Guide to the Human Genome
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Search of human proteins with 228480205

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|228480205 four and a half LIM domains 1 isoform 5 [Homo
sapiens]
         (296 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]   669   0.0  
gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]   655   0.0  
gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]   636   0.0  
gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]   636   0.0  
gi|21361122 four and a half LIM domains 1 isoform 2 [Homo sapiens]    636   0.0  
gi|228480211 four and a half LIM domains 1 isoform 1 [Homo sapiens]   525   e-149
gi|228480221 four and a half LIM domains 1 isoform 4 [Homo sapiens]   387   e-108
gi|87159836 four and a half LIM domains 2 [Homo sapiens]              335   2e-92
gi|87159834 four and a half LIM domains 2 [Homo sapiens]              335   2e-92
gi|42403575 four and a half LIM domains 2 [Homo sapiens]              335   2e-92
gi|87159832 four and a half LIM domains 2 [Homo sapiens]              335   2e-92
gi|54112385 four and a half LIM domains 3 [Homo sapiens]              297   7e-81
gi|30410801 activator of cAMP-responsive element modulator (CREM...   290   8e-79
gi|170932518 paxillin isoform 3 [Homo sapiens]                        120   1e-27
gi|170932516 paxillin isoform 2 [Homo sapiens]                        120   1e-27
gi|170932514 paxillin isoform 1 [Homo sapiens]                        120   1e-27
gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo ...   120   2e-27
gi|238859658 LIM and senescent cell antigen-like domains 2 isofo...   119   4e-27
gi|238776788 LIM and senescent cell antigen-like domains 2 isofo...   119   4e-27
gi|238776786 LIM and senescent cell antigen-like domains 2 isofo...   119   4e-27
gi|40804748 LIM and senescent cell antigen-like domains 2 isofor...   119   4e-27
gi|221316659 leupaxin isoform 1 [Homo sapiens]                        117   9e-27
gi|4758670 leupaxin isoform 2 [Homo sapiens]                          117   9e-27
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]            112   5e-25
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]             112   5e-25
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]             109   3e-24
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]             109   3e-24
gi|109638745 transforming growth factor beta 1 induced transcrip...   105   5e-23
gi|21361591 transforming growth factor beta 1 induced transcript...   105   5e-23
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]            104   8e-23

>gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]
          Length = 296

 Score =  669 bits (1727), Expect = 0.0
 Identities = 296/296 (100%), Positives = 296/296 (100%)

Query: 1   MASHRHSGPSSYKVGTMAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECR 60
           MASHRHSGPSSYKVGTMAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECR
Sbjct: 1   MASHRHSGPSSYKVGTMAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECR 60

Query: 61  KPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGC 120
           KPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGC
Sbjct: 61  KPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGC 120

Query: 121 FKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVK 180
           FKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVK
Sbjct: 121 FKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVK 180

Query: 181 CNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGC 240
           CNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGC
Sbjct: 181 CNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGC 240

Query: 241 KNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           KNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL
Sbjct: 241 KNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296


>gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]
          Length = 309

 Score =  655 bits (1690), Expect = 0.0
 Identities = 289/290 (99%), Positives = 290/290 (100%)

Query: 7   SGPSSYKVGTMAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGAD 66
           +GPSSYKVGTMAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGAD
Sbjct: 20  AGPSSYKVGTMAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGAD 79

Query: 67  SKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVA 126
           SKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVA
Sbjct: 80  SKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVA 139

Query: 127 GDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAIT 186
           GDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAIT
Sbjct: 140 GDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAIT 199

Query: 187 SGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITG 246
           SGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITG
Sbjct: 200 SGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITG 259

Query: 247 FGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           FGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL
Sbjct: 260 FGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 309


>gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  636 bits (1641), Expect = 0.0
 Identities = 280/280 (100%), Positives = 280/280 (100%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF
Sbjct: 1   MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT
Sbjct: 61  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
           VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY
Sbjct: 181 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 240

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL
Sbjct: 241 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 280


>gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  636 bits (1641), Expect = 0.0
 Identities = 280/280 (100%), Positives = 280/280 (100%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF
Sbjct: 1   MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT
Sbjct: 61  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
           VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY
Sbjct: 181 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 240

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL
Sbjct: 241 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 280


>gi|21361122 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  636 bits (1641), Expect = 0.0
 Identities = 280/280 (100%), Positives = 280/280 (100%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF
Sbjct: 1   MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT
Sbjct: 61  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
           VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY
Sbjct: 181 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 240

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL
Sbjct: 241 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 280


>gi|228480211 four and a half LIM domains 1 isoform 1 [Homo sapiens]
          Length = 323

 Score =  525 bits (1351), Expect = e-149
 Identities = 230/230 (100%), Positives = 230/230 (100%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF
Sbjct: 1   MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT
Sbjct: 61  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
           VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITG 246
           WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITG
Sbjct: 181 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITG 230



 Score =  150 bits (380), Expect = 1e-36
 Identities = 74/215 (34%), Positives = 98/215 (45%), Gaps = 7/215 (3%)

Query: 82  FRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKD 141
           F C  C  PL  + +V KD    C KC  +  +  C  C K I A  + V YK   WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 142 CFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSG--GITYQDQPWHA 199
           CF C+ C   +   +F  K     C  C   + +  C  C KAI +G   + Y+   WH 
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHK 124

Query: 200 DCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQ 259
           DCF C  C + +    F    + +YCV C++   AK C  C   IT  G     + Y+ Q
Sbjct: 125 DCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG-----ITYQDQ 179

Query: 260 SWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAK 294
            WH  CF C  CS  LA +RF   ++Q YC DC K
Sbjct: 180 PWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYK 214



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 3/97 (3%)

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEG 258
           A+ F C  C   L G+++   +  + C+ C+  F A  C  C+ PI   G  S  V Y+ 
Sbjct: 2   AEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPI---GADSKEVHYKN 58

Query: 259 QSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
           + WHD CF C KC   LAN+ FV    ++ C  C  +
Sbjct: 59  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTR 95


>gi|228480221 four and a half LIM domains 1 isoform 4 [Homo sapiens]
          Length = 194

 Score =  387 bits (994), Expect = e-108
 Identities = 169/182 (92%), Positives = 173/182 (95%), Gaps = 2/182 (1%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF
Sbjct: 1   MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT
Sbjct: 61  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY--QD 194
           VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNK +    + +  +D
Sbjct: 121 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKGLVKAPVWWPMKD 180

Query: 195 QP 196
            P
Sbjct: 181 NP 182



 Score =  109 bits (272), Expect = 3e-24
 Identities = 52/161 (32%), Positives = 71/161 (44%), Gaps = 2/161 (1%)

Query: 82  FRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKD 141
           F C  C  PL  + +V KD    C KC  +  +  C  C K I A  + V YK   WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 142 CFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSG--GITYQDQPWHA 199
           CF C+ C   +   +F  K     C  C   + +  C  C KAI +G   + Y+   WH 
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHK 124

Query: 200 DCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGC 240
           DCF C  C + +    F    + +YCV C++   AK C  C
Sbjct: 125 DCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKC 165



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 46/152 (30%), Positives = 63/152 (41%), Gaps = 5/152 (3%)

Query: 143 FTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAI--TSGGITYQDQPWHAD 200
           F C  C+  +    +  K     C+ C +   A  CV+C K I   S  + Y+++ WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 201 CFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQS 260
           CF C  C   LA + F A +++  C  C     + KC GC   I     G   V Y+G  
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVA---GDQNVEYKGTV 121

Query: 261 WHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 292
           WH  CF C  C   +    F    E  YC  C
Sbjct: 122 WHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTC 153



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 3/97 (3%)

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEG 258
           A+ F C  C   L G+++   +  + C+ C+  F A  C  C+ PI   G  S  V Y+ 
Sbjct: 2   AEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPI---GADSKEVHYKN 58

Query: 259 QSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
           + WHD CF C KC   LAN+ FV    ++ C  C  +
Sbjct: 59  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTR 95


>gi|87159836 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  335 bits (860), Expect = 2e-92
 Identities = 135/280 (48%), Positives = 196/280 (70%), Gaps = 1/280 (0%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           M E+FDCH+C + L GKKY+ ++    C+ CF+   ANTC EC KPIG D K++ YK+R 
Sbjct: 1   MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRH 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WH+ CF C++C + L ++ F AK++++LC  C + E S KC+ C K I+ G + +EYKG+
Sbjct: 61  WHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
            WH+ CF C  C+Q IGT SF PK    +CV C+E + A  CV+C K IT+GG+TY++QP
Sbjct: 121 SWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WH +CFVC  C K+L+GQRFTA +D  YC++C+ +  AKKCAGC NPI+G G G+  +++
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLG-GTKYISF 239

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           E + WH+ CF+CKKCS++L  + F+  ++ + CPDC K +
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI 279


>gi|87159834 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  335 bits (860), Expect = 2e-92
 Identities = 135/280 (48%), Positives = 196/280 (70%), Gaps = 1/280 (0%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           M E+FDCH+C + L GKKY+ ++    C+ CF+   ANTC EC KPIG D K++ YK+R 
Sbjct: 1   MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRH 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WH+ CF C++C + L ++ F AK++++LC  C + E S KC+ C K I+ G + +EYKG+
Sbjct: 61  WHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
            WH+ CF C  C+Q IGT SF PK    +CV C+E + A  CV+C K IT+GG+TY++QP
Sbjct: 121 SWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WH +CFVC  C K+L+GQRFTA +D  YC++C+ +  AKKCAGC NPI+G G G+  +++
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLG-GTKYISF 239

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           E + WH+ CF+CKKCS++L  + F+  ++ + CPDC K +
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI 279


>gi|42403575 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  335 bits (860), Expect = 2e-92
 Identities = 135/280 (48%), Positives = 196/280 (70%), Gaps = 1/280 (0%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           M E+FDCH+C + L GKKY+ ++    C+ CF+   ANTC EC KPIG D K++ YK+R 
Sbjct: 1   MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRH 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WH+ CF C++C + L ++ F AK++++LC  C + E S KC+ C K I+ G + +EYKG+
Sbjct: 61  WHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
            WH+ CF C  C+Q IGT SF PK    +CV C+E + A  CV+C K IT+GG+TY++QP
Sbjct: 121 SWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WH +CFVC  C K+L+GQRFTA +D  YC++C+ +  AKKCAGC NPI+G G G+  +++
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLG-GTKYISF 239

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           E + WH+ CF+CKKCS++L  + F+  ++ + CPDC K +
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI 279


>gi|87159832 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  335 bits (860), Expect = 2e-92
 Identities = 135/280 (48%), Positives = 196/280 (70%), Gaps = 1/280 (0%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           M E+FDCH+C + L GKKY+ ++    C+ CF+   ANTC EC KPIG D K++ YK+R 
Sbjct: 1   MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRH 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WH+ CF C++C + L ++ F AK++++LC  C + E S KC+ C K I+ G + +EYKG+
Sbjct: 61  WHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
            WH+ CF C  C+Q IGT SF PK    +CV C+E + A  CV+C K IT+GG+TY++QP
Sbjct: 121 SWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WH +CFVC  C K+L+GQRFTA +D  YC++C+ +  AKKCAGC NPI+G G G+  +++
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLG-GTKYISF 239

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
           E + WH+ CF+CKKCS++L  + F+  ++ + CPDC K +
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI 279


>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
          Length = 280

 Score =  297 bits (761), Expect = 7e-81
 Identities = 123/278 (44%), Positives = 175/278 (62%), Gaps = 1/278 (0%)

Query: 17  MAEKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRF 76
           M+E FDC  C + L G+KY+Q D    C+ C+D   ANTC EC++ IG DS+E+ Y++R 
Sbjct: 1   MSESFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRH 60

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           +H+ CFRC +C   LA+E F  +D+++LCN C     S +C  C + ++ G + +EY G 
Sbjct: 61  FHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQ 120

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQP 196
            WH+ CF CS C+Q +G+ SF P     YCV C+E KFA  C +C+K +T GG+TY+DQP
Sbjct: 121 TWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGGVTYRDQP 180

Query: 197 WHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAY 256
           WH +C VC  C   LAGQ+FT+ ++  YCV C+    A KC+ CK PI G G G   V++
Sbjct: 181 WHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPKCSSCKRPIVGLG-GGKYVSF 239

Query: 257 EGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAK 294
           E + WH  CF C +CS +L  + FV   +QV C  C++
Sbjct: 240 EDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQGCSQ 277



 Score =  129 bits (323), Expect = 4e-30
 Identities = 63/217 (29%), Positives = 95/217 (43%), Gaps = 7/217 (3%)

Query: 82  FRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKD 141
           F CAKC   L    ++  D+   C  C     +  C  C + I    + + Y+   +H+ 
Sbjct: 5   FDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFHEG 64

Query: 142 CFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITYQDQPWHA 199
           CF C  C++ +    F  +  +  C  C+ + F+  C  C + +  G   + Y  Q WH 
Sbjct: 65  CFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTWHE 124

