661 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI----KVAQALCED 2716
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKE-------KVSRLDRIVAEHNQFSLGIKELQDWM 3303
+A + ++LS Q + K+ V L A +QF ++ Q W+
Sbjct: 2717 LSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL 2776
Query: 3304 TDAIHMLDSYCHPTSDK-SVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362
D + HP S K VL+S + + + + GE++L T
Sbjct: 2777 -DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE 2835
Query: 3363 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE- 3421
+Q QL ++K W + +++L+ +L K Y++ V W+D + NL E
Sbjct: 2836 KAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI 2895
Query: 3422 --------SERQHAELR----DKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
E A+L+ + G +LLN +SLL E+ +T+
Sbjct: 2896 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA---NSLLSVCEIDKEVVTD---- 2948
Query: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529
E + L ++ + E+ E + + +E+Q K + L +E+LD + L
Sbjct: 2949 --ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 3006
Query: 3530 GDAHTHE-TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRAL--ESLRQDW 3586
A++++ T+ Q+ + + Q L L V S D L E++ Q+
Sbjct: 3007 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 3066
Query: 3587 QAYQHRLSE------TRTQ-FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDE 3639
++ E T+ Q + N +R M +F + D+ L + E + E
Sbjct: 3067 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 3126
Query: 3640 VEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL------- 3692
+ + E L S+ N+ C+ T L+ + ++ L ++ L
Sbjct: 3127 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 3186
Query: 3693 -EESESSLSSYSDWYGSTHKNFKNVATKIDK---------VDTVMMGKKLKTLEVLLKD- 3741
E+ E ++ ++Y S K F + K ++ ++T + ++L +V K+
Sbjct: 3187 EEQVEGTIKRLEEFY-SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3245
Query: 3742 MEKGHSLLKSAREKGERAVKYLEEGEAER-LRKEIHDHMEQLKELTSTVRKEHMTLEKGL 3800
+E + G+ ++ + + + L ++ D + K L V + L++ L
Sbjct: 3246 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3305
Query: 3801 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3860
F D ++L W+ + +E++ + P E KAQ+ + K LQ+ + + +V+
Sbjct: 3306 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3365
Query: 3861 VREKGEALL---ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
++ +GE + E V + ++ L S ++ L + KA N Q++G
Sbjct: 3366 IKREGEKIATTAEPADKVKILKQLSLLDSRWEAL--LNKA----------ETRNRQLEGI 3413
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977
+++ Q L + + T + C LE ++ +H + +D +
Sbjct: 3414 SVVAQQFHETLEPLNEWLT-----TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3468
Query: 3978 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037
L +S +++K + +R D++ S D S
Sbjct: 3469 NKHLHQA-----------VSIGQSLKVLS--------SREDKDMVQSKLDFSQVWYIEIQ 3509
Query: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELEL 4094
+ + ++Q L A+ + E+ + +E+ L D + + ++ SEL
Sbjct: 3510 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR- 3568
Query: 4095 NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS 4154
V Q ++K QA +N + E + + T E ++ + ++ D+ + S
Sbjct: 3569 ------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3621
Query: 4155 NNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4209
++ E+ LQ R H C + +V +E + E L +A + + LKK
Sbjct: 3622 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3681
Query: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VS 4268
A + K ++ L + ++E + +E +++ + +R+ + D I +K++ +
Sbjct: 3682 EA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3738
Query: 4269 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328
L Q+ EL W E + + D L E+ +
Sbjct: 3739 AAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKD 3797
Query: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388
++ L+K ++M E+Q ++K L + + + + +R L +A S QF
Sbjct: 3798 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3857
Query: 4389 MAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4448
+ + + + I L + + +Q + + + + ++ + + G +
Sbjct: 3858 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3917
Query: 4449 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4508
L+ E++ E + K ++Y + + R L++ + F + D+ L+
Sbjct: 3918 LL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 3976
Query: 4509 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHS 4568
+ ++ E ++ Q+++ +N+ + + L TL++ G+ ++ D
Sbjct: 3977 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 4036
Query: 4569 Y----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQF 4623
+ +KL+ + + I L +++ K+ + + LA K + + L ++ + + F
Sbjct: 4037 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DF 4094
Query: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP---D 4679
+R + P + Q+ I +E+ GL E +D +N E + G+P +P
Sbjct: 4095 IRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 4153
Query: 4680 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE---- 4735
+ L + + L + + R+ LE+ A +++ Q + + + + ++
Sbjct: 4154 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD 4213
Query: 4736 -ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGE 4793
ET+ + E+LK + S A Q I ++R+ E L L + E +H +Q E
Sbjct: 4214 LETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLME 4267
Query: 4794 LKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4849
LKL+ ++ E + + ++ ++ FQ + L WL + LS + + + I
Sbjct: 4268 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
Query: 4850 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4909
+ E+ K + Q +V + + A++ + + +++L++ L L++ ++ E
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4387
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME- 4966
R+ L Q + ++ + WL D + L LA L E+A+E L HME
Sbjct: 4388 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHMEV 4446
Query: 4967 ---FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5023
F + E+ + S +++ ++A + + +++Q + +L+ + + + +
Sbjct: 4447 CAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERKT 4502
Query: 5024 LLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVSV 5080
L+ ++ + ++ I + E+ L S SL+ + + + EHK +
Sbjct: 4503 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFANE 4558
Query: 5081 VNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140
VNS E+I+ L++ + L+ + + +V RW ++ ++ + L+DA
Sbjct: 4559 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4618
Query: 5141 EWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGML 5200
F+ K E +++ + L ++ T L H F L + S
Sbjct: 4619 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4678
Query: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV-- 5257
+ S+ E+ L + + D +++K T GK V+++ K E +
Sbjct: 4679 NRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLF 4729
Query: 5258 ----ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQKE 5312
+ ++ W+ Y P + D + ++ +++ NH+ +
Sbjct: 4730 SGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AFQ 4775
Query: 5313 KYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTT 5372
K LG T S+Q AL R+ I+ + K QELS + + + +
Sbjct: 4776 KELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSIS 4826
Query: 5373 ILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGK 5432
T+L+A EE L+E A ++ L +G L +
Sbjct: 4827 KQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRT 4874
Query: 5433 LTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWNS 5487
L + H++ +++ E + ++LN+A + + + + + I WI + +AW
Sbjct: 4875 LIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAK 4934
Query: 5488 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQ 5547
Q R L + ++ LEA+ LQ+ + T+K + + + E EE++
Sbjct: 4935 QHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVKA 4985
Query: 5548 MI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
+I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 4986 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 5036
Score = 298 bits (764), Expect = 1e-79
Identities = 722/4020 (17%), Positives = 1553/4020 (38%), Gaps = 449/4020 (11%)
Query: 4877 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 1108 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 1167
Query: 4928 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 4972
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 1168 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 1227
Query: 4973 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5026
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 1228 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 1287
Query: 5027 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 1288 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1344
Query: 5085 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5142
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1345 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1404
Query: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5202
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1405 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1457
Query: 5203 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5256
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517
Query: 5257 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5316
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1565
Query: 5317 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5359
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1566 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1625
Query: 5360 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5414
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1626 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1685
Query: 5415 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5468
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1686 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1744
Query: 5469 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5525
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1745 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1801
Query: 5526 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1802 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1861
Query: 5586 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5634
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1862 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1921
Query: 5635 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5690
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1922 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1970
Query: 5691 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5748
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 1971 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 2018
Query: 5749 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5796
+++ AE D G LLP + + GR L V E S ++
Sbjct: 2019 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2078
Query: 5797 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5848
G N E S + P ++++I Q ++ + +A ++
Sbjct: 2079 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 2136
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 2137 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 2196
Query: 5909 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 5968
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 2197 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 2255
Query: 5969 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6018
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 2256 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 2315
Query: 6019 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
A++L L TK + E + + N++ + A++ +V +
Sbjct: 2316 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2373
Query: 6079 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6135
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2374 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2433
Query: 6136 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6184
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2434 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2493
Query: 6185 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6228
E+L E + D E P D QEL + E+SS
Sbjct: 2494 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2547
Query: 6229 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6266
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2548 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2607
Query: 6267 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6323
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2608 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2666
Query: 6324 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6383
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2667 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2722
Query: 6384 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2723 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2780
Query: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6487
P++ +++ ++ K+F + +K E ++
Sbjct: 2781 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2840
Query: 6488 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6546
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2841 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
Query: 6547 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6602
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2960
Query: 6603 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6659
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 2961 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 3016
Query: 6660 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6715
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 3017 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076
Query: 6716 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6775
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 3132
Query: 6776 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6833
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 3133 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3192
Query: 6834 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6889
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 3193 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 3249
Query: 6890 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 6949
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 3250 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 3304
Query: 6950 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7008
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
Query: 7009 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7068
I++ G + + ++ L L W L + L+ +
Sbjct: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3424
Query: 7069 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7128
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3483
Query: 7129 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7174
+ + + + + W EI E+ S LLQ +
Sbjct: 3484 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3540
Query: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7229
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3541 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3600
Query: 7230 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7283
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3659
Query: 7284 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7343
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3660 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3694
Query: 7344 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7397
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3695 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3754
Query: 7398 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7455
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3755 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3814
Query: 7456 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3815 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3873
Query: 7516 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7573
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3874 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3924
Query: 7574 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7630
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3925 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3983
Query: 7631 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7679
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 3984 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 4042
Query: 7680 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7739
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 4043 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 4102
Query: 7740 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 4103 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 4162
Query: 7796 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7853
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 4163 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 4219
Query: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 4220 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 4276
Query: 7914 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
+ R+ K+E +F WL +E + G + EL K
Sbjct: 4277 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4336
Query: 7974 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8033
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4337 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4396
Query: 8034 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8093
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4397 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4455
Query: 8094 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8150
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4456 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4496
Query: 8151 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8209
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4497 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4544
Query: 8210 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 8269
+ + D + ++ S + + D+ G K F + V L ++ + K+
Sbjct: 4545 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4603
Query: 8270 ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELD------TSYK 8323
+ ++ A + +Q +A ++++E + S+ + D +K
Sbjct: 4604 QRLVERGRSLDDA-RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4662
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ +
Sbjct: 4663 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVER 4719
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8443
+ ++++ L QF L ++ WL E +L + Q + DI + I K QK
Sbjct: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKE 4777
Query: 8444 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8503
+ R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4778 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837
Query: 8504 CQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4838 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAEL 4893
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4894 NKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4953
Score = 295 bits (754), Expect = 2e-78
Identities = 767/4203 (18%), Positives = 1632/4203 (38%), Gaps = 605/4203 (14%)
Query: 4269 VTNLE-ELNVVQSRFQELMEWAEEQQPN-------IAEALKQSPPPDMAQNLLMDHLAIC 4320
+T LE E+NV + +QEL++ AE ++ I+E + ++ L+ +
Sbjct: 1034 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 1093
Query: 4321 SELEAKQMLL------KSLIKDADRVMADLGLN----ERQVIQKALSDA----QSHVNC- 4365
E + + + L K+ +R+ DLG E Q A S + +S +N
Sbjct: 1094 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 1153
Query: 4366 ---LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422
++ + Y++K L L A + ++ +E K+ E + +++ +
Sbjct: 1154 LQNMNQVYSMSSTYIDK-LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1212
Query: 4423 KTCKSAQASLK-------TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV--YD 4473
T K ++ + ++E+ A E+ K E++ K + Q V +
Sbjct: 1213 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 1272
Query: 4474 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFP-EINLMNESSELHTQLA 4532
+V + +RL++LE S K++++ + W++Q + + N S L TQL
Sbjct: 1273 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1332
Query: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVA--LAKD 4590
+ + ++ + ++ + Q+ + ++ + + ++ + +Q + + +
Sbjct: 1333 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1392
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILD 4650
+QE + R Y +L+ L TQ + R+ EE SL++ + ++
Sbjct: 1393 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE--------EEEKSLEEEKKEHVE 1444
Query: 4651 EVAGLGEAVDELNQKKEGFRSTGQP----------------WQPDKMLHLVTLY---HRL 4691
+ L + V +++ + G+P Q + L + L+ H
Sbjct: 1445 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1504
Query: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
K E+R L + + + + + + +QL+ + EE + AE + + L
Sbjct: 1505 KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQ 1564
Query: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
G R+ H E + +K + + + Q +++ A+ E V E+
Sbjct: 1565 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF 1624
Query: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL-RIM 4870
+ ++ + ++ ++L ++ L + + + ++ + E+ + L +++
Sbjct: 1625 LKENGEKLSQEDKAL---------------IEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1669
Query: 4871 NALSHKEKEKFTKAKELISAD--LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYY 4928
+E EK K+L + +E+ L LS +D D + A + ++ Q ++
Sbjct: 1670 TTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHK----QVIEQNGTHF 1725
Query: 4929 QVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKS--------HMEFFSTEDQFHSNL 4978
Q + E+ + L +D V + +ENL H + S
Sbjct: 1726 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1785
Query: 4979 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5038
+ L+ + P KE L++ + L++ + +S ++ L + +
Sbjct: 1786 QSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1845
Query: 5039 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5098
E + +E++L + KL K SF E +++ + +
Sbjct: 1846 YTEFEHWLQQSEQELENLEA-GADDINGLMTKLKRQK-------SFSEDVISHKGDLRYI 1897
Query: 5099 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5158
+GN +A S S + T A ++ ++ L+ A D + +K +
Sbjct: 1898 TISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1955
Query: 5159 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5218
L DK Y D L Q+
Sbjct: 1956 LVDKYQ----------------HYEDASCGLLAGLQAC---------------------- 1977
Query: 5219 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5278
E TA + ++ E + + K ++++L++ + ++ QI+S + V++ K+
Sbjct: 1978 ------EATASK----HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK---TA 2024
Query: 5279 TIEIDAQ------LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LA 5330
+ +DA+ ++Q L + +++ K E+ EK L L LS+Q L
Sbjct: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK---LQITLTRSLSVQDGLD 2081
Query: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
E+ L ++ +KE Q S L I K N++
Sbjct: 2082 EM---LDWMGNVESSLKEQGQVPLNSTALQDIISK-----------------NIM----- 2116
Query: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNG-QLGKPLAKKIGKLTELHQQTIRQAENRLS 5449
L +++ G S + ++ V+KF+E L K+ L+ + + + L+
Sbjct: 2117 ---LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2173
Query: 5450 KLNQAASHLEEYNEMLELILKWIE-KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI 5508
K+ + + +E + + E + ++E K + L + ++L QY+ T E E
Sbjct: 2174 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL-SQYMQEST--SEFLEH 2230
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565
LE + L+ ++S + ++ L ++ +E+ IK + + + + +
Sbjct: 2231 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 2290
Query: 5566 FEAELKKLQAALEQA--QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ---- 5619
F+ +K L++ +++ + + P G L + L + L + P++Q V
Sbjct: 2291 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2350
Query: 5620 -LCQ--SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676
LC SA+ P +A++ A L + A+ + + + +
Sbjct: 2351 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG--LTSIKKDMTDISHGY 2408
Query: 5677 KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG----YQEQIASLNS--- 5729
+ L L++ E+ K S +Q+ Q + S + QK+ +Q+ A ++
Sbjct: 2409 EDLGLLLKDKIAELNTK---LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2465
Query: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA--GRCHTL-- 5785
K ++ K+ A + V +V+ L + +L E TP A M+T + L
Sbjct: 2466 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2525
Query: 5786 LSPVTEESGEEGTNSE--------------ISSPPACRSPSPVANTDASVNQDIAYYQAL 5831
L+ ++ EE +N+ + P++ +N Q L
Sbjct: 2526 LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2585
Query: 5832 SAERLQTDAAKIHPSTSASQEFYE-PGLEPSATA----KLGDLQRSWETLKNVISEKQRT 5886
E T + T+A Q PG +PS +L + + W++L +S++
Sbjct: 2586 LQE-FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2644
Query: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQ 5943
+ +A+ + +YQ L+S+S K+ ++ KLS S P++ Q+ Q + EI +
Sbjct: 2645 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2704
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
+I Q +L E+L + E +L+ Q L + + + KA Q L+
Sbjct: 2705 KQIKVAQ-ALCEDLSALVKEEYLKAELSRQ--LEGILKSFKDVEQKAENHVQHLQSACAS 2761
Query: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDM-----------EAQL 6052
+ Q+ + Q + E + A LD S K+ D E +
Sbjct: 2762 SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2821
Query: 6053 MDCQNMLVEIEQKVVALSELSVH---------------NENLL---LEGKAHTKDEAEQL 6094
+ +N+L++ + A +L ++ EN L LE K++ E L
Sbjct: 2822 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2881
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + + +L E++ L E E S L + Q Q +
Sbjct: 2882 WPWIDKCQNNLEEIKFCL---------DPAEGENSIAKLKSLQKEMDQHF---GMVELLN 2929
Query: 6155 QRQSSLQQQKELEQELA--EQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG 6212
+SL E+++E+ E KSL++ V E++ + E ++ +S+E
Sbjct: 2930 NTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-- 2987
Query: 6213 MEGEKSSAEDQMRMKWESLHQEFS--------TKQKLLQNVLEQ-------EQEQVLYSR 6257
+ + A++Q+ + Q +S T+QK LQ + Q Q+ V+ +
Sbjct: 2988 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEAS 3047
Query: 6258 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVS 6317
++ S V L + + Q+ S ++ +D +F E Q G H + + + S
Sbjct: 3048 DSKGTSDV-LLQVETIAQEHSTLSQQVDE-KCSFLETKLQGIG------HFQNTIREMFS 3099
Query: 6318 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL-----FSQA 6372
+ + D+++ + A + + ET +E + +K++ M N N A
Sbjct: 3100 QFAEFDDELD-----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 3154
Query: 6373 FPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK---VLFTSL 6429
E + I+ L L + + L R Q++ ++++ F + LK +L
Sbjct: 3155 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3214
Query: 6430 ADNKYI---------ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
+++ + + N+F+ E+IE +Q + + G+I+ + Q
Sbjct: 3215 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 3274
Query: 6481 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 6540
+ +L + + L + R + L + L +++ AL+ L + E++
Sbjct: 3275 GLE---HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM-VDTEELVA 3330
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 6600
+QK + + ++ + + K + L+ E + R+ A E +++ Q S
Sbjct: 3331 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390
Query: 6601 -------AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR 6653
A+L +A R +LE I E + L+ L +E + + + +
Sbjct: 3391 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3450
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTN 6710
L ++I ++ L+ + + L+Q + G+ L + S D ++S+L+ ++
Sbjct: 3451 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3510
Query: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE-----------FWTQQSVTVPQ 6759
K L+ L + + + +L++WL D+L W QQS
Sbjct: 3511 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS----- 3565
Query: 6760 ELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWT 6818
EL ++++ + L + VD L G +LL+ D ++ +L I +++
Sbjct: 3566 ELRVLQEDI---LLRKQNVD-------QALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3615
Query: 6819 D---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 6875
D L T++ E+ QL +L S H E+ +W+ +E + E +
Sbjct: 3616 DITKLSTDVAKTLEQALQLAR-RLHSTH--EELCTWLDKVEVELLSYETQV--------- 3663
Query: 6876 HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD------KTDFAEQLGAMN 6929
L+ + + + K+L + N L S +V S + + + + N
Sbjct: 3664 ---LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3720
Query: 6930 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK-------QQHRIGD 6982
+ ++++ +T+K++ ++ + +++ +W EK+L +Q +
Sbjct: 3721 ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3780
Query: 6983 QASVQNA-----LKDCQDLEDLIK---------------AKEKEVEKIEQNGLALIQNKK 7022
Q VQ L+ ++DL+K + +K+++K+ +N + Q
Sbjct: 3781 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3840
Query: 7023 EDVSSI--VMSTLRELGQTWANLDHMVGQLKILL--------------------KSVLDQ 7060
E + S + + +T+ L + + + ++ + + +
Sbjct: 3841 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3900
Query: 7061 WSSHKVAFDKINSYLMEARYSLSRFRLLTG---SLEAVQVQVDNL-QNLQDDLEKQERSL 7116
+ HK DK+N + L G S++ V D L +++D++K+ +L
Sbjct: 3901 IAEHKPHIDKMN------KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVAL 3954
Query: 7117 QKFGSITNQLLKECHPPVTETLTNTLKEVNM--RWNNLLEEIAEQLQSSKAL---LQLWQ 7171
+ S + Q + + E+L ++ + + +E+I EQ+ +K + ++ Q
Sbjct: 3955 DEAISQSTQFHDKI-DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQ 4013
Query: 7172 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATW-------------IQDCNDL 7218
+ KQ + + T++ + A +D D V W + D +L
Sbjct: 4014 PLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 4073
Query: 7219 --------LKGLGTVKDSLFFLHELGEQ------LKQQVDASAASAIQSDQL-------- 7256
+ + T+KD+ F+ +L + +KQQ +A+ + D L
Sbjct: 4074 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 4133
Query: 7257 SLSQHLCA-----------------------LEQALCKQQTSLQAGVLDYETFAKSLEAL 7293
+L L A L +A + L+ + + L+A+
Sbjct: 4134 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 4193
Query: 7294 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYRLP 7350
W+ A L P +DL T+++++EELK + +++RLN EL +
Sbjct: 4194 FDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 4252
Query: 7351 LNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7406
+ + +Q+ L W + + R KL+ LL F + + +L TE
Sbjct: 4253 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4312
Query: 7407 KLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 7464
L+ + + G+ + + + H + Q ++ + Q + ++ G L+E ++
Sbjct: 4313 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4372
Query: 7465 KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS--YLPMSGLGSV 7522
KL +L+ +WQ V+ + +QR+ +D +RQ + + E L++WL + L LG +
Sbjct: 4373 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4432
Query: 7523 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7582
P ++ + EV F ++ +Y ++ G+Q+L AE + ++ ++EK
Sbjct: 4433 PETAKEQLNVHMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEK 4489
Query: 7583 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS-QSLPDHHEELHAEQM 7641
W+S +L E+K KL L + + D + L ++ L+ S P + Q+
Sbjct: 4490 WESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQI 4549
Query: 7642 -RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7700
K N V S + + +L L + D+ ++ + +Q +WE++ +L R
Sbjct: 4550 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4609
Query: 7701 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEE 7754
+ + + F E +L EWL ES+ S + ++ I +K+K K++Q+
Sbjct: 4610 GRSLDDARKRAKQFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4667
Query: 7755 IAIAQENKIQLQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+ + G L K S +++ L ++ D+W + R KL+E L
Sbjct: 4668 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4727
Query: 7814 VAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ Q + +L WL +E +LA +P+ D + + ++ + Q+++ K ++
Sbjct: 4728 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD---IDLVMNLIDNHKAFQKELGKRTSS 4784
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
V ++ L+ + D+ +Q + L RW +CA+S+ ++ ++E R +
Sbjct: 4785 VQALKRSARELI---EGSRDDSSWVKVQM--QELSTRWETVCALSISKQTRLEAALRQAE 4839
Query: 7932 KFLDDYSRFEDWLKSSERTAAF----PSSSGVIYTVA---KEELKKFEAFQRQVHECLTQ 7984
+F +WL +E+T F P + T+ KE +KK E + ++++ T
Sbjct: 4840 EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4899
Query: 7985 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL-------QKRVTSILRRLKHFIG 8037
+ + DS ++K + R++ + Q+R+ S L L I
Sbjct: 4900 GDTV-------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL---IA 4949
Query: 8038 QREEFETARDSILVWLTEMDLQLTN-----IEHFSECDVQAKIKQLKAFQQEISLNHNKI 8092
++E E ++L WL + LT+ I E +V+A I + + F +E++ +
Sbjct: 4950 KQELLE----ALLAWLQWAETTLTDKDKEVIPQEIE-EVKALIAEHQTFMEEMTRKQPDV 5004
Query: 8093 EQI 8095
+++
Sbjct: 5005 DKV 5007
Score = 286 bits (731), Expect = 8e-76
Identities = 864/4710 (18%), Positives = 1776/4710 (37%), Gaps = 672/4710 (14%)
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLA-KEFSDKCK 3811
+E G+ + LE +A LR E+ + +E L+++ + V+++ + E L LA K
Sbjct: 360 KEWGKLIIAMLEREKA--LRPEV-ERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSK 416
Query: 3812 ALTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----KSLQQTVLSHEPSVKSVREKGE 3866
L + ++ +A+++ Y L+Q V+ + + + +
Sbjct: 417 RLESGVQ----------------FQNEAEIAGYILECENLLRQHVIDVQILIDGKYYQAD 460
Query: 3867 ALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADH 3926
L++ V L+D+I L+++ + S G+ + E + +I
Sbjct: 461 QLVQRV--AKLRDEIMALRNECSSVYSKGRILTTE-------------QTKLMISGITQS 505
Query: 3927 LQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQP 3986
L + Q +H L T+ M L + ++ T + S + P
Sbjct: 506 LNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVP 565
Query: 3987 DLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQT 4046
+ +P + + Q++ +K++ D TE+
Sbjct: 566 NFSSGVEPNSLQTLKLMQIR-----------------------KPLLKSSLLDQNLTEEE 602
Query: 4047 IEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH---SELELNIAQNMVSQ 4103
I K VQ +++ ++E L + L+N K H E E ++ + +S+
Sbjct: 603 INMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISE 662
Query: 4104 VK----------DFVKKLQSKQASV---------------NTIIEKVNKL---TKKEE-- 4133
++ + + +L+S+ A + N + N+L +KEE
Sbjct: 663 IQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEEE 722
Query: 4134 -----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDY--------HDCMNVVEV 4180
S + I D +L R+ + Q+EE+++ ++ H +E
Sbjct: 723 VAYDWSERNTNIARKKDYHAELMRELD----QKEENIKSVQEIAEQLLLENHPARLTIEA 778
Query: 4181 FLEKFTTEWDNLAR-------------------SDAESTAVHLEALKKLALALQ-----E 4216
+ T+W + + +DA+ +L LK A+Q +
Sbjct: 779 YRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKD---AIQRKYSCD 835
Query: 4217 RKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKI----------- 4265
R +I L+D Q+ +E +KE + + S + + + +I+ K
Sbjct: 836 RSSSIHKLEDLVQESME-----EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSI 890
Query: 4266 ---------QVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQS-----PPP----- 4306
Q+ +T ++ V + +W + P EA+ S PPP
Sbjct: 891 PIKAICDYRQIEITIYKDDECVLANNSHRAKW-KVISPTGNEAMVPSVCFTVPPPNKEAV 949
Query: 4307 DMAQNLLMDHLAICSELEAKQMLLKS------LIKDADRVMADLGLNERQVIQKALSDAQ 4360
D+A + + + + + +KS LI + DR+ A + + ++
Sbjct: 950 DLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPG------ 1003
Query: 4361 SHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSK 4420
H LS+L + +L S+++Q VF + Q + K
Sbjct: 1004 EHQQVLSNLQSRFEDFLED--SQESQ----VFSGSDITQ------------------LEK 1039
Query: 4421 QVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCS 4480
+V CK + YQ EL+K +E+ E + ++Y S ++
Sbjct: 1040 EVNVCK------QYYQ-----------ELLKSAEREEQEE------SVYNLYISEVRNIR 1076
Query: 4481 HRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ 4540
RL+ E L+ + + D L ++ + L E L L N E+
Sbjct: 1077 LRLENCEDRLIRQIRTPLERDD----LHESVFRITEQEKLKKELERLKDDLGTITNKCEE 1132
Query: 4541 SPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAK---DKFYKVQE 4597
Q + +P+L +LN + + N + +++ DK V
Sbjct: 1133 --------FFSQAAASSSVPTLRS--------ELNVVLQNMNQVYSMSSTYIDKLKTVNL 1176
Query: 4598 AILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGE 4657
+ + +L++L L E EA + + E +S R+ +DE +
Sbjct: 1177 VLKNTQAAEALVKLYETKLCEEEAVIADKNNI------ENLISTLKQWRSEVDEKRQVFH 1230
Query: 4658 AVDELNQKKEGF----------RSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTS 4707
A+++ QK + R W +K LV + + Q + R+ LE
Sbjct: 1231 ALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 1290
Query: 4708 AYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIH 4767
+ + + L+ ++ V+ Q K+ +E P K +LA L +++ + +
Sbjct: 1291 SLKYYRDTYHPLDDWIQQVETTQRKI-QENQPENSK-----TLATQLNQQKMLVSEIEMK 1344
Query: 4768 LEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLD 4827
+ +K Q + + +L T V + V+ Q+ +
Sbjct: 1345 QSKMDE------CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
Query: 4828 WLRRVKAELSGPVYLDL--------NLQDIQEEIRKIQIHQEE-VQSSLRIMNALSH--- 4875
++ + V L +L+ ++EE + ++ ++E V+ + + +S+
Sbjct: 1399 EFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
Query: 4876 --KEKEKFTK---AKELISADLEHSLAELSELDGDIQEALRTRQATLT--------EIYS 4922
K+ EK K +K+ IS++ E+S + EAL+T Q L E +
Sbjct: 1459 TLKDAEKAGKPPFSKQKISSE------EISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1512
Query: 4923 QCQRYYQVFQAANDWL-EDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNL--E 4979
+ ++ + Q + + L ++ + LQ + DV+ E+ + + + + Q +L +
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
Query: 4980 ELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAR 5039
+ L+ + + G +L++ + + + + +D L ++ K
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKK----YQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1628
Query: 5040 EEVIELMNDT--EKKLSEFSLLKTSSSHEAEEKLSE-HKALVSVVNSFHEKIVA---LEE 5093
E + + E+KL+E + + +AE+ E K + + + EK+ A LEE
Sbjct: 1629 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1688
Query: 5094 KASQLEK-------TGNDASKATLSRSMT-----TVWQRWTRLRAVAQDQE---KILEDA 5138
+++E D+ +A T +Q A+ ++ E +LE
Sbjct: 1689 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1748
Query: 5139 VDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALG 5198
VD +V E ++Q K+ KA+ ++ H ++ QSA
Sbjct: 1749 VD------GQVGTTQENLNQQYQKV---------KAQHEKIISQHQAVIIAT---QSAQV 1790
Query: 5199 MLRQQTLSMLQDGAAPTPGEEPPL---MQEITAMQDRCLNMQEKVKTNGKLVKQELKDRE 5255
+L +Q G +P E+ L M+E+ + L EK +++EL E
Sbjct: 1791 LLEKQ-------GQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL---E 1840
Query: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL 5315
+ + W+Q++++ L N ++A +++ L+T+ + E + + + L
Sbjct: 1841 KFDADYTEFEHWLQQSEQELEN----LEAGADDINGLMTKLKRQKSFSEDVISHKGD--L 1894
Query: 5316 GLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILT 5375
TI + ++ E A RD +V+ S AT +E+ R++ ++ +
Sbjct: 1895 RYITISGN----RVLEAAKSCSKRDG-----GKVDTS-ATHREVQRKLDHATDRFRSLYS 1944
Query: 5376 KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435
K +N+ + + G + L +A K L + + ++ + T+
Sbjct: 1945 KCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEETK 2004
Query: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY 5495
Q I + + KL + A L + L I+K G S S + E+
Sbjct: 2005 ALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKS-VNERN 2063
Query: 5496 ILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQN 5555
Q L S + L+ M L ++ +V + K QV + L+ +I +
Sbjct: 2064 EKLQITLTRSLSVQDGLDEM---LDWMGNVESSLKEQGQVP---LNSTALQDIISKNIML 2117
Query: 5556 LQDAAKDMKKFEAELKKLQAALEQAQ-ATLTSPEVGRLSLKEQLSHRQH----LLSEMES 5610
QD A A +K++ +E +T +S + L + S H L++ME
Sbjct: 2118 EQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEE 2177
Query: 5611 LKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE 5670
LK KV+ + + E + L AL + + T + Q MQ + ++
Sbjct: 2178 LKTKVELFE------NLSEKLQTFLETKTQALT-EVDVPGKDVTELSQ--YMQESTSEFL 2228
Query: 5671 QYEQEMKHLQQLIE--GAHREIEDKPVATSNIQELQAQISRHE----ELAQKIKGYQEQI 5724
++++ ++ L L++ +H DK + L + E E + + QEQ+
Sbjct: 2229 EHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQL 2288
Query: 5725 ASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHT 5784
+ K L K T + + + + G EDL L T + T
Sbjct: 2289 DAFQVLVKSLKSWIKETTKKVPIVQP---SFGAEDLGKSLEDTKKLQEKWSLKTP----- 2340
Query: 5785 LLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIH 5844
++ NS IS + + A A+V A L+ E T+
Sbjct: 2341 --------EIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA---VLNGEGTATN----- 2384
Query: 5845 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5904
++EF+ S + D+ +E L ++ +K L L + QK Q+ ++
Sbjct: 2385 -----TEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2439
Query: 5905 ST---KMEAIELKLSESPEPG--RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
KM K ++P P + ++Q+ ++++ E+ +++ EL+ L E L+
Sbjct: 2440 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTE-LLE 2498
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRC 6019
E+ D E + LT + + + ++Q LEE N+ + Q E L++
Sbjct: 2499 EN--PDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ--- 2553
Query: 6020 EADELDSWLLSTKATLDTALSPPK-EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
WL+ K + + L P +P + Q Q +L E + +L+ +
Sbjct: 2554 -------WLVE-KELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQG 2605
Query: 6079 LLLEG------KAHTKDEAEQLAGKLRRLKGSLLEL-----QRALHDKQLNMQGTAQEKE 6127
+L + K++ + K L G L + Q + Q + +
Sbjct: 2606 ILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDK 2665
Query: 6128 ESDVDLTATQSPGVQ---EWLAQARTTWTQQRQSSLQQQKELE--QELAEQKSLLRSVAS 6182
SD+D + S V + + Q T + +Q Q++K+++ Q L E S L
Sbjct: 2666 LSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY 2725
Query: 6183 RGEEILIQ-HSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMR---MKWESLHQE---- 6234
E+ Q ++ D +K + Q L S QM W +E
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2785
Query: 6235 ---FSTKQKLLQNVLEQEQ-------------EQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S K +L+++++ + E+ + N LL K + Q +
Sbjct: 2786 SHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNT 2845
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLF-VATALL 6337
T+ D N+ +E ++ ++S+ K + V W+D + L + L
Sbjct: 2846 IKTNW-DTFNKQVKERENKL----KESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2900
Query: 6338 PEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLL 6397
P E E + + L K++ + ++ N + +++V+ D L+ ++ ++
Sbjct: 2901 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2960
Query: 6398 DSVVNQRCHQMKERLQQILNFQNDLKV-----------------LFTSLADNKYIILQKL 6440
++ + ++ Q+ FQ K L + NKY+ + +
Sbjct: 2961 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQT 3020
Query: 6441 ANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDEL 6499
Q + Q++ ++ A+D + E + K D L + QE S L DE
Sbjct: 3021 QQKSLQALKHQVDLAKRLAQDLVVEAS----DSKGTSDVLLQVETIAQEHSTLSQQVDEK 3076
Query: 6500 MMIIGSRRSGL----NQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQL 6555
+ ++ G+ N + SQ+ +L + G+ D + + KE I+
Sbjct: 3077 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGR-----DAETLQKQKETIKAF 3131
Query: 6556 LDKHKEYFQGLESH------MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKR 6609
L K + ++ M+ TE ++ E L Q + +L RA R
Sbjct: 3132 LKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEA-----LSKQCNKLLDRAQAR 3186
Query: 6610 GVELEYIL----ETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLK 6665
++E + E +S L E L + E ES P VG+ E ++ ++ ++Q K
Sbjct: 3187 EEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGP-VGMETETINQQLNMFKVFQ--K 3243
Query: 6666 SSLNEYQPKLYQVLDDGKRLLISI----SCSDLESQLNQLGECWLSNTNKMSKELHRLET 6721
+ Q K V G+ L+ S S LE L+ + W + K+++ +L+
Sbjct: 3244 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303
Query: 6722 ILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQ 6781
L H R+Q L+ W+ ++ + S E ++V+ + + +D +
Sbjct: 3304 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSA----EFKVVKAQIQEQKLLQRLLDDR 3359
Query: 6782 SSLKSSVLSTGNQLLRLKK-VDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP 6840
S + G ++ + D + +LS +DS+W LL +L + +
Sbjct: 3360 KSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3419
Query: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKA--IHEYLQKYKGFKIDI---NCKQLT 6895
+ + W++ +E + E IG +A + E + ++K + DI N
Sbjct: 3420 FHETLEPLNEWLTTIEKRLVNCEP-----IGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474
Query: 6896 VDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQI-LQGLVTEKIQLLEGLLESWS 6954
+ QS+ +SS++ + K DF++ W I +Q + +LL+ L +
Sbjct: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQV-------WYIEIQEKSHSRSELLQQALCNAK 3527
Query: 6955 EY-ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013
+ E+ V+ + E +K K + + + + L++ I +++ V++ N
Sbjct: 3528 IFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3587
Query: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073
GL L++ D I+ L + + ++ + + L+ L +++ +
Sbjct: 3588 GLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCT 3647
Query: 7074 YLMEARYSLSRF--RLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
+L + L + ++L G EA Q Q+ + L+ + + + L +++ LL+
Sbjct: 3648 WLDKVEVELLSYETQVLKGE-EASQAQM-RPKELKKEAKNNKALLDSLNEVSSALLELVP 3705
Query: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
E L + E N R+ + + I ++++ A + Q++ + S + + E +
Sbjct: 3706 WRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKL 3765
Query: 7192 NELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAI 7251
L +D ++ ++L+ + D + H++ ++ S +
Sbjct: 3766 MSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
Query: 7252 QSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH 7311
L +C + Q Q+ V F ++ E L W+ E + I+ Q P+
Sbjct: 3826 DK-VLKNYDTICQINSERYLQLERAQSLV---NQFWETYEELWPWLTETQSIIS-QLPAP 3880
Query: 7312 SSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL-PLNDKEIKRMQN----LNRHW 7366
+ + T++++ EE + + P +D++N+ G +L L+ E +Q + +
Sbjct: 3881 ALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLY 3940
Query: 7367 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAV--EISGNYQHLLEQQR 7424
S I +R L + Q F +K + +E L + ++L IS + + EQ
Sbjct: 3941 SQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQIS 4000
Query: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRA 7480
++ +M Q + ++ G+ ++ + D+D KL + W+ +
Sbjct: 4001 ENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLV 4060
Query: 7481 QQRRG----IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ--ARTLFD 7534
++R +++ + W + + ++ + L G+ + QQ A T+ +
Sbjct: 4061 EEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE 4120
Query: 7535 EVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQK 7594
E+ Q + + G +L+ + + ++ + E+ W S + +++
Sbjct: 4121 EID-------GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRI 4173
Query: 7595 KKLAFLLK-------------DWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE---ELHA 7638
KL ++ DW G S+ + T + + Q + + + E +
Sbjct: 4174 DKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQ 4233
Query: 7639 EQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
+Q+ + L + Q LL L D + + + L+ W+ L ++
Sbjct: 4234 QQIEMERLNH----------QAELL---LKKVTEESDKHTVQDPLMELKLIWDSLEERII 4280
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN----GDILIEEMIEKLKKDYQEE 7754
R+ ++ L F EL WLT E +S+ GD E IE K +
Sbjct: 4281 NRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE-IELAKHHVLQN 4339
Query: 7755 IAIAQENKIQ-LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+A ++ ++ + + G L ++S +AS ++ KL +N RWQ++L+ R ++L L
Sbjct: 4340 DVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGAL 4399
Query: 7814 VAVQQLDKNMSSLRTWLAHIESEL--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ + L+ WL E L +KP+ E + +LN E+ E
Sbjct: 4400 RQAKGFHGEIEDLQQWLTDTERHLLASKPL---GGLPETAKEQLNVHMEVCAAFEAKEET 4456
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
S++ + +L C A +I Q NL +W ++ ER+ K+EE L
Sbjct: 4457 YKSLMQKGQQMLARCPKSAET----NIDQDINNLKEKWESVETKLNERKTKLEEALNLAM 4512
Query: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
+F + F +WL +E+T S +I ++ + + F +V+ Q+ ++K
Sbjct: 4513 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
Query: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
L ++ +K ++ RW+ + +R+ R L + ++F A ++
Sbjct: 4573 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4632
Query: 8052 WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPL 8109
WL E + L + +E ++ D ++ ++ Q K FQ+ + H+ + G L EK+
Sbjct: 4633 WLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLA 4692
Query: 8110 DAAI-IEEELDELRRYCQEVFGR-VERYHK 8137
D + +++ L ELR + G+ VER +K
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNK 4722
Score = 278 bits (712), Expect = 1e-73
Identities = 768/4289 (17%), Positives = 1650/4289 (38%), Gaps = 539/4289 (12%)
Query: 1285 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1344
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 1005 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 1064
Query: 1345 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1394
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 1065 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 1121
Query: 1395 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1454
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 1122 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 1180
Query: 1455 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1514
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 1181 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 1236
Query: 1515 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1547
Q S F T E +I +L + G+ L+ +
Sbjct: 1237 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 1296
Query: 1548 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1604
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 1297 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1349
Query: 1605 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664
CQ SA K + A QQ + RR Q++ + ++ +
Sbjct: 1350 ECQKYAEQYSATV-------KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEF 1400
Query: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEVVSQASFYSKL 1723
L ++ +T + + + + D +K +E E + ++ + E V +A K
Sbjct: 1401 MDLRTRYTALVTLM--------TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA----KE 1448
Query: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
LQ S S KD K K P ++I+ + + + +Q E L +
Sbjct: 1449 LQKWVSNISKTLKDAEKAGK-------------PPFSKQKIS-SEEISTKKEQLSEALQT 1494
Query: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
I+LFL+ +H D + E + EL+ L + +L +
Sbjct: 1495 ----IQLFLA------------------KHGDKMTDEE--RNELEKQVKTLQESYNLLFS 1530
Query: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNS 1903
E L LQ +++ + E V ER+Q + L GI L QT
Sbjct: 1531 ESLKQLQ-ESQTSGDVKVEEKIVAERQQ----------EYKEKLQGICDLLTQT------ 1573
Query: 1904 MNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLC 1963
E+ LI Q A + V L SK + E + + +A L
Sbjct: 1574 ----ENRLI------GHQEAFMIGDGTVELKKYQSKQE--------ELQKDMQGSAQALA 1615
Query: 1964 GEVERIQNLL---GTKQSEADALAVLKKAFQDQK---EELLKSIEDIEERTDK---ERLK 2014
V+ +N L G K S+ D A++++ + K E+L E ++ DK +K
Sbjct: 1616 EVVKNTENFLKENGEKLSQEDK-ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 1674
Query: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKD----------KAKQIAQKD-------- 2056
E T +++ QLE+ E+ L WL + K KQ+ +++
Sbjct: 1675 EET-----EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGD 1729
Query: 2057 --VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
A E + N LE D EN L ++YQ +K+ K++ +
Sbjct: 1730 GKSAIGEEDEVNGNLLETDVDGQVGTTQEN---------LNQQYQKVKAQHEKIISQHQA 1780
Query: 2115 VIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLD-NFTSKGKHLLSELKKIHSSDFSL 2173
VI+ + + + + + E K K+ K+L ++ + ++K HS L
Sbjct: 1781 VIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1839
Query: 2174 VKTDMEST-VDKWLDVSEKLEEN-----------MDRLRVSLSIWDDVLSTRDEIE--GW 2219
K D + T + WL SE+ EN M +L+ S +DV+S + ++
Sbjct: 1840 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1899
Query: 2220 SNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETP 2278
S N V + A++ S D + +E + ++ + R L+SK N L K
Sbjct: 1900 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----- 1954
Query: 2279 PDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA 2338
DL+ K +H + + + G L A K +++ K
Sbjct: 1955 --------DLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPIAVDPK--------- 1994
Query: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQENLNSL--CRKYHSAELESLGRAMTGLIKKH 2396
L++ K +Q ++ SQQ + ++ L R + + + ++ ++
Sbjct: 1995 --NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2052
Query: 2397 EAVSQLCSKTQASLQESLEKHFS--ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
E +S+ ++ LQ +L + S + + E +W +++ KE +S L+ +
Sbjct: 2053 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2112
Query: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
+ ++ QS ++A+ ++ + SS+Q ++ + F + +
Sbjct: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172
Query: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----ENLGESKQHIPEKKNEV--HKV 2567
+++ +++ FE+ KL ++ + +++ E Q++ E +E HK
Sbjct: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 2232
Query: 2568 EM-FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSC 2626
+ L LL S S + +L + + S+ ++ ++ KE + SC
Sbjct: 2233 HLEVLHSLLKEISSHGLPSDKALVLEKTNN--------LSKKFKEMEDTIKEKKEAVTSC 2284
Query: 2627 QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGE 2683
Q L + L ++L+S W+K ++ + + G++D L K L ++Q+ +K
Sbjct: 2285 QEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAED-LGKSLEDTKKLQEKWSLKTP 2340
Query: 2684 GEVKLN----------MAIGKGEQALRSSNKEGQRVIQTQ--LETLKEVWADIMSSSVHA 2731
K+N A+ +A+ ++ K G V+ + +E WA+ +S+
Sbjct: 2341 EIQKVNNSGISLCNLISAVTTPAKAI-AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2399
Query: 2732 QST-------------------LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ-PQP 2771
T L + +S+ E + + QW++ +++ Q P P
Sbjct: 2400 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2459
Query: 2772 GLKEKF-VLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE---ELKTQ 2827
E ++ +S +E + + + L K EL E+ D ++ E+ ++
Sbjct: 2460 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2519
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
+ ++ + ++ +K+EE + + + WL + + +S D + +
Sbjct: 2520 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2579
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTA-SGCELMHTEMQALRADWKQWEDSVFQ 2946
+++ L L + P+ +Q T A G E +LR K+ +V Q
Sbjct: 2580 QQVQIL----------LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2629
Query: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSALLKTWAQQLTLLEGKNTDEEIV 3003
L + S + ++QA+ Q+ +LL++ + +L+ L+ K + V
Sbjct: 2630 KWDSLTG----------QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2679
Query: 3004 ECWHKG-QEILDALQKAEPRTEDLKSQLNELCRFSRDLST----------YSGKVSGLIK 3052
+ L+ QK + + K Q+ DLS S ++ G++K
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2739
Query: 3053 EYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS 3110
+ + +A Q+ + +F++ RDFQ WL K K I + + +
Sbjct: 2740 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2799
Query: 3111 LQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQ 3170
++ ++F H +++GE L + +Q ++ K +W F+ + +
Sbjct: 2800 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2859
Query: 3171 KESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI 3230
+E+ L+ + ++ E + W+ K + + E L D KL+S+ +E+
Sbjct: 2860 RENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCL-DPAEGENSIAKLKSLQKEM 2918
Query: 3231 HCYEPQLNRLKEKAQQLW------------EGQAASKSFRHRVSQLSSQYLALSNLTKEK 3278
+ + L A L E ++ + QL S+ L N+T +K
Sbjct: 2919 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT-QK 2977
Query: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIH-MLDSYCHPTSDKSVLDSRTLKLEALL-SV 3336
+ E + KE D IH L S + ++L ++ L+AL V
Sbjct: 2978 FKEFQEVSKESKRQLQCAKEQLD-----IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV 3032
Query: 3337 KQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396
K + ++V +S +G + Q++++ ++L S LE L
Sbjct: 3033 DLAKRLAQDLVVEASDS-------KGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 3085
Query: 3397 KWTSYQDGVR----QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSL 3452
+Q+ +R QF+ + D +++ + K T+ K L + S +
Sbjct: 3086 GIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNA 3145
Query: 3453 LETIEVKGAGMTEHYVTQL-----ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507
+T ++ A TE L +L+ L ++ + +RA+ + E ++ +E+
Sbjct: 3146 NKTCKMMLA--TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 3203
Query: 3508 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE------------GQAL 3555
LK F + L + +E + + + T L + Q E GQ L
Sbjct: 3204 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 3263
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ S S Q + L+ + W+ ++++ Q + + +
Sbjct: 3264 IQS-------AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 3316
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
+ W+ EE +++ + +V + + Q++L + + + + A
Sbjct: 3317 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATT 3376
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
+ +++K L +++ L+ +L + ++ + VA + +TL
Sbjct: 3377 AEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-----------ETL 3424
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEE-GEAERLRKEIHDHMEQLKELTSTVRKEHM 3794
E L + + L + G +A K E+ + + L +I +H + L H
Sbjct: 3425 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL----------HQ 3474
Query: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3854
+ G L S + K + Q ++ ++ ++ E+ EK S+ + LQQ +
Sbjct: 3475 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI------EIQEKSH--SRSELLQQALC-- 3524
Query: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG--------KAMMEEIAGFE 3906
+ K E L+ + +V DK+ +L QD + G + + E+I +
Sbjct: 3525 --NAKIFGEDEVELMNWLNEV--HDKLSKL--SVQDYSTEGLWKQQSELRVLQEDILLRK 3578
Query: 3907 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 3966
++ + G L+ Q ++ + A KD A+ + Q+L+ +
Sbjct: 3579 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3638
Query: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4026
H T ++ WL V+ +L L EA + + L+++A+ LL S+
Sbjct: 3639 H----STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3694
Query: 4027 DLSNASVKTTAKDIQQ-----TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQ 4081
++S+A ++ ++ + E+ + + +TQ EEI + Q AD +
Sbjct: 3695 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3754
Query: 4082 L----QNMKRRHSELELNIAQNMVS---QV-KDFVKKLQSKQASVNTIIEKVNKL----T 4129
L + K+ S ++ + Q+ S QV K F ++ + ++ +++ +K+ +
Sbjct: 3755 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3814
Query: 4130 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4189
++E+ K+++ + + +C+ ++ LQ E ++V F E + W
Sbjct: 3815 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLER----------AQSLVNQFWETYEELW 3864
Query: 4190 DNLARSDAESTAVHLEALKKLALALQERKY-AIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248
L + + + + AL+ L Q+ ++ + +L + + I+ +N +L++
Sbjct: 3865 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3924
Query: 4249 H---LEQRWFQLEDL---IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302
+++++ + L IK ++ L+E ++F + ++ E I E L+Q
Sbjct: 3925 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3984
Query: 4303 SP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
P + + + ++ + ++E Q L ++L + + ++A G ++ + KA+ D
Sbjct: 3985 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 4044
Query: 4359 AQSHV----NCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
+ + LV +R L + +F I+ + I E +
Sbjct: 4045 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 4104
Query: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
P V +Q + ++ + + Q E+ + G EL+ E +K V + EL S +DS
Sbjct: 4105 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 4164
Query: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT---QL 4531
+ + R+ +LE+ + + +++ W+ DI ++ ++L T Q+
Sbjct: 4165 LNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV---DIAGGKLASMSPIGTDLETVKQQI 4221
Query: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKD 4590
+ + ++ + + + L + +L + E D + + L L ++ + +
Sbjct: 4222 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD-LAVEEALS----LQDGC 4645
+ +K++ A+LA ++ ++ L+ E V D A+E L+ LQ+
Sbjct: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
A V + +A ++L + G ++ +K+ L + + +TEQR L+
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4398
Query: 4706 TSAYQEHEKMCQQLERQLKSVKEE---QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK 4762
+ + L++ L + + A+E+L ++ + + + K
Sbjct: 4399 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4458
Query: 4763 RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEM 4822
+ + + A I + + + + + + + E T+ E + +++F +
Sbjct: 4459 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4518
Query: 4823 SRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEK 4880
++WL + + L+ L L + +I + ++ EV S + L + +
Sbjct: 4519 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4578
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
F++ ++++ +++ L + + + L R +L + + +++++ + +WLE+
Sbjct: 4579 FSQKQDVVL--IKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4636
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTG 4996
+++ L + L++ + + +K+ + + +F +L HS+ T + L + T
Sbjct: 4637 SEKSLD---SELEIANDPDKIKTQL---AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTS 4690
Query: 4997 KED----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKK 5052
D L+ ++ L + + S + + L+ + A + +I+ + E +
Sbjct: 4691 LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ 4750
Query: 5053 LSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSR 5112
L+E + + HKA + + AL+ A +L + D S + +
Sbjct: 4751 LAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKV 4808
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
M + RW + A++ ++ LE A+ + F++ V E + + + L
Sbjct: 4809 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4868
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
+ L TL++ H F+ +LE++++ L ++L A P + IT ++ R
Sbjct: 4869 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL---AICHPDSITTIKHWITIIRAR 4925
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ--------ETKEYLGNPTIEIDA 5284
+ K + + + L + + ++ W+Q + KE + E+ A
Sbjct: 4926 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4985
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEK 5313
+ E Q + E T + +++K+ + K +
Sbjct: 4986 LIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014
Score = 276 bits (707), Expect = 5e-73
Identities = 777/4352 (17%), Positives = 1650/4352 (37%), Gaps = 709/4352 (16%)
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQ----ADEMDRMKKEYTDCVVTL-----SAFATEAHK 736
++QQ + W E + +K +E+DR++ + T+ +
Sbjct: 955 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 1014
Query: 737 KLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
+ + LE S + D+ +E+ V V Y+ + K+A +E +E ++ +
Sbjct: 1015 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE---REEQEESVYNLY--I 1069
Query: 797 SKLKEQLTKVKECYSPL------------LYESQQLLIPLEELEKQMTSFYDSLGKINEI 844
S+++ +++ C L L+ES + E+L+K++ D LG I
Sbjct: 1070 SEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNK 1129
Query: 845 ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD---- 900
+A +S+ EL +N + ++ S + K T++ VLK+
Sbjct: 1130 CEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSM---SSTYIDKLKTVNLVLKNTQAAEA 1186
Query: 901 -----QTRLQRQ---IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRI 952
+T+L + IAD + ++++ W+ V+ ++ E+ EL+K I
Sbjct: 1187 LVKLYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALED---ELQKAKAI 1242
Query: 953 AQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDI--------LPEQEQQGL 1004
+ E + + + H E QL +R N ++ + L D+ L
Sbjct: 1243 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPL 1302
Query: 1005 QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLAS-VEECRTELDRETKLMPQEGS-- 1061
+ ++++ + +Q P + L + + + L S +E ++++D K Q +
Sbjct: 1303 DDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV 1362
Query: 1062 ---EKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVK--LPVRDPVRDTPGTCHVTL--KE 1114
E +R + + +R+Q +L ++ + +R T T VTL +
Sbjct: 1363 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR-----TRYTALVTLMTQY 1417
Query: 1115 LRAAIDSTYRKLMEDP---DKWKDYTSRFSEFSSWISTNETQLKG-------------IK 1158
++ A DS R E+ ++ K++ + E W+S LK I
Sbjct: 1418 IKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1477
Query: 1159 GEAIDT----------------ANHGEVKRAVEEIRNGVTKRGETLS-----WLKSRLKV 1197
E I T A HG+ + +E RN + K+ +TL LK
Sbjct: 1478 SEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERNELEKQVKTLQESYNLLFSESLKQ 1535
Query: 1198 LTEVSSENEAQKQGDELAKLSSSFK----ALVTLLSEVEKMLSNF--------------- 1238
L E + + + + +A+ +K + LL++ E L
Sbjct: 1536 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKK 1595
Query: 1239 -------------GDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEA----QQL 1281
G E+VKN+ E + + E Q +K L + L EA +QL
Sbjct: 1596 YQSKQEELQKDMQGSAQALAEVVKNT-ENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1654
Query: 1282 LLHHQQKTKR----ISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRER 1337
L +Q K ++ ++ +++A +Q E E K+E+ LD L +
Sbjct: 1655 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE--------ESKTKIENLLDWLSNVDKD 1706
Query: 1338 QER----RIQVTLRKWERFETN--------KETVVRYLFQTGSSHERFLSFSSLESLSSE 1385
ER QV + F+ ++ V L +T + ++ E+L+ +
Sbjct: 1707 SERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ---VGTTQENLNQQ 1763
Query: 1386 LEQTKEFSKRTES------IAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439
++ K ++ S IA Q+ ++ E L P+ K+ LQ+ K +K +
Sbjct: 1764 YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1823
Query: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK----- 1494
E+ +K ++ + + F +++ W+ + E+EL LE + ++ ++++K
Sbjct: 1824 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1883
Query: 1495 ---VTIQEIESKLSSIVG--LEEEAQSFA-----QFVTTGESARIKAKLTQIRRYGEELR 1544
V + + + +I G + E A+S + + T+ ++ KL L
Sbjct: 1884 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1943
Query: 1545 EHAQCLEGTILGHLSQQQKFEE-------NLRKIQQSVSE-FEDKLAVPIKICSSATETY 1596
L + + + Q +E+ L+ + + S+ + +AV K E
Sbjct: 1944 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEET 2003
Query: 1597 KVLQEHMDLCQ-ALESLSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQ 1654
K LQ + Q A+E L + ++ + +Q+ + +YED+ + ER
Sbjct: 2004 KALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERN 2063
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
L+ L ++ L L W+ E+ +K +G++ L +++
Sbjct: 2064 EKLQITLTRSLSVQDGLDEMLDWMGNVESS------------LKEQGQVPLNSTALQDII 2111
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKMMKL----HLEQLDERWRDLPQIINKRINFLQSV 1770
S+ + + ++S + ++ K M+ L + +DL ++ + +
Sbjct: 2112 SKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 2171
Query: 1771 VAEHQQFD---ELLLSFSVWIKLFL-SELQTTSEISIMDHQVA-LTRH-KDHAAEVESKK 1824
+A+ ++ EL + S ++ FL ++ Q +E+ + V L+++ ++ +E K
Sbjct: 2172 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 2231
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSH 1884
L+ L L ++ S G D L+ K + + F+E ++ ++ A++ E L +
Sbjct: 2232 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2291
Query: 1885 ASLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKALE--------------SA 1929
L ++ L+ + E T + + +DL +L++ K L+ ++
Sbjct: 2292 QVL---VKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2348
Query: 1930 AVSLDGILS------KAQYHLKIG-----------------SSEQRTSCRATADQLCGEV 1966
+SL ++S KA +K G +++ TS + +
Sbjct: 2349 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2408
Query: 1967 ERIQNLLGTKQSEADA-LAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPT-RQALQQ 2023
E + LL K +E + L+ L+KA Q++ +++ ++ + + K ++ PT +A++
Sbjct: 2409 EDLGLLLKDKIAELNTKLSKLQKA-QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2467
Query: 2024 RLRVFNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRLI 2081
++ E EL + +++ LKDK ++ ++ D AP + + ++ W + +L
Sbjct: 2468 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2527
Query: 2082 HENQGQCCGLIDLMREYQNLKSAVSK-VLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ Q + + + ++Q +++ + + ++E V V D L + +
Sbjct: 2528 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2587
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLR 2200
+ ++ + T+ G+ +LS + S +VK + + KW ++ +L + D +
Sbjct: 2588 EFATRKPQYEQLTAAGQGILSRPGE-DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWID 2646
Query: 2201 VSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE--------------ELLKE 2246
++ V ST+ + + + +++ +S+LDN L + E ++
Sbjct: 2647 QAI-----VKSTQYQ------SLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695
Query: 2247 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLE----HAKEITEVA 2302
+ E++ + +++ + DL L K ++++A+L ++LE K++ + A
Sbjct: 2696 MKQEIQQEKKQIKVAQALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKA 2748
Query: 2303 KG---TLKDFTAQSTQVEKFINDITTWF-TKVEESLMN---CAQNETCEAL-KKVKDIQK 2354
+ L+ A S Q ++ D W TK EE + A+ + E+L K KD K
Sbjct: 2749 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2808
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
L +Q T +L K +E +L + + + ++ + + L+ESL
Sbjct: 2809 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2868
Query: 2415 EK--HFSESMQEFQEWFLGAKAAAKE----SSDRTGDSKVLEAKLHDLQNILDSVSDGQS 2468
EK + E ++ W + +E G++ + AKL LQ +D G
Sbjct: 2869 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI--AKLKSLQKEMDQ-HFGMV 2925
Query: 2469 KLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFE 2528
+L T + K++V+ + + ++ +Q K L++ + F+
Sbjct: 2926 ELLNNTANSLLSVCEIDKEVVTDENKSLI---QKVDMVTEQLHSKKFCLENMTQKFKEFQ 2982
Query: 2529 DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRG 2588
+ ++ + +E+ + + S+ + + + + L L + +L+Q
Sbjct: 2983 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 3042
Query: 2589 QLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2648
+ + + G + H L + EK + LQ + ++ M+
Sbjct: 3043 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3102
Query: 2649 AIQDRLAC-------AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQA--- 2698
D L AE+ K+T++ L +++ ++ M + E +
Sbjct: 3103 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3162
Query: 2699 ------LRSSNKEGQRV----------IQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
L + +K+ ++ ++ ++ L+E ++ + S+ Q E SQ
Sbjct: 3163 VGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 3222
Query: 2743 NDYVERKNQLEQW-MESVDQKIE-HPLQPQ--------PGLKE---KFVLLDHLQSILSE 2789
+E + +Q M V QK E PLQ + GL + K L+ L +
Sbjct: 3223 PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3282
Query: 2790 AEDHTRALHRLIA-KSRELYEK-TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE-EIV 2846
+ L++ +A ++ +L E F+D + L + VA +K E ++V
Sbjct: 3283 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3342
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKE--LIDSR------- 2897
K + + D S E + R + ++ K+ +K+ L+DSR
Sbjct: 3343 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3402
Query: 2898 -EIGASRLSRV--------ESLAPEVKQNTTAS----GCELMHTEMQALR---ADWKQWE 2941
E +L + E+L P + TT CE + T+ L A K E
Sbjct: 3403 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3462
Query: 2942 DSVFQTQSCLENLVS--------------QMALSEQEFSGQVAQLEQALEQFSALLKTWA 2987
D + L VS M S+ +FS QV +E + S ++
Sbjct: 3463 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS-QVWYIEIQEKSHS---RSEL 3518
Query: 2988 QQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR---TEDLKSQLNELCRFSRDL---- 3040
Q L K E+ VE + E+ D L K + TE L Q +EL D+
Sbjct: 3519 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3578
Query: 3041 ----------------------STYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ--QRF 3076
K+ + Y + ++ + EQ LQ +R
Sbjct: 3579 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3638
Query: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136
+ WL ++ E S + + +E E++N + L+ +
Sbjct: 3639 HSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3698
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
L L+ +G++ V E ++ + QK ++ ++ + F+ +A+ W+
Sbjct: 3699 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3758
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE------- 3249
++TEK +L L R EQ + + L+ + ++ R K+ L +
Sbjct: 3759 TETEK-------KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3811
Query: 3250 --GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3307
+ +S + ++ ++ Y + + E+ +L+R + NQF +EL W+T+
Sbjct: 3812 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3871
Query: 3308 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3367
++ P + L + + L + E + + + G +L+ + EG +IQ
Sbjct: 3872 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF-SIQ 3930
Query: 3368 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3427
++ + +++ + + L+ A+S+ T + D + Q L ER
Sbjct: 3931 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI----------LESLERIVE 3980
Query: 3428 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3487
LR ++ + + + E++ +E+ ++++ LQ Y +++R
Sbjct: 3981 RLRQPPSISAEVEKIKEQI-----------------SENKNVSVDMEKLQPLYETLKQRG 4023
Query: 3488 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHT----HETTLRDLQ 3543
+E + +S +D+ A V Q+KLDQ + + HT E L D+
Sbjct: 4024 EEMIARSGGT-------DKDISAKAV-----QDKLDQMVFIWENIHTLVEEREAKLLDVM 4071
Query: 3544 EL-QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
EL + + +L+ ++ T++ + P + ++ ++ + + + + + +
Sbjct: 4072 ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDI 4131
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC 3662
V+N E+ A E ++ ++ +DE
Sbjct: 4132 VIN-----------------------LGSELIAACGEPDK--PIVKKSIDE--------- 4157
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
L S + +L ++I LEE +Q+ + + L + DW +++
Sbjct: 4158 ----LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP---- 4209
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER----AVKYLEEGEAERLRKEIHDH 3778
+G L+T++ ++++++ S + + ER A L++ E + + D
Sbjct: 4210 -----IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP 4264
Query: 3779 MEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMEL 3834
+ +LK L + LE L +F L W+ + +L + +
Sbjct: 4265 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 4324
Query: 3835 YEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL---VQDVTLKDKIDQLQSDYQDL 3891
+ +L+K+ LQ VL+H+ +V++V + G L+E + L++K++ L +Q++
Sbjct: 4325 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4384
Query: 3892 CSIGKAMMEEI-------AGFEDRLNNLQ------------------------------- 3913
+ +++ GF + +LQ
Sbjct: 4385 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4444
Query: 3914 -----------------MKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
KG ++ +C + + Q+++ K+ + ++ +
Sbjct: 4445 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN----NLKEKWESVETKLNER 4500
Query: 3957 YQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQAR 4016
LE L + ++LQ WL+ + L + +P L + Q+ + +
Sbjct: 4501 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN 4560
Query: 4017 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQ 4076
++ + + + D + +K ++ +Q I+ L+ Q+ WE++ E L
Sbjct: 4561 SHREQIIEL-DKTGTHLKYFSQ--KQDVVLIKNLLISVQS---RWEKVVQRLVERGRSLD 4614
Query: 4077 DADQQLQNMKRRHSEL-------------ELNIA------QNMVSQVKDFVKKLQSKQAS 4117
DA ++ + S+L EL IA + ++Q K+F K L +K +
Sbjct: 4615 DARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSV 4674
Query: 4118 VNTIIEKVNKLTKKEESPEHK-----EINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYH 4172
+T L +K + ++ L D+W +C +S + EE L + +
Sbjct: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734
Query: 4173 DCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK 4230
D + + +L + + D D + ++ K L +R +++ LK ++
Sbjct: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794
Query: 4231 MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAE 4290
+IE + DD VK Q L RW + L K L + S L+EW
Sbjct: 4795 LIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 4853
Query: 4291 EQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNE-- 4348
E + + D + L+ H +LE K+ L D V+A +
Sbjct: 4854 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSIT 4913
Query: 4349 ---------RQVIQKALSDAQSH----VNCLSDLVGQRR---------KYLNKALSEKTQ 4386
R ++ L+ A+ H + L+ L+ ++ ++ L++K +
Sbjct: 4914 TIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDK 4973
Query: 4387 FLM--AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEV----- 4439
++ + + + I +H+ F E + DV K KT K A + Q+ +
Sbjct: 4974 EVIPQEIEEVKALIAEHQ---TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDK 5030
Query: 4440 ----------TGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
+ L+ G + E + ++ K Q++ + +K + L LE+
Sbjct: 5031 GRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEE- 5089
Query: 4490 LVSRKHFKEDFD----KACHWL--KQADIVTF 4515
R+ DFD K W+ K++ ++ F
Sbjct: 5090 --LREFANFDFDIWRKKYMRWMNHKKSRVMDF 5119
Score = 270 bits (691), Expect = 4e-71
Identities = 840/4709 (17%), Positives = 1807/4709 (38%), Gaps = 678/4709 (14%)
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1434
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 629 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 684
Query: 1435 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1494
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 685 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 738
Query: 1495 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1548
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 739 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 795
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1603
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 796 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 851
Query: 1604 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1653
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 852 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 911
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1712
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 912 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 969
Query: 1713 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1761
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 970 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 1021
Query: 1762 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1821
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 1022 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 1073
Query: 1822 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1880
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 1074 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 1133
Query: 1881 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1934
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 1134 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 1190
Query: 1935 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1991
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 1191 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 1233
Query: 1992 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2045
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 1234 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 1285
Query: 2046 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2101
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 1286 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1340
Query: 2102 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1341 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1397
Query: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1398 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1453
Query: 2221 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2267
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1454 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1513
Query: 2268 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2327
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1514 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1570
Query: 2328 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2383
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1571 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1630
Query: 2384 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2437
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1631 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1689
Query: 2438 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2464
+ S+R G +V+E Q N+L++
Sbjct: 1690 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1749
Query: 2465 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2494
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1750 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1809
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1810 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1867
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2612
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1868 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1918
Query: 2613 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2668
+ +E R A +L + +K + D+ E L E
Sbjct: 1919 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1978
Query: 2669 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 1979 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 2038
Query: 2729 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 2039 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 2095
Query: 2789 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2825
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 2096 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 2155
Query: 2826 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2881
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 2156 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 2215
Query: 2882 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2941
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 2216 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 2271
Query: 2942 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2980
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 2272 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2329
Query: 2981 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2330 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2388
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2389 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2442
Query: 3087 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3143
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2443 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2502
Query: 3144 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3203
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2503 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2562
Query: 3204 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3259
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2563 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2622
Query: 3260 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3319
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2623 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2682
Query: 3320 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3378
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2683 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2742
Query: 3379 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3438
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2743 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2802
Query: 3439 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3492
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2803 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2862
Query: 3493 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ--YSVLEGDAHTHETTLRDLQ-ELQVHC 3549
K ++ + +Y+ ++ W+ + Q L++ + + + L+ LQ E+ H
Sbjct: 2863 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2922
Query: 3550 AEGQALLN------SVLHTREDVIPS---GIPQAEDRA----------LESLRQDWQAYQ 3590
+ L N SV ++V+ + Q D LE++ Q ++ +Q
Sbjct: 2923 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 2982
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQV--DEWLKTAEEKKWHEEVTAYRDEVEEVGARAQ 3648
E++ Q +L + + Q +++L + ++ + + A + +V+ AQ
Sbjct: 2983 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ--KSLQALKHQVDLAKRLAQ 3040
Query: 3649 EILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3705
+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 3041 DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 3100
Query: 3706 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3765
+ ++A +T+ K+ +T++ LK +E L ++ + + K +
Sbjct: 3101 FAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKTCKMMLA 3154
Query: 3766 GEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEY 3820
E +++++ +Q +L + +E + +EF K K + + +
Sbjct: 3155 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 3214
Query: 3821 QEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK 3880
+E ME QL+ +K Q K++
Sbjct: 3215 EEHEESQGPVGMETETINQQLNMFKVFQ-----------------------------KEE 3245
Query: 3881 IDQLQSDYQDLCSIGKAMMEEIA------GFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 3934
I+ LQ QD+ +G+ +++ A G E L+++ + TL +
Sbjct: 3246 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK------------ 3293
Query: 3935 VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSR-QDTLQQCQAWLSAVQPDLEPSPQ 3993
AQR Q E L H R QD L+ +W+ + +L + +
Sbjct: 3294 -----------------VAQRAAQLQEALL--HCGRFQDALESLLSWMVDTE-ELVANQK 3333
Query: 3994 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK--- 4050
PP + + +K +QEQ LL + D ++V+ ++ ++ T E
Sbjct: 3334 PPSAEFKVVKA-----QIQEQK-----LLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383
Query: 4051 --LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM----KRRHSELELNIAQNMVSQV 4104
L Q L WE + + K+E ++QL+ + ++ H LE +
Sbjct: 3384 KILKQLSLLDSRWEALLN-KAET------RNRQLEGISVVAQQFHETLE---------PL 3427
Query: 4105 KDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4164
+++ ++ + + I + +KL +E+ +HK + ++
Sbjct: 3428 NEWLTTIEKRLVNCEPIGTQASKL--EEQIAQHKALE--------------------DDI 3465
Query: 4165 LQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ + H +++ + + E ++ +S + + V + +QE+ ++ +L
Sbjct: 3466 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY-------IEIQEKSHSRSEL 3518
Query: 4225 KDQKQKMIEHLNLDDKEL------VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVV 4278
Q + D+ EL V ++ S L + + E L K++ ++ V + L
Sbjct: 3519 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3578
Query: 4279 QSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDAD 4338
Q+ Q L+ N E LKQ+ ++ L I +LEA +K+ KD
Sbjct: 3579 QNVDQALL--------NGLELLKQTTGDEV--------LIIQDKLEA----IKARYKDIT 3618
Query: 4339 RVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQI 4398
++ D+ Q +Q A +H +L K + LS +TQ L + SQ
Sbjct: 3619 KLSTDVAKTLEQALQLARRLHSTH----EELCTWLDKVEVELLSYETQVLKG--EEASQA 3672
Query: 4399 QQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL--WAQGRELMKEVTEQ 4456
Q P ++ K+ K K+ SL + + L W L K V E
Sbjct: 3673 QMR-------------PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED 3719
Query: 4457 EKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD--IVT 4514
+ + V D++ QK ++E++ ++ + F + D W+ + + +++
Sbjct: 3720 N--------ERYRLVSDTITQK----VEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3767
Query: 4515 FPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKL 4574
+I L E + QL + + +++++ L ++G I+ + +E + + +KL
Sbjct: 3768 LGDIRL--EQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3825
Query: 4575 NALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLA 4634
+ + + ++ I + +++ +++ A ++ E L+E ++ +S++P
Sbjct: 3826 DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI---ISQLPAPAL 3882
Query: 4635 VEEAL-SLQDGCRAILDEVAGLGEAVDELNQKKEGFR--STGQPWQ-PDKMLHLVTLYHR 4690
E L Q+ R + + +A +D++N+ S G+ + +K + TLY +
Sbjct: 3883 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3942
Query: 4691 LKRQTEQRVSLLEDTTS-AYQEHEKMCQ---QLERQLKSVKEEQSKVNEETLPAEEKLKM 4746
+K ++R L++ S + Q H+K+ Q LER ++ +++ S ++ E +E++
Sbjct: 3943 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPS-ISAEVEKIKEQISE 4001
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+++ ++ + + + E++ + + +Q ++ + I V
Sbjct: 4002 NKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVE 4061
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQI-------- 4858
E E++++ ++ + W + L + ++D Q+ IR ++
Sbjct: 4062 EREAKLLDVMELAEKF-----WCDHMS--------LIVTIKDTQDFIRDLEDPGIDPSVV 4108
Query: 4859 --HQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELSELDGDIQEA 4909
QE ++ ++ L + ELI+A ++ S+ EL+ + +A
Sbjct: 4109 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4168
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEENLKSHMEFF 4968
+ R L E +Y QA DW++ A +L ++ G D+E+ ++ ++ +F
Sbjct: 4169 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 4228
Query: 4969 STEDQFHSNLEEL-HSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027
S Q +E L H L + + + K ++ + L+L + + L+
Sbjct: 4229 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4288
Query: 5028 CTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 5087
+Q A +E++ + TE LSE + E +L++H L + V +
Sbjct: 4289 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVG-GDPKAIEIELAKHHVLQNDVLAHQST 4347
Query: 5088 IVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNN 5147
+ A+ + + L ++ + L + + QRW + + +++ L+ A+ + GF+
Sbjct: 4348 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4407
Query: 5148 KVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSM 5207
+++ + + + L S L H E ++ L Q+ M
Sbjct: 4408 EIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4467
Query: 5208 LQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCW 5267
L A E + Q+I ++++ +++ K+ +++ L + W
Sbjct: 4468 L---ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
Query: 5268 VQETKEYLG---NPTIEIDA---QLEELQILLTEATNHRQNIEKMAE--------EQKEK 5313
+ + ++ L P++ +D Q++E ++ E +HR+ I ++ + QK+
Sbjct: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
Query: 5314 YLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
+ + +L S S V ++ + D K +Q +L +++ K L +
Sbjct: 4585 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4644
Query: 5374 LTKL----KAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK 5429
L K KT + Q K QK LG + + + + L++ L K
Sbjct: 4645 LEIANDPDKIKTQ-LAQHKEFQKSLGAK-----HSVYDTTNRTGRSLKEKTSLADDNLKL 4698
Query: 5430 IGKLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN 5486
L+EL + ++ R +KL +A ++ + L+ ++ W+ + +
Sbjct: 4699 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE---------- 4748
Query: 5487 SASQLREQYILH------QTLLEESKEIDSELEAMTEKLQYLT---------SVYCTEKM 5531
QL E +H L++ K EL T +Q L S + +
Sbjct: 4749 --PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4806
Query: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV-- 5589
Q+ EL E + + + L+ A + ++F + + L L +A+ TL V
Sbjct: 4807 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4866
Query: 5590 -GRLSLKEQLSHRQHLLSEMESLKPKV-QAVQLCQSALRI--PEDVVASLPLCHAALRLQ 5645
+L+ + + + ++E + ++ +A + + L I P+ + + H ++
Sbjct: 4867 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITT---IKHWITIIR 4923
Query: 5646 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI--EDKPVATSNIQEL 5703
+ A Q + +A+ ++ ++ L ++ A + +DK V I+E+
Sbjct: 4924 ARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 4983
Query: 5704 QAQISRHEELAQKIKGYQEQIASLNSKCK 5732
+A I+ H+ +++ Q + + K
Sbjct: 4984 KALIAEHQTFMEEMTRKQPDVDKVTKTYK 5012
Score = 270 bits (691), Expect = 4e-71
Identities = 774/4191 (18%), Positives = 1624/4191 (38%), Gaps = 555/4191 (13%)
Query: 4702 LEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVL 4761
L S + H+ + + +E S+KE +K++E + A KL Y L+ L
Sbjct: 631 LPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLT-YAEKLHRLESQYAKL 687
Query: 4762 KRVTIHLEDLAPHLDPLA--YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
+ + E HLD L +A +++ W E + + +E + + + D+
Sbjct: 688 LNTSRNQER---HLDTLHNFVSRATNEL-IWLNEKE--EEEVAYDWSERNTNIARKKDYH 741
Query: 4820 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4879
E+ R LD N++ +QE ++ + + ++ A +
Sbjct: 742 AELMRELDQKEE-------------NIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWS 788
Query: 4880 KFTKAKELISADLEHSLAELSELDGDIQEA---LRTRQATLTEIYSQCQR---YYQVFQA 4933
+ + + ++ + A E D +EA LR + + YS C R +++
Sbjct: 789 WILQLCQCVEQHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYS-CDRSSSIHKLEDL 846
Query: 4934 ANDWLEDAQELLQ-------LAGNG-----LDVESAEENLKSHMEFFSTED--QFHSNLE 4979
+ +E+ +ELLQ L G L +++ LK+ + + D Q +
Sbjct: 847 VQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIY 906
Query: 4980 ELHSLVATLDP------LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL-LQRCTAQW 5032
+ V + +I PTG E + V + + D +++ Q W
Sbjct: 907 KDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW 966
Query: 5033 HDYQKAREEVIE---LMNDTEK-KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI 5088
H+ + V+ L+N+ ++ + S + +KT EH+ ++S + S E
Sbjct: 967 HESHINMKSVVSWHYLINEIDRIRASNVASIKTMLP-------GEHQQVLSNLQSRFEDF 1019
Query: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
LE+ +G+D ++ L + + Q + L A+ +E+ E++V + + ++
Sbjct: 1020 --LEDSQESQVFSGSDITQ--LEKEVNVCKQYYQELLKSAEREEQ--EESV--YNLYISE 1071
Query: 5149 VKKATEMIDQLQDKLPG---SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTL 5205
V+ ++ +D+L + E+ E + + + ELE+ + LG + +
Sbjct: 1072 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 1131
Query: 5206 SMLQDGAAPTPGEEPPLMQEITAM---QDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262
AA + P L E+ + ++ +M K V LK+ + E +
Sbjct: 1132 EFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 1189
Query: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTIL 5321
+ + E + + + I+ + L+ +E RQ + +E QK K +
Sbjct: 1190 LYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS----- 1243
Query: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
E+ E LD + D++ E Q + QI +DL I LK
Sbjct: 1244 -DEMFKTYKERDLDFDWHKEKADQLVE------RWQNVHVQIDNRLRDLEGIGKSLKYYR 1296
Query: 5382 DN-------VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLT 5434
D + Q +T Q+ + E NSK + QK L ++ + + K
Sbjct: 1297 DTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1355
Query: 5435 ELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW-IEKAKVLAHGTIAWNSASQLRE 5493
E + T++ E + Y M++ K +++ ++ + + LR
Sbjct: 1356 EQYSATVKDYELQTMT----------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1405
Query: 5494 QYILHQTLL---------------EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538
+Y TL+ EE K ++ E + EK + L + + AE
Sbjct: 1406 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1465
Query: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598
+ +Q I + ++ + ++ L+ +Q L + +T E L + +
Sbjct: 1466 AGKPPFSKQKI-----SSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1520
Query: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP---------LCHAALRLQEEAS 5649
+ L ESLK ++Q Q +++ E +VA +C L Q E
Sbjct: 1521 LQESYNLLFSESLK-QLQESQT-SGDVKVEEKIVAERQQEYKEKLQGICD--LLTQTENR 1576
Query: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 5709
+ H Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + + T N +
Sbjct: 1577 LIGH---QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLK-----EN 1628
Query: 5710 HEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
E+L+Q+ K EQ + KC+ L +KA+ + L + E TE +
Sbjct: 1629 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1688
Query: 5769 SAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGTN-SEISSPPACRS------ 5810
S S V + R T V E++G +EG S I
Sbjct: 1689 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1748
Query: 5811 -PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 5867
V T ++NQ YQ + A E++ + + +T ++Q E + + +
Sbjct: 1749 VDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKE 1805
Query: 5868 DLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5926
LQ++ + LK YE AL +K S+ ++E + +E + E
Sbjct: 1806 KLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE 1857
Query: 5927 SQMAEHQALMDEILMLQDEINELQSSLAEELVS-------------------ESCEADPA 5967
++ +A D+I L ++ Q S +E+++S +SC
Sbjct: 1858 QELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1916
Query: 5968 EQLALQSTLTVLAERM--STIRMKAS-GKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL 6024
++ +T + ++ +T R ++ K +L L D +++ Q Y + L
Sbjct: 1917 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY------QHYEDASCGL 1970
Query: 6025 DSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
+ L + +AT LS P +P +++ QL + + + +I + VA+ +L E +LL+
Sbjct: 1971 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAE-VLLD 2029
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 6142
+ + L + G +L ++++++ +Q +T T+S VQ
Sbjct: 2030 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------------ITLTRSLSVQ 2077
Query: 6143 EWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSVASRGEEILIQHSAAE 6195
+ L + W +SSL++Q + L+ +++ L + +A R I + +
Sbjct: 2078 DGLDEM-LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 2136
Query: 6196 TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH--QEFSTKQKLLQNVLEQEQEQV 6253
+ + S + M+ + + E+L +E TK +L +N+ E+ Q
Sbjct: 2137 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL--SEKLQT 2194
Query: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY 6313
+ L+ V DVP +D + L+Q +E +S+ K+ L L
Sbjct: 2195 FLETKTQALTEV-----DVPGKDVTE-------LSQYMQESTSEFLEHKKHLEVLHSLLK 2242
Query: 6314 DGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAF 6373
+ +++ LP + L L+K KEM + + + K +
Sbjct: 2243 E-----------------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC- 2284
Query: 6374 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQILNFQN--DLKVLFTSL 6429
E D V+ +L + + +V + + L+ Q LK
Sbjct: 2285 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344
Query: 6430 ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------ 6483
+N I L L + P A+ I A++ +G L G E+
Sbjct: 2345 VNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNGEGTATNTEEFWANKG 2393
Query: 6484 --PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540
++++ + Y++L +++ + + LN L+ L+ E + + L + +
Sbjct: 2394 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2453
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET--------QFH 6592
Q + E ++ ++++K + L+ ++ + L K+ + Q
Sbjct: 2454 QQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQML 2513
Query: 6593 TELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 6652
TE+ ++ + + R +LE + + +L + L E + +G + + +
Sbjct: 2514 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2573
Query: 6653 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD------LESQLNQLGECWL 6706
L + Q L +P+ Q+ G+ +L S D ++ QL + + W
Sbjct: 2574 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLRGIVKEQLAAVTQKWD 2632
Query: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
S T ++S ++ + T+YQS L L ++L S+ V + +
Sbjct: 2633 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS----SSLAVSTHPDAMNQ 2688
Query: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 6826
L + +E+ + + L L K + L++ELSR Q +L +
Sbjct: 2689 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSR---QLEGILKSFKD 2743
Query: 6827 VQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDEDNIKNSIGYK--AIHE 6877
V++K Q S H ++ +W+ +K+E N + I K +
Sbjct: 2744 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT-----KKEEQNKSHPISAKLDVLES 2798
Query: 6878 YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG 6937
++ +K F + + +++ + + ++++ S+K QL + +W
Sbjct: 2799 LIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2855
Query: 6938 LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997
V E+ L+ LE +Y+ V+ L W + + L++ D A +N++ + L+
Sbjct: 2856 QVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQ 2915
Query: 6998 ------------------DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST---LREL 7036
L+ E + E + +LIQ K + V+ + S L +
Sbjct: 2916 KEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCLENM 2974
Query: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096
Q + + + K L+ +Q H D + S +Y L+ + SL+A++
Sbjct: 2975 TQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY-LTMLQTQQKSLQALK 3029
Query: 7097 VQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
QVD + L DL + E Q+ +++ Q+ ++C L L
Sbjct: 3030 HQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC-----SFLETKL 3084
Query: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
+ + N + E ++ + L + +D A T+Q+Q++ LK
Sbjct: 3085 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQKETIKAFLKKLEALM 3139
Query: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
++D + C +L T D + I+ D +LS+
Sbjct: 3140 ASNDNAN---KTCKMMLATEETSPDLV--------------------GIKRDLEALSKQC 3176
Query: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322
L ++ ++ + E F L+ + +AEE + Q P + TI +++
Sbjct: 3177 NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV-GMETETINQQL 3235
Query: 7323 EELKG-QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL-------NRHWSLISSQTT 7374
K Q + + +N LG L + + Q L N W ++ +
Sbjct: 3236 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 3295
Query: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRAHELFQAE 7432
+R ++LQ LL F + E+ + ++V TE+ +A + S ++ + Q + +L Q
Sbjct: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355
Query: 7433 MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7492
+ R+ + I +G+++ + D+ + +L+LL ++W+ ++ +A+ R ++
Sbjct: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3415
Query: 7493 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVFLRQQGSY 7550
Q++ E E L +WL + ++ PI Q ++ Q K E +
Sbjct: 3416 VAQQFHETLEPLNEWLTTIEKRLVN---CEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3472
Query: 7551 ILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASMRLEEQKKKLAFLLKD 7603
V G+ L + + + +Q++L EIQEK S S L++ +D
Sbjct: 3473 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532
Query: 7604 WEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQ----MRCKELENAVGSWTDDL 7657
+ + + +KL + ++ L EL Q +R + ++ A+ L
Sbjct: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQAL------L 3586
Query: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
L LLK T + D++ I+ +++E ++ +++++ + + + + L
Sbjct: 3587 NGLELLKQT-----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3641
Query: 7718 NKELCEWLTQMESKV-SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKAS 7776
++ELC WL ++E ++ S +L E + + +E A+ NK L + E ++ A
Sbjct: 3642 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNE-VSSAL 3700
Query: 7777 HES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 7832
E +A E +E + + N+R++ + D I +V+++ ++ QQ D+ + +W+
Sbjct: 3701 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3760
Query: 7833 IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7892
E +L + ++ +L Q+ +I +H + ++ ++ C ++
Sbjct: 3761 TEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC----SE 3815
Query: 7893 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 7952
E S+++ + + + IC ++ ER L++E L +F + Y WL ++ +
Sbjct: 3816 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3875
Query: 7953 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 8012
+ + Y +++ ++ + + E ++ +NK +L E S+++
Sbjct: 3876 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGEGFSIQEKYV 3934
Query: 8013 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8072
+ + +++ V L I Q +F D IL L + +L S +V+
Sbjct: 3935 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS-AEVE 3993
Query: 8073 AKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIEEELDELRRY 8124
KIK+ + + +S++ K+ E + +GE++I +S + + A ++++LD++
Sbjct: 3994 -KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFI 4052
Query: 8125 CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 8184
+ + VE +RE +L D L++ W D + +++ + +
Sbjct: 4053 WENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS-LIVTIKDTQ 4092
Query: 8185 NLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
+ L P ++ ++ +T +D + E D +L +L +A
Sbjct: 4093 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC--------- 4143
Query: 8238 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 8297
G+ DK + I E A+ L + A+++ + Q L
Sbjct: 4144 -GEPDKPIVKKS--------IDELNSAWDSLNKAWKDRIDKLEEAMQAAV-QYQDGLQAV 4193
Query: 8298 RFQIQQTENIIRSKTPTGPELDTSYKGYMKLL---GECSSSIDSVKRLEHKLKEEEESLP 8354
+ + S +P G +L+T + +L E ++RL H+ + + +
Sbjct: 4194 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 4253
Query: 8355 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8414
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 4254 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 4313
Query: 8415 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 8473
L + + + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 4314 LSEQK--PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4371
Query: 8474 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 8533
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4372 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4431
Query: 8534 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 8578
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4432 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4484
Query: 8579 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8629
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4485 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4529
Score = 270 bits (691), Expect = 4e-71
Identities = 734/4041 (18%), Positives = 1546/4041 (38%), Gaps = 628/4041 (15%)
Query: 449 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 1112 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 1169
Query: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
K++ + L +L AE+ +K + K E+V N + I K +
Sbjct: 1170 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE----- 1221
Query: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
+ + +++ + +++A+ + M +T + R+L + ++ ++++ W N
Sbjct: 1222 -VDEKRQVFHALEDELQKAKAISDEMFKTYKE-RDLDFDWHKEKA--DQLVERWQ---NV 1274
Query: 629 VASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ 688
+ L D E + +S +D + L WIQQ + ++ L Q
Sbjct: 1275 HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ 1333
Query: 689 QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT----DCVVTLSAFATEAHKKLSEPLEV 744
Q +L++ +E+KQ ++ DE + ++Y+ D + + + P++
Sbjct: 1334 QKMLVSE------IEMKQ-SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR 1386
Query: 745 SFM--NVKLLIQDLEDIEQR----VPVMDAQYKIITKTAHLITKE--SPQEEGKEMFATM 796
M + L+IQ+ D+ R V +M K + + +E S +EE KE
Sbjct: 1387 RRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA 1446
Query: 797 SKLKEQLTKV-----------KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEII 845
+L++ ++ + K +S S+++ E+L + + + L K + +
Sbjct: 1447 KELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKM 1506
Query: 846 TVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ---- 901
T ER + + L E+ K+ G V++ + ++ ++
Sbjct: 1507 TDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGI 1566
Query: 902 ----TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
T+ + ++ AF + T + KK+ L K + S L +V++ + L
Sbjct: 1567 CDLLTQTENRLIGHQEAFM-IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1625
Query: 958 EEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD 1017
+E G+ + E + ++Q++ A +K C++L ++ EQ ++ L + V
Sbjct: 1626 KENGE-----KLSQEDKALIEQKLNEAKIK-CEQL-NLKAEQSKKELDKVVTTA------ 1672
Query: 1018 LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP--QEGSEKIIKEHRVFFSDK 1075
+K + EK + +EE +T+++ + + SE+ +H+
Sbjct: 1673 -----------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1721
Query: 1076 GPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD 1135
G H I E D V ++ ++ + +T L + K K
Sbjct: 1722 GTHFQEGDGKSAIGE-------EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVK- 1768
Query: 1136 YTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRL 1195
++ IS ++ + + + G+ E+ E L L
Sbjct: 1769 -----AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEK---------EKLQKNMKEL 1814
Query: 1196 KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
KV E + LA+ K +L E+EK +++ + + + + LE L
Sbjct: 1815 KVHYETA-----------LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 1863
Query: 1256 ISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD 1315
+G+ ++ K+ ++ E ++ H+ + I+ V + + +GG D
Sbjct: 1864 EAGADDINGLMTKLKRQKSFSED---VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1920
Query: 1316 RG--HEEL-RKLESTLDGLERSRERQE---RRIQVTLRKWERFETNKETVVRYLFQTGSS 1369
H E+ RKL+ D + ++ + K++ +E ++ L ++
Sbjct: 1921 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980
Query: 1370 HERFLS---FSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL---- 1422
+ LS ++L +LE+TK + S V E L K+ +E+ L + L
Sbjct: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL-KKTAEVLLDARGSLLPAKN 2039
Query: 1423 ------------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470
+ +KS+ E+ +KL+ TL + + + D G+ +
Sbjct: 2040 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN--------VE 2091
Query: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530
KE + +S+A+ IS+ + Q+I + SSI + E+ + F + ++ ++
Sbjct: 2092 SSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQ 2151
Query: 1531 AKLTQI-RRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI- 1588
AK+ + R+ E +H + L + L + + ENL + Q+ E + + + +
Sbjct: 2152 AKMKDLSARFSEASHKHKETL--AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 2209
Query: 1589 CSSATETYKVLQ-------EHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ 1641
TE + +Q EH + L SL I++ + K + + + +
Sbjct: 2210 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNNLSKKFK 2268
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA------- 1694
+ ED ++ KE T+ + L +Q L K L S W++ K + A
Sbjct: 2269 EMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAEDLGKSL 2325
Query: 1695 -DRVKVEGELQL----IQALQNEVVSQASFYSKLLQLKESLFSVAS-------------- 1735
D K++ + L IQ + N +S + S + +++ +V S
Sbjct: 2326 EDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNT 2385
Query: 1736 -----KDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
+ +K + + + DL ++ +I L + +++ Q+ E + W+
Sbjct: 2386 EEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQK 2445
Query: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED- 1845
K QT + + + ++K AE++ ++Q L+ L +L L D
Sbjct: 2446 MNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL--LEENPDT 2503
Query: 1846 ---------LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGIL--RQL 1894
L + K ++ QL + Q +E + ++L +F A L L ++L
Sbjct: 2504 PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEE---SSNNLTQFQTVEAQLKQWLVEKEL 2560
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQ----NAKALESAAVSLDGILSKAQYHLKIGSSE 1950
+V S++ N + + + LQ E + GILS+ E
Sbjct: 2561 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--------PGE 2612
Query: 1951 QRTSCRATADQLCGEVERIQNLLGTKQSEADAL--AVLKKA-FQDQKEELLKSIEDIEER 2007
+ +QL ++ +L G D + A++K +Q L + D++ +
Sbjct: 2613 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2672
Query: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ--KDVAFAPEVDR 2065
A+ Q+L +++ E+ + ++ + + ++ K+ E+ R
Sbjct: 2673 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2732
Query: 2066 EINRLEVTWDDTKRL----IHENQGQCC-------------GLIDLMREYQNLKSAVSKV 2108
++ + ++ D ++ + Q C +D +E QN +S
Sbjct: 2733 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2792
Query: 2109 LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS 2168
L+ V + IKD +D FSK TA++ M K ++G++L L K
Sbjct: 2793 LD------VLESLIKDHKD----FSKTLTAQSHMYEKT------IAEGENL---LLKTQG 2833
Query: 2169 SDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL-----------SIW----------D 2207
S+ + ++ + + W +++++E ++L+ SL ++W +
Sbjct: 2834 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2893
Query: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK----------EFESEV---KNK 2254
++ D EG N + ++ +D H ELL E + EV +NK
Sbjct: 2894 EIKFCLDPAEG--ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2951
Query: 2255 AL------RLEELHSKVNDLKELTKNL--------ETPPDLQFIEADL------------ 2288
+L E+LHSK L+ +T+ E+ LQ + L
Sbjct: 2952 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 3011
Query: 2289 ----------MQKLEHAKEITEVAKGTLKDFTAQST----------QVEKFINDITTWFT 2328
+ L+ K ++AK +D +++ QVE + +T
Sbjct: 3012 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 3071
Query: 2329 KVEESL---------MNCAQNETCEALKKVKDIQKE-------------LQSQQSNIS-- 2364
+V+E + QN E + + E LQ Q+ I
Sbjct: 3072 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF 3131
Query: 2365 --------STQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK 2416
++ +N N C+ + E S + G+ + EA+S+ C+K Q + E+
Sbjct: 3132 LKKLEALMASNDNANKTCKMMLATEETS--PDLVGIKRDLEALSKQCNKLLDRAQ-AREE 3188
Query: 2417 HFSESMQEFQEWFLGAK------AAAKESSDRTGDSKVLEAKLHDLQNIL-----DSVSD 2465
+++ +E++ K A+E + G + ++ N+ + +
Sbjct: 3189 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3248
Query: 2466 GQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQALQDCASEL 2524
Q K V GQ L +K ++ + N ++ K+ + LQ+
Sbjct: 3249 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3308
Query: 2525 GSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES-LDK 2583
G F+D L W+ + EE + ++ + + + + K+ L LL R+S ++
Sbjct: 3309 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL---LQRLLDDRKSTVEV 3365
Query: 2584 LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ------VALQEHEALE 2637
+ + G+ ++ A + L L + + K + R+ Q VA Q HE LE
Sbjct: 3366 IKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3425
Query: 2638 EALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ---IQDILLMKGEGEVKLNMAIGK 2694
+ W+ I+ RL E LE++++Q ++D ++ + L+ A+
Sbjct: 3426 PLNE----WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK---HLHQAVSI 3478
Query: 2695 GEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2754
G+ S++E + ++Q++L+ + + +I S L+ + + E + +L
Sbjct: 3479 GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3538
Query: 2755 WMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK---T 2811
W+ V K+ K + D+ L + + R L I ++ ++
Sbjct: 3539 WLNEVHDKL-----------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3587
Query: 2812 EDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELH 2871
E K T +E+ D + K + + + ++ D L+ + LHS EEL
Sbjct: 3588 GLELLKQTTGDEVLI-IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3646
Query: 2872 RWSD-------------MSGDSSA--------TQKKLSKIKELIDS-REIGASRLSRVES 2909
W D + G+ ++ +K+ K L+DS E+ ++ L V
Sbjct: 3647 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3706
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA-LSEQE---F 2965
A E + A E + ++ + ++ ++Q + ++++ ++E E
Sbjct: 3707 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3766
Query: 2966 SGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR 3022
S +LEQ +Q SA L KT+ + +L K+ +++V+ HK I+ A +E
Sbjct: 3767 SLGDIRLEQ--DQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHK---IMTAC--SEEE 3817
Query: 3023 TEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLC-LQASKGCQ-NKEQILQQRFRKAF 3080
+ +K +L++ ++K Y+ +C + + + Q + Q L +F + +
Sbjct: 3818 KQSMKKKLDK-----------------VLKNYDTICQINSERYLQLERAQSLVNQFWETY 3860
Query: 3081 RDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF--LSE--SENGQHKLNMMLSKGE 3136
+ WL T + +P E T Q+ +E L E +E+ H M + +
Sbjct: 3861 EELWPWLTE---TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3917
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
LL L+ + IQ K AA + ++ ++ AL+ Q F + I + L
Sbjct: 3918 LLE--LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 3975
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL------WEG 3250
+ + + + + ++ + + + ++V ++ +P LK++ +++ +
Sbjct: 3976 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4035
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKEKVSRL-------DRIVAEHNQFSLGIKELQDWM 3303
++K+ + ++ Q+ + + L +E+ ++L ++ +H + IK+ QD++
Sbjct: 4036 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4095
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
D P D SV+ + E + + ++ +++ G ++
Sbjct: 4096 RDLE-------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDK 4148
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
P +++ + + W SL A +LE A+ YQDG++ W+D L
Sbjct: 4149 PIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS 4208
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIE-------VKGAGMTEHYVTQLELQDL 3476
+L + + K E +E + K ++ + Q L +L
Sbjct: 4209 PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMEL 4268
Query: 3477 QERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHE 3536
+ + +++ER K E + ++Q L WL + L + + GD E
Sbjct: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328
Query: 3537 TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALESLRQDWQAYQHRL 3593
L LQ Q+ + +V D+I S + LE L Q WQ +
Sbjct: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
Query: 3594 SETRTQFNNVVNKLRLMEQKFQQVDEWL-----------------KTAEEK-KWHEEVTA 3635
+ + Q + + + + + + + +WL +TA+E+ H EV A
Sbjct: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4448
Query: 3636 YRDEVEE----VGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3689
+ EE + + Q++L + + L +++++ ++ E+ LEE +
Sbjct: 4449 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4508
Query: 3690 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV-DTVMMGKKLKTLEVLLKDMEKGHSL 3748
E +SL + +W + NVA++ + DTV+ ++ +V ++
Sbjct: 4509 NLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF--QIDEHKVFANEVNSHREQ 4565
Query: 3749 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3808
+ + G + ++ + ++ + + +++ + + +L+ AK+F +
Sbjct: 4566 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4625
Query: 3809 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3868
L +W+ E ++ L E + + K QL+++K Q+++ + + G +L
Sbjct: 4626 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685
Query: 3869 LELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3928
E +L D D L+ D D L+ L+ K DT+ G+ + Q
Sbjct: 4686 KE---KTSLAD--DNLKLD-------------------DMLSELRDKWDTICGKSVER-Q 4720
Query: 3929 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 3988
KL++ + Q T D+ A+ R+ L + H D + A Q +L
Sbjct: 4721 NKLEEALLFSGQFT-DALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKEL 4778
Query: 3989 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLD--------LLCSMCDLSNASVKTTAKDI 4040
K+ +AL+ AR ++ + M +LS A I
Sbjct: 4779 G-------------KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4825
Query: 4041 QQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL--ELNIAQ 4098
+ + +E L QA EE + L +L +A+Q L R H L + + +
Sbjct: 4826 SK-QTRLEAALRQA-------EEFHSVVHALLEWLAEAEQTL----RFHGVLPDDEDALR 4873
Query: 4099 NMVSQVKDFVKKLQSKQASVN 4119
++ Q K+F+KKL+ K+A +N
Sbjct: 4874 TLIDQHKEFMKKLEEKRAELN 4894
Score = 264 bits (674), Expect = 3e-69
Identities = 856/4706 (18%), Positives = 1829/4706 (38%), Gaps = 694/4706 (14%)
Query: 2615 LLRMTKEKLRSCQVA--LQEHEALEEALQSMWFWVKAIQ---DR------LACAESTLGS 2663
L+++ K L+S + L E E + +Q + WV +Q DR L ES L +
Sbjct: 581 LMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN 640
Query: 2664 KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723
+ + + + + L E+++ + + +L L+ +A
Sbjct: 641 HKNVHRAIEEFESSLKEAKISEIQMTAPL--------------KLTYAEKLHRLESQYAK 686
Query: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWM-ESVDQKIEHPLQPQ-PGLKEKFVLLD 2781
++++S + + L+++ +++V R W+ E ++++ + + + K
Sbjct: 687 LLNTSRNQERHLDTL----HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 742
Query: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841
L L + E++ +++ + + L E + + ++TQ++ I+ + +
Sbjct: 743 ELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQTQWSWILQLCQ----C 796
Query: 2842 VEEIVKDHLMYLDAVH---EFTDWLHSAKEELHRWSDMSGDSSA------TQKKLSKIKE 2892
VE+ +K++ Y + + E TD+L + K+ + R SS Q+ + + +E
Sbjct: 797 VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 856
Query: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC-L 2951
L+ + A+ + + +++ +N S C L + D++Q E ++++ C L
Sbjct: 857 LLQYKSTIANLMGKAKTIIQLKPRN---SDCPLKTSIPIKAICDYRQIEITIYKDDECVL 913
Query: 2952 ENLVSQMALSEQEFSGQVAQL-----------EQALEQFSALLKTWAQQLTLLEGKNTDE 3000
N + +G A + ++A++ + + + + LTL + +
Sbjct: 914 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 973
Query: 3001 EIVECWHKGQEILDALQKAEPRT-------------EDLKSQLNELCRFSRDLSTYSGK- 3046
+ V WH +D ++ + + +L+S+ + S++ +SG
Sbjct: 974 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 1033
Query: 3047 VSGLIKEYNCLCLQ------ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDI 3100
++ L KE N +C Q S + +E+ + + R+ + L N + +
Sbjct: 1034 ITQLEKEVN-VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 1092
Query: 3101 PQNISEVSTSLQKIQE---FLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTA 3156
P ++ S+ +I E E E + L + +K E S +++++
Sbjct: 1093 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 1152
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT--EKMVHESSNRLYDLP 3214
++ +S L+ + + +K+ + + ++ + +K E+ V N + +L
Sbjct: 1153 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 1212
Query: 3215 AKRRE-QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN 3273
+ ++ + ++ + H E +L + K + +++ K+++ R
Sbjct: 1213 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF------KTYKERDLDFDWH------ 1260
Query: 3274 LTKEKVSRL-DRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3332
KEK +L +R H Q +++L+ + D+Y HP D
Sbjct: 1261 --KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY-HPLDDW------------ 1305
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3392
++Q + Q K +Q PE T+ QL K +L + I K
Sbjct: 1306 ---IQQVETTQRK---------IQENQPENSKTLATQLNQQK-----MLVSEIEMKQSKM 1348
Query: 3393 GALSKWTS-YQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS--- 3448
K+ Y V+ + + A ++ ++ + R M A L+ +E +
Sbjct: 1349 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR---RMQSSADLIIQEFMDLRT 1405
Query: 3449 -YSSL--LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505
Y++L L T +K AG + L+ L+E ++++E KE V K+++L +
Sbjct: 1406 RYTALVTLMTQYIKFAGDS--------LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1457
Query: 3506 RDLKAFEV---------------------WLGQEQEKLDQYSVLEGDAHTHETTLRDLQE 3544
+ LK E L + + + + GD T E ++
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517
Query: 3545 LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN-- 3602
++ L + L ++ SG + E++ + +Q+++ + + TQ N
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1577
Query: 3603 -------VVNKLRLMEQKFQQVDEWLKT---------AEEKKWHEEVTAYRDEVEEVGAR 3646
++ + +K+Q E L+ AE K E ++ E++
Sbjct: 1578 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL--KENGEKLSQE 1635
Query: 3647 AQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE-----IQSLEESESSLSS 3701
+ ++++ +++ C+ L + L + EE ++ LEES++ + +
Sbjct: 1636 DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIEN 1695
Query: 3702 YSDWYGSTHKNFKNVATKIDKV----------------------------DTVMMGKKLK 3733
DW + K+ + TK +V +T + G+
Sbjct: 1696 LLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGT 1755
Query: 3734 TLEVLLKDMEKGHS--------------LLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
T E L + +K + +SA+ E+ +YL E E+L+K +M
Sbjct: 1756 TQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----NM 1811
Query: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
++LK T E EK + L ++ L ++ A+Y E H ++ + EL +A
Sbjct: 1812 KELKVHYETALAES---EKKMKLTHSLQEE---LEKFDADYTEFEHWLQQSEQELENLEA 1865
Query: 3840 ----------QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQ 3889
+L + KS + V+SH+ ++ + G +LE + + +D
Sbjct: 1866 GADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD------GGKV 1919
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
D + + + ++ DR +L K + L D + + H + A
Sbjct: 1920 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK------YQHYE------DAS 1967
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4009
C + Q+ E KH+S + +Q LE + + + Q
Sbjct: 1968 CGLLAGL-QACEATASKHLSEPIAVDP-----KNLQRQLE---ETKALQGQISSQQVAVE 2018
Query: 4010 ALQEQARTYLDLLCSMCDLSNASVKTT----------AKDIQQTEQTIEQKLVQAQNLTQ 4059
L++ A LD S+ N KT +K + + + ++ L ++ ++
Sbjct: 2019 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2078
Query: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119
G +E+ + L++ Q L Q+++S+ + + +Q+S+N
Sbjct: 2079 GLDEMLDWMGNVESSLKEQGQV---------PLNSTALQDIISKNIMLEQDIAGRQSSIN 2129
Query: 4120 TIIEKVNKLTKKEE----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
+ EKV K + + S ++ L+ ++ + + + EE + + +
Sbjct: 2130 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 2189
Query: 4176 NVVEVFLEKFT---TEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232
++ FLE T TE D + E + E+ + E K +E L +++
Sbjct: 2190 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL----EHKKHLEVLHSLLKEIS 2245
Query: 4233 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4292
H DK LV E+T++L +++ ++ED IK K + + E+L+ Q + L W +E
Sbjct: 2246 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 2305
Query: 4293 -------QPNI-AEAL------------KQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
QP+ AE L K S Q + +++C+ + A K+
Sbjct: 2306 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2365
Query: 4333 L--IKDADRVM-------------ADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4377
+ +K V+ A+ GL I+K ++D L L+ + L
Sbjct: 2366 IAAVKSGGAVLNGEGTATNTEEFWANKGLTS---IKKDMTDISHGYEDLGLLLKDKIAEL 2422
Query: 4378 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD---VSKQVKTCKSAQASLKT 4434
N LS K Q A Q Q K + P D V QV+ KS +A LK
Sbjct: 2423 NTKLS-KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2481
Query: 4435 YQNEVTGLWAQGRELMKEVTE-QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493
N+V L + EL++E + E L E+ S + + Q R Q+LE++ +
Sbjct: 2482 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2541
Query: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ----SPEYENLLL 4549
F+ + WL + +++ L + + L+TQ + Q +L++ P+YE L
Sbjct: 2542 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2601
Query: 4550 T----LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4605
L R G+ PSL + + E+L A+ ++++ + D+ + +AI+ +Y
Sbjct: 2602 AGQGILSRPGED--PSLRGI----VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQY 2655
Query: 4606 ASLIELTTQSLSELEAQFLRMSKVPT-----DLAVEEALSLQDGCRAILDEVAGLGEAVD 4660
SL+ + LS+L+ + V T + +E A ++ + ++ +
Sbjct: 2656 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2715
Query: 4661 ELNQ-KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
+L+ KE + Q + +L + ++++ E V L+ ++ + ++M +
Sbjct: 2716 DLSALVKEEYLKAELSRQLEGIL---KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF 2772
Query: 4720 ERQLKSVKEEQSK---VNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD 4776
+ L + KEEQ+K ++ + E +K + + +L + ++ E+L L
Sbjct: 2773 QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL--LK 2830
Query: 4777 PLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID----FQTEMSRSLDWLRRV 4832
EKA Q+Q +K + V E E+++ +S++ ++ ++ W+ +
Sbjct: 2831 TQGSEKAALQLQ--LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2888
Query: 4833 KAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA---KELIS 4889
+ L + L+ + + I K++ Q+E+ ++ L++ + KE+++
Sbjct: 2889 QNNLE-EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2947
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 4949
D SL + ++ + E L +++ L + + + + +V + + L+ A+E L +
Sbjct: 2948 -DENKSLIQKVDM---VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH- 3002
Query: 4950 NGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL--DPLIKPT---GKEDLEQKV 5004
D ++ ++ T+ + L+ L L D +++ + G D+ +V
Sbjct: 3003 ---DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQV 3059
Query: 5005 ASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS 5064
++ +S+ + L+ +Q E+ + + +L + + +
Sbjct: 3060 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA- 3118
Query: 5065 HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ-------LEKTGNDASKATLSRSMTTV 5117
E L + K + E ++A + A++ E+T D + R + +
Sbjct: 3119 ----ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL--VGIKRDLEAL 3172
Query: 5118 WQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELL 5177
++ +L AQ +E+ +E + F +K+K+ + ++ + ++ ++ E
Sbjct: 3173 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGMETE 3229
Query: 5178 TLLEYHDTF-VLELEQQQSALGMLRQQTLSMLQDG---AAPTPGEEPPLMQEITAMQDRC 5233
T+ + + F V + E+ + G +QQ ++ L G +A L ++ + R
Sbjct: 3230 TINQQLNMFKVFQKEEIEPLQG--KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 3287
Query: 5234 LNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIE---IDAQLE 5287
+ +KV +++ L + + S+ W+ +T+E + N P+ E + AQ++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3347
Query: 5288 ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVA-LDLK---IRDQIQ 5343
E Q LL + R++ ++ + + EK T P++ L +++ LD + + ++ +
Sbjct: 3348 E-QKLLQRLLDDRKSTVEVIKREGEKI--ATTAEPADKVKILKQLSLLDSRWEALLNKAE 3404
Query: 5344 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKL------KAKTDNVVQAKTDQKVLGEE 5397
+ +++E +Q+ ++ L + LTTI +L + + + K L ++
Sbjct: 3405 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3464
Query: 5398 LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ-AENRLSKLNQAAS 5456
+ N L + + Q + + K + + +++ I++ + +R L QA
Sbjct: 3465 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC 3524
Query: 5457 HLEEYNEMLELILKW-------IEKAKVLAHGTIA-WNSASQLREQYILHQTLLEESKEI 5508
+ + + E ++ W + K V + T W S+LR +L + +L + +
Sbjct: 3525 NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNV 3581
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEA 5568
D L E L+ T +V + + E ++ K + D AK +++
Sbjct: 3582 DQALLNGLELLKQTT--------GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3633
Query: 5569 ELKKLQAALEQAQATLTSPEVGRLSLKEQL----------SHRQHLLSEMESLKPKVQAV 5618
++L + E+ L EV LS + Q+ + L E ++ K + ++
Sbjct: 3634 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3693
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM-- 5676
SAL A L E + T Q+ + AA+++ +Q++Q
Sbjct: 3694 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADA 3753
Query: 5677 ---------KHLQQLIEGAHREIEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQIAS 5726
K L L G R +D+ A +Q+ +I RH+++ + +I +
Sbjct: 3754 ELSWITETEKKLMSL--GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3811
Query: 5727 LNSKCKMLTMKAK--------------HATMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 5772
S+ + +MK K ++ L + + L + EL P +
Sbjct: 3812 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3871
Query: 5773 SVVMMTAGRC------------HTLL-------SPVTEESGEEGTNSEISSPP---ACRS 5810
S++ H L P ++ + G SP + +
Sbjct: 3872 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE 3931
Query: 5811 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLE-----PSATAK 5865
A+T S ++ +A++ + + + + H E E +E PS +A+
Sbjct: 3932 KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE 3991
Query: 5866 LGDLQRSWETLKNVI--SEKQRTLYEALERQ-----------------QKYQDSL----- 5901
+ ++ KNV EK + LYE L+++ + QD L
Sbjct: 3992 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 4051
Query: 5902 --QSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
++I T +E E KL + E E +H +L+ I QD I +L
Sbjct: 4052 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIKDTQDFIRDL---------- 4098
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN--DQLEEQRQEQALQRY 6017
E DP S + E TIR + G ++ L+ +N +L E
Sbjct: 4099 EDPGIDP-------SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 4151
Query: 6018 RCEADELDS-WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE----IEQKVVALSEL 6072
+ DEL+S W KA D + +E M Q D + + K+ ++S +
Sbjct: 4152 KKSIDELNSAWDSLNKAWKD-RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4210
Query: 6073 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6132
E + K + E+L +E++R H +L ++ +E ++
Sbjct: 4211 GTDLETV--------KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT-- 4260
Query: 6133 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 6192
VQ+ L + + W + + +Q +LE L + G+ QH+
Sbjct: 4261 --------VQDPLMELKLIWDSLEERIINRQHKLEGAL----------LALGQ---FQHA 4299
Query: 6193 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQN--VLEQEQ 6250
E +LS++ + G+ + E ++ K +LQN + Q
Sbjct: 4300 LDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL------------AKHHVLQNDVLAHQST 4347
Query: 6251 EQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIH 6307
+ + N L+ ++ S + + L+ LNQ ++ V ++ K+Q ++
Sbjct: 4348 VEAVNKAGNDLIE-------SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4400
Query: 6308 LEQKLYDGVSATSTWLDDVEERLFVATAL--LPEETETCL-FNQEILAK-DIKEMSEE-- 6361
+ + + WL D E L + L LPE + L + E+ A + KE + +
Sbjct: 4401 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4460
Query: 6362 MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6421
M K + + ++ P++ + I+ + L + +++ +N+R +++E L + F N
Sbjct: 4461 MQKGQQMLARC-PKSAETN--IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4517
Query: 6422 LKVLFTSLADNKYIILQKLANVFEQP------VAEQIEAIQQAEDGLKEFDAGIIELKRR 6475
L+ L ++ NV +P V QI+ + + + IIEL +
Sbjct: 4518 LQDFINWLTQ-----AEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4572
Query: 6476 GDKLQVEQPSMQE------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6529
G L+ L +Q +++++ + R L+ Q+ A L +
Sbjct: 4573 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4632
Query: 6530 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ--- 6586
LE EK + I + ++I+ L +HKE+ + L + + +T R S +
Sbjct: 4633 WLEE-SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691
Query: 6587 -----KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6641
K +EL + + ++ +R +LE L + Q L L VE +
Sbjct: 4692 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4751
Query: 6642 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQL 6698
V + D +++ I ++ + L + + Q L R LI S D ++ Q+
Sbjct: 4752 AEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELIEGSRDDSSWVKVQM 4810
Query: 6699 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 6758
+L W + + RLE L+ + S L+ WL A+ L F +P
Sbjct: 4811 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRF----HGVLP 4866
Query: 6759 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT-ATLRSELSRIDSQW 6817
+ + +R ++ EF K+++ + + + + G+ +L + D+ T++ ++ I +++
Sbjct: 4867 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARF 4926
Query: 6818 TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-QKDEDNIKNSIGYKAIH 6876
++L Q++L + + + +++W+ E + KD++ I I + +
Sbjct: 4927 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI--EEVK 4984
Query: 6877 EYLQKYKGFKIDINCKQLTVDFVNQS 6902
+ +++ F ++ KQ VD V ++
Sbjct: 4985 ALIAEHQTFMEEMTRKQPDVDKVTKT 5010
Score = 245 bits (626), Expect = 1e-63
Identities = 593/3347 (17%), Positives = 1290/3347 (38%), Gaps = 356/3347 (10%)
Query: 544 EQLLQNYVSF-IENSKFFEQYEVTYQILKQTAEMYVKADG---SVEEAENVMKFMNETTA 599
E L Q Y ++ K Q++ I Q+A++ ++ G S EE E + K M E
Sbjct: 1758 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816
Query: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH 659
+ E + + +++ + WL+ +E+ L E D +
Sbjct: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876
Query: 660 WIQQHTAMND-------------AGNFLIETCDEMVSRD------------LKQQLLLLN 694
+Q + D +GN ++E RD ++++L
Sbjct: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1936
Query: 695 GRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNV 749
R+R L+ + D+ + + L A A K LSEP+ V N+
Sbjct: 1937 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 1996
Query: 750 KLLIQDLEDIEQRVPVMDAQYKIITKTAHLI---------------------------TK 782
+ +++ + ++ ++ + + KTA ++
Sbjct: 1997 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 2056
Query: 783 ESPQEEGKEMFATMSK-------LKEQLTKVKECYSPLLYESQQLLIPLEE--------- 826
+S E +++ T+++ L E L + S L + Q +PL
Sbjct: 2057 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ---VPLNSTALQDIISK 2113
Query: 827 ---LEKQMTSFYDSLGKINEII-------------TVLEREAQSSALFKQ---KHQELLA 867
LE+ + S+ +NE + ++ + SA F + KH+E LA
Sbjct: 2114 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 2173
Query: 868 CQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWK 926
E K + L E S+ +Q F+ T + L D + + ++ Q + + K
Sbjct: 2174 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP--GKDVTELSQYMQESTSEFLEHK 2231
Query: 927 KHVETNSRLMKKF------EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQ- 979
KH+E L+K+ + LEK ++++ E + +E T QLD
Sbjct: 2232 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 2291
Query: 980 RVLNAFLKA-CDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRF 1038
+VL LK+ E T +P + E + K + K LQ + ++
Sbjct: 2292 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2351
Query: 1039 LASVEECRTELDRETKLMPQEGS----EKIIKEHRVFFSDKGPHHLCEKRLQL---IEEL 1091
L ++ T + + G+ E F+++KG + + + E+L
Sbjct: 2352 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2411
Query: 1092 CVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1151
+ L + +T + +E +A+ +K+ + KW+ + + + T
Sbjct: 2412 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD--TEAVKTQV 2469
Query: 1152 TQLKGIKGEAIDTANH-GEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQ 1210
Q K + E N E+K + E+ E W ++LTE+ S+ + Q
Sbjct: 2470 EQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW----KQMLTEIDSKWQELNQ 2525
Query: 1211 --GDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEK 1268
D KL S L T VE L + + KE++ + L L + Q ++
Sbjct: 2526 LTIDRQQKLEESSNNL-TQFQTVEAQLKQW---LVEKELMVSVLGPLSIDPNMLNTQRQQ 2581
Query: 1269 ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD-----RG--HEEL 1321
+ Q+LL A ++ +Q+ A QG P RG E+L
Sbjct: 2582 V----------QILLQE-------FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2624
Query: 1322 RKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL-- 1379
+ D L + I + K T ++++R L S + LS SSL
Sbjct: 2625 AAVTQKWDSLTGQLSDRCDWIDQAIVK----STQYQSLLRSLSDKLSDLDNKLS-SSLAV 2679
Query: 1380 ----ESLSSELEQTKEFSKRTESIAVQ---AENLVKEASEIPLGPQNKQLLQQQAKSIKE 1432
++++ +LE ++ + + Q A+ L ++ S + K L +Q + I +
Sbjct: 2680 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2739
Query: 1433 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1492
K +E E ++ ++ F W+ K++E N S+ +D+ S
Sbjct: 2740 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2799
Query: 1493 IKVTIQEIESKLSSIVGLEE----EAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQ 1548
IK ++ L++ + E E ++ E A ++ +L I+ + + +
Sbjct: 2800 IK-DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVK 2858
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATE------TYKVLQEH 1602
E + L + K++E + + + + ++ L IK C E K LQ+
Sbjct: 2859 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKLKSLQKE 2917
Query: 1603 MDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLA 1662
MD + L + TA S + ++++ E +L Q+ + + + ++ LEN+
Sbjct: 2918 MDQHFGMVELLNN-TANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQ 2976
Query: 1663 HWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK 1722
++ ++ +K S ++ + +++ + L QA N+ ++ K
Sbjct: 2977 KFKEFQE------------VSKESKRQLQCAKEQLDIHDSLG-SQAYSNKYLTMLQTQQK 3023
Query: 1723 LLQ------------LKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSV 1770
LQ ++ + + + L +E + + L Q ++++ +FL++
Sbjct: 3024 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 3083
Query: 1771 VAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSL 1830
+ F + F EL + + + + A T K + E+ K L+ L
Sbjct: 3084 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVG----RDAETLQK----QKETIKAFLKKL 3135
Query: 1831 QGHLAKLGSLGRAEDLHL--------LQGKAEDCFQLFEEASQVVERRQL-------ALS 1875
+ +A + + + L L G D L ++ +++++R Q +
Sbjct: 3136 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIK 3195
Query: 1876 HLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDG 1935
L EF S +L++ + E+ + E++ I + LN K ++
Sbjct: 3196 RLEEFYSKLKEFSILLQKAEEHEESQGPVGM-ETETINQQLNMFKVFQKE------EIEP 3248
Query: 1936 ILSKAQYHLKIGSSEQRTSCRATADQ-LCGEVERIQNLLGT-KQSEADALAVLKKA---- 1989
+ K Q +G +++ ++T+ Q L +++ + T + A A L++A
Sbjct: 3249 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 3308
Query: 1990 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2047
FQD E LL + D EE ++ + ++ +++ L+ L+ + + +K
Sbjct: 3309 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3368
Query: 2048 KAKQIA-QKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVS 2106
+ ++IA + A ++ ++++ L+ W+ Q G+ + +++ ++
Sbjct: 3369 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3428
Query: 2107 KVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKK 2165
+ L +V I Q L+ ++H+ ++ + K L S G+ L K
Sbjct: 3429 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-----K 3483
Query: 2166 IHSS--DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE--GWSN 2221
+ SS D +V++ ++ + ++++ EK + L+ +L + + DE+E W N
Sbjct: 3484 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLN 3541
Query: 2222 NCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLE----T 2277
++ + +S L + E L + +SE+ + L+ + L K N + L LE T
Sbjct: 3542 ----EVHDKLSKLSVQDYSTEGLWKQQSEL--RVLQEDILLRKQNVDQALLNGLELLKQT 3595
Query: 2278 PPDLQFIEADLMQKL-----EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2332
D I D ++ + + K T+VAK TL+ + ++ ++ TW KVE
Sbjct: 3596 TGDEVLIIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTHEELCTWLDKVEV 3654
Query: 2333 SLMN-----CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGR 2387
L++ E +A + K+++KE ++ ++ + S E ++L E L +
Sbjct: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3714
Query: 2388 AMTGLIKKHEAVSQLCSKTQASLQESL--EKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
+ +++ VS ++ + ++ + F ++ W + D +
Sbjct: 3715 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3774
Query: 2446 SKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQA 2505
A+L + + + +D + + G + S++ S+++++ K + +
Sbjct: 3775 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3834
Query: 2506 FLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2565
+ + L+ S + F + + +L W+ E + + + ++ E H
Sbjct: 3835 ICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEH 3894
Query: 2566 KVEMFLGELLAA-RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLR 2624
+ L EL+A + +DK+++ G L E G EG + + L KE ++
Sbjct: 3895 RQ---LRELIAEHKPHIDKMNKTGPQLLELSPG---EGFSIQEKYVAADTLYSQIKEDVK 3948
Query: 2625 SCQVALQE--------HEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
VAL E H+ +++ L+S+ + I +RL S + +++++S+ ++
Sbjct: 3949 KRAVALDEAISQSTQFHDKIDQILESL----ERIVERLRQPPSISAEVEKIKEQISENKN 4004
Query: 2677 ILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ----RVIQTQLETLKEVWADIMSSSVHAQ 2732
+ + + + +GE+ + S + + +Q +L+ + +W +I + +
Sbjct: 4005 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064
Query: 2733 STLESVISQ----WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
+ L V+ W D++ ++ + + + + P +++ + ++I
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQ----EAAETIRE 4120
Query: 2789 EAEDHTRALHRLIAKSRELYEK--TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIV 2846
E + L +I EL D+ + +EL + ++ + K+++ K+EE +
Sbjct: 4121 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 4180
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELID---SREIGASR 2903
+ + Y D + DW+ A +L S + D ++++ ++K+ ++I R
Sbjct: 4181 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 4240
Query: 2904 LSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2963
L+ L +K+ T S + + L+ W E+ + Q LE + +
Sbjct: 4241 LNHQAELL--LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL----- 4293
Query: 2964 EFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3023
Q + AL++ A L L+ + D + +E +L A T
Sbjct: 4294 ------GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4347
Query: 3024 -EDLKSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRK 3078
E + N+L S + S K+ L + + + + + Q + L+Q F
Sbjct: 4348 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4407
Query: 3079 AFRDFQQWLVNAK---ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3135
D QQWL + + + + +P+ E L E + E + ++ KG
Sbjct: 4408 EIEDLQQWLTDTERHLLASKPLGGLPETAKE---QLNVHMEVCAAFEAKEETYKSLMQKG 4464
Query: 3136 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3195
+ + K I + KE W++ + L+++++ LE +F S + +W
Sbjct: 4465 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4524
Query: 3196 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL--WEGQAA 3253
L++ E+ ++ +S L + + + E++ + Q+ L + L + +
Sbjct: 4525 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4584
Query: 3254 SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY 3313
++ + + S++ + E+ LD QF +L +W+ ++ LDS
Sbjct: 4585 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4644
Query: 3314 CHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS-PEGIPTIQQQLQS 3372
+D + ++ + + K G S+ + TS + + L
Sbjct: 4645 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4704
Query: 3373 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3432
++D W ++ + +++LE AL + D ++ W+ +E L E + H ++
Sbjct: 4705 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4764
Query: 3433 TTMLGKAKLLNEEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQER 3486
++ K +E+ +S ++ ++ ++G+ +V ++++Q+L R+ +
Sbjct: 4765 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV-KVQMQELSTRWETVCAL 4823
Query: 3487 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3546
+ T+ E +R +E+ + A WL + ++ L + VL D T + +E
Sbjct: 4824 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4883
Query: 3547 VHCAEGQALLNSVLHTREDVI----PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
E +A LN + V+ P I + + +R ++ + + + +
Sbjct: 4884 KKLEEKRAELNKATTMGDTVLAICHPDSITTIK-HWITIIRARFEEVLAWAKQHQQRLAS 4942
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQE 3649
+ L ++ + + WL+ AE ++ E+EEV A E
Sbjct: 4943 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 4989
Score = 239 bits (611), Expect = 7e-62
Identities = 867/4747 (18%), Positives = 1760/4747 (37%), Gaps = 818/4747 (17%)
Query: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2242
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 591 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 646
Query: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2299
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 647 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 692
Query: 2300 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2355
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 693 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 747
Query: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 748 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 798
Query: 2416 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2463
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 799 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 857
Query: 2464 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2502
+S + + + +T+ + +I ++ AN
Sbjct: 858 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 917
Query: 2503 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2542
+A K C ++ E Q++ L LW HE
Sbjct: 918 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 976
Query: 2543 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2592
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 977 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 1030
Query: 2593 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 1031 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 1083
Query: 2652 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2702
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 1084 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 1142
Query: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2762
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 1143 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 1197
Query: 2763 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2821
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 1198 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 1253
Query: 2822 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 1254 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 1313
Query: 2871 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2929
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 1314 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1371
Query: 2930 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2989
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1372 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1417
Query: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1418 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1458
Query: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1459 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1512
Query: 3110 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3156
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1513 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1572
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3210
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1573 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1632
Query: 3211 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3258
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1633 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1687
Query: 3259 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3308
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1688 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1747
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3363
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1804
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1805 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1864
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3465
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1865 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1924
Query: 3466 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3518
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1925 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984
Query: 3519 ------------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALL----NSVLHT 3562
Q +L++ L+G + + + L++ + + L N + T
Sbjct: 1985 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2044
Query: 3563 REDVI------PSGIPQAEDRALESLRQ------------DWQA-------YQHRLSETR 3597
+D++ + + ++ +L + DW Q ++
Sbjct: 2045 LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNS 2104
Query: 3598 TQFNNVVNKLRLMEQ-------KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEI 3650
T ++++K ++EQ ++E +K E ++ + +++++ AR E
Sbjct: 2105 TALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE- 2163
Query: 3651 LDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH 3710
SH + + +L ++ +E + L E++Q+ E+++ + D G
Sbjct: 2164 --ASHKHKETLAKMEELKTK--------VELFENLSEKLQTFLETKTQALTEVDVPG--- 2210
Query: 3711 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770
K+ ++ + + + + K K LEVL HSLLK G + K L +
Sbjct: 2211 KDVTELSQYMQESTSEFLEHK-KHLEVL-------HSLLKEISSHGLPSDKALVLEKTNN 2262
Query: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
L K + KE+ T++++ + F K+L WI E + + + +P
Sbjct: 2263 LSK-------KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQP 2314
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK-IDQLQSDYQ 3889
+ L K LQ+ P ++ V G +L L+ VT K I ++S
Sbjct: 2315 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2374
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
L G A E L +++ K T I + L LK +
Sbjct: 2375 VLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI-------------- 2419
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL-----SAVQPDLEPSPQPPLSRAEAIKQ 4004
L +L K Q+ WL +A + P+P + ++Q
Sbjct: 2420 --------AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2471
Query: 4005 VKHFRA-LQEQARTYLDLLCSMCDLSNASVKT-TAKDIQQTEQTIEQKLVQAQNLTQGWE 4062
K F A L++ +L + +L + T A +Q I+ K W+
Sbjct: 2472 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK----------WQ 2521
Query: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELE---------------LNIAQNMVSQVKDF 4107
E+ L + L+++ L + ++L+ L+I NM++ +
Sbjct: 2522 ELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2581
Query: 4108 VKKLQSKQASVNTIIEKVNK-----LTKKEESPE-----HKEINHLNDQWLDLCRQSNNL 4157
V+ L + A+ E++ L++ E P +++ + +W L Q ++
Sbjct: 2582 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2641
Query: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER 4217
C ++ + ++ Y + + +K + + L+ S A ST H +A+ + Q+
Sbjct: 2642 CDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVST--HPDAMNQQLETAQKM 2696
Query: 4218 KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK------RKIQVSVTN 4271
K I+ K Q K+ + L D LVKE+ E QLE ++K +K + V +
Sbjct: 2697 KQEIQQEKKQ-IKVAQALCEDLSALVKEEYLKAELS-RQLEGILKSFKDVEQKAENHVQH 2754
Query: 4272 LEELNVVQSRFQEL----MEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327
L+ +FQ++ W + ++ ++ S D+ ++L+ DH L A+
Sbjct: 2755 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS 2814
Query: 4328 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR----RKYLNKALSE 4383
+ + I + + ++ +E+ +Q L+ +++ + + V +R ++ L KAL
Sbjct: 2815 HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY 2874
Query: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443
K Q + ++ + Q + +I F CL P + + KS Q + + V L
Sbjct: 2875 KEQ-VETLWPWIDKCQNNLEEIKF----CLDPAEGENSIAKLKSLQKEMDQHFGMVELLN 2929
Query: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
L+ V E +K V + + L D V ++ + LE K F+E ++
Sbjct: 2930 NTANSLL-SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 2988
Query: 4504 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563
L+ A E ++H L S Y N LT+ +T Q
Sbjct: 2989 KRQLQCA-----------KEQLDIHDSLG--------SQAYSNKYLTMLQTQQ------- 3022
Query: 4564 EVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEA-----ILAR-----KEYASLIELTT 4613
+ L AL Q ++ LA+D + ++ +L + +E+++L +
Sbjct: 3023 --------KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 3074
Query: 4614 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR--- 4670
+ S LE + + + E S LD +A +G + L ++KE +
Sbjct: 3075 EKCSFLETKLQGIGHFQN--TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 3132
Query: 4671 --------STGQPWQPDKML--------HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK 4714
S + KM+ LV + L+ ++Q LL+ + ++ E
Sbjct: 3133 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 3192
Query: 4715 MCQQLERQLKSVK-------------EEQSKVNEETLPAEEKLKMY--------HSLAGS 4753
++LE +K E Q V ET ++L M+ L G
Sbjct: 3193 TIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 3252
Query: 4754 LQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMV 4813
QD + + + ++ A E H + K L + + + + ++
Sbjct: 3253 QQDVNWLGQGL---IQSAAKSTSTQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALL 3306
Query: 4814 QSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL 4873
FQ + L W+ + ++ + ++ +I++ ++ Q + + +
Sbjct: 3307 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3366
Query: 4874 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQV 4930
+E EK E AD L +LS LD + L TR L I Q++++
Sbjct: 3367 K-REGEKIATTAE--PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3423
Query: 4931 FQAANDWLEDAQE-LLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 4989
+ N+WL ++ L+ G EE + H + ED ++ + LH V+
Sbjct: 3424 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQ 3480
Query: 4990 PLIKPTGKEDLEQKVASLELRSQ---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5046
L + +ED + + L+ + S ++ +LLQ+ + + E++ +
Sbjct: 3481 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3540
Query: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
N+ KLS+ S ++ S+ ++ SE + L E I+ ++ Q G +
Sbjct: 3541 NEVHDKLSKLS-VQDYSTEGLWKQQSELRVL-------QEDILLRKQNVDQALLNGLELL 3592
Query: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
K T + + + ++A +D K+ D V K E QL +L
Sbjct: 3593 KQTTGDEVLIIQDKLEAIKARYKDITKLSTD-----------VAKTLEQALQLARRL--- 3638
Query: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
++ EL T L+ + +L E Q GEE
Sbjct: 3639 ---HSTHEELCTWLDKVEVELLSYETQ--------------------VLKGEE------- 3668
Query: 5227 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQL 5286
+ + K +K+E K+ + + +N E+ + L
Sbjct: 3669 ----------ASQAQMRPKELKKEAKNNKALLDSLN------------------EVSSAL 3700
Query: 5287 EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKI 5346
EL R+ +EKM E E+Y L S+ Q E +R Q D+
Sbjct: 3701 LEL-----VPWRAREGLEKMVAEDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQA 3750
Query: 5347 KEVEQSKATSQE---LSRQIQKLAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCN 5402
+ E S T E +S +L +D T+ L K T +++ K + ++L
Sbjct: 3751 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSG 3806
Query: 5403 SKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN 5462
K+M + +K + + KK+ K+ + + + R +L +A S + ++
Sbjct: 3807 HKIMTACSEEEK---------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3857
Query: 5463 EMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521
E E + W+ E +++ LR+Q H+ L E E ++ M +
Sbjct: 3858 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3917
Query: 5522 LTSVYCTEKMSQQVAELGRET--EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
L + E S Q + +T ++++ +K R L +A +F ++ ++ +LE+
Sbjct: 3918 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 3977
Query: 5580 AQATLTSP-----EVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA- 5633
L P EV + +KEQ+S +++ +ME L+P L ++ + E+++A
Sbjct: 3978 IVERLRQPPSISAEVEK--IKEQISENKNVSVDMEKLQP------LYETLKQRGEEMIAR 4029
Query: 5634 --SLPLCHAALRLQEEASRLQ------HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIE 5684
+A +Q++ ++ HT +++ V++ E++ + L I+
Sbjct: 4030 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4089
Query: 5685 GAH---REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
R++ED + S +++ Q E + ++I G QE++ + + L
Sbjct: 4090 DTQDFIRDLEDPGIDPSVVKQQQ---EAAETIREEIDGLQEELDIVINLGSELIAACGEP 4146
Query: 5742 TMLLTVTEVEGLAEGTEDLD----GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797
+ ++ L + L+ + A + V G + V G+
Sbjct: 4147 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK-- 4203
Query: 5798 TNSEISSPPACRSPSPVANTDASVNQDI---------AYYQALSAERLQTDAAKIHPSTS 5848
S SP+ +V Q I AY Q + ERL H +
Sbjct: 4204 ----------LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN------HQAEL 4247
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
++ E + + L +L+ W++L+ I +Q L AL ++Q +L + +
Sbjct: 4248 LLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4307
Query: 5909 EAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
E LSE G P E ++A+H L +++L Q + E + +L+ S +
Sbjct: 4308 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEE 4366
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ+ L VL +R + K ++Q L+ L RQ + + E ++L
Sbjct: 4367 ASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQ 4413
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL T+ L + P + QL + E K L + +L
Sbjct: 4414 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4473
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQ 6142
+ +Q + LK ++ L++++ ++ A E S D
Sbjct: 4474 SAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI-------- 4522
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE 6202
WL QA T + SL L Q + E K V S E+I+ +
Sbjct: 4523 NWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4581
Query: 6203 KPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL 6262
K DV+ + + ++ +WE + Q + + L + ++ ++ + ++L+
Sbjct: 4582 KQDVVLIK--------NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLM 4631
Query: 6263 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATS 6320
+ + + ++ S L+ N +++ +Q K ++S+ + +YD + T
Sbjct: 4632 EWL--------EESEKSLDSELEIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4682
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
L E+T LA D ++ + + + ++ + ++ + +
Sbjct: 4683 --------------RSLKEKTS--------LADDNLKLDDMLSELRDKWDTICGKSVERQ 4720
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ +E+ L G+ + + ++++ +L + D+ ++ + ++K
Sbjct: 4721 NKLEEAL-LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHK------- 4772
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
F++ + ++ ++Q + +E G R D V + MQELS ++ +
Sbjct: 4773 --AFQKELGKRTSSVQALKRSARELIEG-----SRDDSSWV-KVQMQELS---TRWETVC 4821
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHK 6560
+ S+++ L L ++ + L + L ++ + ++ ++ ++ L+D+HK
Sbjct: 4822 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHK 4880
Query: 6561 EYFQGLE 6567
E+ + LE
Sbjct: 4881 EFMKKLE 4887
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 507 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 558
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2414 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2473
Query: 559 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 614
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2474 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2533
Query: 615 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 661
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2534 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2593
Query: 662 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 718
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2594 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2653
Query: 719 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 768
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2654 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2713
Query: 769 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 821
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2714 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2773
Query: 822 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 878
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2774 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2829
Query: 879 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 938
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2830 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2887
Query: 939 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 996
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2888 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2946
Query: 997 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1053
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2947 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 3003
Query: 1054 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1113
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 3004 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 3058
Query: 1114 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1171
E A ST + +++ + + + F + I +Q E A G
Sbjct: 3059 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 3118
Query: 1172 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1231
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 3119 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 3169
Query: 1232 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1272
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 3170 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 3228
Query: 1273 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1328
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 3229 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 3287
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1386
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 3288 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3346
Query: 1387 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1444
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3347 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3406
Query: 1445 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1501
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3407 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3466
Query: 1502 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1561
+ + QS + + +++KL + + E++E + + L
Sbjct: 3467 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3526
Query: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1614
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3527 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3583
Query: 1615 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1672
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3584 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3643
Query: 1673 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1732
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3644 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3702
Query: 1733 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3703 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3762
Query: 1793 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3763 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3822
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3823 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3881
Query: 1907 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1964
E + + + + Q + + +D + L++ E AD L
Sbjct: 3882 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3941
Query: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2024
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3942 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3998
Query: 2025 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2078
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 4057
Query: 2079 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2128
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 4058 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 4108
Query: 2129 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2184
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 4109 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 4168
Query: 2185 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2244
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 4169 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 4224
Query: 2245 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2301
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 4225 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 4281
Query: 2302 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2356
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 4282 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
Query: 2357 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2415
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
Query: 2416 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4402 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4461
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4521
Query: 2535 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2594
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4522 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4577
Query: 2595 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2650
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4637
Query: 2651 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2709
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4638 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4697
Query: 2710 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2769
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4698 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4757
Query: 2770 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2828
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4758 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4817
Query: 2829 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2888
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4818 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4877
Query: 2889 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2948
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4934
Query: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4935 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 4977
Query: 3009 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3054
QEI E++K+ + E F +++ V + K Y
Sbjct: 4978 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 5011
Score = 206 bits (525), Expect = 6e-52
Identities = 145/440 (32%), Positives = 223/440 (50%), Gaps = 72/440 (16%)
Query: 16 NVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKL 75
+V++R +DE++ VQK+TFTKWIN HL K + V+DL+ED++DG L++LLEVLSG L
Sbjct: 24 DVLERYKDERDKVQKKTFTKWINQHLMKVRKH--VNDLYEDLRDGHNLISLLEVLSGDTL 81
Query: 76 PCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWT 135
P E+GR R H + N+ AL +L+ R+ +KLVNI + DI DG P + LGL+WT
Sbjct: 82 PREKGRM--RFHRLQNVQIALDYLKRRQ-------VKLVNIRNDDITDGNPKLTLGLIWT 132
Query: 136 IILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWV 195
IIL+FQI ++ V+ E+ +AK+ LL W
Sbjct: 133 IILHFQISDIH-------------------VTGESEDM------------SAKERLLLWT 161
Query: 196 QYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 255
Q GI ++F WR G F+++IH RP+L+D+ TV +SN NLE AF +AE
Sbjct: 162 QQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE- 220
Query: 256 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANS 315
++G+ RLLDPEDVDV PDEKS++TYV+ +P + +G +++ + + N
Sbjct: 221 KIGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGG-EGIGANDVEVKWIEYQNM 279
Query: 316 VQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRV----QYEMKRKQ 371
V + R M ER + L ++Y FK + + K K+
Sbjct: 280 VNYLIQWIRHHVTTMS------ERTFPNNPVELKALYNQYLQFKETEIPPKETEKSKIKR 333
Query: 372 IEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 431
+ L++ G++ L Q ++ +W G + + E A
Sbjct: 334 LYKLLEIWIEFGRIKLLQGYHPNDIEK------EW------------GKLIIAMLEREKA 375
Query: 432 LREEITVQQVHEETANTIQR 451
LR E+ ++ ++ AN +QR
Sbjct: 376 LRPEVERLEMLQQIANRVQR 395
Score = 170 bits (430), Expect = 7e-41
Identities = 619/3344 (18%), Positives = 1264/3344 (37%), Gaps = 595/3344 (17%)
Query: 5604 LLSEMESLKPKVQAVQLCQS-ALRIPED-VVASLPLCHAALRLQEEASRLQHTAIQQCNI 5661
+L ++L+P+V+ +++ Q A R+ D V+ L A LQ ++ RL+ + +Q N
Sbjct: 369 MLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLE-SGVQFQNE 427
Query: 5662 MQAA--VVQYEQY-EQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIK 5718
+ A +++ E Q + +Q LI+G + + + +L Q++
Sbjct: 428 AEIAGYILECENLLRQHVIDVQILIDGKYYQAD--------------------QLVQRVA 467
Query: 5719 GYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEG-------------TEDLDGELL 5765
+++I +L ++C + K + T T + G+ + T L L
Sbjct: 468 KLRDEIMALRNECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLT 527
Query: 5766 PTPSAHPSVVMMTAGRCHTLLSPVTE--------------ESGEEGTNSEISSPPACRSP 5811
P+ ++ +++G L VT SG E + + R P
Sbjct: 528 PSLTSSSMTSGLSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKP 587
Query: 5812 SPVAN------TDASVN----QDIAYY---QALSAERLQ--TDAAKI------HPSTSAS 5850
++ T+ +N QD+ + + +R + +D + H + +
Sbjct: 588 LLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA 647
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTL---YEAL----ERQQKYQDSLQS 5903
E +E L+ AK+ ++Q + LK +EK L Y L Q+++ D+L +
Sbjct: 648 IEEFESSLKE---AKISEIQMT-APLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN 703
Query: 5904 ISTKM--EAIELKLSESPEPGRSPESQMAE-------HQALMDEILMLQDEINELQSSLA 5954
++ E I L E E + H LM E+ ++ I +Q +A
Sbjct: 704 FVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQE-IA 762
Query: 5955 EELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEK------LNDQLEE- 6007
E+L+ E+ A +L +++ + + S I Q ++E ND E
Sbjct: 763 EQLLLENHPA----RLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEAT 818
Query: 6008 ---QRQEQALQR-YRC--------------EADELDSWLLSTKATLDTALSPPKEPMDME 6049
+ + A+QR Y C E+ E LL K+T+ + K + ++
Sbjct: 819 DYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLK 878
Query: 6050 AQLMDCQNMLVEIEQKVVA---LSELSVHNEN-LLLEGKAHT------------------ 6087
+ DC + I K + E++++ ++ +L +H
Sbjct: 879 PRNSDCP-LKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 937
Query: 6088 -------KDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ---------EKEESDV 6131
EA LA ++ + ++L L H+ +NM+ S+V
Sbjct: 938 CFTVPPPNKEAVDLANRIEQQYQNVLTLW---HESHINMKSVVSWHYLINEIDRIRASNV 994
Query: 6132 DLTATQSPGV-QEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQ 6190
T PG Q+ L+ ++ + + S + Q ++ + + + +E+L
Sbjct: 995 ASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKS 1054
Query: 6191 HSAAETSGDAGEK--PDVLSQELGMEGEKSSAEDQMR--MKWESLHQEFS--TKQKLLQN 6244
E +V + L +E + Q+R ++ + LH+ T+Q+ L+
Sbjct: 1055 AEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKK 1114
Query: 6245 VLEQEQEQV--LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 6302
LE+ ++ + + ++ S VPT +S + +L +NQ + S+ K
Sbjct: 1115 ELERLKDDLGTITNKCEEFFSQAAA-SSSVPTL-RSELNVVLQNMNQVYSMSSTYIDKLK 1172
Query: 6303 RQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEM 6362
++ L+ A + E +L A++ ++ N E L +K+ E+
Sbjct: 1173 TVNLVLKN-----TQAAEALVKLYETKLCEEEAVIADKN-----NIENLISTLKQWRSEV 1222
Query: 6363 DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQ----QILNF 6418
D+ + +F A + I D + L ++ Q+ ER Q QI N
Sbjct: 1223 DEKRQVF-HALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNR 1281
Query: 6419 QNDLKVLFTSLADNKYI--ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRG 6476
DL+ + SL KY L + +Q Q + + + K + + K
Sbjct: 1282 LRDLEGIGKSL---KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLV 1338
Query: 6477 DKLQVEQPSMQELSKLQDMYDELMM-----------IIGSRRSGLNQNLTLKSQYERALQ 6525
+++++Q M E K + Y + ++ S++ + ++S + +Q
Sbjct: 1339 SEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQ 1398
Query: 6526 DLADL---------LETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ DL L T K AGD + +EE + L ++ KE+ +
Sbjct: 1399 EFMDLRTRYTALVTLMTQYIKFAGDS--LKRLEEEEKSLEEEKKEHVEKA---------- 1446
Query: 6577 FRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEV 6636
KE Q + ++ S LK A K G +S +E+S + E
Sbjct: 1447 ----------KELQ---KWVSNISKTLKDAEKAGKP------PFSKQKISSEEISTKKEQ 1487
Query: 6637 VESSIPSVGL-VEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLE 6695
+ ++ ++ L + ++ D++ D NE + K + L + LL S S
Sbjct: 1488 LSEALQTIQLFLAKHGDKMTDE---------ERNELE-KQVKTLQESYNLLFSES----- 1532
Query: 6696 SQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSV 6755
L QL E S K+ +++ + + Y+ + + L ++RL Q++
Sbjct: 1533 --LKQLQESQTSGDVKVEEKI-----VAERQQEYKEKLQGICDLLTQTENRL-IGHQEAF 1584
Query: 6756 TVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-----LKKVDTATLRSEL 6810
+ ++ + + E K++ + + V+ L+ L + D A + +L
Sbjct: 1585 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1644
Query: 6811 SRIDSQWTDLLTNIPAVQEKLHQLQMDKL-------------------PSRHAISEVMSW 6851
+ + L N+ A Q K ++DK+ S+ I ++ W
Sbjct: 1645 NEAKIKCEQL--NLKAEQSKK---ELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDW 1699
Query: 6852 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYK---GFKIDINCKQLTVDFVNQ--SVLQI 6906
+S ++ ++ K I H K G + ++N L D Q + +
Sbjct: 1700 LSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQEN 1759
Query: 6907 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTW 6966
+Q + ++ Q A+ + Q Q L+ ++ Q L E + + N++ LK
Sbjct: 1760 LNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP--EEKEKLQKNMKELKVH 1817
Query: 6967 FET----QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLAL 7017
+ET EK++K H + ++ +A D + E ++ E+E+E +E NGL
Sbjct: 1818 YETALAESEKKMKLTHSLQEELEKFDA--DYTEFEHWLQQSEQELENLEAGADDINGLMT 1875
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLK---SVLDQWSSHKVAFDKINSY 7074
+++ S V+S +L + + ++ K K +D ++H+ K++
Sbjct: 1876 KLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD-- 1933
Query: 7075 LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPV 7134
++ RFR L + +NL++L D + E + G + L+ C
Sbjct: 1934 -----HATDRFRSLYSKCNVLG---NNLKDLVDKYQHYEDA--SCGLLAG--LQACEATA 1981
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7194
++ L+ + + + QL+ +KAL + Q+ +L
Sbjct: 1982 SKHLSEPIAVDP-------KNLQRQLEETKAL--------------QGQISSQQVAVEKL 2020
Query: 7195 LKAATNKDIADDEVATWIQDCNDLLKGL----GTVKDSLFFLHELGEQLKQQVDASAASA 7250
K A ++ D + + ND+ K L G +D ++E E+L
Sbjct: 2021 KKTA---EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL----------- 2066
Query: 7251 IQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEIL--QGQD 7308
Q++L++ L S+Q G L+ + W+ E L QGQ
Sbjct: 2067 ----QITLTRSL------------SVQDG----------LDEMLDWMGNVESSLKEQGQV 2100
Query: 7309 PSHSSDLSTIQERM----EELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNR 7364
P +S+ L I + +++ G+ ++M + + E + + K M++L+
Sbjct: 2101 PLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK-MKDLSA 2159
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTF---LEKCETWMEFLVQTEQKLAVEISGNYQHLLE 7421
+S S + E +K++ + + F EK +T++E +T+ V++ G L
Sbjct: 2160 RFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLE--TKTQALTEVDVPGKDVTELS 2217
Query: 7422 QQRAHELFQ-AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRA 7480
Q + E ++LHS++ + + G D+ K LS +++ +
Sbjct: 2218 QYMQESTSEFLEHKKHLEVLHSLL---KEISSHGLPSDKALVLEKTNNLSKKFKEMEDTI 2274
Query: 7481 QQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS-----YLPMSGLGSVPIPLQQARTLFDE 7535
++++ + S Q ++ + + L+ W+ E + P G + L+ + L ++
Sbjct: 2275 KEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEK 2334
Query: 7536 VQFKEKVFLRQQGSYI-------LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASM 7588
K + S I K + GA + +E W A+
Sbjct: 2335 WSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFW--ANK 2392
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
L KK + + +E + D + +L T KL ++ EE A +++
Sbjct: 2393 GLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKA----QEESSAMMQWLQKMNK 2448
Query: 7649 AVGSW------TD--------------------DLTQLSLLKDTLSAYISAD----DISI 7678
W TD ++ ++ LKD L+ + + +
Sbjct: 2449 TATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPR 2508
Query: 7679 LNERVELLQRQWEELCHQLSLRRQQ-IGERLNEWAVFSEKNKELCEWLTQMESKVSQNGD 7737
+ + + +W+EL +QL++ RQQ + E N F +L +WL + E VS G
Sbjct: 2509 WKQMLTEIDSKWQEL-NQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGP 2567
Query: 7738 ILIE-EMIEKLKKDYQ---EEIAIAQENKIQLQQMGERLAKASHESKASE--IEYKLGKV 7791
+ I+ M+ ++ Q +E A + QL G+ + E + ++ +L V
Sbjct: 2568 LSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAV 2627
Query: 7792 NDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEI 7851
+W L ++ R + + +V Q + SL L+ ++++L+ + S + + +
Sbjct: 2628 TQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV-STHPDAM 2686
Query: 7852 QRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD-----------SIQQ 7900
++L Q+++++I++ + LCE L AE ++Q
Sbjct: 2687 NQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQ 2746
Query: 7901 ATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
N + ++ CA S + ++ R +Q +LD K E+ + P S+ +
Sbjct: 2747 KAENHVQHLQSACASSHQ----FQQMSRDFQAWLDT--------KKEEQNKSHPISAKL- 2793
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDN 8020
V + +K + F + + E + L + + +L+ ++ WD
Sbjct: 2794 -DVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDT 2852
Query: 8021 LQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEH-FSECDVQAKIKQLK 8079
K+V +LK + + +++ +++ W+ + L I+ + + I +LK
Sbjct: 2853 FNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLK 2912
Query: 8080 AFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKK- 8138
+ Q+E+ + +E + L+ E +D ++ DE + Q+V E+ H K
Sbjct: 2913 SLQKEMDQHFGMVELLNNTANSLLSVCE-IDKEVVT---DENKSLIQKVDMVTEQLHSKK 2968
Query: 8139 --LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRS 8196
L + E +E + + A L HD L Q SN L++ Q +
Sbjct: 2969 FCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDS-----LGSQAYSNKYLTMLQTQQK 3023
Query: 8197 ERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDV 8256
S+ ++ H DL++ L + E D K G SDV
Sbjct: 3024 ---------SLQALK----HQVDLAKRLAQDLV-------VEASDSK--------GTSDV 3055
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIR------- 8309
++ ++ + +HS L Q+ + L+ I +N IR
Sbjct: 3056 LLQ-------------VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 3102
Query: 8310 -------SKTPTGPELDT------SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGF 8356
S P G + +T + K ++K L +S D+ + + EE+ P
Sbjct: 3103 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 3162
Query: 8357 V----NLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTE 8412
V +L + Q ++DR A ++E +++ +++ ++F S L L E
Sbjct: 3163 VGIKRDLEALSKQCNKLLDR-------AQAREEQVEGTIKRLEEFYSKLKEFSILLQKAE 3215
Query: 8413 EELEQLQRLELSTDIQTIELQIKKLKELQKA-VDHRKAIILSINLCSPEFTQ--ADSKES 8469
E E + + T+ TI Q+ K QK ++ + +N Q A S +
Sbjct: 3216 EHEESQGPVGMETE--TINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTST 3273
Query: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
+ L+ L +N RW + + + LQ+AL+ C F + LL + + +
Sbjct: 3274 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3333
Query: 8530 PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHV 8589
P + Q ++L+Q + +S + V + ++ AE D ++ +++ +
Sbjct: 3334 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGE--KIATTAEPADKVKILKQLSL 3391
Query: 8590 IGNRLKLLLKEVSRHIKELEKLLDVS----SSQQDLSSWSSADE 8629
+ +R + LL + ++LE + V+ + + L+ W + E
Sbjct: 3392 LDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIE 3435
Score = 159 bits (401), Expect = 2e-37
Identities = 417/2207 (18%), Positives = 833/2207 (37%), Gaps = 317/2207 (14%)
Query: 6668 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 1009 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 1066
Query: 6728 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6771
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 1067 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 1126
Query: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6831
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 1127 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 1171
Query: 6832 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6889
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 1172 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 1222
Query: 6890 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 6943
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 1223 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 1282
Query: 6944 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 1283 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1342
Query: 7002 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7059
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1343 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1402
Query: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7108
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1403 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1462
Query: 7109 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7146
EK + S QK S KE +T L +K +
Sbjct: 1463 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1522
Query: 7147 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7190
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1523 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1582
Query: 7191 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1583 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1636
Query: 7244 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7293
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1637 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1696
Query: 7294 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7318
W+ ++ + H + T
Sbjct: 1697 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1756
Query: 7319 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7364
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1816
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7422
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1876
Query: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7470
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1877 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1936
Query: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7530
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1937 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1995
Query: 7531 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7583
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 1996 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 2052
Query: 7584 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7641
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 2053 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 2112
Query: 7642 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7698
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 2113 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 2172
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 2173 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 2227
Query: 7759 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7817
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 2228 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 2286
Query: 7818 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7867
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 2287 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344
Query: 7868 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7905
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2345 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2404
Query: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 7964
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2464
Query: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8022
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--VQAKIKQLKA 8080
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2584
Query: 8081 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2585 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2644
Query: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2645 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2700
Query: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSDV 8256
V E DLS ++ +A S EG + KD
Sbjct: 2701 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKD------------ 2743
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQIQQTENIIRSKTP 8313
+ + E +V+ ++A A Q +Q+ + D++ + Q + I +K
Sbjct: 2744 -VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD 2794
Query: 8314 TGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR 8372
L +K + K L S + ++ E+ L + + S + L +T
Sbjct: 2795 VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----N 2849
Query: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
W+ Q +E ++K++L+K ++ + ++W W+ + LE+ ++ D E
Sbjct: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGEN 2906
Query: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 8492
I KLK LQK +D ++ +N + + + D + + D V L
Sbjct: 2907 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2966
Query: 8493 WRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
+ L++ + + F E+S L E +D + SN +LQ K L
Sbjct: 2967 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 3026
Query: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8608
+KH++ L QD+ + +++GT + +V I L ++V L
Sbjct: 3027 ALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFL 3080
Query: 8609 E-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 8649
E KL + Q + S DELD+ V GR QK
Sbjct: 3081 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 3123
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 373 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 431
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4600 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4648
Query: 432 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 485
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4649 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4692
Query: 486 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 531
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
Query: 532 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 591
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4753 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4807
Query: 592 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 645
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867
Query: 646 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 698
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927
Query: 699 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 753
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987
Query: 754 QD----LEDIEQRVPVMDAQYKIITKT 776
+ +E++ ++ P +D +TKT
Sbjct: 4988 AEHQTFMEEMTRKQPDVDK----VTKT 5010
Score = 33.5 bits (75), Expect = 9.5
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 382 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 433
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4693 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752
Query: 434 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 490
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4753 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4811
Query: 491 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 542
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4812 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4871
