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Search of human proteins with 22907052
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22907052 actin related protein 2/3 complex subunit 1A [Homo
sapiens]
(370 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22907052 actin related protein 2/3 complex subunit 1A [Homo s... 768 0.0
gi|5031601 actin related protein 2/3 complex subunit 1B [Homo sa... 551 e-157
gi|89026256 PREDICTED: similar to actin related protein 2/3 comp... 520 e-148
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 59 5e-09
gi|4757988 WD repeat domain 39 [Homo sapiens] 58 2e-08
gi|19913367 transducin beta-like 1Y [Homo sapiens] 57 3e-08
gi|19913365 transducin beta-like 1Y [Homo sapiens] 57 3e-08
gi|15150805 transducin beta-like 1Y [Homo sapiens] 57 3e-08
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 54 2e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 54 2e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 54 2e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 54 2e-07
gi|210032390 SEC13 protein isoform 2 [Homo sapiens] 47 4e-05
gi|34335134 SEC13 protein isoform 1 [Homo sapiens] 47 4e-05
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 44 2e-04
gi|46409657 WD repeat domain 56 [Homo sapiens] 44 2e-04
gi|58331266 WD repeat domain 59 [Homo sapiens] 44 3e-04
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 43 5e-04
gi|55953102 tubby like protein 4 isoform 2 [Homo sapiens] 42 9e-04
gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens] 42 9e-04
gi|23199987 WD repeat domain 5B [Homo sapiens] 42 0.001
gi|118402582 cell division cycle 20 [Homo sapiens] 40 0.003
gi|21536485 HIR histone cell cycle regulation defective homolog ... 40 0.003
gi|26665869 WD repeat domain 51B [Homo sapiens] 40 0.003
gi|30089954 H326 [Homo sapiens] 40 0.003
gi|21071067 TBP-associated factor 5 [Homo sapiens] 40 0.004
gi|7549793 transducin (beta)-like 2 [Homo sapiens] 40 0.004
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa... 40 0.004
gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens] 38 0.013
gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens] 38 0.013
>gi|22907052 actin related protein 2/3 complex subunit 1A [Homo
sapiens]
Length = 370
Score = 768 bits (1984), Expect = 0.0
Identities = 370/370 (100%), Positives = 370/370 (100%)
Query: 1 MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW 60
MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW
Sbjct: 1 MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW 60
Query: 61 APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI 120
APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI
Sbjct: 61 APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI 120
Query: 121 SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP 180
SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP
Sbjct: 121 SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP 180
Query: 181 ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS 240
ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS
Sbjct: 181 ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS 240
Query: 241 TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAM 300
TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAM
Sbjct: 241 TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAM 300
Query: 301 ERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTL 360
ERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTL
Sbjct: 301 ERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTL 360
Query: 361 ESSIQGLRIM 370
ESSIQGLRIM
Sbjct: 361 ESSIQGLRIM 370
>gi|5031601 actin related protein 2/3 complex subunit 1B [Homo
sapiens]
Length = 372
Score = 551 bits (1421), Expect = e-157
Identities = 254/373 (68%), Positives = 315/373 (84%), Gaps = 6/373 (1%)
Query: 1 MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDW 60
M+ H FL+EPI+CHAWN+DRTQIA+ PNNHEVHIY+K+G++W K HELKEHNG +TGIDW
Sbjct: 1 MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDW 60
Query: 61 APKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI 120
AP+S+RIVTCG DRNAYVW+ K WKPTLVILRINRAA V+W+P ENKFAVGSG+R+I
Sbjct: 61 APESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVI 120
Query: 121 SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKP 180
S+CYFE ENDWWV KHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCR+FSAYIKEV+E+P
Sbjct: 121 SICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERP 180
Query: 181 ASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVS 240
A TPWGSKMPFG+LM F S + GWVHGV FSASGSR+AWVSHDSTV +ADA K + V+
Sbjct: 181 APTPWGSKMPFGELM--FESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVA 238
Query: 241 TLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYD-DRGCLTFVSKLDIPKQSIQRNMSA 299
TL +E LPLL+++F+++NS+VAAGHDC P+LF YD G L+F +LD+PKQS QR ++A
Sbjct: 239 TLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTA 298
Query: 300 MERFRNMDKRATTEDRNTA---LETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWD 356
ERF+N+DK+A++E A L++LH+NS++Q+S+ K C +FCTTG+DG M+IWD
Sbjct: 299 RERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWD 358
Query: 357 FKTLESSIQGLRI 369
K+LES+++ L+I
Sbjct: 359 VKSLESALKDLKI 371
>gi|89026256 PREDICTED: similar to actin related protein 2/3 complex
subunit 1B [Homo sapiens]
Length = 370
Score = 520 bits (1339), Expect = e-148
Identities = 241/356 (67%), Positives = 300/356 (84%), Gaps = 6/356 (1%)
Query: 18 RDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAY 77
+DRTQIA+ PNNHEVHIY+K+G++W K HELKEHNG +TGIDWAP+S+RIVTCG DRNAY
Sbjct: 16 KDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAY 75
Query: 78 VWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHI 137
VW+ K WKPTLVILRINRAA V+W+P ENKFAVGSG+R+IS+CYFE ENDWWV KHI
Sbjct: 76 VWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHI 135
Query: 138 KKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSE 197
KKPIRSTVLSLDWHPNNVLLAAGSCDFKCR+FSAYIKEV+E+PA TPWGSKMPFG+LM
Sbjct: 136 KKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELM-- 193
Query: 198 FGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSE 257
F S + GWVHGV FSASGSR+AWVSHDSTV +ADA K + V+TL +E LPL++++F+++
Sbjct: 194 FESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLVALTFITD 253
