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Search of human proteins with 22749129
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
(473 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 962 0.0
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 626 e-179
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 570 e-163
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 101 1e-21
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 92 8e-19
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 92 8e-19
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 92 8e-19
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 92 8e-19
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 91 2e-18
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 89 1e-17
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 89 1e-17
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 87 4e-17
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 87 4e-17
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 87 4e-17
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 86 6e-17
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 86 1e-16
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 84 2e-16
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 84 2e-16
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 83 6e-16
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 83 6e-16
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 82 8e-16
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 80 4e-15
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 79 9e-15
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 73 6e-13
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 73 6e-13
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 73 6e-13
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 73 6e-13
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 72 8e-13
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 72 1e-12
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 72 1e-12
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 962 bits (2487), Expect = 0.0
Identities = 473/473 (100%), Positives = 473/473 (100%)
Query: 1 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR 60
MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR
Sbjct: 1 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR 60
Query: 61 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET 120
TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET
Sbjct: 61 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET 120
Query: 121 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST 180
FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST
Sbjct: 121 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST 180
Query: 181 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD 240
STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD
Sbjct: 181 STDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLD 240
Query: 241 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG 300
NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG
Sbjct: 241 NDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIG 300
Query: 301 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL 360
NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL
Sbjct: 301 NFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSL 360
Query: 361 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC 420
TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC
Sbjct: 361 TAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC 420
Query: 421 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV 473
PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV
Sbjct: 421 PFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGRV 473
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 626 bits (1615), Expect = e-179
Identities = 321/473 (67%), Positives = 368/473 (77%), Gaps = 9/473 (1%)
Query: 1 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR 60
MPQT S M + + + G D S SLE LIQHLVP DYYP++
Sbjct: 1 MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEK 60
Query: 61 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET 120
YIFTFLLSSRLF+ P EL+A+VCHLC+E Q+L P DK ++RK PK+LQLL EWTET
Sbjct: 61 AYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTET 120
Query: 121 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST 180
FP DF++E + +LKD+ RIA +E YRK + Q++Q L +KLAAL Q E L
Sbjct: 121 FPRDFQEESTIGHLKDVVGRIAPCDE-AYRKRMHQLLQALHQKLAALRQGPEGLV----- 174
Query: 181 STDRLTVLKTKPQ-SIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPL 239
D+ +TKP SI R+++ VC+DPYTLAQQLTH+ELERL +IGPEEFVQAFV KDPL
Sbjct: 175 GADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPL 234
Query: 240 DNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNI 299
+ K C+S+ KT NLEAYV+WFNRL YLVATEICMP KKK RA++IE+FIDVARECFNI
