Guide to the Human Genome
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Search of human proteins with 226371723

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226371723 FCH domain only 2 isoform a [Homo sapiens]
         (810 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226371723 FCH domain only 2 isoform a [Homo sapiens]              1600   0.0  
gi|226371725 FCH domain only 2 isoform b [Homo sapiens]              1519   0.0  
gi|239049457 FCH domain only 1 isoform b [Homo sapiens]               736   0.0  
gi|29789054 FCH domain only 1 isoform b [Homo sapiens]                736   0.0  
gi|239049440 FCH domain only 1 isoform a [Homo sapiens]               727   0.0  
gi|239049540 FCH domain only 1 isoform c [Homo sapiens]               657   0.0  
gi|116235472 SH3-domain GRB2-like (endophilin) interacting prote...   480   e-135
gi|20149528 proline-serine-threonine phosphatase interacting pro...   100   9e-21
gi|165905601 proline-serine-threonine phosphatase interacting pr...    92   3e-18
gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens]         79   1e-14
gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens]          79   1e-14
gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens]          79   1e-14
gi|41406076 growth arrest-specific 7 isoform a [Homo sapiens]          79   1e-14
gi|148747351 protein kinase C and casein kinase substrate in neu...    63   1e-09
gi|24308229 protein kinase C and casein kinase substrate in neur...    62   2e-09
gi|38524622 formin binding protein 1 [Homo sapiens]                    54   6e-07
gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]      52   2e-06
gi|19224660 protein kinase C and casein kinase substrate in neur...    51   5e-06
gi|239751395 PREDICTED: hypothetical protein, partial [Homo sapi...    50   8e-06
gi|239745904 PREDICTED: hypothetical protein, partial [Homo sapi...    50   8e-06
gi|222418647 mucin 7, secreted precursor [Homo sapiens]                49   1e-05
gi|222418649 mucin 7, secreted precursor [Homo sapiens]                49   1e-05
gi|222418645 mucin 7, secreted precursor [Homo sapiens]                49   1e-05
gi|24430146 nucleoporin 153kDa [Homo sapiens]                          49   2e-05
gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo sap...    49   2e-05
gi|55750053 atrophin-1 [Homo sapiens]                                  47   5e-05
gi|55750041 atrophin-1 [Homo sapiens]                                  47   5e-05
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     47   7e-05
gi|111120318 NK6 transcription factor related, locus 1 [Homo sap...    47   9e-05
gi|91982772 mucin 17 [Homo sapiens]                                    47   9e-05

>gi|226371723 FCH domain only 2 isoform a [Homo sapiens]
          Length = 810

 Score = 1600 bits (4143), Expect = 0.0
 Identities = 810/810 (100%), Positives = 810/810 (100%)

Query: 1   MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSA 60
           MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSA
Sbjct: 1   MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSA 60

Query: 61  SNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVA 120
           SNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVA
Sbjct: 61  SNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVA 120

Query: 121 GTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLY 180
           GTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLY
Sbjct: 121 GTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLY 180

Query: 181 VEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFIN 240
           VEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFIN
Sbjct: 181 VEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFIN 240

Query: 241 NMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK 300
           NMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK
Sbjct: 241 NMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK 300

Query: 301 DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIK 360
           DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIK
Sbjct: 301 DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIK 360

Query: 361 PMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKG 420
           PMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKG
Sbjct: 361 PMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKG 420

Query: 421 TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI 480
           TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI
Sbjct: 421 TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI 480

Query: 481 NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ 540
           NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ
Sbjct: 481 NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ 540

Query: 541 DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN 600
           DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN
Sbjct: 541 DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN 600

Query: 601 ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQ 660
           ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQ
Sbjct: 601 ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQ 660

Query: 661 VSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQ 720
           VSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQ
Sbjct: 661 VSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQ 720

Query: 721 SLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTL 780
           SLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTL
Sbjct: 721 SLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTL 780

Query: 781 SGVDFELVGTGYRLSLIKKRFATGRYLADC 810
           SGVDFELVGTGYRLSLIKKRFATGRYLADC
Sbjct: 781 SGVDFELVGTGYRLSLIKKRFATGRYLADC 810


>gi|226371725 FCH domain only 2 isoform b [Homo sapiens]
          Length = 777

 Score = 1519 bits (3934), Expect = 0.0
 Identities = 777/810 (95%), Positives = 777/810 (95%), Gaps = 33/810 (4%)

Query: 1   MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSA 60
           MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSA
Sbjct: 1   MVMAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSA 60

Query: 61  SNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVA 120
           SNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVA
Sbjct: 61  SNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVA 120

Query: 121 GTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLY 180
           GTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLY
Sbjct: 121 GTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLY 180

Query: 181 VEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFIN 240
           VEKYALAKADFEQKMTETAQ                                 VHEEFIN
Sbjct: 181 VEKYALAKADFEQKMTETAQ---------------------------------VHEEFIN 207

Query: 241 NMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK 300
           NMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK
Sbjct: 208 NMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKPRKRKTFALPGIIKKEK 267

Query: 301 DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIK 360
           DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIK
Sbjct: 268 DAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIK 327

Query: 361 PMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKG 420
           PMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKG
Sbjct: 328 PMHPNNSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKG 387

Query: 421 TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI 480
           TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI
Sbjct: 388 TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI 447

Query: 481 NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ 540
           NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ
Sbjct: 448 NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ 507

Query: 541 DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN 600
           DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN
Sbjct: 508 DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKN 567

Query: 601 ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQ 660
           ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQ
Sbjct: 568 ISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQ 627

Query: 661 VSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQ 720
           VSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQ
Sbjct: 628 VSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQ 687

Query: 721 SLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTL 780
           SLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTL
Sbjct: 688 SLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTL 747

Query: 781 SGVDFELVGTGYRLSLIKKRFATGRYLADC 810
           SGVDFELVGTGYRLSLIKKRFATGRYLADC
Sbjct: 748 SGVDFELVGTGYRLSLIKKRFATGRYLADC 777


>gi|239049457 FCH domain only 1 isoform b [Homo sapiens]
          Length = 889

 Score =  736 bits (1901), Expect = 0.0
 Identities = 404/897 (45%), Positives = 568/897 (63%), Gaps = 97/897 (10%)

Query: 3   MAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASN 62
           M+YF E+FWGEKN GF+VLYH++K G ISTKELADF+RERATIEE YS++M KL+K ASN
Sbjct: 1   MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60

Query: 63  YSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGT 122
            + +GTFAP+W+VF+ S++KLA CHL+L RKLQ+LIK+V +YGEEQ+K+HKK KEEV  T
Sbjct: 61  GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120

Query: 123 LEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVE 182
           L+AVQ +  ++Q L KS+ENY  +C++QERL++E  +Q+E++KA  K+KKA ++ +  VE
Sbjct: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180

Query: 183 KYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNM 242
           KY  A+ADFEQKM ++A +FQ +EETHL H+K ++GS ++++++ H+QIGQVHEEF  N+
Sbjct: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240

Query: 243 ANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKP-RKRKTFALPGIIKKEKD 301
            N +VE L++KFAESKGTG+E+PG ++FE    A+  E +K  R  K F LPG+ ++E++
Sbjct: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300

Query: 302 AE---SVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIE 358
            E   +V+  + DS   P+VDEEG++++P+  QN T E   +SSSDSD +DEEP+K+ + 
Sbjct: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360

Query: 359 IKPMHPN-NSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTK-SKPSAPP 416
           IKP      +    A+  +L+ + G++ L P         M R+ S +   K  +P + P
Sbjct: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGG----TMKRHSSRDAAGKPQRPRSAP 416

Query: 417 NEKGTSDLLAWDP-----LFGPSLDS---------SSSSSLTSSSS-------------- 448
                ++ L  +      LFGP L+S         SSS   TSS S              
Sbjct: 417 RTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSG 476

Query: 449 -----------------ARPTTPLSVGT----------IVPPPRPASRPKLTSG------ 475
                             RP TP S  +          I  PP P S   L S       
Sbjct: 477 LDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGL 536

Query: 476 -KLSGINEIPRPFSPPVTSNTSPPP--------AAPLARAE-------SSSSISSSASLS 519
             L+G + +P P  P      + PP        + PL R+        S S + SSA+ +
Sbjct: 537 EALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAAST 596

Query: 520 AANTPTV------GVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDM 573
           A   P+       GVSRGPSPV LG+QD LP+A A TE V+AYF+G  P+ C+ ++TG++
Sbjct: 597 ALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPS-CLARVTGEL 655

Query: 574 TMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQ 633
           TM+FP+GI++VF+  P P VL FR+ + + +E   PNA L+FSDPSQ D  TKDFW+NM 
Sbjct: 656 TMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMA 715

Query: 634 AVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYN 693
           A+T  L++ +EQNP ASYYNV +L+YQ S  G QS PL L+ +W+C A+ T + V+Y Y 
Sbjct: 716 ALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYR 775

Query: 694 PEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSL 753
           P A   P+ L+N+Q+++PV   VTN++  P A WN E+ +  W+L  +SE    GGSG L
Sbjct: 776 PGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEA---GGSGRL 832

Query: 754 RAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGRYLADC 810
            A ++   GPS P+ +A QF SEG+TLSGVD ELVG+GYR+SL+K+RFATG YL  C
Sbjct: 833 SASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889


>gi|29789054 FCH domain only 1 isoform b [Homo sapiens]
          Length = 889

 Score =  736 bits (1901), Expect = 0.0
 Identities = 404/897 (45%), Positives = 568/897 (63%), Gaps = 97/897 (10%)

Query: 3   MAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASN 62
           M+YF E+FWGEKN GF+VLYH++K G ISTKELADF+RERATIEE YS++M KL+K ASN
Sbjct: 1   MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60

Query: 63  YSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGT 122
            + +GTFAP+W+VF+ S++KLA CHL+L RKLQ+LIK+V +YGEEQ+K+HKK KEEV  T
Sbjct: 61  GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120

Query: 123 LEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVE 182
           L+AVQ +  ++Q L KS+ENY  +C++QERL++E  +Q+E++KA  K+KKA ++ +  VE
Sbjct: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180

Query: 183 KYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNM 242
           KY  A+ADFEQKM ++A +FQ +EETHL H+K ++GS ++++++ H+QIGQVHEEF  N+
Sbjct: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240

Query: 243 ANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKP-RKRKTFALPGIIKKEKD 301
            N +VE L++KFAESKGTG+E+PG ++FE    A+  E +K  R  K F LPG+ ++E++
Sbjct: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300

Query: 302 AE---SVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIE 358
            E   +V+  + DS   P+VDEEG++++P+  QN T E   +SSSDSD +DEEP+K+ + 
Sbjct: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360

Query: 359 IKPMHPN-NSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTK-SKPSAPP 416
           IKP      +    A+  +L+ + G++ L P         M R+ S +   K  +P + P
Sbjct: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGG----TMKRHSSRDAAGKPQRPRSAP 416

Query: 417 NEKGTSDLLAWDP-----LFGPSLDS---------SSSSSLTSSSS-------------- 448
                ++ L  +      LFGP L+S         SSS   TSS S              
Sbjct: 417 RTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSG 476

Query: 449 -----------------ARPTTPLSVGT----------IVPPPRPASRPKLTSG------ 475
                             RP TP S  +          I  PP P S   L S       
Sbjct: 477 LDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGL 536

Query: 476 -KLSGINEIPRPFSPPVTSNTSPPP--------AAPLARAE-------SSSSISSSASLS 519
             L+G + +P P  P      + PP        + PL R+        S S + SSA+ +
Sbjct: 537 EALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAAST 596

Query: 520 AANTPTV------GVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDM 573
           A   P+       GVSRGPSPV LG+QD LP+A A TE V+AYF+G  P+ C+ ++TG++
Sbjct: 597 ALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPS-CLARVTGEL 655

Query: 574 TMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQ 633
           TM+FP+GI++VF+  P P VL FR+ + + +E   PNA L+FSDPSQ D  TKDFW+NM 
Sbjct: 656 TMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMA 715

Query: 634 AVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYN 693
           A+T  L++ +EQNP ASYYNV +L+YQ S  G QS PL L+ +W+C A+ T + V+Y Y 
Sbjct: 716 ALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYR 775

Query: 694 PEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSL 753
           P A   P+ L+N+Q+++PV   VTN++  P A WN E+ +  W+L  +SE    GGSG L
Sbjct: 776 PGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEA---GGSGRL 832

Query: 754 RAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGRYLADC 810
            A ++   GPS P+ +A QF SEG+TLSGVD ELVG+GYR+SL+K+RFATG YL  C
Sbjct: 833 SASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFATGMYLVSC 889


>gi|239049440 FCH domain only 1 isoform a [Homo sapiens]
          Length = 891

 Score =  727 bits (1876), Expect = 0.0
 Identities = 400/890 (44%), Positives = 564/890 (63%), Gaps = 97/890 (10%)

Query: 3   MAYFVENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASN 62
           M+YF E+FWGEKN GF+VLYH++K G ISTKELADF+RERATIEE YS++M KL+K ASN
Sbjct: 1   MSYFGEHFWGEKNHGFEVLYHSVKQGPISTKELADFIRERATIEETYSKAMAKLSKLASN 60

Query: 63  YSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGT 122
            + +GTFAP+W+VF+ S++KLA CHL+L RKLQ+LIK+V +YGEEQ+K+HKK KEEV  T
Sbjct: 61  GTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTHKKCKEEVVST 120

Query: 123 LEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVE 182
           L+AVQ +  ++Q L KS+ENY  +C++QERL++E  +Q+E++KA  K+KKA ++ +  VE
Sbjct: 121 LDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKKAAESLRRSVE 180

Query: 183 KYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQVHEEFINNM 242
           KY  A+ADFEQKM ++A +FQ +EETHL H+K ++GS ++++++ H+QIGQVHEEF  N+
Sbjct: 181 KYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIGQVHEEFKQNI 240

Query: 243 ANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKP-RKRKTFALPGIIKKEKD 301
            N +VE L++KFAESKGTG+E+PG ++FE    A+  E +K  R  K F LPG+ ++E++
Sbjct: 241 ENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFRLPGLSRRERE 300

Query: 302 AE---SVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKYRIE 358
            E   +V+  + DS   P+VDEEG++++P+  QN T E   +SSSDSD +DEEP+K+ + 
Sbjct: 301 PEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFDDEEPRKFYVH 360