Query: 200 DCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQ 259
            CF+C  C + L  + F   +  +YCV CY+N  A +CA C   +T  G     V Y  Q
Sbjct: 125 HCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKTLTQGG-----VTYRDQ 179

Query: 260 SWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
            WH  C  C  C   LA ++F    E  YC  C  +L
Sbjct: 180 PWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGEL 216


>gi|30410801 activator of cAMP-responsive element modulator (CREM)
           in testis [Homo sapiens]
          Length = 284

 Score =  290 bits (743), Expect = 8e-79
 Identities = 121/272 (44%), Positives = 168/272 (61%), Gaps = 1/272 (0%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C YC   L GKKYV KD    C+ C+D+  +N C EC+KPI +DSK++ YK+R WH+ 
Sbjct: 6   FYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEG 65

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHK 140
           CF+C KC H L  + F AKD ++LC +C + E S KC  C + I+ G + +E+KG  WH+
Sbjct: 66  CFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHE 125

Query: 141 DCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWHAD 200
            CF C NC+Q IGT     K    YCV C E +FA +C  C K ITSGGIT+ DQ WH +
Sbjct: 126 TCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGGITFCDQLWHKE 185

Query: 201 CFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQS 260
           CF+C  C K L  ++F + +D  +C+DCY +  A KC  C  PI+G   G+  + ++   
Sbjct: 186 CFLCSGCRKDLCEEQFMSRDDYPFCMDCYNHLYANKCVACSKPISGL-TGAKFICFQDSQ 244

Query: 261 WHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 292
           WH  CF+C KCSV+L  K F+   ++++C  C
Sbjct: 245 WHSECFNCGKCSVSLVGKGFLTQNKEIFCQKC 276



 Score =  130 bits (326), Expect = 2e-30
 Identities = 64/217 (29%), Positives = 96/217 (44%), Gaps = 7/217 (3%)

Query: 82  FRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKD 141
           F C  C   L  + +V KD+   C  C  R  S  C+ C K I +  +++ YK   WH+ 
Sbjct: 6   FYCQYCTASLLGKKYVLKDDSPYCVTCYDRVFSNYCEECKKPIESDSKDLCYKDRHWHEG 65

Query: 142 CFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITYQDQPWHA 199
           CF C+ C   +    F  K E   C  C+  + +  C  C + I  G   + ++   WH 
Sbjct: 66  CFKCTKCNHSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHE 125

Query: 200 DCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQ 259
            CFVC  C + +  +   + E   YCV C++   A  C  CK  IT  G     + +  Q
Sbjct: 126 TCFVCENCRQPIGTKPLISKESGNYCVPCFEKEFAHYCNFCKKVITSGG-----ITFCDQ 180

Query: 260 SWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKKL 296
            WH  CF C  C  +L  ++F+   +  +C DC   L
Sbjct: 181 LWHKECFLCSGCRKDLCEEQFMSRDDYPFCMDCYNHL 217



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 2/98 (2%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIG--ADSKEVHYKNRF 76
           E F C  CR  L  ++++ +D +  C+ C++   AN CV C KPI     +K + +++  
Sbjct: 185 ECFLCSGCRKDLCEEQFMSRDDYPFCMDCYNHLYANKCVACSKPISGLTGAKFICFQDSQ 244

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDS 114
           WH  CF C KC   L  + F+ ++ +I C KC +  D+
Sbjct: 245 WHSECFNCGKCSVSLVGKGFLTQNKEIFCQKCGSGMDT 282


>gi|170932518 paxillin isoform 3 [Homo sapiens]
          Length = 424

 Score =  120 bits (302), Expect = 1e-27
 Identities = 67/211 (31%), Positives = 95/211 (45%), Gaps = 4/211 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C +C++ +  + + ++DG   C K +    +  C  C  PI    K V   +R WH
Sbjct: 213 EHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPI--LDKVVTALDRTWH 270

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
              F CA+C      E F  KD K  C K      +PKC GC +AI+  +  +    T+W
Sbjct: 271 PEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAIL--ENYISALNTLW 328

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWH 198
           H +CF C  C      GSFF      YC   +  +    C  C K IT   IT   + +H
Sbjct: 329 HPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFH 388

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
            + FVC  C K+L    F    D+ YC +C+
Sbjct: 389 PEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF 419



 Score =  111 bits (277), Expect = 9e-25
 Identities = 69/241 (28%), Positives = 95/241 (39%), Gaps = 9/241 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C  C+KPI    + V    + WH   F C  C   + +  F  +D +  C K      SP
Sbjct: 191 CGACKKPIAG--QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSP 248

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
           +C  C   I+  D+ V      WH + F C+ C    G   F  K    YC   +   FA
Sbjct: 249 RCYYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 306

Query: 176 KHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAK 235
             C  C +AI    I+  +  WH +CFVC  C        F   + Q YC   Y      
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366

Query: 236 KCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
            C+GC+ PITG       +    + +H   F C  C   L    F    ++ YC +C  K
Sbjct: 367 LCSGCQKPITG-----RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 421

Query: 296 L 296
           L
Sbjct: 422 L 422



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 28/113 (24%), Positives = 38/113 (33%), Gaps = 31/113 (27%)

Query: 203 VCVTCSKKLAGQRFTAV--------------------------EDQYYCVDCYKNFVAKK 236
           VC  C K +AGQ  TA+                          + Q YC   Y N  + +
Sbjct: 190 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 249

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           C  C  PI        VV    ++WH   F C +C      + F     + YC
Sbjct: 250 CYYCNGPIL-----DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC 297


>gi|170932516 paxillin isoform 2 [Homo sapiens]
          Length = 557

 Score =  120 bits (302), Expect = 1e-27
 Identities = 67/211 (31%), Positives = 95/211 (45%), Gaps = 4/211 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C +C++ +  + + ++DG   C K +    +  C  C  PI    K V   +R WH
Sbjct: 346 EHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPI--LDKVVTALDRTWH 403

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
              F CA+C      E F  KD K  C K      +PKC GC +AI+  +  +    T+W
Sbjct: 404 PEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAIL--ENYISALNTLW 461

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWH 198
           H +CF C  C      GSFF      YC   +  +    C  C K IT   IT   + +H
Sbjct: 462 HPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFH 521

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
            + FVC  C K+L    F    D+ YC +C+
Sbjct: 522 PEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF 552