Query: 543 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 598
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4872 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4915
Query: 599 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 658
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4916 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4958
Query: 659 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 718
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4959 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 5009
Query: 719 EY 720
Y
Sbjct: 5010 TY 5011
>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
Length = 5171
Score = 336 bits (861), Expect = 7e-91
Identities = 707/4022 (17%), Positives = 1549/4022 (38%), Gaps = 508/4022 (12%)
Query: 1235 LSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQK--TKRI 1292
L G ++Y + L++ I + Q + ++ + A QL +QQK I
Sbjct: 959 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQL---NQQKMLVSEI 1015
Query: 1293 SAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERS---RERQERRIQVTLRKW 1349
K+ + + A+Q + D + + + +D ++S R R + + ++++
Sbjct: 1016 EMKQSKMDECQKYAEQYSATVKDYELQTMT-YRAMVDSQQKSPVKRRRMQSSADLIIQEF 1074
Query: 1350 ERFETNKETVV----RYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAEN 1405
T +V +Y+ G S +R +SL E ++ E +K +
Sbjct: 1075 MDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE--KSLEEEKKEHVEKAKELQKWVSNISK 1132
Query: 1406 LVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKW-----DHFGS 1460
+K+A + P +KQ K E++ ++ L E ++T+++ K D +
Sbjct: 1133 TLKDAEKAGKPPFSKQ------KISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN 1186
Query: 1461 NFETLSVWITEK-----EKELNALETSSSAMDMQISQ--IKVTIQEIESKLSSIVGLEEE 1513
E + E + L L+ S ++ D+++ + + QE + KL I L +
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246
Query: 1514 AQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQ 1573
++ + + E+ I ++++Y + E + ++G+ L++ K EN K
Sbjct: 1247 TEN--RLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQA-LAEVVKNTENFLKENG 1303
Query: 1574 SVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCV 1633
EDK + K+ + K Q ++ Q+ + L +T
Sbjct: 1304 EKLSQEDKALIEQKLNEAKI---KCEQLNLKAEQSKKELDKVVTT--------------- 1345
Query: 1634 QEAAALQQQYEDI--LRRAKERQTALENLLAHWQRLEKE-----------LSSFLTWLER 1680
A++++ E + +++ +E +T +ENLL ++K+ + T +
Sbjct: 1346 ----AIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE 1401
Query: 1681 GEAKASSPEMD--------------ISADRVKVEGELQLIQALQNEVVSQ------ASFY 1720
G+ K++ E D + + + + Q ++A +++SQ A+
Sbjct: 1402 GDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQS 1461
Query: 1721 SKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDEL 1780
+++L K+ + S ++ + ++ ++++L + K++ S+ E ++FD
Sbjct: 1462 AQVLLEKQGQY--LSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1519
Query: 1781 LLSFSVWIKLFLSELQT--TSEISIMDHQVALTRHKDHAAEVESKKGELQ--SLQGHLA- 1835
F W++ EL+ I L R K + +V S KG+L+ ++ G+
Sbjct: 1520 YTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL 1579
Query: 1836 ------------KLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQS 1883
K+ + ++ A D F+ V+ L L + Q
Sbjct: 1580 EAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNN---LKDLVDKYQH 1636
Query: 1884 HASLS-GILRQLRQTVEATNSMNKNESDLIE-KDLNDALQNAKALE----SAAVSLDGIL 1937
+ S G+L L Q EAT S + +E ++ K+L L+ KAL+ S V+++ +
Sbjct: 1637 YEDASCGLLAGL-QACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLK 1695
Query: 1938 SKAQYHLKIGSS--EQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKE 1995
A+ L S + + T D + G E + + + + + QD +
Sbjct: 1696 KTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLD 1755
Query: 1996 ELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQK 2055
E+L + ++E ++ ALQ + LE ++ + + + +K K+ +
Sbjct: 1756 EMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMET 1815
Query: 2056 -DVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
D + A + ++ L + + E + L + ++NL + LE +
Sbjct: 1816 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 1875
Query: 2115 VIVTRTTI--KDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL---SELKKIHSS 2169
+ T + KD +L Y Q+ F KHL S LK+I S
Sbjct: 1876 AL-TEVDVPGKDVTELS-------------QYMQESTSEFLEHKKHLEVLHSLLKEISSH 1921
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS------NNC 2223
+ +D ++K ++S+K +E D ++ + V S +++++ + +
Sbjct: 1922 G---LPSDKALVLEKTNNLSKKFKEMEDTIKEKK---EAVTSCQEQLDAFQVLVKSLKSW 1975
Query: 2224 VPQMAENISNLDNHLRAEELLKEFESEVKNK---ALRLEELHSKVND----LKELTKNLE 2276
+ + + + + AE+L K E K + +L+ E+ KVN+ L L +
Sbjct: 1976 IKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQ-KVNNSGISLCNLISAVT 2034
Query: 2277 TPPDLQFIEADLMQKLEHAKEITEVAKG-TLKDFTAQSTQVEKFINDITTWFTKVEESLM 2335
TP AK I V G + + +T E+F + T +++ +
Sbjct: 2035 TP----------------AKAIAAVKSGGAVLNGEGTATNTEEFWAN--KGLTSIKKDMT 2076
Query: 2336 NCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKK 2395
+ + L +KD EL ++ S + QE +++ + + T
Sbjct: 2077 DISHGYEDLGLL-LKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD 2135
Query: 2396 HEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHD 2455
EAV KTQ +S E +++ + QE L+ KL +
Sbjct: 2136 TEAV-----KTQVEQNKSFEAELKQNVNKVQE---------------------LKDKLTE 2169
Query: 2456 LQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQ 2515
L + + T A KQ+ +T+ + ++Q + + +Q
Sbjct: 2170 L----------------LEENPDTPEAPRWKQM-------LTEIDSKWQELNQLTIDRQQ 2206
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
L++ ++ L F+ +L W+ E E + LG + +V++ L E
Sbjct: 2207 KLEESSNNLTQFQTVEAQLKQWLVEKELMVSV--LGPLSIDPNMLNTQRQQVQILLQEFA 2264
Query: 2576 AARESLDKLSQRGQ-LLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ---VALQ 2631
+ ++L+ GQ +LS G G + QL Q +T + C A+
Sbjct: 2265 TRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIV 2324
Query: 2632 EHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDIL--LMKGEGEVKLN 2689
+ + L+S+ + + ++L+ + + D + ++L Q + + + + ++K+
Sbjct: 2325 KSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVA 2384
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
A+ + AL + + + QLE + + + D+ + + L+S + + + +
Sbjct: 2385 QALCEDLSAL-VKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMS 2443
Query: 2750 NQLEQWMESV--DQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL-------HRL 2800
+ W+++ +Q HP+ + LD L+S++ + +D ++ L +
Sbjct: 2444 RDFQAWLDTKKEEQNKSHPISAK---------LDVLESLIKDHKDFSKTLTAQSHMYEKT 2494
Query: 2801 IAKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2857
IA+ L KT+ S K Q +L KT ++ KE+ K++E ++ L Y + V
Sbjct: 2495 IAEGENLLLKTQG-SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVE 2553
Query: 2858 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2917
W+ Q L +IK +D E G + +++++SL E+ Q+
Sbjct: 2554 TLWPWIDKC-----------------QNNLEEIKFCLDPAE-GENSIAKLKSLQKEMDQH 2595
Query: 2918 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2977
EL++ +L + + ++ V L V + + + Q +
Sbjct: 2596 FGM--VELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK 2653
Query: 2978 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3037
+F + K +QL + + + + + L LQ + + LK Q++ R +
Sbjct: 2654 EFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLA 2713
Query: 3038 RDLSTYSGKVSG----------LIKEYNCLCLQASKGCQNKEQILQ---------QRFRK 3078
+DL + G + +E++ L Q + C E LQ +
Sbjct: 2714 QDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFS 2773
Query: 3079 AFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELL 3138
F +F L + + + + L+K++ ++ ++N MML+ E
Sbjct: 2774 QFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETS 2833
Query: 3139 STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSK 3198
L+ GI+ + A + +E +E ++++F + L K
Sbjct: 2834 PDLV------GIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQK 2887
Query: 3199 TEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQ----AA 3253
E+ HE S + + QQ + + EP L+ K Q + W GQ +A
Sbjct: 2888 AEE--HEESQGPVGMETETINQQLNMFKVFQKEEIEP----LQGKQQDVNWLGQGLIQSA 2941
Query: 3254 SKS-----FRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIH 3308
+KS H + +++++ L+ ++ ++L + +F ++ L WM D
Sbjct: 2942 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3001
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQ 3368
++ + P+++ V+ ++ + + L + +++ +++I GE + P I +
Sbjct: 3002 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3061
Query: 3369 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3428
QL + W +LL+ QLEG + + + + W+ ++E L E +
Sbjct: 3062 QLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQ 3121
Query: 3429 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMT------EHYVTQLELQDLQERYRA 3482
+ + K L +++++++ L G + + + Q +L Q Y
Sbjct: 3122 ASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIE 3181
Query: 3483 IQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAH---THETTL 3539
IQE++ ++ + + + D WL + +KL + SV + ++ L
Sbjct: 3182 IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSEL 3241
Query: 3540 RDLQE--LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETR 3597
R LQE L QALLN L + + +D+ LE+++ ++ ++
Sbjct: 3242 RVLQEDILLRKQNVDQALLNG-LELLKQTTGDEVLIIQDK-LEAIKARYKDITKLSTDVA 3299
Query: 3598 TQFNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYR-DEVEEVGARAQEILDESHV 3656
+ R + +++ WL E + E + +E + R +E+ E+
Sbjct: 3300 KTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKN 3359
Query: 3657 NSRMGCQATQLTS-----------------------RYQALLLQVLEQIKFLEEEIQSLE 3693
N + +++S RY+ + + ++++ ++ I +
Sbjct: 3360 NKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQ 3419
Query: 3694 ESESSLSSYSDWYGSTHKNFKN---VATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3750
+ + + + W T K + + + D+ + +K T+E+L + ++
Sbjct: 3420 QFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEIL-----RHKDIID 3474
Query: 3751 SAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKC 3810
+ G + + E E + ++K++ ++ + + ++ LE+ L +F +
Sbjct: 3475 DLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETY 3534
Query: 3811 KALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE 3870
+ L W+ E Q I+ P +E + Q +++ L++ + H+P + + + G LLE
Sbjct: 3535 EELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3594
Query: 3871 LV-------------------------------------QDVTLKDKIDQLQSDYQDLC- 3892
L Q DKIDQ+ + +
Sbjct: 3595 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 3654
Query: 3893 -------------------SIGKAMMEEIAGFEDRLNNLQMKGDTLIGQC--------AD 3925
S K + ++ + L+ +G+ +I + A
Sbjct: 3655 RLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAK 3714
Query: 3926 HLQAKLKQ------NVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQA 3979
+Q KL Q N+H ++ + + A++ + H+S T++ Q
Sbjct: 3715 AVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCD-------HMSLIVTIKDTQD 3767
Query: 3980 WLSAVQ-PDLEPSP-QPPLSRAEAIKQVKHFRALQEQARTYLDL---LCSMC-DLSNASV 4033
++ ++ P ++PS + AE I++ LQE+ ++L L + C + V
Sbjct: 3768 FIRDLEDPGIDPSVVKQQQEAAETIRE--EIDGLQEELDIVINLGSELIAACGEPDKPIV 3825
Query: 4034 KTTAKDIQQTEQTIEQ----KLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRH 4089
K + ++ ++ + ++ + + Q + + ++ ++ A +L +M
Sbjct: 3826 KKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIG 3885
Query: 4090 SELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKK--EESPEHKEINHLNDQ- 4146
++LE + + ++K F + +Q + + + L KK EES +H + L +
Sbjct: 3886 TDLET--VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELK 3943
Query: 4147 --WLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHL 4204
W L + N + E L + ++ + +L + A+ +
Sbjct: 3944 LIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI 4003
Query: 4205 EALKKLALA--LQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK 4262
E K L + + +E + +IE ++ ++ + L QRW + + +
Sbjct: 4004 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTE 4063
Query: 4263 RKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE 4322
++ Q L + ++L +W + + ++ + P+ A+ L H+ +C+
Sbjct: 4064 QRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAA 4123
Query: 4323 LEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALS 4382
EAK+ KSL++ +++A + I + +++ + + + +R+ L +AL+
Sbjct: 4124 FEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALN 4183
Query: 4383 EKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL 4442
+F ++ + + Q E+ + L+ D V Q+ K + +++ ++ L
Sbjct: 4184 LAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIEL 4243
Query: 4443 WAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDK 4502
G L +Q+ + L +QS ++ V+Q+ R + L+ K F E + K
Sbjct: 4244 DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4303
Query: 4503 ACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSL 4562
WL++++ E+ + N+ ++ TQLA+++ + ++ T RTG+++
Sbjct: 4304 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKT 4363
Query: 4563 NEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEA 4621
+ D + L + L+ L +++ I + ++ K++EA+L ++ ++ L +E
Sbjct: 4364 SLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4423
Query: 4622 QFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKK----EGFRSTGQPWQ 4677
Q V D ++ ++L D +A E+ +V L + EG R W
Sbjct: 4424 QLAEDQPVHGD--IDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS-WV 4480
Query: 4678 PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEET 4737
+M L T + + + + + LE +E + L L + EQ+
Sbjct: 4481 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWL--AEAEQTLRFHGV 4538
Query: 4738 LPAEEK-----LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQG 4792
LP +E + + L++ L + T + + P + +H I +
Sbjct: 4539 LPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA 4598
Query: 4793 ELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEE 4852
+ + + + S + I Q + L WL+ + L+ D + + I +E
Sbjct: 4599 RFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLT-----DKDKEVIPQE 4653
Query: 4853 IRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRT 4912
I +++ E Q+ + M + +K TK + +AD + + LD R
Sbjct: 4654 IEEVKALIAEHQTFMEEMTR-KQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRF 4712
Query: 4913 RQATLTEIYSQCQ-------------RYYQVFQAA-------NDWLEDAQELLQLAGNGL 4952
++L SQ Q ++ QV+ A ND L+ +EL + A
Sbjct: 4713 PASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDF 4772
Query: 4953 DV 4954
D+
Sbjct: 4773 DI 4774
Score = 322 bits (825), Expect = 1e-86
Identities = 858/4699 (18%), Positives = 1838/4699 (39%), Gaps = 637/4699 (13%)
Query: 3186 EVSAEPIQDWLSKTEKMVHESSNRLY--DLPAKRREQQKLQSVLEEIHCYEPQLNRLKEK 3243
E++ + +QD L+ ++M + + DLP+ + ++V I +E L K
Sbjct: 276 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 335
Query: 3244 AQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWM 3303
Q+ ++ ++ +L SQY L N ++ + LD + HN S EL W+
Sbjct: 336 EIQMTA--PLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTL---HNFVSRATNELI-WL 389
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
+ +Y + ++ + E + + Q++E +K + E +L P +
Sbjct: 390 NEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE-NIKSVQEIAEQLLLENHPARL 448
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEA-----N 3418
TI+ +++ W+ +L C+ +E + + T+Y F + D+ EA N
Sbjct: 449 -TIEAYRAAMQTQWSWILQL---CQC-VEQHIKENTAY------FEFFNDAKEATDYLRN 497
Query: 3419 LNESERQHAELRDKTTMLGKAKLL-------NEEVLSYSSLLET--------IEVKGAGM 3463
L ++ ++ D+++ + K + L EE+L Y S + I++K
Sbjct: 498 LKDAIQRKYSC-DRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNS 556
Query: 3464 TEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQE----- 3518
T + ++ + + YR I+ + K ++ V + ++ K G E
Sbjct: 557 DCPLKTSIPIKAICD-YRQIEI----TIYKDDECVLANNSHRAKWKVISP-TGNEAMVPS 610
Query: 3519 ---------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPS 3569
+E +D + +E T + L+N + R + S
Sbjct: 611 VCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVAS 670
Query: 3570 ---GIPQAEDRALESLRQDWQAYQHRLSETR-------TQFNNVVNKLRLMEQKFQQVDE 3619
+P + L +L+ ++ + E++ TQ VN + Q E
Sbjct: 671 IKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCK------QYYQE 724
Query: 3620 WLKTAEEKKWHEEV-TAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQV 3678
LK+AE ++ E V Y EV + R + D R + L + ++
Sbjct: 725 LLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHES----VFRI 780
Query: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGK-------- 3730
EQ K L++E++ L++ ++++ + + S +V T +++ V+
Sbjct: 781 TEQEK-LKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSS 839
Query: 3731 ----KLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELT 3786
KLKT+ ++LK+ + +L+K K L E EA K ++ L
Sbjct: 840 TYIDKLKTVNLVLKNTQAAEALVKLYETK-------LCEEEAVIADKN------NIENLI 886
Query: 3787 STVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSK-YK 3845
ST++ QW +E E V + EL + KA + +K
Sbjct: 887 STLK------------------------QWRSEVDEKRQVFHALEDELQKAKAISDEMFK 922
Query: 3846 SLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGF 3905
+ ++ L + +EK + L+E Q+V + Q+ + +DL IGK++ +
Sbjct: 923 TYKERDLDFDWH----KEKADQLVERWQNVHV-----QIDNRLRDLEGIGKSLKY----Y 969
Query: 3906 EDRLNNLQMKGDTLIGQCADHLQAKLKQNV--HAHLQGTKDSYSAICSTAQRMYQSLEHE 3963
D + L D I Q + Q K+++N ++ T+ + + + M QS E
Sbjct: 970 RDTYHPL----DDWIQQ-VETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDE 1024
Query: 3964 LQKHVSRQD-TLQQCQAWLSAVQPDLEPSPQPPLSR----AEAIKQVKHFRALQEQARTY 4018
QK+ + T++ + + ++ + P+ R + A ++ F L+ +
Sbjct: 1025 CQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTAL 1084
Query: 4019 LDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA 4078
+ L+ + S+K ++ + E+ ++ + +A+ L Q W S + L+DA
Sbjct: 1085 VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-QKWV------SNISKTLKDA 1137
Query: 4079 DQQLQN--MKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE 4136
++ + K++ S E++ + +S+ ++ +K +K+T +E +
Sbjct: 1138 EKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHG---------DKMTDEERNEL 1188
Query: 4137 HKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVV----EVFLEKFTTEWDNL 4192
K++ L + + L +S L++ ++ Q + D +V + + EK D L
Sbjct: 1189 EKQVKTLQESYNLLFSES----LKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLL 1244
Query: 4193 ARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQ 4252
+++ H EA ++ +KY + +++ QK ++ E+VK + L++
Sbjct: 1245 TQTENRLIG-HQEAFMIGDGTVELKKY--QSKQEELQKDMQGSAQALAEVVKNTENFLKE 1301
Query: 4253 RWFQLED----LIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDM 4308
+L LI++K+ + E+LN+ + ++ E + A+K+
Sbjct: 1302 NGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKK------ELDKVVTTAIKEET---- 1351
Query: 4309 AQNLLMDHLAICSELEAKQMLLKSLI---KDADRVMADLGLNERQVIQKALSDAQSHVNC 4365
+ +A +LE + +++L+ + D+ G +QVI++ + Q
Sbjct: 1352 ------EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG- 1404
Query: 4366 LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTC 4425
+G+ + L + Q + Q +K+ ++ K
Sbjct: 1405 -KSAIGEEDEVNGNLLETDVDGQVGTTQ--ENLNQQYQKVK------------AQHEKII 1449
Query: 4426 KSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVL------QKC 4479
QA + Q+ L QG+ L E EK ++ ++EL+ Y++ L K
Sbjct: 1450 SQHQAVIIATQSAQVLLEKQGQYLSPE----EKEKLQKNMKELKVHYETALAESEKKMKL 1505
Query: 4480 SHRLQE-LEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE----LHTQLAKY 4534
+H LQE LEK F D+ + HWL+Q++ E+ + ++ L T+L +
Sbjct: 1506 THSLQEELEK-------FDADYTEFEHWLQQSE----QELENLEAGADDINGLMTKLKRQ 1554
Query: 4535 QNILEQSPEYENLLLTLQRTGQTILPSLN--------EVD----HSYLSEKLNALPRQFN 4582
++ E ++ L + +G +L + +VD H + KL+ +F
Sbjct: 1555 KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFR 1614
Query: 4583 VIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQ 4642
+ + +++ + +Y + + L+ L+A SK ++ + +LQ
Sbjct: 1615 SLYSKCNVLGNNLKDLV---DKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1671
Query: 4643 ---DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK------MLHLVTLYHRLKR 4693
+ +A+ +++ AV++L + E P K + +V Y L +
Sbjct: 1672 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 1731
Query: 4694 QTEQRVSLLEDTT----SAYQEHEKMCQQLERQLKSVKEE-QSKVNEETLP--AEEKLKM 4746
+R L+ T S ++M + S+KE+ Q +N L + + +
Sbjct: 1732 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIML 1791
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+AG + ++V +E DP + +++ + ET+
Sbjct: 1792 EQDIAGRQSSINAMNEKVKKFMETT----DPSTASSLQAKMKDLSARFSEASHKHKETLA 1847
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSS 4866
+ E + ++ +S L K + V D+ +D+ E + +Q E
Sbjct: 1848 KMEE-LKTKVELFENLSEKLQTFLETKTQALTEV--DVPGKDVTELSQYMQESTSEFLEH 1904
Query: 4867 LRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQR 4926
+ + L KE + A + LS+ ++++ ++ ++ +T Q
Sbjct: 1905 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 1964
Query: 4927 YYQVFQAANDWLEDAQE---LLQLAGNGLDVESAEENLKSHMEFFSTE----DQFHSNLE 4979
+ + ++ W+++ + ++Q + D+ + E+ K E +S + + +++
Sbjct: 1965 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2024
Query: 4980 ELHSLVATLDPLIKP-----------------TGKEDLEQKVASLELRSQRMSRDSGAQ- 5021
L +L++ + K T E+ ++ G +
Sbjct: 2025 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYED 2084
Query: 5022 -----VDLLQRCTAQWHDYQKAREE---VIELMNDTEKKLSEFSLLKTSSSHEA-EEKLS 5072
D + + QKA+EE +++ + K +++ + EA + ++
Sbjct: 2085 LGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVE 2144
Query: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTT-VWQRWTRLRAVAQDQ 5131
++K+ + + K+ L++K ++L + D +A + M T + +W L + D+
Sbjct: 2145 QNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDR 2204
Query: 5132 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFV---- 5187
++ LE++ + T F ++ +L EK +L L +
Sbjct: 2205 QQKLEESSNNLTQFQT-----------VEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2253
Query: 5188 --LELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLM----QEITAMQDRCLNMQEKVK 5241
+++ Q+ A + + L+ G PGE+P L +++ A+ + ++ ++
Sbjct: 2254 QQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLS 2313
Query: 5242 TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTI------EIDAQLEELQILLTE 5295
+ Q + ++ + S+ + + L + ++ QLE Q + E
Sbjct: 2314 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2373
Query: 5296 ATNHRQNI-------EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLK-IRDQIQDKIK 5347
++ I E ++ KE+YL +ELS QL + K + + ++ ++
Sbjct: 2374 IQQEKKQIKVAQALCEDLSALVKEEYL------KAELSRQLEGILKSFKDVEQKAENHVQ 2427
Query: 5348 EVEQSKATS---QELSRQIQK---LAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5401
++ + A+S Q++SR Q K+ + AK D + D K + L
Sbjct: 2428 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTA- 2486
Query: 5402 NSKLMELDAAVQK--FLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLE 5459
S + E A + L+ G L ++ + +Q + R +KL ++
Sbjct: 2487 QSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKAL 2546
Query: 5460 EYNEMLELILKWIEKAK----------VLAHGTIAWNSASQLREQYILHQTLLEESKEID 5509
+Y E +E + WI+K + A G + L+++ H ++E
Sbjct: 2547 KYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA 2606
Query: 5510 SELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAE 5569
+ L ++ E + T++ + ++ TE+L K L+N+ K+ ++ E
Sbjct: 2607 NSLLSVCE----IDKEVVTDENKSLIQKVDMVTEQLHSK-KFCLENMTQKFKEFQEVSKE 2661
Query: 5570 LKK-LQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ-AVQLCQSALRI 5627
K+ LQ A EQ + + + L+ Q +++LK +V A +L Q +
Sbjct: 2662 SKRQLQCAKEQLD--IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVE 2719
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
D + + + +E S L ++C+ ++ + ++ ++ +
Sbjct: 2720 ASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFD 2779
Query: 5688 REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTV 5747
E++ + + LQ Q + +K++ + N CKM+ + + L+ +
Sbjct: 2780 DELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGI 2839
Query: 5748 -TEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE-----ESGEEGTNSE 5801
++E L++ +LL A V T R S + E + EE S+
Sbjct: 2840 KRDLEALSKQC----NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQ 2895
Query: 5802 ISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPS 5861
PV ++NQ + ++ E ++ K Q + + +
Sbjct: 2896 ----------GPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKST 2945
Query: 5862 ATA----KLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQS-ISTKMEAIELKLS 5916
+T L D+ W+TL ++++ L EAL ++QD+L+S +S ++ EL +
Sbjct: 2946 STQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVAN 3005
Query: 5917 ESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCE-----ADPAEQLA 5971
+ P P ++ +A + E +LQ +++ +S++ E++ E A+PA+++
Sbjct: 3006 QKP-----PSAEFKVVKAQIQEQKLLQRLLDDRKSTV--EVIKREGEKIATTAEPADKVK 3058
Query: 5972 LQSTLTVLAERMSTIRMKASGKRQLLE-------------EKLNDQLE--EQR------- 6009
+ L++L R + KA + + LE E LN+ L E+R
Sbjct: 3059 ILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPI 3118
Query: 6010 --QEQALQRYRCEADELDSWLLSTKATLDTALS--------PPKEPMDMEAQLMD-CQNM 6058
Q L+ + L+ +++ L A+S +E DM +D Q
Sbjct: 3119 GTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVW 3178
Query: 6059 LVEIEQKVVALSELSVHNENLLLEGKAHTKDEAE------QLAGKLRRL----------- 6101
+EI++K + SEL + L K +DE E ++ KL +L
Sbjct: 3179 YIEIQEKSHSRSELL---QQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLW 3235
Query: 6102 --KGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6159
+ L LQ + ++ N+ E T + +Q+ L + + + S
Sbjct: 3236 KQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3295
Query: 6160 LQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG-MEGEKS 6218
K LEQ L L R + S EE+ E ++LS E ++GE++
Sbjct: 3296 TDVAKTLEQAL----QLARRLHSTHEELCTWLDKVEV--------ELLSYETQVLKGEEA 3343
Query: 6219 SAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKS 6278
S Q +M+ + L +E + LL + L + +L P R G+ + +D
Sbjct: 3344 S---QAQMRPKELKKEAKNNKALLDS-LNEVSSALLELVPWRAREGLE----KMVAEDNE 3395
Query: 6279 AVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLP 6338
+ D + Q EE+ + +I Q+ A +W+ + E++L +
Sbjct: 3396 RYRLVSDTITQKVEEIDA--------AILRSQQFDQAADAELSWITETEKKLMSLGDIRL 3447
Query: 6339 EETETC-------LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
E+ +T F EIL K++ +++ K+ + A E + + ++ L +L
Sbjct: 3448 EQDQTSAQLQVQKTFTMEILRH--KDIIDDLVKSGHKIMTACSE--EEKQSMKKKLDKVL 3503
Query: 6392 GRLSLLDSVVNQRCHQMKERLQQILN-FQNDLKVLFTSLADNKYIILQKLANVFE-QPVA 6449
+ + ++R Q+ ER Q ++N F + L+ L + + II Q A E + +
Sbjct: 3504 KNYDTICQINSERYLQL-ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLR 3562
Query: 6450 EQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQP----SMQELSKLQD-MYDELMMIIG 6504
+Q E +Q + + E I ++ + G +L P S+QE D +Y ++ +
Sbjct: 3563 QQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVK 3622
Query: 6505 SRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQ 6564
R L++ ++ +Q+ + + + LE E++ I + E+I++ + ++K
Sbjct: 3623 KRAVALDEAISQSTQFHDKIDQILESLERIVERLR-QPPSISAEVEKIKEQISENKNVSV 3681
Query: 6565 GLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVE--LEYILETWSH 6622
+E L ETL Q E++A++ K + V+ L+ ++ W +
Sbjct: 3682 DMEKLQPLYETL------------KQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWEN 3729
Query: 6623 L----DEDQQELSRQLEVVE-------SSIPSV----GLVEENEDRLIDRITLYQH---- 6663
+ +E + +L +E+ E S I ++ + + ED ID + Q
Sbjct: 3730 IHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAA 3789
Query: 6664 --LKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHR 6718
++ ++ Q +L V++ G L+ + D ++ +++L W S + +
Sbjct: 3790 ETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDK 3849
Query: 6719 LETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEV 6778
LE ++ +YQ + W+ A +L + + +LE V+ + +F E
Sbjct: 3850 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS----PIGTDLETVKQQIEELKQFKSEA 3905
Query: 6779 DAQSSLKSSVLSTGNQLLRLKKV----DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQL 6834
Q ++ L+ +LL LKKV D T++ L + W L I Q KL
Sbjct: 3906 -YQQQIEMERLNHQAELL-LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGA 3963
Query: 6835 QMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIG--YKAIHEYLQKYKGFKIDINCK 6892
+ +HA+ E+++W++ E ++ + + +G KAI L K+ + D+
Sbjct: 3964 LLALGQFQHALDELLAWLTHTEGLLSE-----QKPVGGDPKAIEIELAKHHVLQNDVLAH 4018
Query: 6893 QLTVDFVNQSVLQISSQDVESKRSDK-TDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q TV+ VN++ + +ES ++ ++ +L +N+ WQ + ++ Q L+G L
Sbjct: 4019 QSTVEAVNKA----GNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4074
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQHRIGD-QASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ ++ L+ W E+ L +G + + L ++ +AKE+ + +
Sbjct: 4075 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4134
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
Q G ++ + + + + L + W +++ + + K L+ L+ +
Sbjct: 4135 MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQD 4194
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++L +A +L+ + L+ V Q+D + +++ + + L
Sbjct: 4195 FINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFS 4254
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQS-------SKALLQLWQRYKDYSKQCAST 7183
+ N L V RW +++ + E+ +S +K + W + ++ ++ +
Sbjct: 4255 QKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKS 4314
Query: 7184 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
+ + + N+ D++ T + + K LG + G LK++
Sbjct: 4315 LDSELEIAND-----------PDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEK- 4362
Query: 7244 DASAASAIQSDQLSLSQHLCALE---QALC----KQQTSLQAGVLDYETFAKSLEALEAW 7296
+++ D L L L L +C ++Q L+ +L F +L+AL W
Sbjct: 4363 -----TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDW 4417
Query: 7297 IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7356
+ E L P H D+ + ++ K + + L L ++
Sbjct: 4418 LYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDD 4476
Query: 7357 K-----RMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7411
+MQ L+ W + + + + ++L++ L Q + F +E+L + EQ L
Sbjct: 4477 SSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFH 4536
Query: 7412 --ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLL 7469
+ + L H+ F ++ ++ L+ G +L D +T++
Sbjct: 4537 GVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITII 4596
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV-EVSYLPMSGLGSVPIPLQQ 7528
+++ V+ A+Q + + S + +E+ E L WL + L +P +++
Sbjct: 4597 RARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEE 4656
Query: 7529 ARTLFDEVQ-FKEKVFLRQ 7546
+ L E Q F E++ +Q
Sbjct: 4657 VKALIAEHQTFMEEMTRKQ 4675
Score = 312 bits (799), Expect = 1e-83
Identities = 770/4311 (17%), Positives = 1668/4311 (38%), Gaps = 501/4311 (11%)
Query: 1482 SSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK------LTQ 1535
S S + ++ V Q + L S E+E + +++ + R++ + + Q
Sbjct: 704 SGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQ 763
Query: 1536 IRRYGEELREHAQCLEGTILGHLSQQ-QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE 1594
IR E H T L ++ ++ +++L I EF + A + + +E
Sbjct: 764 IRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSE 823
Query: 1595 TYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQ 1654
VLQ + S+SS + V+ Q A AL + YE L
Sbjct: 824 LNVVLQN----MNQVYSMSSTYIDKLKTVNLVLKN---TQAAEALVKLYETKLCEE---- 872
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
E ++A +E +S+ W R +V+ + Q+ AL++E+
Sbjct: 873 ---EAVIADKNNIENLISTLKQW------------------RSEVDEKRQVFHALEDEL- 910
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKM--MKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
K + + +F + D+ K +QL ERW+++ I+ R+ L+ +
Sbjct: 911 ------QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGK 964
Query: 1773 EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQ--------VALTRHKDHAAEVESKK 1824
+ + + WI+ +++TT I ++Q L + K +E+E K+
Sbjct: 965 SLKYYRDTYHPLDDWIQ----QVETTQR-KIQENQPENSKTLATQLNQQKMLVSEIEMKQ 1019
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH---LAEFL 1881
++ Q + + + + +L + +A + + V+RR++ S + EF+
Sbjct: 1020 SKMDECQKYAEQYSATVKDYELQTMTYRA----MVDSQQKSPVKRRRMQSSADLIIQEFM 1075
Query: 1882 QSHASLSGILRQLRQTVE-ATNSMNKNESD--LIEKDLNDALQNAKALESAAVSLDGILS 1938
+ ++ + Q ++ A +S+ + E + +E++ + ++ AK L+ ++ L
Sbjct: 1076 DLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLK 1135
Query: 1939 KAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELL 1998
A+ K S+Q+ S ++++ + E++ L T Q L + K
Sbjct: 1136 DAEKAGKPPFSKQKIS----SEEISTKKEQLSEALQTIQ-----LFLAKHG--------- 1177
Query: 1999 KSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWL-KDKAKQIAQKDV 2057
++ TD+ER N+LE ++ + + L + KQ+ +
Sbjct: 1178 ------DKMTDEER----------------NELEKQVKTLQESYNLLFSESLKQLQESQT 1215
Query: 2058 AFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIV 2117
+ +V+ +I E + + G+ DL+ + +N +++ + + ++
Sbjct: 1216 SGDVKVEEKI---------VAERQQEYKEKLQGICDLLTQTEN------RLIGHQEAFMI 1260
Query: 2118 TRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL-KKIHSSDFSLVKT 2176
T+ +LK SK E + M + L ++ L E +K+ D +L++
Sbjct: 1261 GDGTV----ELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQ 1316
Query: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDN 2236
+ K ++ K E++ L D V++T + E V Q+ E+ + ++N
Sbjct: 1317 KLNEAKIKCEQLNLKAEQSKKEL-------DKVVTTAIKEETEKVAAVKQLEESKTKIEN 1369
Query: 2237 HLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAK 2296
L ++ S V + R H +V + F E D +
Sbjct: 1370 -------LLDWLSNVDKDSERAGTKHKQVIEQN----------GTHFQEGDGKSAIGEED 1412
Query: 2297 EITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKEL 2356
E+ T D +TQ ++ + KV+ AQ+E K +
Sbjct: 1413 EVNGNLLETDVDGQVGTTQ-----ENLNQQYQKVK------AQHE------------KII 1449
Query: 2357 QSQQSNISSTQEN---LNSLCRKYHSAELESLGRAMTGLIKKHE---AVSQLCSKTQASL 2410
Q+ I +TQ L + E E L + M L +E A S+ K SL
Sbjct: 1450 SQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSL 1509
Query: 2411 QESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470
QE LEK F EF+ W ++ + D L KL ++ + V + L
Sbjct: 1510 QEELEK-FDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDL 1568
Query: 2471 DAVTQEGQTLYAHLSK-------QIVSS-----IQEQITKANEEFQAFLKQCLKDKQALQ 2518
+T G + ++ +S +Q ++ A + F++ +C L+
Sbjct: 1569 RYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK 1628
Query: 2519 DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEK-KNEVHKVEMFLGELLAA 2577
D + +ED L + E + ++L E P+ + ++ + + G++ +
Sbjct: 1629 DLVDKYQHYEDASCGLLAGLQACEATAS-KHLSEPIAVDPKNLQRQLEETKALQGQISSQ 1687
Query: 2578 RESLDKLSQRGQ-LLSEEGH---GAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEH 2633
+ +++KL + + LL G + ++ +++L + E+ Q+ L
Sbjct: 1688 QVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRS 1747
Query: 2634 EALEEALQSMWFWVKAIQDRLA----CAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLN 2689
++++ L M W+ ++ L ++ +D + K + QDI + +N
Sbjct: 1748 LSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDI----AGRQSSIN 1803
Query: 2690 MAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERK 2749
K ++ + +++ +Q +++ L +++ + +E + ++ +
Sbjct: 1804 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 1863
Query: 2750 NQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRE--- 2806
+L+ ++E+ Q + P + E + S E + H LH L+ +
Sbjct: 1864 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGL 1923
Query: 2807 ------LYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLD------ 2854
+ EKT + S K E+ + + +T +E++ + +VK ++
Sbjct: 1924 PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKV 1983
Query: 2855 -------AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRV 2907
+ L K+ +WS + + + LI + A ++ V
Sbjct: 1984 PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAV 2043
Query: 2908 ESLAPEVKQNTTASGCELMHTE--MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEF 2965
+S + TA+ E + +++ D L++ ++ E
Sbjct: 2044 KSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIA-------EL 2096
Query: 2966 SGQVAQLEQALEQFSALLKTWAQQLTLLEGK------NTDEEIVECWHKGQEILDA-LQK 3018
+ ++++L++A E+ SA+++ W Q++ K TD E V+ + + +A L++
Sbjct: 2097 NTKLSKLQKAQEESSAMMQ-WLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2155
Query: 3019 AEPRTEDLKSQLNELCRFSRDL------STYSGKVSGLIKEYNCLCLQASKGCQNKEQIL 3072
+ ++LK +L EL + D ++ +E N L + + + L
Sbjct: 2156 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2215
Query: 3073 QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMML 3132
Q F+ +QWLV ++ + + + + ++T Q++Q L E + + +
Sbjct: 2216 TQ-FQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLT 2274
Query: 3133 SKGE-LLSTLLTKEKAKGI-QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAE 3190
+ G+ +LS +GI + ++ A + W + L + ++ ++ ++
Sbjct: 2275 AAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLR 2334
Query: 3191 PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEG 3250
+ D LS + + S A ++ + Q + +EI + Q+ + AQ L E
Sbjct: 2335 SLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI----KVAQALCED 2390
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKE-------KVSRLDRIVAEHNQFSLGIKELQDWM 3303
+A + ++LS Q + K+ V L A +QF ++ Q W+
Sbjct: 2391 LSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWL 2450
Query: 3304 TDAIHMLDSYCHPTSDK-SVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEG 3362
D + HP S K VL+S + + + + GE++L T
Sbjct: 2451 -DTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSE 2509
Query: 3363 IPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNE- 3421
+Q QL ++K W + +++L+ +L K Y++ V W+D + NL E
Sbjct: 2510 KAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEI 2569
Query: 3422 --------SERQHAELR----DKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
E A+L+ + G +LLN +SLL E+ +T+
Sbjct: 2570 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTA---NSLLSVCEIDKEVVTD---- 2622
Query: 3470 QLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLE 3529
E + L ++ + E+ E + + +E+Q K + L +E+LD + L
Sbjct: 2623 --ENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLG 2680
Query: 3530 GDAHTHE-TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRAL--ESLRQDW 3586
A++++ T+ Q+ + + Q L L V S D L E++ Q+
Sbjct: 2681 SQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEH 2740
Query: 3587 QAYQHRLSE------TRTQ-FNNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDE 3639
++ E T+ Q + N +R M +F + D+ L + E + E
Sbjct: 2741 STLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKE 2800
Query: 3640 VEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL------- 3692
+ + E L S+ N+ C+ T L+ + ++ L ++ L
Sbjct: 2801 TIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAR 2860
Query: 3693 -EESESSLSSYSDWYGSTHKNFKNVATKIDK---------VDTVMMGKKLKTLEVLLKD- 3741
E+ E ++ ++Y S K F + K ++ ++T + ++L +V K+
Sbjct: 2861 EEQVEGTIKRLEEFY-SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 2919
Query: 3742 MEKGHSLLKSAREKGERAVKYLEEGEAER-LRKEIHDHMEQLKELTSTVRKEHMTLEKGL 3800
+E + G+ ++ + + + L ++ D + K L V + L++ L
Sbjct: 2920 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 2979
Query: 3801 HLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKS 3860
F D ++L W+ + +E++ + P E KAQ+ + K LQ+ + + +V+
Sbjct: 2980 LHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEV 3039
Query: 3861 VREKGEALL---ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
++ +GE + E V + ++ L S ++ L + KA N Q++G
Sbjct: 3040 IKREGEKIATTAEPADKVKILKQLSLLDSRWEAL--LNKA----------ETRNRQLEGI 3087
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQC 3977
+++ Q L + + T + C LE ++ +H + +D +
Sbjct: 3088 SVVAQQFHETLEPLNEWLT-----TIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINH 3142
Query: 3978 QAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTA 4037
L +S +++K + +R D++ S D S
Sbjct: 3143 NKHLHQA-----------VSIGQSLKVLS--------SREDKDMVQSKLDFSQVWYIEIQ 3183
Query: 4038 KDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDA---DQQLQNMKRRHSELEL 4094
+ + ++Q L A+ + E+ + +E+ L D + + ++ SEL
Sbjct: 3184 EKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR- 3242
Query: 4095 NIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQS 4154
V Q ++K QA +N + E + + T E ++ + ++ D+ + S
Sbjct: 3243 ------VLQEDILLRKQNVDQALLNGL-ELLKQTTGDEVLIIQDKLEAIKARYKDITKLS 3295
Query: 4155 NNLCLQREEDLQRTRDYHD-----CMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKK 4209
++ E+ LQ R H C + +V +E + E L +A + + LKK
Sbjct: 3296 TDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKK 3355
Query: 4210 LALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ-VS 4268
A + K ++ L + ++E + +E +++ + +R+ + D I +K++ +
Sbjct: 3356 EA---KNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID 3412
Query: 4269 VTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQM 4328
L Q+ EL W E + + D L E+ +
Sbjct: 3413 AAILRSQQFDQAADAEL-SWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKD 3471
Query: 4329 LLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFL 4388
++ L+K ++M E+Q ++K L + + + + +R L +A S QF
Sbjct: 3472 IIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3531
Query: 4389 MAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRE 4448
+ + + + I L + + +Q + + + + ++ + + G +
Sbjct: 3532 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3591
Query: 4449 LMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLK 4508
L+ E++ E + K ++Y + + R L++ + F + D+ L+
Sbjct: 3592 LL-ELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLE 3650
Query: 4509 QADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHS 4568
+ ++ E ++ Q+++ +N+ + + L TL++ G+ ++ D
Sbjct: 3651 RIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKD 3710
Query: 4569 Y----LSEKLNALPRQFNVIVALAKDKFYKVQEAI-LARKEYASLIELTTQSLSELEAQF 4623
+ +KL+ + + I L +++ K+ + + LA K + + L ++ + + F
Sbjct: 3711 ISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV-TIKDTQ-DF 3768
Query: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVD-ELNQKKEGFRSTGQPWQP---D 4679
+R + P + Q+ I +E+ GL E +D +N E + G+P +P
Sbjct: 3769 IRDLEDP-GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKK 3827
Query: 4680 KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNE---- 4735
+ L + + L + + R+ LE+ A +++ Q + + + + ++
Sbjct: 3828 SIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTD 3887
Query: 4736 -ETLPAE-EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGE 4793
ET+ + E+LK + S A Q I ++R+ E L L + E +H +Q E
Sbjct: 3888 LETVKQQIEELKQFKSEAYQQQ---IEMERLNHQAELL---LKKVTEESDKHTVQDPLME 3941
Query: 4794 LKLLTSAIGETVTECESRMVQSI----DFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDI 4849
LKL+ ++ E + + ++ ++ FQ + L WL + LS + + + I
Sbjct: 3942 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4001
Query: 4850 QEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEA 4909
+ E+ K + Q +V + + A++ + + +++L++ L L++ ++ E
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4061
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKSHME- 4966
R+ L Q + ++ + WL D + L LA L E+A+E L HME
Sbjct: 4062 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL-LASKPLGGLPETAKEQLNVHMEV 4120
Query: 4967 ---FFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVD 5023
F + E+ + S +++ ++A + + +++Q + +L+ + + + +
Sbjct: 4121 CAAFEAKEETYKSLMQKGQQMLARCPK----SAETNIDQDINNLKEKWESVETKLNERKT 4176
Query: 5024 LLQRCTAQWHDYQKAREEVIELMNDTEKKL---SEFSLLKTSSSHEAEEKLSEHKALVSV 5080
L+ ++ + ++ I + E+ L S SL+ + + + EHK +
Sbjct: 4177 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQ----IDEHKVFANE 4232
Query: 5081 VNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140
VNS E+I+ L++ + L+ + + +V RW ++ ++ + L+DA
Sbjct: 4233 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4292
Query: 5141 EWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGML 5200
F+ K E +++ + L ++ T L H F L + S
Sbjct: 4293 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4352
Query: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKT-NGKLVKQELKDREMV-- 5257
+ S+ E+ L + + D +++K T GK V+++ K E +
Sbjct: 4353 NRTGRSL---------KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLF 4403
Query: 5258 ----ETQINSVKCWVQETKEYLGNPTIEIDAQLE-ELQILLTEATNHRQNIEKMAEEQKE 5312
+ ++ W+ Y P + D + ++ +++ NH+ +
Sbjct: 4404 SGQFTDALQALIDWL-----YRVEPQLAEDQPVHGDIDLVMNLIDNHK---------AFQ 4449
Query: 5313 KYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTT 5372
K LG T S+Q AL R+ I+ + K QELS + + + +
Sbjct: 4450 KELGKRT-----SSVQ----ALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSIS 4500
Query: 5373 ILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGK 5432
T+L+A EE L+E A ++ L +G L +
Sbjct: 4501 KQTRLEAALRQ-----------AEEFHSVVHALLEWLAEAEQTLRFHGVLPDD-EDALRT 4548
Query: 5433 LTELHQQTIRQAENRLSKLNQAASHLEE-----YNEMLELILKWIEKAKVLAHGTIAWNS 5487
L + H++ +++ E + ++LN+A + + + + + I WI + +AW
Sbjct: 4549 LIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAK 4608
Query: 5488 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQ 5547
Q R L + ++ LEA+ LQ+ + T+K + + + E EE++
Sbjct: 4609 QHQQRLASALAGLIAKQEL-----LEALLAWLQWAETT-LTDKDKEVIPQ---EIEEVKA 4659
Query: 5548 MI---KIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
+I + ++ + D+ K K+ A Q+ + + GR K
Sbjct: 4660 LIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRK 4710
Score = 298 bits (764), Expect = 1e-79
Identities = 722/4020 (17%), Positives = 1553/4020 (38%), Gaps = 449/4020 (11%)
Query: 4877 EKEKFTKAKELISADLE---------HSLAELSELDGDIQEALRTRQATLTEIYSQCQRY 4927
E+EK K E + DL S A S ++ L + ++YS Y
Sbjct: 782 EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841
Query: 4928 YQVFQAANDWLED---AQELLQLAGNGLDVESAE-------ENLKSHMEFFSTE-----D 4972
+ N L++ A+ L++L L E A ENL S ++ + +E
Sbjct: 842 IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQ 901
Query: 4973 QFHSNLEELHSLVATLDPLIKPTGKEDLE-----QKVASLELRSQRMSRDSGAQVDLLQ- 5026
FH+ +EL A D + K + DL+ +K L R Q + ++ L+
Sbjct: 902 VFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEG 961
Query: 5027 --RCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084
+ + D ++ I+ + T++K+ E + +S +L++ K LVS +
Sbjct: 962 IGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN---QPENSKTLATQLNQQKMLVSEIEMK 1018
Query: 5085 HEKIVALEEKASQLEKTGNDASKATLS-RSMTTVWQRW-TRLRAVAQDQEKILEDAVDEW 5142
K+ ++ A Q T D T++ R+M Q+ + R + + I+++ +D
Sbjct: 1019 QSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR 1078
Query: 5143 TGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQ 5202
T + V T+ I D L E+ S E + H EL++ S +
Sbjct: 1079 TRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEK---KEHVEKAKELQKWVSNIS---- 1131
Query: 5203 QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKV-----KTNGKLVKQELKDRE-M 5256
+TL + P ++ +EI+ +++ + + K K+ +E + E
Sbjct: 1132 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1191
Query: 5257 VETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLG 5316
V+T S E+ + L D ++EE + + + +E KEK G
Sbjct: 1192 VKTLQESYNLLFSESLKQLQESQTSGDVKVEE------------KIVAERQQEYKEKLQG 1239
Query: 5317 LYTILPS--------ELSLQLAEVALDLKIRDQIQDKIKEVEQSKA---------TSQEL 5359
+ +L + + + + ++LK Q+++++ Q A T L
Sbjct: 1240 ICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1299
Query: 5360 SRQIQKLAKDLTTI----LTKLKAKTDNV-VQAKTDQKVLGEELDGCNSKLMELDAAVQK 5414
+KL+++ + L + K K + + ++A+ +K L + + + E AAV++
Sbjct: 1300 KENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQ 1359
Query: 5415 FLEQNGQLGKPL--AKKIGKLTEL----HQQTIRQAENRLSKLNQAASHLEEYNEMLELI 5468
E ++ L + K +E H+Q I Q + S + E +E+ +
Sbjct: 1360 LEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQE-GDGKSAIGEEDEVNGNL 1418
Query: 5469 LKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI---DSELEAMTEKLQYLTSV 5525
L+ +V GT N Q ++ H+ ++ + + + + + EK S
Sbjct: 1419 LETDVDGQV---GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSP 1475
Query: 5526 YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
EK+ + + EL E + +++ ++++KF+A+ + + L+Q++ L
Sbjct: 1476 EEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELE 1535
Query: 5586 SPEVGR-------LSLKEQLSHRQHLLSEMESLKPKV----QAVQLCQSALRIPEDVVAS 5634
+ E G LK Q S + ++S L+ + ++ +S + V +
Sbjct: 1536 NLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDT 1595
Query: 5635 LPLCHAALRLQEEASRLQHTAIQQCNIM----QAAVVQYEQYEQEMKHLQQLIEGAHREI 5690
R + A+ + +CN++ + V +Y+ YE L
Sbjct: 1596 SATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL----------- 1644
Query: 5691 EDKPVATSNIQELQAQISRH--EELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVT 5748
+ +Q +A S+H E +A K Q Q+ + ++ + ++ + V
Sbjct: 1645 ------LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKA------LQGQISSQQVAVE 1692
Query: 5749 EVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEE------------SGEE 5796
+++ AE D G LLP + + GR L V E S ++
Sbjct: 1693 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 1752
Query: 5797 GT--------NSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS 5848
G N E S + P ++++I Q ++ + +A ++
Sbjct: 1753 GLDEMLDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINA--MNEKVK 1810
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
E +P S AK+ DL + + E + E + + +++ + + T +
Sbjct: 1811 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFL 1870
Query: 5909 EAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAE 5968
E L+E PG+ Q E L + + E+ SL +E+ S +D A
Sbjct: 1871 ETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKKHL-EVLHSLLKEISSHGLPSDKAL 1929
Query: 5969 QLALQSTLTVLAERMS-TIRMKASGKR---------QLLEEKLNDQLEEQRQEQALQRYR 6018
L + L+ + M TI+ K Q+L + L ++E ++ + +
Sbjct: 1930 VLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPS 1989
Query: 6019 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
A++L L TK + E + + N++ + A++ +V +
Sbjct: 1990 FGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIA--AVKSGG 2047
Query: 6079 LLLEGKAHTKDEAEQLAGK-LRRLKGSLLELQRALHDKQLNMQGTAQEKEE--SDVDLTA 6135
+L G+ + E A K L +K + ++ D L ++ E S +
Sbjct: 2048 AVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQ 2107
Query: 6136 TQSPGVQEWLAQARTTWTQQRQS-----------SLQQQKELEQELAEQKSLLRSVASRG 6184
+S + +WL + T T+ +Q+ ++Q K E EL + + ++ + +
Sbjct: 2108 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKL 2167
Query: 6185 EEILIQHSAAETSGDAGEKP---------DVLSQELGM-------EGEKSSAEDQMRMKW 6228
E+L E + D E P D QEL + E+SS
Sbjct: 2168 TELL------EENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTV 2221
Query: 6229 ESLHQEFSTKQKLLQNVL------------EQEQEQVL----------YSRPNRLLSGVP 6266
E+ +++ +++L+ +VL +++Q Q+L Y + G+
Sbjct: 2222 EAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL 2281
Query: 6267 LYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR---QSIHLEQKLYDGVSATSTWL 6323
G+ P+ + V L + Q ++ ++ Q Q+I + + + S L
Sbjct: 2282 SRPGEDPSL-RGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL 2340
Query: 6324 DDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVI 6383
D++ +L + A+ T NQ++ + + +K + +QA E+ V
Sbjct: 2341 SDLDNKLSSSLAV---STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSAL-VK 2396
Query: 6384 EDTLGCLLGRL--SLLDSV--VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
E+ L L R +L S V Q+ + LQ + + + ++ +K
Sbjct: 2397 EEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF--QAWLDTKK 2454
Query: 6440 LANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ------------ 6487
P++ +++ ++ K+F + +K E ++
Sbjct: 2455 EEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQ 2514
Query: 6488 -ELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIV 6546
+L+ ++ +D + R + L ++L +Y+ ++ L ++ Q + + +
Sbjct: 2515 LQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD 2574
Query: 6547 SSKEE--IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKE--TQFHTELMAQASAV 6602
++ E I +L KE Q +L T + + KE T + L+ + V
Sbjct: 2575 PAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMV 2634
Query: 6603 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIP---SVGLVEENEDRLIDRIT 6659
++ H + LE + + + E +E RQL+ + + S+G + L T
Sbjct: 2635 TEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL----T 2690
Query: 6660 LYQHLKSSLNEYQPKLYQVLDDGKRLLISIS----CSDLESQLNQLGECWLSNTNKMSKE 6715
+ Q + SL + ++ + L++ S SD+ Q+ + + + + ++ ++
Sbjct: 2691 MLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEK 2750
Query: 6716 LHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFS 6775
LET L+ +Q+ ++ D L+ V ++ E ++ F
Sbjct: 2751 CSFLETKLQGIGHFQNTIREMFSQFAEFDDELD----SMAPVGRDAETLQKQKETIKAFL 2806
Query: 6776 KEVDAQSSLKSSVLSTGNQLLRLKKV--DTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6833
K+++A + + T +L ++ D ++ +L + Q LL A +E++
Sbjct: 2807 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 2866
Query: 6834 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID----I 6889
+ +L + S++ + L++ + +E + + I++ L +K F+ + +
Sbjct: 2867 T-IKRLEEFY--SKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPL 2923
Query: 6890 NCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGL 6949
KQ V+++ Q ++Q +++ ++ + L +N W+ L V ++ L+
Sbjct: 2924 QGKQQDVNWLGQGLIQSAAKSTSTQGLE-----HDLDDVNARWKTLNKKVAQRAAQLQEA 2978
Query: 6950 LESWSEYENNVQCLKTWF-ETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE 7008
L +++ ++ L +W +T+E Q+ + V+ +++ + L+ L+ ++ VE
Sbjct: 2979 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3038
Query: 7009 KIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAF 7068
I++ G + + ++ L L W L + L+ +
Sbjct: 3039 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETL 3098
Query: 7069 DKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLK 7128
+ +N +L L + ++ Q+ + L+DD+ + L + SI Q LK
Sbjct: 3099 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLK 3157
Query: 7129 ECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQL--------------WQRYK 7174
+ + + + + W EI E+ S LLQ +
Sbjct: 3158 VLSSREDKDMVQSKLDFSQVW---YIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3214
Query: 7175 DYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND-LLKGLGTVK----DSL 7229
+ S + Q+ T L K + + +++ Q+ + LL GL +K D +
Sbjct: 3215 NEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3274
Query: 7230 FFLHELGEQLKQQ------VDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY 7283
+ + E +K + + A ++ L L++ L + + LC ++ +L Y
Sbjct: 3275 LIIQDKLEAIKARYKDITKLSTDVAKTLEQ-ALQLARRLHSTHEELCTWLDKVEVELLSY 3333
Query: 7284 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7343
ET ++L+G++ S + Q R +ELK + ++ LD LN
Sbjct: 3334 ET----------------QVLKGEEASQA------QMRPKELKKEAKNNKAL---LDSLN 3368
Query: 7344 ELGYRL----PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETW 7397
E+ L P +E K + N + L+S T++ ++ + +L+ Q F + +
Sbjct: 3369 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3428
Query: 7398 MEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQ 7455
+ ++ +TE+KL +I Q + + F E+ + I+ ++ G +++
Sbjct: 3429 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3488
Query: 7456 VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515
+++ KL + + + + +R ++ ++ E E+L WL E +
Sbjct: 3489 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI- 3547
Query: 7516 MSGLGSVPIPLQQARTLFDEVQFKEKV--FLRQQGSYILTVEAGKQLLLSADSGAEAALQ 7573
+ +P P + TL + + ++ + + +I + LL G
Sbjct: 3548 ---ISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG------ 3598
Query: 7574 AELAEIQEKWKSASM---RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7630
E IQEK+ +A +++E KK A L + D ++++ +++ + L
Sbjct: 3599 -EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3657
Query: 7631 DHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS-------AYISADDISI----L 7679
+ AE + KE + + + D+ +L L +TL A D I +
Sbjct: 3658 QP-PSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAV 3716
Query: 7680 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDIL 7739
++++ + WE + + R ++ + + F + L + + + D
Sbjct: 3717 QDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPG 3776
Query: 7740 IEEMIEKLKKD----YQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRW 7795
I+ + K +++ +EEI QE + +G L A E ++ + ++N W
Sbjct: 3777 IDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAW 3836
Query: 7796 QHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQR 7853
L R+ KL+E + A Q + ++ W+ +LA PI D E +++
Sbjct: 3837 DSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDL---ETVKQ 3893
Query: 7854 KLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNIC 7913
++ E ++ + + + + + + E+LL +++ ++Q L W ++
Sbjct: 3894 QIEELKQFKSEAYQQQIEMERLNHQAELLLKKV---TEESDKHTVQDPLMELKLIWDSLE 3950
Query: 7914 AMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
+ R+ K+E +F WL +E + G + EL K
Sbjct: 3951 ERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHV 4010
Query: 7974 FQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLK 8033
Q V + +E +NK L + + A +L+ + NQRW N+ ++ ++L
Sbjct: 4011 LQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLD 4070
Query: 8034 HFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIE 8093
+ Q + F + + WLT+ + L + AK +QL + + K E
Sbjct: 4071 GALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAK-EQLNVHMEVCAAFEAKEE 4129
Query: 8094 ---QIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8150
++ +G+Q++ + I+++++ L+ + V E
Sbjct: 4130 TYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESV-------------------ETK 4170
Query: 8151 LSDRELELEDSAALSDLHWHDRSADSL-LSPQPSSNLSLSLAQPLRSERSGRDTPASVDS 8209
L++R+ +LE++ L+ + +H+ D + Q L+++ L +D+
Sbjct: 4171 LNERKTKLEEALNLA-MEFHNSLQDFINWLTQAEQTLNVASRPSL-----------ILDT 4218
Query: 8210 IPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLT 8269
+ + D + ++ S + + D+ G K F + V L ++ + K+
Sbjct: 4219 VLFQIDEHKVFANEVNSHREQIIEL-DKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVV 4277
Query: 8270 ENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELD------TSYK 8323
+ ++ A + +Q +A ++++E + S+ + D +K
Sbjct: 4278 QRLVERGRSLDDA-RKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHK 4336
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ K LG S D+ R LKE+ + L + + + D+W+ + +++ +
Sbjct: 4337 EFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKL---DDMLSELRDKWDTICGKSVER 4393
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKA 8443
+ ++++ L QF L ++ WL E +L + Q + DI + I K QK
Sbjct: 4394 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVH--GDIDLVMNLIDNHKAFQKE 4451
Query: 8444 VDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8503
+ R + + ++ + E + +S ++ ++ +++ RW+ VC+L + L+ AL Q
Sbjct: 4452 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4511
Query: 8504 CQGFHEMSHGLLLMLENIDR--RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
+ FH + H LL L ++ R + ++P D + L D HK+ M+ +L E + +
Sbjct: 4512 AEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA-LRTLIDQHKEFMK---KLEEKRAEL 4567
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDL 8621
M +L K + +I R + +L +H + L L ++Q+L
Sbjct: 4568 NKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQEL 4627
Score = 295 bits (754), Expect = 2e-78
Identities = 767/4203 (18%), Positives = 1632/4203 (38%), Gaps = 605/4203 (14%)
Query: 4269 VTNLE-ELNVVQSRFQELMEWAEEQQPN-------IAEALKQSPPPDMAQNLLMDHLAIC 4320
+T LE E+NV + +QEL++ AE ++ I+E + ++ L+ +
Sbjct: 708 ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTP 767
Query: 4321 SELEAKQMLL------KSLIKDADRVMADLGLN----ERQVIQKALSDA----QSHVNC- 4365
E + + + L K+ +R+ DLG E Q A S + +S +N
Sbjct: 768 LERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVV 827
Query: 4366 ---LSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV 4422
++ + Y++K L L A + ++ +E K+ E + +++ +
Sbjct: 828 LQNMNQVYSMSSTYIDK-LKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
Query: 4423 KTCKSAQASLK-------TYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSV--YD 4473
T K ++ + ++E+ A E+ K E++ K + Q V +
Sbjct: 887 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQ 946
Query: 4474 SVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFP-EINLMNESSELHTQLA 4532
+V + +RL++LE S K++++ + W++Q + + N S L TQL
Sbjct: 947 NVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLN 1006
Query: 4533 KYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVA--LAKD 4590
+ + ++ + ++ + Q+ + ++ + + ++ + +Q + + +
Sbjct: 1007 QQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSS 1066
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILD 4650
+QE + R Y +L+ L TQ + R+ EE SL++ + ++
Sbjct: 1067 ADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE--------EEEKSLEEEKKEHVE 1118
Query: 4651 EVAGLGEAVDELNQKKEGFRSTGQP----------------WQPDKMLHLVTLY---HRL 4691
+ L + V +++ + G+P Q + L + L+ H
Sbjct: 1119 KAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD 1178
Query: 4692 KRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLA 4751
K E+R L + + + + + + +QL+ + EE + AE + + L
Sbjct: 1179 KMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQ 1238
Query: 4752 GSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESR 4811
G R+ H E + +K + + + Q +++ A+ E V E+
Sbjct: 1239 GICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENF 1298
Query: 4812 MVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSL-RIM 4870
+ ++ + ++ ++L ++ L + + + ++ + E+ + L +++
Sbjct: 1299 LKENGEKLSQEDKAL---------------IEQKLNEAKIKCEQLNLKAEQSKKELDKVV 1343
Query: 4871 NALSHKEKEKFTKAKELISAD--LEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYY 4928
+E EK K+L + +E+ L LS +D D + A + ++ Q ++
Sbjct: 1344 TTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHK----QVIEQNGTHF 1399
Query: 4929 QVFQAANDWLEDAQELLQLAGNGLD--VESAEENLKS--------HMEFFSTEDQFHSNL 4978
Q + E+ + L +D V + +ENL H + S
Sbjct: 1400 QEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIAT 1459
Query: 4979 EELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKA 5038
+ L+ + P KE L++ + L++ + +S ++ L + +
Sbjct: 1460 QSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDAD 1519
Query: 5039 REEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQL 5098
E + +E++L + KL K SF E +++ + +
Sbjct: 1520 YTEFEHWLQQSEQELENLEA-GADDINGLMTKLKRQK-------SFSEDVISHKGDLRYI 1571
Query: 5099 EKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQ 5158
+GN +A S S + T A ++ ++ L+ A D + +K +
Sbjct: 1572 TISGNRVLEAAKSCSKRDGGKVDTS--ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKD 1629
Query: 5159 LQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGE 5218
L DK Y D L Q+
Sbjct: 1630 LVDKYQ----------------HYEDASCGLLAGLQAC---------------------- 1651
Query: 5219 EPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNP 5278
E TA + ++ E + + K ++++L++ + ++ QI+S + V++ K+
Sbjct: 1652 ------EATASK----HLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKK---TA 1698
Query: 5279 TIEIDAQ------LEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQ--LA 5330
+ +DA+ ++Q L + +++ K E+ EK L L LS+Q L
Sbjct: 1699 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEK---LQITLTRSLSVQDGLD 1755
Query: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
E+ L ++ +KE Q S L I K N++
Sbjct: 1756 EM---LDWMGNVESSLKEQGQVPLNSTALQDIISK-----------------NIM----- 1790
Query: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNG-QLGKPLAKKIGKLTELHQQTIRQAENRLS 5449
L +++ G S + ++ V+KF+E L K+ L+ + + + L+
Sbjct: 1791 ---LEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 1847
Query: 5450 KLNQAASHLEEYNEMLELILKWIE-KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEI 5508
K+ + + +E + + E + ++E K + L + ++L QY+ T E E
Sbjct: 1848 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL-SQYMQEST--SEFLEH 1904
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMS---QQVAELGRETEELRQMIKIRLQNLQDAAKDMKK 5565
LE + L+ ++S + ++ L ++ +E+ IK + + + + +
Sbjct: 1905 KKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDA 1964
Query: 5566 FEAELKKLQAALEQA--QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQ---- 5619
F+ +K L++ +++ + + P G L + L + L + P++Q V
Sbjct: 1965 FQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGI 2024
Query: 5620 -LCQ--SALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM 5676
LC SA+ P +A++ A L + A+ + + + +
Sbjct: 2025 SLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKG--LTSIKKDMTDISHGY 2082
Query: 5677 KHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG----YQEQIASLNS--- 5729
+ L L++ E+ K S +Q+ Q + S + QK+ +Q+ A ++
Sbjct: 2083 EDLGLLLKDKIAELNTK---LSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2139
Query: 5730 KCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA--GRCHTL-- 5785
K ++ K+ A + V +V+ L + +L E TP A M+T + L
Sbjct: 2140 KTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2199
Query: 5786 LSPVTEESGEEGTNSE--------------ISSPPACRSPSPVANTDASVNQDIAYYQAL 5831
L+ ++ EE +N+ + P++ +N Q L
Sbjct: 2200 LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQIL 2259
Query: 5832 SAERLQTDAAKIHPSTSASQEFYE-PGLEPSATA----KLGDLQRSWETLKNVISEKQRT 5886
E T + T+A Q PG +PS +L + + W++L +S++
Sbjct: 2260 LQE-FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2318
Query: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMDEILMLQ 5943
+ +A+ + +YQ L+S+S K+ ++ KLS S P++ Q+ Q + EI +
Sbjct: 2319 IDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEK 2378
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
+I Q +L E+L + E +L+ Q L + + + KA Q L+
Sbjct: 2379 KQIKVAQ-ALCEDLSALVKEEYLKAELSRQ--LEGILKSFKDVEQKAENHVQHLQSACAS 2435
Query: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDM-----------EAQL 6052
+ Q+ + Q + E + A LD S K+ D E +
Sbjct: 2436 SHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTI 2495
Query: 6053 MDCQNMLVEIEQKVVALSELSVH---------------NENLL---LEGKAHTKDEAEQL 6094
+ +N+L++ + A +L ++ EN L LE K++ E L
Sbjct: 2496 AEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETL 2555
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + + +L E++ L E E S L + Q Q +
Sbjct: 2556 WPWIDKCQNNLEEIKFCL---------DPAEGENSIAKLKSLQKEMDQHF---GMVELLN 2603
Query: 6155 QRQSSLQQQKELEQELA--EQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELG 6212
+SL E+++E+ E KSL++ V E++ + E ++ +S+E
Sbjct: 2604 NTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKE-- 2661
Query: 6213 MEGEKSSAEDQMRMKWESLHQEFS--------TKQKLLQNVLEQ-------EQEQVLYSR 6257
+ + A++Q+ + Q +S T+QK LQ + Q Q+ V+ +
Sbjct: 2662 SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEAS 2721
Query: 6258 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVS 6317
++ S V L + + Q+ S ++ +D +F E Q G H + + + S
Sbjct: 2722 DSKGTSDV-LLQVETIAQEHSTLSQQVDE-KCSFLETKLQGIG------HFQNTIREMFS 2773
Query: 6318 ATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNL-----FSQA 6372
+ + D+++ + A + + ET +E + +K++ M N N A
Sbjct: 2774 QFAEFDDELD-----SMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLA 2828
Query: 6373 FPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK---VLFTSL 6429
E + I+ L L + + L R Q++ ++++ F + LK +L
Sbjct: 2829 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 2888
Query: 6430 ADNKYI---------ILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ 6480
+++ + + N+F+ E+IE +Q + + G+I+ + Q
Sbjct: 2889 EEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQ 2948
Query: 6481 VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAG 6540
+ +L + + L + R + L + L +++ AL+ L + E++
Sbjct: 2949 GLE---HDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM-VDTEELVA 3004
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQAS 6600
+QK + + ++ + + K + L+ E + R+ A E +++ Q S
Sbjct: 3005 NQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3064
Query: 6601 -------AVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDR 6653
A+L +A R +LE I E + L+ L +E + + + +
Sbjct: 3065 LLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASK 3124
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTN 6710
L ++I ++ L+ + + L+Q + G+ L + S D ++S+L+ ++
Sbjct: 3125 LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3184
Query: 6711 KMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLE-----------FWTQQSVTVPQ 6759
K L+ L + + + +L++WL D+L W QQS
Sbjct: 3185 KSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQS----- 3239
Query: 6760 ELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWT 6818
EL ++++ + L + VD L G +LL+ D ++ +L I +++
Sbjct: 3240 ELRVLQEDI---LLRKQNVD-------QALLNGLELLKQTTGDEVLIIQDKLEAIKARYK 3289
Query: 6819 D---LLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAI 6875
D L T++ E+ QL +L S H E+ +W+ +E + E +
Sbjct: 3290 DITKLSTDVAKTLEQALQLAR-RLHSTH--EELCTWLDKVEVELLSYETQV--------- 3337
Query: 6876 HEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD------KTDFAEQLGAMN 6929
L+ + + + K+L + N L S +V S + + + + N
Sbjct: 3338 ---LKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDN 3394
Query: 6930 KSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK-------QQHRIGD 6982
+ ++++ +T+K++ ++ + +++ +W EK+L +Q +
Sbjct: 3395 ERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSA 3454
Query: 6983 QASVQNA-----LKDCQDLEDLIK---------------AKEKEVEKIEQNGLALIQNKK 7022
Q VQ L+ ++DL+K + +K+++K+ +N + Q
Sbjct: 3455 QLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINS 3514
Query: 7023 EDVSSI--VMSTLRELGQTWANLDHMVGQLKILL--------------------KSVLDQ 7060
E + S + + +T+ L + + + ++ + + +
Sbjct: 3515 ERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLREL 3574
Query: 7061 WSSHKVAFDKINSYLMEARYSLSRFRLLTG---SLEAVQVQVDNL-QNLQDDLEKQERSL 7116
+ HK DK+N + L G S++ V D L +++D++K+ +L
Sbjct: 3575 IAEHKPHIDKMN------KTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVAL 3628
Query: 7117 QKFGSITNQLLKECHPPVTETLTNTLKEVNM--RWNNLLEEIAEQLQSSKAL---LQLWQ 7171
+ S + Q + + E+L ++ + + +E+I EQ+ +K + ++ Q
Sbjct: 3629 DEAISQSTQFHDKI-DQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQ 3687
Query: 7172 RYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATW-------------IQDCNDL 7218
+ KQ + + T++ + A +D D V W + D +L
Sbjct: 3688 PLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMEL 3747
Query: 7219 --------LKGLGTVKDSLFFLHELGEQ------LKQQVDASAASAIQSDQL-------- 7256
+ + T+KD+ F+ +L + +KQQ +A+ + D L
Sbjct: 3748 AEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVI 3807
Query: 7257 SLSQHLCA-----------------------LEQALCKQQTSLQAGVLDYETFAKSLEAL 7293
+L L A L +A + L+ + + L+A+
Sbjct: 3808 NLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAV 3867
Query: 7294 EAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYRLP 7350
W+ A L P +DL T+++++EELK + +++RLN EL +
Sbjct: 3868 FDWVDIAGGKLASMSPI-GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV 3926
Query: 7351 LNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7406
+ + +Q+ L W + + R KL+ LL F + + +L TE
Sbjct: 3927 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 3986
Query: 7407 KLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNL 7464
L+ + + G+ + + + H + Q ++ + Q + ++ G L+E ++
Sbjct: 3987 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4046
Query: 7465 KLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVS--YLPMSGLGSV 7522
KL +L+ +WQ V+ + +QR+ +D +RQ + + E L++WL + L LG +
Sbjct: 4047 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4106
Query: 7523 PIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEK 7582
P ++ + EV F ++ +Y ++ G+Q+L AE + ++ ++EK
Sbjct: 4107 PETAKEQLNVHMEVC---AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEK 4163
Query: 7583 WKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS-QSLPDHHEELHAEQM 7641
W+S +L E+K KL L + + D + L ++ L+ S P + Q+
Sbjct: 4164 WESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQI 4223
Query: 7642 -RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7700
K N V S + + +L L + D+ ++ + +Q +WE++ +L R
Sbjct: 4224 DEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVER 4283
Query: 7701 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK------KDYQEE 7754
+ + + F E +L EWL ES+ S + ++ I +K+K K++Q+
Sbjct: 4284 GRSLDDARKRAKQFHEAWSKLMEWLE--ESEKSLDSELEIANDPDKIKTQLAQHKEFQKS 4341
Query: 7755 IAIAQENKIQLQQMGERL-AKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
+ + G L K S +++ L ++ D+W + R KL+E L
Sbjct: 4342 LGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEAL 4401
Query: 7814 VAVQQLDKNMSSLRTWLAHIESELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
+ Q + +L WL +E +LA +P+ D + + ++ + Q+++ K ++
Sbjct: 4402 LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGD---IDLVMNLIDNHKAFQKELGKRTSS 4458
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
V ++ L+ + D+ +Q + L RW +CA+S+ ++ ++E R +
Sbjct: 4459 VQALKRSARELI---EGSRDDSSWVKVQM--QELSTRWETVCALSISKQTRLEAALRQAE 4513
Query: 7932 KFLDDYSRFEDWLKSSERTAAF----PSSSGVIYTVA---KEELKKFEAFQRQVHECLTQ 7984
+F +WL +E+T F P + T+ KE +KK E + ++++ T
Sbjct: 4514 EFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4573
Query: 7985 LELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNL-------QKRVTSILRRLKHFIG 8037
+ + DS ++K + R++ + Q+R+ S L L I
Sbjct: 4574 GDTV-------LAICHPDSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAGL---IA 4623
Query: 8038 QREEFETARDSILVWLTEMDLQLTN-----IEHFSECDVQAKIKQLKAFQQEISLNHNKI 8092
++E E ++L WL + LT+ I E +V+A I + + F +E++ +
Sbjct: 4624 KQELLE----ALLAWLQWAETTLTDKDKEVIPQEIE-EVKALIAEHQTFMEEMTRKQPDV 4678
Query: 8093 EQI 8095
+++
Sbjct: 4679 DKV 4681
Score = 284 bits (727), Expect = 2e-75
Identities = 728/3904 (18%), Positives = 1497/3904 (38%), Gaps = 443/3904 (11%)
Query: 4447 RELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHW 4506
+EL+K +E+ E + ++Y S ++ RL+ E L+ + + D
Sbjct: 723 QELLKSAEREEQEE------SVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDD---- 772
Query: 4507 LKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVD 4566
L ++ + L E L L N E+ Q + +P+L
Sbjct: 773 LHESVFRITEQEKLKKELERLKDDLGTITNKCEE--------FFSQAAASSSVPTLRS-- 822
Query: 4567 HSYLSEKLNALPRQFNVIVALAK---DKFYKVQEAILARKEYASLIELTTQSLSELEAQF 4623
+LN + + N + +++ DK V + + +L++L L E EA
Sbjct: 823 ------ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVI 876
Query: 4624 LRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGF----------RSTG 4673
+ + E +S R+ +DE + A+++ QK + R
Sbjct: 877 ADKNNI------ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLD 930
Query: 4674 QPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKV 4733
W +K LV + + Q + R+ LE + + + L+ ++ V+ Q K+
Sbjct: 931 FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990
Query: 4734 NEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGE 4793
+E P K +LA L +++ + + + +K Q + +
Sbjct: 991 -QENQPENSK-----TLATQLNQQKMLVSEIEMKQSKMDE------CQKYAEQYSATVKD 1038
Query: 4794 LKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDL--------N 4845
+L T V + V+ Q+ + ++ + V L +
Sbjct: 1039 YELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDS 1098
Query: 4846 LQDIQEEIRKIQIHQEE-VQSSLRIMNALSH-----KEKEKFTK---AKELISADLEHSL 4896
L+ ++EE + ++ ++E V+ + + +S+ K+ EK K +K+ IS++
Sbjct: 1099 LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSE----- 1153
Query: 4897 AELSELDGDIQEALRTRQATLT--------EIYSQCQRYYQVFQAANDWL-EDAQELLQL 4947
E+S + EAL+T Q L E ++ ++ + Q + + L ++ + LQ
Sbjct: 1154 -EISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQE 1212
Query: 4948 AGNGLDVESAEENLKSHMEFFSTEDQFHSNL--EELHSLVATLDPLIKPTGKEDLEQKVA 5005
+ DV+ E+ + + + + Q +L + + L+ + + G +L++
Sbjct: 1213 SQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKK--- 1269
Query: 5006 SLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDT--EKKLSEFSLLKTSS 5063
+ + + + +D L ++ K E + + E+KL+E +
Sbjct: 1270 -YQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1328
Query: 5064 SHEAEEKLSE-HKALVSVVNSFHEKIVA---LEEKASQLEK-------TGNDASKATLSR 5112
+ +AE+ E K + + + EK+ A LEE +++E D+ +A
Sbjct: 1329 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKH 1388
Query: 5113 SMT-----TVWQRWTRLRAVAQDQE---KILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5164
T +Q A+ ++ E +LE VD +V E ++Q K+
Sbjct: 1389 KQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVD------GQVGTTQENLNQQYQKV- 1441
Query: 5165 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPL-- 5222
KA+ ++ H ++ QSA +L +Q G +P E+ L
Sbjct: 1442 --------KAQHEKIISQHQAVIIAT---QSAQVLLEKQ-------GQYLSPEEKEKLQK 1483
Query: 5223 -MQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE 5281
M+E+ + L EK +++EL E + + W+Q++++ L N
Sbjct: 1484 NMKELKVHYETALAESEKKMKLTHSLQEEL---EKFDADYTEFEHWLQQSEQELEN---- 1536
Query: 5282 IDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQ 5341
++A +++ L+T+ + E + + + L TI + ++ E A RD
Sbjct: 1537 LEAGADDINGLMTKLKRQKSFSEDVISHKGD--LRYITISGN----RVLEAAKSCSKRDG 1590
Query: 5342 IQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5401
+V+ S AT +E+ R++ ++ +K +N+ + + G
Sbjct: 1591 -----GKVDTS-ATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL 1644
Query: 5402 NSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEY 5461
+ L +A K L + + ++ + T+ Q I + + KL + A L +
Sbjct: 1645 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDA 1704
Query: 5462 NEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521
L I+K G S S + E+ Q L S + L+ M L +
Sbjct: 1705 RGSLLPAKNDIQKTLDDIVGRYEDLSKS-VNERNEKLQITLTRSLSVQDGLDEM---LDW 1760
Query: 5522 LTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQ 5581
+ +V + K QV + L+ +I + QD A A +K++ +E
Sbjct: 1761 MGNVESSLKEQGQVP---LNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTD 1817
Query: 5582 -ATLTSPEVGRLSLKEQLSHRQH----LLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+T +S + L + S H L++ME LK KV+ + + E + L
Sbjct: 1818 PSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFE------NLSEKLQTFLE 1871
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE--GAHREIEDKP 5694
AL + + T + Q MQ + ++ ++++ ++ L L++ +H DK
Sbjct: 1872 TKTQALT-EVDVPGKDVTELSQ--YMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKA 1928
Query: 5695 VATSNIQELQAQISRHE----ELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEV 5750
+ L + E E + + QEQ+ + K L K T + + +
Sbjct: 1929 LVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQP 1988
Query: 5751 EGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRS 5810
+ G EDL L T + T ++ NS IS +
Sbjct: 1989 ---SFGAEDLGKSLEDTKKLQEKWSLKTP-------------EIQKVNNSGISLCNLISA 2032
Query: 5811 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQ 5870
+ A A+V A L+ E T+ ++EF+ S + D+
Sbjct: 2033 VTTPAKAIAAVKSGGA---VLNGEGTATN----------TEEFWANKGLTSIKKDMTDIS 2079
Query: 5871 RSWETLKNVISEKQRTLYEALERQQKYQDSLQSIST---KMEAIELKLSESPEPG--RSP 5925
+E L ++ +K L L + QK Q+ ++ KM K ++P P +
Sbjct: 2080 HGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAV 2139
Query: 5926 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 5985
++Q+ ++++ E+ +++ EL+ L E L+ E+ D E + LT + +
Sbjct: 2140 KTQVEQNKSFEAELKQNVNKVQELKDKLTE-LLEEN--PDTPEAPRWKQMLTEIDSKWQE 2196
Query: 5986 IRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK-E 6044
+ ++Q LEE N+ + Q E L++ WL+ K + + L P +
Sbjct: 2197 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ----------WLVE-KELMVSVLGPLSID 2245
Query: 6045 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEG------KAHTKDEAEQLAGKL 6098
P + Q Q +L E + +L+ + +L + K++ + K
Sbjct: 2246 PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKW 2305
Query: 6099 RRLKGSLLEL-----QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ---EWLAQART 6150
L G L + Q + Q + + SD+D + S V + + Q
Sbjct: 2306 DSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLE 2365
Query: 6151 TWTQQRQSSLQQQKELE--QELAEQKSLLRSVASRGEEILIQ-HSAAETSGDAGEKPDVL 6207
T + +Q Q++K+++ Q L E S L E+ Q ++ D +K +
Sbjct: 2366 TAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENH 2425
Query: 6208 SQELGMEGEKSSAEDQMR---MKWESLHQE-------FSTKQKLLQNVLEQEQ------- 6250
Q L S QM W +E S K +L+++++ +
Sbjct: 2426 VQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2485
Query: 6251 ------EQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ 6304
E+ + N LL K + Q + T+ D N+ +E ++ ++
Sbjct: 2486 AQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW-DTFNKQVKERENKL----KE 2540
Query: 6305 SIHLEQKLYDGVSATSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKEMSEEMD 6363
S+ K + V W+D + L + L P E E + + L K++ + ++
Sbjct: 2541 SLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVE 2600
Query: 6364 KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK 6423
N + +++V+ D L+ ++ ++ ++ + ++ Q+ FQ K
Sbjct: 2601 LLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSK 2660
Query: 6424 V-----------------LFTSLADNKYIILQKLANVFEQPVAEQIEAIQQ-AEDGLKEF 6465
L + NKY+ + + Q + Q++ ++ A+D + E
Sbjct: 2661 ESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEA 2720
Query: 6466 DAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGL----NQNLTLKSQYE 6521
+ K D L + QE S L DE + ++ G+ N + SQ+
Sbjct: 2721 S----DSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 2776
Query: 6522 RALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESH------MILTET 6575
+L + G+ D + + KE I+ L K + ++ M+ TE
Sbjct: 2777 EFDDELDSMAPVGR-----DAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEE 2831
Query: 6576 LFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL----ETWSHLDEDQQELS 6631
++ E L Q + +L RA R ++E + E +S L E L
Sbjct: 2832 TSPDLVGIKRDLEA-----LSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQ 2886
Query: 6632 RQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISI-- 6689
+ E ES P VG+ E ++ ++ ++Q K + Q K V G+ L+ S
Sbjct: 2887 KAEEHEESQGP-VGMETETINQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQSAAK 2943
Query: 6690 --SCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL 6747
S LE L+ + W + K+++ +L+ L H R+Q L+ W+ ++ +
Sbjct: 2944 STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELV 3003
Query: 6748 EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKK-VDTATL 6806
S E ++V+ + + +D + S + G ++ + D +
Sbjct: 3004 ANQKPPSA----EFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI 3059
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
+LS +DS+W LL +L + + + + W++ +E + E
Sbjct: 3060 LKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP-- 3117
Query: 6867 KNSIGYKA--IHEYLQKYKGFKIDI---NCKQLTVDFVNQSVLQISSQDVESKRSDKTDF 6921
IG +A + E + ++K + DI N + QS+ +SS++ + K DF
Sbjct: 3118 ---IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3174
Query: 6922 AEQLGAMNKSWQI-LQGLVTEKIQLLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHR 6979
++ W I +Q + +LL+ L + + E+ V+ + E +K K +
Sbjct: 3175 SQV-------WYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ 3227
Query: 6980 IGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQT 7039
+ + + L++ I +++ V++ NGL L++ D I+ L +
Sbjct: 3228 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3287
Query: 7040 WANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF--RLLTGSLEAVQV 7097
+ ++ + + L+ L +++ ++L + L + ++L G EA Q
Sbjct: 3288 YKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGE-EASQA 3346
Query: 7098 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIA 7157
Q+ + L+ + + + L +++ LL+ E L + E N R+ + + I
Sbjct: 3347 QM-RPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3405
Query: 7158 EQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCND 7217
++++ A + Q++ + S + + E + L +D ++ +
Sbjct: 3406 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3465
Query: 7218 LLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQ 7277
+L+ + D + H++ ++ S + L +C + Q Q
Sbjct: 3466 ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDK-VLKNYDTICQINSERYLQLERAQ 3524
Query: 7278 AGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAP 7337
+ V F ++ E L W+ E + I+ Q P+ + + T++++ EE + + P
Sbjct: 3525 SLV---NQFWETYEELWPWLTETQSIIS-QLPAPALEYETLRQQQEEHRQLRELIAEHKP 3580
Query: 7338 DLDRLNELGYRL-PLNDKEIKRMQN----LNRHWSLISSQTTERFSKLQSFLLQHQTFLE 7392
+D++N+ G +L L+ E +Q + +S I +R L + Q F +
Sbjct: 3581 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3640
Query: 7393 KCETWMEFLVQTEQKLAV--EISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRL 7450
K + +E L + ++L IS + + EQ ++ +M Q + ++ G+ +
Sbjct: 3641 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700
Query: 7451 LEQGQVDDRD----EFNLKLTLLSNQWQGVIRRAQQRRG----IIDSQIRQWQRYREMAE 7502
+ + D+D KL + W+ + ++R +++ + W + +
Sbjct: 3701 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 3760
Query: 7503 KLRKWLVEVSYLPMSGLGSVPIPLQQ--ARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL 7560
++ + L G+ + QQ A T+ +E+ Q + + G +L
Sbjct: 3761 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-------GLQEELDIVINLGSEL 3813
Query: 7561 LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK-------------DWEKC 7607
+ + + ++ + E+ W S + +++ KL ++ DW
Sbjct: 3814 IAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDI 3873
Query: 7608 EKGIADSLEKLRTFKKKLSQSLPDHHE---ELHAEQMRCKELENAVGSWTDDLTQLSLLK 7664
G S+ + T + + Q + + + E + +Q+ + L + Q LL
Sbjct: 3874 AGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNH----------QAELL- 3922
Query: 7665 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7724
L D + + + L+ W+ L ++ R+ ++ L F EL W
Sbjct: 3923 --LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAW 3980
Query: 7725 LTQMESKVSQN----GDILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKASHES 7779
LT E +S+ GD E IE K + +A ++ ++ + + G L ++S
Sbjct: 3981 LTHTEGLLSEQKPVGGDPKAIE-IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGE 4039
Query: 7780 KASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-- 7837
+AS ++ KL +N RWQ++L+ R ++L L + + L+ WL E L
Sbjct: 4040 EASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLA 4099
Query: 7838 AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDS 7897
+KP+ E + +LN E+ E S++ + +L C A +
Sbjct: 4100 SKPL---GGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAET----N 4152
Query: 7898 IQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSS 7957
I Q NL +W ++ ER+ K+EE L +F + F +WL +E+T S
Sbjct: 4153 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4212
Query: 7958 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR 8017
+I ++ + + F +V+ Q+ ++K L ++ +K ++ R
Sbjct: 4213 SLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSR 4272
Query: 8018 WDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-VQAKI 8075
W+ + +R+ R L + ++F A ++ WL E + L + +E ++ D ++ ++
Sbjct: 4273 WEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQL 4332
Query: 8076 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAI-IEEELDELRRYCQEVFGR-VE 8133
Q K FQ+ + H+ + G L EK+ D + +++ L ELR + G+ VE
Sbjct: 4333 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4392
Query: 8134 RYHK 8137
R +K
Sbjct: 4393 RQNK 4396
Score = 278 bits (712), Expect = 1e-73
Identities = 768/4289 (17%), Positives = 1650/4289 (38%), Gaps = 539/4289 (12%)
Query: 1285 HQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQV 1344
HQQ + ++ D + ++Q G + +E+ + L +S ER+E+ V
Sbjct: 679 HQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESV 738
Query: 1345 ------TLRKWE-RFETNKETVVRYL---FQTGSSHERFLSFSSLESLSSELEQTKEFSK 1394
+R R E ++ ++R + + HE + E L ELE+ K+
Sbjct: 739 YNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKD--- 795
Query: 1395 RTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTK 1454
+I + E +A+ P + L +++ QV + T + +KT+ +V
Sbjct: 796 DLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMN-QVYSMSSTYIDKLKTVNLVLKN 854
Query: 1455 WDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEA 1514
+ + + E+E A+ + ++ IS +K E++ K LE+E
Sbjct: 855 TQAAEALVKLYETKLCEEE----AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL 910
Query: 1515 Q-----SFAQFVTTGES----------------------ARIKAKLTQIRRYGEELREHA 1547
Q S F T E +I +L + G+ L+ +
Sbjct: 911 QKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYR 970
Query: 1548 QC---LEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMD 1604
L+ I Q+ E RKIQ++ E LA + ++ Q MD
Sbjct: 971 DTYHPLDDWI-------QQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMD 1023
Query: 1605 LCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664
CQ SA K + A QQ + RR Q++ + ++ +
Sbjct: 1024 ECQKYAEQYSATV-------KDYELQTMTYRAMVDSQQKSPVKRR--RMQSSADLIIQEF 1074
Query: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVK-VEGELQLIQALQNEVVSQASFYSKL 1723
L ++ +T + + + + D +K +E E + ++ + E V +A K
Sbjct: 1075 MDLRTRYTALVTLM--------TQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA----KE 1122
Query: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
LQ S S KD K K P ++I+ + + + +Q E L +
Sbjct: 1123 LQKWVSNISKTLKDAEKAGK-------------PPFSKQKIS-SEEISTKKEQLSEALQT 1168
Query: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
I+LFL+ +H D + E + EL+ L + +L +
Sbjct: 1169 ----IQLFLA------------------KHGDKMTDEE--RNELEKQVKTLQESYNLLFS 1204
Query: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNS 1903
E L LQ +++ + E V ER+Q + L GI L QT
Sbjct: 1205 ESLKQLQ-ESQTSGDVKVEEKIVAERQQ----------EYKEKLQGICDLLTQT------ 1247
Query: 1904 MNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLC 1963
E+ LI Q A + V L SK + E + + +A L
Sbjct: 1248 ----ENRLI------GHQEAFMIGDGTVELKKYQSKQE--------ELQKDMQGSAQALA 1289
Query: 1964 GEVERIQNLL---GTKQSEADALAVLKKAFQDQK---EELLKSIEDIEERTDK---ERLK 2014
V+ +N L G K S+ D A++++ + K E+L E ++ DK +K
Sbjct: 1290 EVVKNTENFLKENGEKLSQEDK-ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIK 1348
Query: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKD----------KAKQIAQKD-------- 2056
E T +++ QLE+ E+ L WL + K KQ+ +++
Sbjct: 1349 EET-----EKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGD 1403
Query: 2057 --VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASS 2114
A E + N LE D EN L ++YQ +K+ K++ +
Sbjct: 1404 GKSAIGEEDEVNGNLLETDVDGQVGTTQEN---------LNQQYQKVKAQHEKIISQHQA 1454
Query: 2115 VIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLD-NFTSKGKHLLSELKKIHSSDFSL 2173
VI+ + + + + + E K K+ K+L ++ + ++K HS L
Sbjct: 1455 VIIATQSAQVLLEKQGQYLSPE-EKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEEL 1513
Query: 2174 VKTDMEST-VDKWLDVSEKLEEN-----------MDRLRVSLSIWDDVLSTRDEIE--GW 2219
K D + T + WL SE+ EN M +L+ S +DV+S + ++
Sbjct: 1514 EKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITI 1573
Query: 2220 SNNCVPQMAENISNLD-NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETP 2278
S N V + A++ S D + +E + ++ + R L+SK N L K
Sbjct: 1574 SGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLK----- 1628
Query: 2279 PDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCA 2338
DL+ K +H + + + G L A K +++ K
Sbjct: 1629 --------DLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPIAVDPK--------- 1668
Query: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQENLNSL--CRKYHSAELESLGRAMTGLIKKH 2396
L++ K +Q ++ SQQ + ++ L R + + + ++ ++
Sbjct: 1669 --NLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 1726
Query: 2397 EAVSQLCSKTQASLQESLEKHFS--ESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
E +S+ ++ LQ +L + S + + E +W +++ KE +S L+ +
Sbjct: 1727 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 1786
Query: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
+ ++ QS ++A+ ++ + SS+Q ++ + F + +
Sbjct: 1787 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 1846
Query: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNT-----ENLGESKQHIPEKKNEV--HKV 2567
+++ +++ FE+ KL ++ + +++ E Q++ E +E HK
Sbjct: 1847 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHKK 1906
Query: 2568 EM-FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSC 2626
+ L LL S S + +L + + S+ ++ ++ KE + SC
Sbjct: 1907 HLEVLHSLLKEISSHGLPSDKALVLEKTNN--------LSKKFKEMEDTIKEKKEAVTSC 1958
Query: 2627 QVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRL---SQIQDILLMKGE 2683
Q L + L ++L+S W+K ++ + + G++D L K L ++Q+ +K
Sbjct: 1959 QEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAED-LGKSLEDTKKLQEKWSLKTP 2014
Query: 2684 GEVKLN----------MAIGKGEQALRSSNKEGQRVIQTQ--LETLKEVWADIMSSSVHA 2731
K+N A+ +A+ ++ K G V+ + +E WA+ +S+
Sbjct: 2015 EIQKVNNSGISLCNLISAVTTPAKAI-AAVKSGGAVLNGEGTATNTEEFWANKGLTSIKK 2073
Query: 2732 QST-------------------LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ-PQP 2771
T L + +S+ E + + QW++ +++ Q P P
Sbjct: 2074 DMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAP 2133
Query: 2772 GLKEKF-VLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQE---ELKTQ 2827
E ++ +S +E + + + L K EL E+ D ++ E+ ++
Sbjct: 2134 TDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK 2193
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
+ ++ + ++ +K+EE + + + WL + + +S D + +
Sbjct: 2194 WQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQR 2253
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTA-SGCELMHTEMQALRADWKQWEDSVFQ 2946
+++ L L + P+ +Q T A G E +LR K+ +V Q
Sbjct: 2254 QQVQIL----------LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQ 2303
Query: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQAL---EQFSALLKTWAQQLTLLEGKNTDEEIV 3003
L + S + ++QA+ Q+ +LL++ + +L+ L+ K + V
Sbjct: 2304 KWDSLTG----------QLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2353
Query: 3004 ECWHKG-QEILDALQKAEPRTEDLKSQLNELCRFSRDLST----------YSGKVSGLIK 3052
+ L+ QK + + K Q+ DLS S ++ G++K
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2413
Query: 3053 EYNCLCLQASKGCQNKEQIL--QQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS 3110
+ + +A Q+ + +F++ RDFQ WL K K I + + +
Sbjct: 2414 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2473
Query: 3111 LQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQ 3170
++ ++F H +++GE L + +Q ++ K +W F+ + +
Sbjct: 2474 IKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKE 2533
Query: 3171 KESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEI 3230
+E+ L+ + ++ E + W+ K + + E L D KL+S+ +E+
Sbjct: 2534 RENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCL-DPAEGENSIAKLKSLQKEM 2592
Query: 3231 HCYEPQLNRLKEKAQQLW------------EGQAASKSFRHRVSQLSSQYLALSNLTKEK 3278
+ + L A L E ++ + QL S+ L N+T +K
Sbjct: 2593 DQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMT-QK 2651
Query: 3279 VSRLDRIVAEHNQFSLGIKELQDWMTDAIH-MLDSYCHPTSDKSVLDSRTLKLEALL-SV 3336
+ E + KE D IH L S + ++L ++ L+AL V
Sbjct: 2652 FKEFQEVSKESKRQLQCAKEQLD-----IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQV 2706
Query: 3337 KQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALS 3396
K + ++V +S +G + Q++++ ++L S LE L
Sbjct: 2707 DLAKRLAQDLVVEASDS-------KGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQ 2759
Query: 3397 KWTSYQDGVR----QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSL 3452
+Q+ +R QF+ + D +++ + K T+ K L + S +
Sbjct: 2760 GIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNA 2819
Query: 3453 LETIEVKGAGMTEHYVTQL-----ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRD 3507
+T ++ A TE L +L+ L ++ + +RA+ + E ++ +E+
Sbjct: 2820 NKTCKMMLA--TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSK 2877
Query: 3508 LKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAE------------GQAL 3555
LK F + L + +E + + + T L + Q E GQ L
Sbjct: 2878 LKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGL 2937
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ S S Q + L+ + W+ ++++ Q + + +
Sbjct: 2938 IQS-------AAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALE 2990
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
+ W+ EE +++ + +V + + Q++L + + + + A
Sbjct: 2991 SLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATT 3050
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
+ +++K L +++ L+ +L + ++ + VA + +TL
Sbjct: 3051 AEPADKVKIL-KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFH-----------ETL 3098
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEE-GEAERLRKEIHDHMEQLKELTSTVRKEHM 3794
E L + + L + G +A K E+ + + L +I +H + L H
Sbjct: 3099 EPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHL----------HQ 3148
Query: 3795 TLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSH 3854
+ G L S + K + Q ++ ++ ++ E+ EK S+ + LQQ +
Sbjct: 3149 AVSIGQSLKVLSSREDKDMVQSKLDFSQVWYI------EIQEKSH--SRSELLQQALC-- 3198
Query: 3855 EPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIG--------KAMMEEIAGFE 3906
+ K E L+ + +V DK+ +L QD + G + + E+I +
Sbjct: 3199 --NAKIFGEDEVELMNWLNEV--HDKLSKL--SVQDYSTEGLWKQQSELRVLQEDILLRK 3252
Query: 3907 DRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQK 3966
++ + G L+ Q ++ + A KD A+ + Q+L+ +
Sbjct: 3253 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3312
Query: 3967 HVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMC 4026
H T ++ WL V+ +L L EA + + L+++A+ LL S+
Sbjct: 3313 H----STHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3368
Query: 4027 DLSNASVKTTAKDIQQ-----TEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQ 4081
++S+A ++ ++ + E+ + + +TQ EEI + Q AD +
Sbjct: 3369 EVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAE 3428
Query: 4082 L----QNMKRRHSELELNIAQNMVS---QV-KDFVKKLQSKQASVNTIIEKVNKL----T 4129
L + K+ S ++ + Q+ S QV K F ++ + ++ +++ +K+ +
Sbjct: 3429 LSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACS 3488
Query: 4130 KKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEW 4189
++E+ K+++ + + +C+ ++ LQ E ++V F E + W
Sbjct: 3489 EEEKQSMKKKLDKVLKNYDTICQINSERYLQLER----------AQSLVNQFWETYEELW 3538
Query: 4190 DNLARSDAESTAVHLEALKKLALALQERKY-AIEDLKDQKQKMIEHLNLDDKELVKEQTS 4248
L + + + + AL+ L Q+ ++ + +L + + I+ +N +L++
Sbjct: 3539 PWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPG 3598
Query: 4249 H---LEQRWFQLEDL---IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQ 4302
+++++ + L IK ++ L+E ++F + ++ E I E L+Q
Sbjct: 3599 EGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQ 3658
Query: 4303 SP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
P + + + ++ + ++E Q L ++L + + ++A G ++ + KA+ D
Sbjct: 3659 PPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQD 3718
Query: 4359 AQSHV----NCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
+ + LV +R L + +F I+ + I E +
Sbjct: 3719 KLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGID 3778
Query: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
P V +Q + ++ + + Q E+ + G EL+ E +K V + EL S +DS
Sbjct: 3779 PSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDS 3838
Query: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT---QL 4531
+ + R+ +LE+ + + +++ W+ DI ++ ++L T Q+
Sbjct: 3839 LNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWV---DIAGGKLASMSPIGTDLETVKQQI 3895
Query: 4532 AKYQNILEQSPEYENLLLTLQRTGQTILPSL-NEVDHSYLSEKLNALPRQFNVIVALAKD 4590
+ + ++ + + + L + +L + E D + + L L ++ + +
Sbjct: 3896 EELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955
Query: 4591 KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTD-LAVEEALS----LQDGC 4645
+ +K++ A+LA ++ ++ L+ E V D A+E L+ LQ+
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDT 4705
A V + +A ++L + G ++ +K+ L + + +TEQR L+
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGA 4072
Query: 4706 TSAYQEHEKMCQQLERQLKSVKEE---QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLK 4762
+ + L++ L + + A+E+L ++ + + + K
Sbjct: 4073 LRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYK 4132
Query: 4763 RVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEM 4822
+ + + A I + + + + + + + E T+ E + +++F +
Sbjct: 4133 SLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4192
Query: 4823 SRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL--SHKEKEK 4880
++WL + + L+ L L + +I + ++ EV S + L + +
Sbjct: 4193 QDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKY 4252
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
F++ ++++ +++ L + + + L R +L + + +++++ + +WLE+
Sbjct: 4253 FSQKQDVVL--IKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEE 4310
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD----PLIKPTG 4996
+++ L + L++ + + +K+ + + +F +L HS+ T + L + T
Sbjct: 4311 SEKSLD---SELEIANDPDKIKTQL---AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTS 4364
Query: 4997 KED----LEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKK 5052
D L+ ++ L + + S + + L+ + A + +I+ + E +
Sbjct: 4365 LADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQ 4424
Query: 5053 LSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSR 5112
L+E + + HKA + + AL+ A +L + D S + +
Sbjct: 4425 LAEDQPVH-GDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDS-SWVKV 4482
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
M + RW + A++ ++ LE A+ + F++ V E + + + L
Sbjct: 4483 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4542
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
+ L TL++ H F+ +LE++++ L ++L A P + IT ++ R
Sbjct: 4543 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVL---AICHPDSITTIKHWITIIRAR 4599
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQ--------ETKEYLGNPTIEIDA 5284
+ K + + + L + + ++ W+Q + KE + E+ A
Sbjct: 4600 FEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKA 4659
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEK 5313
+ E Q + E T + +++K+ + K +
Sbjct: 4660 LIAEHQTFMEEMTRKQPDVDKVTKTYKRR 4688
Score = 276 bits (707), Expect = 5e-73
Identities = 777/4352 (17%), Positives = 1650/4352 (37%), Gaps = 709/4352 (16%)
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQ----ADEMDRMKKEYTDCVVTL-----SAFATEAHK 736
++QQ + W E + +K +E+DR++ + T+ +
Sbjct: 629 IEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQS 688
Query: 737 KLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
+ + LE S + D+ +E+ V V Y+ + K+A +E +E ++ +
Sbjct: 689 RFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAE---REEQEESVYNLY--I 743
Query: 797 SKLKEQLTKVKECYSPL------------LYESQQLLIPLEELEKQMTSFYDSLGKINEI 844
S+++ +++ C L L+ES + E+L+K++ D LG I
Sbjct: 744 SEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNK 803
Query: 845 ITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD---- 900
+A +S+ EL +N + ++ S + K T++ VLK+
Sbjct: 804 CEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSM---SSTYIDKLKTVNLVLKNTQAAEA 860
Query: 901 -----QTRLQRQ---IADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRI 952
+T+L + IAD + ++++ W+ V+ ++ E+ EL+K I
Sbjct: 861 LVKLYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALED---ELQKAKAI 916
Query: 953 AQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDI--------LPEQEQQGL 1004
+ E + + + H E QL +R N ++ + L D+ L
Sbjct: 917 SDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPL 976
Query: 1005 QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLAS-VEECRTELDRETKLMPQEGS-- 1061
+ ++++ + +Q P + L + + + L S +E ++++D K Q +
Sbjct: 977 DDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATV 1036
Query: 1062 ---EKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVK--LPVRDPVRDTPGTCHVTL--KE 1114
E +R + + +R+Q +L ++ + +R T T VTL +
Sbjct: 1037 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLR-----TRYTALVTLMTQY 1091
Query: 1115 LRAAIDSTYRKLMEDP---DKWKDYTSRFSEFSSWISTNETQLKG-------------IK 1158
++ A DS R E+ ++ K++ + E W+S LK I
Sbjct: 1092 IKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKIS 1151
Query: 1159 GEAIDT----------------ANHGEVKRAVEEIRNGVTKRGETLS-----WLKSRLKV 1197
E I T A HG+ + +E RN + K+ +TL LK
Sbjct: 1152 SEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERNELEKQVKTLQESYNLLFSESLKQ 1209
Query: 1198 LTEVSSENEAQKQGDELAKLSSSFK----ALVTLLSEVEKMLSNF--------------- 1238
L E + + + + +A+ +K + LL++ E L
Sbjct: 1210 LQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKK 1269
Query: 1239 -------------GDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEA----QQL 1281
G E+VKN+ E + + E Q +K L + L EA +QL
Sbjct: 1270 YQSKQEELQKDMQGSAQALAEVVKNT-ENFLKENGEKLSQEDKALIEQKLNEAKIKCEQL 1328
Query: 1282 LLHHQQKTKR----ISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRER 1337
L +Q K ++ ++ +++A +Q E E K+E+ LD L +
Sbjct: 1329 NLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE--------ESKTKIENLLDWLSNVDKD 1380
Query: 1338 QER----RIQVTLRKWERFETN--------KETVVRYLFQTGSSHERFLSFSSLESLSSE 1385
ER QV + F+ ++ V L +T + ++ E+L+ +
Sbjct: 1381 SERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQ---VGTTQENLNQQ 1437
Query: 1386 LEQTKEFSKRTES------IAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439
++ K ++ S IA Q+ ++ E L P+ K+ LQ+ K +K +
Sbjct: 1438 YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1497
Query: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK----- 1494
E+ +K ++ + + F +++ W+ + E+EL LE + ++ ++++K
Sbjct: 1498 ESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSF 1557
Query: 1495 ---VTIQEIESKLSSIVG--LEEEAQSFA-----QFVTTGESARIKAKLTQIRRYGEELR 1544
V + + + +I G + E A+S + + T+ ++ KL L
Sbjct: 1558 SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSLY 1617
Query: 1545 EHAQCLEGTILGHLSQQQKFEE-------NLRKIQQSVSE-FEDKLAVPIKICSSATETY 1596
L + + + Q +E+ L+ + + S+ + +AV K E
Sbjct: 1618 SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQRQLEET 1677
Query: 1597 KVLQEHMDLCQ-ALESLSSAITAFSASARKVVNRDSCVQEAA-ALQQQYEDILRRAKERQ 1654
K LQ + Q A+E L + ++ + +Q+ + +YED+ + ER
Sbjct: 1678 KALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERN 1737
Query: 1655 TALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVV 1714
L+ L ++ L L W+ E+ +K +G++ L +++
Sbjct: 1738 EKLQITLTRSLSVQDGLDEMLDWMGNVESS------------LKEQGQVPLNSTALQDII 1785
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKMMKL----HLEQLDERWRDLPQIINKRINFLQSV 1770
S+ + + ++S + ++ K M+ L + +DL ++ + +
Sbjct: 1786 SKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKET 1845
Query: 1771 VAEHQQFD---ELLLSFSVWIKLFL-SELQTTSEISIMDHQVA-LTRH-KDHAAEVESKK 1824
+A+ ++ EL + S ++ FL ++ Q +E+ + V L+++ ++ +E K
Sbjct: 1846 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLEHK 1905
Query: 1825 GELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSH 1884
L+ L L ++ S G D L+ K + + F+E ++ ++ A++ E L +
Sbjct: 1906 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 1965
Query: 1885 ASLSGILRQLRQTV-EATNSMNKNESDLIEKDLNDALQNAKALE--------------SA 1929
L ++ L+ + E T + + +DL +L++ K L+ ++
Sbjct: 1966 QVL---VKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNS 2022
Query: 1930 AVSLDGILS------KAQYHLKIG-----------------SSEQRTSCRATADQLCGEV 1966
+SL ++S KA +K G +++ TS + +
Sbjct: 2023 GISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGY 2082
Query: 1967 ERIQNLLGTKQSEADA-LAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPT-RQALQQ 2023
E + LL K +E + L+ L+KA Q++ +++ ++ + + K ++ PT +A++
Sbjct: 2083 EDLGLLLKDKIAELNTKLSKLQKA-QEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKT 2141
Query: 2024 RLRVFNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRLI 2081
++ E EL + +++ LKDK ++ ++ D AP + + ++ W + +L
Sbjct: 2142 QVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLT 2201
Query: 2082 HENQGQCCGLIDLMREYQNLKSAVSK-VLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ Q + + + ++Q +++ + + ++E V V D L + +
Sbjct: 2202 IDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQ 2261
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLR 2200
+ ++ + T+ G+ +LS + S +VK + + KW ++ +L + D +
Sbjct: 2262 EFATRKPQYEQLTAAGQGILSRPGE-DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWID 2320
Query: 2201 VSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE--------------ELLKE 2246
++ V ST+ + + + +++ +S+LDN L + E ++
Sbjct: 2321 QAI-----VKSTQYQ------SLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2369
Query: 2247 FESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLE----HAKEITEVA 2302
+ E++ + +++ + DL L K ++++A+L ++LE K++ + A
Sbjct: 2370 MKQEIQQEKKQIKVAQALCEDLSALVKE-------EYLKAELSRQLEGILKSFKDVEQKA 2422
Query: 2303 KG---TLKDFTAQSTQVEKFINDITTWF-TKVEESLMN---CAQNETCEAL-KKVKDIQK 2354
+ L+ A S Q ++ D W TK EE + A+ + E+L K KD K
Sbjct: 2423 ENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSK 2482
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
L +Q T +L K +E +L + + + ++ + + L+ESL
Sbjct: 2483 TLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL 2542
Query: 2415 EK--HFSESMQEFQEWFLGAKAAAKE----SSDRTGDSKVLEAKLHDLQNILDSVSDGQS 2468
EK + E ++ W + +E G++ + AKL LQ +D G
Sbjct: 2543 EKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSI--AKLKSLQKEMDQ-HFGMV 2599
Query: 2469 KLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFE 2528
+L T + K++V+ + + ++ +Q K L++ + F+
Sbjct: 2600 ELLNNTANSLLSVCEIDKEVVTDENKSLI---QKVDMVTEQLHSKKFCLENMTQKFKEFQ 2656
Query: 2529 DQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRG 2588
+ ++ + +E+ + + S+ + + + + L L + +L+Q
Sbjct: 2657 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL 2716
Query: 2589 QLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVK 2648
+ + + G + H L + EK + LQ + ++ M+
Sbjct: 2717 VVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFA 2776
Query: 2649 AIQDRLAC-------AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQA--- 2698
D L AE+ K+T++ L +++ ++ M + E +
Sbjct: 2777 EFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL 2836
Query: 2699 ------LRSSNKEGQRV----------IQTQLETLKEVWADIMSSSVHAQSTLESVISQW 2742
L + +K+ ++ ++ ++ L+E ++ + S+ Q E SQ
Sbjct: 2837 VGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQG 2896
Query: 2743 NDYVERKNQLEQW-MESVDQKIE-HPLQPQ--------PGLKE---KFVLLDHLQSILSE 2789
+E + +Q M V QK E PLQ + GL + K L+ L +
Sbjct: 2897 PVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 2956
Query: 2790 AEDHTRALHRLIA-KSRELYEK-TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVE-EIV 2846
+ L++ +A ++ +L E F+D + L + VA +K E ++V
Sbjct: 2957 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVV 3016
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKE--LIDSR------- 2897
K + + D S E + R + ++ K+ +K+ L+DSR
Sbjct: 3017 KAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNK 3076
Query: 2898 -EIGASRLSRV--------ESLAPEVKQNTTAS----GCELMHTEMQALR---ADWKQWE 2941
E +L + E+L P + TT CE + T+ L A K E
Sbjct: 3077 AETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALE 3136
Query: 2942 DSVFQTQSCLENLVS--------------QMALSEQEFSGQVAQLEQALEQFSALLKTWA 2987
D + L VS M S+ +FS QV +E + S ++
Sbjct: 3137 DDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS-QVWYIEIQEKSHS---RSEL 3192
Query: 2988 QQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR---TEDLKSQLNELCRFSRDL---- 3040
Q L K E+ VE + E+ D L K + TE L Q +EL D+
Sbjct: 3193 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3252
Query: 3041 ----------------------STYSGKVSGLIKEYNCLCLQASKGCQNKEQILQ--QRF 3076
K+ + Y + ++ + EQ LQ +R
Sbjct: 3253 QNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRL 3312
Query: 3077 RKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGE 3136
+ WL ++ E S + + +E E++N + L+ +
Sbjct: 3313 HSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3372
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
L L+ +G++ V E ++ + QK ++ ++ + F+ +A+ W+
Sbjct: 3373 ALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWI 3432
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWE------- 3249
++TEK +L L R EQ + + L+ + ++ R K+ L +
Sbjct: 3433 TETEK-------KLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3485
Query: 3250 --GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAI 3307
+ +S + ++ ++ Y + + E+ +L+R + NQF +EL W+T+
Sbjct: 3486 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3545
Query: 3308 HMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQ 3367
++ P + L + + L + E + + + G +L+ + EG +IQ
Sbjct: 3546 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGF-SIQ 3604
Query: 3368 QQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHA 3427
++ + +++ + + L+ A+S+ T + D + Q L ER
Sbjct: 3605 EKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQI----------LESLERIVE 3654
Query: 3428 ELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERA 3487
LR ++ + + + E++ +E+ ++++ LQ Y +++R
Sbjct: 3655 RLRQPPSISAEVEKIKEQI-----------------SENKNVSVDMEKLQPLYETLKQRG 3697
Query: 3488 KEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHT----HETTLRDLQ 3543
+E + +S +D+ A V Q+KLDQ + + HT E L D+
Sbjct: 3698 EEMIARSGGT-------DKDISAKAV-----QDKLDQMVFIWENIHTLVEEREAKLLDVM 3745
Query: 3544 EL-QVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
EL + + +L+ ++ T++ + P + ++ ++ + + + + + +
Sbjct: 3746 ELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDI 3805
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGC 3662
V+N E+ A E ++ ++ +DE
Sbjct: 3806 VIN-----------------------LGSELIAACGEPDK--PIVKKSIDE--------- 3831
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
L S + +L ++I LEE +Q+ + + L + DW +++
Sbjct: 3832 ----LNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP---- 3883
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGER----AVKYLEEGEAERLRKEIHDH 3778
+G L+T++ ++++++ S + + ER A L++ E + + D
Sbjct: 3884 -----IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDP 3938
Query: 3779 MEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMEL 3834
+ +LK L + LE L +F L W+ + +L + +
Sbjct: 3939 LMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDP 3998
Query: 3835 YEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLEL---VQDVTLKDKIDQLQSDYQDL 3891
+ +L+K+ LQ VL+H+ +V++V + G L+E + L++K++ L +Q++
Sbjct: 3999 KAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNV 4058
Query: 3892 CSIGKAMMEEI-------AGFEDRLNNLQ------------------------------- 3913
+ +++ GF + +LQ
Sbjct: 4059 LEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHM 4118
Query: 3914 -----------------MKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
KG ++ +C + + Q+++ K+ + ++ +
Sbjct: 4119 EVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDIN----NLKEKWESVETKLNER 4174
Query: 3957 YQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQAR 4016
LE L + ++LQ WL+ + L + +P L + Q+ + +
Sbjct: 4175 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVN 4234
Query: 4017 TYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQ 4076
++ + + + D + +K ++ +Q I+ L+ Q+ WE++ E L
Sbjct: 4235 SHREQIIEL-DKTGTHLKYFSQ--KQDVVLIKNLLISVQS---RWEKVVQRLVERGRSLD 4288
Query: 4077 DADQQLQNMKRRHSEL-------------ELNIA------QNMVSQVKDFVKKLQSKQAS 4117
DA ++ + S+L EL IA + ++Q K+F K L +K +
Sbjct: 4289 DARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSV 4348
Query: 4118 VNTIIEKVNKLTKKEESPEHK-----EINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYH 4172
+T L +K + ++ L D+W +C +S + EE L + +
Sbjct: 4349 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4408
Query: 4173 DCMNVVEVFLEKFTTEW--DNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK 4230
D + + +L + + D D + ++ K L +R +++ LK ++
Sbjct: 4409 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4468
Query: 4231 MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAE 4290
+IE + DD VK Q L RW + L K L + S L+EW
Sbjct: 4469 LIEG-SRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLA 4527
Query: 4291 EQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNE-- 4348
E + + D + L+ H +LE K+ L D V+A +
Sbjct: 4528 EAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSIT 4587
Query: 4349 ---------RQVIQKALSDAQSH----VNCLSDLVGQRR---------KYLNKALSEKTQ 4386
R ++ L+ A+ H + L+ L+ ++ ++ L++K +
Sbjct: 4588 TIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDK 4647
Query: 4387 FLM--AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEV----- 4439
++ + + + I +H+ F E + DV K KT K A + Q+ +
Sbjct: 4648 EVIPQEIEEVKALIAEHQ---TFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDK 4704
Query: 4440 ----------TGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
+ L+ G + E + ++ K Q++ + +K + L LE+
Sbjct: 4705 GRAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEE- 4763
Query: 4490 LVSRKHFKEDFD----KACHWL--KQADIVTF 4515
R+ DFD K W+ K++ ++ F
Sbjct: 4764 --LREFANFDFDIWRKKYMRWMNHKKSRVMDF 4793
Score = 270 bits (691), Expect = 4e-71
Identities = 840/4709 (17%), Positives = 1807/4709 (38%), Gaps = 678/4709 (14%)
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEA--SEIPLGPQNKQLLQQQAKSIKEQV 1434
S L S+ S LE K + E E+ +KEA SEI + K ++ ++ Q
Sbjct: 303 SDLPSVESHLENHKNVHRAIEEF----ESSLKEAKISEIQMTAPLKLTYAEKLHRLESQY 358
Query: 1435 KKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIK 1494
KL +T + ++ + +F S +W+ EKE+E A + S + I++ K
Sbjct: 359 AKLLNTSRNQERHLDTLH----NFVSRATNELIWLNEKEEEEVAYDWSER--NTNIARKK 412
Query: 1495 ----VTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR--IKAKLTQIRRYGEELREHAQ 1548
++E++ K +I ++E A+ Q + AR I+A ++ + + Q
Sbjct: 413 DYHAELMRELDQKEENIKSVQEIAE---QLLLENHPARLTIEAYRAAMQTQWSWILQLCQ 469
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFED-KLAVPIKI-CSSATETYKV---LQEHM 1603
C+E H+ + + E +++ + K A+ K C ++ +K+ +QE M
Sbjct: 470 CVEQ----HIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESM 525
Query: 1604 DLCQALESLSSAITAFSASARKVV-----NRDSCVQEAAALQ-----QQYEDILRRAKER 1653
+ + L S I A+ ++ N D ++ + ++ +Q E + + E
Sbjct: 526 EEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDEC 585
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE- 1712
A + A W+ + + + + E A+R+ E + Q + L +E
Sbjct: 586 VLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRI--EQQYQNVLTLWHES 643
Query: 1713 ------VVSQASFYSKLLQLKESLFSVASKDDVKMM-----KLHLEQLDERWRDLPQIIN 1761
VVS +++ +++ S +VAS +K M + L L R+ D +
Sbjct: 644 HINMKSVVSWHYLINEIDRIRAS--NVAS---IKTMLPGEHQQVLSNLQSRFEDFLE--- 695
Query: 1762 KRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVE 1821
+ +S V +L +V K + EL ++E + V + + +EV
Sbjct: 696 ---DSQESQVFSGSDITQLEKEVNV-CKQYYQELLKSAEREEQEESV----YNLYISEVR 747
Query: 1822 SKKGELQSLQGHLAK-LGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEF 1880
+ + L++ + L + + + +DLH + + +L +E ++ + + EF
Sbjct: 748 NIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEF 807
Query: 1881 LQSHASLSGI------LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLD 1934
A+ S + L + Q + SM+ D + K +N L+N +A E A V L
Sbjct: 808 FSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKL-KTVNLVLKNTQAAE-ALVKL- 864
Query: 1935 GILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQ---SEADALAVLKKAFQ 1991
Y K+ E + + I+NL+ T + SE D + A +
Sbjct: 865 -------YETKLCEEEA----------VIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907
Query: 1992 DQKEELLKSIEDIEERTDKER------LKEPTRQALQQRLRVFNQLEDELNSHEHELCWL 2045
D+ ++ K+I D +T KER KE Q +++ V Q+++ L L
Sbjct: 908 DELQKA-KAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRD-------L 959
Query: 2046 KDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNL---- 2101
+ K + + P +D I ++E T +R I ENQ + + Q +
Sbjct: 960 EGIGKSLKYYRDTYHP-LDDWIQQVETT----QRKIQENQPENSKTLATQLNQQKMLVSE 1014
Query: 2102 -KSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL 2160
+ SK+ E T+KD E + ++ K K++ + S ++
Sbjct: 1015 IEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQ---SSADLII 1071
Query: 2161 SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWS 2220
E + + +LV T M + D ++LEE L + + E++ W
Sbjct: 1072 QEFMDLRTRYTALV-TLMTQYIKFAGDSLKRLEEEEKSLEEEKK---EHVEKAKELQKWV 1127
Query: 2221 NNCV------------PQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKV-ND 2267
+N P + IS+ + + E+L + ++ A +++ + N+
Sbjct: 1128 SNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNE 1187
Query: 2268 LKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWF 2327
L++ K L+ +L F E+ +++L+ ++ +V K K + + ++ + I
Sbjct: 1188 LEKQVKTLQESYNLLFSES--LKQLQESQTSGDV-KVEEKIVAERQQEYKEKLQGICDLL 1244
Query: 2328 TKVEESLMNCAQ----NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELE 2383
T+ E L+ + + LKK + Q+ELQ + + + E
Sbjct: 1245 TQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGE 1304
Query: 2384 SLGRAMTGLI--KKHEA---VSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAK- 2437
L + LI K +EA QL K + S +E L+K + +++E E K +
Sbjct: 1305 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKE-LDKVVTTAIKEETEKVAAVKQLEES 1363
Query: 2438 ---------------ESSDRTGDS--KVLEAKLHDLQ----------------NILDSVS 2464
+ S+R G +V+E Q N+L++
Sbjct: 1364 KTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDV 1423
Query: 2465 DGQ-----------------------SKLDAV---TQEGQTLYA----HLSKQIVSSIQE 2494
DGQ S+ AV TQ Q L +LS + +Q+
Sbjct: 1424 DGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK 1483
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
+ + ++ L + K + EL F+ + + W+ + E+ ENL
Sbjct: 1484 NMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQEL--ENLEAGA 1541
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL--LSEEGHGAGQEGRLCSQLLTSH 2612
I ++ + + F S D +S +G L ++ G+ + + CS+
Sbjct: 1542 DDINGLMTKLKRQKSF---------SEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1592
Query: 2613 QNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAEST----LGSKDTLE 2668
+ +E R A +L + +K + D+ E L E
Sbjct: 1593 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 1652
Query: 2669 KRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
S+ + ++ + K Q SS + ++ E L + ++ +
Sbjct: 1653 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAK 1712
Query: 2729 VHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
Q TL+ ++ ++ D + N+ E + + L Q GL E + +++S L
Sbjct: 1713 NDIQKTLDDIVGRYEDLSKSVNERN---EKLQITLTRSLSVQDGLDEMLDWMGNVESSLK 1769
Query: 2789 EAED---HTRALHRLIAKSREL--------------------YEKTEDESFKDTAQEELK 2825
E ++ AL +I+K+ L + +T D S + Q ++K
Sbjct: 1770 EQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMK 1829
Query: 2826 ---TQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGD-SS 2881
+F++ KE + K+EE+ ++ + + +L + + L D +
Sbjct: 1830 DLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE 1889
Query: 2882 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2941
+Q E ++ ++ L + SL E+ + S L+ + L +K+ E
Sbjct: 1890 LSQYMQESTSEFLEHKK----HLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEME 1945
Query: 2942 DSVFQTQ----SCLENL-----------------VSQMALSEQEFSGQVAQLEQALEQFS 2980
D++ + + SC E L ++ + + F + L ++LE
Sbjct: 1946 DTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE--DLGKSLEDTK 2003
Query: 2981 ALLKTWAQQL--------------TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
L + W+ + L+ T + + G +L+ + TE+
Sbjct: 2004 KLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG-EGTATNTEEF 2062
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+ L +D++ S L L L+ N + Q+ ++ QW
Sbjct: 2063 WANKG-LTSIKKDMTDISHGYEDL-----GLLLKDKIAELNTKLSKLQKAQEESSAMMQW 2116
Query: 3087 L--VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK-GELLSTLLT 3143
L +N T + P + V T +++ + F +E + +K+ + K ELL
Sbjct: 2117 LQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPD 2176
Query: 3144 KEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMV 3203
+A + +T W+ + ++ LE + F+ ++ WL + E MV
Sbjct: 2177 TPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMV 2236
Query: 3204 HESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFR----H 3259
D ++Q++Q +L+E +PQ +L Q + S R
Sbjct: 2237 SVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKE 2296
Query: 3260 RVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSD 3319
+++ ++ ++ +L+ ++ +D+ + + Q+ ++ L D ++D + L S ++
Sbjct: 2297 QLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTH 2356
Query: 3320 KSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWA 3378
++ + + + Q+++ Q+K+ E + E + + +QL+ + +
Sbjct: 2357 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFK 2416
Query: 3379 SLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGK 3438
+ L+ A + +Q R F W+D+ + N+S A+L +++
Sbjct: 2417 DVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKD 2476
Query: 3439 AKLLNEEVLSYSSLLETIEVKGAGM------TEHYVTQLELQDLQERYRAIQERAKEAVT 3492
K ++ + + S + E +G + +E QL+L ++ + ++ KE
Sbjct: 2477 HKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKEREN 2536
Query: 3493 KSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQ--YSVLEGDAHTHETTLRDLQ-ELQVHC 3549
K ++ + +Y+ ++ W+ + Q L++ + + + L+ LQ E+ H
Sbjct: 2537 KLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHF 2596
Query: 3550 AEGQALLN------SVLHTREDVIPS---GIPQAEDRA----------LESLRQDWQAYQ 3590
+ L N SV ++V+ + Q D LE++ Q ++ +Q
Sbjct: 2597 GMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQ 2656
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQV--DEWLKTAEEKKWHEEVTAYRDEVEEVGARAQ 3648
E++ Q +L + + Q +++L + ++ + + A + +V+ AQ
Sbjct: 2657 EVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQ--KSLQALKHQVDLAKRLAQ 2714
Query: 3649 EILDE---SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDW 3705
+++ E S S + Q + + L QV E+ FLE ++Q + ++++
Sbjct: 2715 DLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQ 2774
Query: 3706 YGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEE 3765
+ ++A +T+ K+ +T++ LK +E L ++ + + K +
Sbjct: 2775 FAEFDDELDSMAPVGRDAETLQ--KQKETIKAFLKKLEA----LMASNDNANKTCKMMLA 2828
Query: 3766 GEAER-----LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEY 3820
E +++++ +Q +L + +E + +EF K K + + +
Sbjct: 2829 TEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKA 2888
Query: 3821 QEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK 3880
+E ME QL+ +K Q K++
Sbjct: 2889 EEHEESQGPVGMETETINQQLNMFKVFQ-----------------------------KEE 2919
Query: 3881 IDQLQSDYQDLCSIGKAMMEEIA------GFEDRLNNLQMKGDTLIGQCADHLQAKLKQN 3934
I+ LQ QD+ +G+ +++ A G E L+++ + TL +
Sbjct: 2920 IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKK------------ 2967
Query: 3935 VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSR-QDTLQQCQAWLSAVQPDLEPSPQ 3993
AQR Q E L H R QD L+ +W+ + +L + +
Sbjct: 2968 -----------------VAQRAAQLQEALL--HCGRFQDALESLLSWMVDTE-ELVANQK 3007
Query: 3994 PPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK--- 4050
PP + + +K +QEQ LL + D ++V+ ++ ++ T E
Sbjct: 3008 PPSAEFKVVKA-----QIQEQK-----LLQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057
Query: 4051 --LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNM----KRRHSELELNIAQNMVSQV 4104
L Q L WE + + K+E ++QL+ + ++ H LE +
Sbjct: 3058 KILKQLSLLDSRWEALLN-KAET------RNRQLEGISVVAQQFHETLE---------PL 3101
Query: 4105 KDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREED 4164
+++ ++ + + I + +KL +E+ +HK + ++
Sbjct: 3102 NEWLTTIEKRLVNCEPIGTQASKL--EEQIAQHKALE--------------------DDI 3139
Query: 4165 LQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ + H +++ + + E ++ +S + + V + +QE+ ++ +L
Sbjct: 3140 INHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY-------IEIQEKSHSRSEL 3192
Query: 4225 KDQKQKMIEHLNLDDKEL------VKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVV 4278
Q + D+ EL V ++ S L + + E L K++ ++ V + L
Sbjct: 3193 LQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRK 3252
Query: 4279 QSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDAD 4338
Q+ Q L+ N E LKQ+ ++ L I +LEA +K+ KD
Sbjct: 3253 QNVDQALL--------NGLELLKQTTGDEV--------LIIQDKLEA----IKARYKDIT 3292
Query: 4339 RVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQI 4398
++ D+ Q +Q A +H +L K + LS +TQ L + SQ
Sbjct: 3293 KLSTDVAKTLEQALQLARRLHSTH----EELCTWLDKVEVELLSYETQVLKG--EEASQA 3346
Query: 4399 QQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGL--WAQGRELMKEVTEQ 4456
Q P ++ K+ K K+ SL + + L W L K V E
Sbjct: 3347 QMR-------------PKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAED 3393
Query: 4457 EKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD--IVT 4514
+ + V D++ QK ++E++ ++ + F + D W+ + + +++
Sbjct: 3394 N--------ERYRLVSDTITQK----VEEIDAAILRSQQFDQAADAELSWITETEKKLMS 3441
Query: 4515 FPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKL 4574
+I L E + QL + + +++++ L ++G I+ + +E + + +KL
Sbjct: 3442 LGDIRL--EQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKL 3499
Query: 4575 NALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLA 4634
+ + + ++ I + +++ +++ A ++ E L+E ++ +S++P
Sbjct: 3500 DKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSI---ISQLPAPAL 3556
Query: 4635 VEEAL-SLQDGCRAILDEVAGLGEAVDELNQKKEGFR--STGQPWQ-PDKMLHLVTLYHR 4690
E L Q+ R + + +A +D++N+ S G+ + +K + TLY +
Sbjct: 3557 EYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQ 3616
Query: 4691 LKRQTEQRVSLLEDTTS-AYQEHEKMCQ---QLERQLKSVKEEQSKVNEETLPAEEKLKM 4746
+K ++R L++ S + Q H+K+ Q LER ++ +++ S ++ E +E++
Sbjct: 3617 IKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPS-ISAEVEKIKEQISE 3675
Query: 4747 YHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVT 4806
+++ ++ + + + E++ + + +Q ++ + I V
Sbjct: 3676 NKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVE 3735
Query: 4807 ECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQI-------- 4858
E E++++ ++ + W + L + ++D Q+ IR ++
Sbjct: 3736 EREAKLLDVMELAEKF-----WCDHMS--------LIVTIKDTQDFIRDLEDPGIDPSVV 3782
Query: 4859 --HQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-------LEHSLAELSELDGDIQEA 4909
QE ++ ++ L + ELI+A ++ S+ EL+ + +A
Sbjct: 3783 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 3842
Query: 4910 LRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQ-ELLQLAGNGLDVESAEENLKSHMEFF 4968
+ R L E +Y QA DW++ A +L ++ G D+E+ ++ ++ +F
Sbjct: 3843 WKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK 3902
Query: 4969 STEDQFHSNLEEL-HSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQR 5027
S Q +E L H L + + + K ++ + L+L + + L+
Sbjct: 3903 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 3962
Query: 5028 CTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEK 5087
+Q A +E++ + TE LSE + E +L++H L + V +
Sbjct: 3963 ALLALGQFQHALDELLAWLTHTEGLLSEQKPVG-GDPKAIEIELAKHHVLQNDVLAHQST 4021
Query: 5088 IVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNN 5147
+ A+ + + L ++ + L + + QRW + + +++ L+ A+ + GF+
Sbjct: 4022 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4081
Query: 5148 KVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSM 5207
+++ + + + L S L H E ++ L Q+ M
Sbjct: 4082 EIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQM 4141
Query: 5208 LQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCW 5267
L A E + Q+I ++++ +++ K+ +++ L + W
Sbjct: 4142 L---ARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4198
Query: 5268 VQETKEYLG---NPTIEIDA---QLEELQILLTEATNHRQNIEKMAE--------EQKEK 5313
+ + ++ L P++ +D Q++E ++ E +HR+ I ++ + QK+
Sbjct: 4199 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4258
Query: 5314 YLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
+ + +L S S V ++ + D K +Q +L +++ K L +
Sbjct: 4259 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4318
Query: 5374 LTKL----KAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKK 5429
L K KT + Q K QK LG + + + + L++ L K
Sbjct: 4319 LEIANDPDKIKTQ-LAQHKEFQKSLGAK-----HSVYDTTNRTGRSLKEKTSLADDNLKL 4372
Query: 5430 IGKLTELHQQ---TIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWN 5486
L+EL + ++ R +KL +A ++ + L+ ++ W+ + +
Sbjct: 4373 DDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE---------- 4422
Query: 5487 SASQLREQYILH------QTLLEESKEIDSELEAMTEKLQYLT---------SVYCTEKM 5531
QL E +H L++ K EL T +Q L S + +
Sbjct: 4423 --PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV 4480
Query: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEV-- 5589
Q+ EL E + + + L+ A + ++F + + L L +A+ TL V
Sbjct: 4481 KVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLP 4540
Query: 5590 -GRLSLKEQLSHRQHLLSEMESLKPKV-QAVQLCQSALRI--PEDVVASLPLCHAALRLQ 5645
+L+ + + + ++E + ++ +A + + L I P+ + + H ++
Sbjct: 4541 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITT---IKHWITIIR 4597
Query: 5646 EEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREI--EDKPVATSNIQEL 5703
+ A Q + +A+ ++ ++ L ++ A + +DK V I+E+
Sbjct: 4598 ARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEV 4657
Query: 5704 QAQISRHEELAQKIKGYQEQIASLNSKCK 5732
+A I+ H+ +++ Q + + K
Sbjct: 4658 KALIAEHQTFMEEMTRKQPDVDKVTKTYK 4686
Score = 270 bits (691), Expect = 4e-71
Identities = 774/4191 (18%), Positives = 1624/4191 (38%), Gaps = 555/4191 (13%)
Query: 4702 LEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVL 4761
L S + H+ + + +E S+KE +K++E + A KL Y L+ L
Sbjct: 305 LPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLT-YAEKLHRLESQYAKL 361
Query: 4762 KRVTIHLEDLAPHLDPLA--YEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQ 4819
+ + E HLD L +A +++ W E + + +E + + + D+
Sbjct: 362 LNTSRNQER---HLDTLHNFVSRATNEL-IWLNEKE--EEEVAYDWSERNTNIARKKDYH 415
Query: 4820 TEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE 4879
E+ R LD N++ +QE ++ + + ++ A +
Sbjct: 416 AELMRELDQKEE-------------NIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWS 462
Query: 4880 KFTKAKELISADLEHSLAELSELDGDIQEA---LRTRQATLTEIYSQCQR---YYQVFQA 4933
+ + + ++ + A E D +EA LR + + YS C R +++
Sbjct: 463 WILQLCQCVEQHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYS-CDRSSSIHKLEDL 520
Query: 4934 ANDWLEDAQELLQ-------LAGNG-----LDVESAEENLKSHMEFFSTED--QFHSNLE 4979
+ +E+ +ELLQ L G L +++ LK+ + + D Q +
Sbjct: 521 VQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIY 580
Query: 4980 ELHSLVATLDP------LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDL-LQRCTAQW 5032
+ V + +I PTG E + V + + D +++ Q W
Sbjct: 581 KDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW 640
Query: 5033 HDYQKAREEVIE---LMNDTEK-KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKI 5088
H+ + V+ L+N+ ++ + S + +KT EH+ ++S + S E
Sbjct: 641 HESHINMKSVVSWHYLINEIDRIRASNVASIKTMLP-------GEHQQVLSNLQSRFEDF 693
Query: 5089 VALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
LE+ +G+D ++ L + + Q + L A+ +E+ E++V + + ++
Sbjct: 694 --LEDSQESQVFSGSDITQ--LEKEVNVCKQYYQELLKSAEREEQ--EESV--YNLYISE 745
Query: 5149 VKKATEMIDQLQDKLPG---SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTL 5205
V+ ++ +D+L + E+ E + + + ELE+ + LG + +
Sbjct: 746 VRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCE 805
Query: 5206 SMLQDGAAPTPGEEPPLMQEITAM---QDRCLNMQEKVKTNGKLVKQELKDREMVETQIN 5262
AA + P L E+ + ++ +M K V LK+ + E +
Sbjct: 806 EFFSQAAASS--SVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVK 863
Query: 5263 SVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTIL 5321
+ + E + + + I+ + L+ +E RQ + +E QK K +
Sbjct: 864 LYETKLCEEEAVIADKN-NIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAIS----- 917
Query: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
E+ E LD + D++ E Q + QI +DL I LK
Sbjct: 918 -DEMFKTYKERDLDFDWHKEKADQLVE------RWQNVHVQIDNRLRDLEGIGKSLKYYR 970
Query: 5382 DN-------VVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLT 5434
D + Q +T Q+ + E NSK + QK L ++ + + K
Sbjct: 971 DTYHPLDDWIQQVETTQRKIQENQPE-NSKTLATQLNQQKMLVSEIEMKQSKMDECQKYA 1029
Query: 5435 ELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW-IEKAKVLAHGTIAWNSASQLRE 5493
E + T++ E + Y M++ K +++ ++ + + LR
Sbjct: 1030 EQYSATVKDYELQTMT----------YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT 1079
Query: 5494 QYILHQTLL---------------EESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAEL 5538
+Y TL+ EE K ++ E + EK + L + + AE
Sbjct: 1080 RYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEK 1139
Query: 5539 GRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQL 5598
+ +Q I + ++ + ++ L+ +Q L + +T E L + +
Sbjct: 1140 AGKPPFSKQKI-----SSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKT 1194
Query: 5599 SHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP---------LCHAALRLQEEAS 5649
+ L ESLK ++Q Q +++ E +VA +C L Q E
Sbjct: 1195 LQESYNLLFSESLK-QLQESQT-SGDVKVEEKIVAERQQEYKEKLQGICD--LLTQTENR 1250
Query: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISR 5709
+ H Q+ ++ V+ ++Y+ + + LQ+ ++G+ + + + T N +
Sbjct: 1251 LIGH---QEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLK-----EN 1302
Query: 5710 HEELAQKIKGYQEQ-IASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
E+L+Q+ K EQ + KC+ L +KA+ + L + E TE +
Sbjct: 1303 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEE 1362
Query: 5769 SAHP--------SVVMMTAGRCHTLLSPVTEESG---EEGTN-SEISSPPACRS------ 5810
S S V + R T V E++G +EG S I
Sbjct: 1363 SKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1422
Query: 5811 -PSPVANTDASVNQDIAYYQALSA--ERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLG 5867
V T ++NQ YQ + A E++ + + +T ++Q E + + +
Sbjct: 1423 VDGQVGTTQENLNQQ---YQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKE 1479
Query: 5868 DLQRSWETLKNVISEKQRTLYE-ALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE 5926
LQ++ + LK YE AL +K S+ ++E + +E + E
Sbjct: 1480 KLQKNMKELK--------VHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSE 1531
Query: 5927 SQMAEHQALMDEILMLQDEINELQSSLAEELVS-------------------ESCEADPA 5967
++ +A D+I L ++ Q S +E+++S +SC
Sbjct: 1532 QELENLEAGADDINGLMTKLKR-QKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDG 1590
Query: 5968 EQLALQSTLTVLAERM--STIRMKAS-GKRQLLEEKLNDQLEEQRQEQALQRYRCEADEL 6024
++ +T + ++ +T R ++ K +L L D +++ Q Y + L
Sbjct: 1591 GKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKY------QHYEDASCGL 1644
Query: 6025 DSWLLSTKATLDTALSPP--KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
+ L + +AT LS P +P +++ QL + + + +I + VA+ +L E +LL+
Sbjct: 1645 LAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAE-VLLD 1703
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQ 6142
+ + L + G +L ++++++ +Q +T T+S VQ
Sbjct: 1704 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQ------------ITLTRSLSVQ 1751
Query: 6143 EWLAQARTTWTQQRQSSLQQQKE-------LEQELAEQKSLLRSVASRGEEILIQHSAAE 6195
+ L + W +SSL++Q + L+ +++ L + +A R I + +
Sbjct: 1752 DGLDEM-LDWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVK 1810
Query: 6196 TSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH--QEFSTKQKLLQNVLEQEQEQV 6253
+ + S + M+ + + E+L +E TK +L +N+ E+ Q
Sbjct: 1811 KFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENL--SEKLQT 1868
Query: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLY 6313
+ L+ V DVP +D + L+Q +E +S+ K+ L L
Sbjct: 1869 FLETKTQALTEV-----DVPGKDVTE-------LSQYMQESTSEFLEHKKHLEVLHSLLK 1916
Query: 6314 DGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAF 6373
+ +++ LP + L L+K KEM + + + K +
Sbjct: 1917 E-----------------ISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC- 1958
Query: 6374 PENGDNRDVIEDTLGCLLGRLSLLDSVVNQR--CHQMKERLQQILNFQN--DLKVLFTSL 6429
E D V+ +L + + +V + + L+ Q LK
Sbjct: 1959 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2018
Query: 6430 ADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQ------ 6483
+N I L L + P A+ I A++ +G L G E+
Sbjct: 2019 VNNSGISLCNLISAVTTP-AKAIAAVK----------SGGAVLNGEGTATNTEEFWANKG 2067
Query: 6484 --PSMQELSKLQDMYDELMMIIGSRRSGLNQNLT-LKSQYERALQDLADLLETGQEKMAG 6540
++++ + Y++L +++ + + LN L+ L+ E + + L + +
Sbjct: 2068 LTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKW 2127
Query: 6541 DQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKET--------QFH 6592
Q + E ++ ++++K + L+ ++ + L K+ + Q
Sbjct: 2128 QQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQML 2187
Query: 6593 TELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENED 6652
TE+ ++ + + R +LE + + +L + L E + +G + + +
Sbjct: 2188 TEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPN 2247
Query: 6653 RLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD------LESQLNQLGECWL 6706
L + Q L +P+ Q+ G+ +L S D ++ QL + + W
Sbjct: 2248 MLNTQRQQVQILLQEFATRKPQYEQLTAAGQGIL-SRPGEDPSLRGIVKEQLAAVTQKWD 2306
Query: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
S T ++S ++ + T+YQS L L ++L S+ V + +
Sbjct: 2307 SLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLS----SSLAVSTHPDAMNQ 2362
Query: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPA 6826
L + +E+ + + L L K + L++ELSR Q +L +
Sbjct: 2363 QLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSR---QLEGILKSFKD 2417
Query: 6827 VQEKLH---QLQMDKLPSRHAISEV----MSWISLMENVIQKDEDNIKNSIGYK--AIHE 6877
V++K Q S H ++ +W+ +K+E N + I K +
Sbjct: 2418 VEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDT-----KKEEQNKSHPISAKLDVLES 2472
Query: 6878 YLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQG 6937
++ +K F + + +++ + + ++++ S+K QL + +W
Sbjct: 2473 LIKDHKDFSKTLTAQS---HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNK 2529
Query: 6938 LVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLE 6997
V E+ L+ LE +Y+ V+ L W + + L++ D A +N++ + L+
Sbjct: 2530 QVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQ 2589
Query: 6998 ------------------DLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST---LREL 7036
L+ E + E + +LIQ K + V+ + S L +
Sbjct: 2590 KEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ-KVDMVTEQLHSKKFCLENM 2648
Query: 7037 GQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQ 7096
Q + + + K L+ +Q H D + S +Y L+ + SL+A++
Sbjct: 2649 TQKFKEFQEVSKESKRQLQCAKEQLDIH----DSLGSQAYSNKY-LTMLQTQQKSLQALK 2703
Query: 7097 VQVDNLQNLQDDLEKQ--------------ERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
QVD + L DL + E Q+ +++ Q+ ++C L L
Sbjct: 2704 HQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC-----SFLETKL 2758
Query: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
+ + N + E ++ + L + +D A T+Q+Q++ LK
Sbjct: 2759 QGIGHFQNTIREMFSQFAEFDDELDSMAPVGRD-----AETLQKQKETIKAFLKKLEALM 2813
Query: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
++D + C +L T D + I+ D +LS+
Sbjct: 2814 ASNDNAN---KTCKMMLATEETSPDLV--------------------GIKRDLEALSKQC 2850
Query: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERM 7322
L ++ ++ + E F L+ + +AEE + Q P + TI +++
Sbjct: 2851 NKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPV-GMETETINQQL 2909
Query: 7323 EELKG-QMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNL-------NRHWSLISSQTT 7374
K Q + + +N LG L + + Q L N W ++ +
Sbjct: 2910 NMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVA 2969
Query: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SGNYQHLLEQQRAHELFQAE 7432
+R ++LQ LL F + E+ + ++V TE+ +A + S ++ + Q + +L Q
Sbjct: 2970 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3029
Query: 7433 MFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIR 7492
+ R+ + I +G+++ + D+ + +L+LL ++W+ ++ +A+ R ++
Sbjct: 3030 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISV 3089
Query: 7493 QWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFK--EKVFLRQQGSY 7550
Q++ E E L +WL + ++ PI Q ++ Q K E +
Sbjct: 3090 VAQQFHETLEPLNEWLTTIEKRLVN---CEPIGTQASKLEEQIAQHKALEDDIINHNKHL 3146
Query: 7551 ILTVEAGKQLLLSADSGAEAALQAEL-------AEIQEKWKSASMRLEEQKKKLAFLLKD 7603
V G+ L + + + +Q++L EIQEK S S L++ +D
Sbjct: 3147 HQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3206
Query: 7604 WEKCEKGIADSLEKLRTFKKK--LSQSLPDHHEELHAEQ----MRCKELENAVGSWTDDL 7657
+ + + +KL + ++ L EL Q +R + ++ A+ L
Sbjct: 3207 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQAL------L 3260
Query: 7658 TQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEK 7717
L LLK T + D++ I+ +++E ++ +++++ + + + + L
Sbjct: 3261 NGLELLKQT-----TGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHST 3315
Query: 7718 NKELCEWLTQMESKV-SQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKAS 7776
++ELC WL ++E ++ S +L E + + +E A+ NK L + E ++ A
Sbjct: 3316 HEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNE-VSSAL 3374
Query: 7777 HES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAH 7832
E +A E +E + + N+R++ + D I +V+++ ++ QQ D+ + +W+
Sbjct: 3375 LELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITE 3434
Query: 7833 IESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7892
E +L + ++ +L Q+ +I +H + ++ ++ C ++
Sbjct: 3435 TEKKLMS-LGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTAC----SE 3489
Query: 7893 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 7952
E S+++ + + + IC ++ ER L++E L +F + Y WL ++ +
Sbjct: 3490 EEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIIS 3549
Query: 7953 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVH 8012
+ + Y +++ ++ + + E ++ +NK +L E S+++
Sbjct: 3550 QLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLL-ELSPGEGFSIQEKYV 3608
Query: 8013 EGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQ 8072
+ + +++ V L I Q +F D IL L + +L S +V+
Sbjct: 3609 AADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSIS-AEVE 3667
Query: 8073 AKIKQLKAFQQEISLNHNKI----EQIIAQGEQLIEKS----EPLDAAIIEEELDELRRY 8124
KIK+ + + +S++ K+ E + +GE++I +S + + A ++++LD++
Sbjct: 3668 -KIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFI 3726
Query: 8125 CQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSS 8184
+ + VE +RE +L D L++ W D + +++ + +
Sbjct: 3727 WENIHTLVE-------------------EREAKLLDVMELAEKFWCDHMS-LIVTIKDTQ 3766
Query: 8185 NLSLSLAQP------LRSERSGRDT-PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
+ L P ++ ++ +T +D + E D +L +L +A
Sbjct: 3767 DFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAAC--------- 3817
Query: 8238 EGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDS 8297
G+ DK + I E A+ L + A+++ + Q L
Sbjct: 3818 -GEPDKPIVKKS--------IDELNSAWDSLNKAWKDRIDKLEEAMQAAV-QYQDGLQAV 3867
Query: 8298 RFQIQQTENIIRSKTPTGPELDTSYKGYMKLL---GECSSSIDSVKRLEHKLKEEEESLP 8354
+ + S +P G +L+T + +L E ++RL H+ + + +
Sbjct: 3868 FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVT 3927
Query: 8355 GFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE 8414
+ H+ + + W+ L+ + ++++ +++ L QF L+ + AWL TE
Sbjct: 3928 EESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL 3987
Query: 8415 LEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADS-KESRDLQ 8473
L + + + D + IE+++ K LQ V ++ + ++N + ++ + +E+ +LQ
Sbjct: 3988 LSEQK--PVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQ 4045
Query: 8474 DRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDS 8533
++L +N RW V E+ + L AL Q +GFH L L + +R P+
Sbjct: 4046 NKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGG 4105
Query: 8534 ---------NLDAEIL------QDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGT 8578
N+ E+ ++ +K LMQ ++L + S + ++ +
Sbjct: 4106 LPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQML-------ARCPKSAETNIDQDIN 4158
Query: 8579 DCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADE 8629
+ E E V N K L+E L ++ +S QD +W + E
Sbjct: 4159 NLKEKWESVETKLNERKTKLEEA------LNLAMEFHNSLQDFINWLTQAE 4203
Score = 270 bits (691), Expect = 4e-71
Identities = 734/4041 (18%), Positives = 1546/4041 (38%), Gaps = 628/4041 (15%)
Query: 449 IQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508
++++LE+ KD L F + + + +P +L + + + V S S ++
Sbjct: 786 LKKELERLKDDLGTITNKCEEFFS--QAAASSSVPTLRSELNVVLQNMNQVYSMSSTYID 843
Query: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
K++ + L +L AE+ +K + K E+V N + I K +
Sbjct: 844 KLKTVNL---VLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSE----- 895
Query: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
+ + +++ + +++A+ + M +T + R+L + ++ ++++ W N
Sbjct: 896 -VDEKRQVFHALEDELQKAKAISDEMFKTYKE-RDLDFDWHKEKA--DQLVERWQ---NV 948
Query: 629 VASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQ 688
+ L D E + +S +D + L WIQQ + ++ L Q
Sbjct: 949 HVQIDNRLRDLEG-IGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQ 1007
Query: 689 QLLLLNGRWRELFMEVKQYAQADEMDRMKKEYT----DCVVTLSAFATEAHKKLSEPLEV 744
Q +L++ +E+KQ ++ DE + ++Y+ D + + + P++
Sbjct: 1008 QKMLVSE------IEMKQ-SKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKR 1060
Query: 745 SFM--NVKLLIQDLEDIEQR----VPVMDAQYKIITKTAHLITKE--SPQEEGKEMFATM 796
M + L+IQ+ D+ R V +M K + + +E S +EE KE
Sbjct: 1061 RRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKA 1120
Query: 797 SKLKEQLTKV-----------KECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEII 845
+L++ ++ + K +S S+++ E+L + + + L K + +
Sbjct: 1121 KELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKM 1180
Query: 846 TVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ---- 901
T ER + + L E+ K+ G V++ + ++ ++
Sbjct: 1181 TDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGI 1240
Query: 902 ----TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
T+ + ++ AF + T + KK+ L K + S L +V++ + L
Sbjct: 1241 CDLLTQTENRLIGHQEAFM-IGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL 1299
Query: 958 EEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKD 1017
+E G+ + E + ++Q++ A +K C++L ++ EQ ++ L + V
Sbjct: 1300 KENGE-----KLSQEDKALIEQKLNEAKIK-CEQL-NLKAEQSKKELDKVVTTA------ 1346
Query: 1018 LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP--QEGSEKIIKEHRVFFSDK 1075
+K + EK + +EE +T+++ + + SE+ +H+
Sbjct: 1347 -----------IKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQN 1395
Query: 1076 GPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD 1135
G H I E D V ++ ++ + +T L + K K
Sbjct: 1396 GTHFQEGDGKSAIGE-------EDEVNG-----NLLETDVDGQVGTTQENLNQQYQKVK- 1442
Query: 1136 YTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRL 1195
++ IS ++ + + + G+ E+ E L L
Sbjct: 1443 -----AQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEK---------EKLQKNMKEL 1488
Query: 1196 KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEEL 1255
KV E + LA+ K +L E+EK +++ + + + + LE L
Sbjct: 1489 KVHYETA-----------LAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENL 1537
Query: 1256 ISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD 1315
+G+ ++ K+ ++ E ++ H+ + I+ V + + +GG D
Sbjct: 1538 EAGADDINGLMTKLKRQKSFSED---VISHKGDLRYITISGNRVLEAAKSCSKRDGGKVD 1594
Query: 1316 RG--HEEL-RKLESTLDGLERSRERQE---RRIQVTLRKWERFETNKETVVRYLFQTGSS 1369
H E+ RKL+ D + ++ + K++ +E ++ L ++
Sbjct: 1595 TSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1654
Query: 1370 HERFLS---FSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQL---- 1422
+ LS ++L +LE+TK + S V E L K+ +E+ L + L
Sbjct: 1655 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKL-KKTAEVLLDARGSLLPAKN 1713
Query: 1423 ------------LQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470
+ +KS+ E+ +KL+ TL + + + D G+ +
Sbjct: 1714 DIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN--------VE 1765
Query: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530
KE + +S+A+ IS+ + Q+I + SSI + E+ + F + ++ ++
Sbjct: 1766 SSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQ 1825
Query: 1531 AKLTQI-RRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI- 1588
AK+ + R+ E +H + L + L + + ENL + Q+ E + + + +
Sbjct: 1826 AKMKDLSARFSEASHKHKETL--AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP 1883
Query: 1589 CSSATETYKVLQ-------EHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQ 1641
TE + +Q EH + L SL I++ + K + + + +
Sbjct: 1884 GKDVTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK-TNNLSKKFK 1942
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISA------- 1694
+ ED ++ KE T+ + L +Q L K L S W++ K + A
Sbjct: 1943 EMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKS---WIKETTKKVPIVQPSFGAEDLGKSL 1999
Query: 1695 -DRVKVEGELQL----IQALQNEVVSQASFYSKLLQLKESLFSVAS-------------- 1735
D K++ + L IQ + N +S + S + +++ +V S
Sbjct: 2000 EDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNT 2059
Query: 1736 -----KDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI-- 1788
+ +K + + + DL ++ +I L + +++ Q+ E + W+
Sbjct: 2060 EEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQK 2119
Query: 1789 --KLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAED- 1845
K QT + + + ++K AE++ ++Q L+ L +L L D
Sbjct: 2120 MNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTEL--LEENPDT 2177
Query: 1846 ---------LHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGIL--RQL 1894
L + K ++ QL + Q +E + ++L +F A L L ++L
Sbjct: 2178 PEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEE---SSNNLTQFQTVEAQLKQWLVEKEL 2234
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQ----NAKALESAAVSLDGILSKAQYHLKIGSSE 1950
+V S++ N + + + LQ E + GILS+ E
Sbjct: 2235 MVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR--------PGE 2286
Query: 1951 QRTSCRATADQLCGEVERIQNLLGTKQSEADAL--AVLKKA-FQDQKEELLKSIEDIEER 2007
+ +QL ++ +L G D + A++K +Q L + D++ +
Sbjct: 2287 DPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNK 2346
Query: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQ--KDVAFAPEVDR 2065
A+ Q+L +++ E+ + ++ + + ++ K+ E+ R
Sbjct: 2347 LSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2406
Query: 2066 EINRLEVTWDDTKRL----IHENQGQCC-------------GLIDLMREYQNLKSAVSKV 2108
++ + ++ D ++ + Q C +D +E QN +S
Sbjct: 2407 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAK 2466
Query: 2109 LENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS 2168
L+ V + IKD +D FSK TA++ M K ++G++L L K
Sbjct: 2467 LD------VLESLIKDHKD----FSKTLTAQSHMYEKT------IAEGENL---LLKTQG 2507
Query: 2169 SDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSL-----------SIW----------D 2207
S+ + ++ + + W +++++E ++L+ SL ++W +
Sbjct: 2508 SEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE 2567
Query: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLK----------EFESEV---KNK 2254
++ D EG N + ++ +D H ELL E + EV +NK
Sbjct: 2568 EIKFCLDPAEG--ENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENK 2625
Query: 2255 AL------RLEELHSKVNDLKELTKNL--------ETPPDLQFIEADL------------ 2288
+L E+LHSK L+ +T+ E+ LQ + L
Sbjct: 2626 SLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYS 2685
Query: 2289 ----------MQKLEHAKEITEVAKGTLKDFTAQST----------QVEKFINDITTWFT 2328
+ L+ K ++AK +D +++ QVE + +T
Sbjct: 2686 NKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQ 2745
Query: 2329 KVEESL---------MNCAQNETCEALKKVKDIQKE-------------LQSQQSNIS-- 2364
+V+E + QN E + + E LQ Q+ I
Sbjct: 2746 QVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF 2805
Query: 2365 --------STQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEK 2416
++ +N N C+ + E S + G+ + EA+S+ C+K Q + E+
Sbjct: 2806 LKKLEALMASNDNANKTCKMMLATEETS--PDLVGIKRDLEALSKQCNKLLDRAQ-AREE 2862
Query: 2417 HFSESMQEFQEWFLGAK------AAAKESSDRTGDSKVLEAKLHDLQNIL-----DSVSD 2465
+++ +E++ K A+E + G + ++ N+ + +
Sbjct: 2863 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 2922
Query: 2466 GQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQALQDCASEL 2524
Q K V GQ L +K ++ + N ++ K+ + LQ+
Sbjct: 2923 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 2982
Query: 2525 GSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARES-LDK 2583
G F+D L W+ + EE + ++ + + + + K+ L LL R+S ++
Sbjct: 2983 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKL---LQRLLDDRKSTVEV 3039
Query: 2584 LSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQ------VALQEHEALE 2637
+ + G+ ++ A + L L + + K + R+ Q VA Q HE LE
Sbjct: 3040 IKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3099
Query: 2638 EALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ---IQDILLMKGEGEVKLNMAIGK 2694
+ W+ I+ RL E LE++++Q ++D ++ + L+ A+
Sbjct: 3100 PLNE----WLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNK---HLHQAVSI 3152
Query: 2695 GEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2754
G+ S++E + ++Q++L+ + + +I S L+ + + E + +L
Sbjct: 3153 GQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3212
Query: 2755 WMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK---T 2811
W+ V K+ K + D+ L + + R L I ++ ++
Sbjct: 3213 WLNEVHDKL-----------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLN 3261
Query: 2812 EDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELH 2871
E K T +E+ D + K + + + ++ D L+ + LHS EEL
Sbjct: 3262 GLELLKQTTGDEVLI-IQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC 3320
Query: 2872 RWSD-------------MSGDSSA--------TQKKLSKIKELIDS-REIGASRLSRVES 2909
W D + G+ ++ +K+ K L+DS E+ ++ L V
Sbjct: 3321 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPW 3380
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMA-LSEQE---F 2965
A E + A E + ++ + ++ ++Q + ++++ ++E E
Sbjct: 3381 RAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLM 3440
Query: 2966 SGQVAQLEQALEQFSALL---KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPR 3022
S +LEQ +Q SA L KT+ + +L K+ +++V+ HK I+ A +E
Sbjct: 3441 SLGDIRLEQ--DQTSAQLQVQKTFTME--ILRHKDIIDDLVKSGHK---IMTAC--SEEE 3491
Query: 3023 TEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLC-LQASKGCQ-NKEQILQQRFRKAF 3080
+ +K +L++ ++K Y+ +C + + + Q + Q L +F + +
Sbjct: 3492 KQSMKKKLDK-----------------VLKNYDTICQINSERYLQLERAQSLVNQFWETY 3534
Query: 3081 RDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEF--LSE--SENGQHKLNMMLSKGE 3136
+ WL T + +P E T Q+ +E L E +E+ H M + +
Sbjct: 3535 EELWPWLTE---TQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3591
Query: 3137 LLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWL 3196
LL L+ + IQ K AA + ++ ++ AL+ Q F + I + L
Sbjct: 3592 LLE--LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 3649
Query: 3197 SKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL------WEG 3250
+ + + + + ++ + + + ++V ++ +P LK++ +++ +
Sbjct: 3650 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 3709
Query: 3251 QAASKSFRHRVSQLSSQYLALSNLTKEKVSRL-------DRIVAEHNQFSLGIKELQDWM 3303
++K+ + ++ Q+ + + L +E+ ++L ++ +H + IK+ QD++
Sbjct: 3710 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 3769
Query: 3304 TDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGI 3363
D P D SV+ + E + + ++ +++ G ++
Sbjct: 3770 RDLE-------DPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDK 3822
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
P +++ + + W SL A +LE A+ YQDG++ W+D L
Sbjct: 3823 PIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMS 3882
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIE-------VKGAGMTEHYVTQLELQDL 3476
+L + + K E +E + K ++ + Q L +L
Sbjct: 3883 PIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMEL 3942
Query: 3477 QERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHE 3536
+ + +++ER K E + ++Q L WL + L + + GD E
Sbjct: 3943 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4002
Query: 3537 TTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE---DRALESLRQDWQAYQHRL 3593
L LQ Q+ + +V D+I S + LE L Q WQ +
Sbjct: 4003 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4062
Query: 3594 SETRTQFNNVVNKLRLMEQKFQQVDEWL-----------------KTAEEK-KWHEEVTA 3635
+ + Q + + + + + + + +WL +TA+E+ H EV A
Sbjct: 4063 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4122
Query: 3636 YRDEVEE----VGARAQEILDE--SHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEI 3689
+ EE + + Q++L + + L +++++ ++ E+ LEE +
Sbjct: 4123 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4182
Query: 3690 QSLEESESSLSSYSDWYGSTHKNFKNVATKIDKV-DTVMMGKKLKTLEVLLKDMEKGHSL 3748
E +SL + +W + NVA++ + DTV+ ++ +V ++
Sbjct: 4183 NLAMEFHNSLQDFINWLTQAEQTL-NVASRPSLILDTVLF--QIDEHKVFANEVNSHREQ 4239
Query: 3749 LKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSD 3808
+ + G + ++ + ++ + + +++ + + +L+ AK+F +
Sbjct: 4240 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4299
Query: 3809 KCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEAL 3868
L +W+ E ++ L E + + K QL+++K Q+++ + + G +L
Sbjct: 4300 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359
Query: 3869 LELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQ 3928
E +L D D L+ D D L+ L+ K DT+ G+ + Q
Sbjct: 4360 KE---KTSLAD--DNLKLD-------------------DMLSELRDKWDTICGKSVER-Q 4394
Query: 3929 AKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL 3988
KL++ + Q T D+ A+ R+ L + H D + A Q +L
Sbjct: 4395 NKLEEALLFSGQFT-DALQALIDWLYRVEPQLAEDQPVH-GDIDLVMNLIDNHKAFQKEL 4452
Query: 3989 EPSPQPPLSRAEAIKQVKHFRALQEQARTYLD--------LLCSMCDLSNASVKTTAKDI 4040
K+ +AL+ AR ++ + M +LS A I
Sbjct: 4453 G-------------KRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSI 4499
Query: 4041 QQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL--ELNIAQ 4098
+ + +E L QA EE + L +L +A+Q L R H L + + +
Sbjct: 4500 SK-QTRLEAALRQA-------EEFHSVVHALLEWLAEAEQTL----RFHGVLPDDEDALR 4547
Query: 4099 NMVSQVKDFVKKLQSKQASVN 4119
++ Q K+F+KKL+ K+A +N
Sbjct: 4548 TLIDQHKEFMKKLEEKRAELN 4568
Score = 264 bits (674), Expect = 3e-69
Identities = 856/4706 (18%), Positives = 1829/4706 (38%), Gaps = 694/4706 (14%)
Query: 2615 LLRMTKEKLRSCQVA--LQEHEALEEALQSMWFWVKAIQ---DR------LACAESTLGS 2663
L+++ K L+S + L E E + +Q + WV +Q DR L ES L +
Sbjct: 255 LMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLEN 314
Query: 2664 KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWAD 2723
+ + + + + L E+++ + + +L L+ +A
Sbjct: 315 HKNVHRAIEEFESSLKEAKISEIQMTAPL--------------KLTYAEKLHRLESQYAK 360
Query: 2724 IMSSSVHAQSTLESVISQWNDYVERKNQLEQWM-ESVDQKIEHPLQPQ-PGLKEKFVLLD 2781
++++S + + L+++ +++V R W+ E ++++ + + + K
Sbjct: 361 LLNTSRNQERHLDTL----HNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHA 416
Query: 2782 HLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRK 2841
L L + E++ +++ + + L E + + ++TQ++ I+ + +
Sbjct: 417 ELMRELDQKEENIKSVQEIAEQL--LLENHPARLTIEAYRAAMQTQWSWILQLCQ----C 470
Query: 2842 VEEIVKDHLMYLDAVH---EFTDWLHSAKEELHRWSDMSGDSSA------TQKKLSKIKE 2892
VE+ +K++ Y + + E TD+L + K+ + R SS Q+ + + +E
Sbjct: 471 VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 530
Query: 2893 LIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSC-L 2951
L+ + A+ + + +++ +N S C L + D++Q E ++++ C L
Sbjct: 531 LLQYKSTIANLMGKAKTIIQLKPRN---SDCPLKTSIPIKAICDYRQIEITIYKDDECVL 587
Query: 2952 ENLVSQMALSEQEFSGQVAQL-----------EQALEQFSALLKTWAQQLTLLEGKNTDE 3000
N + +G A + ++A++ + + + + LTL + +
Sbjct: 588 ANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINM 647
Query: 3001 EIVECWHKGQEILDALQKAEPRT-------------EDLKSQLNELCRFSRDLSTYSGK- 3046
+ V WH +D ++ + + +L+S+ + S++ +SG
Sbjct: 648 KSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD 707
Query: 3047 VSGLIKEYNCLCLQ------ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDI 3100
++ L KE N +C Q S + +E+ + + R+ + L N + +
Sbjct: 708 ITQLEKEVN-VCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRT 766
Query: 3101 PQNISEVSTSLQKIQE---FLSESENGQHKLNMMLSK-GELLSTLLTKEKAKGIQAKVTA 3156
P ++ S+ +I E E E + L + +K E S +++++
Sbjct: 767 PLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNV 826
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKT--EKMVHESSNRLYDLP 3214
++ +S L+ + + +K+ + + ++ + +K E+ V N + +L
Sbjct: 827 VLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLI 886
Query: 3215 AKRRE-QQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSN 3273
+ ++ + ++ + H E +L + K + +++ K+++ R
Sbjct: 887 STLKQWRSEVDEKRQVFHALEDELQKAKAISDEMF------KTYKERDLDFDWH------ 934
Query: 3274 LTKEKVSRL-DRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEA 3332
KEK +L +R H Q +++L+ + D+Y HP D
Sbjct: 935 --KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTY-HPLDDW------------ 979
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLE 3392
++Q + Q K +Q PE T+ QL K +L + I K
Sbjct: 980 ---IQQVETTQRK---------IQENQPENSKTLATQLNQQK-----MLVSEIEMKQSKM 1022
Query: 3393 GALSKWTS-YQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLS--- 3448
K+ Y V+ + + A ++ ++ + R M A L+ +E +
Sbjct: 1023 DECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRR---RMQSSADLIIQEFMDLRT 1079
Query: 3449 -YSSL--LETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505
Y++L L T +K AG + L+ L+E ++++E KE V K+++L +
Sbjct: 1080 RYTALVTLMTQYIKFAGDS--------LKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1131
Query: 3506 RDLKAFEV---------------------WLGQEQEKLDQYSVLEGDAHTHETTLRDLQE 3544
+ LK E L + + + + GD T E ++
Sbjct: 1132 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1191
Query: 3545 LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN-- 3602
++ L + L ++ SG + E++ + +Q+++ + + TQ N
Sbjct: 1192 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRL 1251
Query: 3603 -------VVNKLRLMEQKFQQVDEWLKT---------AEEKKWHEEVTAYRDEVEEVGAR 3646
++ + +K+Q E L+ AE K E ++ E++
Sbjct: 1252 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFL--KENGEKLSQE 1309
Query: 3647 AQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEE-----IQSLEESESSLSS 3701
+ ++++ +++ C+ L + L + EE ++ LEES++ + +
Sbjct: 1310 DKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIEN 1369
Query: 3702 YSDWYGSTHKNFKNVATKIDKV----------------------------DTVMMGKKLK 3733
DW + K+ + TK +V +T + G+
Sbjct: 1370 LLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGT 1429
Query: 3734 TLEVLLKDMEKGHS--------------LLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
T E L + +K + +SA+ E+ +YL E E+L+K +M
Sbjct: 1430 TQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----NM 1485
Query: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
++LK T E EK + L ++ L ++ A+Y E H ++ + EL +A
Sbjct: 1486 KELKVHYETALAES---EKKMKLTHSLQEE---LEKFDADYTEFEHWLQQSEQELENLEA 1539
Query: 3840 ----------QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQ 3889
+L + KS + V+SH+ ++ + G +LE + + +D
Sbjct: 1540 GADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRD------GGKV 1593
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
D + + + ++ DR +L K + L D + + H + A
Sbjct: 1594 DTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDK------YQHYE------DAS 1641
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFR 4009
C + Q+ E KH+S + +Q LE + + + Q
Sbjct: 1642 CGLLAGL-QACEATASKHLSEPIAVDP-----KNLQRQLE---ETKALQGQISSQQVAVE 1692
Query: 4010 ALQEQARTYLDLLCSMCDLSNASVKTT----------AKDIQQTEQTIEQKLVQAQNLTQ 4059
L++ A LD S+ N KT +K + + + ++ L ++ ++
Sbjct: 1693 KLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQD 1752
Query: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119
G +E+ + L++ Q L Q+++S+ + + +Q+S+N
Sbjct: 1753 GLDEMLDWMGNVESSLKEQGQV---------PLNSTALQDIISKNIMLEQDIAGRQSSIN 1803
Query: 4120 TIIEKVNKLTKKEE----SPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
+ EKV K + + S ++ L+ ++ + + + EE + + +
Sbjct: 1804 AMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLS 1863
Query: 4176 NVVEVFLEKFT---TEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMI 4232
++ FLE T TE D + E + E+ + E K +E L +++
Sbjct: 1864 EKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFL----EHKKHLEVLHSLLKEIS 1919
Query: 4233 EHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQ 4292
H DK LV E+T++L +++ ++ED IK K + + E+L+ Q + L W +E
Sbjct: 1920 SHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKET 1979
Query: 4293 -------QPNI-AEAL------------KQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
QP+ AE L K S Q + +++C+ + A K+
Sbjct: 1980 TKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKA 2039
Query: 4333 L--IKDADRVM-------------ADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYL 4377
+ +K V+ A+ GL I+K ++D L L+ + L
Sbjct: 2040 IAAVKSGGAVLNGEGTATNTEEFWANKGLTS---IKKDMTDISHGYEDLGLLLKDKIAEL 2096
Query: 4378 NKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD---VSKQVKTCKSAQASLKT 4434
N LS K Q A Q Q K + P D V QV+ KS +A LK
Sbjct: 2097 NTKLS-KLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQ 2155
Query: 4435 YQNEVTGLWAQGRELMKEVTE-QEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSR 4493
N+V L + EL++E + E L E+ S + + Q R Q+LE++ +
Sbjct: 2156 NVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2215
Query: 4494 KHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQ----SPEYENLLL 4549
F+ + WL + +++ L + + L+TQ + Q +L++ P+YE L
Sbjct: 2216 TQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTA 2275
Query: 4550 T----LQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEY 4605
L R G+ PSL + + E+L A+ ++++ + D+ + +AI+ +Y
Sbjct: 2276 AGQGILSRPGED--PSLRGI----VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQY 2329
Query: 4606 ASLIELTTQSLSELEAQFLRMSKVPT-----DLAVEEALSLQDGCRAILDEVAGLGEAVD 4660
SL+ + LS+L+ + V T + +E A ++ + ++ +
Sbjct: 2330 QSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCE 2389
Query: 4661 ELNQ-KKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQL 4719
+L+ KE + Q + +L + ++++ E V L+ ++ + ++M +
Sbjct: 2390 DLSALVKEEYLKAELSRQLEGIL---KSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF 2446
Query: 4720 ERQLKSVKEEQSK---VNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD 4776
+ L + KEEQ+K ++ + E +K + + +L + ++ E+L L
Sbjct: 2447 QAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL--LK 2504
Query: 4777 PLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSID----FQTEMSRSLDWLRRV 4832
EKA Q+Q +K + V E E+++ +S++ ++ ++ W+ +
Sbjct: 2505 TQGSEKAALQLQ--LNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKC 2562
Query: 4833 KAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKA---KELIS 4889
+ L + L+ + + I K++ Q+E+ ++ L++ + KE+++
Sbjct: 2563 QNNLE-EIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVT 2621
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAG 4949
D SL + ++ + E L +++ L + + + + +V + + L+ A+E L +
Sbjct: 2622 -DENKSLIQKVDM---VTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIH- 2676
Query: 4950 NGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATL--DPLIKPT---GKEDLEQKV 5004
D ++ ++ T+ + L+ L L D +++ + G D+ +V
Sbjct: 2677 ---DSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQV 2733
Query: 5005 ASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS 5064
++ +S+ + L+ +Q E+ + + +L + + +
Sbjct: 2734 ETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA- 2792
Query: 5065 HEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ-------LEKTGNDASKATLSRSMTTV 5117
E L + K + E ++A + A++ E+T D + R + +
Sbjct: 2793 ----ETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDL--VGIKRDLEAL 2846
Query: 5118 WQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELL 5177
++ +L AQ +E+ +E + F +K+K+ + ++ + ++ ++ E
Sbjct: 2847 SKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEH---EESQGPVGMETE 2903
Query: 5178 TLLEYHDTF-VLELEQQQSALGMLRQQTLSMLQDG---AAPTPGEEPPLMQEITAMQDRC 5233
T+ + + F V + E+ + G +QQ ++ L G +A L ++ + R
Sbjct: 2904 TINQQLNMFKVFQKEEIEPLQG--KQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARW 2961
Query: 5234 LNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGN---PTIE---IDAQLE 5287
+ +KV +++ L + + S+ W+ +T+E + N P+ E + AQ++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQ 3021
Query: 5288 ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVA-LDLK---IRDQIQ 5343
E Q LL + R++ ++ + + EK T P++ L +++ LD + + ++ +
Sbjct: 3022 E-QKLLQRLLDDRKSTVEVIKREGEKI--ATTAEPADKVKILKQLSLLDSRWEALLNKAE 3078
Query: 5344 DKIKEVEQSKATSQELSRQIQKLAKDLTTILTKL------KAKTDNVVQAKTDQKVLGEE 5397
+ +++E +Q+ ++ L + LTTI +L + + + K L ++
Sbjct: 3079 TRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDD 3138
Query: 5398 LDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQ-AENRLSKLNQAAS 5456
+ N L + + Q + + K + + +++ I++ + +R L QA
Sbjct: 3139 IINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC 3198
Query: 5457 HLEEYNEMLELILKW-------IEKAKVLAHGTIA-WNSASQLREQYILHQTLLEESKEI 5508
+ + + E ++ W + K V + T W S+LR +L + +L + +
Sbjct: 3199 NAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELR---VLQEDILLRKQNV 3255
Query: 5509 DSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEA 5568
D L E L+ T +V + + E ++ K + D AK +++
Sbjct: 3256 DQALLNGLELLKQTT--------GDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQ 3307
Query: 5569 ELKKLQAALEQAQATLTSPEVGRLSLKEQL----------SHRQHLLSEMESLKPKVQAV 5618
++L + E+ L EV LS + Q+ + L E ++ K + ++
Sbjct: 3308 LARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSL 3367
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEM-- 5676
SAL A L E + T Q+ + AA+++ +Q++Q
Sbjct: 3368 NEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADA 3427
Query: 5677 ---------KHLQQLIEGAHREIEDKPVATSNIQE-LQAQISRHEELAQKIKGYQEQIAS 5726
K L L G R +D+ A +Q+ +I RH+++ + +I +
Sbjct: 3428 ELSWITETEKKLMSL--GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMT 3485
Query: 5727 LNSKCKMLTMKAK--------------HATMLLTVTEVEGLAEGTEDLDGELLPTPSAHP 5772
S+ + +MK K ++ L + + L + EL P +
Sbjct: 3486 ACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQ 3545
Query: 5773 SVVMMTAGRC------------HTLL-------SPVTEESGEEGTNSEISSPP---ACRS 5810
S++ H L P ++ + G SP + +
Sbjct: 3546 SIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQE 3605
Query: 5811 PSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLE-----PSATAK 5865
A+T S ++ +A++ + + + + H E E +E PS +A+
Sbjct: 3606 KYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAE 3665
Query: 5866 LGDLQRSWETLKNVI--SEKQRTLYEALERQ-----------------QKYQDSL----- 5901
+ ++ KNV EK + LYE L+++ + QD L
Sbjct: 3666 VEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVF 3725
Query: 5902 --QSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVS 5959
++I T +E E KL + E E +H +L+ I QD I +L
Sbjct: 3726 IWENIHTLVEEREAKLLDVME---LAEKFWCDHMSLIVTIKDTQDFIRDL---------- 3772
Query: 5960 ESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN--DQLEEQRQEQALQRY 6017
E DP S + E TIR + G ++ L+ +N +L E
Sbjct: 3773 EDPGIDP-------SVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV 3825
Query: 6018 RCEADELDS-WLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVE----IEQKVVALSEL 6072
+ DEL+S W KA D + +E M Q D + + K+ ++S +
Sbjct: 3826 KKSIDELNSAWDSLNKAWKD-RIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 3884
Query: 6073 SVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVD 6132
E + K + E+L +E++R H +L ++ +E ++
Sbjct: 3885 GTDLETV--------KQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT-- 3934
Query: 6133 LTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHS 6192
VQ+ L + + W + + +Q +LE L + G+ QH+
Sbjct: 3935 --------VQDPLMELKLIWDSLEERIINRQHKLEGAL----------LALGQ---FQHA 3973
Query: 6193 AAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQN--VLEQEQ 6250
E +LS++ + G+ + E ++ K +LQN + Q
Sbjct: 3974 LDELLAWLTHTEGLLSEQKPVGGDPKAIEIEL------------AKHHVLQNDVLAHQST 4021
Query: 6251 EQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQ---SIH 6307
+ + N L+ ++ S + + L+ LNQ ++ V ++ K+Q ++
Sbjct: 4022 VEAVNKAGNDLIE-------SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALR 4074
Query: 6308 LEQKLYDGVSATSTWLDDVEERLFVATAL--LPEETETCL-FNQEILAK-DIKEMSEE-- 6361
+ + + WL D E L + L LPE + L + E+ A + KE + +
Sbjct: 4075 QAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSL 4134
Query: 6362 MDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQND 6421
M K + + ++ P++ + I+ + L + +++ +N+R +++E L + F N
Sbjct: 4135 MQKGQQMLARC-PKSAETN--IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNS 4191
Query: 6422 LKVLFTSLADNKYIILQKLANVFEQP------VAEQIEAIQQAEDGLKEFDAGIIELKRR 6475
L+ L ++ NV +P V QI+ + + + IIEL +
Sbjct: 4192 LQDFINWLTQ-----AEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4246
Query: 6476 GDKLQVEQPSMQE------LSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLAD 6529
G L+ L +Q +++++ + R L+ Q+ A L +
Sbjct: 4247 GTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLME 4306
Query: 6530 LLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQ--- 6586
LE EK + I + ++I+ L +HKE+ + L + + +T R S +
Sbjct: 4307 WLEE-SEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4365
Query: 6587 -----KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI 6641
K +EL + + ++ +R +LE L + Q L L VE +
Sbjct: 4366 ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQL 4425
Query: 6642 PSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQL 6698
V + D +++ I ++ + L + + Q L R LI S D ++ Q+
Sbjct: 4426 AEDQPVHGDIDLVMNLIDNHKAFQKELGK-RTSSVQALKRSARELIEGSRDDSSWVKVQM 4484
Query: 6699 NQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVP 6758
+L W + + RLE L+ + S L+ WL A+ L F +P
Sbjct: 4485 QELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRF----HGVLP 4540
Query: 6759 QELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDT-ATLRSELSRIDSQW 6817
+ + +R ++ EF K+++ + + + + G+ +L + D+ T++ ++ I +++
Sbjct: 4541 DDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARF 4600
Query: 6818 TDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVI-QKDEDNIKNSIGYKAIH 6876
++L Q++L + + + +++W+ E + KD++ I I + +
Sbjct: 4601 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEI--EEVK 4658
Query: 6877 EYLQKYKGFKIDINCKQLTVDFVNQS 6902
+ +++ F ++ KQ VD V ++
Sbjct: 4659 ALIAEHQTFMEEMTRKQPDVDKVTKT 4684
Score = 245 bits (626), Expect = 1e-63
Identities = 593/3347 (17%), Positives = 1290/3347 (38%), Gaps = 356/3347 (10%)
Query: 544 EQLLQNYVSF-IENSKFFEQYEVTYQILKQTAEMYVKADG---SVEEAENVMKFMNETTA 599
E L Q Y ++ K Q++ I Q+A++ ++ G S EE E + K M E
Sbjct: 1432 ENLNQQYQKVKAQHEKIISQHQAVI-IATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1490
Query: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPH 659
+ E + + +++ + WL+ +E+ L E D +
Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1550
Query: 660 WIQQHTAMND-------------AGNFLIETCDEMVSRD------------LKQQLLLLN 694
+Q + D +GN ++E RD ++++L
Sbjct: 1551 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1610
Query: 695 GRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNV 749
R+R L+ + D+ + + L A A K LSEP+ V N+
Sbjct: 1611 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNL 1670
Query: 750 KLLIQDLEDIEQRVPVMDAQYKIITKTAHLI---------------------------TK 782
+ +++ + ++ ++ + + KTA ++
Sbjct: 1671 QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLS 1730
Query: 783 ESPQEEGKEMFATMSK-------LKEQLTKVKECYSPLLYESQQLLIPLEE--------- 826
+S E +++ T+++ L E L + S L + Q +PL
Sbjct: 1731 KSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ---VPLNSTALQDIISK 1787
Query: 827 ---LEKQMTSFYDSLGKINEII-------------TVLEREAQSSALFKQ---KHQELLA 867
LE+ + S+ +NE + ++ + SA F + KH+E LA
Sbjct: 1788 NIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLA 1847
Query: 868 CQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWK 926
E K + L E S+ +Q F+ T + L D + + ++ Q + + K
Sbjct: 1848 KMEELKTKVELFENLSEKLQTFLETKTQALTEVDVP--GKDVTELSQYMQESTSEFLEHK 1905
Query: 927 KHVETNSRLMKKF------EESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQ- 979
KH+E L+K+ + LEK ++++ E + +E T QLD
Sbjct: 1906 KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAF 1965
Query: 980 RVLNAFLKA-CDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRF 1038
+VL LK+ E T +P + E + K + K LQ + ++
Sbjct: 1966 QVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGIS 2025
Query: 1039 LASVEECRTELDRETKLMPQEGS----EKIIKEHRVFFSDKGPHHLCEKRLQL---IEEL 1091
L ++ T + + G+ E F+++KG + + + E+L
Sbjct: 2026 LCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDL 2085
Query: 1092 CVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1151
+ L + +T + +E +A+ +K+ + KW+ + + + T
Sbjct: 2086 GLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTD--TEAVKTQV 2143
Query: 1152 TQLKGIKGEAIDTANH-GEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQ 1210
Q K + E N E+K + E+ E W ++LTE+ S+ + Q
Sbjct: 2144 EQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRW----KQMLTEIDSKWQELNQ 2199
Query: 1211 --GDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEK 1268
D KL S L T VE L + + KE++ + L L + Q ++
Sbjct: 2200 LTIDRQQKLEESSNNL-TQFQTVEAQLKQW---LVEKELMVSVLGPLSIDPNMLNTQRQQ 2255
Query: 1269 ILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPD-----RG--HEEL 1321
+ Q+LL A ++ +Q+ A QG P RG E+L
Sbjct: 2256 V----------QILLQE-------FATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2298
Query: 1322 RKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL-- 1379
+ D L + I + K T ++++R L S + LS SSL
Sbjct: 2299 AAVTQKWDSLTGQLSDRCDWIDQAIVK----STQYQSLLRSLSDKLSDLDNKLS-SSLAV 2353
Query: 1380 ----ESLSSELEQTKEFSKRTESIAVQ---AENLVKEASEIPLGPQNKQLLQQQAKSIKE 1432
++++ +LE ++ + + Q A+ L ++ S + K L +Q + I +
Sbjct: 2354 STHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILK 2413
Query: 1433 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1492
K +E E ++ ++ F W+ K++E N S+ +D+ S
Sbjct: 2414 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESL 2473
Query: 1493 IKVTIQEIESKLSSIVGLEE----EAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQ 1548
IK ++ L++ + E E ++ E A ++ +L I+ + + +
Sbjct: 2474 IK-DHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVK 2532
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATE------TYKVLQEH 1602
E + L + K++E + + + + ++ L IK C E K LQ+
Sbjct: 2533 ERENKLKESLEKALKYKEQVETLWPWIDKCQNNLE-EIKFCLDPAEGENSIAKLKSLQKE 2591
Query: 1603 MDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLA 1662
MD + L + TA S + ++++ E +L Q+ + + + ++ LEN+
Sbjct: 2592 MDQHFGMVELLNN-TANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQ 2650
Query: 1663 HWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSK 1722
++ ++ +K S ++ + +++ + L QA N+ ++ K
Sbjct: 2651 KFKEFQE------------VSKESKRQLQCAKEQLDIHDSLG-SQAYSNKYLTMLQTQQK 2697
Query: 1723 LLQ------------LKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSV 1770
LQ ++ + + + L +E + + L Q ++++ +FL++
Sbjct: 2698 SLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETK 2757
Query: 1771 VAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSL 1830
+ F + F EL + + + + A T K + E+ K L+ L
Sbjct: 2758 LQGIGHFQNTIREMFSQFAEFDDELDSMAPVG----RDAETLQK----QKETIKAFLKKL 2809
Query: 1831 QGHLAKLGSLGRAEDLHL--------LQGKAEDCFQLFEEASQVVERRQL-------ALS 1875
+ +A + + + L L G D L ++ +++++R Q +
Sbjct: 2810 EALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIK 2869
Query: 1876 HLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDG 1935
L EF S +L++ + E+ + E++ I + LN K ++
Sbjct: 2870 RLEEFYSKLKEFSILLQKAEEHEESQGPVGM-ETETINQQLNMFKVFQKE------EIEP 2922
Query: 1936 ILSKAQYHLKIGSSEQRTSCRATADQ-LCGEVERIQNLLGT-KQSEADALAVLKKA---- 1989
+ K Q +G +++ ++T+ Q L +++ + T + A A L++A
Sbjct: 2923 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC 2982
Query: 1990 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2047
FQD E LL + D EE ++ + ++ +++ L+ L+ + + +K
Sbjct: 2983 GRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKR 3042
Query: 2048 KAKQIA-QKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVS 2106
+ ++IA + A ++ ++++ L+ W+ Q G+ + +++ ++
Sbjct: 3043 EGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLN 3102
Query: 2107 KVLENASSVIVTRTTIKDQ-EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKK 2165
+ L +V I Q L+ ++H+ ++ + K L S G+ L K
Sbjct: 3103 EWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSL-----K 3157
Query: 2166 IHSS--DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIE--GWSN 2221
+ SS D +V++ ++ + ++++ EK + L+ +L + + DE+E W N
Sbjct: 3158 VLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALC--NAKIFGEDEVELMNWLN 3215
Query: 2222 NCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLE----T 2277
++ + +S L + E L + +SE+ + L+ + L K N + L LE T
Sbjct: 3216 ----EVHDKLSKLSVQDYSTEGLWKQQSEL--RVLQEDILLRKQNVDQALLNGLELLKQT 3269
Query: 2278 PPDLQFIEADLMQKL-----EHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE 2332
D I D ++ + + K T+VAK TL+ + ++ ++ TW KVE
Sbjct: 3270 TGDEVLIIQDKLEAIKARYKDITKLSTDVAK-TLEQALQLARRLHSTHEELCTWLDKVEV 3328
Query: 2333 SLMN-----CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGR 2387
L++ E +A + K+++KE ++ ++ + S E ++L E L +
Sbjct: 3329 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3388
Query: 2388 AMTGLIKKHEAVSQLCSKTQASLQESL--EKHFSESMQEFQEWFLGAKAAAKESSDRTGD 2445
+ +++ VS ++ + ++ + F ++ W + D +
Sbjct: 3389 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3448
Query: 2446 SKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQA 2505
A+L + + + +D + + G + S++ S+++++ K + +
Sbjct: 3449 QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDT 3508
Query: 2506 FLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVH 2565
+ + L+ S + F + + +L W+ E + + + ++ E H
Sbjct: 3509 ICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEH 3568
Query: 2566 KVEMFLGELLAA-RESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLR 2624
+ L EL+A + +DK+++ G L E G EG + + L KE ++
Sbjct: 3569 RQ---LRELIAEHKPHIDKMNKTGPQLLELSPG---EGFSIQEKYVAADTLYSQIKEDVK 3622
Query: 2625 SCQVALQE--------HEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQD 2676
VAL E H+ +++ L+S+ + I +RL S + +++++S+ ++
Sbjct: 3623 KRAVALDEAISQSTQFHDKIDQILESL----ERIVERLRQPPSISAEVEKIKEQISENKN 3678
Query: 2677 ILLMKGEGEVKLNMAIGKGEQALRSSNKEGQ----RVIQTQLETLKEVWADIMSSSVHAQ 2732
+ + + + +GE+ + S + + +Q +L+ + +W +I + +
Sbjct: 3679 VSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738
Query: 2733 STLESVISQ----WNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILS 2788
+ L V+ W D++ ++ + + + + P +++ + ++I
Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQ----EAAETIRE 3794
Query: 2789 EAEDHTRALHRLIAKSRELYEK--TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIV 2846
E + L +I EL D+ + +EL + ++ + K+++ K+EE +
Sbjct: 3795 EIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAM 3854
Query: 2847 KDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELID---SREIGASR 2903
+ + Y D + DW+ A +L S + D ++++ ++K+ ++I R
Sbjct: 3855 QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMER 3914
Query: 2904 LSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQ 2963
L+ L +K+ T S + + L+ W E+ + Q LE + +
Sbjct: 3915 LNHQAELL--LKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLAL----- 3967
Query: 2964 EFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3023
Q + AL++ A L L+ + D + +E +L A T
Sbjct: 3968 ------GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4021
Query: 3024 -EDLKSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRK 3078
E + N+L S + S K+ L + + + + + Q + L+Q F
Sbjct: 4022 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHG 4081
Query: 3079 AFRDFQQWLVNAK---ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG 3135
D QQWL + + + + +P+ E L E + E + ++ KG
Sbjct: 4082 EIEDLQQWLTDTERHLLASKPLGGLPETAKE---QLNVHMEVCAAFEAKEETYKSLMQKG 4138
Query: 3136 ELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDW 3195
+ + K I + KE W++ + L+++++ LE +F S + +W
Sbjct: 4139 QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINW 4198
Query: 3196 LSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL--WEGQAA 3253
L++ E+ ++ +S L + + + E++ + Q+ L + L + +
Sbjct: 4199 LTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQD 4258
Query: 3254 SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSY 3313
++ + + S++ + E+ LD QF +L +W+ ++ LDS
Sbjct: 4259 VVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSE 4318
Query: 3314 CHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS-PEGIPTIQQQLQS 3372
+D + ++ + + K G S+ + TS + + L
Sbjct: 4319 LEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSE 4378
Query: 3373 VKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDK 3432
++D W ++ + +++LE AL + D ++ W+ +E L E + H ++
Sbjct: 4379 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4438
Query: 3433 TTMLGKAKLLNEEVLSYSSLLETIE------VKGAGMTEHYVTQLELQDLQERYRAIQER 3486
++ K +E+ +S ++ ++ ++G+ +V ++++Q+L R+ +
Sbjct: 4439 MNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWV-KVQMQELSTRWETVCAL 4497
Query: 3487 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3546
+ T+ E +R +E+ + A WL + ++ L + VL D T + +E
Sbjct: 4498 SISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFM 4557
Query: 3547 VHCAEGQALLNSVLHTREDVI----PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNN 3602
E +A LN + V+ P I + + +R ++ + + + +
Sbjct: 4558 KKLEEKRAELNKATTMGDTVLAICHPDSITTIK-HWITIIRARFEEVLAWAKQHQQRLAS 4616
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQE 3649
+ L ++ + + WL+ AE ++ E+EEV A E
Sbjct: 4617 ALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAE 4663
Score = 239 bits (611), Expect = 7e-62
Identities = 867/4747 (18%), Positives = 1760/4747 (37%), Gaps = 818/4747 (17%)
Query: 2189 SEKLEENMDRLRVSLSIWDDVLSTRDEIE------GWSNNCVPQMAENISNLDNHLRAEE 2242
S L++N+ +++ D+L+ DE++ W ++ +P + S+L+NH
Sbjct: 265 SSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSD-LPSVE---SHLENHKNVHR 320
Query: 2243 LLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT--- 2299
++EFES +K +K+++++ + P L + E + ++AK +
Sbjct: 321 AIEEFESSLKE---------AKISEIQ-----MTAPLKLTYAEKLHRLESQYAKLLNTSR 366
Query: 2300 --EVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKV--KDIQKE 2355
E TL +F +++T ++N+ + EE + ++ T A KK ++ +E
Sbjct: 367 NQERHLDTLHNFVSRATNELIWLNE-----KEEEEVAYDWSERNTNIARKKDYHAELMRE 421
Query: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415
L ++ NI S QE L + H A L I+ + A Q L + +E
Sbjct: 422 LDQKEENIKSVQEIAEQLLLENHPARL---------TIEAYRAAMQTQWSWILQLCQCVE 472
Query: 2416 KHFSESMQEFQEWFLGAKAAA------------KESSDRTGDSKVLEAKLHDLQNILDSV 2463
+H E+ F E+F AK A K S DR+ LE + + + +
Sbjct: 473 QHIKENTAYF-EFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEEL 531
Query: 2464 SDGQSKLDAVTQEGQTLYA---------------------HLSKQIVSSIQEQITKANEE 2502
+S + + + +T+ + +I ++ AN
Sbjct: 532 LQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNS 591
Query: 2503 FQAFLK-------------QCLKDKQALQDCASELGSFEDQHRK-LNLWIHEME------ 2542
+A K C ++ E Q++ L LW HE
Sbjct: 592 HRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTLW-HESHINMKSV 650
Query: 2543 ----------ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLS 2592
+R N+ K +P + +V L L + E + SQ Q+ S
Sbjct: 651 VSWHYLINEIDRIRASNVASIKTMLPGEHQQV------LSNLQSRFEDFLEDSQESQVFS 704
Query: 2593 -EEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQ 2651
+ +E +C Q +Q LL+ + + + V + ++++ ++ +
Sbjct: 705 GSDITQLEKEVNVCKQY---YQELLKSAEREEQEESV----YNLYISEVRNIRLRLENCE 757
Query: 2652 DRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK---------GEQALRSS 2702
DRL T +D L + + +I + +K E E +L +G + A SS
Sbjct: 758 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELE-RLKDDLGTITNKCEEFFSQAAASSS 816
Query: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQK 2762
+ + L+ + +V++ + S+ + T+ V+ + L + E+ +
Sbjct: 817 VPTLRSELNVVLQNMNQVYS-MSSTYIDKLKTVNLVLKN----TQAAEALVKLYETKLCE 871
Query: 2763 IEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ- 2821
E + + ++ L +S + E AL + K++ + DE FK +
Sbjct: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAI----SDEMFKTYKER 927
Query: 2822 -----------EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
++L ++ ++ ++R +E I K Y D H DW+ +
Sbjct: 928 DLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQ 987
Query: 2871 HRWSDMSGDSSAT-QKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTE 2929
+ + ++S T +L++ K L+ E+ S++ + A + + T EL
Sbjct: 988 RKIQENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQ--YSATVKDYELQTMT 1045
Query: 2930 MQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ 2989
+A+ DS ++ + S L QEF +++AL+ Q
Sbjct: 1046 YRAM-------VDSQQKSPVKRRRMQSSADLIIQEFM-------DLRTRYTALVTLMTQY 1091
Query: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
+ D+L++ E + L+ + E +++L + +S
Sbjct: 1092 IKFAG-------------------DSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISK 1132
Query: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
+K+ +A K +K++I + + L ++ AK D + E
Sbjct: 1133 TLKDAE----KAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGD--KMTDEERN 1186
Query: 3110 SLQKIQEFLSESEN-----GQHKLNMMLSKGELL--------STLLTKEKAKGIQAKVTA 3156
L+K + L ES N +L + G++ KEK +GI +T
Sbjct: 1187 ELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQ 1246
Query: 3157 AKEDWKNFHSNLHQKESALENLKIQ------MKDFEVSAEPIQDWLSKTEKMVHESSNRL 3210
+ + +E K Q KD + SA+ + + + TE + E+ +L
Sbjct: 1247 TENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKL 1306
Query: 3211 YDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA------------QQLWEGQAASKSFR 3258
+ ++ ++ L E QLN E++ ++ E AA K
Sbjct: 1307 -----SQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLE 1361
Query: 3259 HRVSQLSSQYLALSNLTK--EKVSRLDRIVAEHN--QFSLGIKELQDWMTDAIH------ 3308
+++ + LSN+ K E+ + V E N F G + D ++
Sbjct: 1362 ESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLET 1421
Query: 3309 MLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVL-----QNTSPEGI 3363
+D T + + +K + + Q + + +I T+ VL Q SPE