Query: 359 IKPMHPN-NSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTK-SKPSAPP 416
           IKP      +    A+  +L+ + G++ L P         M R+ S +   K  +P + P
Sbjct: 361 IKPAPARAPACSPEAAAAQLRATAGSLILPPGPGG----TMKRHSSRDAAGKPQRPRSAP 416

Query: 417 NEKGTSDLLAWDP-----LFGPSLDS---------SSSSSLTSSSS-------------- 448
                ++ L  +      LFGP L+S         SSS   TSS S              
Sbjct: 417 RTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSSSSPENVEDSG 476

Query: 449 -----------------ARPTTPLSVGT----------IVPPPRPASRPKLTSG------ 475
                             RP TP S  +          I  PP P S   L S       
Sbjct: 477 LDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQPLASSPGPWGL 536

Query: 476 -KLSGINEIPRPFSPPVTSNTSPPP--------AAPLARAE-------SSSSISSSASLS 519
             L+G + +P P  P      + PP        + PL R+        S S + SSA+ +
Sbjct: 537 EALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSPSPLGSSAAST 596

Query: 520 AANTPTV------GVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDM 573
           A   P+       GVSRGPSPV LG+QD LP+A A TE V+AYF+G  P+ C+ ++TG++
Sbjct: 597 ALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPS-CLARVTGEL 655

Query: 574 TMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQ 633
           TM+FP+GI++VF+  P P VL FR+ + + +E   PNA L+FSDPSQ D  TKDFW+NM 
Sbjct: 656 TMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDPETKDFWLNMA 715

Query: 634 AVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYN 693
           A+T  L++ +EQNP ASYYNV +L+YQ S  G QS PL L+ +W+C A+ T + V+Y Y 
Sbjct: 716 ALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATLTQVSVEYGYR 775

Query: 694 PEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSL 753
           P A   P+ L+N+Q+++PV   VTN++  P A WN E+ +  W+L  +SE    GGSG L
Sbjct: 776 PGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSEA---GGSGRL 832

Query: 754 RAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFAT 803
            A ++   GPS P+ +A QF SEG+TLSGVD ELVG+GYR+SL+K+RFAT
Sbjct: 833 SASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFAT 882


>gi|239049540 FCH domain only 1 isoform c [Homo sapiens]
          Length = 839

 Score =  657 bits (1694), Expect = 0.0
 Identities = 367/847 (43%), Positives = 523/847 (61%), Gaps = 97/847 (11%)

Query: 53  MTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSH 112
           M KL+K ASN + +GTFAP+W+VF+ S++KLA CHL+L RKLQ+LIK+V +YGEEQ+K+H
Sbjct: 1   MAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLQDLIKDVLRYGEEQLKTH 60

Query: 113 KKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKK 172
           KK KEEV  TL+AVQ +  ++Q L KS+ENY  +C++QERL++E  +Q+E++KA  K+KK
Sbjct: 61  KKCKEEVVSTLDAVQVLSGVSQLLPKSRENYLNRCMDQERLRRESTSQKEMDKAETKTKK 120

Query: 173 ATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQIG 232
           A ++ +  VEKY  A+ADFEQKM ++A +FQ +EETHL H+K ++GS ++++++ H+QIG
Sbjct: 121 AAESLRRSVEKYNSARADFEQKMLDSALRFQAMEETHLRHMKALLGSYAHSVEDTHVQIG 180

Query: 233 QVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEECDTASAVEGIKP-RKRKTFA 291
           QVHEEF  N+ N +VE L++KFAESKGTG+E+PG ++FE    A+  E +K  R  K F 
Sbjct: 181 QVHEEFKQNIENVSVEMLLRKFAESKGTGREKPGPLDFEAYSAAALQEAMKRLRGAKAFR 240

Query: 292 LPGIIKKEKDAE---SVECPDADSLNIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSE 348
           LPG+ ++E++ E   +V+  + DS   P+VDEEG++++P+  QN T E   +SSSDSD +
Sbjct: 241 LPGLSRREREPEPPAAVDFLEPDSGTCPEVDEEGFTVRPDVTQNSTAEPSRFSSSDSDFD 300

Query: 349 DEEPKKYRIEIKPMHPN-NSHHTMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEEL 407
           DEEP+K+ + IKP      +    A+  +L+ + G++ L P         M R+ S +  
Sbjct: 301 DEEPRKFYVHIKPAPARAPACSPEAAAAQLRATAGSLILPPGPGG----TMKRHSSRDAA 356

Query: 408 TK-SKPSAPPNEKGTSDLLAWDP-----LFGPSLDS---------SSSSSLTSSSS---- 448
            K  +P + P     ++ L  +      LFGP L+S         SSS   TSS S    
Sbjct: 357 GKPQRPRSAPRTSSCAERLQSEEQVSKNLFGPPLESAFDHEDFTGSSSLGFTSSPSPFSS 416

Query: 449 ---------------------------ARPTTPLSVGT----------IVPPPRPASRPK 471
                                       RP TP S  +          I  PP P S   
Sbjct: 417 SSPENVEDSGLDSPSHAAPGPSPDSWVPRPGTPQSPPSCRAPPPEARGIRAPPLPDSPQP 476

Query: 472 LTSG-------KLSGINEIPRPFSPPVTSNTSPPP--------AAPLARAE-------SS 509
           L S         L+G + +P P  P      + PP        + PL R+        S 
Sbjct: 477 LASSPGPWGLEALAGGDLMPAPADPTAREGLAAPPRRLRSRKVSCPLTRSNGDLSRSLSP 536

Query: 510 SSISSSASLSAANTPTV------GVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPT 563
           S + SSA+ +A   P+       GVSRGPSPV LG+QD LP+A A TE V+AYF+G  P+
Sbjct: 537 SPLGSSAASTALERPSFLSQTGHGVSRGPSPVVLGSQDALPIATAFTEYVHAYFRGHSPS 596

Query: 564 KCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDS 623
            C+ ++TG++TM+FP+GI++VF+  P P VL FR+ + + +E   PNA L+FSDPSQ D 
Sbjct: 597 -CLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVHTTAIEHFQPNADLLFSDPSQSDP 655

Query: 624 NTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSAST 683
            TKDFW+NM A+T  L++ +EQNP ASYYNV +L+YQ S  G QS PL L+ +W+C A+ 
Sbjct: 656 ETKDFWLNMAALTEALQRQAEQNPTASYYNVVLLRYQFSRPGPQSVPLQLSAHWQCGATL 715

Query: 684 TDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISE 743
           T + V+Y Y P A   P+ L+N+Q+++PV   VTN++  P A WN E+ +  W+L  +SE
Sbjct: 716 TQVSVEYGYRPGATAVPTPLTNVQILLPVGEPVTNVRLQPAATWNLEEKRLTWRLPDVSE 775

Query: 744 KSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFAT 803
               GGSG L A ++   GPS P+ +A QF SEG+TLSGVD ELVG+GYR+SL+K+RFAT
Sbjct: 776 A---GGSGRLSASWEPLSGPSTPSPVAAQFTSEGTTLSGVDLELVGSGYRMSLVKRRFAT 832

Query: 804 GRYLADC 810
           G YL  C
Sbjct: 833 GMYLVSC 839


>gi|116235472 SH3-domain GRB2-like (endophilin) interacting protein
           1 [Homo sapiens]
          Length = 828

 Score =  480 bits (1235), Expect = e-135
 Identities = 251/424 (59%), Positives = 304/424 (71%), Gaps = 29/424 (6%)

Query: 411 KPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPL----SVGTIVPPPRP 466
           + + PP    T   +   P  GP       ++  +SS ARP TPL    S     PPPRP
Sbjct: 408 RATPPPPPPPTYRTVVSSP--GPGSGPGPGTTSGASSPARPATPLVPCRSTTPPPPPPRP 465

Query: 467 ASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTV 526
            SRPKL  GK  G+ ++ RPFSPP+ S+ SPPP APLARAES+SSISS+ SLSAA TPTV
Sbjct: 466 PSRPKLPPGK-PGVGDVSRPFSPPIHSS-SPPPIAPLARAESTSSISSTNSLSAATTPTV 523

Query: 527 --------------------GVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCI 566
                               G SRGPSP+++G QDTLPVA A TE+VNAYFKGADP+KCI
Sbjct: 524 ENEQPSLVWFDRGKFYLTFEGSSRGPSPLTMGAQDTLPVAAAFTETVNAYFKGADPSKCI 583

Query: 567 VKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTK 626
           VKITG+M +SFP+GI + F +NP+PA L FRV N SRLE +LPN QL+  D +Q D+NTK
Sbjct: 584 VKITGEMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTK 643

Query: 627 DFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDL 686
           +FW+NM  +  +LKK+SEQ P A+YYNVD+LKYQVS+ GIQSTPLNLA  W+C  S+TDL
Sbjct: 644 EFWVNMPNLMTHLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDL 703

Query: 687 RVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQS-LPPAIWNAEQMKAFWKLSSISEKS 745
           R+DYKYN +AM     L+N+Q +VP+DGGVT +Q+ LPPA+WNAEQ +  WK+  IS+KS
Sbjct: 704 RIDYKYNTDAMTTAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKS 763

Query: 746 ENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGSTLSGVDFELVGTGYRLSLIKKRFATGR 805
           ENGG GSL A+F LSEGPSKP+ L VQF SEGSTLSG D ELVG GYR SLIKKRFA G+
Sbjct: 764 ENGGVGSLLARFQLSEGPSKPSPLVVQFTSEGSTLSGCDIELVGAGYRFSLIKKRFAAGK 823

Query: 806 YLAD 809
           YLAD
Sbjct: 824 YLAD 827



 Score =  128 bits (321), Expect = 2e-29
 Identities = 113/360 (31%), Positives = 150/360 (41%), Gaps = 108/360 (30%)

Query: 279 VEGIKPRKRKTFALPGIIKKEKDAESVECPDADSL------------------------- 313
           +EG+K R RK F   GI KKEKD +S   PD D +                         
Sbjct: 2   MEGLKKRTRKAF---GIRKKEKDTDSTGSPDRDGIQPSPHEPPYNSKAECAREGGKKVSK 58

Query: 314 ------------------NIPDVDEEGYSIKPETNQNDTKENHFYSSSDSDSEDEEPKKY 355
                             N P++DEEGYSI+PE     TK  HFYSSS+S+ E+E  KK+
Sbjct: 59  KSNGAPNGFYAEIDWERYNSPELDEEGYSIRPE-EPGSTKGKHFYSSSESEEEEESHKKF 117

Query: 356 RIEIKPMHPNNSHHTMASLDELKVSIGNITLSPA----ISRHSPVQMNRNLSNEELTKSK 411
            I+IKP+   +     A++DELK SIGNI LSP+      R SP  + RNLS+EE+ + +
Sbjct: 118 NIKIKPLQSKDILKNAATVDELKASIGNIALSPSPVRKSPRRSPGAIKRNLSSEEVARPR 177

Query: 412 PSAPPNE----KGTSDLLAWDPLFGPSLDSSSSSSLT------------------SSSSA 449
            S P  E    K   D  A  PLFGP L+S+     T                  S  S 
Sbjct: 178 RSTPTPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESP 237

Query: 450 RPTTPLSVGTIVP-PPR--PASRPK----LTSG-------------KLSGINEIPRPFSP 489
           + T P   GT  P PP+  PA+ P+    LT G             KL  IN++   F P
Sbjct: 238 KLTRPFPTGTPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFGP 297

Query: 490 PVT---------------SNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSP 534
            ++               S+TSP    P            +   + A++P  G    P P
Sbjct: 298 VLSPKSVAVNAEEKWVHFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPGP 357


>gi|20149528 proline-serine-threonine phosphatase interacting
           protein 1 [Homo sapiens]
          Length = 416

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 88/407 (21%), Positives = 181/407 (44%), Gaps = 46/407 (11%)

Query: 1   MVMAYFVENFWGEK---NSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLA 57
           M    F + FW      ++G++VL   +  G+   K++ + +R+RA  EE Y + + ++A
Sbjct: 2   MPQLQFKDAFWCRDFTAHTGYEVLLQRLLDGRKMCKDMEELLRQRAQAEERYGKELVQIA 61

Query: 58  KSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKE 117
           + A   +++ +    +D  K   E + + H+ L   L+E ++ ++++ E Q +  KK + 
Sbjct: 62  RKAGGQTEINSLRASFDSLKQQMENVGSSHIQLALTLREELRSLEEFRERQKEQRKKYE- 120

Query: 118 EVAGTLEAVQTIQ-SITQALQKSKENYNAKC-----VEQ--ERLKKEGATQREIEKAAVK 169
                ++ VQ  + S+ +   +SK+ Y  KC      EQ  ER+   G  Q+++EK+  K
Sbjct: 121 ---AVMDRVQKSKLSLYKKAMESKKTYEQKCRDADDAEQAFERISANG-HQKQVEKSQNK 176

Query: 170 SKKATDT-------YKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSN 222
           +++  D+       Y+  + +    +A++EQ+   T + FQ  E   L  ++  +   SN
Sbjct: 177 ARQCKDSATEAERVYRQSIAQLEKVRAEWEQEHRTTCEAFQLQEFDRLTILRNALWVHSN 236

Query: 223 AIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFE-----ECDTAS 277
            +    ++  +++EE    +   ++++ I  F ++K TG E P  + ++     E    +
Sbjct: 237 QLSMQCVKDDELYEEVRLTLEGCSIDADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLT 296

Query: 278 AVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKEN 337
           +  GI+P         G++           P   SL       E  +  PE N+      
Sbjct: 297 SSPGIQPSCGMIKRFSGLLHGS--------PKTTSLAASAASTETLTPTPERNEG----- 343

Query: 338 HFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNI 384
             Y++         P     E + ++     +T  + DEL +S G+I
Sbjct: 344 -VYTAIAVQEIQGNPASPAQEYRALY----DYTAQNPDELDLSAGDI 385


>gi|165905601 proline-serine-threonine phosphatase interacting
           protein 2 [Homo sapiens]
          Length = 334

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 64/288 (22%), Positives = 138/288 (47%), Gaps = 20/288 (6%)