Query: 258 NSVVAAGHDCCPMLFNYD-DRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRN 316
NS+VAAGHDC P+LF YD G L+F +LD+PKQS QR ++A ERF+N+DK+A++E
Sbjct: 254 NSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGT 313
Query: 317 TA---LETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRI 369
A L++LH+NS++Q+S+ K C +FCTTG+DG M+IWD K+LES+++ L+I
Sbjct: 314 AAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKI 369
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 59.3 bits (142), Expect = 5e-09
Identities = 70/282 (24%), Positives = 110/282 (39%), Gaps = 58/282 (20%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN + T +A + I+ K+G+ A L +H G I + W K + I++
Sbjct: 228 VTSLDWNSEGTLLATGSYDGFARIWTKDGNL---ASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W N FA S I VC +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQS-NNTFASCSTDMCIHVCKLGQD-- 339
Query: 131 WWVSKHIKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYI 173
+PI+ + V ++ W P LLA+ S D +++S A+
Sbjct: 340 --------RPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHN 391
Query: 174 KEV-DEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVAD 232
KE+ K + T G+ P LM LA S DSTV + D
Sbjct: 392 KEIYTIKWSPTGPGTNNPNANLM-----------------------LASASFDSTVRLWD 428
Query: 233 ASKSVQVSTLKTEFLPLLSVSFVSENSVVAAG-HDCCPMLFN 273
+ + + TL P+ SV+F + +A+G D C ++N
Sbjct: 429 VDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWN 470
Score = 40.0 bits (92), Expect = 0.003
Identities = 44/189 (23%), Positives = 69/189 (36%), Gaps = 32/189 (16%)
Query: 91 VILRINRAATFV-KWSPLENKFAVGSGARLISVCYFE----SENDWWVSKHIKK------ 139
V+LR + + F+ W+P+ + A GSG + S + V +H +
Sbjct: 163 VVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDV 222
Query: 140 PIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFG 199
P V SLDW+ LLA GS D R+++ D AST K P
Sbjct: 223 PSNKDVTSLDWNSEGTLLATGSYDGFARIWTK-----DGNLASTLGQHKGP--------- 268
Query: 200 GSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENS 259
+ + ++ G+ + D T + DA P L V + S N+
Sbjct: 269 -------IFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT 321
Query: 260 VVAAGHDCC 268
+ D C
Sbjct: 322 FASCSTDMC 330
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 57.8 bits (138), Expect = 2e-08
Identities = 39/160 (24%), Positives = 70/160 (43%), Gaps = 3/160 (1%)
Query: 15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADR 74
AW+ +A + + I+KKN + L+ H + + WAP + + TC D+
Sbjct: 68 AWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDK 127
Query: 75 NAYVWS-QKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWV 133
+ +VW ++ ++ V+ + V W P + A S + + + E D WV
Sbjct: 128 SVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL--YREEEDDWV 185
Query: 134 SKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYI 173
+ STV SL + P+ LA+ S D R++ Y+
Sbjct: 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYL 225
Score = 54.3 bits (129), Expect = 2e-07
Identities = 47/217 (21%), Positives = 82/217 (37%), Gaps = 20/217 (9%)
Query: 15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKE-HNGHITGIDWAPKSDRIVTCGAD 73
AWN T +A + + I+ G W+ L E H + + W+P + + + D
Sbjct: 23 AWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFD 82
Query: 74 RNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWV 133
+W + ++ + V W+P N A S + + V + E+++
Sbjct: 83 ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYEC 142
Query: 134 SKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQ 193
+ + V + WHP+ LLA+ S D ++ Y +E D+
Sbjct: 143 VSVLNSHTQD-VKHVVWHPSQELLASASYDDTVKL---YREEEDDWVCCATL-------- 190
Query: 194 LMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSV 230
G V ++F SG RLA S D TV +
Sbjct: 191 -------EGHESTVWSLAFDPSGQRLASCSDDRTVRI 220
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 57.0 bits (136), Expect = 3e-08
Identities = 65/268 (24%), Positives = 102/268 (38%), Gaps = 49/268 (18%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN D T +A+ + I+ +NG+ A L +H G I + W K + +++
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL---ASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W FA S I VC +
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQN-NMTFASCSTDMCIHVCRLGCD-- 349
Query: 131 WWVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYIKEV 176
H K + + V ++ W P+ +LLA+ S D +++S A+ KE+
Sbjct: 350 -----HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEI 404
Query: 177 DEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKS 236
+ W P S S LA S DSTV + D +
Sbjct: 405 ----YTIKWSPTGP------------------ATSNPNSSIMLASASFDSTVRLWDVEQG 442
Query: 237 VQVSTLKTEFLPLLSVSFVSENSVVAAG 264
V TL P+ SV+F + +A+G
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/195 (22%), Positives = 76/195 (38%), Gaps = 31/195 (15%)
Query: 46 HELKEHNGH---ITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFV 102
H +K GH + I W P + +C D +WS K L ++ +
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL--QAHSKEIYTI 407
Query: 103 KWSPLENKFAVGSGARLISVCYFESENDWW-----VSKHIKKPIRSTVLSLDWHPNNVLL 157
KWSP + + + +++ F+S W V H + V S+ + P+ L
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 158 AAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGS 217
A+GS D + W ++ G L+ + GTGG + V ++A G
Sbjct: 468 ASGSFDKYVHI----------------WNTQS--GSLVHSY--QGTGG-IFEVCWNARGD 506
Query: 218 RLAWVSHDSTVSVAD 232
++ + D +V V D
Sbjct: 507 KVGASASDGSVCVLD 521
Score = 35.0 bits (79), Expect = 0.11
Identities = 53/246 (21%), Positives = 86/246 (34%), Gaps = 44/246 (17%)
Query: 27 PNNHEVHIY-KKNGSQWVKAHELKEHNG--HITGIDWAPKSDRIVTCGADRNAYVWSQKD 83
P N E + ++NG AHE+ H+ I G P + V G + ++ +
Sbjct: 135 PKNREATVNGEENG-----AHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICA--- 186
Query: 84 GVWKPTLVILRINRAATFVK-WSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIR 142
W P +L + + W+ EN GS ++ C E +D P
Sbjct: 187 --WNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHD--------VPSN 235
Query: 143 STVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSG 202
V SLDW+ + LLA GS D R+++ G L S G
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWTEN-------------------GNLASTLGQH- 275
Query: 203 TGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVA 262
G + + ++ G+ + D T + DA P L V + + + +