 Score =  111 bits (277), Expect = 9e-25
 Identities = 69/241 (28%), Positives = 95/241 (39%), Gaps = 9/241 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C  C+KPI    + V    + WH   F C  C   + +  F  +D +  C K      SP
Sbjct: 324 CGACKKPIAG--QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSP 381

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
           +C  C   I+  D+ V      WH + F C+ C    G   F  K    YC   +   FA
Sbjct: 382 RCYYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 439

Query: 176 KHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAK 235
             C  C +AI    I+  +  WH +CFVC  C        F   + Q YC   Y      
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499

Query: 236 KCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
            C+GC+ PITG       +    + +H   F C  C   L    F    ++ YC +C  K
Sbjct: 500 LCSGCQKPITG-----RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 554

Query: 296 L 296
           L
Sbjct: 555 L 555



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 28/113 (24%), Positives = 38/113 (33%), Gaps = 31/113 (27%)

Query: 203 VCVTCSKKLAGQRFTAV--------------------------EDQYYCVDCYKNFVAKK 236
           VC  C K +AGQ  TA+                          + Q YC   Y N  + +
Sbjct: 323 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 382

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           C  C  PI        VV    ++WH   F C +C      + F     + YC
Sbjct: 383 CYYCNGPIL-----DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC 430


>gi|170932514 paxillin isoform 1 [Homo sapiens]
          Length = 591

 Score =  120 bits (302), Expect = 1e-27
 Identities = 67/211 (31%), Positives = 95/211 (45%), Gaps = 4/211 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C +C++ +  + + ++DG   C K +    +  C  C  PI    K V   +R WH
Sbjct: 380 EHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPI--LDKVVTALDRTWH 437

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
              F CA+C      E F  KD K  C K      +PKC GC +AI+  +  +    T+W
Sbjct: 438 PEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAIL--ENYISALNTLW 495

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWH 198
           H +CF C  C      GSFF      YC   +  +    C  C K IT   IT   + +H
Sbjct: 496 HPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFH 555

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
            + FVC  C K+L    F    D+ YC +C+
Sbjct: 556 PEHFVCAFCLKQLNKGTFKEQNDKPYCQNCF 586



 Score =  111 bits (277), Expect = 9e-25
 Identities = 69/241 (28%), Positives = 95/241 (39%), Gaps = 9/241 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C  C+KPI    + V    + WH   F C  C   + +  F  +D +  C K      SP
Sbjct: 358 CGACKKPIAG--QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSP 415

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
           +C  C   I+  D+ V      WH + F C+ C    G   F  K    YC   +   FA
Sbjct: 416 RCYYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 473

Query: 176 KHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAK 235
             C  C +AI    I+  +  WH +CFVC  C        F   + Q YC   Y      
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533

Query: 236 KCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
            C+GC+ PITG       +    + +H   F C  C   L    F    ++ YC +C  K
Sbjct: 534 LCSGCQKPITG-----RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLK 588

Query: 296 L 296
           L
Sbjct: 589 L 589



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 28/113 (24%), Positives = 38/113 (33%), Gaps = 31/113 (27%)

Query: 203 VCVTCSKKLAGQRFTAV--------------------------EDQYYCVDCYKNFVAKK 236
           VC  C K +AGQ  TA+                          + Q YC   Y N  + +
Sbjct: 357 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 416

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           C  C  PI        VV    ++WH   F C +C      + F     + YC
Sbjct: 417 CYYCNGPIL-----DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYC 464


>gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo
           sapiens]
          Length = 325

 Score =  120 bits (300), Expect = 2e-27
 Identities = 79/282 (28%), Positives = 112/282 (39%), Gaps = 18/282 (6%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C        + + +G   C   F    A  C +C + I    + +   N  WH  
Sbjct: 36  FVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFI--IGRVIKAMNNSWHPE 93

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 134
           CFRC  C   LA+  FV    + LC  C  RE   K +G  K I      +  +Q + +K
Sbjct: 94  CFRCDLCQEVLADIGFVKNAGRHLCRPCHNRE---KARGLGKYICQKCHAIIDEQPLIFK 150

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194
              +H D F C+NC + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 151 NDPYHPDHFNCANCGKELTADARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNAMG 209

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254
           + WH + FVC  C K   G R    +   YC   Y       C  C   I G      VV
Sbjct: 210 KQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVCFHCNRVIEG-----DVV 264

Query: 255 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 295
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 265 SALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEK 306



 Score =  110 bits (275), Expect = 1e-24
 Identities = 61/240 (25%), Positives = 95/240 (39%), Gaps = 13/240 (5%)

Query: 55  TCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDS 114
           TC  C+       K V+     +H+ CF CA+C        F   + +  C        +
Sbjct: 9   TCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFA 68

Query: 115 PKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKF 174
           P C  C + I+   + ++     WH +CF C  C++V+    F        C  CH  + 
Sbjct: 69  PCCHQCGEFIIG--RVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREK 126

Query: 175 AKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
           A+      C KC+  I    + +++ P+H D F C  C K+L       ++ + YC+ C+
Sbjct: 127 ARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADA-RELKGELYCLPCH 185

Query: 230 KNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
                  C  C+ PI G      VV   G+ WH   F C KC       R    +   YC
Sbjct: 186 DKMGVPICGACRRPIEG-----RVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYC 240



 Score = 92.8 bits (229), Expect = 3e-19
 Identities = 62/221 (28%), Positives = 95/221 (42%), Gaps = 13/221 (5%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCAN-----TCVECRKPIGADSKEVHYK 73
           E F C  C++ L    +V+  G H C  C ++  A       C +C   I  D + + +K
Sbjct: 93  ECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAII--DEQPLIFK 150

Query: 74  NRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEY 133
           N  +H   F CA C   L  +    K  ++ C  C  +   P C  C + I    + V  
Sbjct: 151 NDPYHPDHFNCANCGKELTADARELK-GELYCLPCHDKMGVPICGACRRPIEG--RVVNA 207

Query: 134 KGTVWHKDCFTCSNC-KQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITY 192
            G  WH + F C+ C K  +G   +  KG   YC T +   F   C  CN+ I    ++ 
Sbjct: 208 MGKQWHVEHFVCAKCEKPFLGHRHYERKGL-AYCETHYNQLFGDVCFHCNRVIEGDVVSA 266

Query: 193 QDQPWHADCFVCVTCSKKLA-GQRFTAVEDQYYCVDCYKNF 232
            ++ W  +CF C TC+ KL    +F   + +  C  CY+ F
Sbjct: 267 LNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEKF 307



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 47/189 (24%), Positives = 76/189 (40%), Gaps = 13/189 (6%)