Query: 1   MVMAYFVENFWGE---KNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLA 57
           M  + F  NFW        G+D +  ++ +G+ + KE  DF++ERA IEE Y + +  L+
Sbjct: 1   MTRSLFKGNFWSADILSTIGYDNIIQHLNNGRKNCKEFEDFLKERAAIEERYGKDLLNLS 60

Query: 58  -KSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTK 116
            K     S++ T     +VFK   + +A CH+ L + L+E  ++++++ E+Q    KKT 
Sbjct: 61  RKKPCGQSEINTLKRALEVFKQQVDNVAQCHIQLAQSLREEARKMEEFREKQKLQRKKT- 119

Query: 117 EEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGA------TQREIEKAAVK- 169
           E +   +   +++Q   +    +K+NY  KC +++  ++  +        ++ EK  VK 
Sbjct: 120 ELIMDAIHKQKSLQ--FKKTMDAKKNYEQKCRDKDEAEQAVSRSANLVNPKQQEKLFVKL 177

Query: 170 --SKKATD----TYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNA 223
             SK A +     Y L++      + +++ +  +  + F+  E   +   +  +    N 
Sbjct: 178 ATSKTAVEDSDKAYMLHIGTLDKVREEWQSEHIKACEAFEAQECERINFFRNALWLHVNQ 237

Query: 224 IKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFE 271
           + +  +   +++E+   ++   +++  I+ F   + TG+  P  I +E
Sbjct: 238 LSQQCVTSDEMYEQVRKSLEMCSIQRDIEYFVNQRKTGQIPPAPIMYE 285


>gi|195546919 growth arrest-specific 7 isoform d [Homo sapiens]
          Length = 412

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 55/223 (24%), Positives = 107/223 (47%), Gaps = 14/223 (6%)

Query: 6   FVENFWGEKN--------SGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLA 57
           + + FW +K         +GF++L      G+   KE+++F+RER  IEE Y++++ KL+
Sbjct: 136 YCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLS 195

Query: 58  KSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKL-QELIKEVQKYGEEQVKSHKKTK 116
           +++    + G+    W   K S    A  HL    KL  E+ K +  + E   K  KK  
Sbjct: 196 QNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCD 255

Query: 117 EEVAGTLEAV----QTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKK 172
             +A   + +     +++   +AL + + +   K  +Q  +K    T+ +I+KA  KS +
Sbjct: 256 HHIADLRKQLASRYASVEKARKALTERQRDLEMK-TQQLEIKLSNKTEEDIKKARRKSTQ 314

Query: 173 ATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKE 215
           A D     V+ Y  A++ + ++M  T  + + +E   +  I++
Sbjct: 315 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQ 357


>gi|41406080 growth arrest-specific 7 isoform c [Homo sapiens]
          Length = 476

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 55/223 (24%), Positives = 107/223 (47%), Gaps = 14/223 (6%)

Query: 6   FVENFWGEKN--------SGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLA 57
           + + FW +K         +GF++L      G+   KE+++F+RER  IEE Y++++ KL+
Sbjct: 200 YCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLS 259

Query: 58  KSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKL-QELIKEVQKYGEEQVKSHKKTK 116
           +++    + G+    W   K S    A  HL    KL  E+ K +  + E   K  KK  
Sbjct: 260 QNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCD 319

Query: 117 EEVAGTLEAV----QTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKK 172
             +A   + +     +++   +AL + + +   K  +Q  +K    T+ +I+KA  KS +
Sbjct: 320 HHIADLRKQLASRYASVEKARKALTERQRDLEMK-TQQLEIKLSNKTEEDIKKARRKSTQ 378

Query: 173 ATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKE 215
           A D     V+ Y  A++ + ++M  T  + + +E   +  I++
Sbjct: 379 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQ 421


>gi|41406078 growth arrest-specific 7 isoform b [Homo sapiens]
          Length = 416

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 55/223 (24%), Positives = 107/223 (47%), Gaps = 14/223 (6%)

Query: 6   FVENFWGEKN--------SGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLA 57
           + + FW +K         +GF++L      G+   KE+++F+RER  IEE Y++++ KL+
Sbjct: 140 YCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLS 199

Query: 58  KSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKL-QELIKEVQKYGEEQVKSHKKTK 116
           +++    + G+    W   K S    A  HL    KL  E+ K +  + E   K  KK  
Sbjct: 200 QNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCD 259

Query: 117 EEVAGTLEAV----QTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKK 172
             +A   + +     +++   +AL + + +   K  +Q  +K    T+ +I+KA  KS +
Sbjct: 260 HHIADLRKQLASRYASVEKARKALTERQRDLEMK-TQQLEIKLSNKTEEDIKKARRKSTQ 318

Query: 173 ATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKE 215
           A D     V+ Y  A++ + ++M  T  + + +E   +  I++
Sbjct: 319 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQ 361


>gi|41406076 growth arrest-specific 7 isoform a [Homo sapiens]
          Length = 336

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 55/223 (24%), Positives = 107/223 (47%), Gaps = 14/223 (6%)

Query: 6   FVENFWGEKN--------SGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLA 57
           + + FW +K         +GF++L      G+   KE+++F+RER  IEE Y++++ KL+
Sbjct: 60  YCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLS 119

Query: 58  KSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKL-QELIKEVQKYGEEQVKSHKKTK 116
           +++    + G+    W   K S    A  HL    KL  E+ K +  + E   K  KK  
Sbjct: 120 QNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCD 179

Query: 117 EEVAGTLEAV----QTIQSITQALQKSKENYNAKCVEQERLKKEGATQREIEKAAVKSKK 172
             +A   + +     +++   +AL + + +   K  +Q  +K    T+ +I+KA  KS +
Sbjct: 180 HHIADLRKQLASRYASVEKARKALTERQRDLEMK-TQQLEIKLSNKTEEDIKKARRKSTQ 238

Query: 173 ATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKE 215
           A D     V+ Y  A++ + ++M  T  + + +E   +  I++
Sbjct: 239 AGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQ 281


>gi|148747351 protein kinase C and casein kinase substrate in
           neurons 2 [Homo sapiens]
          Length = 486

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 82/384 (21%), Positives = 159/384 (41%), Gaps = 54/384 (14%)

Query: 8   ENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKS----ASNY 63
           ++FW   N  +      +  G     +L + + ERA IE+AY++ +T+ A+         
Sbjct: 16  DSFWEVGN--YKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKG 73

Query: 64  SQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQ----ELIKEVQK--YGEEQVKSHKKTKE 117
            Q GT    W  F +  E+++  HL++   L     E IK  QK  + ++ +   K+TKE
Sbjct: 74  PQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMMGGFKETKE 133

Query: 118 EVAGTLEAVQTIQSITQALQKSKENYNAKCVEQ------------------ERLKKEGAT 159
              G  +A +      + ++ +K+ ++A C E+                  E+LKK    
Sbjct: 134 AEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPEQLKK---L 190

Query: 160 QREIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGS 219
           Q +IEK      K  + Y+  +++       + + M +  ++ Q  EE  L   +E++  
Sbjct: 191 QDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLE 250

Query: 220 LSNAIKEIHLQIGQV-------HEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEE 272
           +       HL +  V       H+   +  A   VE L + F  + G G       +FEE
Sbjct: 251 VQK-----HLDLSNVAGYKAIYHDLEQSIRAADAVEDL-RWFRANHGPGMAM-NWPQFEE 303

Query: 273 CDTASAVEGIKPRKRKTFALPGIIK---KEKDAESVECPDADSLNIPDVDEEGYSIKPET 329
              ++ +     R+ K  A  G+      +   +S+    + +LN+P       S + ++
Sbjct: 304 --WSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVP--SNPAQSAQSQS 359

Query: 330 NQNDTKENHFYSSSDSDSEDEEPK 353
           + N  ++     S+ S+ +D + K
Sbjct: 360 SYNPFEDEDDTGSTVSEKDDTKAK 383


>gi|24308229 protein kinase C and casein kinase substrate in neurons
           1 [Homo sapiens]
          Length = 444

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 58/285 (20%), Positives = 116/285 (40%), Gaps = 38/285 (13%)

Query: 8   ENFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKS----ASNY 63
           ++FW   N  +      +  G     +L + V+ERA IE+AY + +T  AK         
Sbjct: 17  DSFWEVGN--YKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLIEKG 74

Query: 64  SQLGTFAPVWDVFKTSTEKLANCHLDLVRKL----QELIKEVQK--YGEEQVKSHKKTKE 117
            Q G+    W    T  +K++  H ++   L     E +K  QK  Y ++ +   K+TKE
Sbjct: 75  PQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKE 134

Query: 118 EVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERL---------------KKEGATQRE 162
              G  +A +      + L+ +K+ Y+  C E++                 +++   Q +
Sbjct: 135 AEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDK 194

Query: 163 IEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSN 222
           ++K     +K  + Y+  +E        + + M +  ++ Q  EE  L+ +KE++  +  
Sbjct: 195 VDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKR 254

Query: 223 AIKEIHLQIGQ------VHEEFINNMANTTVESLIQKFAESKGTG 261
                HL + +      V+ E    +     +  ++ F  + G G
Sbjct: 255 -----HLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPG 294


>gi|38524622 formin binding protein 1 [Homo sapiens]
          Length = 617

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 64/300 (21%), Positives = 126/300 (42%), Gaps = 54/300 (18%)

Query: 11  WG-EKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKS---------- 59
           WG E    FD L  + + G    ++   FV+ER  IE +Y++ +  L+K           
Sbjct: 3   WGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEE 62

Query: 60  -----------ASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQ 108
                       SN +++  +A   +V   S    +   +DL R +QEL +E        
Sbjct: 63  EEYKYTSCKAFISNLNEMNDYAGQHEVI--SENMASQIIVDLARYVQELKQE-------- 112

Query: 109 VKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKE--------GATQ 160
                  K       +A Q I++  + L+ SK  +   C E +R ++           T+
Sbjct: 113 ------RKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTK 166

Query: 161 REIEKAA----VKSKKATDT---YKLYVEKYALAKADF-EQKMTETAQKFQDIEETHLIH 212
            ++EKA     ++ + A D+   Y   ++K+   + ++    +    QK Q++EE  ++ 
Sbjct: 167 ADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQEMEERRIVR 226

Query: 213 IKEIIGSLSNAIKEIHLQIGQVHEEFINNMANTTVESLIQKFAESKGTGKERPGLIEFEE 272
           + E + + +   +++   IG+  +  +    +   ++  Q   E+  +G E PG IEFE+
Sbjct: 227 MGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGFEPPGDIEFED 286


>gi|11342676 thyroid hormone receptor interactor 10 [Homo sapiens]
          Length = 545

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 65/292 (22%), Positives = 120/292 (41%), Gaps = 38/292 (13%)

Query: 11  WG-EKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKS---------- 59
           WG E    F+VL  + + G         FV+ER  +E+AY++ +  L K           
Sbjct: 3   WGTELWDQFEVLERHTQWGLDLLDRYVKFVKERTEVEQAYAKQLRSLVKKYLPKRPAKDD 62

Query: 60  -ASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEE 118
             S +SQ  +F     + +   +      L        +  E+ KY +E  +  K   +E
Sbjct: 63  PESKFSQQQSFV---QILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQE 119

Query: 119 VAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKE--------GATQREIEKAAVK- 169
                 A Q +++  + L+ SK  +   C E E+  +          AT+ ++EKA  + 
Sbjct: 120 ---GRRAQQQLENGFKQLENSKRKFERDCREAEKAAQTAERLDQDINATKADVEKAKQQA 176

Query: 170 ------SKKATDTYKLYVEKYALAKADFE-QKMTETAQKFQDIEETHLIHIKEIIGSLSN 222
                 ++++ + Y   ++++   +A F   +M +   K QD++E     +    G LS 
Sbjct: 177 HLRSHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSE 236

Query: 223 AIKEIHLQIGQVHE--EFINNMANTTVESLIQKFAESKGTGKERPGLIEFEE 272
           A  E+   I +  E  +   N  +   +S +    E   +G  RPG +EFE+
Sbjct: 237 AELEVVPIIAKCLEGMKVAANAVDPKNDSHV--LIELHKSGFARPGDVEFED 286


>gi|19224660 protein kinase C and casein kinase substrate in neurons
           3 [Homo sapiens]
          Length = 424

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 55/261 (21%), Positives = 109/261 (41%), Gaps = 41/261 (15%)

Query: 9   NFWGEKNSGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAK----SASNYS 64
           +FW   N    V    ++ G     +L    +ERA IE+AY++ +   A+    +     
Sbjct: 15  SFWEAGNYRRTV--QRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGTVEKGP 72

Query: 65  QLGTFAPVWDVFKTSTEKLANCHLDLVRKLQ----ELIKEVQK--YGEEQVKSHKKTKEE 118
           Q GT    W  F T+ E+L+  HL++  KLQ    E ++  Q+  +    +   ++++  
Sbjct: 73  QYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHRPVLGGFRESRAA 132

Query: 119 VAGTLEAVQTIQSITQALQKSKENYNA------------------KCVEQERLKKEGATQ 160
             G  +A +      + ++ SK++Y+A                    V QE+L+K    Q
Sbjct: 133 EDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAVSQEQLRK---LQ 189

Query: 161 REIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIHIKEIIGSL 220
             +E+ A +++K    Y+  + +       + + M +  +  Q  E   L+  K+++ +L
Sbjct: 190 ERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLLFFKDMLLTL 249

Query: 221 --------SNAIKEIHLQIGQ 233
                   S    E+H  + Q
Sbjct: 250 HQHLDLSSSEKFHELHRDLHQ 270


>gi|239751395 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 306

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 9/112 (8%)

Query: 429 PLFGPSLDSSSSSSLTSSSSARPT-TPLSVGTIVPPPRP----ASRPKLTSGKLSGINEI 483
           P   P L  SS+ +LT SS+  PT TP S  T+ P   P    +SRP LT      +   
Sbjct: 162 PSSRPILTRSSTPTLTPSST--PTLTPSSTPTLTPSSTPTLTPSSRPILTRSSTPTLTPS 219

Query: 484 PRPFSPPVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
            RP   P ++ T  P + P+    S+ ++  SS+ +L+ +NTPT+  S  P+
Sbjct: 220 SRPILTPSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSNTPTLTPSNTPT 271



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 17/116 (14%)