Sbjct: 276 -KGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFAS 334
Query: 263 AGHDCC 268
D C
Sbjct: 335 CSTDMC 340
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 57.0 bits (136), Expect = 3e-08
Identities = 65/268 (24%), Positives = 102/268 (38%), Gaps = 49/268 (18%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN D T +A+ + I+ +NG+ A L +H G I + W K + +++
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL---ASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W FA S I VC +
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQN-NMTFASCSTDMCIHVCRLGCD-- 349
Query: 131 WWVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYIKEV 176
H K + + V ++ W P+ +LLA+ S D +++S A+ KE+
Sbjct: 350 -----HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEI 404
Query: 177 DEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKS 236
+ W P S S LA S DSTV + D +
Sbjct: 405 ----YTIKWSPTGP------------------ATSNPNSSIMLASASFDSTVRLWDVEQG 442
Query: 237 VQVSTLKTEFLPLLSVSFVSENSVVAAG 264
V TL P+ SV+F + +A+G
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/195 (22%), Positives = 76/195 (38%), Gaps = 31/195 (15%)
Query: 46 HELKEHNGH---ITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFV 102
H +K GH + I W P + +C D +WS K L ++ +
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL--QAHSKEIYTI 407
Query: 103 KWSPLENKFAVGSGARLISVCYFESENDWW-----VSKHIKKPIRSTVLSLDWHPNNVLL 157
KWSP + + + +++ F+S W V H + V S+ + P+ L
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 158 AAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGS 217
A+GS D + W ++ G L+ + GTGG + V ++A G
Sbjct: 468 ASGSFDKYVHI----------------WNTQS--GSLVHSY--QGTGG-IFEVCWNARGD 506
Query: 218 RLAWVSHDSTVSVAD 232
++ + D +V V D
Sbjct: 507 KVGASASDGSVCVLD 521
Score = 35.0 bits (79), Expect = 0.11
Identities = 53/246 (21%), Positives = 86/246 (34%), Gaps = 44/246 (17%)
Query: 27 PNNHEVHIY-KKNGSQWVKAHELKEHNG--HITGIDWAPKSDRIVTCGADRNAYVWSQKD 83
P N E + ++NG AHE+ H+ I G P + V G + ++ +
Sbjct: 135 PKNREATVNGEENG-----AHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICA--- 186
Query: 84 GVWKPTLVILRINRAATFVK-WSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIR 142
W P +L + + W+ EN GS ++ C E +D P
Sbjct: 187 --WNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHD--------VPSN 235
Query: 143 STVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSG 202
V SLDW+ + LLA GS D R+++ G L S G
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWTEN-------------------GNLASTLGQH- 275
Query: 203 TGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVA 262
G + + ++ G+ + D T + DA P L V + + + +
Sbjct: 276 -KGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFAS 334
Query: 263 AGHDCC 268
D C
Sbjct: 335 CSTDMC 340
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 57.0 bits (136), Expect = 3e-08
Identities = 65/268 (24%), Positives = 102/268 (38%), Gaps = 49/268 (18%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN D T +A+ + I+ +NG+ A L +H G I + W K + +++
Sbjct: 238 VTSLDWNSDGTLLAMGSYDGFARIWTENGNL---ASTLGQHKGPIFALKWNKKGNYVLSA 294
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W FA S I VC +
Sbjct: 295 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQN-NMTFASCSTDMCIHVCRLGCD-- 349
Query: 131 WWVSKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYIKEV 176
H K + + V ++ W P+ +LLA+ S D +++S A+ KE+
Sbjct: 350 -----HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEI 404
Query: 177 DEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKS 236
+ W P S S LA S DSTV + D +
Sbjct: 405 ----YTIKWSPTGP------------------ATSNPNSSIMLASASFDSTVRLWDVEQG 442
Query: 237 VQVSTLKTEFLPLLSVSFVSENSVVAAG 264
V TL P+ SV+F + +A+G
Sbjct: 443 VCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Score = 43.5 bits (101), Expect = 3e-04
Identities = 44/195 (22%), Positives = 76/195 (38%), Gaps = 31/195 (15%)
Query: 46 HELKEHNGH---ITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFV 102
H +K GH + I W P + +C D +WS K L ++ +
Sbjct: 350 HPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDL--QAHSKEIYTI 407
Query: 103 KWSPLENKFAVGSGARLISVCYFESENDWW-----VSKHIKKPIRSTVLSLDWHPNNVLL 157
KWSP + + + +++ F+S W V H + V S+ + P+ L
Sbjct: 408 KWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYL 467
Query: 158 AAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGS 217
A+GS D + W ++ G L+ + GTGG + V ++A G
Sbjct: 468 ASGSFDKYVHI----------------WNTQS--GSLVHSY--QGTGG-IFEVCWNARGD 506
Query: 218 RLAWVSHDSTVSVAD 232
++ + D +V V D
Sbjct: 507 KVGASASDGSVCVLD 521
Score = 35.0 bits (79), Expect = 0.11
Identities = 53/246 (21%), Positives = 86/246 (34%), Gaps = 44/246 (17%)
Query: 27 PNNHEVHIY-KKNGSQWVKAHELKEHNG--HITGIDWAPKSDRIVTCGADRNAYVWSQKD 83
P N E + ++NG AHE+ H+ I G P + V G + ++ +
Sbjct: 135 PKNREATVNGEENG-----AHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICA--- 186
Query: 84 GVWKPTLVILRINRAATFVK-WSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIR 142
W P +L + + W+ EN GS ++ C E +D P
Sbjct: 187 --WNPVSDLLASGSGDSTARIWNLNENSNG-GSTQLVLRHCIREGGHD--------VPSN 235
Query: 143 STVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSG 202
V SLDW+ + LLA GS D R+++ G L S G
Sbjct: 236 KDVTSLDWNSDGTLLAMGSYDGFARIWTEN-------------------GNLASTLGQH- 275
Query: 203 TGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVA 262
G + + ++ G+ + D T + DA P L V + + + +
Sbjct: 276 -KGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFAS 334
Query: 263 AGHDCC 268
D C
Sbjct: 335 CSTDMC 340
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 53.9 bits (128), Expect = 2e-07
Identities = 66/281 (23%), Positives = 107/281 (38%), Gaps = 56/281 (19%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN + T +A + I+ ++G+ A L +H G I + W K + I++
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL---ASTLGQHKGPIFALKWNRKGNYILSA 296
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W FA S I VC +
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQN-NTTFASCSTDMCIHVCRLGCD-- 351
Query: 131 WWVSKHIKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYI 173
+P++ + V ++ W P+ +LLA+ S D +++S A+
Sbjct: 352 --------RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 403
Query: 174 KEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADA 233