Sbjct: 235 ASTKPCFSD--KTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNI 292
Query: 300 GNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRS 359
GNFNSLMAIISGMNMSPVSRLKKTWAKV+TAKF ILEHQMDP+ NF NYRTALRGAA RS
Sbjct: 293 GNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRS 352
Query: 360 LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVE 419
LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKF ELAKQV EF+TWKQVE
Sbjct: 353 LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVE 412
Query: 420 CPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGR 472
CPFE+D I YL T P+FSED LYLASYESE PEN EK+RWK+LRSS+LG+
Sbjct: 413 CPFEQDASITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSILGK 465
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 570 bits (1470), Expect = e-163
Identities = 274/446 (61%), Positives = 352/446 (78%), Gaps = 3/446 (0%)
Query: 29 GGLYYHDNNLLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCV 88
G L + D +L+SGSLEAL++HLVP VDYYPDRTYIFTFLLSSR+FM P++L+A+V +CV
Sbjct: 36 GDLIFQDGHLISGSLEALMEHLVPTVDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICV 95
Query: 89 EHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQ- 147
E ++ + +K +++ + KI+QLL EWTE FPYDF+DE+ M LK + HR+ +E+
Sbjct: 96 EQKQQLEAGPEKAKLKSFSAKIVQLLKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEEN 155
Query: 148 -TYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDP 206
T +K + QM Q L+ LAA SQ +E+ K+ + D+ +LKTKP + Q+DI+ VC DP
Sbjct: 156 GTVKKAIAQMTQSLLLSLAARSQLQELREKLRPPAVDKGPILKTKPPAAQKDILGVCCDP 215
Query: 207 YTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLS 266
LAQQLTHIEL+R++ I PE+ +Q D LDN + C + KT +LEAY WFN LS
Sbjct: 216 LVLAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLS 274
Query: 267 YLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAK 326
LVATE+C VKKKHR RM+E+FIDVARECFNIGNFNS+MAIISGMN+SPV+RLKKTW+K
Sbjct: 275 MLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSK 334
Query: 327 VKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNE 386
VKTAKFD+LEH MDPSSNF NYRTAL+GA QRS A+SSREKIVIP F+L +KDIYFL++
Sbjct: 335 VKTAKFDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
Query: 387 GCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVFSEDALYLA 446
N LPNGH+NF+KFWE+++Q+ EFMTW QVECPFE+D+KI YLLT P++SE+AL++A
Sbjct: 395 IHTNHLPNGHINFKKFWEISRQIHEFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVA 454
Query: 447 SYESEGPENHIEKDRWKSLRSSLLGR 472
S+ESEGPENH+EKD WK+LR++LL R
Sbjct: 455 SFESEGPENHMEKDSWKTLRTTLLNR 480
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 101 bits (252), Expect = 1e-21
Identities = 67/204 (32%), Positives = 107/204 (52%), Gaps = 23/204 (11%)
Query: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
+A QL+ E I P E++ + L + SC NL+ + E N+ ++
Sbjct: 721 VATQLSMRNFELFRNIEPTEYIDDLFK---LRSKTSC-------ANLKRFEEVINQETFW 770
Query: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVK 328
VA+EI + R ++I++FI +A C NFNS+ AIISG+N++PV+RL+ TW K+
Sbjct: 771 VASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLP 830
Query: 329 T---AKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
F L+ DPS N YR L + + +IP F ++ KD+ FL+
Sbjct: 831 NKYEKLFQDLQDLFDPSRNMAKYRNVLNS---------QNLQPPIIPLFPVIKKDLTFLH 881
Query: 386 EGCANRLPNGHVNFEKFWELAKQV 409
EG +++ +G VNFEK +AK++
Sbjct: 882 EGNDSKV-DGLVNFEKLRMIAKEI 904
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/250 (29%), Positives = 120/250 (48%), Gaps = 30/250 (12%)
Query: 209 LAQQLT---HIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRL 265
+A+QLT H+ +++ Y E F Q +++ + N+++ Y K T++ FN +
Sbjct: 1026 IAEQLTLLDHLVFKKIPY--EEFFGQGWMKLEK--NERTPYI-MKTTKH-------FNDI 1073
Query: 266 SYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 325
S L+A+EI R IE ++ VA C + N+N+++ I S MN S + RLKKTW
Sbjct: 1074 SNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWL 1133
Query: 326 KVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIY 382
KV A D L+ + F N R AL+ + +P+ + + D+
Sbjct: 1134 KVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYLTDLA 1182
Query: 383 FLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSED 441
F+ EG N +G VNF K ++ + E ++Q E K+ QYLL V E+
Sbjct: 1183 FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE 1242
Query: 442 ALYLASYESE 451
+LY +S E
Sbjct: 1243 SLYESSLRIE 1252
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/250 (29%), Positives = 120/250 (48%), Gaps = 30/250 (12%)
Query: 209 LAQQLT---HIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRL 265
+A+QLT H+ +++ Y E F Q +++ + N+++ Y K T++ FN +
Sbjct: 1042 IAEQLTLLDHLVFKKIPY--EEFFGQGWMKLEK--NERTPYI-MKTTKH-------FNDI 1089
Query: 266 SYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 325
S L+A+EI R IE ++ VA C + N+N+++ I S MN S + RLKKTW
Sbjct: 1090 SNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWL 1149
Query: 326 KVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIY 382
