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Search of human proteins with 227496440
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|227496440 multiple C2 domains, transmembrane 2 isoform 1
[Homo sapiens]
(878 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Hom... 1744 0.0
gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Hom... 1602 0.0
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 737 0.0
gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo... 735 0.0
gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Hom... 573 e-163
gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens] 102 2e-21
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 81 5e-15
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 81 5e-15
gi|45387945 family with sequence similarity 62 (C2 domain contai... 80 1e-14
gi|103472031 family with sequence similarity 62 (C2 domain conta... 74 6e-13
gi|6005997 double C2-like domains, beta [Homo sapiens] 70 1e-11
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 67 6e-11
gi|67763814 death-inducing-protein [Homo sapiens] 67 6e-11
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 67 9e-11
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 67 9e-11
gi|122937514 unc-13 homolog C [Homo sapiens] 66 2e-10
gi|38570146 synaptotagmin VII [Homo sapiens] 66 2e-10
gi|21361472 neural precursor cell expressed, developmentally dow... 65 3e-10
gi|222352086 neural precursor cell expressed, developmentally do... 65 3e-10
gi|222352090 neural precursor cell expressed, developmentally do... 65 4e-10
gi|222352088 neural precursor cell expressed, developmentally do... 65 4e-10
gi|122937247 unc-13 homolog A [Homo sapiens] 64 5e-10
gi|47078261 double C2-like domains, alpha [Homo sapiens] 62 2e-09
gi|110611226 UNC13 (C. elegans)-like [Homo sapiens] 62 2e-09
gi|45504376 synaptotagmin VI [Homo sapiens] 62 3e-09
gi|114520609 neural precursor cell expressed, developmentally do... 60 7e-09
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens] 59 2e-08
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens] 59 2e-08
gi|13384594 protein kinase C, gamma [Homo sapiens] 59 2e-08
gi|4506067 protein kinase C, alpha [Homo sapiens] 58 3e-08
>gi|227496440 multiple C2 domains, transmembrane 2 isoform 1 [Homo
sapiens]
Length = 878
Score = 1744 bits (4518), Expect = 0.0
Identities = 878/878 (100%), Positives = 878/878 (100%)
Query: 1 MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60
MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA
Sbjct: 1 MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60
Query: 61 LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120
LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS
Sbjct: 61 LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120
Query: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180
EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE
Sbjct: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180
Query: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240
ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP
Sbjct: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240
Query: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300
VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL
Sbjct: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300
Query: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360
EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI
Sbjct: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360
Query: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420
TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV
Sbjct: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420
Query: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480
WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV
Sbjct: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480
Query: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540
CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN
Sbjct: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540
Query: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600
DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG
Sbjct: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600
Query: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660
QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD
Sbjct: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660
Query: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN 720
VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN
Sbjct: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN 720
Query: 721 FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS 780
FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS
Sbjct: 721 FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS 780
Query: 781 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 840
FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN
Sbjct: 781 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 840
Query: 841 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL
Sbjct: 841 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
>gi|227496489 multiple C2 domains, transmembrane 2 isoform 2 [Homo
sapiens]
Length = 823
Score = 1602 bits (4149), Expect = 0.0
Identities = 820/878 (93%), Positives = 822/878 (93%), Gaps = 55/878 (6%)
Query: 1 MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60
MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA
Sbjct: 1 MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHLDRRLSLSVPDLLEAEA 60
Query: 61 LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120
LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS
Sbjct: 61 LAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDS 120
Query: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180
EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE
Sbjct: 121 EEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGE 180
Query: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240
ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP
Sbjct: 181 ASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNP 240
Query: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300
VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL
Sbjct: 241 VWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSL 300
Query: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360
EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI
Sbjct: 301 EDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISI 360
Query: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420
TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV
Sbjct: 361 TLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEV 420
Query: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480
WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV
Sbjct: 421 WGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCV 480
Query: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540
CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN
Sbjct: 481 CPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGN 540
Query: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600
DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG
Sbjct: 541 DRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDG 600
Query: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660
QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD
Sbjct: 601 QPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRD 660
Query: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYN 720
VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA
Sbjct: 661 VDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA------------------------- 695
Query: 721 FIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIAS 780
E +K+ GLIERIYMVQDIVSTVQNVLEEIAS
Sbjct: 696 --------------------------ESEKK----GLIERIYMVQDIVSTVQNVLEEIAS 725
Query: 781 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 840
FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN
Sbjct: 726 FGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDN 785
Query: 841 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL
Sbjct: 786 NELLDFLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 823
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 737 bits (1903), Expect = 0.0
Identities = 410/873 (46%), Positives = 553/873 (63%), Gaps = 72/873 (8%)
Query: 62 APEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEELDWSQEEASHLHVVETDSE 121
A G P G S S PSS S + SS SS Q D +++E + +
Sbjct: 142 AAGGTPPGG--RSPDSAPSSSSAS-----SSLSSSPQPPPRGDRARDEGAR-------RQ 187
Query: 122 EAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGSSDLNASMTSQ-HFEEQSVPGE 180
A ++ S G L++ P EP + ++ A T + H Q +
Sbjct: 188 GPGAHLCHQKSSSLPGTACLEQLLEPPPPPAEPAR--SPAESRAPETGEEHGSSQKIINT 245
Query: 181 ASDGLSNLP--SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNL 238
A + +P P Y L I L+ G++L RDR GTSDPYVKFK+ GK +++SK+I+KNL
Sbjct: 246 AGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNL 305
Query: 239 NPVWDEIVVLPIQSLDQKLRVKVYDRDL-TTSDFMGSAFVILSDLELNRTTEHILKLEDP 297
NPVW+E + + L + L +KV+D D DFMGSAF+ L+ LELNR T+ L L+DP
Sbjct: 306 NPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDP 365
Query: 298 NSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN---------------- 341
+ + D+G+I+L++ L K+G+ + RK S L N
Sbjct: 366 HYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRT 425
Query: 342 ------------------------------LRLSESLKKNQLWNGIISITLLEGKNVSG- 370
LRLS+ +K+ LW GI+SITL+EG+++
Sbjct: 426 CGRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAM 485
Query: 371 --GSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKH 428
+++ +V+ +LG Q+YKSK + K+ NPQW+EQFDFH + +R G++DI W KD K
Sbjct: 486 DSNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKR 545
Query: 429 EERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSE 488
++ +G C+VD+SAL +Q + LEL L+ G L++LVTLT A VS+SDL V L D E
Sbjct: 546 DDFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKE 605
Query: 489 RKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTV 548
R++I +RY ++KDVG LQVKV++A L+AAD +GKSDPFC++EL NDRL THTV
Sbjct: 606 REEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTV 665
Query: 549 YKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLK 608
YKNLNPEWNKVFTF IKDIH VLEVTV+DED D+ DFLGKVAIPLLSI++G+ YVLK
Sbjct: 666 YKNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLK 725
Query: 609 NKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRIT 668
NK L KGVIYLE+D+I+N VKAS+RT P+E++++E+ +LSK++L R+ R+KR
Sbjct: 726 NKQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCV 785
Query: 669 MAIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGK 728
M + N ++ SCF W+S RS AF +FL VWNFELYMIPL LLL+ +N+ + GK
Sbjct: 786 MVLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGK 845
Query: 729 VSSIQDSQESTDIDDEE---DEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERI 785
+ +D+ ++DEE D+DDK+SEKKG I +IY +Q++ +VQN+L+E+ASFGERI
Sbjct: 846 DNRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERI 905
Query: 786 KNTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLD 845
KNTFNWTVPFLS LA + L T ILY IPLRYI+L+WGINKFTKKLR+PY+IDNNELLD
Sbjct: 906 KNTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLD 965
Query: 846 FLSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
FLSRVPSDVQ VQY ELK SHSP ++K++ L
Sbjct: 966 FLSRVPSDVQVVQYQELKPDPSHSPYKRKKNNL 998
>gi|50582996 multiple C2 domains, transmembrane 1 isoform S [Homo
sapiens]
Length = 778
Score = 735 bits (1898), Expect = 0.0
Identities = 384/752 (51%), Positives = 510/752 (67%), Gaps = 57/752 (7%)
Query: 184 GLSNLPSPFA----YLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLN 239
G SN P A Y L I L+ G++L RDR GTSDPYVKFK+ GK +++SK+I+KNLN
Sbjct: 26 GTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSKIIHKNLN 85
Query: 240 PVWDEIVVLPIQSLDQKLRVKVYDRDL-TTSDFMGSAFVILSDLELNRTTEHILKLEDPN 298
PVW+E + + L + L +KV+D D DFMGSAF+ L+ LELNR T+ L L+DP+
Sbjct: 86 PVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVTLTLKDPH 145
Query: 299 SLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN----------------- 341
+ D+G+I+L++ L K+G+ + RK S L N
Sbjct: 146 YPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVKSLFWRTC 205
Query: 342 -----------------------------LRLSESLKKNQLWNGIISITLLEGKNVSG-- 370
LRLS+ +K+ LW GI+SITL+EG+++
Sbjct: 206 GRPALPVLGFCRAELQNPYCKNVQFQTQSLRLSDLHRKSHLWRGIVSITLIEGRDLKAMD 265
Query: 371 -GSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHE 429
+++ +V+ +LG Q+YKSK + K+ NPQW+EQFDFH + +R G++DI W KD K +
Sbjct: 266 SNGLSDPYVKFRLGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGVIDITAWDKDAGKRD 325
Query: 430 ERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSER 489
+ +G C+VD+SAL +Q + LEL L+ G L++LVTLT A VS+SDL V L D ER
Sbjct: 326 DFIGRCQVDLSALSREQTHKLELQLEEGEGHLVLLVTLTASATVSISDLSVNSLEDQKER 385
Query: 490 KQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVY 549
++I +RY ++KDVG LQVKV++A L+AAD +GKSDPFC++EL NDRL THTVY
Sbjct: 386 EEILKRYSPLRIFHNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVY 445
Query: 550 KNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKN 609
KNLNPEWNKVFTF IKDIH VLEVTV+DED D+ DFLGKVAIPLLSI++G+ YVLKN
Sbjct: 446 KNLNPEWNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGKVAIPLLSIQNGEQKAYVLKN 505
Query: 610 KDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITM 669
K L KGVIYLE+D+I+N VKAS+RT P+E++++E+ +LSK++L R+ R+KR M
Sbjct: 506 KQLTGPTKGVIYLEIDVIFNAVKASLRTLIPKEQKYIEEENRLSKQLLLRNFIRMKRCVM 565
Query: 670 AIWNTMQFLKSCFQWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGKV 729
+ N ++ SCF W+S RS AF +FL VWNFELYMIPL LLL+ +N+ + GK
Sbjct: 566 VLVNAAYYVNSCFDWDSPPRSLAAFVLFLFVVWNFELYMIPLVLLLLLTWNYFLIISGKD 625
Query: 730 SSIQDSQESTDIDDEE---DEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERIK 786
+ +D+ ++DEE D+DDK+SEKKG I +IY +Q++ +VQN+L+E+ASFGERIK
Sbjct: 626 NRQRDTVVEDMLEDEEEEDDKDDKDSEKKGFINKIYAIQEVCVSVQNILDEVASFGERIK 685
Query: 787 NTFNWTVPFLSSLACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDF 846
NTFNWTVPFLS LA + L T ILY IPLRYI+L+WGINKFTKKLR+PY+IDNNELLDF
Sbjct: 686 NTFNWTVPFLSWLAIVALCVFTAILYCIPLRYIVLVWGINKFTKKLRSPYAIDNNELLDF 745
Query: 847 LSRVPSDVQKVQYAELKLCSSHSPLRKKRSAL 878
LSRVPSDVQ VQY ELK SHSP ++K++ L
Sbjct: 746 LSRVPSDVQVVQYQELKPDPSHSPYKRKKNNL 777
Score = 55.8 bits (133), Expect = 2e-07
Identities = 45/189 (23%), Positives = 80/189 (42%), Gaps = 7/189 (3%)
Query: 490 KQITQRYCLQNSLKDVKDVGILQVKVL--KAADLLAADFSGKSDPFCLLELGNDRL-QTH 546
K+I N+ + D G+ Q+ + + L A D G SDP+ ++G + ++
Sbjct: 19 KKIINTAGTSNAEVPLADPGMYQLDITLRRGQSLAARDRGGTSDPYVKFKIGGKEVFRSK 78
Query: 547 TVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYV 606
++KNLNP W + + + + L + VFD D DF+G + L + +P
Sbjct: 79 IIHKNLNPVWEEKACILVDHLREPLYIKVFDYDFGLQDDFMGSAFLDLTQLELNRPTDVT 138
Query: 607 LKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTP-REKRFVEDSRKLSKKILSRDVDRVK 665
L KD + + + +I P + R T K + S++LS+ + VK
Sbjct: 139 LTLKDPHYPDHDLGIILLSVILTPKEGESRDVTMLMRKSWKRSSKELSENEVVGSYFSVK 198
Query: 666 RITMAIWNT 674
+ W T
Sbjct: 199 SL---FWRT 204
>gi|227496504 multiple C2 domains, transmembrane 2 isoform 3 [Homo
sapiens]
Length = 306
Score = 573 bits (1476), Expect = e-163
Identities = 283/283 (100%), Positives = 283/283 (100%)
Query: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 472
MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG
Sbjct: 1 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTPCAG 60
Query: 473 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 532
VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP
Sbjct: 61 VSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDP 120
Query: 533 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 592
FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI
Sbjct: 121 FCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAI 180
Query: 593 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 652
PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL
Sbjct: 181 PLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEMDLIYNPVKASIRTFTPREKRFVEDSRKL 240