KE+ + W P S S LA S DSTV + D
Sbjct: 404 KEI----YTIKWSPTGP------------------ATSNPNSNIMLASASFDSTVRLWDI 441
Query: 234 SKSVQVSTLKTEFLPLLSVSFVSENSVVAAG-HDCCPMLFN 273
+ V TL P+ SV+F + +A+G D C ++N
Sbjct: 442 ERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482
Score = 45.8 bits (107), Expect = 6e-05
Identities = 52/223 (23%), Positives = 89/223 (39%), Gaps = 30/223 (13%)
Query: 18 RDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAY 77
++ T A + +H+ + + VK + H + I W P + +C D
Sbjct: 329 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 386
Query: 78 VWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWW----- 132
+WS K V L N+ +KWSP + + +++ F+S W
Sbjct: 387 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444
Query: 133 VSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFG 192
V H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 486
Query: 193 QLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASK 235
L+ + GTGG + V ++A G ++ + D +V V D K
Sbjct: 487 NLVHSY--RGTGG-IFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 38.5 bits (88), Expect = 0.010
Identities = 47/225 (20%), Positives = 71/225 (31%), Gaps = 55/225 (24%)
Query: 44 KAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVK 103
KA L+ H + W P SD + + D A +W+
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN----------------------- 209
Query: 104 WSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
L GS ++ C E +D P V SLDW+ N LLA GS D
Sbjct: 210 ---LNENSNGGSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSYD 258
Query: 164 FKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVS 223
R+++ D AST K P + + ++ G+ +
Sbjct: 259 GFARIWTE-----DGNLASTLGQHKGP----------------IFALKWNRKGNYILSAG 297
Query: 224 HDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCC 268
D T + DA P L V + + + + D C
Sbjct: 298 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMC 342
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 53.9 bits (128), Expect = 2e-07
Identities = 66/281 (23%), Positives = 107/281 (38%), Gaps = 56/281 (19%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN + T +A + I+ ++G+ A L +H G I + W K + I++
Sbjct: 240 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL---ASTLGQHKGPIFALKWNRKGNYILSA 296
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W FA S I VC +
Sbjct: 297 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQN-NTTFASCSTDMCIHVCRLGCD-- 351
Query: 131 WWVSKHIKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYI 173
+P++ + V ++ W P+ +LLA+ S D +++S A+
Sbjct: 352 --------RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 403
Query: 174 KEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADA 233
KE+ + W P S S LA S DSTV + D
Sbjct: 404 KEI----YTIKWSPTGP------------------ATSNPNSNIMLASASFDSTVRLWDI 441
Query: 234 SKSVQVSTLKTEFLPLLSVSFVSENSVVAAG-HDCCPMLFN 273
+ V TL P+ SV+F + +A+G D C ++N
Sbjct: 442 ERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 482
Score = 45.8 bits (107), Expect = 6e-05
Identities = 52/223 (23%), Positives = 89/223 (39%), Gaps = 30/223 (13%)
Query: 18 RDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAY 77
++ T A + +H+ + + VK + H + I W P + +C D
Sbjct: 329 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 386
Query: 78 VWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWW----- 132
+WS K V L N+ +KWSP + + +++ F+S W
Sbjct: 387 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 444
Query: 133 VSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFG 192
V H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 486
Query: 193 QLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASK 235
L+ + GTGG + V ++A G ++ + D +V V D K
Sbjct: 487 NLVHSY--RGTGG-IFEVCWNARGDKVGASASDGSVCVLDLRK 526
Score = 38.5 bits (88), Expect = 0.010
Identities = 47/225 (20%), Positives = 71/225 (31%), Gaps = 55/225 (24%)
Query: 44 KAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVK 103
KA L+ H + W P SD + + D A +W+
Sbjct: 173 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN----------------------- 209
Query: 104 WSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
L GS ++ C E +D P V SLDW+ N LLA GS D
Sbjct: 210 ---LNENSNGGSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSYD 258
Query: 164 FKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVS 223
R+++ D AST K P + + ++ G+ +
Sbjct: 259 GFARIWTE-----DGNLASTLGQHKGP----------------IFALKWNRKGNYILSAG 297
Query: 224 HDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCC 268
D T + DA P L V + + + + D C
Sbjct: 298 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMC 342
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 53.9 bits (128), Expect = 2e-07
Identities = 66/281 (23%), Positives = 107/281 (38%), Gaps = 56/281 (19%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN + T +A + I+ ++G+ A L +H G I + W K + I++
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL---ASTLGQHKGPIFALKWNRKGNYILSA 347
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W FA S I VC +
Sbjct: 348 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQN-NTTFASCSTDMCIHVCRLGCD-- 402
Query: 131 WWVSKHIKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYI 173
+P++ + V ++ W P+ +LLA+ S D +++S A+
Sbjct: 403 --------RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 454
Query: 174 KEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADA 233
KE+ + W P S S LA S DSTV + D
Sbjct: 455 KEI----YTIKWSPTGP------------------ATSNPNSNIMLASASFDSTVRLWDI 492
Query: 234 SKSVQVSTLKTEFLPLLSVSFVSENSVVAAG-HDCCPMLFN 273
+ V TL P+ SV+F + +A+G D C ++N
Sbjct: 493 ERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 533
Score = 45.8 bits (107), Expect = 6e-05
Identities = 52/223 (23%), Positives = 89/223 (39%), Gaps = 30/223 (13%)
Query: 18 RDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAY 77
++ T A + +H+ + + VK + H + I W P + +C D
Sbjct: 380 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 437
Query: 78 VWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWW----- 132
+WS K V L N+ +KWSP + + +++ F+S W
Sbjct: 438 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
Query: 133 VSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFG 192
V H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 537