Query: 433 PSLDSSSSSSLTSSSSARPT-TPLSVGTIVPPPRP------------ASRPKLTSGKLSG 479
           P+L  SS+ +LT SS+  PT TP S  T+ P  RP            +SRP LT      
Sbjct: 174 PTLTPSSTPTLTPSST--PTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTPSSTPT 231

Query: 480 INEIPRPFSPPVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
           +    RP     ++ T  P + P     ++ ++  S++ +L+ +NTPT+  S  P+
Sbjct: 232 LTPSSRPILTRSSTPTLTPSSTPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSSTPT 287



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 5/110 (4%)

Query: 429 PLFGPSLDSSSSSSLTSSSS---ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPR 485
           P   P L  SS+ +LT SS     R +TP    +  P   P+S P LT      +    R
Sbjct: 146 PSSRPILTRSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSSTPTLTPSSTPTLTPSSR 205

Query: 486 PFSPPVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
           P     ++ T  P + P+    S+ ++  SS   L+ ++TPT+  S  P+
Sbjct: 206 PILTRSSTPTLTPSSRPILTPSSTPTLTPSSRPILTRSSTPTLTPSSTPT 255



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 14/122 (11%)

Query: 412 PSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPT-TPLSVGTIVPPPRPASRP 470
           PS+PP     S+     P   P+L  S++ +LT SS+  PT TP S  T+ P    +SRP
Sbjct: 98  PSSPPTLT-PSNTPTLTPSNTPTLTPSNTPTLTPSST--PTLTPSSTPTLTP----SSRP 150

Query: 471 KLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSR 530
            LT      +     P S P+ + +S P   P   +  + + SS+ +L+ ++TPT+  S 
Sbjct: 151 ILTRSSTPTLT----PSSRPILTRSSTPTLTP--SSTPTLTPSSTPTLTPSSTPTLTPSS 204

Query: 531 GP 532
            P
Sbjct: 205 RP 206



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 5/106 (4%)

Query: 433 PSLDSSSSSSLTSSSSARPT---TPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSP 489
           P+L  SS  +LT S++   T   TP    +  P   P+S P LT      +    RP   
Sbjct: 94  PTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPTLTPSSRPILT 153

Query: 490 PVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
             ++ T  P + P+    S+ ++  SS+ +L+ ++TPT+  S  P+
Sbjct: 154 RSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSSTPTLTPSSTPT 199



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 3/108 (2%)

Query: 429 PLFGPSLDSSSSSSLTSSSS---ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPR 485
           P   P+L  SS+ +LT SS     R +TP    +  P   P++ P LT      +     
Sbjct: 12  PSSPPTLTPSSTPTLTPSSQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSST 71

Query: 486 PFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPS 533
           P   P ++ T  P       +  + + SS  +L+ +NTPT+  S  P+
Sbjct: 72  PTLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPT 119



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 44/161 (27%), Positives = 73/161 (45%), Gaps = 14/161 (8%)

Query: 388 PAISRHSPVQMNRNLSNEELTKSK-PSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSS 446
           P ++R S   +  + S   LT+S  P+  P+   T       P   P+L  SS+ +LT S
Sbjct: 150 PILTRSSTPTLTPS-SRPILTRSSTPTLTPSSTPTLT-----PSSTPTLTPSSTPTLTPS 203

Query: 447 SS---ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPL 503
           S     R +TP    +  P   P+S P LT      +     P   P ++ T  P   P 
Sbjct: 204 SRPILTRSSTPTLTPSSRPILTPSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSNTPT 263

Query: 504 ARAESSSSI--SSSASLSAANTPTVGVSRGP--SPVSLGNQ 540
               ++ ++  S++ +L+ ++TPT+  S  P  +P SL +Q
Sbjct: 264 LTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPTLTPSSLWHQ 304



 Score = 37.0 bits (84), Expect = 0.073
 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 429 PLFGPSLDSSSSSSLTSSSSARPT---TPLSVGTIVPPPRPASRPKLTSGKLSGINEIPR 485
           P   P+L  S++ +LT S++   T   TP    +  P   P+S P LT            
Sbjct: 98  PSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPTLT------------ 145

Query: 486 PFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPS 533
           P S P+ + +S P   P +R   +   SS+ +L+ ++TPT+  S  P+
Sbjct: 146 PSSRPILTRSSTPTLTPSSRPILTR--SSTPTLTPSSTPTLTPSSTPT 191



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 37/144 (25%), Positives = 60/144 (41%), Gaps = 19/144 (13%)

Query: 453 TPLSVGTIVP--PPR--PASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAES 508
           TP +  T+ P  PP   P+S P LT            P S P+ + +S P   P   +  
Sbjct: 3   TPSNTPTLTPSSPPTLTPSSTPTLT------------PSSQPILTRSSTPTLTP--SSPP 48

Query: 509 SSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVK 568
           + + S++ +L+ +NTPT+  S  P+ ++  +  TL     LT S       + P      
Sbjct: 49  TLTPSNTPTLTPSNTPTLTPSSTPT-LTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPS 107

Query: 569 ITGDMTMSFPSGIIKVFTSNPTPA 592
            T  +T S    +    T   TP+
Sbjct: 108 NTPTLTPSNTPTLTPSNTPTLTPS 131


>gi|239745904 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 306

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 9/112 (8%)

Query: 429 PLFGPSLDSSSSSSLTSSSSARPT-TPLSVGTIVPPPRP----ASRPKLTSGKLSGINEI 483
           P   P L  SS+ +LT SS+  PT TP S  T+ P   P    +SRP LT      +   
Sbjct: 162 PSSRPILTRSSTPTLTPSST--PTLTPSSTPTLTPSSTPTLTPSSRPILTRSSTPTLTPS 219

Query: 484 PRPFSPPVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
            RP   P ++ T  P + P+    S+ ++  SS+ +L+ +NTPT+  S  P+
Sbjct: 220 SRPILTPSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSNTPTLTPSNTPT 271



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 17/116 (14%)

Query: 433 PSLDSSSSSSLTSSSSARPT-TPLSVGTIVPPPRP------------ASRPKLTSGKLSG 479
           P+L  SS+ +LT SS+  PT TP S  T+ P  RP            +SRP LT      
Sbjct: 174 PTLTPSSTPTLTPSST--PTLTPSSTPTLTPSSRPILTRSSTPTLTPSSRPILTPSSTPT 231

Query: 480 INEIPRPFSPPVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
           +    RP     ++ T  P + P     ++ ++  S++ +L+ +NTPT+  S  P+
Sbjct: 232 LTPSSRPILTRSSTPTLTPSSTPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSSTPT 287



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 5/110 (4%)

Query: 429 PLFGPSLDSSSSSSLTSSSS---ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPR 485
           P   P L  SS+ +LT SS     R +TP    +  P   P+S P LT      +    R
Sbjct: 146 PSSRPILTRSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSSTPTLTPSSTPTLTPSSR 205

Query: 486 PFSPPVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
           P     ++ T  P + P+    S+ ++  SS   L+ ++TPT+  S  P+
Sbjct: 206 PILTRSSTPTLTPSSRPILTPSSTPTLTPSSRPILTRSSTPTLTPSSTPT 255



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 14/122 (11%)

Query: 412 PSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPT-TPLSVGTIVPPPRPASRP 470
           PS+PP     S+     P   P+L  S++ +LT SS+  PT TP S  T+ P    +SRP
Sbjct: 98  PSSPPTLT-PSNTPTLTPSNTPTLTPSNTPTLTPSST--PTLTPSSTPTLTP----SSRP 150

Query: 471 KLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSR 530
            LT      +     P S P+ + +S P   P   +  + + SS+ +L+ ++TPT+  S 
Sbjct: 151 ILTRSSTPTLT----PSSRPILTRSSTPTLTP--SSTPTLTPSSTPTLTPSSTPTLTPSS 204

Query: 531 GP 532
            P
Sbjct: 205 RP 206



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 30/106 (28%), Positives = 51/106 (48%), Gaps = 5/106 (4%)

Query: 433 PSLDSSSSSSLTSSSSARPT---TPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSP 489
           P+L  SS  +LT S++   T   TP    +  P   P+S P LT      +    RP   
Sbjct: 94  PTLTPSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPTLTPSSRPILT 153

Query: 490 PVTSNTSPPPAAPLARAESSSSI--SSSASLSAANTPTVGVSRGPS 533
             ++ T  P + P+    S+ ++  SS+ +L+ ++TPT+  S  P+
Sbjct: 154 RSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSSTPTLTPSSTPT 199



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 3/108 (2%)

Query: 429 PLFGPSLDSSSSSSLTSSSS---ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPR 485
           P   P+L  SS+ +LT SS     R +TP    +  P   P++ P LT      +     
Sbjct: 12  PSSPPTLTPSSTPTLTPSSQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPTLTPSST 71

Query: 486 PFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPS 533
           P   P ++ T  P       +  + + SS  +L+ +NTPT+  S  P+
Sbjct: 72  PTLTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPSNTPTLTPSNTPT 119



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 44/161 (27%), Positives = 73/161 (45%), Gaps = 14/161 (8%)

Query: 388 PAISRHSPVQMNRNLSNEELTKSK-PSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSS 446
           P ++R S   +  + S   LT+S  P+  P+   T       P   P+L  SS+ +LT S
Sbjct: 150 PILTRSSTPTLTPS-SRPILTRSSTPTLTPSSTPTLT-----PSSTPTLTPSSTPTLTPS 203

Query: 447 SS---ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPL 503
           S     R +TP    +  P   P+S P LT      +     P   P ++ T  P   P 
Sbjct: 204 SRPILTRSSTPTLTPSSRPILTPSSTPTLTPSSRPILTRSSTPTLTPSSTPTLTPSNTPT 263

Query: 504 ARAESSSSI--SSSASLSAANTPTVGVSRGP--SPVSLGNQ 540
               ++ ++  S++ +L+ ++TPT+  S  P  +P SL +Q
Sbjct: 264 LTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPTLTPSSLWHQ 304



 Score = 37.0 bits (84), Expect = 0.073
 Identities = 31/108 (28%), Positives = 51/108 (47%), Gaps = 17/108 (15%)

Query: 429 PLFGPSLDSSSSSSLTSSSSARPT---TPLSVGTIVPPPRPASRPKLTSGKLSGINEIPR 485
           P   P+L  S++ +LT S++   T   TP    +  P   P+S P LT            
Sbjct: 98  PSSPPTLTPSNTPTLTPSNTPTLTPSNTPTLTPSSTPTLTPSSTPTLT------------ 145

Query: 486 PFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPS 533
           P S P+ + +S P   P +R   +   SS+ +L+ ++TPT+  S  P+
Sbjct: 146 PSSRPILTRSSTPTLTPSSRPILTR--SSTPTLTPSSTPTLTPSSTPT 191



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 37/144 (25%), Positives = 60/144 (41%), Gaps = 19/144 (13%)

Query: 453 TPLSVGTIVP--PPR--PASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAES 508
           TP +  T+ P  PP   P+S P LT            P S P+ + +S P   P   +  
Sbjct: 3   TPSNTPTLTPSSPPTLTPSSTPTLT------------PSSQPILTRSSTPTLTP--SSPP 48

Query: 509 SSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVK 568
           + + S++ +L+ +NTPT+  S  P+ ++  +  TL     LT S       + P      
Sbjct: 49  TLTPSNTPTLTPSNTPTLTPSSTPT-LTPSSTPTLTPQPILTRSSTPTLTPSSPPTLTPS 107

Query: 569 ITGDMTMSFPSGIIKVFTSNPTPA 592
            T  +T S    +    T   TP+
Sbjct: 108 NTPTLTPSNTPTLTPSNTPTLTPS 131


>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 45/183 (24%), Positives = 73/183 (39%), Gaps = 7/183 (3%)

Query: 370 TMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDP 429
           T++S + +  S    TL+P    +SP   +   +    + + P APP+     +  A  P
Sbjct: 138 TISSRENVNTSSSVATLAPV---NSPAPQDTTAAPPTPSATTP-APPSSSAPPETTAAPP 193

Query: 430 LFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSP 489
               +  +  SSS    ++A P TP +  T   PP  ++ P+ T+   +     P P S 
Sbjct: 194 TPSATTQAPPSSSAPPETTAAPPTPPA--TTPAPPSSSAPPETTAAPPTPSATTPAPLSS 251

Query: 490 PVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVAL 549
                T+  P  P A     SS S+    +AA  PT   +    P S   Q+T    +  
Sbjct: 252 SAPPETTAVPPTPSATTLDPSSASAPPETTAA-PPTPSATTPAPPSSPAPQETTAAPITT 310

Query: 550 TES 552
             S
Sbjct: 311 PNS 313



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 35/142 (24%), Positives = 59/142 (41%), Gaps = 13/142 (9%)

Query: 414 APPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARP-----TTPLSVGTIVPPPRPAS 468
           APP+     +  A  P    +  +  SSS    ++A P     TTP  + +  PP   A 
Sbjct: 201 APPSSSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAV 260

Query: 469 RPKLTSGKLSGINEIPRP---FSPPVTSNTSP-PPAAPLARAESSSSI----SSSASLSA 520
            P  ++  L   +    P    +PP  S T+P PP++P  +  +++ I    SS  +L+ 
Sbjct: 261 PPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAP 320

Query: 521 ANTPTVGVSRGPSPVSLGNQDT 542
             + T       +  S+  Q T
Sbjct: 321 DTSETSAAPTHQTTTSVTTQTT 342



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 3/104 (2%)

Query: 433 PSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVT 492
           P++     ++ T SS     T  SV T+ P   PA +   T+   +     P P S    
Sbjct: 127 PNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAPQ-DTTAAPPTPSATTPAPPSSSAP 185

Query: 493 SNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVS 536
             T+  P  P A  ++  S S+    +AA  P    +  P+P S
Sbjct: 186 PETTAAPPTPSATTQAPPSSSAPPETTAA--PPTPPATTPAPPS 227


>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 45/183 (24%), Positives = 73/183 (39%), Gaps = 7/183 (3%)

Query: 370 TMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDP 429
           T++S + +  S    TL+P    +SP   +   +    + + P APP+     +  A  P
Sbjct: 138 TISSRENVNTSSSVATLAPV---NSPAPQDTTAAPPTPSATTP-APPSSSAPPETTAAPP 193

Query: 430 LFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSP 489
               +  +  SSS    ++A P TP +  T   PP  ++ P+ T+   +     P P S 
Sbjct: 194 TPSATTQAPPSSSAPPETTAAPPTPPA--TTPAPPSSSAPPETTAAPPTPSATTPAPLSS 251