Query: 653 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA 695
SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA
Sbjct: 241 SKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFA 283
Score = 58.5 bits (140), Expect = 3e-08
Identities = 37/122 (30%), Positives = 64/122 (52%), Gaps = 6/122 (4%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLD 254
+L + + + +L+ D G SDP+ +L L ++ +YKNLNP W+++ PI+ +
Sbjct: 98 ILQVKVLKAADLLAADFSGKSDPFCLLELGNDRL-QTHTVYKNLNPEWNKVFTFPIKDIH 156
Query: 255 QKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDM-GVIVLNLN 312
L V V+D D DF+G + L + + ++LK +D LE GVI L ++
Sbjct: 157 DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD---LEQAFKGVIYLEMD 213
Query: 313 LV 314
L+
Sbjct: 214 LI 215
Score = 45.8 bits (107), Expect = 2e-04
Identities = 26/100 (26%), Positives = 52/100 (52%), Gaps = 4/100 (4%)
Query: 356 GIISITLLEGKNVSGGSMT---EMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
GI+ + +L+ ++ + + F L+LG+ R ++ T+ K+ NP+W + F F D
Sbjct: 97 GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFP-IKDI 155
Query: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLEL 452
+L++ V+ +D K + LG + + ++ Q NC L
Sbjct: 156 HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVL 195
>gi|14149680 extended synaptotagmin-like protein 1 [Homo sapiens]
Length = 1104
Score = 102 bits (254), Expect = 2e-21
Identities = 118/443 (26%), Positives = 191/443 (43%), Gaps = 71/443 (16%)
Query: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVL 248
++ IHL R L +D+ G SDPY +L +T + S+VI + LNP W E +
Sbjct: 330 IIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQT-FCSRVIDEELNPQWGETYEV 388
Query: 249 PIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
+ + Q++ V+V+D+D DF+G L++ + + + L+D L+ G +
Sbjct: 389 MVHEVPGQEIEVEVFDKDPDKDDFLGRM-----KLDVGKVLQASV-LDDWFPLQGGQGQV 442
Query: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
L L + D A K + S + + I+ + L ++
Sbjct: 443 HLRLEWLSLLSD-------------AEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRAQD 489
Query: 368 V---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKD 424
+ G VQL + D +SK + + P W+E F F + LD++V KD
Sbjct: 490 LPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQV--KD 547
Query: 425 NKKHEERLGTCKVDISALPLKQANCL---ELPLDSCL-------GALLMLVTLTPCAGVS 474
+ + + + AL L A L EL LD + L + + +
Sbjct: 548 DSR--------ALTLGALTLPLARLLTAPELILDQWFQLSSSGPNSRLYMKLVMRILYLD 599
Query: 475 VSDLCV-----CPLA-DL-SERKQ------ITQRYCLQNSLKDVKDVGILQVKVLKAADL 521
S++C CP A D+ SE Q R C +L++ VL+A DL
Sbjct: 600 SSEICFPTVPGCPGAWDVDSENPQRGSSVDAPPRPCHTTPDSQFGTEHVLRIHVLEAQDL 659
Query: 522 LAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDI-HDVLEVT 574
+A D GKSDP+ L+L ++H V ++LNP WN+VF + + LEV
Sbjct: 660 IAKDRFLGGLVKGKSDPYVKLKLAGRSFRSHVVREDLNPRWNEVFEVIVTSVPGQELEVE 719
Query: 575 VFDEDGDKPPDFLGKVAIPLLSI 597
VFD+D DK DFLG+ + L ++
Sbjct: 720 VFDKDLDK-DDFLGRCKVRLTTV 741
Score = 89.4 bits (220), Expect = 1e-17
Identities = 76/286 (26%), Positives = 139/286 (48%), Gaps = 34/286 (11%)
Query: 194 YLLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVV 247
++L IH+ E ++L+ +DR G SDPYVK KL G++ ++S V+ ++LNP W+E+
Sbjct: 647 HVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKLAGRS-FRSHVVREDLNPRWNEVFE 705
Query: 248 LPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGV 306
+ + S+ Q+L V+V+D+DL DF+G V L+ + + + L LED S G
Sbjct: 706 VIVTSVPGQELEVEVFDKDLDKDDFLGRCKVRLTTVLNSGFLDEWLTLEDVPS-----GR 760
Query: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
+ L L + + +A +++ L ++ K +L ++SI + +
Sbjct: 761 LHLRLERLTP------------RPTAAELEEVLQVNSLIQTQKSAELAAALLSIYMERAE 808
Query: 367 NV---SGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
++ G + L +GD +K+KT+ +++ P W E F L+++V G+
Sbjct: 809 DLPLRKGTKHLSPYATLTVGDSSHKTKTISQTSAPVWDESASFLIRKPHTESLELQVRGE 868
Query: 424 DNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCLGALLMLVTL 467
LG+ + +S L + CL+ L S G +L+ L
Sbjct: 869 GTGV----LGSLSLPLSELLVADQLCLDRWFTLSSGQGQVLLRAQL 910
Score = 55.5 bits (132), Expect = 2e-07
Identities = 30/91 (32%), Positives = 51/91 (56%), Gaps = 8/91 (8%)
Query: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTF 562
GI+++ +L A L + D GKSDP+ L+ LG + + + LNP+W + +
Sbjct: 329 GIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQWGETYEV 388
Query: 563 PIKDI-HDVLEVTVFDEDGDKPPDFLGKVAI 592
+ ++ +EV VFD+D DK DFLG++ +
Sbjct: 389 MVHEVPGQEIEVEVFDKDPDK-DDFLGRMKL 418
Score = 55.1 bits (131), Expect = 3e-07
Identities = 62/257 (24%), Positives = 111/257 (43%), Gaps = 30/257 (11%)
Query: 350 KNQLWNGIISITLLEGKNVSGGSM---------TEMFVQLKLGDQRYKSKTLCKSANPQW 400
++ L GII I LL + +S ++ + ++LG Q + S+ + + NPQW
Sbjct: 323 RSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRLGTQTFCSRVIDEELNPQW 382
Query: 401 QEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLE--LPLDSCL 458
E ++ +++EV+ KD K ++ LG K+D+ + QA+ L+ PL
Sbjct: 383 GETYEVMVHEVPGQEIEVEVFDKDPDK-DDFLGRMKLDVGKV--LQASVLDDWFPLQGGQ 439
Query: 459 GALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKA 518
G + + + L+D + +Q+ Q +S D IL V + +A
Sbjct: 440 GQVHLRLEWLSL------------LSDAEKLEQVLQWNWGVSSRPDPPSAAILVVYLDRA 487
Query: 519 ADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFD 577
DL + + +P L + + ++ VY P W + F F ++D L+V V D
Sbjct: 488 QDLPLKKGNKEPNPMVQLSIQDVTQESKAVYSTNCPVWEEAFRFFLQDPQSQELDVQVKD 547
Query: 578 EDGDKPPDFLGKVAIPL 594
D LG + +PL
Sbjct: 548 ---DSRALTLGALTLPL 561
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 80.9 bits (198), Expect = 5e-15
Identities = 45/116 (38%), Positives = 68/116 (58%), Gaps = 3/116 (2%)
Query: 487 SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 546
+E+K+ + Y Q + +G L V V++A +L A +GKS+P+C + +G+ T
Sbjct: 1522 TEKKKREKAY--QARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTR 1579
Query: 547 TVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 601
T+ LNP+WN F IKD++ DVL +T+FD D P DFLG+ IP+ IR Q
Sbjct: 1580 TIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1635
Score = 33.5 bits (75), Expect = 0.89
Identities = 18/90 (20%), Positives = 43/90 (47%), Gaps = 2/90 (2%)
Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGIL 416
+I T L+ +G S + ++ +G Q Y ++T+ + NP+W F +L
Sbjct: 1548 VIEATELKACKPNGKS--NPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVL 1605
Query: 417 DIEVWGKDNKKHEERLGTCKVDISALPLKQ 446
+ ++ +D ++ LG ++ ++ + +Q
Sbjct: 1606 CLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1635
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 80.9 bits (198), Expect = 5e-15
Identities = 45/116 (38%), Positives = 68/116 (58%), Gaps = 3/116 (2%)
Query: 487 SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 546
+E+K+ + Y Q + +G L V V++A +L A +GKS+P+C + +G+ T
Sbjct: 1549 TEKKKREKAY--QARSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTR 1606
Query: 547 TVYKNLNPEWNKVFTFPIKDIH-DVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 601
T+ LNP+WN F IKD++ DVL +T+FD D P DFLG+ IP+ IR Q
Sbjct: 1607 TIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1662
Score = 33.5 bits (75), Expect = 0.89
Identities = 18/90 (20%), Positives = 43/90 (47%), Gaps = 2/90 (2%)
Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGIL 416
+I T L+ +G S + ++ +G Q Y ++T+ + NP+W F +L
Sbjct: 1575 VIEATELKACKPNGKS--NPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVL 1632
Query: 417 DIEVWGKDNKKHEERLGTCKVDISALPLKQ 446
+ ++ +D ++ LG ++ ++ + +Q
Sbjct: 1633 CLTLFDRDQFSPDDFLGRTEIPVAKIRTEQ 1662
>gi|45387945 family with sequence similarity 62 (C2 domain
containing) member B [Homo sapiens]
Length = 893
Score = 79.7 bits (195), Expect = 1e-14
Identities = 63/259 (24%), Positives = 121/259 (46%), Gaps = 32/259 (12%)
Query: 195 LLTIHLKEGRNLVVRDRC------GTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIV-V 247
+L IH E ++L +D G SDPY ++ G +++S+VI +NL+P W+E+
Sbjct: 358 VLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRV-GNQIFQSRVIKENLSPKWNEVYEA 416
Query: 248 LPIQSLDQKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVI 307
L + Q+L ++++D D DF+GS + L ++E R + L++