KV A D L+ + F N R AL+ + +P+ + + D+
Sbjct: 1150 KVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYLTDLA 1198
Query: 383 FLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSED 441
F+ EG N +G VNF K ++ + E ++Q E K+ QYLL V E+
Sbjct: 1199 FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE 1258
Query: 442 ALYLASYESE 451
+LY +S E
Sbjct: 1259 SLYESSLRIE 1268
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 92.4 bits (228), Expect = 8e-19
Identities = 74/250 (29%), Positives = 120/250 (48%), Gaps = 30/250 (12%)
Query: 209 LAQQLT---HIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRL 265
+A+QLT H+ +++ Y E F Q +++ + N+++ Y K T++ FN +
Sbjct: 258 IAEQLTLLDHLVFKKIPY--EEFFGQGWMKLEK--NERTPYI-MKTTKH-------FNDI 305
Query: 266 SYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWA 325
S L+A+EI R IE ++ VA C + N+N+++ I S MN S + RLKKTW
Sbjct: 306 SNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWL 365
Query: 326 KVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIY 382
KV A D L+ + F N R AL+ + +P+ + + D+
Sbjct: 366 KVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVPYLGMYLTDLA 414
Query: 383 FLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSED 441
F+ EG N +G VNF K ++ + E ++Q E K+ QYLL V E+
Sbjct: 415 FIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEE 474
Query: 442 ALYLASYESE 451
+LY +S E
Sbjct: 475 SLYESSLRIE 484
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 92.4 bits (228), Expect = 8e-19
Identities = 72/248 (29%), Positives = 114/248 (45%), Gaps = 26/248 (10%)
Query: 209 LAQQLTHIELERLNYIGPEEFV-QAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSY 267
LA+Q+T ++ I EEF+ Q +++ D N+++ Y + + FN +S
Sbjct: 1006 LAEQITLLDHVIFRSIPYEEFLGQGWMKLDK--NERTPYIMKTS--------QHFNDMSN 1055
Query: 268 LVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV 327
LVA++I RA IE ++ VA C + N+N ++ I S +N S + RLKKTWAKV
Sbjct: 1056 LVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKV 1115
Query: 328 K---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFL 384
A D L+ + F N R L+ +P+ + + D+ F+
Sbjct: 1116 SKQTKALMDKLQKTVSSEGRFKNLRETLKNC-----------NPPAVPYLGMYLTDLAFI 1164
Query: 385 NEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVP-VFSEDAL 443
EG N G VNF K ++ + E ++Q + K+ QYLL + ED L
Sbjct: 1165 EEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTL 1224
Query: 444 YLASYESE 451
Y S + E
Sbjct: 1225 YELSLKIE 1232
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 91.3 bits (225), Expect = 2e-18
Identities = 60/206 (29%), Positives = 108/206 (52%), Gaps = 23/206 (11%)
Query: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
+A QL+ + + I P E++ +D + + +L+ + + N+ ++
Sbjct: 864 VATQLSMRDFDLFRNIEPTEYI----------DDLFKLNSKTGNTHLKRFEDIVNQETFW 913
Query: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVK 328
VA+EI + R ++I++FI +A C NFNS+ AIISG+N++ V+RL+ TW K+
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 329 T---AKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
+ L+ DPS N YR L + S + +IP F ++ KD+ FL+
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNIL---------SSQSMQPPIIPLFPVVKKDMTFLH 1024
Query: 386 EGCANRLPNGHVNFEKFWELAKQVSE 411
EG +++ +G VNFEK ++K++ +
Sbjct: 1025 EGNDSKV-DGLVNFEKLRMISKEIRQ 1049
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 88.6 bits (218), Expect = 1e-17
Identities = 66/201 (32%), Positives = 97/201 (48%), Gaps = 24/201 (11%)
Query: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
LA Q+T + E N + E + + ++ +K T NL+ ++ FN + +
Sbjct: 632 LAYQMTIYDWELFNCVHELELIYHTFGR---------HNFKKTTANLDLFLRRFNEIQFW 682
Query: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV- 327
V TEIC+ + R ++++ FI +A C N NS AI+ G++ VSRL TW K+
Sbjct: 683 VVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLP 742
Query: 328 -KTAKFDI-LEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
K KF E MDPS N YR + + E +IPF LLIKD+ F +
Sbjct: 743 SKFKKFYAEFESLMDPSRNHRAYRLTV-----------AKLEPPLIPFMPLLIKDMTFTH 791
Query: 386 EGCANRLPNGHVNFEKFWELA 406
EG + N VNFEK +A
Sbjct: 792 EGNKTFIDN-LVNFEKMRMIA 811
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 88.6 bits (218), Expect = 1e-17
Identities = 66/201 (32%), Positives = 97/201 (48%), Gaps = 24/201 (11%)
Query: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
LA Q+T + E N + E + + ++ +K T NL+ ++ FN + +
Sbjct: 776 LAYQMTIYDWELFNCVHELELIYHTFGR---------HNFKKTTANLDLFLRRFNEIQFW 826
Query: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV- 327
V TEIC+ + R ++++ FI +A C N NS AI+ G++ VSRL TW K+
Sbjct: 827 VVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLP 886
Query: 328 -KTAKFDI-LEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
K KF E MDPS N YR + + E +IPF LLIKD+ F +
Sbjct: 887 SKFKKFYAEFESLMDPSRNHRAYRLTV-----------AKLEPPLIPFMPLLIKDMTFTH 935
Query: 386 EGCANRLPNGHVNFEKFWELA 406
EG + N VNFEK +A
Sbjct: 936 EGNKTFIDN-LVNFEKMRMIA 955