Sbjct: 1422 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAV---IIATQSAQVLLEKQGQYLSPEEK 1478
Query: 3364 PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESE 3423
+Q+ ++ +K + + L+ + + + +F W+ E L E
Sbjct: 1479 EKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLE 1538
Query: 3424 RQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTE------------------ 3465
++ T L + K +E+V+S+ L I + G + E
Sbjct: 1539 AGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSAT 1598
Query: 3466 HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ-------RDLKAFEVWLGQE 3518
H Q +L +R+R++ + + LV +Q Y+ L+A E +
Sbjct: 1599 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1658
Query: 3519 ------------QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALL----NSVLHT 3562
Q +L++ L+G + + + L++ + + L N + T
Sbjct: 1659 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 1718
Query: 3563 REDVI------PSGIPQAEDRALESLRQ------------DWQA-------YQHRLSETR 3597
+D++ + + ++ +L + DW Q ++
Sbjct: 1719 LDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNS 1778
Query: 3598 TQFNNVVNKLRLMEQ-------KFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEI 3650
T ++++K ++EQ ++E +K E ++ + +++++ AR E
Sbjct: 1779 TALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSE- 1837
Query: 3651 LDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTH 3710
SH + + +L ++ +E + L E++Q+ E+++ + D G
Sbjct: 1838 --ASHKHKETLAKMEELKTK--------VELFENLSEKLQTFLETKTQALTEVDVPG--- 1884
Query: 3711 KNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAER 3770
K+ ++ + + + + K K LEVL HSLLK G + K L +
Sbjct: 1885 KDVTELSQYMQESTSEFLEHK-KHLEVL-------HSLLKEISSHGLPSDKALVLEKTNN 1936
Query: 3771 LRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
L K + KE+ T++++ + F K+L WI E + + + +P
Sbjct: 1937 LSK-------KFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPI-VQP 1988
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK-IDQLQSDYQ 3889
+ L K LQ+ P ++ V G +L L+ VT K I ++S
Sbjct: 1989 SFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGA 2048
Query: 3890 DLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAI 3949
L G A E L +++ K T I + L LK +
Sbjct: 2049 VLNGEGTATNTEEFWANKGLTSIK-KDMTDISHGYEDLGLLLKDKI-------------- 2093
Query: 3950 CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWL-----SAVQPDLEPSPQPPLSRAEAIKQ 4004
L +L K Q+ WL +A + P+P + ++Q
Sbjct: 2094 --------AELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQ 2145
Query: 4005 VKHFRA-LQEQARTYLDLLCSMCDLSNASVKT-TAKDIQQTEQTIEQKLVQAQNLTQGWE 4062
K F A L++ +L + +L + T A +Q I+ K W+
Sbjct: 2146 NKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSK----------WQ 2195
Query: 4063 EIKHLKSELWIYLQDADQQLQNMKRRHSELE---------------LNIAQNMVSQVKDF 4107
E+ L + L+++ L + ++L+ L+I NM++ +
Sbjct: 2196 ELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2255
Query: 4108 VKKLQSKQASVNTIIEKVNK-----LTKKEESPE-----HKEINHLNDQWLDLCRQSNNL 4157
V+ L + A+ E++ L++ E P +++ + +W L Q ++
Sbjct: 2256 VQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2315
Query: 4158 CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQER 4217
C ++ + ++ Y + + +K + + L+ S A ST H +A+ + Q+
Sbjct: 2316 CDWIDQAIVKSTQYQSLLRSLS---DKLSDLDNKLSSSLAVST--HPDAMNQQLETAQKM 2370
Query: 4218 KYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIK------RKIQVSVTN 4271
K I+ K Q K+ + L D LVKE+ E QLE ++K +K + V +
Sbjct: 2371 KQEIQQEKKQ-IKVAQALCEDLSALVKEEYLKAELS-RQLEGILKSFKDVEQKAENHVQH 2428
Query: 4272 LEELNVVQSRFQEL----MEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQ 4327
L+ +FQ++ W + ++ ++ S D+ ++L+ DH L A+
Sbjct: 2429 LQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQS 2488
Query: 4328 MLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQR----RKYLNKALSE 4383
+ + I + + ++ +E+ +Q L+ +++ + + V +R ++ L KAL
Sbjct: 2489 HMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKY 2548
Query: 4384 KTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLW 4443
K Q + ++ + Q + +I F CL P + + KS Q + + V L
Sbjct: 2549 KEQ-VETLWPWIDKCQNNLEEIKF----CLDPAEGENSIAKLKSLQKEMDQHFGMVELLN 2603
Query: 4444 AQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
L+ V E +K V + + L D V ++ + LE K F+E ++
Sbjct: 2604 NTANSLL-SVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKES 2662
Query: 4504 CHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLN 4563
L+ A E ++H L S Y N LT+ +T Q
Sbjct: 2663 KRQLQCA-----------KEQLDIHDSLG--------SQAYSNKYLTMLQTQQ------- 2696
Query: 4564 EVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEA-----ILAR-----KEYASLIELTT 4613
+ L AL Q ++ LA+D + ++ +L + +E+++L +
Sbjct: 2697 --------KSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD 2748
Query: 4614 QSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR--- 4670
+ S LE + + + E S LD +A +G + L ++KE +
Sbjct: 2749 EKCSFLETKLQGIGHFQN--TIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFL 2806
Query: 4671 --------STGQPWQPDKML--------HLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEK 4714
S + KM+ LV + L+ ++Q LL+ + ++ E
Sbjct: 2807 KKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEG 2866
Query: 4715 MCQQLERQLKSVK-------------EEQSKVNEETLPAEEKLKMY--------HSLAGS 4753
++LE +K E Q V ET ++L M+ L G
Sbjct: 2867 TIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGK 2926
Query: 4754 LQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMV 4813
QD + + + ++ A E H + K L + + + + ++
Sbjct: 2927 QQDVNWLGQGL---IQSAAKSTSTQGLE---HDLDDVNARWKTLNKKVAQRAAQLQEALL 2980
Query: 4814 QSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNAL 4873
FQ + L W+ + ++ + ++ +I++ ++ Q + + +
Sbjct: 2981 HCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVI 3040
Query: 4874 SHKEKEKFTKAKELISADLEHSLAELSELDGDIQEAL---RTRQATLTEIYSQCQRYYQV 4930
+E EK E AD L +LS LD + L TR L I Q++++
Sbjct: 3041 K-REGEKIATTAE--PADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET 3097
Query: 4931 FQAANDWLEDAQE-LLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLD 4989
+ N+WL ++ L+ G EE + H + ED ++ + LH V+
Sbjct: 3098 LEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHK---ALEDDIINHNKHLHQAVSIGQ 3154
Query: 4990 PLIKPTGKEDLEQKVASLELRSQ---RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELM 5046
L + +ED + + L+ + S ++ +LLQ+ + + E++ +
Sbjct: 3155 SLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWL 3214
Query: 5047 NDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDAS 5106
N+ KLS+ S ++ S+ ++ SE + L E I+ ++ Q G +
Sbjct: 3215 NEVHDKLSKLS-VQDYSTEGLWKQQSELRVL-------QEDILLRKQNVDQALLNGLELL 3266
Query: 5107 KATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGS 5166
K T + + + ++A +D K+ D V K E QL +L
Sbjct: 3267 KQTTGDEVLIIQDKLEAIKARYKDITKLSTD-----------VAKTLEQALQLARRL--- 3312
Query: 5167 SAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEI 5226
++ EL T L+ + +L E Q GEE
Sbjct: 3313 ---HSTHEELCTWLDKVEVELLSYETQ--------------------VLKGEE------- 3342
Query: 5227 TAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQL 5286
+ + K +K+E K+ + + +N E+ + L
Sbjct: 3343 ----------ASQAQMRPKELKKEAKNNKALLDSLN------------------EVSSAL 3374
Query: 5287 EELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKI 5346
EL R+ +EKM E E+Y L S+ Q E +R Q D+
Sbjct: 3375 LEL-----VPWRAREGLEKMVAEDNERYR-----LVSDTITQKVEEIDAAILRSQQFDQA 3424
Query: 5347 KEVEQSKATSQE---LSRQIQKLAKDLTTI-LTKLKAKTDNVVQAKTDQKVLGEELDGCN 5402
+ E S T E +S +L +D T+ L K T +++ K + ++L
Sbjct: 3425 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR----HKDIIDDLVKSG 3480
Query: 5403 SKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYN 5462
K+M + +K + + KK+ K+ + + + R +L +A S + ++
Sbjct: 3481 HKIMTACSEEEK---------QSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFW 3531
Query: 5463 EMLELILKWI-EKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQY 5521
E E + W+ E +++ LR+Q H+ L E E ++ M +
Sbjct: 3532 ETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQ 3591
Query: 5522 LTSVYCTEKMSQQVAELGRET--EELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
L + E S Q + +T ++++ +K R L +A +F ++ ++ +LE+
Sbjct: 3592 LLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLER 3651
Query: 5580 AQATLTSP-----EVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVA- 5633
L P EV + +KEQ+S +++ +ME L+P L ++ + E+++A
Sbjct: 3652 IVERLRQPPSISAEVEK--IKEQISENKNVSVDMEKLQP------LYETLKQRGEEMIAR 3703
Query: 5634 --SLPLCHAALRLQEEASRLQ------HTAIQQCNIMQAAVVQY-EQYEQEMKHLQQLIE 5684
+A +Q++ ++ HT +++ V++ E++ + L I+
Sbjct: 3704 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 3763
Query: 5685 GAH---REIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA 5741
R++ED + S +++ Q E + ++I G QE++ + + L
Sbjct: 3764 DTQDFIRDLEDPGIDPSVVKQQQ---EAAETIREEIDGLQEELDIVINLGSELIAACGEP 3820
Query: 5742 TMLLTVTEVEGLAEGTEDLD----GELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEG 5797
+ ++ L + L+ + A + V G + V G+
Sbjct: 3821 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG-LQAVFDWVDIAGGK-- 3877
Query: 5798 TNSEISSPPACRSPSPVANTDASVNQDI---------AYYQALSAERLQTDAAKIHPSTS 5848
S SP+ +V Q I AY Q + ERL H +
Sbjct: 3878 ----------LASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN------HQAEL 3921
Query: 5849 ASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKM 5908
++ E + + L +L+ W++L+ I +Q L AL ++Q +L + +
Sbjct: 3922 LLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 3981
Query: 5909 EAIELKLSESPEPGRSP---ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
E LSE G P E ++A+H L +++L Q + E + +L+ S +
Sbjct: 3982 THTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTV-EAVNKAGNDLIESSAGEE 4040
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ+ L VL +R + K ++Q L+ L RQ + + E ++L
Sbjct: 4041 ASN---LQNKLEVLNQRWQNVLEKTEQRKQQLDGAL-------RQAKG---FHGEIEDLQ 4087
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL T+ L + P + QL + E K L + +L
Sbjct: 4088 QWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPK 4147
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ---GTAQEKEESDVDLTATQSPGVQ 6142
+ +Q + LK ++ L++++ ++ A E S D
Sbjct: 4148 SAETNIDQ---DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI-------- 4196
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE 6202
WL QA T + SL L Q + E K V S E+I+ +
Sbjct: 4197 NWLTQAEQTLNVASRPSLILDTVLFQ-IDEHKVFANEVNSHREQIIELDKTGTHLKYFSQ 4255
Query: 6203 KPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLL 6262
K DV+ + + ++ +WE + Q + + L + ++ ++ + ++L+
Sbjct: 4256 KQDVVLIK--------NLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ--FHEAWSKLM 4305
Query: 6263 SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK--RQSIHLEQKLYDGVSATS 6320
+ + + ++ S L+ N +++ +Q K ++S+ + +YD + T
Sbjct: 4306 EWL--------EESEKSLDSELEIANDP-DKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4356
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
L E+T LA D ++ + + + ++ + ++ + +
Sbjct: 4357 --------------RSLKEKTS--------LADDNLKLDDMLSELRDKWDTICGKSVERQ 4394
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ +E+ L G+ + + ++++ +L + D+ ++ + ++K
Sbjct: 4395 NKLEEAL-LFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHK------- 4446
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
F++ + ++ ++Q + +E G R D V + MQELS ++ +
Sbjct: 4447 --AFQKELGKRTSSVQALKRSARELIEG-----SRDDSSWV-KVQMQELS---TRWETVC 4495
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHK 6560
+ S+++ L L ++ + L + L ++ + ++ ++ ++ L+D+HK
Sbjct: 4496 ALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLR-FHGVLPDDEDALRTLIDQHK 4554
Query: 6561 EYFQGLE 6567
E+ + LE
Sbjct: 4555 EFMKKLE 4561
Score = 224 bits (570), Expect = 4e-57
Identities = 485/2686 (18%), Positives = 1069/2686 (39%), Gaps = 226/2686 (8%)
Query: 507 LMKMEFLELKYRLLSLLVLAE--SKLKSWIIKYGRRESVEQLL------QNYVSFIENSK 558
L+K + EL +L L E S + W+ K + + Q + + +E +K
Sbjct: 2088 LLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNK 2147
Query: 559 FFE----QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSM 614
FE Q Q LK ++ + EA + + E ++W+ L+ +
Sbjct: 2148 SFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQK 2207
Query: 615 LEEVISNWDRYGNTVASLQAWLEDAE-------------KMLNQSENAKKDFFRNLPHWI 661
LEE +N ++ A L+ WL + E MLN + +
Sbjct: 2208 LEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRK 2267
Query: 662 QQHTAMNDAGNFLIETC--DEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-ADEMDRMKK 718
Q+ + AG ++ D + +K+QL + +W L ++ D+
Sbjct: 2268 PQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKST 2327
Query: 719 EYTDCVVTLSAFATEAHKKLSEPLEVS----FMNVKL-----LIQDLEDIEQRVPVMDA- 768
+Y + +LS ++ KLS L VS MN +L + Q+++ ++++ V A
Sbjct: 2328 QYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQAL 2387
Query: 769 --QYKIITKTAHLITKESPQEEG--KEMFATMSKLKEQLTKVKE-CYSPLLYE--SQQLL 821
+ K +L + S Q EG K K + + ++ C S ++ S+
Sbjct: 2388 CEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ 2447
Query: 822 IPLEELEKQMTSFYDSLGKINEIITVL-EREAQSSALFKQKH--QELLACQENCKKTLTL 878
L+ +++ + K++ + +++ + + S L Q H ++ +A EN L L
Sbjct: 2448 AWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN----LLL 2503
Query: 879 IEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKK 938
+GS+ + L+ + ++D +Q+ + + ++K +K+ VET + K
Sbjct: 2504 KTQGSEKAALQLQLNTIKTNWD--TFNKQVKERENKLKESLEKALKYKEQVETLWPWIDK 2561
Query: 939 FEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD--QRVLNAFLKACDELTDIL 996
+ + E++ L A EG + L + + F ++ N+ L C+ +++
Sbjct: 2562 CQNNLEEIKFCLDPA-EGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVV 2620
Query: 997 PEQEQQGLQE---AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRET 1053
++ + +Q+ +LH + L+ ++ E R L +E +LD
Sbjct: 2621 TDENKSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKE---QLDIHD 2677
Query: 1054 KLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLK 1113
L Q S K + + + + + ++ L + L L V D+ GT V L+
Sbjct: 2678 SLGSQAYSNKYL---TMLQTQQKSLQALKHQVDLAKRLAQDLVVE--ASDSKGTSDVLLQ 2732
Query: 1114 -ELRAAIDSTYRKLMEDPDKWKDYTSR-FSEFSSWISTNETQLKGIKGEAIDTANHGEVK 1171
E A ST + +++ + + + F + I +Q E A G
Sbjct: 2733 VETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDA 2792
Query: 1172 RAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEV 1231
++ K+ ET+ +L+ L ++S + A K + + LV + ++
Sbjct: 2793 ETLQ-------KQKETIKAFLKKLEAL--MASNDNANKTCKMMLATEETSPDLVGIKRDL 2843
Query: 1232 E---KMLSNFGDCVQYKE-----IVKNSLEELISGSKEV-----------QEQAEKILDT 1272
E K + D Q +E +K LEE S KE + Q ++T
Sbjct: 2844 EALSKQCNKLLDRAQAREEQVEGTIKR-LEEFYSKLKEFSILLQKAEEHEESQGPVGMET 2902
Query: 1273 ENLFEAQQLL-LHHQQKTKRISAKKRDVQ---QQIAQAQQGEGGLPDRGHEELRKLESTL 1328
E + + + + +++ + + K++DV Q + Q+ H +L + +
Sbjct: 2903 ETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEH-DLDDVNARW 2961
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGS--SHERFLSFSSLESLSSEL 1386
L + ++ ++Q L RF+ E+++ ++ T ++++ S + + + +++
Sbjct: 2962 KTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPS-AEFKVVKAQI 3020
Query: 1387 EQTKEFSKRTESIAVQAENLVKEASEI--PLGPQNKQLLQQQAKSIKEQVKKLEDTLEED 1444
++ K + + E + +E +I P +K + +Q + + + L + E
Sbjct: 3021 QEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETR 3080
Query: 1445 IKTMEMVKTKWDHFGSNFETLSVWITEKEKEL---NALETSSSAMDMQISQIKVTIQEIE 1501
+ +E + F E L+ W+T EK L + T +S ++ QI+Q K +I
Sbjct: 3081 NRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDII 3140
Query: 1502 SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1561
+ + QS + + +++KL + + E++E + + L
Sbjct: 3141 NHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNA 3200
Query: 1562 QKFEENLRKIQQSVSEFEDKLAVPIKICSSATE-------TYKVLQEHMDLCQALESLSS 1614
+ F E+ ++ ++E DKL+ + + +TE +VLQE D+ +++
Sbjct: 3201 KIFGEDEVELMNWLNEVHDKLS-KLSVQDYSTEGLWKQQSELRVLQE--DILLRKQNVDQ 3257
Query: 1615 AITAFSASARKVVNRDSCV--QEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELS 1672
A+ ++ + + + A++ +Y+DI + + + LE L +RL
Sbjct: 3258 ALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHE 3317
Query: 1673 SFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFS 1732
TWL++ E + S E + + +++ + L+ E + + L ++ +L
Sbjct: 3318 ELCTWLDKVEVELLSYETQVLKGEEASQAQMR-PKELKKEAKNNKALLDSLNEVSSALLE 3376
Query: 1733 VASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFL 1792
+ + ++ + + +ER+R + I +++ + + + QQFD+ + WI
Sbjct: 3377 LVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETE 3436
Query: 1793 SELQTTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
+L + +I + Q + L K E+ K + L K+ + E+ ++
Sbjct: 3437 KKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMK 3496
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL----SHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
K + + ++ Q+ R L L S + +F +++ L L + Q++ +
Sbjct: 3497 KKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTE-TQSIISQLPAPA 3555
Query: 1907 NESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSE--QRTSCRATADQLCG 1964
E + + + + Q + + +D + L++ E AD L
Sbjct: 3556 LEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYS 3615
Query: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2024
+++ EA + + F D+ +++L+S+E I ER + + ++++
Sbjct: 3616 QIKEDVKKRAVALDEAISQST---QFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQ 3672
Query: 2025 LRVFNQLEDELNSHEHELCWLKDKAKQI------AQKDVAFAPEVDREINRLEVTWDDTK 2078
+ + ++ + LK + +++ KD++ A V +++++ W++
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDIS-AKAVQDKLDQMVFIWENIH 3731
Query: 2079 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTT---IKDQED-------L 2128
L+ E + + +++L ++ ++ S ++ + T I+D ED +
Sbjct: 3732 TLVEEREAKLLDVMELAEKFW---------CDHMSLIVTIKDTQDFIRDLEDPGIDPSVV 3782
Query: 2129 KWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL----KKIHSSDFSLVKTDMESTVDK 2184
K ET + +++ Q++LD + G L++ K I + + +S
Sbjct: 3783 KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKA 3842
Query: 2185 WLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELL 2244
W D +KLEE M + ++ D + + D ++ + + M+ ++L+ + E L
Sbjct: 3843 WKDRIDKLEEAM---QAAVQYQDGLQAVFDWVD-IAGGKLASMSPIGTDLETVKQQIEEL 3898
Query: 2245 KEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQ-KL--EHAKEITEV 2301
K+F+SE + + +E L+ + + L K + D ++ LM+ KL + +E
Sbjct: 3899 KQFKSEAYQQQIEMERLN---HQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIIN 3955
Query: 2302 AKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN----CAQNETCE-ALKKVKDIQKEL 2356
+ L+ Q + ++++ W T E L + E L K +Q ++
Sbjct: 3956 RQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4015
Query: 2357 QSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE- 2415
+ QS + + + N L E +L + L ++ + V + + + L +L
Sbjct: 4016 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4075
Query: 2416 -KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
K F +++ Q+W + S G + + +L+ + + + ++
Sbjct: 4076 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4135
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
Q+GQ + A K ++I + I E++++ + + K L++ + F + +
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDF 4195
Query: 2535 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2594
W+ + E+ N + + + HKV F E+ + RE + +L + G L +
Sbjct: 4196 INWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVNSHREQIIELDKTGTHL--K 4251
Query: 2595 GHGAGQEGRLCSQLLTSHQN----LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAI 2650
Q+ L LL S Q+ +++ E+ RS A + + EA + W++
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES 4311
Query: 2651 QDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQAL-RSSNKEGQRV 2709
+ L D ++ +L+Q ++ G + G ++S +
Sbjct: 4312 EKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLK 4371
Query: 2710 IQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQP 2769
+ L L++ W I SV Q+ LE + + + L W+ V+ ++
Sbjct: 4372 LDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPV 4431
Query: 2770 QPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYE-KTEDESFKDTAQEELKTQF 2828
+ L+D+ ++ E T ++ L +REL E +D S+ +EL T++
Sbjct: 4432 HGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRW 4491
Query: 2829 NDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2888
+ ++ K ++E ++ + VH +WL A++ L + D A + +
Sbjct: 4492 ETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLID 4551
Query: 2889 KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQ 2948
+ KE + E + L++ ++ V + + +RA ++E+ + +
Sbjct: 4552 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRA---RFEEVLAWAK 4608
Query: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008
+ L S +A G +A+ ++ LE A L+ WA+ T L K D+E++
Sbjct: 4609 QHQQRLASALA-------GLIAK-QELLEALLAWLQ-WAE--TTLTDK--DKEVIP---- 4651
Query: 3009 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEY 3054
QEI E++K+ + E F +++ V + K Y
Sbjct: 4652 -QEI-----------EEVKALIAEHQTFMEEMTRKQPDVDKVTKTY 4685
Score = 159 bits (401), Expect = 2e-37
Identities = 417/2207 (18%), Positives = 833/2207 (37%), Gaps = 317/2207 (14%)
Query: 6668 LNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727
L+ Q + L+D + + S SD+ ++ C ++ K R E +
Sbjct: 683 LSNLQSRFEDFLEDSQESQV-FSGSDITQLEKEVNVC-KQYYQELLKSAEREEQEESVYN 740
Query: 6728 RYQSESADLIHWLQSAKDRL----------------EFWTQQSVTVPQELEMVRDHLNAF 6771
Y SE ++ L++ +DRL F + + +ELE ++D L
Sbjct: 741 LYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTI 800
Query: 6772 LEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKL 6831
+E +Q++ SSV TLRSEL+ + + + +KL
Sbjct: 801 TNKCEEFFSQAAASSSV---------------PTLRSELNVVLQNMNQVYSMSSTYIDKL 845
Query: 6832 H--QLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDI 6889
L + + A+ ++ E + D++NI+N I K ++ ++
Sbjct: 846 KTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLIS---------TLKQWRSEV 896
Query: 6890 NCKQLTVDFVN---QSVLQISSQDVESKRSDKTDF---AEQLGAMNKSWQILQGLVTEKI 6943
+ K+ + Q IS + ++ + DF E+ + + WQ + + ++
Sbjct: 897 DEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRL 956
Query: 6944 QLLEGLLESWSEYENNVQCLKTWFETQE--KRLKQQHRIGDQASVQNALKDCQDLEDLIK 7001
+ LEG+ +S Y + L W + E +R Q+++ + ++ L + L I+
Sbjct: 957 RDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE 1016
Query: 7002 AKEKEVEKIEQNGLALIQNKKE-DVSSIVMSTLRELGQ-TWANLDHMVGQLKILLKSVLD 7059
K+ ++++ ++ K+ ++ ++ + + Q + M ++++ +D
Sbjct: 1017 MKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMD 1076
Query: 7060 QWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEA-----------VQVQVDNLQNLQDD 7108
+ + + Y+ A SL R SLE +Q V N+ D
Sbjct: 1077 LRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKD 1136
Query: 7109 LEKQER---SLQKFGSITNQLLKECHPPVTET-------------------LTNTLKEVN 7146
EK + S QK S KE +T L +K +
Sbjct: 1137 AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQ 1196
Query: 7147 MRWNNLLEEIAEQLQSS----------KALLQLWQRYKDYSKQCASTVQQQEDR------ 7190
+N L E +QLQ S K + + Q YK+ + + Q E+R
Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQE 1256
Query: 7191 -------TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
T EL K + ++ ++ Q ++ VK++ FL E GE+L Q+
Sbjct: 1257 AFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEV------VKNTENFLKENGEKLSQED 1310
Query: 7244 DASAASAIQSDQLSLSQHLCALEQA----------LCKQQTSLQAGVLDYETFAKSLEAL 7293
A + ++ Q EQ+ K++T A V E +E L
Sbjct: 1311 KALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENL 1370
Query: 7294 EAWIVEAEEILQGQDPSHSS-----------------------------------DLSTI 7318
W+ ++ + H + T
Sbjct: 1371 LDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTT 1430
Query: 7319 QERM----EELKGQMLKFSSMAPDLD--------RLNELGYRLPLNDKEI--KRMQNLNR 7364
QE + +++K Q K S + L + G L +KE K M+ L
Sbjct: 1431 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKV 1490
Query: 7365 HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISG--NYQHLLEQ 7422
H+ +++ ++ S + + F + +L Q+EQ+L +G + L+ +
Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTK 1550
Query: 7423 QRAHELFQAEMFSRQQILHSIIIDGQRLLEQ---------GQVDD---RDEFNLKLTLLS 7470
+ + F ++ S + L I I G R+LE G+VD E KL +
Sbjct: 1551 LKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHAT 1610
Query: 7471 NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQAR 7530
++++ + + + + ++Q Y + + L L L S PI +
Sbjct: 1611 DRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHL-SEPIAVDPKN 1669
Query: 7531 TLFDEVQFKEKVFLRQQ-GSYILTVEAGK---QLLLSADSG---AEAALQAELAEIQEKW 7583
+ Q +E L+ Q S + VE K ++LL A A+ +Q L +I ++
Sbjct: 1670 L---QRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRY 1726
Query: 7584 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQS--LPDHHEELHAEQM 7641
+ S + E+ +KL L + G+ + L+ + + L + +P + L
Sbjct: 1727 EDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQDIIS 1786
Query: 7642 RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH---QLS 7698
+ LE + + ++ S L +++ L ++ E H +
Sbjct: 1787 KNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETL 1846
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIA 7758
+ +++ ++ + SEK + E TQ ++V G + E L + QE +
Sbjct: 1847 AKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTE-----LSQYMQESTSEF 1901
Query: 7759 QENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ- 7817
E+K L+ + L + S S+ L K N+ + ++ +K+ KE + + Q
Sbjct: 1902 LEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEM-EDTIKEKKEAVTSCQE 1960
Query: 7818 QLDKN---MSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQR-------DIEK 7867
QLD + SL++W+ ++ PIV S +E++ + L + ++LQ +I+K
Sbjct: 1961 QLDAFQVLVKSLKSWIKETTKKV--PIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2018
Query: 7868 HSTGVASVLNLCEVLLHDCDACA---------------TDAE-------CDSIQQATRNL 7905
+ S+ NL + A A T+ E SI++ ++
Sbjct: 2019 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2078
Query: 7906 DRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA-FPSSSGVIYTVA 7964
+ ++ + ++ ++ QK ++ S WL+ +TA + + T A
Sbjct: 2079 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEA 2138
Query: 7965 -KEELKKFEAFQRQVHECLTQLELINKQYRRLARENR-TDSACSLKQMVHEGNQRWDNLQ 8022
K ++++ ++F+ ++ + + +++ + + L EN T A KQM+ E + +W L
Sbjct: 2139 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2198
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECD--VQAKIKQLKA 8080
+ ++L+ +F+T + WL E +L ++ + S + + +Q++
Sbjct: 2199 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2258
Query: 8081 FQQEISLNHNKIEQIIAQGEQLIEK--SEPLDAAIIEEELDELRRYCQEVFGRVERYHKK 8138
QE + + EQ+ A G+ ++ + +P I++E+L + + + G++
Sbjct: 2259 LLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDW 2318
Query: 8139 LIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSER 8198
+ + + ++ R L S LSDL S+ ++ + + N L AQ ++ E
Sbjct: 2319 IDQAIVKSTQYQSLLRSL----SDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEI 2374
Query: 8199 SGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEG--QDDKDFYLRGAVGLSDV 8256
V E DLS ++ +A S EG + KD
Sbjct: 2375 QQEKKQIKVAQALCE-----DLSALVKEEYLKAELSRQLEGILKSFKD------------ 2417
Query: 8257 MIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALD---DSRFQIQQTENIIRSKTP 8313
+ + E +V+ ++A A Q +Q+ + D++ + Q + I +K
Sbjct: 2418 -VEQKAENHVQHLQSAC--------ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLD 2468
Query: 8314 TGPELDTSYKGYMKLLGECSSSID-SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR 8372
L +K + K L S + ++ E+ L + + S + L +T
Sbjct: 2469 VLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKT-----N 2523
Query: 8373 WELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIEL 8432
W+ Q +E ++K++L+K ++ + ++W W+ + LE+ ++ D E
Sbjct: 2524 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEE---IKFCLDPAEGEN 2580
Query: 8433 QIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEE 8492
I KLK LQK +D ++ +N + + + D + + D V L
Sbjct: 2581 SIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHS 2640
Query: 8493 WRGLLQDALMQCQGFHEMS----HGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLM 8548
+ L++ + + F E+S L E +D + SN +LQ K L
Sbjct: 2641 KKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQ 2700
Query: 8549 QIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKEL 8608
+KH++ L QD+ + +++GT + +V I L ++V L
Sbjct: 2701 ALKHQV---DLAKRLAQDLVVE-ASDSKGTS--DVLLQVETIAQEHSTLSQQVDEKCSFL 2754
Query: 8609 E-KLLDVSSSQQDLSSWSSA-----DELDTSGSVSPTSGRSTPNRQK 8649
E KL + Q + S DELD+ V GR QK
Sbjct: 2755 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPV----GRDAETLQK 2797
Score = 93.6 bits (231), Expect = 8e-18
Identities = 417/2180 (19%), Positives = 828/2180 (37%), Gaps = 378/2180 (17%)
Query: 6735 DLIHW---LQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLST 6791
DL++W +Q DR E W +V LE ++ A EF +SSLK + +S
Sbjct: 284 DLLNWVDEMQVQLDRTE-WGSDLPSVESHLENHKNVHRAIEEF------ESSLKEAKISE 336
Query: 6792 GNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSW 6851
LK T +L R++SQ+ LL N QE+ H + SR A +E++ W
Sbjct: 337 IQMTAPLK----LTYAEKLHRLESQYAKLL-NTSRNQER-HLDTLHNFVSR-ATNELI-W 388
Query: 6852 ISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6911
++ +K+E+ + + + + + + K + ++ + + +SV +I+ Q +
Sbjct: 389 LN------EKEEEEV--AYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLL 440
Query: 6912 ESKRSDKTDFAEQLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQ 6970
+ AM W ILQ + + E ++ E+ N+ + +
Sbjct: 441 LENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT--AYFEFFNDAKEATDYLRNL 498
Query: 6971 EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ--NGLALIQNKKEDVSSI 7028
+ +++++ +S+ LEDL++ +E E++ Q + +A + K + + +
Sbjct: 499 KDAIQRKYSCDRSSSIHK-------LEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQL 551
Query: 7029 VMSTLRELGQTWANLDHMVGQLKILLKSVLDQW-----SSHKVAFDKINSYLMEARYSLS 7083
+T + + +I + D +SH+ + I+ EA
Sbjct: 552 KPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSV 611
Query: 7084 RFRLLTGSLEAVQV------QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTET 7137
F + + EAV + Q N+ L + +S+ + + N++ + V
Sbjct: 612 CFTVPPPNKEAVDLANRIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASI 671
Query: 7138 LT-------NTLKEVNMRWNNLLEEIAE-QLQSSKALLQLW-------QRYKDYSKQCAS 7182
T L + R+ + LE+ E Q+ S + QL Q Y++ K
Sbjct: 672 KTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAER 731
Query: 7183 TVQQQ--------------------EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGL 7222
Q++ EDR ++ +D + V I + L K L
Sbjct: 732 EEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFR-ITEQEKLKKEL 790
Query: 7223 GTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLD 7282
+KD L + E+ Q A+A+S++ + + L+ L + Q T + +
Sbjct: 791 ERLKDDLGTITNKCEEFFSQ--AAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDK-LKT 847
Query: 7283 YETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7336
K+ +A EA + + EE + + + +ST+++ E+ + F ++
Sbjct: 848 VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907
Query: 7337 PDLDRLNELGYRLPLNDKEI--------KRMQNLNRHWSLISSQTTERFSKLQSF---LL 7385
+L + + + KE ++ L W + Q R L+ L
Sbjct: 908 DELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLK 967
Query: 7386 QHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIII 7445
++ + W++ + T++K+ N + L Q ++ +E+ +Q S +
Sbjct: 968 YYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMKQ----SKMD 1023
Query: 7446 DGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLR 7505
+ Q+ EQ +D +T R ++DSQ + + R M
Sbjct: 1024 ECQKYAEQYSATVKDYELQTMTY---------------RAMVDSQQKSPVKRRRMQSSAD 1068
Query: 7506 KWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSAD 7565
+ E L V + Q + D ++ E+
Sbjct: 1069 LIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEE------------------------ 1104
Query: 7566 SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD----SLEKLRTF 7621
E +L+ E E EK K L++ ++ LKD EK K S E++ T
Sbjct: 1105 --EEKSLEEEKKEHVEKAKE----LQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTK 1158
Query: 7622 KKKLSQSLPDHHEEL--HAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISIL 7679
K++LS++L L H ++M +E Q+ L+++ + S
Sbjct: 1159 KEQLSEALQTIQLFLAKHGDKMTDEERNELE-------KQVKTLQESYNLLFSES----- 1206
Query: 7680 NERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN---- 7735
L Q Q + + + + + ER E + EK + +C+ LTQ E+++ +
Sbjct: 1207 -----LKQLQESQTSGDVKVEEKIVAERQQE---YKEKLQGICDLLTQTENRLIGHQEAF 1258
Query: 7736 --GDILIE-----EMIEKLKKDYQEEIA----IAQENKIQLQQMGERLA---KASHESKA 7781
GD +E E+L+KD Q + + + L++ GE+L+ KA E K
Sbjct: 1259 MIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL 1318
Query: 7782 SEIEYKLGKVNDRWQH----LLDLIAARVKKLKETLVAVQQLDKN---MSSLRTWLAHIE 7834
+E + K ++N + + L ++ +K+ E + AV+QL+++ + +L WL++++
Sbjct: 1319 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLLDWLSNVD 1378
Query: 7835 --SELA----KPIVYD-----------SCNSEE------------------IQRKLNEQQ 7859
SE A K ++ S EE Q LN+Q
Sbjct: 1379 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQENLNQQY 1438
Query: 7860 EL-----QRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICA 7914
+ ++ I +H + + + +VLL + E + +Q+ + L + A
Sbjct: 1439 QKVKAQHEKIISQHQAVIIATQS-AQVLLEKQGQYLSPEEKEKLQKNMKELKVHYETALA 1497
Query: 7915 MSMERRLKIEETWRL-WQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEA 7973
S E+++K+ + + +KF DY+ FE WL+ SE+ + +LK+ ++
Sbjct: 1498 ES-EKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKS 1556
Query: 7974 FQRQVHECLTQLELINKQYRRLARE---------NRTDSACS---LKQMVHEGNQRWDNL 8021
F V L I R+ + D++ + +++ + R+ +L
Sbjct: 1557 FSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATDRFRSL 1616
Query: 8022 QKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE------CDVQAKI 8075
+ + LK + + + +E A +L L + T +H SE ++Q ++
Sbjct: 1617 YSKCNVLGNNLKDLVDKYQHYEDASCGLLAGL--QACEATASKHLSEPIAVDPKNLQRQL 1674
Query: 8076 KQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAA--IIEEELDELRRYCQEVFGRVE 8133
++ KA Q +IS +E++ E L++ L A I++ LD++ +++ V
Sbjct: 1675 EETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVN 1734
Query: 8134 RYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQP 8193
++KL ++ L R L ++D L ++ + +S L Q L+ + Q
Sbjct: 1735 ERNEKL-QITL--------TRSLSVQD--GLDEMLDWMGNVESSLKEQGQVPLNSTALQD 1783
Query: 8194 LRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 8253
+ S+ +I LE D ++ S + + K F +
Sbjct: 1784 IISK-----------NIMLEQD------------IAGRQSSINAMNEKVKKF-----MET 1815
Query: 8254 SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTP 8313
+D S +A +K S H +++ +L ++ ++ + + +KT
Sbjct: 1816 TDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQ 1875
Query: 8314 TGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLK-EEEESLPGFVNLHSTETQTAGVIDR 8372
E+D K +L S LEHK E SL ++ H + A V+++
Sbjct: 1876 ALTEVDVPGKDVTELSQYMQESTSEF--LEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 1933
Query: 8373 WELLQAQALSKELRMKQN-------LQKWQQFNSDLNSIWAWLGDTEEE----------- 8414
L + E +K+ ++ F + S+ +W+ +T ++
Sbjct: 1934 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 1993
Query: 8415 -----LEQLQRLELSTDIQTIELQIK-----KLKELQKAVDHRKAIILSIN----LCSPE 8460
LE ++L+ ++T E+Q L L AV I ++ + + E
Sbjct: 1994 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGE 2053
Query: 8461 FTQADSKE------SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGL 8514
T +++E ++ ++ ++ ++ + LL++ L L + Q E S +
Sbjct: 2054 GTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAM 2113
Query: 8515 LLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVN 8574
+ L+ +++ + + D E ++ +Q + EL ++ +V L+D +LL
Sbjct: 2114 MQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELL-- 2171
Query: 8575 AEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL-------LDVSSS--------QQ 8619
E D EA R K +L E+ +EL +L L+ SS+ +
Sbjct: 2172 EENPDTPEAP--------RWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEA 2223
Query: 8620 DLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSS 8679
L W EL S + P S PN T R + + + P
Sbjct: 2224 QLKQWLVEKELMVS-VLGPLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGI 2280
Query: 8680 LSEPGPGRSGRGFLFRVLRA 8699
LS PG S RG + L A
Sbjct: 2281 LSRPGEDPSLRGIVKEQLAA 2300
Score = 54.7 bits (130), Expect = 4e-06
Identities = 93/447 (20%), Positives = 181/447 (40%), Gaps = 79/447 (17%)
Query: 373 EHLIQPLHRDGKLSLDQALVK-QSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA 431
E ++Q L G+ SLD A + + + S+L +W + +KSL + L E+A
Sbjct: 4274 EKVVQRLVERGR-SLDDARKRAKQFHEAWSKLMEWLEESEKSLDSEL----------EIA 4322
Query: 432 LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVP------ 485
+ I+ +L QHK+ ++ A H +Y T + G +
Sbjct: 4323 ------------NDPDKIKTQLAQHKEFQKSLGAK----HSVYDTTNRTGRSLKEKTSLA 4366
Query: 486 ------PDQLEDMAERFHFVSSTS--------ELHLMKMEFLELKYRLLSLLVLAESKLK 531
D L ++ +++ + S E L +F + L+ L E +L
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426
Query: 532 SWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVM 591
+G + V L+ N+ +F K + + Q LK++A + +GS +++ V
Sbjct: 4427 EDQPVHGDIDLVMNLIDNHKAF---QKELGKRTSSVQALKRSARELI--EGSRDDSSWVK 4481
Query: 592 KFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEK------MLNQ 645
M E + +W + S ++ LE + + + + V +L WL +AE+ +L
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541
Query: 646 SENA-------KKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWR 698
E+A K+F + L + G+ ++ C +K + ++ R+
Sbjct: 4542 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601
Query: 699 ELFMEVKQYAQ--ADEMDRM--KKEYTDCVVTLSAFA-TEAHKKLSEPLEVSFMNVKLLI 753
E+ KQ+ Q A + + K+E + ++ +A T K E + VK LI
Sbjct: 4602 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4661
Query: 754 QD----LEDIEQRVPVMDAQYKIITKT 776
+ +E++ ++ P +D +TKT
Sbjct: 4662 AEHQTFMEEMTRKQPDVDK----VTKT 4684
Score = 33.9 bits (76), Expect = 7.3
Identities = 61/327 (18%), Positives = 134/327 (40%), Gaps = 36/327 (11%)
Query: 8266 VKLTENAIKNTSGDHSALESQI-----RQLGKALDDSRFQIQQTENIIRSKTPTGPELDT 8320
+++ + +K++ D + E +I + L +D+ + Q+ +TE S P+
Sbjct: 256 MQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTE--WGSDLPSVESHLE 313
Query: 8321 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 8380
++K + + E SS+ E K+ E + + P + A + R E A+
Sbjct: 314 NHKNVHRAIEEFESSLK-----EAKISEIQMTAP-------LKLTYAEKLHRLESQYAKL 361
Query: 8381 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLK-- 8438
L+ +++L F S + WL + EEE E++ D I + K
Sbjct: 362 LNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE-------EVAYDWSERNTNIARKKDY 414
Query: 8439 --ELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGL 8496
EL + +D ++ I S+ + + + ++ + M +W + L +
Sbjct: 415 HAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQH 474
Query: 8497 LQDALMQCQGFHEMSHG--LLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 8554
+++ + F++ L L++ +RK D + L+D ++ M+ K EL
Sbjct: 475 IKENTAYFEFFNDAKEATDYLRNLKDAIQRK---YSCDRSSSIHKLEDLVQESMEEKEEL 531
Query: 8555 LESQLRVASLQDMSCQLL-VNAEGTDC 8580
L+ + +A+L + ++ + +DC
Sbjct: 532 LQYKSTIANLMGKAKTIIQLKPRNSDC 558
Score = 33.5 bits (75), Expect = 9.5
Identities = 72/362 (19%), Positives = 139/362 (38%), Gaps = 66/362 (18%)
Query: 382 DGKLSLDQAL--VKQSWDRVTSRLFDWHIQLDKSL------PAPLGTIGAWLYRAEVALR 433
D L LD L ++ WD + + + +L+++L L + WLYR E L
Sbjct: 4367 DDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426
Query: 434 EEITVQQVHEETANTIQRKLEQHKDLLQNT---DAHKRAFHEIYRTRSVNGIPVPPDQLE 490
E+ V + N I K+L + T A KR+ E+ + V Q++
Sbjct: 4427 EDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV-QMQ 4485
Query: 491 DMAERFHFVSSTSELHLMKM--------EFLELKYRLLSLLVLAESKLKSWIIKYGRRES 542
+++ R+ V + S ++ EF + + LL L AE L+ + ++
Sbjct: 4486 ELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDA 4545
Query: 543 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMN----ETT 598
+ L+ + F +K+ E + + + + V+ + T
Sbjct: 4546 LRTLIDQHKEF----------------MKKLEEKRAELNKATTMGDTVLAICHPDSITTI 4589
Query: 599 AQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLP 658
W + +R+ EEV++ ++ +AS A L AK++ L
Sbjct: 4590 KHW------ITIIRARFEEVLAWAKQHQQRLASALAGL-----------IAKQELLEALL 4632
Query: 659 HWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 718
W+Q A L + E++ +++++ L+ + FME Q D +D++ K
Sbjct: 4633 AWLQW------AETTLTDKDKEVIPQEIEEVKALI--AEHQTFMEEMTRKQPD-VDKVTK 4683
Query: 719 EY 720
Y
Sbjct: 4684 TY 4685
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 328 bits (840), Expect = 2e-88
Identities = 681/3700 (18%), Positives = 1440/3700 (38%), Gaps = 508/3700 (13%)
Query: 4693 RQTEQRV---SLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK---- 4745
+Q EQ +L + + +Q+ E +C + + +++ Q + ++ L A +K +
Sbjct: 2036 QQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLK 2095
Query: 4746 -MYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGET 4804
+ + V+K + +E+ L P R ++ + + + L
Sbjct: 2096 DLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVA 2155
Query: 4805 VTECESRMVQSIDFQTEMSRS--------------LDWLRRVKA-------------ELS 4837
E E + ++ +TE S++ LDW+ V + +LS
Sbjct: 2156 QKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLS 2215
Query: 4838 GPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHK---EKEKFTKAKELISADLE- 4893
G L+ D + + E++ +M A + +++ F A + A L+
Sbjct: 2216 G-ASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQ 2274
Query: 4894 --HSLA---------ELSELDGDIQEALRTRQATLTEIYS---QCQRYYQVFQAANDWLE 4939
H+L +L EL +L +A L ++ + + Q++ Q + WLE
Sbjct: 2275 HGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLE 2334
Query: 4940 DAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN------------LEELHSLVAT 4987
+++ L+ G +L FS + H L+ +S
Sbjct: 2335 RSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEG 2394
Query: 4988 LDP-----LIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREE- 5041
+P L+K K D ++ +L + R+ G+ +++L Q+H +Q + +
Sbjct: 2395 KEPSEIGNLVKDKLK-DATERYTALHSKCTRL----GSHLNML---LGQYHQFQNSADSL 2446
Query: 5042 ----------VIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5091
V +L++DT + +++ + +E+L+EH+ V + I+ +
Sbjct: 2447 QAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI 2506
Query: 5092 EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKK 5151
E + + + + + + LS + + ++ +L+ A+ + ++
Sbjct: 2507 EGEPAPDHRHVQETTDSILSHFQSLSYS--------LAERSSLLQKAIAQSQSVQESLES 2558
Query: 5152 ATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDG 5211
+ I +++ L G S + L + ++ +Q+S+L R+ ++
Sbjct: 2559 LLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETA 2618
Query: 5212 AAPTPGEEPPLMQEITA-MQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5270
+ T + E++ + CL QEK + KL+ Q EM E ++ +++
Sbjct: 2619 DSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQA----EMFEHLSGKLQQFMEN 2674
Query: 5271 TKEYLGN---PTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSL 5327
L + P +I +++Q L E + ++N++ + L +ELS
Sbjct: 2675 KSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEH------------LVTELSS 2722
Query: 5328 QLAEVALDL-----------KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTK 5376
ALDL K ++Q +KE E+ ++ QE + +KL + L +
Sbjct: 2723 --CGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKE 2780
Query: 5377 LKAK---TDNVVQAKTDQKVL-------------GEELDGCNSKLMELDAAVQKFL--EQ 5418
+ T+ + AK +K + G ++ N K L+ + + +
Sbjct: 2781 TEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDS 2840
Query: 5419 NGQLGKPL---AKKIGKLTELHQ-QTIRQAENRLSKLN----QAASHLEEYNEMLELILK 5470
G+ G L +G + H + + + + +S +N + L E E L+ IL
Sbjct: 2841 QGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILN 2900
Query: 5471 WIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEK 5530
+E+ A+ + W LE +E+ ++AM+ + T E
Sbjct: 2901 RMEEVHKEANSVLQW----------------LESKEEVLKSMDAMSSPTKTETVKAQAES 2944
Query: 5531 MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVG 5590
+AEL + + ++ Q +K L L + ++ E KK+Q L T V
Sbjct: 2945 NKAFLAELEQNSPKI-QKVKEALAGLLVTYPNSQEAE-NWKKIQEELNSRWERATEVTVA 3002
Query: 5591 RL-SLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEAS 5649
R L+E SH + L+P + +L V+ L + L Q++
Sbjct: 3003 RQRQLEESASHLACFQAAESQLRPWLMEKELMMG-------VLGPLSIDPNMLNAQKQQ- 3054
Query: 5650 RLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQ-ELQAQIS 5708
+Q + ++E Q+ + L + +G D ++TS +Q ELQ+
Sbjct: 3055 ------------VQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQ 3102
Query: 5709 RHEELAQKIKG--------------YQEQIASLNSKCKMLTMKAKHATMLLTVTE-VEGL 5753
+ EL K+ YQE + L+ K + + + + + T E V+
Sbjct: 3103 KWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQ 3162
Query: 5754 AEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSP 5813
E T ++ +L + TL ++ GE+ E+
Sbjct: 3163 LEETSEIRSDL--------EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLE------ 3208
Query: 5814 VANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSW 5873
+V + + L+A+R+ ++ + +++Q+F + + D R+W
Sbjct: 3209 ------TVALPLQGLEDLAADRIN----RLQAALASTQQFQQ----------MFDELRTW 3248
Query: 5874 ETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQ 5933
L+ +Q Q IS K+E ++ +L E+ E +S ++
Sbjct: 3249 -----------------LDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYE 3291
Query: 5934 ALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGK 5993
++ E E L+ + E+ LQ+ L L + K + +
Sbjct: 3292 VIVAE---------------GESLLLSVPPGE--EKRTLQNQLVELKNHWEELSKKTADR 3334
Query: 5994 RQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLM 6053
+ L++ + Q Q+Y+ ++L W+ KA + + L +P+ +E+ L+
Sbjct: 3335 QSRLKDCM----------QKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLL 3383
Query: 6054 DCQNMLVEIEQKVVALSEL----------SVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6103
+ ML E+E++ L L S +E+ + + KA + + +L+ G
Sbjct: 3384 RSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTG 3443
Query: 6104 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQ 6163
SL E+ + L + Q + + ++ E + L + G Q + + L+ Q
Sbjct: 3444 SLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQ--------ACSNKNLEKLRAQ 3495
Query: 6164 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGE---KPDVLSQE-LGMEGEKSS 6219
+E+ Q L Q LR+ E A DA + + +V QE L ++ +S
Sbjct: 3496 QEVLQALEPQVDYLRNFTQGLVE------DAPDGSDASQLLHQAEVAQQEFLEVKQRVNS 3549
Query: 6220 AEDQMRMKWESLHQEFSTKQKLLQNVLEQEQE--------------QVLYSRPNRLLSGV 6265
M K E + Q +++ + + + E Q L+ +
Sbjct: 3550 GCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKI 3609
Query: 6266 PLYKGDVPTQDKSAVTSL-------LDGLNQAFEEVSSQSGG------AKRQSIHLEQKL 6312
+ K D+ + L L GL + E ++ Q G A+++ + L
Sbjct: 3610 HVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGR 3669
Query: 6313 YDGVSATSTWLDDVEERLFVATALL-PEETETCLFNQEIL------AKDIKEMSEEMDKN 6365
+ L+D A AL TE + NQ++ + + + ++ +
Sbjct: 3670 VEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729
Query: 6366 KNLFSQAFPENGDNRDV--IEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLK 6423
L G + DV +E + + R + L+ V QR Q++E L FQ+ L+
Sbjct: 3730 NGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALE 3789
Query: 6424 VLFTSLADNKYIIL-QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDK---- 6478
L + LAD + +I QK + + V QI+ + + L + A + L+ G +
Sbjct: 3790 PLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQS 3849
Query: 6479 --LQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQE 6536
L + +L L+ + EL+ +R+ L L L Q+ + ++D L ++
Sbjct: 3850 AELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEK 3909
Query: 6537 KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFR---KIISFAVQKETQFHT 6593
K+A + + + + IQQ + +HK + +E+H + + S E +
Sbjct: 3910 KLANSEPVGTQTAK-IQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLS 3968
Query: 6594 E----LMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEE 6649
E L A+ S + R ++ L+ L ED+ E+ L VE + SV + +
Sbjct: 3969 EKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF 4028
Query: 6650 NEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWL 6706
+D L + + L + + + Q + +G+ LL + + ++ +L+ + +
Sbjct: 4029 KQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 4088
Query: 6707 SNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRD 6766
T SK L LE + T++QS +L WL+ ++ L QS T Q
Sbjct: 4089 DITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQ------- 4141
Query: 6767 HLNAFLEFSKEVDAQSSLKSSVLSTGNQLLR-LKKVDTATLRSELSRIDSQWTDLLTNIP 6825
+ F + KE+ + VL T N++ R L ++ R L ++ S D
Sbjct: 4142 -IPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS---DANEQYK 4197
Query: 6826 AVQEKLHQLQMDKLPS--------RHAISEVMSWIS------LMENVIQKDEDNIKNSIG 6871
V + + Q ++D++ + A ++W++ + I+ ++D
Sbjct: 4198 LVSDTIGQ-RVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQ-- 4254
Query: 6872 YKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKS 6931
LQ K F IDI + ++D + +I E + KT E+ ++ +
Sbjct: 4255 -------LQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQ---KTVLQEKTESLIQQ 4304
Query: 6932 WQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIG-DQASVQNAL 6990
++ + L +E+ LE +++ + L W E + Q D ++
Sbjct: 4305 YEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQ 4364
Query: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050
++ + L + I + ++K+ + G L + E+ +V ++ +A + V Q
Sbjct: 4365 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEE-GEMVEEKYQKAENMYAQIKEEVRQR 4423
Query: 7051 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFR---LLTGSLEAVQVQVDNLQNLQD 7107
+ L + Q + DKI L SR R L+ ++ ++ + + ++
Sbjct: 4424 ALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATV 4483
Query: 7108 DLEKQERSLQKFGSITNQLLKECHPP----VTETLTNTLKEVNMRWNNLLEEIAEQLQSS 7163
+LEK + S + +L+ + + + L ++ W ++ E+
Sbjct: 4484 ELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKF 4543
Query: 7164 KALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLG 7223
+L+L +++ +T++ +D ++L + I +V + + +
Sbjct: 4544 LDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQV----EAAETIKEETD 4599
Query: 7224 TVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE-------QALCKQQTSL 7276
+ + L F+ LG L + A + + S+ + A E + L K + ++
Sbjct: 4600 GLHEELEFIRILGADL---IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAM 4656
Query: 7277 QAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMA 7336
QA V +T + L+ +++ + P +DL+T+++++ E+K ++
Sbjct: 4657 QAAVQYQDTLQAMFDWLDNTVIKLCTM-----PPVGTDLNTVKDQLNEMKEFKVEVYQQQ 4711
Query: 7337 PDLDRLNELGYRL-----PLNDKEIKR--MQNLNRHWSLISSQTTERFSKLQSFLLQHQT 7389
++++LN G + D++I R + L W + + R KL+ LL
Sbjct: 4712 IEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQ 4771
Query: 7390 FLEKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDG 7447
F E M +L TE+ L + ISG+ + + + H + + ++ + Q + ++ G
Sbjct: 4772 FQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG 4831
Query: 7448 QRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKW 7507
LLE DD +L ++ W+ V+++ ++R + S ++Q Q + ++ +
Sbjct: 4832 NELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHS---EIEDF 4888
Query: 7508 LVEVSYLPMSGLGSVP---IPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSA 7564
L+E++ + S P +P L ++ ++ +++ +Y ++ G+ +LLS
Sbjct: 4889 LLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEE-TYNQLLDKGRLMLLSR 4947
Query: 7565 D-SGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKK 7623
D SG+ + + +A +++KW S ++EE+K KL L + + + + + L ++
Sbjct: 4948 DDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQ 5007
Query: 7624 KLSQSLPDHH--EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE 7681
L+ + P + ++ K N V + D + +L + L D+ ++
Sbjct: 5008 SLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKN 5067
Query: 7682 RVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE 7741
+ +Q +WE++ + R + + + F E K+L +WL ES + +I +
Sbjct: 5068 LLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISND 5127
Query: 7742 EMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESK-----ASEIEYKLGKVNDRWQ 7796
KL+ +E K + R +A E + +++ LG+V D+W
Sbjct: 5128 PDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWD 5187
Query: 7797 HLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRK 7854
+ R KL+E L+ Q + +L WL +E +LA+ P+ D + +
Sbjct: 5188 TVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL---DLVMNL 5244
Query: 7855 LNEQQELQRDIEKHSTGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNI 7912
++ + Q+++ K TG VL E++ + D + ++ + L RW +
Sbjct: 5245 MDAHKVFQKELGKR-TGTVQVLKRSGRELIENSRD------DTTWVKGQLQELSTRWDTV 5297
Query: 7913 CAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT----AAFPSSSGVIYTVA---K 7965
C +S+ ++ ++E+ + + F D +WL +E+T A P + + ++ K
Sbjct: 5298 CKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK 5357
Query: 7966 EELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRV 8025
E +KK E + V+ + E+I D ++K + R++ +
Sbjct: 5358 EFMKKVEEKRVDVNSAVAMGEVI-------LAVCHPDCITTIKHWITIIRARFEEVLTWA 5410
Query: 8026 TSILRRLKHFIGQREEFETARDSILVWLTEMDLQL---------TNIEHFSECDVQAKIK 8076
+RL+ + + + +L W+ + L NI+ V+A I
Sbjct: 5411 KQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDR-----VKALIA 5465
Query: 8077 QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEE 8116
+ + F +E++ ++++ ++ + EP A IE+
Sbjct: 5466 EHQTFMEEMTRKQPDVDRVTKTYKR--KNIEPTHAPFIEK 5503
Score = 322 bits (826), Expect = 8e-87
Identities = 657/3712 (17%), Positives = 1459/3712 (39%), Gaps = 474/3712 (12%)
Query: 2267 DLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTW 2326
D K L K+L + D +L H + E+ K + + Q TQ+E + D+ W
Sbjct: 1887 DAKNLQKSLSSVSDTW------NSRLLHFQNAVEIEKTKVLN---QHTQLEGRLQDLRAW 1937
Query: 2327 FTKVEESLMNCAQNETCEA------LKKVKDIQKELQSQQSN-----------ISSTQEN 2369
L + N + L++ +D+++ + +++ IS ++
Sbjct: 1938 VGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQD 1997
Query: 2370 LNSLCRKYHSAELESLGRAMTGLIKKHEA-VSQLCSKTQASLQESLEKHFS-------ES 2421
L+ + L L R+ ++++ A V L Q QE+L K +
Sbjct: 1998 LSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQ 2057
Query: 2422 MQEFQEWFLGAKAAAKESSDRTG--DSKVLEAKLHDLQNILDSVSDGQSKLDAVT----- 2474
+++ W A+ A RT D L+ DL+++ D + + + V
Sbjct: 2058 LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEG 2117
Query: 2475 --QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHR 2532
+E QT LS + +++++E++ +A E+++A ++ ++ L++ + E +
Sbjct: 2118 FMEENQT---KLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKS 2174
Query: 2533 KLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLS----QRG 2588
K + L E+K+ I + V V G+LL +++LS ++G
Sbjct: 2175 KA------------AKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKG 2222
Query: 2589 QLLSEEGH-GAGQE----GRLCSQLLTSHQNLLRMTKEKL---RSCQVALQEH------E 2634
L + +G+ G Q + C + HQ LL + + +S Q L +H E
Sbjct: 2223 ALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPE 2282
Query: 2635 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ-IQDIL--------------- 2678
+ Q + + LA +E+ L TL+ L + +QD
Sbjct: 2283 EQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELEN 2342
Query: 2679 -------------LMKGEGEVKLNMAIGKGEQA-----------LRSSNKEGQR------ 2708
L+K +G ++ KG+ + +S KEG+
Sbjct: 2343 MHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGN 2402
Query: 2709 VIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQ 2768
+++ +L+ E + + S S L ++ Q++ + + L+ WM++ + +E L
Sbjct: 2403 LVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLS 2462
Query: 2769 P----QPG-LKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELY-EKTEDESFKDTAQE 2822
PG L+E+ LQ L+E + L ++ E+ E D +
Sbjct: 2463 DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTD 2522
Query: 2823 ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSA 2882
+ + F + E+ +++ + +++ + ++ L S S
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGV 2582
Query: 2883 TQKKLS---KIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ 2939
Q+ L+ K+K+ I ++ + + E +TTA+ +Q A+ Q
Sbjct: 2583 IQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQ 2635
Query: 2940 WEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTD 2999
+ + Q E+ + ++ + F +L+Q +E S +L + G D
Sbjct: 2636 RFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLAS---------GNQPD 2686
Query: 3000 EEIVECWHKGQEILDALQKAEPRTEDLKSQLNEL--CRFSRDLSTYSGKVSGLIKEYNCL 3057
++I + + QE+ ++ + + L+ + EL C F+ DL + +V L K++ L
Sbjct: 2687 QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTEL 2746
Query: 3058 CLQASKGCQNKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQ 3115
+ ++ +Q FRK R FQ+WL + + + + E+ ++ ++
Sbjct: 2747 QKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPT-ETSMSAKELEKQIEHLK 2805
Query: 3116 EFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAK-------VTAAKEDWKNFHSN- 3167
L + + + + KG L L+ + A Q K V ++ +H+
Sbjct: 2806 SLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCK 2865
Query: 3168 ----------------------LHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHE 3205
LH+++ +L+ + +M++ A + WL E+++
Sbjct: 2866 DLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVL-- 2923
Query: 3206 SSNRLYDLPAK----RREQQKLQSVLEEIHCYEPQLNRLKEKAQQL---WEGQAASKSFR 3258
S P K + + + ++ L E+ P++ ++KE L + +++++
Sbjct: 2924 KSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWK 2983
Query: 3259 HRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTS 3318
+L+S++ + +T + +L+ + F +L+ W+ + M+ +
Sbjct: 2984 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 3043
Query: 3319 DKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT--IQQQLQSVKDM 3376
D ++L+++ +++ +L + + Q + + + +L + T +Q++LQS+
Sbjct: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQK 3103
Query: 3377 WASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN-------ESERQHAEL 3429
W L SQ++ A+ K T YQ+ ++ S + ++ L+ + E +L
Sbjct: 3104 WVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQL 3163
Query: 3430 RDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT---QLELQDLQERYRAIQER 3486
+ + + + L+ EV +L + + V + E Y+ + L+ + + +++
Sbjct: 3164 EETSEIRSDLEQLDHEVKEAQTLCDELSVL---IGEQYLKDELKKRLETVALPLQGLEDL 3220
Query: 3487 AKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQ 3546
A + + + + + Q++Q+ WL +Q + + + ++ L++ +E Q
Sbjct: 3221 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 3280
Query: 3547 VHCAEGQALLNSVLHTREDVIPSGIPQAEDRALES----LRQDWQAYQHRLSETRTQFNN 3602
+ ++ E ++ S P E R L++ L+ W+ + ++ +++ +
Sbjct: 3281 KSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKD 3340
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESH------- 3655
+ K + + + + W++ + K VT ++E R++ +L+E
Sbjct: 3341 CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLE 3400
Query: 3656 -VNSRMGCQATQLTSRYQALLLQ---VLEQIKFLEEEIQ----SLEESESSLSSYSDWYG 3707
+NS + + + + + + + EE+Q SLEE L + + +
Sbjct: 3401 ILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFK 3460
Query: 3708 STHKNFKNVATKIDKVDTV----MMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYL 3763
+ K + +++ D + K L+ L + ++ + R + V+
Sbjct: 3461 NIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDA 3520
Query: 3764 EEG-EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
+G +A +L + ++ E+ V + +E L +F + + + +A+ +
Sbjct: 3521 PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
Query: 3823 IL-------HVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV 3875
L + + ++ + + L+K L+ + + E + + E+ E L+L+
Sbjct: 3581 ELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEE-EGTLDLLG-- 3637
Query: 3876 TLKDKIDQLQSDYQDLCSIGKAMMEE---------------------------------I 3902
LK +++ L L GKA E+ +
Sbjct: 3638 -LKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWV 3696
Query: 3903 AGFEDRLNNLQMKGDTLIG-QCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLE 3961
G E + N Q+ + + D LQ KL+Q V+ QG S C Q LE
Sbjct: 3697 VGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ-VNGLGQGLIQSAGKDCDV-----QGLE 3750
Query: 3962 HELQKHVSRQDTLQQ---------------CQAWLSAVQP---------DLEPSPQPPLS 3997
H++++ +R +TL + C + A++P +L + +PP +
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810
Query: 3998 RAEAIK-QVKHFRALQ---EQARTYLDLL----------CSMCDLSNASVKTTAKDIQQT 4043
+ +K Q++ + LQ + + +D+L + D + + + + + T
Sbjct: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870
Query: 4044 E---------QTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQ------QLQNMKRR 4088
E + +E LV A+ + E I S L +++ ++Q R
Sbjct: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR 3930
Query: 4089 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWL 4148
H LE +I +N + V VK QS + + + V L++K +S + + + + D+
Sbjct: 3931 HKALEEDI-ENHATDVHQAVKIGQSLSSLTSPAEQGV--LSEKIDSLQAR-YSEIQDR-- 3984
Query: 4149 DLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALK 4208
CR++ L ++ L R + + V +L + + ++ D + +H +
Sbjct: 3985 -CCRKAALL----DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
Query: 4209 KLAL--ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQ 4266
LAL + RK ++ Q +++ ++ L++E+ ++ R+ + + ++
Sbjct: 4040 HLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALR 4099
Query: 4267 VSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAK 4326
+ QS ++EL W E + +A + QSP + + E+
Sbjct: 4100 TLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEH 4159
Query: 4327 QMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQ 4386
+++L ++ + + ++ + R+ + K +SDA +SD +GQR ++ A+ Q
Sbjct: 4160 RLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQ 4219
Query: 4387 FLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQG 4446
+ A + + + +RK+M I L D + Q++ K+ + +++ + L++
Sbjct: 4220 YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHR 4279
Query: 4447 RELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHW 4506
E+ E++K+ + K + L Y+++ S R LE+ V F E +++ W
Sbjct: 4280 SEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW 4339
Query: 4507 LKQ--ADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNE 4564
+++ A I P + +E +L Q + + + E E++ + L + G L LN
Sbjct: 4340 IEETRALIAQLPSPAIDHE--QLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ-LKELNP 4396
Query: 4565 VDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILAR---KEYASLIELTTQSLSELEA 4621
+ + EK + I + + + EA+ E+ IE ++L L +
Sbjct: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSS 4456
Query: 4622 QFLRMSKVPTDL-AVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ--- 4677
+ +P ++ + E +S L+++ EA+ ++ G RS G
Sbjct: 4457 RLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG-RSQGADKDLAA 4515
Query: 4678 ---PDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVN 4734
DK+ +V + +K + E+R D + EK + L ++K+ Q V+
Sbjct: 4516 KEIQDKLDQMVFFWEDIKARAEEREIKFLD---VLELAEKFWYDMAALLTTIKDTQDIVH 4572
Query: 4735 EETLPA------EEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQ 4788
+ P +++++ ++ L+ + I DL + R I
Sbjct: 4573 DLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSID 4632
Query: 4789 SWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRR--VKAELSGPVYLDLN- 4845
+ L E + + E M ++ +Q + DWL +K PV DLN
Sbjct: 4633 EMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNT 4692
Query: 4846 LQDIQEEIR--KIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISAD-LEHSLAELSEL 4902
++D E++ K++++Q++++ M L+H+ + KA + D + L EL L
Sbjct: 4693 VKDQLNEMKEFKVEVYQQQIE-----MEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4747
Query: 4903 DGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQ----LAGNGLDVESAE 4958
++ E + RQ L ++ + WL +ELL ++G D + E
Sbjct: 4748 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISG---DPKVIE 4804
Query: 4959 ENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVA--SLELRSQRMSR 5016
L H H ++ + AT++ + K G E LE + LRS R+
Sbjct: 4805 VELAKH----------HVLKNDVLAHQATVETVNK-AGNELLESSAGDDASSLRS-RLEA 4852
Query: 5017 DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSS---------HEA 5067
+ +LQ+ + Q ++ ++ E L E + +++ S A
Sbjct: 4853 MNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETA 4912
Query: 5068 EEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDA-SKATLSRSMTTVWQRWTRLRA 5126
E+L H L S + + E L +K + + +D+ S + +S+ + Q+W + +
Sbjct: 4913 REQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSS 4972
Query: 5127 VAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTF 5186
++++ LE+A++ T F N +++ + + L +S +L+ +E H F
Sbjct: 4973 KMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVF 5032
Query: 5187 ----------VLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNM 5236
++EL+Q + L L Q+ +L + + ++Q R +
Sbjct: 5033 ANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL-------------IKNLLVSVQSRWEKV 5079
Query: 5237 QEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEA 5296
++ G+ + K + + W+++ + +L + +EI +++++ L++
Sbjct: 5080 VQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHL-DSELEISNDPDKIKLQLSKH 5138
Query: 5297 TNHRQNIE----------KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIR-DQIQDK 5345
++ + + KEK T+LP + S +L +++ + D + K
Sbjct: 5139 KEFQKTLGGKQPVYDTTIRTGRALKEK-----TLLPED-SQKLDNFLGEVRDKWDTVCGK 5192
Query: 5346 IKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAK----------TDNVVQAKTDQKVLG 5395
E + + S Q + L L K++ + D V+ KV
Sbjct: 5193 SVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQ 5252
Query: 5396 EELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAA 5455
+EL + L + ++ +E + + ++ +L+ + + ++ S+L QA
Sbjct: 5253 KELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQAL 5312
Query: 5456 SHLEEYNEMLELILKWIEKA-KVLAHGTIAWNSASQLREQYILHQTLLE--ESKEID-SE 5511
E + + + ++L+W+ +A + L + L+ H+ ++ E K +D +
Sbjct: 5313 KQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNS 5372
Query: 5512 LEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELK 5571
AM E + + C + + + EE+ K Q L+ A ++ L+
Sbjct: 5373 AVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLE 5432
Query: 5572 KLQAALEQAQATLTSPEVGRL-----SLKEQLSHRQHLLSEMESLKPKVQAV 5618
+L A ++ A+ TL + + +K ++ Q + EM +P V V
Sbjct: 5433 ELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRV 5484
Score = 313 bits (802), Expect = 5e-84
Identities = 717/4064 (17%), Positives = 1574/4064 (38%), Gaps = 528/4064 (12%)
Query: 2943 SVFQTQSCLEN---LVSQMALSE--QEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKN 2997
+VF Q CLE+ LVS ++L + + Q+ LE L + LL Q +LE +
Sbjct: 1796 NVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLC----QAKVLEREL 1851
Query: 2998 TDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCL 3057
D + QE+ Q + +++ +QL L +D +S + +N
Sbjct: 1852 KDLTTLV----SQELECVNQIIISQPQEVPAQL--LKALEKDAKNLQKSLSSVSDTWNSR 1905
Query: 3058 CLQASKGCQ-NKEQILQQ--RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKI 3114
L + K ++L Q + +D + W+ N + +
Sbjct: 1906 LLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLI--------------------L 1945
Query: 3115 QEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESA 3174
S SE LN+ L + E L + + KA+ + A D + F S Q S
Sbjct: 1946 NSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQ-----LDALAFDIQFFISEHAQDLSP 2000
Query: 3175 LENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYE 3234
+N ++ ++ QD L +T V L + EQ+ L L++
Sbjct: 2001 QQNRQM-LRLLNELQRSFQDILEQTAAQVDALQGHLQQM-----EQEALVKTLQK----- 2049
Query: 3235 PQLNRLKEKAQQL--WEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQF 3292
Q N ++ + L W GQA H+ AL + D I F
Sbjct: 2050 -QQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSF 2108
Query: 3293 SLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQ--EKEIQMKMIVTR 3350
+ +K+++ +M + L S T+ + L + EAL + +KE++ +
Sbjct: 2109 ATVVKDIEGFMEENQTKL-SPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 2167
Query: 3351 GESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSG 3410
+ ++ + + + ++++ ++ D S+ S+G + + L G G G
Sbjct: 2168 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGM-----EQLSGASLEKG 2222
Query: 3411 WMDSMEANLNESERQHAELRDKTTMLGKAK---LLNEE---VLSYSSLLETIEVKGAGMT 3464
+D+ + + + Q E DK + KA+ LL+++ +L+ S ++ G +T
Sbjct: 2223 ALDTTDGYMGVN--QAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLT 2280
Query: 3465 --EHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKL 3522
E + Q +L +L+E+Y +++ + + + L Q++ +D K FE WL + +++L
Sbjct: 2281 PEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL 2340
Query: 3523 DQY-----------SVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGI 3571
+ S+L+ E + +L+ GQ +L+ +E PS I
Sbjct: 2341 ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEI 2400
Query: 3572 PQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEE----- 3626
L+ + + A + + + N ++ + + + W++ E
Sbjct: 2401 GNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKL 2460
Query: 3627 -------------------KKWHEEVTAYRDEVEEVGARAQEIL--------DESHVNSR 3659
K+ EE+ ++ VE++ A++I+ D HV
Sbjct: 2461 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2520
Query: 3660 MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATK 3719
+ S +Q+L + E+ L++ I + + SL S G +N + +
Sbjct: 2521 ----TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG--KQ 2574
Query: 3720 IDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHM 3779
+ + + ++ + L T L +D+ + S L++ RE R ++ + A L+ ++ +
Sbjct: 2575 VSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVS 2634
Query: 3780 EQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKA 3839
++ ++L +++ +L+K L A+ F L Q++ +L +P ++
Sbjct: 2635 QRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHF-- 2692
Query: 3840 QLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMM 3899
++ +Q+ L E ++ +D L+ +L S G A+
Sbjct: 2693 ----FQQIQELNLEMEDQ--------------------QENLDTLEHLVTELSSCGFAL- 2727
Query: 3900 EEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQS 3959
++ +DR+ NL+ LQ +K+ KD+ S C ++
Sbjct: 2728 -DLCQHQDRVQNLRKD--------FTELQKTVKER-------EKDASS--CQEQLDEFRK 2769
Query: 3960 LEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQE----QA 4015
L QK WL + + P+ + +S E KQ++H ++L + +
Sbjct: 2770 LVRTFQK-------------WLKETEGSIPPT-ETSMSAKELEKQIEHLKSLLDDWASKG 2815
Query: 4016 RTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYL 4075
++ C L N ++ TA D Q +I + + G+ K L +E+ +
Sbjct: 2816 TLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL-TEIQCDM 2874
Query: 4076 QDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESP 4135
D +N+ + V L +Q S+ I+ ++ ++
Sbjct: 2875 SD----------------VNLKYEKLGGV------LHERQESLQAILNRMEEV------- 2905
Query: 4136 EHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARS 4195
HKE N + QWL+ +E++ ++ D E ++
Sbjct: 2906 -HKEANSVL-QWLE-----------SKEEVLKSMDAMSSPTKTET------------VKA 2940
Query: 4196 DAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWF 4255
AES L L++ + +Q+ K A+ L ++ + N + E K+ L RW
Sbjct: 2941 QAESNKAFLAELEQNSPKIQKVKEALAGL------LVTYPNSQEAENWKKIQEELNSRWE 2994
Query: 4256 QLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMD 4315
+ ++ + + + L Q+ +L W E++ + S P+M
Sbjct: 2995 RATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQ 3054
Query: 4316 HLAICSELEAKQMLLKSLIKDADRVMA---DLGLNERQVIQKALSDAQSHVNCLSDLVGQ 4372
+ E EA++ + L + A ++ D+ L+ QV ++ S Q V L+D +
Sbjct: 3055 VQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVE-LTDKLNS 3113
Query: 4373 RRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASL 4432
R +++A+ + TQ+ + + +++ +++ + I P+ V +Q++ ++ L
Sbjct: 3114 RSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDL 3173
Query: 4433 KTYQNEVTGLWAQGRELMKEVTEQE-KSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLV 4491
+ +EV EL + EQ K E+ +L+ + + + R+ L+ L
Sbjct: 3174 EQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALA 3233
Query: 4492 SRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTL 4551
S + F++ FD+ WL + + L +QL + + + ++ +
Sbjct: 3234 STQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVI 3293
Query: 4552 QRTGQTILPSLNEVDHSY-LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE 4610
G+++L S+ + L +L L + + D+ ++++ + ++Y +E
Sbjct: 3294 VAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVE 3353
Query: 4611 LTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFR 4670
+ + +A+ + + +E +L +A+L+EV ++ LN +
Sbjct: 3354 DLVPWIEDCKAKMSELRVTLDPVQLESSLLRS---KAMLNEVEKRRSLLEILNSAADILI 3410
Query: 4671 STGQPWQPDKMLHLVTLYHRLKRQTEQ---RVSLLEDTTSAYQEHEKMCQQLERQLKSVK 4727
++ + + + + TE+ + LE+ T +E ++ + +E++++ K
Sbjct: 3411 NSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAK 3470
Query: 4728 EE---------QSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPL 4778
+ Q+ N+ EKL+ + +L+ L+ T L + AP D
Sbjct: 3471 HQLEIFDALGSQACSNKNL----EKLRAQQEVLQALEPQVDYLRNFTQGLVEDAP--DGS 3524
Query: 4779 AYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSG 4838
+ HQ + Q E + + E+++ F + L + EL G
Sbjct: 3525 DASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDG 3584
Query: 4839 PVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAE 4898
+ + +Q +I +++ ++ + A + + + L L+ L
Sbjct: 3585 MGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEA 3644
Query: 4899 LSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN-GLDVESA 4957
L++ G + E + RQ L + + +Y+ + ND A+E L G +VE
Sbjct: 3645 LNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEII 3704
Query: 4958 EENLKSHMEFFSTE-DQFHSNLEELHSLVATLDPLIKPTGKE----DLEQKVASLELRSQ 5012
+ L F + D L++++ L LI+ GK+ LE + + R
Sbjct: 3705 NQQLADFKMFQKEQVDPLQMKLQQVNGLG---QGLIQSAGKDCDVQGLEHDMEEINARWN 3761
Query: 5013 RMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLS 5072
+++ ++ LQ +Q A E ++ + DTE+ ++ ++ + ++
Sbjct: 3762 TLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIAN-QKPPSAEYKVVKAQIQ 3820
Query: 5073 EHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQE 5132
E K L +++ + L+ + ++ ++ A + ++ + ++ RWT L + A ++
Sbjct: 3821 EQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQ 3880
Query: 5133 KILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5192
K LED + F+ + ++ + + KL S A++ + H ++E
Sbjct: 3881 KQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIEN 3940
Query: 5193 QQSALGMLRQ--QTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
+ + + Q+LS L +P E+ L ++I ++Q R +Q++ L+ Q
Sbjct: 3941 HATDVHQAVKIGQSLSSLT-----SPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQA 3995
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIE------IDAQLEELQILLTEATNHRQNIE 5304
L + + V W+ E ++ L + ++ + Q + L E N ++N++
Sbjct: 3996 LSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD 4055
Query: 5305 ---KMAEEQKEKYLGLYTILPSE----LSLQLAEVAL-DLKIRDQIQDKIKEVEQSKATS 5356
K + ++ G +L E + + A++ + K ++ + + ++T
Sbjct: 4056 QAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTY 4115
Query: 5357 QELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEE-------LDGCNSKLMELD 5409
+EL+ ++++ ++L T + + + Q + QK L +E LD N E+
Sbjct: 4116 EELTGWLREVEEELATSGGQ-SPTGEQIPQFQQRQKELKKEVMEHRLVLDTVN----EVS 4170
Query: 5410 AAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELIL 5469
A+ + + + G L K + E ++ R+ +++ A ++Y + + L
Sbjct: 4171 RALLELVPWRAREG--LDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAEL 4228
Query: 5470 KWIE--KAKVLAHGTIAWNSASQLREQYILHQTLLEESKEID--SELEAMTEKLQYLTSV 5525
W+ K K++A G I +L + Q ++++ ID ++M E + + +
Sbjct: 4229 AWVAETKRKLMALGPI------RLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEI 4282
Query: 5526 Y--CTEK----MSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQ 5579
+ C E+ + ++ L ++ E + + R L+ A + +F ++L +E+
Sbjct: 4283 FGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEE 4342
Query: 5580 AQAT---LTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A L SP + L++Q + L + KP + + L+ +
Sbjct: 4343 TRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEM- 4401
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQ---YEQEMKHLQQLIEGAHREIEDK 5693
+ + + ++++ Q+ + AV Q Q + +++ + + +E +
Sbjct: 4402 VEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMP 4461
Query: 5694 PVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGL 5753
P+ + + +++ IS ++ +++ Q +L + + L +++ A L E++
Sbjct: 4462 PLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDK 4521
Query: 5754 AEGT----EDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACR 5809
+ ED+ V+ + + + + +T + ++ SP
Sbjct: 4522 LDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP---- 4577
Query: 5810 SPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTS-----ASQEFYEPGL--EPSA 5862
++ I Q +AE ++ + +H + + G +P
Sbjct: 4578 ----------GIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEV 4627
Query: 5863 TAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPG 5922
+ ++ +WE L E+ L +A++ +YQD+LQ++ ++ +KL P G
Sbjct: 4628 RKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG 4687
Query: 5923 ---RSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVL 5979
+ + Q+ E + E+ Q E+ +L E ++ ++ D ++ ++ LT L
Sbjct: 4688 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQ-GELMLKKA--TDETDRDIIREPLTEL 4744
Query: 5980 AERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTAL 6039
+ K + ++ LE L AL +++ +EL SWL T+ LD
Sbjct: 4745 KHLWENLGEKIAHRQHKLEGAL----------LALGQFQHALEELMSWLTHTEELLDAQR 4794
Query: 6040 SPPKEPMDMEAQLMD---CQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAG 6096
+P +E +L +N ++ + V +++ N LLE A D+A L
Sbjct: 4795 PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAG----NELLESSA--GDDASSLRS 4848
Query: 6097 KLRRLKGSLLELQRALHDKQLNMQGTAQEKE--ESDVDLTATQSPGVQEWLAQARTT--W 6152
+L + + + +++ +Q T Q+ + S+++ + ++ L+ ++ T
Sbjct: 4849 RLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGL 4908
Query: 6153 TQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE-- 6210
+ + L EL +L ++ + +G +L+ + + + +L Q+
Sbjct: 4909 PETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWH 4968
Query: 6211 ---LGMEGEKSSAEDQMRM--KWESLHQEF--------------STKQKLLQNVLEQEQE 6251
ME KS E+ + + ++++ QEF S +L VL Q +E
Sbjct: 4969 VVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEE 5028
Query: 6252 QVLYSRP-----NRLL----SGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEV---SSQSG 6299
+++ ++++ +G L K QD + +LL + +E+V S + G
Sbjct: 5029 HKVFANEVNAHRDQIIELDQTGNQL-KFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERG 5087
Query: 6300 GAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALL--PEETETCLFNQEILAKDIKE 6357
+ + ++ ++ WL+D E L + P++ + L + K +
Sbjct: 5088 RSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGG 5147
Query: 6358 MSEEMD---------KNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQM 6408
D K K L PE+ D LG + V + +
Sbjct: 5148 KQPVYDTTIRTGRALKEKTL----LPEDSQKLD-------NFLGEVRDKWDTVCGKSVER 5196
Query: 6409 KERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFD-- 6466
+ +L++ L F +L D Y + +LA +QPV ++ + D K F
Sbjct: 5197 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAE--DQPVHGDLDLVMNLMDAHKVFQKE 5254
Query: 6467 ----AGIIELKRRGDKLQVEQPS------MQELSKLQDMYDELMMIIGSRRSGLNQNLTL 6516
G +++ +R + +E +L +L +D + + S++S L Q L
Sbjct: 5255 LGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQ 5314
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI----- 6571
+ + L + L ++ + + + E +Q L+D HKE+ + +E +
Sbjct: 5315 AEVFRDTVHMLLEWLSEAEQTLR-FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSA 5373
Query: 6572 ------------------------LTETLFRKIISFAVQKETQFHTELMAQASAVLKRAH 6607
+ F +++++A Q + + T L S ++ A
Sbjct: 5374 VAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETAL----SELVANAE 5429
Query: 6608 KRGVELEYILETWSH---LDEDQQELSRQLEVVESSIPSVGLVEENEDRL---IDRITLY 6661
L +I W+ + DQ+ + + ++ V++ I E R +DR+T
Sbjct: 5430 LLEELLAWI--QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKT 5487
Query: 6662 QHLKSSLNEYQPKLYQVLDDGKRLLIS--------ISCSDLES-QLNQLGECW------- 6705
K+ + P + + G++ L +S S+ ++ ++NQL W
Sbjct: 5488 YKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLA 5547
Query: 6706 LSNTNKMSKELHRLETILKHWTRYQSE--SADLIHWLQSAKDRL 6747
L K++ L RLE LK + + + + W+ K R+
Sbjct: 5548 LERQRKLNDALDRLEE-LKEFANFDFDVWRKKYMRWMNHKKSRV 5590
Score = 294 bits (753), Expect = 2e-78
Identities = 652/3548 (18%), Positives = 1383/3548 (38%), Gaps = 398/3548 (11%)
Query: 4826 LDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE-------VQSSLRIMNALSHKEK 4878
L LR ++ L+LNL ++Q+ + + ++ + E V L +N + +
Sbjct: 1814 LSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQP 1873
Query: 4879 EK----FTKAKELISADLEHSLAELSELDGD----IQEALRTRQATLTEIYSQCQRYYQV 4930
++ KA E + +L+ SL+ +S+ Q A+ + + ++Q + Q
Sbjct: 1874 QEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD 1933
Query: 4931 FQAANDWLEDAQELLQLAGNG--LDVESAEENLKSHMEFFSTEDQFHSNLE----ELHSL 4984
+A W+ + +L G+ +DV+S L+ + + + + L+ ++
Sbjct: 1934 LRA---WVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFF 1990
Query: 4985 VATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIE 5044
++ + P + + + L+ Q + + AQVD LQ H Q +E +++
Sbjct: 1991 ISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQG-----HLQQMEQEALVK 2045
Query: 5045 LMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGND 5104
+ + + S +AE L+ H+ + + + AL++ S L+ +D
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTT-----QQDLSALQKNQSDLKDLQDD 2100
Query: 5105 ASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLP 5164
+ R T V +D E +E+ N+ K + + L++KL
Sbjct: 2101 ------------IQNRATSFATVVKDIEGFMEE---------NQTKLSPRELTALREKLH 2139
Query: 5165 GSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQ 5224
+ + + E +T V + E +++ L+Q+T E+ +
Sbjct: 2140 QAKEQYEALQE--------ETRVAQKELEEAVTSALQQET-------------EKSKAAK 2178
Query: 5225 EITAMQ---DRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLG--NPT 5279
E+ + D L+ V ++G + L E + + + K + T Y+G
Sbjct: 2179 ELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQL-SGASLEKGALDTTDGYMGVNQAP 2237
Query: 5280 IEIDAQLEEL----QILLTEATN--------------HRQNIEKMAEEQKEKYLGLYTIL 5321
++D Q E + Q LL++ N H N+ ++ ++ LG L
Sbjct: 2238 EKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGE---L 2294
Query: 5322 PSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT 5381
+ S LA+ +LK +QD++++ Q +E +++ K+L + K +
Sbjct: 2295 KEQYSTSLAQSEAELKQVQTLQDELQKFLQDH---KEFESWLERSEKELEN-MHKGGSSP 2350
Query: 5382 DNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTI 5441
+ + Q E++ L + + QK L+ + K+ ++ L + +
Sbjct: 2351 ETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE--GKEPSEIGNLVKDKL 2408
Query: 5442 RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTL 5501
+ A R + L+ + L + L ++L + + A AW A + + +L T+
Sbjct: 2409 KDATERYTALHSKCTRLGSH---LNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTV 2465
Query: 5502 LEESKEIDSELEAMTEKLQ-----YLTSVYCTEKMSQQVAELG-------RETEELRQMI 5549
+ + +L A T++LQ + V +K+++ + E+ R +E I
Sbjct: 2466 ASDPGVLQEQL-ATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSI 2524
Query: 5550 KIRLQNL-----------QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS---LK 5595
Q+L Q A + + L+ L ++ + + L +V LS ++
Sbjct: 2525 LSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
Query: 5596 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5655
E L+ L ++ K ++A + + D + L +L E + R +
Sbjct: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQG---KLAEVSQRFEQLC 2641
Query: 5656 IQQC---NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEE 5712
+QQ + ++ + Q E +E LQQ +E R + +I QI +E
Sbjct: 2642 LQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQI---QE 2698
Query: 5713 LAQKIKGYQEQIASLN------SKC-----------KMLTMKAKHATMLLTVTEVEGLAE 5755
L +++ QE + +L S C ++ ++ + TV E E A
Sbjct: 2699 LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDAS 2758
Query: 5756 GTEDLDGELLPTPSAHPSVVMMTAGRC---HTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
++ E + T G T +S E E S + + +
Sbjct: 2759 SCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLV 2818
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS----QEFYEPGLEPSATAKLGD 5868
N + +++ ++A Q I PS +S ++ + D
Sbjct: 2819 EEINCKGTSLENLI--MEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSD 2876
Query: 5869 LQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSE-----SPEPGR 5923
+ +E L V+ E+Q +L L R ++ S+ +E+ E L SP
Sbjct: 2877 VNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTE 2936
Query: 5924 SPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 5983
+ ++Q ++A + E+ +I +++ +LA LV+ + +Q L ER
Sbjct: 2937 TVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERA 2996
Query: 5984 STIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPK 6043
+ + + QLEE A ++ +L WL+ + +
Sbjct: 2997 TEVTVARQR-----------QLEESASHLAC--FQAAESQLRPWLMEKELMMGVLGPLSI 3043
Query: 6044 EPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKG 6103
+P + AQ Q ML E E + +L+ + +L G Q+ +L+ +
Sbjct: 3044 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILT-GPGDVSLSTSQVQKELQSINQ 3102
Query: 6104 SLLELQRALHDK-----QLNMQGTAQEKEESDVD---LTATQSPGVQEWLAQARTTWTQQ 6155
+EL L+ + Q ++ T ++ D+ Q VQ ++ QQ
Sbjct: 3103 KWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQ 3162
Query: 6156 RQSSLQQQKELEQ---ELAEQKSLLRSVASR-GEEIL-------IQHSAAETSGD---AG 6201
+ + + + +LEQ E+ E ++L ++ GE+ L ++ A G A
Sbjct: 3163 LEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAA 3222
Query: 6202 EKPDVLSQELGMEGEKSSAEDQMRMKWESLHQE------FSTKQKLLQNVLEQEQE---- 6251
++ + L L + D++R + + S K + LQ+ L++ +E
Sbjct: 3223 DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKS 3282
Query: 6252 --------QVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKR 6303
+V+ + LL VP P ++K + + L L +EE+S ++ A R
Sbjct: 3283 LNQHSGSYEVIVAEGESLLLSVP------PGEEKRTLQNQLVELKNHWEELSKKT--ADR 3334
Query: 6304 QS-----IHLEQKLYDGVSATSTWLDDVEERLF-VATALLPEETETCLFNQEILAKDIKE 6357
QS + QK V W++D + ++ + L P + E+ L + + ++++
Sbjct: 3335 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK 3394
Query: 6358 MSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILN 6417
++ + + + D I D + + + + + ++E Q++
Sbjct: 3395 RRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLRE 3454
Query: 6418 FQNDLKVLFTSLADNKYII-------LQKLANVFEQPVAEQIEAIQQAE---DGLKEFDA 6467
FQ K + + K+ + Q +N + + Q E +Q E D L+ F
Sbjct: 3455 FQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQ 3514
Query: 6468 GIIELKRRGDK----LQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERA 6523
G++E G L + + QE +++ + +++ ++ G+ Q +
Sbjct: 3515 GLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQ 3574
Query: 6524 LQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES------HMILTETLF 6577
L DL D L+ G + D + S E+++ L+K +E+ HM+ E
Sbjct: 3575 LADLDDELD-GMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTL 3633
Query: 6578 RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYIL---ETWSHLDEDQQELSRQL 6634
+ +++E + L Q + +R R +LE L E + + + +
Sbjct: 3634 DLL---GLKRELE---ALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAA 3687
Query: 6635 EVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISIS---- 6690
E E+ VG E ++ + ++Q K ++ Q KL QV G+ L+ S
Sbjct: 3688 EEAEALQWVVGTEVEIINQQLADFKMFQ--KEQVDPLQMKLQQVNGLGQGLIQSAGKDCD 3745
Query: 6691 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6750
LE + ++ W + K+++ + +L+ L H ++Q L+ WL ++ +
Sbjct: 3746 VQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQ 3805
Query: 6751 TQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKV-DTATLRSE 6809
S E ++V+ + + +D + + + + G ++ + ++ D + +
Sbjct: 3806 KPPSA----EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3861
Query: 6810 LSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNS 6869
L ++S+WT+LL+ A Q++L + + + ++S+ E + E
Sbjct: 3862 LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEP----- 3916
Query: 6870 IGYKA--IHEYLQKYKGFKIDINCKQLTVDF---VNQSVLQISSQDVESKRSDKTDFAEQ 6924
+G + I + + ++K + DI V + QS+ ++S + S+K D
Sbjct: 3917 VGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID---- 3972
Query: 6925 LGAMNKSWQILQGLVTEKIQLLEGLLESWSEY-ENNVQCLKTWFETQEKRLKQQHRIGDQ 6983
++ + +Q K LL+ L + + E+ V+ L E ++K + Q
Sbjct: 3973 --SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 4030
Query: 6984 ASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANL 7043
+ D L + I ++K V++ +NG AL++ + ++ L + +A++
Sbjct: 4031 DVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADI 4090
Query: 7044 DHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQ 7103
+ L+ + + ++++ +L E L+ +G Q+ Q
Sbjct: 4091 TVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELAT----SGGQSPTGEQIPQFQ 4146
Query: 7104 NLQDDLEKQERS----LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQ 7159
Q +L+K+ L ++ LL+ E L + + N ++ + + I ++
Sbjct: 4147 QRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQR 4206
Query: 7160 LQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLL 7219
+ A +Q Q+Y+ Q A T L A + D+ +Q
Sbjct: 4207 VDEIDAAIQRSQQYE----QAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 4262
Query: 7220 KGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAG 7279
+ KDS+ L ++ + +Q SL Q A+ ++ L+
Sbjct: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 4322
Query: 7280 VLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDL 7339
+ F ++ E L WI E ++ Q PS + D ++++ EE++ + P +
Sbjct: 4323 QVLVNQFWETYEELSPWIEETRALI-AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 4381
Query: 7340 DRLNELGYRLP-LNDKE----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQT---FL 7391
D+L ++G +L LN +E ++ Q ++ I + +R L + Q F
Sbjct: 4382 DKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFH 4441
Query: 7392 EKCETWMEFLVQTEQKLAVE--ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQR 7449
+K E +E L +L + I + E ++ E+ Q ++ G+
Sbjct: 4442 DKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEE 4501
Query: 7450 LLEQGQVDDRD----EFNLKLTLLSNQWQGVIRRAQQRR----GIIDSQIRQWQRYREMA 7501
L+ + Q D+D E KL + W+ + RA++R +++ + W +
Sbjct: 4502 LIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALL 4561
Query: 7502 EKLRKWLVEVSYLPMSGLGSVPIPLQ--QARTLFDEVQ--FKEKVFLRQQGSYILTVEAG 7557
++ V L G+ I Q A T+ +E +E F+R G+
Sbjct: 4562 TTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGA-------- 4613
Query: 7558 KQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK---DWEKCEKGIADS 7614
L+ + + ++ + E+ W++ + +E+ +KL ++ ++ + + D
Sbjct: 4614 -DLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDW 4672
Query: 7615 LEK--------------LRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7660
L+ L T K +L++ + + E++ +Q+ ++L + +L
Sbjct: 4673 LDNTVIKLCTMPPVGTDLNTVKDQLNE-MKEFKVEVYQQQIEMEKLNHQ--------GEL 4723
Query: 7661 SLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKE 7720
L K T D I+ E + L+ WE L +++ R+ ++ L F +E
Sbjct: 4724 MLKKAT-----DETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEE 4778
Query: 7721 LCEWLTQMESKVSQ----NGDILIEEMIEKLKKDYQEEIAIAQENKIQ-LQQMGERLAKA 7775
L WLT E + +GD + E +E K + +A + ++ + + G L ++
Sbjct: 4779 LMSWLTHTEELLDAQRPISGDPKVIE-VELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837
Query: 7776 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7835
S AS + +L +N W+ +L R ++L+ TL Q + L +ES
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897
Query: 7836 ELA--KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDA 7893
+L+ KP E + +L+ EL ++ +L+ ++L D + +
Sbjct: 4898 QLSASKPT---GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4954
Query: 7894 ECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAF 7953
+ + Q+ L+++W + + ER+ K+EE L +F + F +WL +E++
Sbjct: 4955 KTE---QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNI 5011
Query: 7954 PSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHE 8013
S +I ++++ + F +V+ Q+ +++ +L ++ +K ++
Sbjct: 5012 ASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVS 5071
Query: 8014 GNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNIEHFSECD-V 8071
RW+ + +R R L + ++F A ++ WL + + L + +E ++ D +
Sbjct: 5072 VQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKI 5131
Query: 8072 QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS-EPLDAAIIEEELDELRRYCQEVFG 8130
+ ++ + K FQ+ + + I G L EK+ P D+ ++ L E+R V G
Sbjct: 5132 KLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCG 5191
Query: 8131 R-VERYHK 8137
+ VER HK
Sbjct: 5192 KSVERQHK 5199
Score = 273 bits (698), Expect = 5e-72
Identities = 677/3767 (17%), Positives = 1466/3767 (38%), Gaps = 444/3767 (11%)
Query: 5090 ALEEKASQLEKTGNDASKATLSRSM----------TTVWQRWTRLRAVAQDQEKILEDAV 5139
ALE+ A L+K+ + S SR + T V + T+L QD +
Sbjct: 1883 ALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQD--------L 1934
Query: 5140 DEWTGFNNKV---KKATEMID--------QLQDKLPGSSAEKASKAELLTLLEYHDTFVL 5188
W G N + K + ID Q + L AE+ KA+L L F+
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAER--KAQLDALAFDIQFFIS 1992
Query: 5189 ELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVK 5248
E Q S +Q L +L + ++ A+Q M+++ LVK
Sbjct: 1993 EHAQDLSP--QQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEA-----LVK 2045
Query: 5249 QELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAE 5308
K + Q+ + WV + + L Q Q L+ ++ +++ + +
Sbjct: 2046 TLQKQQNTCHQQLEDLCSWVGQAERALAGH------QGRTTQQDLSALQKNQSDLKDLQD 2099
Query: 5309 EQKEKYLGLYTILPS-ELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLA 5367
+ + + T++ E ++ + L + +++K+ + ++ QE +R QK
Sbjct: 2100 DIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKEL 2159
Query: 5368 KDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLA 5427
++ T + +Q +T++ +EL K+ A+ ++ G G L
Sbjct: 2160 EEAVT----------SALQQETEKSKAAKELAENKKKI----DALLDWVTSVGSSGGQLL 2205
Query: 5428 KKIGKLTELHQQTIRQAE----NRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTI 5483
+ + +L ++ + + +NQA L++ EM++ + E + +
Sbjct: 2206 TNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA--RHQELLSQQQNFIL 2263
Query: 5484 AWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETE 5543
A SA +Q+ H EE + + +L + E QY TS+ +E +QV L E
Sbjct: 2264 ATQSAQAFLDQHG-HNLTPEEQQMLQQKLGELKE--QYSTSLAQSEAELKQVQTLQDE-- 2318
Query: 5544 ELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQH 5603
LQ +D K+FE+ L++ + LE +SPE LK Q S +
Sbjct: 2319 ------------LQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSED 2366
Query: 5604 LLSEMESLKPKV---QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCN 5660
++S L+ Q V +++ + ++ L L+ E H+ +
Sbjct: 2367 VISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLG 2426
Query: 5661 I-MQAAVVQYEQYEQEMKHLQQLIEGAHREIED--KPVATSNIQELQAQISRHEELAQKI 5717
+ + QY Q++ LQ ++ +E S+ LQ Q++ ++L +++
Sbjct: 2427 SHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEEL 2486
Query: 5718 KGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAH-PSVVM 5776
+Q + L + + E+EG E + +H S+
Sbjct: 2487 AEHQVPVEKLQKVAR-------------DIMEIEGEPAPDHRHVQETTDSILSHFQSLSY 2533
Query: 5777 MTAGRCHTLLSPVTE-ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAER 5835
A R L + + +S +E S + S + +S++ + + +
Sbjct: 2534 SLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQ-NLEGKQVSSLSSGVIQEALATNMK 2592
Query: 5836 LQTDAAKIHPSTSASQEFYEPGLEP--SATA-----KLGDLQRSWETLKNVISEKQRTLY 5888
L+ D A+ S A++E +E S TA KL ++ + +E L EK+ +L
Sbjct: 2593 LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLK 2652
Query: 5889 EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINE 5948
+ L + + ++ +S K++ S G P+ + + E+ + ++ E
Sbjct: 2653 KLLPQAEMFEH----LSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQE 2708
Query: 5949 LQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQ 6008
+L E LV+E A L +R+ +R + ++ ++E+ D Q
Sbjct: 2709 NLDTL-EHLVTELSSCGFALDLCQHQ------DRVQNLRKDFTELQKTVKEREKDASSCQ 2761
Query: 6009 RQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPM----DMEAQLMDCQNMLVEIEQ 6064
Q L +R WL T+ ++ PP E ++E Q+ +++L +
Sbjct: 2762 EQ---LDEFRKLVRTFQKWLKETEGSI-----PPTETSMSAKELEKQIEHLKSLLDDWAS 2813
Query: 6065 KVVALSELSVHN---ENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHD-KQLNMQ 6120
K + E++ ENL++E T +++ G + GS + H K L
Sbjct: 2814 KGTLVEEINCKGTSLENLIME---ITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDL--- 2867
Query: 6121 GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQ-QKELEQELAEQKSLLRS 6179
T + + SDV+L + GV +RQ SLQ +E+ E S+L+
Sbjct: 2868 -TEIQCDMSDVNLKYEKLGGV-----------LHERQESLQAILNRMEEVHKEANSVLQW 2915
Query: 6180 VASRGEEILIQHSA------AETSGDAGEKPDVLSQELGMEGEK-------------SSA 6220
+ S+ EE+L A ET E EL K +
Sbjct: 2916 LESK-EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYP 2974
Query: 6221 EDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6280
Q W+ + +E +++ + V Q Q+ S + + +K +
Sbjct: 2975 NSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELM 3034
Query: 6281 TSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEE 6340
+L L+ + A++Q + K ++ L++ + + +
Sbjct: 3035 MGVLGPLS-----IDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
Query: 6341 TETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL--LGRLSLLD 6398
T + + + E++++++ + QA ++ +++++D + +G+ +
Sbjct: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
Query: 6399 SVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQI----EA 6454
S ++ + +K++L++ ++DL+ L + + + + + + EQ + +++ E
Sbjct: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209
Query: 6455 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNL 6514
+ GL++ A D++ Q ++ + Q M+DEL + ++S +N
Sbjct: 3210 VALPLQGLEDLAA---------DRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNC 3260
Query: 6515 TLKSQYERALQDLADLLETGQE--KMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMIL 6572
+ ++ ER L + E + + +G ++IV+ E + + +E
Sbjct: 3261 PISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE----------- 3309
Query: 6573 TETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR 6632
TL +++ E + H E +++ +A + S L + Q+ +
Sbjct: 3310 KRTLQNQLV------ELKNHWEELSKKTA----------------DRQSRLKDCMQKAQK 3347
Query: 6633 QLEVVESSIPSVGLVEENEDRL---IDRITLYQHL---KSSLNEYQPK--LYQVLDDGKR 6684
VE +P + + L +D + L L K+ LNE + + L ++L+
Sbjct: 3348 YQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 3407
Query: 6685 LLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQ 6741
+LI+ S +D + + + + + T ++ + LE + + +Q ++ ++
Sbjct: 3408 ILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVE 3467
Query: 6742 SAKDRLEFWTQ--QSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVL------STGN 6793
AK +LE + + LE +R +VD + ++ S +
Sbjct: 3468 GAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDAS 3527
Query: 6794 QLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWIS 6853
QLL +V R++S ++ KL + R S++
Sbjct: 3528 QLLHQAEVAQQEFLEVKQRVNS-------GCVMMENKLEGIGQFHCRVREMFSQLADLDD 3580
Query: 6854 LMENV--IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV 6911
++ + I +D D++++ I + + +L K K+DI + + +
Sbjct: 3581 ELDGMGAIGRDTDSLQSQI--EDVRLFLNKIHVLKLDIEASEAECRHMLE---------- 3628
Query: 6912 ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQE 6971
E D +L A+NK L + + LE L ++ ++ L E
Sbjct: 3629 EEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAE 3688
Query: 6972 KRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ-----NGLA--LIQNKKED 7024
+ Q +G + + N Q L D ++++V+ ++ NGL LIQ+ +D
Sbjct: 3689 EAEALQWVVGTEVEIIN-----QQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKD 3743
Query: 7025 VSSIVMS-TLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLS 7083
+ + E+ W L+ V Q L+ L + A + + S+L + ++
Sbjct: 3744 CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3803
Query: 7084 RFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLK 7143
+ + + V+ Q+ + LQ L+ ++ ++ + ++ + E +T L+
Sbjct: 3804 NQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLE 3863
Query: 7144 EVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDI 7203
+ RW LL + A + + + +L L +++ + ++ + + E + T
Sbjct: 3864 SLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAK 3923
Query: 7204 ADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLC 7263
++ D+ V ++ ++G+ L + + SL
Sbjct: 3924 IQQQIIRHKALEEDIENHATDVHQAV----KIGQSLSSLTSPAEQGVLSEKIDSLQARYS 3979
Query: 7264 ALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQG-------QDPSHS--SD 7314
++ C++ L + + F + + W+ E E+ L QD H +D
Sbjct: 3980 EIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHAD 4039
Query: 7315 LSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTT 7374
+ E + K + + L + G + L +++ ++ ++ SS+
Sbjct: 4040 HLALNEEIVNRKKNVDQAIKNGQALLK-QTTGEEVLLIQEKLDGIKTRYADITVTSSKAL 4098
Query: 7375 ERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-----QRAHELF 7429
+ + + Q+ E+ W+ + E++LA SG EQ QR EL
Sbjct: 4099 RTLEQARQLATKFQSTYEELTGWLR---EVEEELAT--SGGQSPTGEQIPQFQQRQKEL- 4152
Query: 7430 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7489
+ E+ + +L ++ + LLE R+ + ++ + Q++ V QR ID+
Sbjct: 4153 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 4212
Query: 7490 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD-EVQFKEKV-FLRQQ 7547
I++ Q+Y + A+ W+ E M+ LG PI L+Q +T +VQ + +R +
Sbjct: 4213 AIQRSQQYEQAADAELAWVAETKRKLMA-LG--PIRLEQDQTTAQLQVQKAFSIDIIRHK 4269
Query: 7548 GSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL----AFLLKD 7603
S ++ + + LQ + + +++++ S+ E+ +L + +
Sbjct: 4270 DSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 4329
Query: 7604 WEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLL 7663
WE E+ ++ +E+ R +L DH E+L +Q ++L ++ + +L +
Sbjct: 4330 WETYEE-LSPWIEETRALIAQLPSPAIDH-EQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
Query: 7664 KDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAV---FSEKNKE 7720
L ++ ++ ++ E+ + + + ++ ++ R + E +++ F +K +
Sbjct: 4388 GPQLKE-LNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEP 4446
Query: 7721 LCEWLTQMESKVSQNGDILIEEMIEKLKKDYQE-EIAIAQENKIQ-----LQQMGERLAK 7774
+ E L + S++ LI ++K+++ + + A + K+Q L++ GE L
Sbjct: 4447 MLETLENLSSRLRMPP--LIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIG 4504
Query: 7775 ASH----ESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL 7830
S + A EI+ KL ++ W+ + R K + L ++ +M++L T +
Sbjct: 4505 RSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTI 4564
Query: 7831 AHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7890
+ IV+D + + +Q E I++ + G+ L +L D
Sbjct: 4565 KDTQD-----IVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4619
Query: 7891 TDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERT 7950
+ E ++++ ++ W N+ ER K+E+ + ++ D DWL ++
Sbjct: 4620 GETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIK 4679
Query: 7951 AAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARE--NRTDSACSLK 8008
G K++L + + F+ +V++ ++E +N Q + ++ + TD ++
Sbjct: 4680 LCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDI-IR 4738
Query: 8009 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSE 8068
+ + E W+NL +++ +L+ + +F+ A + ++ WLT + +L + +
Sbjct: 4739 EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTE-ELLDAQRPIS 4797
Query: 8069 CD---VQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYC 8125
D ++ ++ + + ++ + +E + G +L+E S DA+ + L+ + +
Sbjct: 4798 GDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCW 4857
Query: 8126 QEVFGRVERYHKKL---------IRLPLPDDEHDLSDRELELEDS--------AALSDLH 8168
+ V + E ++L + D +L+ E +L S A L
Sbjct: 4858 ESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLD 4917
Query: 8169 WHDRSADSLLSPQPSSNLSLSLAQPLRSER----SGRDTPASVDSIPLEWDHDYDLSRDL 8224
H L + + + N L + + R SG T SV + +W +
Sbjct: 4918 THMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEER 4977
Query: 8225 ESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAI---KNTSGDHS 8281
+S + AL E ++F + + I P + + I K + + +
Sbjct: 4978 KSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVN 5037
Query: 8282 ALESQIRQLGKALDDSRFQIQQT----------------ENIIRSKTPTGPELDTS---- 8321
A QI +L + + +F Q+ E +++ G LD +
Sbjct: 5038 AHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRA 5097
Query: 8322 ---YKGYMKLLG-------------ECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 8365
++ + KL+ E S+ D +K K KE +++L G ++ T +
Sbjct: 5098 KQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIR 5157
Query: 8366 TAGVI---------------------DRWELLQAQALSKELRMKQNLQKWQQFNSDLNSI 8404
T + D+W+ + +++ ++ ++++ L QF L ++
Sbjct: 5158 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 5217
Query: 8405 WAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQA 8464
WL E +L + Q + D+ + + K QK + R + + E +
Sbjct: 5218 VDWLYKVEPQLAEDQ--PVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIEN 5275
Query: 8465 DSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDR- 8523
++ ++ +L +++ RWD VC L + L+ AL Q + F + H LL L ++
Sbjct: 5276 SRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQT 5335
Query: 8524 -RKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 8582
R +P D+ + L D HK+ M+ ++ E ++ V S M ++++ DC+
Sbjct: 5336 LRFRGALPDDTEA-LQSLIDTHKEFMK---KVEEKRVDVNSAVAMG-EVILAVCHPDCIT 5390
Query: 8583 A-KEKVHVIGNRLKLLLKEVSRHIKELEKLLD--VSSSQ--QDLSSW 8624
K + +I R + +L +H + LE L V++++ ++L +W
Sbjct: 5391 TIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAW 5437
Score = 261 bits (668), Expect = 2e-68
Identities = 661/3434 (19%), Positives = 1372/3434 (39%), Gaps = 384/3434 (11%)
Query: 5348 EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKL-M 5406
E ++ + L R I+ K + + L D + QAK VL EL + +
Sbjct: 1805 EHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAK----VLERELKDLTTLVSQ 1860
Query: 5407 ELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLE 5466
EL+ Q + Q ++ L K + K + Q+++ + + S L + +E
Sbjct: 1861 ELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWN------SRLLHFQNAVE 1914
Query: 5467 LILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY 5526
IEK KVL T LR ++ ++ L+ SK +SE++ + L
Sbjct: 1915 -----IEKTKVLNQHTQLEGRLQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLCLQQYED 1968
Query: 5527 CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAA-KDMKKFEAELKK-LQAALEQAQATL 5584
+ M+++ A+L +++ I Q+L + M + EL++ Q LEQ A +
Sbjct: 1969 LKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQV 2028
Query: 5585 TSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL 5644
+ + G L EQ + + L + + +++ LC S + E +A H
Sbjct: 2029 DALQ-GHLQQMEQEALVKTLQKQQNTCHQQLE--DLC-SWVGQAERALAG----HQGRTT 2080
Query: 5645 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQ 5704
Q++ S LQ ++ + + +K ++ +E ++ + + T+ ++L
Sbjct: 2081 QQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL-TALREKLH 2139
Query: 5705 AQISRHEELAQKIKGYQEQIA-SLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGE 5763
++E L ++ + Q+++ ++ S + T K+K A + LAE + +D
Sbjct: 2140 QAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAA---------KELAENKKKIDAL 2190
Query: 5764 LLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANT-DASVN 5822
L S S G+ T L + + SG + + + D
Sbjct: 2191 LDWVTSVGSS-----GGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCE 2245
Query: 5823 QDIAYYQALSAERLQTDAAKIHPSTSASQEFYE-------PGLEPSATAKLGDLQRSWET 5875
A +Q L +++ A T ++Q F + P + KLG+L+ + T
Sbjct: 2246 MMKARHQELLSQQQNFILA-----TQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300
Query: 5876 LKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEH 5932
+ + + + QK+ + + +E E +L + G SPE S +
Sbjct: 2301 SLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQ 2360
Query: 5933 QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLAL----QSTLTVLAERMSTIRM 5988
+ ++++ + ++ + S + L E+ + E + + L ER + +
Sbjct: 2361 GSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHS 2420
Query: 5989 KASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPP--KEPM 6046
K + L LN L + Q ++ AD L +W+ + +A ++ LS +P
Sbjct: 2421 KCTR----LGSHLNMLLGQYHQ------FQNSADSLQAWMQACEANVEKLLSDTVASDPG 2470
Query: 6047 DMEAQLMDCQNMLVEIEQKVVALSELS-VHNENLLLEGKA-----HTKDEAEQLAGKLRR 6100
++ QL + + E+ + V + +L V + + +EG+ H ++ + + +
Sbjct: 2471 VLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQS 2530
Query: 6101 LKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQR---Q 6157
L SL E + +L K + + QE ES QS G E + + + Q
Sbjct: 2531 LSYSLAE-RSSLLQKAIAQSQSVQESLES-----LLQSIGEVEQNLEGKQVSSLSSGVIQ 2584
Query: 6158 SSLQQQKELEQELAEQKSLL---RSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+L +L+Q++A QKS L R + +R E +AA G E Q +
Sbjct: 2585 EALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQ 2644
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK S+ ++ + E + + S K LQ +E + L G+ P
Sbjct: 2645 QEKESSLKKLLPQAE-MFEHLSGK---LQQFMENKSRM--------------LASGNQPD 2686
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
QD + + LN E+ +++++ + L +S+ LD + + V
Sbjct: 2687 QDITHFFQQIQELNLEMED--------QQENLDTLEHLVTELSSCGFALDLCQHQDRVQN 2738
Query: 6335 ALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRL 6394
L + TE +E KD E++D+ + L + +++T G
Sbjct: 2739 -LRKDFTELQKTVKE-REKDASSCQEQLDEFRKLVRTF-------QKWLKETEG------ 2783
Query: 6395 SLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEA 6454
S+ + + +++++++ + + +D T + + + E + E
Sbjct: 2784 SIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE-----INCKGTSLENLIMEITAP 2838
Query: 6455 IQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQ-ELSKLQDMYDELMMIIGSRRSGLNQN 6513
Q + G G G + +Q ++S + Y++L ++ R+ L
Sbjct: 2839 DSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAI 2898
Query: 6514 LTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE-IQQLLDKHKEYFQGLESH--- 6569
L + + + LE+ +E + + +K E ++ + +K + LE +
Sbjct: 2899 LNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPK 2958
Query: 6570 -MILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE-TWSHL---D 6624
+ E L ++++ +E + ++ + ++ +RA + V + LE + SHL
Sbjct: 2959 IQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQ 3018
Query: 6625 EDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKR 6684
+ +L L E + +G + + + L + Q + + + Q+ + +
Sbjct: 3019 AAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG 3078
Query: 6685 LL-----ISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHW 6739
+L +S+S S ++ +L + + W+ T+K++ +++ + T+YQ DL
Sbjct: 3079 ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEK 3138
Query: 6740 LQSAKDRLEFWTQ---QSVTVPQELEMVRDHLNAFLEFSKEV-DAQSSLKSSVLSTGNQL 6795
+++ RL + Q V Q+LE + + + EV +AQ+ + G Q
Sbjct: 3139 VRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQY 3198
Query: 6796 LR---LKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWI 6852
L+ K+++T L L ++ D + + A Q Q E+ +W+
Sbjct: 3199 LKDELKKRLETVAL--PLQGLEDLAADRINRLQAALASTQQFQQ-------MFDELRTWL 3249
Query: 6853 SLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFV---NQSVLQISSQ 6909
++ K N S + + LQ+ + F+ +N + + + +S+L +S
Sbjct: 3250 DDKQSQQAK---NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLL-LSVP 3305
Query: 6910 DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFET 6969
E KR+ QL + W+ L ++ L+ ++ +Y+ +V+ L W E
Sbjct: 3306 PGEEKRT----LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIED 3361
Query: 6970 QEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSI- 7028
+ ++ + D ++++L + + + ++ + +E + LI + + D I
Sbjct: 3362 CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIR 3421
Query: 7029 ---------VMSTLRELGQTWANLDHMVGQLKILLKSVLD-----QWSSHKVA-FDKINS 7073
+ + EL +L+ M +L+ +S + + + H++ FD + S
Sbjct: 3422 DEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGS 3481
Query: 7074 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7133
+ +L + R L+A++ QVD L+N L + GS +QLL +
Sbjct: 3482 QACSNK-NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVA 3536
Query: 7134 VTETLTNTLKEVNMRWNN---LLEEIAEQL-QSSKALLQLWQRYKDYS----------KQ 7179
E L EV R N+ ++E E + Q + +++ + D +
Sbjct: 3537 QQEFL-----EVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRD 3591
Query: 7180 CASTVQQQEDRTNELLKAATNK-DIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQ 7238
S Q ED L K K DI E +C +L+ GT+ D L EL
Sbjct: 3592 TDSLQSQIEDVRLFLNKIHVLKLDIEASEA-----ECRHMLEEEGTL-DLLGLKRELEAL 3645
Query: 7239 LKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIV 7298
KQ + + +QL L+ L +E K + G+ D T A+ EAL+ W+V
Sbjct: 3646 NKQCGKLTERGKARQEQLELT--LGRVEDFYRKLK-----GLNDATTAAEEAEALQ-WVV 3697
Query: 7299 EAE-EILQGQDPSHSSDLSTIQ-ERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEI 7356
E EI+ Q +D Q E+++ L+ ++ + + + L + G + E
Sbjct: 3698 GTEVEIINQQ----LADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE- 3750
Query: 7357 KRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEI--SG 7414
M+ +N W+ ++ + +R ++LQ LL F + E + +L TE+ +A + S
Sbjct: 3751 HDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSA 3810
Query: 7415 NYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQ 7474
Y+ + Q + +L Q + R+ + + +G R+ + ++ DR++ +L L ++W
Sbjct: 3811 EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWT 3870
Query: 7475 GVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFD 7534
++ +A R+ ++ + +++ E AE + +L S S P+ Q A+
Sbjct: 3871 ELLSKAAARQKQLEDILVLAKQFHETAEPISDFL---SVTEKKLANSEPVGTQTAKIQQQ 3927
Query: 7535 EVQFK--EKVFLRQQGSYILTVEAGKQLLLSADSGAEA--------ALQAELAEIQEKWK 7584
++ K E+ V+ G Q L S S AE +LQA +EIQ++
Sbjct: 3928 IIRHKALEEDIENHATDVHQAVKIG-QSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986
Query: 7585 SASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKL-----RTFKKKLSQSLPDHHEELHAE 7639
+ L++ +D + +A+ +KL + FK+ + H L+ E
Sbjct: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEE 4046
Query: 7640 QM-RCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLS 7698
+ R K ++ A+ + +LLK T + +++ ++ E+++ ++ ++ ++ S
Sbjct: 4047 IVNRKKNVDQAIKNGQ------ALLKQT-----TGEEVLLIQEKLDGIKTRYADITVTSS 4095
Query: 7699 LRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG-DILIEEMIEKLKKDYQEEIAI 7757
+ + + F +EL WL ++E +++ +G E I + ++ +E
Sbjct: 4096 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKE 4155
Query: 7758 AQENKIQLQQMGERLAKASHES---KASE-IEYKLGKVNDRWQHLLDLIAARVKKLKETL 7813
E+++ L + E +++A E +A E ++ + N++++ + D I RV ++ +
Sbjct: 4156 VMEHRLVLDTVNE-VSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI 4214
Query: 7814 VAVQQLDKNMSSLRTWLAHIESELAK--PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTG 7871
QQ ++ + W+A + +L PI + ++ +L Q+ DI +H
Sbjct: 4215 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQ---DQTTAQLQVQKAFSIDIIRHKDS 4271
Query: 7872 VASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQ 7931
+ + + + C + + +Q+ T +L +++ I ++ ER ++E L
Sbjct: 4272 MDELFSHRSEIFGTCG----EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVN 4327
Query: 7932 KFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
+F + Y W++ + A S + + +++ ++ + + E ++ + K
Sbjct: 4328 QFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 4387
Query: 7992 YRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRR----LKHFIGQREEFETARD 8047
+L N + +MV E Q+ +N+ ++ +R+ L + Q + D
Sbjct: 4388 GPQLKELNPEEG-----EMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 4442
Query: 8048 SILVWLTEMD----------LQLTNIEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIA 8097
I L ++ L ++ EC I K+ E+ E +
Sbjct: 4443 KIEPMLETLENLSSRLRMPPLIPAEVDKIREC-----ISDNKSATVELEKLQPSFEALKR 4497
Query: 8098 QGEQLIEKSEPLD----AAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSD 8153
+GE+LI +S+ D A I+++LD++ + +++ R E +
Sbjct: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAE-------------------E 4538
Query: 8154 RELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLE 8213
RE++ D L++ W+D +A L + + + ++ L P + + ++I E
Sbjct: 4539 REIKFLDVLELAEKFWYDMAA-LLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEE 4597
Query: 8214 WDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAI 8273
D L +LE G+ +K + I E A+ EN
Sbjct: 4598 TD---GLHEELEFIRILGADLIFACGETEKPEVRKS--------IDEMNNAW----ENLN 4642
Query: 8274 KNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECS 8333
K LE ++ + D + +N + K T P + T L E
Sbjct: 4643 KTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV-IKLCTMPPVGTDLNTVKDQLNEMK 4701
Query: 8334 SSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDR---------WELLQAQALSKE 8384
V+ + +++ E+ + G + L +T I R WE L + ++
Sbjct: 4702 EF--KVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQ 4759
Query: 8385 LRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAV 8444
+++ L QF L + +WL TEE L+ + +S D + IE+++ K L+ V
Sbjct: 4760 HKLEGALLALGQFQHALEELMSWLTHTEELLDAQR--PISGDPKVIEVELAKHHVLKNDV 4817
Query: 8445 DHRKAIILSINLCSPEFTQADS-KESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQ 8503
+A + ++N E ++ + ++ L+ RL MN W+ V EE LQ L Q
Sbjct: 4818 LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQ 4877
Query: 8504 CQGFHEMSHGLLLMLENIDRRKNEIVPIDS--NLDAEILQDHHKQLMQIK------HELL 8555
QGFH LL L ++ + + P E L H + Q+K ++LL
Sbjct: 4878 AQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLL 4937
Query: 8556 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS 8615
+ + +D S + LE +K HV+ ++++ + S+ + L +
Sbjct: 4938 DKGRLMLLSRDDSGSGSKTEQSVALLE--QKWHVVSSKME---ERKSKLEEALNLATEFQ 4992
Query: 8616 SSQQDLSSWSSADE 8629
+S Q+ +W + E
Sbjct: 4993 NSLQEFINWLTLAE 5006
Score = 253 bits (646), Expect = 6e-66
Identities = 715/3988 (17%), Positives = 1507/3988 (37%), Gaps = 601/3988 (15%)
Query: 1863 ASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQN 1922
A+Q V RQL L H E L S+ SL LR T + E +L E L D L
Sbjct: 1793 ATQNVFTRQLCLEH-DEKLVSYLSL------LRNIEMRTKQIQPLELNLAE--LQDLLCQ 1843
Query: 1923 AKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADA 1982
AK LE L ++S+ E+E + ++ ++ E A
Sbjct: 1844 AKVLERELKDLTTLVSQ-------------------------ELECVNQIIISQPQEVPA 1878
Query: 1983 LAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHEL 2042
L KA + + L KS+ + + T RL ++ +V NQ +L +L
Sbjct: 1879 Q--LLKALEKDAKNLQKSLSSVSD-TWNSRLLHFQNAVEIEKTKVLNQ-HTQLEGRLQDL 1934
Query: 2043 -CWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI--------- 2092
W+ +K + K +VD +N ++D K+ + E + Q L
Sbjct: 1935 RAWVGNKNLILNSKGSNSEIDVD-SLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISE 1993
Query: 2093 -----------DLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2141
++R L+ + +LE ++ + Q + + + +N
Sbjct: 1994 HAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNT 2053
Query: 2142 MNYKQKDLDNFTSKGKHLL------------SELKKIHSSDFSLVKTDMESTVDKWLDVS 2189
+ + +DL ++ + + L S L+K + SD ++ D+++ + V
Sbjct: 2054 CHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQK-NQSDLKDLQDDIQNRATSFATVV 2112
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFES 2249
+ +E M+ + LS ++ + R+++ Q E L R + KE E
Sbjct: 2113 KDIEGFMEENQTKLSP-RELTALREKLH--------QAKEQYEALQEETRVAQ--KELEE 2161
Query: 2250 EVKNKALRLEELHSKVNDLKELTKNLETPPD-LQFIEADLMQKLEHAKEITEVAKGTLKD 2308
V + + E +L E K ++ D + + + Q L + + +++ +L+
Sbjct: 2162 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEK 2221
Query: 2309 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSN-ISSTQ 2367
+T +N + E L ++ CE +K +EL SQQ N I +TQ
Sbjct: 2222 GALDTTDGYMGVN-------QAPEKL-----DKQCEMMKAR---HQELLSQQQNFILATQ 2266
Query: 2368 ENLNSLCRKYHSA--ELESLGRAMTGLIKKHEAVSQLCSKTQA----SLQESLEKHFSES 2421
L + H+ E + + + G +K+ + S S+ + +LQ+ L+K F +
Sbjct: 2267 SAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQK-FLQD 2325
Query: 2422 MQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLY 2481
+EF+ W ++ + + L + L + + V + L VT GQ +
Sbjct: 2326 HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVL 2385
Query: 2482 --------AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2533
+I + +++++ A E + A +C + L + F++
Sbjct: 2386 DMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADS 2445
Query: 2534 LNLWIHEME---ERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL 2590
L W+ E E+ ++ + + E+ +++ L E E L K+++ +
Sbjct: 2446 LQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVAR--DI 2503
Query: 2591 LSEEGHGAGQEGRL---CSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWV 2647
+ EG A + +L+ Q+L E+ Q A+ + ++++E+L+S+ +
Sbjct: 2504 MEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSI 2563
Query: 2648 KAIQDRLACAE-STLGS---KDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSN 2703
++ L + S+L S ++ L + QDI K E M + + +++
Sbjct: 2564 GEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVT----RFMETAD 2619
Query: 2704 KEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKI 2763
V+Q +L + + + + +S+L+ ++ Q + +L+Q+ME+ + +
Sbjct: 2620 STTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRML 2679
Query: 2764 EHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEE 2823
QP + F + L + + +++ L L+ + + +D Q
Sbjct: 2680 ASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQN- 2738
Query: 2824 LKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSAT 2883
L+ F ++ KE+ + + + V F WL + + ++ S +
Sbjct: 2739 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPP-TETSMSAKEL 2797
Query: 2884 QKKLSKIKELIDS--------REIGASRLSR----VESLAPEVKQNT------------- 2918
+K++ +K L+D EI S +E AP+ + T
Sbjct: 2798 EKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGS 2857
Query: 2919 ----------TASGCEL-------------MHTEMQALRA----------------DWKQ 2939
T C++ +H ++L+A W +
Sbjct: 2858 VNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLE 2917
Query: 2940 WEDSVFQTQSCLEN-----LVSQMALSEQEFSGQVAQ----LEQALEQFSALLKTWAQQL 2990
++ V ++ + + V A S + F ++ Q +++ E + LL T+
Sbjct: 2918 SKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQ 2977
Query: 2991 TLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQL-------NELCRFSRDLSTY 3043
K EE+ W + E+ A Q+ + E+ S L ++L + +
Sbjct: 2978 EAENWKKIQEELNSRWERATEVTVARQR---QLEESASHLACFQAAESQLRPWLMEKELM 3034
Query: 3044 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3103
G + L + N L Q + + Q + + F + +Q A+ D+ +
Sbjct: 3035 MGVLGPLSIDPNMLNAQ-----KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLS 3089
Query: 3104 ISEVSTSLQKIQ----EFLSESENGQHKLNMMLSKG----ELLSTLLTKEKAKG----IQ 3151
S+V LQ I E + + +++ + K ELL L K +A G +Q
Sbjct: 3090 TSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
Query: 3152 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE---------VSAEPIQDWLSKTEKM 3202
+ ++ E K + S LE L ++K+ + + + ++D L K +
Sbjct: 3150 SAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLET 3209
Query: 3203 VHESSNRLYDLPAKRREQ--------QKLQSVLEEIHCY--------------EPQLNRL 3240
V L DL A R + Q+ Q + +E+ + +L RL
Sbjct: 3210 VALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL 3269
Query: 3241 KEKAQQLWEGQAA---------------------------SKSFRHRVSQLSSQYLALSN 3273
+ + Q+ E Q + ++ ++++ +L + + LS
Sbjct: 3270 QSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK 3329
Query: 3274 LTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEAL 3333
T ++ SRL + + ++ +++L W+ D + S T D L+S L+ +A+
Sbjct: 3330 KTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKM-SELRVTLDPVQLESSLLRSKAM 3388
Query: 3334 LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEG 3393
L+ + EK + I+ +L N+S + ++D A + +L+
Sbjct: 3389 LN-EVEKRRSLLEILNSAADILINSS-------EADEDGIRDEKAGINQNMDAVTEELQA 3440
Query: 3394 ALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLL 3453
+R+F ++E + E + E+ D + E++ + +L
Sbjct: 3441 KTGSLEEMTQRLREFQESFKNIEKKV-EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVL 3499
Query: 3454 ETIEVK-------GAGMTEHYVTQLELQDL-------QERYRAIQERAKEAVTKSE-KLV 3498
+ +E + G+ E + L Q+ + +++R E KL
Sbjct: 3500 QALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLE 3559
Query: 3499 RLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQ-------ELQVHCAE 3551
+ Q + R + F L ++LD + D + ++ + D++ L++
Sbjct: 3560 GIGQFHCRVREMFSQ-LADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEA 3618
Query: 3552 GQALLNSVLHTREDVIPSGIP---QAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLR 3608
+A +L + G+ +A ++ L + +A Q +L T + + KL+
Sbjct: 3619 SEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLK 3678
Query: 3609 LMEQKFQQVDE-----WLKTAEEKKWHEEVTAYR----DEVEEVGARAQEI--LDESHVN 3657
+ +E W+ E + ++++ ++ ++V+ + + Q++ L + +
Sbjct: 3679 GLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQ 3738
Query: 3658 SR--------MGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGST 3709
S + ++ +R+ L +V ++I L+E + + + +L W T
Sbjct: 3739 SAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADT 3798
Query: 3710 HK---NFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEG 3766
+ N K + + V + +KL L+ LL D + +L++ +G R + E
Sbjct: 3799 EELIANQKPPSAEYKVVKAQIQEQKL--LQRLLDDRKATVDMLQA---EGGRIAQSAELA 3853
Query: 3767 EAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHV 3826
+ E++ ++ + EL S LE L LAK+F + + ++ +++ ++ L
Sbjct: 3854 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3913
Query: 3827 PEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV---TLKDKIDQ 3883
E + + + Q+ ++K+L++ + +H V + G++L L L +KID
Sbjct: 3914 SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDS 3973
Query: 3884 LQSDY---QDLCSIGKAMMEE------------------IAGFEDRLNNL---QMKGDTL 3919
LQ+ Y QD C A++++ +A ED+L+++ K D L
Sbjct: 3974 LQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVL 4033
Query: 3920 IGQCADHL--------------------QAKLKQN-------VHAHLQGTKDSYSAICST 3952
Q ADHL QA LKQ + L G K Y+ I T
Sbjct: 4034 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVT 4093
Query: 3953 AQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQ 4012
+ + ++LE Q Q T ++ WL V+ +L S ++ +Q+ F+ Q
Sbjct: 4094 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSG----GQSPTGEQIPQFQQRQ 4149
Query: 4013 EQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELW 4072
++ + + + D N + + + + KLV N E+ K + +
Sbjct: 4150 KELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDAN-----EQYKLVSDTIG 4204
Query: 4073 IYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK-----KLQSKQASVNTIIEKVNK 4127
+ + D +Q ++ + +A V++ K + +L+ Q + ++K
Sbjct: 4205 QRVDEIDAAIQRSQQYEQAADAELA--WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 4262
Query: 4128 LTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQRE-EDLQRTRDYHDCMNV--------V 4178
+ E+ + C + LQ + E L + + +N
Sbjct: 4263 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 4322
Query: 4179 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEH---- 4234
+V + +F ++ L+ E+ A+ + L A+ ++ + E+++ ++ + EH
Sbjct: 4323 QVLVNQFWETYEELSPWIEETRAL-IAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 4381
Query: 4235 ------------LNLDDKELVKEQTSHLEQRWFQLEDLIKRK---IQVSVTNLEELNVVQ 4279
LN ++ E+V+E+ E + Q+++ ++++ + +V+ ++
Sbjct: 4382 DKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFH 4441
Query: 4280 SRFQELMEWAEEQQPNIAEALKQSP----PPDMAQNLLMDHLAICSELEAKQMLLKSLIK 4335
+ + ++E E N++ L+ P D + + D+ + ELE Q ++L +
Sbjct: 4442 DKIEPMLETLE----NLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKR 4497
Query: 4336 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRR-----KYLNKA-LSEKTQFLM 4389
+ ++ ++ + K + D + + + R K+L+ L+EK + M
Sbjct: 4498 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDM 4557
Query: 4390 AVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGREL 4449
A T I+ + + E + P + +QV+ ++ + E+ + G +L
Sbjct: 4558 AALLTT--IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADL 4615
Query: 4450 MKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQ 4509
+ E EK EV + E+ + ++++ + RL++LE + + +++ WL
Sbjct: 4616 IFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDN 4675
Query: 4510 ADI--VTFPEINL-MNESSELHTQLAKYQ-NILEQSPEYENLLLTLQRTGQTILP-SLNE 4564
I T P + +N + ++ +++ + +Q E E L G+ +L + +E
Sbjct: 4676 TVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL----NHQGELMLKKATDE 4731
Query: 4565 VDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIE-----LT-TQSLSE 4618
D + E L L + + + +K++ A+LA ++ +E LT T+ L +
Sbjct: 4732 TDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLD 4791
Query: 4619 -----------LEAQFLRMSKVPTDLAVEEAL--SLQDGCRAILDEVAGLGEAVDELNQK 4665
+E + + + D+ +A ++ +L+ AG D+ +
Sbjct: 4792 AQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG-----DDASSL 4846
Query: 4666 KEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLER---Q 4722
+ + Q W+ ++ + + + +Q S L+ + E E +L R Q
Sbjct: 4847 RSRLEAMNQCWE--------SVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQ 4898
Query: 4723 LKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEK 4782
L + K + +++Y L + +L + + L D + K
Sbjct: 4899 LSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLML---LSRDDSGSGSK 4955
Query: 4783 ARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYL 4842
+ + + +++S + E ++ E + + +FQ + ++WL + L+
Sbjct: 4956 TEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPP 5015
Query: 4843 DLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELISADLEHSLAELSE 4901
L L + +I + ++ EV + + L + KF K+ + ++ S
Sbjct: 5016 SLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSR 5075
Query: 4902 LDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENL 4961
+ +Q ++ R +L + + +++++ ++ DWLEDA E +L
Sbjct: 5076 WEKVVQRSIE-RGRSLDDARKRAKQFHEAWKKLIDWLEDA----------------ESHL 5118
Query: 4962 KSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQ 5021
S +E + D+ L + TL GK Q V +R+ R ++
Sbjct: 5119 DSELEISNDPDKIKLQLSKHKEFQKTLG------GK----QPVYDTTIRTGRALKEK--- 5165
Query: 5022 VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVV 5081
T D QK + + + K H+ EE L + +
Sbjct: 5166 -------TLLPEDSQK----LDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDAL 5214
Query: 5082 NSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQ-----RWTRLRAVAQDQEKILE 5136
+ + + +E + ++ + D V+Q R ++ + + +++E
Sbjct: 5215 QALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIE 5274
Query: 5137 DAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSA 5196
++ D+ T ++++ + D + KL S + +A L + DT + LE A
Sbjct: 5275 NSRDDTTWVKGQLQELSTRWDTVC-KLSVSKQSRLEQA-LKQAEVFRDTVHMLLEWLSEA 5332
Query: 5197 LGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEK-VKTNGKLVKQELKDRE 5255
+QTL GA P E L I ++ ++EK V N + E+
Sbjct: 5333 -----EQTLRFR--GALPDDTEA--LQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAV 5383
Query: 5256 MVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL 5315
I ++K W+ TI I A+ EE+ LT A H+Q +E E
Sbjct: 5384 CHPDCITTIKHWI----------TI-IRARFEEV---LTWAKQHQQRLETALSELVANAE 5429
Query: 5316 GLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILT 5375
L +L +Q AE L + ++ I I V+ A Q ++ + D+ +
Sbjct: 5430 LLEELLAW---IQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTK 5486
Query: 5376 KLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTE 5435
K K A +K G L + L Q+ + +I +L+
Sbjct: 5487 TYKRKNIEPTHAPFIEK----SRSGGRKSLSQPTPPPMPILSQS----EAKNPRINQLSA 5538
Query: 5436 LHQQTIRQAENRLSKLNQAASHLEEYNE 5463
QQ A R KLN A LEE E
Sbjct: 5539 RWQQVWLLALERQRKLNDALDRLEELKE 5566
Score = 251 bits (642), Expect = 2e-65
Identities = 653/3634 (17%), Positives = 1374/3634 (37%), Gaps = 466/3634 (12%)
Query: 743 EVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQE----EGKEMFATMSK 798
E+ ++ L +Q ED++Q + AQ + E Q+ + ++M +++
Sbjct: 1953 EIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNE 2012
Query: 799 LKEQLTKVKECYSPLLYESQQLLIPLEE------LEKQMTSFYDSLGKINEIITVLEREA 852
L+ + E + + Q L +E+ L+KQ + + L + + ER A
Sbjct: 2013 LQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER-A 2071
Query: 853 QSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHF-----------DQ 901
+ + Q+L A Q+N L + F T+ ++ F +
Sbjct: 2072 LAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPREL 2131
Query: 902 TRLQRQIADIHVAFQSMVKKTGDWKKHVE--TNSRLMKKFEESRAELEKVLRIAQEGLEE 959
T L+ ++ ++++ ++T +K +E S L ++ E+S+A A+E E
Sbjct: 2132 TALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKA--------AKELAEN 2183
Query: 960 KGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQ-------QGLQEAVRKLH 1012
K + LL T S Q + N L ++L+ E+ G+ +A KL
Sbjct: 2184 KKKIDALLDWVTSVGSSGGQLLTN--LPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLD 2241
Query: 1013 KQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFF 1072
KQ C R +L+ Q+ + + + F
Sbjct: 2242 KQ------------------------------CEMMKARHQELLSQQQNFILATQSAQAF 2271
Query: 1073 SDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK 1132
D+ H+L + Q++++ +L ++ + LK+++ D +K ++D
Sbjct: 2272 LDQHGHNLTPEEQQMLQQKLGEL--KEQYSTSLAQSEAELKQVQTLQDEL-QKFLQD--- 2325
Query: 1133 WKDYTSRFSEFSSWISTNETQLKGI-KGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWL 1191
EF SW+ +E +L+ + KG + +KR + ++ +G+
Sbjct: 2326 -------HKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVT 2378
Query: 1192 KSRLKVLTEVSSENEAQKQGDELA-----KLSSSFKALVTLLSEVEKMLSNFGDCVQYKE 1246
S KVL +S E K+ E+ KL + + L S+ ++ S+ +
Sbjct: 2379 ISGQKVLDMENSFKEG-KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYH 2437
Query: 1247 IVKNSLEELISGSKEVQEQAEKIL-DT---------ENLFEAQQL---LLHHQQKTKRIS 1293
+NS + L + + + EK+L DT E L +QL L HQ +++
Sbjct: 2438 QFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQ 2497
Query: 1294 AKKRDVQQQIAQAQQGEGGLPDRGH--EELRKLESTLDGLERSRERQERRIQVTLRKWER 1351
RD+ + +GE PD H E + S L S + +Q + + +
Sbjct: 2498 KVARDIME-----IEGEPA-PDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQS 2551
Query: 1352 FETNKETVVRYLFQTGSSHE--RFLSFSS---LESLSSELEQTKEFSKRTESIAVQAENL 1406
+ + E++++ + + + E + S SS E+L++ ++ ++ +++ S+ E +
Sbjct: 2552 VQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMV 2611
Query: 1407 VK-----EASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSN 1461
+ +++ + + Q+ + + Q ++ E +L++ + EM
Sbjct: 2612 TRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEM----------- 2660
Query: 1462 FETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFV 1521
FE LS + + + + + S + D I+ IQE+ ++ +E + V
Sbjct: 2661 FEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMED---QQENLDTLEHLV 2717
Query: 1522 TTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDK 1581
T S L Q + + LR+ L+ T+ +E L + ++ V F+
Sbjct: 2718 TELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKW 2777
Query: 1582 L------AVPIKICSSATETYKVLQEHMDLCQ-----------------ALESLSSAITA 1618
L P + SA E K ++ L +LE+L ITA
Sbjct: 2778 LKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITA 2837
Query: 1619 -------------FSASARKVVNRDSCVQ------EAAALQQQYEDILRRAKERQTALEN 1659
+S V +C + + + +YE + ERQ +L+
Sbjct: 2838 PDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA 2897
Query: 1660 LLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASF 1719
+L + + KE +S L WLE E S MD + K E ++ + +
Sbjct: 2898 ILNRMEEVHKEANSVLQWLESKEEVLKS--MDAMSSPTKTETVKAQAESNKAFLAELEQN 2955
Query: 1720 YSKLLQLKES----LFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQ 1775
K+ ++KE+ L + + + + K E+L+ RW ++ R L+ +
Sbjct: 2956 SPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLA 3015
Query: 1776 QFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLA 1835
F W+ + +SI + + + + E + Q Q + A
Sbjct: 3016 CFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEA 3075
Query: 1836 KLGSLGRAEDLHLLQGKAEDCFQ-LFEEASQVVERRQLALSHLAEFLQSHASLSGILRQL 1894
G L D+ L + + Q + ++ ++ ++ S + + + +L+ L
Sbjct: 3076 AQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDL 3135
Query: 1895 RQTVEATNSMNKNESDLIEKD--LNDALQNAKALESAAVSLDGILSKAQ-----YHLKIG 1947
+ V A +S + + + L+ + S LD + +AQ + IG
Sbjct: 3136 SEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIG 3195
Query: 1948 SSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEER 2007
+ + + + ++ +++L + + A + FQ +EL ++D + +
Sbjct: 3196 EQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQ 3255
Query: 2008 TDKERLKEPTRQALQQRLRVFNQLEDELNSH--EHELCWLKDKAKQIAQKDVAFAPEVDR 2065
K + LQ +L+ + + LN H +E+ + ++ ++ +
Sbjct: 3256 QAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQN 3315
Query: 2066 EINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQ-NLKSAVSKVLENASSVIVTRTTIKD 2124
++ L+ W++ + + Q + + ++YQ +++ V + + + + R T+ D
Sbjct: 3316 QLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTL-D 3374
Query: 2125 QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHS---SDFSLVKTDMEST 2181
L+ + + + N++ ++ L+ S L++ + + + + +M++
Sbjct: 3375 PVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAV 3434
Query: 2182 VDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE 2241
++ + LEE RLR + + ++EG A++ + + L ++
Sbjct: 3435 TEELQAKTGSLEEMTQRLR---EFQESFKNIEKKVEG---------AKHQLEIFDALGSQ 3482
Query: 2242 ELLKEFESEVKNKALRLEELHSKVNDLKELTKNL-ETPPDLQFIEADLMQKLEHAKEITE 2300
+ +++ + L+ L +V+ L+ T+ L E PD +D Q L A+ +
Sbjct: 3483 ACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPD----GSDASQLLHQAEVAQQ 3538
Query: 2301 VAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQ 2360
+ + +E + I + +V E A + + L + I ++ S Q
Sbjct: 3539 EFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD--DELDGMGAIGRDTDSLQ 3596
Query: 2361 SNISSTQENLNSL-------------CRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQ 2407
S I + LN + CR H E E + GL ++ EA+++ C K
Sbjct: 3597 SQIEDVRLFLNKIHVLKLDIEASEAECR--HMLEEEGT-LDLLGLKRELEALNKQCGKLT 3653
Query: 2408 ---ASLQESLEKHFSESMQEFQEWFLG---AKAAAKESSDRT----GDSKVLEAKLHDLQ 2457
+ QE LE +++F G A AA+E+ + +++ +L D +
Sbjct: 3654 ERGKARQEQLELTLGR-VEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3712
Query: 2458 NI-LDSVSDGQSKLDAVTQEGQTLYAHLSKQI-VSSIQEQITKANEEFQAFLKQCLKDKQ 2515
+ V Q KL V GQ L K V ++ + + N + K+ +
Sbjct: 3713 MFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA 3772
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
LQ+ G F+D L W+ + EE + Q P + +V K ++ +LL
Sbjct: 3773 QLQEALLHCGKFQDALEPLLSWLADTEELI-------ANQKPPSAEYKVVKAQIQEQKLL 3825
Query: 2576 AARESLDKLSQRGQLLSEEGHGAGQEGRLCS-QLLTSHQNLLRMTKEKLRSCQVALQEHE 2634
+ LD +L EG Q L + +T L +L S A Q+
Sbjct: 3826 --QRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQ- 3882
Query: 2635 ALEEAL---QSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE------ 2685
LE+ L + + I D L+ E L + + + + ++IQ ++ E
Sbjct: 3883 -LEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENH 3941
Query: 2686 -VKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWND 2744
++ A+ G+ ++ Q V+ ++++L+ +++I + L+ +S
Sbjct: 3942 ATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL 4001
Query: 2745 YVERKNQLEQWMESVDQKIEHPLQ---PQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2801
+ E + ++ W+ V+ K+ Q L + DHL ++ E + + + + I
Sbjct: 4002 FGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHA--DHL-ALNEEIVNRKKNVDQAI 4058
Query: 2802 AKSRELYEKTEDESFKDTAQEEL---KTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2858
+ L ++T E QE+L KT++ DI + + +R +E+ + + E
Sbjct: 4059 KNGQALLKQTTGEEVL-LIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEE 4117
Query: 2859 FTDWLHSAKEELHRWSDMSGDSSAT-------QKKLSKIKELIDSREIGASRLSRVESLA 2911
T WL +EEL SG S T Q++ ++K+ + + ++ V
Sbjct: 4118 LTGWLREVEEEL----ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRAL 4173
Query: 2912 PEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQ 2971
E+ G + + ++ +K D++ Q ++ + + EQ ++A
Sbjct: 4174 LELVPWRAREGLDKLVSD---ANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAW 4230
Query: 2972 LEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTE--DLKSQ 3029
+ + + AL +Q D+ + + +D ++ + E +S+
Sbjct: 4231 VAETKRKLMALGPIRLEQ---------DQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 4281
Query: 3030 LNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKE--QILQQRFRKAFRDFQQWL 3087
+ C + K LI++Y + L S+ E Q+L +F + + + W+
Sbjct: 4282 IFGTCG-EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWI 4340
Query: 3088 VNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESEN-GQHK--LNMMLSKGELLSTLLTK 3144
+ A+ +P + Q+ +E E+ +HK ++ +L G L L
Sbjct: 4341 EETRALIAQ---LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKE-LNP 4396
Query: 3145 EKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVH 3204
E+ + ++ K A+ + + Q+ AL+ Q + I+ L E +
Sbjct: 4397 EEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENL-- 4454
Query: 3205 ESSNRLYDLPAKRREQQKL-------QSVLEEIHCYEPQLNRLKEKAQQL------WEGQ 3251
S+RL P E K+ +S E+ +P LK + ++L +
Sbjct: 4455 --SSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKD 4512
Query: 3252 AASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLD 3311
A+K + ++ Q+ + + +E+ + ++ +F + L + D ++
Sbjct: 4513 LAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVH 4572
Query: 3312 SYCHPTSDKSVLDSRTLKLEALLSVKQEKE---IQMKMIVTRGESVLQNTSPEGIPTIQQ 3368
P D S++ ++EA ++K+E + +++ I G ++ P +++
Sbjct: 4573 DLESPGIDPSIIKQ---QVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRK 4629
Query: 3369 QLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAE 3428
+ + + W +L +LE A+ YQD ++ W+D+ L +
Sbjct: 4630 SIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTD 4689
Query: 3429 LRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGM-------TEHYVTQLELQDLQERYR 3481
L L + K EV +E + +G M T+ + + L +L+ +
Sbjct: 4690 LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWE 4749
Query: 3482 AIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLD-----------------Q 3524
+ E+ K E + ++Q L+ WL +E LD +
Sbjct: 4750 NLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAK 4809
Query: 3525 YSVLEGDAHTHETTLRDLQE-----LQVHCAEGQALLNSVLHTREDVIPSGIPQAEDR-- 3577
+ VL+ D H+ T+ + + L+ + + L S L S + + E+R
Sbjct: 4810 HHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQ 4869
Query: 3578 ALESLRQDWQAYQHRLSETRTQFNNVVNKLR-------LMEQKFQQVDEWLKTAEEKKWH 3630
L+S Q Q + + + + + ++L L E +Q+D ++ + K
Sbjct: 4870 QLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAK 4929
Query: 3631 EEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQ 3690
EE +++ + G D+S S+ L ++ + ++ E+ LEE +
Sbjct: 4930 EET---YNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALN 4986
Query: 3691 SLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLK 3750
E ++SL + +W ++ + ++TV+ +++ +V ++ +
Sbjct: 4987 LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVL--SQIEEHKVFANEVNAHRDQII 5044
Query: 3751 SAREKGERAVKYLEEGEAERLRKEIHDHME-QLKELTSTVRKEHMTLEKGLHLAKEFSDK 3809
+ G + +K+L + + L K + ++ + +++ + +L+ AK+F +
Sbjct: 5045 ELDQTGNQ-LKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEA 5103
Query: 3810 CKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALL 3869
K L W+ + + L E + + K QLSK+K Q+T+ +P
Sbjct: 5104 WKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLGGKQP------------- 5150
Query: 3870 ELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA 3929
V D T++ G+A+ E+ ED K D +G+
Sbjct: 5151 --VYDTTIR---------------TGRALKEKTLLPED-----SQKLDNFLGE------- 5181
Query: 3930 KLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDL- 3988
+D + +C + LE L D LQ WL V+P L
Sbjct: 5182 ------------VRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLA 5229
Query: 3989 EPSP------------------QPPLSRAEAIKQV--KHFRALQEQARTYLDLLCSMCDL 4028
E P Q L + QV + R L E +R +
Sbjct: 5230 EDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQE 5289
Query: 4029 SNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRR 4088
+ T K + +EQ L QA + + + H+ E +L +A+Q L+
Sbjct: 5290 LSTRWDTVCKLSVSKQSRLEQALKQA----EVFRDTVHMLLE---WLSEAEQTLRFRGAL 5342
Query: 4089 HSELELNIAQNMVSQVKDFVKKLQSKQASVNTII 4122
+ E Q+++ K+F+KK++ K+ VN+ +
Sbjct: 5343 PDDTE--ALQSLIDTHKEFMKKVEEKRVDVNSAV 5374
Score = 225 bits (573), Expect = 2e-57
Identities = 563/3336 (16%), Positives = 1277/3336 (38%), Gaps = 328/3336 (9%)
Query: 314 NSVQNFKREDRVIFKEMKVWIEQFERDLTRAQM--VESNLQDKYQSFKHFRVQYEMKRKQ 371
+ +QN + K+++ ++E+ + L+ ++ + L + ++ + + + +K+
Sbjct: 2099 DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKE 2158
Query: 372 IEHLI-QPLHRDGKLSLDQALVKQSWDRVTSRLFDWHI-------QLDKSLPAPLGTIGA 423
+E + L ++ + S + ++ ++ + L DW QL +LP GA
Sbjct: 2159 LEEAVTSALQQETEKSKAAKELAENKKKIDA-LLDWVTSVGSSGGQLLTNLPGMEQLSGA 2217
Query: 424 WLYRAEVALREE-ITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGI 482
L + + + + V Q E+ + +H++LL A +G
Sbjct: 2218 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 2277
Query: 483 PVPPDQ-------LEDMAERFHFVSSTSELHLMKME--------FLELKYRLLSLLVLAE 527
+ P++ L ++ E++ + SE L +++ FL+ S L +E
Sbjct: 2278 NLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSE 2337
Query: 528 SKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA 587
+L++ E++ LL+ SF E+ ++ + + + + + + S +E
Sbjct: 2338 KELENMHKGGSSPETLPSLLKRQGSFSED---VISHKGDLRFVTISGQKVLDMENSFKEG 2394
Query: 588 ENVMKFMN-------ETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAE 640
+ + N + T ++ L + + S L ++ + ++ N+ SLQAW++ E
Sbjct: 2395 KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACE 2454
Query: 641 KMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWREL 700
+ E D + P +Q+ A + +E+ + + L R
Sbjct: 2455 ANV---EKLLSDTVASDPGVLQEQLATTK------QLQEELAEHQVPVEKLQKVAR---D 2502
Query: 701 FMEVKQYAQADEMDRMKKEYTDCVV----TLSAFATEAHKKLSEPLEVSFM---NVKLLI 753
ME++ D R +E TD ++ +LS E L + + S +++ L+
Sbjct: 2503 IMEIEGEPAPDH--RHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLL 2560
Query: 754 QDLEDIEQRVP-----------VMDAQYKIITKTAHLITKESPQEEGKEMF--------- 793
Q + ++EQ + + +A + + ++S E +EM
Sbjct: 2561 QSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADS 2620
Query: 794 ATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLER--- 850
T + L+ +L +V + + L + Q+ L++L Q F GK+ + + R
Sbjct: 2621 TTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA 2680
Query: 851 ----EAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQ----- 901
Q F Q+ QEL E+ ++ L +E + ++ +H D+
Sbjct: 2681 SGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLR 2740
Query: 902 ---TRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFE---------ESRAELEKV 949
T LQ+ + + S ++ +++K V T + +K+ E S ELEK
Sbjct: 2741 KDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQ 2800
Query: 950 LRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAF------------------------ 985
+ + L++ L+ + L+ ++
Sbjct: 2801 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2860
Query: 986 LKACDELTDILPEQEQQGL--QEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKN-----RF 1038
C +LT+I + L ++ LH++ + LQ +L+ +V K ++
Sbjct: 2861 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQA-----ILNRMEEVHKEANSVLQW 2915
Query: 1039 LASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVR 1098
L S EE +D + E + + ++ F ++ + ++Q ++E L V
Sbjct: 2916 LESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQN---SPKIQKVKEALAGLLVT 2972
Query: 1099 DPVRDTPGTCHVTLKELRAAID-------STYRKLMEDPDKWKDYTSRFSEFSSWISTNE 1151
P +EL + + + R+L E + + S+ W+ E
Sbjct: 2973 YPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKE 3032
Query: 1152 TQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLK-VLT---EVS-SENE 1206
+ + +ID K+ V+ + R + L + +LT +VS S ++
Sbjct: 3033 LMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ 3092
Query: 1207 AQKQGDELAKLSSSFKALVTLLSEVEKMLSN-FGDCVQYKEIVKNSLEELISGSKEVQEQ 1265
QK EL ++ + L L+ + QY+E++++ E++ + + + Q
Sbjct: 3093 VQK---ELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ 3149
Query: 1266 AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQ---------GEGGLPDR 1316
+ + T+ QQL ++T I + + ++ +AQ GE L D
Sbjct: 3150 S--AISTQPEAVKQQL-----EETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDE 3202
Query: 1317 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
+ L + L GLE + R+Q L ++F+ + + +L S +
Sbjct: 3203 LKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPI 3262
Query: 1377 SS-LESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLG---PQNKQLLQQQAKSIKE 1432
S+ LE L S+L++ +EF K + E +V E + L + K+ LQ Q +K
Sbjct: 3263 SAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKN 3322
Query: 1433 QVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQ 1492
++L + ++ K + + E L WI + + +++ L + + ++ S
Sbjct: 3323 HWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSL 3382
Query: 1493 I--KVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL 1550
+ K + E+E + S + L A E I+ + I + + + E Q
Sbjct: 3383 LRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDG-IRDEKAGINQNMDAVTEELQAK 3441
Query: 1551 EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSA--TETYKVLQEHMDLCQA 1608
G++ + ++F+E+ + I++ V + +L + + S A + + L+ ++ QA
Sbjct: 3442 TGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQA 3501
Query: 1609 LESLSSAITAFS----ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLL--- 1661
LE + F+ A + + +A QQ++ ++ +R +EN L
Sbjct: 3502 LEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGI 3561
Query: 1662 AHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGE---LQLIQALQNEVVSQAS 1718
+ +E+ S L L+ + D + + ++E L I L+ ++ + +
Sbjct: 3562 GQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEA 3621
Query: 1719 FYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFD 1778
+L+ + +L + K +++ + +L ER + + + + ++ + + +
Sbjct: 3622 ECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLN 3681
Query: 1779 ELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLG 1838
+ + L + +E+ I++ Q+A + +K ++ LQ L ++
Sbjct: 3682 DATTAAEEAEAL---QWVVGTEVEIINQQLADFK--------MFQKEQVDPLQMKLQQVN 3730
Query: 1839 SLGRAEDLHLLQGKAEDC----------------FQLFEEASQVVERRQLALSHLAEFLQ 1882
LG+ L+Q +DC L ++ +Q + + Q AL H +F
Sbjct: 3731 GLGQG----LIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF-- 3784
Query: 1883 SHASLSGILRQLRQTVE--ATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKA 1940
+L +L L T E A E +++ + + + L+ ++D + ++
Sbjct: 3785 -QDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843
Query: 1941 QYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKS 2000
+ R + L + + +Q + + + VL K F + E +
Sbjct: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903
Query: 2001 IEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFA 2060
+ E++ +QQ++ LE+++ +H ++ +A +I Q +
Sbjct: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDV----HQAVKIGQSLSSLT 3959
Query: 2061 PEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM-----------REYQNLKSAVSKVL 2109
++ + L D + E Q +CC L+ + + + +++V
Sbjct: 3960 SPAEQGV--LSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
Query: 2110 ENASSVIVTRTTIKD--QEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2167
+ SSV V KD Q+ L + H ++ ++K++D G+ L LK+
Sbjct: 4018 DKLSSVFV-----KDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQAL---LKQTT 4069
Query: 2168 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2227
+ L++ ++ ++ D++ + + L + + ST +E+ GW + ++
Sbjct: 4070 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGW----LREV 4125
Query: 2228 AENISNLDNHLRAEELLKEF---ESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFI 2284
E ++ E + +F + E+K + + + VN++ L + +
Sbjct: 4126 EEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGL 4185
Query: 2285 EADLMQKLEHAKEITEVAKGTLKDFTA---QSTQVEKFINDITTWFTKVEESLM-----N 2336
+ + E K +++ + + A +S Q E+ + W + + LM
Sbjct: 4186 DKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIR 4245
Query: 2337 CAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKH 2396
Q++T L+ K ++ + ++ + + + + L LI+++
Sbjct: 4246 LEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQY 4305
Query: 2397 EAVSQLCSKTQASLQES--LEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLH 2454
EA+S L S+ A L+ + L F E+ +E W +A + D + L +
Sbjct: 4306 EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 4365
Query: 2455 DLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDK 2514
+++ + +S+++ + +D + + G L L+ + ++E+ KA + ++ +
Sbjct: 4366 EMRQLRESIAEHKPHIDKLLKIGPQL-KELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 4424
Query: 2515 QALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGEL 2574
AL + S+ + H K+ + + ENL + P EV K+ + +
Sbjct: 4425 LALDEAVSQSTQITEFHDKIEPMLETL------ENLSSRLRMPPLIPAEVDKIRECISDN 4478
Query: 2575 LAARESLDK-------LSQRGQLLSEEGHGAGQE------GRLCSQLLTSHQNLLRMTKE 2621
+A L+K L +RG+ L GA ++ Q++ +++ +E
Sbjct: 4479 KSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEE 4538
Query: 2622 KLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMK 2681
+ L+ E + ++ +K QD + ES G ++ K+ + + + +
Sbjct: 4539 REIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESP-GIDPSIIKQQVEAAETIKEE 4597
Query: 2682 GEG-EVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVIS 2740
+G +L G + + + + ++ ++ + W ++ + LE +
Sbjct: 4598 TDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQ 4657
Query: 2741 QWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRL 2800
Y + + W+++ K+ L L+ ++ E + +L
Sbjct: 4658 AAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKL 4717
Query: 2801 IAKSRELYEKTEDESFKDTAQE---ELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVH 2857
+ + +K DE+ +D +E ELK + ++ + K+E + + A+
Sbjct: 4718 NHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALE 4777
Query: 2858 EFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQN 2917
E WL +E L +SGD + +L+K L + + + V E+ ++
Sbjct: 4778 ELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLES 4837
Query: 2918 TTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALE 2977
+ + + ++A+ W+ + + L++ + Q E + +L +
Sbjct: 4838 SAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMES 4897
Query: 2978 QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFS 3037
Q SA T T E +T E L + KA+ T + L S
Sbjct: 4898 QLSASKPTGGLPETAREQLDTHME-----------LYSQLKAKEETYNQLLDKGRLMLLS 4946
Query: 3038 RDLSTYSGK----VSGLIKEYNCLCLQASKGCQNKEQILQ--QRFRKAFRDFQQWLVNAK 3091
RD S K V+ L ++++ + + + E+ L F+ + ++F WL A+
Sbjct: 4947 RDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAE 5006
Query: 3092 ITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQ 3151
+ ++ V + +++ + F +E + ++ + G L L K+ I+
Sbjct: 5007 QSLNIASPPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIK 5066
Query: 3152 AKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEK------MVHE 3205
+ + + W+ ++ +L++ + + K F + + + DWL E +
Sbjct: 5067 NLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISN 5126
Query: 3206 SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLS 3265
+++ +K +E QK + ++ + R ++ L E +F + ++
Sbjct: 5127 DPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF---LGEVR 5183
Query: 3266 SQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHML--DSYCHPTSDKSVL 3323
++ + + E+ +L+ + QF ++ L DW+ L D H D L
Sbjct: 5184 DKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD---L 5240
Query: 3324 DSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSA 3383
+ + + K ++ R L S + ++ QLQ + W ++
Sbjct: 5241 VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKL 5300
Query: 3384 GIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3419
+ +S+LE AL + ++D V W+ E L
Sbjct: 5301 SVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTL 5336
Score = 198 bits (504), Expect = 2e-49
Identities = 695/3845 (18%), Positives = 1469/3845 (38%), Gaps = 549/3845 (14%)
Query: 3443 NEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVT-KSEKLVRLH 3501
+E+++SY SLL IE++ + + ELQDL + + ++ K+ T S++L ++
Sbjct: 1807 DEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVN 1866
Query: 3502 QEYQRDLKAFEVWLGQEQEKLDQ-YSVLEGDAHTHETTLRDLQELQVHCAEGQALLN--S 3558
Q + + Q QE Q LE DA + +L + + LL+ +
Sbjct: 1867 Q----------IIISQPQEVPAQLLKALEKDAKNLQKSLSSVSD-----TWNSRLLHFQN 1911
Query: 3559 VLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNV-VNKLRLMEQKFQQV 3617
+ + + + Q E R L+ LR W ++ + ++ + + V+ L L QQ
Sbjct: 1912 AVEIEKTKVLNQHTQLEGR-LQDLRA-WVGNKNLILNSKGSNSEIDVDSLNLC---LQQY 1966
Query: 3618 DEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQ 3677
++ + E+K + A+ D + AQ++ + N +M +L +Q +L Q
Sbjct: 1967 EDLKQPMAERKAQLDALAF-DIQFFISEHAQDLSPQQ--NRQMLRLLNELQRSFQDILEQ 2023
Query: 3678 VLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEV 3737
Q+ L+ +Q +E+ E+ + + + H+ +++ + + + + + G + +T +
Sbjct: 2024 TAAQVDALQGHLQQMEQ-EALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQ 2082
Query: 3738 LLKDMEKGHSLLKSAREK-GERAVKY-----------------LEEGEAERLRKEIHDHM 3779
L ++K S LK ++ RA + L E LR+++H
Sbjct: 2083 DLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAK 2142
Query: 3780 EQLKELTSTVRKEHMTLEKGL-----------HLAKEFSD---KCKALTQWIAE------ 3819
EQ + L R LE+ + AKE ++ K AL W+
Sbjct: 2143 EQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGG 2202
Query: 3820 ---------------------------YQEILHVPEEPKMELYEKKAQLSKYKSLQQTVL 3852
Y + PE+ + KA+ + S QQ +
Sbjct: 2203 QLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFI 2262
Query: 3853 SHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNN- 3911
S ++ ++ L + L+ K+ +L+ Y + +A ++++ +D L
Sbjct: 2263 LATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKF 2322
Query: 3912 ---------------------------------------------LQMKGD----TLIGQ 3922
+ KGD T+ GQ
Sbjct: 2323 LQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ 2382
Query: 3923 CADHLQAKLKQN---------VHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDT 3973
++ K+ V L+ + Y+A+ S R+ L L ++ Q++
Sbjct: 2383 KVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 2442
Query: 3974 LQQCQAWLSAVQPDLEPSPQPPLSRAEAI--KQVKHFRALQEQARTYLDLLCSMCDLSNA 4031
QAW+ A + ++E ++ + +Q+ + LQE+ + + + ++
Sbjct: 2443 ADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD 2502
Query: 4032 SVK---TTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRR 4088
++ A D + ++T + L Q+L+ E L + Q + L+++ +
Sbjct: 2503 IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQS 2562
Query: 4089 HSELELNIAQNMVSQVKDFV--------KKLQSKQASVNTIIEKVNKL-TKKEESPEHKE 4139
E+E N+ VS + V KL+ A + +E ++ T+ E+ +
Sbjct: 2563 IGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTT 2622
Query: 4140 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4199
L + ++ ++ LCLQ++E + + E K +N +R A
Sbjct: 2623 AAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG 2682
Query: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD--------DKELVKEQTSHLE 4251
+ + +QE +ED + + +EHL + D +++ +L
Sbjct: 2683 NQPD-QDITHFFQQIQELNLEMED-QQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLR 2740
Query: 4252 QRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQN 4311
+ + +L+ +K + + + + E+L+ + + +W +E + +I ++ +
Sbjct: 2741 KDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQ 2800
Query: 4312 L-----LMDHLA----ICSELEAKQMLLKSLIKD---------ADRVMADLGLNERQVIQ 4353
+ L+D A + E+ K L++LI + ++ +G + V
Sbjct: 2801 IEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNG 2860
Query: 4354 KALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIM----FRE 4409
+ + C V + + L L E+ + L A+ ++ + ++ +E
Sbjct: 2861 YHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKE 2920
Query: 4410 HICLLPDDVSKQVKT---------CKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSE 4460
+ D +S KT K+ A L+ ++ + L+ +++E
Sbjct: 2921 EVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAE 2980
Query: 4461 VLGKLQ-ELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEIN 4519
K+Q EL S ++ + R ++LE++ F+ + WL + +++
Sbjct: 2981 NWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGP 3040
Query: 4520 LMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEV--DHSYLSEKLNAL 4577
L + + L+ Q + Q +L++ L Q IL +V S + ++L ++
Sbjct: 3041 LSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSI 3100
Query: 4578 PRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEE 4637
+++ + + ++ +AI+ +Y L+ Q LSE ++ V L+V+
Sbjct: 3101 NQKWVELTDKLNSRSSQIDQAIVKSTQYQELL----QDLSE------KVRAVGQRLSVQS 3150
Query: 4638 ALSLQ-DGCRAILDEVAGLGEAVDELNQKKEGFRS--------TGQPWQPD---KMLHLV 4685
A+S Q + + L+E + + +++L+ + + ++ G+ + D K L V
Sbjct: 3151 AISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 3210
Query: 4686 TL-YHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSK---VNEETLPAE 4741
L L+ R++ L+ ++ Q+ ++M +L L + +Q+K ++ + +
Sbjct: 3211 ALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQ 3270
Query: 4742 EKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAI 4801
+L+ SL + + E L + P + + +Q+ ELK +
Sbjct: 3271 SQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPP---GEEKRTLQNQLVELKNHWEEL 3327
Query: 4802 GETVTECESR----MVQSIDFQTEMSRSLDWLRRVKAELS------GPVYLDLNLQDIQE 4851
+ + +SR M ++ +Q + + W+ KA++S PV L+ +L +
Sbjct: 3328 SKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKA 3387
Query: 4852 EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALR 4911
+ ++ E+ +S L I+N+ + + + E + A +++ + E L+
Sbjct: 3388 MLNEV----EKRRSLLEILNSAA----DILINSSEADEDGIRDEKAGINQNMDAVTEELQ 3439
Query: 4912 TRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE 4971
+ +L E+ + + + + F+ +E A+ L++ D ++ ++E +
Sbjct: 3440 AKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEI----FDALGSQACSNKNLEKLRAQ 3495
Query: 4972 DQFHSNLE-ELHSLVATLDPLIK--PTGKEDL----EQKVASLELRSQRMSRDSGAQVDL 5024
+ LE ++ L L++ P G + + +VA E + +SG +
Sbjct: 3496 QEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCV--M 3553
Query: 5025 LQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSF 5084
++ + E+ + D + +L + + + ++ + + ++ ++
Sbjct: 3554 MENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTD-SLQSQIEDVRLFLNKIHVL 3612
Query: 5085 HEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTG 5144
I A E + + + L R + + ++ +L + +++ LE +
Sbjct: 3613 KLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLELTLGRVED 3672
Query: 5145 FNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQT 5204
F K+K + ++ + + E+ + + F + ++Q L M QQ
Sbjct: 3673 FYRKLKGLNDATTAAEE---AEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQ- 3728
Query: 5205 LSMLQDGAAPTPGEEPPL------MQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVE 5258
++ L G + G++ + M+EI A R + +KV +++ L +
Sbjct: 3729 VNGLGQGLIQSAGKDCDVQGLEHDMEEINA---RWNTLNKKVAQRIAQLQEALLHCGKFQ 3785
Query: 5259 TQINSVKCWVQETKEYLGN---PTIE---IDAQLEELQILLTEATNHRQNIEKMAEE--- 5309
+ + W+ +T+E + N P+ E + AQ++E ++L + + ++ + E
Sbjct: 3786 DALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGR 3845
Query: 5310 --------QKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSR 5361
+EK G L S + L++ A K Q++D + +Q T++ +S
Sbjct: 3846 IAQSAELADREKITGQLESLESRWTELLSKAAARQK---QLEDILVLAKQFHETAEPISD 3902
Query: 5362 QIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQ 5421
+ K L + +T + Q K L E+++ + ++ AV K +
Sbjct: 3903 FLSVTEKKLAN-SEPVGTQTAKIQQQIIRHKALEEDIE---NHATDVHQAV-KIGQSLSS 3957
Query: 5422 LGKP-----LAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKA 5475
L P L++KI L + + + + + L+QA S+ + E +L W+ E
Sbjct: 3958 LTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE 4017
Query: 5476 KVLAHGTIAWNSASQLREQYILHQTLLEE----SKEIDSELEAMTEKLQYLTSVYCTEKM 5531
L+ + L Q+ H L EE K +D ++ L+ T +
Sbjct: 4018 DKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVL-LI 4076
Query: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR 5591
+++ + ++ L+ L+ A + KF++ ++L L + + L + G+
Sbjct: 4077 QEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELAT-SGGQ 4135
Query: 5592 LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRL------- 5644
EQ+ Q + LK +V +L + + L A L
Sbjct: 4136 SPTGEQIPQFQ---QRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDA 4192
Query: 5645 QEEASRLQHTAIQQCNIMQAAVVQYEQYEQ----------EMKHLQQLIEGAHREIEDKP 5694
E+ + T Q+ + + AA+ + +QYEQ E K + + G R +D+
Sbjct: 4193 NEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKR-KLMALGPIRLEQDQT 4251
Query: 5695 VATSNIQE-LQAQISRHEELAQKIKGY---------QEQIASLNSKCKMLTMKAKHATML 5744
A +Q+ I RH++ ++ + +EQ L K + L + + ++L
Sbjct: 4252 TAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLL 4311
Query: 5745 -------------------LTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTL 5785
T E+ E T L + LP+P+ + L
Sbjct: 4312 NSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQ-LPSPAIDHEQLRQQQEEMRQL 4370
Query: 5786 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5845
+ E +I +P + + Y + E Q A
Sbjct: 4371 RESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEA 4430
Query: 5846 STSASQ--EFY---EPGLE------------PSATAKLGDLQRSWETLKN--VISEKQRT 5886
+ ++Q EF+ EP LE P A++ ++ K+ V EK +
Sbjct: 4431 VSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQP 4490
Query: 5887 LYEALERQ-----------------QKYQDSL-------QSISTKMEAIELKLSESPEPG 5922
+EAL+R+ ++ QD L + I + E E+K + E
Sbjct: 4491 SFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELA 4550
Query: 5923 RSPESQMAEHQALMDEILMLQDEINELQS-SLAEELVSESCEADPAEQLALQSTLTVLAE 5981
MA AL+ I QD +++L+S + ++ + EA AE ++ L E
Sbjct: 4551 EKFWYDMA---ALLTTIKDTQDIVHDLESPGIDPSIIKQQVEA--AE--TIKEETDGLHE 4603
Query: 5982 RMSTIRMK------ASGKRQLLE------------EKLNDQLEEQRQE-----QALQRYR 6018
+ IR+ A G+ + E E LN +E+ ++ QA +Y+
Sbjct: 4604 ELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQ 4663
Query: 6019 CEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNEN 6078
+ WL +T L T + ++ QL + + VE+ Q+ + + +L+ H
Sbjct: 4664 DTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLN-HQGE 4722
Query: 6079 LLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQS 6138
L+L+ KA + + + + L LK L + +Q ++G + L S
Sbjct: 4723 LMLK-KATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4781
Query: 6139 PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSG 6198
WL QR S K +E ELA+ L ++L + ET
Sbjct: 4782 -----WLTHTEELLDAQRPIS-GDPKVIEVELAKHHVL-------KNDVLAHQATVETVN 4828
Query: 6199 DAGEKPDVLSQELGMEGEK-SSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSR 6257
AG ++L G + S + M WES+ Q+ +++ LQ+ L+Q Q +S
Sbjct: 4829 KAGN--ELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQG--FHSE 4884
Query: 6258 PNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG---AKRQSIHLEQKLYD 6314
L + T+ +S +++ S +GG R+ + +LY
Sbjct: 4885 IEDFLLEL--------TRMESQLSA------------SKPTGGLPETAREQLDTHMELYS 4924
Query: 6315 GVSATSTWLDDVEERLFVATALLPEETETCLFNQ---EILAKDIKEMSEEMDKNKNLFSQ 6371
+ A EET L ++ +L++D + +++ L Q
Sbjct: 4925 QLKA-------------------KEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ 4965
Query: 6372 AFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLAD 6431
+ + R S L+ +N + + LQ+ +N+ + +
Sbjct: 4966 KWHVVSSKME----------ERKSKLEEALN-LATEFQNSLQEFINWLTLAEQSLNIASP 5014
Query: 6432 NKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS 6490
I+ L+ + E V A ++ A D + E D +LK K V L
Sbjct: 5015 PSLILNTVLSQIEEHKVFANEVNA---HRDQIIELDQTGNQLKFLSQKQDVVL-IKNLLV 5070
Query: 6491 KLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE 6550
+Q +++++ R L+ Q+ A + L D LE + + + + I + +
Sbjct: 5071 SVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELE-ISNDPD 5129
Query: 6551 EIQQLLDKHKEYFQGLESHMILTETLFR--------KIISFAVQKETQFHTELMAQASAV 6602
+I+ L KHKE+ + L + +T R ++ QK F E+ + V
Sbjct: 5130 KIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTV 5189
Query: 6603 LKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQ 6662
++ +R +LE L + Q L L VE + V + D +++ + ++
Sbjct: 5190 CGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHK 5249
Query: 6663 HLKSSLNEYQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRL 6719
+ L + + QVL R LI S D ++ QL +L W + + RL
Sbjct: 5250 VFQKELGK-RTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRL 5308
Query: 6720 ETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVD 6779
E LK ++ L+ WL A+ L F +P + E ++ ++ EF K+V+
Sbjct: 5309 EQALKQAEVFRDTVHMLLEWLSEAEQTLRF----RGALPDDTEALQSLIDTHKEFMKKVE 5364
Query: 6780 AQSSLKSSVLSTGNQLLRLKKVD-TATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDK 6838
+ +S ++ G +L + D T++ ++ I +++ ++LT Q++L +
Sbjct: 5365 EKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSEL 5424
Query: 6839 LPSRHAISEVMSWISLME-NVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVD 6897
+ + + E+++WI E +IQ+D++ I +I + + +++ F ++ KQ VD
Sbjct: 5425 VANAELLEELLAWIQWAETTLIQRDQEPIPQNI--DRVKALIAEHQTFMEEMTRKQPDVD 5482
Query: 6898 FVNQS 6902
V ++
Sbjct: 5483 RVTKT 5487
Score = 159 bits (402), Expect = 1e-37
Identities = 466/2679 (17%), Positives = 1020/2679 (38%), Gaps = 316/2679 (11%)
Query: 313 ANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQI 372
ANSV + + K M + + +AQ ESN K F + E +I
Sbjct: 2909 ANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQ-AESN--------KAFLAELEQNSPKI 2959
Query: 373 EHLIQPL----------HRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKS------LPA 416
+ + + L Q + W+R T QL++S A
Sbjct: 2960 QKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQA 3019
Query: 417 PLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRT 476
+ WL E+ + V N + + +Q + +L+ +A ++ ++
Sbjct: 3020 AESQLRPWLMEKELMMG----VLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQL--N 3073
Query: 477 RSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIK 536
+ GI P + + EL + +++EL +L S S++ I+K
Sbjct: 3074 EAAQGILTGPGDVSLSTSQVQ-----KELQSINQKWVELTDKLNS----RSSQIDQAIVK 3124
Query: 537 YGRRESVEQLLQNYVSFIEN-----SKFFEQYEVTYQILKQTAEM---YVKADGSVEEAE 588
+ + + Q L V + S Q E Q L++T+E+ + D V+EA+
Sbjct: 3125 STQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQ 3184
Query: 589 NVMKFMN----------ETTAQWRNLSVEVRSVRSM-------LEEVISNWDRYGNTVAS 631
+ ++ E + +++ ++ + + L+ +++ ++
Sbjct: 3185 TLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDE 3244
Query: 632 LQAWLEDAEKM-------------LNQSENAKKDFFRNL-PHWIQQHTAMNDAGNFLIET 677
L+ WL+D + L ++F ++L H + + + L+
Sbjct: 3245 LRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSV 3304
Query: 678 CDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMK------KEYTDCVVTLSAFA 731
R L+ QL+ L W EL + AD R+K ++Y V L +
Sbjct: 3305 PPGEEKRTLQNQLVELKNHWEELSKKT-----ADRQSRLKDCMQKAQKYQWHVEDLVPWI 3359
Query: 732 TEAHKKLSE--------PLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKE 783
+ K+SE LE S + K ++ ++E + ++++ I LI
Sbjct: 3360 EDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI------LINSS 3413
Query: 784 SPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINE 843
E+G ++++ + + + E Q LEE+ +++ F +S I +
Sbjct: 3414 EADEDG---------IRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEK 3464
Query: 844 IITVLERE-----AQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVT--LSNVL 896
+ + + A S K+ E L Q+ + L +E ++ F + +
Sbjct: 3465 KVEGAKHQLEIFDALGSQACSNKNLEKLRAQQ---EVLQALEPQVDYLRNFTQGLVEDAP 3521
Query: 897 KHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEG 956
D ++L Q F + ++ +E + +F E+ L +
Sbjct: 3522 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDE 3581
Query: 957 LEEKG----DPEELLRRHTEFFSQLDQ-RVLNAFLKACD-ELTDILPEQ---EQQGLQEA 1007
L+ G D + L + + L++ VL ++A + E +L E+ + GL+
Sbjct: 3582 LDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRE 3641
Query: 1008 VRKLHKQWKDL--QGEAPYHLLHLKIDVEKN--RFLASVEECRTELDRETKLMPQEGSE- 1062
+ L+KQ L +G+A L L + ++ R L + + T + L G+E
Sbjct: 3642 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3701
Query: 1063 KIIKEHRVFFS--DKGPHHLCEKRLQLIEEL---CVKLPVRDPVRDTPGTCHVTLKELRA 1117
+II + F K + +LQ + L ++ +D D G H ++E+ A
Sbjct: 3702 EIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDC--DVQGLEH-DMEEINA 3758
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFS-------SWISTNETQLKGIKGEAIDTANHGEV 1170
++ +K+ + + ++ +F SW++ E + K + A + V
Sbjct: 3759 RWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPS---AEYKVV 3815
Query: 1171 KRAVEE---IRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTL 1227
K ++E ++ + R T+ L++ + + + + +K +L L S + L++
Sbjct: 3816 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3875
Query: 1228 LSEVEKMLSN-------FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQ 1280
+ +K L + F + + + E+ ++ S+ V Q KI QQ
Sbjct: 3876 AAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKI---------QQ 3926
Query: 1281 LLLHHQQKTKRISAKKRDVQQ--QIAQAQQGEGGLPDRG--HEELRKLESTLDGLERSRE 1336
++ H+ + I DV Q +I Q+ ++G E++ L++ ++
Sbjct: 3927 QIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC 3986
Query: 1337 RQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSEL--EQTKEFSK 1394
R+ + L F ++ V+ +L + E LS ++ ++ Q +
Sbjct: 3987 RKAALLDQALSNARLFGEDEVEVLNWLAEV----EDKLSSVFVKDFKQDVLHRQHADHLA 4042
Query: 1395 RTESIAVQAENL---VKEASEIPLGPQNKQ--LLQQQAKSIKEQVKKLEDTLEEDIKTME 1449
E I + +N+ +K + ++ L+Q++ IK + + T + ++T+E
Sbjct: 4043 LNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLE 4102
Query: 1450 MVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS--- 1506
+ F S +E L+ W+ E E+EL A S QI Q + +E++ ++
Sbjct: 4103 QARQLATKFQSTYEELTGWLREVEEEL-ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRL 4161
Query: 1507 -IVGLEEEAQSFAQFV----TTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQ 1561
+ + E +++ + V G + Q + + + + ++ I +
Sbjct: 4162 VLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAI----QRS 4217
Query: 1562 QKFEENLRKIQQSVSEFEDKLAV--PIKICSSATETYKVLQE--------HMDLCQALES 1611
Q++E+ V+E + KL PI++ T +Q+ H D L S
Sbjct: 4218 QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFS 4277
Query: 1612 LSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKEL 1671
S I +K V + ++ +L QQYE I ER LE + +
Sbjct: 4278 HRSEIFGTCGEEQKTVLQ----EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETY 4333
Query: 1672 SSFLTWLERGEAKASSPEMDISA-DRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
W+E E +A ++ A D ++ + + ++ L+ + KLL++ L
Sbjct: 4334 EELSPWIE--ETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQL 4391
Query: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1790
+ + ++ +M++ ++ + + + + + +R L V++ Q E F I+
Sbjct: 4392 KEL-NPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITE----FHDKIEP 4446
Query: 1791 FLSELQTTSEISIMDHQV---------ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG 1841
L L+ S M + ++ +K E+E + ++L+ +L
Sbjct: 4447 MLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRS 4506
Query: 1842 RAEDLHL----LQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSH-ASLSGILRQLRQ 1896
+ D L +Q K + +E+ E R++ + E + ++ +L ++
Sbjct: 4507 QGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKD 4566
Query: 1897 TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGS-------S 1949
T + + + ES I+ + Q +A E+ DG+ + ++ +G+
Sbjct: 4567 TQDIVHDL---ESPGIDPSI--IKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGE 4621
Query: 1950 EQRTSCRATADQLCGE--------VERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSI 2001
++ R + D++ ER++ L Q+ L+ F ++K
Sbjct: 4622 TEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLC 4681
Query: 2002 EDIEERTDKERLKEPTRQALQQRLRVF-NQLEDELNSHEHELCWLKDKAKQIAQKDVAFA 2060
TD +K+ + + ++ V+ Q+E E +H+ EL + KA +D+
Sbjct: 4682 TMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGEL--MLKKATDETDRDIIRE 4739
Query: 2061 PEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRT 2120
P + L+ W++ I Q + G + + ++Q+ + L + ++ +
Sbjct: 4740 P-----LTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQR 4794
Query: 2121 TIK-DQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDME 2179
I D + ++ +KH KN + Q ++ G L L+ D S +++ +E
Sbjct: 4795 PISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNEL---LESSAGDDASSLRSRLE 4851
Query: 2180 STVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLR 2239
+ W V +K EE +L+ ST + +G+ + + E ++ +++ L
Sbjct: 4852 AMNQCWESVLQKTEEREQQLQ----------STLQQAQGFHSEIEDFLLE-LTRMESQLS 4900
Query: 2240 AEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEAD------------ 2287
A + + + EL+S++ +E L L + D
Sbjct: 4901 ASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSV 4960
Query: 2288 --LMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQ------ 2339
L QK E K L++ +T+ + + + W T E+SL N A
Sbjct: 4961 ALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSL-NIASPPSLIL 5019
Query: 2340 NETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAV 2399
N +++ K E+ + + I + N L ++ + + + + E V
Sbjct: 5020 NTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKV 5079
Query: 2400 SQLCSKTQASLQESLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQ 2457
Q + SL ++ + K F E+ ++ +W A++ + + D ++ +L +
Sbjct: 5080 VQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHK 5139
Query: 2458 NILDSVSDGQSKLDAVTQEGQTLYAH-LSKQIVSSIQEQITKANEEFQAFLKQCLKDKQA 2516
++ Q D + G+ L L + + + + +++ + ++ +
Sbjct: 5140 EFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199
Query: 2517 LQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLA 2576
L++ G F D + L W++++E + + + + HKV F EL
Sbjct: 5200 LEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKV--FQKELGK 5257
Query: 2577 ARESLDKLSQRGQLLSEEGHG--AGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHE 2634
++ L + G+ L E +G+L +L T + +++ K + AL++ E
Sbjct: 5258 RTGTVQVLKRSGRELIENSRDDTTWVKGQL-QELSTRWDTVCKLSVSKQSRLEQALKQAE 5316
Query: 2635 ALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGK 2694
+ + + W+ + L + + L+ + ++ + E V +N A+
Sbjct: 5317 VFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAM 5376
Query: 2695 GEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQ 2754
GE L + + I+ + ++ + ++++ + Q LE+ +S+ E +L
Sbjct: 5377 GEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLA 5436
Query: 2755 WME----SVDQKIEHPLQPQPGLKEKFVLLDHLQSILSE 2789
W++ ++ Q+ + P+ PQ + K ++ +H Q+ + E
Sbjct: 5437 WIQWAETTLIQRDQEPI-PQNIDRVKALIAEH-QTFMEE 5473
Score = 146 bits (369), Expect = 8e-34
Identities = 417/2292 (18%), Positives = 875/2292 (38%), Gaps = 307/2292 (13%)
Query: 6521 ERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMI-LTETLFRK 6579
ER L+DL L+ QE +Q II +E QLL ++ + L+ + +++T +
Sbjct: 1848 ERELKDLTTLVS--QELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSR 1905
Query: 6580 IISF--AVQ----KETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQ 6633
++ F AV+ K HT+L + + + + L S+ + D L+
Sbjct: 1906 LLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILN---SKGSNSEIDVDSLNLC 1962
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLY--QHLKSSLNEYQPKLYQVLDDGKRLLISISC 6691
L+ E + + D L I + +H + + ++ ++L++ +R S
Sbjct: 1963 LQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQR-----SF 2017
Query: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751
D+ Q + + +M +E ++T+ K + DL W+ A+ L
Sbjct: 2018 QDILEQTAAQVDALQGHLQQMEQEA-LVKTLQKQQNTCHQQLEDLCSWVGQAERALA--G 2074
Query: 6752 QQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL-----RLKKVDTATL 6806
Q T Q+L ++ + + + ++ +++ ++V+ + +L + L
Sbjct: 2075 HQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTAL 2134
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQ-----LQMDKLPSRHA---------ISEVMSWI 6852
R +L + Q+ L Q++L + LQ + S+ A I ++ W+
Sbjct: 2135 REKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWV 2194
Query: 6853 S--------LMENV--------IQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTV 6896
+ L+ N+ ++ + + GY +++ +K +D C+ +
Sbjct: 2195 TSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEK-----LDKQCEMMKA 2249
Query: 6897 DFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEY 6956
+Q +L + + +S + F +Q G L E+ Q+L+ L E
Sbjct: 2250 R--HQELLSQQQNFILATQSAQA-FLDQHG---------HNLTPEEQQMLQQKLGELKEQ 2297
Query: 6957 ENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLA 7016
+ T E LKQ + D+ +Q L+D ++ E ++ EKE+E + + G +
Sbjct: 2298 YS------TSLAQSEAELKQVQTLQDE--LQKFLQDHKEFESWLERSEKELENMHKGGSS 2349
Query: 7017 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLM 7076
+ S L+ G S + SHK
Sbjct: 2350 ---------PETLPSLLKRQG------------------SFSEDVISHK----------- 2371
Query: 7077 EARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTE 7136
G L V + + ++++ K+ + + G++ LK+ T
Sbjct: 2372 -------------GDLRFVTISGQKVLDMENSF-KEGKEPSEIGNLVKDKLKDATERYT- 2416
Query: 7137 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLK 7196
L + + N LL + Q Q+S LQ W + C + V++ T
Sbjct: 2417 ALHSKCTRLGSHLNMLLGQY-HQFQNSADSLQAWMQ------ACEANVEKLLSDT----- 2464
Query: 7197 AATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQL 7256
A++ + +++AT Q +L + V+ ++ E + A +Q
Sbjct: 2465 VASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEI--EGEPAPDHRHVQETTD 2522
Query: 7257 SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLS 7316
S+ H +L +L ++ + LQ + ++ +SLE+L I E E+ L+G+ S S
Sbjct: 2523 SILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSS-G 2581
Query: 7317 TIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIK------RMQNLNRHWSLIS 7370
IQE + + L+ E+ R ++ +++ + +
Sbjct: 2582 VIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLC 2641
Query: 7371 SQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ-----HLLEQQRA 7425
Q E+ S L+ L Q + F +F+ + LA SGN H +Q +
Sbjct: 2642 LQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLA---SGNQPDQDITHFFQQIQE 2698
Query: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRG 7485
L EM +Q+ L ++ L G D + ++ L + + + ++R
Sbjct: 2699 LNL---EMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREK 2755
Query: 7486 IIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIP------------LQQARTLF 7533
S Q +R++ +KWL E GS+P ++ ++L
Sbjct: 2756 DASSCQEQLDEFRKLVRTFQKWLKETE-------GSIPPTETSMSAKELEKQIEHLKSLL 2808
Query: 7534 DEVQFK----EKVFLRQQGSYILTVEA------GK--QLLLSADSGAEAA---------- 7571
D+ K E++ + L +E GK +L S S +
Sbjct: 2809 DDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLT 2868
Query: 7572 -LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP 7630
+Q +++++ K++ L E+++ L +L E+ K L+ L + K+++ +S+
Sbjct: 2869 EIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLES-KEEVLKSMD 2927
Query: 7631 DHHEELHAEQMRCKELENA--VGSWTDDLTQLSLLKDTLSA----YISADDISILNERVE 7684
E ++ + N + + ++ +K+ L+ Y ++ + + E
Sbjct: 2928 AMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQE 2987
Query: 7685 LLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIE-EM 7743
L +WE R++Q+ E + A F +L WL + E + G + I+ M
Sbjct: 2988 ELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNM 3047
Query: 7744 IEKLKKDYQEEIAIAQENKIQLQQMGERL-----AKASHESKASEIEYKLGKVNDRWQHL 7798
+ K+ Q + + + Q +Q+ E S+++ +L +N +W L
Sbjct: 3048 LNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVEL 3107
Query: 7799 LDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQ 7858
D + +R ++ + +V Q + + L + + L+ S E ++++L E
Sbjct: 3108 TDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAI-STQPEAVKQQLEET 3166
Query: 7859 QELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSME 7918
E++ D+E+ V LC+ L D +++ + + + ++ +
Sbjct: 3167 SEIRSDLEQLDHEVKEAQTLCDEL---SVLIGEQYLKDELKKRLETVALPLQGLEDLAAD 3223
Query: 7919 RRLKIEETWRLWQKFLDDYSRFEDWL--KSSERTAAFPSSSGVIYTVAKEELKKFEAFQR 7976
R +++ Q+F + WL K S++ P S+ + + +L++ E FQ+
Sbjct: 3224 RINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKL--ERLQSQLQENEEFQK 3281
Query: 7977 QVHECLTQLELINKQYRRL------ARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILR 8030
+++ E+I + L E RT L+ + E W+ L K+
Sbjct: 3282 SLNQHSGSYEVIVAEGESLLLSVPPGEEKRT-----LQNQLVELKNHWEELSKKTADRQS 3336
Query: 8031 RLKHFIGQREEFETARDSILVWLTEMDLQLTNIE-HFSECDVQAKIKQLKAFQQEISLNH 8089
RLK + + ++++ + ++ W+ + +++ + +++ + + KA E+
Sbjct: 3337 RLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRR 3396
Query: 8090 NKIEQIIAQGEQLIEKSEPLDAAI------IEEELDELRRYCQEVFGRVERYHKKLIRLP 8143
+ +E + + + LI SE + I I + +D + Q G +E ++L
Sbjct: 3397 SLLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRL---- 3452
Query: 8144 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8203
E S + +E + A L D L Q SN +L + LR+++
Sbjct: 3453 ---REFQESFKNIEKKVEGAKHQLEIFDA-----LGSQACSNKNL---EKLRAQQEVLQA 3501
Query: 8204 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM-IPESP 8262
LE DY + ++ L + +G D + V + + + +
Sbjct: 3502 --------LEPQVDYLRN------FTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRV 3547
Query: 8263 EAYVKLTENAIKNTSGDHSALESQIRQLGKALD--DSRFQIQQTENIIRSKTPTGPELDT 8320
+ + EN ++ H + QL D D I + + ++S+ L
Sbjct: 3548 NSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDGMGAIGRDTDSLQSQIED-VRLFL 3606
Query: 8321 SYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQA 8380
+ +KL E S + H L+EE G ++L + + + + L +
Sbjct: 3607 NKIHVLKLDIEASEA-----ECRHMLEEE-----GTLDLLGLKRELEALNKQCGKLTERG 3656
Query: 8381 LSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLK 8438
+++ +++ L + + F L L D E+ + L+ + T+++ I Q+ K
Sbjct: 3657 KARQEQLELTLGRVEDFYRKLKG----LNDATTAAEEAEALQWVVGTEVEIINQQLADFK 3712
Query: 8439 ELQKA-VDHRKAIILSINLCSPEFTQADSKES--RDLQDRLSQMNGRWDRVCSLLEEWRG 8495
QK VD + + +N Q+ K+ + L+ + ++N RW+ + + +
Sbjct: 3713 MFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIA 3772
Query: 8496 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 8555
LQ+AL+ C F + LL L + + P + Q ++L+Q L
Sbjct: 3773 QLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQ--RLLD 3830
Query: 8556 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVS 8615
+ + V LQ ++ +AE D + ++ + +R LL + + K+LE +L ++
Sbjct: 3831 DRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLA 3890
Query: 8616 ----SSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSPHSRS 8671
+ + +S + S E + S P ++ +Q+ R K + H
Sbjct: 3891 KQFHETAEPISDFLSVTEKKLANS-EPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAV 3949
Query: 8672 TKGGSDSSLSEP 8683
G S SSL+ P
Sbjct: 3950 KIGQSLSSLTSP 3961
Score = 143 bits (361), Expect = 7e-33
Identities = 377/2142 (17%), Positives = 819/2142 (38%), Gaps = 260/2142 (12%)
Query: 540 RESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTA 599
R + L+++ + S+ Q EV Q + E+ + + EN ++ + +
Sbjct: 3510 RNFTQGLVEDAPDGSDASQLLHQAEVAQQ---EFLEVKQRVNSGCVMMENKLEGIGQFHC 3566
Query: 600 QWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRN--- 656
+ R E+ S + L++ + G SLQ+ +ED LN+ K D +
Sbjct: 3567 RVR----EMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAE 3622
Query: 657 LPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRM 716
H +++ ++ G LK++L LN + +L K A+ ++++
Sbjct: 3623 CRHMLEEEGTLDLLG--------------LKRELEALNKQCGKLTERGK--ARQEQLELT 3666
Query: 717 KKEYTDCVVTLSAF--ATEAHKKLSEPLEVSFMNVKLLIQDLEDIE--QRVPVMDAQYKI 772
D L AT A ++ V V+++ Q L D + Q+ V Q K+
Sbjct: 3667 LGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKL 3726
Query: 773 ITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMT 832
+ + + + Q GK+ + L+ + ++ ++ L + Q + L+E
Sbjct: 3727 --QQVNGLGQGLIQSAGKD--CDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCG 3782
Query: 833 SFYDSLGKINEIIT----VLEREAQSSALFK------QKHQELLACQENCKKTLTLIEKG 882
F D+L + + ++ + SA +K Q+ + L ++ K T+ +++
Sbjct: 3783 KFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAE 3842
Query: 883 SQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEES 942
+ + L+ D+ ++ Q+ + + ++ K +K +E L K+F E+
Sbjct: 3843 GGRIAQSAELA------DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHET 3896
Query: 943 RAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQ 1002
+ L + ++ L E + T +++ Q+++ KA +E DI E
Sbjct: 3897 AEPISDFLSVTEKKLANS----EPVGTQT---AKIQQQIIRH--KALEE--DI--ENHAT 3943
Query: 1003 GLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSE 1062
+ +AV K+ + L A +L KID + R+ + C R+ L+ Q
Sbjct: 3944 DVHQAV-KIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCC----RKAALLDQA--- 3995
Query: 1063 KIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST 1122
+ R+F D+ +E L V D + V +K+ + D
Sbjct: 3996 --LSNARLFGEDE------------VEVLNWLAEVEDKLSS------VFVKDFKQ--DVL 4033
Query: 1123 YRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVT 1182
+R+ + ++ +R I + LK GE +
Sbjct: 4034 HRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQ---------------- 4077
Query: 1183 KRGETLSWLKSRLKVLTEVSSEN-EAQKQGDELA-KLSSSFKALVTLLSEVEKMLSNFGD 1240
E L +K+R +T SS+ +Q +LA K S+++ L L EVE+ L+ G
Sbjct: 4078 ---EKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGG 4134
Query: 1241 CVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQ 1300
E + + KEV E +LDT N E + LL +
Sbjct: 4135 QSPTGEQIPQFQQRQKELKKEVMEH-RLVLDTVN--EVSRALL----------------E 4175
Query: 1301 QQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVV 1360
+A++G L +E+ + + T+ ++ I +++ +++E + +
Sbjct: 4176 LVPWRAREGLDKLVSDANEQYKLVSDTIG-------QRVDEIDAAIQRSQQYEQAADAEL 4228
Query: 1361 RYLFQTGSSHERFLSFSSL----ESLSSELEQTKEFSKRTESIAVQAENLVKEASEI--P 1414
++ +T + ++ + + +++L+ K FS + L SEI
Sbjct: 4229 AWVAET---KRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGT 4285
Query: 1415 LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEK 1474
G + K +LQ++ +S+ +Q + + E +E + + F +E LS WI E
Sbjct: 4286 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRA 4345
Query: 1475 ELNALETSSSAMDM------QISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESAR 1528
+ L + + + ++ Q++ +I E + + ++ + + + +
Sbjct: 4346 LIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEK 4405
Query: 1529 IKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKI 1588
+ + EE+R+ A L+ + +Q +F + + + +++ +L +P I
Sbjct: 4406 YQKAENMYAQIKEEVRQRALALDEAV-SQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 4464
Query: 1589 CSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQ------ 1642
+ + + + ++ LE L + A +++ R + A ++
Sbjct: 4465 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4524
Query: 1643 ----YEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEA---KASSPEMDISAD 1695
+EDI RA+ER+ ++L ++ ++++ LT ++ + SP +D S
Sbjct: 4525 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4584
Query: 1696 RVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755
+ +VE + ++ E + L L + + ++ +++++ W +
Sbjct: 4585 KQQVEAA----ETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWEN 4640
Query: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKD 1815
L + +R+ L+ + Q+ + L + W+ + +L T + L KD
Sbjct: 4641 LNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVG-----TDLNTVKD 4695
Query: 1816 HAAEVESKKGELQSLQGHLAKLGSLGRA--------EDLHLLQGKAEDCFQLFEEASQVV 1867
E++ K E+ Q + KL G D +++ + L+E + +
Sbjct: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKI 4755
Query: 1868 ERRQL----ALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDL------- 1916
RQ AL L +F + L L + ++A ++ + +IE +L
Sbjct: 4756 AHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPIS-GDPKVIEVELAKHHVLK 4814
Query: 1917 NDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTK 1976
ND L + +E+ + + +L + G R A C E L T+
Sbjct: 4815 NDVLAHQATVETVNKAGNELLESSA-----GDDASSLRSRLEAMNQCWE----SVLQKTE 4865
Query: 1977 QSEADALAVLKKA--FQDQKEELLKSIEDIEERTDKER----LKEPTRQALQQRLRVFNQ 2030
+ E + L++A F + E+ L + +E + + L E R+ L + +++Q
Sbjct: 4866 EREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQ 4925
Query: 2031 LEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCG 2090
L+ + ++ L K + +++ D + ++ + LE W + E + +
Sbjct: 4926 LKAKEETYNQLLD--KGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEE 4983
Query: 2091 LIDLMREYQNLK-------SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMN 2143
++L E+QN + + L AS + T+ Q +H+ N++N
Sbjct: 4984 ALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQ------IEEHKVFANEVN 5037
Query: 2144 YKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEK-------LEENM 2196
+ + G L +K D L+K + S +W V ++ L++
Sbjct: 5038 AHRDQIIELDQTGNQLKFLSQK---QDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDAR 5094
Query: 2197 DRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAE-ELLKEFESEVKNKA 2255
R + W ++ ++ E ++ + ISN + ++ + KEF+ + K
Sbjct: 5095 KRAKQFHEAWKKLIDWLEDAESHLDSEL-----EISNDPDKIKLQLSKHKEFQKTLGGKQ 5149
Query: 2256 LRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQ 2315
+ LKE T E L ++ K + + + L++ S Q
Sbjct: 5150 PVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQ 5209
Query: 2316 VEKFINDITTWFTKVEESLMNCAQ-NETCEALKKVKDIQKELQSQQSNISSTQENLNSLC 2374
+ + W KVE L + + + + D K Q + + T + L
Sbjct: 5210 FMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVL---- 5265
Query: 2375 RKYHSAELESLGRAMTGLIK--------KHEAVSQLCSKTQASLQESLEKH--FSESMQE 2424
K EL R T +K + + V +L Q+ L+++L++ F +++
Sbjct: 5266 -KRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHM 5324
Query: 2425 FQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHL 2484
EW A+ + D++ L++ + + + V + + +++ G+ + A
Sbjct: 5325 LLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVC 5384
Query: 2485 SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEER 2544
+++I+ IT F+ L + +Q L+ SEL + + +L WI E
Sbjct: 5385 HPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETT 5444