Sbjct: 417 LVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDE----------- 465
Query: 308 VLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKN 367
V K R W +++ ++ +++ + + L + ++ + L +N
Sbjct: 466 ------VPKGKLHLRLEWLTLMPNASNLDKVLTDIKADKDQANDGLSSALLILYLDSARN 519
Query: 368 VSGG----SMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGK 423
+ G S VQ+ +G + +SK K+ P W+E F F + + L++EV
Sbjct: 520 LPSGKKISSNPNPVVQMSVGHKAQESKIRYKTNEPVWEENFTFFIHNPKRQDLEVEV--- 576
Query: 424 DNKKHEERLGTCKVDISAL 442
+++H+ LG KV +S L
Sbjct: 577 RDEQHQCSLGNLKVPLSQL 595
Score = 63.5 bits (153), Expect = 8e-10
Identities = 34/96 (35%), Positives = 56/96 (58%), Gaps = 8/96 (8%)
Query: 509 GILQVKVLKAADLLAAD------FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVF-T 561
G+L++ ++A DL D GKSDP+ ++ +GN Q+ + +NL+P+WN+V+
Sbjct: 357 GVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSRVIKENLSPKWNEVYEA 416
Query: 562 FPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSI 597
+ LE+ +FDED DK DFLG + I L+ +
Sbjct: 417 LVYEHPGQELEIELFDEDPDK-DDFLGSLMIDLIEV 451
Score = 30.4 bits (67), Expect = 7.5
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 10/94 (10%)
Query: 513 VKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPI--- 564
+ V+ A L A SDP+ + L D R +TH K LNP +++ F F +
Sbjct: 776 IVVVHACRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLP 835
Query: 565 KDIHDVLEVTVFDEDG--DKPPDFLGKVAIPLLS 596
+ L+V V + G K LGKV + L S
Sbjct: 836 EVQRRTLDVAVKNSGGFLSKDKGLLGKVLVALAS 869
>gi|103472031 family with sequence similarity 62 (C2 domain
containing), member C [Homo sapiens]
Length = 886
Score = 73.9 bits (180), Expect = 6e-13
Identities = 74/282 (26%), Positives = 120/282 (42%), Gaps = 30/282 (10%)
Query: 176 SVPGEASDGLSNLPSPFAY-LLTIHLKEGRNLVVRDRC----GTSDPYVKFKLNGKTLYK 230
+VP + L+NL P ++ +HL E L +D G SDPY K + G ++
Sbjct: 287 TVPVKKGLDLTNLRFPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSI-GLQHFR 345
Query: 231 SKVIYKNLNPVWDEIVVLPIQSLD-QKLRVKVYDRDLTTSDFMGSAFVILSDLELNRTTE 289
S+ IY+NLNP W+E+ + + Q L V +YD D DF+GS + L D+ NR +
Sbjct: 346 SRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVD 405
Query: 290 HILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLK 349
L D S G + L L + D S + L+ L + +L
Sbjct: 406 EWFVLNDTTS-----GRLHLRLEWLSLLTD---QEVLTEDHGGLSTAILVVFLESACNLP 457
Query: 350 KN--QLWNG---IISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQF 404
+N NG ++ VS + +V+L +G + + SKT + +P W + F
Sbjct: 458 RNPFDYLNGEYRAKKLSRFARNKVSKDPSS--YVKLSVGKKTHTSKTCPHNKDPVWSQVF 515
Query: 405 DFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQ 446
F + L ++V D + C + + +PL Q
Sbjct: 516 SFFVHNVATERLHLKVLDDDQE--------CALGMLEVPLCQ 549
Score = 67.8 bits (164), Expect = 4e-11
Identities = 36/91 (39%), Positives = 56/91 (61%), Gaps = 6/91 (6%)
Query: 509 GILQVKVLKAADLLAAD----FSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPI 564
G+++V +L+A L D GKSDP+ + +G ++ T+Y+NLNP WN+VF F +
Sbjct: 306 GVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEVFEFMV 365
Query: 565 KDI-HDVLEVTVFDEDGDKPPDFLGKVAIPL 594
++ LEV ++DED D+ DFLG + I L
Sbjct: 366 YEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
Score = 42.7 bits (99), Expect = 0.001
Identities = 60/301 (19%), Positives = 126/301 (41%), Gaps = 31/301 (10%)
Query: 327 NRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGS-------MTEMFVQ 379
NR + K + NLR L G+I + LLE + ++ ++ + +
Sbjct: 284 NRVTVPVKKGLDLTNLRFP-------LPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAK 336
Query: 380 LKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDI 439
+ +G Q ++S+T+ ++ NP W E F+F + L+++++ +D + ++ LG+ ++ +
Sbjct: 337 VSIGLQHFRSRTIYRNLNPTWNEVFEFMVYEVPGQDLEVDLYDEDTDR-DDFLGSLQICL 395
Query: 440 SALPLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQ 499
+ + L+ L L L + ++ ++ LS +
Sbjct: 396 GDVMTNRVVDEWFVLNDTTSGRLHL-RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESAC 454
Query: 500 NSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKV 559
N ++ D + + K + S + L +G + T N +P W++V
Sbjct: 455 NLPRNPFDYLNGEYRAKKLSRFARNKVSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQV 514
Query: 560 FTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKD--LEQAF 616
F+F + ++ + L + V D+D + LG + +PL C +L D LEQ F
Sbjct: 515 FSFFVHNVATERLHLKVLDDDQECA---LGMLEVPL---------CQILPYADLTLEQRF 562
Query: 617 K 617
+
Sbjct: 563 Q 563
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 69.7 bits (169), Expect = 1e-11
Identities = 73/271 (26%), Positives = 116/271 (42%), Gaps = 42/271 (15%)
Query: 359 SITLLEG-KNVSGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
+IT +G K + + + +V+L L + ++KTL + NP W E ++ +D
Sbjct: 146 TITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDE 205
Query: 413 MGI---LDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLMLVTLTP 469
I L I V +D +H E +G +V + L + L+ L
Sbjct: 206 DMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEKQLPV--------- 256
Query: 470 CAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGK 529
D +E K + +R + SLK L V +++ A L A D +G
Sbjct: 257 ---------------DKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGY 301
Query: 530 SDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTVFDEDGD 581
SDP+ L D + +T K LNPE+N+ F + IK LEVTV+D D
Sbjct: 302 SDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDIG 361
Query: 582 KPPDFLGKVAIPLLSIRDGQPNCY-VLKNKD 611
K DF+G V + + + + + + LKNKD
Sbjct: 362 KSNDFIGGVVLGIHAKGERLKHWFDCLKNKD 392
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/256 (23%), Positives = 102/256 (39%), Gaps = 40/256 (15%)
Query: 200 LKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIV----VLPIQ 251
+ + + L D G +DPYVK L + ++K + LNP W+E + +
Sbjct: 147 ITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDED 206
Query: 252 SLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLN 310
+ + LR+ V D D ++F+G V L L+ N T + LE
Sbjct: 207 MIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFNICLEK-------------- 252
Query: 311 LNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSG 370
L V + + K R +S SS +K L GI+ L + +G
Sbjct: 253 -QLPVDKTEDKSLEERGRILISLKYSS-----------QKQGLLVGIVRCAHLAAMDANG 300
Query: 371 GSMTEMFVQLKLG-DQRYKSKTLC--KSANPQWQEQFDFHYFSDRMG--ILDIEVWGKDN 425
S + L+ D++ K KT K+ NP++ E+F + + L++ VW D
Sbjct: 301 YSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVWDYDI 360
Query: 426 KKHEERLGTCKVDISA 441
K + +G + I A
Sbjct: 361 GKSNDFIGGVVLGIHA 376
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 67.4 bits (163), Expect = 6e-11
Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 4/142 (2%)
Query: 487 SERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTH 546
+E+K+ + Y +++ + +G L V V++ +L GKS+P+C + +G+ T
Sbjct: 1576 TEKKKREKAYLVRS--QRATGIGRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITK 1633
Query: 547 TVYKNLNPEWNKVFTFPIKDI-HDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ-PNC 604
T+ LNP+WN F I+D+ +VL +TVF+ D P DFLG+ I + I+ Q
Sbjct: 1634 TIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKG 1693
Query: 605 YVLKNKDLEQAFKGVIYLEMDL 626
V K L + G I + +DL
Sbjct: 1694 PVTKCLLLHEVPTGEIVVRLDL 1715
Score = 39.3 bits (90), Expect = 0.016
Identities = 35/125 (28%), Positives = 63/125 (50%), Gaps = 14/125 (11%)
Query: 196 LTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQ 255
L +++ EG L G S+PY + + G + +K I LNP W+ I+ L+Q
Sbjct: 1598 LMVNVVEGIELKPCRSHGKSNPYCEVTM-GSQCHITKTIQDTLNPKWNSNCQFFIRDLEQ 1656
Query: 256 K-LRVKVYDRD-LTTSDFMGSAFVILSDLELNR-----TTEHILKLEDPNSLEDDMGVIV 308
+ L + V++RD + DF+G + ++D++ ++ T+ +L E P G IV
Sbjct: 1657 EVLCITVFERDQFSPDDFLGRTEIRVADIKKDQGSKGPVTKCLLLHEVPT------GEIV 1710
Query: 309 LNLNL 313
+ L+L
Sbjct: 1711 VRLDL 1715
Score = 34.3 bits (77), Expect = 0.52
Identities = 23/106 (21%), Positives = 48/106 (45%), Gaps = 5/106 (4%)
Query: 356 GIISITLLEG---KNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDFHYFSDR 412
G + + ++EG K + + ++ +G Q + +KT+ + NP+W F
Sbjct: 1596 GRLMVNVVEGIELKPCRSHGKSNPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLE 1655
Query: 413 MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCL 458