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 86.7 bits (213), Expect = 4e-17
Identities = 58/159 (36%), Positives = 84/159 (52%), Gaps = 15/159 (9%)
Query: 252 TRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISG 311
T NLE ++ FN L Y VATE+C+ RA+++ FI +A N NS A++ G
Sbjct: 659 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 718
Query: 312 MNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREK 368
++ S +SRL TW ++ K K + LE +DPS N YR AL +
Sbjct: 719 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 767
Query: 369 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAK 407
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 768 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 805
Score = 30.8 bits (68), Expect = 2.8
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 43 LEALIQHLVPNVDYY-PDRTYIFTFLLSSRLFMHPYELMAKVC-HLCVEHQRLSDPDSDK 100
LE L++ + P+ + P T++ FLL+ R+FM +L A + H VE S+ +
Sbjct: 355 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST 414
Query: 101 NQMRKIAPKILQLLTEWTETF 121
K +IL+L+++W +
Sbjct: 415 YVCNK-RQQILRLVSQWVALY 434
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 86.7 bits (213), Expect = 4e-17
Identities = 58/159 (36%), Positives = 84/159 (52%), Gaps = 15/159 (9%)
Query: 252 TRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISG 311
T NLE ++ FN L Y VATE+C+ RA+++ FI +A N NS A++ G
Sbjct: 659 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 718
Query: 312 MNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREK 368
++ S +SRL TW ++ K K + LE +DPS N YR AL +
Sbjct: 719 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 767
Query: 369 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAK 407
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 768 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 805
Score = 30.8 bits (68), Expect = 2.8
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 43 LEALIQHLVPNVDYY-PDRTYIFTFLLSSRLFMHPYELMAKVC-HLCVEHQRLSDPDSDK 100
LE L++ + P+ + P T++ FLL+ R+FM +L A + H VE S+ +
Sbjct: 355 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST 414
Query: 101 NQMRKIAPKILQLLTEWTETF 121
K +IL+L+++W +
Sbjct: 415 YVCNK-RQQILRLVSQWVALY 434
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 86.7 bits (213), Expect = 4e-17
Identities = 58/159 (36%), Positives = 84/159 (52%), Gaps = 15/159 (9%)
Query: 252 TRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISG 311
T NLE ++ FN L Y VATE+C+ RA+++ FI +A N NS A++ G
Sbjct: 701 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 760
Query: 312 MNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREK 368
++ S +SRL TW ++ K K + LE +DPS N YR AL +
Sbjct: 761 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 809
Query: 369 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAK 407
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 810 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 847
Score = 30.8 bits (68), Expect = 2.8
Identities = 23/81 (28%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 43 LEALIQHLVPNVDYY-PDRTYIFTFLLSSRLFMHPYELMAKVC-HLCVEHQRLSDPDSDK 100
LE L++ + P+ + P T++ FLL+ R+FM +L A + H VE S+ +
Sbjct: 397 LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERST 456
Query: 101 NQMRKIAPKILQLLTEWTETF 121
K +IL+L+++W +
Sbjct: 457 YVCNK-RQQILRLVSQWVALY 476
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 86.3 bits (212), Expect = 6e-17
Identities = 70/230 (30%), Positives = 104/230 (45%), Gaps = 24/230 (10%)
Query: 183 DRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDND 242
D L +S QR + + + + LA +L + + N I +E + +
Sbjct: 473 DTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQ----- 527
Query: 243 KSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNF 302
+ T NL ++ N + VATEI + + R ++++ FI +A C N
Sbjct: 528 ----GSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNL 583
Query: 303 NSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQRS 359
NS AI+ G+N + VSRL +TW K+ K K F LE DPS N YR A +
Sbjct: 584 NSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFK------ 637
Query: 360 LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQV 409
+ IPF LL+KD+ F++EG L N VNFEK +A V
Sbjct: 638 -----KMKPPKIPFMPLLLKDVTFIHEGNKTFLDN-LVNFEKLHMIADTV 681
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 85.5 bits (210), Expect = 1e-16
Identities = 112/451 (24%), Positives = 186/451 (41%), Gaps = 64/451 (14%)
Query: 38 LLSGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPD 97
L +G+LEAL++HL+ D +++ FL + R F L+ + + S P
Sbjct: 92 LRAGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMADRLEALE--SHPT 149
Query: 98 SDKNQMRKIAPKILQLLTEWTETFPYDFRDERMMRNLKDLAHRIASGEEQT---YRKNVQ 154
+ + ++A + +L+ W + P DF E K R+ S QT K V
Sbjct: 150 DELERTTEVA---ISVLSTWLASHPEDFGSEA-----KGQLDRLESFLLQTGYAAGKGVG 201
Query: 155 QMMQCLIRKLAALSQYEEVLAKISSTSTD--RLTVLKTKPQSIQRDIITVCNDPYTLAQQ 212
LIR L + ++ + D + L P + D++ D LA+Q