Query: 2545 FNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQ 2586
+ Q+I K + + + F+ E+ + +D++++
Sbjct: 5445 LIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTK 5486
Score = 116 bits (291), Expect = 9e-25
Identities = 355/2008 (17%), Positives = 756/2008 (37%), Gaps = 273/2008 (13%)
Query: 488 QLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLA--ESKLKSWIIKYGRRESVEQ 545
Q + ER EL L ++E K + L+ A E++ W++ E + Q
Sbjct: 3648 QCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT-EVEIINQ 3706
Query: 546 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLS 605
L ++ F + + ++ Q + + +++ G + + + M E A+W L+
Sbjct: 3707 QLADFKMFQKEQ--VDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLN 3764
Query: 606 VEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFF---------RN 656
+V + L+E + + ++ + + L +WL D E+++ + ++ +
Sbjct: 3765 KKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKL 3824
Query: 657 LPHWIQQHTAMNDA----GNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVK-QYAQAD 711
L + A D G + ++ + + QL L RW EL + + Q +
Sbjct: 3825 LQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLE 3884
Query: 712 EMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDL------EDIEQRVPV 765
++ + K++ + +S F + KKL+ V K+ Q + EDIE
Sbjct: 3885 DILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATD 3944
Query: 766 MDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKE--CYSPLLYESQQLLIP 823
+ KI + L SP E+G + + L+ + +++++ C L + Q L
Sbjct: 3945 VHQAVKIGQSLSSLT---SPAEQGV-LSEKIDSLQARYSEIQDRCCRKAALLD--QALSN 3998
Query: 824 LEELEKQMTSFYDSLGKINE-IITVLEREAQSSALFKQKHQELLACQE---NCKKTLTLI 879
+ + L ++ + + +V ++ + L +Q H + LA E N KK +
Sbjct: 3999 ARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQ-HADHLALNEEIVNRKKNVDQA 4057
Query: 880 EKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKF 939
K Q++ K T VL +Q ++ I + + + + +E +L KF
Sbjct: 4058 IKNGQALLKQTTGEEVLL------IQEKLDGIKTRYADITVTSSKALRTLEQARQLATKF 4111
Query: 940 EESRAELEKVLRIAQEGLEEKGDPE-------ELLRRHTEFFSQLDQR--VLNAFLKACD 990
+ + EL LR +E L G + +R E ++ + VL+ +
Sbjct: 4112 QSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSR 4171
Query: 991 ELTDILPEQEQQGLQEAVRKLHKQWK---------------DLQGEAPYHLL---HLKID 1032
L +++P + ++GL + V ++Q+K +Q Y L
Sbjct: 4172 ALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV 4231
Query: 1033 VEKNRFLASVEECRTELDRET-KLMPQEGSEKIIKEHRVFFSDKGPHH-----LC-EKRL 1085
E R L ++ R E D+ T +L Q+ I H+ + H C E++
Sbjct: 4232 AETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQK 4291
Query: 1086 QLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST-YRKLMEDPDKWKDYTSRFSEFS 1144
+++E L + E + ++S Y +L + + E S
Sbjct: 4292 TVLQEKTESL--------------IQQYEAISLLNSERYARLERAQVLVNQFWETYEELS 4337
Query: 1145 SWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSE 1204
WI + + AID H ++++ EE+R + E+++ K + L ++
Sbjct: 4338 PWIEETRALIAQLPSPAID---HEQLRQQQEEMR----QLRESIAEHKPHIDKLLKI--- 4387
Query: 1205 NEAQKQGDELAKLSSSFKALVT-LLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQ 1263
G +L +L+ +V + E M + + V+ + + +L+E +S S ++
Sbjct: 4388 ------GPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRAL---ALDEAVSQSTQIT 4438
Query: 1264 EQAEKI---LDT-ENL---FEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDR 1316
E +KI L+T ENL L+ K + + + ++ + Q L R
Sbjct: 4439 EFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRR 4498
Query: 1317 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
G E + + + L ++E Q++ Q+ WE + E E+F +
Sbjct: 4499 GEELIGRSQGADKDLA-AKEIQDKLDQMVFF-WEDIKARAEEREIKFLDVLELAEKF--W 4554
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKK 1436
+ +L + ++ T++ ES + + +++QQ ++ E +K+
Sbjct: 4555 YDMAALLTTIKDTQDIVHDLESPGI-----------------DPSIIKQQVEAA-ETIKE 4596
Query: 1437 LEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVT 1496
D L E+++ + ++ G++ + TEK + +++ ++A + K
Sbjct: 4597 ETDGLHEELEFIRIL-------GADL-IFACGETEKPEVRKSIDEMNNAWENLNKTWKER 4648
Query: 1497 IQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILG 1556
++++E + + V ++ Q+ ++ KL + G +L T+
Sbjct: 4649 LEKLEDAMQAAVQYQDTLQAMFDWLDN-----TVIKLCTMPPVGTDLN--------TVKD 4695
Query: 1557 HLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI 1616
L++ ++F+ + + Q + + + + +K + T+
Sbjct: 4696 QLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETD---------------------- 4733
Query: 1617 TAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLT 1676
RD + L+ +E++ + RQ LE L + + L ++
Sbjct: 4734 ------------RDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4781
Query: 1677 WLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASK 1736
WL E + + IS D +E EL L+N+V++ + + + L ++
Sbjct: 4782 WLTHTEELLDA-QRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAG 4840
Query: 1737 DDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQ 1796
DD ++ LE +++ W + Q +R LQS + + Q F + F + + S+L
Sbjct: 4841 DDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLS 4900
Query: 1797 TTSEISIMDHQVA--LTRHKDHAAEVESKKGELQSL--QGHLAKL-----GSLGRAEDL- 1846
+ + L H + +++++K+ L +G L L GS + E
Sbjct: 4901 ASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSV 4960
Query: 1847 -------HLLQGKAEDCFQLFEEASQVVERRQLALSH------LAEFLQSHAS-----LS 1888
H++ K E+ EEA + Q +L LAE + AS L+
Sbjct: 4961 ALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN 5020
Query: 1889 GILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGS 1948
+L Q+ + N +N + +IE D Q L+ + D +L K + + S
Sbjct: 5021 TVLSQIEEHKVFANEVNAHRDQIIELD-----QTGNQLKFLSQKQDVVLIK-NLLVSVQS 5074
Query: 1949 SEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERT 2008
++ R+ +ER ++L D K F + ++L+ +ED E
Sbjct: 5075 RWEKVVQRS--------IERGRSL--------DDARKRAKQFHEAWKKLIDWLEDAESHL 5118
Query: 2009 DKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVA--FAPEVDRE 2066
D E ++ +L + + L + + + +K + + ++D
Sbjct: 5119 DSELEISNDPDKIKLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF 5178
Query: 2067 INRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQE 2126
+ + WD E Q + + ++ + A+ L + +
Sbjct: 5179 LGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDL 5238
Query: 2127 DLKW-AFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKW 2185
DL H+ + ++ + + G+ L+ + D + VK ++ +W
Sbjct: 5239 DLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR----DDTTWVKGQLQELSTRW 5294
Query: 2186 LDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNC---------VPQMAENISNL-D 2235
V + RL +L + T + W + +P E + +L D
Sbjct: 5295 DTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLID 5354
Query: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2295
H + ++E +V N A+ + E+ V +T + I A + L A
Sbjct: 5355 THKEFMKKVEEKRVDV-NSAVAMGEVILAVCHPDCITTIKHW---ITIIRARFEEVLTWA 5410
Query: 2296 KEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKE 2355
K+ + + L + A + +E+ + W E +L+ Q + + +VK + E
Sbjct: 5411 KQHQQRLETALSELVANAELLEELL----AWIQWAETTLIQRDQEPIPQNIDRVKALIAE 5466
Query: 2356 LQSQQSNISSTQENLNSLCRKYHSAELE 2383
Q+ ++ Q +++ + + Y +E
Sbjct: 5467 HQTFMEEMTRKQPDVDRVTKTYKRKNIE 5494
Score = 75.9 bits (185), Expect = 2e-12
Identities = 188/1023 (18%), Positives = 399/1023 (39%), Gaps = 175/1023 (17%)
Query: 7728 MESKVSQNGDILIE-EMIEKLKKDY-----QEEIAIAQENKIQLQQMGERLAKASHESKA 7781
+E +++ D+L + +++E+ KD QE + Q Q Q++ +L KA E A
Sbjct: 1830 LELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKAL-EKDA 1888
Query: 7782 SEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQ--QLDKNMSSLRTWLAHIESELAK 7839
++ L V+D W L L ++++T V Q QL+ + LR W+ + L
Sbjct: 1889 KNLQKSLSSVSDTWNSRL-LHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNS 1947
Query: 7840 P-----IVYDSCNS-----EEIQRKLNEQQ--------ELQRDIEKHSTGVASVLNLCEV 7881
I DS N E++++ + E++ ++Q I +H+ ++ N +
Sbjct: 1948 KGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQML 2007
Query: 7882 -LLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLK-IEETWRLWQKFLDDYSR 7939
LL++ D ++Q +D ++ M E +K +++ + L+D
Sbjct: 2008 RLLNELQRSFQDI----LEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLC- 2062
Query: 7940 FEDWLKSSERTAAFPSSSGVIYTVA--KEELKKFEAFQRQVHECLTQLELINKQYRRLAR 7997
W+ +ER A ++ ++ + Q + T + K
Sbjct: 2063 --SWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFME 2120
Query: 7998 ENRTDSA----CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR------- 8046
EN+T + +L++ +H+ ++++ LQ+ + L+ + + ET +
Sbjct: 2121 ENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKEL 2180
Query: 8047 -------DSILVWLTEMDLQ----LTNIEHFSECD------------------------V 8071
D++L W+T + LTN+ + +
Sbjct: 2181 AENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKL 2240
Query: 8072 QAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKS----EPLDAAIIEEELDELRRYCQE 8127
+ + +KA QE+ + +++ P + +++++L EL+
Sbjct: 2241 DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYST 2300
Query: 8128 VFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLS 8187
+ E K++ L D+ E E W +RS L + +
Sbjct: 2301 SLAQSEAELKQV--QTLQDELQKFLQDHKEFES--------WLERSEKELENMHKGGSSP 2350
Query: 8188 LSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYL 8247
+L L+ + S + S H DL R + ++ D ++ +
Sbjct: 2351 ETLPSLLKRQGSFSEDVIS---------HKGDL---------RFVTISGQKVLDMENSFK 2392
Query: 8248 RGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI 8307
G + P L ++ +K+ + ++AL S+ +LG L+ Q Q +N
Sbjct: 2393 EG----------KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNS 2442
Query: 8308 IRSKTPTGPELDTSYKGYMKLLGECSSS--------IDSVKRLEHKLKEEE--------- 8350
S + + + KLL + +S + + K+L+ +L E +
Sbjct: 2443 ADSLQAWMQACEANVE---KLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKV 2499
Query: 8351 -------ESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNS 8403
E P + H ET T ++ ++ L + +++ + + Q L S
Sbjct: 2500 ARDIMEIEGEPAPDHRHVQET-TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2558
Query: 8404 IWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQ 8463
+ +G+ E+ LE Q LS+ + I+ + +L++ + +K+ + + F +
Sbjct: 2559 LLQSIGEVEQNLEGKQVSSLSSGV--IQEALATNMKLKQDIARQKSSLEATREMVTRFME 2616
Query: 8464 -ADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENID 8522
ADS + LQ +L++++ R++++C +E L+ L Q + F +S L +EN
Sbjct: 2617 TADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMEN-- 2674
Query: 8523 RRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLE 8582
K+ ++ + D +I +Q+ ++ E+ + Q + +L+ + +L D +
Sbjct: 2675 --KSRMLASGNQPDQDITH-FFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQ 2731
Query: 8583 AKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL------DTSGSV 8636
+++V L+ E+ + +KE EK D SS Q+ L + +T GS+
Sbjct: 2732 HQDRV----QNLRKDFTELQKTVKEREK--DASSCQEQLDEFRKLVRTFQKWLKETEGSI 2785
Query: 8637 SPT 8639
PT
Sbjct: 2786 PPT 2788
Score = 49.7 bits (117), Expect = 1e-04
Identities = 113/608 (18%), Positives = 233/608 (38%), Gaps = 90/608 (14%)
Query: 303 DEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ---MVESNLQDKYQSFK 359
+E L F NS+Q F W+ E+ L A ++ + + + + K
Sbjct: 4982 EEALNLATEFQNSLQEFIN-----------WLTLAEQSLNIASPPSLILNTVLSQIEEHK 5030
Query: 360 HFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALV---------KQSWDRVTSRLFDWHIQL 410
F + R QI L Q ++ LS Q +V + W++V R + L
Sbjct: 5031 VFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSL 5090
Query: 411 D------KSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD 464
D K + WL AE L E+ + ++ I+ +L +HK+ +
Sbjct: 5091 DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDK----IKLQLSKHKEFQKTLG 5146
Query: 465 AHKRAFHEIYRT-RSVNGIPVPPDQ-------LEDMAERFHFVSSTS--------ELHLM 508
+ + RT R++ + P+ L ++ +++ V S E L
Sbjct: 5147 GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLF 5206
Query: 509 KMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQ 568
+F++ L+ L E +L +G + V L+ + F K + T Q
Sbjct: 5207 SGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVF---QKELGKRTGTVQ 5263
Query: 569 ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNT 628
+LK++ + + S ++ V + E + +W + S +S LE+ + + + +T
Sbjct: 5264 VLKRSGRELI--ENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDT 5321
Query: 629 VASLQAWLEDAEKML-------NQSE------NAKKDFFRNLPHWIQQHTAMNDA---GN 672
V L WL +AE+ L + +E + K+F + + ++ +N A G
Sbjct: 5322 VHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVE---EKRVDVNSAVAMGE 5378
Query: 673 FLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQ-----ADEMDRMKKEYTDCVVTL 727
++ C +K + ++ R+ E+ KQ+ Q E+ + + + +
Sbjct: 5379 VILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWI 5438
Query: 728 SAFATEAHKKLSEPLEVSFMNVKLLIQD----LEDIEQRVPVMDAQYKIITK----TAHL 779
T ++ EP+ + VK LI + +E++ ++ P +D K + H
Sbjct: 5439 QWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNIEPTHA 5498
Query: 780 ITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLYES----QQLLIPLEELEKQMTSFY 835
E + G++ + + + E +P + + QQ+ + E ++++
Sbjct: 5499 PFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDAL 5558
Query: 836 DSLGKINE 843
D L ++ E
Sbjct: 5559 DRLEELKE 5566
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 310 bits (793), Expect = 5e-83
Identities = 628/3223 (19%), Positives = 1229/3223 (38%), Gaps = 528/3223 (16%)
Query: 21 LQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQG 80
++DE+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 1 MEDEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKG 59
Query: 81 RRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYF 140
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++
Sbjct: 60 ST--RVHALNNVNKALRVLQNNN-------VDLVNIGSTDIVDGNHKLTLGLIWNIILHW 110
Query: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 200
Q++ + N+ + Q N++K LL WV+ +
Sbjct: 111 QVKNVMKNI-----------------------------MAGLQQTNSEKILLSWVRQSTR 141
Query: 201 KQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGI 259
+ V +F SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI
Sbjct: 142 NYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGI 201
Query: 260 PRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF 319
+LLDPEDVD PD+KSI+ Y+ + P S + ++ E+LP P
Sbjct: 202 EKLLDPEDVDTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT------ 253
Query: 320 KREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPL 379
+E+ + +Q L + S+ + +++S+ + + Y
Sbjct: 254 -KEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQ 312
Query: 380 HRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQ 439
H +A +S+ S L + + LD+ A L + +WL AE L+ + +
Sbjct: 313 HL-------EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI- 360
Query: 440 QVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFH 497
++ + H+ + + AH+ I + ++ + + D+ ++ E+ +
Sbjct: 361 ---SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMN 417
Query: 498 FVSSTSE-LHLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ES 542
++S E L + ME +R+L L + K L W+ K R E
Sbjct: 418 LLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLED 477
Query: 543 VEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQ 600
+++ +Q + E+ EQ +V L + ++ G A E +K + + +
Sbjct: 478 LKRQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---R 531
Query: 601 WRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHW 660
W N+ +L++++ W R AWL + E +N+
Sbjct: 532 WANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI-------------- 577
Query: 661 IQQHTAMNDAGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDR 715
HT N ++ + ++ + DL KQ + L ++L +K + + +
Sbjct: 578 ---HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEA 634
Query: 716 MKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITK 775
+ C L + LE S + + + + VM+ + T+
Sbjct: 635 WLDNFARC-----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683
Query: 776 TAHLITKES-----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEK 829
L+ P + K S+++++L + E +S + L P + +
Sbjct: 684 EQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFR 743
Query: 830 QMTSFYDSLGKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKK 874
+ +F D K+N I + + + AL +Q E + A ++ +
Sbjct: 744 KEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803
Query: 875 TLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSR 934
+ + S+ + +N++ ++Q + Q+ + + T +++ +
Sbjct: 804 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 863
Query: 935 LMK----KFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLK 987
+ K + + ++E+ L+I L+EKG L F+ ++V + A K
Sbjct: 864 ICKDEVNRLSGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREK 922
Query: 988 ACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECR 1046
+ D LP Q A+R W Q E + L + D E +E+
Sbjct: 923 ELQTIFDTLPPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRL 971
Query: 1047 TELDR-ETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTP 1105
EL ++ L Q+ + S K P + K EE+
Sbjct: 972 GELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI-------------- 1017
Query: 1106 GTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTA 1165
K+L + + +KL E +K + + W++ + LK E
Sbjct: 1018 ---EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPAL 1070
Query: 1166 NHGEV-KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKAL 1224
E+ K+ +++ R V+ + ++ L + E + + + + + ++L + K L
Sbjct: 1071 GDSEILKKQLKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKEL 1126
Query: 1225 VTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF-------- 1276
T + + + KE +K LE+ +S K++ E E + E +
Sbjct: 1127 NTQWDHMCQQV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYK 1180
Query: 1277 ----------EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLES 1326
E ++ QQK ++ V IAQA P E L+K
Sbjct: 1181 TPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELE 1233
Query: 1327 TLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSEL 1386
TL T +W N + + L + + LS+ LE + L
Sbjct: 1234 TL---------------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWL 1274
Query: 1387 EQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIK 1446
+ + K TE+I AE E SE+ +N L + ++ Q++ L TL +
Sbjct: 1275 NEVEFKLKTTENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGV 1327
Query: 1447 TMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSS 1506
E++ + + F S + L ++K L S+ + + I+ ++ I+ +L++
Sbjct: 1328 MDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA 1387
Query: 1507 IVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKF 1564
+ + +A Q E+ +I++ LT EE+++H Q E +L + QK
Sbjct: 1388 YIADKVDAAQMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1442
Query: 1565 EENLR---KIQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQ 1607
+++ ++ Q + FE +L +K+ A ET V QE ++L +
Sbjct: 1443 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1502
Query: 1608 ALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLL 1661
+L + S + + R++V N + AL+ Y ++ + ER+ LE L
Sbjct: 1503 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1562
Query: 1662 AHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYS 1721
+++ KE++ WL + + + + ++ E+ +A Q E+ Q
Sbjct: 1563 KLSRKMRKEMNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1621
Query: 1722 KLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELL 1781
+ ++ E+L +V K + +++ L L+ W + + +N L + FD+ +
Sbjct: 1622 SITEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNV 1680
Query: 1782 LSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG 1841
+ WI + L + + + L R K AE+ + ++ S + A
Sbjct: 1681 DHITKWIIQADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA------ 1731
Query: 1842 RAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGIL 1891
+L+ + + C +L E + R A+SH L E Q ++ + +L
Sbjct: 1732 -----NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLL 1786
Query: 1892 RQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQ 1951
L E +N E D KD+N+ N ++ D + +I +
Sbjct: 1787 EPLE--AEIQQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERK 1835
Query: 1952 RTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKE 2011
R + L + +++L ++ +A ++ ++ Q ++LLK ++DIE++
Sbjct: 1836 REEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--A 1893
Query: 2012 RLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDRE 2066
L EP + R +++ EL + EL ++ +A+ +++ A A E + +
Sbjct: 1894 SLPEPRDE------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKR 1947
Query: 2067 INRLEVTWDDTKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRT 2120
+E + +RL IH + + ++ D+ E + S + + S ++
Sbjct: 1948 WREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVE 2007
Query: 2121 TI--------KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSS 2169
+ KD EDL F + E+ KN + Q+ +D SK L +
Sbjct: 2008 QLLNAPDLCAKDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERV 2064
Query: 2170 DFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE 2229
+ ++ +W V++ ++ R S+ W W + +
Sbjct: 2065 KLQEALSQLDF---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRK 2121
Query: 2230 -NISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQ 2282
I H + + LKE + + + + L++ ++ + + E L
Sbjct: 2122 TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLN 2181
Query: 2283 FIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCA 2338
++ ++L K+ E K L +F ++ +N+ W + + L
Sbjct: 2182 LRWQEVCKQLSDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGK 2234
Query: 2339 QNETCEALKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGL 2392
+ + E L++VK + +EL +Q + E +++ +LE+ L +
Sbjct: 2235 EQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQW 2294
Query: 2393 IKKHEAVSQLCSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLE 2450
IK A+ + + +A +++ LEK + ++ L + + +
Sbjct: 2295 IKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---Q 2351
Query: 2451 AKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQC 2510
D+Q +V Q ++ + +GQ LY K ++ ++ + E++A + +
Sbjct: 2352 EGPFDVQETEIAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRL 2408
Query: 2511 LKDKQALQ-DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEM 2569
L++ +A Q D A L + T+ + Q + K+ + K+EM
Sbjct: 2409 LQELRAKQPDLAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEM 2453
Query: 2570 FLGELL----------AARESLDKLSQRGQLLSEEGHGAG-------------------- 2599
+L A E D LS Q++ + G
Sbjct: 2454 PSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE 2513
Query: 2600 QEGRLCSQLLTSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQS 2642
Q +L+T+ QNL T E++++ +QEH + L E L+
Sbjct: 2514 QRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKD 2573
Query: 2643 MWFWVKAIQDRLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKL 2688
W++A ++ AE LG + D ++K++++ + + + + +
Sbjct: 2574 STQWLEAKEE----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNV 2629
Query: 2689 NMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVER 2748
++A + LR + + R + E + W I ++ LE +
Sbjct: 2630 DVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2689
Query: 2749 KNQLEQWMESVD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHR 2799
+ W+ + + E L+ G+KE L+ Q + E E HT H
Sbjct: 2690 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHN 2746
Query: 2800 LIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL--------- 2850
L S+++ E Q L D M ++RK ++ HL
Sbjct: 2747 LDENSQKILRSLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKR 2801
Query: 2851 MYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGA 2901
++L ++ E WL +EL R + + GD A QK+ K KE + +
Sbjct: 2802 LHL-SLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLET 2860
Query: 2902 SRLSRVE--------------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDS 2943
R+ E L PE + QN T E ++TE + L W+
Sbjct: 2861 VRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRK 2920
Query: 2944 VFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2986
+ +T LE L QE +L+ L Q + +W
Sbjct: 2921 IDET---LERL--------QELQEATDELDLKLRQAEVIKGSW 2952
Score = 214 bits (544), Expect = 4e-54
Identities = 373/2038 (18%), Positives = 822/2038 (40%), Gaps = 211/2038 (10%)
Query: 6661 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6720
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 766 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 816
Query: 6721 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6777
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 817 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 868
Query: 6778 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6835
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 869 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 927
Query: 6836 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6892
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 928 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 984
Query: 6893 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 985 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1040
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1041 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1100
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1101 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1160
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1161 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1220
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7190
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1221 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1280
Query: 7191 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7250
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1281 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1330
Query: 7251 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1331 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1389
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7365
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1390 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1449
Query: 7366 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7425
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1450 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1495
Query: 7426 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7483
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1496 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1554
Query: 7484 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7541
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1555 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1612
Query: 7542 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7601
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1613 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1670
Query: 7602 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7652
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1671 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1725
Query: 7653 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7712
D L + + IS LN R + + H++ + I L E
Sbjct: 1726 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1776
Query: 7713 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7772
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1777 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1826
Query: 7773 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7831
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1827 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1886
Query: 7832 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7890
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1887 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1934
Query: 7891 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 7932
E IQ L +RWR I + RRL EET + +
Sbjct: 1935 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1989
Query: 7933 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 7986
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1990 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2045
Query: 7987 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2046 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2105
Query: 8047 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8105
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2106 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2164
Query: 8106 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8163
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2165 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2224
Query: 8164 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8220
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2225 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2283
Query: 8221 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIK 8274
L+ +SRALP +++G+ + G + E ++ E +
Sbjct: 2284 ENKLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLN 2330
Query: 8275 NTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKG 8324
+ S + +Q+ + + F +Q+TE +++K P E+ + +
Sbjct: 2331 HLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQP 2390
Query: 8325 YMKLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ L + SS +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK
Sbjct: 2391 VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2450
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQ 8441
L M +L +D N W L D L+Q+ + + + D++ I I K K
Sbjct: 2451 -LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATM 2509
Query: 8442 KAVDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----G 8495
+ ++ R+ + + + + ++E+R + DR+ ++ +WD V L+ R
Sbjct: 2510 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 2569
Query: 8496 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 8555
+L+D+ + E L ++ K +D+ +Q + Q+ +L
Sbjct: 2570 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLR 2623
Query: 8556 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8613
+ Q V D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2624 QWQTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2677
Score = 188 bits (477), Expect = 2e-46
Identities = 535/2989 (17%), Positives = 1112/2989 (37%), Gaps = 447/2989 (14%)
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 325 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 382
Query: 2576 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2633
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 383 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 438
Query: 2634 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2686
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 439 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 497
Query: 2687 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2746
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 498 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557
Query: 2747 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2803
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 558 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 615
Query: 2804 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2863
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 616 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 661
Query: 2864 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2923
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 662 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 721
Query: 2924 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2983
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 722 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 780
Query: 2984 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3043
+ EG N D + +E L S+ E C+ + +
Sbjct: 781 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 817
Query: 3044 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3103
+ +I YN L Q L+Q A + WL T P
Sbjct: 818 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 854
Query: 3104 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3160
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 855 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 909
Query: 3161 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3216
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 910 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 969
Query: 3217 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3271
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 970 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1024
Query: 3272 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3331
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 1025 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1084
Query: 3332 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3391
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 1085 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1144
Query: 3392 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3434
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 1145 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1203
Query: 3435 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3494
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 1204 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1253
Query: 3495 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3554
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 1254 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1313
Query: 3555 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKF 3614
+ + T D G+ E + ++ + + R E + V + +L+EQ
Sbjct: 1314 QIRILAQTLTD---GGVMD------ELINEELETFNSRWRELHEE---AVRRQKLLEQSI 1361
Query: 3615 QQVDEWLKTAEEKKWH----------EEVTAYRDEVEEVGARAQEI--LDESHVNSRMGC 3662
Q E EK H +++ AY + + QE + + +
Sbjct: 1362 QSAQE-----TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISL 1416
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
+ + ++ + +VL QI ++++Q + +++ + + +D+
Sbjct: 1417 EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF----EQRLQESKMILDE 1472
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGH--------SLLKSAREKGERAVKYLEEGEAERLRKE 3774
V + + K++E + + H S +KS E + + + + + KE
Sbjct: 1473 VKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1532
Query: 3775 IHDHMEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
+ + + LK EL + V + LEK L L+++ + LT+W+A L
Sbjct: 1533 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1592
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVTLKDKIDQLQSDY 3888
+ ++++ K+ Q+ + + +KS+ E GEAL ++ ++ ++DK+ L S++
Sbjct: 1593 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNW 1652
Query: 3889 QDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA 3948
+ S + + + ++ + Q DH+ + Q
Sbjct: 1653 IAVTSRAEEWLNLLLEYQKHMETFD--------QNVDHITKWIIQ--------------- 1689
Query: 3949 ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR---------- 3998
A + E E +K ++D L++ +A L+ ++P ++ + +
Sbjct: 1690 ----ADTLLD--ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1743
Query: 3999 --AEAIKQVKH-FRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQ 4055
I ++ H F A+ + +T + ++ DIQ+ + +E ++ Q
Sbjct: 1744 LVEPQISELNHRFAAISHRIKT------GKASIPLKELEQFNSDIQKLLEPLEAEIQQGV 1797
Query: 4056 NLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ 4115
NL + E+ +E D + ++ + +R L+ I + +++ KQ
Sbjct: 1798 NLKE--EDFNKDMNE------DNEGTVKELLQRGDNLQQRITDERKRE------EIKIKQ 1843
Query: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL--CLQR-EEDLQRTRDYH 4172
+ T K N L K S K+ ++ QW RQ+++L CL E+ L +
Sbjct: 1844 QLLQT---KHNAL-KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1899
Query: 4173 DCMNVVEVFLE-KFTTEWDNLARSDAESTAVH--LEALKKLALALQERKYAIEDLKDQKQ 4229
D + E+ E + E N R AE + A++ + L +R IE K
Sbjct: 1900 DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIE----SKF 1955
Query: 4230 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4289
LN V+E+T + LE I +T + ++ ++L+
Sbjct: 1956 AQFRRLNFAQIHTVREETMMVMTEDMPLE--ISYVPSTYLTEITHVSQALLEVEQLLNAP 2013
Query: 4290 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4349
+ + + KQ ++ L + +K+ + ++ A V ER
Sbjct: 2014 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKK---TAALQSATPV-------ER 2063
Query: 4350 QVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQF---LMAVFQATSQIQQHERKIM 4406
+Q+ALS ++ + R+ ++++ + +F + Q ++ +Q RK
Sbjct: 2064 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2123
Query: 4407 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQ 4466
E+ + +K K Q + Q V L A G E++++ ++ + S + KL
Sbjct: 2124 IPENW-----EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2178
Query: 4467 ELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE 4526
L + V ++ S R + LE+ F+ D ++ WL++AD + + + +
Sbjct: 2179 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQ 2237
Query: 4527 LHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS--LNEVDHSYLSEKLNALPRQFNVI 4584
L +L + + ++E+ P + +L L TG +L S ++ + L KL +Q N+
Sbjct: 2238 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL----KQTNL- 2292
Query: 4585 VALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDG 4644
++ KV A+ + E+EAQ
Sbjct: 2293 ------QWIKVSRAL-------------PEKQGEIEAQ---------------------- 2311
Query: 4645 CRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLED 4704
+ LG+ +L +E ++ HL+ ++ Q E ++
Sbjct: 2312 -------IKDLGQLEKKLEDLEE------------QLNHLLLWLSPIRNQLEIYNQPNQE 2352
Query: 4705 TTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE---TLPAEEKLKMYHSLAGSLQDSGIVL 4761
QE E Q + ++ + + + +E T P + KL+ L+ + +L
Sbjct: 2353 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE---DLSSEWKAVNRLL 2409
Query: 4762 KRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI----D 4817
+ + DLAP L + + Q ++T + E S ++ + D
Sbjct: 2410 QELRAKQPDLAPGLTTIGASPTQTVTLVTQ---PVVTKETAISKLEMPSSLMLEVPALAD 2466
Query: 4818 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQ-----IHQEEVQSSLRIMNA 4872
F + DWL + + + +L+DI E I K + + Q Q I A
Sbjct: 2467 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 2526
Query: 4873 LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQ 4932
+ K K +A+ +I+ +E + E +QE L+ R+ L E + +
Sbjct: 2527 QNLKNKTSNQEARTIITDRIERIQNQWDE----VQEHLQNRRQQLNE----------MLK 2572
Query: 4933 AANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 4992
+ WLE +E Q+ G A L+S E T D + E L L
Sbjct: 2573 DSTQWLEAKEEAEQVLG------QARAKLESWKEGPYTVDAIQKKITETKQLAKDLR--- 2623
Query: 4993 KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLL-QRCTAQWHDYQKAREEVIELMNDTEK 5051
+ D+ +A LR S D +V ++ + A W K E + +T +
Sbjct: 2624 QWQTNVDVANDLALKLLRD--YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 2681
Query: 5052 KLSEFSL------------------LKTSSSHE--------AEEKLSEHKALVSVVNSFH 5085
L +F L L+ ++ E +E + + + L + +
Sbjct: 2682 LLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 2741
Query: 5086 EKIVALEEKASQLEKTGNDASKAT-LSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTG 5144
+ L+E + ++ ++ + A L R + + +W+ LR + + LE + D+W
Sbjct: 2742 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 2801
Query: 5145 FNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQT 5204
+ +++ + D+L + + + H F EL+ ++ + M +T
Sbjct: 2802 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI-MSTLET 2860
Query: 5205 LSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
+ + E+P E + R L +E+ + +L++ K E V T+ +
Sbjct: 2861 VRIFLT-------EQPLEGLEKLYQEPRELPPEERAQNVTRLLR---KQAEEVNTEWEKL 2910
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE 5324
+ + +ID LE LQ L EAT+ + AE K + + +L
Sbjct: 2911 NLHSADWQR-------KIDETLERLQ-ELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS 2962
Query: 5325 LSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
L L +K+K + A +E + LA+ LTT+
Sbjct: 2963 LQDHL--------------EKVKALRGEIAPLKENVSHVNDLARQLTTL 2997
Score = 187 bits (474), Expect = 5e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 5859 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5917
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 409 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 468
Query: 5918 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 5975
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 469 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 524
Query: 5976 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6033
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 525 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 572
Query: 6034 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6090
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 573 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 632
Query: 6091 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6142
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 633 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 688
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6188
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 689 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 748
Query: 6189 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6232
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 749 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 808
Query: 6233 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6280
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 809 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 866
Query: 6281 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6314
+ L GL E + QS K + + H +Q D
Sbjct: 867 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 926
Query: 6315 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6360
+SA TW+ E +L + + E E L + L ++E
Sbjct: 927 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 986
Query: 6361 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6412
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 987 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1039
Query: 6413 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6471
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1040 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1099
Query: 6472 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6525
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1100 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1159
Query: 6526 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6581
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1160 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1218
Query: 6582 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6635
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1219 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1275
Query: 6636 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6691
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1276 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1325
Query: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1326 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1382
Query: 6752 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6800
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1383 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1442
Query: 6801 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6843
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1443 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1502
Query: 6844 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6885
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1503 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1562
Query: 6886 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6915
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1563 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1622
Query: 6916 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 6962
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1623 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1682
Query: 6963 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7015
+ W + L + + K Q ED++K + E V+
Sbjct: 1683 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1731
Query: 7016 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7073
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1732 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1791
Query: 7074 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7127
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1792 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1846
Query: 7128 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7187
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1847 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1888
Query: 7188 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7247
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1889 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1933
Query: 7248 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7287
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1993
Query: 7288 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7345
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1994 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053
Query: 7346 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7402
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113
Query: 7403 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7461
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2172
Query: 7462 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7521
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2173 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2227
Query: 7522 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7576
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2228 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2287
Query: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7633
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2288 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2347
Query: 7634 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7691
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2348 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2405
Query: 7692 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7713
L +L ++ + L E A+
Sbjct: 2406 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2465
Query: 7714 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7767
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2466 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2521
Query: 7768 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7816
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2522 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2581
Query: 7817 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7876
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2582 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2633
Query: 7877 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 7936
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2634 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2689
Query: 7937 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 7985
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2690 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2744
Query: 7986 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8044
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2745 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2804
Query: 8045 ARDSILVWLTEMDLQLT 8061
+ +LVWL D +L+
Sbjct: 2805 SLQELLVWLQLKDDELS 2821
Score = 186 bits (472), Expect = 9e-46
Identities = 413/2178 (18%), Positives = 857/2178 (39%), Gaps = 306/2178 (14%)
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6585
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 388 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 446
Query: 6586 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6644
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 447 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 506
Query: 6645 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6690
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 507 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 566
Query: 6691 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6750
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 567 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 623
Query: 6751 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6807
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 624 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 683
Query: 6808 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6864
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 684 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 739
Query: 6865 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6923
I G + +K + + K + ++S + Q V E +D A
Sbjct: 740 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797
Query: 6924 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 6975
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 798 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 847
Query: 6976 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7033
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 848 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 907
Query: 7034 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7093
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 965
Query: 7094 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7153
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 966 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1025
Query: 7154 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7213
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1026 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1081
Query: 7214 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7270
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1082 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1138
Query: 7271 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7330
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1139 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1197
Query: 7331 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7383
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257
Query: 7384 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7441
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1258 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1313
Query: 7442 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7501
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1314 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1371
Query: 7502 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7560
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1372 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1418
Query: 7561 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7617
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1419 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1469
Query: 7618 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7675
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1470 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1529
Query: 7676 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7735
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1530 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1589
Query: 7736 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7789
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1590 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1646
Query: 7790 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7849
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1647 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1695
Query: 7850 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7909
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1696 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1737
Query: 7910 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 7968
+ C +E ++ SE F + S I T A L
Sbjct: 1738 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1772
Query: 7969 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8023
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1773 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1828
Query: 8024 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8083
R+T + K +++K QQ
Sbjct: 1829 RITD--------------------------------------------ERKREEIKIKQQ 1844
Query: 8084 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8143
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1845 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1896
Query: 8144 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8203
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1897 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1952
Query: 8204 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 8263
L + + + + M+ +P E YL +S ++
Sbjct: 1953 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST---YLTEITHVSQALLE---- 2005
Query: 8264 AYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK 8323
V+ NA + D L Q L K + DS Q +II SK
Sbjct: 2006 --VEQLLNAPDLCAKDFEDLFKQEESL-KNIKDSLQQSSGRIDIIHSKK----------- 2051
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
++++ S +E +E S F +WE + +
Sbjct: 2052 ---------TAALQSATPVERVKLQEALSQLDF---------------QWEKVNKMYKDR 2087
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQK 8442
+ R ++++KW++F+ D+ WL + E+ L + Q E + K LKELQ
Sbjct: 2088 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQD 2142
Query: 8443 AVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL 8501
+ R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2143 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2202
Query: 8502 MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
F + +L LE D + +P++ + + L++ +Q+ + EL Q +
Sbjct: 2203 NILSEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGIL 2259
Query: 8562 ASLQDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL---- 8608
L + +LV+A E D LE K K + L E+ IK+L
Sbjct: 2260 KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE 2319
Query: 8609 EKLLDVSSSQQDLSSWSS 8626
+KL D+ L W S
Sbjct: 2320 KKLEDLEEQLNHLLLWLS 2337
Score = 179 bits (455), Expect = 8e-44
Identities = 534/2881 (18%), Positives = 1106/2881 (38%), Gaps = 406/2881 (14%)
Query: 5886 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 5942
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 325 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 384
Query: 5943 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6002
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 385 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 442
Query: 6003 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6060
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 443 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 490
Query: 6061 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6105
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 491 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 550
Query: 6106 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6165
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 551 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 597
Query: 6166 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6224
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 598 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 639
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6284
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 640 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 688
Query: 6285 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 689 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 737
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6391
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 738 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 797
Query: 6392 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6443
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 798 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 853
Query: 6444 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6499
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 854 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 913
Query: 6500 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6551
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 914 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 973
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6607
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 974 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1033
Query: 6608 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6667
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1034 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1089
Query: 6668 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6724
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1090 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1149
Query: 6725 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6783
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1150 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1207
Query: 6784 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6843
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1208 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1265
Query: 6844 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6903
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1266 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1314
Query: 6904 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 6963
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1315 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1374
Query: 6964 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7014
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1375 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1432
Query: 7015 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7071
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1433 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1471
Query: 7072 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1472 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1526
Query: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1527 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1583
Query: 7192 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7248
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1584 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1637
Query: 7249 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7304
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1638 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1694
Query: 7305 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7358
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1695 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1748
Query: 7359 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7417
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1749 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1806
Query: 7418 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7477
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1807 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1854
Query: 7478 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7537
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1855 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1903
Query: 7538 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7597
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1904 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1961
Query: 7598 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7647
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1962 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2021
Query: 7648 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7694
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2022 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2081
Query: 7695 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7749
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2082 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2138
Query: 7750 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7809
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2139 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2198
Query: 7810 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7869
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2199 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2256
Query: 7870 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7924
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2257 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2312
Query: 7925 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 7966
+ +L +K D + WL + F I AK+
Sbjct: 2313 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2372
Query: 7967 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8015
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2431
Query: 8016 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8064
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2432 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491
Query: 8065 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8123
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2492 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2551
Query: 8124 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8183
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2552 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2611
Query: 8184 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 8243
+ LA+ LR +W + D++ DL + R D D +
Sbjct: 2612 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLR-----DYSADDTR 2649
Query: 8244 DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF--- 8299
+ MI E+ A + K S +ALE R L + LD +F
Sbjct: 2650 KVH----------MITENINASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAW 2696
Query: 8300 --QIQQTENIIRSKTPTGPELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEE 8351
+ + T N+++ T L+ S K + L GE + D L+ ++
Sbjct: 2697 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2756
Query: 8352 SLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDT 8411
SL G + + + + +W L+ ++L+ ++ + +W++ + L + WL
Sbjct: 2757 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2816
Query: 8412 EEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--- 8468
++EL + + + D ++ Q + ++ + ++ +I+S F E
Sbjct: 2817 DDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE 2874
Query: 8469 ------------------SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEM 8510
+R L+ + ++N W+++ +W+ + + L + Q E
Sbjct: 2875 KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 2934
Query: 8511 SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 8570
+ L L L + K P+ +L + LQDH +++ ++ E+ + V+ + D++ Q
Sbjct: 2935 TDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQ 2993
Query: 8571 L 8571
L
Sbjct: 2994 L 2994
Score = 179 bits (453), Expect = 1e-43
Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)
Query: 5183 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5240
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 374 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 432
Query: 5241 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5299
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 433 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 485
Query: 5300 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5355
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 486 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 545
Query: 5356 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5415
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 546 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 604
Query: 5416 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5475
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 605 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 652
Query: 5476 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5535
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 653 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 690
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 691 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 745
Query: 5596 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5654
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 746 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 803
Query: 5655 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5708
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 804 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 863
Query: 5709 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 864 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 907
Query: 5769 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5821
+ V R L L P+ + + + S ++ TD +
Sbjct: 908 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 967
Query: 5822 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5879
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 968 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1027
Query: 5880 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 5936
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 1028 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1087
Query: 5937 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 5996
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 1088 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1143
Query: 5997 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6053
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 1144 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1203
Query: 6054 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6113
+L E V+A + V E L E + T + + L +L +L E+ H
Sbjct: 1204 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1261
Query: 6114 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6172
+ ++ + E + L T++ PG E E+ + L
Sbjct: 1262 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1300
Query: 6173 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6232
++L+R +I I A+T D G +++++EL + +W LH
Sbjct: 1301 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1347
Query: 6233 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6282
+E +QKLL+ ++ QE Q + ++ L+ K D Q+ + S
Sbjct: 1348 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1407
Query: 6283 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6334
L + EE+ + G + I + QK VS + E+RL +
Sbjct: 1408 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1467
Query: 6335 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6377
+L E ET QE+ L K + E+ E++ Q +
Sbjct: 1468 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1527
Query: 6378 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6437
+N +++ + L + L + V +R Q+++ L+ + ++ VL LA +
Sbjct: 1528 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1587
Query: 6438 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6497
++ A E + + + KE + + LK +V + L K + + +
Sbjct: 1588 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1642
Query: 6498 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6540
+ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 1643 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1702
Query: 6541 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6598
QK ++ K E+ + K + M RK++ + +EL +
Sbjct: 1703 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1755
Query: 6599 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6653
+A+ R K + L+ L++ ++ + LE +E+ I V L EE N+D
Sbjct: 1756 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1808
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6713
D + L + Q + + D+ KR I I L+++ N L + K
Sbjct: 1809 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1865
Query: 6714 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6768
+ H+ W +Y+ ++ DL+ L + +L + + + +EL+ ++ L
Sbjct: 1866 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1918
Query: 6769 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6815
NA ++ + + + + S Q RL T+R E + +
Sbjct: 1919 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1978
Query: 6816 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6872
+ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 1979 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2030
Query: 6873 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 6932
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++ W
Sbjct: 2031 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2077
Query: 6933 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 6990
+ + + ++ + +E W + +++ W E+ L+ Q + A + L
Sbjct: 2078 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2137
Query: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050
K +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 2138 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2194
Query: 7051 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7110
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L ++L
Sbjct: 2195 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2253
Query: 7111 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7164
++ L++ +L P + L N LK+ N++W L E+ E K
Sbjct: 2254 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2313
Query: 7165 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7216
L QL ++ +D +Q S ++ Q + N+ + D+ + E+A + D
Sbjct: 2314 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2372
Query: 7217 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7252
++L KG K+ L +L + K Q++ A AS Q
Sbjct: 2373 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2432
Query: 7253 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7310
+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 2433 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2491
Query: 7311 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7363
DL I E + + K M P L+ L L +++E + R++ +
Sbjct: 2492 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2550
Query: 7364 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7423
W + R +L L +LE E + L Q KL G Y Q+
Sbjct: 2551 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2610
Query: 7424 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7481
+ E Q RQ + + + +LL DD + ++ ++ W+ + +R
Sbjct: 2611 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2670
Query: 7482 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7540
+R ++ R Q++ EK WL E + + ++ R L D KE
Sbjct: 2671 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2726
Query: 7541 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7591
K + QG Y E +++L S + +A LQ L + KW +
Sbjct: 2727 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2786
Query: 7592 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7643
+ L W++ + + L L+ +LS+ P ++H R
Sbjct: 2787 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2846
Query: 7644 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7689
+ + V T + ++ L + L A +++ +L ++ E + +
Sbjct: 2847 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2906
Query: 7690 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7746
WE+L + +++I E L E EL L Q E GD+LI+ + +
Sbjct: 2907 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2966
Query: 7747 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7804
L+ K + EIA +EN + + +L + + L +N RW+ L +
Sbjct: 2967 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3025
Query: 7805 RVKKLKE 7811
RV++L E
Sbjct: 3026 RVRQLHE 3032
Score = 176 bits (446), Expect = 9e-43
Identities = 377/1990 (18%), Positives = 829/1990 (41%), Gaps = 261/1990 (13%)
Query: 6844 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6903
A+ EV+SW+ E+ +Q + I N + + + + ++G+ +D+ Q V ++
Sbjct: 339 ALEEVLSWLLSAEDTLQA-QGEISNDV--EVVKDQFHTHEGYMMDLTAHQGRVG----NI 391
Query: 6904 LQISSQDVESKR---SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
LQ+ S+ + + + ++T+ EQ+ +N W+ L+ EK L +L + +
Sbjct: 392 LQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK--L 449
Query: 6961 QCLKTWFETQEKRLK--QQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7017
+ L W E+R + ++ +G D ++ ++ + L++ ++ ++ V + + +
Sbjct: 450 KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV 509
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7077
++ + ++ + L+ LG WAN+ +LL+ +L +W +++L E
Sbjct: 510 DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSE 569
Query: 7078 ARYSLSRFRLLTGSLEAVQV--QVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC-HPPV 7134
++++ TG + ++ + L L+ DLEK+++S+ K S+ LL + V
Sbjct: 570 KEDAVNKIHT-TGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSV 628
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQL-QSSKALLQLWQRYKDYSKQCASTVQQQEDRTNE 7193
T+ L W+NL++++ + Q S+A+ + TV R
Sbjct: 629 TQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQI 686
Query: 7194 LLKAATNK----------------------DIADDEVATWIQDCNDLLKG---------- 7221
L+K A + D+ E+ +WI +L+
Sbjct: 687 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 746
Query: 7222 -LGTVKDSLFFLH-ELGEQLKQQVDAS-AASAIQSDQLSLSQHLCALEQA---------- 7268
+K+ + + E E+ ++ DAS +A A+ ++ + +++QA
Sbjct: 747 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIE 806
Query: 7269 LCKQQTSLQAGVLDYET----FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEE 7324
C Q S + L+Y+ F L+ LE AE L+ Q P+ S+ + I+ +++
Sbjct: 807 FC-QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ-PTTPSEPTAIKSQLKI 864
Query: 7325 LKGQMLKFSSMAPDLDRLN-------ELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERF 7377
K ++ + S + P ++RL E G D + N H+ + S R
Sbjct: 865 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN---HFKQVFSDVQARE 921
Query: 7378 SKLQSFL-----LQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL--FQ 7430
+LQ+ +++Q + TW++ Q+E KL++ + + +QR EL Q
Sbjct: 922 KELQTIFDTLPPMRYQETMSAIRTWVQ---QSETKLSIPQLSVTDYEIMEQRLGELQALQ 978
Query: 7431 AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQ 7490
+ + +Q L+ + + + ++ + ++ + + +W+ + + + ++ Q
Sbjct: 979 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1038
Query: 7491 IRQWQRYREMAEKLRKWLVEVSYL---PMSGLGSVPI---PLQQARTLFDEVQFKEKVFL 7544
+ + ++ + + L+KW+ EV LG I L+Q R L ++Q
Sbjct: 1039 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ------- 1091
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
Q S E G+++ A+ + L+ EL E+ +W ++ +K+ L L+
Sbjct: 1092 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1151
Query: 7605 EKCEKGIADSLEKLRT-----FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQ 7659
+K +++ E + ++ PD ++ E R KE + +
Sbjct: 1152 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEA------K 1205
Query: 7660 LSLLKDTLSAYIS-ADDIS--ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSE 7716
+ LL +++++ I+ A ++ L + +E L ++ LC +L+ + + + E W
Sbjct: 1206 VKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1265
Query: 7717 KNKELCEWLTQMESKVSQNGDILI-EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKA 7775
++ +WL ++E K+ +I E I ++ + + +++N Q++ + + L
Sbjct: 1266 YLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDG 1325
Query: 7776 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7835
+ I +L N RW+ L + R K L++++ + Q+ +K++ ++ L I+
Sbjct: 1326 GVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1383
Query: 7836 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAEC 7895
+LA I D ++ ++ + E Q++Q D+ H ++L E+ H+
Sbjct: 1384 QLAAYIA-DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK------- 1426
Query: 7896 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERT 7950
++ Q+ +D + + +SM+ +RL+QK + FE L+ S E
Sbjct: 1427 EAAQRVLSQIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVK 1474
Query: 7951 AAFPS--SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 8008
P+ + V V + +L + + E +++E++ K R++ ++ +T++ L
Sbjct: 1475 MHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELD 1534
Query: 8009 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS- 8067
+ V ++ L +VT ++L+ + + + + WL D++LT
Sbjct: 1535 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1594
Query: 8068 -ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD------------- 8110
++ +++ KA Q+EI ++ I GE L + K E L
Sbjct: 1595 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIA 1654
Query: 8111 -AAIIEEELDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----S 8161
+ EE L+ L Y + E F + V+ K +I+ DE + + + ED
Sbjct: 1655 VTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLK 1713
Query: 8162 AALSDLH-----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSI 8210
A L+D+ D++A+ + + + L +P SE + R S SI
Sbjct: 1714 AELNDIRPKVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 1770
Query: 8211 PLEWDHDYD-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVM 8257
PL+ ++ L LE+ + + + ++E+ D + G V L +
Sbjct: 1771 PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRI 1830
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------S 8310
E +K+ + ++ L SQ R+ + +Q + Q +++++
Sbjct: 1831 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1890
Query: 8311 KTPTGPEL--DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 8368
K + PE + K + L + +++V+R L E+ ++ + T+ Q +
Sbjct: 1891 KLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS- 1945
Query: 8369 VIDRWELLQAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR-- 8420
RW ++++ A + L Q + D+ +++ T E+ + +
Sbjct: 1946 --KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2003
Query: 8421 LELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR---------- 8470
LE+ + +L K ++L K + K I S+ S SK++
Sbjct: 2004 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2063
Query: 8471 -DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKN 8526
LQ+ LSQ++ +W++V + ++ +G ++ + + FH ++ + L E R+
Sbjct: 2064 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2123
Query: 8527 EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 8586
I N + + + K+L + + Q V +L +++ + TD +EK
Sbjct: 2124 ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 2176
Query: 8587 VHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRST 8644
+ + R + + K++S K LE+ ++ S Q+DL+ + +E D S+ G+
Sbjct: 2177 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 2236
Query: 8645 PNRQKTPRGK 8654
++K + K
Sbjct: 2237 QLKEKLEQVK 2246
Score = 174 bits (440), Expect = 5e-42
Identities = 447/2617 (17%), Positives = 1007/2617 (38%), Gaps = 386/2617 (14%)
Query: 1251 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1309
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 349 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 400
Query: 1310 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1362
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 401 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 459
Query: 1363 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1416
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 460 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 514
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 515 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 574
Query: 1477 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1534
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 575 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 626
Query: 1535 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 627 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 669
Query: 1594 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1653
+T +E++++ T R+ + +E Q K+R
Sbjct: 670 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 704
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1713
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 705 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 761
Query: 1714 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1768
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 762 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 819
Query: 1769 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1822
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 820 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 874
Query: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1881
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 875 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 932
Query: 1882 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1937
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 933 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 992
Query: 1938 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1997
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 993 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1052
Query: 1998 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2056
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1053 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1112
Query: 2057 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2116
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 1113 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1172
Query: 2117 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2175
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 1173 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1229
Query: 2176 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2235
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 1230 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1285
Query: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2295
N E + E ++N E+ +++ L + + +L E +
Sbjct: 1286 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1345
Query: 2296 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2354
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 1346 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1400
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 1401 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1457
Query: 2415 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 1458 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1515
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 1516 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1575
Query: 2535 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2576
W+ E+ +R E + G++ Q EK+ + +V L +L
Sbjct: 1576 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1635
Query: 2577 ARESL--DKLS------------------------------------------QRGQLLS 2592
+E+L DKLS Q LL
Sbjct: 1636 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1695
Query: 2593 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2646
E Q+ + L + N +R T+++ + +H + +E + +
Sbjct: 1696 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1755
Query: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2692
AI R+ ++++ K+ LE+ S IQ LL E E++ + +
Sbjct: 1756 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1813
Query: 2693 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2744
G ++ L+ + QR+ + ++ ++ + +A L S + QW
Sbjct: 1814 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1873
Query: 2745 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2798
Y + + L + ++ +++K+ +P+ K K + + L ++ +AE +
Sbjct: 1874 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1933
Query: 2799 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2858
+ + ++ + + + F I TV +E M + E + + Y+ + +
Sbjct: 1934 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 1992
Query: 2859 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2912
T+ H ++ E+L D+ + D K+ +K + DS + + R+ + S
Sbjct: 1993 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2052
Query: 2913 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2972
Q+ T + + L W++ V++M Q G+ +
Sbjct: 2053 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2094
Query: 2973 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3026
+ +F +K + Q LT E +I E W +E+ D + + + L
Sbjct: 2095 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2154
Query: 3027 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3081
+ E+ + S D S K+ L + +C Q S K + ++ IL + F++
Sbjct: 2155 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2213
Query: 3082 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3139
+F WL A + + P ++ L++++ + E Q L + G L+S
Sbjct: 2214 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2272
Query: 3140 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3192
++ E+ ++ K+ W L +K+ +E L+ +++D E +
Sbjct: 2273 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2332
Query: 3193 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3252
WLS + +Y+ P + +Q + +P + + K Q L++ +
Sbjct: 2333 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2386
Query: 3253 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3291
A++ + ++ LSS++ A++ L +E ++ L I A Q
Sbjct: 2387 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2446
Query: 3292 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3331
F+ EL DW++ ++ S D ++ +K +
Sbjct: 2447 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2506
Query: 3332 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3390
A + +++ Q++ ++T +++ TS + T I +++ +++ W + + Q
Sbjct: 2507 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2566
Query: 3391 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3433
L L ++W ++ Q G W +D+++ + E+++ +LR
Sbjct: 2567 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2626
Query: 3434 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3493
T + A L ++L S +T +V H +T +++ +R+I +R E
Sbjct: 2627 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2675
Query: 3494 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3530
E+ RL Q++ DL+ F WL + + E + Q+ L+G
Sbjct: 2676 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2735
Query: 3531 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3590
+ H +L E Q +L S+ + + V+ R L+++ W +
Sbjct: 2736 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2782
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3627
+ R+ ++ + + Q++ WL+ +++
Sbjct: 2783 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 2819
Score = 167 bits (423), Expect = 4e-40
Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)
Query: 4070 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4124
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 342 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 399
Query: 4125 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4178
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 400 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 459
Query: 4179 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4238
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 460 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 503
Query: 4239 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4298
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 504 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 544
Query: 4299 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
LL D L L +Q L + + + + + + + + LS
Sbjct: 545 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 591
Query: 4359 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4417
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 592 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 646
Query: 4418 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4477
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 647 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 697
Query: 4478 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4536
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 698 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 757
Query: 4537 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4591
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 758 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 817
Query: 4592 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4651
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 818 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 871
Query: 4652 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4706
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 872 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 931
Query: 4707 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4760
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 932 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 987
Query: 4761 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4820
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 988 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1047
Query: 4821 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4880
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 1048 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1107
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 1108 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1167
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 4997
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 1168 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1225
Query: 4998 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5057
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1280
Query: 5058 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5112
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 1281 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1334
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 1335 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1394
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
A++ ++ Q L +S L++ G+E Q + + D
Sbjct: 1395 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1438
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5284
+ V +L ++ E ++ K + E K +L P +E + +
Sbjct: 1439 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1492
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5344
QL L + + +E + + ++ T P EL ++ + L +++
Sbjct: 1493 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1549
Query: 5345 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5400
K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 1550 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1605
Query: 5401 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5450
K +E K + + G+ LGK KL+ L+ I +AE L+
Sbjct: 1606 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1665
Query: 5451 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5510
L + H+E +++ ++ I KWI +A L + Q +E + + L E +I
Sbjct: 1666 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1721
Query: 5511 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5567
++++ ++ L + +C + + Q++EL + IK ++ K++++F
Sbjct: 1722 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1779
Query: 5568 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5618
++++KL LE Q L + + ++ + LL ++L+ ++ + +
Sbjct: 1780 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1839
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5678
++ Q L+ + + L + +++A + H Q + + E+++
Sbjct: 1840 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1894
Query: 5679 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5731
L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++ +
Sbjct: 1895 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1953
Query: 5732 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5791
K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 1954 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2004
Query: 5792 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5851
E +++P C ++I S+ R+ IH +A+
Sbjct: 2005 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2055
Query: 5852 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5911
+ P L L WE + + ++Q ++E+ +++ ++ + +
Sbjct: 2056 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2115
Query: 5912 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 5965
E L ++ P + EH + LQD I + Q ++ EE++ +S + D
Sbjct: 2116 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2169
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ L L R + + S +++ LEE Q+ L ++ + +E
Sbjct: 2170 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2216
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 2217 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2275
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6143
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q +
Sbjct: 2276 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2334
Query: 6144 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6200
WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 2335 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2382
Query: 6201 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6260
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 2383 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2418
Query: 6261 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6320
L G+ G PTQ + VT + A ++ S S+ LE +
Sbjct: 2419 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2471
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
T L D L + + +Q ++ D+++++E + K K
Sbjct: 2472 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2511
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ QR Q++E + N +N TS + + II
Sbjct: 2512 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2542
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
++IE IQ D ++E LQ + + E+ K
Sbjct: 2543 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2572
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6558
Q L K + E+ L LE+ +E G + K+ E +QL
Sbjct: 2573 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2621
Query: 6559 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6618
+++ ++ L L R + +K + A ++ KR +R LE E
Sbjct: 2622 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2678
Query: 6619 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6669
T L + +L + L + + + ++++ ++RL+ + + +Q L+ +
Sbjct: 2679 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2738
Query: 6670 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6725
+ + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 2739 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2798
Query: 6726 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6785
W R +L+ WLQ D L + + + V+ + F +E+ + +
Sbjct: 2799 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2854
Query: 6786 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6824
S L T L + ++ T LR + ++++W L +
Sbjct: 2855 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2914
Query: 6825 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6884
Q K+ + +++L ++ + + L + + K + ++ ++L+K K
Sbjct: 2915 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2972
Query: 6885 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 6944
+ +I + V VN Q+++ ++ + + + +N W++LQ V ++++
Sbjct: 2973 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3028
Query: 6945 LL 6946
L
Sbjct: 3029 QL 3030
Score = 162 bits (409), Expect = 2e-38
Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)
Query: 607 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 659
E +S S L E N DRY + + +WL AE L N E K F + +
Sbjct: 318 EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 377
Query: 660 WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 708
+ GN L E ++++Q+ LLN RW R ME +
Sbjct: 378 MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 437
Query: 709 QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 761
MD ++ + L+ K EPL ++K +Q DLE +
Sbjct: 438 HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 497
Query: 762 RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 804
RV + ++ +++ + +E+ K + +A + + E +LT
Sbjct: 498 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 557
Query: 805 KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 863
+ + +S L E + + + K SL K+ + LE++ QS Q
Sbjct: 558 EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 617
Query: 864 ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 906
+LL+ +N T + +EK + + + VT + QT +
Sbjct: 618 DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 675
Query: 907 QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 958
+ + Q +VK + K+ + +S + K+ + EL + ++ L+
Sbjct: 676 TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 735
Query: 959 EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 1002
PE + R FS L ++V NA L+ L EQ
Sbjct: 736 S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 791
Query: 1003 GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1059
+++A +L+ +W + L E L + + L +E+ T + K+ P
Sbjct: 792 SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 851
Query: 1060 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1118
SE IK D+ RL ++ +L ++ G + L A
Sbjct: 852 PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 905
Query: 1119 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1165
+ ++++ D + Y S +W+ +ET+L + D
Sbjct: 906 FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 965
Query: 1166 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1225
+ ++ +++ + ++ L +L + +K +++ + ++K E ++ +K L
Sbjct: 966 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1025
Query: 1226 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1278
+ L E +E+ ++ + + +K + E+ ++E+ + D+E L +
Sbjct: 1026 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1082
Query: 1279 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1338
+LL+ Q + + Q+I + E R EL++L + D + + +
Sbjct: 1083 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1140
Query: 1339 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1398
+ ++ L K + + + ++ Q + E +L EL++ E KR +
Sbjct: 1141 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1197
Query: 1399 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1452
A Q E VK +E P ++ L+++ +++ + L L KT+E V
Sbjct: 1198 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257
Query: 1453 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1512
W S E + W+ E E +L E + +I + +E+ +
Sbjct: 1258 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1313
Query: 1513 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1570
+ + AQ +T G I +L EL E A + + + Q+ E++L
Sbjct: 1314 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1373
Query: 1571 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1613
IQ+S++ + +LA I KI S T + + +++H +A + +
Sbjct: 1374 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1433
Query: 1614 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1670
S I + V + Q+ A +Q+ ++ IL K ALE + ++ +
Sbjct: 1434 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1493
Query: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
L+ + + S EM I R Q++Q Q E +
Sbjct: 1494 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1534
Query: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1790
+ V +KLH +L + + Q + K + + + E E W+
Sbjct: 1535 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1581
Query: 1791 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
EL S + M + A ++ + E++ + HL + +G A L +
Sbjct: 1582 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1634
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1908
GK E L E+ ++ +A+ S E+L + Q V+ T + + +
Sbjct: 1635 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1691
Query: 1909 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1968
+ L E + Q L+ L+ I K + +Q + A C
Sbjct: 1692 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1741
Query: 1969 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2026
+ L+ + SE + A + + K + LK +E +D ++L EP +QQ +
Sbjct: 1742 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1798
Query: 2027 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2080
+ FN +D +E + L + + Q+ D E+ + L+ + K L
Sbjct: 1799 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1856
Query: 2081 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ + + + +Y+ + K L++ + + +D+ +K + + K
Sbjct: 1857 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1916
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2184
++N ++ + + G + E +I S +F+ + T E T+
Sbjct: 1917 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1974
Query: 2185 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2243
+ ++E + + + L+ V E+E N P + + ++ + EE
Sbjct: 1975 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2029
Query: 2244 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2303
LK + ++ + R++ +HSK K TP + ++ L Q +++ ++ K
Sbjct: 2030 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2085
Query: 2304 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2357
F + +F DI W T+ E+ L E E K +K++Q +
Sbjct: 2086 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2145
Query: 2358 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2415
+Q+ + + + ++ + L + L ++ E QL K + Q+++
Sbjct: 2146 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2205
Query: 2416 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2475
F + EF W A A + G + L+ KL ++ +++ + Q L + +
Sbjct: 2206 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2264
Query: 2476 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2533
G + A +S + ++ ++ + N Q +K +AL + E+ +
Sbjct: 2265 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2310
Query: 2534 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
++LG+ ++ + + + +++ + ++L + E ++ +Q G +
Sbjct: 2311 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2358
Query: 2594 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2649
E A Q + ++L+ Q+L + T+ R + E +A+ LQ + +A
Sbjct: 2359 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2414
Query: 2650 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2707
Q LA +T+G+ T + ++ + ++ K KL M ++ AL N+
Sbjct: 2415 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2472
Query: 2708 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2767
+ W ++ + +Q + + N+ + ++ Q +E
Sbjct: 2473 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2513
Query: 2768 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2827
Q +P L+E +L++ S E T R+ E ++ Q
Sbjct: 2514 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2552
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
++++ + + +++ E++KD +L+A E L A+ +L W + A QKK+
Sbjct: 2553 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2612
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2947
++ K+L + + LA ++ ++ +A +H + + A W+ V +
Sbjct: 2613 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2672
Query: 2948 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 3004
++ LE L+ Q L ++F +A L +A E + +L+ ++ LLE +E+++
Sbjct: 2673 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2728
Query: 3005 CWHKGQEILDA 3015
W Q ++A
Sbjct: 2729 QWQDLQGEIEA 2739
Score = 159 bits (402), Expect = 1e-37
Identities = 580/3108 (18%), Positives = 1159/3108 (37%), Gaps = 547/3108 (17%)
Query: 2753 EQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTE 2812
+Q S+ Q E P+P +F + Q+ D TR+ S+ L E E
Sbjct: 268 QQITVSLAQGYERTSSPKP----RFKSYAYTQAAYVTTSDPTRSPF----PSQHL-EAPE 318
Query: 2813 DESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2872
D+SF + E + + T +E + + L A E ++ + K++ H
Sbjct: 319 DKSFGSSLMES-EVNLDRYQTALEEVLSWLLSAEDT----LQAQGEISNDVEVVKDQFHT 373
Query: 2873 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQA 2932
D +A Q ++ I +L S+ IG +LS E + + N L+++ +
Sbjct: 374 HEGYMMDLTAHQGRVGNILQL-GSKLIGTGKLSEDEETEVQEQMN-------LLNSRWEC 425
Query: 2933 LRADWKQWEDSVFQTQSCLENLVSQ-------------MALSEQEFSGQVAQLEQALEQF 2979
LR + + ++ + L+N + + E+ + L++ ++Q
Sbjct: 426 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 485
Query: 2980 SALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRD 3039
L + Q+ + T +V G AL E + + L + +CR++ D
Sbjct: 486 KVLQEDLEQEQVRVNSL-THMVVVVDESSGDHATAAL---EEQLKVLGDRWANICRWTED 541
Query: 3040 ----LSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTA 3095
L K L +E CL S KE + + F+D
Sbjct: 542 RWVLLQDILLKWQRLTEE-QCLF---SAWLSEKEDAVNKIHTTGFKD------------- 584
Query: 3096 KCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLS-KGELLSTLLTKEKAKGIQAKV 3154
QN E+ +SLQK+ ++ E + + + S K +LLSTL K K + K
Sbjct: 585 ------QN--EMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL----KNKSVTQKT 632
Query: 3155 TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3214
A +++ NL QK LE Q+ + +P S T+ V E+ +
Sbjct: 633 EAWLDNFARCWDNLVQK---LEKSTAQISQAVTTTQP-----SLTQTTVMETVTTV---- 680
Query: 3215 AKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNL 3274
REQ ++ EE+ PQ R Q S +
Sbjct: 681 -TTREQILVKHAQEELPPPPPQKKR---------------------------QITVDSEI 712
Query: 3275 TKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDS--YCHPTSDKSVLDSRTLKLEA 3332
K RLD + I EL W+T + +L S + + + D + K+ A
Sbjct: 713 RK----RLD----------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE-KVNA 757
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGI--PTIQQQLQSVKDMWASLLSAGIRCKSQ 3390
+ K EK +++ +++++ EG+ +I+Q + + W Q
Sbjct: 758 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC--------Q 809
Query: 3391 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESER----QHAELRDKTTMLGKAKLLNEEV 3446
L W YQ+ + F + +E +E Q + T + + K+ +EV
Sbjct: 810 LLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEV 869
Query: 3447 LSYSSL---LETIEVKGAGMTEHYVTQLELQ--------DLQERYRAIQERAKEAVTKSE 3495
S L +E ++++ + E + L ++ + +Q R KE T +
Sbjct: 870 NRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD 929
Query: 3496 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA- 3554
L + YQ + A W+ Q + KL + D E L +LQ LQ E Q+
Sbjct: 930 TLPPMR--YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSG 987
Query: 3555 --LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3612
L++ + PS I + E + W+ +L E + +NKLR ++
Sbjct: 988 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1047
Query: 3613 KFQQVDEWLKTAE---EKKWH-------------------EEVTAYRDEVEEVGARAQEI 3650
Q + +W+ + +++W ++ + + V Q+I
Sbjct: 1048 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1107
Query: 3651 LDESHVN--SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3708
+E+ SR+ + +L +++ + QV + + L+ ++ + LS +W
Sbjct: 1108 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1167
Query: 3709 THKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA 3768
+ + + + KT + L K +E+ +K A+E+ ++ +E +
Sbjct: 1168 AEEEY------------LERDFEYKTPDELQKAVEE----MKRAKEEAQQ-----KEAKV 1206
Query: 3769 ERLRKEIHDHMEQLKELTS-TVRKEHMTLEKGLH-LAKEFSDKCKALTQWIAEYQEILHV 3826
+ L + ++ + Q + ++KE TL L + KCK L + A + E+L
Sbjct: 1207 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1266
Query: 3827 PEEPKMELYEKKAQLSKYK--------------SLQQTVLSHEPSVKSVREKGEALLEL- 3871
E+ L E + +L + SL+ + E + +R + L +
Sbjct: 1267 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1326
Query: 3872 VQDVTLKDKIDQLQSDYQDLCSIG----KAMMEEIAGFEDRLNNLQMKGDTLI------- 3920
V D + ++++ S +++L K + + I ++ +L + ++L
Sbjct: 1327 VMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA 1386
Query: 3921 GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAW 3980
AD + A +Q S+ SLE E++KH ++ Q+ +
Sbjct: 1387 AYIADKVDAAQMPQEAQKIQSDLTSHEI----------SLE-EMKKHNQGKEAAQRVLSQ 1435
Query: 3981 LSAVQPDLEPSP------QPPLSRAEAIKQVK--------HFRAL------QEQARTYLD 4020
+ Q L+ Q P + + +++ K H AL QE ++ L+
Sbjct: 1436 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1495
Query: 4021 LLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQD 4077
C S + VK+ + + +T + I QK Q +N + E + LK +EL + +
Sbjct: 1496 H-CVNLYKSLSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTE 1553
Query: 4078 ADQQLQNMKR--RHSELELNIAQNMV----------SQVKDFVKKLQSKQA--------- 4116
QQL+ + R E+N+ + S V+ L S+ A
Sbjct: 1554 RKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEI 1613
Query: 4117 --------SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDL 4165
S+ + E + + K+E+ +++ LN W+ + ++ NL L+ ++ +
Sbjct: 1614 EKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHM 1673
Query: 4166 QRTRDYHDCMNVVEVFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ D + K+ + D L S+ + + LK+L L + + ++
Sbjct: 1674 ETFDQNVD-------HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDST 1726
Query: 4225 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQ 4283
+DQ ++ + ++LV+ Q S L R+ + IK K + + LE+ N +
Sbjct: 1727 RDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLL 1786
Query: 4284 ELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4343
E +E +Q N+ E D +++ D+ EL + L+ I D
Sbjct: 1787 EPLEAEIQQGVNLKEE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE------ 1833
Query: 4344 LGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER 4403
+R+ I+ Q+ N L DL QRRK KAL Q+ QA ++ +
Sbjct: 1834 ---RKREEIKIKQQLLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD 1887
Query: 4404 KIMFREHICLLPDD-----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEK 4458
+ + LP+ + + + + + L + + GL G + E T+ +
Sbjct: 1888 ---IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 1944
Query: 4459 SEVLGKLQELQSVYDSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWL 4507
S+ +++ + + + H ++E LE + V + E + L
Sbjct: 1945 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2004
Query: 4508 KQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDH 4567
+ ++ P++ + +L Q +NI + + + + L S V+
Sbjct: 2005 EVEQLLNAPDL-CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2063
Query: 4568 SYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMS 4627
L E L+ L Q+ + + KD+ + ++ + + I++ Q L+E E QFLR +
Sbjct: 2064 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKT 2122
Query: 4628 KVPTDLAVEE----ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4683
++P + + LQDG V L +E+ Q+ T +K+
Sbjct: 2123 QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGS 2179
Query: 4684 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEK 4743
L + + +Q R LE+ + E ++ + L+ N ++P E
Sbjct: 2180 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP- 2232
Query: 4744 LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4803
G Q L++V + +E+L PL + Q+ G + + E
Sbjct: 2233 --------GKEQQLKEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPE 2278
Query: 4804 TVTECESRMVQSIDFQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE 4862
+ E+++ Q+ ++SR+L + ++A++ L+ L+D++E++ + +
Sbjct: 2279 EQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSP 2338
Query: 4863 VQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTE 4919
+++ L I N + E D+QE A++ +Q + E
Sbjct: 2339 IRNQLEIYNQPNQ-------------------------EGPFDVQETEIAVQAKQPDVEE 2373
Query: 4920 IYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNL 4978
I S+ Q Y+ + A + +K +E S+E + L
Sbjct: 2374 ILSKGQHLYKE------------------------KPATQPVKRKLEDLSSEWKAVNRLL 2409
Query: 4979 EELHSLVATLDPLIKPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5032
+EL + L P + G + Q V + E ++ S +++
Sbjct: 2410 QELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA---- 2465
Query: 5033 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALE 5092
D+ +A E+ + ++ ++ + ++ + E + + KA + + ++ L
Sbjct: 2466 -DFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2523
Query: 5093 EKASQLE-KTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKK 5151
A L+ KT N ++ ++ + + +W ++ Q++ + L + + + T + ++
Sbjct: 2524 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2583
Query: 5152 ATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDG 5211
A +++ Q + KL + + + +L Q Q+ + + L +L+D
Sbjct: 2584 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2643
Query: 5212 AAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQET 5271
+A ++ + IT E + + + + + + +RE ++ET
Sbjct: 2644 SA----DDTRKVHMIT----------ENINASWRSIHKRVSEREAA----------LEET 2679
Query: 5272 KEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5331
L + LE+ LTEA ++ +++ L E
Sbjct: 2680 HRLLQ----QFPLDLEKFLAWLTEAETTANVLQDATRKER-----------------LLE 2718
Query: 5332 VALDLK-IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
+ +K + Q QD E+E L QK+ + L + D
Sbjct: 2719 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDD 2763
Query: 5391 QKVLGEELDGCNSKLMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5447
+L LD N K EL ++ LE + K L + +L + Q +R
Sbjct: 2764 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSR 2822
Query: 5448 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKE 5507
+ + +++ N++ + ++ + + T+ + + L +E +E
Sbjct: 2823 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 2882
Query: 5508 IDSELEA--MTEKLQYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK-- 5561
+ E A +T L+ T EK++ A+ R+ +E + RLQ LQ+A
Sbjct: 2883 LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDEL 2938
Query: 5562 DMKKFEAELKK-------------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSE 5607
D+K +AE+ K LQ LE+ +A G ++ LKE +SH L +
Sbjct: 2939 DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQ 2993
Query: 5608 MESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5655
+ +L +QL L ED+ L A+ E+ R H A
Sbjct: 2994 LTTL-----GIQLSPYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3033
Score = 157 bits (397), Expect = 4e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 5449 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5506
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 324 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 379
Query: 5507 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5565
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 380 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 436
Query: 5566 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5624
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 437 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 491
Query: 5625 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5684
L ++ V L H + + E + A+ E+++K L
Sbjct: 492 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 533
Query: 5685 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5731
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 534 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 593
Query: 5732 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5785
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 594 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 645
Query: 5786 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5845
L E+S ++IS PS T + + + + Q + P
Sbjct: 646 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 699
Query: 5846 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5905
Q + + + +L SW T + + + ++ + D +
Sbjct: 700 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 752
Query: 5906 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 753 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 791
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 792 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 835
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 836 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 895
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6145
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 896 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 939
Query: 6146 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6193
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 940 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 999
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6224
+ + K +E+ +K S+ E+QM
Sbjct: 1000 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1059
Query: 6225 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6280
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1060 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1119
Query: 6281 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6335
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1120 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1179
Query: 6336 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1180 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1236
Query: 6392 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6435
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1237 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1296
Query: 6436 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6493
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1297 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1340
Query: 6494 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6553
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1341 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1396
Query: 6554 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6613
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1397 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1450
Query: 6614 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6673
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1451 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1509
Query: 6674 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6730
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1510 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1569
Query: 6731 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6786
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1570 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1621
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1622 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1681
Query: 6847 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6906
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1682 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1733
Query: 6907 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 6965
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1734 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1787
Query: 6966 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7016
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1788 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1847
Query: 7017 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7071
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1848 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1907
Query: 7072 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7126
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1908 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1962
Query: 7127 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7185
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1963 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2011
Query: 7186 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7245
A D A +D + L +KDSL + + + A
Sbjct: 2012 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2053
Query: 7246 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7298
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2054 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2113
Query: 7299 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7356
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2114 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2173
Query: 7357 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7412
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2174 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2230
Query: 7413 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7469
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2231 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2290
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7529
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2291 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2350
Query: 7530 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7589
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2351 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2408
Query: 7590 LEEQKKKLAFL--------------------------------------------LKDWE 7605
L+E + K L L D+
Sbjct: 2409 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2468
Query: 7606 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7662
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2469 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2528
Query: 7663 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7722
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2529 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2585
Query: 7723 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7778
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2586 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2645
Query: 7779 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7838
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2646 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2703
Query: 7839 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7891
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2762
Query: 7892 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 7951
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2763 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2820
Query: 7952 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 7992
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2821 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2880
Query: 7993 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2881 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2936
Query: 8052 WLTEMDLQLTNIE 8064
E+DL+L E
Sbjct: 2937 ---ELDLKLRQAE 2946
Score = 135 bits (341), Expect = 1e-30
Identities = 421/2275 (18%), Positives = 879/2275 (38%), Gaps = 333/2275 (14%)
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
Q L SR++ L + +E+ L + L+ + L +DW T + + + +
Sbjct: 415 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLG 472
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3782
D + ++++ +VL +D+E+ + S V ++E + + + ++ L
Sbjct: 473 PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM----VVVVDESSGDHATAALEEQLKVL 528
Query: 3783 KELTSTVRK----EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK 3838
+ + + + + L+ L + +++ + W++E ++ ++ K+ K
Sbjct: 529 GDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVN-----KIHTTGFK 583
Query: 3839 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV--TLKDKIDQLQSDYQDLCSIGK 3896
Q SLQ+ + K + G+ L L QD+ TLK+K +++
Sbjct: 584 DQNEMLSSLQKLAVLKADLEKKKQSMGK-LYSLKQDLLSTLKNKSVTQKTE--------- 633
Query: 3897 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
A ++ A D L K I Q Q L Q ++ + + + Q +
Sbjct: 634 AWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT------VMETVTTVTTREQIL 687
Query: 3957 YQSLEHELQK---HVSRQDTLQ------------QCQAWLSAVQPDLEPSPQPPLSRAE- 4000
+ + EL RQ T+ + +W++ + L+ SP+ + R E
Sbjct: 688 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ-SPEFAIFRKEG 746
Query: 4001 ----------AIKQVK--HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4048
AI++ K FR LQ+ +R+ L+ M + A I+Q + +
Sbjct: 747 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEG-----VNADSIKQASEQLN 801
Query: 4049 QKLVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMK-----RRHSELELNIAQNM 4100
+ ++ L W E ++ + LQ +Q + + + E ++
Sbjct: 802 SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQ 861
Query: 4101 VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI------NHLNDQWLDLCRQS 4154
+ KD V +L Q + + + L +K + P + NH + D+ Q+
Sbjct: 862 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDV--QA 919
Query: 4155 NNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWD--NLARSDAESTAVHLEALKKLAL 4212
LQ D Y + M+ + ++++ T+ L+ +D E L L+ L
Sbjct: 920 REKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 979
Query: 4213 ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNL 4272
+LQE++ + L ++M + + + + +E RW +L + Q +
Sbjct: 980 SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1039
Query: 4273 EELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
+L +Q+ Q L +W E + E ++ + L + S+++ Q L S
Sbjct: 1040 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1099
Query: 4333 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4392
+ + ++ + ++ L + + + + V R++ L L + +
Sbjct: 1100 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1159
Query: 4393 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA-------QASLKTYQNEVTGLWAQ 4445
+ + Q E + + R+ PD++ K V+ K A +A +K V + AQ
Sbjct: 1160 EMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQ 1219
Query: 4446 GRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACH 4505
+ +E ++E L+ L + Y + + + + + LE+ +KA
Sbjct: 1220 APPVAQEALKKE-------LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANK 1272
Query: 4506 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEV 4565
WL + + N+ + E+ L +N++ S + N + L +T
Sbjct: 1273 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT---------LT 1323
Query: 4566 DHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLR 4625
D + E +N FN ++ ++ E + R++ L+E + QS E E
Sbjct: 1324 DGGVMDELINEELETFN-------SRWRELHEEAVRRQK---LLEQSIQSAQETEKSL-- 1371
Query: 4626 MSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLV 4685
++E+L+ D A A + + VD +E Q Q D H +
Sbjct: 1372 -------HLIQESLTFIDKQLA-----AYIADKVDAAQMPQE-----AQKIQSDLTSHEI 1414
Query: 4686 TLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK 4745
+L ++H + + +R L + Q K+ + ++ K +
Sbjct: 1415 SL-------------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM----KFR 1451
Query: 4746 MYHSLAG---SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4802
++ A LQ+S ++L V +HL P L+ + E + +QS L ++
Sbjct: 1452 LFQKPANFEQRLQESKMILDEVKMHL----PALETKSVE--QEVVQSQLNHCVNLYKSLS 1505
Query: 4803 ETVTECE------SRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKI 4856
E +E E ++VQ QTE + LD RV A L L+ ++ K+
Sbjct: 1506 EVKSEVEMVIKTGRQIVQK--KQTENPKELD--ERVTA-------LKLHYNELG---AKV 1551
Query: 4857 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDG---DIQEALRTR 4913
+++++ L++ + KE + L + D+E L + S ++G ++ +
Sbjct: 1552 TERKQQLEKCLKLSRKM---RKEMNVLTEWLAATDME--LTKRSAVEGMPSNLDSEVAWG 1606
Query: 4914 QATLTEIYSQ---CQRYYQVFQAANDWLEDAQELLQ-----LAGNGLDVES-AEENLKSH 4964
+AT EI Q + +V +A L + L++ L N + V S AEE L
Sbjct: 1607 KATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1666
Query: 4965 MEFFSTEDQFHSNLEELHSLVATLDPLI------KPTGKEDLEQKVASLELRSQRMSRDS 5018
+E+ + F N++ + + D L+ KP KED+ +++ + EL R DS
Sbjct: 1667 LEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKA-ELNDIRPKVDS 1725
Query: 5019 GAQVDLLQRCTAQWHDY-QKAREEVIELMNDTEKKLSEFSLLKTSSS----HEAEEKLSE 5073
D A D+ +K E I +N +S +KT + E E+ S+
Sbjct: 1726 TR--DQAANLMANRGDHCRKLVEPQISELNHRFAAISH--RIKTGKASIPLKELEQFNSD 1781
Query: 5074 HKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSM---TTVWQRWT--RLRAVA 5128
+ L+ + + ++ V L+E+ K N+ ++ T+ + + QR T R R
Sbjct: 1782 IQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1839
Query: 5129 QDQEKILE------------------DAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEK 5170
+ ++++L+ + +W + + + +D ++ KL S E
Sbjct: 1840 KIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL-ASLPEP 1898
Query: 5171 ASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAA----PTPGEEPPLMQEI 5226
+ ++ + EL++++ L +R+Q + +DGAA PT + +EI
Sbjct: 1899 RDERKIKEIDR-------ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI 1951
Query: 5227 TA--MQDRCLNMQE--KVKTNGKLVKQELKDREM------VETQINSVKCWVQETKEYLG 5276
+ Q R LN + V+ +V E E+ T+I V + E ++ L
Sbjct: 1952 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 2011
Query: 5277 NPTI---EIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE-LSLQLAEV 5332
P + + + ++ + L + +Q+ ++ +K L + P E + LQ A
Sbjct: 2012 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2071
Query: 5333 ALDL---KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT---DNVVQ 5386
LD K+ +D+ ++S + I K+ T + KT +N
Sbjct: 2072 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEH 2130
Query: 5387 AKTDQKVLGEELDGCNSK---LMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTIR 5442
AK + L E DG + + L+A ++ ++Q+ + L +K+G L Q+ +
Sbjct: 2131 AKY-KWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2189
Query: 5443 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5502
Q +R +L + + L E+ L + W+E+A +A + QL+E+ + L+
Sbjct: 2190 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2249
Query: 5503 EESKEIDSELEAMTEK-----LQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQ 5557
EE L+ + E + S +K+ ++ + + ++ + + + ++
Sbjct: 2250 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2309
Query: 5558 DAAKDMKKFEAELKKLQAALE-------------------------QAQATLTSPEVGRL 5592
KD+ + E +L+ L+ L Q T + + +
Sbjct: 2310 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2369
Query: 5593 SLKEQLSHRQHLLSE----------MESLKPKVQAVQLCQSALRIPE-DVVASLPLCHAA 5641
++E LS QHL E +E L + +AV LR + D+ L A+
Sbjct: 2370 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2429
Query: 5642 ----LRLQEEASRLQHTAIQQCNIMQAAVVQ---YEQYEQEMKHLQQLIEGAHREIEDKP 5694
+ L + + TAI + + + +++ + + L + + I+ +
Sbjct: 2430 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2489
Query: 5695 VATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749
V +++++ I + + Q ++ + Q+ L + + L K + +T+
Sbjct: 2490 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD 2544
Score = 129 bits (323), Expect = 2e-28
Identities = 269/1454 (18%), Positives = 572/1454 (39%), Gaps = 260/1454 (17%)
Query: 7259 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7318
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 311 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 367
Query: 7319 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7370
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 368 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 427
Query: 7371 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7428
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 428 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 487
Query: 7429 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7484
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 488 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 543
Query: 7485 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7544
++ + +WQR E WL E D V
Sbjct: 544 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 582
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 583 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 639
Query: 7605 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7664
+C + LEK ++ AV + LTQ +++
Sbjct: 640 ARCWDNLVQKLEK------------------------STAQISQAVTTTQPSLTQTTVM- 674
Query: 7665 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7724
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 675 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 719
Query: 7725 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQE--NKIQLQQMGERLAKAS 7776
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 720 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 779
Query: 7777 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKL--KETLVA----VQQLDKNMS 7824
E +E I+ ++N RW L++ R+ L + ++A +QQL++ +
Sbjct: 780 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 839
Query: 7825 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7884
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 840 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 890
Query: 7885 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 7944
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 891 EKGQGPMFLDADFV-AFTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 947
Query: 7945 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8004
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 948 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1007
Query: 8005 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNI 8063
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1008 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1067
Query: 8064 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8122
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1068 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1127
Query: 8123 ----RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSL 8177
CQ+V+ R E L ++ + L+ LS++H W ++ +
Sbjct: 1128 TQWDHMCQQVYARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEY 1172
Query: 8178 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
LE D +Y +L+ A+ +++E
Sbjct: 1173 ----------------------------------LERDFEYKTPDELQKAVEEMKRAKEE 1198
Query: 8238 EGQDDKDFYLRGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE--- 8284
Q + L ++ V+ P + EA K E N +G LE
Sbjct: 1199 AQQKEAKVKLL-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1257
Query: 8285 -------SQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8337
S + + K L++ F+++ TENI P G E E S +D
Sbjct: 1258 ACWHELLSYLEKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLD 1299
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKEL 8385
S LE+ ++ E++ P + + + GV+D RW L +A+ ++
Sbjct: 1300 S---LENLMRHSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQK 1355
Query: 8386 RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD 8445
++Q++Q Q +TE+ L +Q D Q K+ Q +
Sbjct: 1356 LLEQSIQSAQ--------------ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1401
Query: 8446 HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8505
+K + +L S E + + K+ +Q RV S ++ + LQD M+ +
Sbjct: 1402 AQK---IQSDLTSHEISLEEMKKH-------NQGKEAAQRVLSQIDVAQKKLQDVSMKFR 1451
Query: 8506 GFHEMSHGLLLMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRV 8561
F + ++ + E+ +D K + +++ +++ E++Q + + L E + V
Sbjct: 1452 LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV 1511
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD- 8620
+ Q++ + + E E+V + L +V+ ++LEK L +S +
Sbjct: 1512 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1571
Query: 8621 ---LSSWSSADELD 8631
L+ W +A +++
Sbjct: 1572 MNVLTEWLAATDME 1585
Score = 119 bits (298), Expect = 1e-25
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 528 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 578
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 941 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1000
Query: 579 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 638
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 1001 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1058
Query: 639 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 685
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 1059 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1118
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 741
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 1119 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1172
Query: 742 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 1173 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1225
Query: 797 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 856
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1278
Query: 857 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 915
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 1279 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1324
Query: 916 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 975
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 1325 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1379
Query: 976 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1031
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 1380 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1436
Query: 1032 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1437 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1487
Query: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1138
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1488 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1542
Query: 1139 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1195
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1543 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1599
Query: 1196 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1252
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1600 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1659
Query: 1253 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1299
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1660 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1719
Query: 1300 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1359
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1720 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1770
Query: 1360 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1418
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1771 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1825
Query: 1419 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1469
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1826 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1885
Query: 1470 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1521
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1886 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1943
Query: 1522 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1575
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1944 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2003
Query: 1576 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1628
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 2004 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2062
Query: 1629 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1688
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 2063 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2122
Query: 1689 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1748
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 2123 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2179
Query: 1749 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1808
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 2180 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2235
Query: 1809 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1859
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 2236 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2293
Query: 1860 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1917
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 2294 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2352
Query: 1918 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1974
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 2353 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2410
Query: 1975 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2031
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 2411 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2470
Query: 2032 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2091
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2471 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2519
Query: 2092 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2151
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2520 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2562
Query: 2152 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2211
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2563 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2603
Query: 2212 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2260
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2604 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2661
Query: 2261 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2317
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2662 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2714
Query: 2318 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2377
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2715 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2758
Query: 2378 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2429
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2759 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2818
Query: 2430 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2475
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2819 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2878
Query: 2476 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2879 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2938
Query: 2535 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2939 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 2996
Query: 2594 EG 2595
G
Sbjct: 2997 LG 2998
Score = 102 bits (255), Expect = 1e-20
Identities = 351/2051 (17%), Positives = 783/2051 (38%), Gaps = 301/2051 (14%)
Query: 3824 LHVPEEPKM--ELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKI 3881
L PE+ L E + L +Y++ + VLS + S + +A E+ DV +
Sbjct: 314 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSW---LLSAEDTLQAQGEISNDVEV---- 366
Query: 3882 DQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 3941
+D + M ++ + R+ N+ G LIG KL ++ +Q
Sbjct: 367 ------VKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQE 414
Query: 3942 TKDSYSA---ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR 3998
+ ++ A QS H + + Q L++ WL+ + + PL
Sbjct: 415 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK-LKELNDWLTKTEERTRKMEEEPLGP 473
Query: 3999 --AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQN 4056
+ +QV+ + LQE DL +++ + D + Q +
Sbjct: 474 DLEDLKRQVQQHKVLQE------DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 527
Query: 4057 LTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ- 4115
L W I + W+ LQD + Q + E + +S+ +D V K+ +
Sbjct: 528 LGDRWANICRWTEDRWVLLQDILLKWQRLTE-----EQCLFSAWLSEKEDAVNKIHTTGF 582
Query: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
N ++ + KL + E K +QS ++DL T
Sbjct: 583 KDQNEMLSSLQKLAVLKADLEKK-------------KQSMGKLYSLKQDLLSTLKNKSVT 629
Query: 4176 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKY--AIEDLKDQKQKMIE 4233
E +L+ F WDNL + +STA +A+ +L + + + ++Q +++
Sbjct: 630 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK 689
Query: 4234 HLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
H +EL ++R ++ I++++ V +T EL W
Sbjct: 690 HAQ---EELPPPPPQ--KKRQITVDSEIRKRLDVDIT-------------ELHSWITR-- 729
Query: 4294 PNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQ 4353
+EA+ QSP + + S+L+ K ++ + R + D + + +++
Sbjct: 730 ---SEAVLQSP-----EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVE 781
Query: 4354 KALSDAQSHVNCLSDLVGQRRKYLN-------KALSEKTQFLMA---VFQATSQIQQHER 4403
+ +++ + +D + Q + LN + LSE+ +L + +Q+QQ E+
Sbjct: 782 QMVNEGVN-----ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 836
Query: 4404 KIMFREHICLL-------PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-- 4454
E+ + P + Q+K CK L Q ++ L Q L ++
Sbjct: 837 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 896
Query: 4455 --------------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500
+Q S+V + +ELQ+++D++ ++E
Sbjct: 897 MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL----------------PPMRYQETM 940
Query: 4501 DKACHWLKQADI-VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTIL 4559
W++Q++ ++ P++++ + + +L + Q + E ++ L L T + +
Sbjct: 941 SAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 999
Query: 4560 PSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSE 4618
+E+ Y SE + ++ + + + K++E + ++ + I+ + ++E
Sbjct: 1000 KKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1058
Query: 4619 LEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQP-- 4675
++ FL+ + P L E L Q CR ++ ++ + +++ +N+ + ++ +P
Sbjct: 1059 VDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEF 1115
Query: 4676 ------------WQPDKMLHLVTLYHR---LKRQTEQRVSLLEDTTSAYQEHEKMCQQLE 4720
Q D M V Y R LK E+ VSL +D + + HE M Q E
Sbjct: 1116 ASRLETELKELNTQWDHMCQQV--YARKEALKGGLEKTVSLQKDLS---EMHEWMTQAEE 1170
Query: 4721 RQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAY 4780
L+ ++ + K +E A E++K A Q +K +T + + P+A
Sbjct: 1171 EYLE--RDFEYKTPDELQKAVEEMKRAKEEA---QQKEAKVKLLTESVNSVIAQAPPVAQ 1225
Query: 4781 EKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPV 4840
E + ++++ + L + + E + + + ++ WL V+ +L
Sbjct: 1226 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1285
Query: 4841 YLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLA 4897
+ ++I E + + H E+ + +RI L +L
Sbjct: 1286 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRI----------------------LAQTLT 1323
Query: 4898 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDV--E 4955
+ +D I E L T + E++ + R ++ + + ++ ++ L L L +
Sbjct: 1324 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1383
Query: 4956 SAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMS 5015
+ ++ + +L S +L+ + K ++ Q+V S +Q+
Sbjct: 1384 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1443
Query: 5016 RDSGAQVDLLQRCTAQWHDYQKAR---EEVIELMNDTEKKLSEFSLLKTSSSH--EAEEK 5070
+D + L Q+ Q+++ +EV + E K E ++++ +H +
Sbjct: 1444 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1503
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
LSE K+ V +V +IV ++ + E L +T + + L A +
Sbjct: 1504 LSEVKSEVEMVIKTGRQIVQKKQTENPKE----------LDERVTALKLHYNELGAKVTE 1553
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+++ LE + ++ TE + +L SA + + L + + + E+
Sbjct: 1554 RKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEI 1613
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE-ITAMQDRCLNMQEKVKTNGKLVKQ 5249
E+Q+ L ++++ + + G++ L+++ ++ + + + + + L+ +
Sbjct: 1614 EKQKVHL-----KSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLE 1668
Query: 5250 ELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEE-LQILLTEATNHRQNIEKMAE 5308
K E + ++ + W+ + L + Q E+ L+ L E + R ++ +
Sbjct: 1669 YQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD 1728
Query: 5309 EQKEKYLG-------LYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSR 5361
+ L SEL+ + A ++ +K + +KE+EQ +
Sbjct: 1729 QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT-GKASIPLKELEQFNS------- 1780
Query: 5362 QIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KVLGEELDGCNSKLMELDAAVQKFLEQN 5419
D+ +L L+A+ V K + K + E+ +G +L++ +Q+ +
Sbjct: 1781 -------DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1833
Query: 5420 GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHL-EEYNEMLELILKWIEKA-KV 5477
+ + K+ +L + ++ ++ K SH +Y + +LK ++ K
Sbjct: 1834 RKREEIKIKQ--QLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKK 1891
Query: 5478 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLT----------SVYC 5527
LA S + R++ + KEID EL+ E+L + +
Sbjct: 1892 LA-------SLPEPRDE--------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA 1936
Query: 5528 TEKMSQQVAELGRETEE---------LRQMIKIRLQNLQDAAKDM--------KKFEAEL 5570
E Q+++ RE E Q+ +R + + +DM + E+
Sbjct: 1937 VEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI 1996
Query: 5571 KKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKP---KVQAVQLCQSALRI 5627
+ AL + + L +P++ ++ + L + +SL+ ++ + ++A
Sbjct: 1997 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ 2056
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
V + L A +L + ++ + +V ++ ++ ++K Q + A
Sbjct: 2057 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2116
Query: 5688 REIEDKPVATS--------NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAK 5739
+ + + + ++ELQ I + + + + + E+I +SK ++ K
Sbjct: 2117 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 2176
Query: 5740 HATMLLTVTEV 5750
++ L EV
Sbjct: 2177 LGSLNLRWQEV 2187
Score = 49.3 bits (116), Expect = 2e-04
Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)
Query: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 200
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 2244 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2300
Query: 201 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 255
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 2301 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2360
Query: 256 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 306
E+ V +PD + I++ K P + + S++ + + +L
Sbjct: 2361 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2411
Query: 307 ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 328
PG + S Q ++ I K
Sbjct: 2412 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2471
Query: 329 -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 383
E+ W+ ++ + +++ +L+D + K E +R Q+E LI
Sbjct: 2472 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2531
Query: 384 KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 431
K S +A ++ WD V L + QL++ L WL E A
Sbjct: 2532 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2587
Query: 432 ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 488
R ++ + T + IQ+K+ + K L ++ R + + + + D
Sbjct: 2588 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2643
Query: 489 LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 540
D + H ++ S +H E LE +RLL L K +W+ +
Sbjct: 2644 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2703
Query: 541 ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 586
+V Q +E+SK E + Y L + ++ +++ ++
Sbjct: 2704 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2763
Query: 587 AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 646
A + + ++ +W L + ++RS LE W R ++ L WL+ + L++
Sbjct: 2764 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2823
Query: 647 ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 702
DF +Q+ ++ A ++T + ++ L+ + L + +L+
Sbjct: 2824 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2878
Query: 703 EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 755
E ++ +A + R+ ++ + V T L+ + + +K+ E LE +Q+
Sbjct: 2879 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2930
Query: 756 LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 815
L++ + + Q ++I K S Q G + ++ E++ ++ +PL
Sbjct: 2931 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2980
Query: 816 ESQQLLIPLEELEKQMTSFYDSLGKIN 842
++ + + +L +Q+T+ L N
Sbjct: 2981 --KENVSHVNDLARQLTTLGIQLSPYN 3005
Score = 35.4 bits (80), Expect = 2.5
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 5868 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5927
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2902 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2961
Query: 5928 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 5983
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2962 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3016
Query: 5984 STIRMKASGKRQLLEEKLND 6003
+++ + + L E D
Sbjct: 3017 KLLQVAVEDRVRQLHEAHRD 3036
>gi|33624861 spectrin repeat containing, nuclear envelope 2 isoform 2
[Homo sapiens]
Length = 429
Score = 309 bits (791), Expect = 9e-83
Identities = 187/457 (40%), Positives = 260/457 (56%), Gaps = 50/457 (10%)
Query: 8309 RSKTPTGPELDTSYK---GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQ 8365
R+ P P T YK G + L + + L ++E+ L G Q
Sbjct: 5 RNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITE------Q 58
Query: 8366 TAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELST 8425
+G DRWE++QAQ L +L++KQNLQ Q NSD+++I WL TE ELE L+ + +
Sbjct: 59 QSGAFDRWEMIQAQELHNKLKIKQNLQ---QLNSDISAITTWLKKTEAELEMLKMAKPPS 115
Query: 8426 DIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
DIQ IEL++K+L+E+ KA D KA+++S+N+ S EF Q +S ES +LQ RL Q++ W+
Sbjct: 116 DIQEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEA 175
Query: 8486 VCSLLEEWRGLLQDALMQCQG--------------FHEMSHGLLLMLENIDRRKNEIVPI 8531
++ WRG L+ +LMQCQG FH++S LLL L + R+ +
Sbjct: 176 AQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASAKNRRQKAHVT 235
Query: 8532 DSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIG 8591
D D L + ++LMQ++ EL+E Q +V LQ++S LL+ G DC+EA+EKVHVI
Sbjct: 236 DPKADPRALLECRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIE 295
Query: 8592 NRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTP 8651
+LK L ++VS+ + L+ +Q S S DE+D SG P +
Sbjct: 296 KKLKQLREQVSQDLMALQ------GTQNPASPLPSFDEVD-SGDQPPAT----------- 337
Query: 8652 RGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAALPLQLLLLLLI 8711
S P P R+T+G ++ PG R R FL RV+RAALPLQLLLLLL+
Sbjct: 338 ------SVPAPRAKFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQLLLLLLL 391
Query: 8712 GLACLVPMSEEDYSCALSNNFARSFHPMLRYTNGPPP 8748
LACL+P SEEDYSC +NNFARSF+PMLRYTNGPPP
Sbjct: 392 LLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPP 428
Score = 41.2 bits (95), Expect = 0.046
Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 28/340 (8%)
Query: 5838 TDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKY 5897
TD K P E G T + WE ++ +++ + + Q+
Sbjct: 31 TDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQ---AQELHNKLKIKQNLQQL 87
Query: 5898 QDSLQSISTKMEAIE-----LKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSS 5952
+ +I+T ++ E LK+++ P + E ++ Q ++ + + + S
Sbjct: 88 NSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEILKAFDTYKALVVSVNVS 147
Query: 5953 LAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQ 6012
E L +ES E+ + Q +L A + + G RQ L + + +
Sbjct: 148 SKEFLQTESPESTELQSRLRQLSLLWEAAQ-GAVDSWRGGLRQSLMQCQGSKTRPRSDVL 206
Query: 6013 ALQRYRCEADELDSWLLSTK-----ATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVV 6067
+ + + L WL S K A + + P+ ++ +LM + LVE + +V
Sbjct: 207 FFKDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQVD 266
Query: 6068 ALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQ--- 6124
L E+S +LL++G EAE+ K+ ++ L +L+ + + +QGT
Sbjct: 267 MLQEIS---NSLLIKGHGEDCIEAEE---KVHVIEKKLKQLREQVSQDLMALQGTQNPAS 320
Query: 6125 -----EKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSS 6159
++ +S AT P + RTT ++ S
Sbjct: 321 PLPSFDEVDSGDQPPATSVPAPRAKFRAVRTTEGEEETES 360
Score = 36.2 bits (82), Expect = 1.5
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 12/88 (13%)
Query: 7793 DRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESEL-----AKPIVYDSCN 7847
DRW+ + K+K+ L QQL+ ++S++ TWL E+EL AKP +
Sbjct: 64 DRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEAELEMLKMAKP----PSD 116
Query: 7848 SEEIQRKLNEQQELQRDIEKHSTGVASV 7875
+EI+ ++ QE+ + + + V SV
Sbjct: 117 IQEIELRVKRLQEILKAFDTYKALVVSV 144
>gi|5032287 dystrophin Dp427p1 isoform [Homo sapiens]
Length = 3681
Score = 308 bits (789), Expect = 2e-82
Identities = 628/3221 (19%), Positives = 1227/3221 (38%), Gaps = 528/3221 (16%)
Query: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
DE+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 7 DEREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST 65
Query: 83 MKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQI 142
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++Q+
Sbjct: 66 --RVHALNNVNKALRVLQNNN-------VDLVNIGSTDIVDGNHKLTLGLIWNIILHWQV 116
Query: 143 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 202
+ + N+ + Q N++K LL WV+ +
Sbjct: 117 KNVMKNI-----------------------------MAGLQQTNSEKILLSWVRQSTRNY 147
Query: 203 TGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPR 261
+ V +F SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI +
Sbjct: 148 PQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEK 207
Query: 262 LLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKR 321
LLDPEDVD PD+KSI+ Y+ + P S + ++ E+LP P +
Sbjct: 208 LLDPEDVDTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------K 258
Query: 322 EDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHR 381
E+ + +Q L + S+ + +++S+ + + Y H
Sbjct: 259 EEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL 318
Query: 382 DGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQV 441
+A +S+ S L + + LD+ A L + +WL AE L+ + +
Sbjct: 319 -------EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI--- 364
Query: 442 HEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFV 499
++ + H+ + + AH+ I + ++ + + D+ ++ E+ + +
Sbjct: 365 -SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLL 423
Query: 500 SSTSE-LHLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVE 544
+S E L + ME +R+L L + K L W+ K R E ++
Sbjct: 424 NSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLK 483
Query: 545 QLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWR 602
+ +Q + E+ EQ +V L + ++ G A E +K + + +W
Sbjct: 484 RQVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWA 537
Query: 603 NLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQ 662
N+ +L++++ W R AWL + E +N+
Sbjct: 538 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI---------------- 581
Query: 663 QHTAMNDAGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMK 717
HT N ++ + ++ + DL KQ + L ++L +K + + +
Sbjct: 582 -HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWL 640
Query: 718 KEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTA 777
+ C L + LE S + + + + VM+ + T+
Sbjct: 641 DNFARC-----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQ 689
Query: 778 HLITKES-----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQM 831
L+ P + K S+++++L + E +S + L P + ++
Sbjct: 690 ILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749
Query: 832 TSFYDSLGKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTL 876
+F D K+N I + + + AL +Q E + A ++ + +
Sbjct: 750 GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWI 809
Query: 877 TLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLM 936
+ S+ + +N++ ++Q + Q+ + + T +++ ++
Sbjct: 810 EFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKIC 869
Query: 937 K----KFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKAC 989
K + + ++E+ L+I L+EKG L F+ ++V + A K
Sbjct: 870 KDEVNRLSGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKEL 928
Query: 990 DELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTE 1048
+ D LP Q A+R W Q E + L + D E +E+ E
Sbjct: 929 QTIFDTLPPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGE 977
Query: 1049 LDR-ETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGT 1107
L ++ L Q+ + S K P + K EE+
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI---------------- 1021
Query: 1108 CHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANH 1167
K+L + + +KL E +K + + W++ + LK E
Sbjct: 1022 -EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGD 1076
Query: 1168 GEV-KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVT 1226
E+ K+ +++ R V+ + ++ L + E + + + + + ++L + K L T
Sbjct: 1077 SEILKKQLKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNT 1132
Query: 1227 LLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF---------- 1276
+ + + KE +K LE+ +S K++ E E + E +
Sbjct: 1133 QWDHMCQQV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP 1186
Query: 1277 --------EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTL 1328
E ++ QQK ++ V IAQA P E L+K TL
Sbjct: 1187 DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL 1239
Query: 1329 DGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQ 1388
T +W N + + L + + LS+ LE + L +
Sbjct: 1240 ---------------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNE 1280
Query: 1389 TKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTM 1448
+ K TE+I AE E SE+ +N L + ++ Q++ L TL +
Sbjct: 1281 VEFKLKTTENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMD 1333
Query: 1449 EMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIV 1508
E++ + + F S + L ++K L S+ + + I+ ++ I+ +L++ +
Sbjct: 1334 ELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI 1393
Query: 1509 GLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEE 1566
+ +A Q E+ +I++ LT EE+++H Q E +L + QK +
Sbjct: 1394 ADKVDAAQMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQ 1448
Query: 1567 NLR---KIQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQAL 1609
++ ++ Q + FE +L +K+ A ET V QE ++L ++L
Sbjct: 1449 DVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSL 1508
Query: 1610 ESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAH 1663
+ S + + R++V N + AL+ Y ++ + ER+ LE L
Sbjct: 1509 SEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKL 1568
Query: 1664 WQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKL 1723
+++ KE++ WL + + + + ++ E+ +A Q E+ Q +
Sbjct: 1569 SRKMRKEMNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSI 1627
Query: 1724 LQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLS 1783
++ E+L +V K + +++ L L+ W + + +N L + FD+ +
Sbjct: 1628 TEVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1686
Query: 1784 FSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRA 1843
+ WI + L + + + L R K AE+ + ++ S + A
Sbjct: 1687 ITKWIIQADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA-------- 1735
Query: 1844 EDLHLLQGKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQ 1893
+L+ + + C +L E + R A+SH L E Q ++ + +L
Sbjct: 1736 ---NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEP 1792
Query: 1894 LRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRT 1953
L E +N E D KD+N+ N ++ D + +I +R
Sbjct: 1793 LE--AEIQQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKRE 1841
Query: 1954 SCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERL 2013
+ L + +++L ++ +A ++ ++ Q ++LLK ++DIE++ L
Sbjct: 1842 EIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASL 1899
Query: 2014 KEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREIN 2068
EP + R +++ EL + EL ++ +A+ +++ A A E + +
Sbjct: 1900 PEPRDE------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWR 1953
Query: 2069 RLEVTWDDTKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI 2122
+E + +RL IH + + ++ D+ E + S + + S ++ +
Sbjct: 1954 EIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQL 2013
Query: 2123 --------KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDF 2171
KD EDL F + E+ KN + Q+ +D SK L +
Sbjct: 2014 LNAPDLCAKDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL 2070
Query: 2172 SLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-N 2230
+ ++ +W V++ ++ R S+ W W + +
Sbjct: 2071 QEALSQLDF---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2127
Query: 2231 ISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFI 2284
I H + + LKE + + + + L++ ++ + + E L
Sbjct: 2128 IPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLR 2187
Query: 2285 EADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQN 2340
++ ++L K+ E K L +F ++ +N+ W + + L +
Sbjct: 2188 WQEVCKQLSDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQ 2240
Query: 2341 ETCEALKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIK 2394
+ E L++VK + +EL +Q + E +++ +LE+ L + IK
Sbjct: 2241 QLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIK 2300
Query: 2395 KHEAVSQLCSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAK 2452
A+ + + +A +++ LEK + ++ L + + +
Sbjct: 2301 VSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEG 2357
Query: 2453 LHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLK 2512
D+Q +V Q ++ + +GQ LY K ++ ++ + E++A + + L+
Sbjct: 2358 PFDVQETEIAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQ 2414
Query: 2513 DKQALQ-DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFL 2571
+ +A Q D A L + T+ + Q + K+ + K+EM
Sbjct: 2415 ELRAKQPDLAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPS 2459
Query: 2572 GELL----------AARESLDKLSQRGQLLSEEGHGAG--------------------QE 2601
+L A E D LS Q++ + G Q
Sbjct: 2460 SLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQR 2519
Query: 2602 GRLCSQLLTSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMW 2644
+L+T+ QNL T E++++ +QEH + L E L+
Sbjct: 2520 RPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST 2579
Query: 2645 FWVKAIQDRLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNM 2690
W++A ++ AE LG + D ++K++++ + + + + +++
Sbjct: 2580 QWLEAKEE----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDV 2635
Query: 2691 AIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2750
A + LR + + R + E + W I ++ LE +
Sbjct: 2636 ANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLE 2695
Query: 2751 QLEQWMESVD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLI 2801
+ W+ + + E L+ G+KE L+ Q + E E HT H L
Sbjct: 2696 KFLAWLTEAETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLD 2752
Query: 2802 AKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MY 2852
S+++ E Q L D M ++RK ++ HL ++
Sbjct: 2753 ENSQKILRSLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLH 2807
Query: 2853 LDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASR 2903
L ++ E WL +EL R + + GD A QK+ K KE + + R
Sbjct: 2808 L-SLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVR 2866
Query: 2904 LSRVE--------------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVF 2945
+ E L PE + QN T E ++TE + L W+ +
Sbjct: 2867 IFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKID 2926
Query: 2946 QTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2986
+T LE L QE +L+ L Q + +W
Sbjct: 2927 ET---LERL--------QELQEATDELDLKLRQAEVIKGSW 2956
Score = 214 bits (544), Expect = 4e-54
Identities = 373/2038 (18%), Positives = 822/2038 (40%), Gaps = 211/2038 (10%)
Query: 6661 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6720
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 770 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 820
Query: 6721 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6777
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 821 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 872
Query: 6778 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6835
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 873 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 931
Query: 6836 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6892
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 932 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 988
Query: 6893 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 989 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1044
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1045 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1104
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1105 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1164
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1165 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1224
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7190
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1225 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1284
Query: 7191 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7250
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1285 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1334
Query: 7251 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1335 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1393
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7365
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1394 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1453
Query: 7366 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7425
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1454 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1499
Query: 7426 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7483
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1500 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1558
Query: 7484 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7541
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1559 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1616
Query: 7542 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7601
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1617 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1674
Query: 7602 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7652
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1675 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1729
Query: 7653 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7712
D L + + IS LN R + + H++ + I L E
Sbjct: 1730 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1780
Query: 7713 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7772
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1781 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1830
Query: 7773 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7831
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1831 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1890
Query: 7832 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7890
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1891 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1938
Query: 7891 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 7932
E IQ L +RWR I + RRL EET + +
Sbjct: 1939 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1993
Query: 7933 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 7986
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1994 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2049
Query: 7987 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2050 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2109
Query: 8047 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8105
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2110 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2168
Query: 8106 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8163
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2169 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2228
Query: 8164 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8220
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2229 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2287
Query: 8221 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIK 8274
L+ +SRALP +++G+ + G + E ++ E +
Sbjct: 2288 ENKLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLN 2334
Query: 8275 NTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKG 8324
+ S + +Q+ + + F +Q+TE +++K P E+ + +
Sbjct: 2335 HLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQP 2394
Query: 8325 YMKLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ L + SS +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK
Sbjct: 2395 VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2454
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQ 8441
L M +L +D N W L D L+Q+ + + + D++ I I K K
Sbjct: 2455 -LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATM 2513
Query: 8442 KAVDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----G 8495
+ ++ R+ + + + + ++E+R + DR+ ++ +WD V L+ R
Sbjct: 2514 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 2573
Query: 8496 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 8555
+L+D+ + E L ++ K +D+ +Q + Q+ +L
Sbjct: 2574 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLR 2627
Query: 8556 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8613
+ Q V D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2628 QWQTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2681
Score = 188 bits (477), Expect = 2e-46
Identities = 535/2989 (17%), Positives = 1112/2989 (37%), Gaps = 447/2989 (14%)
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 386
Query: 2576 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2633
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 387 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 442
Query: 2634 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2686
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 443 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 501
Query: 2687 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2746
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 502 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
Query: 2747 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2803
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 562 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 619
Query: 2804 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2863
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 620 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 665
Query: 2864 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2923
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 666 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 725
Query: 2924 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2983
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 726 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 784
Query: 2984 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3043
+ EG N D + +E L S+ E C+ + +
Sbjct: 785 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 821
Query: 3044 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3103
+ +I YN L Q L+Q A + WL T P
Sbjct: 822 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 858
Query: 3104 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3160
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 859 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 913
Query: 3161 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3216
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 914 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 973
Query: 3217 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3271
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 974 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1028
Query: 3272 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3331
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 1029 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1088
Query: 3332 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3391
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 1089 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1148
Query: 3392 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3434
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 1149 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1207
Query: 3435 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3494
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 1208 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1257
Query: 3495 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3554
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 1258 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1317
Query: 3555 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKF 3614
+ + T D G+ E + ++ + + R E + V + +L+EQ
Sbjct: 1318 QIRILAQTLTD---GGVMD------ELINEELETFNSRWRELHEE---AVRRQKLLEQSI 1365
Query: 3615 QQVDEWLKTAEEKKWH----------EEVTAYRDEVEEVGARAQEI--LDESHVNSRMGC 3662
Q E EK H +++ AY + + QE + + +
Sbjct: 1366 QSAQE-----TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISL 1420
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
+ + ++ + +VL QI ++++Q + +++ + + +D+
Sbjct: 1421 EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF----EQRLQESKMILDE 1476
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGH--------SLLKSAREKGERAVKYLEEGEAERLRKE 3774
V + + K++E + + H S +KS E + + + + + KE
Sbjct: 1477 VKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1536
Query: 3775 IHDHMEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
+ + + LK EL + V + LEK L L+++ + LT+W+A L
Sbjct: 1537 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1596
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVTLKDKIDQLQSDY 3888
+ ++++ K+ Q+ + + +KS+ E GEAL ++ ++ ++DK+ L S++
Sbjct: 1597 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNW 1656
Query: 3889 QDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA 3948
+ S + + + ++ + Q DH+ + Q
Sbjct: 1657 IAVTSRAEEWLNLLLEYQKHMETFD--------QNVDHITKWIIQ--------------- 1693
Query: 3949 ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR---------- 3998
A + E E +K ++D L++ +A L+ ++P ++ + +
Sbjct: 1694 ----ADTLLD--ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1747
Query: 3999 --AEAIKQVKH-FRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQ 4055
I ++ H F A+ + +T + ++ DIQ+ + +E ++ Q
Sbjct: 1748 LVEPQISELNHRFAAISHRIKT------GKASIPLKELEQFNSDIQKLLEPLEAEIQQGV 1801
Query: 4056 NLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ 4115
NL + E+ +E D + ++ + +R L+ I + +++ KQ
Sbjct: 1802 NLKE--EDFNKDMNE------DNEGTVKELLQRGDNLQQRITDERKRE------EIKIKQ 1847
Query: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL--CLQR-EEDLQRTRDYH 4172
+ T K N L K S K+ ++ QW RQ+++L CL E+ L +
Sbjct: 1848 QLLQT---KHNAL-KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1903
Query: 4173 DCMNVVEVFLE-KFTTEWDNLARSDAESTAVH--LEALKKLALALQERKYAIEDLKDQKQ 4229
D + E+ E + E N R AE + A++ + L +R IE K
Sbjct: 1904 DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIE----SKF 1959
Query: 4230 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4289
LN V+E+T + LE I +T + ++ ++L+
Sbjct: 1960 AQFRRLNFAQIHTVREETMMVMTEDMPLE--ISYVPSTYLTEITHVSQALLEVEQLLNAP 2017
Query: 4290 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4349
+ + + KQ ++ L + +K+ + ++ A V ER
Sbjct: 2018 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKK---TAALQSATPV-------ER 2067
Query: 4350 QVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQF---LMAVFQATSQIQQHERKIM 4406
+Q+ALS ++ + R+ ++++ + +F + Q ++ +Q RK
Sbjct: 2068 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2127
Query: 4407 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQ 4466
E+ + +K K Q + Q V L A G E++++ ++ + S + KL
Sbjct: 2128 IPENW-----EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2182
Query: 4467 ELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE 4526
L + V ++ S R + LE+ F+ D ++ WL++AD + + + +
Sbjct: 2183 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQ 2241
Query: 4527 LHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS--LNEVDHSYLSEKLNALPRQFNVI 4584
L +L + + ++E+ P + +L L TG +L S ++ + L KL +Q N+
Sbjct: 2242 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL----KQTNL- 2296
Query: 4585 VALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDG 4644
++ KV A+ + E+EAQ
Sbjct: 2297 ------QWIKVSRAL-------------PEKQGEIEAQ---------------------- 2315
Query: 4645 CRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLED 4704
+ LG+ +L +E ++ HL+ ++ Q E ++
Sbjct: 2316 -------IKDLGQLEKKLEDLEE------------QLNHLLLWLSPIRNQLEIYNQPNQE 2356
Query: 4705 TTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE---TLPAEEKLKMYHSLAGSLQDSGIVL 4761
QE E Q + ++ + + + +E T P + KL+ L+ + +L
Sbjct: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE---DLSSEWKAVNRLL 2413
Query: 4762 KRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI----D 4817
+ + DLAP L + + Q ++T + E S ++ + D
Sbjct: 2414 QELRAKQPDLAPGLTTIGASPTQTVTLVTQ---PVVTKETAISKLEMPSSLMLEVPALAD 2470
Query: 4818 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQ-----IHQEEVQSSLRIMNA 4872
F + DWL + + + +L+DI E I K + + Q Q I A
Sbjct: 2471 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 2530
Query: 4873 LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQ 4932
+ K K +A+ +I+ +E + E +QE L+ R+ L E + +
Sbjct: 2531 QNLKNKTSNQEARTIITDRIERIQNQWDE----VQEHLQNRRQQLNE----------MLK 2576
Query: 4933 AANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 4992
+ WLE +E Q+ G A L+S E T D + E L L
Sbjct: 2577 DSTQWLEAKEEAEQVLG------QARAKLESWKEGPYTVDAIQKKITETKQLAKDLR--- 2627
Query: 4993 KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLL-QRCTAQWHDYQKAREEVIELMNDTEK 5051
+ D+ +A LR S D +V ++ + A W K E + +T +
Sbjct: 2628 QWQTNVDVANDLALKLLRD--YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 2685
Query: 5052 KLSEFSL------------------LKTSSSHE--------AEEKLSEHKALVSVVNSFH 5085
L +F L L+ ++ E +E + + + L + +
Sbjct: 2686 LLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 2745
Query: 5086 EKIVALEEKASQLEKTGNDASKAT-LSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTG 5144
+ L+E + ++ ++ + A L R + + +W+ LR + + LE + D+W
Sbjct: 2746 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 2805
Query: 5145 FNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQT 5204
+ +++ + D+L + + + H F EL+ ++ + M +T
Sbjct: 2806 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI-MSTLET 2864
Query: 5205 LSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
+ + E+P E + R L +E+ + +L++ K E V T+ +
Sbjct: 2865 VRIFLT-------EQPLEGLEKLYQEPRELPPEERAQNVTRLLR---KQAEEVNTEWEKL 2914
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE 5324
+ + +ID LE LQ L EAT+ + AE K + + +L
Sbjct: 2915 NLHSADWQR-------KIDETLERLQ-ELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS 2966
Query: 5325 LSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
L L +K+K + A +E + LA+ LTT+
Sbjct: 2967 LQDHL--------------EKVKALRGEIAPLKENVSHVNDLARQLTTL 3001
Score = 187 bits (474), Expect = 5e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 5859 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5917
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 413 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 472
Query: 5918 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 5975
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 473 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 528
Query: 5976 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6033
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 529 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 576
Query: 6034 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6090
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 577 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 636
Query: 6091 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6142
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 637 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 692
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6188
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 693 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 752
Query: 6189 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6232
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 753 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 812
Query: 6233 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6280
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 813 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 870
Query: 6281 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6314
+ L GL E + QS K + + H +Q D
Sbjct: 871 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 930
Query: 6315 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6360
+SA TW+ E +L + + E E L + L ++E
Sbjct: 931 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 990
Query: 6361 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6412
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 991 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1043
Query: 6413 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6471
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103
Query: 6472 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6525
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163
Query: 6526 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6581
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1164 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1222
Query: 6582 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6635
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1223 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1279
Query: 6636 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6691
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1280 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1329
Query: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1330 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1386
Query: 6752 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6800
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1387 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1446
Query: 6801 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6843
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1447 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1506
Query: 6844 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6885
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1507 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1566
Query: 6886 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6915
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1567 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1626
Query: 6916 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 6962
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1627 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1686
Query: 6963 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7015
+ W + L + + K Q ED++K + E V+
Sbjct: 1687 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1735
Query: 7016 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7073
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1736 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1795
Query: 7074 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7127
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1796 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1850
Query: 7128 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7187
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1851 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1892
Query: 7188 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7247
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1893 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1937
Query: 7248 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7287
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 1997
Query: 7288 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7345
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 1998 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057
Query: 7346 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7402
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117
Query: 7403 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7461
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2176
Query: 7462 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7521
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2177 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2231
Query: 7522 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7576
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2232 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2291
Query: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7633
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2292 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2351
Query: 7634 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7691
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2352 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2409
Query: 7692 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7713
L +L ++ + L E A+
Sbjct: 2410 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2469
Query: 7714 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7767
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2470 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2525
Query: 7768 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7816
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2526 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2585
Query: 7817 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7876
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2586 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2637
Query: 7877 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 7936
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2638 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2693
Query: 7937 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 7985
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2694 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2748
Query: 7986 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8044
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2749 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2808
Query: 8045 ARDSILVWLTEMDLQLT 8061
+ +LVWL D +L+
Sbjct: 2809 SLQELLVWLQLKDDELS 2825
Score = 186 bits (472), Expect = 9e-46
Identities = 413/2178 (18%), Positives = 857/2178 (39%), Gaps = 306/2178 (14%)
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6585
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 392 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 450
Query: 6586 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6644
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 451 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 510
Query: 6645 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6690
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 511 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 570
Query: 6691 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6750
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 571 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 627
Query: 6751 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6807
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 628 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 687
Query: 6808 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6864
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 688 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 743