Query: 114 SPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETK 173
           S  C+ C       ++ V   G ++H+ CF C+ C Q    G F+      YC    +  
Sbjct: 7   SATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQML 66

Query: 174 FAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFV 233
           FA  C +C + I    I   +  WH +CF C  C + LA   F     ++ C  C+    
Sbjct: 67  FAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREK 126

Query: 234 AKK-----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNL-ANKRFVFHQEQV 287
           A+      C  C   I         + ++   +H   F+C  C   L A+ R +  + ++
Sbjct: 127 ARGLGKYICQKCHAII-----DEQPLIFKNDPYHPDHFNCANCGKELTADAREL--KGEL 179

Query: 288 YCPDCAKKL 296
           YC  C  K+
Sbjct: 180 YCLPCHDKM 188


>gi|238859658 LIM and senescent cell antigen-like domains 2 isoform
           1 [Homo sapiens]
          Length = 363

 Score =  119 bits (297), Expect = 4e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 63  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 120

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 134
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 121 CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 177

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 178 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 236

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 237 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 291

Query: 255 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 295
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 292 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 333



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 49  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 108
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 30  DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 89

Query: 109 TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 168
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 90  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 147

Query: 169 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 223
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 148 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 206

Query: 224 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 283
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 207 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 261

Query: 284 QEQVYC 289
           +   YC
Sbjct: 262 KGLAYC 267



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 117 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 176
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 37  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 96

Query: 177 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 97  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 156

Query: 237 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 291
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 157 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 210

Query: 292 CAKKL 296
           C  K+
Sbjct: 211 CHDKM 215


>gi|238776788 LIM and senescent cell antigen-like domains 2 isoform
           5 [Homo sapiens]
          Length = 336

 Score =  119 bits (297), Expect = 4e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 36  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 93

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 134
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 94  CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 150

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 151 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 209

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 210 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 264

Query: 255 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 295
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 265 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 306



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 49  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 108
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 3   DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 62

Query: 109 TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 168
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 63  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 120

Query: 169 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 223
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 121 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 179

Query: 224 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 283
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 180 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 234

Query: 284 QEQVYC 289
           +   YC
Sbjct: 235 KGLAYC 240



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 117 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 176
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 10  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 69

Query: 177 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 70  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 129

Query: 237 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 291
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 130 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 183

Query: 292 CAKKL 296
           C  K+
Sbjct: 184 CHDKM 188


>gi|238776786 LIM and senescent cell antigen-like domains 2 isoform
           3 [Homo sapiens]
          Length = 341

 Score =  119 bits (297), Expect = 4e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 41  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 98

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 134
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 99  CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 155

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 156 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 214

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 215 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 269

Query: 255 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 295
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 270 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 311



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 49  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 108
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 8   DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 67

Query: 109 TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 168
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 68  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 125

Query: 169 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 223
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 126 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 184

Query: 224 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 283
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 185 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 239

Query: 284 QEQVYC 289
           +   YC
Sbjct: 240 KGLAYC 245



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 117 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 176
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 15  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 74

Query: 177 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 75  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 134

Query: 237 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 291
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 135 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 188

Query: 292 CAKKL 296
           C  K+
Sbjct: 189 CHDKM 193


>gi|40804748 LIM and senescent cell antigen-like domains 2 isoform 2
           [Homo sapiens]
          Length = 365

 Score =  119 bits (297), Expect = 4e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 134
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 179

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 180 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 238

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 239 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 293

Query: 255 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 295
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 294 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 49  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 108
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 32  DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 91

Query: 109 TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 168
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 92  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149

Query: 169 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 223
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 208

Query: 224 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 283
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 209 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 263

Query: 284 QEQVYC 289
           +   YC
Sbjct: 264 KGLAYC 269



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 117 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 176
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98

Query: 177 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 99  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 158

Query: 237 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 291
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 159 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 212

Query: 292 CAKKL 296
           C  K+
Sbjct: 213 CHDKM 217


>gi|221316659 leupaxin isoform 1 [Homo sapiens]
          Length = 391

 Score =  117 bits (294), Expect = 9e-27
 Identities = 66/241 (27%), Positives = 99/241 (41%), Gaps = 9/241 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C  C+KPI    K +H   + WH   F C  C   + +  F  +     C     +  SP
Sbjct: 157 CASCQKPIAG--KVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSP 214

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
           +C  C   I+  D+ +      WH + F CS+C +V G   F  K +  YC       F+
Sbjct: 215 RCAYCAAPIL--DKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 272

Query: 176 KHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAK 235
             C  CN+ +    ++  D  WH +CFVC  C    +   F  ++ + +C   Y +    
Sbjct: 273 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 332

Query: 236 KCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
            C GC  PITG       ++  G  +H   F C  C   L+   F    ++ YC  C  K
Sbjct: 333 LCHGCGQPITG-----RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNK 387

Query: 296 L 296
           L
Sbjct: 388 L 388



 Score =  107 bits (267), Expect = 1e-23
 Identities = 60/211 (28%), Positives = 91/211 (43%), Gaps = 4/211 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C +C++ +    + ++ G   C   + +  +  C  C  PI    K +   N+ WH
Sbjct: 179 EHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPI--LDKVLTAMNQTWH 236

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
              F C+ C      E F  KD K  C K      SPKC GC + ++  +  +    TVW
Sbjct: 237 PEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVL--ENYLSAMDTVW 294

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWH 198
           H +CF C +C     TGSFF      +C   +  +    C  C + IT   I+     +H
Sbjct: 295 HPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFH 354

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
            + FVC  C  +L+   F    D+ YC  C+
Sbjct: 355 PEHFVCAFCLTQLSKGIFREQNDKTYCQPCF 385



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 32/113 (28%), Positives = 44/113 (38%), Gaps = 5/113 (4%)

Query: 177 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236
           HC  C K I    I    Q WH + FVC  C +++    F       YC + Y    + +
Sbjct: 156 HCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPR 215

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           CA C  PI        V+    Q+WH   F C  C      + F    ++ YC
Sbjct: 216 CAYCAAPIL-----DKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYC 263



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 36/156 (23%), Positives = 58/156 (37%), Gaps = 4/156 (2%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C +C +    + + +KD    C K F    +  C  C +P+  +       +  WH
Sbjct: 238 EHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSA--MDTVWH 295

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
             CF C  C    +  +F   D +  C           C GC + I    + +   G  +
Sbjct: 296 PECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITG--RCISAMGYKF 353

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKF 174
           H + F C+ C   +  G F  + +  YC  C    F
Sbjct: 354 HPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389