Sbjct: 202 GGSADLIRNLRS---------RVDPQAPDLPKPLALPGDPPADPTDVLVFLADH--LAEQ 250
Query: 213 LTHIELER-LNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVAT 271
LT ++ E LN I + + +D + C S R A V FN+++ V +
Sbjct: 251 LTLLDAELFLNLIPSQCLGGLWGHRDRPGHSHLCPSVR-------ATVTQFNKVAGAVVS 303
Query: 272 EIC--------------MPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPV 317
+ P++ RAR++E +I VA EC + NF+S+ A++S + SP+
Sbjct: 304 SVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPI 363
Query: 318 SRLKKTWAKV---KTAKFDILEHQMDPSSNFYNYRTAL--RGAAQRSLTAHS-------S 365
RL+ W + F L N+ R L Q L HS S
Sbjct: 364 HRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGS 423
Query: 366 REKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVEC---PF 422
R V+P+ +KD+ L+ + L NG++NF+K + +SE + Q EC
Sbjct: 424 RGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSE-LRRLQNECRGYNL 482
Query: 423 ERDRKILQYLLTVPVFSEDALYLASYESEGP 453
+ D I ++L + +E + S E E P
Sbjct: 483 QPDHDIQRWLQGLRPLTEAQSHRVSCEVEPP 513
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 84.3 bits (207), Expect = 2e-16
Identities = 73/258 (28%), Positives = 116/258 (44%), Gaps = 30/258 (11%)
Query: 205 DPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNR 264
+P L++ LT++E + I ++ V SC E +E + N
Sbjct: 205 EPEELSEHLTYLEFKSFRRISFSDYQNYLVN--------SCVKENP---TMERSIALCNG 253
Query: 265 LSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTW 324
+S V + + RA + FI VA++ + NFN+LMA+I G+ S +SRLK+T
Sbjct: 254 ISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETS 313
Query: 325 AKVKTAKFDILEHQ---MDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDI 381
+ V +L + S N+ NYR A+ IP + +KD+
Sbjct: 314 SHVPHEINKVLGEMTELLSSSRNYDNYR-----------RAYGECTDFKIPILGVHLKDL 362
Query: 382 YFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---F 438
L E + L +G VN K L +SE + ++V P E + K L +LLT+ + +
Sbjct: 363 ISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEAN-KDLVHLLTLSLDLYY 421
Query: 439 SEDALYLASYESEGPENH 456
+ED +Y SY E P NH
Sbjct: 422 TEDEIYELSYARE-PRNH 438
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 84.3 bits (207), Expect = 2e-16
Identities = 73/258 (28%), Positives = 116/258 (44%), Gaps = 30/258 (11%)
Query: 205 DPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNR 264
+P L++ LT++E + I ++ V SC E +E + N
Sbjct: 205 EPEELSEHLTYLEFKSFRRISFSDYQNYLVN--------SCVKENP---TMERSIALCNG 253
Query: 265 LSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTW 324
+S V + + RA + FI VA++ + NFN+LMA+I G+ S +SRLK+T
Sbjct: 254 ISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETS 313
Query: 325 AKVKTAKFDILEHQ---MDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDI 381
+ V +L + S N+ NYR A+ IP + +KD+
Sbjct: 314 SHVPHEINKVLGEMTELLSSSRNYDNYR-----------RAYGECTDFKIPILGVHLKDL 362
Query: 382 YFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---F 438
L E + L +G VN K L +SE + ++V P E + K L +LLT+ + +
Sbjct: 363 ISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEAN-KDLVHLLTLSLDLYY 421
Query: 439 SEDALYLASYESEGPENH 456
+ED +Y SY E P NH
Sbjct: 422 TEDEIYELSYARE-PRNH 438
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 82.8 bits (203), Expect = 6e-16
Identities = 88/370 (23%), Positives = 157/370 (42%), Gaps = 43/370 (11%)
Query: 62 YIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETF 121
Y FL + R F+ P EL+ K+ + +++ S P +D + R L+ E
Sbjct: 733 YCEAFLTTYRTFISPEELIKKLQY---RYEKFS-PFADTFKKRVSKNTFFVLVRVVDELC 788
Query: 122 PYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS 181
+ +E +++ L +L R+ E + + VL K
Sbjct: 789 LVELTEE-ILKLLMELVFRLVCNGELSLAR---------------------VLRKNILDK 826
Query: 182 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN 241
D+ +L+ S V P TL +H E+L + E F + + + L
Sbjct: 827 VDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWA 886
Query: 242 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN 301
+ +K+ NL + E FN +SY V + I + K + R R++ FI + + + N
Sbjct: 887 KEQ---NEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNN 943
Query: 302 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT 361
FNS +AI+S ++ +P+ RL+ W K + +D SS+F YR AL
Sbjct: 944 FNSYLAILSALDSAPIRRLE--WQKQTSEGLAEYCTLIDSSSSFRAYRAAL--------- 992
Query: 362 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP 421
S E IP+ L+++D+ F++ G + + +G VNF K W+ + ++Q
Sbjct: 993 --SEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYD 1049
Query: 422 FERDRKILQY 431
R+ I+ +
Sbjct: 1050 MRRNDDIINF 1059
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 82.8 bits (203), Expect = 6e-16
Identities = 88/370 (23%), Positives = 157/370 (42%), Gaps = 43/370 (11%)
Query: 62 YIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETF 121
Y FL + R F+ P EL+ K+ + +++ S P +D + R L+ E
Sbjct: 715 YCEAFLTTYRTFISPEELIKKLQY---RYEKFS-PFADTFKKRVSKNTFFVLVRVVDELC 770
Query: 122 PYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTS 181
+ +E +++ L +L R+ E + + VL K