Query: 6865 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6923
I G + +K + + K + ++S + Q V E +D A
Sbjct: 744 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
Query: 6924 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 6975
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 802 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 851
Query: 6976 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7033
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 852 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 911
Query: 7034 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7093
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 969
Query: 7094 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7153
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 970 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1029
Query: 7154 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7213
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1030 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1085
Query: 7214 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7270
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1086 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1142
Query: 7271 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7330
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1143 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1201
Query: 7331 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7383
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261
Query: 7384 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7441
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1262 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1317
Query: 7442 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7501
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1318 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1375
Query: 7502 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7560
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1376 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1422
Query: 7561 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7617
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1423 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1473
Query: 7618 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7675
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1474 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1533
Query: 7676 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7735
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1534 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1593
Query: 7736 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7789
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1594 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1650
Query: 7790 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7849
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1651 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1699
Query: 7850 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7909
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1700 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1741
Query: 7910 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 7968
+ C +E ++ SE F + S I T A L
Sbjct: 1742 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1776
Query: 7969 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8023
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1777 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1832
Query: 8024 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8083
R+T + K +++K QQ
Sbjct: 1833 RITD--------------------------------------------ERKREEIKIKQQ 1848
Query: 8084 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8143
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1849 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1900
Query: 8144 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8203
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1901 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1956
Query: 8204 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 8263
L + + + + M+ +P E YL +S ++
Sbjct: 1957 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST---YLTEITHVSQALLE---- 2009
Query: 8264 AYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK 8323
V+ NA + D L Q L K + DS Q +II SK
Sbjct: 2010 --VEQLLNAPDLCAKDFEDLFKQEESL-KNIKDSLQQSSGRIDIIHSKK----------- 2055
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
++++ S +E +E S F +WE + +
Sbjct: 2056 ---------TAALQSATPVERVKLQEALSQLDF---------------QWEKVNKMYKDR 2091
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQK 8442
+ R ++++KW++F+ D+ WL + E+ L + Q E + K LKELQ
Sbjct: 2092 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQD 2146
Query: 8443 AVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL 8501
+ R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2147 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2206
Query: 8502 MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
F + +L LE D + +P++ + + L++ +Q+ + EL Q +
Sbjct: 2207 NILSEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGIL 2263
Query: 8562 ASLQDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL---- 8608
L + +LV+A E D LE K K + L E+ IK+L
Sbjct: 2264 KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE 2323
Query: 8609 EKLLDVSSSQQDLSSWSS 8626
+KL D+ L W S
Sbjct: 2324 KKLEDLEEQLNHLLLWLS 2341
Score = 179 bits (455), Expect = 8e-44
Identities = 534/2881 (18%), Positives = 1106/2881 (38%), Gaps = 406/2881 (14%)
Query: 5886 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 5942
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 329 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 388
Query: 5943 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6002
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 389 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 446
Query: 6003 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6060
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 447 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 494
Query: 6061 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6105
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 495 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 554
Query: 6106 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6165
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 555 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 601
Query: 6166 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6224
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 602 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 643
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6284
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 644 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 692
Query: 6285 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 693 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 741
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6391
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 742 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 801
Query: 6392 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6443
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 802 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 857
Query: 6444 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6499
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 858 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 917
Query: 6500 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6551
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 918 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 977
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6607
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 978 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1037
Query: 6608 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6667
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1038 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1093
Query: 6668 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6724
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1094 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1153
Query: 6725 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6783
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1154 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1211
Query: 6784 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6843
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1212 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1269
Query: 6844 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6903
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1270 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1318
Query: 6904 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 6963
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1319 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1378
Query: 6964 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7014
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1379 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1436
Query: 7015 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7071
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1437 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1475
Query: 7072 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1476 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1530
Query: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1531 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1587
Query: 7192 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7248
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1588 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1641
Query: 7249 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7304
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1642 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1698
Query: 7305 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7358
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1699 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1752
Query: 7359 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7417
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1753 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1810
Query: 7418 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7477
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1811 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1858
Query: 7478 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7537
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1859 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1907
Query: 7538 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7597
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1908 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1965
Query: 7598 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7647
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1966 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2025
Query: 7648 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7694
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2026 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2085
Query: 7695 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7749
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2086 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2142
Query: 7750 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7809
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2143 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2202
Query: 7810 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7869
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2203 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2260
Query: 7870 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7924
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2261 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2316
Query: 7925 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 7966
+ +L +K D + WL + F I AK+
Sbjct: 2317 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2376
Query: 7967 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8015
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2435
Query: 8016 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8064
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2436 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Query: 8065 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8123
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2496 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2555
Query: 8124 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8183
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2556 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2615
Query: 8184 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 8243
+ LA+ LR +W + D++ DL + R D D +
Sbjct: 2616 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLR-----DYSADDTR 2653
Query: 8244 DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF--- 8299
+ MI E+ A + K S +ALE R L + LD +F
Sbjct: 2654 KVH----------MITENINASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAW 2700
Query: 8300 --QIQQTENIIRSKTPTGPELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEE 8351
+ + T N+++ T L+ S K + L GE + D L+ ++
Sbjct: 2701 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2760
Query: 8352 SLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDT 8411
SL G + + + + +W L+ ++L+ ++ + +W++ + L + WL
Sbjct: 2761 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2820
Query: 8412 EEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--- 8468
++EL + + + D ++ Q + ++ + ++ +I+S F E
Sbjct: 2821 DDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE 2878
Query: 8469 ------------------SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEM 8510
+R L+ + ++N W+++ +W+ + + L + Q E
Sbjct: 2879 KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 2938
Query: 8511 SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 8570
+ L L L + K P+ +L + LQDH +++ ++ E+ + V+ + D++ Q
Sbjct: 2939 TDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQ 2997
Query: 8571 L 8571
L
Sbjct: 2998 L 2998
Score = 179 bits (453), Expect = 1e-43
Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)
Query: 5183 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5240
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 378 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 436
Query: 5241 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5299
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 437 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 489
Query: 5300 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5355
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 490 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 549
Query: 5356 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5415
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 550 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 608
Query: 5416 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5475
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 609 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 656
Query: 5476 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5535
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 657 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 694
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 695 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 749
Query: 5596 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5654
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 750 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 807
Query: 5655 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5708
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 808 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 867
Query: 5709 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 868 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 911
Query: 5769 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5821
+ V R L L P+ + + + S ++ TD +
Sbjct: 912 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 971
Query: 5822 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5879
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 972 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1031
Query: 5880 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 5936
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 1032 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1091
Query: 5937 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 5996
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 1092 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1147
Query: 5997 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6053
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 1148 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1207
Query: 6054 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6113
+L E V+A + V E L E + T + + L +L +L E+ H
Sbjct: 1208 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1265
Query: 6114 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6172
+ ++ + E + L T++ PG E E+ + L
Sbjct: 1266 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1304
Query: 6173 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6232
++L+R +I I A+T D G +++++EL + +W LH
Sbjct: 1305 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1351
Query: 6233 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6282
+E +QKLL+ ++ QE Q + ++ L+ K D Q+ + S
Sbjct: 1352 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1411
Query: 6283 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6334
L + EE+ + G + I + QK VS + E+RL +
Sbjct: 1412 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1471
Query: 6335 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6377
+L E ET QE+ L K + E+ E++ Q +
Sbjct: 1472 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1531
Query: 6378 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6437
+N +++ + L + L + V +R Q+++ L+ + ++ VL LA +
Sbjct: 1532 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1591
Query: 6438 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6497
++ A E + + + KE + + LK +V + L K + + +
Sbjct: 1592 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1646
Query: 6498 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6540
+ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 1647 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1706
Query: 6541 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6598
QK ++ K E+ + K + M RK++ + +EL +
Sbjct: 1707 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1759
Query: 6599 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6653
+A+ R K + L+ L++ ++ + LE +E+ I V L EE N+D
Sbjct: 1760 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1812
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6713
D + L + Q + + D+ KR I I L+++ N L + K
Sbjct: 1813 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1869
Query: 6714 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6768
+ H+ W +Y+ ++ DL+ L + +L + + + +EL+ ++ L
Sbjct: 1870 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1922
Query: 6769 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6815
NA ++ + + + + S Q RL T+R E + +
Sbjct: 1923 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1982
Query: 6816 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6872
+ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 1983 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2034
Query: 6873 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 6932
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++ W
Sbjct: 2035 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2081
Query: 6933 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 6990
+ + + ++ + +E W + +++ W E+ L+ Q + A + L
Sbjct: 2082 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2141
Query: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050
K +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 2142 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2198
Query: 7051 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7110
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L ++L
Sbjct: 2199 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2257
Query: 7111 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7164
++ L++ +L P + L N LK+ N++W L E+ E K
Sbjct: 2258 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2317
Query: 7165 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7216
L QL ++ +D +Q S ++ Q + N+ + D+ + E+A + D
Sbjct: 2318 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2376
Query: 7217 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7252
++L KG K+ L +L + K Q++ A AS Q
Sbjct: 2377 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2436
Query: 7253 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7310
+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 2437 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2495
Query: 7311 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7363
DL I E + + K M P L+ L L +++E + R++ +
Sbjct: 2496 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2554
Query: 7364 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7423
W + R +L L +LE E + L Q KL G Y Q+
Sbjct: 2555 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2614
Query: 7424 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7481
+ E Q RQ + + + +LL DD + ++ ++ W+ + +R
Sbjct: 2615 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2674
Query: 7482 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7540
+R ++ R Q++ EK WL E + + ++ R L D KE
Sbjct: 2675 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2730
Query: 7541 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7591
K + QG Y E +++L S + +A LQ L + KW +
Sbjct: 2731 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2790
Query: 7592 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7643
+ L W++ + + L L+ +LS+ P ++H R
Sbjct: 2791 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2850
Query: 7644 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7689
+ + V T + ++ L + L A +++ +L ++ E + +
Sbjct: 2851 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2910
Query: 7690 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7746
WE+L + +++I E L E EL L Q E GD+LI+ + +
Sbjct: 2911 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2970
Query: 7747 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7804
L+ K + EIA +EN + + +L + + L +N RW+ L +
Sbjct: 2971 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3029
Query: 7805 RVKKLKE 7811
RV++L E
Sbjct: 3030 RVRQLHE 3036
Score = 176 bits (446), Expect = 9e-43
Identities = 377/1990 (18%), Positives = 829/1990 (41%), Gaps = 261/1990 (13%)
Query: 6844 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6903
A+ EV+SW+ E+ +Q + I N + + + + ++G+ +D+ Q V ++
Sbjct: 343 ALEEVLSWLLSAEDTLQA-QGEISNDV--EVVKDQFHTHEGYMMDLTAHQGRVG----NI 395
Query: 6904 LQISSQDVESKR---SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
LQ+ S+ + + + ++T+ EQ+ +N W+ L+ EK L +L + +
Sbjct: 396 LQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK--L 453
Query: 6961 QCLKTWFETQEKRLK--QQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7017
+ L W E+R + ++ +G D ++ ++ + L++ ++ ++ V + + +
Sbjct: 454 KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV 513
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7077
++ + ++ + L+ LG WAN+ +LL+ +L +W +++L E
Sbjct: 514 DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSE 573
Query: 7078 ARYSLSRFRLLTGSLEAVQV--QVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC-HPPV 7134
++++ TG + ++ + L L+ DLEK+++S+ K S+ LL + V
Sbjct: 574 KEDAVNKIHT-TGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSV 632
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQL-QSSKALLQLWQRYKDYSKQCASTVQQQEDRTNE 7193
T+ L W+NL++++ + Q S+A+ + TV R
Sbjct: 633 TQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQI 690
Query: 7194 LLKAATNK----------------------DIADDEVATWIQDCNDLLKG---------- 7221
L+K A + D+ E+ +WI +L+
Sbjct: 691 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 750
Query: 7222 -LGTVKDSLFFLH-ELGEQLKQQVDAS-AASAIQSDQLSLSQHLCALEQA---------- 7268
+K+ + + E E+ ++ DAS +A A+ ++ + +++QA
Sbjct: 751 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIE 810
Query: 7269 LCKQQTSLQAGVLDYET----FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEE 7324
C Q S + L+Y+ F L+ LE AE L+ Q P+ S+ + I+ +++
Sbjct: 811 FC-QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ-PTTPSEPTAIKSQLKI 868
Query: 7325 LKGQMLKFSSMAPDLDRLN-------ELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERF 7377
K ++ + S + P ++RL E G D + N H+ + S R
Sbjct: 869 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN---HFKQVFSDVQARE 925
Query: 7378 SKLQSFL-----LQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL--FQ 7430
+LQ+ +++Q + TW++ Q+E KL++ + + +QR EL Q
Sbjct: 926 KELQTIFDTLPPMRYQETMSAIRTWVQ---QSETKLSIPQLSVTDYEIMEQRLGELQALQ 982
Query: 7431 AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQ 7490
+ + +Q L+ + + + ++ + ++ + + +W+ + + + ++ Q
Sbjct: 983 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1042
Query: 7491 IRQWQRYREMAEKLRKWLVEVSYL---PMSGLGSVPI---PLQQARTLFDEVQFKEKVFL 7544
+ + ++ + + L+KW+ EV LG I L+Q R L ++Q
Sbjct: 1043 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ------- 1095
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
Q S E G+++ A+ + L+ EL E+ +W ++ +K+ L L+
Sbjct: 1096 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1155
Query: 7605 EKCEKGIADSLEKLRT-----FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQ 7659
+K +++ E + ++ PD ++ E R KE + +
Sbjct: 1156 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEA------K 1209
Query: 7660 LSLLKDTLSAYIS-ADDIS--ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSE 7716
+ LL +++++ I+ A ++ L + +E L ++ LC +L+ + + + E W
Sbjct: 1210 VKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1269
Query: 7717 KNKELCEWLTQMESKVSQNGDILI-EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKA 7775
++ +WL ++E K+ +I E I ++ + + +++N Q++ + + L
Sbjct: 1270 YLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDG 1329
Query: 7776 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7835
+ I +L N RW+ L + R K L++++ + Q+ +K++ ++ L I+
Sbjct: 1330 GVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
Query: 7836 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAEC 7895
+LA I D ++ ++ + E Q++Q D+ H ++L E+ H+
Sbjct: 1388 QLAAYIA-DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK------- 1430
Query: 7896 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERT 7950
++ Q+ +D + + +SM+ +RL+QK + FE L+ S E
Sbjct: 1431 EAAQRVLSQIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVK 1478
Query: 7951 AAFPS--SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 8008
P+ + V V + +L + + E +++E++ K R++ ++ +T++ L
Sbjct: 1479 MHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELD 1538
Query: 8009 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS- 8067
+ V ++ L +VT ++L+ + + + + WL D++LT
Sbjct: 1539 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1598
Query: 8068 -ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD------------- 8110
++ +++ KA Q+EI ++ I GE L + K E L
Sbjct: 1599 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIA 1658
Query: 8111 -AAIIEEELDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----S 8161
+ EE L+ L Y + E F + V+ K +I+ DE + + + ED
Sbjct: 1659 VTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLK 1717
Query: 8162 AALSDLH-----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSI 8210
A L+D+ D++A+ + + + L +P SE + R S SI
Sbjct: 1718 AELNDIRPKVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 1774
Query: 8211 PLEWDHDYD-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVM 8257
PL+ ++ L LE+ + + + ++E+ D + G V L +
Sbjct: 1775 PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRI 1834
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------S 8310
E +K+ + ++ L SQ R+ + +Q + Q +++++
Sbjct: 1835 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1894
Query: 8311 KTPTGPEL--DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 8368
K + PE + K + L + +++V+R L E+ ++ + T+ Q +
Sbjct: 1895 KLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS- 1949
Query: 8369 VIDRWELLQAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR-- 8420
RW ++++ A + L Q + D+ +++ T E+ + +
Sbjct: 1950 --KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2007
Query: 8421 LELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR---------- 8470
LE+ + +L K ++L K + K I S+ S SK++
Sbjct: 2008 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2067
Query: 8471 -DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKN 8526
LQ+ LSQ++ +W++V + ++ +G ++ + + FH ++ + L E R+
Sbjct: 2068 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2127
Query: 8527 EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 8586
I N + + + K+L + + Q V +L +++ + TD +EK
Sbjct: 2128 ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 2180
Query: 8587 VHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRST 8644
+ + R + + K++S K LE+ ++ S Q+DL+ + +E D S+ G+
Sbjct: 2181 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 2240
Query: 8645 PNRQKTPRGK 8654
++K + K
Sbjct: 2241 QLKEKLEQVK 2250
Score = 174 bits (440), Expect = 5e-42
Identities = 447/2617 (17%), Positives = 1007/2617 (38%), Gaps = 386/2617 (14%)
Query: 1251 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1309
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 353 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 404
Query: 1310 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1362
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 405 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 463
Query: 1363 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1416
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 464 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 518
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 519 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 578
Query: 1477 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1534
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 579 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 630
Query: 1535 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 631 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 673
Query: 1594 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1653
+T +E++++ T R+ + +E Q K+R
Sbjct: 674 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 708
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1713
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 709 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 765
Query: 1714 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1768
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 766 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 823
Query: 1769 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1822
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 824 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 878
Query: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1881
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 879 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 936
Query: 1882 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1937
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 937 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 996
Query: 1938 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1997
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 997 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1056
Query: 1998 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2056
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1057 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1116
Query: 2057 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2116
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 1117 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
Query: 2117 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2175
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1233
Query: 2176 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2235
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 1234 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1289
Query: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2295
N E + E ++N E+ +++ L + + +L E +
Sbjct: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1349
Query: 2296 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2354
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 1350 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1404
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 1405 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1461
Query: 2415 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 1462 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1519
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 1520 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1579
Query: 2535 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2576
W+ E+ +R E + G++ Q EK+ + +V L +L
Sbjct: 1580 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1639
Query: 2577 ARESL--DKLS------------------------------------------QRGQLLS 2592
+E+L DKLS Q LL
Sbjct: 1640 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1699
Query: 2593 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2646
E Q+ + L + N +R T+++ + +H + +E + +
Sbjct: 1700 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1759
Query: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2692
AI R+ ++++ K+ LE+ S IQ LL E E++ + +
Sbjct: 1760 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1817
Query: 2693 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2744
G ++ L+ + QR+ + ++ ++ + +A L S + QW
Sbjct: 1818 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1877
Query: 2745 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2798
Y + + L + ++ +++K+ +P+ K K + + L ++ +AE +
Sbjct: 1878 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1937
Query: 2799 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2858
+ + ++ + + + F I TV +E M + E + + Y+ + +
Sbjct: 1938 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 1996
Query: 2859 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2912
T+ H ++ E+L D+ + D K+ +K + DS + + R+ + S
Sbjct: 1997 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2056
Query: 2913 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2972
Q+ T + + L W++ V++M Q G+ +
Sbjct: 2057 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2098
Query: 2973 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3026
+ +F +K + Q LT E +I E W +E+ D + + + L
Sbjct: 2099 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2158
Query: 3027 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3081
+ E+ + S D S K+ L + +C Q S K + ++ IL + F++
Sbjct: 2159 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2217
Query: 3082 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3139
+F WL A + + P ++ L++++ + E Q L + G L+S
Sbjct: 2218 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2276
Query: 3140 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3192
++ E+ ++ K+ W L +K+ +E L+ +++D E +
Sbjct: 2277 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2336
Query: 3193 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3252
WLS + +Y+ P + +Q + +P + + K Q L++ +
Sbjct: 2337 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2390
Query: 3253 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3291
A++ + ++ LSS++ A++ L +E ++ L I A Q
Sbjct: 2391 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2450
Query: 3292 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3331
F+ EL DW++ ++ S D ++ +K +
Sbjct: 2451 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2510
Query: 3332 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3390
A + +++ Q++ ++T +++ TS + T I +++ +++ W + + Q
Sbjct: 2511 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2570
Query: 3391 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3433
L L ++W ++ Q G W +D+++ + E+++ +LR
Sbjct: 2571 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2630
Query: 3434 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3493
T + A L ++L S +T +V H +T +++ +R+I +R E
Sbjct: 2631 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2679
Query: 3494 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3530
E+ RL Q++ DL+ F WL + + E + Q+ L+G
Sbjct: 2680 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2739
Query: 3531 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3590
+ H +L E Q +L S+ + + V+ R L+++ W +
Sbjct: 2740 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2786
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3627
+ R+ ++ + + Q++ WL+ +++
Sbjct: 2787 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 2823
Score = 167 bits (423), Expect = 4e-40
Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)
Query: 4070 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4124
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 346 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 403
Query: 4125 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4178
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 404 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 463
Query: 4179 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4238
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 464 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 507
Query: 4239 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4298
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 508 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 548
Query: 4299 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
LL D L L +Q L + + + + + + + + LS
Sbjct: 549 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 595
Query: 4359 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4417
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 596 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 650
Query: 4418 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4477
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 651 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 701
Query: 4478 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4536
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 702 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 761
Query: 4537 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4591
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 762 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 821
Query: 4592 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4651
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 822 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 875
Query: 4652 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4706
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 876 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 935
Query: 4707 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4760
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 936 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 991
Query: 4761 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4820
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 992 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1051
Query: 4821 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4880
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 1052 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 4997
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 1172 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1229
Query: 4998 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5057
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1284
Query: 5058 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5112
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 1285 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1338
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 1339 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1398
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
A++ ++ Q L +S L++ G+E Q + + D
Sbjct: 1399 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1442
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5284
+ V +L ++ E ++ K + E K +L P +E + +
Sbjct: 1443 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1496
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5344
QL L + + +E + + ++ T P EL ++ + L +++
Sbjct: 1497 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1553
Query: 5345 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5400
K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 1554 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1609
Query: 5401 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5450
K +E K + + G+ LGK KL+ L+ I +AE L+
Sbjct: 1610 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1669
Query: 5451 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5510
L + H+E +++ ++ I KWI +A L + Q +E + + L E +I
Sbjct: 1670 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1725
Query: 5511 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5567
++++ ++ L + +C + + Q++EL + IK ++ K++++F
Sbjct: 1726 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1783
Query: 5568 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5618
++++KL LE Q L + + ++ + LL ++L+ ++ + +
Sbjct: 1784 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1843
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5678
++ Q L+ + + L + +++A + H Q + + E+++
Sbjct: 1844 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1898
Query: 5679 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5731
L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++ +
Sbjct: 1899 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1957
Query: 5732 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5791
K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 1958 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2008
Query: 5792 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5851
E +++P C ++I S+ R+ IH +A+
Sbjct: 2009 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2059
Query: 5852 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5911
+ P L L WE + + ++Q ++E+ +++ ++ + +
Sbjct: 2060 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2119
Query: 5912 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 5965
E L ++ P + EH + LQD I + Q ++ EE++ +S + D
Sbjct: 2120 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2173
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ L L R + + S +++ LEE Q+ L ++ + +E
Sbjct: 2174 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2220
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 2221 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2279
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6143
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q +
Sbjct: 2280 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2338
Query: 6144 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6200
WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 2339 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2386
Query: 6201 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6260
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 2387 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2422
Query: 6261 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6320
L G+ G PTQ + VT + A ++ S S+ LE +
Sbjct: 2423 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2475
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
T L D L + + +Q ++ D+++++E + K K
Sbjct: 2476 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2515
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ QR Q++E + N +N TS + + II
Sbjct: 2516 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2546
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
++IE IQ D ++E LQ + + E+ K
Sbjct: 2547 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2576
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6558
Q L K + E+ L LE+ +E G + K+ E +QL
Sbjct: 2577 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2625
Query: 6559 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6618
+++ ++ L L R + +K + A ++ KR +R LE E
Sbjct: 2626 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2682
Query: 6619 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6669
T L + +L + L + + + ++++ ++RL+ + + +Q L+ +
Sbjct: 2683 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2742
Query: 6670 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6725
+ + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 2743 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2802
Query: 6726 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6785
W R +L+ WLQ D L + + + V+ + F +E+ + +
Sbjct: 2803 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2858
Query: 6786 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6824
S L T L + ++ T LR + ++++W L +
Sbjct: 2859 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2918
Query: 6825 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6884
Q K+ + +++L ++ + + L + + K + ++ ++L+K K
Sbjct: 2919 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2976
Query: 6885 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 6944
+ +I + V VN Q+++ ++ + + + +N W++LQ V ++++
Sbjct: 2977 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3032
Query: 6945 LL 6946
L
Sbjct: 3033 QL 3034
Score = 162 bits (409), Expect = 2e-38
Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)
Query: 607 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 659
E +S S L E N DRY + + +WL AE L N E K F + +
Sbjct: 322 EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 381
Query: 660 WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 708
+ GN L E ++++Q+ LLN RW R ME +
Sbjct: 382 MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 441
Query: 709 QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 761
MD ++ + L+ K EPL ++K +Q DLE +
Sbjct: 442 HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 501
Query: 762 RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 804
RV + ++ +++ + +E+ K + +A + + E +LT
Sbjct: 502 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 561
Query: 805 KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 863
+ + +S L E + + + K SL K+ + LE++ QS Q
Sbjct: 562 EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 621
Query: 864 ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 906
+LL+ +N T + +EK + + + VT + QT +
Sbjct: 622 DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 679
Query: 907 QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 958
+ + Q +VK + K+ + +S + K+ + EL + ++ L+
Sbjct: 680 TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 739
Query: 959 EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 1002
PE + R FS L ++V NA L+ L EQ
Sbjct: 740 S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 795
Query: 1003 GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1059
+++A +L+ +W + L E L + + L +E+ T + K+ P
Sbjct: 796 SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 855
Query: 1060 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1118
SE IK D+ RL ++ +L ++ G + L A
Sbjct: 856 PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 909
Query: 1119 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1165
+ ++++ D + Y S +W+ +ET+L + D
Sbjct: 910 FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 969
Query: 1166 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1225
+ ++ +++ + ++ L +L + +K +++ + ++K E ++ +K L
Sbjct: 970 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1029
Query: 1226 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1278
+ L E +E+ ++ + + +K + E+ ++E+ + D+E L +
Sbjct: 1030 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1086
Query: 1279 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1338
+LL+ Q + + Q+I + E R EL++L + D + + +
Sbjct: 1087 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1144
Query: 1339 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1398
+ ++ L K + + + ++ Q + E +L EL++ E KR +
Sbjct: 1145 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1201
Query: 1399 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1452
A Q E VK +E P ++ L+++ +++ + L L KT+E V
Sbjct: 1202 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261
Query: 1453 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1512
W S E + W+ E E +L E + +I + +E+ +
Sbjct: 1262 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1317
Query: 1513 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1570
+ + AQ +T G I +L EL E A + + + Q+ E++L
Sbjct: 1318 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1377
Query: 1571 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1613
IQ+S++ + +LA I KI S T + + +++H +A + +
Sbjct: 1378 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1437
Query: 1614 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1670
S I + V + Q+ A +Q+ ++ IL K ALE + ++ +
Sbjct: 1438 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1497
Query: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
L+ + + S EM I R Q++Q Q E +
Sbjct: 1498 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1538
Query: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1790
+ V +KLH +L + + Q + K + + + E E W+
Sbjct: 1539 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1585
Query: 1791 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
EL S + M + A ++ + E++ + HL + +G A L +
Sbjct: 1586 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1638
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1908
GK E L E+ ++ +A+ S E+L + Q V+ T + + +
Sbjct: 1639 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1695
Query: 1909 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1968
+ L E + Q L+ L+ I K + +Q + A C
Sbjct: 1696 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1745
Query: 1969 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2026
+ L+ + SE + A + + K + LK +E +D ++L EP +QQ +
Sbjct: 1746 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1802
Query: 2027 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2080
+ FN +D +E + L + + Q+ D E+ + L+ + K L
Sbjct: 1803 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1860
Query: 2081 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ + + + +Y+ + K L++ + + +D+ +K + + K
Sbjct: 1861 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1920
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2184
++N ++ + + G + E +I S +F+ + T E T+
Sbjct: 1921 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1978
Query: 2185 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2243
+ ++E + + + L+ V E+E N P + + ++ + EE
Sbjct: 1979 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2033
Query: 2244 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2303
LK + ++ + R++ +HSK K TP + ++ L Q +++ ++ K
Sbjct: 2034 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2089
Query: 2304 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2357
F + +F DI W T+ E+ L E E K +K++Q +
Sbjct: 2090 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2149
Query: 2358 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2415
+Q+ + + + ++ + L + L ++ E QL K + Q+++
Sbjct: 2150 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2209
Query: 2416 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2475
F + EF W A A + G + L+ KL ++ +++ + Q L + +
Sbjct: 2210 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2268
Query: 2476 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2533
G + A +S + ++ ++ + N Q +K +AL + E+ +
Sbjct: 2269 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2314
Query: 2534 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
++LG+ ++ + + + +++ + ++L + E ++ +Q G +
Sbjct: 2315 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2362
Query: 2594 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2649
E A Q + ++L+ Q+L + T+ R + E +A+ LQ + +A
Sbjct: 2363 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2418
Query: 2650 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2707
Q LA +T+G+ T + ++ + ++ K KL M ++ AL N+
Sbjct: 2419 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2476
Query: 2708 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2767
+ W ++ + +Q + + N+ + ++ Q +E
Sbjct: 2477 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2517
Query: 2768 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2827
Q +P L+E +L++ S E T R+ E ++ Q
Sbjct: 2518 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2556
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
++++ + + +++ E++KD +L+A E L A+ +L W + A QKK+
Sbjct: 2557 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2616
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2947
++ K+L + + LA ++ ++ +A +H + + A W+ V +
Sbjct: 2617 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2676
Query: 2948 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 3004
++ LE L+ Q L ++F +A L +A E + +L+ ++ LLE +E+++
Sbjct: 2677 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2732
Query: 3005 CWHKGQEILDA 3015
W Q ++A
Sbjct: 2733 QWQDLQGEIEA 2743
Score = 159 bits (402), Expect = 1e-37
Identities = 580/3108 (18%), Positives = 1159/3108 (37%), Gaps = 547/3108 (17%)
Query: 2753 EQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTE 2812
+Q S+ Q E P+P +F + Q+ D TR+ S+ L E E
Sbjct: 272 QQITVSLAQGYERTSSPKP----RFKSYAYTQAAYVTTSDPTRSPF----PSQHL-EAPE 322
Query: 2813 DESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2872
D+SF + E + + T +E + + L A E ++ + K++ H
Sbjct: 323 DKSFGSSLMES-EVNLDRYQTALEEVLSWLLSAEDT----LQAQGEISNDVEVVKDQFHT 377
Query: 2873 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQA 2932
D +A Q ++ I +L S+ IG +LS E + + N L+++ +
Sbjct: 378 HEGYMMDLTAHQGRVGNILQL-GSKLIGTGKLSEDEETEVQEQMN-------LLNSRWEC 429
Query: 2933 LRADWKQWEDSVFQTQSCLENLVSQ-------------MALSEQEFSGQVAQLEQALEQF 2979
LR + + ++ + L+N + + E+ + L++ ++Q
Sbjct: 430 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 489
Query: 2980 SALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRD 3039
L + Q+ + T +V G AL E + + L + +CR++ D
Sbjct: 490 KVLQEDLEQEQVRVNSL-THMVVVVDESSGDHATAAL---EEQLKVLGDRWANICRWTED 545
Query: 3040 ----LSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTA 3095
L K L +E CL S KE + + F+D
Sbjct: 546 RWVLLQDILLKWQRLTEE-QCLF---SAWLSEKEDAVNKIHTTGFKD------------- 588
Query: 3096 KCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLS-KGELLSTLLTKEKAKGIQAKV 3154
QN E+ +SLQK+ ++ E + + + S K +LLSTL K K + K
Sbjct: 589 ------QN--EMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL----KNKSVTQKT 636
Query: 3155 TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3214
A +++ NL QK LE Q+ + +P S T+ V E+ +
Sbjct: 637 EAWLDNFARCWDNLVQK---LEKSTAQISQAVTTTQP-----SLTQTTVMETVTTV---- 684
Query: 3215 AKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNL 3274
REQ ++ EE+ PQ R Q S +
Sbjct: 685 -TTREQILVKHAQEELPPPPPQKKR---------------------------QITVDSEI 716
Query: 3275 TKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDS--YCHPTSDKSVLDSRTLKLEA 3332
K RLD + I EL W+T + +L S + + + D + K+ A
Sbjct: 717 RK----RLD----------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE-KVNA 761
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGI--PTIQQQLQSVKDMWASLLSAGIRCKSQ 3390
+ K EK +++ +++++ EG+ +I+Q + + W Q
Sbjct: 762 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC--------Q 813
Query: 3391 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESER----QHAELRDKTTMLGKAKLLNEEV 3446
L W YQ+ + F + +E +E Q + T + + K+ +EV
Sbjct: 814 LLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEV 873
Query: 3447 LSYSSL---LETIEVKGAGMTEHYVTQLELQ--------DLQERYRAIQERAKEAVTKSE 3495
S L +E ++++ + E + L ++ + +Q R KE T +
Sbjct: 874 NRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD 933
Query: 3496 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA- 3554
L + YQ + A W+ Q + KL + D E L +LQ LQ E Q+
Sbjct: 934 TLPPMR--YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSG 991
Query: 3555 --LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3612
L++ + PS I + E + W+ +L E + +NKLR ++
Sbjct: 992 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1051
Query: 3613 KFQQVDEWLKTAE---EKKWH-------------------EEVTAYRDEVEEVGARAQEI 3650
Q + +W+ + +++W ++ + + V Q+I
Sbjct: 1052 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1111
Query: 3651 LDESHVN--SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3708
+E+ SR+ + +L +++ + QV + + L+ ++ + LS +W
Sbjct: 1112 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1171
Query: 3709 THKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA 3768
+ + + + KT + L K +E+ +K A+E+ ++ +E +
Sbjct: 1172 AEEEY------------LERDFEYKTPDELQKAVEE----MKRAKEEAQQ-----KEAKV 1210
Query: 3769 ERLRKEIHDHMEQLKELTS-TVRKEHMTLEKGLH-LAKEFSDKCKALTQWIAEYQEILHV 3826
+ L + ++ + Q + ++KE TL L + KCK L + A + E+L
Sbjct: 1211 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1270
Query: 3827 PEEPKMELYEKKAQLSKYK--------------SLQQTVLSHEPSVKSVREKGEALLEL- 3871
E+ L E + +L + SL+ + E + +R + L +
Sbjct: 1271 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1330
Query: 3872 VQDVTLKDKIDQLQSDYQDLCSIG----KAMMEEIAGFEDRLNNLQMKGDTLI------- 3920
V D + ++++ S +++L K + + I ++ +L + ++L
Sbjct: 1331 VMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA 1390
Query: 3921 GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAW 3980
AD + A +Q S+ SLE E++KH ++ Q+ +
Sbjct: 1391 AYIADKVDAAQMPQEAQKIQSDLTSHEI----------SLE-EMKKHNQGKEAAQRVLSQ 1439
Query: 3981 LSAVQPDLEPSP------QPPLSRAEAIKQVK--------HFRAL------QEQARTYLD 4020
+ Q L+ Q P + + +++ K H AL QE ++ L+
Sbjct: 1440 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1499
Query: 4021 LLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQD 4077
C S + VK+ + + +T + I QK Q +N + E + LK +EL + +
Sbjct: 1500 H-CVNLYKSLSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTE 1557
Query: 4078 ADQQLQNMKR--RHSELELNIAQNMV----------SQVKDFVKKLQSKQA--------- 4116
QQL+ + R E+N+ + S V+ L S+ A
Sbjct: 1558 RKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEI 1617
Query: 4117 --------SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDL 4165
S+ + E + + K+E+ +++ LN W+ + ++ NL L+ ++ +
Sbjct: 1618 EKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHM 1677
Query: 4166 QRTRDYHDCMNVVEVFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ D + K+ + D L S+ + + LK+L L + + ++
Sbjct: 1678 ETFDQNVD-------HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDST 1730
Query: 4225 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQ 4283
+DQ ++ + ++LV+ Q S L R+ + IK K + + LE+ N +
Sbjct: 1731 RDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLL 1790
Query: 4284 ELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4343
E +E +Q N+ E D +++ D+ EL + L+ I D
Sbjct: 1791 EPLEAEIQQGVNLKEE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE------ 1837
Query: 4344 LGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER 4403
+R+ I+ Q+ N L DL QRRK KAL Q+ QA ++ +
Sbjct: 1838 ---RKREEIKIKQQLLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD 1891
Query: 4404 KIMFREHICLLPDD-----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEK 4458
+ + LP+ + + + + + L + + GL G + E T+ +
Sbjct: 1892 ---IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 1948
Query: 4459 SEVLGKLQELQSVYDSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWL 4507
S+ +++ + + + H ++E LE + V + E + L
Sbjct: 1949 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2008
Query: 4508 KQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDH 4567
+ ++ P++ + +L Q +NI + + + + L S V+
Sbjct: 2009 EVEQLLNAPDL-CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2067
Query: 4568 SYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMS 4627
L E L+ L Q+ + + KD+ + ++ + + I++ Q L+E E QFLR +
Sbjct: 2068 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKT 2126
Query: 4628 KVPTDLAVEE----ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4683
++P + + LQDG V L +E+ Q+ T +K+
Sbjct: 2127 QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGS 2183
Query: 4684 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEK 4743
L + + +Q R LE+ + E ++ + L+ N ++P E
Sbjct: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP- 2236
Query: 4744 LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4803
G Q L++V + +E+L PL + Q+ G + + E
Sbjct: 2237 --------GKEQQLKEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPE 2282
Query: 4804 TVTECESRMVQSIDFQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE 4862
+ E+++ Q+ ++SR+L + ++A++ L+ L+D++E++ + +
Sbjct: 2283 EQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSP 2342
Query: 4863 VQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTE 4919
+++ L I N + E D+QE A++ +Q + E
Sbjct: 2343 IRNQLEIYNQPNQ-------------------------EGPFDVQETEIAVQAKQPDVEE 2377
Query: 4920 IYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNL 4978
I S+ Q Y+ + A + +K +E S+E + L
Sbjct: 2378 ILSKGQHLYKE------------------------KPATQPVKRKLEDLSSEWKAVNRLL 2413
Query: 4979 EELHSLVATLDPLIKPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5032
+EL + L P + G + Q V + E ++ S +++
Sbjct: 2414 QELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA---- 2469
Query: 5033 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALE 5092
D+ +A E+ + ++ ++ + ++ + E + + KA + + ++ L
Sbjct: 2470 -DFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2527
Query: 5093 EKASQLE-KTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKK 5151
A L+ KT N ++ ++ + + +W ++ Q++ + L + + + T + ++
Sbjct: 2528 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2587
Query: 5152 ATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDG 5211
A +++ Q + KL + + + +L Q Q+ + + L +L+D
Sbjct: 2588 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2647
Query: 5212 AAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQET 5271
+A ++ + IT E + + + + + + +RE ++ET
Sbjct: 2648 SA----DDTRKVHMIT----------ENINASWRSIHKRVSEREAA----------LEET 2683
Query: 5272 KEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5331
L + LE+ LTEA ++ +++ L E
Sbjct: 2684 HRLLQ----QFPLDLEKFLAWLTEAETTANVLQDATRKER-----------------LLE 2722
Query: 5332 VALDLK-IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
+ +K + Q QD E+E L QK+ + L + D
Sbjct: 2723 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDD 2767
Query: 5391 QKVLGEELDGCNSKLMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5447
+L LD N K EL ++ LE + K L + +L + Q +R
Sbjct: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSR 2826
Query: 5448 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKE 5507
+ + +++ N++ + ++ + + T+ + + L +E +E
Sbjct: 2827 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 2886
Query: 5508 IDSELEA--MTEKLQYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK-- 5561
+ E A +T L+ T EK++ A+ R+ +E + RLQ LQ+A
Sbjct: 2887 LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDEL 2942
Query: 5562 DMKKFEAELKK-------------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSE 5607
D+K +AE+ K LQ LE+ +A G ++ LKE +SH L +
Sbjct: 2943 DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQ 2997
Query: 5608 MESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5655
+ +L +QL L ED+ L A+ E+ R H A
Sbjct: 2998 LTTL-----GIQLSPYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3037
Score = 157 bits (397), Expect = 4e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 5449 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5506
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 328 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 383
Query: 5507 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5565
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 384 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 440
Query: 5566 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5624
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 441 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 495
Query: 5625 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5684
L ++ V L H + + E + A+ E+++K L
Sbjct: 496 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 537
Query: 5685 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5731
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 538 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 597
Query: 5732 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5785
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 598 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 649
Query: 5786 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5845
L E+S ++IS PS T + + + + Q + P
Sbjct: 650 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 703
Query: 5846 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5905
Q + + + +L SW T + + + ++ + D +
Sbjct: 704 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 756
Query: 5906 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 757 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 795
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 796 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 839
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 840 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 899
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6145
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 900 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 943
Query: 6146 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6193
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 944 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1003
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6224
+ + K +E+ +K S+ E+QM
Sbjct: 1004 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1063
Query: 6225 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6280
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1064 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1123
Query: 6281 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6335
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1124 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1183
Query: 6336 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1184 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1240
Query: 6392 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6435
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1241 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1300
Query: 6436 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6493
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1301 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1344
Query: 6494 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6553
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1345 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1400
Query: 6554 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6613
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1401 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1454
Query: 6614 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6673
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1455 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1513
Query: 6674 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6730
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1514 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1573
Query: 6731 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6786
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1574 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1625
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1626 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1685
Query: 6847 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6906
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1686 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1737
Query: 6907 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 6965
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1738 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1791
Query: 6966 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7016
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1792 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1851
Query: 7017 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7071
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1852 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1911
Query: 7072 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7126
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1912 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1966
Query: 7127 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7185
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1967 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2015
Query: 7186 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7245
A D A +D + L +KDSL + + + A
Sbjct: 2016 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2057
Query: 7246 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7298
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2058 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2117
Query: 7299 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7356
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2118 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2177
Query: 7357 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7412
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2178 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2234
Query: 7413 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7469
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2235 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2294
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7529
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2295 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2354
Query: 7530 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7589
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2355 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2412
Query: 7590 LEEQKKKLAFL--------------------------------------------LKDWE 7605
L+E + K L L D+
Sbjct: 2413 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2472
Query: 7606 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7662
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2473 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2532
Query: 7663 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7722
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2533 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2589
Query: 7723 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7778
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2590 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2649
Query: 7779 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7838
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2650 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2707
Query: 7839 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7891
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2766
Query: 7892 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 7951
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2767 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2824
Query: 7952 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 7992
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2825 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2884
Query: 7993 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2885 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2940
Query: 8052 WLTEMDLQLTNIE 8064
E+DL+L E
Sbjct: 2941 ---ELDLKLRQAE 2950
Score = 135 bits (341), Expect = 1e-30
Identities = 421/2275 (18%), Positives = 879/2275 (38%), Gaps = 333/2275 (14%)
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
Q L SR++ L + +E+ L + L+ + L +DW T + + + +
Sbjct: 419 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLG 476
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3782
D + ++++ +VL +D+E+ + S V ++E + + + ++ L
Sbjct: 477 PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM----VVVVDESSGDHATAALEEQLKVL 532
Query: 3783 KELTSTVRK----EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK 3838
+ + + + + L+ L + +++ + W++E ++ ++ K+ K
Sbjct: 533 GDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVN-----KIHTTGFK 587
Query: 3839 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV--TLKDKIDQLQSDYQDLCSIGK 3896
Q SLQ+ + K + G+ L L QD+ TLK+K +++
Sbjct: 588 DQNEMLSSLQKLAVLKADLEKKKQSMGK-LYSLKQDLLSTLKNKSVTQKTE--------- 637
Query: 3897 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
A ++ A D L K I Q Q L Q ++ + + + Q +
Sbjct: 638 AWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT------VMETVTTVTTREQIL 691
Query: 3957 YQSLEHELQK---HVSRQDTLQ------------QCQAWLSAVQPDLEPSPQPPLSRAE- 4000
+ + EL RQ T+ + +W++ + L+ SP+ + R E
Sbjct: 692 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ-SPEFAIFRKEG 750
Query: 4001 ----------AIKQVK--HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4048
AI++ K FR LQ+ +R+ L+ M + A I+Q + +
Sbjct: 751 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEG-----VNADSIKQASEQLN 805
Query: 4049 QKLVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMK-----RRHSELELNIAQNM 4100
+ ++ L W E ++ + LQ +Q + + + E ++
Sbjct: 806 SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQ 865
Query: 4101 VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI------NHLNDQWLDLCRQS 4154
+ KD V +L Q + + + L +K + P + NH + D+ Q+
Sbjct: 866 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDV--QA 923
Query: 4155 NNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWD--NLARSDAESTAVHLEALKKLAL 4212
LQ D Y + M+ + ++++ T+ L+ +D E L L+ L
Sbjct: 924 REKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 983
Query: 4213 ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNL 4272
+LQE++ + L ++M + + + + +E RW +L + Q +
Sbjct: 984 SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1043
Query: 4273 EELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
+L +Q+ Q L +W E + E ++ + L + S+++ Q L S
Sbjct: 1044 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1103
Query: 4333 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4392
+ + ++ + ++ L + + + + V R++ L L + +
Sbjct: 1104 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1163
Query: 4393 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA-------QASLKTYQNEVTGLWAQ 4445
+ + Q E + + R+ PD++ K V+ K A +A +K V + AQ
Sbjct: 1164 EMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQ 1223
Query: 4446 GRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACH 4505
+ +E ++E L+ L + Y + + + + + LE+ +KA
Sbjct: 1224 APPVAQEALKKE-------LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANK 1276
Query: 4506 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEV 4565
WL + + N+ + E+ L +N++ S + N + L +T
Sbjct: 1277 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT---------LT 1327
Query: 4566 DHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLR 4625
D + E +N FN ++ ++ E + R++ L+E + QS E E
Sbjct: 1328 DGGVMDELINEELETFN-------SRWRELHEEAVRRQK---LLEQSIQSAQETEKSL-- 1375
Query: 4626 MSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLV 4685
++E+L+ D A A + + VD +E Q Q D H +
Sbjct: 1376 -------HLIQESLTFIDKQLA-----AYIADKVDAAQMPQE-----AQKIQSDLTSHEI 1418
Query: 4686 TLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK 4745
+L ++H + + +R L + Q K+ + ++ K +
Sbjct: 1419 SL-------------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM----KFR 1455
Query: 4746 MYHSLAG---SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4802
++ A LQ+S ++L V +HL P L+ + E + +QS L ++
Sbjct: 1456 LFQKPANFEQRLQESKMILDEVKMHL----PALETKSVE--QEVVQSQLNHCVNLYKSLS 1509
Query: 4803 ETVTECE------SRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKI 4856
E +E E ++VQ QTE + LD RV A L L+ ++ K+
Sbjct: 1510 EVKSEVEMVIKTGRQIVQK--KQTENPKELD--ERVTA-------LKLHYNELG---AKV 1555
Query: 4857 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDG---DIQEALRTR 4913
+++++ L++ + KE + L + D+E L + S ++G ++ +
Sbjct: 1556 TERKQQLEKCLKLSRKM---RKEMNVLTEWLAATDME--LTKRSAVEGMPSNLDSEVAWG 1610
Query: 4914 QATLTEIYSQ---CQRYYQVFQAANDWLEDAQELLQ-----LAGNGLDVES-AEENLKSH 4964
+AT EI Q + +V +A L + L++ L N + V S AEE L
Sbjct: 1611 KATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1670
Query: 4965 MEFFSTEDQFHSNLEELHSLVATLDPLI------KPTGKEDLEQKVASLELRSQRMSRDS 5018
+E+ + F N++ + + D L+ KP KED+ +++ + EL R DS
Sbjct: 1671 LEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKA-ELNDIRPKVDS 1729
Query: 5019 GAQVDLLQRCTAQWHDY-QKAREEVIELMNDTEKKLSEFSLLKTSSS----HEAEEKLSE 5073
D A D+ +K E I +N +S +KT + E E+ S+
Sbjct: 1730 TR--DQAANLMANRGDHCRKLVEPQISELNHRFAAISH--RIKTGKASIPLKELEQFNSD 1785
Query: 5074 HKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSM---TTVWQRWT--RLRAVA 5128
+ L+ + + ++ V L+E+ K N+ ++ T+ + + QR T R R
Sbjct: 1786 IQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1843
Query: 5129 QDQEKILE------------------DAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEK 5170
+ ++++L+ + +W + + + +D ++ KL S E
Sbjct: 1844 KIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL-ASLPEP 1902
Query: 5171 ASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAA----PTPGEEPPLMQEI 5226
+ ++ + EL++++ L +R+Q + +DGAA PT + +EI
Sbjct: 1903 RDERKIKEIDR-------ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI 1955
Query: 5227 TA--MQDRCLNMQE--KVKTNGKLVKQELKDREM------VETQINSVKCWVQETKEYLG 5276
+ Q R LN + V+ +V E E+ T+I V + E ++ L
Sbjct: 1956 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 2015
Query: 5277 NPTI---EIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE-LSLQLAEV 5332
P + + + ++ + L + +Q+ ++ +K L + P E + LQ A
Sbjct: 2016 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2075
Query: 5333 ALDL---KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT---DNVVQ 5386
LD K+ +D+ ++S + I K+ T + KT +N
Sbjct: 2076 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEH 2134
Query: 5387 AKTDQKVLGEELDGCNSK---LMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTIR 5442
AK + L E DG + + L+A ++ ++Q+ + L +K+G L Q+ +
Sbjct: 2135 AKY-KWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2193
Query: 5443 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5502
Q +R +L + + L E+ L + W+E+A +A + QL+E+ + L+
Sbjct: 2194 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2253
Query: 5503 EESKEIDSELEAMTEK-----LQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQ 5557
EE L+ + E + S +K+ ++ + + ++ + + + ++
Sbjct: 2254 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2313
Query: 5558 DAAKDMKKFEAELKKLQAALE-------------------------QAQATLTSPEVGRL 5592
KD+ + E +L+ L+ L Q T + + +
Sbjct: 2314 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2373
Query: 5593 SLKEQLSHRQHLLSE----------MESLKPKVQAVQLCQSALRIPE-DVVASLPLCHAA 5641
++E LS QHL E +E L + +AV LR + D+ L A+
Sbjct: 2374 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2433
Query: 5642 ----LRLQEEASRLQHTAIQQCNIMQAAVVQ---YEQYEQEMKHLQQLIEGAHREIEDKP 5694
+ L + + TAI + + + +++ + + L + + I+ +
Sbjct: 2434 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2493
Query: 5695 VATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749
V +++++ I + + Q ++ + Q+ L + + L K + +T+
Sbjct: 2494 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD 2548
Score = 129 bits (323), Expect = 2e-28
Identities = 269/1454 (18%), Positives = 572/1454 (39%), Gaps = 260/1454 (17%)
Query: 7259 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7318
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 315 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 371
Query: 7319 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7370
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 372 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 431
Query: 7371 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7428
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 432 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 491
Query: 7429 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7484
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 492 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 547
Query: 7485 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7544
++ + +WQR E WL E D V
Sbjct: 548 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 586
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 587 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 643
Query: 7605 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7664
+C + LEK ++ AV + LTQ +++
Sbjct: 644 ARCWDNLVQKLEK------------------------STAQISQAVTTTQPSLTQTTVM- 678
Query: 7665 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7724
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 679 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 723
Query: 7725 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQE--NKIQLQQMGERLAKAS 7776
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 724 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 783
Query: 7777 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKL--KETLVA----VQQLDKNMS 7824
E +E I+ ++N RW L++ R+ L + ++A +QQL++ +
Sbjct: 784 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 843
Query: 7825 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7884
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 844 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 894
Query: 7885 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 7944
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 895 EKGQGPMFLDADFV-AFTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 951
Query: 7945 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8004
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 952 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1011
Query: 8005 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNI 8063
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1012 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1071
Query: 8064 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8122
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1072 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1131
Query: 8123 ----RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSL 8177
CQ+V+ R E L ++ + L+ LS++H W ++ +
Sbjct: 1132 TQWDHMCQQVYARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEY 1176
Query: 8178 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
LE D +Y +L+ A+ +++E
Sbjct: 1177 ----------------------------------LERDFEYKTPDELQKAVEEMKRAKEE 1202
Query: 8238 EGQDDKDFYLRGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE--- 8284
Q + L ++ V+ P + EA K E N +G LE
Sbjct: 1203 AQQKEAKVKLL-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1261
Query: 8285 -------SQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8337
S + + K L++ F+++ TENI P G E E S +D
Sbjct: 1262 ACWHELLSYLEKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLD 1303
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKEL 8385
S LE+ ++ E++ P + + + GV+D RW L +A+ ++
Sbjct: 1304 S---LENLMRHSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQK 1359
Query: 8386 RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD 8445
++Q++Q Q +TE+ L +Q D Q K+ Q +
Sbjct: 1360 LLEQSIQSAQ--------------ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1405
Query: 8446 HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8505
+K + +L S E + + K+ +Q RV S ++ + LQD M+ +
Sbjct: 1406 AQK---IQSDLTSHEISLEEMKKH-------NQGKEAAQRVLSQIDVAQKKLQDVSMKFR 1455
Query: 8506 GFHEMSHGLLLMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRV 8561
F + ++ + E+ +D K + +++ +++ E++Q + + L E + V
Sbjct: 1456 LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV 1515
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD- 8620
+ Q++ + + E E+V + L +V+ ++LEK L +S +
Sbjct: 1516 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1575
Query: 8621 ---LSSWSSADELD 8631
L+ W +A +++
Sbjct: 1576 MNVLTEWLAATDME 1589
Score = 119 bits (298), Expect = 1e-25
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 528 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 578
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 945 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1004
Query: 579 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 638
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 1005 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
Query: 639 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 685
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 1063 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1122
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 741
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 1123 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1176
Query: 742 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 1177 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1229
Query: 797 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 856
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1282
Query: 857 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 915
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 1283 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1328
Query: 916 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 975
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 1329 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1383
Query: 976 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1031
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 1384 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1440
Query: 1032 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1441 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1491
Query: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1138
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1492 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1546
Query: 1139 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1195
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1547 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1603
Query: 1196 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1252
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1604 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1663
Query: 1253 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1299
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1664 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1723
Query: 1300 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1359
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1724 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1774
Query: 1360 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1418
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1775 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1829
Query: 1419 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1469
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1830 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1889
Query: 1470 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1521
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1890 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1947
Query: 1522 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1575
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1948 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2007
Query: 1576 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1628
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 2008 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2066
Query: 1629 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1688
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 2067 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2126
Query: 1689 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1748
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 2127 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2183
Query: 1749 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1808
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 2184 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2239
Query: 1809 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1859
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 2240 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2297
Query: 1860 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1917
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 2298 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2356
Query: 1918 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1974
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 2357 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2414
Query: 1975 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2031
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 2415 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2474
Query: 2032 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2091
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2475 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2523
Query: 2092 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2151
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2524 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2566
Query: 2152 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2211
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2567 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2607
Query: 2212 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2260
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2608 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2665
Query: 2261 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2317
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2666 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2718
Query: 2318 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2377
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2719 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2762
Query: 2378 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2429
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2763 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2822
Query: 2430 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2475
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2823 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882
Query: 2476 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2942
Query: 2535 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2943 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3000
Query: 2594 EG 2595
G
Sbjct: 3001 LG 3002
Score = 102 bits (255), Expect = 1e-20
Identities = 351/2051 (17%), Positives = 783/2051 (38%), Gaps = 301/2051 (14%)
Query: 3824 LHVPEEPKM--ELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKI 3881
L PE+ L E + L +Y++ + VLS + S + +A E+ DV +
Sbjct: 318 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSW---LLSAEDTLQAQGEISNDVEV---- 370
Query: 3882 DQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 3941
+D + M ++ + R+ N+ G LIG KL ++ +Q
Sbjct: 371 ------VKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQE 418
Query: 3942 TKDSYSA---ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR 3998
+ ++ A QS H + + Q L++ WL+ + + PL
Sbjct: 419 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK-LKELNDWLTKTEERTRKMEEEPLGP 477
Query: 3999 --AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQN 4056
+ +QV+ + LQE DL +++ + D + Q +
Sbjct: 478 DLEDLKRQVQQHKVLQE------DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 531
Query: 4057 LTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ- 4115
L W I + W+ LQD + Q + E + +S+ +D V K+ +
Sbjct: 532 LGDRWANICRWTEDRWVLLQDILLKWQRLTE-----EQCLFSAWLSEKEDAVNKIHTTGF 586
Query: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
N ++ + KL + E K +QS ++DL T
Sbjct: 587 KDQNEMLSSLQKLAVLKADLEKK-------------KQSMGKLYSLKQDLLSTLKNKSVT 633
Query: 4176 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKY--AIEDLKDQKQKMIE 4233
E +L+ F WDNL + +STA +A+ +L + + + ++Q +++
Sbjct: 634 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK 693
Query: 4234 HLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
H +EL ++R ++ I++++ V +T EL W
Sbjct: 694 HAQ---EELPPPPPQ--KKRQITVDSEIRKRLDVDIT-------------ELHSWITR-- 733
Query: 4294 PNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQ 4353
+EA+ QSP + + S+L+ K ++ + R + D + + +++
Sbjct: 734 ---SEAVLQSP-----EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVE 785
Query: 4354 KALSDAQSHVNCLSDLVGQRRKYLN-------KALSEKTQFLMA---VFQATSQIQQHER 4403
+ +++ + +D + Q + LN + LSE+ +L + +Q+QQ E+
Sbjct: 786 QMVNEGVN-----ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 840
Query: 4404 KIMFREHICLL-------PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-- 4454
E+ + P + Q+K CK L Q ++ L Q L ++
Sbjct: 841 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 900
Query: 4455 --------------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500
+Q S+V + +ELQ+++D++ ++E
Sbjct: 901 MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL----------------PPMRYQETM 944
Query: 4501 DKACHWLKQADI-VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTIL 4559
W++Q++ ++ P++++ + + +L + Q + E ++ L L T + +
Sbjct: 945 SAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1003
Query: 4560 PSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSE 4618
+E+ Y SE + ++ + + + K++E + ++ + I+ + ++E
Sbjct: 1004 KKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1062
Query: 4619 LEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQP-- 4675
++ FL+ + P L E L Q CR ++ ++ + +++ +N+ + ++ +P
Sbjct: 1063 VDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEF 1119
Query: 4676 ------------WQPDKMLHLVTLYHR---LKRQTEQRVSLLEDTTSAYQEHEKMCQQLE 4720
Q D M V Y R LK E+ VSL +D + + HE M Q E
Sbjct: 1120 ASRLETELKELNTQWDHMCQQV--YARKEALKGGLEKTVSLQKDLS---EMHEWMTQAEE 1174
Query: 4721 RQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAY 4780
L+ ++ + K +E A E++K A Q +K +T + + P+A
Sbjct: 1175 EYLE--RDFEYKTPDELQKAVEEMKRAKEEA---QQKEAKVKLLTESVNSVIAQAPPVAQ 1229
Query: 4781 EKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPV 4840
E + ++++ + L + + E + + + ++ WL V+ +L
Sbjct: 1230 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1289
Query: 4841 YLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLA 4897
+ ++I E + + H E+ + +RI L +L
Sbjct: 1290 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRI----------------------LAQTLT 1327
Query: 4898 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDV--E 4955
+ +D I E L T + E++ + R ++ + + ++ ++ L L L +
Sbjct: 1328 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1387
Query: 4956 SAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMS 5015
+ ++ + +L S +L+ + K ++ Q+V S +Q+
Sbjct: 1388 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1447
Query: 5016 RDSGAQVDLLQRCTAQWHDYQKAR---EEVIELMNDTEKKLSEFSLLKTSSSH--EAEEK 5070
+D + L Q+ Q+++ +EV + E K E ++++ +H +
Sbjct: 1448 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1507
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
LSE K+ V +V +IV ++ + E L +T + + L A +
Sbjct: 1508 LSEVKSEVEMVIKTGRQIVQKKQTENPKE----------LDERVTALKLHYNELGAKVTE 1557
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+++ LE + ++ TE + +L SA + + L + + + E+
Sbjct: 1558 RKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEI 1617
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE-ITAMQDRCLNMQEKVKTNGKLVKQ 5249
E+Q+ L ++++ + + G++ L+++ ++ + + + + + L+ +
Sbjct: 1618 EKQKVHL-----KSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLE 1672
Query: 5250 ELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEE-LQILLTEATNHRQNIEKMAE 5308
K E + ++ + W+ + L + Q E+ L+ L E + R ++ +
Sbjct: 1673 YQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD 1732
Query: 5309 EQKEKYLG-------LYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSR 5361
+ L SEL+ + A ++ +K + +KE+EQ +
Sbjct: 1733 QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT-GKASIPLKELEQFNS------- 1784
Query: 5362 QIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KVLGEELDGCNSKLMELDAAVQKFLEQN 5419
D+ +L L+A+ V K + K + E+ +G +L++ +Q+ +
Sbjct: 1785 -------DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1837
Query: 5420 GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHL-EEYNEMLELILKWIEKA-KV 5477
+ + K+ +L + ++ ++ K SH +Y + +LK ++ K
Sbjct: 1838 RKREEIKIKQ--QLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKK 1895
Query: 5478 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLT----------SVYC 5527
LA S + R++ + KEID EL+ E+L + +
Sbjct: 1896 LA-------SLPEPRDE--------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA 1940
Query: 5528 TEKMSQQVAELGRETEE---------LRQMIKIRLQNLQDAAKDM--------KKFEAEL 5570
E Q+++ RE E Q+ +R + + +DM + E+
Sbjct: 1941 VEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI 2000
Query: 5571 KKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKP---KVQAVQLCQSALRI 5627
+ AL + + L +P++ ++ + L + +SL+ ++ + ++A
Sbjct: 2001 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ 2060
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
V + L A +L + ++ + +V ++ ++ ++K Q + A
Sbjct: 2061 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2120
Query: 5688 REIEDKPVATS--------NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAK 5739
+ + + + ++ELQ I + + + + + E+I +SK ++ K
Sbjct: 2121 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 2180
Query: 5740 HATMLLTVTEV 5750
++ L EV
Sbjct: 2181 LGSLNLRWQEV 2191
Score = 49.3 bits (116), Expect = 2e-04
Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)
Query: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 200
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 2248 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2304
Query: 201 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 255
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 2305 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2364
Query: 256 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 306
E+ V +PD + I++ K P + + S++ + + +L
Sbjct: 2365 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2415
Query: 307 ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 328
PG + S Q ++ I K
Sbjct: 2416 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2475
Query: 329 -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 383
E+ W+ ++ + +++ +L+D + K E +R Q+E LI
Sbjct: 2476 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2535
Query: 384 KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 431
K S +A ++ WD V L + QL++ L WL E A
Sbjct: 2536 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2591
Query: 432 ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 488
R ++ + T + IQ+K+ + K L ++ R + + + + D
Sbjct: 2592 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2647
Query: 489 LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 540
D + H ++ S +H E LE +RLL L K +W+ +
Sbjct: 2648 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2707
Query: 541 ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 586
+V Q +E+SK E + Y L + ++ +++ ++
Sbjct: 2708 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2767
Query: 587 AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 646
A + + ++ +W L + ++RS LE W R ++ L WL+ + L++
Sbjct: 2768 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2827
Query: 647 ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 702
DF +Q+ ++ A ++T + ++ L+ + L + +L+
Sbjct: 2828 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2882
Query: 703 EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 755
E ++ +A + R+ ++ + V T L+ + + +K+ E LE +Q+
Sbjct: 2883 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2934
Query: 756 LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 815
L++ + + Q ++I K S Q G + ++ E++ ++ +PL
Sbjct: 2935 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2984
Query: 816 ESQQLLIPLEELEKQMTSFYDSLGKIN 842
++ + + +L +Q+T+ L N
Sbjct: 2985 --KENVSHVNDLARQLTTLGIQLSPYN 3009
Score = 35.4 bits (80), Expect = 2.5
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 5868 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5927
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2906 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2965
Query: 5928 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 5983
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2966 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3020
Query: 5984 STIRMKASGKRQLLEEKLND 6003
+++ + + L E D
Sbjct: 3021 KLLQVAVEDRVRQLHEAHRD 3040
>gi|5032283 dystrophin Dp427m isoform [Homo sapiens]
Length = 3685
Score = 306 bits (783), Expect = 8e-82
Identities = 627/3220 (19%), Positives = 1226/3220 (38%), Gaps = 528/3220 (16%)
Query: 24 EQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRM 83
E+E VQK+TFTKW+N+ +K + ++LF D++DG +LL LLE L+GQKLP E+G
Sbjct: 12 EREDVQKKTFTKWVNAQFSKFGKQHI-ENLFSDLQDGRRLLDLLEGLTGQKLPKEKGST- 69
Query: 84 KRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQIE 143
R+HA+ N+ AL+ L+ + LVNI STDI DG + LGL+W IIL++Q++
Sbjct: 70 -RVHALNNVNKALRVLQNNN-------VDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVK 121
Query: 144 ELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQT 203
+ N+ + Q N++K LL WV+ +
Sbjct: 122 NVMKNI-----------------------------MAGLQQTNSEKILLSWVRQSTRNYP 152
Query: 204 GIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVK-GRSNRENLEDAFTIAETELGIPRL 262
+ V +F SW G+A +++IH+ RP+L D +V +S + LE AF IA +LGI +L
Sbjct: 153 QVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKL 212
Query: 263 LDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKRE 322
LDPEDVD PD+KSI+ Y+ + P S + ++ E+LP P +E
Sbjct: 213 LDPEDVDTTYPDKKSILMYITSLFQVLP--QQVSIEAIQEVEMLPRPPKVT-------KE 263
Query: 323 DRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRD 382
+ + +Q L + S+ + +++S+ + + Y H
Sbjct: 264 EHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHL- 322
Query: 383 GKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVH 442
+A +S+ S L + + LD+ A L + +WL AE L+ + +
Sbjct: 323 ------EAPEDKSFG---SSLMESEVNLDRYQTA-LEEVLSWLLSAEDTLQAQGEI---- 368
Query: 443 EETANTIQRKLEQHKDLLQNTDAHKRAFHEIYR--TRSVNGIPVPPDQLEDMAERFHFVS 500
++ + H+ + + AH+ I + ++ + + D+ ++ E+ + ++
Sbjct: 369 SNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLN 428
Query: 501 STSE-LHLMKMEFLELKYRLLSLLVLAESK-LKSWIIKYGRR-------------ESVEQ 545
S E L + ME +R+L L + K L W+ K R E +++
Sbjct: 429 SRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKR 488
Query: 546 LLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEA--ENVMKFMNETTAQWRN 603
+Q + E+ EQ +V L + ++ G A E +K + + +W N
Sbjct: 489 QVQQHKVLQED---LEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGD---RWAN 542
Query: 604 LSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQ 663
+ +L++++ W R AWL + E +N+
Sbjct: 543 ICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKI----------------- 585
Query: 664 HTAMNDAGNFLIETCDEM--VSRDL---KQQLLLLNGRWRELFMEVKQYAQADEMDRMKK 718
HT N ++ + ++ + DL KQ + L ++L +K + + +
Sbjct: 586 HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLD 645
Query: 719 EYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAH 778
+ C L + LE S + + + + VM+ + T+
Sbjct: 646 NFARC-----------WDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQI 694
Query: 779 LITKES-----PQEEGKEMFATMSKLKEQL-TKVKECYSPLLYESQQLLIPLEELEKQMT 832
L+ P + K S+++++L + E +S + L P + ++
Sbjct: 695 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 754
Query: 833 SFYDSLGKINEI--------ITVLEREAQSSALFKQKHQELL-------ACQENCKKTLT 877
+F D K+N I + + + AL +Q E + A ++ + +
Sbjct: 755 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIE 814
Query: 878 LIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK 937
+ S+ + +N++ ++Q + Q+ + + T +++ ++ K
Sbjct: 815 FCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICK 874
Query: 938 ----KFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRV---LNAFLKACD 990
+ + ++E+ L+I L+EKG L F+ ++V + A K
Sbjct: 875 DEVNRLSGLQPQIER-LKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQ 933
Query: 991 ELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKI-DVEKNRFLASVEECRTEL 1049
+ D LP Q A+R W Q E + L + D E +E+ EL
Sbjct: 934 TIFDTLPPMRYQETMSAIR----TWVQ-QSETKLSIPQLSVTDYE------IMEQRLGEL 982
Query: 1050 DR-ETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTC 1108
++ L Q+ + S K P + K EE+
Sbjct: 983 QALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEI----------------- 1025
Query: 1109 HVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHG 1168
K+L + + +KL E +K + + W++ + LK E
Sbjct: 1026 EGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLK----EEWPALGDS 1081
Query: 1169 EV-KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTL 1227
E+ K+ +++ R V+ + ++ L + E + + + + + ++L + K L T
Sbjct: 1082 EILKKQLKQCRLLVS----DIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQ 1137
Query: 1228 LSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLF----------- 1276
+ + + KE +K LE+ +S K++ E E + E +
Sbjct: 1138 WDHMCQQV------YARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPD 1191
Query: 1277 -------EAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLD 1329
E ++ QQK ++ V IAQA P E L+K TL
Sbjct: 1192 ELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA-------PPVAQEALKKELETL- 1243
Query: 1330 GLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQT 1389
T +W N + + L + + LS+ LE + L +
Sbjct: 1244 --------------TTNYQWLCTRLNGK--CKTLEEVWACWHELLSY--LEKANKWLNEV 1285
Query: 1390 KEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTME 1449
+ K TE+I AE E SE+ +N L + ++ Q++ L TL + E
Sbjct: 1286 EFKLKTTENIPGGAE----EISEVLDSLEN---LMRHSEDNPNQIRILAQTLTDGGVMDE 1338
Query: 1450 MVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVG 1509
++ + + F S + L ++K L S+ + + I+ ++ I+ +L++ +
Sbjct: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIA 1398
Query: 1510 LEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGT--ILGHLSQQQKFEEN 1567
+ +A Q E+ +I++ LT EE+++H Q E +L + QK ++
Sbjct: 1399 DKVDAAQMPQ-----EAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQD 1453
Query: 1568 LR---KIQQSVSEFEDKLAV------PIKICSSATETYKVLQE--------HMDLCQALE 1610
+ ++ Q + FE +L +K+ A ET V QE ++L ++L
Sbjct: 1454 VSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLS 1513
Query: 1611 SLSSAITAFSASARKVV------NRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHW 1664
+ S + + R++V N + AL+ Y ++ + ER+ LE L
Sbjct: 1514 EVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLS 1573
Query: 1665 QRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLL 1724
+++ KE++ WL + + + + ++ E+ +A Q E+ Q +
Sbjct: 1574 RKMRKEMNVLTEWLAATDMELTK-RSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSIT 1632
Query: 1725 QLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSF 1784
++ E+L +V K + +++ L L+ W + + +N L + FD+ +
Sbjct: 1633 EVGEALKTVLGKKET-LVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHI 1691
Query: 1785 SVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAE 1844
+ WI + L + + + L R K AE+ + ++ S + A
Sbjct: 1692 TKWIIQADTLLDESEKKKPQQKEDVLKRLK---AELNDIRPKVDSTRDQAA--------- 1739
Query: 1845 DLHLLQGKAEDCFQLFEEASQVVERRQLALSH----------LAEFLQSHASLSGILRQL 1894
+L+ + + C +L E + R A+SH L E Q ++ + +L L
Sbjct: 1740 --NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPL 1797
Query: 1895 RQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTS 1954
E +N E D KD+N+ N ++ D + +I +R
Sbjct: 1798 E--AEIQQGVNLKEED-FNKDMNE--DNEGTVKELLQRGDNL------QQRITDERKREE 1846
Query: 1955 CRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLK 2014
+ L + +++L ++ +A ++ ++ Q ++LLK ++DIE++ L
Sbjct: 1847 IKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL--ASLP 1904
Query: 2015 EPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPE-----VDREINR 2069
EP + R +++ EL + EL ++ +A+ +++ A A E + +
Sbjct: 1905 EPRDE------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE 1958
Query: 2070 LEVTWDDTKRL----IHENQGQCCGLI--DLMREYQNLKSAVSKVLENASSVIVTRTTI- 2122
+E + +RL IH + + ++ D+ E + S + + S ++ +
Sbjct: 1959 IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLL 2018
Query: 2123 -------KDQEDLKWAFSKHETAKNKMNYKQKD---LDNFTSKGKHLLSELKKIHSSDFS 2172
KD EDL F + E+ KN + Q+ +D SK L +
Sbjct: 2019 NAPDLCAKDFEDL---FKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQ 2075
Query: 2173 LVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAE-NI 2231
+ ++ +W V++ ++ R S+ W W + + I
Sbjct: 2076 EALSQLDF---QWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI 2132
Query: 2232 SNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL------ETPPDLQFIE 2285
H + + LKE + + + + L++ ++ + + E L
Sbjct: 2133 PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRW 2192
Query: 2286 ADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEE----SLMNCAQNE 2341
++ ++L K+ E K L +F ++ +N+ W + + L + +
Sbjct: 2193 QEVCKQLSDRKKRLEEQKNILSEF-------QRDLNEFVLWLEEADNIASIPLEPGKEQQ 2245
Query: 2342 TCEALKKVKDIQKELQSQQSNISSTQEN-----LNSLCRKYHSAELES-LGRAMTGLIKK 2395
E L++VK + +EL +Q + E +++ +LE+ L + IK
Sbjct: 2246 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKV 2305
Query: 2396 HEAVSQLCSKTQASLQE--SLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL 2453
A+ + + +A +++ LEK + ++ L + + +
Sbjct: 2306 SRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN---QEGP 2362
Query: 2454 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKD 2513
D+Q +V Q ++ + +GQ LY K ++ ++ + E++A + + L++
Sbjct: 2363 FDVQETEIAVQAKQPDVEEILSKGQHLYK--EKPATQPVKRKLEDLSSEWKA-VNRLLQE 2419
Query: 2514 KQALQ-DCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLG 2572
+A Q D A L + T+ + Q + K+ + K+EM
Sbjct: 2420 LRAKQPDLAPGLTTIGAS---------------PTQTVTLVTQPVVTKETAISKLEMPSS 2464
Query: 2573 ELL----------AARESLDKLSQRGQLLSEEGHGAG--------------------QEG 2602
+L A E D LS Q++ + G Q
Sbjct: 2465 LMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRR 2524
Query: 2603 RLCSQLLTSHQNLLRMTK------------EKLRSCQVALQEH-----EALEEALQSMWF 2645
+L+T+ QNL T E++++ +QEH + L E L+
Sbjct: 2525 PQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQ 2584
Query: 2646 WVKAIQDRLACAESTLG--------------SKDTLEKRLSQIQDILLMKGEGEVKLNMA 2691
W++A ++ AE LG + D ++K++++ + + + + +++A
Sbjct: 2585 WLEAKEE----AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVA 2640
Query: 2692 IGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQ 2751
+ LR + + R + E + W I ++ LE + +
Sbjct: 2641 NDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEK 2700
Query: 2752 LEQWMESVD---------QKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
W+ + + E L+ G+KE L+ Q + E E HT H L
Sbjct: 2701 FLAWLTEAETTANVLQDATRKERLLEDSKGVKE---LMKQWQDLQGEIEAHTDVYHNLDE 2757
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHL---------MYL 2853
S+++ E Q L D M ++RK ++ HL ++L
Sbjct: 2758 NSQKILRSLEGSDDAVLLQRRL-----DNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2812
Query: 2854 DAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS---------KIKELIDSREIGASRL 2904
++ E WL +EL R + + GD A QK+ K KE + + R+
Sbjct: 2813 -SLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRI 2871
Query: 2905 SRVE--------------SLAPEVK-QNTT---ASGCELMHTEMQALRADWKQWEDSVFQ 2946
E L PE + QN T E ++TE + L W+ + +
Sbjct: 2872 FLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDE 2931
Query: 2947 TQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTW 2986
T LE L QE +L+ L Q + +W
Sbjct: 2932 T---LERL--------QELQEATDELDLKLRQAEVIKGSW 2960
Score = 214 bits (544), Expect = 4e-54
Identities = 373/2038 (18%), Positives = 822/2038 (40%), Gaps = 211/2038 (10%)
Query: 6661 YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLE 6720
++ L+ + Q + Q++++G ++ ++ QL W+ +S+ L+
Sbjct: 774 FRKLQDASRSAQALVEQMVNEG------VNADSIKQASEQLNSRWIEFCQLLSERLN--- 824
Query: 6721 TILKHWTRYQSESADLIHWLQSAKDRL---EFWTQQSVTVPQELEMVRDHLNAFLEFSKE 6777
W YQ+ + LQ + E W + T P E ++ L + E
Sbjct: 825 -----WLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKD---E 876
Query: 6778 VDAQSSLKSSVLSTGNQLLRLKKVDTAT--LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6835
V+ S L+ + Q + LK+ L ++ + + + +++ A +++L +
Sbjct: 877 VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTI- 935
Query: 6836 MDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCK 6892
D LP + +S + +W+ E + + ++ + Y+ + + L + + + + +
Sbjct: 936 FDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTD---YEIMEQRLGELQALQSSLQEQ 992
Query: 6893 QLTVDFVNQSVLQISSQ-DVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLE 6951
Q + +++ +V ++S + E R +++F E G W+ L + E Q LE +
Sbjct: 993 QSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGR----WKKLSSQLVEHCQKLEEQMN 1048
Query: 6952 SWSEYENNVQCLKTWFETQEKRLKQQH-RIGDQASVQNALKDCQDLEDLIKAKEKEVEKI 7010
+ +N++Q LK W + LK++ +GD ++ LK C+ L I+ + + +
Sbjct: 1049 KLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSV 1108
Query: 7011 EQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK 7070
+ G + + + +S + + L+EL W ++ V K LK L++ S + +
Sbjct: 1109 NEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSE 1168
Query: 7071 INSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
++ ++ +A + + +Q V+ ++ +++ +++E ++ N ++ +
Sbjct: 1169 MHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1228
Query: 7131 HPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7190
P E L L+ + + L + + ++ + + W Y ++ + + E +
Sbjct: 1229 PPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFK 1288
Query: 7191 TNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7250
LK N +E++ + +L++ +D+ + L + L D
Sbjct: 1289 ----LKTTENIPGGAEEISEVLDSLENLMRHS---EDNPNQIRILAQTL---TDGGVMDE 1338
Query: 7251 IQSDQL-SLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ +++L + + L + ++Q L+ + + KSL ++ + ++ L
Sbjct: 1339 LINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYI- 1397
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN---ELGYR-LPLNDKEIKRMQNLNRH 7365
+ D + + + ++++ + ++ + N E R L D K++Q+++
Sbjct: 1398 ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMK 1457
Query: 7366 WSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRA 7425
+ L ++ + + L + + L++ + + A+E Q +++ Q
Sbjct: 1458 FRLF-----QKPANFEQRLQESKMILDEVKMHLP---------ALETKSVEQEVVQSQLN 1503
Query: 7426 H--ELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR 7483
H L+++ + ++ +I G++++++ Q ++ E + ++T L + + + +R
Sbjct: 1504 HCVNLYKSLSEVKSEV-EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTER 1562
Query: 7484 RGIIDSQIRQWQRYREMAEKLRKWLV--EVSYLPMSGLGSVPIPLQQARTLFDEVQFKEK 7541
+ ++ ++ ++ R+ L +WL ++ S + +P L + + + KE
Sbjct: 1563 KQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLD-SEVAWGKATQKE- 1620
Query: 7542 VFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLL 7601
+ +Q ++ ++ + L + E ++ +L+ + W + + R EE L
Sbjct: 1621 --IEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQ 1678
Query: 7602 KDWEKCEKGI---------ADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGS 7652
K E ++ + AD+L L +KK Q D + L AE ++ V S
Sbjct: 1679 KHMETFDQNVDHITKWIIQADTL--LDESEKKKPQQKEDVLKRLKAE---LNDIRPKVDS 1733
Query: 7653 WTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWA 7712
D L + + IS LN R + + H++ + I L E
Sbjct: 1734 TRDQAANLMANRGDHCRKLVEPQISELNHR-------FAAISHRIKTGKASIP--LKELE 1784
Query: 7713 VFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERL 7772
F N ++ + L +E+++ Q ++ E+ + + +D + + +L Q G+ L
Sbjct: 1785 QF---NSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVK-------ELLQRGDNL 1834
Query: 7773 A-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLA 7831
+ + E K EI+ K + + L DL + R KK E Q + L L
Sbjct: 1835 QQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLD 1894
Query: 7832 HIESELAK-PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACA 7890
IE +LA P D +EI R+L +++E + + + G++ D A
Sbjct: 1895 DIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSE------------DGAA 1942
Query: 7891 TDAECDSIQQATRNLDRRWRNI-CAMSMERRLKI-------EETWRLWQK---------- 7932
E IQ L +RWR I + RRL EET + +
Sbjct: 1943 MAVEPTQIQ-----LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVP 1997
Query: 7933 --FLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQ----LE 7986
+L + + L E+ P + E+L K E + + + L Q ++
Sbjct: 1998 STYLTEITHVSQALLEVEQLLNAPDLCAKDF----EDLFKQEESLKNIKDSLQQSSGRID 2053
Query: 7987 LINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETAR 8046
+I+ + + L++ + + + +W+ + K R + + F
Sbjct: 2054 IIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI 2113
Query: 8047 DSILVWLTEMDLQLTNIEHFSECDVQAKIK-QLKAFQQEISLNHNKIEQIIAQGEQLIEK 8105
WLTE + Q E AK K LK Q I + + A GE++I++
Sbjct: 2114 KIFNQWLTEAE-QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQ 2172
Query: 8106 SEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP--LPDDEHDLSDRELELEDSAA 8163
S DA+I++E+L L QEV ++ K+L L + + DL++ L LE++
Sbjct: 2173 SSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADN 2232
Query: 8164 LSDLHWHDRSADSLLSPQPSSNL---SLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDL 8220
++ + L L L L Q + + + P V S P+ + L
Sbjct: 2233 IASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLV-SAPISPEEQDKL 2291
Query: 8221 SRDLESA------MSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIK 8274
L+ +SRALP +++G+ + G + E ++ E +
Sbjct: 2292 ENKLKQTNLQWIKVSRALP--EKQGEIEAQIKDLGQL-----------EKKLEDLEEQLN 2338
Query: 8275 NTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPEL----------DTSYKG 8324
+ S + +Q+ + + F +Q+TE +++K P E+ + +
Sbjct: 2339 HLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQP 2398
Query: 8325 YMKLLGECSSSIDSVKRLEHKLKEEEESL-PGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
+ L + SS +V RL +L+ ++ L PG + ++ TQT ++ + + + A+SK
Sbjct: 2399 VKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISK 2458
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLE--LSTDIQTIELQIKKLKELQ 8441
L M +L +D N W L D L+Q+ + + + D++ I I K K
Sbjct: 2459 -LEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATM 2517
Query: 8442 KAVDHRKAIILSINLCSPEF-TQADSKESRD-LQDRLSQMNGRWDRVCSLLEEWR----G 8495
+ ++ R+ + + + + ++E+R + DR+ ++ +WD V L+ R
Sbjct: 2518 QDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNE 2577
Query: 8496 LLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELL 8555
+L+D+ + E L ++ K +D+ +Q + Q+ +L
Sbjct: 2578 MLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDA------IQKKITETKQLAKDLR 2631
Query: 8556 ESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLD 8613
+ Q V D++ +LL + D KVH+I + + + + + E E L+
Sbjct: 2632 QWQTNVDVANDLALKLLRDYSADD----TRKVHMITENINASWRSIHKRVSEREAALE 2685
Score = 188 bits (477), Expect = 2e-46
Identities = 535/2989 (17%), Positives = 1112/2989 (37%), Gaps = 447/2989 (14%)
Query: 2516 ALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELL 2575
+L + L ++ ++ W+ E+ + GE + K++ H E ++ +L
Sbjct: 333 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQ--GEISNDVEVVKDQFHTHEGYMMDLT 390
Query: 2576 AARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQE--H 2633
A + + + Q G L G + E + NLL E LR + Q H
Sbjct: 391 AHQGRVGNILQLGSKLIGTGKLSEDE----ETEVQEQMNLLNSRWECLRVASMEKQSNLH 446
Query: 2634 EAL----EEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGE---V 2686
L + L+ + W+ ++R E D LE Q+Q +++ + E V
Sbjct: 447 RVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPD-LEDLKRQVQQHKVLQEDLEQEQV 505
Query: 2687 KLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYV 2746
++N SS ++ QL+ L + WA+I + L+ ++ +W
Sbjct: 506 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
Query: 2747 ERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSIL---SEAEDHTRALHRLIAK 2803
E + W+ + + G K++ +L LQ + ++ E +++ +L +
Sbjct: 566 EEQCLFSAWLSEKEDAVNKI--HTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSL 623
Query: 2804 SRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWL 2863
++L +++S ++ + ++ ++K+E+ + + + +
Sbjct: 624 KQDLLSTLKNKS----VTQKTEAWLDNFARCWDNLVQKLEK----------STAQISQAV 669
Query: 2864 HSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGC 2923
+ + L + + M ++ T ++ +K + + R ++ E+++
Sbjct: 670 TTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDIT 729
Query: 2924 ELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALL 2983
EL H+ + A + E ++F+ + +L ++ E+E + + +L+ A AL+
Sbjct: 730 EL-HSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALV 788
Query: 2984 KTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTY 3043
+ EG N D + +E L S+ E C+ + +
Sbjct: 789 EQMVN-----EGVNADS------------------IKQASEQLNSRWIEFCQLLSERLNW 825
Query: 3044 SGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQN 3103
+ +I YN L Q L+Q A + WL T P
Sbjct: 826 LEYQNNIIAFYNQL------------QQLEQMTTTA----ENWLKIQPTT-------PSE 862
Query: 3104 ISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKG---IQAKVTAAKED 3160
+ + + L+ ++ ++ Q ++ + + ++ KEK +G + A A
Sbjct: 863 PTAIKSQLKICKDEVNRLSGLQPQIERLK-----IQSIALKEKGQGPMFLDADFVAFTNH 917
Query: 3161 WKNFHSNLHQKESALENL--KIQMKDFEVSAEPIQDWL--SKTEKMVHESSNRLYDLPAK 3216
+K S++ +E L+ + + ++ + I+ W+ S+T+ + + S Y++ +
Sbjct: 918 FKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQ 977
Query: 3217 RR-EQQKLQSVLEE----IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLAL 3271
R E Q LQS L+E ++ + + +KA S+ ++ ++ ++ L
Sbjct: 978 RLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPS-----EISRKYQSEFEEIEGRWKKL 1032
Query: 3272 SNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3331
S+ E +L+ + + + I+ L+ WM + L D +L + +
Sbjct: 1033 SSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCR 1092
Query: 3332 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQL 3391
L+S Q + + + G+ + PE ++ +L+ + W + K L
Sbjct: 1093 LLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEAL 1152
Query: 3392 EGALSKWTSYQDGVRQFSGWM-----------------DSMEANLNESERQHAELRDKTT 3434
+G L K S Q + + WM D ++ + E +R E + K
Sbjct: 1153 KGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE- 1211
Query: 3435 MLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKS 3494
K KLL E V S + A + EL+ L Y+ + R
Sbjct: 1212 --AKVKLLTESVNSV--------IAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTL 1261
Query: 3495 EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA 3554
E++ E L+ WL + + KL + G A L L+ L H +
Sbjct: 1262 EEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPN 1321
Query: 3555 LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKF 3614
+ + T D G+ E + ++ + + R E + V + +L+EQ
Sbjct: 1322 QIRILAQTLTD---GGVMD------ELINEELETFNSRWRELHEE---AVRRQKLLEQSI 1369
Query: 3615 QQVDEWLKTAEEKKWH----------EEVTAYRDEVEEVGARAQEI--LDESHVNSRMGC 3662
Q E EK H +++ AY + + QE + + +
Sbjct: 1370 QSAQE-----TEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISL 1424
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
+ + ++ + +VL QI ++++Q + +++ + + +D+
Sbjct: 1425 EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANF----EQRLQESKMILDE 1480
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGH--------SLLKSAREKGERAVKYLEEGEAERLRKE 3774
V + + K++E + + H S +KS E + + + + + KE
Sbjct: 1481 VKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKE 1540
Query: 3775 IHDHMEQLK----ELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEP 3830
+ + + LK EL + V + LEK L L+++ + LT+W+A L
Sbjct: 1541 LDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAV 1600
Query: 3831 KMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELV--QDVTLKDKIDQLQSDY 3888
+ ++++ K+ Q+ + + +KS+ E GEAL ++ ++ ++DK+ L S++
Sbjct: 1601 EGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNW 1660
Query: 3889 QDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA 3948
+ S + + + ++ + Q DH+ + Q
Sbjct: 1661 IAVTSRAEEWLNLLLEYQKHMETFD--------QNVDHITKWIIQ--------------- 1697
Query: 3949 ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR---------- 3998
A + E E +K ++D L++ +A L+ ++P ++ + +
Sbjct: 1698 ----ADTLLD--ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRK 1751
Query: 3999 --AEAIKQVKH-FRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQ 4055
I ++ H F A+ + +T + ++ DIQ+ + +E ++ Q
Sbjct: 1752 LVEPQISELNHRFAAISHRIKT------GKASIPLKELEQFNSDIQKLLEPLEAEIQQGV 1805
Query: 4056 NLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ 4115
NL + E+ +E D + ++ + +R L+ I + +++ KQ
Sbjct: 1806 NLKE--EDFNKDMNE------DNEGTVKELLQRGDNLQQRITDERKRE------EIKIKQ 1851
Query: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL--CLQR-EEDLQRTRDYH 4172
+ T K N L K S K+ ++ QW RQ+++L CL E+ L +
Sbjct: 1852 QLLQT---KHNAL-KDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPR 1907
Query: 4173 DCMNVVEVFLE-KFTTEWDNLARSDAESTAVH--LEALKKLALALQERKYAIEDLKDQKQ 4229
D + E+ E + E N R AE + A++ + L +R IE K
Sbjct: 1908 DERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIE----SKF 1963
Query: 4230 KMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWA 4289
LN V+E+T + LE I +T + ++ ++L+
Sbjct: 1964 AQFRRLNFAQIHTVREETMMVMTEDMPLE--ISYVPSTYLTEITHVSQALLEVEQLLNAP 2021
Query: 4290 EEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNER 4349
+ + + KQ ++ L + +K+ + ++ A V ER
Sbjct: 2022 DLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKK---TAALQSATPV-------ER 2071
Query: 4350 QVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQF---LMAVFQATSQIQQHERKIM 4406
+Q+ALS ++ + R+ ++++ + +F + Q ++ +Q RK
Sbjct: 2072 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2131
Query: 4407 FREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQ 4466
E+ + +K K Q + Q V L A G E++++ ++ + S + KL
Sbjct: 2132 IPENW-----EHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLG 2186
Query: 4467 ELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSE 4526
L + V ++ S R + LE+ F+ D ++ WL++AD + + + +
Sbjct: 2187 SLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQ 2245
Query: 4527 LHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPS--LNEVDHSYLSEKLNALPRQFNVI 4584
L +L + + ++E+ P + +L L TG +L S ++ + L KL +Q N+
Sbjct: 2246 LKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL----KQTNL- 2300
Query: 4585 VALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDG 4644
++ KV A+ + E+EAQ
Sbjct: 2301 ------QWIKVSRAL-------------PEKQGEIEAQ---------------------- 2319
Query: 4645 CRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLED 4704
+ LG+ +L +E ++ HL+ ++ Q E ++
Sbjct: 2320 -------IKDLGQLEKKLEDLEE------------QLNHLLLWLSPIRNQLEIYNQPNQE 2360
Query: 4705 TTSAYQEHEKMCQQLERQLKSVKEEQSKVNEE---TLPAEEKLKMYHSLAGSLQDSGIVL 4761
QE E Q + ++ + + + +E T P + KL+ L+ + +L
Sbjct: 2361 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLE---DLSSEWKAVNRLL 2417
Query: 4762 KRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSI----D 4817
+ + DLAP L + + Q ++T + E S ++ + D
Sbjct: 2418 QELRAKQPDLAPGLTTIGASPTQTVTLVTQ---PVVTKETAISKLEMPSSLMLEVPALAD 2474
Query: 4818 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQ-----IHQEEVQSSLRIMNA 4872
F + DWL + + + +L+DI E I K + + Q Q I A
Sbjct: 2475 FNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAA 2534
Query: 4873 LSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQ 4932
+ K K +A+ +I+ +E + E +QE L+ R+ L E + +
Sbjct: 2535 QNLKNKTSNQEARTIITDRIERIQNQWDE----VQEHLQNRRQQLNE----------MLK 2580
Query: 4933 AANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 4992
+ WLE +E Q+ G A L+S E T D + E L L
Sbjct: 2581 DSTQWLEAKEEAEQVLG------QARAKLESWKEGPYTVDAIQKKITETKQLAKDLR--- 2631
Query: 4993 KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLL-QRCTAQWHDYQKAREEVIELMNDTEK 5051
+ D+ +A LR S D +V ++ + A W K E + +T +
Sbjct: 2632 QWQTNVDVANDLALKLLRD--YSADDTRKVHMITENINASWRSIHKRVSEREAALEETHR 2689
Query: 5052 KLSEFSL------------------LKTSSSHE--------AEEKLSEHKALVSVVNSFH 5085
L +F L L+ ++ E +E + + + L + +
Sbjct: 2690 LLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHT 2749
Query: 5086 EKIVALEEKASQLEKTGNDASKAT-LSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTG 5144
+ L+E + ++ ++ + A L R + + +W+ LR + + LE + D+W
Sbjct: 2750 DVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKR 2809
Query: 5145 FNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQT 5204
+ +++ + D+L + + + H F EL+ ++ + M +T
Sbjct: 2810 LHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI-MSTLET 2868
Query: 5205 LSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
+ + E+P E + R L +E+ + +L++ K E V T+ +
Sbjct: 2869 VRIFLT-------EQPLEGLEKLYQEPRELPPEERAQNVTRLLR---KQAEEVNTEWEKL 2918
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE 5324
+ + +ID LE LQ L EAT+ + AE K + + +L
Sbjct: 2919 NLHSADWQR-------KIDETLERLQ-ELQEATDELDLKLRQAEVIKGSWQPVGDLLIDS 2970
Query: 5325 LSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTI 5373
L L +K+K + A +E + LA+ LTT+
Sbjct: 2971 LQDHL--------------EKVKALRGEIAPLKENVSHVNDLARQLTTL 3005
Score = 187 bits (474), Expect = 5e-46
Identities = 471/2537 (18%), Positives = 960/2537 (37%), Gaps = 458/2537 (18%)
Query: 5859 EPSATAKLGDLQRSWETLKNVISEKQRTLYEAL-ERQQKYQDSLQSISTKMEAIELKLSE 5917
E ++ L WE L+ EKQ L+ L + Q + L TK E K+ E
Sbjct: 417 ETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEE 476
Query: 5918 SP--EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQST 5975
P + Q+ +H+ L +++ Q +N L + +V + D A AL+
Sbjct: 477 EPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV---VVVDESSGDHATA-ALEEQ 532
Query: 5976 LTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQR--QEQALQRYRCEADELDSWLLSTKA 6033
L VL +R + I + LL++ L L+ QR +EQ L +WL +
Sbjct: 533 LKVLGDRWANICRWTEDRWVLLQDIL---LKWQRLTEEQCL---------FSAWLSEKED 580
Query: 6034 TLDTALSPP-KEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLL--LEGKAHTKDE 6090
++ + K+ +M + L + ++E+K ++ +L ++LL L+ K+ T+
Sbjct: 581 AVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKT 640
Query: 6091 AEQLAGKLR-------RLKGSLLELQRALHDKQLNM-QGTAQEKEESDVDLTATQSPGVQ 6142
L R +L+ S ++ +A+ Q ++ Q T E V T+ +
Sbjct: 641 EAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMET----VTTVTTREQILV 696
Query: 6143 EWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEIL-------------- 6188
+ + Q++ + E+ + L + L S +R E +L
Sbjct: 697 KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNF 756
Query: 6189 ---------IQHSAAETSG---DAGEKPDVLSQELGMEGEKSS----AEDQMRMKWESLH 6232
I+ AE DA L +++ EG + A +Q+ +W
Sbjct: 757 SDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC 816
Query: 6233 QEFSTKQKLLQ---NVLE-----QEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV---- 6280
Q S + L+ N++ Q+ EQ+ + N L + PT KS +
Sbjct: 817 QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLK--IQPTTPSEPTAIKSQLKICK 874
Query: 6281 --TSLLDGLNQAFEEVSSQSGGAKRQ--------------SIHLEQKLYD---------- 6314
+ L GL E + QS K + + H +Q D
Sbjct: 875 DEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQT 934
Query: 6315 ------------GVSATSTWLDDVEERLFVATALLP--EETETCLFNQEILAKDIKEMSE 6360
+SA TW+ E +L + + E E L + L ++E
Sbjct: 935 IFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQS 994
Query: 6361 EM--------DKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERL 6412
+ + +K S+ + + IE GR L S + + C +++E++
Sbjct: 995 GLYYLSTTVKEMSKKAPSEISRKYQSEFEEIE-------GRWKKLSSQLVEHCQKLEEQM 1047
Query: 6413 QQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPV-AEQIEAIQQAEDGLKEFDAGIIE 6471
++ QN ++ L +A+ + ++ + + + +Q++ + ++ +
Sbjct: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1107
Query: 6472 LKRRGDKLQVE-QPSM-----QELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQ 6525
+ G K++ E +P EL +L +D + + +R+ L L ++ L
Sbjct: 1108 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1167
Query: 6526 DLADLLETGQEKMAGDQKIIVSSKEEIQQLLD---KHKEYFQGLESHM-ILTETLFRKII 6581
++ + + +E+ ++ + +E+Q+ ++ + KE Q E+ + +LTE++ I
Sbjct: 1168 EMHEWMTQAEEEYL-ERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIA 1226
Query: 6582 SF------AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLE 6635
A++KE + L + R + + LE + W L ++ ++ L
Sbjct: 1227 QAPPVAQEALKKELE---TLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN 1283
Query: 6636 VVESSIPSV----GLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISC 6691
VE + + G EE + L L +H + + N+ + L Q L DG
Sbjct: 1284 EVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIR-ILAQTLTDG--------- 1333
Query: 6692 SDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWT 6751
++ +N+ E + S ++ +E R + +L+ + E+ +H +Q + L F
Sbjct: 1334 GVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQ---ESLTFID 1390
Query: 6752 QQ----------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQL-LRLKK 6800
+Q + +PQE + ++ L + +E+ + K + +Q+ + KK
Sbjct: 1391 KQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKK 1450
Query: 6801 VDTATLRSELSRIDSQWTDLL-----------TNIPAVQEKLHQLQMDKLPSRH------ 6843
+ +++ L + + + L ++PA++ K + ++ + H
Sbjct: 1451 LQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYK 1510
Query: 6844 AISEVMSWISLM----ENVIQKDE-DNIK-------------NSIGYKAIHEYLQKYKGF 6885
++SEV S + ++ ++QK + +N K N +G K Q K
Sbjct: 1511 SLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCL 1570
Query: 6886 KIDINCKQ-----------LTVDFVNQSVLQ--------------ISSQDVESKR----- 6915
K+ ++ ++ +S ++ + +++E ++
Sbjct: 1571 KLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKS 1630
Query: 6916 -------------SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQC 6962
+T ++L +N +W + E + LL + ++ NV
Sbjct: 1631 ITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDH 1690
Query: 6963 LKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKE-------VEKIEQNGL 7015
+ W + L + + K Q ED++K + E V+
Sbjct: 1691 ITKWIIQADTLLDESEK-----------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAA 1739
Query: 7016 ALIQNKKEDVSSIVMSTLRELGQTWANLDHMV--GQLKILLKSVLDQWSSHKVAFDKINS 7073
L+ N+ + +V + EL +A + H + G+ I LK + S + + + +
Sbjct: 1740 NLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEA 1799
Query: 7074 ------YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLL 7127
L E ++ G+++ + + DNLQ D K+E I QLL
Sbjct: 1800 EIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI-----KIKQQLL 1854
Query: 7128 KECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQ 7187
+ H N LK++ + EI+ Q W +YK + +
Sbjct: 1855 QTKH--------NALKDLRSQRRKKALEISHQ----------WYQYKRQADDLLKCLDDI 1896
Query: 7188 EDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASA 7247
E + L + + I ++ + L K+ L + E L + A
Sbjct: 1897 EKKLASLPEPRDERKI------------KEIDRELQKKKEELNAVRRQAEGLSED---GA 1941
Query: 7248 ASAIQSDQLSLSQHLCALEQALCK------------QQTSLQAGVLDY--------ETFA 7287
A A++ Q+ LS+ +E + ++ ++ D T+
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYL 2001
Query: 7288 KSLEALEAWIVEAEEILQGQD--PSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7345
+ + ++E E++L D DL +E ++ +K + + S +
Sbjct: 2002 TEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061
Query: 7346 GYRLPLNDKEIKRMQNLNR---HWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLV 7402
+ + +K + L++ W ++ +R + + + + F + + ++L
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121
Query: 7403 QTEQKL-AVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE 7461
+ EQ L +I N++H + EL Q + RQ ++ ++ G+ +++Q D
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKEL-QDGIGQRQTVVRTLNATGEEIIQQSSKTDASI 2180
Query: 7462 FNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7521
KL L+ +WQ V ++ R+ ++ Q ++ + WL E + S
Sbjct: 2181 LQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEA-----DNIAS 2235
Query: 7522 VPI---PLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEA--ALQAEL 7576
+P+ QQ + ++V+ + +QG E G +L+SA E L+ +L
Sbjct: 2236 IPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKL 2295
Query: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLS---QSLPDHH 7633
+ +W S L E++ ++ +KD + EK + D E+L LS L ++
Sbjct: 2296 KQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYN 2355
Query: 7634 EELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWE-- 7691
+ +E E AV + D+ + +L Y + ++E L +W+
Sbjct: 2356 QPNQEGPFDVQETEIAVQAKQPDVEE--ILSKGQHLYKEKPATQPVKRKLEDLSSEWKAV 2413
Query: 7692 -ELCHQLSLRRQQIGERL--------------------NEWAV----------------- 7713
L +L ++ + L E A+
Sbjct: 2414 NRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA 2473
Query: 7714 -FSEKNKELCEWLTQMESKVSQN----GDIL-IEEMIEKLKKDYQEEIAIAQENKIQLQQ 7767
F+ EL +WL+ ++ + GD+ I EMI K K Q+ ++ + QL++
Sbjct: 2474 DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQD----LEQRRPQLEE 2529
Query: 7768 M---GERLA-KASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKET-------LVAV 7816
+ + L K S++ + I ++ ++ ++W + + + R ++L E L A
Sbjct: 2530 LITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAK 2589
Query: 7817 QQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVL 7876
++ ++ + R A +ES P D+ IQ+K+ E ++L +D+ + T V
Sbjct: 2590 EEAEQVLGQAR---AKLESWKEGPYTVDA-----IQKKITETKQLAKDLRQWQTNVDVAN 2641
Query: 7877 NLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDD 7936
+L LL D A T + T N++ WR+I ER +EET RL Q+F D
Sbjct: 2642 DLALKLLRDYSADDT----RKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLD 2697
Query: 7937 YSRFEDWLKSSERTA-----------AFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQL 7985
+F WL +E TA S GV KE +K+++ Q ++
Sbjct: 2698 LEKFLAWLTEAETTANVLQDATRKERLLEDSKGV-----KELMKQWQDLQGEIEAHTDVY 2752
Query: 7986 ELINKQYRRLARE-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFET 8044
+++ +++ R +D A L++ + N +W L+K+ +I L+ Q +
Sbjct: 2753 HNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHL 2812
Query: 8045 ARDSILVWLTEMDLQLT 8061
+ +LVWL D +L+
Sbjct: 2813 SLQELLVWLQLKDDELS 2829
Score = 186 bits (472), Expect = 9e-46
Identities = 413/2178 (18%), Positives = 857/2178 (39%), Gaps = 306/2178 (14%)
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLE-SHMILTETLFRKIISFAV 6585
+ ++L+ G K+ G K+ + E+Q+ ++ ++ L + M L R ++
Sbjct: 396 VGNILQLGS-KLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQN 454
Query: 6586 QKETQFHTELMAQASAVLKRAHKR-GVELEYILETWSHLDEDQQELSRQLEVVESSIPSV 6644
QK + + L K + G +LE + Q++L ++ V S V
Sbjct: 455 QKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMV 514
Query: 6645 GLVEENED-----RLIDRITLYQHLKSSLNEYQPKLYQVLDD---------GKRLLISIS 6690
+V+E+ L +++ + +++ + + +L D ++ L S
Sbjct: 515 VVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAW 574
Query: 6691 CSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW 6750
S+ E +N++ + N+M L +L +LK + +S ++ L+ +D L
Sbjct: 575 LSEKEDAVNKIHTTGFKDQNEMLSSLQKL-AVLKADLEKKKQSMGKLYSLK--QDLLSTL 631
Query: 6751 TQQSVTVPQEL---EMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLR 6807
+SVT E R N + K S ++ + Q ++ V T T R
Sbjct: 632 KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTR 691
Query: 6808 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA---ISEVMSWISLMENVIQKDED 6864
++ +Q + L P +K Q+ +D + I+E+ SWI+ E V+Q E
Sbjct: 692 EQILVKHAQ--EELP--PPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 747
Query: 6865 NIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDV-ESKRSDKTDFAE 6923
I G + +K + + K + ++S + Q V E +D A
Sbjct: 748 AIFRKEG--NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
Query: 6924 QLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV-------QCLKTWFETQEKRLK- 6975
+ +N W L++E++ +W EY+NN+ Q L+ T E LK
Sbjct: 806 E--QLNSRWIEFCQLLSERL--------NWLEYQNNIIAFYNQLQQLEQMTTTAENWLKI 855
Query: 6976 QQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKED--VSSIVMSTL 7033
Q + ++++ LK C+D + + + ++E+++ +AL + + + + ++
Sbjct: 856 QPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFT 915
Query: 7034 RELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLE 7093
Q ++++ +L+ + ++ ++ I +++ ++ LS +L E
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWVQQSETKLSIPQLSVTDYE 973
Query: 7094 AVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLL 7153
++ ++ LQ LQ L++Q+ L + ++ K+ ++ + +E+ RW L
Sbjct: 974 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1033
Query: 7154 EEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7213
++ E Q + + ++ +++ + + + + E A + +I + ++
Sbjct: 1034 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQ----LK 1089
Query: 7214 DCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS---QHLCALEQALC 7270
C L+ + T++ SL ++E G+++K + + AS ++++ L+ H+C Q +
Sbjct: 1090 QCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMC---QQVY 1146
Query: 7271 KQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQML 7330
++ +L+ G+ + K L + W+ +AEE +D + + +Q+ +EE+K
Sbjct: 1147 ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTP-DELQKAVEEMKRAKE 1205
Query: 7331 KFSSMAPDLDRLNE-----LGYRLPLNDKEIKR-MQNLNRHWSLISSQTTERFSKLQS-F 7383
+ + L E + P+ + +K+ ++ L ++ + ++ + L+ +
Sbjct: 1206 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265
Query: 7384 LLQHQ--TFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILH 7441
H+ ++LEK W+ V+ + K I G + + E + + M + +
Sbjct: 1266 ACWHELLSYLEKANKWLN-EVEFKLKTTENIPGGAEEISE---VLDSLENLMRHSEDNPN 1321
Query: 7442 SIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMA 7501
I I Q L + G +D+ N +L +++W+ + A +R+ +++ I+ Q +
Sbjct: 1322 QIRILAQTLTDGGVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSL 1379
Query: 7502 EKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQ-GSYILTVEAGKQL 7560
+++ L I Q A + D+V + Q+ S + + E +
Sbjct: 1380 HLIQESLTF-------------IDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEE 1426
Query: 7561 LLSADSGAEAALQAELAEI---QEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEK 7617
+ + G EAA Q L++I Q+K + SM+ +K F E+ + +S
Sbjct: 1427 MKKHNQGKEAA-QRVLSQIDVAQKKLQDVSMKFRLFQKPANF--------EQRLQESKMI 1477
Query: 7618 LRTFKKKLS--QSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADD 7675
L K L ++ E + ++ C L ++ ++ + + ++
Sbjct: 1478 LDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTEN 1537
Query: 7676 ISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQN 7735
L+ERV L+ + EL +++ R+QQ+ + L ++ L EWL + ++++
Sbjct: 1538 PKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKR 1597
Query: 7736 GDILIEEMIEKLK------KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLG 7789
+E M L K Q+EI + + + ++GE L K K + +E KL
Sbjct: 1598 S--AVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEAL-KTVLGKKETLVEDKLS 1654
Query: 7790 KVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSE 7849
+N W + + L E ++ D+N+ + W+ ++ L +
Sbjct: 1655 LLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLL-----------D 1703
Query: 7850 EIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRW 7909
E ++K +Q+E VL + L+D + DS + NL
Sbjct: 1704 ESEKKKPQQKE-------------DVLKRLKAELND-----IRPKVDSTRDQAANLMANR 1745
Query: 7910 RNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYT-VAKEEL 7968
+ C +E ++ SE F + S I T A L
Sbjct: 1746 GDHCRKLVEPQI-------------------------SELNHRFAAISHRIKTGKASIPL 1780
Query: 7969 KKFEAFQRQVHECLTQLEL-----INKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQK 8023
K+ E F + + L LE +N + ++ D+ ++K+++ QR DNLQ+
Sbjct: 1781 KELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELL----QRGDNLQQ 1836
Query: 8024 RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ 8083
R+T + K +++K QQ
Sbjct: 1837 RITD--------------------------------------------ERKREEIKIKQQ 1852
Query: 8084 EISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLP 8143
+ HN ++ + +Q + A I + + +R ++ ++ KKL LP
Sbjct: 1853 LLQTKHNALKDLRSQRRK--------KALEISHQWYQYKRQADDLLKCLDDIEKKLASLP 1904
Query: 8144 LPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDT 8203
P DE + + + EL+ +L+ R A+ L + + +++ Q S+R
Sbjct: 1905 EPRDERKIKEIDRELQKKK--EELNAVRRQAEGL--SEDGAAMAVEPTQIQLSKRWREIE 1960
Query: 8204 PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVMIPESPE 8263
L + + + + M+ +P E YL +S ++
Sbjct: 1961 SKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPST---YLTEITHVSQALLE---- 2013
Query: 8264 AYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYK 8323
V+ NA + D L Q L K + DS Q +II SK
Sbjct: 2014 --VEQLLNAPDLCAKDFEDLFKQEESL-KNIKDSLQQSSGRIDIIHSKK----------- 2059
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSK 8383
++++ S +E +E S F +WE + +
Sbjct: 2060 ---------TAALQSATPVERVKLQEALSQLDF---------------QWEKVNKMYKDR 2095
Query: 8384 ELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIK-KLKELQK 8442
+ R ++++KW++F+ D+ WL + E+ L + Q E + K LKELQ
Sbjct: 2096 QGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPE-----NWEHAKYKWYLKELQD 2150
Query: 8443 AVDHRKAIILSINLCSPEFTQADSK-ESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDAL 8501
+ R+ ++ ++N E Q SK ++ LQ++L +N RW VC L + + L++
Sbjct: 2151 GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQK 2210
Query: 8502 MQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRV 8561
F + +L LE D + +P++ + + L++ +Q+ + EL Q +
Sbjct: 2211 NILSEFQRDLNEFVLWLEEADNIAS--IPLEPGKEQQ-LKEKLEQVKLLVEELPLRQGIL 2267
Query: 8562 ASLQDMSCQLLVNA----EGTDCLEAKEKVH-----VIGNRLKLLLKEVSRHIKEL---- 8608
L + +LV+A E D LE K K + L E+ IK+L
Sbjct: 2268 KQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLE 2327
Query: 8609 EKLLDVSSSQQDLSSWSS 8626
+KL D+ L W S
Sbjct: 2328 KKLEDLEEQLNHLLLWLS 2345
Score = 179 bits (455), Expect = 8e-44
Identities = 534/2881 (18%), Positives = 1106/2881 (38%), Gaps = 406/2881 (14%)
Query: 5886 TLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPE---SQMAEHQALMDEILML 5942
+L E+ +YQ +L+ + + + + E L E E Q H+ M ++
Sbjct: 333 SLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH 392
Query: 5943 QDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLN 6002
Q + + L +L+ + E+ +Q + +L R +R+ + K+ L L
Sbjct: 393 QGRVGNILQ-LGSKLIGTG-KLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM 450
Query: 6003 DQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEP--MDMEAQLMDCQNMLV 6060
D Q Q L+ EL+ WL T+ P P D++ Q+ + +
Sbjct: 451 DL-----QNQKLK-------ELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQE 498
Query: 6061 EIEQKVVALSELS----VHNENLLLEGKAHTKDEAEQLAGKLRR-----------LKGSL 6105
++EQ+ V ++ L+ V +E+ A +++ + L + L+ L
Sbjct: 499 DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDIL 558
Query: 6106 LELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKE 6165
L+ QR L ++Q EKE++ + T E L SSLQ+
Sbjct: 559 LKWQR-LTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEML------------SSLQKLAV 605
Query: 6166 LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAE-DQM 6224
L+ +L ++K + + S +++L + +K+ A D
Sbjct: 606 LKADLEKKKQSMGKLYSLKQDLLSTLKNKSVT------------------QKTEAWLDNF 647
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLL 6284
W++L Q+ L+ Q + V ++P+ + V V T+++ V
Sbjct: 648 ARCWDNLVQK-------LEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILV---- 696
Query: 6285 DGLNQAFEEVSSQSGGAKRQ---SIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
A EE+ KRQ + ++L ++ +W+ E L +
Sbjct: 697 ---KHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVL--------QSP 745
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNK----------NLFSQAFPENGDNRDVIEDTLGCLL 6391
E +F +E D+KE +++ K + +QA E N V D++
Sbjct: 746 EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQAS 805
Query: 6392 GRLSLLDSVVNQRCHQMKERLQ------QILNFQNDLKVL--FTSLADNKYIILQKLANV 6443
+L+ S + C + ERL I+ F N L+ L T+ A+N ++ +Q
Sbjct: 806 EQLN---SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAEN-WLKIQPTTPS 861
Query: 6444 FEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSK----LQDMYDEL 6499
+ Q++ + + L I LK + L+ + L + + ++
Sbjct: 862 EPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQV 921
Query: 6500 MMIIGSRRSGLNQ--NLTLKSQYERALQDLADLLETGQEKMA------GDQKIIVSSKEE 6551
+ +R L + +Y+ + + ++ + K++ D +I+ E
Sbjct: 922 FSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGE 981
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ----ASAVLKRAH 6607
+Q L +E GL + + +K S +K E+ + +S +++
Sbjct: 982 LQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQ 1041
Query: 6608 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSS 6667
K ++ + + +H+ ++ ++ ++ P++G + + L ++ + L S
Sbjct: 1042 KLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALG----DSEILKKQLKQCRLLVSD 1097
Query: 6668 LNEYQPKLYQVLDDGKRLLISIS---CSDLESQLNQLGECWLSNTNKMSKELHRLETILK 6724
+ QP L V + G+++ S LE++L +L W ++ L+ L+
Sbjct: 1098 IQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLE 1157
Query: 6725 HWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSKEVDAQSS 6783
Q + +++ W+ A++ E+ + P EL+ + + E +++ +A+
Sbjct: 1158 KTVSLQKDLSEMHEWMTQAEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVK 1215
Query: 6784 LKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRH 6843
L + S + + + V L+ EL + + + L T + + L ++
Sbjct: 1216 LLTE--SVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1273
Query: 6844 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6903
+ + W++ +E + K +NI G + I E L + N + + D NQ
Sbjct: 1274 YLEKANKWLNEVEFKL-KTTENIPG--GAEEISEVLDSLE------NLMRHSEDNPNQ-- 1322
Query: 6904 LQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCL 6963
++I +Q + E+L N W+ L + +LLE ++S E E ++ +
Sbjct: 1323 IRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLI 1382
Query: 6964 KTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNG--------- 7014
+ +K+L I D+ ++ Q ++ + + E +E+++++
Sbjct: 1383 QESLTFIDKQLAAY--IADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRV 1440
Query: 7015 ---LALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKI 7071
+ + Q K +DVS L Q AN + + + K++L
Sbjct: 1441 LSQIDVAQKKLQDVSMKF-----RLFQKPANFEQRLQESKMILD---------------- 1479
Query: 7072 NSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECH 7131
E + L + E VQ Q+++ NL L + + ++ Q++++
Sbjct: 1480 -----EVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQ 1534
Query: 7132 PPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRT 7191
+ L + + + +N L ++ E+ Q + L+L ++ + K+ +
Sbjct: 1535 TENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR---KEMNVLTEWLAATD 1591
Query: 7192 NELLKAATNKDIA---DDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAA 7248
EL K + + + D EVA W + K + K L + E+GE LK +
Sbjct: 1592 MELTKRSAVEGMPSNLDSEVA-WGKATQ---KEIEKQKVHLKSITEVGEALKTVLGKK-- 1645
Query: 7249 SAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDY----ETFAKSLEALEAWIVEAEEIL 7304
+ D+LSL + ++ +L +L+Y ETF ++++ + WI++A+ +L
Sbjct: 1646 ETLVEDKLSLLNSNWIAVTSRAEEWLNL---LLEYQKHMETFDQNVDHITKWIIQADTLL 1702
Query: 7305 QGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKR------ 7358
S+ Q++ + LK + + + P +D + L N + R
Sbjct: 1703 D------ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQ 1756
Query: 7359 MQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQ 7417
+ LN ++ IS + T + S L Q + ++K +E +Q L E
Sbjct: 1757 ISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNK-- 1814
Query: 7418 HLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVI 7477
+ +E E+ R L I D ++ R+E +K LL + +
Sbjct: 1815 ---DMNEDNEGTVKELLQRGDNLQQRITDERK---------REEIKIKQQLLQTKHNALK 1862
Query: 7478 RRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQ 7537
QRR QW +Y+ A+ L K L ++ L S+P P DE +
Sbjct: 1863 DLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIE----KKLASLPEPR-------DERK 1911
Query: 7538 FKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL 7597
KE Q+ L + LS D GA A++ ++ ++W+ + Q ++L
Sbjct: 1912 IKEIDRELQKKKEELNAVRRQAEGLSED-GAAMAVEPTQIQLSKRWREIESKFA-QFRRL 1969
Query: 7598 AF----------LLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELE 7647
F ++ E I+ T +SQ+L + + L+A + K+ E
Sbjct: 1970 NFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFE 2029
Query: 7648 N------AVGSWTDDLTQLSLLKDTL-----SAYISADDISI--LNERVELLQRQWEELC 7694
+ ++ + D L Q S D + +A SA + L E + L QWE++
Sbjct: 2030 DLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVN 2089
Query: 7695 HQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLK-----K 7749
R+ + + +W F K +WLT+ E + + I E E K K
Sbjct: 2090 KMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ---IPENWEHAKYKWYLK 2146
Query: 7750 DYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKL 7809
+ Q+ I Q L GE + + S ++ AS ++ KLG +N RWQ + ++ R K+L
Sbjct: 2147 ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRL 2206
Query: 7810 KETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHS 7869
+E + + ++++ WL ++ + P+ + ++++ KL + + L ++
Sbjct: 2207 EEQKNILSEFQRDLNEFVLWLEEADNIASIPL--EPGKEQQLKEKLEQVKLLVEELPLRQ 2264
Query: 7870 TGVASVLNLC--EVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIE--- 7924
G+ LN VL+ A + E D ++ + + +W + E++ +IE
Sbjct: 2265 -GILKQLNETGGPVLV---SAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQI 2320
Query: 7925 -ETWRLWQKFLDDYSRFED---WLK----------SSERTAAFPSSSGVIYTVAKE---- 7966
+ +L +K D + WL + F I AK+
Sbjct: 2321 KDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVE 2380
Query: 7967 -----------ELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGN 8015
E + +R++ + ++ + +N+ + L R + D A L +
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL-RAKQPDLAPGLTTIGASPT 2439
Query: 8016 QRWDNLQKRV----TSILR-----RLKHFIGQREEFETARDSILVWLTEMD--LQLTNIE 8064
Q + + V T+I + L + +F A + WL+ +D ++ +
Sbjct: 2440 QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499
Query: 8065 HFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRR 8123
D+ I + KA Q++ ++E++I + L K+ +A II + ++ ++
Sbjct: 2500 VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQN 2559
Query: 8124 YCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPS 8183
EV ++ ++L + + + E E A + L ++ + Q
Sbjct: 2560 QWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKK 2619
Query: 8184 SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDK 8243
+ LA+ LR +W + D++ DL + R D D +
Sbjct: 2620 ITETKQLAKDLR-----------------QWQTNVDVANDLALKLLR-----DYSADDTR 2657
Query: 8244 DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGK-ALDDSRF--- 8299
+ MI E+ A + K S +ALE R L + LD +F
Sbjct: 2658 KVH----------MITENINASWRSIH---KRVSEREAALEETHRLLQQFPLDLEKFLAW 2704
Query: 8300 --QIQQTENIIRSKTPTGPELDTS------YKGYMKLLGECSSSIDSVKRLEHKLKEEEE 8351
+ + T N+++ T L+ S K + L GE + D L+ ++
Sbjct: 2705 LTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILR 2764
Query: 8352 SLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDT 8411
SL G + + + + +W L+ ++L+ ++ + +W++ + L + WL
Sbjct: 2765 SLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLK 2824
Query: 8412 EEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKE--- 8468
++EL + + + D ++ Q + ++ + ++ +I+S F E
Sbjct: 2825 DDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLE 2882
Query: 8469 ------------------SRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEM 8510
+R L+ + ++N W+++ +W+ + + L + Q E
Sbjct: 2883 KLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEA 2942
Query: 8511 SHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQ 8570
+ L L L + K P+ +L + LQDH +++ ++ E+ + V+ + D++ Q
Sbjct: 2943 TDELDLKLRQAEVIKGSWQPV-GDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQ 3001
Query: 8571 L 8571
L
Sbjct: 3002 L 3002
Score = 179 bits (453), Expect = 1e-43
Identities = 533/2827 (18%), Positives = 1093/2827 (38%), Gaps = 366/2827 (12%)
Query: 5183 HDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR--CLNMQEKV 5240
H+ ++++L Q +G + Q ++ G + EE + +++ + R CL +
Sbjct: 382 HEGYMMDLTAHQGRVGNILQLGSKLIGTGKL-SEDEETEVQEQMNLLNSRWECLRVASME 440
Query: 5241 K-TNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH 5299
K +N V +L+++++ E + W+ +T+E +E + +L+ L + H
Sbjct: 441 KQSNLHRVLMDLQNQKLKE-----LNDWLTKTEERTRK--MEEEPLGPDLEDLKRQVQQH 493
Query: 5300 RQNIEKMAEEQ-KEKYLGLYTILPSELSLQLAEVALDLKIR---DQIQDKIKEVEQSKAT 5355
+ E + +EQ + L ++ E S A AL+ +++ D+ + + E
Sbjct: 494 KVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVL 553
Query: 5356 SQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKF 5415
Q++ + Q+L ++ L K D V + T E+ KL L A ++K
Sbjct: 554 LQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEK- 612
Query: 5416 LEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5475
+ +GKL L Q + +N+ S + + L+ + + +++ +EK
Sbjct: 613 ----------KKQSMGKLYSLKQDLLSTLKNK-SVTQKTEAWLDNFARCWDNLVQKLEK- 660
Query: 5476 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQV 5535
S +Q+ + Q L + T ++ +T+V E++ +
Sbjct: 661 -----------STAQISQAVTTTQPSLTQ-----------TTVMETVTTVTTREQILVKH 698
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLK 5595
A+ EEL + + + ++ K+ + ++ +L + + +++A L SPE +
Sbjct: 699 AQ-----EELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKE 753
Query: 5596 EQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHA-ALRLQEEASRLQHT 5654
S + ++ +E + K + + Q A R + +V + A +++ + +L
Sbjct: 754 GNFSDLKEKVNAIE--REKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSR 811
Query: 5655 AIQQCNIMQAAV--VQYEQ----YEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQIS 5708
I+ C ++ + ++Y+ + +++ L+Q+ A ++ +P S +++Q+
Sbjct: 812 WIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLK 871
Query: 5709 RHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTP 5768
++ ++ G Q QI L K + + +K K +G LD + +
Sbjct: 872 ICKDEVNRLSGLQPQIERL--KIQSIALKEK--------------GQGPMFLDADFVAFT 915
Query: 5769 SAHPSVVMMTAGRCHTL------LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASV- 5821
+ V R L L P+ + + + S ++ TD +
Sbjct: 916 NHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIM 975
Query: 5822 NQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSAT--AKLGDLQRSWETLKNV 5879
Q + QAL + + + + ST+ + + E S ++ +++ W+ L +
Sbjct: 976 EQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQ 1035
Query: 5880 ISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES-PEPGRSP--ESQMAEHQALM 5936
+ E + L E + + +K Q+ +Q++ M +++ L E P G S + Q+ + + L+
Sbjct: 1036 LVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLV 1095
Query: 5937 DEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQL 5996
+I +Q +N + +++ +E A+P L++ L L + + + +++
Sbjct: 1096 SDIQTIQPSLNSVNEG-GQKIKNE---AEPEFASRLETELKELNTQWDHMCQQVYARKEA 1151
Query: 5997 LEEKLNDQLEEQRQEQALQRYRCEADEL---DSWLLSTKATLDTALSPPKEPMDMEAQLM 6053
L+ L + Q+ + + +A+E + T L A+ K + Q
Sbjct: 1152 LKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKE 1211
Query: 6054 DCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALH 6113
+L E V+A + V E L E + T + + L +L +L E+ H
Sbjct: 1212 AKVKLLTESVNSVIAQAP-PVAQEALKKELETLTTNY-QWLCTRLNGKCKTLEEVWACWH 1269
Query: 6114 DKQLNMQGTAQEKEESDVDLTATQS-PGVQEWLAQARTTWTQQRQSSLQQQKELEQELAE 6172
+ ++ + E + L T++ PG E E+ + L
Sbjct: 1270 ELLSYLEKANKWLNEVEFKLKTTENIPGGAE---------------------EISEVLDS 1308
Query: 6173 QKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLH 6232
++L+R +I I A+T D G +++++EL + +W LH
Sbjct: 1309 LENLMRHSEDNPNQIRI---LAQTLTDGGVMDELINEEL----------ETFNSRWRELH 1355
Query: 6233 QEFSTKQKLLQNVLEQEQE--------QVLYSRPNRLLSGVPLYKGDVP--TQDKSAVTS 6282
+E +QKLL+ ++ QE Q + ++ L+ K D Q+ + S
Sbjct: 1356 EEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQS 1415
Query: 6283 LLDGLNQAFEEVSSQSGGAKR-----QSIHLEQKLYDGVSATSTWLD---DVEERLFVAT 6334
L + EE+ + G + I + QK VS + E+RL +
Sbjct: 1416 DLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESK 1475
Query: 6335 ALLPE------ETETCLFNQEI----------LAKDIKEMSEEMDKNKNLFSQAF-PENG 6377
+L E ET QE+ L K + E+ E++ Q +
Sbjct: 1476 MILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQT 1535
Query: 6378 DNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIIL 6437
+N +++ + L + L + V +R Q+++ L+ + ++ VL LA +
Sbjct: 1536 ENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELT 1595
Query: 6438 QKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYD 6497
++ A E + + + KE + + LK +V + L K + + +
Sbjct: 1596 KRSA--VEGMPSNLDSEVAWGKATQKEIEKQKVHLK---SITEVGEALKTVLGKKETLVE 1650
Query: 6498 ELMMIIGSR----RSGLNQNLTLKSQYERALQDL-------------ADLLETGQEKMAG 6540
+ + ++ S S + L L +Y++ ++ AD L EK
Sbjct: 1651 DKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKP 1710
Query: 6541 DQK--IIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6598
QK ++ K E+ + K + M RK++ + +EL +
Sbjct: 1711 QQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQI-------SELNHR 1763
Query: 6599 ASAVLKR--AHKRGVELEYILETWSHLDEDQQELSRQLEVVESSI-PSVGLVEE--NEDR 6653
+A+ R K + L+ L++ ++ + LE +E+ I V L EE N+D
Sbjct: 1764 FAAISHRIKTGKASIPLK-------ELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDM 1816
Query: 6654 LIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMS 6713
D + L + Q + + D+ KR I I L+++ N L + K
Sbjct: 1817 NEDNEGTVKELLQRGDNLQQR---ITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKAL 1873
Query: 6714 KELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQ-----QSVTVPQELEMVRDHL 6768
+ H+ W +Y+ ++ DL+ L + +L + + + +EL+ ++ L
Sbjct: 1874 EISHQ-------WYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEEL 1926
Query: 6769 NAFLEFSKEVDAQSSLKS-------------SVLSTGNQLLRLKKVDTATLRSELSRIDS 6815
NA ++ + + + + S Q RL T+R E + +
Sbjct: 1927 NAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMT 1986
Query: 6816 QWTDL-LTNIPA--VQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGY 6872
+ L ++ +P+ + E H Q A+ EV ++ + + ED K
Sbjct: 1987 EDMPLEISYVPSTYLTEITHVSQ--------ALLEVEQLLNAPDLCAKDFEDLFKQEESL 2038
Query: 6873 KAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSW 6932
K I + LQ+ G +IDI + T + LQ S+ VE + E L ++ W
Sbjct: 2039 KNIKDSLQQSSG-RIDIIHSKKT------AALQ-SATPVE-----RVKLQEALSQLDFQW 2085
Query: 6933 QILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK--QQHRIGDQASVQNAL 6990
+ + + ++ + +E W + +++ W E+ L+ Q + A + L
Sbjct: 2086 EKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYL 2145
Query: 6991 KDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQL 7050
K +L+D I ++ V + G +IQ + +SI+ L L W + +
Sbjct: 2146 K---ELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDR 2202
Query: 7051 KILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE 7110
K L+ + S + ++ +L EA +++ L G + ++ +++ ++ L ++L
Sbjct: 2203 KKRLEEQKNILSEFQRDLNEFVLWLEEAD-NIASIPLEPGKEQQLKEKLEQVKLLVEELP 2261
Query: 7111 KQERSLQKFGSITNQLLKEC--HPPVTETLTNTLKEVNMRW----NNLLEEIAEQLQSSK 7164
++ L++ +L P + L N LK+ N++W L E+ E K
Sbjct: 2262 LRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIK 2321
Query: 7165 ALLQLWQRYKDYSKQC------ASTVQQQEDRTNELLKAATNKDIADDEVATWIQ--DCN 7216
L QL ++ +D +Q S ++ Q + N+ + D+ + E+A + D
Sbjct: 2322 DLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGP-FDVQETEIAVQAKQPDVE 2380
Query: 7217 DLL-KGLGTVKDSLFF------LHELGEQLK------QQVDAS-----------AASAIQ 7252
++L KG K+ L +L + K Q++ A AS Q
Sbjct: 2381 EILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQ 2440
Query: 7253 SDQLSLSQHLCALEQALCKQQ--TSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPS 7310
+ L ++Q + E A+ K + +SL V F ++ L W+ +++++ Q
Sbjct: 2441 TVTL-VTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVM 2499
Query: 7311 HSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRL--PLNDKEIK-----RMQNLN 7363
DL I E + + K M P L+ L L +++E + R++ +
Sbjct: 2500 -VGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQ 2558
Query: 7364 RHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ 7423
W + R +L L +LE E + L Q KL G Y Q+
Sbjct: 2559 NQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQK 2618
Query: 7424 RAHELFQAEMFSRQQILHSIIID--GQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQ 7481
+ E Q RQ + + + +LL DD + ++ ++ W+ + +R
Sbjct: 2619 KITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVS 2678
Query: 7482 QRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKE- 7540
+R ++ R Q++ EK WL E + + ++ R L D KE
Sbjct: 2679 EREAALEETHRLLQQFPLDLEKFLAWLTEAE----TTANVLQDATRKERLLEDSKGVKEL 2734
Query: 7541 -KVFLRQQGS-------YILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLE 7591
K + QG Y E +++L S + +A LQ L + KW +
Sbjct: 2735 MKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSL 2794
Query: 7592 EQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLP--------DHHEELHAEQMRC 7643
+ L W++ + + L L+ +LS+ P ++H R
Sbjct: 2795 NIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRE 2854
Query: 7644 KELENAVGSWTDDLTQLSLLKDTLSAYIS-------------ADDIS-ILNERVELLQRQ 7689
+ + V T + ++ L + L A +++ +L ++ E + +
Sbjct: 2855 LKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTE 2914
Query: 7690 WEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQME---SKVSQNGDILIEEMIEK 7746
WE+L + +++I E L E EL L Q E GD+LI+ + +
Sbjct: 2915 WEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDH 2974
Query: 7747 LK--KDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAA 7804
L+ K + EIA +EN + + +L + + L +N RW+ L +
Sbjct: 2975 LEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLS-TLEDLNTRWKLLQVAVED 3033
Query: 7805 RVKKLKE 7811
RV++L E
Sbjct: 3034 RVRQLHE 3040
Score = 176 bits (446), Expect = 9e-43
Identities = 377/1990 (18%), Positives = 829/1990 (41%), Gaps = 261/1990 (13%)
Query: 6844 AISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSV 6903
A+ EV+SW+ E+ +Q + I N + + + + ++G+ +D+ Q V ++
Sbjct: 347 ALEEVLSWLLSAEDTLQA-QGEISNDV--EVVKDQFHTHEGYMMDLTAHQGRVG----NI 399
Query: 6904 LQISSQDVESKR---SDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
LQ+ S+ + + + ++T+ EQ+ +N W+ L+ EK L +L + +
Sbjct: 400 LQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK--L 457
Query: 6961 QCLKTWFETQEKRLK--QQHRIG-DQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7017
+ L W E+R + ++ +G D ++ ++ + L++ ++ ++ V + + +
Sbjct: 458 KELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVV 517
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7077
++ + ++ + L+ LG WAN+ +LL+ +L +W +++L E
Sbjct: 518 DESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSE 577
Query: 7078 ARYSLSRFRLLTGSLEAVQV--QVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC-HPPV 7134
++++ TG + ++ + L L+ DLEK+++S+ K S+ LL + V
Sbjct: 578 KEDAVNKIHT-TGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSV 636
Query: 7135 TETLTNTLKEVNMRWNNLLEEIAEQL-QSSKALLQLWQRYKDYSKQCASTVQQQEDRTNE 7193
T+ L W+NL++++ + Q S+A+ + TV R
Sbjct: 637 TQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQI 694
Query: 7194 LLKAATNK----------------------DIADDEVATWIQDCNDLLKG---------- 7221
L+K A + D+ E+ +WI +L+
Sbjct: 695 LVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEG 754
Query: 7222 -LGTVKDSLFFLH-ELGEQLKQQVDAS-AASAIQSDQLSLSQHLCALEQA---------- 7268
+K+ + + E E+ ++ DAS +A A+ ++ + +++QA
Sbjct: 755 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIE 814
Query: 7269 LCKQQTSLQAGVLDYET----FAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEE 7324
C Q S + L+Y+ F L+ LE AE L+ Q P+ S+ + I+ +++
Sbjct: 815 FC-QLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ-PTTPSEPTAIKSQLKI 872
Query: 7325 LKGQMLKFSSMAPDLDRLN-------ELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERF 7377
K ++ + S + P ++RL E G D + N H+ + S R
Sbjct: 873 CKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTN---HFKQVFSDVQARE 929
Query: 7378 SKLQSFL-----LQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL--FQ 7430
+LQ+ +++Q + TW++ Q+E KL++ + + +QR EL Q
Sbjct: 930 KELQTIFDTLPPMRYQETMSAIRTWVQ---QSETKLSIPQLSVTDYEIMEQRLGELQALQ 986
Query: 7431 AEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQ 7490
+ + +Q L+ + + + ++ + ++ + + +W+ + + + ++ Q
Sbjct: 987 SSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQ 1046
Query: 7491 IRQWQRYREMAEKLRKWLVEVSYL---PMSGLGSVPI---PLQQARTLFDEVQFKEKVFL 7544
+ + ++ + + L+KW+ EV LG I L+Q R L ++Q
Sbjct: 1047 MNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQ------- 1099
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
Q S E G+++ A+ + L+ EL E+ +W ++ +K+ L L+
Sbjct: 1100 TIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKT 1159
Query: 7605 EKCEKGIADSLEKLRT-----FKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQ 7659
+K +++ E + ++ PD ++ E R KE + +
Sbjct: 1160 VSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEA------K 1213
Query: 7660 LSLLKDTLSAYIS-ADDIS--ILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSE 7716
+ LL +++++ I+ A ++ L + +E L ++ LC +L+ + + + E W
Sbjct: 1214 VKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLS 1273
Query: 7717 KNKELCEWLTQMESKVSQNGDILI-EEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKA 7775
++ +WL ++E K+ +I E I ++ + + +++N Q++ + + L
Sbjct: 1274 YLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDG 1333
Query: 7776 SHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7835
+ I +L N RW+ L + R K L++++ + Q+ +K++ ++ L I+
Sbjct: 1334 GVMDEL--INEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
Query: 7836 ELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAEC 7895
+LA I D ++ ++ + E Q++Q D+ H ++L E+ H+
Sbjct: 1392 QLAAYIA-DKVDAAQMPQ---EAQKIQSDLTSHE------ISLEEMKKHNQGK------- 1434
Query: 7896 DSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSS-----ERT 7950
++ Q+ +D + + +SM+ +RL+QK + FE L+ S E
Sbjct: 1435 EAAQRVLSQIDVAQKKLQDVSMK--------FRLFQK----PANFEQRLQESKMILDEVK 1482
Query: 7951 AAFPS--SSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLK 8008
P+ + V V + +L + + E +++E++ K R++ ++ +T++ L
Sbjct: 1483 MHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELD 1542
Query: 8009 QMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS- 8067
+ V ++ L +VT ++L+ + + + + WL D++LT
Sbjct: 1543 ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEG 1602
Query: 8068 -ECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQL---IEKSEPLD------------- 8110
++ +++ KA Q+EI ++ I GE L + K E L
Sbjct: 1603 MPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIA 1662
Query: 8111 -AAIIEEELDELRRYCQ--EVFGR-VERYHKKLIRLPLPDDEHDLSDRELELED-----S 8161
+ EE L+ L Y + E F + V+ K +I+ DE + + + ED
Sbjct: 1663 VTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESE-KKKPQQKEDVLKRLK 1721
Query: 8162 AALSDLH-----WHDRSADSLLSPQPSSNLSLSLAQPLRSERSGRDTPAS------VDSI 8210
A L+D+ D++A+ + + + L +P SE + R S SI
Sbjct: 1722 AELNDIRPKVDSTRDQAANLMAN---RGDHCRKLVEPQISELNHRFAAISHRIKTGKASI 1778
Query: 8211 PLEWDHDYD-----LSRDLESAMSRALPSEDEEGQDDKDFYLRGAV--------GLSDVM 8257
PL+ ++ L LE+ + + + ++E+ D + G V L +
Sbjct: 1779 PLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRI 1838
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQ-QTENIIR------S 8310
E +K+ + ++ L SQ R+ + +Q + Q +++++
Sbjct: 1839 TDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEK 1898
Query: 8311 KTPTGPEL--DTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAG 8368
K + PE + K + L + +++V+R L E+ ++ + T+ Q +
Sbjct: 1899 KLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA----VEPTQIQLS- 1953
Query: 8369 VIDRWELLQAQ-ALSKELRMKQ----NLQKWQQFNSDLNSIWAWLGDTE-EELEQLQR-- 8420
RW ++++ A + L Q + D+ +++ T E+ + +
Sbjct: 1954 --KRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2011
Query: 8421 LELSTDIQTIELQIKKLKELQKAVDHRKAIILSINLCSPEFTQADSKESR---------- 8470
LE+ + +L K ++L K + K I S+ S SK++
Sbjct: 2012 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2071
Query: 8471 -DLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFH---EMSHGLLLMLENIDRRKN 8526
LQ+ LSQ++ +W++V + ++ +G ++ + + FH ++ + L E R+
Sbjct: 2072 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQ 2131
Query: 8527 EIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEK 8586
I N + + + K+L + + Q V +L +++ + TD +EK
Sbjct: 2132 ----IPENWEHAKYKWYLKELQD---GIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 2184
Query: 8587 VHVIGNRLKLLLKEVSRHIKELEKLLDV-SSSQQDLSSWSS-ADELDTSGSVSPTSGRST 8644
+ + R + + K++S K LE+ ++ S Q+DL+ + +E D S+ G+
Sbjct: 2185 LGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQ 2244
Query: 8645 PNRQKTPRGK 8654
++K + K
Sbjct: 2245 QLKEKLEQVK 2254
Score = 174 bits (440), Expect = 5e-42
Identities = 447/2617 (17%), Positives = 1007/2617 (38%), Gaps = 386/2617 (14%)
Query: 1251 SLEELISGSKEVQEQAEKILDTENLFEAQQL-LLHHQQKTKRISAKKRDVQQQIAQAQQG 1309
S E+ + E+ E + D + E + L HQ + I Q+ G
Sbjct: 357 SAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNIL--------QLGSKLIG 408
Query: 1310 EGGLPD----RGHEELRKLESTLDGLE-RSRERQER--RIQVTLRKWERFETNKETVVRY 1362
G L + E++ L S + L S E+Q R+ + L+ + E N + + +
Sbjct: 409 TGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELN-DWLTKT 467
Query: 1363 LFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENL------VKEASEIPLG 1416
+T E L LE L +++Q K + E V+ +L V E+S G
Sbjct: 468 EERTRKMEEEPLG-PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESS----G 522
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
L++Q K + ++ + E+ ++ + KW S W++EKE +
Sbjct: 523 DHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAV 582
Query: 1477 NALETSS--SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLT 1534
N + T+ +M S K+ + + + LE++ QS + + + K
Sbjct: 583 NKIHTTGFKDQNEMLSSLQKLAVLKAD--------LEKKKQSMGKLYSLKQDLLSTLKNK 634
Query: 1535 QIRRYGEE-LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSAT 1593
+ + E L A+C + + QK E++ +I Q+V+ + L T
Sbjct: 635 SVTQKTEAWLDNFARCWDNLV-------QKLEKSTAQISQAVTTTQPSL----------T 677
Query: 1594 ETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKER 1653
+T +E++++ T R+ + +E Q K+R
Sbjct: 678 QT-----------TVMETVTTVTT------REQILVKHAQEELPPPPPQ--------KKR 712
Query: 1654 QTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1713
Q +++ + +RL+ +++ +W+ R EA SPE I + + A++ E
Sbjct: 713 QITVDSEIR--KRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIERE- 769
Query: 1714 VSQASFYSKLLQLKESLFSVASKD-----DVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1768
+A + KL S ++ + + +K EQL+ RW + Q++++R+N+L+
Sbjct: 770 --KAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLE 827
Query: 1769 ---SVVA---EHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVES 1822
+++A + QQ +++ + W+K+ + T SE + + Q+ + KD +
Sbjct: 828 YQNNIIAFYNQLQQLEQMTTTAENWLKI---QPTTPSEPTAIKSQLKIC--KDEVNRLSG 882
Query: 1823 KKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFL- 1881
+ +++ L+ L G+ L F++ V+ R+ L + + L
Sbjct: 883 LQPQIERLKIQSIALKEKGQGP--MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLP 940
Query: 1882 --QSHASLSGILRQLRQ--TVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGIL 1937
+ ++S I ++Q T + ++ + +++E+ L + +L+ L +
Sbjct: 941 PMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLS 1000
Query: 1938 SKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEEL 1997
+ + K SE ++ +++ G +++ + L + + + Q+ + L
Sbjct: 1001 TTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTL 1060
Query: 1998 LKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIA-QKD 2056
K + +++ +E + L+++L+ L ++ + + L + + ++I + +
Sbjct: 1061 KKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAE 1120
Query: 2057 VAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVI 2116
FA ++ E+ L WD + ++ + G ++ Q S + + + A
Sbjct: 1121 PEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180
Query: 2117 VTRT-TIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVK 2175
+ R K ++L+ A + + AK + K+ + T ++++ + +K
Sbjct: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ---EALK 1237
Query: 2176 TDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLD 2235
++E+ + + +L L + W ++LS ++ W N ++ + +
Sbjct: 1238 KELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLN----EVEFKLKTTE 1293
Query: 2236 NHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHA 2295
N E + E ++N E+ +++ L + + +L E +
Sbjct: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRE 1353
Query: 2296 KEITEVAKGTLKDFTAQSTQ-VEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQK 2354
V + L + + QS Q EK ++ I T +++ L ++ A + +
Sbjct: 1354 LHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAA-----QMPQ 1408
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
E Q QS+++S + +L + K H+ E+ R ++ + + + + K + + +
Sbjct: 1409 EAQKIQSDLTSHEISLEEM--KKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPA- 1465
Query: 2415 EKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVT 2474
+F + +QE + K ++ + +V++++L+ N+ S+S+ +S+++ V
Sbjct: 1466 --NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVI 1523
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
+ G+ + + + E++T + + + KQ L+ C + L
Sbjct: 1524 KTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVL 1583
Query: 2535 NLWI----HEMEERFNTENL----------GESKQHIPEKK----NEVHKVEMFLGELLA 2576
W+ E+ +R E + G++ Q EK+ + +V L +L
Sbjct: 1584 TEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLG 1643
Query: 2577 ARESL--DKLS------------------------------------------QRGQLLS 2592
+E+L DKLS Q LL
Sbjct: 1644 KKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLD 1703
Query: 2593 EEGHGAGQEGRLCSQLLTSHQNLLR----MTKEKLRSCQVALQEH--EALEEALQSMWFW 2646
E Q+ + L + N +R T+++ + +H + +E + +
Sbjct: 1704 ESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHR 1763
Query: 2647 VKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAI-------------- 2692
AI R+ ++++ K+ LE+ S IQ LL E E++ + +
Sbjct: 1764 FAAISHRIKTGKASIPLKE-LEQFNSDIQK-LLEPLEAEIQQGVNLKEEDFNKDMNEDNE 1821
Query: 2693 GKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLES--------VISQWND 2744
G ++ L+ + QR+ + ++ ++ + +A L S + QW
Sbjct: 1822 GTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQ 1881
Query: 2745 YVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFV------LLDHLQSILSEAEDHTRALH 2798
Y + + L + ++ +++K+ +P+ K K + + L ++ +AE +
Sbjct: 1882 YKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGA 1941
Query: 2799 RLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHE 2858
+ + ++ + + + F I TV +E M + E + + Y+ + +
Sbjct: 1942 AMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTY- 2000
Query: 2859 FTDWLHSAK-----EELHRWSDM-SGDSSATQKKLSKIKELIDSREIGASRLSRVESLAP 2912
T+ H ++ E+L D+ + D K+ +K + DS + + R+ + S
Sbjct: 2001 LTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKT 2060
Query: 2913 EVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQL 2972
Q+ T + + L W++ V++M Q G+ +
Sbjct: 2061 AALQSATPVERVKLQEALSQLDFQWEK---------------VNKMYKDRQ---GRFDRS 2102
Query: 2973 EQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKG------QEILDALQKAEPRTEDL 3026
+ +F +K + Q LT E +I E W +E+ D + + + L
Sbjct: 2103 VEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTL 2162
Query: 3027 KSQLNELCRFS--RDLSTYSGKVSGLIKEYNCLCLQAS---KGCQNKEQILQQRFRKAFR 3081
+ E+ + S D S K+ L + +C Q S K + ++ IL + F++
Sbjct: 2163 NATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSE-FQRDLN 2221
Query: 3082 DFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKG--ELLS 3139
+F WL A + + P ++ L++++ + E Q L + G L+S
Sbjct: 2222 EFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVS 2280
Query: 3140 TLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALE-------NLKIQMKDFEVSAEPI 3192
++ E+ ++ K+ W L +K+ +E L+ +++D E +
Sbjct: 2281 APISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHL 2340
Query: 3193 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3252
WLS + +Y+ P + +Q + +P + + K Q L++ +
Sbjct: 2341 LLWLSPIRNQL-----EIYNQP-NQEGPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKP 2394
Query: 3253 ASKSFRHRVSQLSSQYLALSNLTKEKVSR-------LDRIVAEHNQ-------------- 3291
A++ + ++ LSS++ A++ L +E ++ L I A Q
Sbjct: 2395 ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2454
Query: 3292 --------------------FSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLE 3331
F+ EL DW++ ++ S D ++ +K +
Sbjct: 2455 AISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQK 2514
Query: 3332 ALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT-IQQQLQSVKDMWASLLSAGIRCKSQ 3390
A + +++ Q++ ++T +++ TS + T I +++ +++ W + + Q
Sbjct: 2515 ATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQ 2574
Query: 3391 LEGAL---SKWTSYQDGVRQFSG--------W------MDSMEANLNESERQHAELRDKT 3433
L L ++W ++ Q G W +D+++ + E+++ +LR
Sbjct: 2575 LNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQ 2634
Query: 3434 TMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTK 3493
T + A L ++L S +T +V H +T +++ +R+I +R E
Sbjct: 2635 TNVDVANDLALKLLRDYSADDTRKV-------HMIT----ENINASWRSIHKRVSEREAA 2683
Query: 3494 SEKLVRLHQEYQRDLKAFEVWLGQEQ-----------------------EKLDQYSVLEG 3530
E+ RL Q++ DL+ F WL + + E + Q+ L+G
Sbjct: 2684 LEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQG 2743
Query: 3531 DAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQ 3590
+ H +L E Q +L S+ + + V+ R L+++ W +
Sbjct: 2744 EIEAHTDVYHNLDE------NSQKILRSLEGSDDAVL-------LQRRLDNMNFKWSELR 2790
Query: 3591 HRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEK 3627
+ R+ ++ + + Q++ WL+ +++
Sbjct: 2791 KKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDE 2827
Score = 167 bits (423), Expect = 4e-40
Identities = 525/3002 (17%), Positives = 1145/3002 (38%), Gaps = 438/3002 (14%)
Query: 4070 ELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEK----- 4124
E+ +L A+ LQ +++E + ++ + ++ L + Q V I++
Sbjct: 350 EVLSWLLSAEDTLQAQGEISNDVE--VVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLI 407
Query: 4125 -VNKLTKKEESPEHKEINHLNDQW-----LDLCRQSNNLCLQREEDLQRTRDYHDCMNVV 4178
KL++ EE+ +++N LN +W + +QSN + + Q+ ++ +D +
Sbjct: 408 GTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKT 467
Query: 4179 EVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLD 4238
E + + + E LE LK+ +Q+ K EDL+ Q+ + +L
Sbjct: 468 E----------ERTRKMEEEPLGPDLEDLKR---QVQQHKVLQEDLE---QEQVRVNSLT 511
Query: 4239 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4298
+V +++S + LE E+L V+ R+ + W E++
Sbjct: 512 HMVVVVDESSG-DHATAALE--------------EQLKVLGDRWANICRWTEDRWV---- 552
Query: 4299 ALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSD 4358
LL D L L +Q L + + + + + + + + LS
Sbjct: 553 -------------LLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSS 599
Query: 4359 AQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDD- 4417
Q +DL ++++ + K S K Q L++ + S Q+ E + ++ D+
Sbjct: 600 LQKLAVLKADLE-KKKQSMGKLYSLK-QDLLSTLKNKSVTQKTEAWL---DNFARCWDNL 654
Query: 4418 VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQ 4477
V K K+ ++ T Q +T E + VT +E+ V +EL
Sbjct: 655 VQKLEKSTAQISQAVTTTQPSLTQTTVM--ETVTTVTTREQILVKHAQEELPP------- 705
Query: 4478 KCSHRLQELEKNLVSRKHFKEDFDKACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQN 4536
+ +++ + RK D + W+ +++ ++ PE + + K
Sbjct: 706 PPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNA 765
Query: 4537 ILEQSPEYENLLLTLQRTGQTILPSL-----NEVDHSYLSEKLNALPRQFNVIVALAKDK 4591
I + E L R+ Q ++ + N SE+LN+ +F +++ +
Sbjct: 766 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNW 825
Query: 4592 FYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDE 4651
I + L ++TT + + L+ Q S+ PT A++ L + C+ ++
Sbjct: 826 LEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSE-PT--AIKSQLKI---CKDEVNR 879
Query: 4652 VAGLGEAVDELNQKKEGFRSTGQ-PWQPDKMLHLVTLYHRLK----RQTEQRVSLLEDTT 4706
++GL ++ L + + GQ P D T + + + E+ + + DT
Sbjct: 880 LSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL 939
Query: 4707 SAYQEHEKMC------QQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIV 4760
+ E M QQ E +L Q V + + E++L +L SLQ+
Sbjct: 940 PPMRYQETMSAIRTWVQQSETKLSI---PQLSVTDYEI-MEQRLGELQALQSSLQEQQSG 995
Query: 4761 LKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQT 4820
L ++ +++++ K + + + +G K L+S + E + E +M + Q
Sbjct: 996 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1055
Query: 4821 EMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEK 4880
+ W+ V L + + +++++++ ++ ++Q+ +N+++ ++
Sbjct: 1056 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
Query: 4881 FTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLED 4940
+A+ ++ LE L EL+ + + + R+ L + + ++W+
Sbjct: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
Query: 4941 AQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIK---PTGK 4997
A+E + + ++ +E K+ E +++ ++ L +++ +I P +
Sbjct: 1176 AEE--EYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQ 1233
Query: 4998 EDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFS 5057
E L++++ +L Q + + L+ A WH+ E+ + +N+ E F
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE-----FK 1288
Query: 5058 LLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLE-----KTGNDASKATLSR 5112
L T + E++SE V++S + E+ +Q+ T ++
Sbjct: 1289 LKTTENIPGGAEEISE------VLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINE 1342
Query: 5113 SMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKAS 5172
+ T RW L A ++K+LE ++ + E + + +L A+K
Sbjct: 1343 ELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVD 1402
Query: 5173 KAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDR 5232
A++ ++ Q L +S L++ G+E Q + + D
Sbjct: 1403 AAQMP-------------QEAQKIQSDLTSHEIS-LEEMKKHNQGKEAA--QRVLSQIDV 1446
Query: 5233 CLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIE--------IDA 5284
+ V +L ++ E ++ K + E K +L P +E + +
Sbjct: 1447 AQKKLQDVSMKFRLFQKPAN----FEQRLQESKMILDEVKMHL--PALETKSVEQEVVQS 1500
Query: 5285 QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQD 5344
QL L + + +E + + ++ T P EL ++ + L +++
Sbjct: 1501 QLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY---NELGA 1557
Query: 5345 KIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG---- 5400
K+ E +Q +LSR+++K +LT+ A TD + ++ + + LD
Sbjct: 1558 KVTERKQQLEKCLKLSRKMRKEMN----VLTEWLAATDMELTKRSAVEGMPSNLDSEVAW 1613
Query: 5401 --CNSKLMELDAAVQKFLEQNGQ-----LGKPLAKKIGKLTELHQQTIR---QAENRLSK 5450
K +E K + + G+ LGK KL+ L+ I +AE L+
Sbjct: 1614 GKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNL 1673
Query: 5451 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5510
L + H+E +++ ++ I KWI +A L + Q +E + + L E +I
Sbjct: 1674 LLEYQKHMETFDQNVDHITKWIIQADTLLDESE--KKKPQQKEDVL--KRLKAELNDIRP 1729
Query: 5511 ELEAMTEKLQYLTSV---YCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFE 5567
++++ ++ L + +C + + Q++EL + IK ++ K++++F
Sbjct: 1730 KVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIP--LKELEQFN 1787
Query: 5568 AELKKLQAALE---QAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKV------QAV 5618
++++KL LE Q L + + ++ + LL ++L+ ++ + +
Sbjct: 1788 SDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1847
Query: 5619 QLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH 5678
++ Q L+ + + L + +++A + H Q + + E+++
Sbjct: 1848 KIKQQLLQTKHNALKDL-----RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLAS 1902
Query: 5679 L-----QQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASL--NSKC 5731
L ++ I+ RE++ K + ++ QA+ + A ++ Q Q++ +
Sbjct: 1903 LPEPRDERKIKEIDRELQKKKEELNAVRR-QAEGLSEDGAAMAVEPTQIQLSKRWREIES 1961
Query: 5732 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTE 5791
K + + + TV E E + TED+ E+ PS + + + T +S
Sbjct: 1962 KFAQFRRLNFAQIHTVRE-ETMMVMTEDMPLEISYVPSTYLTEI--------THVSQALL 2012
Query: 5792 ESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQ 5851
E +++P C ++I S+ R+ IH +A+
Sbjct: 2013 E-----VEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDI----IHSKKTAAL 2063
Query: 5852 EFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAI 5911
+ P L L WE + + ++Q ++E+ +++ ++ + +
Sbjct: 2064 QSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEA 2123
Query: 5912 ELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQ------SSLAEELVSESCEAD 5965
E L ++ P + EH + LQD I + Q ++ EE++ +S + D
Sbjct: 2124 EQFLRKTQIP------ENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTD 2177
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+ LQ L L R + + S +++ LEE Q+ L ++ + +E
Sbjct: 2178 AS---ILQEKLGSLNLRWQEVCKQLSDRKKRLEE----------QKNILSEFQRDLNEFV 2224
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
WL L P KE ++ +L + ++ E+ + L +L+ +L+
Sbjct: 2225 LWLEEADNIASIPLEPGKE-QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPI 2283
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQE--KEESDVDLTATQSPGVQE 6143
+ +E ++L KL++ +++ RAL +KQ ++ ++ + E ++ Q +
Sbjct: 2284 -SPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLL 2342
Query: 6144 WLAQART---TWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDA 6200
WL+ R + Q Q +E E + ++ + + S+G+ +
Sbjct: 2343 WLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQPDVEEILSKGQHLY------------ 2390
Query: 6201 GEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNR 6260
EKP A ++ K E L E+ +LLQ + ++ +
Sbjct: 2391 KEKP---------------ATQPVKRKLEDLSSEWKAVNRLLQELRAKQPD--------- 2426
Query: 6261 LLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6320
L G+ G PTQ + VT + A ++ S S+ LE +
Sbjct: 2427 LAPGLTTI-GASPTQTVTLVTQPVVTKETAISKLEMPS------SLMLEVPALADFNRAW 2479
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
T L D L + + +Q ++ D+++++E + K K
Sbjct: 2480 TELTDWLSLL-----------DQVIKSQRVMVGDLEDINEMIIKQKATMQD--------- 2519
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKL 6440
+ QR Q++E + N +N TS + + II
Sbjct: 2520 --------------------LEQRRPQLEELITAAQNLKNK-----TSNQEARTII---- 2550
Query: 6441 ANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELM 6500
++IE IQ D ++E LQ + + E+ K