Query: 490 PVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVAL 549
                T+  P  P A     SS S+    +AA  PT   +    P S   Q+T    +  
Sbjct: 252 SAPPETTAVPPTPSATTLDPSSASAPPETTAA-PPTPSATTPAPPSSPAPQETTAAPITT 310

Query: 550 TES 552
             S
Sbjct: 311 PNS 313



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 35/142 (24%), Positives = 59/142 (41%), Gaps = 13/142 (9%)

Query: 414 APPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARP-----TTPLSVGTIVPPPRPAS 468
           APP+     +  A  P    +  +  SSS    ++A P     TTP  + +  PP   A 
Sbjct: 201 APPSSSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAV 260

Query: 469 RPKLTSGKLSGINEIPRP---FSPPVTSNTSP-PPAAPLARAESSSSI----SSSASLSA 520
            P  ++  L   +    P    +PP  S T+P PP++P  +  +++ I    SS  +L+ 
Sbjct: 261 PPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAP 320

Query: 521 ANTPTVGVSRGPSPVSLGNQDT 542
             + T       +  S+  Q T
Sbjct: 321 DTSETSAAPTHQTTTSVTTQTT 342



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 3/104 (2%)

Query: 433 PSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVT 492
           P++     ++ T SS     T  SV T+ P   PA +   T+   +     P P S    
Sbjct: 127 PNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAPQ-DTTAAPPTPSATTPAPPSSSAP 185

Query: 493 SNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVS 536
             T+  P  P A  ++  S S+    +AA  P    +  P+P S
Sbjct: 186 PETTAAPPTPSATTQAPPSSSAPPETTAA--PPTPPATTPAPPS 227


>gi|222418645 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 45/183 (24%), Positives = 73/183 (39%), Gaps = 7/183 (3%)

Query: 370 TMASLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDP 429
           T++S + +  S    TL+P    +SP   +   +    + + P APP+     +  A  P
Sbjct: 138 TISSRENVNTSSSVATLAPV---NSPAPQDTTAAPPTPSATTP-APPSSSAPPETTAAPP 193

Query: 430 LFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSP 489
               +  +  SSS    ++A P TP +  T   PP  ++ P+ T+   +     P P S 
Sbjct: 194 TPSATTQAPPSSSAPPETTAAPPTPPA--TTPAPPSSSAPPETTAAPPTPSATTPAPLSS 251

Query: 490 PVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVAL 549
                T+  P  P A     SS S+    +AA  PT   +    P S   Q+T    +  
Sbjct: 252 SAPPETTAVPPTPSATTLDPSSASAPPETTAA-PPTPSATTPAPPSSPAPQETTAAPITT 310

Query: 550 TES 552
             S
Sbjct: 311 PNS 313



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 35/142 (24%), Positives = 59/142 (41%), Gaps = 13/142 (9%)

Query: 414 APPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARP-----TTPLSVGTIVPPPRPAS 468
           APP+     +  A  P    +  +  SSS    ++A P     TTP  + +  PP   A 
Sbjct: 201 APPSSSAPPETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAV 260

Query: 469 RPKLTSGKLSGINEIPRP---FSPPVTSNTSP-PPAAPLARAESSSSI----SSSASLSA 520
            P  ++  L   +    P    +PP  S T+P PP++P  +  +++ I    SS  +L+ 
Sbjct: 261 PPTPSATTLDPSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAP 320

Query: 521 ANTPTVGVSRGPSPVSLGNQDT 542
             + T       +  S+  Q T
Sbjct: 321 DTSETSAAPTHQTTTSVTTQTT 342



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 27/104 (25%), Positives = 42/104 (40%), Gaps = 3/104 (2%)

Query: 433 PSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVT 492
           P++     ++ T SS     T  SV T+ P   PA +   T+   +     P P S    
Sbjct: 127 PNVTFLPQNATTISSRENVNTSSSVATLAPVNSPAPQ-DTTAAPPTPSATTPAPPSSSAP 185

Query: 493 SNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVS 536
             T+  P  P A  ++  S S+    +AA  P    +  P+P S
Sbjct: 186 PETTAAPPTPSATTQAPPSSSAPPETTAA--PPTPPATTPAPPS 227


>gi|24430146 nucleoporin 153kDa [Homo sapiens]
          Length = 1475

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 65/288 (22%), Positives = 95/288 (32%), Gaps = 30/288 (10%)

Query: 330  NQNDTKENHFYS-SSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLSP 388
            ++N +K    +S +  S+ E E+P K               T A     K     +  S 
Sbjct: 1143 DENSSKSTFSFSMTKPSEKESEQPAKATFAF-----GAQTSTTADQGAAKPVFSFLNNSS 1197

Query: 389  AISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSS 448
            + S          +     + S P       G S        FG + +SS+S SL  S  
Sbjct: 1198 SSSSTPATSAGGGIFGSSTSSSNPPVATFVFGQSSNPVSSSAFGNTAESSTSQSLLFSQD 1257

Query: 449  ARPTTPLSVGTIVPP----PRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP--PPAAP 502
            ++  T  S GT V P    P  +S    TSG   G               T P  P A+P
Sbjct: 1258 SKLATTSSTGTAVTPFVFGPGASSNNTTTSGFGFGATTTSSSAGSSFVFGTGPSAPSASP 1317

Query: 503  LARAESSSSISSSASLSAANTPTVG----------VSRGPSPVSLG--NQDTLPVAVALT 550
               A  + +   S   S  N P  G              P+P + G  +  + P      
Sbjct: 1318 AFGANQTPTFGQSQGASQPNPPGFGSISSSTALFPTGSQPAPPTFGTVSSSSQPPVFGQQ 1377

Query: 551  ESVNAYFKGADPTKCIVKITGDMTMSF------PSGIIKVFTSNPTPA 592
             S +A+  G  P        G  T +F      PSG+     ++ TPA
Sbjct: 1378 PSQSAFGSGTTPNSSSAFQFGSSTTNFNFTNNSPSGVFTFGANSSTPA 1425


>gi|89886447 nitric oxide synthase trafficker isoform 2 [Homo
           sapiens]
          Length = 506

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 71/312 (22%), Positives = 128/312 (41%), Gaps = 33/312 (10%)

Query: 18  FDVLYHNMK----HGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQ---LGTFA 70
           ++ +Y N+K    +G+   K++   +++RA +E +Y++ + KLA   S   Q       +
Sbjct: 10  YNKVYKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQNTRKSCVS 69

Query: 71  PVWDVFKTSTEKLANCHLDLVRKLQ-ELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQTI 129
             W       +  A+ H  L + ++ E IK   +    Q K  K    EV  T   V  I
Sbjct: 70  SAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLV--I 127

Query: 130 QSITQALQKSKENYNAKCVEQERL------KKEGATQREIEKAAVKSKKATDTYKLYVEK 183
            +  Q + K+K+       + E L       K+  T++E  K   K  K+T+  +   E 
Sbjct: 128 SNWNQQI-KAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDEN 186

Query: 184 Y---ALAKADFEQKMTETAQK-FQDIEETHLIHIKEIIGSLSNAIKEIHLQIGQV----H 235
           Y    +A      K   T +  +Q I E     I+ +  +L+   + I L  GQ     H
Sbjct: 187 YYQKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISL-FGQTLTTCH 245

Query: 236 EEFINNMANTTVESLIQKFAESKG----TGKERPGLIEFEECDTASAVEGIKPRKRKTFA 291
            +    ++   +E  IQ   E         K    L ++ E D  SA++     +RK+  
Sbjct: 246 TQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMD---KERRKSLL 302

Query: 292 LPGIIKKEKDAE 303
            P +++ ++D E
Sbjct: 303 KPKLLRLQRDIE 314


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 61/252 (24%), Positives = 99/252 (39%), Gaps = 22/252 (8%)

Query: 271 EECDTASAVEGIKPRKRKTFALPGIIKKEKDAESVE---CPDADSLNIPDVDEEGYSIKP 327
           EE   + + E   P+K KT       +   D +S++     D  S +  D+D++  S  P
Sbjct: 74  EEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSP 133

Query: 328 ETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLS 387
                 + EN   SSS        P        P+ P +     ++  + + S       
Sbjct: 134 SIYSPGSVENDSDSSSGLSQGPARP----YHPPPLFPPSPQPPDSTPRQPEASFEPHPSV 189

Query: 388 PAISRHSPVQMNRNLSNEELTKSKPSAPPNEK-----GTSDLLAWDPLFGPSLDSSSSSS 442
                H+P++         + ++ P APP        GT  +L+  P+ GP    ++SS 
Sbjct: 190 TPTGYHAPMEP----PTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPM-GPKGGGAASSV 244

Query: 443 LTSSSSAR---PTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFS-PPVTSNTSPP 498
              +   +   PTTP+SV +      P ++P  T      +   P P + P VT N  PP
Sbjct: 245 GGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPP 304

Query: 499 PA-APLARAESS 509
           PA  PL  A +S
Sbjct: 305 PALRPLNNASAS 316



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 33/113 (29%), Positives = 47/113 (41%), Gaps = 22/113 (19%)

Query: 434 SLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTS 493
           S  SSS+++ +SSSS+  +      +   P  P S P  TS  LS  N+ P+   P + S
Sbjct: 377 SSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS--LSVSNQPPKYTQPSLPS 434

Query: 494 ----NTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDT 542
               +  PPP  P  R  ++S+                   GP P S G Q T
Sbjct: 435 QAVWSQGPPPPPPYGRLLANSN----------------AHPGPFPPSTGAQST 471



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 29/114 (25%), Positives = 41/114 (35%), Gaps = 9/114 (7%)

Query: 429 PLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLS------GINE 482
           P +G    S  +    +    +P +P S  T  PP    + P    G         G   
Sbjct: 637 PPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGP 696

Query: 483 IPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTP--TVGVSRGPSP 534
           +P P  P    +  PPPAAP +    S++           TP   V  +R PSP
Sbjct: 697 LP-PAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSP 749


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 61/252 (24%), Positives = 99/252 (39%), Gaps = 22/252 (8%)

Query: 271 EECDTASAVEGIKPRKRKTFALPGIIKKEKDAESVE---CPDADSLNIPDVDEEGYSIKP 327
           EE   + + E   P+K KT       +   D +S++     D  S +  D+D++  S  P
Sbjct: 74  EEISESESEETNAPKKTKTEQELPRPQSPSDLDSLDGRSLNDDGSSDPRDIDQDNRSTSP 133

Query: 328 ETNQNDTKENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLS 387
                 + EN   SSS        P        P+ P +     ++  + + S       
Sbjct: 134 SIYSPGSVENDSDSSSGLSQGPARP----YHPPPLFPPSPQPPDSTPRQPEASFEPHPSV 189

Query: 388 PAISRHSPVQMNRNLSNEELTKSKPSAPPNEK-----GTSDLLAWDPLFGPSLDSSSSSS 442
                H+P++         + ++ P APP        GT  +L+  P+ GP    ++SS 
Sbjct: 190 TPTGYHAPMEP----PTSRMFQAPPGAPPPHPQLYPGGTGGVLSGPPM-GPKGGGAASSV 244

Query: 443 LTSSSSAR---PTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFS-PPVTSNTSPP 498
              +   +   PTTP+SV +      P ++P  T      +   P P + P VT N  PP
Sbjct: 245 GGPNGGKQHPPPTTPISVSSSGASGAPPTKPPTTPVGGGNLPSAPPPANFPHVTPNLPPP 304

Query: 499 PA-APLARAESS 509
           PA  PL  A +S
Sbjct: 305 PALRPLNNASAS 316



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 33/113 (29%), Positives = 47/113 (41%), Gaps = 22/113 (19%)

Query: 434 SLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTS 493
           S  SSS+++ +SSSS+  +      +   P  P S P  TS  LS  N+ P+   P + S
Sbjct: 377 SSSSSSAAASSSSSSSSSSASPFPASQALPSYPHSFPPPTS--LSVSNQPPKYTQPSLPS 434

Query: 494 ----NTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDT 542
               +  PPP  P  R  ++S+                   GP P S G Q T
Sbjct: 435 QAVWSQGPPPPPPYGRLLANSN----------------AHPGPFPPSTGAQST 471



 Score = 31.6 bits (70), Expect = 3.1
 Identities = 29/114 (25%), Positives = 41/114 (35%), Gaps = 9/114 (7%)

Query: 429 PLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLS------GINE 482
           P +G    S  +    +    +P +P S  T  PP    + P    G         G   
Sbjct: 637 PPYGKRAPSPGAYKTATPPGYKPGSPPSFRTGTPPGYRGTSPPAGPGTFKPGSPTVGPGP 696

Query: 483 IPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTP--TVGVSRGPSP 534
           +P P  P    +  PPPAAP +    S++           TP   V  +R PSP
Sbjct: 697 LP-PAGPSGLPSLPPPPAAPASGPPLSATQIKQEPAEEYETPESPVPPARSPSP 749


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 55/221 (24%), Positives = 99/221 (44%), Gaps = 26/221 (11%)

Query: 41  ERATIEEAYSR-SMTKLAKSASNYSQLGTFAPVWDVFKTSTEKLANCHLDLVRKLQELIK 99
           ERA  EE     S  +  + A    +      +  + KTS E+  +   +L R  QE++ 
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468

Query: 100 EVQKYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQERLKKEGAT 159
            ++K  EEQ+   +K  E+     E  +  Q +T+ LQ  +  +      QE++K     
Sbjct: 469 VMKKSSEEQIAKLQKLHEK-----ELARKEQELTKKLQTREREF------QEQMKV---- 513

Query: 160 QREIEKAAVKSKKATDTYKLYVEKYALAKADFEQK--MTETAQKFQDIE---ETHLIHIK 214
              +EK+  +  K +   K   E  AL + + ++K  +TE+  K +D++   ET+   I 
Sbjct: 514 --ALEKSQSEYLKISQE-KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRIL 570

Query: 215 EIIGSLSNAIKEIHLQIGQ--VHEEFINNMANTTVESLIQK 253
           E+  SL  +++E   Q     VH E   N  N  +  +++K
Sbjct: 571 ELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEK 611



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 68/344 (19%), Positives = 134/344 (38%), Gaps = 55/344 (15%)