+L I V+ +D ++ LG + +I +K+ + P+ CL
Sbjct: 1656 QEVLCITVFERDQFSPDDFLG--RTEIRVADIKKDQGSKGPVTKCL 1699
>gi|67763814 death-inducing-protein [Homo sapiens]
Length = 578
Score = 67.4 bits (163), Expect = 6e-11
Identities = 50/184 (27%), Positives = 86/184 (46%), Gaps = 6/184 (3%)
Query: 642 EKRFVEDSRKLSKKILSRDVDRVKRITMAIWNTMQFLKSCFQWESTLRSTIAFAVFLITV 701
E+ VE LS + L+ ++ R+KR + N ++ L + W S S IAF V++ V
Sbjct: 186 EENTVETEEPLSARRLTENMRRLKRGAKPVTNFVKNLSALSDWYSVYTSAIAFTVYMNAV 245
Query: 702 WNFELYMIPLALLLIFVYNFIRPVKGKVSSIQDSQESTDIDDEEDEDDKESEKKGLIERI 761
W+ + IPL L L + + + + IQ S + + + + E + E+
Sbjct: 246 WHG--WAIPLFLFLAILRLSLNYLIARGWRIQWSI----VPEVSEPVEPPKEDLTVSEKF 299
Query: 762 YMVQDIVSTVQNVLEEIASFGERIKNTFNWTVPFLSSLACLILAAATIILYFIPLRYIIL 821
+V D+ QN+ ++A E+IKN F W P ++ + L AA + F P R + L
Sbjct: 300 QLVLDVAQKAQNLFGKMADILEKIKNLFMWVQPEITQKLYVALWAAFLASCFFPYRLVGL 359
Query: 822 IWGI 825
G+
Sbjct: 360 AVGL 363
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 66.6 bits (161), Expect = 9e-11
Identities = 70/277 (25%), Positives = 118/277 (42%), Gaps = 26/277 (9%)
Query: 355 NGIISITLLEGKNVS---GGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDF 406
N + T+++ K + + + +V+L L + ++KTL + NP W E +
Sbjct: 406 NSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVY 465
Query: 407 HYFSD---RMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLM 463
H +D + L I V +D H E +G + + L Q + L+ +
Sbjct: 466 HGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRA 525
Query: 464 LVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLA 523
T + + V + D+ ER +I SL G L V +++ L A
Sbjct: 526 GTTGSARGMALYEEEQVERVGDIEERGKILV------SLMYSTQQGGLIVGIIRCVHLAA 579
Query: 524 ADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTV 575
D +G SDPF L L D + +T K LNPE+N+ F + IK L+++V
Sbjct: 580 MDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISV 639
Query: 576 FDEDGDKPPDFLGKVAIPLLSIRDGQPNCY-VLKNKD 611
+D D K D++G + + + + + Y LKNKD
Sbjct: 640 WDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKD 676
Score = 58.9 bits (141), Expect = 2e-08
Identities = 62/260 (23%), Positives = 117/260 (45%), Gaps = 34/260 (13%)
Query: 202 EGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVV---LPIQSLD 254
+ + L D G +DPYVK L + ++K + NP+W+E +V + + +
Sbjct: 415 KAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQ 474
Query: 255 QK-LRVKVYDRD-LTTSDFMGSAFVILSDLELNRTT------EHILKLEDPNSLEDDMGV 306
+K LR+ V D D ++F+G L L+ N+ E ++ ++ + G+
Sbjct: 475 RKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGM 534
Query: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
+ V + GD + R ++ S L S ++ L GII L
Sbjct: 535 ALYEEEQVERVGDIEE-----RGKILVS---------LMYSTQQGGLIVGIIRCVHLAAM 580
Query: 367 NVSGGS--MTEMFVQLKLGDQ-RYKSKTLCKSANPQWQEQF--DFHYFSDRMGILDIEVW 421
+ +G S +++++ +G + ++K++ K+ NP++ E+F D + LDI VW
Sbjct: 581 DANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVW 640
Query: 422 GKDNKKHEERLGTCKVDISA 441
D K + +G C++ ISA
Sbjct: 641 DYDIGKSNDYIGGCQLGISA 660
Score = 44.7 bits (104), Expect = 4e-04
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 484 ADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----- 538
A+ + + T L+ SL +D LQ ++KA L D +G +DP+ L L
Sbjct: 382 ANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGAS 441
Query: 539 GNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV----LEVTVFDEDGDKPPDFLGKVAIPL 594
+++L+T T+ NP WN+ + D+ L ++V DED +F+G+ L
Sbjct: 442 KSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSL 501
Query: 595 LSIRDGQ 601
++ Q
Sbjct: 502 KKLKPNQ 508
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 66.6 bits (161), Expect = 9e-11
Identities = 70/277 (25%), Positives = 118/277 (42%), Gaps = 26/277 (9%)
Query: 355 NGIISITLLEGKNVS---GGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDF 406
N + T+++ K + + + +V+L L + ++KTL + NP W E +
Sbjct: 402 NSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVY 461
Query: 407 HYFSD---RMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLDSCLGALLM 463
H +D + L I V +D H E +G + + L Q + L+ +
Sbjct: 462 HGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRA 521
Query: 464 LVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLA 523
T + + V + D+ ER +I SL G L V +++ L A
Sbjct: 522 GTTGSARGMALYEEEQVERVGDIEERGKILV------SLMYSTQQGGLIVGIIRCVHLAA 575
Query: 524 ADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIKD---IHDVLEVTV 575
D +G SDPF L L D + +T K LNPE+N+ F + IK L+++V
Sbjct: 576 MDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISV 635
Query: 576 FDEDGDKPPDFLGKVAIPLLSIRDGQPNCY-VLKNKD 611
+D D K D++G + + + + + Y LKNKD
Sbjct: 636 WDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKD 672
Score = 58.9 bits (141), Expect = 2e-08
Identities = 62/260 (23%), Positives = 117/260 (45%), Gaps = 34/260 (13%)
Query: 202 EGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVV---LPIQSLD 254
+ + L D G +DPYVK L + ++K + NP+W+E +V + + +
Sbjct: 411 KAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQ 470
Query: 255 QK-LRVKVYDRD-LTTSDFMGSAFVILSDLELNRTT------EHILKLEDPNSLEDDMGV 306
+K LR+ V D D ++F+G L L+ N+ E ++ ++ + G+
Sbjct: 471 RKTLRISVCDEDKFGHNEFIGETRFSLKKLKPNQRKNFNICLERVIPMKRAGTTGSARGM 530
Query: 307 IVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGK 366
+ V + GD + R ++ S L S ++ L GII L
Sbjct: 531 ALYEEEQVERVGDIEE-----RGKILVS---------LMYSTQQGGLIVGIIRCVHLAAM 576
Query: 367 NVSGGS--MTEMFVQLKLGDQ-RYKSKTLCKSANPQWQEQF--DFHYFSDRMGILDIEVW 421
+ +G S +++++ +G + ++K++ K+ NP++ E+F D + LDI VW
Sbjct: 577 DANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKSLDISVW 636
Query: 422 GKDNKKHEERLGTCKVDISA 441
D K + +G C++ ISA
Sbjct: 637 DYDIGKSNDYIGGCQLGISA 656
Score = 44.7 bits (104), Expect = 4e-04
Identities = 34/127 (26%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 484 ADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----- 538
A+ + + T L+ SL +D LQ ++KA L D +G +DP+ L L
Sbjct: 378 ANSYDSDEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGAS 437
Query: 539 GNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV----LEVTVFDEDGDKPPDFLGKVAIPL 594
+++L+T T+ NP WN+ + D+ L ++V DED +F+G+ L
Sbjct: 438 KSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHNEFIGETRFSL 497
Query: 595 LSIRDGQ 601
++ Q
Sbjct: 498 KKLKPNQ 504
>gi|122937514 unc-13 homolog C [Homo sapiens]
Length = 2214
Score = 65.9 bits (159), Expect = 2e-10
Identities = 36/127 (28%), Positives = 68/127 (53%), Gaps = 11/127 (8%)
Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570
+ + V+ A L A D +G SDP+ +++G ++ +T T++ NLNP W++ F F + D
Sbjct: 1222 ITITVVSAQGLQAKDKTGSSDPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFECHNSTDR 1281
Query: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619
++V V+DED D + DFLG+ + + ++ Y L+ + + A G
Sbjct: 1282 IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTDKSAVSGA 1341
Query: 620 IYLEMDL 626
I L++++
Sbjct: 1342 IRLKINV 1348
Score = 57.8 bits (138), Expect = 4e-08
Identities = 39/139 (28%), Positives = 66/139 (47%), Gaps = 15/139 (10%)
Query: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249
S ++ +TI + + L +D+ G+SDPYV ++ GK ++K I+ NLNPVWDE
Sbjct: 1216 SKWSAKITITVVSAQGLQAKDKTGSSDPYVTVQV-GKNKRRTKTIFGNLNPVWDEKFYFE 1274
Query: 250 IQSLDQKLRVKVYDRD------------LTTSDFMGSAFVILSDLELNRTTEHILKLEDP 297
+ +++V+V+D D + DF+G V + L + L+
Sbjct: 1275 CHNSTDRIKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTLSGEMDVWYNLEKRTD 1334
Query: 298 NSLEDDMGVIVLNLNLVVK 316
S G I L +N+ +K
Sbjct: 1335 KSAVS--GAIRLKINVEIK 1351
Score = 40.8 bits (94), Expect = 0.006
Identities = 29/107 (27%), Positives = 56/107 (52%), Gaps = 23/107 (21%)
Query: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406
W+ I+IT+ L+ K+ +G S + +V +++G + ++KT+ + NP W E+F F
Sbjct: 1218 WSAKITITVVSAQGLQAKDKTGSS--DPYVTVQVGKNKRRTKTIFGNLNPVWDEKFYFEC 1275
Query: 407 HYFSDRMGILDIEVWGKDN-----------KKHEERLGTCKVDISAL 442
H +DR + + VW +D+ K+ ++ LG V++ L
Sbjct: 1276 HNSTDR---IKVRVWDEDDDIKSRVKQHFKKESDDFLGQTIVEVRTL 1319
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/132 (36%), Positives = 64/132 (48%), Gaps = 7/132 (5%)
Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGND---RLQTHTVYKNLNPEWNKVFTFP---- 563
L VK++KA +L A DFSG SDPF + L D +L+T KNLNP WN+ F F
Sbjct: 152 LTVKIMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPY 211
Query: 564 IKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLE 623
K + +L + V D D D +G+V+IPL + Q + K L
Sbjct: 212 EKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELL 271
Query: 624 MDLIYNPVKASI 635
+ L YNP SI
Sbjct: 272 LSLCYNPSANSI 283
Score = 55.8 bits (133), Expect = 2e-07
Identities = 81/323 (25%), Positives = 130/323 (40%), Gaps = 60/323 (18%)
Query: 283 ELNRTTEHILKLED-PNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRN 341
E +R TE + D NSL +M L L + + H +R+ L + S+ N
Sbjct: 93 ESDRRTEPRSSVSDLVNSLTSEM------LMLSPGSEEDEAHEGCSRENLGRIQFSVGYN 146
Query: 342 LRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQLKL-GDQRYKSKTLCK--SANP 398
+ S K I+ L K+ SG S + FV++ L D+++K +T K + NP
Sbjct: 147 FQESTLTVK------IMKAQELPAKDFSGTS--DPFVKIYLLPDKKHKLETKVKRKNLNP 198
Query: 399 QWQEQFDFHYFSDR---MGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCLELPLD 455
W E F F F IL ++V D + +G + ++ + L Q L
Sbjct: 199 HWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLK 258
Query: 456 SCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKV 515
C + G + LC P A+ + V +
Sbjct: 259 PCSDG-------SGSRGELLLSLCYNPSANS------------------------IIVNI 287
Query: 516 LKAADLLAADFSGKSDPFCLLEL-----GNDRLQTHTVYKNLNPEWNKVFTFPI---KDI 567
+KA +L A D G SDP+ + L ++ +T T+ +NLNP +N+ F F I K
Sbjct: 288 IKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLR 347
Query: 568 HDVLEVTVFDEDGDKPPDFLGKV 590
+ +TV D+D D +GK+
Sbjct: 348 ETTIIITVMDKDKLSRNDVIGKI 370
Score = 54.7 bits (130), Expect = 4e-07
Identities = 72/298 (24%), Positives = 128/298 (42%), Gaps = 59/298 (19%)
Query: 161 SDLNASMTSQHF-------EEQSVPGEASDGLSNLPSPFAY-----LLTIHLKEGRNLVV 208
SDL S+TS+ E+++ G + + L + Y LT+ + + + L
Sbjct: 105 SDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPA 164
Query: 209 RDRCGTSDPYVKFKL--NGKTLYKSKVIYKNLNPVWDEIVV---LPIQSLDQK---LRVK 260
+D GTSDP+VK L + K ++KV KNLNP W+E + P + + Q+ L+V
Sbjct: 165 KDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVL 224
Query: 261 VYDRDLTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLVVKQGDF 320
YDR + +D +G + L+ ++L + L+ + G ++L+L
Sbjct: 225 DYDR-FSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSL--------- 274
Query: 321 KRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQL 380
+ S +S+I N II L+ ++ G S + V L
Sbjct: 275 ---------CYNPSANSIIVN---------------IIKARNLKAMDIGGTSDPYVKVWL 310
Query: 381 KLGDQRYKSK---TLCKSANPQWQEQFDFHYFSDRM--GILDIEVWGKDNKKHEERLG 433
D+R + K T+ ++ NP + E F F ++++ + I V KD + +G
Sbjct: 311 MYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIG 368
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/103 (33%), Positives = 56/103 (54%), Gaps = 12/103 (11%)
Query: 185 LSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKL--NGKTLYKSKVI--YKNLNP 240
LS +P A + +++ + RNL D GTSDPYVK L K + K K + +NLNP
Sbjct: 272 LSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNP 331
Query: 241 VWDEIVVLPIQSLDQKLR-----VKVYDRD-LTTSDFMGSAFV 277
+++E I + +KLR + V D+D L+ +D +G ++
Sbjct: 332 IFNESFAFDIPT--EKLRETTIIITVMDKDKLSRNDVIGKIYL 372
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 65.1 bits (157), Expect = 3e-10
Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 15/137 (10%)
Query: 503 KDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPE 555
+D + IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+
Sbjct: 14 EDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPK 73
Query: 556 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 607
WN+ F F + + L VFDE+ DFLG+V +PL + P ++L
Sbjct: 74 WNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133
Query: 608 KNKDLEQAFKGVIYLEM 624
+ + + KG + L+M
Sbjct: 134 RPRSHKSRVKGFLRLKM 150
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
+L + + G +L +D G SDPYVK L L ++K I K LNP W+E
Sbjct: 21 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 80
Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
+ + +L +V+D + LT DF+G V LS L T +E P + +D
Sbjct: 81 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 130
Score = 36.2 bits (82), Expect = 0.14
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
++S L K++ G S + + L + D+ ++KT+ K+ NP+W E+F F
Sbjct: 26 VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 85
Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
+L EV+ ++ ++ LG V +S LP
Sbjct: 86 NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 116
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 65.1 bits (157), Expect = 3e-10
Identities = 46/137 (33%), Positives = 67/137 (48%), Gaps = 15/137 (10%)
Query: 503 KDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPE 555
+D + IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+
Sbjct: 14 EDEGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPK 73
Query: 556 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 607
WN+ F F + + L VFDE+ DFLG+V +PL + P ++L
Sbjct: 74 WNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLL 133
Query: 608 KNKDLEQAFKGVIYLEM 624
+ + + KG + L+M
Sbjct: 134 RPRSHKSRVKGFLRLKM 150
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
+L + + G +L +D G SDPYVK L L ++K I K LNP W+E
Sbjct: 21 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 80
Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
+ + +L +V+D + LT DF+G V LS L T +E P + +D
Sbjct: 81 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 130
Score = 36.2 bits (82), Expect = 0.14
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
++S L K++ G S + + L + D+ ++KT+ K+ NP+W E+F F
Sbjct: 26 VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 85
Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
+L EV+ ++ ++ LG V +S LP
Sbjct: 86 NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 116
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 15/130 (11%)
Query: 510 ILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPEWNKVFTF 562
IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+WN+ F F
Sbjct: 13 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72
Query: 563 PIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVLKNKDLEQ 614
+ + L VFDE+ DFLG+V +PL + P ++L+ + +
Sbjct: 73 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKS 132
Query: 615 AFKGVIYLEM 624
KG + L+M
Sbjct: 133 RVKGFLRLKM 142
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
+L + + G +L +D G SDPYVK L L ++K I K LNP W+E
Sbjct: 13 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72
Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
+ + +L +V+D + LT DF+G V LS L T +E P + +D
Sbjct: 73 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 122
Score = 36.2 bits (82), Expect = 0.14
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
++S L K++ G S + + L + D+ ++KT+ K+ NP+W E+F F
Sbjct: 18 VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 77
Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
+L EV+ ++ ++ LG V +S LP
Sbjct: 78 NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 108
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 64.7 bits (156), Expect = 4e-10
Identities = 45/130 (34%), Positives = 64/130 (49%), Gaps = 15/130 (11%)
Query: 510 ILQVKVLKAADLLAADFSGKSDPFCLLEL----GNDRL---QTHTVYKNLNPEWNKVFTF 562
IL+VKV+ DL D G SDP+ L L N L QT T+ K LNP+WN+ F F
Sbjct: 13 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72
Query: 563 PIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVLKNKDLEQ 614
+ + L VFDE+ DFLG+V +PL + P ++L+ + +
Sbjct: 73 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKS 132
Query: 615 AFKGVIYLEM 624
KG + L+M
Sbjct: 133 RVKGFLRLKM 142
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/115 (32%), Positives = 55/115 (47%), Gaps = 12/115 (10%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL------NGKTLYKSKVIYKNLNPVWDEIVVL 248
+L + + G +L +D G SDPYVK L L ++K I K LNP W+E
Sbjct: 13 ILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYF 72
Query: 249 PIQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