Sbjct: 2551 --------TDRIERIQNQWDEVQE-------------HLQNRRQQLNEMLK--------- 2580
Query: 6501 MIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKE--EIQQLLDK 6558
Q L K + E+ L LE+ +E G + K+ E +QL
Sbjct: 2581 --------DSTQWLEAKEEAEQVLGQARAKLESWKE---GPYTVDAIQKKITETKQLAKD 2629
Query: 6559 HKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILE 6618
+++ ++ L L R + +K + A ++ KR +R LE E
Sbjct: 2630 LRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALE---E 2686
Query: 6619 TWSHLDEDQQELSRQLEVVESSIPSVGLVEE--NEDRLI-------DRITLYQHLKSSLN 6669
T L + +L + L + + + ++++ ++RL+ + + +Q L+ +
Sbjct: 2687 THRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIE 2746
Query: 6670 EYQPKLYQVLDDGKRLLISISCSD----LESQLNQLGECWLSNTNKMSKELHRLETILKH 6725
+ + + ++ +++L S+ SD L+ +L+ + W K LE
Sbjct: 2747 AHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQ 2806
Query: 6726 WTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLK 6785
W R +L+ WLQ D L + + + V+ + F +E+ + +
Sbjct: 2807 WKRLHLSLQELLVWLQLKDDEL----SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVI 2862
Query: 6786 SSVLSTGNQLLRLKKVD---------------------TATLRSELSRIDSQWTDLLTNI 6824
S L T L + ++ T LR + ++++W L +
Sbjct: 2863 MSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHS 2922
Query: 6825 PAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKG 6884
Q K+ + +++L ++ + + L + + K + ++ ++L+K K
Sbjct: 2923 ADWQRKIDE-TLERLQELQEATDELD-LKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKA 2980
Query: 6885 FKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQ 6944
+ +I + V VN Q+++ ++ + + + +N W++LQ V ++++
Sbjct: 2981 LRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLED----LNTRWKLLQVAVEDRVR 3036
Query: 6945 LL 6946
L
Sbjct: 3037 QL 3038
Score = 162 bits (409), Expect = 2e-38
Identities = 468/2591 (18%), Positives = 974/2591 (37%), Gaps = 351/2591 (13%)
Query: 607 EVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKML-------NQSENAKKDFFRNLPH 659
E +S S L E N DRY + + +WL AE L N E K F + +
Sbjct: 326 EDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGY 385
Query: 660 WIQQHTAMNDAGNFL--------IETCDEMVSRDLKQQLLLLNGRW---RELFMEVKQYA 708
+ GN L E ++++Q+ LLN RW R ME +
Sbjct: 386 MMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNL 445
Query: 709 QADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQ-------DLEDIEQ 761
MD ++ + L+ K EPL ++K +Q DLE +
Sbjct: 446 HRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQV 505
Query: 762 RVPVMDAQYKIITKTAHLITKESPQEEGK---EMFATMSKLKE--------------QLT 804
RV + ++ +++ + +E+ K + +A + + E +LT
Sbjct: 506 RVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565
Query: 805 KVKECYSPLLYESQQLLIPLEELE-KQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 863
+ + +S L E + + + K SL K+ + LE++ QS Q
Sbjct: 566 EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQ 625
Query: 864 ELLACQENCKKT-----------------LTLIEKGSQSVQKFVTLSNVLKHFDQTRLQR 906
+LL+ +N T + +EK + + + VT + QT +
Sbjct: 626 DLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQ--PSLTQTTVME 683
Query: 907 QIADIHVAFQSMVKKTGDW--------KKHVETNSRLMKKFEESRAELEKVLRIAQEGLE 958
+ + Q +VK + K+ + +S + K+ + EL + ++ L+
Sbjct: 684 TVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ 743
Query: 959 EKGDPEELLRRHTEFFSQLDQRVLNAF----------LKACDELTDILPEQ------EQQ 1002
PE + R FS L ++V NA L+ L EQ
Sbjct: 744 S---PEFAIFRKEGNFSDLKEKV-NAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNAD 799
Query: 1003 GLQEAVRKLHKQWKD---LQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQE 1059
+++A +L+ +W + L E L + + L +E+ T + K+ P
Sbjct: 800 SIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTT 859
Query: 1060 GSEKI-IKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1118
SE IK D+ RL ++ +L ++ G + L A
Sbjct: 860 PSEPTAIKSQLKICKDE------VNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVA 913
Query: 1119 IDSTYRKLMEDPDKWKD-------------YTSRFSEFSSWISTNETQLKGIKGEAIDTA 1165
+ ++++ D + Y S +W+ +ET+L + D
Sbjct: 914 FTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYE 973
Query: 1166 NHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALV 1225
+ ++ +++ + ++ L +L + +K +++ + ++K E ++ +K L
Sbjct: 974 IMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLS 1033
Query: 1226 TLLSE----VEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENL---FEA 1278
+ L E +E+ ++ + + +K + E+ ++E+ + D+E L +
Sbjct: 1034 SQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV---DVFLKEEWPALGDSEILKKQLKQ 1090
Query: 1279 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQ 1338
+LL+ Q + + Q+I + E R EL++L + D + + +
Sbjct: 1091 CRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPE--FASRLETELKELNTQWDHMCQQVYAR 1148
Query: 1339 ERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTES 1398
+ ++ L K + + + ++ Q + E +L EL++ E KR +
Sbjct: 1149 KEALKGGLEKTVSLQKDLSEMHEWMTQ---AEEEYLERDFEYKTPDELQKAVEEMKRAKE 1205
Query: 1399 IAVQAENLVKEASE------IPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVK 1452
A Q E VK +E P ++ L+++ +++ + L L KT+E V
Sbjct: 1206 EAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265
Query: 1453 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEE 1512
W S E + W+ E E +L E + +I + +E+ +
Sbjct: 1266 ACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAE----EISEVLDSLENLMRHSEDNPN 1321
Query: 1513 EAQSFAQFVTTG--ESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1570
+ + AQ +T G I +L EL E A + + + Q+ E++L
Sbjct: 1322 QIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHL 1381
Query: 1571 IQQSVSEFEDKLAVPI--------------KICSSATE---TYKVLQEHMDLCQALESLS 1613
IQ+S++ + +LA I KI S T + + +++H +A + +
Sbjct: 1382 IQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVL 1441
Query: 1614 SAITAFSASARKVVNRDSCVQEAAALQQQYED---ILRRAKERQTALENLLAHWQRLEKE 1670
S I + V + Q+ A +Q+ ++ IL K ALE + ++ +
Sbjct: 1442 SQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQ 1501
Query: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
L+ + + S EM I R Q++Q Q E +
Sbjct: 1502 LNHCVNLYKSLSEVKSEVEMVIKTGR-------QIVQKKQTENPKELD------------ 1542
Query: 1731 FSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKL 1790
+ V +KLH +L + + Q + K + + + E E W+
Sbjct: 1543 ------ERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTE-------WLAA 1589
Query: 1791 FLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ 1850
EL S + M + A ++ + E++ + HL + +G A L +
Sbjct: 1590 TDMELTKRSAVEGMPSNL-----DSEVAWGKATQKEIEKQKVHLKSITEVGEA--LKTVL 1642
Query: 1851 GKAEDCFQLFEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVE-ATNSMNKNE 1908
GK E L E+ ++ +A+ S E+L + Q V+ T + + +
Sbjct: 1643 GKKE---TLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQAD 1699
Query: 1909 SDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVER 1968
+ L E + Q L+ L+ I K + +Q + A C
Sbjct: 1700 TLLDESEKKKPQQKEDVLKRLKAELNDIRPKVD-----STRDQAANLMANRGDHC----- 1749
Query: 1969 IQNLLGTKQSEAD-ALAVLKKAFQDQKEEL-LKSIEDIEERTDKERLKEPTRQALQQRLR 2026
+ L+ + SE + A + + K + LK +E +D ++L EP +QQ +
Sbjct: 1750 -RKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQF--NSDIQKLLEPLEAEIQQGVN 1806
Query: 2027 V----FNQLEDELNSHEHELCWLKDKAKQIAQK--DVAFAPEVDREINRLEVTWDDTKRL 2080
+ FN +D +E + L + + Q+ D E+ + L+ + K L
Sbjct: 1807 LKEEDFN--KDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDL 1864
Query: 2081 IHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKN 2140
+ + + + +Y+ + K L++ + + +D+ +K + + K
Sbjct: 1865 RSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKE 1924
Query: 2141 KMNYKQKDLDNFTSKGKHLLSELKKIHSS----------------DFSLVKTDMESTVDK 2184
++N ++ + + G + E +I S +F+ + T E T+
Sbjct: 1925 ELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETM-- 1982
Query: 2185 WLDVSEKLEENMDRL-RVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEEL 2243
+ ++E + + + L+ V E+E N P + + ++ + EE
Sbjct: 1983 -MVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN--APDLC--AKDFEDLFKQEES 2037
Query: 2244 LKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAK 2303
LK + ++ + R++ +HSK K TP + ++ L Q +++ ++ K
Sbjct: 2038 LKNIKDSLQQSSGRIDIIHSK----KTAALQSATPVERVKLQEALSQLDFQWEKVNKMYK 2093
Query: 2304 GTLKDFTAQSTQVEKFINDI---TTWFTKVEESLMNCAQNETCEALK---KVKDIQKELQ 2357
F + +F DI W T+ E+ L E E K +K++Q +
Sbjct: 2094 DRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIG 2153
Query: 2358 SQQSNISSTQENLNSLCRKYHSAELESLGRAMTGL-IKKHEAVSQLCS-KTQASLQESLE 2415
+Q+ + + + ++ + L + L ++ E QL K + Q+++
Sbjct: 2154 QRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNIL 2213
Query: 2416 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQ 2475
F + EF W A A + G + L+ KL ++ +++ + Q L + +
Sbjct: 2214 SEFQRDLNEFVLWLEEADNIASIPLE-PGKEQQLKEKLEQVKLLVEELPLRQGILKQLNE 2272
Query: 2476 EGQTLY--AHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2533
G + A +S + ++ ++ + N Q +K +AL + E+ +
Sbjct: 2273 TGGPVLVSAPISPEEQDKLENKLKQTN-------LQWIKVSRALPEKQGEIEA------- 2318
Query: 2534 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
++LG+ ++ + + + +++ + ++L + E ++ +Q G +
Sbjct: 2319 ------------QIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQ 2366
Query: 2594 EGHGAGQEGRL-CSQLLTSHQNLLR---MTKEKLRSCQVALQEHEALEEALQSMWFWVKA 2649
E A Q + ++L+ Q+L + T+ R + E +A+ LQ + +A
Sbjct: 2367 ETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQEL----RA 2422
Query: 2650 IQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM--AIGKGEQALRSSNKEGQ 2707
Q LA +T+G+ T + ++ + ++ K KL M ++ AL N+
Sbjct: 2423 KQPDLAPGLTTIGASPT--QTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT 2480
Query: 2708 RVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPL 2767
+ W ++ + +Q + + N+ + ++ Q +E
Sbjct: 2481 ELTD---------WLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLE---------- 2521
Query: 2768 QPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQ 2827
Q +P L+E +L++ S E T R+ E ++ Q
Sbjct: 2522 QRRPQLEELITAAQNLKNKTSNQEARTIITDRI---------------------ERIQNQ 2560
Query: 2828 FNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKL 2887
++++ + + +++ E++KD +L+A E L A+ +L W + A QKK+
Sbjct: 2561 WDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKI 2620
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2947
++ K+L + + LA ++ ++ +A +H + + A W+ V +
Sbjct: 2621 TETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSER 2680
Query: 2948 QSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVE 3004
++ LE L+ Q L ++F +A L +A E + +L+ ++ LLE +E+++
Sbjct: 2681 EAALEETHRLLQQFPLDLEKF---LAWLTEA-ETTANVLQDATRKERLLEDSKGVKELMK 2736
Query: 3005 CWHKGQEILDA 3015
W Q ++A
Sbjct: 2737 QWQDLQGEIEA 2747
Score = 159 bits (402), Expect = 1e-37
Identities = 580/3108 (18%), Positives = 1159/3108 (37%), Gaps = 547/3108 (17%)
Query: 2753 EQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTE 2812
+Q S+ Q E P+P +F + Q+ D TR+ S+ L E E
Sbjct: 276 QQITVSLAQGYERTSSPKP----RFKSYAYTQAAYVTTSDPTRSPF----PSQHL-EAPE 326
Query: 2813 DESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHR 2872
D+SF + E + + T +E + + L A E ++ + K++ H
Sbjct: 327 DKSFGSSLMES-EVNLDRYQTALEEVLSWLLSAEDT----LQAQGEISNDVEVVKDQFHT 381
Query: 2873 WSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQA 2932
D +A Q ++ I +L S+ IG +LS E + + N L+++ +
Sbjct: 382 HEGYMMDLTAHQGRVGNILQL-GSKLIGTGKLSEDEETEVQEQMN-------LLNSRWEC 433
Query: 2933 LRADWKQWEDSVFQTQSCLENLVSQ-------------MALSEQEFSGQVAQLEQALEQF 2979
LR + + ++ + L+N + + E+ + L++ ++Q
Sbjct: 434 LRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQH 493
Query: 2980 SALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRD 3039
L + Q+ + T +V G AL E + + L + +CR++ D
Sbjct: 494 KVLQEDLEQEQVRVNSL-THMVVVVDESSGDHATAAL---EEQLKVLGDRWANICRWTED 549
Query: 3040 ----LSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTA 3095
L K L +E CL S KE + + F+D
Sbjct: 550 RWVLLQDILLKWQRLTEE-QCLF---SAWLSEKEDAVNKIHTTGFKD------------- 592
Query: 3096 KCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLS-KGELLSTLLTKEKAKGIQAKV 3154
QN E+ +SLQK+ ++ E + + + S K +LLSTL K K + K
Sbjct: 593 ------QN--EMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTL----KNKSVTQKT 640
Query: 3155 TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLP 3214
A +++ NL QK LE Q+ + +P S T+ V E+ +
Sbjct: 641 EAWLDNFARCWDNLVQK---LEKSTAQISQAVTTTQP-----SLTQTTVMETVTTV---- 688
Query: 3215 AKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNL 3274
REQ ++ EE+ PQ R Q S +
Sbjct: 689 -TTREQILVKHAQEELPPPPPQKKR---------------------------QITVDSEI 720
Query: 3275 TKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDS--YCHPTSDKSVLDSRTLKLEA 3332
K RLD + I EL W+T + +L S + + + D + K+ A
Sbjct: 721 RK----RLD----------VDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKE-KVNA 765
Query: 3333 LLSVKQEKEIQMKMIVTRGESVLQNTSPEGI--PTIQQQLQSVKDMWASLLSAGIRCKSQ 3390
+ K EK +++ +++++ EG+ +I+Q + + W Q
Sbjct: 766 IEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFC--------Q 817
Query: 3391 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESER----QHAELRDKTTMLGKAKLLNEEV 3446
L W YQ+ + F + +E +E Q + T + + K+ +EV
Sbjct: 818 LLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEV 877
Query: 3447 LSYSSL---LETIEVKGAGMTEHYVTQLELQ--------DLQERYRAIQERAKEAVTKSE 3495
S L +E ++++ + E + L ++ + +Q R KE T +
Sbjct: 878 NRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFD 937
Query: 3496 KLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQA- 3554
L + YQ + A W+ Q + KL + D E L +LQ LQ E Q+
Sbjct: 938 TLPPMR--YQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSG 995
Query: 3555 --LLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQ 3612
L++ + PS I + E + W+ +L E + +NKLR ++
Sbjct: 996 LYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQN 1055
Query: 3613 KFQQVDEWLKTAE---EKKWH-------------------EEVTAYRDEVEEVGARAQEI 3650
Q + +W+ + +++W ++ + + V Q+I
Sbjct: 1056 HIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKI 1115
Query: 3651 LDESHVN--SRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGS 3708
+E+ SR+ + +L +++ + QV + + L+ ++ + LS +W
Sbjct: 1116 KNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQ 1175
Query: 3709 THKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEA 3768
+ + + + KT + L K +E+ +K A+E+ ++ +E +
Sbjct: 1176 AEEEY------------LERDFEYKTPDELQKAVEE----MKRAKEEAQQ-----KEAKV 1214
Query: 3769 ERLRKEIHDHMEQLKELTS-TVRKEHMTLEKGLH-LAKEFSDKCKALTQWIAEYQEILHV 3826
+ L + ++ + Q + ++KE TL L + KCK L + A + E+L
Sbjct: 1215 KLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSY 1274
Query: 3827 PEEPKMELYEKKAQLSKYK--------------SLQQTVLSHEPSVKSVREKGEALLEL- 3871
E+ L E + +L + SL+ + E + +R + L +
Sbjct: 1275 LEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGG 1334
Query: 3872 VQDVTLKDKIDQLQSDYQDLCSIG----KAMMEEIAGFEDRLNNLQMKGDTLI------- 3920
V D + ++++ S +++L K + + I ++ +L + ++L
Sbjct: 1335 VMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLA 1394
Query: 3921 GQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHVSRQDTLQQCQAW 3980
AD + A +Q S+ SLE E++KH ++ Q+ +
Sbjct: 1395 AYIADKVDAAQMPQEAQKIQSDLTSHEI----------SLE-EMKKHNQGKEAAQRVLSQ 1443
Query: 3981 LSAVQPDLEPSP------QPPLSRAEAIKQVK--------HFRAL------QEQARTYLD 4020
+ Q L+ Q P + + +++ K H AL QE ++ L+
Sbjct: 1444 IDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLN 1503
Query: 4021 LLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLK---SELWIYLQD 4077
C S + VK+ + + +T + I QK Q +N + E + LK +EL + +
Sbjct: 1504 H-CVNLYKSLSEVKSEVEMVIKTGRQIVQKK-QTENPKELDERVTALKLHYNELGAKVTE 1561
Query: 4078 ADQQLQNMKR--RHSELELNIAQNMV----------SQVKDFVKKLQSKQA--------- 4116
QQL+ + R E+N+ + S V+ L S+ A
Sbjct: 1562 RKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEI 1621
Query: 4117 --------SVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSN---NLCLQREEDL 4165
S+ + E + + K+E+ +++ LN W+ + ++ NL L+ ++ +
Sbjct: 1622 EKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHM 1681
Query: 4166 QRTRDYHDCMNVVEVFLEKFTTEWDNLA-RSDAESTAVHLEALKKLALALQERKYAIEDL 4224
+ D + K+ + D L S+ + + LK+L L + + ++
Sbjct: 1682 ETFDQNVD-------HITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDST 1734
Query: 4225 KDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKR-KIQVSVTNLEELNVVQSRFQ 4283
+DQ ++ + ++LV+ Q S L R+ + IK K + + LE+ N +
Sbjct: 1735 RDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLL 1794
Query: 4284 ELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMAD 4343
E +E +Q N+ E D +++ D+ EL + L+ I D
Sbjct: 1795 EPLEAEIQQGVNLKEE-------DFNKDMNEDNEGTVKELLQRGDNLQQRITDE------ 1841
Query: 4344 LGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHER 4403
+R+ I+ Q+ N L DL QRRK KAL Q+ QA ++ +
Sbjct: 1842 ---RKREEIKIKQQLLQTKHNALKDLRSQRRK---KALEISHQWYQYKRQADDLLKCLDD 1895
Query: 4404 KIMFREHICLLPDD-----VSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEK 4458
+ + LP+ + + + + + L + + GL G + E T+ +
Sbjct: 1896 ---IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQL 1952
Query: 4459 SEVLGKLQELQSVYDSVLQKCSHRLQE-----------LEKNLVSRKHFKEDFDKACHWL 4507
S+ +++ + + + H ++E LE + V + E + L
Sbjct: 1953 SKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALL 2012
Query: 4508 KQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDH 4567
+ ++ P++ + +L Q +NI + + + + L S V+
Sbjct: 2013 EVEQLLNAPDL-CAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVER 2071
Query: 4568 SYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMS 4627
L E L+ L Q+ + + KD+ + ++ + + I++ Q L+E E QFLR +
Sbjct: 2072 VKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE-QFLRKT 2130
Query: 4628 KVPTDLAVEE----ALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLH 4683
++P + + LQDG V L +E+ Q+ T +K+
Sbjct: 2131 QIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSS---KTDASILQEKLGS 2187
Query: 4684 LVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEK 4743
L + + +Q R LE+ + E ++ + L+ N ++P E
Sbjct: 2188 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEAD------NIASIPLEP- 2240
Query: 4744 LKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGE 4803
G Q L++V + +E+L PL + Q+ G + + E
Sbjct: 2241 --------GKEQQLKEKLEQVKLLVEEL-----PLR-QGILKQLNETGGPVLVSAPISPE 2286
Query: 4804 TVTECESRMVQSIDFQTEMSRSLDWLR-RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEE 4862
+ E+++ Q+ ++SR+L + ++A++ L+ L+D++E++ + +
Sbjct: 2287 EQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSP 2346
Query: 4863 VQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQE---ALRTRQATLTE 4919
+++ L I N + E D+QE A++ +Q + E
Sbjct: 2347 IRNQLEIYNQPNQ-------------------------EGPFDVQETEIAVQAKQPDVEE 2381
Query: 4920 IYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTE-DQFHSNL 4978
I S+ Q Y+ + A + +K +E S+E + L
Sbjct: 2382 ILSKGQHLYKE------------------------KPATQPVKRKLEDLSSEWKAVNRLL 2417
Query: 4979 EELHSLVATLDPLIKPTGKEDLE------QKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5032
+EL + L P + G + Q V + E ++ S +++
Sbjct: 2418 QELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALA---- 2473
Query: 5033 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALE 5092
D+ +A E+ + ++ ++ + ++ + E + + KA + + ++ L
Sbjct: 2474 -DFNRAWTELTDWLSLLDQVIKSQRVM-VGDLEDINEMIIKQKATMQDLEQRRPQLEELI 2531
Query: 5093 EKASQLE-KTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKK 5151
A L+ KT N ++ ++ + + +W ++ Q++ + L + + + T + ++
Sbjct: 2532 TAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEE 2591
Query: 5152 ATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDG 5211
A +++ Q + KL + + + +L Q Q+ + + L +L+D
Sbjct: 2592 AEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDY 2651
Query: 5212 AAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQET 5271
+A ++ + IT E + + + + + + +RE ++ET
Sbjct: 2652 SA----DDTRKVHMIT----------ENINASWRSIHKRVSEREAA----------LEET 2687
Query: 5272 KEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5331
L + LE+ LTEA ++ +++ L E
Sbjct: 2688 HRLLQ----QFPLDLEKFLAWLTEAETTANVLQDATRKER-----------------LLE 2726
Query: 5332 VALDLK-IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
+ +K + Q QD E+E L QK+ + L + D
Sbjct: 2727 DSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL---------------EGSDD 2771
Query: 5391 QKVLGEELDGCNSKLMEL---DAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5447
+L LD N K EL ++ LE + K L + +L + Q +R
Sbjct: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELL-VWLQLKDDELSR 2830
Query: 5448 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKE 5507
+ + +++ N++ + ++ + + T+ + + L +E +E
Sbjct: 2831 QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRE 2890
Query: 5508 IDSELEA--MTEKLQYLTSVYCT--EKMSQQVAELGRETEELRQMIKIRLQNLQDAAK-- 5561
+ E A +T L+ T EK++ A+ R+ +E + RLQ LQ+A
Sbjct: 2891 LPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE----RLQELQEATDEL 2946
Query: 5562 DMKKFEAELKK-------------LQAALEQAQATLTSPEVGRLS-LKEQLSHRQHLLSE 5607
D+K +AE+ K LQ LE+ +A G ++ LKE +SH L +
Sbjct: 2947 DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALR-----GEIAPLKENVSHVNDLARQ 3001
Query: 5608 MESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTA 5655
+ +L +QL L ED+ L A+ E+ R H A
Sbjct: 3002 LTTL-----GIQLSPYNLSTLEDLNTRWKLLQVAV---EDRVRQLHEA 3041
Score = 157 bits (397), Expect = 4e-37
Identities = 502/2833 (17%), Positives = 1051/2833 (37%), Gaps = 427/2833 (15%)
Query: 5449 SKLNQAASHLEEYNEMLELILKWIEKAK--VLAHGTIAWNSASQLREQYILHQTLLEESK 5506
S L ++ +L+ Y LE +L W+ A+ + A G I+ N +++Q+ H+ +
Sbjct: 332 SSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEIS-NDVEVVKDQFHTHEGYM---M 387
Query: 5507 EIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKK- 5565
++ + + LQ + + T K+S+ E +E ++ R + L+ A+ + +
Sbjct: 388 DLTAHQGRVGNILQLGSKLIGTGKLSEDEET---EVQEQMNLLNSRWECLRVASMEKQSN 444
Query: 5566 FEAELKKLQ-AALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSA 5624
L LQ L++ LT E ++E+ L ++E LK +VQ ++ Q
Sbjct: 445 LHRVLMDLQNQKLKELNDWLTKTEERTRKMEEE-----PLGPDLEDLKRQVQQHKVLQED 499
Query: 5625 LRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIE 5684
L ++ V L H + + E + A+ E+++K L
Sbjct: 500 LE--QEQVRVNSLTHMVVVVDESSGDHATAAL----------------EEQLKVLGDRWA 541
Query: 5685 GAHREIEDKPVATSNI----QEL-------QAQISRHEELAQKIK--GYQEQIASLNSKC 5731
R ED+ V +I Q L A +S E+ KI G+++Q L+S
Sbjct: 542 NICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQ 601
Query: 5732 KMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------RCHTL 5785
K+ +KA ++ ++ L + +LL T + SV T RC
Sbjct: 602 KLAVLKADLEKKKQSMGKLYSLKQ-------DLLSTLK-NKSVTQKTEAWLDNFARCWDN 653
Query: 5786 LSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHP 5845
L E+S ++IS PS T + + + + Q + P
Sbjct: 654 LVQKLEKS-----TAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPP-PP 707
Query: 5846 STSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSIS 5905
Q + + + +L SW T + + + ++ + D +
Sbjct: 708 PQKKRQITVDSEIRKRLDVDITELH-SWITRSEAVLQSPE--FAIFRKEGNFSD----LK 760
Query: 5906 TKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEAD 5965
K+ AIE + +E + LQD Q+ L E++V+E AD
Sbjct: 761 EKVNAIEREKAE--------------------KFRKLQDASRSAQA-LVEQMVNEGVNAD 799
Query: 5966 PAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELD 6025
+Q + Q + + QLL E+LN LE Q A + +L+
Sbjct: 800 SIKQASEQ------------LNSRWIEFCQLLSERLN-WLEYQNNIIAFYN---QLQQLE 843
Query: 6026 SWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKA 6085
+ + L + P EP +++QL C++ + + + L + + L +G+
Sbjct: 844 QMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQG 903
Query: 6086 HTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWL 6145
+A+ +A H KQ+ A+EKE + T P +
Sbjct: 904 PMFLDADFVAF--------------TNHFKQVFSDVQAREKELQTI--FDTLPPMRYQET 947
Query: 6146 AQARTTWTQQRQSSLQ-------QQKELEQELAEQKSLLRSVASRGEEIL-----IQHSA 6193
A TW QQ ++ L + +EQ L E ++L S+ + + ++ +
Sbjct: 948 MSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1007
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSA---------EDQM-------------------- 6224
+ + K +E+ +K S+ E+QM
Sbjct: 1008 KKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEV 1067
Query: 6225 ----RMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAV 6280
+ +W +L K++L Q L Q + N + G K + + S +
Sbjct: 1068 DVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRL 1127
Query: 6281 TSLLDGLNQAFEEVSSQSGGAK---RQSIHLEQKLYDGVSATSTWLDDVEERLFVATA-- 6335
+ L LN ++ + Q K + + L +S W+ EE
Sbjct: 1128 ETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEY 1187
Query: 6336 LLPEETETCLFNQEILAKDIKEMSEEM----DKNKNLFSQAFPENGDNRDVIEDTLGCLL 6391
P+E + + + ++ ++ ++ + ++ +QA P ++ ++ L L
Sbjct: 1188 KTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVA---QEALKKELETLT 1244
Query: 6392 GRLSLLDSVVNQRC----------HQMKERLQQILNFQNDLKVLFTSL------ADNKYI 6435
L + +N +C H++ L++ + N+++ + A+
Sbjct: 1245 TNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISE 1304
Query: 6436 ILQKLANVFE--QPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQ 6493
+L L N+ + QI + Q D G+++ + +EL
Sbjct: 1305 VLDSLENLMRHSEDNPNQIRILAQTLT-----DGGVMD-----------ELINEELETFN 1348
Query: 6494 DMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQ 6553
+ EL R+ L Q++ + E++L + + L +++A ++ K +
Sbjct: 1349 SRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAA----YIADKVDAA 1404
Query: 6554 QLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVEL 6613
Q+ + ++ L SH I E + + + + +++Q K+ ++
Sbjct: 1405 QMPQEAQKIQSDLTSHEISLEEMKKH------NQGKEAAQRVLSQIDVAQKKLQDVSMKF 1458
Query: 6614 EYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQP 6673
+ + ++ ++ QE L+ V+ +P++ ++ + ++ +L SL+E +
Sbjct: 1459 R-LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKS 1517
Query: 6674 KLYQVLDDGKRLLISISCS---DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQ 6730
++ V+ G++++ +L+ ++ L + K+++ +LE LK + +
Sbjct: 1518 EVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMR 1577
Query: 6731 SESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSK----EVDAQSSLKS 6786
E L WL + T +T +E + +L++ + + K E++ Q
Sbjct: 1578 KEMNVLTEWLAA--------TDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLK 1629
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
S+ G L + + +LS ++S W + + L + Q +
Sbjct: 1630 SITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVD 1689
Query: 6847 EVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQI 6906
+ WI + ++ + E K + K K ++N + VD +
Sbjct: 1690 HITKWIIQADTLLDESEK--------KKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANL 1741
Query: 6907 SSQDVESKRSDKTDFAEQLGAMNKSWQILQGLV-TEKIQLLEGLLESWSEYENNVQCLKT 6965
+ + R Q+ +N + + + T K + L+ ++ +++Q L
Sbjct: 1742 MANRGDHCRKL---VEPQISELNHRFAAISHRIKTGKASIP---LKELEQFNSDIQKLLE 1795
Query: 6966 WFETQ--------EKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVE-KIEQNGLA 7016
E + E+ + ++ +V+ L+ +L+ I + K E KI+Q L
Sbjct: 1796 PLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQ 1855
Query: 7017 LIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDK-----I 7071
N +D+ S E+ W L L + + +S D+ I
Sbjct: 1856 TKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEI 1915
Query: 7072 NSYLMEARYSLSRFRLLTGSLE----AVQVQVDNLQNLQDDLEKQERSLQ-KFGSITNQL 7126
+ L + + L+ R L A+ V+ +Q L K+ R ++ KF
Sbjct: 1916 DRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ-----LSKRWREIESKFAQFRRLN 1970
Query: 7127 LKECHPPVTETLTNTLKEVNMRWNNLLEE-IAEQLQSSKALLQLWQRYKDYSKQCASTVQ 7185
+ H ET+ +++ + + + + E S+ALL++ Q
Sbjct: 1971 FAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN----------- 2019
Query: 7186 QQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDA 7245
A D A +D + L +KDSL + + + A
Sbjct: 2020 ------------------APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTA 2061
Query: 7246 SAASAIQSDQLSLSQHLCALEQALCK-------QQTSLQAGVLDYETFAKSLEALEAWIV 7298
+ SA +++ L + L L+ K +Q V + F ++ W+
Sbjct: 2062 ALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLT 2121
Query: 7299 EAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNE-LGYRLPLNDKEI- 7356
EAE+ L+ + + + + ++EL+ + + ++ L+ E + + D I
Sbjct: 2122 EAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASIL 2181
Query: 7357 -KRMQNLNRHWSLISSQTTERFSKLQ---SFLLQHQTFLEKCETWMEFLVQTEQKLAVEI 7412
+++ +LN W + Q ++R +L+ + L + Q L + W+E + + ++ +
Sbjct: 2182 QEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLE---EADNIASIPL 2238
Query: 7413 S-GNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQV--DDRDEFNLKLTLL 7469
G Q L E+ +L E+ RQ IL + G +L + +++D+ KL
Sbjct: 2239 EPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQT 2298
Query: 7470 SNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQA 7529
+ QW V R +++G I++QI+ + + E L + L + + I Q
Sbjct: 2299 NLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPN 2358
Query: 7530 RTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMR 7589
+ +VQ E +Q + G+ L + A ++ +L ++ +WK+ +
Sbjct: 2359 QEGPFDVQETEIAVQAKQPDVEEILSKGQHLY--KEKPATQPVKRKLEDLSSEWKAVNRL 2416
Query: 7590 LEEQKKKLAFL--------------------------------------------LKDWE 7605
L+E + K L L D+
Sbjct: 2417 LQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFN 2476
Query: 7606 KCEKGIADSLEKLRTFKKK---LSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSL 7662
+ + D L L K + L D +E + ++ ++LE + +T
Sbjct: 2477 RAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQN 2536
Query: 7663 LKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELC 7722
LK+ S + + +I+ +R+E +Q QW+E+ L RRQQ+ E L + + E +E
Sbjct: 2537 LKNKTS---NQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAE 2593
Query: 7723 EWLTQMESKVS--QNGDILIEEMIEKL--KKDYQEEIAIAQENKIQLQQMGERLAKASHE 7778
+ L Q +K+ + G ++ + +K+ K +++ Q N + +L +
Sbjct: 2594 QVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSA 2653
Query: 7779 SKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELA 7838
++ +N W+ + ++ R L+ET +QQ ++ WL E+E
Sbjct: 2654 DDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLT--EAETT 2711
Query: 7839 KPIVYDSCNSEE-------IQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACAT 7891
++ D+ E ++ + + Q+LQ +IE H+ ++ + +L + +
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEG-SD 2770
Query: 7892 DAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTA 7951
DA +Q+ N++ +W + S+ R +E + W++ WL+ +
Sbjct: 2771 DAVL--LQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL 2828
Query: 7952 AFPSSSGVIYTVAKEELKKFEAFQRQV-------------------HECLTQLELINKQY 7992
+ + G + +++ AF+R++ + L LE + ++
Sbjct: 2829 SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEP 2888
Query: 7993 RRLARENRTDSACS-LKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILV 8051
R L E R + L++ E N W+ L R++ + + +E + A D
Sbjct: 2889 RELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATD---- 2944
Query: 8052 WLTEMDLQLTNIE 8064
E+DL+L E
Sbjct: 2945 ---ELDLKLRQAE 2954
Score = 135 bits (341), Expect = 1e-30
Identities = 421/2275 (18%), Positives = 879/2275 (38%), Gaps = 333/2275 (14%)
Query: 3663 QATQLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK 3722
Q L SR++ L + +E+ L + L+ + L +DW T + + + +
Sbjct: 423 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK--LKELNDWLTKTEERTRKMEEEPLG 480
Query: 3723 VDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQL 3782
D + ++++ +VL +D+E+ + S V ++E + + + ++ L
Sbjct: 481 PDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHM----VVVVDESSGDHATAALEEQLKVL 536
Query: 3783 KELTSTVRK----EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK 3838
+ + + + + L+ L + +++ + W++E ++ ++ K+ K
Sbjct: 537 GDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVN-----KIHTTGFK 591
Query: 3839 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDV--TLKDKIDQLQSDYQDLCSIGK 3896
Q SLQ+ + K + G+ L L QD+ TLK+K +++
Sbjct: 592 DQNEMLSSLQKLAVLKADLEKKKQSMGK-LYSLKQDLLSTLKNKSVTQKTE--------- 641
Query: 3897 AMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRM 3956
A ++ A D L K I Q Q L Q ++ + + + Q +
Sbjct: 642 AWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTT------VMETVTTVTTREQIL 695
Query: 3957 YQSLEHELQK---HVSRQDTLQ------------QCQAWLSAVQPDLEPSPQPPLSRAE- 4000
+ + EL RQ T+ + +W++ + L+ SP+ + R E
Sbjct: 696 VKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQ-SPEFAIFRKEG 754
Query: 4001 ----------AIKQVK--HFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIE 4048
AI++ K FR LQ+ +R+ L+ M + A I+Q + +
Sbjct: 755 NFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEG-----VNADSIKQASEQLN 809
Query: 4049 QKLVQAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMK-----RRHSELELNIAQNM 4100
+ ++ L W E ++ + LQ +Q + + + E ++
Sbjct: 810 SRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQ 869
Query: 4101 VSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI------NHLNDQWLDLCRQS 4154
+ KD V +L Q + + + L +K + P + NH + D+ Q+
Sbjct: 870 LKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDV--QA 927
Query: 4155 NNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWD--NLARSDAESTAVHLEALKKLAL 4212
LQ D Y + M+ + ++++ T+ L+ +D E L L+ L
Sbjct: 928 REKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQS 987
Query: 4213 ALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNL 4272
+LQE++ + L ++M + + + + +E RW +L + Q +
Sbjct: 988 SLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQM 1047
Query: 4273 EELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKS 4332
+L +Q+ Q L +W E + E ++ + L + S+++ Q L S
Sbjct: 1048 NKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNS 1107
Query: 4333 LIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVF 4392
+ + ++ + ++ L + + + + V R++ L L + +
Sbjct: 1108 VNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLS 1167
Query: 4393 QATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSA-------QASLKTYQNEVTGLWAQ 4445
+ + Q E + + R+ PD++ K V+ K A +A +K V + AQ
Sbjct: 1168 EMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQ 1227
Query: 4446 GRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACH 4505
+ +E ++E L+ L + Y + + + + + LE+ +KA
Sbjct: 1228 APPVAQEALKKE-------LETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANK 1280
Query: 4506 WLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEV 4565
WL + + N+ + E+ L +N++ S + N + L +T
Sbjct: 1281 WLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQT---------LT 1331
Query: 4566 DHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLR 4625
D + E +N FN ++ ++ E + R++ L+E + QS E E
Sbjct: 1332 DGGVMDELINEELETFN-------SRWRELHEEAVRRQK---LLEQSIQSAQETEKSL-- 1379
Query: 4626 MSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLV 4685
++E+L+ D A A + + VD +E Q Q D H +
Sbjct: 1380 -------HLIQESLTFIDKQLA-----AYIADKVDAAQMPQE-----AQKIQSDLTSHEI 1422
Query: 4686 TLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK 4745
+L ++H + + +R L + Q K+ + ++ K +
Sbjct: 1423 SL-------------------EEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSM----KFR 1459
Query: 4746 MYHSLAG---SLQDSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIG 4802
++ A LQ+S ++L V +HL P L+ + E + +QS L ++
Sbjct: 1460 LFQKPANFEQRLQESKMILDEVKMHL----PALETKSVE--QEVVQSQLNHCVNLYKSLS 1513
Query: 4803 ETVTECE------SRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKI 4856
E +E E ++VQ QTE + LD RV A L L+ ++ K+
Sbjct: 1514 EVKSEVEMVIKTGRQIVQK--KQTENPKELD--ERVTA-------LKLHYNELG---AKV 1559
Query: 4857 QIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDG---DIQEALRTR 4913
+++++ L++ + KE + L + D+E L + S ++G ++ +
Sbjct: 1560 TERKQQLEKCLKLSRKM---RKEMNVLTEWLAATDME--LTKRSAVEGMPSNLDSEVAWG 1614
Query: 4914 QATLTEIYSQ---CQRYYQVFQAANDWLEDAQELLQ-----LAGNGLDVES-AEENLKSH 4964
+AT EI Q + +V +A L + L++ L N + V S AEE L
Sbjct: 1615 KATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLL 1674
Query: 4965 MEFFSTEDQFHSNLEELHSLVATLDPLI------KPTGKEDLEQKVASLELRSQRMSRDS 5018
+E+ + F N++ + + D L+ KP KED+ +++ + EL R DS
Sbjct: 1675 LEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKA-ELNDIRPKVDS 1733
Query: 5019 GAQVDLLQRCTAQWHDY-QKAREEVIELMNDTEKKLSEFSLLKTSSS----HEAEEKLSE 5073
D A D+ +K E I +N +S +KT + E E+ S+
Sbjct: 1734 TR--DQAANLMANRGDHCRKLVEPQISELNHRFAAISH--RIKTGKASIPLKELEQFNSD 1789
Query: 5074 HKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSM---TTVWQRWT--RLRAVA 5128
+ L+ + + ++ V L+E+ K N+ ++ T+ + + QR T R R
Sbjct: 1790 IQKLLEPLEAEIQQGVNLKEE--DFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEI 1847
Query: 5129 QDQEKILE------------------DAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEK 5170
+ ++++L+ + +W + + + +D ++ KL S E
Sbjct: 1848 KIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL-ASLPEP 1906
Query: 5171 ASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAA----PTPGEEPPLMQEI 5226
+ ++ + EL++++ L +R+Q + +DGAA PT + +EI
Sbjct: 1907 RDERKIKEIDR-------ELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREI 1959
Query: 5227 TA--MQDRCLNMQE--KVKTNGKLVKQELKDREM------VETQINSVKCWVQETKEYLG 5276
+ Q R LN + V+ +V E E+ T+I V + E ++ L
Sbjct: 1960 ESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLN 2019
Query: 5277 NPTI---EIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSE-LSLQLAEV 5332
P + + + ++ + L + +Q+ ++ +K L + P E + LQ A
Sbjct: 2020 APDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALS 2079
Query: 5333 ALDL---KIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKT---DNVVQ 5386
LD K+ +D+ ++S + I K+ T + KT +N
Sbjct: 2080 QLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDI-KIFNQWLTEAEQFLRKTQIPENWEH 2138
Query: 5387 AKTDQKVLGEELDGCNSK---LMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTIR 5442
AK + L E DG + + L+A ++ ++Q+ + L +K+G L Q+ +
Sbjct: 2139 AKY-KWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCK 2197
Query: 5443 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5502
Q +R +L + + L E+ L + W+E+A +A + QL+E+ + L+
Sbjct: 2198 QLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLV 2257
Query: 5503 EESKEIDSELEAMTEK-----LQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQ 5557
EE L+ + E + S +K+ ++ + + ++ + + + ++
Sbjct: 2258 EELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIE 2317
Query: 5558 DAAKDMKKFEAELKKLQAALE-------------------------QAQATLTSPEVGRL 5592
KD+ + E +L+ L+ L Q T + + +
Sbjct: 2318 AQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQETEIAVQAKQP 2377
Query: 5593 SLKEQLSHRQHLLSE----------MESLKPKVQAVQLCQSALRIPE-DVVASLPLCHAA 5641
++E LS QHL E +E L + +AV LR + D+ L A+
Sbjct: 2378 DVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGAS 2437
Query: 5642 ----LRLQEEASRLQHTAIQQCNIMQAAVVQ---YEQYEQEMKHLQQLIEGAHREIEDKP 5694
+ L + + TAI + + + +++ + + L + + I+ +
Sbjct: 2438 PTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQR 2497
Query: 5695 VATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTE 5749
V +++++ I + + Q ++ + Q+ L + + L K + +T+
Sbjct: 2498 VMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITD 2552
Score = 129 bits (323), Expect = 2e-28
Identities = 269/1454 (18%), Positives = 572/1454 (39%), Gaps = 260/1454 (17%)
Query: 7259 SQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTI 7318
SQHL A E +SL ++ + + +LE + +W++ AE+ LQ Q S+D+ +
Sbjct: 319 SQHLEAPEDK--SFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEI-SNDVEVV 375
Query: 7319 QERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDK-------EIKRMQNL-NRHWSLIS 7370
+++ +G M+ ++ + + +LG +L K E++ NL N W +
Sbjct: 376 KDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLR 435
Query: 7371 SQTTERFSKLQSFLLQHQTF-LEKCETWMEFLVQTEQKLAVEISG-NYQHLLEQQRAHEL 7428
+ E+ S L L+ Q L++ W+ + +K+ E G + + L Q + H++
Sbjct: 436 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKV 495
Query: 7429 FQAEMFSRQ----QILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7484
Q ++ Q + H +++ + + ++ L +L ++W + R + R
Sbjct: 496 LQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQ----LKVLGDRWANICRWTEDRW 551
Query: 7485 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7544
++ + +WQR E WL E D V
Sbjct: 552 VLLQDILLKWQRLTEEQCLFSAWLSEKE---------------------DAVNKIHTTGF 590
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
+ Q + +++ K +L AD + +L +++ S +++ + +K L ++
Sbjct: 591 KDQNEMLSSLQ--KLAVLKADLEKKKQSMGKLYSLKQDLLS-TLKNKSVTQKTEAWLDNF 647
Query: 7605 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7664
+C + LEK ++ AV + LTQ +++
Sbjct: 648 ARCWDNLVQKLEK------------------------STAQISQAVTTTQPSLTQTTVM- 682
Query: 7665 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7724
+T++ + + I L++ EEL +++QI V SE K L
Sbjct: 683 ETVTTVTTREQI--------LVKHAQEELPPPPPQKKRQI-------TVDSEIRKRLDVD 727
Query: 7725 LTQMESKVSQNGDILIEEMIEKLKK-----DYQEEI-AIAQE--NKIQLQQMGERLAKAS 7776
+T++ S ++++ +L +K D +E++ AI +E K + Q R A+A
Sbjct: 728 ITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQAL 787
Query: 7777 HESKASE------IEYKLGKVNDRWQHLLDLIAARVKKL--KETLVA----VQQLDKNMS 7824
E +E I+ ++N RW L++ R+ L + ++A +QQL++ +
Sbjct: 788 VEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTT 847
Query: 7825 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7884
+ WL + ++P S + + ++N LQ IE+ L + + L
Sbjct: 848 TAENWLKIQPTTPSEPTAIKS-QLKICKDEVNRLSGLQPQIER--------LKIQSIALK 898
Query: 7885 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL 7944
+ + D + T + + + ++ A E + + + ++ + S W+
Sbjct: 899 EKGQGPMFLDADFV-AFTNHFKQVFSDVQAREKELQTIFDTLPPM--RYQETMSAIRTWV 955
Query: 7945 KSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSA 8004
+ SE + P S Y + ++ L + +A Q + E + L ++ + ++++ ++ +
Sbjct: 956 QQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEIS 1015
Query: 8005 CSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQL-TNI 8063
+ E RW L ++ ++L+ + + + + ++ W+ E+D+ L
Sbjct: 1016 RKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEW 1075
Query: 8064 EHFSECDVQAK-IKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELR 8122
+ ++ K +KQ + +I + + G+++ ++EP A+ +E EL EL
Sbjct: 1076 PALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELN 1135
Query: 8123 ----RYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLH-WHDRSADSL 8177
CQ+V+ R E L ++ + L+ LS++H W ++ +
Sbjct: 1136 TQWDHMCQQVYARKEALKGGL-------------EKTVSLQKD--LSEMHEWMTQAEEEY 1180
Query: 8178 LSPQPSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDE 8237
LE D +Y +L+ A+ +++E
Sbjct: 1181 ----------------------------------LERDFEYKTPDELQKAVEEMKRAKEE 1206
Query: 8238 EGQDDKDFYLRGAVGLSDVMI---PESPEAYVKLTENAIKN-------TSGDHSALE--- 8284
Q + L ++ V+ P + EA K E N +G LE
Sbjct: 1207 AQQKEAKVKLL-TESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVW 1265
Query: 8285 -------SQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSID 8337
S + + K L++ F+++ TENI P G E E S +D
Sbjct: 1266 ACWHELLSYLEKANKWLNEVEFKLKTTENI-----PGGAE-------------EISEVLD 1307
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID------------RWELLQAQALSKEL 8385
S LE+ ++ E++ P + + + GV+D RW L +A+ ++
Sbjct: 1308 S---LENLMRHSEDN-PNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQK 1363
Query: 8386 RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD 8445
++Q++Q Q +TE+ L +Q D Q K+ Q +
Sbjct: 1364 LLEQSIQSAQ--------------ETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQE 1409
Query: 8446 HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8505
+K + +L S E + + K+ +Q RV S ++ + LQD M+ +
Sbjct: 1410 AQK---IQSDLTSHEISLEEMKKH-------NQGKEAAQRVLSQIDVAQKKLQDVSMKFR 1459
Query: 8506 GFHEMSHGLLLMLEN---IDRRKNEIVPIDS-NLDAEILQDHHKQLMQIKHELLESQLRV 8561
F + ++ + E+ +D K + +++ +++ E++Q + + L E + V
Sbjct: 1460 LFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEV 1519
Query: 8562 ASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQD- 8620
+ Q++ + + E E+V + L +V+ ++LEK L +S +
Sbjct: 1520 EMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKE 1579
Query: 8621 ---LSSWSSADELD 8631
L+ W +A +++
Sbjct: 1580 MNVLTEWLAATDME 1593
Score = 119 bits (298), Expect = 1e-25
Identities = 407/2222 (18%), Positives = 875/2222 (39%), Gaps = 318/2222 (14%)
Query: 528 SKLKSWIIKYGRRESVEQLLQNYVSFIEN---------SKFFEQYEVTYQILKQTAEMYV 578
S +++W+ + + S+ QL +E S EQ Y + EM
Sbjct: 949 SAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSK 1008
Query: 579 KADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLED 638
KA + + E +W+ LS ++ LEE ++ + N + +L+ W+ +
Sbjct: 1009 KAPSEI--SRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
Query: 639 AEKMLNQ-------SENAKKDF--FRNLPHWIQ----QHTAMNDAGNFLIETCDEMVSRD 685
+ L + SE KK R L IQ ++N+ G + + +
Sbjct: 1067 VDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASR 1126
Query: 686 LKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLS----EP 741
L+ +L LN +W + +V YA+ + + K + V+L +E H+ ++ E
Sbjct: 1127 LETELKELNTQWDHMCQQV--YARKEAL----KGGLEKTVSLQKDLSEMHEWMTQAEEEY 1180
Query: 742 LEVSFM-----NVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATM 796
LE F ++ +++++ ++ +A+ K++T++ + + ++P
Sbjct: 1181 LERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPP-------VAQ 1233
Query: 797 SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSA 856
LK++L + Y L LEE+ L K N+ + +E
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVE------- 1286
Query: 857 LFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV-TLSNVLKHFDQTRLQRQIADIHVAF 915
FK K T I G++ + + + +L N+++H + Q +I +
Sbjct: 1287 -FKLK-------------TTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTD 1332
Query: 916 QSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFS 975
++ + + + +ET + ++ E +K+L ++ ++ + E+ L E +
Sbjct: 1333 GGVMDELIN--EELETFNSRWRELHEEAVRRQKLL---EQSIQSAQETEKSLHLIQESLT 1387
Query: 976 QLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRK----LHKQWKDLQGEAPYHLLHLKI 1031
+D++ L A++ D++ QE Q +Q + L + K QG+ + +I
Sbjct: 1388 FIDKQ-LAAYI--ADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQI 1444
Query: 1032 DVEKNRFLASVEECRTELDRETKLMPQEGS-EKIIKEHRVFFSDKGPHHLCEKRLQLIEE 1090
DV + + ++ + +L + + E+ ++E ++ D+ HL + +E+
Sbjct: 1445 DVAQKKL--------QDVSMKFRLFQKPANFEQRLQESKMIL-DEVKMHLPALETKSVEQ 1495
Query: 1091 LCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYR--------KLMEDPDKWKDYTS---- 1138
V+ + V + +L E+++ ++ + K E+P + + +
Sbjct: 1496 EVVQSQLNHCVN-----LYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKL 1550
Query: 1139 RFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNG---VTKRGETLSWLKSRL 1195
++E + ++ + QL+ K + E+ E + +TKR + + S L
Sbjct: 1551 HYNELGAKVTERKQQLE--KCLKLSRKMRKEMNVLTEWLAATDMELTKRS-AVEGMPSNL 1607
Query: 1196 --KVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEI-VKNSL 1252
+V +++ E +KQ L ++ +AL T+L + E ++ + + I V +
Sbjct: 1608 DSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRA 1667
Query: 1253 EELISGSKEVQEQAEKILD-----TENLFEAQQLLLHHQQKT--------KRISAKKRDV 1299
EE ++ E Q+ E T+ + +A LL ++K KR+ A+ D+
Sbjct: 1668 EEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDI 1727
Query: 1300 QQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETV 1359
+ ++ + L + RKL + E R ++ R +T K ++
Sbjct: 1728 RPKVDSTRDQAANLMANRGDHCRKLVEP-----QISELNHRFAAIS----HRIKTGKASI 1778
Query: 1360 -VRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQ 1418
++ L Q S ++ L E L +E++Q + + + +N + G
Sbjct: 1779 PLKELEQFNSDIQKLL-----EPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDN 1833
Query: 1419 NKQLLQQQAK----SIKEQVKKLEDTLEEDIKTMEMVKT-----KWDHFGSNFETLSVWI 1469
+Q + + K IK+Q+ + + +D+++ K +W + + L +
Sbjct: 1834 LQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCL 1893
Query: 1470 TEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSI----VGLEEEAQSFA----QFV 1521
+ EK+L +L + +I +I +Q+ + +L+++ GL E+ + A Q
Sbjct: 1894 DDIEKKLASLPEPRD--ERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQ 1951
Query: 1522 TTGESARIKAKLTQIRRYG----EELREHAQCL--EGTILGHLSQQQKFEENLRKIQQSV 1575
+ I++K Q RR +RE + E L + + + Q++
Sbjct: 1952 LSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQAL 2011
Query: 1576 SEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI-------TAFSASARKVVN 1628
E E L P + +K + ++ +L+ S I TA SA V
Sbjct: 2012 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPV-E 2070
Query: 1629 RDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSP 1688
R + + L Q+E + + K+RQ + + W+R ++ F WL E
Sbjct: 2071 RVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKT 2130
Query: 1689 EMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQ 1748
++ + + K + L + LQ+ + + + L E + +SK D +++ L
Sbjct: 2131 QIPENWEHAKYKWYL---KELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGS 2187
Query: 1749 LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQV 1808
L+ RW+++ + ++ R L+ +F L F +W L E + I + +
Sbjct: 2188 LNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLW----LEEADNIASIPLEPGKE 2243
Query: 1809 ALTRHKDHAAEVESKKGELQSLQGHLAKLGSLG---------RAEDLHLLQGKAEDCFQL 1859
+ K+ +V+ EL QG L +L G E+ L+ K +
Sbjct: 2244 --QQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQ 2301
Query: 1860 FEEASQVVERRQLAL-SHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN- 1917
+ + S+ + +Q + + + + Q L + QL + + + +N+ ++ +
Sbjct: 2302 WIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPI-RNQLEIYNQPNQE 2360
Query: 1918 ---DALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLG 1974
D + A+++ ++ ILSK Q+ K + Q + + L E + + LL
Sbjct: 2361 GPFDVQETEIAVQAKQPDVEEILSKGQHLYKEKPATQ--PVKRKLEDLSSEWKAVNRLLQ 2418
Query: 1975 TKQSEADALAVLKKAFQDQKEELLKSIED--IEERTDKERLKEPTRQALQ-QRLRVFNQL 2031
+++ LA + + + + + T +L+ P+ L+ L FN+
Sbjct: 2419 ELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRA 2478
Query: 2032 EDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGL 2091
EL WL Q+ + +++ +IN + + T + + + + Q L
Sbjct: 2479 WTELTD------WL-SLLDQVIKSQRVMVGDLE-DINEMIIKQKATMQDLEQRRPQ---L 2527
Query: 2092 IDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDN 2151
+L+ QNLK+ S + A ++I R E +N+ + Q+ L N
Sbjct: 2528 EELITAAQNLKNKTSN--QEARTIITDRI---------------ERIQNQWDEVQEHLQN 2570
Query: 2152 FTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLS 2211
+ L+E+ K +ST +WL+ E+ E+ + + R L W +
Sbjct: 2571 ----RRQQLNEMLK-------------DST--QWLEAKEEAEQVLGQARAKLESWKEGPY 2611
Query: 2212 TRDEIEGWSNNCVPQMAENI----SNLD--NHLRAEELLKEFESEVKNKALRLEE----- 2260
T D I+ Q+A+++ +N+D N L A +LL+++ ++ K + E
Sbjct: 2612 TVDAIQKKITE-TKQLAKDLRQWQTNVDVANDL-ALKLLRDYSADDTRKVHMITENINAS 2669
Query: 2261 ---LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVE 2317
+H +V++ + + ET LQ DL + L E E L+D +T+ E
Sbjct: 2670 WRSIHKRVSEREAALE--ETHRLLQQFPLDLEKFLAWLTE-AETTANVLQD----ATRKE 2722
Query: 2318 KFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKY 2377
+ + D E +K+ +D+Q E+++ + EN + R
Sbjct: 2723 RLLED----------------SKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSL 2766
Query: 2378 H-SAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE--KHFSESMQEFQEWF----- 2429
S + L R + + K + + ++ L+ S + K S+QE W
Sbjct: 2767 EGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDD 2826
Query: 2430 -------LGA--KAAAKESSDRTGDSKVLEAKLHDLQNILDSV-----SDGQSKLDAVTQ 2475
+G A K++ + L+ K + + L++V L+ + Q
Sbjct: 2827 ELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2886
Query: 2476 EGQTLYAHLSKQIVSS-IQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
E + L Q V+ +++Q + N E++ ++ + + L ++ +L
Sbjct: 2887 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDEL 2946
Query: 2535 NLWIHEMEE-RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
+L + + E + + + +G+ I ++ + KV+ GE+ +E++ ++ + L+
Sbjct: 2947 DLKLRQAEVIKGSWQPVGDLL--IDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTT 3004
Query: 2594 EG 2595
G
Sbjct: 3005 LG 3006
Score = 102 bits (255), Expect = 1e-20
Identities = 351/2051 (17%), Positives = 783/2051 (38%), Gaps = 301/2051 (14%)
Query: 3824 LHVPEEPKM--ELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKI 3881
L PE+ L E + L +Y++ + VLS + S + +A E+ DV +
Sbjct: 322 LEAPEDKSFGSSLMESEVNLDRYQTALEEVLSW---LLSAEDTLQAQGEISNDVEV---- 374
Query: 3882 DQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQG 3941
+D + M ++ + R+ N+ G LIG KL ++ +Q
Sbjct: 375 ------VKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGT------GKLSEDEETEVQE 422
Query: 3942 TKDSYSA---ICSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSR 3998
+ ++ A QS H + + Q L++ WL+ + + PL
Sbjct: 423 QMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQK-LKELNDWLTKTEERTRKMEEEPLGP 481
Query: 3999 --AEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQN 4056
+ +QV+ + LQE DL +++ + D + Q +
Sbjct: 482 DLEDLKRQVQQHKVLQE------DLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKV 535
Query: 4057 LTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQ- 4115
L W I + W+ LQD + Q + E + +S+ +D V K+ +
Sbjct: 536 LGDRWANICRWTEDRWVLLQDILLKWQRLTE-----EQCLFSAWLSEKEDAVNKIHTTGF 590
Query: 4116 ASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCM 4175
N ++ + KL + E K +QS ++DL T
Sbjct: 591 KDQNEMLSSLQKLAVLKADLEKK-------------KQSMGKLYSLKQDLLSTLKNKSVT 637
Query: 4176 NVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKY--AIEDLKDQKQKMIE 4233
E +L+ F WDNL + +STA +A+ +L + + + ++Q +++
Sbjct: 638 QKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVK 697
Query: 4234 HLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
H +EL ++R ++ I++++ V +T EL W
Sbjct: 698 HAQ---EELPPPPPQ--KKRQITVDSEIRKRLDVDIT-------------ELHSWITR-- 737
Query: 4294 PNIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQ 4353
+EA+ QSP + + S+L+ K ++ + R + D + + +++
Sbjct: 738 ---SEAVLQSP-----EFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVE 789
Query: 4354 KALSDAQSHVNCLSDLVGQRRKYLN-------KALSEKTQFLMA---VFQATSQIQQHER 4403
+ +++ + +D + Q + LN + LSE+ +L + +Q+QQ E+
Sbjct: 790 QMVNEGVN-----ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQ 844
Query: 4404 KIMFREHICLL-------PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVT-- 4454
E+ + P + Q+K CK L Q ++ L Q L ++
Sbjct: 845 MTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSGLQPQIERLKIQSIALKEKGQGP 904
Query: 4455 --------------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF 4500
+Q S+V + +ELQ+++D++ ++E
Sbjct: 905 MFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTL----------------PPMRYQETM 948
Query: 4501 DKACHWLKQADI-VTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTIL 4559
W++Q++ ++ P++++ + + +L + Q + E ++ L L T + +
Sbjct: 949 SAIRTWVQQSETKLSIPQLSV-TDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMS 1007
Query: 4560 PSL-NEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSE 4618
+E+ Y SE + ++ + + + K++E + ++ + I+ + ++E
Sbjct: 1008 KKAPSEISRKYQSE-FEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAE 1066
Query: 4619 LEAQFLRMSKVPTDLAVEEALSLQ-DGCRAILDEVAGLGEAVDELNQKKEGFRSTGQP-- 4675
++ FL+ + P L E L Q CR ++ ++ + +++ +N+ + ++ +P
Sbjct: 1067 VDV-FLK-EEWPA-LGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEF 1123
Query: 4676 ------------WQPDKMLHLVTLYHR---LKRQTEQRVSLLEDTTSAYQEHEKMCQQLE 4720
Q D M V Y R LK E+ VSL +D + + HE M Q E
Sbjct: 1124 ASRLETELKELNTQWDHMCQQV--YARKEALKGGLEKTVSLQKDLS---EMHEWMTQAEE 1178
Query: 4721 RQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAY 4780
L+ ++ + K +E A E++K A Q +K +T + + P+A
Sbjct: 1179 EYLE--RDFEYKTPDELQKAVEEMKRAKEEA---QQKEAKVKLLTESVNSVIAQAPPVAQ 1233
Query: 4781 EKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPV 4840
E + ++++ + L + + E + + + ++ WL V+ +L
Sbjct: 1234 EALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTE 1293
Query: 4841 YLDLNLQDIQE---EIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLA 4897
+ ++I E + + H E+ + +RI L +L
Sbjct: 1294 NIPGGAEEISEVLDSLENLMRHSEDNPNQIRI----------------------LAQTLT 1331
Query: 4898 ELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDV--E 4955
+ +D I E L T + E++ + R ++ + + ++ ++ L L L +
Sbjct: 1332 DGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDK 1391
Query: 4956 SAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMS 5015
+ ++ + +L S +L+ + K ++ Q+V S +Q+
Sbjct: 1392 QLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKL 1451
Query: 5016 RDSGAQVDLLQRCTAQWHDYQKAR---EEVIELMNDTEKKLSEFSLLKTSSSH--EAEEK 5070
+D + L Q+ Q+++ +EV + E K E ++++ +H +
Sbjct: 1452 QDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKS 1511
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
LSE K+ V +V +IV ++ + E L +T + + L A +
Sbjct: 1512 LSEVKSEVEMVIKTGRQIVQKKQTENPKE----------LDERVTALKLHYNELGAKVTE 1561
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+++ LE + ++ TE + +L SA + + L + + + E+
Sbjct: 1562 RKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEI 1621
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE-ITAMQDRCLNMQEKVKTNGKLVKQ 5249
E+Q+ L ++++ + + G++ L+++ ++ + + + + + L+ +
Sbjct: 1622 EKQKVHL-----KSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLE 1676
Query: 5250 ELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEE-LQILLTEATNHRQNIEKMAE 5308
K E + ++ + W+ + L + Q E+ L+ L E + R ++ +
Sbjct: 1677 YQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRD 1736
Query: 5309 EQKEKYLG-------LYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSR 5361
+ L SEL+ + A ++ +K + +KE+EQ +
Sbjct: 1737 QAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKT-GKASIPLKELEQFNS------- 1788
Query: 5362 QIQKLAKDLTTILTKLKAKTDNVVQAKTDQ--KVLGEELDGCNSKLMELDAAVQKFLEQN 5419
D+ +L L+A+ V K + K + E+ +G +L++ +Q+ +
Sbjct: 1789 -------DIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDE 1841
Query: 5420 GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHL-EEYNEMLELILKWIEKA-KV 5477
+ + K+ +L + ++ ++ K SH +Y + +LK ++ K
Sbjct: 1842 RKREEIKIKQ--QLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKK 1899
Query: 5478 LAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLT----------SVYC 5527
LA S + R++ + KEID EL+ E+L + +
Sbjct: 1900 LA-------SLPEPRDE--------RKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMA 1944
Query: 5528 TEKMSQQVAELGRETEE---------LRQMIKIRLQNLQDAAKDM--------KKFEAEL 5570
E Q+++ RE E Q+ +R + + +DM + E+
Sbjct: 1945 VEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEI 2004
Query: 5571 KKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKP---KVQAVQLCQSALRI 5627
+ AL + + L +P++ ++ + L + +SL+ ++ + ++A
Sbjct: 2005 THVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQ 2064
Query: 5628 PEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAH 5687
V + L A +L + ++ + +V ++ ++ ++K Q + A
Sbjct: 2065 SATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAE 2124
Query: 5688 REIEDKPVATS--------NIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAK 5739
+ + + + ++ELQ I + + + + + E+I +SK ++ K
Sbjct: 2125 QFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEK 2184
Query: 5740 HATMLLTVTEV 5750
++ L EV
Sbjct: 2185 LGSLNLRWQEV 2195
Score = 49.3 bits (116), Expect = 2e-04
Identities = 143/807 (17%), Positives = 297/807 (36%), Gaps = 150/807 (18%)
Query: 141 QIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAG 200
Q++ L LP Q + + V P P ++ K++ K+ L+W++ +
Sbjct: 2252 QVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQD---KLENKLKQTNLQWIKVSRA 2308
Query: 201 ---KQTGIE--VKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAET 255
KQ IE +KD G+ + ++ + L + N+ N E F + ET
Sbjct: 2309 LPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVQET 2368
Query: 256 ELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYP-------DIHNASTDGQEDDEIL-- 306
E+ V +PD + I++ K P + + S++ + + +L
Sbjct: 2369 EIA---------VQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQE 2419
Query: 307 ---------PGFPSFANS--------VQNFKREDRVIFK--------------------- 328
PG + S Q ++ I K
Sbjct: 2420 LRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAW 2479
Query: 329 -EMKVWIEQFERDLTRAQMVESNLQDKYQSF---KHFRVQYEMKRKQIEHLIQPLHR-DG 383
E+ W+ ++ + +++ +L+D + K E +R Q+E LI
Sbjct: 2480 TELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKN 2539
Query: 384 KLSLDQAL---------VKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVA--- 431
K S +A ++ WD V L + QL++ L WL E A
Sbjct: 2540 KTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDST----QWLEAKEEAEQV 2595
Query: 432 ---LREEITVQQVHEETANTIQRKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQ 488
R ++ + T + IQ+K+ + K L ++ R + + + + D
Sbjct: 2596 LGQARAKLESWKEGPYTVDAIQKKITETKQLAKDL----RQWQTNVDVANDLALKLLRDY 2651
Query: 489 LEDMAERFHFVS-----STSELHLMKME---FLELKYRLLSLLVLAESKLKSWIIKYGRR 540
D + H ++ S +H E LE +RLL L K +W+ +
Sbjct: 2652 SADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETT 2711
Query: 541 ESVEQLLQNYVSFIENSKF--------------FEQYEVTYQILKQTAEMYVKADGSVEE 586
+V Q +E+SK E + Y L + ++ +++ ++
Sbjct: 2712 ANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDD 2771
Query: 587 AENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQS 646
A + + ++ +W L + ++RS LE W R ++ L WL+ + L++
Sbjct: 2772 AVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQ 2831
Query: 647 ENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGR----WRELFM 702
DF +Q+ ++ A ++T + ++ L+ + L + +L+
Sbjct: 2832 APIGGDF-----PAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ 2886
Query: 703 EVKQY---AQADEMDRMKKEYTDCVVT----LSAFATEAHKKLSEPLEVSFMNVKLLIQD 755
E ++ +A + R+ ++ + V T L+ + + +K+ E LE +Q+
Sbjct: 2887 EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLE--------RLQE 2938
Query: 756 LEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYSPLLY 815
L++ + + Q ++I K S Q G + ++ E++ ++ +PL
Sbjct: 2939 LQEATDELDLKLRQAEVI--------KGSWQPVGDLLIDSLQDHLEKVKALRGEIAPL-- 2988
Query: 816 ESQQLLIPLEELEKQMTSFYDSLGKIN 842
++ + + +L +Q+T+ L N
Sbjct: 2989 --KENVSHVNDLARQLTTLGIQLSPYN 3013
Score = 35.4 bits (80), Expect = 2.5
Identities = 32/140 (22%), Positives = 60/140 (42%), Gaps = 9/140 (6%)
Query: 5868 DLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES 5927
++ WE L ++ QR + E LER Q+ Q++ + K+ E+ G
Sbjct: 2910 EVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLID 2969
Query: 5928 QMAEH----QALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERM 5983
+ +H +AL EI L++ ++ + + LA +L + + P STL L R
Sbjct: 2970 SLQDHLEKVKALRGEIAPLKENVSHV-NDLARQLTTLGIQLSPYN----LSTLEDLNTRW 3024
Query: 5984 STIRMKASGKRQLLEEKLND 6003
+++ + + L E D
Sbjct: 3025 KLLQVAVEDRVRQLHEAHRD 3044
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 290 bits (742), Expect = 4e-77
Identities = 597/3145 (18%), Positives = 1243/3145 (39%), Gaps = 530/3145 (16%)
Query: 13 DIANVMQRLQDEQEIVQKRTFTKWINSHLAKR-KPPMVVDDLFEDMKDGVKLLALLEVLS 71
+ +++++ DE VQK+TFTKWIN+ +K KPP ++D+F D+KDG KLL LLE L+
Sbjct: 17 EFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPP--INDMFTDLKDGRKLLDLLEGLT 74
Query: 72 GQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLG 131
G LP E+G R+HA+ N+ L+ L H+ + ++LVNI TDI DG + LG
Sbjct: 75 GTSLPKERGST--RVHALNNVNRVLQVL------HQNN-VELVNIGGTDIVDGNHKLTLG 125
Query: 132 LMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKAL 191
L+W+IIL++Q++++ ++ ++ Q N++K L
Sbjct: 126 LLWSIILHWQVKDVMKDV-----------------------------MSDLQQTNSEKIL 156
Query: 192 LKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFT 251
L WV+ T + + V +F SW G+AF++V+H +P+L + V S E LE AF+
Sbjct: 157 LSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFS 216
Query: 252 IAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPD-------------------- 291
A+T LGI +LLDPEDV V PD+KSI+ Y+ + P
Sbjct: 217 KAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKE 276
Query: 292 -----IHNASTDGQEDDEI-LPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQ 345
I+ ST +E+ E PS V ++ +E+ W+ E
Sbjct: 277 CEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQD 336
Query: 346 MVESNLQ---DKYQSFKHFRVQYEMKRKQIEHLIQ---PLHRDGKLSLD----------- 388
+ +++ D++ + + F ++ + + ++Q L G LS +
Sbjct: 337 DISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTL 396
Query: 389 -----QALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHE 443
+AL +S DR SRL D ++L K L + AWL E +++ T +
Sbjct: 397 LNARWEALRVESMDR-QSRLHDVLMELQKK---QLQQLSAWLTLTEERIQKMETCPL--D 450
Query: 444 ETANTIQRKLEQHKDLLQNTDAHKRAFHE-------IYRTRSVNGIPVPPDQLEDMAERF 496
+ ++Q+ LE+HK L + +A + + + + + DQL+ + ER+
Sbjct: 451 DDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERW 510
Query: 497 HFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRESVEQLLQNYVSFIEN 556
V +E +++ + + L L+ + LK+W+ + + E++ + ++
Sbjct: 511 TAVCRWTEERWNRLQEINI---LWQELLEEQCLLKAWLTE--KEEALNK--------VQT 557
Query: 557 SKFFEQYEVTYQ-----ILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSV 611
S F +Q E++ ILK+ EM + + E + + Q + S + +
Sbjct: 558 SNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE-------IGQDVGQLLDNSKASKKI 610
Query: 612 RSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAG 671
S EE+ WD + + A L S+ +KD
Sbjct: 611 NSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLET--------------- 655
Query: 672 NFLIETCDEMVSRDLKQQL-LLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVVT-LSA 729
+ ++ +++ KQ+L + R++ ++++ + D + E + ++ +A
Sbjct: 656 ---VRVREQAITKKSKQELPPPPPPKKRQIHVDIE---AKKKFDAISAELLNWILKWKTA 709
Query: 730 FATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEG 789
T K+ + + S M KL + E +R+P D + +T ++ ++ G
Sbjct: 710 IQTTEIKEYMKMQDTSEMKKKLKALEKEQ-RERIPRADE----LNQTGQILV----EQMG 760
Query: 790 KEMFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLE 849
KE T ++K L KV + + + L + +L++ + +++ L ++ ++I E
Sbjct: 761 KEGLPT-EEIKNVLEKVSSEWKNVSQHLEDLERKI-QLQEDINAYFKQLDELEKVIKTKE 818
Query: 850 REAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIA 909
+ +++ + Q L + +++C++ LT +
Sbjct: 819 EWVKHTSISESSRQSLPSLKDSCQRELT-----------------------------NLL 849
Query: 910 DIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRR 969
+H + + + F+ + V QE +E++ ++
Sbjct: 850 GLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAV----QEAVEDR-------QQ 898
Query: 970 HTEFFSQLDQRVLNAFLKACDELTDILPEQEQ--QGLQEAVRKLHKQWKDLQGEAPYHLL 1027
H E ++L + +A+L+ L D+L + E Q + L K K LQ +
Sbjct: 899 HLE--NELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTL--- 953
Query: 1028 HLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSD-KGPHH----LCE 1082
+ L + + +L ETK + + + K ++ F D +G + L
Sbjct: 954 --------DEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS 1005
Query: 1083 KRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDK--WKDYTSRF 1140
K L L+EE+ + L R V K + D ++ D + +
Sbjct: 1006 KDLHLLEEIALTL------RAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQC 1059
Query: 1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTE 1200
S F + I T E+ LK +K I+T +R+G +T W+++RL
Sbjct: 1060 SAFVNEIETIESSLKNMK--EIET-----------NLRSGPVAGIKT--WVQTRL----- 1099
Query: 1201 VSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF-GDCVQYKEIVKNSLEELISGS 1259
+ Q Q L KLS + LSE ++ +N D + +E + + EE +
Sbjct: 1100 ----GDYQTQ---LEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERD 1152
Query: 1260 KEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHE 1319
E + E E + A++ +L QK R+ K +++ A+ +P G E
Sbjct: 1153 FEYKSPEELESAVEEMKRAKEDVL---QKEVRVKILKDNIKLLAAK-------VPSGGQE 1202
Query: 1320 ELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSL 1379
+L L+ + R + W + + L H L + L
Sbjct: 1203 LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCW-------IELL------HYLDLETTWL 1249
Query: 1380 ESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED 1439
+L ++ T+ ++T+++ E+L + +L+ A + + Q+++L
Sbjct: 1250 NTLEERMKSTEVLPEKTDAVNEALESL-------------ESVLRHPADN-RTQIRELGQ 1295
Query: 1440 TLEEDIKTMEMVKTKWDHFGSNFETLSVWITEK----EKELNALETSSSAMDMQISQIKV 1495
TL + +++ K + F S +E LS K EK+L L + D + ++
Sbjct: 1296 TLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRET----DQMLQVLQE 1351
Query: 1496 TIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCL----- 1550
++ E++ +L++ + +A F E+ +I+A+++ EELR + +
Sbjct: 1352 SLGELDKQLTTYLTDRIDA-----FQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSP 1406
Query: 1551 EGTILGHLSQQQKFEENLRKIQ------QSVSEFE----------DKLAVPIKICSSATE 1594
E SQ + LR++ Q + FE D + + +
Sbjct: 1407 ESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDV 1466
Query: 1595 TYKVLQEHMDLC----QALESLSSAITAFSASARKVV------NRDSCVQEAAALQQQYE 1644
V+Q H+D C + L + + + R +V N ++ +L+ Y
Sbjct: 1467 DPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYN 1526
Query: 1645 DILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEA----KASSP----EMDISADR 1696
D+ + E + LE ++++KE +S WL E K++S ++D
Sbjct: 1527 DLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISW 1586
Query: 1697 VK-VEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRD 1755
K V +L+ +A N + ++ L++ E + ++ L L+ W
Sbjct: 1587 AKNVLKDLEKRKADLNTITESSAALQNLIEGSEPI-----------LEERLCVLNAGWSR 1635
Query: 1756 LPQIINKRINFLQSVVAEHQQFDELLLSFSVWI---KLFLSELQ---TTSEISIMDHQVA 1809
+ N L + + + FD + S W+ + L E++ T+ + I+ V
Sbjct: 1636 VRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLV- 1694
Query: 1810 LTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVER 1869
+E++ ++++++ L + + L++ K + + FE+ SQ ++
Sbjct: 1695 --------SELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKS 1746
Query: 1870 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDL------IEKDLNDALQNA 1923
+L ++ Q + + +T + + K E+D+ +EK L + ++
Sbjct: 1747 AKLLIA------QEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDE 1800
Query: 1924 KALESAAVSLDGILSKAQYHL-KIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADA 1982
K E +A ++ +L + + L + ++ R L +I+ + +Q +
Sbjct: 1801 KMDEESA-QIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIK-AIPIQQRKMGQ 1858
Query: 1983 LA------VLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELN 2036
LA +L + + ++L ++D+E + L + + ++D+L+
Sbjct: 1859 LASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLD 1918
Query: 2037 SHEHELCWLKDKAKQ-IAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLM 2095
++ + +K I + A ++ + +L WD R+ + +G ++
Sbjct: 1919 KLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEW 1978
Query: 2096 REYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSK 2155
R++ + +++ + A ++V DL+ A + + ++ Q
Sbjct: 1979 RQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRT 2038
Query: 2156 GKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDE 2215
G + ++K+ +D S +K + +W + ++++ RL+ DE
Sbjct: 2039 GDGI---VQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDE 2095
Query: 2216 IEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKALRLEELHSKVNDLKELTKNL 2275
I W +AE +++ + EL + +L++LT+ +
Sbjct: 2096 IICWLT-----------------KAEHAMQKRST---------TELGENLQELRDLTQEM 2129
Query: 2276 ETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESL- 2334
E HA+++ + + L+ + +S + + K+ ESL
Sbjct: 2130 EV----------------HAEKLKWLNRTELEMLSDKSLSLPE--------RDKISESLR 2165
Query: 2335 -MNCAQNETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLI 2393
+N N+ C ++V KE + S++S T+ + +K +
Sbjct: 2166 TVNMTWNKIC---REVPTTLKECIQEPSSVSQTRIAAHPNVQK----------------V 2206
Query: 2394 KKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL 2453
+ S + ++ + + S+ +++ E +W + K + GD + + +
Sbjct: 2207 VLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTV 2266
Query: 2454 HDLQNILDSVSDGQSKLDAVTQEGQTLYAHL-SKQIVSSIQEQITKANEEFQAFLKQCLK 2512
++ + +LD V Q L S + ++I E++ + ++
Sbjct: 2267 SRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVEL 2326
Query: 2513 DKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKK---NEVHKVEM 2569
+Q L+D + ++D + + + E R L ++++ K+ N++ E+
Sbjct: 2327 RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYI--LQQARRDPLTKQISDNQILLQEL 2384
Query: 2570 FLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLL-TSHQNLLRMTKEKLRSCQV 2628
G+ + + D + Q+ LL E G + + ++ L TS NL + ++ + +
Sbjct: 2385 GPGDGIVM--AFDNVLQK--LLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEA 2440
Query: 2629 ALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKG------ 2682
+ +A L++ W++ AE+T+ R + +QD +L +
Sbjct: 2441 EWRTVQASRRDLENFLKWIQE-------AETTVNVLVDASHRENALQDSILARELKQQMQ 2493
Query: 2683 --EGEVKLNMAIGKGEQALRS------SNKEGQRVIQTQLETLKEVWADIMSSSVHAQST 2734
+ E+ + I K R N E ++Q +L+ + + W D+ + S ++
Sbjct: 2494 DIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAH 2553
Query: 2735 LESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHT 2794
LE+ +WN + +L +W+ D++++ + + + DH +++ E ++
Sbjct: 2554 LEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKE 2613
Query: 2795 RALHRLIAKSRELYEKTEDESFKDTAQE-ELKTQFNDIMTVAK--EKMRKVEEIVKDHLM 2851
++ + ++R E+ ++ + + KT+ K + MRK VK+
Sbjct: 2614 YSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWE 2673
Query: 2852 YLDAVHEFTDWLHSAKEELHRWSDMSG---DSSATQKKLSKIKE--------LIDSREIG 2900
L+AV ++W + L + D+ G D A K+ ++ LIDS +
Sbjct: 2674 SLNAV--TSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDH 2731
Query: 2901 ASRLSRV-ESLAP---EVKQ----NTTASGCEL-----MHTEMQALRADWKQWEDSVFQT 2947
++ E +AP +VK ++ S +L M ++ L WK + SV
Sbjct: 2732 IEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDR 2791
Query: 2948 QSCLENLVSQMALSEQEFSGQVAQL 2972
L+ S Q F QL
Sbjct: 2792 LKQLQEAHRDFGPSSQHFLSTSVQL 2816
Score = 154 bits (388), Expect = 5e-36
Identities = 505/2769 (18%), Positives = 1069/2769 (38%), Gaps = 385/2769 (13%)
Query: 2716 TLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
T+ EV D+ S + + L ++S + + E+ + + E DQ H E
Sbjct: 303 TVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATH---------E 353
Query: 2776 KFV--LLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMT 2833
F+ L H S+ S + + + + E +E E + + E L+ + D +
Sbjct: 354 AFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQS 413
Query: 2834 VAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSD--MSGDSSATQKKLSKIK 2891
+ + E+ K L L A WL +E + + + D + QK L + K
Sbjct: 414 RLHDVLM---ELQKKQLQQLSA------WLTLTEERIQKMETCPLDDDVKSLQKLLEEHK 464
Query: 2892 ELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWK---QWEDSVFQTQ 2948
L E +++ + + V +N+ S ++ ++Q L W +W + +
Sbjct: 465 SLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL 524
Query: 2949 SCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHK 3008
+ N++ Q L EQ LLK W T++E
Sbjct: 525 QEI-NILWQELLEEQ-----------------CLLKAWL----------TEKE------- 549
Query: 3009 GQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNK 3068
+AL K + T + K Q ++LS +++ ++KE + K
Sbjct: 550 -----EALNKVQ--TSNFKDQ--------KELSVSVRRLA-ILKE----------DMEMK 583
Query: 3069 EQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKL 3128
Q L Q + +D Q L N+K + D + + +Q++++ ++ KL
Sbjct: 584 RQTLDQ-LSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL 642
Query: 3129 NM-MLSKGELLSTLLTKEKA---KGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKD 3184
M + + +LL T+ +E+A K Q + H ++ K K
Sbjct: 643 GMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAK-----------KK 691
Query: 3185 FEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRRE-QQKLQSVLEEIHCYEPQLNRLKEK 3243
F+ + + +W+ K + + + + Y E ++KL+++ +E P+ + L +
Sbjct: 692 FDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQT 751
Query: 3244 AQQLWEGQAA----SKSFRHRVSQLSSQYLALSNLTKE---KVSRLDRIVAEHNQFS--- 3293
Q L E ++ ++ + ++SS++ +S ++ K+ + I A Q
Sbjct: 752 GQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELE 811
Query: 3294 LGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGES 3353
IK ++W+ H S S S+ DS +L LL + K+ + R
Sbjct: 812 KVIKTKEEWVK---HTSISESSRQSLPSLKDSCQRELTNLLG------LHPKIEMARASC 862
Query: 3354 VLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWT--SYQDGVRQFSGW 3411
+ P +Q+ S + ++ A + LE L +Y + ++
Sbjct: 863 SALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDV 922
Query: 3412 MDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETI--EVKGAGMTEH--- 3466
++ E S +L L + K L+E + + L + E K H
Sbjct: 923 LNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDV 982
Query: 3467 -YVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL---------- 3515
+ + E D+Q ++ ++ + + E++ + ++ D E W+
Sbjct: 983 EKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQ 1042
Query: 3516 ----GQE---QEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQ-ALLNSVLHTREDVI 3567
G + Q +LDQ S + T E++L++++E++ + G A + + + TR
Sbjct: 1043 QAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTR---- 1098
Query: 3568 PSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDE-WLKTAEE 3626
G Q + LE L ++ + RLSE++ + N+ L M++ Q +E +L+ E
Sbjct: 1099 -LGDYQTQ---LEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFE 1154
Query: 3627 KKWHEEVTAYRDEVEEVGARAQEILDESHVN------------SRMGCQATQLTSR---- 3670
K EE+ + +E++ RA+E + + V +++ +LTS
Sbjct: 1155 YKSPEELESAVEEMK----RAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVV 1210
Query: 3671 ---YQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVM 3727
YQ L ++ + LEE E L + W + + K+ +K D V
Sbjct: 1211 LENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAV- 1269
Query: 3728 MGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVK--YLEEGEAERLRKEIHDHMEQLKEL 3785
+ L++LE +L+ + + RE G+ + L++ +E+L + + E L L
Sbjct: 1270 -NEALESLESVLRHPADNRTQI---RELGQTLIDGGILDDIISEKL-EAFNSRYEDLSHL 1324
Query: 3786 TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYK 3845
+ + ++LEK L + +E + L + + E + L +++ ++ + K
Sbjct: 1325 AES---KQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQK-- 1379
Query: 3846 SLQQTVLSHEPSVKSVREKGEAL-LELVQDVTLK--DKIDQLQSDYQDLCSIGKAMMEEI 3902
+Q + +HE +++ +R + L + T + ++D LQ +++ S + ++
Sbjct: 1380 -IQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREV-STKFQLFQKP 1437
Query: 3903 AGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH 3962
A FE R+ + + + D ++A+L H+ KD +
Sbjct: 1438 ANFEQRMLDCK--------RVLDGVKAEL------HVLDVKDVDPDV------------- 1470
Query: 3963 ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLL 4022
+Q H+ D + LS V+ ++E IK +H Q+
Sbjct: 1471 -IQTHL---DKCMKLYKTLSEVKLEVET----------VIKTGRHIVQKQQTDNP----- 1511
Query: 4023 CSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQL 4082
D S+K D+ +Q L +A L + ++K + L +L + +L
Sbjct: 1512 -KGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLAR---KMKKEAASLSEWLSATETEL 1567
Query: 4083 QNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPE---HKE 4139
+++ SE L +S K+ +K L+ ++A +NTI E L E E +
Sbjct: 1568 --VQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEER 1625
Query: 4140 INHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAES 4199
+ LN W + + + C + + + + +L + D + + +
Sbjct: 1626 LCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEK---KP 1682
Query: 4200 TAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLED 4259
T+ E +K+L L + +E+++DQ ++ +ELV+ + + L + + ++
Sbjct: 1683 TSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQ 1742
Query: 4260 LIKR-KIQVSVTNLEELNVVQSRFQELMEWAE-EQQPNIAEAL-----KQSPPPDMAQNL 4312
IK K+ ++ L + V F+ + +++ E+ N E + K D + +
Sbjct: 1743 HIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKM 1802
Query: 4313 LMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQ 4372
+ I L+ + +L ++D N+++ I+ L + N + + Q
Sbjct: 1803 DEESAQIEEVLQRGEEMLHQPMED----------NKKEKIRLQLLLLHTRYNKIKAIPIQ 1852
Query: 4373 RRKYLNKALSEK-----TQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKS 4427
+RK A + T +L+ + + + E + E + +D S Q + K+
Sbjct: 1853 QRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKN 1912
Query: 4428 AQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELE 4487
+ L ++ + + +++ E + E ++ L +L + +D + + S R +
Sbjct: 1913 IKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFD 1972
Query: 4488 KNLVSRKHFKEDFDKACHWLKQADIVTF----PEINLMNESSELHTQLAKYQNILEQSPE 4543
+ + + F D + W+ +A+ + P +L E + +H Q + I P
Sbjct: 1973 RAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEV-GISSHQPS 2031
Query: 4544 YENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARK 4603
+ L RTG I+ L++ D S+L EKL L ++++ IVA KD+ +++
Sbjct: 2032 FA----ALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVM 2087
Query: 4604 EYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELN 4663
+Y ++ L++ E + S T+L L E+ L + ++
Sbjct: 2088 KYRHQLDEIICWLTKAEHAMQKRS--TTELGEN------------LQELRDLTQEMEVHA 2133
Query: 4664 QKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQL 4723
+K + T DK L L +R + E + K+C+++ L
Sbjct: 2134 EKLKWLNRTELEMLSDKSLSL-----------PERDKISESLRTVNMTWNKICREVPTTL 2182
Query: 4724 KSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYEKA 4783
K +E S V++ + A ++ L S D + + + P +K
Sbjct: 2183 KECIQEPSSVSQTRIAAHPNVQKV-VLVSSASD-------IPVQSHRTSEISIPADLDKT 2234
Query: 4784 RHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGP---- 4839
++ W + + + TV + E E+++++ ++ KA+L
Sbjct: 2235 ITELADWLVLIDQMLKSNIVTVGDVE-----------EINKTVSRMKITKADLEQRHPQL 2283
Query: 4840 VYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAEL 4899
Y+ Q+++ + + + R+ N + + EL LE + +
Sbjct: 2284 DYVFTLAQNLKNKASSSDMRTAITEKLERVKN-----QWDGTQHGVELRQQQLEDMIIDS 2338
Query: 4900 SELDG---DIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVES 4956
+ D + +E +R +A L I Q +R + D Q LLQ G G +
Sbjct: 2339 LQWDDHREETEELMRKYEARL-YILQQARR-----DPLTKQISDNQILLQELGPGDGIVM 2392
Query: 4957 AEEN-LKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMS 5015
A +N L+ +E + ++D N++E + T +K + + Q E R+ + S
Sbjct: 2393 AFDNVLQKLLEEYGSDDT--RNVKETTEYLKTSWINLKQSIAD--RQNALEAEWRTVQAS 2448
Query: 5016 RDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHK 5075
R R + + + E + ++ D + E +L + + E ++++ + +
Sbjct: 2449 R----------RDLENFLKWIQEAETTVNVLVDASHR--ENALQDSILARELKQQMQDIQ 2496
Query: 5076 ALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKIL 5135
A + N + I +K ++ GN L + + QRW L+A + L
Sbjct: 2497 AEIDAHNDIFKSIDGNRQK--MVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHL 2554
Query: 5136 EDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQS 5195
E + ++W +++ + ++ ++L L ++ EL++++
Sbjct: 2555 EASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEY 2614
Query: 5196 ALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAM--QDRCLNMQEKVKTNGKLVKQELKD 5253
++ Q L D P E +Q T + ++R + + ++ VK++ +
Sbjct: 2615 SVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWES 2674
Query: 5254 REMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQ-----------ILLTEATNHRQN 5302
V + E L ++DA ++E + +L+ +H +
Sbjct: 2675 LNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEK 2734
Query: 5303 IEKMAEEQKEKYLGLYTILPSELSLQLAEVAL--DLKIRDQIQDKIKEVEQSKATSQELS 5360
I EE + T+ ++LS QL+ + L LK+ Q+ D + + + +
Sbjct: 2735 IMAFREEIAPINFKVKTV--NDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRL 2792
Query: 5361 RQIQKLAKD 5369
+Q+Q+ +D
Sbjct: 2793 KQLQEAHRD 2801
Score = 149 bits (377), Expect = 9e-35
Identities = 499/2704 (18%), Positives = 1042/2704 (38%), Gaps = 386/2704 (14%)
Query: 5881 SEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPES---QMAEHQALMD 5937
+E T+ E YQ +L+ + T + + E E + E Q A H+A M
Sbjct: 298 AETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMM 357
Query: 5938 EILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLL 5997
E+ Q + + + +L+++ +D E+ +Q +T+L R +R+++ +
Sbjct: 358 ELTAHQSSVGSVLQA-GNQLITQGTLSDE-EEFEIQEQMTLLNARWEALRVESMDR---- 411
Query: 5998 EEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQN 6057
+ +L+D L E +++Q Q L +WL T+ + + P + D ++
Sbjct: 412 QSRLHDVLMELQKKQLQQ--------LSAWLTLTEERIQKMETCPLDD--------DVKS 455
Query: 6058 MLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQL 6117
+ +E+ S+L E + + H ++ +G E A+ + QL
Sbjct: 456 LQKLLEEHKSLQSDLEA--EQVKVNSLTHMVVIVDENSG----------ESATAILEDQL 503
Query: 6118 NMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLL 6177
G + W A R WT++R + LQ+ L QEL E++ LL
Sbjct: 504 QKLG--------------------ERWTAVCR--WTEERWNRLQEINILWQELLEEQCLL 541
Query: 6178 RSVASRGEEILIQHSAAETSGDAGEKP--------DVLSQELGMEGEKSSAEDQMRMKWE 6229
++ + EE L + +TS +K +L +++ M+ + ++
Sbjct: 542 KAWLTEKEEAL---NKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVG 598
Query: 6230 SLHQEFSTKQKLLQNVLEQEQE-----QVLYSRPNRLLSGVP-LYKGDVPTQDKSAVTSL 6283
L +K+ + E Q Q L N++ V L +P +D +
Sbjct: 599 QLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRV 658
Query: 6284 LDGLNQAFEEVSSQS----GGAKRQSIHLE---QKLYDGVSATS-TWLDDVEERLFVATA 6335
+ QA + S Q K++ IH++ +K +D +SA W+ ++ + + T
Sbjct: 659 RE---QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWI--LKWKTAIQTT 713
Query: 6336 LLPE-----ETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL 6390
+ E +T + L K+ +E D+ N Q E + + + +
Sbjct: 714 EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADE-LNQTGQILVEQMGKEGLPTEEIKNV 772
Query: 6391 LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAE 6450
L ++S V+Q ++ ++Q Q D+ F L + + +I K V ++E
Sbjct: 773 LEKVSSEWKNVSQHLEDLERKIQ----LQEDINAYFKQLDELEKVIKTKEEWVKHTSISE 828
Query: 6451 QI-EAIQQAEDGLKEFDAGI------IELKRRGDKLQVEQPSMQEL-----SKLQDMYDE 6498
+++ +D + + IE+ R + QPS + Y
Sbjct: 829 SSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQA 888
Query: 6499 LMMIIGSRRSGLNQNLTLKSQ----YERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQ 6554
+ + R+ L L K Q Y L+ L D+L + K ++ + ++++
Sbjct: 889 VQEAVEDRQQHLENEL--KGQPGHAYLETLKTLKDVLNDSENKAQVSLNVL-NDLAKVEK 945
Query: 6555 LLDKHKEYFQGLES-----HMILTET-LFRKIISFAVQK-ETQFHTELMAQASAVLKRAH 6607
L + K + LE+ H + ET K + V+K Q ++ + + +
Sbjct: 946 ALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVS 1005
Query: 6608 KRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENE---DRLIDRITLY--- 6661
K LE I T + D + + ++ V+ + + ++ R +D+ + +
Sbjct: 1006 KDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNE 1065
Query: 6662 -QHLKSSLN---EYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELH 6717
+ ++SSL E + L G + + D ++QL +L + + +++S+
Sbjct: 1066 IETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQE 1125
Query: 6718 RLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQ-SVTVPQELEMVRDHLNAFLEFSK 6776
+ + K + A++ W+ A++ E+ + P+ELE + + +K
Sbjct: 1126 KAANLKK-------DLAEMQEWMTQAEE--EYLERDFEYKSPEELESAVEEMKR----AK 1172
Query: 6777 EVDAQSSLKSSVLSTGNQLLRLKKVDTAT-LRSELSRIDSQWTDLLTNIPAVQEKLHQLQ 6835
E Q ++ +L +LL K L SEL+ + + L I L ++
Sbjct: 1173 EDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVW 1232
Query: 6836 MDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKID--INCKQ 6893
+ H + +W++ +E ++ E + + E L+ D ++
Sbjct: 1233 SCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRE 1292
Query: 6894 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 6953
L ++ +L D+ S E+L A N ++ L L K LE L+
Sbjct: 1293 LGQTLIDGGILD----DIIS---------EKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339
Query: 6954 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013
E + +Q L+ +K+L + D+ ++ Q ++ I A E +E++ +N
Sbjct: 1340 RETDQMLQVLQESLGELDKQLTTY--LTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397
Query: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073
+ + ++S T R G +L+ L + S+ F K +
Sbjct: 1398 ------MRSQPLTSPESRTARG------------GSQMDVLQRKLREVSTKFQLFQKPAN 1439
Query: 7074 Y---LMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKEC 7130
+ +++ + L + L+ V D +Q D K ++L + ++K
Sbjct: 1440 FEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTG 1499
Query: 7131 HPPVTETLTNT-------LKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCAST 7183
V + T+ L + + +N+L ++ E Q + QL ++ K K+ AS
Sbjct: 1500 RHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMK---KEAASL 1556
Query: 7184 VQQQEDRTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQV 7243
+ EL++ +T++ + D + T I ++LK L K L + E L+ +
Sbjct: 1557 SEWLSATETELVQKSTSEGLLGD-LDTEISWAKNVLKDLEKRKADLNTITESSAALQNLI 1615
Query: 7244 DASAASAIQSDQLSLSQHLCALEQALCKQQT-------SLQAGVLDYETFAKSLEALEAW 7296
+ S + L + LC L + +T +L E F ++ + W
Sbjct: 1616 EGS--------EPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTW 1667
Query: 7297 IVEAEEILQGQDPSHSSDLSTIQERM-EELKGQMLKFSSMAPD-LDRLNELGYRLPLNDK 7354
+ +AE +L + +S I +R+ EL L+ ++ L +N G + +
Sbjct: 1668 LYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGS----SSR 1723
Query: 7355 EI--KRMQNLNRHWSLISSQT-TERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVE 7411
E+ ++ LNR++ +S + + Q L Q E ET + F +KL +
Sbjct: 1724 ELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPF--SDLEKLEND 1781
Query: 7412 ISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDE-FNLKLTLLS 7470
I N +E+ +M + ++ G+ +L Q D++ E L+L LL
Sbjct: 1782 IE-NMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLH 1840
Query: 7471 NQWQGV--IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQ 7528
++ + I Q++ G + S IR + ++ K L+ + + +S + +P +
Sbjct: 1841 TRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELS----LNVP-EL 1895
Query: 7529 ARTLFDEVQFKE------KVFLRQQGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQE 7581
++++ F+E K L + G I + + ++ SG EA ++ L ++
Sbjct: 1896 NTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNA 1955
Query: 7582 KWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSL-PDHHEELHAEQ 7640
KW + ++K +++W + + D + + ++ L + P +L +
Sbjct: 1956 KWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKAR 2015
Query: 7641 MRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLR 7700
+ +ELE + S L+ D + +S D S L E++ L ++W+ + ++ R
Sbjct: 2016 IHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDR 2075
Query: 7701 RQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQE 7760
+ ++ + + + E+ WLT+ E + + + E +++L +D +E+ + E
Sbjct: 2076 QPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQEL-RDLTQEMEVHAE 2134
Query: 7761 -----NKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKK------- 7808
N+ +L+ + ++ K SE L VN W + + +K+
Sbjct: 2135 KLKWLNRTELEMLSDKSLSLPERDKISE---SLRTVNMTWNKICREVPTTLKECIQEPSS 2191
Query: 7809 LKETLVAVQ-----------------------------QLDKNMSSLRTWLAHIESELAK 7839
+ +T +A LDK ++ L WL I+ L
Sbjct: 2192 VSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKS 2251
Query: 7840 PIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7899
IV + EEI + ++ + + D+E+ + V L + L + A ++D +I
Sbjct: 2252 NIVTVG-DVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKN--KASSSDMR-TAIT 2307
Query: 7900 QATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSER-TAAFPSSSG 7958
+ + +W R+ ++E+ + D +++D + +E + +
Sbjct: 2308 EKLERVKNQWDGTQHGVELRQQQLED-------MIIDSLQWDDHREETEELMRKYEARLY 2360
Query: 7959 VIYTVAKEELKKFEAFQRQVHECLTQ--------LELINKQYRRLARENRTDSACSLKQM 8010
++ ++ L K Q ++ L Q + + ++L E +D ++K+
Sbjct: 2361 ILQQARRDPLTK----QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKET 2416
Query: 8011 VHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFS--E 8068
W NL++ + L+ + ++ L W+ E + + + S E
Sbjct: 2417 TEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRE 2476
Query: 8069 CDVQAKI--KQLKAFQQEISLN---HNKIEQIIAQGEQLIEKS--EPLDAAIIEEELDEL 8121
+Q I ++LK Q+I HN I + I Q + K+ +A +++ LD++
Sbjct: 2477 NALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM 2536
Query: 8122 RRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQ 8181
+ ++ + IR L + + LE+ + W + + L
Sbjct: 2537 NQRWNDL-----KAKSASIRAHLEASAEKWNRLLMSLEEL-----IKWLNMKDEELKKQM 2586
Query: 8182 PSSNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLE-------SAMSRA--- 8231
P G D PA + L++DH L R+L+ +A+ +A
Sbjct: 2587 P----------------IGGDVPA----LQLQYDHCKALRRELKEKEYSVLNAVDQARVF 2626
Query: 8232 ---------------LPSEDEEGQDDKDFYLRGAVGLSDVMIPESPEAYVKLTENAIKNT 8276
L S+ E +++ + A+ + E E+ +T N K
Sbjct: 2627 LADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQV 2686
Query: 8277 SGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSI 8336
ALE ++R L A+DD +++ E++ P G L S + +++ + I
Sbjct: 2687 D---KALE-KLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEI 2742
Query: 8337 DSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVID---RWELLQAQALSKELRMKQNLQK 8393
+ + K + S ++LH + + + D RW+LLQ +S + R+KQ +
Sbjct: 2743 API-NFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQ---VSVDDRLKQLQEA 2798
Query: 8394 WQQF 8397
+ F
Sbjct: 2799 HRDF 2802
Score = 141 bits (355), Expect = 3e-32
Identities = 508/2716 (18%), Positives = 1033/2716 (38%), Gaps = 477/2716 (17%)
Query: 5305 KMAEEQKEKYLGLYTILP--------SELSLQLAEVALDLKIRDQIQDKIKEVEQSKATS 5356
K +E +E+ + + + P +E + EV +DL D Q ++EV ++
Sbjct: 272 KYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDL---DSYQIALEEVLTWLLSA 328
Query: 5357 QELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFL 5416
++ ++ ++ D+ + + +++ Q +G L N + + + ++
Sbjct: 329 EDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEF 388
Query: 5417 EQNGQLGKPLAKKIGKLTELHQQTIR-QAENRLSKLNQAASHLEEYNEMLELILKWIEKA 5475
E Q+ L + +R ++ +R S+L+ L++ + L+ + W+
Sbjct: 389 EIQEQM---------TLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWL--- 434
Query: 5476 KVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVY--------- 5526
L I L + Q LLEE K + S+LEA K+ LT +
Sbjct: 435 -TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGE 493
Query: 5527 -CTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLT 5585
T + Q+ +LG + + + R LQ+ ++ E L+A L + + L
Sbjct: 494 SATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALN 553
Query: 5586 SPEVGRLSLKEQLS---HRQHLLSEMESLKPKV--QAVQLCQSALRIPEDVVASLPLCHA 5640
+ +++LS R +L E +K + Q ++ Q ++ ++ AS +
Sbjct: 554 KVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSD 613
Query: 5641 ALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNI 5700
+ L + L N + AV + + K L + + + ++ + +
Sbjct: 614 SEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETV-----RVREQAITKKSK 668
Query: 5701 QEL-------QAQISRHEELAQKIKGYQEQIAS--LNSKCKMLTMKAKHATMLLTVTEVE 5751
QEL + QI E +K ++ + L K + T + K + +E++
Sbjct: 669 QELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMK 728
Query: 5752 GLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSP 5811
+ E E +P A + + E+ G+EG +E +
Sbjct: 729 KKLKALEKEQRERIP-----------RADELNQTGQILVEQMGKEGLPTEEIKNVLEKVS 777
Query: 5812 SPVANTD---------ASVNQDI-AYYQALS--AERLQTDAAKI-HPSTSASQEFYEPGL 5858
S N + +DI AY++ L + ++T + H S S S P L
Sbjct: 778 SEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSL 837
Query: 5859 EPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQ----SISTKMEAIELK 5914
+ S +L +L + E R AL Q D +Q S + +A++ +
Sbjct: 838 KDSCQRELTNLLGLHPKI-----EMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQ-E 891
Query: 5915 LSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQS 5974
E + E + A ++ + L+D +N+ ++ L + A + L +
Sbjct: 892 AVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKK 951
Query: 5975 TLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
TL + E K + + + LE+ ++ +E + Y+ E D++ K
Sbjct: 952 TLDEILENQKPALHKLAEETKALEKNVHPDVE--------KLYKQEFDDVQGKWNKLKVL 1003
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
+ L +E + + + + + ++E V ++ L++ +A D+A L
Sbjct: 1004 VSKDLHLLEE-IALTLRAFEADSTVIEKWMDGV---------KDFLMKQQAAQGDDA-GL 1052
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+L + + E++ ++ + + +E + +L + G++ TW Q
Sbjct: 1053 QRQLDQCSAFVNEIE--------TIESSLKNMKEIETNLRSGPVAGIK--------TWVQ 1096
Query: 6155 QRQSSLQQQKE-LEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGM 6213
R Q Q E L +E+A QKS L Q AA D E QE
Sbjct: 1097 TRLGDYQTQLEKLSKEIATQKSRLSE---------SQEKAANLKKDLAE-----MQEWMT 1142
Query: 6214 EGEKSSAEDQMRMKW-ESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDV 6272
+ E+ E K E L ++ ++VL++E R L + L V
Sbjct: 1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKE------VRVKILKDNIKLLAAKV 1196
Query: 6273 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQ------KLYDGVSATSTWLDDV 6326
P S L LN E + + LE+ +L + +TWL+ +
Sbjct: 1197 P----SGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTL 1252
Query: 6327 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDT 6386
EER+ +T +LPE+T+ + E E ++ DNR I +
Sbjct: 1253 EERM-KSTEVLPEKTDA-----------VNEALESLE-------SVLRHPADNRTQIRE- 1292
Query: 6387 LGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQ 6446
LG L +LD +++++ R + + + LA++K I L+K V
Sbjct: 1293 LGQTLIDGGILDDIISEKLEAFNSRYEDL-----------SHLAESKQISLEKQLQV--- 1338
Query: 6447 PVAEQIEAIQQAEDGLKEFDAGIIE-LKRRGDKLQVEQPSMQ---ELSKLQDMYDELMMI 6502
+ E + +Q ++ L E D + L R D QV Q + + E+S + +EL
Sbjct: 1339 -LRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEEL--- 1394
Query: 6503 IGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY 6562
RR+ +Q LT D+L+ +++ ++ Q++LD K
Sbjct: 1395 ---RRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLD-CKRV 1450
Query: 6563 FQGL--ESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETW 6620
G+ E H++ + + +I Q H + + + K + +E+E +++T
Sbjct: 1451 LDGVKAELHVLDVKDVDPDVI--------QTHLD---KCMKLYKTLSEVKLEVETVIKTG 1499
Query: 6621 SHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLD 6680
H+ + QQ +N + +++T + L + L +
Sbjct: 1500 RHIVQKQQ-------------------TDNPKGMDEQLTSLKVLYNDLGAQ-------VT 1533
Query: 6681 DGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6740
+GK+ DLE + +QL +S+ L ET L + + DL +
Sbjct: 1534 EGKQ--------DLE-RASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEI 1584
Query: 6741 QSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKK 6800
AK+ V ++LE + LN E SS L G++ + ++
Sbjct: 1585 SWAKN-----------VLKDLEKRKADLNTITE--------SSAALQNLIEGSEPILEER 1625
Query: 6801 VDTATLRSELSRI---DSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMEN 6857
+ L + SR+ W + L N HQ Q++ ++ + +W+ E
Sbjct: 1626 L--CVLNAGWSRVRTWTEDWCNTLMN--------HQNQLEIFDGN--VAHISTWLYQAEA 1673
Query: 6858 VIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSD 6917
++ + E K + + K +++ L V+ V L + + ++ S
Sbjct: 1674 LLDEIEK--------KPTSKQEEIVKRLVSELDDANLQVENVRDQALIL----MNARGSS 1721
Query: 6918 KTDFAE-QLGAMNKSWQ-ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLK 6975
+ E +L +N++++ + Q + + K+ + + E QCL T ET E +
Sbjct: 1722 SRELVEPKLAELNRNFEKVSQHIKSAKLLIAQ---------EPLYQCLVT-TETFETGVP 1771
Query: 6976 QQHRIGDQASVQNALK------DCQDLEDLIKAKEKEVEKIEQNGLALI-----QNKKED 7024
+ ++N LK + D ++ + + ++E++ Q G ++ NKKE
Sbjct: 1772 FSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEK 1831
Query: 7025 V--SSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSL 7082
+ +++ T + +GQL ++S L + + V +KI + + SL
Sbjct: 1832 IRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLP-TDYLVEINKILLCMDDVELSL 1890
Query: 7083 SRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTL 7142
+ L T E Q D+L+N++D L+K + ++ E P + +TL
Sbjct: 1891 NVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTL 1950
Query: 7143 KEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATNKD 7202
++N +W+ + +++ ++ W+++ + + E+ + + D
Sbjct: 1951 TQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLD 2010
Query: 7203 IADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHL 7262
+ + +L G+ + + S L+ G+ + Q++ + S ++ L+Q
Sbjct: 2011 LEKARIHQ-----QELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRW 2065
Query: 7263 CALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSH-SSDLSTIQER 7321
A+ + +Q L+ + L+ + W+ +AE +Q + + +L +++
Sbjct: 2066 DAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDL 2125
Query: 7322 MEELK--GQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLI---------- 7369
+E++ + LK+ + +L+ L++ LP DK + ++ +N W+ I
Sbjct: 2126 TQEMEVHAEKLKWLNRT-ELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKE 2184
Query: 7370 -----SSQTTERFS---KLQSFLL----------QHQTF-------LEKCETWM-EFLVQ 7403
SS + R + +Q +L H+T L+K T + ++LV
Sbjct: 2185 CIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVL 2244
Query: 7404 TEQKLAVEI--SGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDD-RD 7460
+Q L I G+ + + + ++ +A++ R L + Q L + D R
Sbjct: 2245 IDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRT 2304
Query: 7461 EFNLKLTLLSNQWQGV-----IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLP 7515
KL + NQW G +R+ Q IIDS QW +RE E+L + Y+
Sbjct: 2305 AITEKLERVKNQWDGTQHGVELRQQQLEDMIIDS--LQWDDHREETEELMRKYEARLYI- 2361
Query: 7516 MSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE 7575
LQQAR Q + L Q+ L G A
Sbjct: 2362 ----------LQQARRDPLTKQISDNQILLQE--------------LGPGDGIVMAFDNV 2397
Query: 7576 LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIAD--------------SLEKLRTF 7621
L ++ E++ S R K+ +L W ++ IAD S L F
Sbjct: 2398 LQKLLEEYGSDDTR--NVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENF 2455
Query: 7622 KKKLSQS------LPD--HHEELHAEQMRCKELENAVGSWTDDLTQLSLL--------KD 7665
K + ++ L D H E + + +EL+ + ++ + + +
Sbjct: 2456 LKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQK 2515
Query: 7666 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWL 7725
+ A ++++ ++L R++ + ++W +L + + R + +W +EL +WL
Sbjct: 2516 MVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWL 2575
Query: 7726 TQMESKVSQ----NGDI----LIEEMIEKLKKDYQEE-------------------IAIA 7758
+ ++ + GD+ L + + L+++ +E+ I
Sbjct: 2576 NMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAP 2635
Query: 7759 QENKIQLQ--------QMGERLAKASHESKASEIEYK---LGKVNDRWQHLLDLIAARVK 7807
+E + LQ + +++AKA + ++SE++ K L V WQ +D ++
Sbjct: 2636 EEPRRNLQSKTELTPEERAQKIAKAMRK-QSSEVKEKWESLNAVTSNWQKQVD---KALE 2691
Query: 7808 KLKETLVAVQQLDKNM 7823
KL++ A+ LD +M
Sbjct: 2692 KLRDLQGAMDDLDADM 2707
Score = 132 bits (332), Expect = 2e-29
Identities = 481/2680 (17%), Positives = 1049/2680 (39%), Gaps = 422/2680 (15%)
Query: 3572 PQAEDRA-LESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKK-- 3628
P+AE + + + D +YQ L E V+ L E FQ+ D+ EE K
Sbjct: 296 PRAETPSTVTEVDMDLDSYQIALEE-------VLTWLLSAEDTFQEQDDISDDVEEVKDQ 348
Query: 3629 --WHE----EVTAYRDEVEEVGARAQEILDESHVNSR----MGCQATQLTSRYQALLLQV 3678
HE E+TA++ V V +++ + ++ + Q T L +R++AL ++
Sbjct: 349 FATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVES 408
Query: 3679 LEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVL 3738
+++ L + + L++ + L S W T + +I K++T + +K+L+ L
Sbjct: 409 MDRQSRLHDVLMELQKKQ--LQQLSAWLTLTEE-------RIQKMETCPLDDDVKSLQKL 459
Query: 3739 LKDMEKGHSLLKSAREKGE---RAVKYLEEGEAERLRKEIHDHMEQLKELTSTV----RK 3791
L++ + S L++ + K V ++E E + D +++L E + V +
Sbjct: 460 LEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEE 519
Query: 3792 EHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKM-ELYEKKAQLSKYKSLQQT 3850
L++ L +E ++ L W+ E +E L+ + + E + + L++
Sbjct: 520 RWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKED 579
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
+ ++ + E G+ + +L+ + KI+ SD ++L ++++ + +++
Sbjct: 580 MEMKRQTLDQLSEIGQDVGQLLDNSKASKKIN---SDSEELTQRWDSLVQRLEDSSNQVT 636
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQG-TKDSYSAICSTA----QRMYQSLEHELQ 3965
K +G + Q L + V Q TK S + ++++ +E + +
Sbjct: 637 QAVAK----LGM-SQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKK 691
Query: 3966 KHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSM 4025
+ L W +A+Q + + + + K +AL+++ R + +
Sbjct: 692 FDAISAELLNWILKWKTAIQTT---EIKEYMKMQDTSEMKKKLKALEKEQRERIPRADEL 748
Query: 4026 CDLSNASVKTTAKDIQQTEQ---TIEQKLVQAQNLTQGWEEIKH---LKSELWIYLQDAD 4079
V+ K+ TE+ +E+ + +N++Q E+++ L+ ++ Y + D
Sbjct: 749 NQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLD 808
Query: 4080 QQLQNMKRR-----HSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKV----NKLTK 4130
+ + +K + H+ + + Q++ S +KD ++ + ++ IE + L
Sbjct: 809 ELEKVIKTKEEWVKHTSISESSRQSLPS-LKDSCQRELTNLLGLHPKIEMARASCSALMS 867
Query: 4131 KEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWD 4190
+ +P+ + D +L + R++ L+ +LE T D
Sbjct: 868 QPSAPDFVQRGF--DSFLGRYQAVQEAVEDRQQHLENELKGQPG----HAYLETLKTLKD 921
Query: 4191 NLARSD--AESTAVHLEALKKLALALQERKYAIEDLKDQK----------QKMIEHLNLD 4238
L S+ A+ + L L K+ ALQE+K E L++QK + + ++++ D
Sbjct: 922 VLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPD 981
Query: 4239 DKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAE 4298
++L K++ ++ +W +L+ L+ + + + LEE+ + F+ E+ + +
Sbjct: 982 VEKLYKQEFDDVQGKWNKLKVLVSKDLHL----LEEIALTLRAFEADSTVIEKWMDGVKD 1037
Query: 4299 AL--KQSPPPDMA--QNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQK 4354
L +Q+ D A Q L A +E+E + LK++ + + + + +Q
Sbjct: 1038 FLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQT 1097
Query: 4355 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
L D Q+ + LS + ++ L+++ + + + + Q E + + R+
Sbjct: 1098 RLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKS 1157
Query: 4415 PDDVSKQVKTCKSA-------QASLKTYQNEVTGLWAQ----GRELMKE---VTEQEK-- 4458
P+++ V+ K A + +K ++ + L A+ G+EL E V E +
Sbjct: 1158 PEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLL 1217
Query: 4459 -SEVLGKLQELQSVYDSVLQKCSHR------LQELEKNLVSRKHFKEDFDKACHWLKQAD 4511
+ + GK L+ V+ ++ + L LE+ + S + E D L+ +
Sbjct: 1218 CNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLE 1277
Query: 4512 IVTFPEINLMNESSELHTQLA-----------KYQNILEQSPEYENLLLTLQRTGQTILP 4560
V + + EL L K + + + +L + Q + + L
Sbjct: 1278 SVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQ 1337
Query: 4561 SLNEVDH--SYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYA------------ 4606
L E D L E L L +Q + D F QEA + E +
Sbjct: 1338 VLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRN 1397
Query: 4607 -----------------SLIELTTQSLSELEAQFLRMSK-----------------VPTD 4632
S +++ + L E+ +F K V +
Sbjct: 1398 MRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAE 1457
Query: 4633 LAVEEALSLQ-DGCRAILDEVAGLGEAVDELNQKKEGFRSTG----QPWQPD-------K 4680
L V + + D + LD+ L + + E+ + E TG Q Q D +
Sbjct: 1458 LHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQ 1517
Query: 4681 MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE--QSKVNEETL 4738
+ L LY+ L Q + LE + ++ +K L L + + E Q +E L
Sbjct: 1518 LTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLL 1577
Query: 4739 -PAEEKLKMYHSLAGSLQDSGIVLKRVT---IHLEDLAPHLDPLAYEKARHQIQSWQGEL 4794
+ ++ ++ L+ L +T L++L +P+ E+ W +
Sbjct: 1578 GDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWS-RV 1636
Query: 4795 KLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIR 4854
+ T T+ ++++ F ++ WL + +A L ++ QEEI
Sbjct: 1637 RTWTEDWCNTLMNHQNQLEI---FDGNVAHISTWLYQAEALLDE---IEKKPTSKQEEIV 1690
Query: 4855 KIQIHQEEVQSSLRIMNALSHK---EKEKFTKAKELISADLEHSLAELSELDGDIQEALR 4911
K ++ E ++L++ N + + ++EL+ E LAEL+ + + ++
Sbjct: 1691 K-RLVSELDDANLQVENVRDQALILMNARGSSSRELV----EPKLAELNRNFEKVSQHIK 1745
Query: 4912 TRQATLT-EIYSQCQRYYQVFQAANDWLE------DAQELLQLAGNGLDVESAEENLKSH 4964
+ + + E QC + F+ + + D + +L+ L ES++E+ K
Sbjct: 1746 SAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHL--ESSDEDEKMD 1803
Query: 4965 MEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLE----------QKVASLELRSQRM 5014
E E+ E LH + + KE + K+ ++ ++ ++M
Sbjct: 1804 EESAQIEEVLQRGEEMLHQPM-------EDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKM 1856
Query: 5015 SR-DSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE 5073
+ SG + LL DY +++ M+D E L+ L T+ + +
Sbjct: 1857 GQLASGIRSSLLPT------DYLVEINKILLCMDDVELSLN-VPELNTAIYEDFSFQEDS 1909
Query: 5074 HKALVSVVNSFHEKIVALEEKASQ--LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQ 5131
K + ++ E+I + EK LE +G +A + + ++T + +W R+ + D+
Sbjct: 1910 LKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQ--IRDTLTQLNAKWDRINRMYSDR 1967
Query: 5132 EKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELE 5191
+ + A++EW F+ + T+ I + ++ L + A S D +
Sbjct: 1968 KGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSL----------DLEKARIH 2017
Query: 5192 QQQSALGMLRQQ----TLSMLQDGAAP--TPGEEPPLMQEITAMQDRCLNMQEKVKTNGK 5245
QQ+ +G+ Q L+ DG + + L +++ + R + +VK
Sbjct: 2018 QQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQP 2077
Query: 5246 LVKQELKDREMVETQINSVKCWVQETKEYL-GNPTIEIDAQLEELQILLTEATNHRQNIE 5304
+K E K Q++ + CW+ + + + T E+ L+EL+ L E H + ++
Sbjct: 2078 RLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLK 2137
Query: 5305 KMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQS-KATSQELSRQI 5363
+ + E L++ +L L RD+I + ++ V + +E+ +
Sbjct: 2138 WLNRTELE---------------MLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTL 2182
Query: 5364 QKLAKDLTTI-------------LTKLKAKTDNVVQA-KTDQKVLGEELDGCNSKLMELD 5409
++ ++ +++ + + + +D VQ+ +T + + +LD ++L +
Sbjct: 2183 KECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWL 2242
Query: 5410 AAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELIL 5469
+ + L+ N +G + E+++ +S++ + LE+ + L+ +
Sbjct: 2243 VLIDQMLKSN-------IVTVGDVEEINK--------TVSRMKITKADLEQRHPQLDYVF 2287
Query: 5470 KWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTE 5529
+ K A S+S +R A+TEKL+ + + +
Sbjct: 2288 TLAQNLKNKA-------SSSDMR--------------------TAITEKLERVKNQW--- 2317
Query: 5530 KMSQQVAELGRETEELRQMIKIRLQ---NLQDAAKDMKKFEAELKKLQAALEQAQATLTS 5586
+Q EL ++L MI LQ + ++ + M+K+EA L LQ A + LT
Sbjct: 2318 DGTQHGVEL--RQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQA---RRDPLTK 2372
Query: 5587 PEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQE 5646
L ++L ++ +++ K+ + E + L + + L++
Sbjct: 2373 QISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKE---TTEYLKTSWINLKQ 2429
Query: 5647 EASRLQHTAIQQCNIMQAAVVQYEQY----EQEMKHLQQLIEGAHRE--IEDKPVA---T 5697
+ Q+ + +QA+ E + ++ + L++ +HRE ++D +A
Sbjct: 2430 SIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELK 2489
Query: 5698 SNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTM---------------KAKHAT 5742
+Q++QA+I H ++ + I G ++++ + TM KAK A+
Sbjct: 2490 QQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSAS 2549
Query: 5743 --------------MLLTVTE-VEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLS 5787
+L+++ E ++ L E+L + +P P+ + + C L
Sbjct: 2550 IRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQ-MPIGGDVPA-LQLQYDHCKALRR 2607
Query: 5788 PVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPST 5847
+ E+ V N +V+Q + E + + T
Sbjct: 2608 ELKEKE------------------YSVLN---AVDQARVFLADQPIEAPEEPRRNLQSKT 2646
Query: 5848 SASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTK 5907
+ E + + + +++ WE+L V S Q+ + +ALE+ + Q ++ +
Sbjct: 2647 ELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDA- 2705
Query: 5908 MEAIELKLSESPEPGRSPESQMA--EHQALMDEILMLQDEINELQSSL--AEELVSESCE 5963
++K +ES G P + Q +++I+ ++EI + + +L S+
Sbjct: 2706 ----DMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSP 2761
Query: 5964 ADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
D L + L L R +++ + + L+E D
Sbjct: 2762 LDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRD 2801
Score = 124 bits (311), Expect = 4e-27
Identities = 465/2705 (17%), Positives = 980/2705 (36%), Gaps = 438/2705 (16%)
Query: 1671 LSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESL 1730
L LTWL E + DIS D +V+ + +A E+ + S +LQ L
Sbjct: 318 LEEVLTWLLSAEDTFQEQD-DISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQL 376
Query: 1731 FSVASKDDVKMMKLHLEQ--LDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWI 1788
+ + D + ++ + L+ RW L R + L V+ E Q+ + L S W+
Sbjct: 377 ITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQK--KQLQQLSAWL 434
Query: 1789 KLFLSELQTTSEISIMDH----QVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAE 1844
L +Q + D Q L HK +++E+++ ++ SL H+ +
Sbjct: 435 TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLT-HMVVIVD----- 488
Query: 1845 DLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSM 1904
+ E + E+ Q + R A+ R T E N +
Sbjct: 489 -----ENSGESATAILEDQLQKLGERWTAVC-------------------RWTEERWNRL 524
Query: 1905 NKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCG 1964
E +++ ++L L+ L++ + L+K Q TS +L
Sbjct: 525 Q--EINILWQEL---LEEQCLLKAWLTEKEEALNKVQ-----------TSNFKDQKELSV 568
Query: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR 2024
V R+ L + + L L + QD + L S + +D E L + +Q+
Sbjct: 569 SVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQR- 627
Query: 2025 LRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREI------NRLEVTWDDTK 2078
LED N + L QI QKD+ V + L K
Sbjct: 628 ------LEDSSNQVTQAVAKLG--MSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKK 679
Query: 2079 RLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKD---QEDLKWAFSKH 2135
R IH + I+ +++ + + + + + I T T IK+ +D K
Sbjct: 680 RQIHVD-------IEAKKKFDAISAELLNWILKWKTAIQT-TEIKEYMKMQDTSEMKKKL 731
Query: 2136 ETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEEN 2195
+ + + + D G+ L+ ++ K +K +E +W +VS+ LE+
Sbjct: 732 KALEKEQRERIPRADELNQTGQILVEQMGK-EGLPTEEIKNVLEKVSSEWKNVSQHLEDL 790
Query: 2196 MDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESEVKNKA 2255
++++ I + DE+E + E + + + + L + + +
Sbjct: 791 ERKIQLQEDI-NAYFKQLDELE----KVIKTKEEWVKHTSISESSRQSLPSLKDSCQREL 845
Query: 2256 LRLEELHSKVNDLKELTKNLETPPDL---------------QFIEADLMQKLEHAKEITE 2300
L LH K+ + L + P Q ++ + + +H + +
Sbjct: 846 TNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELK 905
Query: 2301 VAKG--------TLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDI 2352
G TLKD S + ++ KVE+ AL++ K +
Sbjct: 906 GQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEK------------ALQEKKTL 953
Query: 2353 QKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQE 2412
+ L++Q+ + E +L + H + + + K + L SK L+E
Sbjct: 954 DEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEE 1013
Query: 2413 SLE--KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKL 2470
+ F ++W G K + GD L+ +L ++ + +S L
Sbjct: 1014 IALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSL 1073
Query: 2471 DAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQ 2530
+ + L + I + +Q ++ + + K+ K L + + + +
Sbjct: 1074 KNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKD 1133
Query: 2531 HRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQL 2590
++ W+ + EE + + E ++ V +++ ++L + L +L
Sbjct: 1134 LAEMQEWMTQAEEEYLERDFEYKSPE--ELESAVEEMKRAKEDVLQKEVRVKILKDNIKL 1191
Query: 2591 LSEEGHGAGQEGRLCSQL---LTSHQNLLRM------TKEKLRSCQVALQEHEALEEALQ 2641
L+ + GQE L S+L L ++Q L T E++ SC + L + LE
Sbjct: 1192 LAAKVPSGGQE--LTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETT-- 1247
Query: 2642 SMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRS 2701
W+ +++R+ E D + + L ++ +L + ++ G+ +
Sbjct: 1248 ----WLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIREL---GQTLIDG 1300
Query: 2702 SNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQ 2761
+ +I +LE + D+ + Q +LE + + + L++ + +D+
Sbjct: 1301 GILDD--IISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDK 1358
Query: 2762 KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQ 2821
++ L + + F + Q I +E H L L R S T+
Sbjct: 1359 QLTTYLTDR---IDAFQVPQEAQKIQAEISAHELTLEELRRNMR---------SQPLTSP 1406
Query: 2822 EELKTQFNDIMTVAKEKMRKVE---EIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSG 2878
E + M V + K+R+V ++ + + + + L K ELH
Sbjct: 1407 ESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDV 1466
Query: 2879 DSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWK 2938
D Q L K +L + + V + Q + M ++ +L+ +
Sbjct: 1467 DPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYN 1526
Query: 2939 QWEDSVFQTQSCLE---NLVSQMALSEQEFSGQVAQLEQALEQFS---ALLK------TW 2986
V + + LE L +M S ++ E L Q S LL +W
Sbjct: 1527 DLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISW 1586
Query: 2987 AQQ-LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED---------------LKSQL 3030
A+ L LE + D + + + ++ +EP E+ +
Sbjct: 1587 AKNVLKDLEKRKADLNTIT--ESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWC 1644
Query: 3031 NELCRFSRDLSTYSGKVSGL---IKEYNCLCLQASKGCQNKEQILQQRFRKAF------- 3080
N L L + G V+ + + + L + K +K++ + +R
Sbjct: 1645 NTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQV 1704
Query: 3081 ---RDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGEL 3137
RD L+NA+ ++++ P+ ++E++ + +K+ + + ++ +++++ L
Sbjct: 1705 ENVRDQALILMNARGSSSRELVEPK-LAELNRNFEKVSQHIKSAK-------LLIAQEPL 1756
Query: 3138 LSTLLTKEKAK-GIQ-AKVTAAKEDWKNF------HSNLHQKESALENLKIQMKDF---- 3185
L+T E + G+ + + + D +N H ++ ++ Q+++
Sbjct: 1757 YQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRG 1816
Query: 3186 -EVSAEPIQDWLSKTEK------MVHESSNRLYDLPAKRREQQKLQS------------- 3225
E+ +P++D +K EK ++H N++ +P ++R+ +L S
Sbjct: 1817 EEMLHQPMED--NKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLV 1874
Query: 3226 ------------------------VLEEIHCYEPQLNRLKEKAQQLWEGQAA-------- 3253
+ E+ E L +K++ +L E A
Sbjct: 1875 EINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV 1934
Query: 3254 --------SKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTD 3305
+ R ++QL++++ ++ + ++ DR + E QF + +L W+T+
Sbjct: 1935 ILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITE 1994
Query: 3306 AIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPT 3365
A +L C P + +R + E + + + + G+ ++Q S
Sbjct: 1995 AEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQP-SFAALNRTGDGIVQKLSQADGSF 2053
Query: 3366 IQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSME-----ANLN 3420
++++L + W ++++ + +L+G + Y+ + + W+ E +
Sbjct: 2054 LKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTT 2113
Query: 3421 ESERQHAELRDKTTML----GKAKLLNE---EVLSYSSL-----------LETIEVKGAG 3462
E ELRD T + K K LN E+LS SL L T+ +
Sbjct: 2114 ELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNK 2173
Query: 3463 MTEHYVTQLELQDLQERYRAIQER---------------AKEAVTKSEKL--VRLHQEYQ 3505
+ T L+ + +QE Q R A + +S + + + +
Sbjct: 2174 ICREVPTTLK-ECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLD 2232
Query: 3506 RDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVL----H 3561
+ + WL + L V GD T+ ++ + + L+ V +
Sbjct: 2233 KTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQN 2292
Query: 3562 TREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWL 3621
+ S + A LE ++ W QH + + Q +++ + ++ +E +
Sbjct: 2293 LKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELM 2352
Query: 3622 KTAEEKKW----------HEEVTAYRDEVEEVGAR----------AQEILDESHVNSRMG 3661
+ E + + ++++ + ++E+G Q++L+E +
Sbjct: 2353 RKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRN 2412
Query: 3662 CQAT--QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWY--GSTHKNFKNVA 3717
+ T L + + L + ++ LE E ++++ S L ++ W T N A
Sbjct: 2413 VKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDA 2472
Query: 3718 TKIDKV--DTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEI 3775
+ + D+++ + + ++ + +++ + + KS ++ VK L E + +
Sbjct: 2473 SHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHR 2532
Query: 3776 HDHMEQ----LKELTSTVR-----------KEHMTLE--------KGLHLAKEFS----- 3807
D M Q LK ++++R + M+LE K L K+
Sbjct: 2533 LDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDV 2592
Query: 3808 -------DKCKALTQWIAEYQ----------------EILHVPEEPKMELYEKKAQLSKY 3844
D CKAL + + E + + + PEEP+ L + K +L+
Sbjct: 2593 PALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNL-QSKTELTPE 2651
Query: 3845 KSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAG 3904
+ Q+ + V+EK E+L + + + ++D+ +DL + ++
Sbjct: 2652 ERAQKIAKAMRKQSSEVKEKWESLNAVTSN--WQKQVDKALEKLRDLQGAMDDLDADMKE 2709
Query: 3905 FEDRLNNLQMKGDTLIGQCADHLQAKLK-----QNVHAHLQGTKDSYSAICSTAQRMYQS 3959
E N + GD LI DH++ + ++ ++ D S +
Sbjct: 2710 AESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLK 2769
Query: 3960 LEHELQK--------HVSRQDTLQQCQA----WLSAVQPDLEPSPQPPLSRAEAIKQVKH 4007
+ +L VS D L+Q Q + + Q L S Q P R+ + +V +
Sbjct: 2770 MSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPY 2829
Query: 4008 FRALQEQARTY-----LDLLCSMCDLSNA--SVKTTAKDIQQTEQTIEQKLVQAQNLTQG 4060
+ Q Q + +L S+ DL+N S TA I++ ++ + L++ +
Sbjct: 2830 YINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEI 2889
Query: 4061 WEEIK 4065
+++ K
Sbjct: 2890 FKQHK 2894
Score = 122 bits (306), Expect = 2e-26
Identities = 497/2771 (17%), Positives = 1028/2771 (37%), Gaps = 379/2771 (13%)
Query: 1240 DCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDV 1299
D Y+ ++ L L+S QEQ + D E E + H+ ++A + V
Sbjct: 310 DLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVE---EVKDQFATHEAFMMELTAHQSSV 366
Query: 1300 QQQIAQAQQ--GEGGLPDRGHEELRKLESTLDGL-----ERSRERQERRIQVTLRKWERF 1352
+ Q +G L D E+++ + L+ S +RQ R V +
Sbjct: 367 GSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLM------ 420
Query: 1353 ETNKETVVRYLFQTGSSHERFLSFSS------LESLSSELEQTKEFSKRTESIAVQAENL 1406
E K+ + + + ER + ++SL LE+ K E+ V+ +L
Sbjct: 421 ELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSL 480
Query: 1407 VKEASEIP--LGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1464
+ G +L+ Q + + E+ + EE ++ + W
Sbjct: 481 THMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCL 540
Query: 1465 LSVWITEKEKELNALETSS----SAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQF 1520
L W+TEKE+ LN ++TS+ + + + ++ + +++E K ++ L E Q Q
Sbjct: 541 LKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQL 600
Query: 1521 VTTGESARI----KAKLTQ-----IRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKI 1571
+ ++++ +LTQ ++R + + Q + + + Q+ E +
Sbjct: 601 LDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVRE 660
Query: 1572 QQSVSEFEDKLAVP----------------------------IKICSSATETYKVLQEHM 1603
Q + + +L P I +A +T ++ +E+M
Sbjct: 661 QAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEI-KEYM 719
Query: 1604 DLCQALESLSSAITAFSASARKVVNR-DSCVQEAAALQQQYEDILRRAKERQTALENLLA 1662
+ Q + + A R+ + R D Q L +Q +E + LE + +
Sbjct: 720 KM-QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSS 778
Query: 1663 HWQ-------------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQAL 1709
W+ +L+++++++ L+ E + E + + E Q + +L
Sbjct: 779 EWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSIS-ESSRQSLPSL 837
Query: 1710 ----QNEVVSQASFYSKLLQLKESLFSVASKDDVK-MMKLHLEQLDERWRDLPQIINKRI 1764
Q E+ + + K+ + S ++ S+ ++ + R++ + + + R
Sbjct: 838 KDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQ 897
Query: 1765 NFLQSVVAE---HQQFDEL-------------------LLSFSVWIKLFLSELQTTSEIS 1802
L++ + H + L +L+ ++ L E +T EI
Sbjct: 898 QHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEI- 956
Query: 1803 IMDHQVALTRHKDHAAEVESK---------KGELQSLQGHLAKLGSLGRAEDLHLLQGKA 1853
+ + + AL + + +E K E +QG KL L ++DLHLL+ A
Sbjct: 957 LENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLV-SKDLHLLEEIA 1015
Query: 1854 EDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIE 1913
+ FE S V+E+ + + +FL + G L++ ++ ++ NE + IE
Sbjct: 1016 LT-LRAFEADSTVIEKW---MDGVKDFLMKQQAAQGDDAGLQRQLDQCSAF-VNEIETIE 1070
Query: 1914 KDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLL 1973
L + + L S V+ GI K ++G + + ++L E+ ++ L
Sbjct: 1071 SSLKNMKEIETNLRSGPVA--GI--KTWVQTRLGDYQTQL------EKLSKEIATQKSRL 1120
Query: 1974 GTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLED 2033
Q +A A LKK + +E + ++ E+ ER + + E A+++ R ++
Sbjct: 1121 SESQEKA---ANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRA----KE 1173
Query: 2034 ELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLID 2093
++ E + LKD K +A K + E+ E+N V ++ + L + +G+C L +
Sbjct: 1174 DVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELN---VVLENYQLLCNRIRGKCHTLEE 1230
Query: 2094 L------MREYQNLKSAVSKVLENA--SSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYK 2145
+ + Y +L++ LE S+ ++ T E L E+ ++ + +
Sbjct: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEAL-------ESLESVLRHP 1283
Query: 2146 QKDLDNFTSKGKHLLS----------ELKKIHS--SDFSLVKTDMESTVDKWLDVSEKLE 2193
+ G+ L+ +L+ +S D S + + +++K L V + +
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETD 1343
Query: 2194 ENMDRLRVSLSIWDDVLST--RDEIEGWSNNCVPQMAENI-SNLDNH-LRAEELLKEFES 2249
+ + L+ SL D L+T D I+ + VPQ A+ I + + H L EEL + S
Sbjct: 1344 QMLQVLQESLGELDKQLTTYLTDRIDAFQ---VPQEAQKIQAEISAHELTLEELRRNMRS 1400
Query: 2250 E-VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKD 2308
+ + + R S+++ L+ + + T L A+ Q++ K + + K L
Sbjct: 1401 QPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHV 1460
Query: 2309 FTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEALKKVKDIQKELQSQQS-NISSTQ 2367
+ + I T K + L E +K + +Q QQ+ N
Sbjct: 1461 LDVKDVDPDV----IQTHLDKCMK-LYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMD 1515
Query: 2368 ENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQE 2427
E L SL Y+ LG +T + E SQL K + + E
Sbjct: 1516 EQLTSLKVLYND-----LGAQVTEGKQDLERASQLARKMK------------KEAASLSE 1558
Query: 2428 WFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQ 2487
W + + S G L+ ++ +N+L + ++ L+ +T+ L +L +
Sbjct: 1559 WLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQ-NLIEG 1617
Query: 2488 IVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNT 2547
++E++ N + L + ++L F+ ++ W+++ E
Sbjct: 1618 SEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEAL--- 1674
Query: 2548 ENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQ 2607
L E ++ K+ E+ V+ + EL A ++ + + +L G+ + +
Sbjct: 1675 --LDEIEKKPTSKQEEI--VKRLVSELDDANLQVENVRDQALILMN-ARGSSSRELVEPK 1729
Query: 2608 LLTSHQNL-----------LRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLAC 2656
L ++N L + +E L C V + E + I++ L
Sbjct: 1730 LAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFET-GVPFSDLEKLENDIENMLKF 1788
Query: 2657 AESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRV----IQT 2712
E L S D EK + I + GE L+ Q + + KE R+ + T
Sbjct: 1789 VEKHLESSDEDEKMDEESAQIEEVLQRGEEMLH-------QPMEDNKKEKIRLQLLLLHT 1841
Query: 2713 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2772
+ +K + A S++ DY+ N++ M+ V+ + P +
Sbjct: 1842 RYNKIKAIPIQQRKMGQLASGIRSSLLP--TDYLVEINKILLCMDDVELSLNVP-ELNTA 1898
Query: 2773 LKEKFVLL-DHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDI 2831
+ E F D L++I + L +L + ++EK D + + E + Q D
Sbjct: 1899 IYEDFSFQEDSLKNIKDQ-------LDKLGEQIAVIHEKQPDVILEASGPEAI--QIRDT 1949
Query: 2832 MTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRW----SDMSGDSSATQKKL 2887
+T K ++ + D D E H +L +W ++ D+ A L
Sbjct: 1950 LTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSL 2009
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQT 2947
K I +E+ S S A N T G + +AD ++ +
Sbjct: 2010 DLEKARIHQQELEVGISSHQPSFAA---LNRTGDGIV-----QKLSQADGSFLKEKLAGL 2061
Query: 2948 QSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWH 3007
+ +V+++ + G+ Q+ + Q ++ W LT E E
Sbjct: 2062 NQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEII-CW---LTKAEHAMQKRSTTELGE 2117
Query: 3008 KGQEILDALQKAEPRTEDLK----SQLNELCRFSRDLSTYSGKVSGLIKE----YNCLCL 3059
QE+ D Q+ E E LK ++L L S L K+S ++ +N +C
Sbjct: 2118 NLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERD-KISESLRTVNMTWNKICR 2176
Query: 3060 QAS---KGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKC-----------FDIPQNIS 3105
+ K C + + Q A + Q+ ++ + + D+ + I+
Sbjct: 2177 EVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTIT 2236
Query: 3106 EVSTSLQKIQEFLSES--------ENGQHKLNMMLSKGEL---------LSTLLTKEKAK 3148
E++ L I + L + E + M ++K +L + TL K K
Sbjct: 2237 ELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNK 2296
Query: 3149 GIQAKV-TAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESS 3207
+ + TA E + + + +E + Q++D + + D +TE+++ +
Sbjct: 2297 ASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYE 2356
Query: 3208 NRLYDLPAKRREQ-----QKLQSVLEEIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHR 3260
RLY L RR+ Q +L+E+ + + Q+L E G +++ +
Sbjct: 2357 ARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKET 2416
Query: 3261 VSQLSSQYLALSNLTKEKVSRLDR----IVAEHNQFSLGIKELQDWMTDAIHMLDSYCHP 3316
L + ++ L ++ + L+ + A +K +Q+ T ++D+
Sbjct: 2417 TEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRE 2476
Query: 3317 TSDKSVLDSRTLKLEAL---LSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSV 3373
+ + + +R LK + + +I + R + V + E +Q +L +
Sbjct: 2477 NALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDM 2536
Query: 3374 KDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKT 3433
W L + ++ LE + KW + + W++ + L + ++
Sbjct: 2537 NQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQ 2596
Query: 3434 TMLGKAKLLNEEVLSYS-SLLETIEVKGAGMTEHYVTQLE--LQDLQERYRAIQERAKEA 3490
K L E+ S+L ++ + + + E ++LQ + E +
Sbjct: 2597 LQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQK 2656
Query: 3491 VTKS--EKLVRLHQEYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVH 3548
+ K+ ++ + ++++ W Q + L++ L+G + +++ + ++
Sbjct: 2657 IAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNG 2716
Query: 3549 CAE-GQALLNS-------VLHTREDVIPSGI------------------PQAE-DRALES 3581
G L++S ++ RE++ P P + R L+
Sbjct: 2717 WKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDD 2776
Query: 3582 LRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVD---EWLKTAEEKKW-----HEEV 3633
L W+ Q + + Q Q F W ++ K H+
Sbjct: 2777 LNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYINHQTQ 2836
Query: 3634 TAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLE------- 3686
T D ++ Q + D ++V A ++ +AL L +LE E
Sbjct: 2837 TTCWDH-PKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQHKL 2895
Query: 3687 ---EEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDK--------VDTVMMGK-KLKT 3734
+++ S+ + + L++ D HK+ NV +D DT GK ++++
Sbjct: 2896 NQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIRVQS 2955
Query: 3735 LEVLLKDMEKG 3745
L++ L + KG
Sbjct: 2956 LKIGLMSLSKG 2966
Score = 114 bits (286), Expect = 3e-24
Identities = 483/2746 (17%), Positives = 1047/2746 (38%), Gaps = 487/2746 (17%)
Query: 6164 KELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKP-DVLSQELGMEGEKS---S 6219
++ ++E E+ ++S A E + AET E D+ S ++ +E + S
Sbjct: 271 RKYKKECEEEAINIQSTAPEEEH---ESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLS 327
Query: 6220 AEDQMRMK------WESLHQEFSTKQKLLQNVL-EQEQEQVLYSRPNRLLSGVPLYKGDV 6272
AED + + E + +F+T + + + Q + N+L++ +G +
Sbjct: 328 AEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLIT-----QGTL 382
Query: 6273 PTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQS------IHLEQKLYDGVSATSTWLDDV 6326
+++ + + LN +E + +S RQS + L++K +SA WL
Sbjct: 383 SDEEEFEIQEQMTLLNARWEALRVES--MDRQSRLHDVLMELQKKQLQQLSA---WLTLT 437
Query: 6327 EERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPE----NGDNRDV 6382
EER+ ++ ETC + D+K + + ++++K+L S E N V
Sbjct: 438 EERI--------QKMETCPLDD-----DVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMV 484
Query: 6383 I-------EDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYI 6435
+ E L +L L C +ER ++ ++ +L+ L + + +
Sbjct: 485 VIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRL----QEINILWQELLEEQCL 540
Query: 6436 ILQKLANVFEQPVAEQIEAIQQAEDG----LKEFDAGIIELKRRGDKLQVEQPSMQELSK 6491
+ L E+ EA+ + + KE + L + +++++ ++ +LS+
Sbjct: 541 LKAWLT--------EKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE 592
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ +L+ + + + + L +++ +Q L D + +A + K+
Sbjct: 593 IGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDL 652
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
++ + + + + + + ++ I ++ + +F + +LK K +
Sbjct: 653 LETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILK--WKTAI 710
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESS----IPSVGLVEENEDRLIDRITLYQHLKSS 6667
+ I E +D E+ ++L+ +E IP + + L++++ K
Sbjct: 711 QTTEIKEYMKM--QDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG-----KEG 763
Query: 6668 L--NEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILK- 6724
L E + L +V + K +S DLE ++ QL E + N K+L LE ++K
Sbjct: 764 LPTEEIKNVLEKVSSEWKN--VSQHLEDLERKI-QLQE----DINAYFKQLDELEKVIKT 816
Query: 6725 --HWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQS 6782
W ++ S S L S KD + + + ++EM R +A + D
Sbjct: 817 KEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQ 876
Query: 6783 SLKSSVLSTGNQLLRLKKVDTATLRSELS-RIDSQWTDLLTNIPAV---QEKLHQLQMDK 6838
S L + + L +EL + + + L + V E Q+ ++
Sbjct: 877 RGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNV 936
Query: 6839 LPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDF 6898
L + + + ++ +++ + A+H+ ++ K + +++
Sbjct: 937 LNDLAKVEKALQEKKTLDEILENQKP---------ALHKLAEETKALEKNVH-------- 979
Query: 6899 VNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYEN 6958
DVE + K +F + G NK L+ LV++ + LLE + + +E
Sbjct: 980 ----------PDVE--KLYKQEFDDVQGKWNK----LKVLVSKDLHLLEEIALTLRAFEA 1023
Query: 6959 NVQCLKTWFE-TQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLAL 7017
+ ++ W + ++ +KQQ GD A +Q L C + I+ E ++ +++ L
Sbjct: 1024 DSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNL 1083
Query: 7018 IQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLME 7077
+ + V + L + L + K L ++ ++ K ++ ++ +
Sbjct: 1084 RSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQ 1143
Query: 7078 ARYSLSRFRLLTGSLEAVQVQVDNLQNLQDD-LEKQERS--------------------- 7115
A S E ++ V+ ++ ++D L+K+ R
Sbjct: 1144 AEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQEL 1203
Query: 7116 -------LQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLE----------EIAE 7158
L+ + + N++ +CH TL+EV W LL + E
Sbjct: 1204 TSELNVVLENYQLLCNRIRGKCH---------TLEEVWSCWIELLHYLDLETTWLNTLEE 1254
Query: 7159 QLQSSKALLQLWQRYKDYSKQCASTVQQQED---RTNELLKAATNKDIADDEVATWIQDC 7215
+++S++ L + + + S ++ D + EL + + I DD ++ ++
Sbjct: 1255 RMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAF 1314
Query: 7216 NDLLKGLG--------TVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALE- 7266
N + L +++ L L E +Q+ Q + S + L+ + A +
Sbjct: 1315 NSRYEDLSHLAESKQISLEKQLQVLRET-DQMLQVLQESLGELDKQLTTYLTDRIDAFQV 1373
Query: 7267 -QALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAE--------EILQGQDPSHSSDLST 7317
Q K Q + A L E +++ + E+ ++LQ + S+
Sbjct: 1374 PQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQL 1433
Query: 7318 IQ------ERMEELKG---------QMLKFSSMAPD-----LDRLNELGYRLPLNDKEIK 7357
Q +RM + K +L + PD LD+ +L L E++
Sbjct: 1434 FQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVE 1493
Query: 7358 RMQNLNRHWSLISSQTTER--------------FSKLQSFLLQHQTFLEKCETWMEFLVQ 7403
+ RH ++ Q T+ ++ L + + + + LE+ + +
Sbjct: 1494 TVIKTGRH--IVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKK 1551
Query: 7404 TEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFN 7463
L+ +S L+++ + L ++ + +++ D LE+ + D +
Sbjct: 1552 EAASLSEWLSATETELVQKSTSEGLL-GDLDTEISWAKNVLKD----LEKRKAD-LNTIT 1605
Query: 7464 LKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVE-VSYLPM--SGLG 7520
L N +G ++R ++++ W R R E L+ + L + +
Sbjct: 1606 ESSAALQNLIEGSEPILEERLCVLNAG---WSRVRTWTEDWCNTLMNHQNQLEIFDGNVA 1662
Query: 7521 SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAE----L 7576
+ L QA L DE++ +K +Q+ E K+L+ D +A LQ E
Sbjct: 1663 HISTWLYQAEALLDEIE--KKPTSKQE-------EIVKRLVSELD---DANLQVENVRDQ 1710
Query: 7577 AEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHE-E 7635
A I + +S R E + KLA L +++EK + I + KL ++ L Q L E
Sbjct: 1711 ALILMNARGSSSR-ELVEPKLAELNRNFEKVSQHIKSA--KLLIAQEPLYQCLVTTETFE 1767
Query: 7636 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNE---RVELLQRQWEE 7692
++LEN + + +LK S+D+ ++E ++E + ++ EE
Sbjct: 1768 TGVPFSDLEKLENDIEN---------MLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEE 1818
Query: 7693 LCHQ---------LSLRRQQIGERLNEWAVFSEKNKEL-------------CEWLTQMES 7730
+ HQ + L+ + R N+ + +++ ++L ++
Sbjct: 1819 MLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINK 1878
Query: 7731 KVSQNGDILIEEMIEKLKKDYQEEIAIAQEN----KIQLQQMGERLAKASHESK------ 7780
+ D+ + + +L E+ + +++ K QL ++GE++A HE +
Sbjct: 1879 ILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIA-VIHEKQPDVILE 1937
Query: 7781 -----ASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIES 7835
A +I L ++N +W + + + R + +Q +++ L W+ E
Sbjct: 1938 ASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEE 1997
Query: 7836 ELAKPIVYDSC---NSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATD 7892
++ D+C S ++++ QQEL+ I H A++ + ++ +
Sbjct: 1998 -----LLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKL----SQ 2048
Query: 7893 AECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAA 7952
A+ +++ L++RW I A +R+ +++ + K+ WL +E
Sbjct: 2049 ADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQ 2108
Query: 7953 FPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSL----- 8007
S+ T E L++ +++ +L+ +N R E +D + SL
Sbjct: 2109 KRST-----TELGENLQELRDLTQEMEVHAEKLKWLN----RTELEMLSDKSLSLPERDK 2159
Query: 8008 -KQMVHEGNQRWDNLQKRVTSILRRL-------------KHFIGQREEFETARDSILV-- 8051
+ + N W+ + + V + L+ H Q+ ++ I V
Sbjct: 2160 ISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQS 2219
Query: 8052 ---------------------WLTEMDLQL-TNIEHFSECD-VQAKIKQLKAFQQEISLN 8088
WL +D L +NI + + + + ++K + ++
Sbjct: 2220 HRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQR 2279
Query: 8089 HNKIEQIIAQGEQLIEKSEPLDA-AIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPD- 8146
H +++ + + L K+ D I E+L+ ++ VE ++L + +
Sbjct: 2280 HPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSL 2339
Query: 8147 --DEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL---------------S 8189
D+H EL + A L L R L+ Q S N L +
Sbjct: 2340 QWDDHREETEELMRKYEARLYILQQARRDP---LTKQISDNQILLQELGPGDGIVMAFDN 2396
Query: 8190 LAQPLRSERSGRDT---PASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFY 8246
+ Q L E DT + + + W + D ++A+ + +D ++F
Sbjct: 2397 VLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFL 2456
Query: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNTSGDHSALESQI--RQLGKALDDSRFQIQQT 8304
I E+ + T N + + S +AL+ I R+L + + D + +I
Sbjct: 2457 K---------WIQEA-----ETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAH 2502
Query: 8305 ENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET 8364
+I +S +D + + +K LG + L+H+L + +
Sbjct: 2503 NDIFKS-------IDGNRQKMVKALGNS----EEATMLQHRLDDMNQ------------- 2538
Query: 8365 QTAGVIDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELS 8424
RW L+A++ S ++ + +KW + L + WL +EEL+ +++ +
Sbjct: 2539 -------RWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELK--KQMPIG 2589
Query: 8425 TDIQTIELQIKKLKELQK-----------AVDHRKAIILSINLCSPEFTQAD-------- 8465
D+ ++LQ K L++ AVD + + + +PE + +
Sbjct: 2590 GDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELT 2649
Query: 8466 -----SKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLEN 8520
K ++ ++ + S++ +W+ + ++ W+ + AL + + L ++
Sbjct: 2650 PEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE 2709
Query: 8521 IDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC 8580
+ +N P+ +L + LQDH +++M + E+ +V ++ D+S Q L +
Sbjct: 2710 AESVRNGWKPV-GDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQ-LSPLDLHPS 2767
Query: 8581 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKL-LDVSSSQQDLSSWS 8625
L+ ++ + R KLL V +K+L++ D S Q S S
Sbjct: 2768 LKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTS 2813
Score = 108 bits (269), Expect = 3e-22
Identities = 397/2103 (18%), Positives = 810/2103 (38%), Gaps = 297/2103 (14%)
Query: 3761 KYLEEGEAERLRKEI----HDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQW 3816
KY +E E E + + +H E STV + M L+ + + + W
Sbjct: 272 KYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDS-------YQIALEEVLTW 324
Query: 3817 IAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVT 3876
+ ++ ++ ++ E K Q + +++ + +H+ SV SV + G +L+ T
Sbjct: 325 LLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGN---QLITQGT 381
Query: 3877 LKDKID-QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNV 3935
L D+ + ++Q L + +A+ E + RL+++ M+ LQ K Q +
Sbjct: 382 LSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLME-----------LQKKQLQQL 430
Query: 3936 HAHLQGTKDSYSAI--CSTAQRMYQSLEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQ 3993
A L T++ + C + +SL+ L++H S Q L+ Q ++++ + +
Sbjct: 431 SAWLTLTEERIQKMETCPLDDDV-KSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDE 489
Query: 3994 PPLSRAEAIKQ-----------------VKHFRALQEQARTYLDLLCSMCDLSN-ASVKT 4035
A AI + + + LQE + +LL C L + K
Sbjct: 490 NSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKE 549
Query: 4036 TAKDIQQTEQTIEQKLVQAQ-----NLTQGWEEIKHLKSELWIYLQDADQQLQN---MKR 4087
A + QT +QK + L + E + +L QD Q L N K+
Sbjct: 550 EALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKK 609
Query: 4088 RHSELE---------LNIAQNMVSQVKDFVKKLQSKQASVNTIIEKV----NKLTKKEES 4134
+S+ E + ++ +QV V KL Q ++E V +TKK +
Sbjct: 610 INSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQ 669
Query: 4135 -------PEHKEIN---HLNDQWLDLCRQSNNLCLQREEDLQRT--RDYHDCMNVVEV-- 4180
P+ ++I+ ++ + + N L+ + +Q T ++Y + E+
Sbjct: 670 ELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKK 729
Query: 4181 ---FLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEHL-N 4236
LEK E A ++ + +E + K L +E K +E + + + + +HL +
Sbjct: 730 KLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLED 789
Query: 4237 LDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNI 4296
L+ K ++E + ++ +LE +IK K + ++ ++ +S Q L + Q +
Sbjct: 790 LERKIQLQEDINAYFKQLDELEKVIKTKEEW----VKHTSISESSRQSLPSLKDSCQREL 845
Query: 4297 AEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKAL 4356
L P +MA+ A CS L ++ + + D L Q +Q+A+
Sbjct: 846 TNLLGLHPKIEMAR-------ASCSALMSQPSAPDFVQRGFDSF-----LGRYQAVQEAV 893
Query: 4357 SDAQSHVNCLSDLVGQ-------RRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFRE 4409
D Q H+ ++L GQ K L L++ + + + E+ + ++
Sbjct: 894 EDRQQHLE--NELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKK 951
Query: 4410 HICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQ 4469
+ D++ + K +L E L ++++ +QE +V GK +L+
Sbjct: 952 TL----DEILENQK------PALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLK 1001
Query: 4470 SVYDSVLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHT 4529
++ K H L+E+ L + F+ D W+ + + + L
Sbjct: 1002 ----VLVSKDLHLLEEIALTL---RAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQR 1054
Query: 4530 QLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVI---VA 4586
QL + + + E+ L ++ + +++ +L Q + +A
Sbjct: 1055 QLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIA 1114
Query: 4587 LAKDKFYKVQE-AILARKEYASLIELTTQSLSE-LEAQFLRMSKVPTDLAVEEALSLQDG 4644
K + + QE A +K+ A + E TQ+ E LE F S + AVEE ++
Sbjct: 1115 TQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKED 1174
Query: 4645 CRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLED 4704
+L + + D + S GQ + + L Y L + + LE+
Sbjct: 1175 ---VLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLEN-YQLLCNRIRGKCHTLEE 1230
Query: 4705 TTSAYQE-------HEKMCQQLERQLKSVK---EEQSKVNE--ETL------PAEEKLKM 4746
S + E LE ++KS + E+ VNE E+L PA+ + ++
Sbjct: 1231 VWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQI 1290
Query: 4747 YHSLAGSLQDSGIV-------LKRVTIHLEDLAPHL---DPLAYEKARHQIQSWQGELKL 4796
L +L D GI+ L+ EDL+ HL ++ EK ++ L++
Sbjct: 1291 -RELGQTLIDGGILDDIISEKLEAFNSRYEDLS-HLAESKQISLEKQLQVLRETDQMLQV 1348
Query: 4797 LTSAIGETVTECESRMVQSID-FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRK 4855
L ++GE + + + ID FQ ++++AE+S +L L++++ +R
Sbjct: 1349 LQESLGELDKQLTTYLTDRIDAFQVPQE-----AQKIQAEISAH---ELTLEELRRNMRS 1400
Query: 4856 IQIHQEEVQSSL--RIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTR 4913
+ E +++ M+ L K +E TK + L +
Sbjct: 1401 QPLTSPESRTARGGSQMDVLQRKLREVSTKFQ------------------------LFQK 1436
Query: 4914 QATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQ 4973
A + C+R +A EL L +D + + +L M+ + T +
Sbjct: 1437 PANFEQRMLDCKRVLDGVKA---------ELHVLDVKDVDPDVIQTHLDKCMKLYKTLSE 1487
Query: 4974 FHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQV----DLLQRCT 5029
+E + + + + +++++ SL++ + D GAQV L+R +
Sbjct: 1488 VKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKV----LYNDLGAQVTEGKQDLERAS 1543
Query: 5030 AQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIV 5089
+K + E ++ TE +L + S + + ++S K ++ + +
Sbjct: 1544 QLARKMKKEAASLSEWLSATETELVQKS-TSEGLLGDLDTEISWAKNVLKDLEKRKADLN 1602
Query: 5090 ALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKV 5149
+ E ++ L+ + S+ L + + W+R+R +D L + ++ F+ V
Sbjct: 1603 TITESSAALQNL-IEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNV 1661
Query: 5150 KKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ 5209
+ + Q + L + SK E E V EL+ + +R Q L ++
Sbjct: 1662 AHISTWLYQAEALLDEIEKKPTSKQE-----EIVKRLVSELDDANLQVENVRDQALILMN 1716
Query: 5210 DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE-----------------LK 5252
+ + P + E+ ++ + + +K+ L+ QE
Sbjct: 1717 ARGSSSRELVEPKLAELNRNFEK---VSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFS 1773
Query: 5253 DREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNH-RQNIEKMAEEQK 5311
D E +E I ++ +V++ E + + D +++E + E + + + E+ K
Sbjct: 1774 DLEKLENDIENMLKFVEKHLE-----SSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNK 1828
Query: 5312 EKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKE--------VEQSK----ATSQEL 5359
++ + L +L ++ + + + Q+ I+ VE +K EL
Sbjct: 1829 KEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVEL 1888
Query: 5360 SRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQN 5419
S + +L T I + D++ K LGE++ + K ++ LE +
Sbjct: 1889 SLNVPELN---TAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDV------ILEAS 1939
Query: 5420 GQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
G + + +L + R +R ++A +++ L + +WI +A+ L
Sbjct: 1940 GPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELL 1999
Query: 5480 HGTIAWNSASQLREQYILHQTLLE--------ESKEIDSELEAMTEKLQYLTSVYCTEKM 5531
T A + L E+ +HQ LE ++ + + +KL + EK+
Sbjct: 2000 VDTCAPGGSLDL-EKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKL 2058
Query: 5532 SQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGR 5591
A L + + + +K R L+ +K + K+ +L ++ L +A+ +
Sbjct: 2059 ----AGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTE 2114
Query: 5592 LSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRL 5651
L E L + L EME K++ L ++ L + D SLP ++ E +
Sbjct: 2115 LG--ENLQELRDLTQEMEVHAEKLK--WLNRTELEMLSDKSLSLP---ERDKISESLRTV 2167
Query: 5652 QHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHE 5711
T + C + + ++ QE + Q AH ++ K V S+ ++ Q R
Sbjct: 2168 NMTWNKICREVPTTL---KECIQEPSSVSQTRIAAHPNVQ-KVVLVSSASDIPVQSHRTS 2223
Query: 5712 ELA 5714
E++
Sbjct: 2224 EIS 2226
Score = 46.6 bits (109), Expect = 0.001
Identities = 59/289 (20%), Positives = 133/289 (46%), Gaps = 32/289 (11%)
Query: 8335 SIDSVKRLE-----HKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMKQ 8389
+ID+++ +E +K + EEE+ +N+ ST + + E +A+ S +
Sbjct: 259 TIDAIREVETLPRKYKKECEEEA----INIQSTAPE-----EEHESPRAETPSTVTEVDM 309
Query: 8390 NLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKLKELQKAVDHRKA 8449
+L +Q L + WL E+ ++ ++S D++ ++ Q + + ++
Sbjct: 310 DLDSYQ---IALEEVLTWLLSAEDTFQEQD--DISDDVEEVKDQFATHEAFMMELTAHQS 364
Query: 8450 IILSI----NLCSPEFTQADSKESRDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQ 8505
+ S+ N + T +D +E ++Q++++ +N RW+ + + + L D LM+ Q
Sbjct: 365 SVGSVLQAGNQLITQGTLSDEEEF-EIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQ 423
Query: 8506 --GFHEMSHGLLLMLENIDRRKNEIVPIDSNLDA-EILQDHHKQLMQIKHELLESQLRVA 8562
++S L L E I +K E P+D ++ + + L + HK L + +L Q++V
Sbjct: 424 KKQLQQLSAWLTLTEERI--QKMETCPLDDDVKSLQKLLEEHKSL---QSDLEAEQVKVN 478
Query: 8563 SLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKL 8611
SL M + N+ + ++++ +G R + + L+++
Sbjct: 479 SLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEI 527
Score = 43.5 bits (101), Expect = 0.009
Identities = 79/396 (19%), Positives = 153/396 (38%), Gaps = 74/396 (18%)
Query: 8324 GYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHS---------TETQTAGVIDRWE 8374
G + L +CS+ ++ ++ +E LK +E NL S +T+ + E
Sbjct: 1051 GLQRQLDQCSAFVNEIETIESSLKNMKEIE---TNLRSGPVAGIKTWVQTRLGDYQTQLE 1107
Query: 8375 LLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEE-LEQLQRLELSTDIQTIELQ 8433
L + +++ R+ ++ +K DL + W+ EEE LE+ + ++++ +
Sbjct: 1108 KLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEE 1167
Query: 8434 IKKLKE--LQKAV------DHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+K+ KE LQK V D+ K + + E T + + Q +++ G+
Sbjct: 1168 MKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGK--- 1224
Query: 8486 VCSLLEE-----------------WRGLLQDALMQCQGFHEMSHGLLLMLENIDR----- 8523
C LEE W L++ + + E + + LE+++
Sbjct: 1225 -CHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHP 1283
Query: 8524 --RKNEIVPIDSNL-DAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLVNAEGTDC 8580
+ +I + L D IL D ++ K E S+ S S Q+ + +
Sbjct: 1284 ADNRTQIRELGQTLIDGGILDD----IISEKLEAFNSRYEDLSHLAESKQISLEKQLQVL 1339
Query: 8581 LEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADELDTSGSVSPTS 8640
E + + V+ L L K+++ ++ + V Q + + SA EL T
Sbjct: 1340 RETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHEL--------TL 1391
Query: 8641 GRSTPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGS 8676
N + P ++SP SR+ +GGS
Sbjct: 1392 EELRRNMRSQP------------LTSPESRTARGGS 1415
>gi|145580592 nesprin-3 [Homo sapiens]
Length = 975
Score = 285 bits (729), Expect = 1e-75
Identities = 193/751 (25%), Positives = 370/751 (49%), Gaps = 15/751 (1%)
Query: 2631 QEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNM 2690
Q + + +++ W+KA+QD+L ++T G + LE RL + + I ++ EG V++++
Sbjct: 4 QPQDDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDL 63
Query: 2691 AIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKN 2750
+ E L + + I +L+ +K W + ++ H S +E V W++Y+ ++
Sbjct: 64 VLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARD 123
Query: 2751 QLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEK 2810
+ +W + + +E ++ Q GLKEK L H Q +L ++ L RL+ ++ L+ +
Sbjct: 124 EFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
Query: 2811 TEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEEL 2870
D S + AQ+ +K +++ + A++++ +E++ ++H Y V EF WL + E++
Sbjct: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
Query: 2871 HRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEM 2930
+ + TQ +LS ++++ G L +E + V +NT+ G E + E+
Sbjct: 244 NGCLGRNCKLPITQ-RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGEL 302
Query: 2931 QALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQ- 2989
+ +R ++ + + L L+ EQ Q+ QLE L +F +L+ AQ+
Sbjct: 303 EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQ----QIKQLEAELSEFRMVLQRLAQEG 358
Query: 2990 LTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSG 3049
L T++E+V W + AL EPR + L++QL EL F +L S V
Sbjct: 359 LQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIA 418
Query: 3050 LIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVST 3109
I+EY L +++++ L Q F++ +D Q W A+ +P ++ + T
Sbjct: 419 TIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLP-DLPSLHT 477
Query: 3110 SLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLH 3169
L +I+ L ES + L M+ K +LL + +E+A + +V + D H++L
Sbjct: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLL 537
Query: 3170 QKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEE 3229
Q++S L++L Q KDF + EP+Q L + V DLP K+ + +LQ + EE
Sbjct: 538 QRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
Query: 3230 IHCYEPQLNRLKEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEH 3289
Q+ + Q+ + + +H++ QLSS + AL ++ V R + V EH
Sbjct: 598 GLDLGAQMEAARPLVQE-------NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEH 650
Query: 3290 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3349
FS + EL+ W+ L+++ + +S+ + E L++ EKE Q+ ++
Sbjct: 651 CTFSHQLLELRQWIVVTTQKLEAH-RGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEA 709
Query: 3350 RGESVLQNTSPEGIPTIQQQLQSVKDMWASL 3380
+G V++ +SPEG +Q++L+ + + W +L
Sbjct: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRAL 740
Score = 105 bits (262), Expect = 2e-21
Identities = 128/640 (20%), Positives = 257/640 (40%), Gaps = 52/640 (8%)
Query: 3290 NQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVT 3349
+ F +++ Q WM L + ++ L++R + E + ++ E +++ +++
Sbjct: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
Query: 3350 RGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFS 3409
E++L + P I +L+ +K W ++ C S++E W+ Y +F
Sbjct: 67 MAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFY 126
Query: 3410 GWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVT 3469
W M L L++K L A++L V + + LL+ + + A +
Sbjct: 127 RWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGD 186
Query: 3470 QLELQDLQER----YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY 3525
+D Q+R Y A++ +A++ V E++ R H+EYQ + F++WL EK++
Sbjct: 187 PSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVN-- 244
Query: 3526 SVLEGDAHTHET-TLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAED-------- 3576
L + T L LQ++ G+ L ++ VI + P +
Sbjct: 245 GCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEE 304
Query: 3577 --RALESLRQDWQAYQHRLS---ETRTQFNNVVNKLRLMEQKFQQV-----DEWLKTAEE 3626
+ LE LR W+ + RL +R + + +L +F+ V E L+ A +
Sbjct: 305 MRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAK 364
Query: 3627 KKWHEEVTAY--------------RDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQ 3672
+E+ A+ V+ + A+ +E++ H + YQ
Sbjct: 365 AGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQ 424
Query: 3673 ALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKL 3732
+L ++ E+ + + L W + + A+ D + L
Sbjct: 425 SLKVKSARLRNAAAVEL--WQHFQRPLQDLQLWKALAQRLLEVTAS---LPDLPSLHTFL 479
Query: 3733 KTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKE 3792
+E L + + LL + K + + + A L +++ M L +++ +
Sbjct: 480 PQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQR 539
Query: 3793 HMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVL 3852
L+ L K+F + L + + + Q + + + +L K+AQLS+ + LQ+ L
Sbjct: 540 KSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGL 599
Query: 3853 SHEPSVKSVREKGEALLELVQD-VTLKDKIDQLQSDYQDL 3891
+ + EA LVQ+ + K+DQL SD+Q L
Sbjct: 600 -------DLGAQMEAARPLVQENPNHQHKMDQLSSDFQAL 632
Score = 72.4 bits (176), Expect = 2e-11
Identities = 103/382 (26%), Positives = 157/382 (41%), Gaps = 49/382 (12%)
Query: 8379 QALSKEL-----RMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8433
QAL + L R +Q++Q+ F+ L + W+ T ++LE + D ++ E +
Sbjct: 630 QALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAE 689
Query: 8434 IKKL------KELQKAVDHRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDRVC 8487
++L KE Q ++ + ++ + SPE +E R+L + + + +
Sbjct: 690 FERLVAEFPEKEAQLSLVEAQGWLV-MEKSSPEGAAVVQEELRELAESWRALRLLEESLL 748
Query: 8488 SLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQL 8547
SL+ W Q S ++ NI + I P+D + H ++
Sbjct: 749 SLIRNWH---------LQRMEVDSGKKMVFTNNIPKSGFLINPMDP------IPRHRRRA 793
Query: 8548 MQIKHELLESQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKE 8607
++ E S +D S QLL N +E + V +I R +R K
Sbjct: 794 NLLQEE-------EGSHEDFS-QLLRNFGQWLQVENSKLVRIIAMRTSTAEDLRTRKSKL 845
Query: 8608 LEKLLDVSSSQQDLSSWSSADELDTSGSVSPTSGRSTPNRQKTPRGKCSLSQPGPSVSSP 8667
E V Q + L G TS R + K L G ++
Sbjct: 846 QELEARVPEGQHLF------ENLLRLGPARGTSDELEDLRYQWMLYKSKLKDSGHLLTQ- 898
Query: 8668 HSRSTKGGSDSSLSEPGPGRSGRGFLFR-VLRAALPLQLLLLLLIGLACLVPMSEEDYSC 8726
+ G + + R G G LFR ALPLQLLLLL + L L+P+ EED SC
Sbjct: 899 ----SSPGEPTGFQKTRRWR-GLGSLFRRACCVALPLQLLLLLFLLLLFLLPIREEDRSC 953
Query: 8727 ALSNNFARSFHPMLRYTNGPPP 8748
L+NNFARSF MLRY NGPPP
Sbjct: 954 TLANNFARSFTLMLRY-NGPPP 974
Score = 71.2 bits (173), Expect = 4e-11
Identities = 175/953 (18%), Positives = 364/953 (38%), Gaps = 152/953 (15%)
Query: 3503 EYQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHT 3562
++ R ++ + W+ Q++L +G E L + +++ EG+ ++ VL
Sbjct: 8 DFDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRM 67
Query: 3563 REDVI---PSGIPQAEDRALESLRQDWQ------AYQHRLSE-----------TRTQFNN 3602
E ++ P L+ ++ W+ + H E R +F
Sbjct: 68 AEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR 127
Query: 3603 VVNKLRLMEQKFQQVDEWLKTAEEKKW---HEEVTAYRDEVEEVGARAQEILDES-HVNS 3658
K+ + + ++ LK EK+W H +V + V+ +L+E+ + +
Sbjct: 128 WFQKMMVTLEPHIELQLGLK---EKQWQLSHAQVLLHN--VDNQAVLLDRLLEEAASLFN 182
Query: 3659 RMGCQAT------QLTSRYQALLLQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKN 3712
R+G + ++ + Y A+ + +++ LE+ + EE ++ + + W + +
Sbjct: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEK 242
Query: 3713 FKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLR 3772
+ K+ ++L TL+ + KD +G L++ E+ ++ AE++
Sbjct: 243 VNGCLGRNCKLPIT---QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
Query: 3773 KEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKM 3832
E+ + + L++L + +E L L + + K L ++E++ +L + +
Sbjct: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGL 359
Query: 3833 ELYEKK-------AQLSKYKSLQQTVLSHEP----------------------------- 3856
+ K A +Y + + + S EP
Sbjct: 360 QPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIAT 419
Query: 3857 -------SVKSVREKGEALLEL-------VQDV----TLKDKIDQLQSDYQDLCSIG--- 3895
VKS R + A +EL +QD+ L ++ ++ + DL S+
Sbjct: 420 IQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFL 479
Query: 3896 ---KAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICST 3952
+A + E + ++ L LQ+K D LIG L + V ++ ++++
Sbjct: 480 PQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQR 539
Query: 3953 AQRMYQSLEHELQKHVSRQDTLQQ----CQAWLSA---VQPDLEPSPQPPLSRAEAIKQV 4005
++ QSL + + + + LQ+ Q + A +Q DL P Q LSR + +++
Sbjct: 540 KSKL-QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDL-PGKQAQLSRLQGLQEE 597
Query: 4006 -KHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEI 4064
A E AR L + + D Q ++++E + + + Q
Sbjct: 598 GLDLGAQMEAARP----LVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTF 653
Query: 4065 KHLKSEL--WIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTII 4122
H EL WI + Q ++ E A++ ++ + V + K+A + +++
Sbjct: 654 SHQLLELRQWIVV-----TTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEAQL-SLV 707
Query: 4123 EKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFL 4182
E L ++ SPE + + ++ +L L L E L R++H + +EV
Sbjct: 708 EAQGWLVMEKSSPEGAAV--VQEELRELAESWRALRLLEESLLSLIRNWH--LQRMEVDS 763
Query: 4183 EKFTTEWDNLARSDAESTAVH-LEALKKLALALQERKYAIEDLKDQKQKMIEHLNLDDKE 4241
K +N+ +S + + ++ A LQE + + ED + + L +++ +
Sbjct: 764 GKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSK 823
Query: 4242 LVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALK 4301
LV R I + + E+L +S+ QEL E Q L+
Sbjct: 824 LV-------------------RIIAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLR 864
Query: 4302 QSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQK 4354
P + L +L + ML KS +KD+ ++ E QK
Sbjct: 865 LGPARGTSDEL--------EDLRYQWMLYKSKLKDSGHLLTQSSPGEPTGFQK 909
Score = 68.9 bits (167), Expect = 2e-10
Identities = 115/641 (17%), Positives = 250/641 (39%), Gaps = 55/641 (8%)
Query: 2126 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSEL---------KKIHSSDFSLVKT 2176
++ +W S + + ++ + LD + L + + +K +++ VK
Sbjct: 147 KEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKA 206
Query: 2177 DMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGW-SNNCVPQMAENISNLD 2235
+ VD V+ + EE + +W + + +++ G NC + + +S L
Sbjct: 207 KAQKRVDLLEQVAREHEEYQAGVD-EFQLW--LKAVVEKVNGCLGRNCKLPITQRLSTLQ 263
Query: 2236 NHL----RAEELLKEFESEVKNKALRLEELHSK--VNDLKELTKNLETPPDLQFIEADLM 2289
+ R EE L+ E + L ++ +L+E+ K LE L E + +
Sbjct: 264 DIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERL 323
Query: 2290 QKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCEAL--- 2346
+ L ++ E +K A+ ++ + + +E L A+ T + L
Sbjct: 324 RGLLRSRGAWEQQ---IKQLEAELSEFRMVLQRLA------QEGLQPAAKAGTEDELVAH 374
Query: 2347 -KKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSK 2405
++ + L S++ + Q L L H+ L+ L ++ I++++++ ++
Sbjct: 375 WRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLKVKSAR 432
Query: 2406 TQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG---DSKVLEAKLHDLQNILDS 2462
+ + L +HF +Q+ Q W KA A+ + T D L L ++ L
Sbjct: 433 LRNAAAVELWQHFQRPLQDLQLW----KALAQRLLEVTASLPDLPSLHTFLPQIEAALME 488
Query: 2463 VSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCAS 2522
S + L + + L ++ +++ EQ+ + + L+ K LQ +
Sbjct: 489 SSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLA 548
Query: 2523 ELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLD 2582
+ F L + +++ R E ++ +P K+ ++ +++ E L ++
Sbjct: 549 QHKDFGAAFEPLQRKLLDLQVRVQAEK--GLQRDLPGKQAQLSRLQGLQEEGLDLGAQME 606
Query: 2583 KLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQS 2642
Q H QL + Q L R ++ + C+ ++QEH L
Sbjct: 607 AARPLVQENPNHQH-------KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
Query: 2643 MWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSS 2702
+ W+ +L G D E + ++ + ++ E E +L++ +G + S
Sbjct: 660 LRQWIVVTTQKLEAHRGEAGPGDA-ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKS 718
Query: 2703 NKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
+ EG V+Q +L L E W + + +L S+I W+
Sbjct: 719 SPEGAAVVQEELRELAESWRALRL----LEESLLSLIRNWH 755
Score = 65.1 bits (157), Expect = 3e-09
Identities = 163/863 (18%), Positives = 327/863 (37%), Gaps = 97/863 (11%)
Query: 6808 SELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNIK 6867
+ L I +QW + +T + ++ + + A E W M + E +I+
Sbjct: 85 ARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTL---EPHIE 141
Query: 6868 NSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGA 6927
+G K L + +++ + + +D + + + + + D + +
Sbjct: 142 LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-----RIGDPSVDEDAQKR 196
Query: 6928 MNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQ 6987
M + ++ +++ LLE + EY+ V + W + +++ + +
Sbjct: 197 MKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPIT 256
Query: 6988 NALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELGQTWANLDHMV 7047
L QD+ E+ +E +E+ +I+N + + L E+ + L +
Sbjct: 257 QRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALW 316
Query: 7048 GQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRF-------RLLTGSLEAVQVQVD 7100
+ + L+ +L + + ++ + L E R L R G+ + +
Sbjct: 317 EEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWR 376
Query: 7101 NLQNLQDDLEKQERSLQKFGSITNQLLKECH--PPVTETLTNTLKE--------VNMRWN 7150
+ L +E + + + +L+ H P+++++ T++E +R N
Sbjct: 377 RYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKVKSARLR-N 435
Query: 7151 NLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL--LKAATNKDIADDEV 7208
E+ + Q LQLW+ + +++ L ++AA + E+
Sbjct: 436 AAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKEL 495
Query: 7209 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7268
T +Q DLL G+ F E L +QV A +++ L L +
Sbjct: 496 LTMLQLKKDLLIGI--------FGQERATALLEQV----AGSMRDRDL--------LHNS 535
Query: 7269 LCKQQTSLQAGVLDYETFAKSLEALEAWI------VEAEEILQGQDPSHSSDLSTIQERM 7322
L ++++ LQ+ + ++ F + E L+ + V+AE+ LQ P + LS +Q
Sbjct: 536 LLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQ 595
Query: 7323 EELKGQMLKFSSMAPDLDRLNELGYRLPL---NDKEIKRMQNLNRHWSLISSQTTERFSK 7379
EE LD ++ PL N +M L+ + + + +
Sbjct: 596 EE-------------GLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDR 642
Query: 7380 LQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAH-ELFQAEMFSRQQ 7438
+ + +H TF + +++V T QKL E Q A E AE ++
Sbjct: 643 CRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEKEA 702
Query: 7439 ILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYR 7498
L + G ++E+ + +L L+ W+ +R ++ + S IR W R
Sbjct: 703 QLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR-ALRLLEES---LLSLIRNWHLQR 758
Query: 7499 EMAEKLRKWLVEVSYLPMSGL---GSVPIPLQQAR-TLFDEVQFKEKVF---LRQQGSYI 7551
+ +K +V + +P SG PIP + R L E + + F LR G +
Sbjct: 759 MEVDSGKK-MVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQW- 816
Query: 7552 LTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKC--EK 7609
L VE K + + A++ AE KS LE + + L ++ + +
Sbjct: 817 LQVENSKLVRI-------IAMRTSTAEDLRTRKSKLQELEARVPEGQHLFENLLRLGPAR 869
Query: 7610 GIADSLEKLR----TFKKKLSQS 7628
G +D LE LR +K KL S
Sbjct: 870 GTSDELEDLRYQWMLYKSKLKDS 892
Score = 60.5 bits (145), Expect = 7e-08
Identities = 152/842 (18%), Positives = 315/842 (37%), Gaps = 104/842 (12%)
Query: 2822 EELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDSS 2881
+++K Q+ + +T ++E + YL A EF W L ++
Sbjct: 88 KDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK 147
Query: 2882 ATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWE 2941
Q +LS + L+ + + A L R+ A + + + ++A++
Sbjct: 148 EKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVD--EDAQKRMKAEY---- 201
Query: 2942 DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLTLLEGKNTDEE 3001
D+V +L+ Q+A +E+ V ++F LK +++ G+N
Sbjct: 202 DAVKAKAQKRVDLLEQVAREHEEYQAGV-------DEFQLWLKAVVEKVNGCLGRNCKLP 254
Query: 3002 IVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQA 3061
I + Q+I + E E L+ Q + R + L + K++G ++E + L+
Sbjct: 255 ITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLG--AEKITGELEEMRKV-LEK 311
Query: 3062 SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTS-LQKIQEFLSE 3120
+ +E+ +R R R W K A+ + + ++ LQ + +E
Sbjct: 312 LRALWEEEE---ERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTE 368
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
E H ++ L S ++ + ++ + K ++ ++LK+
Sbjct: 369 DELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHNLKPLSDSVIATIQEYQSLKV 428
Query: 3181 QMKDFEVSA---------EPIQD---WLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLE 3228
+ +A P+QD W + ++++ +++ L DLP+ ++++ L
Sbjct: 429 KSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALM 487
Query: 3229 EIHCYEPQLNRLKEKAQQLWE--GQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIV 3286
E + L L+ K L GQ + + +V+ L N ++ S+L ++
Sbjct: 488 ESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLL 547
Query: 3287 AEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKM 3346
A+H F + LQ + D + + D ++ +L+ L QE+ + +
Sbjct: 548 AQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGL----QEEGLDLGA 603
Query: 3347 IVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVR 3406
+ ++Q +P + Q + + SL RC+ ++ + ++ +
Sbjct: 604 QMEAARPLVQE-NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQ----EHCTFSHQLL 658
Query: 3407 QFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEH 3466
+ W+ L E+ R A D + + + L E + L +E +G + E
Sbjct: 659 ELRQWIVVTTQKL-EAHRGEAGPGDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEK 717
Query: 3467 Y------VTQLELQDLQERYRAIQ--ERAKEAVTKSEKLVRL------------------ 3500
V Q EL++L E +RA++ E + ++ ++ L R+
Sbjct: 718 SSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNWHLQRMEVDSGKKMVFTNNIPKSG 777
Query: 3501 -------------------------HQEYQRDLKAFEVWLGQEQEKLDQYSVLE-GDAHT 3534
H+++ + L+ F WL E KL + + A
Sbjct: 778 FLINPMDPIPRHRRRANLLQEEEGSHEDFSQLLRNFGQWLQVENSKLVRIIAMRTSTAED 837
Query: 3535 HETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLS 3594
T LQEL+ EGQ H E+++ G + LE LR W Y+ +L
Sbjct: 838 LRTRKSKLQELEARVPEGQ-------HLFENLLRLGPARGTSDELEDLRYQWMLYKSKLK 890
Query: 3595 ET 3596
++
Sbjct: 891 DS 892
Score = 60.5 bits (145), Expect = 7e-08
Identities = 159/775 (20%), Positives = 294/775 (37%), Gaps = 146/775 (18%)
Query: 6924 QLGAMNKSWQ-----ILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQH 6978
QLG K WQ +L V + LL+ LLE + N
Sbjct: 143 QLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFN-------------------- 182
Query: 6979 RIGDQASVQNALKDCQDLEDLIKAK-EKEVEKIEQNGLALIQNKKEDVSSIVMSTLRELG 7037
RIGD + ++A K + D +KAK +K V+ +EQ RE
Sbjct: 183 RIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQ-------------------VAREHE 223
Query: 7038 QTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQV 7097
+ A +D + ++ LK+V++ K+N L +
Sbjct: 224 EYQAGVD----EFQLWLKAVVE----------KVNGCLGR------------NCKLPITQ 257
Query: 7098 QVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNM---RWNNLLE 7154
++ LQ++ D + E SL+ + +++ P E +T L+E+ + L E
Sbjct: 258 RLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE 317
Query: 7155 EIAEQLQSSKALLQLW-QRYKDYSKQCASTVQQQEDRTNELLKAATNKDIADDEVATWIQ 7213
E E+L+ W Q+ K + + + E L+ A D+ VA W +
Sbjct: 318 EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRR 377
Query: 7214 DCN------------DLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQH 7261
D L+ +K+ + F H L + + S + IQ Q SL
Sbjct: 378 YSATRAALASEEPRVDRLQA--QLKELIVFPHNL-----KPLSDSVIATIQEYQ-SLKVK 429
Query: 7262 LCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQER 7321
L A A V ++ F + L+ L+ W A+ +L+ + DL ++
Sbjct: 430 SARLRNA---------AAVELWQHFQRPLQDLQLWKALAQRLLEVT--ASLPDLPSLHTF 478
Query: 7322 MEELKGQMLKFSSMAPDLDRLN-ELGYRLPLNDKE-----IKRMQNLNRHWSLISSQTTE 7375
+ +++ +++ S + L L + + + +E ++++ R L+ + +
Sbjct: 479 LPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQ 538
Query: 7376 RFSKLQSFLLQHQTF------LEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELF 7429
R SKLQS L QH+ F L++ ++ VQ E+ L ++ G L Q E
Sbjct: 539 RKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQE-- 596
Query: 7430 QAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDS 7489
+ + Q + V + K+ LS+ +Q + R +
Sbjct: 597 -----------EGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQ 645
Query: 7490 QIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSV-PIPLQQARTLFDEV--QFKEKVFLRQ 7546
+++ + +LR+W+V + + G P + F+ + +F EK
Sbjct: 646 SVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEFPEK----- 700
Query: 7547 QGSYILTVEAGKQLLLSADSGAEAA-LQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWE 7605
+ + VEA L++ S AA +Q EL E+ E W+ ++RL E+ L L+++W
Sbjct: 701 -EAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWR--ALRLLEE--SLLSLIRNWH 755
Query: 7606 KCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQL 7660
+ + + T S L + + + + R L+ GS +D +QL
Sbjct: 756 LQRMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRRANLLQEEEGS-HEDFSQL 809
Score = 58.5 bits (140), Expect = 3e-07
Identities = 142/799 (17%), Positives = 309/799 (38%), Gaps = 75/799 (9%)
Query: 2418 FSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEG 2477
F S+++ Q W + + + + G LEA+L + + I +G+ ++D V +
Sbjct: 9 FDRSVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMA 68
Query: 2478 QTLYAHL---SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL 2534
+ L A K + + + I EE ++ C + + SE D+ +
Sbjct: 69 EALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYR- 127
Query: 2535 NLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEE 2594
W +M E E + + EK+ ++ ++ L + LD+L + L
Sbjct: 128 --WFQKM--MVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNR 183
Query: 2595 GHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRL 2654
+ ++ + + ++++ + +EHE + + W+KA+ +++
Sbjct: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKV 243
Query: 2655 ACAESTLG--SKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQT 2712
LG K + +RLS +QDI GE L + +R+++ G I
Sbjct: 244 ---NGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITG 300
Query: 2713 QLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPG 2772
+LE +++V LE + + W + ER L + + +Q+I+ Q +
Sbjct: 301 ELEEMRKV--------------LEKLRALWEEEEERLRGLLRSRGAWEQQIK---QLEAE 343
Query: 2773 LKEKFVLLDHL-QSILSEA-----EDHTRALHRLIAKSRELYEKTEDESFKDTAQ-EELK 2825
L E ++L L Q L A ED A R + +R E + AQ +EL
Sbjct: 344 LSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKELI 403
Query: 2826 TQFNDIMTVAKEKMRKVEEI----VKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSG--- 2878
+++ ++ + ++E VK + A E ++L W ++
Sbjct: 404 VFPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLL 463
Query: 2879 DSSATQKKLSKIKELIDSREIGASRLSRVESLAP--EVKQNTTAS--GCELMHTEMQALR 2934
+ +A+ L + + E SR++ L ++K++ G E ++ +
Sbjct: 464 EVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVA 523
Query: 2935 ADWKQWE---DSVFQTQSCLENLVSQMALSEQEFSGQVAQLEQALEQFSALLKTWAQQLT 2991
+ + +S+ Q +S L++L++Q ++F L++ L ++
Sbjct: 524 GSMRDRDLLHNSLLQRKSKLQSLLAQ----HKDFGAAFEPLQRKLLDLQVRVQAEKGLQR 579
Query: 2992 LLEGKNTD-EEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGL 3050
L GK + +G ++ ++ A P ++ + +++ + S D + L
Sbjct: 580 DLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDL 639
Query: 3051 IKEYNCLCLQA-SKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAK--CFDIPQNISEV 3107
+ C Q+ + C Q+L+ R QW+V +TT K +
Sbjct: 640 VDR----CRQSVQEHCTFSHQLLELR---------QWIV---VTTQKLEAHRGEAGPGDA 683
Query: 3108 STSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSN 3167
+ + + ++E + +L+++ ++G L+ + E A +Q ++ E W+
Sbjct: 684 ESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAESWRALRLL 743
Query: 3168 LHQKESALENLKIQMKDFE 3186
S + N +Q + +
Sbjct: 744 EESLLSLIRNWHLQRMEVD 762
Score = 58.2 bits (139), Expect = 4e-07
Identities = 143/777 (18%), Positives = 288/777 (37%), Gaps = 92/777 (11%)
Query: 2855 AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEV 2914
+V + W+ + +++L + G +A + +L + +++ G R+ V +A +
Sbjct: 12 SVEDAQAWMKAVQDQLQVNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLRMAEAL 71
Query: 2915 KQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV------SQMALSEQEFSGQ 2968
+ ++ ++A QWE++V C + S+ L+ EF
Sbjct: 72 LACCPGDQKPGILARLKDIKA---QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRW 128
Query: 2969 VAQLEQALE-----QFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRT 3023
++ LE Q K W + N D + V +LD L
Sbjct: 129 FQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAV--------LLDRL------L 174
Query: 3024 EDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQR--FRKAFR 3081
E+ S N + D S + EY+ + +A K EQ+ ++ ++
Sbjct: 175 EEAASLFNRI----GDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
Query: 3082 DFQQWLV------------NAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLN 3129
+FQ WL N K+ + Q+I++ ++ E L E G +
Sbjct: 231 EFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNT 290
Query: 3130 MMLSKGELLSTLLTKEKAKGIQAKVTAA-KEDWKNFHSNLHQK---ESALENLKIQMKDF 3185
L ++ L E+ + + K+ A +E+ + L + E ++ L+ ++ +F
Sbjct: 291 SPLGAEKITGEL---EEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEF 347
Query: 3186 EVSAEPI-QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKA 3244
+ + + Q+ L K E +L A R ++ L EP+++RL+ +
Sbjct: 348 RMVLQRLAQEGLQPAAKAGTED-----ELVAHWRRYSATRAALAS---EEPRVDRLQAQL 399
Query: 3245 QQLWEGQAASKSFRHRVSQLSSQYLALSN---LTKEKVSRLDRIVAEH--NQFSLGIKEL 3299
++L F H + LS +A K K +RL A F +++L
Sbjct: 400 KELIV-------FPHNLKPLSDSVIATIQEYQSLKVKSARLRNAAAVELWQHFQRPLQDL 452
Query: 3300 QDWMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTS 3359
Q W A +L+ D L + ++EA L + + M+ + + ++
Sbjct: 453 QLWKALAQRLLEVTAS-LPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
Query: 3360 PEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANL 3419
E + +Q+ L ++ ++ KS+L+ L++ + + ++ +
Sbjct: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
Query: 3420 NESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQER 3479
+ +L K L + + L EE L + +E H Q ++ L
Sbjct: 572 QAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH---QHKMDQLSSD 628
Query: 3480 YRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQEKLDQY--SVLEGDAHTHET 3537
++A+Q ++ V + + V+ H + L W+ +KL+ + GDA + E
Sbjct: 629 FQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEA 688
Query: 3538 TLRDL------QELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQA 3588
L +E Q+ E Q L E P G ++ L L + W+A
Sbjct: 689 EFERLVAEFPEKEAQLSLVEAQGWL-----VMEKSSPEGAAVVQEE-LRELAESWRA 739
Score = 52.0 bits (123), Expect = 3e-05
Identities = 143/725 (19%), Positives = 270/725 (37%), Gaps = 93/725 (12%)
Query: 5443 QAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLL 5502
+A+ R+ L Q A EEY ++ W++ +G + N + ++ Q +
Sbjct: 207 KAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIA 266
Query: 5503 EESKEIDSELEAMTEKLQYL---TSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDA 5559
++ + LE + E+ + TS EK++ ++ E+ + E+LR + + + L+
Sbjct: 267 KDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGL 326
Query: 5560 AKDMKKFEAELKKLQAALEQAQATL-------TSPEVGRLSLKEQLSHRQHLLSEMESLK 5612
+ +E ++K+L+A L + + L P + E ++H + + +L
Sbjct: 327 LRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALA 386
Query: 5613 PKVQAVQLCQSALR----IPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQ 5668
+ V Q+ L+ P ++ PL + + +E L+ ++ + AA V+
Sbjct: 387 SEEPRVDRLQAQLKELIVFPHNL---KPLSDSVIATIQEYQSLK---VKSARLRNAAAVE 440
Query: 5669 YEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLN 5728
Q+ Q QL + + + + + ++ L + + E + +E + L
Sbjct: 441 LWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQ 500
Query: 5729 SKCKML--TMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAG------ 5780
K +L + AT LL +V G + L LL S S++
Sbjct: 501 LKKDLLIGIFGQERATALL--EQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFE 558
Query: 5781 -RCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5839
LL E+G ++ A ++ Q L E L
Sbjct: 559 PLQRKLLDLQVRVQAEKGLQRDLPGKQA----------------QLSRLQGLQEEGLDL- 601
Query: 5840 AAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQD 5899
A++ + QE P + D Q +L++++ ++++ E + +
Sbjct: 602 GAQMEAARPLVQE--NPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLE 659
Query: 5900 SLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEE--- 5956
Q I + +E E+ PG ESQ AE + L+ E E Q SL E
Sbjct: 660 LRQWIVVTTQKLEAHRGEA-GPG-DAESQEAEFERLVAEF-----PEKEAQLSLVEAQGW 712
Query: 5957 LVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQR 6016
LV E ++ P +Q L LAE +R LLEE L + +
Sbjct: 713 LVME--KSSPEGAAVVQEELRELAESWRALR--------LLEESLLSLIRNWHLQ----- 757
Query: 6017 YRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSE----- 6071
R E D + + L P +P+ + N+L E E S+
Sbjct: 758 -RMEVDSGKKMVFTNNIPKSGFLINPMDPIPRHRRR---ANLLQEEEGSHEDFSQLLRNF 813
Query: 6072 ---LSVHNENL--LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNM---QGTA 6123
L V N L ++ + T ++ KL+ L+ + E Q L + L + +GT+
Sbjct: 814 GQWLQVENSKLVRIIAMRTSTAEDLRTRKSKLQELEARVPEGQH-LFENLLRLGPARGTS 872
Query: 6124 QEKEE 6128
E E+
Sbjct: 873 DELED 877
Score = 47.0 bits (110), Expect = 8e-04
Identities = 60/344 (17%), Positives = 131/344 (38%), Gaps = 14/344 (4%)
Query: 7820 DKNMSSLRTWLAHIESELAKPIVYDSCNSEE--IQRKLNEQQELQRDIEKHSTGVASVLN 7877
D+++ + W+ ++ +L V D+ ++ +L E +++ + + V VL
Sbjct: 10 DRSVEDAQAWMKAVQDQLQ---VNDNTQGPRAALEARLWETEKICQLEPEGRVRVDLVLR 66
Query: 7878 LCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDY 7937
+ E LL AC + I +++ +W +IE W W ++L
Sbjct: 67 MAEALL----ACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLAR 122
Query: 7938 SRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLAR 7997
F W + T P + KE+ + Q +H Q L+++ A
Sbjct: 123 DEFYRWFQKMMVTLE-PHIE--LQLGLKEKQWQLSHAQVLLHNVDNQAVLLDRLLEEAAS 179
Query: 7998 E-NRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEM 8056
NR + +D ++ + + L+ + EE++ D +WL +
Sbjct: 180 LFNRIGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAV 239
Query: 8057 DLQLTN-IEHFSECDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIE 8115
++ + + + ++ L+ ++ +E + Q +I + PL A I
Sbjct: 240 VEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKIT 299
Query: 8116 EELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHDLSDRELELE 8159
EL+E+R+ +++ E ++L L + ++LE E
Sbjct: 300 GELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAE 343
Score = 47.0 bits (110), Expect = 8e-04
Identities = 73/378 (19%), Positives = 145/378 (38%), Gaps = 60/378 (15%)
Query: 1639 LQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVK 1698
++ Q+E+ + + +E + HW F W ++ P +++ +
Sbjct: 90 IKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLE-PHIELQLGLKE 148
Query: 1699 VEGELQLIQALQNEVVSQASFYSKLLQLKESLFS-----VASKDDVKMMKLHLEQLDERW 1753
+ +L Q L + V +QA +LL+ SLF+ +D K MK + + +
Sbjct: 149 KQWQLSHAQVLLHNVDNQAVLLDRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK- 207
Query: 1754 RDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRH 1813
KR++ L+ V EH+++ + F +W+
Sbjct: 208 ------AQKRVDLLEQVAREHEEYQAGVDEFQLWL------------------------- 236
Query: 1814 KDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLA 1873
K ++ + G L + L + L LQ A+D F EE+ + +E +
Sbjct: 237 ----------KAVVEKVNGCLGRNCKLPITQRLSTLQDIAKD-FPRGEESLETLEEQSAG 285
Query: 1874 LSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSL 1933
+ L + ++G L ++R+ +E ++ + E E+ L L++ A E L
Sbjct: 286 VIRNTSPLGAE-KITGELEEMRKVLEKLRALWEEE----EERLRGLLRSRGAWEQQIKQL 340
Query: 1934 DGILSKAQYHLKIGSSE--QRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQ 1991
+ LS+ + L+ + E Q + T D+L R SE + L Q
Sbjct: 341 EAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRL----Q 396
Query: 1992 DQKEELLKSIEDIEERTD 2009
Q +EL+ +++ +D
Sbjct: 397 AQLKELIVFPHNLKPLSD 414
Score = 46.6 bits (109), Expect = 0.001
Identities = 94/452 (20%), Positives = 169/452 (37%), Gaps = 49/452 (10%)
Query: 8017 RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK 8076
+W+ +T R++ E+ ARD W +M + +E E + K K
Sbjct: 93 QWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQKM---MVTLEPHIELQLGLKEK 149
Query: 8077 QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDE--LRRYCQEVFGRVER 8134
Q + ++ L HN Q + ++L+E++ L I + +DE +R E +
Sbjct: 150 QWQLSHAQVLL-HNVDNQAVLL-DRLLEEAASLFNRIGDPSVDEDAQKRMKAEYDAVKAK 207
Query: 8135 YHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSLSLAQPL 8194
K++ L EH+ E A + + ++ ++ N L + Q L
Sbjct: 208 AQKRVDLLEQVAREHE--------EYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRL 259
Query: 8195 RSERS-GRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGL 8253
+ + +D P +S+ + + R+ + + E EE +
Sbjct: 260 STLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRK------------ 307
Query: 8254 SDVMIPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENI---IRS 8310
+ E A + E ++ A E QI+QL L + R +Q+ +
Sbjct: 308 ----VLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAA 363
Query: 8311 KTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFV-NLHSTETQTAGV 8369
K T EL ++ Y +S V RL+ +LKE L F NL
Sbjct: 364 KAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE----LIVFPHNLKPLSDSVIAT 419
Query: 8370 IDRWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRL----ELST 8425
I ++ L+ + S LR ++ WQ F L + W + LE L L T
Sbjct: 420 IQEYQSLKVK--SARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT 477
Query: 8426 DIQTIE---LQIKKLKELQKAVDHRKAIILSI 8454
+ IE ++ +LKEL + +K +++ I
Sbjct: 478 FLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
Score = 45.8 bits (107), Expect = 0.002
Identities = 144/812 (17%), Positives = 323/812 (39%), Gaps = 96/812 (11%)
Query: 7284 ETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLN 7343
+ F +S+E +AW+ ++ LQ D + + ++ R+ E + K + P+
Sbjct: 7 DDFDRSVEDAQAWMKAVQDQLQVNDNTQGPR-AALEARLWETE----KICQLEPEGRVRV 61
Query: 7344 ELGYRL--------PLNDKE--IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEK 7393
+L R+ P + K + R++++ W + T S+++ L
Sbjct: 62 DLVLRMAEALLACCPGDQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLH------- 114
Query: 7394 CETWMEFLVQTE------QKLAVEISGNYQHLLE-QQRAHELFQAEMFSRQQILHSIIID 7446
W E+L+ + QK+ V + + + L +++ +L A++ ++++D
Sbjct: 115 ---WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLLHNVDNQAVLLD 171
Query: 7447 GQRLLEQG----------QVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQR 7496
RLLE+ VD+ + +K ++ V +AQ+R +++ R+ +
Sbjct: 172 --RLLEEAASLFNRIGDPSVDEDAQKRMKA-----EYDAVKAKAQKRVDLLEQVAREHEE 224
Query: 7497 YREMAEKLRKWLVEVSYLPMSGLG-SVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7555
Y+ ++ + WL V LG + +P+ Q + ++ K F R + S E
Sbjct: 225 YQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDI---AKDFPRGEESLETLEE 281
Query: 7556 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKD---WEKCEKGIA 7612
++ + + EL E+++ + EE++++L LL+ WE+ K +
Sbjct: 282 QSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAWEQQIKQLE 341
Query: 7613 DSLEKLRTFKKKLSQ------SLPDHHEELHAEQMRCKELENAVGSWTDDLTQL-SLLKD 7665
L + R ++L+Q + +EL A R A+ S + +L + LK+
Sbjct: 342 AELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVDRLQAQLKE 401
Query: 7666 TLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW- 7724
+ + ++ L++ V ++++ L ++ R + + W F ++L W
Sbjct: 402 LI---VFPHNLKPLSDSVIATIQEYQSL--KVKSARLRNAAAVELWQHFQRPLQDLQLWK 456
Query: 7725 -LTQMESKVSQNGDIL--IEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKA 7781
L Q +V+ + L + + +++ E + +E LQ + L + +A
Sbjct: 457 ALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRL-KELLTMLQLKKDLLIGIFGQERA 515
Query: 7782 SE-IEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWL--AHIESELA 7838
+ +E G + DR L + + R KL+ L + L+ L + +
Sbjct: 516 TALLEQVAGSMRDR-DLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRVQAE 574
Query: 7839 KPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSI 7898
K + D + +L QE D+ ++ H D ++D + ++
Sbjct: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNHQHKMDQLSSDFQ--AL 632
Query: 7899 QQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWL-KSSERTAAFPSSS 7957
Q++ +L R C S++ F W+ ++++ A +
Sbjct: 633 QRSLEDLVDR----CRQSVQEHC----------TFSHQLLELRQWIVVTTQKLEAHRGEA 678
Query: 7958 GVIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQR 8017
G A+ + +FE + E QL L+ Q + ++ + A +++ + E +
Sbjct: 679 GP--GDAESQEAEFERLVAEFPEKEAQLSLVEAQGWLVMEKSSPEGAAVVQEELRELAES 736
Query: 8018 WDNLQKRVTSILRRLKHFIGQREEFETARDSI 8049
W L+ S+L ++++ QR E ++ + +
Sbjct: 737 WRALRLLEESLLSLIRNWHLQRMEVDSGKKMV 768
Score = 45.4 bits (106), Expect = 0.002
Identities = 82/429 (19%), Positives = 166/429 (38%), Gaps = 64/429 (14%)
Query: 1410 ASEIPLGPQNKQLLQQQAKSIKEQV-----KKLEDTLEEDIKTMEMVKTKWDHFGSNFET 1464
A + P G ++ + L++Q+ + +K+ LEE K +E ++ W+
Sbjct: 266 AKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLEKLRALWE-------- 317
Query: 1465 LSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIV--GLEEEAQSFAQFVT 1522
E+E+ L L S A + QI Q++ + E L + GL+ A++ +
Sbjct: 318 ------EEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDEL 371
Query: 1523 TGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSV-SEFEDK 1581
R A T+ EE R + L + F NL+ + SV + ++
Sbjct: 372 VAHWRRYSA--TRAALASEEPRVDR------LQAQLKELIVFPHNLKPLSDSVIATIQEY 423
Query: 1582 LAVPIKIC----SSATETYKVLQEHMDLCQALESLSSAITAFSASA-------------R 1624
++ +K ++A E ++ Q + Q ++L+ + +AS
Sbjct: 424 QSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHTFLPQIE 483
Query: 1625 KVVNRDSCVQEAAALQQQYEDILRR--AKERQTALENLLAHWQRLEKELSSFLTWLERGE 1682
+ S ++E + Q +D+L +ER TAL +A R L + L +
Sbjct: 484 AALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKL 543
Query: 1683 AKASSPEMDISADRVKVEGEL-------QLIQALQNEVVSQASFYSKLLQLKESLFSVAS 1735
+ D A ++ +L Q + LQ ++ + + S+L L+E + +
Sbjct: 544 QSLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLSRLQGLQEEGLDLGA 603
Query: 1736 KDDVKMMKLH--------LEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVW 1787
+ + + ++QL ++ L + + ++ + V EH F LL W
Sbjct: 604 QMEAARPLVQENPNHQHKMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQW 663
Query: 1788 IKLFLSELQ 1796
I + +L+
Sbjct: 664 IVVTTQKLE 672
Score = 43.9 bits (102), Expect = 0.007
Identities = 127/632 (20%), Positives = 245/632 (38%), Gaps = 101/632 (15%)
Query: 5032 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5091
W +Y AR+E L L+ E + +LS + L+ V++ + L
Sbjct: 115 WSEYLLARDEFYRWFQKMMVTLEPHIELQLGLK-EKQWQLSHAQVLLHNVDNQAVLLDRL 173
Query: 5092 -EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVK 5150
EE AS + G+ + + M + ++A AQ + +LE E + V
Sbjct: 174 LEEAASLFNRIGDPSVDEDAQKRMKA---EYDAVKAKAQKRVDLLEQVAREHEEYQAGVD 230
Query: 5151 KATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQD 5210
+ + + +K+ G K + L + + + +L L +Q+ ++++
Sbjct: 231 EFQLWLKAVVEKVNGCLGRNC-KLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRN 289
Query: 5211 GAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQE 5270
+ P ++IT + + EK++ + ++ E + + S W Q+
Sbjct: 290 TS-------PLGAEKITGELEEMRKVLEKLRALWE------EEEERLRGLLRSRGAWEQQ 336
Query: 5271 TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLA 5330
K+ ++A+L E +++L ++ ++ A+ E L + S A
Sbjct: 337 IKQ--------LEAELSEFRMVLQRLA--QEGLQPAAKAGTEDELVAHW---RRYSATRA 383
Query: 5331 EVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVV---QA 5387
+A + D++Q ++KE L LK +D+V+ Q
Sbjct: 384 ALASEEPRVDRLQAQLKE---------------------LIVFPHNLKPLSDSVIATIQE 422
Query: 5388 KTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENR 5447
KV L N+ +EL Q+ L Q+ QL K LA+++ ++T ++ +
Sbjct: 423 YQSLKVKSARLR--NAAAVELWQHFQRPL-QDLQLWKALAQRLLEVTA----SLPDLPSL 475
Query: 5448 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQY--------ILHQ 5499
+ L Q + L E + + EL L ++ K L G A+ L EQ +LH
Sbjct: 476 HTFLPQIEAALMESSRLKEL-LTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHN 534
Query: 5500 TLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMI---KIRLQNL 5556
+LL+ ++ S L Q + G E L++ + ++R+Q
Sbjct: 535 SLLQRKSKLQSLLA--------------------QHKDFGAAFEPLQRKLLDLQVRVQAE 574
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQ 5616
+ +D+ +A+L +LQ E+ E R ++E +H QH +M+ L Q
Sbjct: 575 KGLQRDLPGKQAQLSRLQGLQEEGLDLGAQMEAARPLVQENPNH-QH---KMDQLSSDFQ 630
Query: 5617 AVQLCQSAL--RIPEDVVASLPLCHAALRLQE 5646
A+Q L R + V H L L++
Sbjct: 631 ALQRSLEDLVDRCRQSVQEHCTFSHQLLELRQ 662
Score = 40.4 bits (93), Expect = 0.078
Identities = 87/448 (19%), Positives = 187/448 (41%), Gaps = 40/448 (8%)
Query: 5275 LGNPTIEIDAQLE---ELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPSELSLQLAE 5331
+G+P+++ DAQ E + +A +E++A E +E G+ E L L
Sbjct: 184 IGDPSVDEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGV-----DEFQLWLKA 238
Query: 5332 VALDLKIRDQIQDKIK-EVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTD 5390
V K+ + K + Q +T Q++++ + + L T L+ ++ V+ +
Sbjct: 239 VVE--KVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEESLET----LEEQSAGVI--RNT 290
Query: 5391 QKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSK 5450
+ E++ G ++ ++ ++ E+ + + L + G +Q I+Q E LS+
Sbjct: 291 SPLGAEKITGELEEMRKVLEKLRALWEEEEERLRGLLRSRGAW----EQQIKQLEAELSE 346
Query: 5451 LNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEESKEIDS 5510
L + E L+ K + +++AH W S R + ++ +
Sbjct: 347 FRMVLQRLAQ--EGLQPAAKAGTEDELVAH----WRRYSATRAALASEEPRVDRLQAQLK 400
Query: 5511 ELEAMTEKLQYLT-SVYCTEKMSQQVAELGRETEELRQMIKIRL-QNLQDAAKDMKKFEA 5568
EL L+ L+ SV T Q+ L ++ LR + L Q+ Q +D++ ++A
Sbjct: 401 ELIVFPHNLKPLSDSVIAT---IQEYQSLKVKSARLRNAAAVELWQHFQRPLQDLQLWKA 457
Query: 5569 ELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIP 5628
++L + T + P++ SL L + L E LK + +QL + L
Sbjct: 458 LAQRL------LEVTASLPDLP--SLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGI 509
Query: 5629 EDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHR 5688
+ L + L ++ +Q+ + +Q+ + Q++ + + LQ+ +
Sbjct: 510 FGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQV 569
Query: 5689 EIEDKPVATSNIQELQAQISRHEELAQK 5716
++ + ++ QAQ+SR + L ++
Sbjct: 570 RVQAEKGLQRDLPGKQAQLSRLQGLQEE 597
Score = 38.5 bits (88), Expect = 0.30
Identities = 94/549 (17%), Positives = 221/549 (40%), Gaps = 65/549 (11%)
Query: 4805 VTECESRM----VQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ 4860
+T C SR+ + ++ W +++ L + L L L++ Q ++ Q+
Sbjct: 101 MTHCHSRIEWVWLHWSEYLLARDEFYRWFQKMMVTLEPHIELQLGLKEKQWQLSHAQVLL 160
Query: 4861 EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEI 4920
V + +++ L + F + + S D + +E D A++ + ++
Sbjct: 161 HNVDNQAVLLDRLLEEAASLFNRIGDP-SVDEDAQKRMKAEYD-----AVKAKAQKRVDL 214
Query: 4921 YSQCQRYYQVFQAAND----WLEDAQELLQ--LAGN-GLDVESAEENLKSHMEFFSTEDQ 4973
Q R ++ +QA D WL+ E + L N L + L+ + F ++
Sbjct: 215 LEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGRNCKLPITQRLSTLQDIAKDFPRGEE 274