Query: 193 QLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASK 235
L+ + GTGG + V ++A G ++ + D +V V D K
Sbjct: 538 NLVHSY--RGTGG-IFEVCWNARGDKVGASASDGSVCVLDLRK 577
Score = 38.5 bits (88), Expect = 0.010
Identities = 47/225 (20%), Positives = 71/225 (31%), Gaps = 55/225 (24%)
Query: 44 KAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVK 103
KA L+ H + W P SD + + D A +W+
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN----------------------- 260
Query: 104 WSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
L GS ++ C E +D P V SLDW+ N LLA GS D
Sbjct: 261 ---LNENSNGGSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSYD 309
Query: 164 FKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVS 223
R+++ D AST K P + + ++ G+ +
Sbjct: 310 GFARIWTE-----DGNLASTLGQHKGP----------------IFALKWNRKGNYILSAG 348
Query: 224 HDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCC 268
D T + DA P L V + + + + D C
Sbjct: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMC 393
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 53.9 bits (128), Expect = 2e-07
Identities = 66/281 (23%), Positives = 107/281 (38%), Gaps = 56/281 (19%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTC 70
+T WN + T +A + I+ ++G+ A L +H G I + W K + I++
Sbjct: 291 VTSLDWNTNGTLLATGSYDGFARIWTEDGNL---ASTLGQHKGPIFALKWNRKGNYILSA 347
Query: 71 GADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
G D+ +W G K + A V W FA S I VC +
Sbjct: 348 GVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQN-NTTFASCSTDMCIHVCRLGCD-- 402
Query: 131 WWVSKHIKKPIR------STVLSLDWHPNNVLLAAGSCDFKCRVFS-----------AYI 173
+P++ + V ++ W P+ +LLA+ S D +++S A+
Sbjct: 403 --------RPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHN 454
Query: 174 KEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADA 233
KE+ + W P S S LA S DSTV + D
Sbjct: 455 KEI----YTIKWSPTGP------------------ATSNPNSNIMLASASFDSTVRLWDI 492
Query: 234 SKSVQVSTLKTEFLPLLSVSFVSENSVVAAG-HDCCPMLFN 273
+ V TL P+ SV+F + +A+G D C ++N
Sbjct: 493 ERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 533
Score = 45.8 bits (107), Expect = 6e-05
Identities = 52/223 (23%), Positives = 89/223 (39%), Gaps = 30/223 (13%)
Query: 18 RDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAY 77
++ T A + +H+ + + VK + H + I W P + +C D
Sbjct: 380 QNNTTFASCSTDMCIHVCRLGCDRPVKTFQ--GHTNEVNAIKWDPSGMLLASCSDDMTLK 437
Query: 78 VWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWW----- 132
+WS K V L N+ +KWSP + + +++ F+S W
Sbjct: 438 IWSMKQEVCIHDL--QAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG 495
Query: 133 VSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFG 192
V H + V S+ + P+ LA+GS D KC +I W ++ G
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFD-KC----VHI-----------WNTQS--G 537
Query: 193 QLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASK 235
L+ + GTGG + V ++A G ++ + D +V V D K
Sbjct: 538 NLVHSY--RGTGG-IFEVCWNARGDKVGASASDGSVCVLDLRK 577
Score = 38.5 bits (88), Expect = 0.010
Identities = 47/225 (20%), Positives = 71/225 (31%), Gaps = 55/225 (24%)
Query: 44 KAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVK 103
KA L+ H + W P SD + + D A +W+
Sbjct: 224 KATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWN----------------------- 260
Query: 104 WSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
L GS ++ C E +D P V SLDW+ N LLA GS D
Sbjct: 261 ---LNENSNGGSTQLVLRHCIREGGHD--------VPSNKDVTSLDWNTNGTLLATGSYD 309
Query: 164 FKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVS 223
R+++ D AST K P + + ++ G+ +
Sbjct: 310 GFARIWTE-----DGNLASTLGQHKGP----------------IFALKWNRKGNYILSAG 348
Query: 224 HDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCC 268
D T + DA P L V + + + + D C
Sbjct: 349 VDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMC 393
>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
Length = 308
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/120 (25%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 21 TQIALSPNNHEVHIYK-KNGSQWVKAHELKEHNGHITGIDWAPK--SDRIVTCGADRNAY 77
T++A ++ V I+ +NG Q + A +L+ H G + + WA + + +C DR
Sbjct: 12 TRLATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 70
Query: 78 VWSQKDGVWKPTLVILRINRAATFVKWSPLENK--FAVGSGARLISVCYFESENDWWVSK 135
+W +++G W+ + + + V W+P + A GS IS+ + E W V K
Sbjct: 71 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 130
Score = 40.0 bits (92), Expect = 0.003
Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 35/187 (18%)
Query: 29 NHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKS-DRIVTCGADRNA--YVWSQKDGV 85
+ +V I+++ W K+HE H+ + + WAP I+ CG+ A + +G
Sbjct: 66 DRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQ 125
Query: 86 WKPTLVILRINRAATF----VKWSPLE-----------------NKFAVGSGARLISVCY 124
W+ + +IN A T V W+P +FA G LI + +
Sbjct: 126 WE----VKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKL-W 180
Query: 125 FESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAA--GSCDFKCRVFSAYIKEVDEKPAS 182
E E+ W + + V + W P+ L + SC RVF I D+ ++
Sbjct: 181 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF---IWTCDDASSN 237
Query: 183 TPWGSKM 189
T W K+
Sbjct: 238 T-WSPKL 243
>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
Length = 322
Score = 46.6 bits (109), Expect = 4e-05
Identities = 31/120 (25%), Positives = 57/120 (47%), Gaps = 6/120 (5%)
Query: 21 TQIALSPNNHEVHIYK-KNGSQWVKAHELKEHNGHITGIDWAPK--SDRIVTCGADRNAY 77
T++A ++ V I+ +NG Q + A +L+ H G + + WA + + +C DR
Sbjct: 26 TRLATCSSDRSVKIFDVRNGGQILIA-DLRGHEGPVWQVAWAHPMYGNILASCSYDRKVI 84
Query: 78 VWSQKDGVWKPTLVILRINRAATFVKWSPLENK--FAVGSGARLISVCYFESENDWWVSK 135
+W +++G W+ + + + V W+P + A GS IS+ + E W V K
Sbjct: 85 IWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKK 144
Score = 40.0 bits (92), Expect = 0.003
Identities = 45/187 (24%), Positives = 75/187 (40%), Gaps = 35/187 (18%)
Query: 29 NHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKS-DRIVTCGADRNA--YVWSQKDGV 85
+ +V I+++ W K+HE H+ + + WAP I+ CG+ A + +G
Sbjct: 80 DRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQ 139
Query: 86 WKPTLVILRINRAATF----VKWSPLE-----------------NKFAVGSGARLISVCY 124
W+ + +IN A T V W+P +FA G LI + +
Sbjct: 140 WE----VKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKL-W 194