Query: 74   DVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQTIQSI- 132
            DV KT  EK   C +     L++ IKE+      Q + H+   EE+    E +Q +Q + 
Sbjct: 1837 DVQKTLQEKELTCQI-----LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMD 1891

Query: 133  -----TQALQKSKENYNAKCVEQERLK------------KEGATQREIEKAAVK----SK 171
                 T+ L+++ E  +   + Q +L             K    +RE +K   +     K
Sbjct: 1892 GRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQK 1951

Query: 172  KATDTYKLYVEKYALAKADFEQKMTE-TAQKFQDIEETHLIHIKEIIGSLSNAIKEIHLQ 230
                  K + ++  + K +++Q+  E   Q+ +D+E  H   +K+++   +  + +   +
Sbjct: 1952 DLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011

Query: 231  IGQVHEEFINNMANTTVE----------SLIQKFAES----KGTGKERPGLIEFEECDTA 276
            +    +E IN       E           L++K AE     K T K    +++  E +  
Sbjct: 2012 LEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMT 2071

Query: 277  SAVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGYSIKPETNQNDTKE 336
            + V  ++ +  +        K ++  E  E P  D++ I ++  +        + +  KE
Sbjct: 2072 AKVRDLQTQLEELQK-----KYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126

Query: 337  NHFYSSSDSDSEDEEPKKYRIEI------KPMHPNNSHHTMASL 374
              F       + ++  KKY   +       P    N +HT  SL
Sbjct: 2127 QEF--REQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSL 2168



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 69/351 (19%), Positives = 138/351 (39%), Gaps = 31/351 (8%)

Query: 93   KLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQTIQSITQALQKSKENYNAKCVEQER 152
            ++Q+L+++++K   E  +  K   +     LE     Q  T+ +   KEN   +  E ++
Sbjct: 862  QVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQK 921

Query: 153  LKKEGATQREIEKAAVKSKKATDTYKLYVEKYALAKADFEQKMTETAQKFQDIEETHLIH 212
                    +EIE    K     D+  +  E+Y     + E+KM +  QK ++++ET    
Sbjct: 922  --------KEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK 973

Query: 213  IKEIIGSLSNAIKEIHLQIGQVHEEF---INNMANTTVESLIQKFAESKGTGKER-PGLI 268
            + +    L   ++   L++ Q  ++F   +  MA      +    +  +   KE+   L 
Sbjct: 974  LLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLT 1033

Query: 269  EFEECDTASAV----EGIKPRKRKTFALPGIIKKEKDAESVECP--------DADSLN-- 314
            E    +    +    + +  +  +   +  I  +EK+ E  E          + + +N  
Sbjct: 1034 EVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKE 1093

Query: 315  IPDVDEEGYSIKPETNQNDTKENHFYSSS--DSDSEDEEPKKYRIEIKPMHPNNSHHTMA 372
            I  + EEG  +K +T  N+ +E     S+  +S ++DE   K  +E   +  N S     
Sbjct: 1094 ITWLKEEG--VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENT 1151

Query: 373  SLDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSD 423
             L E  V +  +       + S +      ++EE    K S   + K   D
Sbjct: 1152 FLQEQLVEL-KMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLED 1201


>gi|111120318 NK6 transcription factor related, locus 1 [Homo
           sapiens]
          Length = 367

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 41/103 (39%), Positives = 56/103 (54%), Gaps = 9/103 (8%)

Query: 426 AWDPL-FGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPA-----SRPK-LTSGKLS 478
           A+ PL  GP   SSSSSS +SSS + P    + G + PP         S P+ L++    
Sbjct: 39  AYPPLPAGPP--SSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAATPH 96

Query: 479 GINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAA 521
           GIN+I    S PV S  + P A+P   + SSSS +S++S SAA
Sbjct: 97  GINDILSRPSMPVASGAALPSASPSGSSSSSSSSASASSASAA 139


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 102/430 (23%), Positives = 167/430 (38%), Gaps = 54/430 (12%)

Query: 377  LKVSIGNITLSPA-ISRHSPVQMNRNLSNEELTK---SKPSAPPNEKGTSDLLAWDPLFG 432
            L VS    TLS   +    PV  +   S+   T    S P++PP+E GT+ L        
Sbjct: 1112 LVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSE-GTTPLA------- 1163

Query: 433  PSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVT 492
             S+  S++  ++S ++   TTP+   T V     AS P  T+   S     P   S P+T
Sbjct: 1164 -SMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLT 1222

Query: 493  SNTSPPPAAPLARAE----------SSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ-- 540
            S   P    P+A +E          +S+ +++SA  S++ T   G S   S  S G+   
Sbjct: 1223 S--MPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLL 1280

Query: 541  DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPA-----VLC 595
             ++PV+  L  S  A             +T  +    P       +S+PTPA        
Sbjct: 1281 TSIPVSTTLVTSPEA----------STLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTS 1330

Query: 596  FRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLS----EQNPAASY 651
               +  + L  I  N  LV S      S T     N   VT   +  S     +  +   
Sbjct: 1331 TYSEGRTPLTSIPVNTTLVASSAISILSTTP--VDNSTPVTTSTEACSSPTTSEGTSMPN 1388

Query: 652  YNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVP 711
             N       ++S  + +TP+  +     SA+  D       + EA  +P+    I +   
Sbjct: 1389 SNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTS 1448

Query: 712  VDG-GVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSGSLRA-KFDLSEGPSKPTTL 769
                G T ++S+P +       +A    S++S    +  S  + +     S  P++ T++
Sbjct: 1449 TPSEGKTPLKSIPVSNTPVANSEA----STLSTTPVDSNSPVVTSTAVSSSPTPAEGTSI 1504

Query: 770  AVQFLSEGST 779
            A+   SEGST
Sbjct: 1505 AISTPSEGST 1514



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 74/349 (21%), Positives = 130/349 (37%), Gaps = 38/349 (10%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNT-- 495
            ++SS  T+  ++ PT+ LS GT      P S   + + ++S ++  P   + P T++T  
Sbjct: 2257 ATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEA 2316

Query: 496  -SPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVN 554
             SPPP A        +S+ +S S S  NTP   +    + V+     TL    A T +  
Sbjct: 2317 SSPPPTA------EGTSMPTSTS-SEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPV 2369

Query: 555  AYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLV 614
              +  A  +      T   T ++  G      S P  +V    +  +S          + 
Sbjct: 2370 TTYSQAGSSPTTADDTSMPTSTYSEG------STPLTSVPVSTMPVVSSEASTHSTTPVD 2423

Query: 615  FSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLA 674
             S P    +         +  ++     SE                ++S  + +TP+  +
Sbjct: 2424 TSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTT------------PLASMPVSTTPVVSS 2471

Query: 675  TYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPV---DGGVTNMQSLPPAIWNAEQ 731
                 S +  D       + EA  +P+   +I  VVP+     G T + S+P +      
Sbjct: 2472 EAGTLSTTPVDTSTPMTTSTEASSSPTTAEDI--VVPISTASEGSTLLTSIPVSTTPVAS 2529

Query: 732  MKA-FWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGST 779
             +A     + +   S    S  + +    +EG S PT+      SEGST
Sbjct: 2530 PEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTST----YSEGST 2574



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 42/153 (27%), Positives = 67/153 (43%), Gaps = 20/153 (13%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
            +SSSS T+  ++ PT+  S G+      P S   + S + S ++  P   S PVT++T  
Sbjct: 1079 ASSSSTTADGTSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTST-- 1136

Query: 498  PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYF 557
                     E+SSS +++   S    PT   S G +P++     ++PV+  L  S  A  
Sbjct: 1137 ---------EASSSPTTAEGTS---IPTSPPSEGTTPLA-----SMPVSTTLVVSSEANT 1179

Query: 558  KGADPTKCIVKITGDMTMSFPSGIIKVFTSNPT 590
                P     ++      S P    +V TS PT
Sbjct: 1180 LSTTPVDSKTQVATSTEASSPPPTAEV-TSMPT 1211



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 58/244 (23%), Positives = 90/244 (36%), Gaps = 39/244 (15%)

Query: 336 ENHFYSSSDSDSEDEEPKKYRIEIKPMHPNNSHHTMASLDELKVSIGNITLSPA------ 389
           E+   S S SDS    P        P  P  +   M++  E  +S     +S A      
Sbjct: 114 ESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFE 173

Query: 390 --ISRHSPVQMNRNLSNEELTKSKPSAPP--------NEKGTSDLLAWDPLFGPSLDSSS 439
              S    V M+  L+      S P+ P         N +G++ L         S+ +S+
Sbjct: 174 AYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLT--------SMPAST 225

Query: 440 SSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVT------- 492
               +S +    TTP+ + T V     AS    T+   S  N  P   S P+T       
Sbjct: 226 MKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVM 285

Query: 493 -------SNTSPPPAAPLARAESSSSISSSASLSAANT-PTVGVSRGPSPVSLGNQDTLP 544
                  S  S  PAA      +S+  SSS + +   + PT   + G +P++     T+P
Sbjct: 286 LVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMP 345

Query: 545 VAVA 548
           VA +
Sbjct: 346 VATS 349



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 86/368 (23%), Positives = 135/368 (36%), Gaps = 27/368 (7%)

Query: 374  LDELKVSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGP 433
            L  + VSI  +T SP  S  S   ++ N      T+   S  P E  +     +     P
Sbjct: 808  LTSIPVSITPVT-SPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTP 866

Query: 434  --SLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPV 491
              S+  S++   TS+ S   TTP+   T V     A     TS   S     P   S P+
Sbjct: 867  LTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPL 926

Query: 492  TS--NTSPPPAAPLARAESSSSISSS----ASLSAANTPTV--GVSRGPSPVSLGNQ--D 541
            TS  +++ P  +  AR  S++ + +S     S  A ++PT   G S   S  S G     
Sbjct: 927  TSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLT 986

Query: 542  TLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNI 601
            + PV+  L  +  A      P      +T     S P    +  TS PT        +  
Sbjct: 987  STPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAE-GTSMPTST----PSEGS 1041

Query: 602  SRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQV 661
            + L ++  +  +V S  +   S T         VT Y  + S  +  A   ++    Y  
Sbjct: 1042 TPLTRMPVSTTMVASSETSTLSTTPA--DTSTPVTTY-SQASSSSTTADGTSMPTSTYSE 1098

Query: 662  SSNGIQSTPLNLATYWKCSAST-----TDLRVDYKYNPEAMVAPSVLSNIQV-VVPVDGG 715
             S  + S P++        AST      D  +    + EA  +P+      +   P   G
Sbjct: 1099 GSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPSEG 1158

Query: 716  VTNMQSLP 723
             T + S+P
Sbjct: 1159 TTPLASMP 1166



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 47/171 (27%), Positives = 74/171 (43%), Gaps = 19/171 (11%)

Query: 390  ISRHSPVQMNRNLSNEELTK---SKPSAPPNEKGTSDLLAWDPLFGPSLDSSS------- 439
            +   +PV  +   S+   T    S P++PP+E GT+ L +      P + S +       
Sbjct: 2422 VDTSTPVTTSTEASSSPTTAEGTSIPTSPPSE-GTTPLASMPVSTTPVVSSEAGTLSTTP 2480

Query: 440  ---SSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTS 496
               S+ +T+S+ A  ++P +   IV P   AS     S  L+ I     P + P  S  S
Sbjct: 2481 VDTSTPMTTSTEAS-SSPTTAEDIVVPISTASEG---STLLTSIPVSTTPVASPEASTLS 2536

Query: 497  PPPAAPLARAESSSSISSSA-SLSAANTPTVGVSRGPSPVSLGNQDTLPVA 546
              P    +   +S+ ISSSA S    + PT   S G +P+      T P+A
Sbjct: 2537 TTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLA 2587



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 33/113 (29%), Positives = 50/113 (44%), Gaps = 7/113 (6%)

Query: 435 LDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSN 494
           +DS +  +  S +S+ PTT          P   S P LTS  +S       P +    SN
Sbjct: 418 VDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTP-LTSMPVS-----TTPVASSEASN 471

Query: 495 TSPPPAAPLARAESSSSISSSASLSAANT-PTVGVSRGPSPVSLGNQDTLPVA 546
            S  P     +  +S+  SSS   +  N+ PT   S G +P++  +  T+PVA
Sbjct: 472 LSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVA 524



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 28/106 (26%), Positives = 48/106 (45%), Gaps = 4/106 (3%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
            +SSS  T+  ++ PT+  S G+      P S   + S + S ++  P   S PVT+ +  
Sbjct: 3259 ASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQA 3318

Query: 498  PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTL 543
              + P+A   S      +++ S  +TP   +S   +PV      TL
Sbjct: 3319 SSSPPIADGTS----MPTSTYSEGSTPLTNMSFSTTPVVSSEASTL 3360



 Score = 38.5 bits (88), Expect = 0.025
 Identities = 39/146 (26%), Positives = 64/146 (43%), Gaps = 6/146 (4%)

Query: 434  SLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTS 493
            S ++SSS ++   +S  PT+  S G+      P S   + S + S ++  P   S PVT 
Sbjct: 3433 STEASSSPTIAEGTSL-PTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVT- 3490

Query: 494  NTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESV 553
             TS P  +    AE +S  +S+A     +TP   +    +PV+     TL      + + 
Sbjct: 3491 -TSSPTNSSPTTAEVTSMPTSTA--GEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTF 3547

Query: 554  NAYFKGADPTKCIVKITGDMTMSFPS 579
                  A  +   +++T  M MS PS
Sbjct: 3548 VTSSSQASSSPATLQVT-TMRMSTPS 3572



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 37/144 (25%), Positives = 58/144 (40%), Gaps = 17/144 (11%)

Query: 407  LTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRP 466
            LT    S  P     +  L+  P      D+S+  + ++ +S+ PTT    G  +  P  
Sbjct: 2989 LTSMSVSTMPVASSEASTLSRTPA-----DTSTPVTTSTEASSSPTTAEGTGIPISTPSE 3043

Query: 467  ASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTV 526
             S P      L+ I     P + P  S  S  P       +S+S + +S  +S++ TP  
Sbjct: 3044 GSTP------LTSIPVSTTPVAIPEASTLSTTP------VDSNSPVVTSTEVSSSPTPAE 3091