Sbjct: 771 LVELTEE-ILKLLMELVFRLVCNGELSLAR---------------------VLRKNILDK 808
Query: 182 TDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDN 241
D+ +L+ S V P TL +H E+L + E F + + + L
Sbjct: 809 VDQKKLLRCATSSQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWA 868
Query: 242 DKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGN 301
+ +K+ NL + E FN +SY V + I + K + R R++ FI + + + N
Sbjct: 869 KEQ---NEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNN 925
Query: 302 FNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLT 361
FNS +AI+S ++ +P+ RL+ W K + +D SS+F YR AL
Sbjct: 926 FNSYLAILSALDSAPIRRLE--WQKQTSEGLAEYCTLIDSSSSFRAYRAAL--------- 974
Query: 362 AHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECP 421
S E IP+ L+++D+ F++ G + + +G VNF K W+ + ++Q
Sbjct: 975 --SEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVNFSKRWQQFNILDSMRCFQQAHYD 1031
Query: 422 FERDRKILQY 431
R+ I+ +
Sbjct: 1032 MRRNDDIINF 1041
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 82.4 bits (202), Expect = 8e-16
Identities = 99/456 (21%), Positives = 183/456 (40%), Gaps = 71/456 (15%)
Query: 40 SGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSD 99
+G+LE L+++L+ D TYI FL + R F E++ L + L+ P+ +
Sbjct: 106 AGTLEKLVENLLTAFGDN-DFTYISIFLSTYRGFASTKEVLEL---LLDRYGNLTSPNCE 161
Query: 100 KNQMRK-------IAPKILQLLTEWTETFPYDFRDER---MMRNLKDLAHRIASGEEQTY 149
++ + I I +L W + DFR+ ++ L D R+ G +
Sbjct: 162 EDGSQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPER 221
Query: 150 RKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQRDIITVCNDPYTL 209
R + L Q +EV +T ++ + + C +
Sbjct: 222 RA----------QNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLV 271
Query: 210 AQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRN------LEAYVEWFN 263
A+QLT+++ + + P + +S R K N + A + FN
Sbjct: 272 AEQLTYMDAQLFKKVVPHHCLGCI------------WSRRDKKENKHLAPTIRATISQFN 319
Query: 264 RLSYLVATEIC--MPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLK 321
L+ V + I +K + RA++IE +I++A EC + NF+SL AI+S + + + RLK
Sbjct: 320 TLTKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLK 379
Query: 322 KTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIV----------- 370
KTWA V + + E D S+ N+ T+ + + ++ + V
Sbjct: 380 KTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRL 439
Query: 371 ------------IPFFSLLIKDIYFLNEGCANRLPNGHVNFEK---FWELAKQVSEFMTW 415
+P+ + D+ L+ + + G +NFEK +E+ Q+ +
Sbjct: 440 QLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSA 499
Query: 416 KQVECPFERDRKILQYLLTVPVFSEDALYLASYESE 451
C D+K +Q+ + +E+ Y S E E
Sbjct: 500 CNSYC-MTPDQKFIQWFQRQQLLTEEESYALSCEIE 534
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 80.1 bits (196), Expect = 4e-15
Identities = 62/209 (29%), Positives = 102/209 (48%), Gaps = 26/209 (12%)
Query: 205 DPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNR 264
+P +A LT E + EFV + R++T NLE ++ +
Sbjct: 218 EPEDVANHLTAFHWELFRCVHELEFVDYVFHGE---------RGRRETANLELLLQRCSE 268
Query: 265 LSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTW 324
+++ VATE+ + RA++++ FI +A C + S A++ G++ + VSRL+ TW
Sbjct: 269 VTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTW 328
Query: 325 AKVKTAKFDIL----EHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKD 380
K+ KF L E+ DP N +YR + S + VIPF L++KD
Sbjct: 329 EKL-PGKFKNLFRKFENLTDPCRNHKSYREVI-----------SKMKPPVIPFVPLILKD 376
Query: 381 IYFLNEGCANRLPNGHVNFEKFWELAKQV 409
+ FL+EG + L +G VN EK +A++V
Sbjct: 377 LTFLHEG-SKTLVDGLVNIEKLHSVAEKV 404
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 79.0 bits (193), Expect = 9e-15
Identities = 88/401 (21%), Positives = 177/401 (44%), Gaps = 52/401 (12%)
Query: 40 SGSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLC-------VEHQR 92
+G++ LI+ L ++ Y D ++ TFL + R F P EL++ + E R
Sbjct: 603 AGTVIKLIERLTYHM--YADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR 660
Query: 93 LSDPDSD-----------KNQMRKIAPKILQLLTEWTETFPYDF-RDERMMRNLKDLAHR 140
++ + D K ++ + ++L + W E YDF RD +++ +++
Sbjct: 661 IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT 720
Query: 141 IASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLTVLKTKPQSIQR-DI 199
+ + + +++ +++Q +K+A + + SS T + ++P I+ D+
Sbjct: 721 VRGKAMKKWVESITKIIQR--KKIARDNGPGHNITFQSSPPTVEWHI--SRPGHIETFDL 776
Query: 200 ITVCNDPYTLAQQLTHIELERLNYIGPEEFV-QAFVQKDPLDNDKSCYSERKKTRNLEAY 258
+T+ P +A+QLT +E + + P E V + ++D N + + T NL
Sbjct: 777 LTL--HPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTL- 833
Query: 259 VEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVS 318
WF + +V TE + R ++ I++ + + NFN ++ ++S MN SPV
Sbjct: 834 --WFEKC--IVETE-----NLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVY 884
Query: 319 RLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLI 378
RL T+ ++ + + ILE + S + Y ++ L S +PFF + +
Sbjct: 885 RLDHTFEQIPSRQKKILEEAHELSEDHY----------KKYLAKLRSINPPCVPFFGIYL 934
Query: 379 KDIYFLNEG---CANRLPNGHVNFEKFWELAKQVSEFMTWK 416