Query: 125 FESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAA--GSCDFKCRVFSAYIKEVDEKPAS 182
E E+ W + + V + W P+ L + SC RVF I D+ ++
Sbjct: 195 KEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVF---IWTCDDASSN 251
Query: 183 TPWGSKM 189
T W K+
Sbjct: 252 T-WSPKL 257
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 44.3 bits (103), Expect = 2e-04
Identities = 61/259 (23%), Positives = 102/259 (39%), Gaps = 30/259 (11%)
Query: 16 WNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRI-VTCGADR 74
+ +D+ +A NN + I+ + + L +H + + +AP I V+ D+
Sbjct: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLL--NLVDHTEVVRDLTFAPDGSLILVSASRDK 193
Query: 75 NAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVS 134
VW KD + +LR ++ + ++ GA S F D +
Sbjct: 194 TLRVWDLKDD--GNMMKVLRGHQNWVYSCAFSPDSSMLCSVGA---SKAVFLWNMDKYTM 248
Query: 135 KHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQL 194
+ V++ D+ P+ LLA S D + ++ + ++ M FG L
Sbjct: 249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDI-----------LMEFGHL 297
Query: 195 MSE----FGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSV--ADASKSVQVSTLKTEFLP 248
F G WV VSFS G +A ++ D V D VQV+ L
Sbjct: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--- 354
Query: 249 LLSVSFVSENSVVAAG-HD 266
L +F ++ SV+AAG HD
Sbjct: 355 -LCCAFSTDGSVLAAGTHD 372
>gi|46409657 WD repeat domain 56 [Homo sapiens]
Length = 777
Score = 43.9 bits (102), Expect = 2e-04
Identities = 40/166 (24%), Positives = 69/166 (41%), Gaps = 13/166 (7%)
Query: 10 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVT 69
P+ AW D ++ + + K K + K H+G I +DW +D I++
Sbjct: 149 PVYSVAWGPDSEKVLYTAGKQ---LIIKPLQPNAKVLQWKAHDGIILKVDWNSVNDLILS 205
Query: 70 CGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEN 129
G D VW D +P T V W+P FAVGS + +C +
Sbjct: 206 AGEDCKYKVW---DSYGRPLYNSQPHEHPITSVAWAPDGELFAVGS-FHTLRLC---DKT 258
Query: 130 DWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKE 175
W S ++KP ++ ++ W + + AG+C VF+ +++
Sbjct: 259 GW--SYALEKPNTGSIFNIAWSIDGTQI-AGACGNGHVVFAHVVEQ 301
Score = 35.4 bits (80), Expect = 0.083
Identities = 35/150 (23%), Positives = 60/150 (40%), Gaps = 15/150 (10%)
Query: 25 LSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDG 84
L+ ++ + H+ K G ++ H G + W + +VT G D +WS K G
Sbjct: 82 LTSSDGKFHLISKLGRV---EKSVEAHCGAVLAGRWNYEGTALVTVGEDGQIKIWS-KTG 137
Query: 85 VWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEN--DWWVSKHIKKPIR 142
+ + TL + V W P K +G +LI + W K
Sbjct: 138 MLRSTLA--QQGTPVYSVAWGPDSEKVLYTAGKQLIIKPLQPNAKVLQW-------KAHD 188
Query: 143 STVLSLDWHPNNVLLAAGSCDFKCRVFSAY 172
+L +DW+ N L+ + D K +V+ +Y
Sbjct: 189 GIILKVDWNSVNDLILSAGEDCKYKVWDSY 218
>gi|58331266 WD repeat domain 59 [Homo sapiens]
Length = 974
Score = 43.5 bits (101), Expect = 3e-04
Identities = 42/149 (28%), Positives = 67/149 (44%), Gaps = 29/149 (19%)
Query: 28 NNHEVHIYK-KNGSQWVKAHELKEHNGHITGIDWAP-KSDRIVTCGADRNAYVWSQKDGV 85
+N V +YK K+GS V L+ H I+ +DWA + D +VT D Y+W KD
Sbjct: 81 SNQRVDLYKWKDGSGEVGT-TLQGHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKD-T 138
Query: 86 WKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDW----------WVSK 135
KPT+ + + A+ VKW+ A ++ + W +++
Sbjct: 139 RKPTVALSAV-AGASQVKWNK--------KNANCLATSHDGDVRIWDKRKPSTAVEYLAA 189
Query: 136 HIKKPIRSTVLSLDWHPNNV-LLAAGSCD 163
H+ K + LDWHP++ +LA S D
Sbjct: 190 HLSK-----IHGLDWHPDSEHILATSSQD 213
Score = 30.8 bits (68), Expect = 2.0
Identities = 17/68 (25%), Positives = 29/68 (42%), Gaps = 2/68 (2%)
Query: 16 WNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIV-TCGADR 74
WN+ + ++ +V I+ K + L H I G+DW P S+ I+ T D
Sbjct: 156 WNKKNANCLATSHDGDVRIWDKRKPSTAVEY-LAAHLSKIHGLDWHPDSEHILATSSQDN 214
Query: 75 NAYVWSQK 82
+ W +
Sbjct: 215 SVKFWDYR 222
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 42.7 bits (99), Expect = 5e-04
Identities = 56/227 (24%), Positives = 89/227 (39%), Gaps = 28/227 (12%)
Query: 48 LKEHNGHITGIDWAPKSDRI-VTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSP 106
L +H + + +AP I V+ D+ VW KD + +LR ++ +
Sbjct: 20 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDD--GNMMKVLRGHQNWVYSCAFS 77
Query: 107 LENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKC 166
++ GA S F D + + V++ D+ P+ LLA S D +
Sbjct: 78 PDSSMLCSVGA---SKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRV 134
Query: 167 RVFSAYIKEVDEKPASTPWGSKMPFGQLMSE----FGGSGTGGWVHGVSFSASGSRLAWV 222
++ + ++ M FG L F G WV VSFS G +A +
Sbjct: 135 YIWDPHNGDI-----------LMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 183
Query: 223 SHDSTVSV--ADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAG-HD 266
+ D V D VQV+ L L +F ++ SV+AAG HD
Sbjct: 184 ADDKMVRFWRIDEDYPVQVAPLSNG----LCCAFSTDGSVLAAGTHD 226
>gi|55953102 tubby like protein 4 isoform 2 [Homo sapiens]
Length = 678
Score = 42.0 bits (97), Expect = 9e-04
Identities = 49/230 (21%), Positives = 84/230 (36%), Gaps = 33/230 (14%)
Query: 48 LKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPL 107
L+ HN + + W ++ TC AD +VW Q +G W LV R + + F WS
Sbjct: 78 LRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFT-WSHD 136
Query: 108 ENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCR 167
+ + + V + W +++ I + W P++ + G+ D +
Sbjct: 137 GTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGI----WTPDDQQVLFGTADGQVI 192
Query: 168 VFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHD-S 226
V + +M L+ E G W + + S S D +
Sbjct: 193 VMDCH--------------GRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYA 238
Query: 227 TVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDD 276
A+ + V +K PLL+VSF S + ++ NYDD
Sbjct: 239 PPQDGPAAYPIPVQNIK----PLLTVSFTSGD---------ISLMNNYDD 275
>gi|55953100 tubby like protein 4 isoform 1 [Homo sapiens]
Length = 1543
Score = 42.0 bits (97), Expect = 9e-04
Identities = 49/230 (21%), Positives = 84/230 (36%), Gaps = 33/230 (14%)
Query: 48 LKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPL 107
L+ HN + + W ++ TC AD +VW Q +G W LV R + + F WS
Sbjct: 78 LRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFT-WSHD 136
Query: 108 ENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCR 167
+ + + V + W +++ I + W P++ + G+ D +
Sbjct: 137 GTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGI----WTPDDQQVLFGTADGQVI 192