+ + +L +V+D + LT DF+G V LS L T +E P + +D
Sbjct: 73 RVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPT-----MERPYTFKD 122
Score = 36.2 bits (82), Expect = 0.14
Identities = 25/92 (27%), Positives = 46/92 (50%), Gaps = 6/92 (6%)
Query: 357 IISITLLEGKNVSGGSMTEMFVQLKLGDQR-----YKSKTLCKSANPQWQEQFDFHYFSD 411
++S L K++ G S + + L + D+ ++KT+ K+ NP+W E+F F
Sbjct: 18 VVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPS 77
Query: 412 RMGILDIEVWGKDNKKHEERLGTCKVDISALP 443
+L EV+ ++ ++ LG V +S LP
Sbjct: 78 NHRLL-FEVFDENRLTRDDFLGQVDVPLSHLP 108
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 64.3 bits (155), Expect = 5e-10
Identities = 38/127 (29%), Positives = 63/127 (49%), Gaps = 11/127 (8%)
Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570
+ + V+ A L A D +G SDP+ +++G + +T T+Y NLNP W + F F + D
Sbjct: 766 ISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDR 825
Query: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619
++V V+DED D + DFLG+ I + ++ Y L + + A G
Sbjct: 826 IKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGA 885
Query: 620 IYLEMDL 626
I L + +
Sbjct: 886 IRLHISV 892
Score = 54.7 bits (130), Expect = 4e-07
Identities = 27/76 (35%), Positives = 47/76 (61%), Gaps = 1/76 (1%)
Query: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249
S ++ ++I + + L +D+ G+SDPYV ++ GKT ++K IY NLNPVW+E
Sbjct: 760 SKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQV-GKTKKRTKTIYGNLNPVWEENFHFE 818
Query: 250 IQSLDQKLRVKVYDRD 265
+ +++V+V+D D
Sbjct: 819 CHNSSDRIKVRVWDED 834
Score = 43.5 bits (101), Expect = 9e-04
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 12/79 (15%)
Query: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406
W+ ISIT+ L+ K+ +G S + +V +++G + ++KT+ + NP W+E F F
Sbjct: 762 WSAKISITVVCAQGLQAKDKTGSS--DPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFEC 819
Query: 407 HYFSDRMGILDIEVWGKDN 425
H SDR + + VW +D+
Sbjct: 820 HNSSDR---IKVRVWDEDD 835
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 62.4 bits (150), Expect = 2e-09
Identities = 62/222 (27%), Positives = 96/222 (43%), Gaps = 21/222 (9%)
Query: 386 RYKSKTLCKSANPQWQEQFDFHYFSD---RMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
+ K+KT + NP W E + +D +L I V +D H E +G +V + L
Sbjct: 142 KLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRL 201
Query: 443 PLKQANCLELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQ----ITQRYCL 498
Q + L+ + G+S C L +L + +Q + +R +
Sbjct: 202 KPSQKKHFNICLERQVPLASPSSMSAALRGIS------CYLKELEQAEQGQGLLEERGRI 255
Query: 499 QNSLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLN 553
SL L V +L+ A L A D +G SDP+ L D + +T K LN
Sbjct: 256 LLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLN 315
Query: 554 PEWNKVFTFPIKD---IHDVLEVTVFDEDGDKPPDFLGKVAI 592
PE+N+ F + I+ LEVTV+D D K DF+G V++
Sbjct: 316 PEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSL 357
Score = 54.7 bits (130), Expect = 4e-07
Identities = 34/100 (34%), Positives = 52/100 (52%), Gaps = 9/100 (9%)
Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLEL-----GNDRLQTHTVYKNLNPEWNKVFTFP-I 564
L +L+A L DF+G +DP+ L L ++L+T T LNP WN+ T+ I
Sbjct: 106 LHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGI 165
Query: 565 KD---IHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQ 601
D H VL + V DED +F+G++ +PL ++ Q
Sbjct: 166 TDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQ 205
Score = 50.4 bits (119), Expect = 7e-06
Identities = 90/358 (25%), Positives = 146/358 (40%), Gaps = 43/358 (12%)
Query: 147 GGDAPEEPEKLC---GSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAY---LLTIH- 199
GG+AP L ++ L A+ E S + + L L Y T+H
Sbjct: 49 GGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHC 108
Query: 200 -LKEGRNLVVRDRCGTSDPYVKFKLNGKTL----YKSKVIYKNLNPVWDEIV----VLPI 250
+ + L D G +DPYVK L K+K LNPVW+E + +
Sbjct: 109 SILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDD 168
Query: 251 QSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLE------LNRTTEHILKLEDPNSLEDD 303
+ LR+ V D D L+ ++F+G V L L+ N E + L P+S+
Sbjct: 169 DITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAA 228
Query: 304 MGVIVLNLNLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLL 363
+ I L ++Q + + R R+ L LS S ++ L GI+ L
Sbjct: 229 LRGISCYLK-ELEQAEQGQGLLEERGRIL---------LSLSYSSRRRGLLVGILRCAHL 278
Query: 364 EGKNVSGGSMTEMFVQLKLG-DQRYKSKTLC--KSANPQWQEQFDFHYFSDRMG--ILDI 418
+V+G S + L+ D++ K KT K+ NP++ E+F + + L++
Sbjct: 279 AAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEV 338
Query: 419 EVWGKDNKKHEERLGTCKVDISALPLKQ---ANCLELPLDSCLGALLMLVT-LTPCAG 472
VW D K + +G + A + ++CL+ P D+ L L + L P AG
Sbjct: 339 TVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQP-DAALERWHTLTSELPPAAG 395
>gi|110611226 UNC13 (C. elegans)-like [Homo sapiens]
Length = 1591
Score = 62.0 bits (149), Expect = 2e-09
Identities = 36/127 (28%), Positives = 64/127 (50%), Gaps = 11/127 (8%)
Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKDIHDV 570
+ + V+ A L A D +G SDP+ +++ + +T T++ NLNP W + F F + D
Sbjct: 602 ITITVVCAQGLQAKDKTGSSDPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFECHNSSDR 661
Query: 571 LEVTVFDEDGD-----------KPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGV 619
++V V+DED D + DFLG+ I + ++ Y L+ + + A G
Sbjct: 662 IKVRVWDEDDDIKSRVKQRLKRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGA 721
Query: 620 IYLEMDL 626
I L++ +
Sbjct: 722 IRLQISV 728
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/76 (34%), Positives = 47/76 (61%), Gaps = 1/76 (1%)
Query: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKLNGKTLYKSKVIYKNLNPVWDEIVVLP 249
S ++ +TI + + L +D+ G+SDPYV +++ KT ++K I+ NLNPVW+E
Sbjct: 596 SKWSAKITITVVCAQGLQAKDKTGSSDPYVTVQVS-KTKKRTKTIFGNLNPVWEEKFHFE 654
Query: 250 IQSLDQKLRVKVYDRD 265
+ +++V+V+D D
Sbjct: 655 CHNSSDRIKVRVWDED 670
Score = 40.4 bits (93), Expect = 0.007
Identities = 24/79 (30%), Positives = 46/79 (58%), Gaps = 12/79 (15%)
Query: 354 WNGIISITL-----LEGKNVSGGSMTEMFVQLKLGDQRYKSKTLCKSANPQWQEQFDF-- 406
W+ I+IT+ L+ K+ +G S + +V +++ + ++KT+ + NP W+E+F F
Sbjct: 598 WSAKITITVVCAQGLQAKDKTGSS--DPYVTVQVSKTKKRTKTIFGNLNPVWEEKFHFEC 655
Query: 407 HYFSDRMGILDIEVWGKDN 425
H SDR + + VW +D+
Sbjct: 656 HNSSDR---IKVRVWDEDD 671
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 61.6 bits (148), Expect = 3e-09
Identities = 83/315 (26%), Positives = 130/315 (41%), Gaps = 72/315 (22%)
Query: 142 QKTSLGGDAPEEPEKLCGSSDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLLTIHLK 201
QK+ G DA E K CG +N S+ + E L + +
Sbjct: 129 QKSVDGEDAKSEATKSCGK--INFSLRYDYETET--------------------LIVRIL 166
Query: 202 EGRNLVVRDRCGTSDPYVKFKL--NGKTLYKSKVIYKNLNPVWDEIVVLPI---QSLDQK 256
+ +L +D CG+SDPYVK L + K +++V K LNP +DE P+ + D+K
Sbjct: 167 KAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHFPVPYEELADRK 226
Query: 257 LRVKVYDRD-LTTSDFMGSAFVILSDL----ELNRTTEHILKLEDPNSLEDDMGVIVLNL 311
L + V+D D + D +G VIL +L +L+R T ++ S D+G I+ +L
Sbjct: 227 LHLSVFDFDRFSRHDMIGE--VILDNLFEASDLSRETSIWKDIQYATSESVDLGEIMFSL 284
Query: 312 NLVVKQGDFKRHRWSNRKRLSASKSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGG 371
+ G RL+ + +I L+ +++G
Sbjct: 285 CYLPTAG-----------RLTLT----------------------VIKCRNLKAMDITGY 311
Query: 372 SMTEMFVQLKLGDQRYKSK--TLCKSA-NPQWQEQFDFHYFSDRMG--ILDIEVWGKDNK 426
S + V L +R K K T+ K+ NP + E F + M L I V D
Sbjct: 312 SDPYVKVSLLCDGRRLKKKKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRV 371
Query: 427 KHEERLGTCKVDISA 441
H E +G C+V I+A
Sbjct: 372 GHNEIIGVCRVGITA 386
Score = 54.3 bits (129), Expect = 5e-07
Identities = 38/98 (38%), Positives = 56/98 (57%), Gaps = 6/98 (6%)
Query: 501 SLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDR---LQTHTVYKNLNPEWN 557
SL+ + L V++LKA DL A DF G SDP+ + L DR LQT K LNP ++
Sbjct: 151 SLRYDYETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFD 210
Query: 558 KVFTFPI--KDIHD-VLEVTVFDEDGDKPPDFLGKVAI 592
+ F FP+ +++ D L ++VFD D D +G+V +
Sbjct: 211 ENFHFPVPYEELADRKLHLSVFDFDRFSRHDMIGEVIL 248
Score = 35.0 bits (79), Expect = 0.31
Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 8/87 (9%)