+I EG R +NF K ++A+ E ++
Sbjct: 935 TNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQ 975
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 72.8 bits (177), Expect = 6e-13
Identities = 90/394 (22%), Positives = 172/394 (43%), Gaps = 53/394 (13%)
Query: 67 LLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFR 126
LL R ++ EL K+ LC+ + N+ R KI + W FP +F
Sbjct: 39 LLMHRWYLSSTELAEKL--LCMYRNATGE---SCNEFRL---KICYFMRYWILKFPAEFN 90
Query: 127 DERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLT 186
+ + + + +AS + Y K+V + ++++ Y+ + T R
Sbjct: 91 LDLGLIRMTEEFREVAS--QLGYEKHVSLI------DISSIPSYDWM-----RRVTQRKK 137
Query: 187 VLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCY 246
V K + D + +P LA+ LT +E + I ++ Q++V L+N+ +
Sbjct: 138 VSKKGKACLLFDHL----EPIELAEHLTFLEHKSFRRISFTDY-QSYVIHGCLENNPT-- 190
Query: 247 SERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLM 306
LE + FN +S V + + RA +I FI+VA++ + NFN+LM
Sbjct: 191 --------LERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
Query: 307 AIISGMNMSPVSRLKKTWAKVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAH 363
A++ G++ S +SRLK+T + + T ++ + + + N+ NYR A
Sbjct: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAF----------- 291
Query: 364 SSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFE 423
+ + IP + +KD+ ++ + VN K +L+ +SE ++ + E
Sbjct: 292 ADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLE 351
Query: 424 RDRKILQYL-LTVPVF-SEDALYLASYESEGPEN 455
+ ++ L L++ ++ +ED +Y S E P N
Sbjct: 352 PNMDLINLLTLSLDLYHTEDDIYKLSLVLE-PRN 384
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 72.8 bits (177), Expect = 6e-13
Identities = 90/394 (22%), Positives = 172/394 (43%), Gaps = 53/394 (13%)
Query: 67 LLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFR 126
LL R ++ EL K+ LC+ + N+ R KI + W FP +F
Sbjct: 39 LLMHRWYLSSTELAEKL--LCMYRNATGE---SCNEFRL---KICYFMRYWILKFPAEFN 90
Query: 127 DERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLT 186
+ + + + +AS + Y K+V + ++++ Y+ + T R
Sbjct: 91 LDLGLIRMTEEFREVAS--QLGYEKHVSLI------DISSIPSYDWM-----RRVTQRKK 137
Query: 187 VLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCY 246
V K + D + +P LA+ LT +E + I ++ Q++V L+N+ +
Sbjct: 138 VSKKGKACLLFDHL----EPIELAEHLTFLEHKSFRRISFTDY-QSYVIHGCLENNPT-- 190
Query: 247 SERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLM 306
LE + FN +S V + + RA +I FI+VA++ + NFN+LM
Sbjct: 191 --------LERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
Query: 307 AIISGMNMSPVSRLKKTWAKVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAH 363
A++ G++ S +SRLK+T + + T ++ + + + N+ NYR A
Sbjct: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAF----------- 291
Query: 364 SSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFE 423
+ + IP + +KD+ ++ + VN K +L+ +SE ++ + E
Sbjct: 292 ADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLE 351
Query: 424 RDRKILQYL-LTVPVF-SEDALYLASYESEGPEN 455
+ ++ L L++ ++ +ED +Y S E P N
Sbjct: 352 PNMDLINLLTLSLDLYHTEDDIYKLSLVLE-PRN 384
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 72.8 bits (177), Expect = 6e-13
Identities = 90/394 (22%), Positives = 172/394 (43%), Gaps = 53/394 (13%)
Query: 67 LLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTETFPYDFR 126
LL R ++ EL K+ LC+ + N+ R KI + W FP +F
Sbjct: 39 LLMHRWYLSSTELAEKL--LCMYRNATGE---SCNEFRL---KICYFMRYWILKFPAEFN 90
Query: 127 DERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDRLT 186
+ + + + +AS + Y K+V + ++++ Y+ + T R
Sbjct: 91 LDLGLIRMTEEFREVAS--QLGYEKHVSLI------DISSIPSYDWM-----RRVTQRKK 137
Query: 187 VLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCY 246
V K + D + +P LA+ LT +E + I ++ Q++V L+N+ +
Sbjct: 138 VSKKGKACLLFDHL----EPIELAEHLTFLEHKSFRRISFTDY-QSYVIHGCLENNPT-- 190
Query: 247 SERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLM 306
LE + FN +S V + + RA +I FI+VA++ + NFN+LM
Sbjct: 191 --------LERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
Query: 307 AIISGMNMSPVSRLKKTWAKVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAH 363
A++ G++ S +SRLK+T + + T ++ + + + N+ NYR A
Sbjct: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAF----------- 291
Query: 364 SSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFE 423
+ + IP + +KD+ ++ + VN K +L+ +SE ++ + E
Sbjct: 292 ADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLE 351
Query: 424 RDRKILQYL-LTVPVF-SEDALYLASYESEGPEN 455
+ ++ L L++ ++ +ED +Y S E P N
Sbjct: 352 PNMDLINLLTLSLDLYHTEDDIYKLSLVLE-PRN 384
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 72.8 bits (177), Expect = 6e-13
Identities = 69/286 (24%), Positives = 125/286 (43%), Gaps = 36/286 (12%)
Query: 178 SSTSTDRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKD 237
S + +D+ + LK ++ D++ V + Y A Q+T +++ I P+E K
Sbjct: 24 SESLSDKGSELKKSFDAVVFDVLKVTPEEY--AGQITLMDVPVFKAIQPDELSSCGWNK- 80
Query: 238 PLDNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECF 297