Query: 168 VFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHD-S 226
V + +M L+ E G W + + S S D +
Sbjct: 193 VMDCH--------------GRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYA 238
Query: 227 TVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDD 276
A+ + V +K PLL+VSF S + ++ NYDD
Sbjct: 239 PPQDGPAAYPIPVQNIK----PLLTVSFTSGD---------ISLMNNYDD 275
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 41.6 bits (96), Expect = 0.001
Identities = 59/267 (22%), Positives = 110/267 (41%), Gaps = 37/267 (13%)
Query: 20 RTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVW 79
+ Q+ALS + ++ +N + +K L H ++ + ++P + + + ADR +W
Sbjct: 10 KAQLALSSSANQSKEVPENPNYALKC-TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
Query: 80 SQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWV--SKHI 137
DG ++ TL N + V WS +RL+S ++ W V K +
Sbjct: 69 GAYDGKYEKTL--YGHNLEISDVAWS--------SDSSRLVSASDDKTLKLWDVRSGKCL 118
Query: 138 K--KPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLM 195
K K + V +++P + L+ +GS D +++ ++ G+ +
Sbjct: 119 KTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW------------------EVKTGKCL 160
Query: 196 SEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFV 255
S V V F+ SGS + S+D + DA+ + TL + P +S
Sbjct: 161 KTL--SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF 218
Query: 256 SENS--VVAAGHDCCPMLFNYDDRGCL 280
S N ++ A D L++Y CL
Sbjct: 219 SPNGKYILTATLDNTLKLWDYSRGRCL 245
Score = 32.7 bits (73), Expect = 0.54
Identities = 46/217 (21%), Positives = 81/217 (37%), Gaps = 25/217 (11%)
Query: 145 VLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTG 204
V S+ + PN LA+ S D ++ AY D K T +G +
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAY----DGKYEKTLYGHNLE-------------- 85
Query: 205 GWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSF-VSENSVVAA 263
+ V++S+ SRL S D T+ + D + TLK + +F N +++
Sbjct: 86 --ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISG 143
Query: 264 GHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMS-AMERFRNMDKRATTED--RNTALE 320
D ++ CL +S P ++ N S ++ + D D L+
Sbjct: 144 SFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 321 TLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDF 357
TL + VS + + T +D + +WD+
Sbjct: 204 TLVDDDNPPVSFVKFSPNG-KYILTATLDNTLKLWDY 239
Score = 31.6 bits (70), Expect = 1.2
Identities = 16/76 (21%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Query: 15 AWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADR 74
AW+ D +++ + ++ + ++ + +K LK H+ ++ ++ P S+ I++ D
Sbjct: 90 AWSSDSSRLVSASDDKTLKLWDVRSGKCLKT--LKGHSNYVFCCNFNPPSNLIISGSFDE 147
Query: 75 NAYVWSQKDGVWKPTL 90
+W K G TL
Sbjct: 148 TVKIWEVKTGKCLKTL 163
>gi|118402582 cell division cycle 20 [Homo sapiens]
Length = 499
Score = 40.4 bits (93), Expect = 0.003
Identities = 33/162 (20%), Positives = 65/162 (40%), Gaps = 10/162 (6%)
Query: 16 WNRDRTQIALSPNNHEVHIYKKNGSQ--WVKAHELKEHNGHITGIDWAPKSDRIVTCG-- 71
W D +A N++ V+++ + WV +H G + + W P ++ G
Sbjct: 317 WAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGG 376
Query: 72 -ADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESEND 130
+DR+ +W+ G L + + + WSP + G G + ++
Sbjct: 377 TSDRHIRIWNVCSGA---CLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTM 433
Query: 131 WWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAY 172
V++ K S VLSL P+ +A+ + D R++ +
Sbjct: 434 AKVAE--LKGHTSRVLSLTMSPDGATVASAAADETLRLWRCF 473
Score = 37.4 bits (85), Expect = 0.022
Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 8/84 (9%)
Query: 48 LKEHNGHITGIDWAPKSDRIVTCGADRNAYVW--SQKDGVWKPTLVILRINRAATFVKWS 105
L H+ + G+ WAP + + G D VW + +G W P + A V W
Sbjct: 305 LSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWC 364
Query: 106 PLE-NKFAVGSGA-----RLISVC 123
P + N A G G R+ +VC
Sbjct: 365 PWQSNVLATGGGTSDRHIRIWNVC 388
>gi|21536485 HIR histone cell cycle regulation defective homolog A
[Homo sapiens]
Length = 1017
Score = 40.4 bits (93), Expect = 0.003
Identities = 34/174 (19%), Positives = 63/174 (36%), Gaps = 32/174 (18%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKK-----------------NGSQWVKAHELKEHNG 53
+ C W+ +A ++ + ++K+ N QW L+ H+G
Sbjct: 73 VNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRNHSG 132
Query: 54 HITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVK---WSPLENK 110
+ + W+P + +C D +W+ K ++ + + VK W P+
Sbjct: 133 DVMDVAWSPHDAWLASCSVDNTVVIWN----AVKFPEILATLRGHSGLVKGLTWDPVGKY 188
Query: 111 FAVGSGARLISVCYFESENDWWVSKHIKKPI-----RSTVLSLDWHPNNVLLAA 159
A + R + V DW + I KP + VL L W P+ L +
Sbjct: 189 IASQADDRSLKVW---RTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVS 239
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 40.4 bits (93), Expect = 0.003
Identities = 52/244 (21%), Positives = 93/244 (38%), Gaps = 39/244 (15%)
Query: 44 KAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVK 103
K E K H + +D++ + T D++ VWS + +L R K
Sbjct: 94 KFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLY--RHTHWVRCAK 151
Query: 104 WSPLENKFAVGSGARLISVCYFESENDWW--VSKHIKKPIRSTV---LSLDWHPNNVLLA 158
+SP RLI C + W +K +V +D++P+ +A
Sbjct: 152 FSP---------DGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIA 202
Query: 159 AGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSR 218
+ D +V+ + ++ + Q+ S G V+ +SF SG+
Sbjct: 203 SAGSDQTVKVWDVRVNKL------------LQHYQVHS--------GGVNCISFHPSGNY 242
Query: 219 LAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLF---NYD 275
L S D T+ + D + + TL+ P+ +VSF + A+G +L N+D
Sbjct: 243 LITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302
Query: 276 DRGC 279
+ C
Sbjct: 303 ELHC 306
Score = 35.4 bits (80), Expect = 0.083
Identities = 43/189 (22%), Positives = 69/189 (36%), Gaps = 32/189 (16%)
Query: 49 KEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRI---NRAATFVKWS 105
K H IT +D +P ++ T D +W+ +KP R T V++S
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----FKPHARAYRYVGHKDVVTSVQFS 69
Query: 106 PLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFK 165
P N A S R + + + + K P+R S+D+ + LA S D
Sbjct: 70 PHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVR----SVDFSADGQFLATASEDKS 125
Query: 166 CRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHD 225
+V+S Y + L S + + WV FS G + S D
Sbjct: 126 IKVWSMYRQRF-----------------LYSLYRHT---HWVRCAKFSPDGRLIVSCSED 165