>gi|4758670 leupaxin isoform 2 [Homo sapiens]
          Length = 386

 Score =  117 bits (294), Expect = 9e-27
 Identities = 66/241 (27%), Positives = 99/241 (41%), Gaps = 9/241 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C  C+KPI    K +H   + WH   F C  C   + +  F  +     C     +  SP
Sbjct: 152 CASCQKPIAG--KVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSP 209

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
           +C  C   I+  D+ +      WH + F CS+C +V G   F  K +  YC       F+
Sbjct: 210 RCAYCAAPIL--DKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 267

Query: 176 KHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAK 235
             C  CN+ +    ++  D  WH +CFVC  C    +   F  ++ + +C   Y +    
Sbjct: 268 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 327

Query: 236 KCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
            C GC  PITG       ++  G  +H   F C  C   L+   F    ++ YC  C  K
Sbjct: 328 LCHGCGQPITG-----RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNK 382

Query: 296 L 296
           L
Sbjct: 383 L 383



 Score =  107 bits (267), Expect = 1e-23
 Identities = 60/211 (28%), Positives = 91/211 (43%), Gaps = 4/211 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C +C++ +    + ++ G   C   + +  +  C  C  PI    K +   N+ WH
Sbjct: 174 EHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPI--LDKVLTAMNQTWH 231

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
              F C+ C      E F  KD K  C K      SPKC GC + ++  +  +    TVW
Sbjct: 232 PEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVL--ENYLSAMDTVW 289

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWH 198
           H +CF C +C     TGSFF      +C   +  +    C  C + IT   I+     +H
Sbjct: 290 HPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFH 349

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
            + FVC  C  +L+   F    D+ YC  C+
Sbjct: 350 PEHFVCAFCLTQLSKGIFREQNDKTYCQPCF 380



 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 32/113 (28%), Positives = 44/113 (38%), Gaps = 5/113 (4%)

Query: 177 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236
           HC  C K I    I    Q WH + FVC  C +++    F       YC + Y    + +
Sbjct: 151 HCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPR 210

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           CA C  PI        V+    Q+WH   F C  C      + F    ++ YC
Sbjct: 211 CAYCAAPIL-----DKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYC 258



 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 36/156 (23%), Positives = 58/156 (37%), Gaps = 4/156 (2%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C +C +    + + +KD    C K F    +  C  C +P+  +       +  WH
Sbjct: 233 EHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSA--MDTVWH 290

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
             CF C  C    +  +F   D +  C           C GC + I    + +   G  +
Sbjct: 291 PECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITG--RCISAMGYKF 348

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKF 174
           H + F C+ C   +  G F  + +  YC  C    F
Sbjct: 349 HPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 384


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score =  112 bits (279), Expect = 5e-25
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194
           G  WH + FTC+ CK  +    F  +  + YC  C+E  FA  C KCN  I    +    
Sbjct: 457 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 516

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254
           Q WH  CFVC  C K      F   + + YC   Y N  + KC GC  P+     G   +
Sbjct: 517 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEA---GDKFI 573

Query: 255 AYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
              G +WHD CF C  C VNL  + F   +++  C
Sbjct: 574 EALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 608



 Score = 99.0 bits (245), Expect = 4e-21
 Identities = 48/148 (32%), Positives = 71/148 (47%), Gaps = 2/148 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E+F C YC+  L    +V++  +  C +C+++F A  C +C   I  +   +H   + WH
Sbjct: 463 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 520

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
            TCF CA C  P  N  F  +D +  C K      S KC GC   + AGD+ +E  G  W
Sbjct: 521 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 580

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 166
           H  CF C+ C   +    F+ K +   C
Sbjct: 581 HDTCFICAVCHVNLEGQPFYSKKDRPLC 608



 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 4/153 (2%)

Query: 75  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYK 134
           R WH   F CA C   LA+  FV + N + C +C  +  +P C  C   I+   + +   
Sbjct: 458 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG--EVMHAL 515

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITY 192
              WH  CF C+ CK+  G   F  +  + YC   +   F+  C  C+  + +G   I  
Sbjct: 516 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 575

Query: 193 QDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 225
               WH  CF+C  C   L GQ F + +D+  C
Sbjct: 576 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 608



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 5/112 (4%)

Query: 178 CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKC 237
           C  CN  I    +    + WH + F C  C   LA   F   ++  YC  CY+ F A  C
Sbjct: 441 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 500

Query: 238 AGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           A C   I G      V+    Q+WH  CF C  C     N  F     + YC
Sbjct: 501 AKCNTKIMG-----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYC 547



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 28/87 (32%), Positives = 39/87 (44%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C+ P     +  +DG   C K +    +  C  C  P+ A  K +      WHDT
Sbjct: 524 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 583

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNK 107
           CF CA C   L  + F +K ++ LC K
Sbjct: 584 CFICAVCHVNLEGQPFYSKKDRPLCKK 610



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 5/56 (8%)

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 292
           C  C N I    +G  +VA  G+SWH   F C  C  +LA+  FV  Q  VYC  C
Sbjct: 441 CGHCNNVI----RGPFLVAM-GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERC 491


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score =  112 bits (279), Expect = 5e-25
 Identities = 53/155 (34%), Positives = 70/155 (45%), Gaps = 3/155 (1%)

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194
           G  WH + FTC+ CK  +    F  +  + YC  C+E  FA  C KCN  I    +    
Sbjct: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254
           Q WH  CFVC  C K      F   + + YC   Y N  + KC GC  P+     G   +
Sbjct: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEA---GDKFI 683

Query: 255 AYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
              G +WHD CF C  C VNL  + F   +++  C
Sbjct: 684 EALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718



 Score = 99.0 bits (245), Expect = 4e-21
 Identities = 48/148 (32%), Positives = 71/148 (47%), Gaps = 2/148 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E+F C YC+  L    +V++  +  C +C+++F A  C +C   I  +   +H   + WH
Sbjct: 573 EEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEV--MHALRQTWH 630

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
            TCF CA C  P  N  F  +D +  C K      S KC GC   + AGD+ +E  G  W
Sbjct: 631 TTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTW 690

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 166
           H  CF C+ C   +    F+ K +   C
Sbjct: 691 HDTCFICAVCHVNLEGQPFYSKKDRPLC 718



 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 4/153 (2%)

Query: 75  RFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYK 134
           R WH   F CA C   LA+  FV + N + C +C  +  +P C  C   I+   + +   
Sbjct: 568 RSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMG--EVMHAL 625

Query: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGG--ITY 192
              WH  CF C+ CK+  G   F  +  + YC   +   F+  C  C+  + +G   I  
Sbjct: 626 RQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEA 685