K YS N A+ FN +S+ V EI K RA ++ ++I A++ +
Sbjct: 81 -----KEKYSSAP---NAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLY 132
Query: 298 NIGNFNSLMAIISGMNMSPVSRLKKTWA----KVKTAKFDILEHQMDPSSNFYNYRTALR 353
+ N ++LMA++SG+ +P+ RL KTWA K KT F+ LE+ M N+ R +
Sbjct: 133 ELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTT-FEKLEYVMSKEDNYKRLRDYI- 190
Query: 354 GAAQRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFM 413
S + IP+ + + D+ +++ A + E+ L + +
Sbjct: 191 ---------SSLKMTPCIPYLGIYLSDLTYIDS--AYPSTGSILENEQRSNLMNNILRII 239
Query: 414 TWKQVECPF--------ERDRKILQYLLTVPVFSEDALYLASYESE 451
+ Q C + ++ +QY+ + F ED Y S + E
Sbjct: 240 SDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFVEDDNYKLSLKIE 285
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 72.4 bits (176), Expect = 8e-13
Identities = 95/404 (23%), Positives = 174/404 (43%), Gaps = 60/404 (14%)
Query: 41 GSLEALIQHLVPNVDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDP---D 97
G++ LI+ L ++ Y D ++ TFL + R F P EL++ L +E + +P D
Sbjct: 602 GTVVKLIERLTYHM--YADPNFVRTFLTTYRSFCKPQELLS----LLIERFEIPEPEPTD 655
Query: 98 SDKNQMRK-------------------IAPKILQLLTEWTETFPYDFRDERMMRNLKDLA 138
+DK + K + +IL + W E YDF ER + L+ L
Sbjct: 656 ADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDF--ERDLELLERLE 713
Query: 139 HRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISSTSTDR-LTVLKTKPQSIQR 197
I+S + +K V+ + + + RK A Q V I+ S + +KP +
Sbjct: 714 SFISSVRGKAMKKWVESIAKIIRRKKQA--QANGVSHNITFESPPPPIEWHISKPGQFET 771
Query: 198 -DIITVCNDPYTLAQQLTHIELERLNYIGPEEFV-QAFVQKDPLDNDKSCYSERKKTRNL 255
D++T+ P +A+QLT +E + + P E V + ++D N + + T NL
Sbjct: 772 FDLMTL--HPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNL 829
Query: 256 EAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMS 315
WF + +V E + R ++ I++ + ++ NFN ++ I+S +N
Sbjct: 830 TL---WFEKC--IVEAE-----NFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSV 879
Query: 316 PVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFS 375
V RL T+ ++ K IL+ ++ S + + ++ L S +PFF
Sbjct: 880 SVYRLDHTFEALQERKRKILDEAVELSQDHF----------KKYLVKLKSINPPCVPFFG 929
Query: 376 LLIKDIYFLNEGCANRLP---NGHVNFEKFWELAKQVSEFMTWK 416
+ + +I EG + L +NF K ++A+ E ++
Sbjct: 930 IYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQ 973
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 71.6 bits (174), Expect = 1e-12
Identities = 66/249 (26%), Positives = 111/249 (44%), Gaps = 29/249 (11%)
Query: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
LAQ LT++E I P++ +Q + + C + LE V N +S
Sbjct: 205 LAQHLTYLEFRSFQAITPQDLRSYVLQ----GSVRGCPA-------LEGSVGLSNSVSRW 253
Query: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV- 327
V + RA++++ FI VA+ + NFN+LMA+ G+ S +SRLK + A +
Sbjct: 254 VQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLS 313
Query: 328 --KTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
T L + +N+ YR G A L P + +KD+ L+
Sbjct: 314 PDSTKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLH 362
Query: 386 EGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---FSEDA 442
E +RLP+G ++ K L ++ E + + P + +L +LLT+ + ++ED
Sbjct: 363 EAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLL-HLLTLSLDLFYTEDE 421
Query: 443 LYLASYESE 451
+Y SY E
Sbjct: 422 IYELSYARE 430
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 71.6 bits (174), Expect = 1e-12
Identities = 66/249 (26%), Positives = 111/249 (44%), Gaps = 29/249 (11%)
Query: 209 LAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSCYSERKKTRNLEAYVEWFNRLSYL 268
LAQ LT++E I P++ +Q + + C + LE V N +S
Sbjct: 191 LAQHLTYLEFRSFQAITPQDLRSYVLQ----GSVRGCPA-------LEGSVGLSNSVSRW 239
Query: 269 VATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV- 327
V + RA++++ FI VA+ + NFN+LMA+ G+ S +SRLK + A +
Sbjct: 240 VQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLS 299
Query: 328 --KTAKFDILEHQMDPSSNFYNYRTALRGAAQRSLTAHSSREKIVIPFFSLLIKDIYFLN 385
T L + +N+ YR G A L P + +KD+ L+
Sbjct: 300 PDSTKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLH 348
Query: 386 EGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPV---FSEDA 442
E +RLP+G ++ K L ++ E + + P + +L +LLT+ + ++ED
Sbjct: 349 EAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLL-HLLTLSLDLFYTEDE 407
Query: 443 LYLASYESE 451
+Y SY E
Sbjct: 408 IYELSYARE 416
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.134 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,329,573
Number of Sequences: 37866
Number of extensions: 705001
Number of successful extensions: 1658
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1542
Number of HSP's gapped (non-prelim): 79
length of query: 473
length of database: 18,247,518
effective HSP length: 106
effective length of query: 367
effective length of database: 14,233,722
effective search space: 5223775974
effective search space used: 5223775974
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.