Query: 226 STVSVADAS 234
T+ + D +
Sbjct: 166 KTIKIWDTT 174
>gi|30089954 H326 [Homo sapiens]
Length = 597
Score = 40.0 bits (92), Expect = 0.003
Identities = 18/75 (24%), Positives = 45/75 (60%), Gaps = 4/75 (5%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYKKN---GSQWVKAHELKEHNGHITGID-WAPKSDR 66
ITC ++ D T++ S N+ +++++ + G+Q+VK ++ +N + G++ + PKS+
Sbjct: 390 ITCLVYSHDGTELLASYNDEDIYLFNSSHSDGAQYVKRYKGHRNNATVKGVNFYGPKSEF 449
Query: 67 IVTCGADRNAYVWSQ 81
+V+ + ++W +
Sbjct: 450 VVSGSDCGHIFLWEK 464
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 39.7 bits (91), Expect = 0.004
Identities = 52/233 (22%), Positives = 90/233 (38%), Gaps = 49/233 (21%)
Query: 45 AHELK---EHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATF 101
A ELK H+G + G ++P + +++ D +WS + T L + +
Sbjct: 533 ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQ------TFTCLVGYKGHNY 586
Query: 102 VKW----SPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIR------STVLSLDWH 151
W SP F G R+ + W + H + P+R + V +H
Sbjct: 587 PVWDTQFSPYGYYFVSGGHDRVARL---------WATDHYQ-PLRIFAGHLADVNCTRFH 636
Query: 152 PNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVS 211
PN+ +A GS D R++ G + F +G G +H ++
Sbjct: 637 PNSNYVATGSADRTVRLWDVLN------------------GNCVRIF--TGHKGPIHSLT 676
Query: 212 FSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAG 264
FS +G LA + D V + D + V LK + S+ F + ++A+G
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASG 729
>gi|7549793 transducin (beta)-like 2 [Homo sapiens]
Length = 447
Score = 39.7 bits (91), Expect = 0.004
Identities = 57/230 (24%), Positives = 85/230 (36%), Gaps = 47/230 (20%)
Query: 45 AHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRIN---RAATF 101
A LK H+G+I+ +D++ + TC DR +WS KD + + +R N AT
Sbjct: 83 AAALKSHSGNISCMDFSSNGKYLATCADDRTIRIWSTKDFLQREHR-SMRANVELDHATL 141
Query: 102 VKWSPLENKFAV----GSGARLISVC-------YFESENDWWVSKHIKKPI--------- 141
V++SP F V G R+ + F + + + KH K P+
Sbjct: 142 VRFSPDCRAFIVWLANGDTLRVFKMTKREDGGYTFTATPEDFPKKH-KAPVIDIGIANTG 200
Query: 142 ------RSTVLSLDW-------------HPNNVLLAAGSCDFKCRVFSAYIKEVDEKPAS 182
S L W NN A C R ++ D K
Sbjct: 201 KFIMTASSDTTVLIWSLKGQVLSTINTNQMNNTHAAVSPCG---RFVASCGFTPDVKVWE 257
Query: 183 TPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVAD 232
+G K F +++ F G VH +FS R+A VS D T + D
Sbjct: 258 VCFGKKGEFQEVVRAFELKGHSAAVHSFAFSNDSRRMASVSKDGTWKLWD 307
>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
sapiens]
Length = 474
Score = 39.7 bits (91), Expect = 0.004
Identities = 25/132 (18%), Positives = 54/132 (40%), Gaps = 8/132 (6%)
Query: 51 HNGHITGIDWAPKSDRIVTCGA-DRNAYVWSQKD-----GVWKPTLVILRINRAATFVKW 104
H G + IDW P +D+++ G+ D VW + + +P +++ ++ V W
Sbjct: 79 HTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAW 138
Query: 105 SPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDF 164
P + +G + + + + ++ + ++ W+ N L+ S D
Sbjct: 139 HPTARNVLLSAGCDNAIIIWNVGTGEALI--NLDDMHSDMIYNVSWNRNGSLICTASKDK 196
Query: 165 KCRVFSAYIKEV 176
K RV +E+
Sbjct: 197 KVRVIDPRKQEI 208
>gi|53729352 WD repeat-containing protein 1 isoform 2 [Homo sapiens]
Length = 466
Score = 38.1 bits (87), Expect = 0.013
Identities = 17/70 (24%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYK-KNGSQWVKAHELKEHNGHITGIDWAPKSDRIVT 69
+ C ++ D + A + + +++IY K G + K H+G I I W+P S +++
Sbjct: 52 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 111
Query: 70 CGADRNAYVW 79
D+ + +W
Sbjct: 112 ASGDKTSKIW 121
Score = 30.4 bits (67), Expect = 2.7
Identities = 16/74 (21%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 10 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVT 69
P+T A++ D +A+ + V ++ + + + H+ I + W+P ++ +
Sbjct: 351 PVTDVAYSHDGAFLAVCDASKVVTVFSV-ADGYSENNVFYGHHAKIVCLAWSPDNEHFAS 409
Query: 70 CGADRNAYVWSQKD 83
G D YVW+ D
Sbjct: 410 GGMDMMVYVWTLSD 423
Score = 29.3 bits (64), Expect = 5.9
Identities = 28/112 (25%), Positives = 45/112 (40%), Gaps = 9/112 (8%)
Query: 62 PKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI- 120
P D + G D N ++S K +L T V +S AV ++++
Sbjct: 315 PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVT 374
Query: 121 --SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFS 170
SV SEN+ + H K ++ L W P+N A+G D V++
Sbjct: 375 VFSVADGYSENNVFYGHHAK------IVCLAWSPDNEHFASGGMDMMVYVWT 420
>gi|9257257 WD repeat-containing protein 1 isoform 1 [Homo sapiens]
Length = 606
Score = 38.1 bits (87), Expect = 0.013
Identities = 17/70 (24%), Positives = 35/70 (50%), Gaps = 1/70 (1%)
Query: 11 ITCHAWNRDRTQIALSPNNHEVHIYK-KNGSQWVKAHELKEHNGHITGIDWAPKSDRIVT 69
+ C ++ D + A + + +++IY K G + K H+G I I W+P S +++
Sbjct: 192 VNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLS 251
Query: 70 CGADRNAYVW 79
D+ + +W
Sbjct: 252 ASGDKTSKIW 261
Score = 30.4 bits (67), Expect = 2.7
Identities = 16/74 (21%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 10 PITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVT 69
P+T A++ D +A+ + V ++ + + + H+ I + W+P ++ +
Sbjct: 491 PVTDVAYSHDGAFLAVCDASKVVTVFSV-ADGYSENNVFYGHHAKIVCLAWSPDNEHFAS 549
Query: 70 CGADRNAYVWSQKD 83
G D YVW+ D
Sbjct: 550 GGMDMMVYVWTLSD 563
Score = 29.3 bits (64), Expect = 5.9
Identities = 28/112 (25%), Positives = 45/112 (40%), Gaps = 9/112 (8%)
Query: 62 PKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLI- 120
P D + G D N ++S K +L T V +S AV ++++
Sbjct: 455 PGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVT 514
Query: 121 --SVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFS 170
SV SEN+ + H K ++ L W P+N A+G D V++
Sbjct: 515 VFSVADGYSENNVFYGHHAK------IVCLAWSPDNEHFASGGMDMMVYVWT 560
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.132 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,499,220
Number of Sequences: 37866
Number of extensions: 564385
Number of successful extensions: 1918
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 75
Number of HSP's that attempted gapping in prelim test: 1519
Number of HSP's gapped (non-prelim): 414
length of query: 370
length of database: 18,247,518
effective HSP length: 104
effective length of query: 266
effective length of database: 14,309,454
effective search space: 3806314764
effective search space used: 3806314764
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.