Query: 527  GVSRGPSPVSLGNQDTLPVAVALT 550
            G S   S  S G+     V V+ T
Sbjct: 3092 GTSMPISTYSEGSTPLTGVPVSTT 3115



 Score = 38.1 bits (87), Expect = 0.033
 Identities = 51/190 (26%), Positives = 80/190 (42%), Gaps = 20/190 (10%)

Query: 379  VSIGNITLSPAISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSS 438
            VS   +T  P  S  S   +  ++S    ++   S+P   +GT+ +        P   +S
Sbjct: 3760 VSTTPVTRFPESSTPSIPSVYTSMSMTTASEGS-SSPTTLEGTTTM--------PMSTTS 3810

Query: 439  SSSSLTSSSSARPTT---PLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSP---PVT 492
              S+L ++    P +   P    T+  PP   S P LTS K +G   IP   +     +T
Sbjct: 3811 ERSTLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTK-AGSFSIPAEVTTIRISIT 3869

Query: 493  SNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTES 552
            S  S P    L    S++  +S    S A+TP +  S   +P S     T  + VA T S
Sbjct: 3870 SERSTPLTTLLV---STTLPTSFPGASIASTPPLDTSTTFTP-STDTASTPTIPVATTIS 3925

Query: 553  VNAYFKGADP 562
            V+   +G+ P
Sbjct: 3926 VSVITEGSTP 3935



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 34/133 (25%), Positives = 60/133 (45%), Gaps = 19/133 (14%)

Query: 438 SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
           ++SSS T+  ++ PT+  + G+      P +   + S + S ++  P   S PVT++T  
Sbjct: 666 ATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTST-- 723

Query: 498 PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYF 557
                    E+SSS +++     A+ PT   S G +P++     ++PV+  L  S  A  
Sbjct: 724 ---------EASSSPTTA---DGASMPTSTPSEGSTPLT-----SMPVSKTLLTSSEAST 766

Query: 558 KGADPTKCIVKIT 570
               P      IT
Sbjct: 767 LSTTPLDTSTHIT 779



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 47/189 (24%), Positives = 75/189 (39%), Gaps = 23/189 (12%)

Query: 439  SSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPP 498
            SSS   +  ++ P +  S G+      P S   +TS  +S ++  P   S PVT++T   
Sbjct: 3084 SSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTST--- 3140

Query: 499  PAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFK 558
                   A SS + S   S+     PT   S G +P++      +PV+  L  S      
Sbjct: 3141 ------EAHSSPTTSEGTSM-----PTSTPSEGSTPLTY-----MPVSTMLVVSSEDSTL 3184

Query: 559  GADP--TKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFS 616
             A P  T   V  + + T S  +    + TS P+  +       +S        A ++ +
Sbjct: 3185 SATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILST 3244

Query: 617  DPSQCDSNT 625
             P   DSNT
Sbjct: 3245 TP--VDSNT 3251



 Score = 37.4 bits (85), Expect = 0.056
 Identities = 31/109 (28%), Positives = 50/109 (45%), Gaps = 14/109 (12%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
            +S S  T+  ++ PT+  S GT      P S   + S +++ ++  P   +  VT++T  
Sbjct: 3377 ASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTST-- 3434

Query: 498  PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVA 546
                    A SS +I+   SL     PT   S G +P+S+    T PVA
Sbjct: 3435 -------EASSSPTIAEGTSL-----PTSTTSEGSTPLSIMPLSTTPVA 3471



 Score = 37.0 bits (84), Expect = 0.073
 Identities = 52/211 (24%), Positives = 80/211 (37%), Gaps = 24/211 (11%)

Query: 394 SPVQMNRNLSNE-ELTKSKPSAPPNEKGTSDLLAWD-PLFGPSLDSSSSSSLTSSSSARP 451
           +PV  N  ++   E T S  +A      TS       PL   S+  +++   +S +S   
Sbjct: 652 TPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPL--TSMPVNTTLVASSEASTLS 709

Query: 452 TTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTS--------NTSPPPAAPL 503
           TTP+   T V     AS    T+   S     P   S P+TS         +S       
Sbjct: 710 TTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLST 769

Query: 504 ARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ--DTLPVAVALTESVNAYFKGAD 561
              ++S+ I++S   S + T T G S   S  S G+    ++PV++    S  A      
Sbjct: 770 TPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTT 829

Query: 562 PTKCIVKITGDMTMSFPSGIIKVFTSNPTPA 592
           P      +T    +S          S+PTPA
Sbjct: 830 PVDSNSPVTTSTEVS----------SSPTPA 850



 Score = 36.6 bits (83), Expect = 0.096
 Identities = 24/85 (28%), Positives = 44/85 (51%), Gaps = 1/85 (1%)

Query: 439  SSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPP 498
            SSS+ ++  ++ PT+  S G+      P S   L S + S ++  P   S PVT++T   
Sbjct: 2553 SSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTE-T 2611

Query: 499  PAAPLARAESSSSISSSASLSAANT 523
             ++P    ++S  IS+ + +S + T
Sbjct: 2612 SSSPTTAKDTSMPISTPSEVSTSLT 2636



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 33/167 (19%), Positives = 67/167 (40%), Gaps = 10/167 (5%)

Query: 389  AISRHSPVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSS 448
            +I+   P+  +   +    T S P+ P     +  ++      G ++   S+   +S++ 
Sbjct: 3893 SIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGSTPGTTIFIPSTPVTSSTAD 3952

Query: 449  ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP--------PPA 500
              P T  +V T V      + P  +S   +      + F+ P  +  +P         P+
Sbjct: 3953 VFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPS 4012

Query: 501  APLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAV 547
             P  R  S    +S+++LSA +TP    S    PV+  ++ + P  +
Sbjct: 4013 TP--RTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTI 4057



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 30/109 (27%), Positives = 48/109 (44%), Gaps = 3/109 (2%)

Query: 438 SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
           +SSS  T+  ++ PT+  + G+      PAS   + + ++S ++  P   S  VT++T P
Sbjct: 312 ASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEP 371

Query: 498 PPAAPLARAESS-SSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPV 545
                 A A S  +S  S  S    N P   +    S  S     T+PV
Sbjct: 372 SSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEAS--TTSTIPV 418



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 4/123 (3%)

Query: 421 TSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGI 480
           TS +      F  +   +SSS  T+  ++  T+  S G+      P S   + S + S +
Sbjct: 413 TSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEASNL 472

Query: 481 NEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ 540
           +  P      VT++T    + P A   S      +++ S  +TP   +S    PV+    
Sbjct: 473 STTPVDSKTQVTTSTEASSSPPTAEVNS----MPTSTPSEGSTPLTSMSVSTMPVASSEA 528

Query: 541 DTL 543
            TL
Sbjct: 529 STL 531



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 37/154 (24%), Positives = 62/154 (40%), Gaps = 22/154 (14%)

Query: 440  SSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPP 499
            SS  TS  ++ P +  S GT      P S   + S + S ++  P   S PVT++T    
Sbjct: 1729 SSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTST---- 1784

Query: 500  AAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVA---VALTESVNAY 556
                       + SS  +    + PT  +S G +P++     + PV+   VA +E+    
Sbjct: 1785 ----------EATSSPTTAEGTSIPTSTLSEGMTPLT-----STPVSHTLVANSEASTLS 1829

Query: 557  FKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPT 590
                D    +V  T   +   P+    + TS P+
Sbjct: 1830 TTPVDSNSPVVTSTAVSSSPTPAEGTSIATSTPS 1863



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 5/97 (5%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNT-- 495
            ++SS  T+  ++ PT+ LS G       P S   + + + S ++  P   + PV ++T  
Sbjct: 1786 ATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAV 1845

Query: 496  --SPPPAAPLARAESSSSISSSASLS-AANTPTVGVS 529
              SP PA   + A S+ S  S+A  S   +T TV  S
Sbjct: 1846 SSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASS 1882



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 31/144 (21%), Positives = 59/144 (40%), Gaps = 4/144 (2%)

Query: 437  SSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTS 496
            + ++SS T+  ++ PT+  S G       P S   + S + S ++  P   + P+T++T 
Sbjct: 3199 TEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTE 3258

Query: 497  PPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAY 556
               + P A   S      +++ S  +TP   +    + V+     TL    A T +    
Sbjct: 3259 ASSSPPTAEGTS----MPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVTT 3314

Query: 557  FKGADPTKCIVKITGDMTMSFPSG 580
            +  A  +  I   T   T ++  G
Sbjct: 3315 YSQASSSPPIADGTSMPTSTYSEG 3338



 Score = 35.0 bits (79), Expect = 0.28
 Identities = 40/155 (25%), Positives = 65/155 (41%), Gaps = 12/155 (7%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
            +SSS  T+  ++ PT   S G+      P S   + S + S ++  P   S P T++T  
Sbjct: 1963 ASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEG 2022

Query: 498  PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYF 557
              +   A     +SI +S   S   TP  G+    + V     +TL      T  V++  
Sbjct: 2023 SSSPTTA---GGTSIQTSTP-SERTTPLAGMPVSTTLVVSSEGNTLS-----TTPVDSKT 2073

Query: 558  KGADPTKCIVKITGD---MTMSFPSGIIKVFTSNP 589
            +  + T+     T +   MT+S PS    + TS P
Sbjct: 2074 QVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIP 2108



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 64/294 (21%), Positives = 105/294 (35%), Gaps = 37/294 (12%)

Query: 438 SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
           +SSS  T+  ++ PT+  S G+        S   + S + S ++  P   S PVT+    
Sbjct: 489 ASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTT---- 544

Query: 498 PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYF 557
                     SS + SSS +    + PT   S G +P++      +PV+  L  S  A  
Sbjct: 545 ----------SSEASSSSTTPEGTSIPTSTPSEGSTPLT-----NMPVSTRLVVSSEAST 589

Query: 558 KGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTP--AVLCFRVKNISRLEQILPNAQLVF 615
               P      +T     S  S      TS PT   +     + ++S    ++ +++   
Sbjct: 590 TSTTPADSNTFVTTSSEAS-SSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEAST 648

Query: 616 SDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLAT 675
              +  DSNT         VT   +  S    A    ++    Y   S  + S P+N   
Sbjct: 649 LSTTPVDSNT--------PVTTSTEATSSSTTAEG-TSMPTSTYTEGSTPLTSMPVNTTL 699

Query: 676 YWKCSAST-----TDLRVDYKYNPEAMVAPSVLSNIQVVVPVDG-GVTNMQSLP 723
                AST      D       + EA  +P+      +       G T + S+P
Sbjct: 700 VASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMP 753



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 75/352 (21%), Positives = 125/352 (35%), Gaps = 46/352 (13%)

Query: 440  SSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPP 499
            SS  TS  ++ PT+  S G+      P S   + + + S ++  P   S PVT++T    
Sbjct: 2200 SSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTST---- 2255

Query: 500  AAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKG 559
                       + SS  +    + PT  +S G +P++     ++PV+  L  +       
Sbjct: 2256 ----------EATSSPTTAEGTSIPTSTLSEGTTPLT-----SIPVSHTLVANSEVSTLS 2300

Query: 560  ADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPS 619
              P       T     S P    +  TS PT        +  + L ++  +  +V S  +
Sbjct: 2301 TTPVDSNTPFTTSTEASSPPPTAE-GTSMPTST----SSEGNTPLTRMPVSTTMVASFET 2355

Query: 620  QCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKC 679
               S T         VT Y  +       A   ++    Y   S  + S P++       
Sbjct: 2356 STLSTTPA--DTSTPVTTY-SQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSS 2412

Query: 680  SAST-----TDLRVDYKYNPEAMVAPSVLSNIQV-VVPVDGGVTNMQSLPPAIWNAEQMK 733
             AST      D       + EA  +P+      +   P   G T + S+P +       +
Sbjct: 2413 EASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSE 2472

Query: 734  AFWKLSSISEKSENGGSGSLRAKFDLSEGPSKPTT-----LAVQFLSEGSTL 780
            A   LS+    +    + S       +E  S PTT     + +   SEGSTL
Sbjct: 2473 A-GTLSTTPVDTSTPMTTS-------TEASSSPTTAEDIVVPISTASEGSTL 2516



 Score = 34.3 bits (77), Expect = 0.48
 Identities = 39/176 (22%), Positives = 64/176 (36%), Gaps = 31/176 (17%)

Query: 395 PVQMNRNLSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTP 454
           PV     +S+E  T S   A  N             F  +   +SSSS T+  ++ PT+ 
Sbjct: 576 PVSTRLVVSSEASTTSTTPADSNT------------FVTTSSEASSSSTTAEGTSMPTST 623

Query: 455 LSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISS 514
            S           S   + S + S ++  P   + PVT++T               + SS
Sbjct: 624 YSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTST--------------EATSS 669

Query: 515 SASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKIT 570
           S +    + PT   + G +P++     ++PV   L  S  A      P      +T
Sbjct: 670 STTAEGTSMPTSTYTEGSTPLT-----SMPVNTTLVASSEASTLSTTPVDTSTPVT 720



 Score = 34.3 bits (77), Expect = 0.48
 Identities = 44/179 (24%), Positives = 67/179 (37%), Gaps = 26/179 (14%)

Query: 402  LSNEELTKSKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTS-----------SSSAR 450
            LS   +  S P     E  +S   A D     S  S  S+SLTS            +S  
Sbjct: 2594 LSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTL 2653

Query: 451  PTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTS--------NTSPPPAAP 502
             TTP+   T+V      S    T+   S     P   S P+T+          S      
Sbjct: 2654 STTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLS 2713

Query: 503  LARAESSSSISSSASLSAANTPTVGVSR-------GPSPVSLGNQDTLPVAVALTESVN 554
                ++S+ +++SA  S++ T   G S        G +P++     TLPVA +   +V+
Sbjct: 2714 TTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVS 2772



 Score = 34.3 bits (77), Expect = 0.48
 Identities = 36/118 (30%), Positives = 48/118 (40%), Gaps = 31/118 (26%)

Query: 437  SSSSSSLTSSSS------------ARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIP 484
            S+SSSS T+S S            A P T +++ T    PR  SR   TS         P
Sbjct: 3975 STSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTP 4034

Query: 485  --------RPFSP--------PVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTV 526
                    RP +P         +TS+T PP   P   A SS+  ++SAS +  N   V
Sbjct: 4035 HTSTSVTTRPVTPSSESSRPSTITSHTIPPTFPP---AHSSTPPTTSASSTTVNPEAV 4089