Query: 4974 FHSNLEELHS-LVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQW 5032
LEE + ++ PL +LE+ LE + + + + ++ L R W
Sbjct: 275 SLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVLE-KLRALWEEEEERLRGLLRSRGAW 333
Query: 5033 HDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSE---HKALVSVVNSFHEKIV 5089
K E + ++L++ L + + +E ++ + A + + S ++
Sbjct: 334 EQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTEDELVAHWRRYSATRAALASEEPRVD 393
Query: 5090 ALEEKASQLE------KTGNDASKATLSRSMTTVWQRWTRLRAVA-----QDQEKILEDA 5138
L+ + +L K +D+ AT+ + ++ + RLR A Q ++ L+D
Sbjct: 394 RLQAQLKELIVFPHNLKPLSDSVIATI-QEYQSLKVKSARLRNAAAVELWQHFQRPLQD- 451
Query: 5139 VDEWTGFNNKVKKATEMIDQLQD------KLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5192
+ W ++ + T + L ++ + E + ELLT+L+ ++ +
Sbjct: 452 LQLWKALAQRLLEVTASLPDLPSLHTFLPQIEAALMESSRLKELLTMLQLKKDLLIGIFG 511
Query: 5193 QQSALGMLRQQTLSM-----LQDGAAPTPGEEPPLMQE-------ITAMQDRCLNMQEKV 5240
Q+ A +L Q SM L + + L+ + +Q + L++Q +V
Sbjct: 512 QERATALLEQVAGSMRDRDLLHNSLLQRKSKLQSLLAQHKDFGAAFEPLQRKLLDLQVRV 571
Query: 5241 KTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHR 5300
+ K ++++L ++ +++ ++ +++ AQ+E + L+ E NH+
Sbjct: 572 QAE-KGLQRDLPGKQAQLSRLQGLQ-----------EEGLDLGAQMEAARPLVQENPNHQ 619
Query: 5301 QNIEKMAEE 5309
+++++ +
Sbjct: 620 HKMDQLSSD 628
Score = 33.9 bits (76), Expect = 7.3
Identities = 123/705 (17%), Positives = 259/705 (36%), Gaps = 79/705 (11%)
Query: 585 EEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLN 644
++ ++ + + AQW + S +E V +W Y W + + M+
Sbjct: 78 DQKPGILARLKDIKAQWEETVTYMTHCHSRIEWVWLHWSEYLLARDEFYRWFQ--KMMVT 135
Query: 645 QSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDE---MVSRDLKQQLLLLN------- 694
+ + W H + L+ D ++ R L++ L N
Sbjct: 136 LEPHIELQLGLKEKQWQLSHAQV------LLHNVDNQAVLLDRLLEEAASLFNRIGDPSV 189
Query: 695 -----GRWRELFMEVKQYAQ--ADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFM 747
R + + VK AQ D ++++ +E+ + + F + +
Sbjct: 190 DEDAQKRMKAEYDAVKAKAQKRVDLLEQVAREHEEYQAGVDEFQLWLKAVVEKVNGCLGR 249
Query: 748 NVKLLI----QDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQL 803
N KL I L+DI + P + + + + + + + + +++ + ++++ L
Sbjct: 250 NCKLPITQRLSTLQDIAKDFPRGEESLETLEEQSAGVIRNTSPLGAEKITGELEEMRKVL 309
Query: 804 TKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQ 863
K++ + + LL E+Q+ L + ++ L +E A
Sbjct: 310 EKLRALWEEEEERLRGLLRSRGAWEQQIKQLEAELSEFRMVLQRLAQEGLQPAAKAGTED 369
Query: 864 ELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVA----FQSMV 919
EL+A T + V + L F + ++D +A +QS+
Sbjct: 370 ELVAHWRRYSATRAALASEEPRVDRLQAQLKELIVFPHN--LKPLSDSVIATIQEYQSLK 427
Query: 920 KKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLD- 978
K+ + L + F+ +L+ +AQ LE +L HT F Q++
Sbjct: 428 VKSARLRNAAAV--ELWQHFQRPLQDLQLWKALAQRLLEVTASLPDLPSLHT-FLPQIEA 484
Query: 979 --------QRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLK 1030
+ +L D L I ++ L E V + L L+
Sbjct: 485 ALMESSRLKELLTMLQLKKDLLIGIFGQERATALLEQVAGSMRDRDLLHNSLLQRKSKLQ 544
Query: 1031 IDVEKNR-FLASVEEC-RTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEKRLQLI 1088
+ +++ F A+ E R LD + ++ ++G ++ + + S RLQ +
Sbjct: 545 SLLAQHKDFGAAFEPLQRKLLDLQVRVQAEKGLQRDLPGKQAQLS----------RLQGL 594
Query: 1089 EELCVKL-----PVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKD-------Y 1136
+E + L R V++ P H + +L + + R L + D+ + +
Sbjct: 595 QEEGLDLGAQMEAARPLVQENPNHQH-KMDQLSSDFQALQRSLEDLVDRCRQSVQEHCTF 653
Query: 1137 TSRFSEFSSWISTNETQLKGIKGEA---IDTANHGEVKRAVEEIRNGVTKRGETLSWLKS 1193
+ + E WI +L+ +GEA + E +R V E ++ LS +++
Sbjct: 654 SHQLLELRQWIVVTTQKLEAHRGEAGPGDAESQEAEFERLVAEF----PEKEAQLSLVEA 709
Query: 1194 RLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNF 1238
+ ++ E SS A +EL +L+ S++AL L + ++ N+
Sbjct: 710 QGWLVMEKSSPEGAAVVQEELRELAESWRALRLLEESLLSLIRNW 754
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 266 bits (680), Expect = 7e-70
Identities = 597/2895 (20%), Positives = 1117/2895 (38%), Gaps = 516/2895 (17%)
Query: 12 RDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLS 71
R I N + L+DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLS
Sbjct: 5 RAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLS 62
Query: 72 GQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLG 131
G LP E+GR R H + N+ AL +L R+ +KLVNI + DIADG P + LG
Sbjct: 63 GDSLPREKGRM--RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDIADGNPKLTLG 113
Query: 132 LMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKAL 191
L+WTIIL+FQI ++ S S D AK+ L
Sbjct: 114 LIWTIILHFQISDI----------QVSGQSEDM---------------------TAKEKL 142
Query: 192 LKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFT 251
L W Q G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF+
Sbjct: 143 LLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFS 202
Query: 252 IAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPS 311
+AE +LG+ RLLDPEDVDV +PDEKSI+TYV+ P + + DG +E+ +
Sbjct: 203 VAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQE 261
Query: 312 FANSVQNF------------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKY 355
+ V +R F+E+++ QF E +L + ++ + Y
Sbjct: 262 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 321
Query: 356 QSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLP 415
QS + ++K H + GKL + L ++ R + ++ L
Sbjct: 322 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQ 380
Query: 416 APLGTIGAWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL------------- 460
G L +A+ L+ ++ + + + A ++R L++ ++
Sbjct: 381 MEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDG 440
Query: 461 ---QNTDAHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLM 508
Q ++R + HE Y R G+ P Q+ V+ S
Sbjct: 441 RHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRP 493
Query: 509 KMEFLELKYRLLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIEN 556
++E L+Y L LL E L S + G + Q ++ + + IE
Sbjct: 494 ELEDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIER 552
Query: 557 SKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVR 612
++ E Q+ T Y G ++ K +N + A+ R+L S + +
Sbjct: 553 ARSDEG-----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATK 605
Query: 613 SML-------EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN-- 656
++ EEV +W DR N A +++ LE EK + + +NA R
Sbjct: 606 ELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDH 665
Query: 657 --LPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMD 714
P A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 666 PARPTVESFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ--- 715
Query: 715 RMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIIT 774
L +K S + ++ L+QD +D ++++ +
Sbjct: 716 ------------LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 763
Query: 775 KTAHLITKESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEE 826
K A + + P+ M + +++ + K EC QL+ P +
Sbjct: 764 KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQP 814
Query: 827 LEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSV 886
++ S S + + ++ Q + ++ +T +E Q++
Sbjct: 815 SHWKVLSSSGSEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL 857
Query: 887 QKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAEL 946
VTL + L H D L +A+QS+ + + R +K EE R L
Sbjct: 858 ---VTLWHQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQAL 904
Query: 947 EKVLRIAQEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQ 1001
+ Q L + D PE+ L E+ S C L + +
Sbjct: 905 HSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLE 951
Query: 1002 QGLQEAVR--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRET 1053
QG QE R + + KD LQ EA H L L +D E R EC + +
Sbjct: 952 QGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQ 1005
Query: 1054 KLMPQ-EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTL 1112
K + EG K + RL E + LP P T
Sbjct: 1006 KAQAEVEGLGKGV-----------------ARLSAEAEKVLALPEPSPAAPT-------- 1040
Query: 1113 KELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAI 1162
LR+ ++ T KL + Y + S + +E QLK +
Sbjct: 1041 --LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPA 1098
Query: 1163 DTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDE 1213
K +++++R + T L+ L+ EV + E ++ +
Sbjct: 1099 TLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER 1158
Query: 1214 LAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AE 1267
+A+L ++A++ ++ L G ++Y + L + ++ QEQ A+
Sbjct: 1159 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1218
Query: 1268 KILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL-------------- 1313
E L + Q LL ++ +++ +R +Q I + E L
Sbjct: 1219 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1278
Query: 1314 --------PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQ 1365
+ +E L + L + + I TLR+ E E E Q
Sbjct: 1279 KKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------Q 1332
Query: 1366 TGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNK 1420
ER L + + LE+ ++ ++ QAE KE E+ +
Sbjct: 1333 RAEERER------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 1421 QLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALE 1480
QQQ +SI+E++++L + E +I+ + E I +L A E
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATE 1443
Query: 1481 TSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIR 1537
+ ++ ++ +E E++ +EEA+ + V + +A++ ++++
Sbjct: 1444 RQRGGAEGELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Query: 1538 RYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYK 1597
E RE + L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1501 AEAEAAREKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA-- 1554
Query: 1598 VLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA- 1656
L S +F+ ++ S +E A+ Q E+ RRA+++ A
Sbjct: 1555 -------------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAE 1599
Query: 1657 -----LENLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGE 1702
E L WQ RL+ E + L + EA+ E + A R G+
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGK 1656
Query: 1703 LQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINK 1762
+ Q E+ Q + L + +A++ ++ ++ EQ +++ + L + + +
Sbjct: 1657 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1716
Query: 1763 RINFLQSVVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKD 1815
+ + Q+ + L +++ L+ E ++TSE S + R ++
Sbjct: 1717 LQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1776
Query: 1816 HAAE-------VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQ 1850
A E E K + Q + A KL ++G A ++ L +
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE 1836
Query: 1851 GKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESD 1910
+AE+ E ++ E L E H + I +L Q +A++S + +
Sbjct: 1837 KEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKG 1889
Query: 1911 LIEKDLNDALQNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRAT 1958
L+E L Q + + + S + KA+ L++G S EQ A
Sbjct: 1890 LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR 1949
Query: 1959 ADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPT 2017
QL E ER + ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E
Sbjct: 1950 QRQLAAEEERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERA 2006
Query: 2018 RQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDT 2077
Q ++L++ + K Q +K AFA V ++ L+ T
Sbjct: 2007 EQESARQLQLAQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQE 2050
Query: 2078 KRLIHENQGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHE 2136
+ ++ + +G+ E + + A + ++ V + E+ A ++ +
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110
Query: 2137 TAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENM 2196
A K+ + + ++ + K+ ++ K E T L ++E+ +
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQEL 2166
Query: 2197 DRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESE 2250
LR+ L D + DE + A S ++ L + EEL K + E
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2226
Query: 2251 VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFT 2310
+N+AL L + K N + L + E + A L + A + ++A+ +D
Sbjct: 2227 AENRALILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLA 2280
Query: 2311 AQSTQVEKFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISS 2365
Q EK + + V+E+ A+ E + A ++ + +Q++ + ++
Sbjct: 2281 QQRALAEKMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
Query: 2366 TQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEF 2425
+ +LE A ++ E S+ QA +E ++ F + +E
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEI 2391
Query: 2426 QEWFLGAKAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHL 2484
E + A +E ++ + HD + + +++++ + + + + QE + L L
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QL 2449
Query: 2485 SKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEE 2543
+ + ++Q++ Q L++ QALQ SE S + R + ++E+
Sbjct: 2450 KSEEMQTVQQE-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2496
Query: 2544 RFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGR 2603
F E + +++Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2497 LFQDE-VAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE-- 2549
Query: 2604 LCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGS 2663
L ++ +++ + ++ +E++ L E LQ + +A LA +E S
Sbjct: 2550 ----------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTAS 2596
Query: 2664 KDTLEKRLSQIQDIL 2678
+ K L +D L
Sbjct: 2597 QVAATKTLPNGRDAL 2611
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 227 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 286
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 287 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 329
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 330 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 378
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 379 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 436 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 492
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 493 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 549
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 550 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 601
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 602 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 659
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 660 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 717
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 718 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 777
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 778 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 832
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 833 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 892
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 893 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 952
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 953 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1007
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1008 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1065
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1126 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1246 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1303
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1304 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1359
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1360 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1397
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1442
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1443 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1492
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1493 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1547
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1608 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1648
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1702
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1759
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1812
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1867
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1868 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2028
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2029 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2086 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2143
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2144 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2203
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2264 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2375
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2376 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2421
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2422 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2462
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2463 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1114 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1160
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1161 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1212
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1213 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1387
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1503
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1683
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1684 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1735
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1736 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1793
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1853
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1974 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2022
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2083 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2117
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2118 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2226
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2227 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2286 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2341
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2342 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2384
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2434
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2489 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2544
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2601
Query: 6335 ALLP 6338
LP
Sbjct: 2602 KTLP 2605
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 525 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 579
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 580 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 635
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 636 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 674
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 675 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 713
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 714 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 753
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 754 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 810
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 811 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 863
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 864 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 923
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 924 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 982
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 983 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1041
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1042 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1089
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1090 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1142
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1143 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1202
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1203 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1259
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1260 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1319
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1320 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1380 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1434
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1435 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1495 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1599
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1659
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1718 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1759
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1760 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1812
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 1873 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 1923
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 1981
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 1982 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2032
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2092
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2093 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2152
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2153 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2204
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2205 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2324 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2376
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2377 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2434
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2435 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2481 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2505
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1122
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1242
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1243 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1302
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1303 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1362 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1418
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1419 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1466
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1467 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1520
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1577
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1814
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1869
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2050 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2209
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2210 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2239
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2240 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2299
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2300 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2466 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2500
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 956 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 1006
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1062
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1118
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1119 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1177
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1178 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1225
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1226 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1280
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1281 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1333
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1334 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1389
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1390 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1449
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1450 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1507
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1563
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1564 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1615
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1674
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1675 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1716 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1767
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1828 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 1940 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 1990
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 1991 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2028
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2029 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2085
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2125
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2126 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2180
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2181 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2229
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2230 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2279
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2280 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2326
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2327 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2385 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2438 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2548
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2549 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2604 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2651
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 370 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 426
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 427 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 479
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 480 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 536
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 537 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 591
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 592 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 649
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 650 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 706
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 707 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 766
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 767 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 826
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 827 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 884
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 885 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 940
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 941 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 996
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 997 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1050
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1165
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1286 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1345
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1346 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1405
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1406 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1465
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1525
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1526 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1585
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1645
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1646 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1695
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 1927
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 1986 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2043
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2104 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2154
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2155 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2209
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2210 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2265 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2315 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2372 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2429
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2485
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2486 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2543
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2544 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2570
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1210
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1270
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1387
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1447
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1448 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1507
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1681 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1729
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1780
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1781 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1820
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1821 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1867
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1868 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1921 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1971
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2025
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2082
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2203 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2260 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2319
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2378
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2379 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2484
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2485 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2539
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2540 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2590
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2591 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2642
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2643 S-AEELQRLAQGHTTVDELA 2661
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1120 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1172
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1173 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1232
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1233 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1292
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1339
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1340 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1394
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1575 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1629 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1682
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1683 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1791
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1792 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 1850
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 1851 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1910
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 1911 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2088 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2147
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2268 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2307
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2308 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2367
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2368 AEMSR 2372
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 957 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1004
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1005 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1062
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1121
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1122 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1163
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1164 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1219
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1220 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1272
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1273 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1332
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1333 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1392
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1393 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1511
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1512 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1566
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1567 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1624
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1685 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1743
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1744 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1795
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1796 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1845
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1846 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1890
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1891 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1923
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2041
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2042 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2084
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2139
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2140 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2192
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2252
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2253 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2304
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2305 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2345
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2346 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2399
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2400 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2441
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2442 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2483
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2484 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2534
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2535 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2569
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2570 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2623
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2624 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2680
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2681 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2711
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1110
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1170
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1171 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1229
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1230 QALLEEIE 1237
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 933 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 990
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 991 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1051 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1170
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1171 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1227
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1228 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1267
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1268 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1326
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1387 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1497
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1498 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1557
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1558 SKRASFAEKTAQLERSL 1574
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 263 bits (673), Expect = 4e-69
Identities = 599/2905 (20%), Positives = 1121/2905 (38%), Gaps = 518/2905 (17%)
Query: 2 ATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGV 61
A S G+ P + A + R+ DE++ VQK+TFTKW+N HL K + + DL+ED++DG
Sbjct: 46 AGSNGSVLDPAERAVI--RIADERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGH 101
Query: 62 KLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDI 121
L++LLEVLSG LP E+GR R H + N+ AL +L R+ +KLVNI + DI
Sbjct: 102 NLISLLEVLSGDSLPREKGRM--RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDI 152
Query: 122 ADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTT 181
ADG P + LGL+WTIIL+FQI ++ S S D
Sbjct: 153 ADGNPKLTLGLIWTIILHFQISDI----------QVSGQSEDM----------------- 185
Query: 182 KIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRS 241
AK+ LL W Q G+ +F SWR G F+++IH +P L+D+ V ++
Sbjct: 186 ----TAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 241
Query: 242 NRENLEDAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQE 301
N ENL+ AF++AE +LG+ RLLDPEDVDV +PDEKSI+TYV+ P + + DG
Sbjct: 242 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 300
Query: 302 DDEILPGFPSFANSVQNF------------KREDRVIFKEMKVWIEQF----ERDLTRAQ 345
+E+ + + V +R F+E+++ QF E +L +
Sbjct: 301 ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKE 360
Query: 346 MVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFD 405
++ + YQS + ++K H + GKL + L ++ R +
Sbjct: 361 ADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLE 419
Query: 406 WHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL--- 460
++ L G L +A+ L+ ++ + + + A ++R L++ ++
Sbjct: 420 CLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLL 479
Query: 461 -------------QNTDAHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHF 498
Q ++R + HE Y R G+ P Q+
Sbjct: 480 FNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ------- 532
Query: 499 VSSTSELHLMKMEFLELKYRLLSLLVLAESK------------LKSWIIKYGRRESVEQL 546
V+ S ++E L+Y L LL E L S + G + Q
Sbjct: 533 VTLQSVQRRPELEDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQS 591
Query: 547 LQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL-- 604
++ + + IE ++ E Q+ T Y G ++ K +N + A+ R+L
Sbjct: 592 IEEFRAKIERARSDEG-----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLES 644
Query: 605 --SVEVRSVRSML-------EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSEN 648
S + + ++ EEV +W DR N A +++ LE EK + + +N
Sbjct: 645 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 704
Query: 649 AKKDFFRN----LPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEV 704
A R P A+ +++++ C + LK+ N + + F +V
Sbjct: 705 AGDRLLREDHPARPTVESFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDV 758
Query: 705 KQYAQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVP 764
++ A+ L +K S + ++ L+QD +D ++++
Sbjct: 759 RE-AEGQ---------------LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLN 802
Query: 765 VMDAQYKIITKTAHLITKESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYE 816
+ K A + + P+ M + +++ + K EC
Sbjct: 803 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC------- 855
Query: 817 SQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTL 876
QL+ P + ++ S S + + ++ Q + ++ +
Sbjct: 856 --QLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEA-----------------QEAV 896
Query: 877 TLIEKGSQSVQKFVTLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLM 936
T +E Q++ VTL + L H D L +A+QS+ + + R +
Sbjct: 897 TRLEAQHQAL---VTLWHQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTL 944
Query: 937 KKFEESRAELEKVLRIAQEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDE 991
K EE R L + Q L + D PE+ L E+ S C
Sbjct: 945 KP-EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSH 990
Query: 992 LTDILPEQEQQGLQEAVR--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVE 1043
L + +QG QE R + + KD LQ EA H L L +D E R
Sbjct: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ 1044
Query: 1044 ECRTELDRETKLMPQ-EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVR 1102
EC + + K + EG K + RL E + LP P
Sbjct: 1045 ECAQRIAEQQKAQAEVEGLGKGV-----------------ARLSAEAEKVLALPEPSPAA 1087
Query: 1103 DTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNET 1152
T LR+ ++ T KL + Y + S + +E
Sbjct: 1088 PT----------LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE 1137
Query: 1153 QLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS--------- 1203
QLK + K +++++R + T L+ L+ EV
Sbjct: 1138 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1197
Query: 1204 ENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQ 1263
+ E ++ + +A+L ++A++ ++ L G ++Y + L + ++ Q
Sbjct: 1198 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1257
Query: 1264 EQ------AEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL---- 1313
EQ A+ E L + Q LL ++ +++ +R +Q I + E L
Sbjct: 1258 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1317
Query: 1314 ------------------PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETN 1355
+ +E L + L + + I TLR+ E E
Sbjct: 1318 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1377
Query: 1356 KETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----A 1410
E Q ER L + + LE+ ++ ++ QAE KE
Sbjct: 1378 AEQ------QRAEERER------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 1411 SEIPLGPQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWIT 1470
E+ + QQQ +SI+E++++L + E +I+ + E I
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIR 1482
Query: 1471 EKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK 1530
+L A E + ++ ++ +E E++ +EEA+ + V + +
Sbjct: 1483 VVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQ 1539
Query: 1531 AKL---TQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIK 1587
A++ ++++ E RE + L+ L L Q EE R+++Q+ E ++ V ++
Sbjct: 1540 AEVELASRVKAEAEAAREKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALE 1595
Query: 1588 ICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDIL 1647
+ E L S +F+ ++ S +E A+ Q E+
Sbjct: 1596 TAQRSAEA---------------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAE 1638
Query: 1648 RRAKERQTA------LENLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDI 1692
RRA+++ A E L WQ RL+ E + L + EA+ E +
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 1693 SADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDER 1752
A R G+ + Q E+ Q + L + +A++ ++ ++ EQ +++
Sbjct: 1699 EARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1755
Query: 1753 WRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMD 1805
+ L + + + + + Q+ + L +++ L+ E ++TSE S
Sbjct: 1756 RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1815
Query: 1806 HQVALTRHKDHAAE-------VESKKGELQSLQGHLA------------KLGSLGRA--- 1843
+ R ++ A E E K + Q + A KL ++G A
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875
Query: 1844 ---EDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEA 1900
++ L + +AE+ E ++ E L E H + I +L Q +A
Sbjct: 1876 KTEAEIALKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKA 1928
Query: 1901 TNSMNKNESDLIEKDLNDALQNAKALESAAVSLD-GILSKAQYHLKIG-----------S 1948
++S + + L+E L Q + + + S + KA+ L++G S
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 1949 SEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERT 2008
EQ A QL E ER + ++ +LA ++A + Q++ L+ +E ++ +
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKV 2045
Query: 2009 DK-ERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREI 2067
++ RL+E Q ++L++ + K Q +K AFA V ++
Sbjct: 2046 EEARRLRERAEQESARQLQLAQE--------------AAQKRLQAEEKAHAFA--VQQKE 2089
Query: 2068 NRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQE 2126
L+ T + ++ + +G+ E + + A + ++ V + E
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2149
Query: 2127 DLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWL 2186
+ A ++ + A K+ + + ++ + K+ ++ K E T L
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----L 2205
Query: 2187 DVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAE 2241
++E+ + LR+ L D + DE + A S ++ L + E
Sbjct: 2206 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265
Query: 2242 ELLK-EFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITE 2300
EL K + E +N+AL L + K N + L + E + A L + A + +
Sbjct: 2266 ELSKLKARIEAENRALILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQ 2322
Query: 2301 VAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKE 2355
+A+ +D Q EK + + V+E+ A+ E + A ++ + +Q++
Sbjct: 2323 LAE---EDLAQQRALAEKMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQED 2376
Query: 2356 LQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLE 2415
+ ++ + +LE A ++ E S+ QA +E +
Sbjct: 2377 KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQ 2431
Query: 2416 KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVT 2474
+ F + +E E + A +E ++ + HD + + +++++ + + + +
Sbjct: 2432 R-FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2490
Query: 2475 QEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRK 2533
QE + L L + + ++Q++ Q L++ QALQ SE S + R
Sbjct: 2491 QEAKLL--QLKSEEMQTVQQE-------------QLLQETQALQQSFLSEKDSLLQRERF 2535
Query: 2534 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
+ ++E+ F E + +++Q E++ + ++E L+A+ E ++R Q +E
Sbjct: 2536 IEQEKAKLEQLFQDE-VAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAE 2590
Query: 2594 EGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDR 2653
EG QE L ++ +++ + ++ +E++ L E LQ + +A
Sbjct: 2591 EGVRRKQE------------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---A 2635
Query: 2654 LACAESTLGSKDTLEKRLSQIQDIL 2678
LA +E S+ K L +D L
Sbjct: 2636 LAHSEEVTASQVAATKTLPNGRDAL 2660
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 276 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 335
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 336 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 378
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 379 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 427
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 428 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 484
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 485 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 541
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 542 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 598
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 599 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 650
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 651 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 708
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 709 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 766
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 767 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 826
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 827 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 881
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 882 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 941
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 942 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1001
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 1002 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1056
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1057 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1114
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1175 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1295 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1352
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1353 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1408
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1409 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1446
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1491
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1492 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1541
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1542 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1596
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1657 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1697
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1751
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1752 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1808
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1861
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1916
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1917 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2018
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 2019 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2077
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2078 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2135 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2192
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2193 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2252
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2313 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2369
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2424
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2425 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2470
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2471 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2511
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2512 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2605
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1163 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1209
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1210 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1261
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1262 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1320
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1436
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1552
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1732
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1733 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1784
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1785 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1842
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1843 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1902
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1903 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 2023 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2071
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2132 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2166
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2167 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2224
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2225 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2275
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2276 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2334
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2335 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2390
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2391 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2433
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2483
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2537
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2538 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2593
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2594 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2650
Query: 6335 ALLP 6338
LP
Sbjct: 2651 KTLP 2654
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 574 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 628
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 629 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 684
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 685 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 723
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 724 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 762
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 763 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 802
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 803 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 859
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 860 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 912
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 913 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 972
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 973 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1031
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1090
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1138
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1139 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1191
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1192 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1251
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1252 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1308
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1309 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1368
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1369 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1428
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1429 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1483
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1544 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1598
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1599 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1648
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1708
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1709 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1767 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1808
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1809 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1861
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1862 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 1922 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 1972
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 2030
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 2031 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2081
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2141
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2142 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2201
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2202 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2253
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2254 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2373 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2425
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2426 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2483
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2484 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2529
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2530 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2554
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1171
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1172 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1231
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1232 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1291
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1292 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1351
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1352 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1411 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1467
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1468 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1515
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1516 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1569
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1626
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1863
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1864 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1918
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2099 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2258
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2259 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2288
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2289 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2348
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2349 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2455 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2515 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2549
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2609
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2610 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 1005 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 1055
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1111
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1167
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1168 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1226
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1227 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1274
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1275 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1329
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1330 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1382
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1383 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1438
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1439 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1498
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1499 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1556
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1612
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1613 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1664
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1665 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1723
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1724 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1765 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1816
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1877 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 1989 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 2039
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 2040 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2077
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2078 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2134
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2174
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2175 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2229
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2230 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2278
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2279 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2328
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2329 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2375
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2376 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2433
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2434 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2486
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2487 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2597
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2598 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2653 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2700
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 419 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 475
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 476 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 528
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 529 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 585
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 586 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 640
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 641 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 698
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 699 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 755
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 756 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 815
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 816 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 875
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 876 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 933
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 934 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 989
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 990 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1045
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1099
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1214
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1334
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1335 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1394
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1395 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1454
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1455 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1514
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1515 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1574
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1575 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1634
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1694
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1695 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1744
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1745 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1804
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 1918 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 1976
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2034
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 2035 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2092
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2153 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2203
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2204 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2258
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2259 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2313
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2314 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2363
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2364 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2421 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2478
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2534
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2535 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2592
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2593 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2619
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1259
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1319
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1436
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1496
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1497 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1556
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1729
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1730 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1778
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1829
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1830 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1869
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1870 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1916
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1917 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1970 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 2020
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2074
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2131
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2252 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2309 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2368
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2427
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2428 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2478
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2533
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2534 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2588
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2589 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2639
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2640 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2691
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2692 S-AEELQRLAQGHTTVDELA 2710
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1169 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1221
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1222 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1281
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1282 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1341
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1342 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1388
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1443
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1444 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1503
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1624 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1678 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1731
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1732 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1781 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1840
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1841 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 1899
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 1900 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1959
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 1960 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2137 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2196
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2317 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2356
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2357 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2416
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2417 AEMSR 2421
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 1006 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1053
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1054 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1111
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1112 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1170
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1171 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1212
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1213 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1268
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1269 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1321
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1322 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1381
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1382 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1441
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1442 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1560
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1561 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1615
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1616 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1673
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1734 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1792
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1793 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1844
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1845 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1894
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1895 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1939
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1940 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1972
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2090
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2091 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2133
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2134 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2188
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2189 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2241
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2242 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2301
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2302 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2353
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2354 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2394
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2395 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2448
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2449 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2490
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2491 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2532
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2533 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2583
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2584 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2618
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2619 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2672
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2673 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2729
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2730 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2760
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1159
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1219
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1220 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1278
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1279 QALLEEIE 1286
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 982 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 1039
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 1040 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1099
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1100 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1159
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1160 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1219
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1220 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1276
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1277 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1316
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1317 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1375
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1436 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1546
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1547 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1606
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1607 SKRASFAEKTAQLERSL 1623
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 263 bits (672), Expect = 6e-69
Identities = 594/2890 (20%), Positives = 1115/2890 (38%), Gaps = 516/2890 (17%)
Query: 17 VMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLP 76
V ++ +DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP
Sbjct: 18 VREKYKDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLP 75
Query: 77 CEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTI 136
E+GR R H + N+ AL +L R+ +KLVNI + DIADG P + LGL+WTI
Sbjct: 76 REKGRM--RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDIADGNPKLTLGLIWTI 126
Query: 137 ILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQ 196
IL+FQI ++ S S D AK+ LL W Q
Sbjct: 127 ILHFQISDI----------QVSGQSEDM---------------------TAKEKLLLWSQ 155
Query: 197 YTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETE 256
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +
Sbjct: 156 RMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERD 215
Query: 257 LGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSV 316
LG+ RLLDPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 216 LGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELV 274
Query: 317 QNF------------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKH 360
+R F+E+++ QF E +L + ++ + YQS +
Sbjct: 275 LLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEG 334
Query: 361 FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGT 420
++K H + GKL + L ++ R + ++ L G
Sbjct: 335 AVQAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGL 393
Query: 421 IGAWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QN 462
L +A+ L+ ++ + + + A ++R L++ ++ Q
Sbjct: 394 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 453
Query: 463 TDAHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFL 513
++R + HE Y R G+ P Q+ V+ S ++E
Sbjct: 454 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDS 506
Query: 514 ELKYRLLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFE 561
L+Y L LL E L S + G + Q ++ + + IE ++ E
Sbjct: 507 TLRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDE 565
Query: 562 QYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-- 615
Q+ T Y G ++ K +N + A+ R+L S + + ++
Sbjct: 566 G-----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 618
Query: 616 -----EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPH 659
EEV +W DR N A +++ LE EK + + +NA R P
Sbjct: 619 NEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPT 678
Query: 660 WIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKE 719
A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 679 VESFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ-------- 723
Query: 720 YTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHL 779
L +K S + ++ L+QD +D ++++ + K A
Sbjct: 724 -------LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKA 776
Query: 780 ITKESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQM 831
+ + P+ M + +++ + K EC QL+ P + ++
Sbjct: 777 VVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKV 827
Query: 832 TSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVT 891
S S + + ++ Q + ++ +T +E Q++ VT
Sbjct: 828 LSSSGSEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VT 867
Query: 892 LSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLR 951
L + L H D L +A+QS+ + + R +K EE R L +
Sbjct: 868 LWHQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLEL 917
Query: 952 IAQEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQE 1006
Q L + D PE+ L E+ S C L + +QG QE
Sbjct: 918 HYQAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQE 964
Query: 1007 AVR--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ 1058
R + + KD LQ EA H L L +D E R EC + + K +
Sbjct: 965 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAE 1018
Query: 1059 -EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
EG K + RL E + LP P T LR+
Sbjct: 1019 VEGLGKGV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRS 1051
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANH 1167
++ T KL + Y + S + +E QLK +
Sbjct: 1052 ELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPEL 1111
Query: 1168 GEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLS 1218
K +++++R + T L+ L+ EV + E ++ + +A+L
Sbjct: 1112 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1171
Query: 1219 SSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDT 1272
++A++ ++ L G ++Y + L + ++ QEQ A+
Sbjct: 1172 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVR 1231
Query: 1273 ENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL------------------- 1313
E L + Q LL ++ +++ +R +Q I + E L
Sbjct: 1232 EQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKV 1291
Query: 1314 ---PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSH 1370
+ +E L + L + + I TLR+ E E E Q
Sbjct: 1292 QSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEER 1345
Query: 1371 ERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQ 1425
ER L + + LE+ ++ ++ QAE KE E+ + QQ
Sbjct: 1346 ER------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ 1399
Query: 1426 QAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSA 1485
Q +SI+E++++L + E +I+ + E I +L A E
Sbjct: 1400 QKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGG 1456
Query: 1486 MDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEE 1542
+ ++ ++ +E E++ +EEA+ + V + +A++ ++++ E
Sbjct: 1457 AEGELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEA 1513
Query: 1543 LREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEH 1602
RE + L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1514 AREKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA------- 1562
Query: 1603 MDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------ 1656
L S +F+ ++ S +E A+ Q E+ RRA+++ A
Sbjct: 1563 --------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1612
Query: 1657 LENLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQ 1707
E L WQ RL+ E + L + EA+ E + A R G+ +
Sbjct: 1613 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQA 1669
Query: 1708 ALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFL 1767
Q E+ Q + L + +A++ ++ ++ EQ +++ + L + + +
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729
Query: 1768 QSVVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE- 1819
+ + Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 1820 ------VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAED 1855
E K + Q + A KL ++G A ++ L + +AE+
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 1856 CFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKD 1915
E ++ E L E H + I +L Q +A++S + + L+E
Sbjct: 1850 -----ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDT 1902
Query: 1916 LNDALQNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLC 1963
L Q + + + S + KA+ L++G S EQ A QL
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 1964 GEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQ 2022
E ER + ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q
Sbjct: 1963 AEEERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESA 2019
Query: 2023 QRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIH 2082
++L++ + K Q +K AFA V ++ L+ T + ++
Sbjct: 2020 RQLQLAQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLD 2063
Query: 2083 ENQGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNK 2141
+ +G+ E + + A + ++ V + E+ A ++ + A K
Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 2142 MNYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRV 2201
+ + + ++ + K+ ++ K E T L ++E+ + LR+
Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRL 2179
Query: 2202 SLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKA 2255
L D + DE + A S ++ L + EEL K + E +N+A
Sbjct: 2180 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2239
Query: 2256 LRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQ 2315
L L + K N + L + E + A L + A + ++A+ +D Q
Sbjct: 2240 LILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRAL 2293
Query: 2316 VEKFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENL 2370
EK + + V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2294 AEKMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2350
Query: 2371 NSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL 2430
+LE A ++ E S+ QA +E ++ F + +E E
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLH 2404
Query: 2431 GAKAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIV 2489
+ A +E ++ + HD + + +++++ + + + + QE + L L + +
Sbjct: 2405 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEM 2462
Query: 2490 SSIQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTE 2548
++Q++ Q L++ QALQ SE S + R + ++E+ F E
Sbjct: 2463 QTVQQE-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2509
Query: 2549 NLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQL 2608
+ +++Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2510 -VAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------- 2557
Query: 2609 LTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLE 2668
L ++ +++ + ++ +E++ L E LQ + +A LA +E S+
Sbjct: 2558 -----ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAAT 2609
Query: 2669 KRLSQIQDIL 2678
K L +D L
Sbjct: 2610 KTLPNGRDAL 2619
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 235 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 294
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 295 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 337
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 338 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 386
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 387 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 444 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 500
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 501 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 557
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 558 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 609
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 610 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 667
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 668 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 725
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 726 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 785
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 786 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 840
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 841 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 900
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 901 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 960
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 961 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1015
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1016 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1073
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1134 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1254 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1311
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1312 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1367
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1368 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1405
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1450
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1451 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1500
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1501 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1555
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1556 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1615
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1616 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1656
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1710
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1711 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1767
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1820
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1875
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1876 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1977
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1978 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2036
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2037 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2094 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2151
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2152 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2211
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2272 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2328
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2383
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2384 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2429
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2430 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2470
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2471 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2564
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1122 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1168
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1169 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1220
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1221 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1279
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1395
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1511
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1691
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1692 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1743
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1744 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1801
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1802 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1861
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1862 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1982 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2030
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2091 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2125
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2126 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2234
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2235 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2293
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2294 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2349
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2350 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2392
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2442
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2496
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2497 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2552
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2553 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2609
Query: 6335 ALLP 6338
LP
Sbjct: 2610 KTLP 2613
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 533 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 587
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 588 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 643
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 644 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 682
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 683 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 721
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 722 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 761
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 762 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 818
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 819 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 871
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 872 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 931
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 932 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 990
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 991 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1049
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1050 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1097
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1098 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1150
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1151 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1210
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1267
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1268 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1327
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1328 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1387
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1388 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1442
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1443 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1503 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1557
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1558 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1607
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1608 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1667
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1668 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1726 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1767
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1768 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1820
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1821 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 1881 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 1931
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 1989
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 1990 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2040
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2100
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2101 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2160
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2161 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2212
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2213 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2332 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2384
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2385 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2442
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2443 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2488
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2489 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2513
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1130
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1131 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1190
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1191 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1250
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1251 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1310
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1311 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1370 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1426
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1427 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1474
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1475 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1528
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1585
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1822
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1877
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2058 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2217
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2218 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2247
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2248 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2307
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2308 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2414 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2474 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2508
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2568
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2569 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2619
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 964 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 1014
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1070
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1126
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1127 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1185
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1186 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1233
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1234 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1288
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1289 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1341
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1342 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1397
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1398 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1457
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1458 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1515
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1571
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1572 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1623
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1624 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1682
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1683 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1724 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1775
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1836 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 1948 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 1998
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 1999 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2036
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2037 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2093
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2133
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2134 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2188
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2189 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2237
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2238 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2287
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2288 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2334
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2335 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2392
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2393 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2445
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2446 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2556
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2557 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2612 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2659
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 378 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 434
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 435 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 487
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 488 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 544
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 545 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 599
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 600 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 657
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 658 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 714
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 715 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 774
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 775 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 834
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 835 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 892
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 893 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 948
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 949 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1004
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1005 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1058
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1173
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1293
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1294 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1353
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1354 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1413
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1414 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1473
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1474 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1533
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1534 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1593
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1653
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1654 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1703
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1704 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1763
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 1877 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 1935
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1993
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 1994 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2051
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2112 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2162
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2163 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2217
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2218 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2272
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2273 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2322
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2323 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2380 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2437
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2493
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2494 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2551
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2552 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2578
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1159 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1218
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1219 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1278
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1395
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1455
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1456 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1515
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1688
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1689 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1737
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1788
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1789 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1828
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1829 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1875
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1876 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1929 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1979
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2033
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2090
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2211 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2267
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2268 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2327
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2386
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2387 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2437
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2492
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2493 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2547
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2548 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2598
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2599 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2650
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2651 S-AEELQRLAQGHTTVDELA 2669
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1128 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1180
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1181 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1240
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1241 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1300
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1347
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1348 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1402
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1462
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1583 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1637 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1690
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1691 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1799
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1800 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 1858
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 1859 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1918
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 1919 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2096 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2155
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2276 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2315
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2316 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2375
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2376 AEMSR 2380
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 965 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1012
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1013 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1070
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1071 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1129
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1130 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1171
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1172 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1227
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1228 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1280
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1281 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1340
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1341 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1400
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1401 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1519
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1520 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1574
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1575 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1632
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1693 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1751
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1752 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1803
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1804 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1853
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1854 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1898
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1899 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1931
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2049
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2050 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2092
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2093 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2147
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2148 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2200
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2201 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2260
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2261 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2312
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2313 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2353
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2354 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2407
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2408 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2449
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2450 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2491
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2492 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2542
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2543 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2577
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2578 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2631
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2632 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2688
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2689 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2719
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1118
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1237
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1238 QALLEEIE 1245
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 941 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 998
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 999 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1058
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1059 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1118
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1119 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1178
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1179 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1235
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1236 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1275
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1276 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1334
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1395 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1505
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1506 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1565
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1566 SKRASFAEKTAQLERSL 1582
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 262 bits (670), Expect = 1e-68
Identities = 594/2885 (20%), Positives = 1112/2885 (38%), Gaps = 516/2885 (17%)
Query: 22 QDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGR 81
QDE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 37 QDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94
Query: 82 RMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQ 141
R H + N+ AL +L R+ +KLVNI + DIADG P + LGL+WTIIL+FQ
Sbjct: 95 M--RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 145
Query: 142 IEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGK 201
I ++ S S D AK+ LL W Q
Sbjct: 146 ISDI----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEG 174
Query: 202 QTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPR 261
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ R
Sbjct: 175 YQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTR 234
Query: 262 LLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF-- 319
LLDPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 235 LLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQ 293
Query: 320 ----------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQY 365
+R F+E+++ QF E +L + ++ + YQS +
Sbjct: 294 WMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAG 353
Query: 366 EMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWL 425
++K H + GKL + L ++ R + ++ L G L
Sbjct: 354 QLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQL 412
Query: 426 YRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHK 467
+A+ L+ ++ + + + A ++R L++ ++ Q ++
Sbjct: 413 NQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYR 472
Query: 468 RAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYR 518
R + HE Y R G+ P Q+ V+ S ++E L+Y
Sbjct: 473 RVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY- 524
Query: 519 LLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVT 566
L LL E L S + G + Q ++ + + IE ++ E
Sbjct: 525 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---- 580
Query: 567 YQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML------- 615
Q+ T Y G ++ K +N + A+ R+L S + + ++
Sbjct: 581 -QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637
Query: 616 EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQH 664
EEV +W DR N A +++ LE EK + + +NA R P
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 665 TAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCV 724
A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 698 AALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ------------- 737
Query: 725 VTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES 784
L +K S + ++ L+QD +D ++++ + K A + +
Sbjct: 738 --LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 795
Query: 785 PQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYD 836
P+ M + +++ + K EC QL+ P + ++ S
Sbjct: 796 PRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSG 846
Query: 837 SLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVL 896
S + + ++ Q + ++ +T +E Q++ VTL + L
Sbjct: 847 SEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL 886
Query: 897 KHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEG 956
H D L +A+QS+ + + R +K EE R L + Q
Sbjct: 887 -HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAF 936
Query: 957 LEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR-- 1009
L + D PE+ L E+ S C L + +QG QE R
Sbjct: 937 LRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQ 983
Query: 1010 KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSE 1062
+ + KD LQ EA H L L +D E R EC + + K + EG
Sbjct: 984 RCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLG 1037
Query: 1063 KIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST 1122
K + RL E + LP P T LR+ ++ T
Sbjct: 1038 KGV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELT 1070
Query: 1123 YRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKR 1172
KL + Y + S + +E QLK + K
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1130
Query: 1173 AVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKA 1223
+++++R + T L+ L+ EV + E ++ + +A+L ++A
Sbjct: 1131 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 1224 LVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFE 1277
++ ++ L G ++Y + L + ++ QEQ A+ E L +
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 1278 AQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PD 1315
Q LL ++ +++ +R +Q I + E L +
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 1316 RGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLS 1375
+E L + L + + I TLR+ E E E Q ER
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER--- 1361
Query: 1376 FSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSI 1430
L + + LE+ ++ ++ QAE KE E+ + QQQ +SI
Sbjct: 1362 ---LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 1431 KEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQI 1490
+E++++L + E +I+ + E I +L A E + ++
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGEL 1475
Query: 1491 SQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHA 1547
++ +E E++ +EEA+ + V + +A++ ++++ E RE
Sbjct: 1476 QALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 1548 QCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1607
+ L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1533 RALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA------------ 1576
Query: 1608 ALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLL 1661
L S +F+ ++ S +E A+ Q E+ RRA+++ A E L
Sbjct: 1577 ---ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 1662 AHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE 1712
WQ RL+ E + L + EA+ E + A R G+ + Q E
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRE 1688
Query: 1713 VVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
+ Q + L + +A++ ++ ++ EQ +++ + L + + + +
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 1773 EHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE------ 1819
+ Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1808
Query: 1820 -VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLF 1860
E K + Q + A KL ++G A ++ L + +AE+
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN----- 1863
Query: 1861 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1920
E ++ E L E H + I +L Q +A++S + + L+E L
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 1921 QNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVER 1968
Q + + + S + KA+ L++G S EQ A QL E ER
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 1969 IQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRV 2027
+ ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++
Sbjct: 1982 RRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 2028 FNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQ 2087
+ K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2039 AQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 2088 CCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQ 2146
E + + A + ++ V + E+ A ++ + A K+ +
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 2147 KDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIW 2206
+ ++ + K+ ++ K E T L ++E+ + LR+ L
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEET 2198
Query: 2207 DDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEE 2260
D + DE + A S ++ L + EEL K + E +N+AL L +
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 2261 LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFI 2320
K N + L + E + A L + A + ++A+ +D Q EK +
Sbjct: 2259 ---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKML 2312
Query: 2321 NDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCR 2375
+ V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2313 KE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 2376 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAA 2435
+LE A ++ E S+ QA +E ++ F + +E E + A
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELA 2423
Query: 2436 AKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE 2494
+E ++ + HD + + +++++ + + + + QE + L L + + ++Q+
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQ 2481
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGES 2553
+ Q L++ QALQ SE S + R + ++E+ F E + ++
Sbjct: 2482 E-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKA 2527
Query: 2554 KQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQ 2613
+Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ 2571
Query: 2614 NLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ 2673
L ++ +++ + ++ +E++ L E LQ + +A LA +E S+ K L
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPN 2628
Query: 2674 IQDIL 2678
+D L
Sbjct: 2629 GRDAL 2633
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 249 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 308
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 309 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 351
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 352 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 400
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 401 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 514
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 515 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 571
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 572 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 623
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 624 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 681
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 682 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 739
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 800 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 854
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 855 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 975 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1029
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1030 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1268 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1381
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1419
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1464
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1465 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1514
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1515 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1569
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1630 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1670
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1724
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1781
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1834
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1889
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1890 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2050
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2051 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2108 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2286 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2397
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2398 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2443
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2444 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2484
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2485 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1136 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1182
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1183 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1235 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1525
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1706 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1757
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1815
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1996 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2044
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2105 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2139
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2140 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2248
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2249 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2308 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2363
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2364 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2406
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2456
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2511 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2566
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2623
Query: 6335 ALLP 6338
LP
Sbjct: 2624 KTLP 2627
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 547 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 601
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 602 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 658 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 696
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 697 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 735
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 736 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 775
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 776 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 832
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 833 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 885
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 886 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 945
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 946 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1004
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1063
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1111
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1112 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1281
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1402 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1456
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1517 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1621
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1740 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1781
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1782 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1834
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 1895 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 1945
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 2004 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2226
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2346 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2398
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2456
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2457 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2503 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2527
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1384 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1441 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1488
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1489 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1542
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1599
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1836
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1891
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2072 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2231
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2232 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2261
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2322 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2488 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2522
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 978 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 1028
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1084
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1141 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1200 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1247
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1248 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1302
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1303 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1355
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1356 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1412 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1472 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1529
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1585
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1586 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1696
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1697 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1738 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1789
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1850 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 2013 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2050
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2051 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2107
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2147
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2148 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2202
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2203 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2252 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2301
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2302 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2348
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2349 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2407 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2460 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2570
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2571 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2626 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 392 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 448
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 449 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 501
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 502 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 558
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 613
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 614 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 671
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 672 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 728
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 729 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 789 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 849 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 906
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 907 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 962
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 963 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1018
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1072
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1187
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1717
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 1949
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2065
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2126 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2177 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2231
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2232 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2287 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2337 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2394 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2451
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2507
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2508 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2565
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2566 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2592
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1409
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1703 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1751
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1802
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1803 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1842
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1843 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1889
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1890 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1943 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2047
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2104
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2400
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2401 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2506
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2561
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2562 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2613 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2664
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2665 S-AEELQRLAQGHTTVDELA 2683
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1142 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1361
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1416
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1597 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1651 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1705 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 1872
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 1933 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2290 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2329
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2390 AEMSR 2394
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1026
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1084
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1143
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1185
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1186 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1294
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1534 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1588
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1589 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1646
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1707 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1817
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1818 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1867
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1868 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1912
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1913 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1945
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2063
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2064 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2161
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2214
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2275 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2326
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2367
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2368 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2421
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2422 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2463
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2464 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2505
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2506 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2556
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2557 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2591
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2645
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2702
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1132
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1251
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1252 QALLEEIE 1259
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 1012
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1249
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1250 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1348
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1409 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1519
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1580 SKRASFAEKTAQLERSL 1596
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 261 bits (668), Expect = 2e-68
Identities = 594/2889 (20%), Positives = 1114/2889 (38%), Gaps = 516/2889 (17%)
Query: 18 MQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPC 77
M+ + DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP
Sbjct: 1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPR 58
Query: 78 EQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTII 137
E+GR R H + N+ AL +L R+ +KLVNI + DIADG P + LGL+WTII
Sbjct: 59 EKGRM--RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDIADGNPKLTLGLIWTII 109
Query: 138 LYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQY 197
L+FQI ++ S S D AK+ LL W Q
Sbjct: 110 LHFQISDI----------QVSGQSEDM---------------------TAKEKLLLWSQR 138
Query: 198 TAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETEL 257
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +L
Sbjct: 139 MVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDL 198
Query: 258 GIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQ 317
G+ RLLDPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 199 GVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVL 257
Query: 318 NF------------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHF 361
+R F+E+++ QF E +L + ++ + YQS +
Sbjct: 258 LLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGA 317
Query: 362 RVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTI 421
++K H + GKL + L ++ R + ++ L G
Sbjct: 318 VQAGQLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLC 376
Query: 422 GAWLYRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNT 463
L +A+ L+ ++ + + + A ++R L++ ++ Q
Sbjct: 377 EEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGE 436
Query: 464 DAHKRAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLE 514
++R + HE Y R G+ P Q+ V+ S ++E
Sbjct: 437 QMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDST 489
Query: 515 LKYRLLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQ 562
L+Y L LL E L S + G + Q ++ + + IE ++ E
Sbjct: 490 LRY-LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG 548
Query: 563 YEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML--- 615
Q+ T Y G ++ K +N + A+ R+L S + + ++
Sbjct: 549 -----QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 601
Query: 616 ----EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHW 660
EEV +W DR N A +++ LE EK + + +NA R P
Sbjct: 602 EKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTV 661
Query: 661 IQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY 720
A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 662 ESFQAALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ--------- 705
Query: 721 TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLI 780
L +K S + ++ L+QD +D ++++ + K A +
Sbjct: 706 ------LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAV 759
Query: 781 TKESPQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMT 832
+ P+ M + +++ + K EC QL+ P + ++
Sbjct: 760 VQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVL 810
Query: 833 SFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTL 892
S S + + ++ Q + ++ +T +E Q++ VTL
Sbjct: 811 SSSGSEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTL 850
Query: 893 SNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRI 952
+ L H D L +A+QS+ + + R +K EE R L +
Sbjct: 851 WHQL-HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELH 900
Query: 953 AQEGLEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEA 1007
Q L + D PE+ L E+ S C L + +QG QE
Sbjct: 901 YQAFLRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEE 947
Query: 1008 VR--KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ- 1058
R + + KD LQ EA H L L +D E R EC + + K +
Sbjct: 948 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEV 1001
Query: 1059 EGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAA 1118
EG K + RL E + LP P T LR+
Sbjct: 1002 EGLGKGV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSE 1034
Query: 1119 IDSTYRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHG 1168
++ T KL + Y + S + +E QLK +
Sbjct: 1035 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1094
Query: 1169 EVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSS 1219
K +++++R + T L+ L+ EV + E ++ + +A+L
Sbjct: 1095 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1154
Query: 1220 SFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTE 1273
++A++ ++ L G ++Y + L + ++ QEQ A+ E
Sbjct: 1155 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1214
Query: 1274 NLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL-------------------- 1313
L + Q LL ++ +++ +R +Q I + E L
Sbjct: 1215 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1274
Query: 1314 --PDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHE 1371
+ +E L + L + + I TLR+ E E E Q E
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERE 1328
Query: 1372 RFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQ 1426
R L + + LE+ ++ ++ QAE KE E+ + QQQ
Sbjct: 1329 R------LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Query: 1427 AKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAM 1486
+SI+E++++L + E +I+ + E I +L A E
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGA 1439
Query: 1487 DMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEEL 1543
+ ++ ++ +E E++ +EEA+ + V + +A++ ++++ E
Sbjct: 1440 EGELQALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1496
Query: 1544 REHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHM 1603
RE + L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1497 REKQRALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA-------- 1544
Query: 1604 DLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------L 1657
L S +F+ ++ S +E A+ Q E+ RRA+++ A
Sbjct: 1545 -------ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Query: 1658 ENLLAHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQA 1708
E L WQ RL+ E + L + EA+ E + A R G+ +
Sbjct: 1596 ERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAV 1652
Query: 1709 LQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQ 1768
Q E+ Q + L + +A++ ++ ++ EQ +++ + L + + +
Sbjct: 1653 RQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA 1712
Query: 1769 SVVAEHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE-- 1819
+ + Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1713 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1772
Query: 1820 -----VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDC 1856
E K + Q + A KL ++G A ++ L + +AE+
Sbjct: 1773 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN- 1831
Query: 1857 FQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDL 1916
E ++ E L E H + I +L Q +A++S + + L+E L
Sbjct: 1832 ----ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTL 1885
Query: 1917 NDALQNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCG 1964
Q + + + S + KA+ L++G S EQ A QL
Sbjct: 1886 RQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1945
Query: 1965 EVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQ 2023
E ER + ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q +
Sbjct: 1946 EEERRRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESAR 2002
Query: 2024 RLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHE 2083
+L++ + K Q +K AFA V ++ L+ T + ++ +
Sbjct: 2003 QLQLAQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQ 2046
Query: 2084 NQGQCCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKM 2142
+G+ E + + A + ++ V + E+ A ++ + A K+
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106
Query: 2143 NYKQKDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVS 2202
+ + ++ + K+ ++ K E T L ++E+ + LR+
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQ 2162
Query: 2203 LSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKAL 2256
L D + DE + A S ++ L + EEL K + E +N+AL
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 2257 RLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQV 2316
L + K N + L + E + A L + A + ++A+ +D Q
Sbjct: 2223 ILRD---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALA 2276
Query: 2317 EKFINDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLN 2371
EK + + V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2277 EKMLKE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQ 2333
Query: 2372 SLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLG 2431
+LE A ++ E S+ QA +E ++ F + +E E
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHR 2387
Query: 2432 AKAAAKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVS 2490
+ A +E ++ + HD + + +++++ + + + + QE + L L + +
Sbjct: 2388 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQ 2445
Query: 2491 SIQEQITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTEN 2549
++Q++ Q L++ QALQ SE S + R + ++E+ F E
Sbjct: 2446 TVQQE-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE- 2491
Query: 2550 LGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLL 2609
+ +++Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2492 VAKAQQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE-------- 2539
Query: 2610 TSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
L ++ +++ + ++ +E++ L E LQ + +A LA +E S+ K
Sbjct: 2540 ----ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATK 2592
Query: 2670 RLSQIQDIL 2678
L +D L
Sbjct: 2593 TLPNGRDAL 2601
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 217 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 276
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 277 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 319
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 320 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 368
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 369 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 425
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 426 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 482
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 483 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 539
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 540 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 591
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 592 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 649
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 650 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 707
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 708 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 767
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 768 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 822
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 823 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 882
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 883 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 942
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 943 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 997
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 998 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1055
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1116 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1236 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1293
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1294 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1349
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1350 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1387
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1432
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1433 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1482
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1483 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1537
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1538 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1598 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1638
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1692
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1693 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1749
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1802
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1857
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1858 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2018
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2019 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2076 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2133
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2134 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2193
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2254 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2310
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2365
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2366 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2411
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2412 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2452
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2453 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2546
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1104 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1150
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1151 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1202
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1203 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1261
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1377
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1493
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1673
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1674 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1725
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1726 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1783
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1784 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1843
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1844 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1964 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2012
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2073 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2107
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2108 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2216
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2217 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2275
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2276 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2331
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2332 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2374
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2424
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2478
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2479 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2534
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2535 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2591
Query: 6335 ALLP 6338
LP
Sbjct: 2592 KTLP 2595
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 515 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 569
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 570 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 625
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 626 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 664
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 665 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 703
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 704 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 743
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 744 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 800
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 801 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 853
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 854 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 913
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 914 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 972
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 973 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1031
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1032 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1079
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1080 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1132
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1133 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1192
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1193 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1249
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1250 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1309
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1310 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1369
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1370 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1424
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1485 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1539
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1540 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1589
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1649
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1708 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1749
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1750 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1802
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1803 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 1863 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 1913
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 1971
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 1972 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2022
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2082
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2083 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2142
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2143 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2194
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2195 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2314 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2366
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2367 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2424
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2425 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2471 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2495
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1112
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1113 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1172
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1173 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1232
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1233 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1292
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1293 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1352 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1408
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1409 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1456
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1457 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1510
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1567
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1804
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1859
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2040 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2199
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2200 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2229
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2230 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2289
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2290 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2396 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2456 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2490
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2550
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2551 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2601
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 946 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 996
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 997 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1052
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1108
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1109 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1167
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1168 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1215
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1216 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1270
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1271 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1323
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1324 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1379
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1380 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1439
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1440 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1497
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1553
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1554 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1605
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1606 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1664
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1665 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1706 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1757
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1818 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 1930 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 1980
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 1981 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2018
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2019 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2075
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2115
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2116 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2170
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2171 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2219
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2220 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2269
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2270 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2316
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2317 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2374
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2375 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2428 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2538
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2539 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2594 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2641
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 360 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 416
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 417 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 469
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 470 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 526
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 527 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 581
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 582 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 639
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 640 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 696
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 697 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 756
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 757 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 816
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 817 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 874
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 875 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 930
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 931 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 986
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 987 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1040
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1155
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1275
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1335
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1336 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1395
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1396 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1455
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1456 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1515
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1516 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1575
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1635
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1636 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1685
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1686 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1745
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 1859 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 1917
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1975
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 1976 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2033
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2094 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2144
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2145 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2199
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2200 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2254
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2255 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2305 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2362 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2419
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2475
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2476 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2533
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2534 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2560
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1141 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1200
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1201 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1260
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1377
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1437
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1438 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1497
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1670
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1671 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1719
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1770
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1771 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1810
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1811 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1857
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1858 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1911 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1961
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2015
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2072
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2193 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2249
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2250 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2309
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2368
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2369 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2419
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2474
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2475 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2529
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2530 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2580
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2581 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2632
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2633 S-AEELQRLAQGHTTVDELA 2651
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1110 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1162
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1163 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1222
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1223 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1282
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1329
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1384
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1385 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1444
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1565 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1619 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1672
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1673 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1781
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1782 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 1840
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 1841 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1900
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 1901 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2078 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2137
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2258 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2297
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2298 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2357
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2358 AEMSR 2362
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 947 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 994
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 995 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1052
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1053 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1111
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1112 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1153
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1154 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1209
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1210 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1262
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1263 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1322
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1323 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1382
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1501
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1502 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1556
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1557 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1614
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1675 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1785
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1786 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1835
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1836 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1880
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1881 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1913
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2031
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2032 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2074
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2075 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2129
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2130 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2182
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2183 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2242
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2243 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2294
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2295 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2335
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2336 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2389
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2390 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2431
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2432 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2473
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2474 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2524
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2525 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2559
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2560 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2613
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2614 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2670
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2671 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2701
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1100
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1160
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1161 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1219
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1220 QALLEEIE 1227
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 923 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 980
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 981 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1040
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1041 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1100
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1101 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1160
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1161 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1217
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1218 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1257
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1258 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1316
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1377 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1487
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1488 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1547
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1548 SKRASFAEKTAQLERSL 1564
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 261 bits (666), Expect = 3e-68
Identities = 593/2885 (20%), Positives = 1112/2885 (38%), Gaps = 516/2885 (17%)
Query: 22 QDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGR 81
+DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 37 KDERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGR 94
Query: 82 RMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQ 141
R H + N+ AL +L R+ +KLVNI + DIADG P + LGL+WTIIL+FQ
Sbjct: 95 M--RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 145
Query: 142 IEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGK 201
I ++ S S D AK+ LL W Q
Sbjct: 146 ISDI----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEG 174
Query: 202 QTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPR 261
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ R
Sbjct: 175 YQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTR 234
Query: 262 LLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF-- 319
LLDPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 235 LLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQ 293
Query: 320 ----------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQY 365
+R F+E+++ QF E +L + ++ + YQS +
Sbjct: 294 WMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAG 353
Query: 366 EMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWL 425
++K H + GKL + L ++ R + ++ L G L
Sbjct: 354 QLKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQL 412
Query: 426 YRAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHK 467
+A+ L+ ++ + + + A ++R L++ ++ Q ++
Sbjct: 413 NQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYR 472
Query: 468 RAF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYR 518
R + HE Y R G+ P Q+ V+ S ++E L+Y
Sbjct: 473 RVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY- 524
Query: 519 LLSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVT 566
L LL E L S + G + Q ++ + + IE ++ E
Sbjct: 525 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---- 580
Query: 567 YQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML------- 615
Q+ T Y G ++ K +N + A+ R+L S + + ++
Sbjct: 581 -QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637
Query: 616 EEVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQH 664
EEV +W DR N A +++ LE EK + + +NA R P
Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697
Query: 665 TAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCV 724
A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 698 AALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ------------- 737
Query: 725 VTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKES 784
L +K S + ++ L+QD +D ++++ + K A + +
Sbjct: 738 --LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 795
Query: 785 PQEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYD 836
P+ M + +++ + K EC QL+ P + ++ S
Sbjct: 796 PRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSG 846
Query: 837 SLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVL 896
S + + ++ Q + ++ +T +E Q++ VTL + L
Sbjct: 847 SEAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL 886
Query: 897 KHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEG 956
H D L +A+QS+ + + R +K EE R L + Q
Sbjct: 887 -HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAF 936
Query: 957 LEEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR-- 1009
L + D PE+ L E+ S C L + +QG QE R
Sbjct: 937 LRDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQ 983
Query: 1010 KLHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSE 1062
+ + KD LQ EA H L L +D E R EC + + K + EG
Sbjct: 984 RCISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLG 1037
Query: 1063 KIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDST 1122
K + RL E + LP P T LR+ ++ T
Sbjct: 1038 KGV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELT 1070
Query: 1123 YRKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKR 1172
KL + Y + S + +E QLK + K
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1130
Query: 1173 AVEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKA 1223
+++++R + T L+ L+ EV + E ++ + +A+L ++A
Sbjct: 1131 SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQA 1190
Query: 1224 LVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFE 1277
++ ++ L G ++Y + L + ++ QEQ A+ E L +
Sbjct: 1191 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1250
Query: 1278 AQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PD 1315
Q LL ++ +++ +R +Q I + E L +
Sbjct: 1251 EQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSE 1310
Query: 1316 RGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLS 1375
+E L + L + + I TLR+ E E E Q ER
Sbjct: 1311 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER--- 1361
Query: 1376 FSSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSI 1430
L + + LE+ ++ ++ QAE KE E+ + QQQ +SI
Sbjct: 1362 ---LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 1431 KEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQI 1490
+E++++L + E +I+ + E I +L A E + ++
Sbjct: 1419 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGEL 1475
Query: 1491 SQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHA 1547
++ +E E++ +EEA+ + V + +A++ ++++ E RE
Sbjct: 1476 QALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 1548 QCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1607
+ L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1533 RALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA------------ 1576
Query: 1608 ALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLL 1661
L S +F+ ++ S +E A+ Q E+ RRA+++ A E L
Sbjct: 1577 ---ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL 1631
Query: 1662 AHWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNE 1712
WQ RL+ E + L + EA+ E + A R G+ + Q E
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQRE 1688
Query: 1713 VVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVA 1772
+ Q + L + +A++ ++ ++ EQ +++ + L + + + +
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQ 1748
Query: 1773 EHQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE------ 1819
+ Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1808
Query: 1820 -VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLF 1860
E K + Q + A KL ++G A ++ L + +AE+
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN----- 1863
Query: 1861 EEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDAL 1920
E ++ E L E H + I +L Q +A++S + + L+E L
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRR 1921
Query: 1921 QNAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVER 1968
Q + + + S + KA+ L++G S EQ A QL E ER
Sbjct: 1922 QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER 1981
Query: 1969 IQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRV 2027
+ ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++
Sbjct: 1982 RRR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 2028 FNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQ 2087
+ K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2039 AQE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGE 2082
Query: 2088 CCGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQ 2146
E + + A + ++ V + E+ A ++ + A K+ +
Sbjct: 2083 AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 2147 KDLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIW 2206
+ ++ + K+ ++ K E T L ++E+ + LR+ L
Sbjct: 2143 EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEET 2198
Query: 2207 DDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEE 2260
D + DE + A S ++ L + EEL K + E +N+AL L +
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 2261 LHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFI 2320
K N + L + E + A L + A + ++A+ +D Q EK +
Sbjct: 2259 ---KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKML 2312
Query: 2321 NDITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCR 2375
+ V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2313 KE---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE 2369
Query: 2376 KYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAA 2435
+LE A ++ E S+ QA +E ++ F + +E E + A
Sbjct: 2370 AERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELA 2423
Query: 2436 AKESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQE 2494
+E ++ + HD + + +++++ + + + + QE + L L + + ++Q+
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQ 2481
Query: 2495 QITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGES 2553
+ Q L++ QALQ SE S + R + ++E+ F E + ++
Sbjct: 2482 E-------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKA 2527
Query: 2554 KQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQ 2613
+Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------ 2571
Query: 2614 NLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQ 2673
L ++ +++ + ++ +E++ L E LQ + +A LA +E S+ K L
Sbjct: 2572 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPN 2628
Query: 2674 IQDIL 2678
+D L
Sbjct: 2629 GRDAL 2633
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 249 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 308
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 309 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 351
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 352 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 400
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 401 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 514
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 515 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 571
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 572 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 623
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 624 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 681
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 682 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 739
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 799
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 800 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 854
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 855 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 914
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 915 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 974
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 975 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1029
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1030 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1087
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1268 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1325
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1326 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1381
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1419
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1464
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1465 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1514
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1515 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1569
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1570 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1630 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1670
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1724
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1725 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1781
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1834
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1889
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1890 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2050
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2051 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2108 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2165
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2166 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2225
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2286 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2342
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2397
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2398 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2443
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2444 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2484
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2485 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2578
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1136 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1182
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1183 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1234
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1235 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1293
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1409
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1525
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1705
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1706 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1757
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1758 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1815
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1816 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1875
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1876 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 1996 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2044
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2105 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2139
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2140 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2248
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2249 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2307
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2308 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2363
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2364 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2406
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2456
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2510
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2511 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2566
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2567 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2623
Query: 6335 ALLP 6338
LP
Sbjct: 2624 KTLP 2627
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 547 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 601
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 602 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 657
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 658 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 696
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 697 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 735
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 736 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 775
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 776 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 832
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 833 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 885
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 886 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 945
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 946 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1004
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1005 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1063
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1064 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1111
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1112 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1225 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1281
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1282 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1341
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1342 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1401
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1402 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1456
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1517 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1571
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1572 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1621
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1740 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1781
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1782 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1834
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1835 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 1895 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 1945
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 2004 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2054
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2114
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2115 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2174
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2175 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2226
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2227 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2346 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2398
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2399 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2456
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2457 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2503 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2527
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1144