Query: 501 SLKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGND----RLQTHTVYKN-LNPE 555
SL + G L + V+K +L A D +G SDP+ + L D + + T+ KN LNP
Sbjct: 283 SLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIKKNTLNPV 342
Query: 556 WNK--VFTFPIKDIHDV-LEVTVFDED 579
+N+ +F P +++ V L ++V D D
Sbjct: 343 YNEAIIFDIPPENMDQVSLLISVMDYD 369
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 60.5 bits (145), Expect = 7e-09
Identities = 43/143 (30%), Positives = 68/143 (47%), Gaps = 16/143 (11%)
Query: 502 LKDVKDVGILQVKVLKAADLLAADFSGKSDPFCLLELGNDR------LQTHTVYKNLNPE 555
L+D ++ I++V+V+ L D G SDP+ + L + +QT T+ K+LNP+
Sbjct: 12 LEDEENSRIVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPK 71
Query: 556 WNKVFTFPIKDIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNC--------YVL 607
WN+ F + L VFDE+ DFLG+V +PL + P +VL
Sbjct: 72 WNEEILFRVHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENPRLERPYTFKDFVL 131
Query: 608 KNKDLEQAFKGVIYLEMDLIYNP 630
+ + KG YL + + Y P
Sbjct: 132 HPRSHKSRVKG--YLRLKMTYLP 152
Score = 50.8 bits (120), Expect = 5e-06
Identities = 36/114 (31%), Positives = 57/114 (50%), Gaps = 11/114 (9%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGK-TLYKSKVIYKNLNPVWDEIVVLP 249
++ + + G L +D G SDPYV+ L NG T ++K I K+LNP W+E ++
Sbjct: 20 IVRVRVIAGIGLAKKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFR 79
Query: 250 IQSLDQKLRVKVYDRD-LTTSDFMGSAFVILSDLELNRTTEHILKLEDPNSLED 302
+ +L +V+D + LT DF+G V L L +LE P + +D
Sbjct: 80 VHPQQHRLLFEVFDENRLTRDDFLGQVDVPLYPLPTENP-----RLERPYTFKD 128
Score = 32.3 bits (72), Expect = 2.0
Identities = 19/61 (31%), Positives = 33/61 (54%), Gaps = 3/61 (4%)
Query: 388 KSKTLCKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQA 447
++KT+ KS NP+W E+ F + +L EV+ ++ ++ LG +VD+ PL
Sbjct: 60 QTKTIKKSLNPKWNEEILFRVHPQQHRLL-FEVFDENRLTRDDFLG--QVDVPLYPLPTE 116
Query: 448 N 448
N
Sbjct: 117 N 117
>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
Length = 671
Score = 59.3 bits (142), Expect = 2e-08
Identities = 36/96 (37%), Positives = 59/96 (61%), Gaps = 7/96 (7%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVVLPI 250
+L + +++ +NLV D G SDPYVK KL ++ K+K I +LNP W+E +
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231
Query: 251 Q--SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDLE 283
+ D++L V+++D DLT+ +DFMGS +S+L+
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/99 (33%), Positives = 53/99 (53%), Gaps = 7/99 (7%)
Query: 507 DVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFT 561
D +L V V A +L+ D +G SDP+ L+L D + +T T+ +LNPEWN+ F
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228
Query: 562 FPIK--DIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIR 598
F +K D L V ++D D DF+G ++ + ++
Sbjct: 229 FQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 9/95 (9%)
Query: 357 IISITLLEGKNV---SGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHY 408
++ + + + KN+ +++ +V+LKL + + K+KT+ S NP+W E F F
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231
Query: 409 -FSDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
SD+ L +E+W D + +G+ IS L
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266
>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
Length = 673
Score = 59.3 bits (142), Expect = 2e-08
Identities = 36/96 (37%), Positives = 59/96 (61%), Gaps = 7/96 (7%)
Query: 195 LLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVVLPI 250
+L + +++ +NLV D G SDPYVK KL ++ K+K I +LNP W+E +
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231
Query: 251 Q--SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDLE 283
+ D++L V+++D DLT+ +DFMGS +S+L+
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/99 (33%), Positives = 53/99 (53%), Gaps = 7/99 (7%)
Query: 507 DVGILQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFT 561
D +L V V A +L+ D +G SDP+ L+L D + +T T+ +LNPEWN+ F
Sbjct: 169 DRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFR 228
Query: 562 FPIK--DIHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIR 598
F +K D L V ++D D DF+G ++ + ++
Sbjct: 229 FQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQ 267
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 9/95 (9%)
Query: 357 IISITLLEGKNV---SGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHY 408
++ + + + KN+ +++ +V+LKL + + K+KT+ S NP+W E F F
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231
Query: 409 -FSDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
SD+ L +E+W D + +G+ IS L
Sbjct: 232 KESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISEL 266
>gi|13384594 protein kinase C, gamma [Homo sapiens]
Length = 697
Score = 59.3 bits (142), Expect = 2e-08
Identities = 37/100 (37%), Positives = 59/100 (59%), Gaps = 7/100 (7%)
Query: 190 SPFAYLLTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEI 245
+P A + + + E RNL+ D G SDPYVK KL T K++ + LNPVW+E
Sbjct: 167 APTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNET 226
Query: 246 VVLPIQ--SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDL 282
V ++ ++++L V+V+D D T+ +DFMG+ +S+L
Sbjct: 227 FVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL 266
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 8/129 (6%)
Query: 470 CAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDVGILQVKVLKAADLLAADFSGK 529
C ++V CV + L +R LQ ++ + V V +A +L+ D +G
Sbjct: 133 CCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIR-APTADEIHVTVGEARNLIPMDPNGL 191
Query: 530 SDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIK--DIHDVLEVTVFDEDGDK 582
SDP+ L+L D + +T TV LNP WN+ F F +K D+ L V V+D D
Sbjct: 192 SDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTS 251
Query: 583 PPDFLGKVA 591
DF+G ++
Sbjct: 252 RNDFMGAMS 260
Score = 34.7 bits (78), Expect = 0.40
Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 9/94 (9%)
Query: 358 ISITLLEGKNV---SGGSMTEMFVQLKLGDQ-----RYKSKTLCKSANPQWQEQFDFHYF 409
I +T+ E +N+ +++ +V+LKL + K++T+ + NP W E F F+
Sbjct: 173 IHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLK 232
Query: 410 -SDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
D L +EVW D + +G +S L
Sbjct: 233 PGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSEL 266
>gi|4506067 protein kinase C, alpha [Homo sapiens]
Length = 672
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/94 (37%), Positives = 55/94 (58%), Gaps = 7/94 (7%)
Query: 196 LTIHLKEGRNLVVRDRCGTSDPYVKFKL----NGKTLYKSKVIYKNLNPVWDEIVVLPIQ 251
L + +++ +NL+ D G SDPYVK KL ++ K+K I LNP W+E ++
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232
Query: 252 --SLDQKLRVKVYDRDLTT-SDFMGSAFVILSDL 282
D++L V+++D D TT +DFMGS +S+L
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL 266
Score = 50.8 bits (120), Expect = 5e-06
Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 7/88 (7%)
Query: 511 LQVKVLKAADLLAADFSGKSDPFCLLELGND-----RLQTHTVYKNLNPEWNKVFTFPIK 565
L V V A +L+ D +G SDP+ L+L D + +T T+ LNP+WN+ FTF +K
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232
Query: 566 --DIHDVLEVTVFDEDGDKPPDFLGKVA 591
D L V ++D D DF+G ++
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLS 260
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 9/94 (9%)
Query: 358 ISITLLEGKNV---SGGSMTEMFVQLKL-----GDQRYKSKTLCKSANPQWQEQFDFHYF 409
+ +T+ + KN+ +++ +V+LKL + + K+KT+ + NPQW E F F
Sbjct: 173 LHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLK 232
Query: 410 -SDRMGILDIEVWGKDNKKHEERLGTCKVDISAL 442
SD+ L +E+W D + +G+ +S L
Sbjct: 233 PSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSEL 266
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,545,597
Number of Sequences: 37866
Number of extensions: 1464349
Number of successful extensions: 8466
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 117
Number of HSP's that attempted gapping in prelim test: 7562
Number of HSP's gapped (non-prelim): 830
length of query: 878
length of database: 18,247,518
effective HSP length: 111
effective length of query: 767
effective length of database: 14,044,392
effective search space: 10772048664
effective search space used: 10772048664
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.