Query: 193 QDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 225
               WH  CF+C  C   L GQ F + +D+  C
Sbjct: 686 LGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 718



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 35/112 (31%), Positives = 44/112 (39%), Gaps = 5/112 (4%)

Query: 178 CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKC 237
           C  CN  I    +    + WH + F C  C   LA   F   ++  YC  CY+ F A  C
Sbjct: 551 CGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLC 610

Query: 238 AGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           A C   I G      V+    Q+WH  CF C  C     N  F     + YC
Sbjct: 611 AKCNTKIMG-----EVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYC 657



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 28/87 (32%), Positives = 39/87 (44%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C+ P     +  +DG   C K +    +  C  C  P+ A  K +      WHDT
Sbjct: 634 FVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEALGHTWHDT 693

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNK 107
           CF CA C   L  + F +K ++ LC K
Sbjct: 694 CFICAVCHVNLEGQPFYSKKDRPLCKK 720



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 23/56 (41%), Positives = 28/56 (50%), Gaps = 5/56 (8%)

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDC 292
           C  C N I    +G  +VA  G+SWH   F C  C  +LA+  FV  Q  VYC  C
Sbjct: 551 CGHCNNVI----RGPFLVAM-GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERC 601


>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
          Length = 423

 Score =  109 bits (272), Expect = 3e-24
 Identities = 56/176 (31%), Positives = 78/176 (44%), Gaps = 5/176 (2%)

Query: 114 SPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETK 173
           +P C  C K ++ G   V   G  +H + F CS C +V+  G FF +    +C  C++ +
Sbjct: 245 TPVCHQCHK-VIRGRYLVAL-GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVR 302

Query: 174 FAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFV 233
           +A  C KC K IT   +      WH  CF C  C   +  + F   E   YC   Y+   
Sbjct: 303 YAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362

Query: 234 AKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
             KC GC   I     G   +   G SWHD CF C  C +NL  K F   +++  C
Sbjct: 363 GTKCHGCDFKIDA---GDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 415



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 45/148 (30%), Positives = 69/148 (46%), Gaps = 2/148 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E+F C  C   L+   + ++ G   C  C+D   A +C +C+K I  +   +H     WH
Sbjct: 270 EEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEI--MHALKMTWH 327

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
             CF CA C  P+ N  F  ++    C +   +    KC GC   I AGD+ +E  G  W
Sbjct: 328 VHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSW 387

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 166
           H  CF C+ C+  +   +F+ K +   C
Sbjct: 388 HDTCFVCAICQINLEGKTFYSKKDRPLC 415



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 51/172 (29%), Positives = 72/172 (41%), Gaps = 6/172 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C +C K I    + +      +H   F C++C   L    F  +   I C  C     +P
Sbjct: 248 CHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
            C  C K I  G+     K T WH  CFTC+ CK  I   +F+ +    YC   +E  F 
Sbjct: 306 SCAKCKKKI-TGEIMHALKMT-WHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 363

Query: 176 KHCVKCNKAITSGG--ITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 225
             C  C+  I +G   +      WH  CFVC  C   L G+ F + +D+  C
Sbjct: 364 TKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 415


>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
          Length = 457

 Score =  109 bits (272), Expect = 3e-24
 Identities = 56/176 (31%), Positives = 78/176 (44%), Gaps = 5/176 (2%)

Query: 114 SPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETK 173
           +P C  C K ++ G   V   G  +H + F CS C +V+  G FF +    +C  C++ +
Sbjct: 279 TPVCHQCHK-VIRGRYLVAL-GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVR 336

Query: 174 FAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFV 233
           +A  C KC K IT   +      WH  CF C  C   +  + F   E   YC   Y+   
Sbjct: 337 YAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 396

Query: 234 AKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
             KC GC   I     G   +   G SWHD CF C  C +NL  K F   +++  C
Sbjct: 397 GTKCHGCDFKIDA---GDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 449



 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 45/148 (30%), Positives = 69/148 (46%), Gaps = 2/148 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E+F C  C   L+   + ++ G   C  C+D   A +C +C+K I  +   +H     WH
Sbjct: 304 EEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEI--MHALKMTWH 361

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
             CF CA C  P+ N  F  ++    C +   +    KC GC   I AGD+ +E  G  W
Sbjct: 362 VHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSW 421

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 166
           H  CF C+ C+  +   +F+ K +   C
Sbjct: 422 HDTCFVCAICQINLEGKTFYSKKDRPLC 449



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 51/172 (29%), Positives = 72/172 (41%), Gaps = 6/172 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C +C K I    + +      +H   F C++C   L    F  +   I C  C     +P
Sbjct: 282 CHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 339

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
            C  C K I  G+     K T WH  CFTC+ CK  I   +F+ +    YC   +E  F 
Sbjct: 340 SCAKCKKKI-TGEIMHALKMT-WHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 397

Query: 176 KHCVKCNKAITSGG--ITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 225
             C  C+  I +G   +      WH  CFVC  C   L G+ F + +D+  C
Sbjct: 398 TKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 449


>gi|109638745 transforming growth factor beta 1 induced transcript 1
           isoform 1 [Homo sapiens]
          Length = 461

 Score =  105 bits (262), Expect = 5e-23
 Identities = 72/241 (29%), Positives = 92/241 (38%), Gaps = 9/241 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C  C KPI    + V    R WH   F C  C   L   +F  KD    C +C     SP
Sbjct: 228 CGSCNKPIAG--QVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSP 285

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
           +C  C + I    + V   GT WH + F C +C +  G   F  +    YC       FA
Sbjct: 286 RCGFCNQPI--RHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343

Query: 176 KHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAK 235
             C  C   I    I+     WH DCFVC  C    +G  F   E +  C + +      
Sbjct: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403

Query: 236 KCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
            CA C  P+TG       V+  G+ +H   F C  C   L    F     + YC  C  K
Sbjct: 404 LCATCGLPVTG-----RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLK 458

Query: 296 L 296
           L
Sbjct: 459 L 459



 Score =  101 bits (252), Expect = 7e-22
 Identities = 57/211 (27%), Positives = 85/211 (40%), Gaps = 4/211 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C  C   L G  + +KDG   C +C+ +  +  C  C +PI    K V      WH
Sbjct: 250 EHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPI--RHKMVTALGTHWH 307

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
              F C  C  P  +E F  ++ +  C +   +  +P+C+GC   I+  D  +     +W
Sbjct: 308 PEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALW 365