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1145 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1204
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1205 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1264
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1265 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1324
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1325 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1384 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1441 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1488
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1489 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1542
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1599
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1836
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1891
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2072 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2231
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2232 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2261
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2262 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2321
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2322 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2428 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2488 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2522
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2582
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2583 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 978 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 1028
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1084
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1140
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1141 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1200 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1247
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1248 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1302
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1303 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1355
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1356 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1412 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1471
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1472 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1529
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1585
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1586 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1637
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1638 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1696
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1697 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1738 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1789
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1850 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 1962 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 2013 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2050
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2051 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2107
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2147
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2148 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2202
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2203 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2251
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2252 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2301
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2302 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2348
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2349 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2406
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2407 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2460 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2570
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2571 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2626 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2673
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 392 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 448
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 449 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 501
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 502 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 558
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 559 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 613
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 614 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 671
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 672 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 728
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 729 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 788
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 789 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 848
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 849 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 906
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 907 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 962
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 963 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1018
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1072
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1187
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1368 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1427
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1428 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1487
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1488 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1547
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1548 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1607
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1667
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1668 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1717
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 1891 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 1949
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 2008 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2065
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2126 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2176
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2177 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2231
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2232 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2286
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2287 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2337 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2394 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2451
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2507
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2508 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2565
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2566 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2592
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1409
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1469
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1470 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1529
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1702
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1703 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1751
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1802
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1803 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1842
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1843 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1889
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1890 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1943 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2047
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2104
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2400
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2401 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2451
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2506
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2507 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2561
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2562 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2612
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2613 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2664
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2665 S-AEELQRLAQGHTTVDELA 2683
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1142 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1194
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1195 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1361
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1416
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1597 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1651 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1704
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1705 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 1872
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 1873 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1932
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 1933 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2110 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2290 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2329
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2389
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2390 AEMSR 2394
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 979 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1026
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1027 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1084
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1085 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1143
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1144 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1185
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1186 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1241
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1242 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1294
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1295 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1354
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1355 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1414
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1534 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1588
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1589 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1646
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1707 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1817
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1818 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1867
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1868 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1912
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1913 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1945
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2063
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2064 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2106
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2107 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2161
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2162 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2214
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2215 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2274
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2275 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2326
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2327 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2367
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2368 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2421
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2422 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2463
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2464 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2505
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2506 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2556
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2557 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2591
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2592 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2645
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2702
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2703 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2733
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1132
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1251
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1252 QALLEEIE 1259
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 955 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 1012
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 1013 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1072
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1073 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1132
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1133 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1192
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1193 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1249
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1250 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1290 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1348
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1409 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1519
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1580 SKRASFAEKTAQLERSL 1596
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 260 bits (665), Expect = 4e-68
Identities = 593/2884 (20%), Positives = 1111/2884 (38%), Gaps = 516/2884 (17%)
Query: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 42 DERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 99
Query: 83 MKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQI 142
R H + N+ AL +L R+ +KLVNI + DIADG P + LGL+WTIIL+FQI
Sbjct: 100 --RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDIADGNPKLTLGLIWTIILHFQI 150
Query: 143 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 202
++ S S D AK+ LL W Q
Sbjct: 151 SDI----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGY 179
Query: 203 TGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRL 262
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RL
Sbjct: 180 QGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRL 239
Query: 263 LDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF--- 319
LDPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 240 LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQW 298
Query: 320 ---------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYE 366
+R F+E+++ QF E +L + ++ + YQS + +
Sbjct: 299 MRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQ 358
Query: 367 MKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLY 426
+K H + GKL + L ++ R + ++ L G L
Sbjct: 359 LKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLN 417
Query: 427 RAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKR 468
+A+ L+ ++ + + + A ++R L++ ++ Q ++R
Sbjct: 418 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR 477
Query: 469 AF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRL 519
+ HE Y R G+ P Q+ V+ S ++E L+Y L
Sbjct: 478 VYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-L 529
Query: 520 LSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTY 567
LL E L S + G + Q ++ + + IE ++ E
Sbjct: 530 QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG----- 584
Query: 568 QILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------E 616
Q+ T Y G ++ K +N + A+ R+L S + + ++ E
Sbjct: 585 QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 642
Query: 617 EVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHT 665
EV +W DR N A +++ LE EK + + +NA R P
Sbjct: 643 EVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQA 702
Query: 666 AMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVV 725
A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 703 ALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ-------------- 741
Query: 726 TLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP 785
L +K S + ++ L+QD +D ++++ + K A + + P
Sbjct: 742 -LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 800
Query: 786 QEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDS 837
+ M + +++ + K EC QL+ P + ++ S S
Sbjct: 801 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGS 851
Query: 838 LGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLK 897
+ + ++ Q + ++ +T +E Q++ VTL + L
Sbjct: 852 EAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL- 890
Query: 898 HFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
H D L +A+QS+ + + R +K EE R L + Q L
Sbjct: 891 HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFL 941
Query: 958 EEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--K 1010
+ D PE+ L E+ S C L + +QG QE R +
Sbjct: 942 RDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQR 988
Query: 1011 LHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEK 1063
+ KD LQ EA H L L +D E R EC + + K + EG K
Sbjct: 989 CISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGK 1042
Query: 1064 IIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTY 1123
+ RL E + LP P T LR+ ++ T
Sbjct: 1043 GV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTL 1075
Query: 1124 RKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRA 1173
KL + Y + S + +E QLK + K +
Sbjct: 1076 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS 1135
Query: 1174 VEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKAL 1224
++++R + T L+ L+ EV + E ++ + +A+L ++A+
Sbjct: 1136 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1195
Query: 1225 VTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEA 1278
+ ++ L G ++Y + L + ++ QEQ A+ E L +
Sbjct: 1196 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1255
Query: 1279 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDR 1316
Q LL ++ +++ +R +Q I + E L +
Sbjct: 1256 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1315
Query: 1317 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
+E L + L + + I TLR+ E E E Q ER
Sbjct: 1316 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER---- 1365
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIK 1431
L + + LE+ ++ ++ QAE KE E+ + QQQ +SI+
Sbjct: 1366 --LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 1432 EQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQIS 1491
E++++L + E +I+ + E I +L A E + ++
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQ 1480
Query: 1492 QIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQ 1548
++ +E E++ +EEA+ + V + +A++ ++++ E RE +
Sbjct: 1481 ALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQA 1608
L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1538 ALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA------------- 1580
Query: 1609 LESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLA 1662
L S +F+ ++ S +E A+ Q E+ RRA+++ A E L
Sbjct: 1581 --ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Query: 1663 HWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1713
WQ RL+ E + L + EA+ E + A R G+ + Q E+
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQREL 1693
Query: 1714 VSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1773
Q + L + +A++ ++ ++ EQ +++ + L + + + + +
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 1774 HQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE------- 1819
Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813
Query: 1820 VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFE 1861
E K + Q + A KL ++G A ++ L + +AE+ E
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----E 1868
Query: 1862 EASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQ 1921
++ E L E H + I +L Q +A++S + + L+E L Q
Sbjct: 1869 RLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1926
Query: 1922 NAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERI 1969
+ + + S + KA+ L++G S EQ A QL E ER
Sbjct: 1927 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1986
Query: 1970 QNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVF 2028
+ ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++
Sbjct: 1987 RR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 2029 NQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQC 2088
+ K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2044 QE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 2089 CGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQK 2147
E + + A + ++ V + E+ A ++ + A K+ + +
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2147
Query: 2148 DLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWD 2207
++ + K+ ++ K E T L ++E+ + LR+ L D
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETD 2203
Query: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEEL 2261
+ DE + A S ++ L + EEL K + E +N+AL L +
Sbjct: 2204 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2262
Query: 2262 HSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFIN 2321
K N + L + E + A L + A + ++A+ +D Q EK +
Sbjct: 2263 --KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLK 2317
Query: 2322 DITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRK 2376
+ V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2318 E---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 2377 YHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAA 2436
+LE A ++ E S+ QA +E ++ F + +E E + A
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELAT 2428
Query: 2437 KESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ 2495
+E ++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE 2486
Query: 2496 ITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
Q L++ QALQ SE S + R + ++E+ F E + +++
Sbjct: 2487 -------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQ 2532
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQN 2614
Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------E 2576
Query: 2615 LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQI 2674
L ++ +++ + ++ +E++ L E LQ + +A LA +E S+ K L
Sbjct: 2577 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNG 2633
Query: 2675 QDIL 2678
+D L
Sbjct: 2634 RDAL 2637
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 253 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 312
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 313 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 355
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 356 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 404
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 405 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 461
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 462 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 518
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 519 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 575
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 576 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 627
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 628 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 685
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 686 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 743
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 744 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 803
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 804 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 858
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 859 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 918
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 919 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 978
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 979 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1033
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1034 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1091
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1152 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1272 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1329
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1330 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1385
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1386 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1423
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1468
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1469 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1518
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1519 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1573
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1574 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1634 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1674
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1728
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1729 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1785
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1838
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 1893
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 1894 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2054
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2055 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2112 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2169
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2170 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2229
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2290 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2346
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2401
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2402 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2447
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2448 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2488
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2489 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2582
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1140 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1186
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1187 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1238
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1239 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1297
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1413
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1529
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1709
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1710 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1761
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1762 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1819
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1820 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 1879
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 1880 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 2000 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2048
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2109 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2143
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2144 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2252
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2253 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2311
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2312 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2367
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2368 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2410
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2460
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2514
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2515 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2570
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2571 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2627
Query: 6335 ALLP 6338
LP
Sbjct: 2628 KTLP 2631
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 551 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 605
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 606 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 661
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 662 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 700
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 701 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 739
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 740 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 779
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 780 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 836
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 837 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 889
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 890 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 949
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 950 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1008
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1009 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1067
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1068 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1115
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1116 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1168
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1169 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1228
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1229 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1285
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1286 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1345
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1346 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1405
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1406 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1460
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1521 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1575
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1576 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1625
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1685
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1744 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1785
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1786 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1838
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1839 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 1899 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 1949
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 2007
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 2008 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2058
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2118
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2119 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2178
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2179 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2230
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2231 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2350 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2402
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2403 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2460
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2461 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2507 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2531
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1148
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1149 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1208
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1209 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1268
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1269 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1328
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1329 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1388 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1444
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1445 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1492
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1493 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1546
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1603
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1840
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 1895
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2076 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2235
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2236 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2265
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2266 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2325
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2326 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2432 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2492 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2526
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2586
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2587 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2637
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 982 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 1032
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1088
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1144
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1145 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1203
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1204 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1251
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1252 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1306
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1307 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1359
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1360 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1415
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1416 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1475
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1476 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1533
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1589
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1590 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1641
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1642 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1700
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1701 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1742 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1793
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1854 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 1966 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 2016
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 2017 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2054
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2055 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2111
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2151
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2152 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2206
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2207 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2255
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2256 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2305
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2306 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2352
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2353 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2410
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2411 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2464 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2574
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2575 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2630 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2677
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 396 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 452
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 453 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 505
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 506 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 562
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 563 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 617
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 618 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 675
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 676 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 732
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 733 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 792
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 793 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 852
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 853 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 910
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 911 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 966
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 967 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1022
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1023 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1076
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1191
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1311
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1371
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1372 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1431
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1432 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1491
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1492 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1551
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1552 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1611
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1671
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1672 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1721
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 1895 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 1953
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2011
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 2012 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2069
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2130 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2180
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2181 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2235
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2236 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2290
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2291 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2341 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2398 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2455
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2511
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2512 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2569
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2570 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2596
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1177 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1236
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1237 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1296
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1413
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1473
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1474 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1533
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1706
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1707 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1755
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1806
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1807 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1846
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1847 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 1893
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 1894 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 1947 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2051
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2108
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2229 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2285
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2286 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2345
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2404
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2405 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2455
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2510
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2511 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2565
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2566 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2616
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2617 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2668
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2669 S-AEELQRLAQGHTTVDELA 2687
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1146 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1198
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1199 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1258
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1259 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1318
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1365
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1420
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1421 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1480
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1601 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1655 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1708
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1709 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1817
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1818 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 1876
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 1877 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1936
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 1937 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2114 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2173
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2294 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2333
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2334 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2393
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2394 AEMSR 2398
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 983 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1030
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1031 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1088
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1089 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1147
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1148 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1189
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1190 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1245
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1246 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1298
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1299 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1358
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1359 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1418
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1538 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1592
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1593 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1650
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1711 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1821
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1822 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 1871
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 1872 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 1916
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 1917 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 1949
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2067
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2068 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2110
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2111 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2165
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2166 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2218
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2219 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2278
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2279 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2330
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2331 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2371
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2372 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2425
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2426 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2467
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2468 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2509
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2510 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2560
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2561 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2595
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2596 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2649
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2650 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2706
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2707 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2737
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1136
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1255
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1256 QALLEEIE 1263
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 959 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 1016
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 1017 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1076
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1077 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1136
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1137 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1196
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1197 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1253
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1254 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1293
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1294 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1352
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1413 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1523
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1583
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1584 SKRASFAEKTAQLERSL 1600
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 260 bits (665), Expect = 4e-68
Identities = 593/2884 (20%), Positives = 1111/2884 (38%), Gaps = 516/2884 (17%)
Query: 23 DEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRR 82
DE++ VQK+TFTKW+N HL K + + DL+ED++DG L++LLEVLSG LP E+GR
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM 232
Query: 83 MKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQI 142
R H + N+ AL +L R+ +KLVNI + DIADG P + LGL+WTIIL+FQI
Sbjct: 233 --RFHKLQNVQIALDYLRHRQ-------VKLVNIRNDDIADGNPKLTLGLIWTIILHFQI 283
Query: 143 EELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYTAGKQ 202
++ S S D AK+ LL W Q
Sbjct: 284 SDI----------QVSGQSEDM---------------------TAKEKLLLWSQRMVEGY 312
Query: 203 TGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRL 262
G+ +F SWR G F+++IH +P L+D+ V ++N ENL+ AF++AE +LG+ RL
Sbjct: 313 QGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRL 372
Query: 263 LDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNF--- 319
LDPEDVDV +PDEKSI+TYV+ P + + DG +E+ + + V
Sbjct: 373 LDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVRANELQLRWQEYRELVLLLLQW 431
Query: 320 ---------KREDRVIFKEMKVWIEQF----ERDLTRAQMVESNLQDKYQSFKHFRVQYE 366
+R F+E+++ QF E +L + ++ + YQS + +
Sbjct: 432 MRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQ 491
Query: 367 MKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLY 426
+K H + GKL + L ++ R + ++ L G L
Sbjct: 492 LKVPPGYHPLDVEKEWGKLHV-AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLN 550
Query: 427 RAEVALREEITVQQVHE--ETANTIQRKLEQHKDLL----------------QNTDAHKR 468
+A+ L+ ++ + + + A ++R L++ ++ Q ++R
Sbjct: 551 QADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR 610
Query: 469 AF--HE-------IYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRL 519
+ HE Y R G+ P Q+ V+ S ++E L+Y L
Sbjct: 611 VYRLHERLVAIRTEYNLRLKAGVAAPATQVAQ-------VTLQSVQRRPELEDSTLRY-L 662
Query: 520 LSLLVLAESK------------LKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTY 567
LL E L S + G + Q ++ + + IE ++ E
Sbjct: 663 QDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG----- 717
Query: 568 QILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNL----SVEVRSVRSML-------E 616
Q+ T Y G ++ K +N + A+ R+L S + + ++ E
Sbjct: 718 QLSPATRGAYRDCLGRLD--LQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE 775
Query: 617 EVISNW-DRYGNTVASLQAW------LEDAEKMLNQSENAKKDFFRN----LPHWIQQHT 665
EV +W DR N A +++ LE EK + + +NA R P
Sbjct: 776 EVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQA 835
Query: 666 AMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEYTDCVV 725
A+ +++++ C + LK+ N + + F +V++ A+
Sbjct: 836 ALQTQWSWMLQLCC-CIEAHLKE-----NAAYFQFFSDVRE-AEGQ-------------- 874
Query: 726 TLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESP 785
L +K S + ++ L+QD +D ++++ + K A + + P
Sbjct: 875 -LQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKP 933
Query: 786 QEEGKEMFATM--------SKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDS 837
+ M + +++ + K EC QL+ P + ++ S S
Sbjct: 934 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC---------QLVGPAQPSHWKVLSSSGS 984
Query: 838 LGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLK 897
+ + ++ Q + ++ +T +E Q++ VTL + L
Sbjct: 985 EAAVPSVCFLVPPPNQEA-----------------QEAVTRLEAQHQAL---VTLWHQL- 1023
Query: 898 HFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGL 957
H D L +A+QS+ + + R +K EE R L + Q L
Sbjct: 1024 HVDMKSL--------LAWQSLRRDVQLIRSWSLATFRTLKP-EEQRQALHSLELHYQAFL 1074
Query: 958 EEKGD-----PEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVR--K 1010
+ D PE+ L E+ S C L + +QG QE R +
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGS-------------CSHHYQQLLQSLEQGAQEESRCQR 1121
Query: 1011 LHKQWKD--LQGEA----PYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQ-EGSEK 1063
+ KD LQ EA H L L +D E R EC + + K + EG K
Sbjct: 1122 CISELKDIRLQLEACETRTVHRLRLPLDKEPAR------ECAQRIAEQQKAQAEVEGLGK 1175
Query: 1064 IIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTY 1123
+ RL E + LP P T LR+ ++ T
Sbjct: 1176 GV-----------------ARLSAEAEKVLALPEPSPAAPT----------LRSELELTL 1208
Query: 1124 RKLMEDPDKWKDYTSRFSEFS----------SWISTNETQLKGIKGEAIDTANHGEVKRA 1173
KL + Y + S + +E QLK + K +
Sbjct: 1209 GKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS 1268
Query: 1174 VEEIRNGVTKRGETLSWLKSRLKVLTEVSS---------ENEAQKQGDELAKLSSSFKAL 1224
++++R + T L+ L+ EV + E ++ + +A+L ++A+
Sbjct: 1269 LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAV 1328
Query: 1225 VTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSKEVQEQ------AEKILDTENLFEA 1278
+ ++ L G ++Y + L + ++ QEQ A+ E L +
Sbjct: 1329 LAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE 1388
Query: 1279 QQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGL----------------------PDR 1316
Q LL ++ +++ +R +Q I + E L +
Sbjct: 1389 QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSES 1448
Query: 1317 GHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
+E L + L + + I TLR+ E E E Q ER
Sbjct: 1449 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ------QRAEERER---- 1498
Query: 1377 SSLESLSSELEQTKEFSKRTESIAVQAENLVKE-----ASEIPLGPQNKQLLQQQAKSIK 1431
L + + LE+ ++ ++ QAE KE E+ + QQQ +SI+
Sbjct: 1499 --LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 1432 EQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQIS 1491
E++++L + E +I+ + E I +L A E + ++
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEE---EIRVVRLQLEATERQRGGAEGELQ 1613
Query: 1492 QIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAKL---TQIRRYGEELREHAQ 1548
++ +E E++ +EEA+ + V + +A++ ++++ E RE +
Sbjct: 1614 ALRARAEEAEAQKRQ---AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 1549 CLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQA 1608
L+ L L Q EE R+++Q+ E ++ V ++ + E
Sbjct: 1671 ALQA--LEELRLQA--EEAERRLRQAEVERARQVQVALETAQRSAEA------------- 1713
Query: 1609 LESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTA------LENLLA 1662
L S +F+ ++ S +E A+ Q E+ RRA+++ A E L
Sbjct: 1714 --ELQSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Query: 1663 HWQ---------RLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEV 1713
WQ RL+ E + L + EA+ E + A R G+ + Q E+
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR---RGKAEEQAVRQREL 1826
Query: 1714 VSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAE 1773
Q + L + +A++ ++ ++ EQ +++ + L + + + + +
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886
Query: 1774 HQQFDELLLSFSVWIKLFLS-------ELQTTSEISIMDHQVALTRHKDHAAE------- 1819
Q+ + L +++ L+ E ++TSE S + R ++ A E
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946
Query: 1820 VESKKGELQSLQGHLA------------KLGSLGRA------EDLHLLQGKAEDCFQLFE 1861
E K + Q + A KL ++G A ++ L + +AE+ E
Sbjct: 1947 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN-----E 2001
Query: 1862 EASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQ 1921
++ E L E H + I +L Q +A++S + + L+E L Q
Sbjct: 2002 RLRRLAEDEAFQRRRLEEQAAQHK--ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059
Query: 1922 NAKALESAAVSLD-GILSKAQYHLKIG-----------SSEQRTSCRATADQLCGEVERI 1969
+ + + S + KA+ L++G S EQ A QL E ER
Sbjct: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119
Query: 1970 QNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIEERTDK-ERLKEPTRQALQQRLRVF 2028
+ ++ +LA ++A + Q++ L+ +E ++ + ++ RL+E Q ++L++
Sbjct: 2120 RR--EAEERVQKSLAAEEEAAR-QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 2029 NQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQC 2088
+ K Q +K AFA V ++ L+ T + ++ + +G+
Sbjct: 2177 QE--------------AAQKRLQAEEKAHAFA--VQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 2089 CGLIDLMREYQNLK-SAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQK 2147
E + + A + ++ V + E+ A ++ + A K+ + +
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280
Query: 2148 DLDNFTSKGKHLLSELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWD 2207
++ + K+ ++ K E T L ++E+ + LR+ L D
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQT----LRQKAQVEQELTTLRLQLEETD 2336
Query: 2208 DVLSTRDEIEGWSNNCVPQMAENISNLDNHL-----RAEELLK-EFESEVKNKALRLEEL 2261
+ DE + A S ++ L + EEL K + E +N+AL L +
Sbjct: 2337 HQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD- 2395
Query: 2262 HSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFIN 2321
K N + L + E + A L + A + ++A+ +D Q EK +
Sbjct: 2396 --KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE---EDLAQQRALAEKMLK 2450
Query: 2322 DITTWFTKVEESLMNCAQNETCE-----ALKKVKDIQKELQSQQSNISSTQENLNSLCRK 2376
+ V+E+ A+ E + A ++ + +Q++ + ++ +
Sbjct: 2451 E---KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 2377 YHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAA 2436
+LE A ++ E S+ QA +E ++ F + +E E + A
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDAQR-FRKQAEEIGEKLHRTELAT 2561
Query: 2437 KESSDRTGDSKVLEAKL-HDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQ 2495
+E ++ + HD + + +++++ + + + + QE + L L + + ++Q++
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL--QLKSEEMQTVQQE 2619
Query: 2496 ITKANEEFQAFLKQCLKDKQALQDC-ASELGSFEDQHRKLNLWIHEMEERFNTENLGESK 2554
Q L++ QALQ SE S + R + ++E+ F E + +++
Sbjct: 2620 -------------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE-VAKAQ 2665
Query: 2555 QHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQN 2614
Q E++ + ++E L+A+ E ++R Q +EEG QE
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASMEE----ARRRQHEAEEGVRRKQE------------E 2709
Query: 2615 LLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQI 2674
L ++ +++ + ++ +E++ L E LQ + +A LA +E S+ K L
Sbjct: 2710 LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEEVTASQVAATKTLPNG 2766
Query: 2675 QDIL 2678
+D L
Sbjct: 2767 RDAL 2770
Score = 125 bits (313), Expect = 2e-27
Identities = 525/2555 (20%), Positives = 984/2555 (38%), Gaps = 413/2555 (16%)
Query: 4646 RAILDEVAGLGEAVDELNQKKEGFRSTGQP--WQPDKMLHLVTLY---HRLKRQTEQRVS 4700
++I+ V+ L +A+ + ++G R+ WQ + L L+ L H E+R
Sbjct: 386 KSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFP 445
Query: 4701 LLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLK-----MYHSLAGSLQ 4755
S+++E E + Q K E LPA+E K +Y SL G++Q
Sbjct: 446 ------SSFEEIEILWSQF-----------LKFKEMELPAKEADKNRSKGIYQSLEGAVQ 488
Query: 4756 DSGIVLKRVTIHLEDLAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQS 4815
+ + P PL EK ++ E + + E + EC R+V
Sbjct: 489 AGQL----------KVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERL-ECLQRIVTK 537
Query: 4816 IDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIM-NALS 4874
+ Q E + L + A L V L L + + +++ ++ S +R++ N +
Sbjct: 538 L--QMEAGLCEEQLNQADALLQSDVRL-LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594
Query: 4875 ------HKEKEKFTKA-----KELISADLEHSLAELSELDGDIQEALRTRQATLT----- 4918
H + E+ + + L++ E++L + G A + Q TL
Sbjct: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA---GVAAPATQVAQVTLQSVQRR 651
Query: 4919 -EIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSN 4977
E+ RY Q A W+E+ Q + A G+D+ S E L SH + ++F +
Sbjct: 652 PELEDSTLRYLQDLLA---WVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAK 708
Query: 4978 LEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQK 5037
+E S L P + ++ L L+L+ ++ S A++ R H +
Sbjct: 709 IERARSDEGQLSPATRGAYRDCL----GRLDLQYAKLLNSSKARL----RSLESLHSFVA 760
Query: 5038 AREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQ 5097
A + + +N+ E++ F +++ A K + AL+ + +KI L+ +
Sbjct: 761 AATKELMWLNEKEEEEVGFDWSDRNTNMTA--KKESYSALMRELELKEKKIKELQNAGDR 818
Query: 5098 LEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMID 5157
L + + A + T+ + +W+ + + E L++ + F++ V++A +
Sbjct: 819 LLREDHPA-RPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSD-VREAEGQLQ 876
Query: 5158 QLQDKL--PGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQ----DG 5211
+LQ+ L S A+ L LL+ +L + + L L ++ +++Q
Sbjct: 877 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP 936
Query: 5212 AAPTPGEEPPL------MQEITAMQ-DRCLNMQEKVKTNGKLVKQELKDREMVETQINSV 5264
A P G P L E+T + D C + ++ K++ E + SV
Sbjct: 937 AHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-----EAAVPSV 991
Query: 5265 KCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYL-------GL 5317
V + ++AQ + L L + +++ +++ L
Sbjct: 992 CFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATF 1051
Query: 5318 YTILPSE--LSLQLAEVALDLKIRD------------------------QIQDKIKEVEQ 5351
T+ P E +L E+ +RD Q ++ +EQ
Sbjct: 1052 RTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQ 1111
Query: 5352 SKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAA 5411
R I +L KD+ L + +T + ++ D++ E C ++ E A
Sbjct: 1112 GAQEESRCQRCISEL-KDIRLQLEACETRTVHRLRLPLDKEPARE----CAQRIAEQQKA 1166
Query: 5412 VQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKW 5471
Q +E G+ L+ + K+ L + + A S+L LE+ + + L+
Sbjct: 1167 -QAEVEGLGKGVARLSAEAEKVLALPEPS-PAAPTLRSELELTLGKLEQVRSLSAIYLEK 1224
Query: 5472 IEKAKVLAHGT-----IAWNSASQLREQYILHQTL--LEESKEIDSELEAMTEKLQYLTS 5524
++ ++ GT + QL+E + TL LE +K +L A E Q
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284
Query: 5525 VY---------CTEKMSQQVAELGRETEELRQMI--------------KIRLQNLQDAAK 5561
E++ Q+ E E E R+ + +R + L+ +
Sbjct: 1285 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344
Query: 5562 DMKKFEAELKKLQAALEQA----QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQA 5617
++ + L A L+ A + P +++EQL Q LL E+E KV+
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404
Query: 5618 VQ-LCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQC--NIMQAAVVQYEQYEQ 5674
Q + + +D L L +L+ AS + +Q +++Q V Y +
Sbjct: 1405 CQRFAKQYINAIKDY--ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE 1462
Query: 5675 ----EMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSK 5730
++++ + E R E++ +A E + +++ E +K Q Q+A +++
Sbjct: 1463 LTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK----QRQLAEAHAQ 1518
Query: 5731 CKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVT 5790
K + EV E D + +
Sbjct: 1519 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ----------------------KRSIQ 1556
Query: 5791 EESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS 5850
EE + +SE R + + ++I RLQ +A
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI------RVVRLQLEAT--------- 1601
Query: 5851 QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEA 5910
E G E G+LQ + ++K++ EA +++ QD +S +
Sbjct: 1602 -ERQRGGAE-------GELQALRARAEEAEAQKRQAQEEAERLRRQVQD--ESQRKRQAE 1651
Query: 5911 IELKLSESPEPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQL 5970
+EL E + E Q A QAL E L LQ E E + L + V + + A +
Sbjct: 1652 VELASRVKAEAEAAREKQRA-LQAL--EELRLQAE--EAERRLRQAEVERARQVQVALET 1706
Query: 5971 ALQSTLTVL-AERMSTIRMKASGKRQLLEE-----KLNDQLEEQRQEQA-LQRYRCEAD- 6022
A +S L ++R S A +R L EE +L ++ E + Q+QA +R R EA+
Sbjct: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766
Query: 6023 ELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLE 6082
EL+ W L L L + +QK +A +E E E
Sbjct: 1767 ELERWQLKANEALRLRLQAEE-----------------VAQQKSLAQAEAEKQKEE--AE 1807
Query: 6083 GKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTAQEK---EESDVDLTATQSP 6139
+A + +AE+ A + R L LE QR L +GTAQ++ E+ + L A
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQL------AEGTAQQRLAAEQELIRLRAETEQ 1861
Query: 6140 GVQ--EWLAQARTTWTQQRQSSLQQQKELEQEL----AEQKSLLRSVASRGEEILIQHSA 6193
G Q + L + ++ ++ Q+++ELE EL AE + LL S A EE S
Sbjct: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRST 1918
Query: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
+E S E +EL E + A + + L +E + +Q+ E E+V
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR-------AEAERV 1971
Query: 6254 LYSRPNRLLSGVPL-YKGDVPTQDKSAVTSLLDGL--NQAFEEVSSQSGGAKRQSIHLEQ 6310
L + + L + ++ ++K A L L ++AF+ + A+ ++
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA----- 2026
Query: 6311 KLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDI----KEMSEEMDKNK 6366
D+EERL A L + +++ L Q+ L +D +++ EE+ K
Sbjct: 2027 --------------DIEERL----AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068
Query: 6367 NLFSQAFP-------ENGDNRDVIEDTLGCL------LGRLSLLDSVVNQRCHQMKERLQ 6413
F +A E G R EDTL R L + +R + +ER+Q
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128
Query: 6414 QILNFQNDL----KVLFTSLADNKYII--LQKLANVFEQPVAEQIEAIQQAEDGLKEFDA 6467
+ L + + K + K + ++L EQ A Q++ Q+A + +
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE- 2187
Query: 6468 GIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYER-ALQD 6526
E Q EQ Q L + Q + D+L + R + + Q ER A Q
Sbjct: 2188 ---EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244
Query: 6527 LADLLETGQEKMAGDQKIIVSSKEEIQQLLDK-HKEYFQGLESHMILTETLFR--KIISF 6583
+ E + K + +++ ++ + Q +K KE Q + R +
Sbjct: 2245 RRQVEEAERLKQSAEEQ--AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADA 2302
Query: 6584 AVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQ-------ELSRQLEV 6636
++K +F + + Q + V + ++LE + LDE+ Q E +RQ
Sbjct: 2303 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQ 2362
Query: 6637 VESSIPSVGLVEENEDRLIDRITL---------YQHLKSSLNEYQPKLYQVLDDGKRLLI 6687
VE + SV + E +L RI + + L E K+ QV ++ RL +
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422
Query: 6688 SISCSDLESQLNQLGECWLSNTNKMS-KELHRLETILKHWTRYQSESADLIHWLQSAKDR 6746
+ + ++L QL E L+ ++ K L ++ TR ++E+ L + A+++
Sbjct: 2423 A---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479
Query: 6747 LEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATL 6806
+ + Q+L LE ++ + S ++ L LR+ ++ A
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK-----LRVAEMSRAQA 2534
Query: 6807 RSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISLMENVIQKDEDNI 6866
R+E D+Q + EKLH+ ++ A E ++ + +E IQ+ + +
Sbjct: 2535 RAE---EDAQ--RFRKQAEEIGEKLHRTEL-------ATQEKVTLVQTLE--IQRQQSDH 2580
Query: 6867 KNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLG 6926
+AI E L++ K K+ K +LQ+ S+++++ + EQL
Sbjct: 2581 DAERLREAIAE-LEREKE-KLQQEAK----------LLQLKSEEMQTVQQ------EQL- 2621
Query: 6927 AMNKSWQILQGLVTEKIQLL--EGLLESWSE-----YENNVQCLKTWFETQEKRLKQ--Q 6977
+ ++ + Q ++EK LL E +E +++ V + E Q+++ +Q Q
Sbjct: 2622 -LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 6978 HRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQ 7012
R AS++ A + + E+ ++ K++E++++EQ
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715
Score = 119 bits (298), Expect = 1e-25
Identities = 326/1624 (20%), Positives = 617/1624 (37%), Gaps = 248/1624 (15%)
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKE-KFTKAKELIS 4889
R +AE P + +++E+R Q E +Q H E++ + + +E ++
Sbjct: 1273 RAQAEAQQPTF-----DALRDELRGAQEVGERLQQR--------HGERDVEVERWRERVA 1319
Query: 4890 ADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDA---QELLQ 4946
LE A L++ D RQ L ++ Q + Y + WL+DA QE +Q
Sbjct: 1320 QLLERWQAVLAQTD--------VRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371
Query: 4947 LAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKP------TGKEDL 5000
A D ++ E L+ ++ +EE IK T K L
Sbjct: 1372 -AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430
Query: 5001 EQKVASLELRSQRMSRDSGAQ--VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSL 5058
E + + + +S Q VDL + + + I+ +++T +++ E
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYVDL----RTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 5059 LKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVW 5118
L E E+L+E +A + E + +A + K + + R
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAV 1546
Query: 5119 QRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKAT-------EMIDQLQDKLPGSSAEKA 5171
+ R++ ++ +++ + + E + + A E I ++ +L + ++
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 5172 -SKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQ 5230
++ EL L + + Q Q LR+Q +QD + E L + A
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQ----VQDESQRKRQAEVELASRVKAEA 1662
Query: 5231 D------RCLNMQEKVKTNGKLVKQELKDREM---------VETQINSVKCWVQETKEYL 5275
+ R L E+++ + ++ L+ E+ +ET S + +Q +
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 5276 GNPTIEIDAQLEELQILLT------EATNHRQNIEKMAEEQKEKYLGLYTILPSE---LS 5326
T +++ L+E + + E +Q + A E+ E+ L + + +E L
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 5327 LQLAEVALDLKIRDQIQDKIKE----------------VEQSKATSQELSRQIQ------ 5364
LQ EVA + +K KE V Q + QEL +Q Q
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1842
Query: 5365 --KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQL 5422
+LA + I +L+A+T+ Q + +++L EEL E AA QK E +L
Sbjct: 1843 QQRLAAEQELI--RLRAETE---QGEQQRQLLEEELARLQR---EAAAATQKRQELEAEL 1894
Query: 5423 GKPLAKK---IGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLA 5479
K A+ + +++ +E +L A E E + E+AK
Sbjct: 1895 AKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK--R 1952
Query: 5480 HGTIAWNSASQLREQY----------ILHQTLLEESKEID-SELEAMTEKLQYLTS--VY 5526
+A A++ R + I T L+ EI E EA E+L+ L +
Sbjct: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAF 2012
Query: 5527 CTEKMSQQVAELGRETEE----LRQMIKIRLQN----LQDAAKDMKKFEAELKKLQAALE 5578
++ +Q A+ + EE LR+ L+ ++D + ++ E E+ L+A+ E
Sbjct: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 5579 QAQATLTSPEV--GRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLP 5636
+A A E+ GR+ + + R +E+E+ + + A + + E V SL
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 5637 LCHAALRLQEEASRLQHTAIQQCNIMQAAVVQY----EQYEQEMKHLQQLIEGAHREIED 5692
+EEA+R + A+++ ++A V + E+ EQE QL + E
Sbjct: 2133 A-------EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ----EAAQ 2181
Query: 5693 KPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEG 5752
K + A + +EL Q ++ Q + L + + A+ A E E
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 5753 LAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPS 5812
+ + E L ++S EE + + A
Sbjct: 2242 AQSRRQVEEAERL-------------------------KQSAEEQAQARAQAQAAAEKLR 2276
Query: 5813 PVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRS 5872
A +A+ QA ++ DA A Q + L
Sbjct: 2277 KEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334
Query: 5873 WETLKNVISEKQRTLY----EALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQ 5928
+ KN++ E+ + L EA ++ + ++ L S+ +ME + KL E
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS-KLKARIE-------- 2385
Query: 5929 MAEHQALM----DEILMLQDEINELQSSLAEELVSESCEADPA--------EQLALQSTL 5976
AE++AL+ D E E +AEE S A A E LA Q L
Sbjct: 2386 -AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444
Query: 5977 TVLAERMSTIRMKA--SGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLSTKAT 6034
AE+M +M+A R E +L Q +E QEQA +R + + +++ L
Sbjct: 2445 ---AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA-RRLQEDKEQMAQQLAEETQG 2500
Query: 6035 LDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQL 6094
L EA+ M E E+ + ++E+S +A +++A++
Sbjct: 2501 FQRTL---------EAERQRQLEMSAEAERLKLRVAEMS--------RAQARAEEDAQRF 2543
Query: 6095 AGKLRRLKGSLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQ 6154
+ + L + A +K +Q ++++SD D + ++E +A+ +
Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-----AERLREAIAEL-----E 2593
Query: 6155 QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGME 6214
+ + LQQ+ +L Q +E+ ++ +E L+Q + A EK +L +E +E
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQ------QEQLLQETQALQQSFLSEKDSLLQRERFIE 2647
Query: 6215 GEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPT 6274
EK+ E Q+ + Q+ +Q+ Q +EQE+++++ S + ++ +
Sbjct: 2648 QEKAKLE-QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE---ARRRQHEAEEGV 2703
Query: 6275 QDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVAT 6334
+ K L+ + EE+ ++ R+ + L ++ + A S ++V AT
Sbjct: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS---EEVTASQVAAT 2760
Query: 6335 ALLP 6338
LP
Sbjct: 2761 KTLP 2764
Score = 119 bits (297), Expect = 2e-25
Identities = 427/2188 (19%), Positives = 827/2188 (37%), Gaps = 336/2188 (15%)
Query: 2445 DSKVLEAKLHDLQNILDSVSDGQSKLD-AVTQEGQTLYAHLSKQIVSSIQEQITKANEEF 2503
D +EA+L + + S+ + ++K++ A + EGQ LS + ++ + + + ++
Sbjct: 684 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ-----LSPATRGAYRDCLGRLDLQY 738
Query: 2504 QAFLKQCLKDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNE 2563
L ++L+ L SF K +W++E EE + + ++ KK
Sbjct: 739 AKLLNSSKARLRSLES----LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKES 794
Query: 2564 VHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLTSHQNLLRMTKEKL 2623
+ + EL + + +L G L E H A R T E
Sbjct: 795 YSAL---MRELELKEKKIKELQNAGDRLLREDHPA------------------RPTVESF 833
Query: 2624 RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGE 2683
++ ALQ+ W W+ + C E+ L + S +++ E
Sbjct: 834 QA-------------ALQTQWSWMLQL---CCCIEAHLKENAAYFQFFSDVRE-----AE 872
Query: 2684 GEVKLNMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWN 2743
G+++ K ++ALR + T+LE L + AQ E Q N
Sbjct: 873 GQLQ------KLQEALRRKYSCDRSATVTRLEDLLQ----------DAQDEKE----QLN 912
Query: 2744 DYVERKNQLEQWMESVDQ-KIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRALHRLIA 2802
+Y + L + ++V Q K HP P G + D+ Q E H +L+
Sbjct: 913 EYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV---EVTVHKGDECQLVG 969
Query: 2803 KSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDW 2862
++ + K S + A + A+E + ++E H + H+
Sbjct: 970 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA---QHQALVTLWHQ---- 1022
Query: 2863 LHSAKEELHRWSDMSGD-------SSATQKKLS--KIKELIDSREIGASRLSR----VES 2909
LH + L W + D S AT + L + ++ + S E+ R
Sbjct: 1023 LHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGG 1082
Query: 2910 LAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQV 2969
PE + H Q L++ +Q + Q C+ L E + V
Sbjct: 1083 FGPEDRLMAEREYGSCSHHYQQLLQS-LEQGAQEESRCQRCISELKDIRLQLEACETRTV 1141
Query: 2970 AQLEQALEQFSA---LLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDL 3026
+L L++ A + QQ E + + + + +++L AL + P L
Sbjct: 1142 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL-ALPEPSPAAPTL 1200
Query: 3027 KSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFRKAFRDFQQW 3086
+S+L + + S +K + + +G Q E++L R ++
Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVI----RGTQGAEEVL--------RAHEEQ 1248
Query: 3087 LVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK----GELLSTLL 3142
L A+ +P + E+ + +++ +++E Q + + + E+ L
Sbjct: 1249 LKEAQA-------VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1301
Query: 3143 TKEKAKGIQA-----KVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLS 3197
+ + ++ +V E W+ + ++ LE L Q++ + SA+P+ WL
Sbjct: 1302 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1361
Query: 3198 KTEKMVHE-SSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQAASKS 3256
+ + + L D A R + ++ Q++LEEI + ++ + A+Q A K
Sbjct: 1362 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYIN---AIKD 1418
Query: 3257 FRHRVSQLSSQYLALSNLTKE-KV-SRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYC 3314
+ ++ +Q +++ K+ KV S + ++ E+ EL + I +
Sbjct: 1419 YELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETL 1478
Query: 3315 HPTSDKSVL--------DSRTLKLEALL----------------SVKQEKEIQMKM---I 3347
++ L R ++EA L + ++ KE+Q +M +
Sbjct: 1479 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538
Query: 3348 VTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQ 3407
V R E+ + + + +IQ++LQ ++ + + A R Q E A ++ +R
Sbjct: 1539 VRREEAAVD--AQQQKRSIQEELQQLRQSSEAEIQAKAR---QAEAAERSRLRIEEEIRV 1593
Query: 3408 FSGWMDSMEANLNESERQHAELR--------DKTTMLGKAKLLNEEVLSYSSLLETIEVK 3459
+++ E +E + LR K +A+ L +V S EV+
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653
Query: 3460 GAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWL--GQ 3517
A + E + +E+ RA+Q + + E RL Q + +V L Q
Sbjct: 1654 LASR-----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708
Query: 3518 EQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAE-D 3576
+ + S A R LQE V +V RE+ QAE +
Sbjct: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHV----------AVAQLREEAERRAQQQAEAE 1758
Query: 3577 RALESLRQDWQAYQHRLSET---RTQFNNVVNKLRLMEQKFQ-QVDEWLKTAEEKKWHEE 3632
RA E ++ + +Q + +E R Q V + L + + + Q +E + A + EE
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1818
Query: 3633 VTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSL 3692
+ E+ E Q L E R+ A Q R +A Q +Q + LEEE+ L
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQQRLA--AEQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 3693 EESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSA 3752
+ ++ +T K + + ++ KV M EVLL + +S
Sbjct: 1877 QREAAA---------ATQKR-QELEAELAKVRAEM--------EVLLASKARAEEESRST 1918
Query: 3753 REKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLEKGLHLAKEFSDKCKA 3812
EK ++ + E EA R R E+ + +L+ L +++ E+ A++ ++ +
Sbjct: 1919 SEKSKQRL----EAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERV 1971
Query: 3813 LTQWIAEYQEILHVPEEPKMELYEKKAQLSKY-----------KSLQQTVLSHEPSVK-- 3859
L + +A E + E ++ L EK+A+ + + L++ H+ ++
Sbjct: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 3860 --SVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGD 3917
+R+ ++ LE Q ++D + Q + +++ ++ KA E+ A + L +
Sbjct: 2032 LAQLRKASDSELER-QKGLVEDTLRQRRQVEEEILAL-KASFEKAAAGKAEL-------E 2082
Query: 3918 TLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEHELQKHV-SRQDTLQQ 3976
+G+ + + L+ A L+ + + + +R + E +QK + + ++ +Q
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQ 2140
Query: 3977 CQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT 4036
+A L V+ + + A +++ RA QE AR + A K
Sbjct: 2141 RKAALEEVE-----RLKAKVEEARRLRE----RAEQESARQLQLAQEAAQKRLQAEEKAH 2191
Query: 4037 AKDIQQTEQTIEQKLVQAQNL-----------TQGWEEIKHLKSELWIYLQDADQQLQNM 4085
A +QQ EQ ++Q L Q Q++ + EE + + + + +Q++
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA 2251
Query: 4086 KR-RHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLN 4144
+R + S E A+ + ++K ++A+ E+ K+ E ++
Sbjct: 2252 ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFA 2311
Query: 4145 DQWL----DLCRQSNNLCLQREE-DLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAE- 4198
+Q L + ++ L LQ EE D Q+ N+++ L++ E AR ++
Sbjct: 2312 EQTLRQKAQVEQELTTLRLQLEETDHQK--------NLLDEELQRLKAEATEAARQRSQV 2363
Query: 4199 -----STAVHLEALKKLALALQ-ERKYAIEDLKDQKQKMIEHLNLDDKELVKEQT----- 4247
S V +E L KL ++ E + I KD Q+ ++ K++ +E
Sbjct: 2364 EEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423
Query: 4248 ------------SHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPN 4295
L Q+ E ++K K+Q +V L Q+ E A+EQ
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQ-AVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 4296 IAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQKA 4355
+ E +Q MAQ L + LEA++ + +A+R+ L + E Q
Sbjct: 2483 LQEDKEQ-----MAQQLAEETQGFQRTLEAERQRQLEMSAEAERL--KLRVAEMSRAQAR 2535
Query: 4356 LSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLP 4415
+ ++ +G++ A EK L+ + Q H+ + RE I L
Sbjct: 2536 AEEDAQRFRKQAEEIGEKLHRTELATQEKVT-LVQTLEIQRQQSDHDAE-RLREAIAELE 2593
Query: 4416 DDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSV 4475
+ K Q E L + E+ EQ E Q S DS+
Sbjct: 2594 REKEK--------------LQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639
Query: 4476 LQKCSHRLQELEKNLVSRKHFKEDFDKA 4503
LQ+ R E EK + + F+++ KA
Sbjct: 2640 LQR--ERFIEQEKAKLEQL-FQDEVAKA 2664
Score = 111 bits (277), Expect = 4e-23
Identities = 320/1671 (19%), Positives = 627/1671 (37%), Gaps = 282/1671 (16%)
Query: 5286 LEELQI--LLTEATNHRQNIEKMAEEQKEKYLGLYTILP----SELSLQLAEVALDLK-- 5337
LE+L+ L+ T + + + EEQ ++ + LP ++ SL+ + +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281
Query: 5338 ----IRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKV 5393
+RD+++ + E+ + E ++++ + + +L + +A + + +
Sbjct: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341
Query: 5394 LGEELDGCNSKLMELDAAVQKFLEQNGQL-GKPLAKKIGKLTELHQQTI----------- 5441
LG +L L A +Q + Q+ PLA +L Q+
Sbjct: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401
Query: 5442 -----RQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYI 5496
R A+ ++ + L Y LE + +K KV + LR Y
Sbjct: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS 1461
Query: 5497 LHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNL 5556
TL + + SE E+ + L E+ +++AE+ E+ RQ+ + Q
Sbjct: 1462 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER-ERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 5557 QDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSH-RQHLLSEMESLKPKV 5615
A ++ K+ + +++Q + + + + + S++E+L RQ +E+++ +
Sbjct: 1521 AQAEREAKELQ---QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA 1577
Query: 5616 QAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQE 5675
+A + +S LRI E++ +RLQ EA+ Q + +QA + E+ E +
Sbjct: 1578 EAAE--RSRLRIEEEI--------RVVRLQLEATERQRGGAE--GELQALRARAEEAEAQ 1625
Query: 5676 MKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLT 5735
+ Q+ E R+++D+ + ++ QA++ + + + +E+ +L + + L
Sbjct: 1626 KRQAQEEAERLRRQVQDE-----SQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELR 1679
Query: 5736 MKAKHATMLLTVTEVE-------------------------GLAEGTEDLDGELLPTPSA 5770
++A+ A L EVE AE T L+ L
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL---QEE 1736
Query: 5771 HPSVVMMTAGRCHTLLSPVTEESGEEGTNSEI-------SSPPACRSPSPVANTDASVNQ 5823
H +V + E E E+ + R + S+ Q
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796
Query: 5824 DIAYYQALSAERLQTDAAKIHPSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVI--- 5880
A Q AER K +E E LE G Q+ + +I
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856
Query: 5881 -----SEKQRTLYE------------ALERQQKYQDSLQSISTKMEAIELKLSESPEPGR 5923
E+QR L E A +++Q+ + L + +ME + + + E R
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 5924 SPESQMAEH-QALMDEILMLQDEINELQSSLAEELVSES--CEADPAEQLALQSTLTVLA 5980
S + + +A L +E L++ LAEE + E D A Q A VLA
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRA--EAERVLA 1973
Query: 5981 ERMSTI----RMKASGKRQLLEEKL-NDQLEEQRQEQALQRYRCEADELDSWLLSTKATL 6035
E+++ I R+K + L E++ N++L +++A QR R E KA +
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH-----KADI 2028
Query: 6036 DTALSPPKEPMDMEAQ-----LMDCQNMLVEIEQKVVALS-------------ELSVHNE 6077
+ L+ ++ D E + + D ++E++++AL EL +
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Query: 6078 NLLLEGKAHTKDEAEQLAGKLRRL-----------------------------KGSLLEL 6108
E +K++AE A + R+L K +L E+
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQSPGVQEWLAQ--ARTTWTQQRQSSLQQQKEL 6166
+R + + + ++ES L Q + A+ A QQ++ LQQ +
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208
Query: 6167 EQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGMEGE--KSSAEDQM 6224
EQ + +Q A R E AE + E+ S+ E E K SAE+Q
Sbjct: 2209 EQSVLDQLRGEAEAARRAAE------EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 6225 RMKWESLHQEFSTKQKLLQNVLEQEQ-EQVLYSRPNRLLSGVPLYK--GDVPTQDKSAVT 6281
+ + ++ +++ Q + Q EQ + + + +K + + K+ V
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 6282 SLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEET 6341
L L EE Q + L+ + + S VEE LF
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS----QVEEELF---------- 2368
Query: 6342 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVV 6401
++ EE+ K K +NR +I L D
Sbjct: 2369 ------------SVRVQMEELSKLKARI------EAENRALI------------LRDKDN 2398
Query: 6402 NQRCHQMK-ERLQQILNFQNDLKVLFTSLADNKYIILQKLAN---VFEQPVAEQIEAIQQ 6457
QR Q + E+++Q+ L V A + + + LA + E+ + E+++A+Q+
Sbjct: 2399 TQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE 2458
Query: 6458 AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELS-KLQDMYDELMMIIGSRRSGLNQNLTL 6516
A LK + LQ ++ QE + +LQ+ +++ + G + L
Sbjct: 2459 A-----------TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 6517 KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL 6576
+ Q + + A+ L+ +M+ Q ++E+ Q+ + +E + L + T+
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564
Query: 6577 FRKIISFAVQKETQFH-TELMAQASAVLKRAHKRGVELEYILETWSHLDE--DQQELSRQ 6633
+ + +Q++ H E + +A A L+R ++ + +L+ S + Q++L ++
Sbjct: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 6634 LEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSD 6693
+ ++ S S +D L+ R + K+ L + L+Q D
Sbjct: 2625 TQALQQSFLS------EKDSLLQRERFIEQEKAKLEQ----LFQ---------------D 2659
Query: 6694 LESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRL------ 6747
++ QL E +M +E RL ++ R Q E+ + + Q +L
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719
Query: 6748 --EFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLL 6796
E +++ + ++L+++ + A L S+EV A + L G L
Sbjct: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770
Score = 108 bits (270), Expect = 2e-22
Identities = 374/1918 (19%), Positives = 725/1918 (37%), Gaps = 310/1918 (16%)
Query: 3764 EEGEAERLRKEIHDHMEQLKEL-TSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQE 3822
EE +R E+ D QL+ T TV + + L+K + + Q IAE Q+
Sbjct: 1115 EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK---------EPARECAQRIAEQQK 1165
Query: 3823 ILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDKID 3882
E + A+ K +L + P+ ++R + E L ++ V I
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEP----SPAAPTLRSELELTLGKLEQVRSLSAIY 1221
Query: 3883 QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQA------KLKQNVH 3936
+ L G EE+ R + Q+K + L+A KL+
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVL----RAHEEQLKEAQAVPATLPELEATKASLKKLRAQAE 1277
Query: 3937 AHLQGTKDSYSAICSTAQRMYQSL-----EHELQKHVSRQDTLQQCQAWLSAV-QPDLEP 3990
A Q T D+ AQ + + L E +++ R+ Q + W + + Q D+
Sbjct: 1278 AQ-QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1336
Query: 3991 SPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK 4050
L R Q++++R + +L D + A + + Q + ++
Sbjct: 1337 RELEQLGR-----QLRYYRESADPLGAWLQ------DARRRQEQIQAMPLADS-QAVREQ 1384
Query: 4051 LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKK 4110
L Q Q L EEI+ ++ + A Q + +K EL+L + + V KK
Sbjct: 1385 LRQEQALL---EEIERHGEKVEECQRFAKQYINAIK--DYELQLVTYKAQLEPVASPAKK 1439
Query: 4111 LQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDL--QRT 4168
+ + S + I E V+ T + E+ L Q++ ++ ++ EE L Q+
Sbjct: 1440 PKVQSGSESVIQEYVDLRT------HYSELTTLTSQYIKFISETLRR-MEEEERLAEQQR 1492
Query: 4169 RDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQE----RKYAIEDL 4224
+ + + VE LEK LA + A++ A K+L +QE R+ A D
Sbjct: 1493 AEERERLAEVEAALEKQR----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1548
Query: 4225 KDQKQKMIEHLNLDDKELVKE------QTSHLEQRWFQLEDLIKR-KIQVSVTNLE---- 4273
+ QK+ + E L + E Q E+ ++E+ I+ ++Q+ T +
Sbjct: 1549 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGA 1608
Query: 4274 --ELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSELEA------ 4325
EL +++R +E E + Q AE L++ D +Q + + S ++A
Sbjct: 1609 EGELQALRARAEEA-EAQKRQAQEEAERLRRQVQ-DESQRKRQAEVELASRVKAEAEAAR 1666
Query: 4326 -KQMLLKSL------IKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLN 4378
KQ L++L ++A+R + + + +Q AL AQ ++L +R +
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAE--AELQSKRASF-- 1722
Query: 4379 KALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQ-- 4436
+EKT L Q ++H RE ++ + + A+ L+ +Q
Sbjct: 1723 ---AEKTAQLERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLK 1774
Query: 4437 -NEVTGLWAQGRELMKEVT------EQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4489
NE L Q E+ ++ + E++K E + + + +++ QELEK
Sbjct: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK- 1833
Query: 4490 LVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLL 4549
Q + + EL A+ + +Q E L
Sbjct: 1834 -------------------QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874
Query: 4550 TLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLI 4609
LQR E L +L + + V++A K +E+ ++ +
Sbjct: 1875 RLQREAAAATQKRQE-----LEAELAKVRAEMEVLLA---SKARAEEESRSTSEKSKQRL 1926
Query: 4610 ELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCR-------AILDEVAGLGEAVDEL 4662
E EL + R+ + + + L+ +D R + +++A +GEA
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986
Query: 4663 NQKKEGFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQ 4722
+ + + +K L + + QR L E + E+ QL +
Sbjct: 1987 TEAEIALK--------EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 4723 LKSVKEEQSKVNEETLPAEEKLK--------MYHSLAGSLQDSGIVLKRVTIHLEDLAPH 4774
S E Q + E+TL +++ + A + + L R+ + ED
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 4775 LDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSR----SLDWLR 4830
+ E AR + + + E + E E R+ +S+ + E +R +L+ +
Sbjct: 2099 KEQAELEAARQRQLAAEEERRR---------REAEERVQKSLAAEEEAARQRKAALEEVE 2149
Query: 4831 RVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISA 4890
R+KA++ L + QE R++Q+ QE Q K L +
Sbjct: 2150 RLKAKVEEARRLRERAE--QESARQLQLAQEAAQ--------------------KRLQAE 2187
Query: 4891 DLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN 4950
+ H+ A + + + ++Q+ L+ Q+ L ++ + + + + A + A+ + A +
Sbjct: 2188 EKAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER--EAAQS 2244
Query: 4951 GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELR 5010
VE AE +S E Q + E+L +++ EQ+ A
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKL---------------RKEAEQEAA----- 2284
Query: 5011 SQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEK 5070
R ++ A + Q A+ ++K E+ + E++L+ L + H+
Sbjct: 2285 --RRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQK--- 2339
Query: 5071 LSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD 5130
N E++ L+ +A++ + + + S + + R A++
Sbjct: 2340 -----------NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAEN 2388
Query: 5131 QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLEL 5190
+ IL D D F +++ E + Q+ ++ S A L L E +L
Sbjct: 2389 RALILRDK-DNTQRF---LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE------DL 2438
Query: 5191 EQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQE 5250
QQ++ + ++ + +Q+ A E L Q+ Q++ +QE
Sbjct: 2439 AQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQE------------ 2485
Query: 5251 LKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-------ATNHRQNI 5303
D+E + Q+ Q T E +E+ A+ E L++ + E A Q
Sbjct: 2486 --DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543
Query: 5304 EKMAEEQKEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQI 5363
K AEE EK + +EL+ Q +V L + Q Q + E+ + EL R+
Sbjct: 2544 RKQAEEIGEK------LHRTELATQ-EKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596
Query: 5364 QKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQ--KFLEQ-NG 5420
+KL ++ L +LK++ VQ +++L E S L E D+ +Q +F+EQ
Sbjct: 2597 EKLQQEAK--LLQLKSEEMQTVQ---QEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 5421 QLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAH 5480
+L + ++ K +L ++ RQ + + + + +EE + + + +
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ---- 2707
Query: 5481 GTIAWNSASQLREQYILHQTLL-EESKEIDSELEAMTEK----LQYLTSVYCTEKMSQQV 5535
QL +Q + LL EE++ + +L+ + E+ L + V ++ + +
Sbjct: 2708 -----EELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 5536 AELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLS 5593
GR+ L A+ F+ +K+ A Q L++ E+ RL+
Sbjct: 2763 LPNGRDA----------LDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLA 2810
Score = 94.4 bits (233), Expect = 5e-18
Identities = 418/2313 (18%), Positives = 861/2313 (37%), Gaps = 321/2313 (13%)
Query: 2190 EKLEENMDRLRVSLSIWDDVLSTRD-----EIEGWSNNCVPQMAENIS-NLDNHLRAEEL 2243
E L+ + +L++ + ++ L+ D ++ + VPQ A + +LD +A+ +
Sbjct: 529 ECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLD---KADSM 585
Query: 2244 LKEFESEVKN----KALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEIT 2299
++ ++V+ + + E+++ +V L E + T E +L K A T
Sbjct: 586 IRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRT-------EYNLRLKAGVAAPAT 638
Query: 2300 EVAKGTLKDFTAQSTQVE---KFINDITTWFTKVEESLMNCAQNETCEALKKV------- 2349
+VA+ TL+ + + +++ D+ W VEE+ E L V
Sbjct: 639 QVAQVTLQSVQRRPELEDSTLRYLQDLLAW---VEENQHRVDGAEWGVDLPSVEAQLGSH 695
Query: 2350 KDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQAS 2409
+ + + ++ ++ I + + L A + LGR K + SK +
Sbjct: 696 RGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS-----SKARLR 750
Query: 2410 LQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSK 2469
ESL + + +E +L K + D + + + AK ++ + + K
Sbjct: 751 SLESLHSFVAAATKELM--WLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKK 808
Query: 2470 LDAVTQEGQTLYA--HLSKQIVSSIQEQITKANEEFQAFLKQC------LKDKQALQDCA 2521
+ + G L H ++ V S Q + ++ L+ C LK+ A
Sbjct: 809 IKELQNAGDRLLREDHPARPTVESFQAAL---QTQWSWMLQLCCCIEAHLKENAAYFQFF 865
Query: 2522 SELGSFEDQHRKLNLWI---HEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAAR 2578
S++ E Q +KL + + + L + Q ++K ++++ + L L
Sbjct: 866 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925
Query: 2579 ESLDKLSQRGQLLSEEGH----------------GAGQEGRLCSQLLTSHQNLLRMTKEK 2622
+++ +L R G G E +L SH +L + +
Sbjct: 926 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985
Query: 2623 L-------------RSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEK 2669
+ Q A+ EA +AL ++W + L +S +D
Sbjct: 986 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL--RRDVQLI 1043
Query: 2670 RLSQIQDILLMKGEGEVKLNMAIGKGEQA-LRSSNKEGQRVIQTQLETLKEVWADIMSSS 2728
R + +K E + + ++ QA LR S G + +L +E S S
Sbjct: 1044 RSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYG----SCS 1099
Query: 2729 VHAQSTLESV-------------ISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKE 2775
H Q L+S+ IS+ D + QLE ++ PL +P +E
Sbjct: 1100 HHYQQLLQSLEQGAQEESRCQRCISELKDI---RLQLEACETRTVHRLRLPLDKEPA-RE 1155
Query: 2776 KFVLLDHLQSILSEAEDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVA 2835
+ Q +E E + + RL A++ ++ E T + EL+ +T+
Sbjct: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE------LTLG 1209
Query: 2836 K-EKMRKVEEIVKDHLMYLDAVHEFT----DWLHSAKEELHRWSDMSG---DSSATQKKL 2887
K E++R + I + L + V T + L + +E+L + + AT+ L
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269
Query: 2888 SKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQ-------- 2939
K++ ++++ L A EV + + H E W++
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERL-----QQRHGERDVEVERWRERVAQLLER 1324
Query: 2940 WEDSVFQT---QSCLENLVSQMALSEQEFSGQVAQLEQA-----------LEQFSALLKT 2985
W+ + QT Q LE L Q+ + A L+ A L A+ +
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384
Query: 2986 WAQQLTLLEG-KNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSR------ 3038
Q+ LLE + E++ EC ++ ++A++ E + K+QL + ++
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444
Query: 3039 ----------DLSTYSGKVSGLIKEYNCLCLQASKGCQNKEQILQQRFR---------KA 3079
DL T+ +++ L +Y + + + +E++ +Q+ +A
Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1504
Query: 3080 FRDFQQWLVNAKI-----TTAKCFDIPQNISE--------------VSTSLQKIQEFLSE 3120
+ Q+ L A + ++ Q + E S+Q+ + L +
Sbjct: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1564
Query: 3121 SENGQHKLNMMLSKGELLSTLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKI 3180
S + + ++ S L +E+ + ++ ++ A + L + E +
Sbjct: 1565 SSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA 1624
Query: 3181 QMKDFEVSAE----PIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQ 3236
Q + + AE +QD + + E ++R+ RE+Q+ LEE+ +
Sbjct: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEE 1684
Query: 3237 LNR---------------LKEKAQQLWEGQAASK--SFRHRVSQ----LSSQYLALSNLT 3275
R E AQ+ E + SK SF + +Q L +++A++ L
Sbjct: 1685 AERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLR 1744
Query: 3276 KEKVSRLDRIVAEHNQFSLGIKELQDWM---TDAIHMLDSYCHPTSDKSVLDSRTLK--- 3329
+E R + +EL+ W +A+ + KS+ + K
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKE 1804
Query: 3330 ---LEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIR 3386
EA K E++ + + E Q EG T QQ+L + +++ IR
Sbjct: 1805 EAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG--TAQQRLAAEQEL--------IR 1854
Query: 3387 CKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTML--GKAKLLNE 3444
+++ E + ++ + + + E E + A++R + +L KA+ E
Sbjct: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914
Query: 3445 EVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAK-EAVTKSEKLVRLHQE 3503
+ + +E + EL + R RA+ E AK + E R E
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFR-------ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 3504 YQRDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQE--------LQVHCAEGQAL 3555
+R L +G+ + + + LR L E L+ A+ +A
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027
Query: 3556 LNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQ 3615
+ L S + + + ++LRQ Q + L+ + F +E +
Sbjct: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA-LKASFEKAAAGKAELELELG 2086
Query: 3616 QVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALL 3675
++ + K E+ A R ++ A + E+ + A + +R +
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQ--RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144
Query: 3676 LQVLEQIKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTL 3735
L+ +E++K EE + L E S+ + A +K + +K + L
Sbjct: 2145 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE--EKAHAFAVQQKEQEL 2202
Query: 3736 EVLLKDMEKGHSLLKSAREKGERAVKYLEEG--EAERLRKEIHDHMEQLKELTSTVRKEH 3793
+ L+ + L+ E RA + EE +AER + +E+ + L + ++
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKK---AQLSKYKSLQQT 3850
+ A++ + + QE + + L +K+ A++ K+K +
Sbjct: 2263 QARAQAQAAAEKLRKEAE---------QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQ 2313
Query: 3851 VLSHEPSVKSVREKGEALLELVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLN 3910
L + V+ +E L+L + K+ +D+ + Q L + + + E+ L
Sbjct: 2314 TLRQKAQVE--QELTTLRLQLEETDHQKNLLDE---ELQRLKAEATEAARQRSQVEEELF 2368
Query: 3911 NLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSA-ICSTAQRMYQSLEHELQKHVS 3969
+++++ + L L+A+++ A + KD+ + A++M Q E + V+
Sbjct: 2369 SVRVQMEEL-----SKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423
Query: 3970 RQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKH-FRALQEQAR--TYLDLLCSMC 4026
Q+ + Q + DL RA A K +K +A+QE R +LL
Sbjct: 2424 AQEAARLRQ----LAEEDLAQ------QRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473
Query: 4027 DLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMK 4086
+L+ + +D EQ +Q + Q + E + + E+ + ++ M
Sbjct: 2474 ELAQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530
Query: 4087 RRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQ 4146
R + E + AQ Q ++ +KL + + + V L + + +H + L +
Sbjct: 2531 RAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH-DAERLREA 2588
Query: 4147 WLDLCRQSNNL-----CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTA 4201
+L R+ L LQ + + +T + + + F +E D+L + +
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER---- 2644
Query: 4202 VHLEALK-KLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDL 4260
+E K KL Q+ + L++++Q+ + + + + LV +R + E+
Sbjct: 2645 -FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASM-EEARRRQHEAEEG 2702
Query: 4261 IKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQ 4293
++RK + L++L + + +EL+ AEE Q
Sbjct: 2703 VRRKQE----ELQQLEQQRRQQEELL--AEENQ 2729
Score = 85.5 bits (210), Expect = 2e-15
Identities = 304/1640 (18%), Positives = 629/1640 (38%), Gaps = 242/1640 (14%)
Query: 586 EAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQ 645
E E + + + +W+ + + + LE++ Y + L AWL+DA + Q
Sbjct: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1369
Query: 646 SENAKKDFFRNLPHWIQQHTAM---NDAGNFLIETCDEMVS------RDLKQQLLLLNGR 696
+ + + ++Q A+ + +E C +D + QL+ +
Sbjct: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1429
Query: 697 WRELFMEVKQYAQADEMDRMKKEYTDC---VVTLSAFATEAHKKLSEPLEVSFMNVKLLI 753
+ K+ + + +EY D L+ ++ K +SE L +L
Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489
Query: 754 QDLEDIEQRVPVMDA--QYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECYS 811
Q + +R+ ++A + + AH K + E KE+ +++E++ + +E
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAV 1546
Query: 812 PLLYESQQLLIPLEELE-----------KQMTSFYDSLGKINEIITVLE----------- 849
+ + + L++L +Q + S +I E I V+
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG 1606
Query: 850 -------------REAQSSALFKQKHQELLACQ---ENCKKTLTLIEKGSQ---SVQKFV 890
EA++ Q+ E L Q E+ +K +E S+ +
Sbjct: 1607 GAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAR 1666
Query: 891 TLSNVLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMK--------KFEES 942
L+ ++ RLQ + A+ + Q+ V++ + +ET R + F E
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 943 RAELEKVLR---IAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQ 999
A+LE+ L+ +A L E+ + + E + +R L + +E + +
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 1000 EQQGLQE--AVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMP 1057
E+ Q+ A + KQ ++ + EA + + + + E EL+++ +L
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREA------RRRGKAEEQAVRQRELAEQELEKQRQLAE 1839
Query: 1058 QEGSEKIIKEHRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRA 1117
+++ E + + E++ QL+EE +L R+ T + R
Sbjct: 1840 GTAQQRLAAEQEL-IRLRAETEQGEQQRQLLEEELARLQ-REAAAAT---------QKRQ 1888
Query: 1118 AIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEI 1177
+++ K+ + + +R E S ST+E + ++ EA G + EE
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESR--STSEKSKQRLEAEA------GRFRELAEE- 1939
Query: 1178 RNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSN 1237
+RL+ L E + + D + + + + L L+ +
Sbjct: 1940 --------------AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI------ 1979
Query: 1238 FGDCVQYKEIVKNSLEELISGSKEVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKR 1297
G+ + K + +L+E KE + + + L + F+ ++L ++ + K
Sbjct: 1980 -GEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQRRRL-------EEQAAQHKA 2026
Query: 1298 DVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKE 1357
D+++++AQ ++ EL + + ++ R R + E I +E+ K
Sbjct: 2027 DIEERLAQLRKA-------SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 1358 TVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASE-IPLG 1416
+ L + S+ E ++L S+ EQ + + R +A + E +EA E +
Sbjct: 2080 ELELELGRIRSNAE--------DTLRSK-EQAELEAARQRQLAAEEERRRREAEERVQKS 2130
Query: 1417 PQNKQLLQQQAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL 1476
++ +Q K+ E+V++L+ +EE + E + + + L + +K L
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE------SARQLQLAQEAAQKRL 2184
Query: 1477 NALETSSS-AMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKA--KL 1533
A E + + A+ + +++ T+Q+ +S L + G E A+ A+ E AR++A +
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE---EAEEARVQAEREA 2241
Query: 1534 TQIRRYGEELREHAQCLEGTILGHLSQQQKFE--------ENLRKIQQSVSEFEDKLAVP 1585
Q RR EE Q E Q E E R+ Q + K A
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Query: 1586 IKICSSATETYKVLQEHMDLCQALESLSSAITAFSASA----RKVVNRDSCVQEAAALQQ 1641
++ + L++ + Q L +L + ++ + EAA +
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 1642 QYEDILRRAKERQTALENLLAHWQRLEKELSSFL--------TWLERGEAKASSPEMDIS 1693
Q E+ L + + L L A R+E E + + +L+ K + +
Sbjct: 2362 QVEEELFSVRVQMEELSKLKA---RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418
Query: 1694 ADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVAS--KDDVKMMKLHLEQLDE 1751
V + +L Q + ++ Q + K+L+ K A+ K + ++++ E E
Sbjct: 2419 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2478
Query: 1752 RWRDL--------PQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISI 1803
+ R L Q+ + F +++ AE Q+ E+ + +KL ++E+ +
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAE-AERLKLRVAEMSRAQARAE 2537
Query: 1804 MDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEA 1863
D Q R + A E+ K + LA + + L + + +++ + EA
Sbjct: 2538 EDAQ----RFRKQAEEIGEKLHRTE-----LATQEKVTLVQTLEIQRQQSDHDAERLREA 2588
Query: 1864 SQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNA 1923
+ER + L A+ LQ + ++Q Q ++ T ++ +S L EKD LQ
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQ-EQLLQETQAL--QQSFLSEKD--SLLQRE 2643
Query: 1924 KALESAAVSLDGI----LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
+ +E L+ + ++KAQ L+ Q+ +L +E + +Q E
Sbjct: 2644 RFIEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARR----RQHE 2698
Query: 1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHE 2039
A+ +K+E L+ +E ++R +E L Q L+++L++ + +H
Sbjct: 2699 AEEGV-------RRKQEELQQLE--QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHS 2749
Query: 2040 HELCWLKDKAKQIAQ-------KDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLI 2092
E+ A Q+A +D P + E E ++D +R + + Q G++
Sbjct: 2750 EEV-----TASQVAATKTLPNGRDALDGPAAEAE---PEHSFDGLRRKVSAQRLQEAGIL 2801
Query: 2093 DLMREYQNLKSAVSKVLENA 2112
E Q L + V E A
Sbjct: 2802 S-AEELQRLAQGHTTVDELA 2820
Score = 73.9 bits (180), Expect = 6e-12
Identities = 256/1325 (19%), Positives = 496/1325 (37%), Gaps = 215/1325 (16%)
Query: 7422 QQRAHELFQAEMFSRQQILHSIIIDGQRLLEQ-GQVD-DRDEFNLKLTLLSNQWQGVIRR 7479
QQ + + E+ Q++ G+RL ++ G+ D + + + ++ L +WQ V+ +
Sbjct: 1279 QQPTFDALRDELRGAQEV-------GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1331
Query: 7480 AQQRRGIIDSQIRQWQRYREMAEKLRKWL-------VEVSYLPMSGLGSVPIPLQQARTL 7532
R+ ++ RQ + YRE A+ L WL ++ +P++ +V L+Q + L
Sbjct: 1332 TDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1391
Query: 7533 FDEVQ-FKEKV--FLRQQGSYILTVEAGKQLLLSADSGAE-AALQAELAEIQEKWKSASM 7588
+E++ EKV R YI ++ + L++ + E A A+ ++Q +S
Sbjct: 1392 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1451
Query: 7589 RLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELEN 7648
+ + + L + K I+++L ++ EE AEQ R +E E
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRM-------------EEEERLAEQQRAEERER 1498
Query: 7649 AVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELC--HQLSLRRQQIGE 7706
Q L + A A+ E EL QR EE+ + ++ QQ
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAE-----REAKELQQRMQEEVVRREEAAVDAQQQKR 1553
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQNGDILIEEMIE--KLKKDYQEEIAIAQENKIQ 7764
+ E ++ E +++ ++ + IEE I +L+ + E E ++Q
Sbjct: 1554 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1613
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDL---IAARVK-------KLKETLV 7814
+ A+A E E +V D Q +A+RVK + + L
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 7815 AVQQLDKNMSSLRTWLAHIESELAKPI-----VYDSCNSEEIQRK----LNEQQELQRDI 7865
A+++L L E E A+ + E+Q K + +L+R +
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 7866 EKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 7925
++ VA + E AE + ++ RW+ ++ RL+ EE
Sbjct: 1734 QEEHVAVAQLREEAE------RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787
Query: 7926 TWRLWQKFL---DDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEELKKFEAFQRQVHECL 7982
+ QK L + + E+ + + R + +A++EL+K QRQ+ E
Sbjct: 1788 VAQ--QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK----QRQLAEGT 1841
Query: 7983 TQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFIGQREEF 8042
Q +RLA E L+ +G Q+ L++ + + R +R+E
Sbjct: 1842 AQ--------QRLAAE---QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 8043 ETARDSILVWLTEMDLQLTNIEHFS---------------------------------EC 8069
E + + + E S E
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1950
Query: 8070 DVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEEL--DELRRYCQE 8127
Q ++ + A +Q E++ A GE K+E + A+ E+E + LRR ++
Sbjct: 1951 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE-AEIALKEKEAENERLRRLAED 2009
Query: 8128 VFGRVERYHKKLIRLPLPDDE-----HDLSDRELELEDSAALSDLHWHDRSADSLLSPQP 8182
+ R ++ + +E SD ELE + L + + +L+ +
Sbjct: 2010 EAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 2069
Query: 8183 S--------SNLSLSLAQPLRSERSGRDTPASVDSIPLEWDHDYDLS-------RDLESA 8227
S + L L L R + DT S + LE L+ R+ E
Sbjct: 2070 SFEKAAAGKAELELELG---RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126
Query: 8228 MSRALPSEDEEGQDDK---------DFYLRGAVGLSDVMIPESPEAYVKLTENAIKNTSG 8278
+ ++L +E+E + K + A L + ES E A K
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 8279 DHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE-LDTSYKGYMKLLGECSSSID 8337
+ A ++Q + L + Q Q + +R + + + + ++ E + S
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246
Query: 8338 SVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELLQAQALSKELRMK--------- 8388
V+ E + EE + + ++ +AQA LR K
Sbjct: 2247 QVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2306
Query: 8389 ------QNLQKWQQFNSDLNSIWAWLGDT-------EEELEQL---------QRLELSTD 8426
Q L++ Q +L ++ L +T +EEL++L QR ++ +
Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366
Query: 8427 IQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKESRDLQDRLSQMNGRWDR 8485
+ ++ +Q+++L +L+ ++ +A+IL + F Q ++++ + + + ++++
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426
Query: 8486 VCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHK 8545
L R L ++ L Q + + E + + K + V + L AE
Sbjct: 2427 AARL----RQLAEEDLAQQRA----------LAEKMLKEKMQAVQEATRLKAE------A 2466
Query: 8546 QLMQIKHELLESQLR--VASLQDMSCQLLVNAEGTD-CLEAKE----KVHVIGNRLKLLL 8598
+L+Q + EL + Q R + M+ QL +G LEA+ ++ RLKL +
Sbjct: 2467 ELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRV 2526
Query: 8599 KEVSR 8603
E+SR
Sbjct: 2527 AEMSR 2531
Score = 61.2 bits (147), Expect = 4e-08
Identities = 366/2011 (18%), Positives = 779/2011 (38%), Gaps = 324/2011 (16%)
Query: 6049 EAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLEL 6108
E++ C + L +I ++ A +VH L L+ K+ A + A ++ E
Sbjct: 1116 ESRCQRCISELKDIRLQLEACETRTVHRLRLPLD-----KEPARECAQRIA-------EQ 1163
Query: 6109 QRALHDKQLNMQGTAQEKEESDVDLTATQ-SPGVQEWLAQARTTWTQQRQSSLQQQKELE 6167
Q+A + + +G A+ E++ L + SP ++ T + Q ++ +
Sbjct: 1164 QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ--VRSLSAIY 1221
Query: 6168 QELAEQKSLLRSVASRGEEILIQHSAA--ETSGDAGEKPDVLSQELGMEGEKSSAEDQMR 6225
E + SL+ EE+L H E P++ + + ++ ++ AE Q +
Sbjct: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ-Q 1280
Query: 6226 MKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQD-KSAVTSLL 6284
+++L E Q++ + + ++ E+ DV + + V LL
Sbjct: 1281 PTFDALRDELRGAQEVGERLQQRHGER------------------DVEVERWRERVAQLL 1322
Query: 6285 DGLNQAFEEVSSQSGGAKRQSIHLEQKLY---DGVSATSTWLDDVEERLFVATALLPEET 6341
+ ++ V +Q+ +R+ L ++L + WL D R A+ ++
Sbjct: 1323 E----RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS 1378
Query: 6342 ETC---LFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLD 6398
+ L ++ L ++I+ E++++ + Q + I+D L+ + L+
Sbjct: 1379 QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYI-------NAIKDYELQLVTYKAQLE 1431
Query: 6399 SVVNQ-RCHQMKERLQQILNFQNDLKVLFTSLAD--NKYII--------LQKLANVFEQP 6447
V + + +++ + ++ DL+ ++ L ++YI +++ + EQ
Sbjct: 1432 PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQ 1491
Query: 6448 VAEQIEAIQQAEDGLK----------------EFDAGIIELKRRGDKLQVEQPSMQELSK 6491
AE+ E + + E L+ E +A ++ + + + ++ E+ ++ +
Sbjct: 1492 RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ 1551
Query: 6492 LQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEE 6551
+ + +EL + S + + ER+ + + + + ++ ++ ++ E
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611
Query: 6552 IQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGV 6611
+Q L + +E E L R++ + Q++ Q EL ++ A + A ++
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 6612 ELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEY 6671
L+ + E +E ++ L RQ EV + V L E R + Q ++S E
Sbjct: 1671 ALQALEELRLQAEEAERRL-RQAEVERARQVQVAL--ETAQRSAE--AELQSKRASFAEK 1725
Query: 6672 QPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQS 6731
+L + L + + + ++ + E + Q E + + +EL R + R +
Sbjct: 1726 TAQLERSLQE-EHVAVAQLREEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRL 1783
Query: 6732 ESADLIHWLQSAKDRLEFWTQQSVTVPQ-----ELEMVRDHLNAFLEFSKEVDAQSSLKS 6786
++ ++ A+ E +++ + E + VR A E K+
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843
Query: 6787 SVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAIS 6846
L+ +L+RL+ +T + ++ + L A +K +L+ + R +
Sbjct: 1844 QRLAAEQELIRLR-AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902
Query: 6847 EVMSWISLME----NVIQKDEDNIKNSIG-YKAIHEYLQKYKGFKIDINCKQLTVDFVNQ 6901
+++ + E + +K + ++ G ++ + E + + + ++
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR-------- 1954
Query: 6902 SVLQISSQDVESKRSD-KTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
Q++ +D +R++ + AE+L A+ ++ ++ K + L E +E E
Sbjct: 1955 ---QLAEEDAARQRAEAERVLAEKLAAIGEATRL-------KTEAEIALKEKEAENERLR 2004
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQD-LEDLIKAKEKEVEKIEQNGLALIQ 7019
+ E Q+ R+ +QA+ A D ++ L L KA + E+E+ Q GL
Sbjct: 2005 RLA-------EDEAFQRRRLEEQAAQHKA--DIEERLAQLRKASDSELER--QKGL---- 2049
Query: 7020 NKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEAR 7079
V TLR+ Q V ++ + K +F+K + E
Sbjct: 2050 ---------VEDTLRQRRQ------------------VEEEILALKASFEKAAAGKAELE 2082
Query: 7080 YSLSRFRL----LTGSLEAVQVQVDNLQNLQDDLEKQERS----LQKFGSITNQLLKECH 7131
L R R S E +++ + L + E++ R +QK + + ++
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 7132 PPVTET--LTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQED 7189
+ E L ++E +E A QLQ ++ Q +R + K A VQQ+E
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFAVQQKEQ 2200
Query: 7190 RTNELLKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAAS 7249
+ L+ Q D L+G ++ E E+ + Q + AA
Sbjct: 2201 ELQQTLQQE--------------QSVLDQLRGEA---EAARRAAEEAEEARVQAEREAAQ 2243
Query: 7250 AIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+ + + + A EQA + Q A E K E A +AE+ Q
Sbjct: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAA-----EKLRKEAEQEAARRAQAEQAALRQKQ 2298
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLD-RLNELGYRLPLNDKEIKRMQNLNRHWSL 7368
+ +++ ++ E+ Q + L +L E ++ L D+E++R++
Sbjct: 2299 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK-------A 2351
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHEL 7428
+++ + S+++ L + +E+ + + L + N Q L+++
Sbjct: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMK 2411
Query: 7429 FQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIID 7488
AE +R + + RL + + D + L +L + Q V Q +
Sbjct: 2412 QVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEKMLKEKMQAV-----QEATRLK 2463
Query: 7489 SQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQG 7548
++ Q+ +E+A++ + L E Q A+ L +E Q ++
Sbjct: 2464 AEAELLQQQKELAQEQARRLQEDKE-------------QMAQQLAEETQGFQRT------ 2504
Query: 7549 SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCE 7608
L E +QL +SA++ AE++ Q + + + R +Q +++ L + E
Sbjct: 2505 ---LEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL---HRTE 2558
Query: 7609 KGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLKDTLS 7668
+ + ++T + + QS DH AE++R + + +L K+ L
Sbjct: 2559 LATQEKVTLVQTLEIQRQQS--DHD----AERLR------------EAIAELEREKEKLQ 2600
Query: 7669 AYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM 7728
A + + +E ++ +Q+ E+L + +Q SEK+ L Q
Sbjct: 2601 Q--EAKLLQLKSEEMQTVQQ--EQLLQETQALQQSF---------LSEKDS-----LLQR 2642
Query: 7729 ESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEIEYKL 7788
E IE+ KL++ +Q+E+A AQ+ + + Q+ +++ + AS E +
Sbjct: 2643 ER--------FIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR- 2693
Query: 7789 GKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNS 7848
R QH + V++ +E L QQL++ LA +
Sbjct: 2694 -----RRQHEAE---EGVRRKQEEL---QQLEQQRRQQEELLAE--------------EN 2728
Query: 7849 EEIQRKLNEQQELQRDIEKHSTGV-ASVLNLCEVLLHDCDAC---ATDAECDSIQQATRN 7904
+ ++ +L +E R HS V AS + + L + DA A +AE + +
Sbjct: 2729 QRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE------HS 2782
Query: 7905 LDRRWRNICAMSMERR--LKIEETWRLWQ--KFLDDYSRFEDWLKSSERTAAFPSSSGVI 7960
D R + A ++ L EE RL Q +D+ +R ED + + S +G++
Sbjct: 2783 FDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRS---SIAGLL 2839
Query: 7961 YTVAKEELKKFEAFQRQVHECLTQLELINKQ 7991
E+L + A QRQ+ T L L+ Q
Sbjct: 2840 LKATNEKLSVYAALQRQLLSPGTALILLEAQ 2870
Score = 41.2 bits (95), Expect = 0.046
Identities = 36/188 (19%), Positives = 77/188 (40%), Gaps = 24/188 (12%)
Query: 8266 VKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGY 8325
+K I+ T G L + QL +A ++ T PEL+ +
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEA---------------QAVPATLPELEATKASL 1269
Query: 8326 MKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTET--------QTAGVIDRWELLQ 8377
KL + + + L +L+ +E H + A +++RW+ +
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329
Query: 8378 AQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQIKKL 8437
AQ ++ ++Q ++ + + + + AWL D EQ+Q + L+ D Q + Q+++
Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA-DSQAVREQLRQE 1388
Query: 8438 KELQKAVD 8445
+ L + ++
Sbjct: 1389 QALLEEIE 1396
Score = 40.4 bits (93), Expect = 0.078
Identities = 126/677 (18%), Positives = 251/677 (37%), Gaps = 46/677 (6%)
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
E + G + +Q LL + ++ + +L L L P+ D
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL--D 1149
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
+ E +++ EQQ+ Q ++E GVA + E +L + S + T
Sbjct: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209
Query: 7905 LDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVA 7964
+ R++ A+ +E+ I R Q + E+ LK ++ A
Sbjct: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269
Query: 7965 KEELKKFEAFQRQVHECLTQLELINKQYRRLAREN--RTDSACSLKQMVHEGNQRWDNLQ 8022
K+ + EA Q +L + RL + + R ++ V + +RW +
Sbjct: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329
Query: 8023 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQ 8082
+ R L+ Q + + D + WL + + I+ D QA +QL+
Sbjct: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR--- 1386
Query: 8083 QEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLI-- 8140
QE +L +E+I G E+++E +R+ ++ ++ Y +L+
Sbjct: 1387 QEQAL----LEEIERHG----------------EKVEECQRFAKQYINAIKDYELQLVTY 1426
Query: 8141 RLPLPDDEHDLSDRELELEDSAALS---DLHWHDRSADSLLSPQPSSNLSLSLAQPLRSE 8197
+ L +++ + + DL H +L S Q +S +L + E
Sbjct: 1427 KAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRMEEEE 1485
Query: 8198 RSGRDTPASVDSIPLEWDHDYDLSRDLESAMSRALPSEDEEGQDDKDFYLRGAVGLSDVM 8257
R A E + + R L A ++A + E ++ + V +
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545
Query: 8258 IPESPEAYVKLTENAIKNTSGDHSALESQIRQLGKALDDSRFQIQQTENIIRSKTPTGPE 8317
+ ++ + + E + + ++++ RQ +A + SR +I++ ++R +
Sbjct: 1546 V-DAQQQKRSIQEELQQLRQSSEAEIQAKARQ-AEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 8318 LDTSYKGYMKLLGECSSSIDSVKRLEHKLKEEEESLPGFVNLHSTETQTAGVIDRWELL- 8376
+G ++ L + ++ KR + +EE E L V S + A V EL
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKR---QAQEEAERLRRQVQDESQRKRQAEV----ELAS 1656
Query: 8377 QAQALSKELRMKQN-LQKWQQFNSDLNSIWAWLGDTE-EELEQLQ-RLELSTDIQTIELQ 8433
+ +A ++ R KQ LQ ++ L E E Q+Q LE + ELQ
Sbjct: 1657 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1716
Query: 8434 IKKLKELQKAVDHRKAI 8450
K+ +K +++
Sbjct: 1717 SKRASFAEKTAQLERSL 1733
>gi|19923599 calmin [Homo sapiens]
Length = 1002
Score = 259 bits (663), Expect = 6e-68
Identities = 167/357 (46%), Positives = 219/357 (61%), Gaps = 26/357 (7%)
Query: 18 MQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPC 77
+Q LQ E+E VQKRTFT+WIN HL K PP+ V DLF D++DG L+ALLEVLSG+ L
Sbjct: 23 VQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSGRNLLH 82
Query: 78 EQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTII 137
E RI + NI ALKFLE S +KLV+I++ +IADG PS+VLGL+W II
Sbjct: 83 EYKSSSHRIFRLNNIAKALKFLED-------SNVKLVSIDAAEIADGNPSLVLGLIWNII 135
Query: 138 LYFQIEELTSNLPQ---LQSLSSSASSVDSIVSSETPSPPSKRKV--TTKIQGNAKKALL 192
L+FQI+ELT NL + SLS + DS SS P+P ++R V + K Q A KALL
Sbjct: 136 LFFQIKELTGNLSRNSPSSSLSPGSGGTDSD-SSFPPTPTAERSVAISVKDQRKAIKALL 194
Query: 193 KWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTI 252
WVQ K G+ V+DF SWRSG+AF +VI AI P LVD++ S RENLE AF+I
Sbjct: 195 AWVQRKTRKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSI 253
Query: 253 AETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSF 312
A+ L IPRLL+PED+ VD PDE+SIMTYVAQFL+ +P++ + D + D+ +P +F
Sbjct: 254 AQDALHIPRLLEPEDIMVDTPDEQSIMTYVAQFLERFPELE--AEDIFDSDKEVPIESTF 311
Query: 313 ANSVQNFKREDRVIFKEMKVWIEQFERDLT------RAQMVESNLQDKYQSFKHFRV 363
+ ++ +F V E ER T + + DK +S K FR+
Sbjct: 312 VRIKETPSEQESKVF----VLTENGERTYTVNHETSHPPPSKVFVCDKPESMKEFRL 364
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 237 bits (605), Expect = 3e-61
Identities = 427/2098 (20%), Positives = 813/2098 (38%), Gaps = 414/2098 (19%)
Query: 19 QRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCE 78
++LQDE+E VQK+TFTKW+NSHLA+ + DL+ D++DG L+ LLEVLSG++LP
Sbjct: 33 KQLQDEREAVQKKTFTKWVNSHLARVS--CRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90
Query: 79 QGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIIL 138
RM RIH + N+ AL+FL+ ++ + L N+ S DI DG + LGL+WTIIL
Sbjct: 91 TKGRM-RIHCLENVDKALQFLKEQR-------VHLENMGSHDIVDGNHRLTLGLIWTIIL 142
Query: 139 YFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVTTKIQGNAKKALLKWVQYT 198
FQI++ +S ET K+ +AK ALL W Q
Sbjct: 143 RFQIQD---------------------ISVETEDNKEKK--------SAKDALLLWCQMK 173
Query: 199 AGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELG 258
+ + +F SWR G+AF+++IH RP+L+D + +K + NL++AF +AE LG
Sbjct: 174 TAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLG 233
Query: 259 IPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQN 318
+ +LLDPED+ VD PDEKSI+TYV + ++ + + +G+ ++L ++
Sbjct: 234 LTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEK 293
Query: 319 FKREDRVIFKEMKVWIEQFERDLTRAQMVES--NLQDKYQSFKHFRVQYE----MKRKQI 372
++ + ++ WIEQ L + S +Q + Q+F +R + ++ +
Sbjct: 294 YES----LASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNL 349
Query: 373 EHLIQPLH-------------RDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLG 419
E L+ + R+GKL D + ++W+R L+K+
Sbjct: 350 EVLLFTIQSKMRANNQKVYMPREGKLISD---INKAWER-----------LEKA------ 389
Query: 420 TIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNTD--------------- 464
+ E+ALR E+ Q+ E+ A RK + L
Sbjct: 390 -----EHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAV 444
Query: 465 --AHKRAFHEIYRT------RSVNGIPVPPDQLEDMAERFHFVSSTS------------- 503
A K+ HE T V + +LE AE +H + +
Sbjct: 445 EAATKK--HEAIETDIAAYEERVQAVVAVARELE--AENYHDIKRITARKDNVIRLWEYL 500
Query: 504 -ELHLMKMEFLELKYRLLSLLV--------LAESKLKSWIIKYGRR-ESVEQLLQNYVSF 553
EL + + LE+ L + + E K+ YG+ VE LLQ + +
Sbjct: 501 LELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKH-TL 559
Query: 554 IE-----NSKFFEQYEVTYQILKQTAEMYVKADGSV-EEAENVMKFMNETTAQWRNLSVE 607
+E ++ + Q E Y D V + M+F + Q L+ E
Sbjct: 560 VEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQ---LAAE 616
Query: 608 VRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAM 667
R+ LEE W ++ +A + W+ + EK+L+ + K ++ + +H A
Sbjct: 617 ---RRARLEESRRLW-KFFWEMAEEEGWIREKEKILSSDDYGKD--LTSVMRLLSKHRAF 670
Query: 668 ND-----AGNF--LIETCDEMV------SRDLKQQLLLLNGRWRELFMEVKQYAQADEMD 714
D +G+F I+ ++M+ S ++++++ + +W A +++
Sbjct: 671 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW----------ANLEQLS 720
Query: 715 RMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIIT 774
++K+ + L F +A +DI DA I
Sbjct: 721 AIRKKRLEEASLLHQFQADA----------------------DDI-------DAWMLDIL 751
Query: 775 KTAHLITKESPQEEGKEMFATMSKLKEQLTKVKEC--YSPLL--YESQQLLIPLEELEKQ 830
K S + G + ++T S +K+ +E Y P L Q +P E E
Sbjct: 752 KIV------SSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESP 805
Query: 831 MTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFV 890
D G+++ I + A+ + L KQ Q+ TL L + S++ +
Sbjct: 806 -----DVRGRLSGIEERYKEVAELTRLRKQALQD----------TLALYKMFSEADACEL 850
Query: 891 TLSNVLKHFDQTRLQRQIADIHV---AFQSMVKKTGDWKKHVETNSRLMKKFEESRAELE 947
+ + + ++ ++ D+ V F+S+ + + V +++ ++ S E
Sbjct: 851 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 910
Query: 948 KVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEA 1007
K ++ Q+ L + F +L R +A L A L E +
Sbjct: 911 KEIKAQQDKLNTRWSQ----------FRELVDRKKDALLSALSIQNYHLECNETKSWIRE 960
Query: 1008 VRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKE 1067
K+ + +DL + + + R L ++E ++L +E +EK+ E
Sbjct: 961 KTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKE--------AEKLESE 1012
Query: 1068 HRVFFSDKGPHHLCEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLM 1127
H ++ ++ L + D TLK A++
Sbjct: 1013 HP------------DQAQAILSRLA-------EISDVWEEMKTTLKNREASLG------- 1046
Query: 1128 EDPDKWKDYTSRFSEFSSWISTNETQLKG-------IKGEAIDTANHGEVKRAVEEIRNG 1180
+ K + + +F SW+S +T + + E + T H +K ++
Sbjct: 1047 -EASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLT-QHENIKNEIDNYEED 1104
Query: 1181 VTK---------RGET---LSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLL 1228
K +G+T +L+ RL+ L + NE K + L S A L
Sbjct: 1105 YQKMRDMGEMVTQGQTDAQYMFLRQRLQALD--TGWNELHKMWENRQNLLSQSHAYQQFL 1162
Query: 1229 ---SEVEKMLSNFGDCVQYKEI-------------------VKNSLEELIS--------- 1257
+ E L+N + + E+ ++ EE I+
Sbjct: 1163 RDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRL 1222
Query: 1258 ------GSKEVQEQAEKILD--TENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQG 1309
S +QE+ + I D +N A +LL+ + + + +D Q+ +
Sbjct: 1223 VSDGNINSDRIQEKVDSIDDRHRKNRETASELLM-RLKDNRDLQKFLQDCQELSLWINEK 1281
Query: 1310 EGGLPDRGHEELRKLES----------------------TLDGLERSRERQERRIQVTLR 1347
D ++E R L S +G++ E+ E V +
Sbjct: 1282 MLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEK 1341
Query: 1348 ------KWERFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELE---QTKEFSKRTES 1398
WE E+ +T + LF + S + L+ LE Q+ ++ K S
Sbjct: 1342 LTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTS 1401
Query: 1399 IAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT----LEEDIKTMEMVK-- 1452
+ + + +++ + + + LQ QA+++ ++ K ++ L K ME+++
Sbjct: 1402 VNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPL 1461
Query: 1453 ---------TKWDH-FGSNFETLSVWITEKEKELNALETSSSAMDMQ--ISQIKVTIQEI 1500
+K H F + E +W+ E+ + + + +Q I + + +EI
Sbjct: 1462 NERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEI 1521
Query: 1501 ESKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYG----EELREHAQCLEGTILG 1556
+ I + E +Q+ ++ + I+ +L +++ EE + + LE
Sbjct: 1522 QGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEE---A 1578
Query: 1557 HLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAI 1616
H +QQ F+ + S E K SA +L++H L QA+E + +
Sbjct: 1579 HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAV---SMLKKHQILEQAVEDYAETV 1635
Query: 1617 TAFSASARKVVNRDSCVQEAAALQQQ-----YEDILRRAKERQTALENLLAHWQRLEKEL 1671
S ++R +V E +++Q Y + A+ER+ L+ +Q L +E+
Sbjct: 1636 HQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQ-LNREV 1694
Query: 1672 SSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLF 1731
W+ E A S E+ + V + E A + Q + L + L
Sbjct: 1695 DDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQER-VDTVNHLADELI 1753
Query: 1732 SVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLF 1791
+ D + + + L+E W DL ++I+ R L + H+ + + + ++ ++
Sbjct: 1754 NSGHSDAATIAEWK-DGLNEAWADLLELIDTRTQILAASYELHKFYHD---AKEIFGRIQ 1809
Query: 1792 LSELQTTSEISIMDHQVALTRHKDHAA---EVESKKGELQSLQGHLAKLGSLGRAEDLHL 1848
+ E+ D T + H ++++ +++ LQ A+L + +
Sbjct: 1810 DKHKKLPEELG-RDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADD 1868
Query: 1849 LQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNK 1906
+Q + + + ++ E R++ L + + + + ++ + + + K
Sbjct: 1869 IQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEK 1926
Score = 124 bits (312), Expect = 3e-27
Identities = 308/1695 (18%), Positives = 668/1695 (39%), Gaps = 222/1695 (13%)
Query: 6563 FQGLESHMILTETLFRKIISFAVQKETQFHTELM------AQASAVLKRAHKRGVELEYI 6616
F E H+ LT+ L + IS E T ++ ++ A+ + G L+
Sbjct: 225 FNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNA 284
Query: 6617 LETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQ---- 6672
+ET +++ + S LE +E +I + N + + + Q + N Y+
Sbjct: 285 IETEKMIEKYESLASDLLEWIEQTI-----IILNNRKFANSLVGVQQQLQAFNTYRTVEK 339
Query: 6673 PKLYQVLDDGKRLLISISC------------------SDLESQLNQLGECWLSNTNKMSK 6714
P + + + LL +I SD+ +L + +
Sbjct: 340 PPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRN 399
Query: 6715 ELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEF 6774
EL R E + + R+ ++A WL S RL +P + H
Sbjct: 400 ELIRQEKLEQLARRFDRKAAMRETWL-SENQRLVSQDNFGFDLPAVEAATKKHE----AI 454
Query: 6775 SKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ- 6833
++ A +V++ +L D + + + W LL + A +++L
Sbjct: 455 ETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMN 514
Query: 6834 LQMDKLPSRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQ 6893
L + K+ + +M W+ M+ V+ +D K+ +G + + LQK+ + DI +
Sbjct: 515 LGLQKIFQE--MLYIMDWMDEMK-VLVLSQDYGKHLLG---VEDLLQKHTLVEADIGIQA 568
Query: 6894 LTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESW 6953
V VN S + ++ K D +++ M +Q L L E+ LE W
Sbjct: 569 ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 628
Query: 6954 SEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQN 7013
+ + + W +EK L D SV L + ED + + E+ +
Sbjct: 629 KFFWEMAE-EEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKE 687
Query: 7014 GLALIQNKKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINS 7073
G +I + S + + + + WANL+ QL + K L++ S
Sbjct: 688 GEDMIAEEHFG-SEKIRERIIYIREQWANLE----QLSAIRKKRLEEASL---------- 732
Query: 7074 YLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPP 7133
L +F+ ++A + + + + D+ E S T L+K+ H
Sbjct: 733 --------LHQFQADADDIDAWMLDILKIVS-SSDVGHDEYS-------TQSLVKK-HKD 775
Query: 7134 VTETLTN---TLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR 7190
V E + N TL ++ + + L +E AE L + +RYK+ ++ Q +D
Sbjct: 776 VAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQD- 834
Query: 7191 TNELLKAATNKDIAD---DEVATWIQDCN--DLLKGLGTVK--------------DSLFF 7231
T L K + D + DE W+ + + L+ L ++ +
Sbjct: 835 TLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAV 894
Query: 7232 LHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSLE 7291
++++ QL S I++ Q L+ + + +++ +L + L + +
Sbjct: 895 VNQIARQLMHSGHPSEKE-IKAQQDKLNTRWSQFRELVDRKKDALLSA-LSIQNYHLECN 952
Query: 7292 ALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPL 7351
++WI E ++++ +DL+ + +L G ++ L L + +L
Sbjct: 953 ETKSWIREKTKVIESTQDL-GNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLES 1011
Query: 7352 NDKE-----IKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQ 7406
+ + R+ ++ W + + R + L + Q FL + + +L +T+
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGE-ASKLQQFLRDLDDFQSWLSRTQT 1070
Query: 7407 KLAVEISGNY----QHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEF 7462
+A E N + LL Q HE + E+ + ++ + G+ ++ QGQ D + F
Sbjct: 1071 AIASEDMPNTLTEAEKLLTQ---HENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMF 1126
Query: 7463 -NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGS 7521
+L L W + + + R+ ++ SQ +Q++ ++ +L Y+
Sbjct: 1127 LRQRLQALDTGWNELHKMWENRQNLL-SQSHAYQQFLRDTKQAEAFLNNQEYVLAHT--E 1183
Query: 7522 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQE 7581
+P L+ A + + + VE G++L+ + ++ +Q ++ I +
Sbjct: 1184 MPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR-IQEKVDSIDD 1242
Query: 7582 KWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE---LHA 7638
+ + + E +L LKD +K + D E +K+ + ++E LH+
Sbjct: 1243 RHR----KNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHS 1298
Query: 7639 EQMRCKELENAVGS---WTDDLTQ--LSLLKDTLSAYISADDISILNERVELLQRQWEEL 7693
+ ++ + + S W D + + + L+ + + +++ E++ L + WE L
Sbjct: 1299 KWLKHQAFMAELASNKEWLDKIEKEGMQLISE------KPETEAVVKEKLTGLHKMWEVL 1352
Query: 7694 CHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNG---DILIEEMIEKLKKD 7750
+ Q++ + N+ +F++ +L +WL +ES++ + D+ ++ K ++
Sbjct: 1353 ESTTQTKAQRLFDA-NKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQM 1411
Query: 7751 YQEEIAIAQENKIQLQQMGERLAKASHESKAS-EIEYKLGKVNDRWQHLLDLIAARVKKL 7809
+ ++ + ++ +LQ + L S E K++ E++ K V ++ LL+ + R
Sbjct: 1412 LENQMEVRKKEIEELQSQAQAL---SQEGKSTDEVDSKRLTVQTKFMELLEPLNER---- 1464
Query: 7810 KETLVA---VQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIE 7866
K L+A + Q ++++ W+ LA + N + +Q + + Q LQ++I+
Sbjct: 1465 KHNLLASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGH-NLQTVQLLIKKNQTLQKEIQ 1522
Query: 7867 KHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEET 7926
H + + + ++ D + + +A I+Q +L + W + + +R ++EE
Sbjct: 1523 GHQPRIDDIFERSQNIVTDSSSLSAEA----IRQRLADLKQLWGLLIEETEKRHRRLEEA 1578
Query: 7927 WRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGVIYTVAKEE----------LKKFEAFQR 7976
R Q++ D + E W+ E +Y +++E+ LKK + ++
Sbjct: 1579 HRA-QQYYFDAAEAEAWMSEQE-----------LYMMSEEKAKDEQSAVSMLKKHQILEQ 1626
Query: 7977 QVHECLTQLELINKQYRRLARENRTDSACSLKQMVHEGNQRWDNLQKRVTSILRRLKHFI 8036
V + + ++K R L ++ +S + + + D L + + + +
Sbjct: 1627 AVEDYAETVHQLSKTSRALVADSHPES-----ERISMRQSKVDKLYAGLKDLAEERRGKL 1681
Query: 8037 GQREE-FETAR--DSILVWLTEMDLQLTNIEHFSECDVQAKIKQ-LKAFQQEI-SLNHNK 8091
+R F+ R D + W+ E ++ + E + + +++ + F ++ ++ +
Sbjct: 1682 DERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQER 1741
Query: 8092 IEQIIAQGEQLIEKSEPLDAAIIEEELD------------------------ELRRY--- 8124
++ + ++LI DAA I E D EL ++
Sbjct: 1742 VDTVNHLADELINSGHS-DAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHD 1800
Query: 8125 CQEVFGRVERYHKKL 8139
+E+FGR++ HKKL
Sbjct: 1801 AKEIFGRIQDKHKKL 1815
Score = 124 bits (311), Expect = 4e-27
Identities = 311/1735 (17%), Positives = 655/1735 (37%), Gaps = 240/1735 (13%)
Query: 1444 DIKTMEMVKTKWDHFGSNFETLSVWITEKEKEL-NALETS-------SSAMDMQISQIKV 1495
D K++ + H+ S + L+V K L NA+ET S A D+ + I+
Sbjct: 249 DEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDL-LEWIEQ 307
Query: 1496 TIQEIESK--LSSIVGLEEEAQSFAQFVTTGESARIKAK--------------------- 1532
TI + ++ +S+VG++++ Q+F + T + + K
Sbjct: 308 TIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKV 367
Query: 1533 --------LTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAV 1584
++ I + E L + E + L +Q+K E+ R+ + + E L+
Sbjct: 368 YMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSE 427
Query: 1585 PIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRDSCVQEAAALQQQYE 1644
++ S + L + E++ + I A+ + VV + +E A + Y
Sbjct: 428 NQRLVSQDNFGFD-LPAVEAATKKHEAIETDIAAYEERVQAVV---AVARELEA--ENYH 481
Query: 1645 DILRRAKERQTA-------LENLLAHWQRLE---------KELSSFLTWLERGEAKASSP 1688
DI R + LE L A QRLE +E+ + W++ + S
Sbjct: 482 DIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQ 541
Query: 1689 E---------------------MDISADRVK-VEGELQLI------------QALQNEVV 1714
+ + I A+RV+ V Q Q +++ V
Sbjct: 542 DYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVA 601
Query: 1715 SQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDER-W-RDLPQIIN-----KRINFL 1767
Y +L QL ++ ++ K E +E W R+ +I++ K + +
Sbjct: 602 HMEFCYQELCQLAAER-RARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSV 660
Query: 1768 QSVVAEHQQFDELLLSFSVWIKLFLSELQTTSEISIMDHQVALTRHKDHAAEVESKKGEL 1827
++++H+ F++ + S + + E E I + + ++ + + L
Sbjct: 661 MRLLSKHRAFEDEMSGRSGHFEQAIKE----GEDMIAEEHFGSEKIRERIIYIREQWANL 716
Query: 1828 QSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLA--EFLQSHA 1885
+ L K L A LH Q A+D + ++V + + ++ H
Sbjct: 717 EQLSAIRKK--RLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHK 774
Query: 1886 SLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLK 1945
++ + R T++ ++++ S L ++ + + + G LS + K
Sbjct: 775 DVAEEIANYRPTLD---TLHEQASALPQE------------HAESPDVRGRLSGIEERYK 819
Query: 1946 IGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKAFQDQKEELLKSIEDIE 2005
+ R +A D L L SEADA + + D+KE+ L +++ E
Sbjct: 820 EVAELTRLRKQALQDTLA---------LYKMFSEADACEL----WIDEKEQWLNNMQIPE 866
Query: 2006 ERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDR 2065
+ D E +Q R F LE E+N+ + + A+Q+ E+
Sbjct: 867 KLEDLE--------VIQHR---FESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915
Query: 2066 EINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQ 2125
+ ++L W + L+ + + + + S + E I+
Sbjct: 916 QQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTK-------VIEST 968
Query: 2126 EDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKI---HSSDFSLVKTDMESTV 2182
+DL + + K+ ++DL +K L E +K+ H + + +
Sbjct: 969 QDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEIS 1028
Query: 2183 DKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHL-RAE 2241
D W ++ L+ N + S L D+ + W + +A ++ N L AE
Sbjct: 1029 DVWEEMKTTLK-NREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE--DMPNTLTEAE 1085
Query: 2242 ELLKEFESEVKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEV 2301
+LL + E+ +KN+ EE + K+ D+ E+ +T F+ L E+ ++
Sbjct: 1086 KLLTQHEN-IKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKM 1144
Query: 2302 AKGTLKDFTAQSTQVEKFINDIT---TWFTKVEESLMNCAQNETCE----ALKKVKDIQK 2354
+ ++ +QS ++F+ D + E L + T E A+KK +D
Sbjct: 1145 WENR-QNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMT 1203
Query: 2355 ELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESL 2414
+ + + I++ E L + + + + + +H + S+ L+++
Sbjct: 1204 TMDANEEKINAVVETGRRLVSD-GNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNR 1262
Query: 2415 E-KHFSESMQEFQEWFLGAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAV 2473
+ + F + QE W A++ S +++ L +K Q + ++ + LD +
Sbjct: 1263 DLQKFLQDCQELSLWINEKMLTAQDMS--YDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320
Query: 2474 TQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRK 2533
+EG L + + + ++E++T ++ ++ Q L D A++ F
Sbjct: 1321 EKEGMQLISE-KPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFD-ANKAELFTQSCAD 1378
Query: 2534 LNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSE 2593
L+ W+H +E + +++ G+ + + K +M ++ ++ +++L + Q LS+
Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSV---NILLKKQQMLENQMEVRKKEIEELQSQAQALSQ 1435
Query: 2594 EGHGAGQEGRLCSQLLTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDR 2653
EG + + T LL E+ + + + H+ ++ WV +R
Sbjct: 1436 EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQ-FNRDVEDEILWVG---ER 1491
Query: 2654 LACAESTLGSKD--TLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALRSSNKEGQRVIQ 2711
+ A ST + T++ + + Q + + +++ + + + S+ I+
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551
Query: 2712 TQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQP 2771
+L LK++W ++ + LE Y + + E WM +Q++ + +
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAA-EAEAWMS--EQELYMMSEEKA 1608
Query: 2772 GLKEKFVLLDHLQSILSEA-EDHTRALHRLIAKSRELYEKTEDESFK-DTAQEELKTQFN 2829
++ V + IL +A ED+ +H+L SR L + ES + Q ++ +
Sbjct: 1609 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1668
Query: 2830 DIMTVAKEKMRKVEEIVKDHLMYLD-AVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLS 2888
+ +A+E+ K++E + L L+ V + W+ + +E + ++ D
Sbjct: 1669 GLKDLAEERRGKLDE--RHRLFQLNREVDDLEQWI-AEREVVAGSHELGQDYEHVTMLQE 1725
Query: 2889 KIKELI-DSREIGASRLSRVESLAPEV-----------------KQNTTASGCELMHTEM 2930
+ +E D+ IG R+ V LA E+ A EL+ T
Sbjct: 1726 RFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRT 1785
Query: 2931 QALRADW--------------------KQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA 2970
Q L A + K+ + + + Q+ +E L E +
Sbjct: 1786 QILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGT 1845
Query: 2971 QLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED 3025
Q+ Q E + L +A + + + E++E W + +LDA + R D
Sbjct: 1846 QVRQLQEDAARLQAAYAGD-KADDIQKRENEVLEAW---KSLLDACESRRVRLVD 1896
Score = 121 bits (303), Expect = 3e-26
Identities = 321/1604 (20%), Positives = 611/1604 (38%), Gaps = 229/1604 (14%)
Query: 7092 LEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNN 7151
++A+ V+ + + D+ + E+ ++K+ S+ + LL E + T+ +N R
Sbjct: 267 MKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLL--------EWIEQTIIILNNR--- 315
Query: 7152 LLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDR---TNELLKAATNKDIADDEV 7208
+ A L + LQ + Y+ K T + + T + A N+ +
Sbjct: 316 ---KFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPRE 372
Query: 7209 ATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQA 7268
I D N + L + HE L+ ++ I+ ++L + A
Sbjct: 373 GKLISDINKAWERLEKAE------HERELALRNEL-------IRQEKLEQLARRFDRKAA 419
Query: 7269 LCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQ 7328
+ + S ++ + F L A+EA + E I +D++ +ER++ +
Sbjct: 420 MRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAI--------ETDIAAYEERVQAVV-- 469
Query: 7329 MLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQ 7388
++A +L+ N + + R N+ R W + R +L+ L +
Sbjct: 470 -----AVARELEAENYHDIK-----RITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 519
Query: 7389 TFLEKCET--WMEFLVQTEQKLAVEISGNYQHLLEQQ---RAHELFQAEMFSRQQILHSI 7443
F E WM+ E K+ V +HLL + + H L +A++ + + + +
Sbjct: 520 IFQEMLYIMDWMD-----EMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGV 574
Query: 7444 IIDGQRLLEQGQ---VDDRDEFNLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREM 7500
Q+ G+ D ++ + +Q + + A +RR ++ R W+ + EM
Sbjct: 575 NASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEM 634
Query: 7501 AEKLRKWLVEVSYLPMSG-----LGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVE 7555
AE+ W+ E + S L SV L + R DE+ + G + ++
Sbjct: 635 AEE-EGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRS-------GHFEQAIK 686
Query: 7556 AGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKL--AFLLKDWEKCEKGIAD 7613
G+ ++ G+E ++ + I+E+W + +KK+L A LL ++ AD
Sbjct: 687 EGEDMIAEEHFGSEK-IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQ----ADAD 741
Query: 7614 SLEKLRTFKKKLSQSLPDHHEELHAEQM--RCKELENAVGSWTDDLTQLSLLKDTL-SAY 7670
++ K+ S H+E + + + K++ + ++ L L L +
Sbjct: 742 DIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEH 801
Query: 7671 ISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNK------ELCEW 7724
+ D+ R+ ++ +++E+ LR+Q + + L + +FSE + E +W
Sbjct: 802 AESPDV---RGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQW 858
Query: 7725 LTQMESKVSQNGDILIEEMIEKLKKDYQEEIAIAQENKIQLQQMGERLAKASHESKASEI 7784
L M+ +I+ E L+ + + + + Q+ +L + H S+ EI
Sbjct: 859 LNNMQIPEKLEDLEVIQHRFESLEPEMNNQAS----RVAVVNQIARQLMHSGHPSE-KEI 913
Query: 7785 EYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYD 7844
+ + K+N RW +L+ + L L ++Q + ++W+ K V +
Sbjct: 914 KAQQDKLNTRWSQFRELVDRKKDALLSAL-SIQNYHLECNETKSWIRE------KTKVIE 966
Query: 7845 SCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRN 7904
S ++++ L LQR + TG+ L E L D A E + QA
Sbjct: 967 S--TQDLGNDLAGVMALQRKL----TGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1020
Query: 7905 LDRR------WRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSG 7958
L R W + R + E +L Q+FL D F+ WL ++ A
Sbjct: 1021 LSRLAEISDVWEEMKTTLKNREASLGEASKL-QQFLRDLDDFQSWLSRTQTAIASEDMPN 1079
Query: 7959 VIYTVAKEELKKFEAFQRQVHECLTQLELINKQYRRLARENRTDSACS-LKQMVHEGNQR 8017
+ T A++ L + E + ++ + + + + + +TD+ L+Q + +
Sbjct: 1080 TL-TEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYMFLRQRLQALDTG 1137
Query: 8018 WDNLQK------RVTSILRRLKHFIG---QREEFETARDSILVWLTEMDLQLTNIEHFSE 8068
W+ L K + S + F+ Q E F ++ +L TEM L E
Sbjct: 1138 WNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAH-TEMPTTLEGAE---- 1192
Query: 8069 CDVQAKIKQLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEV 8128
A IK+ + F + N KI ++ G +L+ +++ I+E++D +
Sbjct: 1193 ----AAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGN-INSDRIQEKVDSI------- 1240
Query: 8129 FGRVERYHKKLIRLPLPDDEHDLSDRELELEDSAALSDLHWHDRSADSLLSPQPSSNLSL 8188
DD H +RE E L D +R L Q LSL
Sbjct: 1241 -----------------DDRHR-KNRETASELLMRLKD----NRDLQKFL--QDCQELSL 1276
Query: 8189 SLAQPLRSERSGRDTPASVDSIPLEWDHDYDLSRDLESAMSR--ALPSEDEEGQDDKDFY 8246
+ + + + + D YD +R+L S + A +E ++ D
Sbjct: 1277 WINEKMLTAQ----------------DMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320
Query: 8247 LRGAVGLSDVMIPESPEAYVKLTENAIKNT-SGDHS---ALESQIRQLGKALDDSRFQIQ 8302
+ + L I E PE TE +K +G H LES + + L D+
Sbjct: 1321 EKEGMQL----ISEKPE-----TEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAEL 1371
Query: 8303 QTENIIR-SKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLEHKL---KEEEESLPGFVN 8358
T++ K G E Y K L + + + LE+++ K+E E L
Sbjct: 1372 FTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQ 1431
Query: 8359 LHSTETQTAGVIDRWELLQAQALSKEL-----RMKQNL---QKWQQFNSDLNSIWAWLGD 8410
S E ++ +D + L Q EL K NL ++ QFN D+ W+G
Sbjct: 1432 ALSQEGKSTDEVDS-KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVG- 1489
Query: 8411 TEEELEQLQRLELSTDIQTIELQIKKLKELQKAVD-HRKAIILSINLCSPEFTQADSKES 8469
E + + ++QT++L IKK + LQK + H+ I T + S +
Sbjct: 1490 --ERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSA 1547
Query: 8470 RDLQDRLSQMNGRWDRVCSLLEEWRGLLQDALMQCQGFHEMSHGLLLMLENIDRRKNEIV 8529
++ RL+ + W + E+ L++A Q + + + M E +E
Sbjct: 1548 EAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEK 1607
Query: 8530 PIDSNLDAEILQDHHKQLMQIKHELLESQLRVASLQDMSCQLLV---NAEGTDCLEAKEK 8586
D +L+ H QI + +E + + LV + E + K
Sbjct: 1608 AKDEQSAVSMLKKH-----QILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSK 1662
Query: 8587 VHVIGNRLKLLLKEVSRHIKELEKLLDVSSSQQDLSSWSSADEL 8630
V + LK L +E + E +L ++ DL W + E+
Sbjct: 1663 VDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREV 1706
Score = 116 bits (290), Expect = 1e-24
Identities = 371/1932 (19%), Positives = 735/1932 (38%), Gaps = 250/1932 (12%)
Query: 5866 LGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSP 5925
+ D+ ++WE L+ E++ L L RQ+K + + K E LSE+
Sbjct: 376 ISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR----- 430
Query: 5926 ESQMAEHQALMDEILMLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMST 5985
L+ QD + EA + A+++ + ER+
Sbjct: 431 --------------LVSQDNFG---------FDLPAVEAATKKHEAIETDIAAYEERVQA 467
Query: 5986 IRMKASGKRQLLEEKLND-QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKE 6044
+ A R+L E +D + R++ ++ + + L L + + L+ L K
Sbjct: 468 VVAVA---RELEAENYHDIKRITARKDNVIRLW----EYLLELLRARRQRLEMNLGLQKI 520
Query: 6045 PMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRL-KG 6103
+M +MD + E KV+ LS+ D + L G L K
Sbjct: 521 FQEM-LYIMDWMD-----EMKVLVLSQ-----------------DYGKHLLGVEDLLQKH 557
Query: 6104 SLLELQRALHDKQLNMQGTAQEKEESDVDLTATQSPGV-------QEWLAQARTTWTQQR 6156
+L+E + +++ + +K +D + P V E+ Q +R
Sbjct: 558 TLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAER 617
Query: 6157 QSSLQQQKELEQ---ELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQELGM 6213
++ L++ + L + E+AE++ +R E+IL S+ + D +LS+
Sbjct: 618 RARLEESRRLWKFFWEMAEEEGWIREK----EKIL---SSDDYGKDLTSVMRLLSKHRAF 670
Query: 6214 EGEKSSA----EDQMRMKWESLHQEFSTKQKLLQNVLE-QEQ----EQVLYSRPNRLLSG 6264
E E S E ++ + + +E +K+ + ++ +EQ EQ+ R RL
Sbjct: 671 EDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA 730
Query: 6265 VPLYKGDVPTQDKSA----VTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKLYDGVSATS 6320
L++ D A + ++ + +E S+QS K + + E Y
Sbjct: 731 SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPT---- 786
Query: 6321 TWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNR 6380
LD + E+ A+AL E E+ + I+E +E+ + L QA
Sbjct: 787 --LDTLHEQ---ASALPQEHAESPDVRGRL--SGIEERYKEVAELTRLRKQA-------- 831
Query: 6381 DVIEDTLGCLLGRLSLLDSVVNQRCHQ-MKERLQQILNFQNDLKVLFTSLADNKYIILQK 6439
++DTL L S D+ C + E+ Q + N Q K+ + +++ L+
Sbjct: 832 --LQDTLA-LYKMFSEADA-----CELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEP 883
Query: 6440 LANVFEQPVAEQIEAIQQ-AEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDE 6498
N A ++ + Q A + E+K + DKL +EL + D
Sbjct: 884 EMN----NQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL--VDRKKDA 937
Query: 6499 LMMIIGSRRSGLNQNLTL-----KSQYERALQDLADLLE---TGQEKMAGDQKIIVSSKE 6550
L+ + + L N T K++ + QDL + L Q K+ G ++ +V+ +
Sbjct: 938 LLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEA 997
Query: 6551 EIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRG 6610
++ L KE + H + + ++ + ++ + LK
Sbjct: 998 KLSDL---QKEAEKLESEHPDQAQAILSRLAEIS---------DVWEEMKTTLKNREASL 1045
Query: 6611 VELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNE 6670
E + + LD+ Q LSR + S L E + +T ++++K+ ++
Sbjct: 1046 GEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEK-----LLTQHENIKNEIDN 1100
Query: 6671 YQPKLYQVLDDGKRLLISISCSD---LESQLNQLGECWLSNTNKMSKELHRLETILKHWT 6727
Y+ ++ D G+ + + + L +L L W N++ K + +L
Sbjct: 1101 YEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGW----NELHKMWENRQNLLSQSH 1156
Query: 6728 RYQSESADLIHWLQSAKDRLEFWTQQSVTV-----PQELEMVRDHLNAFLEFSKEVDAQS 6782
YQ +L+ K F Q + P LE + +F +DA
Sbjct: 1157 AYQQ-------FLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANE 1209
Query: 6783 SLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQ--MDKLP 6840
++V+ TG +L+ +++ ++ ++ ID + N E L +L+ D
Sbjct: 1210 EKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRK---NRETASELLMRLKDNRDLQK 1266
Query: 6841 SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVN 6900
E+ WI+ E ++ + + + + +H K++ F ++ + +D +
Sbjct: 1267 FLQDCQELSLWIN--EKMLTAQDMSYDEA---RNLHSKWLKHQAFMAELASNKEWLDKIE 1321
Query: 6901 QSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNV 6960
+ +Q+ S+ E++ K E+L ++K W++L+ K Q L ++ + +
Sbjct: 1322 KEGMQLISEKPETEAVVK----EKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSC 1376
Query: 6961 QCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN 7020
L W E +++ D SV LK Q LE+ ++ ++KE+E+++ AL Q
Sbjct: 1377 ADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQE 1436
Query: 7021 KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYL-MEAR 7079
K S+ + + R QT ++ L ++L H+ D + L + R
Sbjct: 1437 GK---STDEVDSKRLTVQT--KFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGER 1491
Query: 7080 YSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSITNQLLKECHPPVTETLT 7139
L+ +L+ VQ+ + Q LQ +++ + + + ++ + E +
Sbjct: 1492 MPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIR 1551
Query: 7140 NTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAAT 7199
L ++ W L+EE ++ + + + Q Y D ++ A +Q+ L +
Sbjct: 1552 QRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQE-------LYMMS 1604
Query: 7200 NKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLS 7259
+ D++ A + + +L+ V+D +H+L + + V A S +S+++S+
Sbjct: 1605 EEKAKDEQSAVSMLKKHQILE--QAVEDYAETVHQLSKTSRALV---ADSHPESERISMR 1659
Query: 7260 QHLCALEQALCKQQTSLQAGVLDYE----TFAKSLEALEAWIVEAEEIL----QGQDPSH 7311
Q A K + G LD + ++ LE WI E E + GQD H
Sbjct: 1660 QSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEH 1719
Query: 7312 SSDLSTIQERMEELKGQMLKFSSMAPD-----LDRLNELGYRLPLNDKEIKRMQNLNRHW 7366
++ +QER E D D L G+ E K LN W
Sbjct: 1720 ---VTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWK--DGLNEAW 1774
Query: 7367 SLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQ-QRA 7425
+ + R L + H+ + + E + +Q + K E G Q+ +E QR
Sbjct: 1775 ADLLELIDTRTQILAASYELHKFYHDAKEIFGR--IQDKHKKLPEELGRDQNTVETLQRM 1832
Query: 7426 HELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR- 7484
H F+ ++ + + + D RL D D+ + + W+ ++ + RR
Sbjct: 1833 HTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRV 1892
Query: 7485 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7544
++D+ + R+ M L W+ +V + P + L + Q +
Sbjct: 1893 RLVDTGDK--FRFFSMVRDLMLWMEDV--IRQIEAQEKPRDVSSVELLMNNHQGIKAEID 1948
Query: 7545 RQQGSYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDW 7604
+ S+ +E GK LL +E ++ +L ++ EK K + E++ + L +L+
Sbjct: 1949 ARNDSFTTCIELGKSLLARKHYASE-EIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVH 2007
Query: 7605 EKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAVGSWTDDLTQLSLLK 7664
+ L S+ + +E+ R + E + +W + + L L
Sbjct: 2008 QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLT 2067
Query: 7665 DTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEW 7724
E +E+ ++Q EE R++ SE+ + +W
Sbjct: 2068 TL--------------ELLEVRRQQEEE-------ERKRRPPSPEPSTKVSEEAESQQQW 2106
Query: 7725 LTQMESKVSQNG 7736
T +VSQNG
Sbjct: 2107 DTSKGEQVSQNG 2118
Score = 112 bits (279), Expect = 2e-23
Identities = 323/1717 (18%), Positives = 664/1717 (38%), Gaps = 220/1717 (12%)
Query: 6401 VNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYII-----LQKLANVFEQPVAEQIEAI 6455
+N ++ + + I+++ +++KVL S K+++ LQK V E + Q E +
Sbjct: 513 MNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLV-EADIGIQAERV 571
Query: 6456 QQAEDGLKEFDAGIIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLT 6515
+ ++F G K Q ++ ++ Y EL + RR+ L ++
Sbjct: 572 RGVNASAQKFATD-----GEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRR 626
Query: 6516 LKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEY---FQGLESHM-- 6570
L + ++ + E + + D ++S + +LL KH+ + G H
Sbjct: 627 LWKFFWEMAEEEGWIREKEKILSSDDYGKDLTS---VMRLLSKHRAFEDEMSGRSGHFEQ 683
Query: 6571 -------ILTETLF--RKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWS 6621
++ E F KI + Q+ + Q SA+ K KR E + + +
Sbjct: 684 AIKEGEDMIAEEHFGSEKIRERIIYIREQWAN--LEQLSAIRK---KRLEEASLLHQFQA 738
Query: 6622 HLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITLYQHLKSSLNEYQPKLYQVLDD 6681
D+ + L++V SS VG E + L+ + ++ + + Y+P L + +
Sbjct: 739 DADDIDAWMLDILKIVSSS--DVGHDEYSTQSLVKK---HKDVAEEIANYRPTLDTLHEQ 793
Query: 6682 GKRLLISISCS-DLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWL 6740
L + S D+ +L+ + E + K EL RL + + ++ +
Sbjct: 794 ASALPQEHAESPDVRGRLSGIEERY-----KEVAELTRLR-------KQALQDTLALYKM 841
Query: 6741 QSAKDRLEFWTQQ------SVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6794
S D E W + ++ +P++LE + + F E++ Q+S + V Q
Sbjct: 842 FSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ 901
Query: 6795 LLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHA-ISEVMSWIS 6853
L+ ++++ +++++W+ + ++ L L + + H +E SWI
Sbjct: 902 LMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSALSIQNYHLECNETKSWIR 959
Query: 6854 LMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVES 6913
VI+ +D + G A+ L + + I K S LQ ++ +ES
Sbjct: 960 EKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKL--------SDLQKEAEKLES 1011
Query: 6914 KRSDKTD-FAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEK 6972
+ D+ +L ++ W+ ++ + + L G ++ ++ ++W +
Sbjct: 1012 EHPDQAQAILSRLAEISDVWEEMKTTLKNREASL-GEASKLQQFLRDLDDFQSWLSRTQT 1070
Query: 6973 RLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNKKEDVSSIVMST 7032
+ + + L +++++ I E++ +K+ G + Q + + +
Sbjct: 1071 AIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQR 1130
Query: 7033 LRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRL---LT 7089
L+ L W L H + + + L S + + ++L Y L+ + L
Sbjct: 1131 LQALDTGWNEL-HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLE 1189
Query: 7090 GSLEAVQVQVDNLQNLQDDLEKQE------RSLQKFGSITNQLLKEC-------HPPVTE 7136
G+ A++ Q D + + + EK R L G+I + ++E H E
Sbjct: 1190 GAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRE 1249
Query: 7137 TLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL-- 7194
T + L + ++ N L++ + Q L LW K + Q S + + + L
Sbjct: 1250 TASELL--MRLKDNRDLQKFLQDCQE----LSLWINEKMLTAQDMSYDEARNLHSKWLKH 1303
Query: 7195 ----LKAATNKDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASA 7250
+ A+NK+ D +Q ++ + VK+ L LH++ E L+ A
Sbjct: 1304 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1363
Query: 7251 IQSDQLSLSQHLCA-LEQALCKQQTSLQAGVLDYETFAKSLEALEAWIVEAEEILQGQDP 7309
+++ L CA L++ L ++ +Q+ + + K L ++ +++ +++L+ Q
Sbjct: 1364 FDANKAELFTQSCADLDKWLHGLESQIQS-----DDYGKDLTSVNI-LLKKQQMLENQ-- 1415
Query: 7310 SHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN-RHWSL 7368
+ ++ +EEL+ Q S D ++ RL + K ++ ++ LN R +L
Sbjct: 1416 -----MEVRKKEIEELQSQAQALSQEGKSTDEVDSK--RLTVQTKFMELLEPLNERKHNL 1468
Query: 7369 ISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQ----R 7424
++S+ +F++ +E W+ +++ + S ++ H L+ +
Sbjct: 1469 LASKEIHQFNR----------DVEDEILWVG------ERMPLATSTDHGHNLQTVQLLIK 1512
Query: 7425 AHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQRR 7484
++ Q E+ Q + I Q ++ + +L L W +I ++R
Sbjct: 1513 KNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH 1572
Query: 7485 GIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFL 7544
++ R Q Y + AE W+ E MS ++A+ V +K +
Sbjct: 1573 RRLEEAHRAQQYYFDAAEA-EAWMSEQELYMMSE--------EKAKDEQSAVSMLKKHQI 1623
Query: 7545 RQQG--SYILTVEAGKQLLLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLK 7602
+Q Y TV LS S +A +A+ + + SMR + + KL LK
Sbjct: 1624 LEQAVEDYAETVHQ-----LSKTS------RALVADSHPESERISMR-QSKVDKLYAGLK 1671
Query: 7603 DWEKCEKGIADSLEKLRTFKKKL---------------SQSLPDHHEELHAEQMRCKELE 7647
D + +G D +L +++ S L +E + Q R +E
Sbjct: 1672 DLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFA 1731
Query: 7648 NAVGSWTDD-LTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGE 7706
G+ + + ++ L D L D + + E + L W +L + R Q +
Sbjct: 1732 RDTGNIGQERVDTVNHLADEL-INSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAA 1790
Query: 7707 RLNEWAVFSEKNKELCEWLTQMESKVSQN--GDILIEEMIEKLKKDYQEEIAIAQENKIQ 7764
E F KE+ + K+ + D E ++++ ++ +I Q
Sbjct: 1791 SY-ELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQ 1849
Query: 7765 LQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMS 7824
LQ+ RL A KA +I+ + +V + W+ LLD +R +L +T + +
Sbjct: 1850 LQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSM-VR 1908
Query: 7825 SLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLH 7884
L W+ + ++ +S E+ +N Q ++ +I+ + + + L + LL
Sbjct: 1909 DLMLWMEDVIRQIEAQEKPRDVSSVEL--LMNNHQGIKAEIDARNDSFTTCIELGKSLL- 1965
Query: 7885 DCDACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEETWRLW-------QKFLDDY 7937
A+ + + + E K E+ W W +F D
Sbjct: 1966 -----------ARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WLRLILEVHQFSRDA 2013
Query: 7938 SRFEDWLKSSERTAAFPSSSGVIYTVAKEE--LKKFEAFQRQVH---------ECLTQLE 7986
S E WL E + SS + +V + E +K+ EAF++ E LT LE
Sbjct: 2014 SVAEAWLLGQE---PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2070
Query: 7987 L--INKQYRRLARENRTDSACSLKQMVH--EGNQRWD 8019
L + +Q R+ R S ++ E Q+WD
Sbjct: 2071 LLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWD 2107
Score = 111 bits (278), Expect = 3e-23
Identities = 293/1625 (18%), Positives = 637/1625 (39%), Gaps = 190/1625 (11%)
Query: 2974 QALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEIL---DALQKAEPRTEDLKSQL 3030
Q LE L K + + L +++ + + +V G+ +L D LQK D+ Q
Sbjct: 509 QRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQA 568
Query: 3031 NELC-------RFSRDLSTYSGKVSGLIKE--------YNCLC-LQASKGCQNKEQILQQ 3074
+ +F+ D Y +I++ Y LC L A + + +E
Sbjct: 569 ERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLW 628
Query: 3075 RFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSK 3134
+F + + W + K D ++++ V L K + F E + +
Sbjct: 629 KFFWEMAEEEGW-IREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKE 687
Query: 3135 GELLSTLLTKEK--AKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPI 3192
GE ++ +E ++ I+ ++ +E W N ++ LE + + F+ A+ I
Sbjct: 688 GE---DMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASL-LHQFQADADDI 743
Query: 3193 QDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQLWEGQA 3252
W+ K+V SS+ +D + + +K + V EEI Y P L+ L E+A L + A
Sbjct: 744 DAWMLDILKIV-SSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHA 802
Query: 3253 ASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFS------LGIKELQDWMTDA 3306
S R R+S + +Y ++ LT+ + L +A + FS L I E + W+ +
Sbjct: 803 ESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNM 862
Query: 3307 IHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTI 3366
D V+ R LE ++ + + + I + L ++ I
Sbjct: 863 -----QIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ----LMHSGHPSEKEI 913
Query: 3367 QQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQH 3426
+ Q + W+ R K L ALS +Y + W+ + ++
Sbjct: 914 KAQQDKLNTRWSQFRELVDRKKDALLSALS-IQNYHLECNETKSWIREKTKVIESTQDLG 972
Query: 3427 AELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQ--------LELQDLQE 3478
+L + K + ++++ + L ++ + + + Q E+ D+ E
Sbjct: 973 NDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWE 1032
Query: 3479 RYRAIQERAKEAVTKSEKLVRLHQEYQRDLKAFEVWLGQEQ----------------EKL 3522
+ + + ++ ++ KL Q++ RDL F+ WL + Q + L
Sbjct: 1033 EMKTTLKNREASLGEASKL----QQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLL 1088
Query: 3523 DQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESL 3582
Q+ ++ + +E + ++++ +GQ + R+ + QA D L
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDA-QYMFLRQRL------QALDTGWNEL 1141
Query: 3583 RQDWQAYQHRLSETRT--QFNNVVNKLR--LMEQKFQQVDEWLKTAEE------KKWHEE 3632
+ W+ Q+ LS++ QF + L Q++ + T E KK +
Sbjct: 1142 HKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDF 1201
Query: 3633 VT---AYRDEVEEVGARAQEILDESHVNS-RMGCQATQLTSRYQ------ALLLQVLEQI 3682
+T A +++ V + ++ + ++NS R+ + + R++ + LL L+
Sbjct: 1202 MTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDN 1261
Query: 3683 KFLEEEIQSLEE-----SESSLSS-----------YSDWYGSTHKNF-------KNVATK 3719
+ L++ +Q +E +E L++ +S W H+ F K K
Sbjct: 1262 RDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWL--KHQAFMAELASNKEWLDK 1319
Query: 3720 IDKVDTVMMGKKLKTLEVL---LKDMEKGHSLLKSAREKGERAVKYLEEGEAE------- 3769
I+K ++ +K +T V+ L + K +L+S + +A + + +AE
Sbjct: 1320 IEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQ--TKAQRLFDANKAELFTQSCA 1377
Query: 3770 RLRKEIHDHMEQL------KELTST--VRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQ 3821
L K +H Q+ K+LTS + K+ LE + + K+ ++ ++ Q +++
Sbjct: 1378 DLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEG 1437
Query: 3822 EILHVPEEPKMELYEKKAQ-LSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKDK 3880
+ + ++ + K + L + +L+ + + R+ + +L + + + L
Sbjct: 1438 KSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATS 1497
Query: 3881 ID---QLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHA 3937
D LQ+ Q L + + +EI G + R++++ + ++ + ++Q
Sbjct: 1498 TDHGHNLQT-VQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ---- 1552
Query: 3938 HLQGTKDSYSAICSTAQRMYQSLE--HELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPP 3995
L K + + ++ ++ LE H Q++ + +AW+S Q S +
Sbjct: 1553 RLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYF---DAAEAEAWMSE-QELYMMSEEKA 1608
Query: 3996 LSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTT---AKDIQQTEQTIEQKLV 4052
A+ +K + L++ Y + + + S A V + ++ I + +++
Sbjct: 1609 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1668
Query: 4053 QAQNLTQ---GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVK 4109
++L + G + +H +L + D +Q + + EL V+ +++ +
Sbjct: 1669 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR 1728
Query: 4110 KLQSKQASV-NTIIEKVNKLTKKEESPEHKEI-------NHLNDQWLDLCRQSNNLCLQR 4161
+ ++ ++ VN L + + H + + LN+ W DL +
Sbjct: 1729 EFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQIL 1788
Query: 4162 EEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAI 4221
+ + YHD + +K + L R +E L+++ + A+
Sbjct: 1789 AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNT-----VETLQRMHTTFEHDIQAL 1843
Query: 4222 EDLKDQKQKMIEHLNL----DDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNV 4277
Q Q+ L D + ++++ + + + W L D + + +V + + +
Sbjct: 1844 GTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR-RVRLVDTGDKFR 1902
Query: 4278 VQSRFQELMEWAEEQQPNIAEALKQSPPPDMA--QNLLMDHLAICSELEAKQMLLKSLIK 4335
S ++LM W E+ I + Q P D++ + L+ +H I +E++A+ + I+
Sbjct: 1903 FFSMVRDLMLWMEDV---IRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIE 1959
Query: 4336 DADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQAT 4395
++A ++ +K L + + D R ++L + + E QF A
Sbjct: 1960 LGKSLLARKHYASEEIKEKLLQLTEKRKEMI-DKWEDRWEWL-RLILEVHQFSRDASVAE 2017
Query: 4396 SQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTE 4455
+ + E + RE I D+V K +K ++ + S T+ + L + EV
Sbjct: 2018 AWLLGQEPYLSSRE-IGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRR 2076
Query: 4456 QEKSE 4460
Q++ E
Sbjct: 2077 QQEEE 2081
Score = 98.6 bits (244), Expect = 2e-19
Identities = 254/1419 (17%), Positives = 565/1419 (39%), Gaps = 160/1419 (11%)
Query: 3161 WKNFHSNLHQKESALENLKIQMKDFEVSAEPI-------QDWLSKTEKMVHESSNRLYDL 3213
W+ H++E AL N I+ + E A + WLS+ +++V + N +DL
Sbjct: 383 WERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQD-NFGFDL 441
Query: 3214 PAKRREQQKLQSVLEEIHCYEPQLNRLKEKAQQL-WEGQAASKSFRHRVSQLSSQYLALS 3272
PA +K +++ +I YE ++ + A++L E K R + + L
Sbjct: 442 PAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLL 501
Query: 3273 NLTKEKVSRLDRIVAEHNQFS--LGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKL 3330
L + + RL+ + F L I + D M + D H + +L TL +
Sbjct: 502 ELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTL-V 560
Query: 3331 EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQ 3390
EA + ++ E+ + + + + P I+ ++ ++ + L +++
Sbjct: 561 EADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRAR 620
Query: 3391 LEGALSKWTSYQDGVRQFSGWMDSMEANLNESERQHAELRDKTTMLGKAKLLNEEVLSYS 3450
LE + W + + + + GW+ E L+ S+ +L +L K + +E+ S
Sbjct: 621 LEESRRLWKFFWE-MAEEEGWIREKEKILS-SDDYGKDLTSVMRLLSKHRAFEDEMSGRS 678
Query: 3451 SLLETIEVKGAGM--TEHYVTQL---ELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQ 3505
E +G M EH+ ++ + ++E++ +++ + + E+ LHQ +Q
Sbjct: 679 GHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ-FQ 737
Query: 3506 RDLKAFEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTRED 3565
D + W+ + K+ S + D ++ ++ ++ +++ A + L++ LH +
Sbjct: 738 ADADDIDAWM-LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDT-LHEQAS 795
Query: 3566 VIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAE 3625
+P ++ D + RLS ++ V RL +Q Q K
Sbjct: 796 ALPQEHAESPD------------VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS 843
Query: 3626 E----KKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQ 3681
E + W +E + + ++ +++ D + R ++ + QA + V+ Q
Sbjct: 844 EADACELWIDEKEQWLNNMQ----IPEKLEDLEVIQHRFESLEPEMNN--QASRVAVVNQ 897
Query: 3682 IKFLEEEIQSLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKD 3741
I + + S SE + + D + F+ + + K D ++ ++ + +
Sbjct: 898 I--ARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR--KKDALLSALSIQNYHLECNE 953
Query: 3742 ----MEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEHMTLE 3797
+ + +++S ++ G + +R + + ++ S ++KE LE
Sbjct: 954 TKSWIREKTKVIESTQDLGNDLAGVM---ALQRKLTGMERDLVAIEAKLSDLQKEAEKLE 1010
Query: 3798 KGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTV------ 3851
E D+ +A+ +AE ++ EE K L ++A L + LQQ +
Sbjct: 1011 ------SEHPDQAQAILSRLAEISDVW---EEMKTTLKNREASLGEASKLQQFLRDLDDF 1061
Query: 3852 ---LSHEPSVKSVREKGEALLE----LVQDVTLKDKIDQLQSDYQDLCSIGKAMME---- 3900
LS + + + L E L Q +K++ID + DYQ + +G+ + +
Sbjct: 1062 QSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTD 1121
Query: 3901 -EIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQS 3959
+ RL L G + + ++ Q L Q+ HA+ Q +D+ A+ +
Sbjct: 1122 AQYMFLRQRLQALD-TGWNELHKMWENRQNLLSQS-HAYQQFLRDT-----KQAEAFLNN 1174
Query: 3960 LEHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVK---------HFRA 4010
E+ L H TL+ +A + Q D + + A+ + +
Sbjct: 1175 QEYVL-AHTEMPTTLEGAEAAIKK-QEDFMTTMDANEEKINAVVETGRRLVSDGNINSDR 1232
Query: 4011 LQEQA-----------RTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQ 4059
+QE+ T +LL + D N ++ +D Q+ I +K++ AQ+++
Sbjct: 1233 IQEKVDSIDDRHRKNRETASELLMRLKD--NRDLQKFLQDCQELSLWINEKMLTAQDMS- 1289
Query: 4060 GWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVN 4119
++E ++L S+ W+ +H +A N K+++ K++ + +
Sbjct: 1290 -YDEARNLHSK-WL--------------KHQAFMAELASN-----KEWLDKIEKE--GMQ 1326
Query: 4120 TIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVE 4179
I EK + E+ +++ L+ W ++ + QR D + + ++
Sbjct: 1327 LISEK-----PETEAVVKEKLTGLHKMW-EVLESTTQTKAQRLFDANKAELFTQSCADLD 1380
Query: 4180 VFLEKFTT--EWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQKMIEH--- 4234
+L + + D+ + D S + L+ + L ++ RK IE+L+ Q Q + +
Sbjct: 1381 KWLHGLESQIQSDDYGK-DLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKS 1439
Query: 4235 LNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQP 4294
+ D + + QT +E LE L +RK + + +E++ ++ + W E+ P
Sbjct: 1440 TDEVDSKRLTVQTKFME----LLEPLNERKHNLLAS--KEIHQFNRDVEDEILWVGERMP 1493
Query: 4295 NIAEALKQSPPPDMAQNLLMDHLAICSELEAKQMLLKSLIKDADRVMADLGLNERQVIQK 4354
+A + Q L+ + + E++ Q + + + + ++ D + I++
Sbjct: 1494 -LATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQ 1552
Query: 4355 ALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLL 4414
L+D + L + +R + L +A Q+ +A + + + E +M E
Sbjct: 1553 RLADLKQLWGLLIEETEKRHRRLEEA-HRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDE 1611
Query: 4415 PDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDS 4474
VS +K + + +++ Y V L R L+ + + E + + ++ +Y
Sbjct: 1612 QSAVS-MLKKHQILEQAVEDYAETVHQLSKTSRALVAD-SHPESERISMRQSKVDKLYAG 1669
Query: 4475 VLQKCSHRLQELEKNLVSRKHFKEDFDKACHWLKQADIV 4513
+ R +L++ + D W+ + ++V
Sbjct: 1670 LKDLAEERRGKLDER-HRLFQLNREVDDLEQWIAEREVV 1707
Score = 95.1 bits (235), Expect = 3e-18
Identities = 249/1456 (17%), Positives = 575/1456 (39%), Gaps = 166/1456 (11%)
Query: 1265 QAEKILDTEN----LFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDR--GH 1318
+ EKIL +++ L +LL H+ +S + +Q I ++GE + + G
Sbjct: 643 EKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAI---KEGEDMIAEEHFGS 699
Query: 1319 EELRK----LESTLDGLERSRERQERRIQVTLRKWERFETNKETV-------VRYLFQTG 1367
E++R+ + LE+ +++R++ +F+ + + + ++ + +
Sbjct: 700 EKIRERIIYIREQWANLEQLSAIRKKRLEEA-SLLHQFQADADDIDAWMLDILKIVSSSD 758
Query: 1368 SSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQA 1427
H+ + + S ++ E+ + +++ QA L +E +E P ++++
Sbjct: 759 VGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERY 818
Query: 1428 KSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMD 1487
K + E + + L++ + +M S + +WI EKE+ LN ++ D
Sbjct: 819 KEVAELTRLRKQALQDTLALYKMF--------SEADACELWIDEKEQWLNNMQIPEKLED 870
Query: 1488 MQISQIKVTIQEIE--SKLSSIVGLEEEAQSFAQFVTTGESARIKAKLTQIRRYGEELRE 1545
+++ Q + E E ++ S + + + A+ E IKA+ ++ + RE
Sbjct: 871 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEK-EIKAQQDKLNTRWSQFRE 929
Query: 1546 HAQCLEGTILGHLSQQQKFEE--------------------------NLRKIQQSVSEFE 1579
+ +L LS Q E + +Q+ ++ E
Sbjct: 930 LVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGME 989
Query: 1580 -DKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAIT-AFSASARKVVNRDSCVQEAA 1637
D +A+ K+ E K+ EH D QA+ S + I+ + + NR++ + EA+
Sbjct: 990 RDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEAS 1049
Query: 1638 ALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRV 1697
LQQ D L F +WL R + +S +M +
Sbjct: 1050 KLQQFLRD-------------------------LDDFQSWLSRTQTAIASEDMPNTL--T 1082
Query: 1698 KVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLP 1757
+ E L + ++NE+ + Y K+ + E + + ++ L+ LD W +L
Sbjct: 1083 EAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH 1142
Query: 1758 QIINKRINFLQSVVAEHQQF------DELLLSFSVWIKLFLSELQTTSEISIMDHQVALT 1811
++ R N L A +QQF E L+ ++ L +E+ TT E + A+
Sbjct: 1143 KMWENRQNLLSQSHA-YQQFLRDTKQAEAFLNNQEYV-LAHTEMPTTLE----GAEAAIK 1196
Query: 1812 RHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQ--GKAEDCFQLFEEASQVVER 1869
+ +D +++ + ++ ++ +L S G + + +D + E + +
Sbjct: 1197 KQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLM 1256
Query: 1870 RQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESA 1929
R L +FLQ LS + + T + M+ +E+ ++L+ +A +
Sbjct: 1257 RLKDNRDLQKFLQDCQELSLWINEKMLTAQ---DMSYDEA----RNLHSKWLKHQAFMAE 1309
Query: 1930 AVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEADALAVLKKA 1989
S L K + SE+ + ++L G + + L T Q++A L KA
Sbjct: 1310 LASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA 1369
Query: 1990 --FQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKD 2047
F +L K + +E + + + ++ L+ LE+++ + E+ L+
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDL-TSVNILLKKQQMLENQMEVRKKEIEELQS 1428
Query: 2048 KAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSK 2107
+A+ ++Q+ + EVD + ++ + + ++E + ++ + ++++ +
Sbjct: 1429 QAQALSQEGKS-TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILW 1487
Query: 2108 VLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLLSELKKIH 2167
V E T + + ++ K++T + ++ Q +D+ + ++++++ +
Sbjct: 1488 VGERMPLATSTDHG-HNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLS 1546
Query: 2168 SSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQM 2227
+ D++ ++ +EK ++ + + D E E W
Sbjct: 1547 AEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAA----EAEAW-------- 1594
Query: 2228 AENISNLDNHLRAEELLKEFESEV----KNKALR--LEELHSKVNDLKELTKNL--ETPP 2279
+S + ++ +EE K+ +S V K++ L +E+ V+ L + ++ L ++ P
Sbjct: 1595 ---MSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHP 1651
Query: 2280 DLQFI---EADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMN 2336
+ + I ++ + + K++ E +G L D + Q+ + ++D+ W + E +
Sbjct: 1652 ESERISMRQSKVDKLYAGLKDLAEERRGKL-DERHRLFQLNREVDDLEQWIAEREVVAGS 1710
Query: 2337 CAQNETCEALKKVKDIQKELQSQQSNISSTQ-ENLNSLCRKYHS---AELESLGRAMTGL 2392
+ E + +++ +E NI + + +N L + + ++ ++ GL
Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1770
Query: 2393 IKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFLGAKAAAKESSDRTG-DSKVLEA 2451
+ + +L L S E H + + +E F + K+ + G D +E
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELH--KFYHDAKEIFGRIQDKHKKLPEELGRDQNTVET 1828
Query: 2452 KLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCL 2511
+ +++ + ++ L A + IQ++ + E +++ L C
Sbjct: 1829 LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACE 1888
Query: 2512 KDKQALQDCASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFL 2571
+ L D + F R L LW+ ++ + + EK +V VE+ +
Sbjct: 1889 SRRVRLVDTGDKF-RFFSMVRDLMLWMEDVIRQIEAQ----------EKPRDVSSVELLM 1937
Query: 2572 -------GELLAARESLDKLSQRGQLLSEEGHGAGQE-GRLCSQLLTSHQNLLRMTKEKL 2623
E+ A +S + G+ L H A +E QL + ++ +++
Sbjct: 1938 NNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRW 1997
Query: 2624 RSCQVALQEHEALEEA 2639
++ L+ H+ +A
Sbjct: 1998 EWLRLILEVHQFSRDA 2013
Score = 93.6 bits (231), Expect = 8e-18
Identities = 235/1268 (18%), Positives = 513/1268 (40%), Gaps = 131/1268 (10%)
Query: 4098 QNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKE-ESPEHK-EINHLNDQWLDLCRQSN 4155
Q++V + KD +++ + + +++T+ E+ + L ++ ESP+ + ++ + +++ ++
Sbjct: 767 QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAE--- 823
Query: 4156 NLCLQREEDLQRTRDYHDCMN---VVEVFLEKFTTEWDNLAR-----SDAESTAVHLEAL 4207
L R++ LQ T + + E+++++ +W N + D E E+L
Sbjct: 824 -LTRLRKQALQDTLALYKMFSEADACELWIDE-KEQWLNNMQIPEKLEDLEVIQHRFESL 881
Query: 4208 KKLALALQERKYAIEDLKDQKQKMIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQV 4267
+ + Q + A+ + Q + + H ++ +K Q L RW Q +L+ RK
Sbjct: 882 EP-EMNNQASRVAVVN---QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDA 937
Query: 4268 SVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAICSE--LEA 4325
++ L N E W E+ I Q D+A + + E L A
Sbjct: 938 LLSALSIQNY-HLECNETKSWIREKTKVIEST--QDLGNDLAGVMALQRKLTGMERDLVA 994
Query: 4326 KQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKT 4385
+ L L K+A+++ ++ ++ Q I L++ + + R L +A S+
Sbjct: 995 IEAKLSDLQKEAEKLESEHP-DQAQAILSRLAEISDVWEEMKTTLKNREASLGEA-SKLQ 1052
Query: 4386 QFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQ 4445
QFL + S + + + I + L + K + ++ + + Y+ + +
Sbjct: 1053 QFLRDLDDFQSWLSRTQTAIASEDMPNTLTE-AEKLLTQHENIKNEIDNYEEDYQKMRDM 1111
Query: 4446 GRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKH----FKEDFD 4501
G + + T+ + + +LQ L + ++ + H++ E +NL+S+ H F D
Sbjct: 1112 GEMVTQGQTDAQYMFLRQRLQALDTGWNEL-----HKMWENRQNLLSQSHAYQQFLRDTK 1166
Query: 4502 KACHWLKQAD-IVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILP 4560
+A +L + ++ E+ E +E + K ++ + E + + TG+ ++
Sbjct: 1167 QAEAFLNNQEYVLAHTEMPTTLEGAE--AAIKKQEDFMTTMDANEEKINAVVETGRRLVS 1224
Query: 4561 SLNEVDHSYLSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELE 4620
N ++ + EK++++ + K + +L R + ++ Q EL
Sbjct: 1225 DGN-INSDRIQEKVDSIDDRHR--------KNRETASELLMRLKDNRDLQKFLQDCQELS 1275
Query: 4621 AQFLRMSKVPTDLAVEEALSLQDGC---RAILDEVAGLGEAVDELNQKKEGFRSTGQPWQ 4677
D++ +EA +L +A + E+A E +D++ +KEG + + +
Sbjct: 1276 LWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI--EKEGMQLISEKPE 1333
Query: 4678 PD-----KMLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEE--Q 4730
+ K+ L ++ L+ T+ + L D A + + C L++ L ++ +
Sbjct: 1334 TEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKA-ELFTQSCADLDKWLHGLESQIQS 1392
Query: 4731 SKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLDPLAYE-KARHQIQS 4789
++ LK L ++ V K+ +E+L L+ E K+ ++ S
Sbjct: 1393 DDYGKDLTSVNILLKKQQMLENQME----VRKK---EIEELQSQAQALSQEGKSTDEVDS 1445
Query: 4790 WQGELKLLTSAIGETVTECESRMVQSID---FQTEMSRSLDWLRRVKAELSGPVYLDLNL 4846
+ ++ + E + E + ++ S + F ++ + W+ + L+ NL
Sbjct: 1446 KRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGE-RMPLATSTDHGHNL 1504
Query: 4847 QDIQEEIRKIQIHQEEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDI 4906
Q +Q I+K Q Q+E+Q ++ + + + T + L + + LA+L +L G +
Sbjct: 1505 QTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLL 1564
Query: 4907 QEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHME 4966
E R L E + + Q+YY A W+ + + + D +SA LK H
Sbjct: 1565 IEETEKRHRRLEEAH-RAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQ- 1622
Query: 4967 FFSTEDQFHSNLEELHSLVATLDPLIKPTGKED-----LEQKVASLELRSQRMSRDSGAQ 5021
E E +H L T L+ + E + KV L + ++ + +
Sbjct: 1623 --ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGK 1680
Query: 5022 VDLLQRCTAQWHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALV--- 5078
+D R +Q RE ++D E+ ++E ++ + SHE + EH ++
Sbjct: 1681 LDERHRL------FQLNRE-----VDDLEQWIAEREVV--AGSHELGQDY-EHVTMLQER 1726
Query: 5079 ------SVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQE 5132
N E++ + A +L +G+ + AT++ + + W L + +
Sbjct: 1727 FREFARDTGNIGQERVDTVNHLADELINSGH-SDAATIAEWKDGLNEAWADLLELIDTRT 1785
Query: 5133 KILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQ 5192
+IL A E F + K+ I KLP + E TL H TF +++
Sbjct: 1786 QILA-ASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVE--TLQRMHTTFEHDIQA 1842
Query: 5193 QQSALGMLRQQTLSMLQ-----DGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLV 5247
+ + L Q+ + LQ D A E +++ ++ D C + + ++ G
Sbjct: 1843 LGTQVRQL-QEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTG--- 1898
Query: 5248 KQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTE-ATNHRQNIEKM 5306
D+ + + + W+++ +I+AQ + + E N+ Q I+
Sbjct: 1899 -----DKFRFFSMVRDLMLWMEDVIR-------QIEAQEKPRDVSSVELLMNNHQGIKAE 1946
Query: 5307 AEEQKEKY 5314
+ + + +
Sbjct: 1947 IDARNDSF 1954
Score = 89.0 bits (219), Expect = 2e-16
Identities = 328/1871 (17%), Positives = 701/1871 (37%), Gaps = 223/1871 (11%)
Query: 4863 VQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYS 4922
+QS +R N +K + +LIS D+ + L + + + + ALR ++
Sbjct: 356 IQSKMRANN-----QKVYMPREGKLIS-DINKAWERLEKAEHERELALRNELIRQEKLEQ 409
Query: 4923 QCQRYYQVFQAANDWLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELH 4982
+R+ + WL + Q L+ G D+ + E K H + + ++ +
Sbjct: 410 LARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVV 469
Query: 4983 SLVATLD-----PLIKPTGKED-----LEQKVASLELRSQRMSRDSGAQVDLLQRC-TAQ 5031
++ L+ + + T ++D E + L R QR+ + G Q +
Sbjct: 470 AVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMD 529
Query: 5032 WHDYQKAREEVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVAL 5091
W D K V+ L D K L E+ L +H + + + E++ +
Sbjct: 530 WMDEMK----VLVLSQDYGKHLL-----------GVEDLLQKHTLVEADIGIQAERVRGV 574
Query: 5092 EEKASQLEKTG---NDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNK 5148
A + G + + + + L +A ++ LE++ W F
Sbjct: 575 NASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEM 634
Query: 5149 VKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSML 5208
++ E + ++K+ S ++ LL H F E + S +Q +
Sbjct: 635 AEE--EGWIREKEKILSSDDYGKDLTSVMRLLSKHRAF----EDEMSGRSGHFEQAIKEG 688
Query: 5209 QDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWV 5268
+D A + + I ++++ N+ E++ K +E + + + W+
Sbjct: 689 EDMIAEEHFGSEKIRERIIYIREQWANL-EQLSAIRKKRLEEASLLHQFQADADDIDAWM 747
Query: 5269 QE-----TKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5323
+ + +G+ + +++ + + E N+R ++ + E+ + LP
Sbjct: 748 LDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQA--------SALPQ 799
Query: 5324 E-------------LSLQLAEVALDLKIRDQ-IQDKIKEVEQ-SKATSQELSRQIQKLAK 5368
E + + EVA ++R Q +QD + + S+A + EL I + +
Sbjct: 800 EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACEL--WIDEKEQ 857
Query: 5369 DLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAK 5428
L + K + V+Q + + L E++ S++ ++ ++ + K +
Sbjct: 858 WLNNMQIPEKLEDLEVIQHRFES--LEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKA 915
Query: 5429 KIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWI-EKAKVLAHGTIAWNS 5487
+ KL Q R+ +R +A ++ Y+ WI EK KV+ N
Sbjct: 916 QQDKLNTRWSQ-FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGND 974
Query: 5488 ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMS--QQVAELGRETEEL 5545
+ + + + I+++L + ++ + L S + + + ++AE+ EE+
Sbjct: 975 LAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEM 1034
Query: 5546 RQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLL 5605
+ +K R +L +A+K +++F +L Q+ L + Q + S + + L+ + LL
Sbjct: 1035 KTTLKNREASLGEASK-LQQFLRDLDDFQSWLSRTQTAIASED-----MPNTLTEAEKLL 1088
Query: 5606 SEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQ------HTAIQQC 5659
++ E++K ++ + +R ++V + L++ L H +
Sbjct: 1089 TQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENR 1148
Query: 5660 NIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKG 5719
+ + Y+Q+ ++ K + + + + T+ ++ +A I + E+ +
Sbjct: 1149 QNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTT-LEGAEAAIKKQEDFMTTMDA 1207
Query: 5720 YQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTA 5779
+E+I ++ + L + ++ + +D + T S
Sbjct: 1208 NEEKINAVVETGRRLVSDGN-----INSDRIQEKVDSIDDRHRKNRETAS---------- 1252
Query: 5780 GRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTD 5839
LL + + + + C+ S N QD++Y +A +
Sbjct: 1253 ----ELLMRLKDNRDLQKFLQD------CQELSLWINEKMLTAQDMSYDEARNLHSKWLK 1302
Query: 5840 AAKIHPSTSASQEFYE-------------PGLEPSATAKLGDLQRSWETLKNVISEKQRT 5886
++++E+ + P E KL L + WE L++ K +
Sbjct: 1303 HQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQR 1362
Query: 5887 LYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGR---SPESQMAEHQALMDEILMLQ 5943
L++A + + + S + + +E ++ +S + G+ S + + Q L +++ + +
Sbjct: 1363 LFDA-NKAELFTQSCADLDKWLHGLESQI-QSDDYGKDLTSVNILLKKQQMLENQMEVRK 1420
Query: 5944 DEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLND 6003
EI ELQS A+ L E D + LTV + M + K LL K
Sbjct: 1421 KEIEELQSQ-AQALSQEGKSTDEVD----SKRLTVQTKFMELLEPLNERKHNLLASKEIH 1475
Query: 6004 QLEEQRQEQALQRYRCEADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIE 6063
Q +++ L W + + L T+ ++ + Q + EI+
Sbjct: 1476 QFNRDVEDEIL------------W-VGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQ 1522
Query: 6064 QKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQGTA 6123
+ ++ ++N++ + + + + Q L++L G L+E H ++L A
Sbjct: 1523 GHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRH-RRLEEAHRA 1581
Query: 6124 QEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASR 6183
Q+ + A S +++ + Q S L++ + LEQ + + + ++
Sbjct: 1582 QQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKT 1641
Query: 6184 GEEILI-QHSAAETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLL 6242
++ H +E K D L G K AE++ R K + H+ F +++
Sbjct: 1642 SRALVADSHPESERISMRQSKVDKL-----YAGLKDLAEER-RGKLDERHRLFQLNREV- 1694
Query: 6243 QNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAK 6302
+ EQ + R +++G QD VT L + F E + +G
Sbjct: 1695 -----DDLEQWIAER--EVVAG-----SHELGQDYEHVTM----LQERFREFARDTGNIG 1738
Query: 6303 RQSI----HLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEM 6358
++ + HL +L + + + + + ++ L A A L E +T +ILA
Sbjct: 1739 QERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDT---RTQILA-----A 1790
Query: 6359 SEEMDKNKNLFSQAFPENGDNRDVIEDTLGCLLGRLSLLDSVVNQRCHQMKERLQQILNF 6418
S E+ K + + F D + + LG + L + H ++ Q+
Sbjct: 1791 SYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQL 1850
Query: 6419 QNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDK 6478
Q D L + A +K +QK N E ++ + L ++ + L GDK
Sbjct: 1851 QEDAARLQAAYAGDKADDIQKREN----------EVLEAWKSLLDACESRRVRLVDTGDK 1900
Query: 6479 LQVEQPSMQELSKLQDMY-----DELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLET 6533
+ + ++D+ E + S +N + +K++ + +E
Sbjct: 1901 FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIEL 1960
Query: 6534 GQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLES-----HMILTETLFRKIISFA---- 6584
G+ +A KE++ QL +K KE E +IL F + S A
Sbjct: 1961 GKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWL 2020
Query: 6585 VQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSR--QLEVVESSIP 6642
+ +E + + Q+ +++ KR E TW DE L R LE++E
Sbjct: 2021 LGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATW---DERFSALERLTTLELLE---- 2073
Query: 6643 SVGLVEENEDR 6653
V +E E+R
Sbjct: 2074 -VRRQQEEEER 2083
Score = 86.3 bits (212), Expect = 1e-15
Identities = 187/959 (19%), Positives = 387/959 (40%), Gaps = 112/959 (11%)
Query: 4818 FQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQEEVQS-SLRIMNALSHK 4876
F EM+ W+R + LS Y +L + + K + ++E+ S A+ K
Sbjct: 630 FFWEMAEEEGWIREKEKILSSDDY-GKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAI--K 686
Query: 4877 EKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAAND 4936
E E + S + + + E ++++ R+ L E Q FQA D
Sbjct: 687 EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQ-----FQADAD 741
Query: 4937 ----WLEDAQELLQLAGNGLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLI 4992
W+ D +++ + G D S + +K H + + L+ LH + L
Sbjct: 742 DIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-- 799
Query: 4993 KPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKAREEVIEL-MNDTEK 5051
+ D+ +++ +E R + ++ + + LQ A + + +A + EL +++ E+
Sbjct: 800 EHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEA--DACELWIDEKEQ 857
Query: 5052 KLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLS 5111
L+ + + E + E +L +N+ ++ + + A QL +G+ + K +
Sbjct: 858 WLNNMQIPEKLEDLEVIQHRFE--SLEPEMNNQASRVAVVNQIARQLMHSGHPSEKE-IK 914
Query: 5112 RSMTTVWQRWTRLRAVAQDQEKILEDAVD------EWTGFNNKVKKATEMIDQLQDKLPG 5165
+ RW++ R + ++ L A+ E + +++ T++I+ QD L
Sbjct: 915 AQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD-LGN 973
Query: 5166 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEPPLMQE 5225
A + LT +E D +E + LS LQ A E P Q
Sbjct: 974 DLAGVMALQRKLTGME-RDLVAIEAK-------------LSDLQKEAEKLESEHPDQAQA 1019
Query: 5226 ITAMQDRCLNMQEKVKTNGKLVKQELKDREMVET---QINSVKCWVQETKEYLGNPTIEI 5282
I + ++ E++KT K + L + ++ ++ + W+ T+ + + ++
Sbjct: 1020 ILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASE--DM 1077
Query: 5283 DAQLEELQILLTEATNHRQNIEKMAEE-QKEKYLGLYTILPSELSLQLAEVALDLKIRDQ 5341
L E + LLT+ N + I+ E+ QK + +G + + Q + L+ D
Sbjct: 1078 PNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMG-EMVTQGQTDAQYMFLRQRLQALDT 1136
Query: 5342 IQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGC 5401
+++ ++ +++ S Q+ +D T + V A T+ E +
Sbjct: 1137 GWNELHKMWENRQNLLSQSHAYQQFLRD--TKQAEAFLNNQEYVLAHTEMPTTLEGAEAA 1194
Query: 5402 NSK----LMELDAAVQKF---------LEQNGQLGKP-LAKKIGKLTELHQQTIRQAENR 5447
K + +DA +K L +G + + +K+ + + H++ A
Sbjct: 1195 IKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASEL 1254
Query: 5448 LSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQLREQYILHQTLLEE--- 5504
L +L + + EL L WI + K+L ++++ A L +++ HQ + E
Sbjct: 1255 LMRLKDNRDLQKFLQDCQELSL-WINE-KMLTAQDMSYDEARNLHSKWLKHQAFMAELAS 1312
Query: 5505 SKEIDSELEAMTEKLQYLTSVYCTEKM-SQQVAELGRETEELRQMIKIRLQNLQDAAKDM 5563
+KE ++E E +Q ++ TE + +++ L + E L + + Q L DA K
Sbjct: 1313 NKEWLDKIEK--EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANK-A 1369
Query: 5564 KKFEAELKKLQAALEQAQATLTSPEVGR--LSLKEQLSHRQHLLSEMESLKPKVQAVQLC 5621
+ F L L ++ + S + G+ S+ L +Q L ++ME K +++ +Q
Sbjct: 1370 ELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQ-- 1427
Query: 5622 QSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYEQYEQEMKH--- 5678
A L +E ++ + Q ++ + E KH
Sbjct: 1428 -----------------SQAQALSQEGKSTDEVDSKRLTV-QTKFMELLEPLNERKHNLL 1469
Query: 5679 LQQLIEGAHREIEDK--------PVATS-----NIQELQAQISRHEELAQKIKGYQEQI 5724
+ I +R++ED+ P+ATS N+Q +Q I +++ L ++I+G+Q +I
Sbjct: 1470 ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRI 1528
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.128 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 298,714,641
Number of Sequences: 37866
Number of extensions: 13008425
Number of successful extensions: 85071
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 180
Number of HSP's successfully gapped in prelim test: 1078
Number of HSP's that attempted gapping in prelim test: 45827
Number of HSP's gapped (non-prelim): 20879
length of query: 8749
length of database: 18,247,518
effective HSP length: 128
effective length of query: 8621
effective length of database: 13,400,670
effective search space: 115527176070
effective search space used: 115527176070
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 75 (33.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.