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWH 198
           H DCF C  C      GSFF       C      +    C  C   +T   ++   + +H
Sbjct: 366 HPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFH 425

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
            D F C  C + L    F     + YC  C+
Sbjct: 426 PDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 25/113 (22%), Positives = 40/113 (35%), Gaps = 31/113 (27%)

Query: 203 VCVTCSKKLAGQRFTAV--------------------------EDQYYCVDCYKNFVAKK 236
           +C +C+K +AGQ  TA+                          +   +C +CY    + +
Sbjct: 227 LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR 286

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           C  C  PI        +V   G  WH   F C  C     ++ F   + + YC
Sbjct: 287 CGFCNQPIR-----HKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC 334


>gi|21361591 transforming growth factor beta 1 induced transcript 1
           isoform 2 [Homo sapiens]
          Length = 444

 Score =  105 bits (262), Expect = 5e-23
 Identities = 72/241 (29%), Positives = 92/241 (38%), Gaps = 9/241 (3%)

Query: 56  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 115
           C  C KPI    + V    R WH   F C  C   L   +F  KD    C +C     SP
Sbjct: 211 CGSCNKPIAG--QVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSP 268

Query: 116 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 175
           +C  C + I    + V   GT WH + F C +C +  G   F  +    YC       FA
Sbjct: 269 RCGFCNQPI--RHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 326

Query: 176 KHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAK 235
             C  C   I    I+     WH DCFVC  C    +G  F   E +  C + +      
Sbjct: 327 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 386

Query: 236 KCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
            CA C  P+TG       V+  G+ +H   F C  C   L    F     + YC  C  K
Sbjct: 387 LCATCGLPVTG-----RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLK 441

Query: 296 L 296
           L
Sbjct: 442 L 442



 Score =  101 bits (252), Expect = 7e-22
 Identities = 57/211 (27%), Positives = 85/211 (40%), Gaps = 4/211 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E F C  C   L G  + +KDG   C +C+ +  +  C  C +PI    K V      WH
Sbjct: 233 EHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPI--RHKMVTALGTHWH 290

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
              F C  C  P  +E F  ++ +  C +   +  +P+C+GC   I+  D  +     +W
Sbjct: 291 PEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPIL--DNYISALSALW 348

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWH 198
           H DCF C  C      GSFF       C      +    C  C   +T   ++   + +H
Sbjct: 349 HPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFH 408

Query: 199 ADCFVCVTCSKKLAGQRFTAVEDQYYCVDCY 229
            D F C  C + L    F     + YC  C+
Sbjct: 409 PDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 439



 Score = 36.6 bits (83), Expect = 0.027
 Identities = 25/113 (22%), Positives = 40/113 (35%), Gaps = 31/113 (27%)

Query: 203 VCVTCSKKLAGQRFTAV--------------------------EDQYYCVDCYKNFVAKK 236
           +C +C+K +AGQ  TA+                          +   +C +CY    + +
Sbjct: 210 LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR 269

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 289
           C  C  PI        +V   G  WH   F C  C     ++ F   + + YC
Sbjct: 270 CGFCNQPIR-----HKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC 317


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score =  104 bits (260), Expect = 8e-23
 Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 10/200 (5%)

Query: 90  PLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCK 149
           P   +T V +   I   K T     P C  C   ++ G   V   G  WH + F C++CK
Sbjct: 289 PSDQDTLVQRAEHIPAGKRT-----PMCAHC-NQVIRGPFLVAL-GKSWHPEEFNCAHCK 341

Query: 150 QVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSK 209
             +    F  +    YC  C+E  FA  C +C + I    I+   Q WH  CFVCV C K
Sbjct: 342 NTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGK 401

Query: 210 KLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCK 269
            +    F   + + YC   Y       C GC+ PI     G   +   G +WHD CF C 
Sbjct: 402 PIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEA---GDMFLEALGYTWHDTCFVCS 458

Query: 270 KCSVNLANKRFVFHQEQVYC 289
            C  +L  + F   +++  C
Sbjct: 459 VCCESLEGQTFFSKKDKPLC 478



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 45/148 (30%), Positives = 70/148 (47%), Gaps = 2/148 (1%)

Query: 19  EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 78
           E+F+C +C++ +    +V++ G   C  C++KF A  C  C++ I  +   +    + WH
Sbjct: 333 EEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGE--VISALKQTWH 390

Query: 79  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 138
            +CF C  C  P+ N  F  +D +  C           C GC   I AGD  +E  G  W
Sbjct: 391 VSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTW 450

Query: 139 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 166
           H  CF CS C + +   +FF K +   C
Sbjct: 451 HDTCFVCSVCCESLEGQTFFSKKDKPLC 478



 Score = 82.8 bits (203), Expect = 3e-16
 Identities = 47/151 (31%), Positives = 68/151 (45%), Gaps = 4/151 (2%)

Query: 77  WHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGT 136
           WH   F CA C + +A   FV +   + C  C  +  +P+C  C + I+ G+     K T
Sbjct: 330 WHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKIL-GEVISALKQT 388

Query: 137 VWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQ--D 194
            WH  CF C  C + I    F  +  + YC T +   F   C  C   I +G +  +   
Sbjct: 389 -WHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALG 447

Query: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 225
             WH  CFVC  C + L GQ F + +D+  C
Sbjct: 448 YTWHDTCFVCSVCCESLEGQTFFSKKDKPLC 478



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 28/87 (32%), Positives = 38/87 (43%)

Query: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80
           F C  C  P++   +  +DG   C   +       C  C  PI A    +      WHDT
Sbjct: 394 FVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDT 453

Query: 81  CFRCAKCLHPLANETFVAKDNKILCNK 107
           CF C+ C   L  +TF +K +K LC K
Sbjct: 454 CFVCSVCCESLEGQTFFSKKDKPLCKK 480



 Score = 35.4 bits (80), Expect = 0.061
 Identities = 21/59 (35%), Positives = 29/59 (49%), Gaps = 5/59 (8%)

Query: 237 CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPDCAKK 295
           CA C   I    +G  +VA  G+SWH   F+C  C   +A   FV  +  +YC  C +K
Sbjct: 311 CAHCNQVI----RGPFLVAL-GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEK 364


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.137    0.488 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,314,678
Number of Sequences: 37866
Number of extensions: 677741
Number of successful extensions: 7136
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 612
Number of HSP's that attempted gapping in prelim test: 2515
Number of HSP's gapped (non-prelim): 2367
length of query: 296
length of database: 18,247,518
effective HSP length: 102
effective length of query: 194
effective length of database: 14,385,186
effective search space: 2790726084
effective search space used: 2790726084
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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