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 81/388 (20%), Positives = 140/388 (36%), Gaps = 40/388 (10%)

Query: 410 SKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASR 469
           S P++ P+E  T       PL   S+  S+    +S +S   TTP+   T V     AS 
Sbjct: 500 SMPTSTPSEGST-------PL--TSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASS 550

Query: 470 PKLTSGKLSGINEIPRPFSPPVTSN--------TSPPPAAPLARAESSSSISSSASLSAA 521
              T    S     P   S P+T+         +S         A+S++ +++S+  S++
Sbjct: 551 SSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSS 610

Query: 522 NTPTVGVSRGPSPVSLGNQ--DTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPS 579
           +T   G S   S  S       ++ V+  L  S  A      P      +T   T +  S
Sbjct: 611 STTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVT-TSTEATSS 669

Query: 580 GIIKVFTSNPTPAVLCFRVKNISRLEQILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYL 639
                 TS PT        +  + L  +  N  LV S  +   S T    ++        
Sbjct: 670 STTAEGTSMPTSTY----TEGSTPLTSMPVNTTLVASSEASTLSTTP---VDTSTPVTTS 722

Query: 640 KKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSAST-----TDLRVDYKYNP 694
            + S     A   ++        S  + S P++        AST      D       + 
Sbjct: 723 TEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTST 782

Query: 695 EAMVAPSVL--SNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSSISEKSENGGSG- 751
           EA  +P+    +++ +  P +G    + S+P +I      +A    S++S    +  S  
Sbjct: 783 EASCSPTTTEGTSMPISTPSEGSPL-LTSIPVSITPVTSPEA----STLSTTPVDSNSPV 837

Query: 752 SLRAKFDLSEGPSKPTTLAVQFLSEGST 779
           +   +   S  P++ T++     SEG T
Sbjct: 838 TTSTEVSSSPTPAEGTSMPTSTYSEGRT 865



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 62/291 (21%), Positives = 107/291 (36%), Gaps = 43/291 (14%)

Query: 434  SLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTS 493
            S+  +++   +S+ S   TTP+   T V     A     TS   S  N  P   + P+TS
Sbjct: 1341 SIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTS 1400

Query: 494  ---NTSP---PPAAPLARAESSSSISSSASLSAANTPTV--GVSRGPSPVSLGNQDTLPV 545
               +T+P     A+ L+     +S   + S  A ++PT   G+S   S  S G      +
Sbjct: 1401 IPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSI 1460

Query: 546  AVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTPAVLCFRVKNISRLE 605
             V+ T   N        ++     T  +  + P       +S+PTPA             
Sbjct: 1461 PVSNTPVAN--------SEASTLSTTPVDSNSPVVTSTAVSSSPTPA------------- 1499

Query: 606  QILPNAQLVFSDPSQCDSNTKDFWMNMQAVTVYLKKLSEQNPAASYYNVDVLKYQVSSNG 665
                   +  S PS  + +T    + +   TV   +++  +   +  +  V  Y  +S+ 
Sbjct: 1500 ---EGTSIAISTPS--EGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSS 1554

Query: 666  ---IQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVD 713
                  T +  +TY + S   T L V        M+  S  +N     P+D
Sbjct: 1555 PTTADGTSMQTSTYSEGSTPLTSLPV------STMLVVSSEANTLSTTPID 1599



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 39/152 (25%), Positives = 61/152 (40%), Gaps = 31/152 (20%)

Query: 421  TSDLLAWDPLFGPSLDSSSSSSLTS----------SSSARPTTPLSVGTIVPPPR----- 465
            TS  L+  P+  P   + S++ + S          SSS  PT   S+ T     R     
Sbjct: 2105 TSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLT 2164

Query: 466  --PASRPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANT 523
              P S   + S  +S ++  P   S PVT++T          A SS + S   S+     
Sbjct: 2165 SMPVSTTVVASSAISTLSTTPVDTSTPVTNST---------EARSSPTTSEGTSM----- 2210

Query: 524  PTVGVSRGPSPVSLGNQDTLPVAVALTESVNA 555
            PT   S G +P +     T+PV  +   +++A
Sbjct: 2211 PTSTPSEGSTPFTSMPVSTMPVVTSEASTLSA 2242



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 4/106 (3%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
            +SSS  T+     P +  S G+ +    P S   + S + S ++  P   S PVT++T  
Sbjct: 2847 ASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTE- 2905

Query: 498  PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTL 543
              ++P     +S  IS+ + +S   TP   +     PV+     TL
Sbjct: 2906 GSSSPTTAEGTSMPISTPSEVS---TPLTSILVSTVPVAGSEASTL 2948



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 18/184 (9%)

Query: 413  SAPPNEKGTSDLLAWDPLFGP----SLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPAS 468
            S+P   +GTS +    P  G     S+  S+++  +S ++   TTP    T V      S
Sbjct: 1847 SSPTPAEGTS-IATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVS 1905

Query: 469  RPKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGV 528
                T+   S     PR   PP+TS   P     +A +E +   + S +L+   TP    
Sbjct: 1906 SSPTTADGSSMPTSTPREGRPPLTS--IPVSTTTVASSEIN---TLSTTLADTRTPVTTY 1960

Query: 529  SRGPSPVSLGNQDTLPVAVALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSN 588
            S+  S  +  +  ++P          AY +G+ P   +   T  +  S  S +       
Sbjct: 1961 SQASSSPTTADGTSMPTP--------AYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDT 2012

Query: 589  PTPA 592
             TPA
Sbjct: 2013 STPA 2016



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 48/191 (25%), Positives = 82/191 (42%), Gaps = 29/191 (15%)

Query: 377  LKVSIGNITLSPA-ISRHSPVQMNRNLSNEELTK--SKPSAPPNEKGTSDLLAWDPLFGP 433
            L VS  + TLS   +   +PV  +   ++    +  S P++ P+E  T       PL   
Sbjct: 3175 LVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMT-------PL--T 3225

Query: 434  SLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTS 493
            S+  S++   +S +S   TTP+   T +     AS    T+   S     P   S P+TS
Sbjct: 3226 SVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTS 3285

Query: 494  NTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQ--DTLPVAVALTE 551
                    P++    +SS +S+ S + A+T T        PV+  +Q   + P+A   + 
Sbjct: 3286 -------MPVSTTTVASSETSTLSTTPADTST--------PVTTYSQASSSPPIADGTSM 3330

Query: 552  SVNAYFKGADP 562
              + Y +G+ P
Sbjct: 3331 PTSTYSEGSTP 3341



 Score = 32.0 bits (71), Expect = 2.4
 Identities = 42/189 (22%), Positives = 78/189 (41%), Gaps = 31/189 (16%)

Query: 380  SIGNITLSPAISRHSPVQMNRNLSNEELTK---SKPSAPPNEKGTSDLLAWDPLFGPSLD 436
            S  +I  +  +  ++P+  +   S+   T    S P++ P+E  T   L   P+   ++ 
Sbjct: 3237 SEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTP--LTSMPVSTTTVA 3294

Query: 437  SSSSSSL-----------TSSSSARPTTPLSVGTIVPPPRPA-----------SRPKLTS 474
            SS +S+L           T+ S A  + P++ GT +P    +           S   + S
Sbjct: 3295 SSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVS 3354

Query: 475  GKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSP 534
             + S ++  P   S PVT++T     A L+   +  +   ++S S   TP   +    +P
Sbjct: 3355 SEASTLSTTPVDTSTPVTTSTE----ASLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTP 3410

Query: 535  VSLGNQDTL 543
            V     +TL
Sbjct: 3411 VVSSEVNTL 3419



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 38/143 (26%), Positives = 60/143 (41%), Gaps = 20/143 (13%)

Query: 438 SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
           +SSS  T  S+  P +  S G+      PAS  K+ S +   +   P   S PVT +   
Sbjct: 194 ASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTIS--- 250

Query: 498 PPAAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALTESVNAYF 557
                   A++SSS +++   S +N+   G   G +P++      +P++V L  S  A  
Sbjct: 251 --------AQASSSPTTAEGPSLSNSAPSG---GSTPLT-----RMPLSVMLVVSSEAST 294

Query: 558 KGADPTKC-IVKITGDMTMSFPS 579
               P    I  IT     S P+
Sbjct: 295 LSTTPAATNIPVITSTEASSSPT 317



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 5/103 (4%)

Query: 432  GPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPV 491
            G +   ++SS  T+   + PT+  S G       P S   + + + S ++  P   + PV
Sbjct: 1427 GTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPV 1486

Query: 492  TSNT----SPPPAAPLARAESSSSISSSASLS-AANTPTVGVS 529
             ++T    SP PA   + A S+ S  S+A  S   +T TV  S
Sbjct: 1487 VTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASS 1529



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 33/133 (24%), Positives = 55/133 (41%), Gaps = 11/133 (8%)

Query: 410  SKPSAPPNEKGTSDLLAWDPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPASR 469
            S P++ P E+ T       PL   ++  S++    S +S   TTP+   T V     AS 
Sbjct: 2681 SMPTSTPGERST-------PL--TNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASS 2731

Query: 470  PKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESSSSISSSASLSAANTPTVGVS 529
               T+   S     P   S P+TS        P+A +E+S+  +++   S   T +   S
Sbjct: 2732 SPTTAEGTSMRISTPSDGSTPLTSIL--VSTLPVASSEASTVSTTAVDTSIPVTTSTEAS 2789

Query: 530  RGPSPVSLGNQDT 542
              P+   + +  T
Sbjct: 2790 SSPTTAEVTSMPT 2802



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 38/153 (24%), Positives = 57/153 (37%), Gaps = 21/153 (13%)

Query: 413  SAPPNEKGTSDLLAW-----DPLFGPSLDSSSSSSLTSSSSARPTTPLSVGTIVPPPRPA 467
            S+P   +GTS  ++       PL G  + ++  +S  S+ S   TTP+   T V     A
Sbjct: 3085 SSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTS--SAISTLSTTPVDTSTPVTTSTEA 3142

Query: 468  SRPKLTSGKLSGINEIPRPFSPPVT--------------SNTSPPPAAPLARAESSSSIS 513
                 TS   S     P   S P+T              S  S  P        +S+  +
Sbjct: 3143 HSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEAT 3202

Query: 514  SSASLSAANTPTVGVSRGPSPVSLGNQDTLPVA 546
            SS +    + PT   S G +P++       PVA
Sbjct: 3203 SSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVA 3235



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 34/165 (20%), Positives = 69/165 (41%), Gaps = 11/165 (6%)

Query: 438  SSSSSLTSSSSARPTTPLSVGTIVPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNT-- 495
            +SSS  T+  ++ PT+  S  +      P +   + S +   ++  P   S PVT++T  
Sbjct: 2788 ASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKA 2847

Query: 496  --SPPPA----APLARAESSSSISSSASLS---AANTPTVGVSRGPSPVSLGNQDTLPVA 546
              SP  A     P++ A   S++ +S  +S    A++    +S  P   S+    +   +
Sbjct: 2848 SSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGS 2907

Query: 547  VALTESVNAYFKGADPTKCIVKITGDMTMSFPSGIIKVFTSNPTP 591
             + T +       + P++    +T  +  + P    +  T + TP
Sbjct: 2908 SSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTP 2952



 Score = 30.4 bits (67), Expect = 6.9
 Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 11/117 (9%)

Query: 439  SSSSLTSSSSARPTTPLSVGTI-VPPPRPASRPKLTSGKLSGINEIPRPFSPPVTSNTSP 497
            ++S+ T S+++ P T  SV T  V P   +SRP   +      + IP  F PP  S+T P
Sbjct: 4022 TTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTITS-----HTIPPTF-PPAHSSTPP 4075

Query: 498  PPAAPLA----RAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAVALT 550
              +A        A ++ +  +  S    + PTV  +  P+  ++ +  T    V  T
Sbjct: 4076 TTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPRT 4132



 Score = 30.0 bits (66), Expect = 9.0
 Identities = 40/167 (23%), Positives = 64/167 (38%), Gaps = 13/167 (7%)

Query: 390  ISRHSPVQMNRNLSNEELTKSKPSAPPN--EKGTSDLLAWDPLFGPSLDSSSSSSLTSSS 447
            +   +PV  +   ++   T    S P +   +GT+ L +       +L ++S  S  S++
Sbjct: 2245 VDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIP--VSHTLVANSEVSTLSTT 2302

Query: 448  SARPTTPLSVGTIV--PPPRPASRPKLTSGKLSGINEIPR-PFSPPV-----TSNTSPPP 499
                 TP +  T    PPP        TS    G   + R P S  +     TS  S  P
Sbjct: 2303 PVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTP 2362

Query: 500  AAPLARAESSSSISSS-ASLSAANTPTVGVSRGPSPVSLGNQDTLPV 545
            A       + S   SS  +    + PT   S G +P++     T+PV
Sbjct: 2363 ADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPV 2409



 Score = 30.0 bits (66), Expect = 9.0
 Identities = 51/214 (23%), Positives = 80/214 (37%), Gaps = 35/214 (16%)

Query: 366  NSHHTMASLDELKVSIGNITLSPAIS---RHSPVQMNR--NLSNEELTKSKPSAPPNEKG 420
            +S  T A +  +  S  + T +P  S    H+PV  +    LS   +  S P     +  
Sbjct: 2789 SSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKAS 2848

Query: 421  TSDLLAWDPLFGPSLDSSSSSSLTS-----------SSSARPTTPLSVGTIVPPPRPASR 469
            +S   A   +   S  S  S+ LTS            +S   TTP+     V      S 
Sbjct: 2849 SSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSS 2908

Query: 470  PKLTSGKLSGINEIPRPFSPPVTSNTSPPPAAPLARAESS----------SSISSSASLS 519
               T+   S     P   S P+TS        P+A +E+S          + +++SA  S
Sbjct: 2909 SPTTAEGTSMPISTPSEVSTPLTSIL--VSTVPVAGSEASTLSTTPVDTRTPVTTSAEAS 2966

Query: 520  AANTPTVGVSRGPS-------PVSLGNQDTLPVA 546
            ++ T   G S   S       P++  +  T+PVA
Sbjct: 2967 SSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVA 3000


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.126    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,977,954
Number of Sequences: 37866
Number of extensions: 1524039
Number of successful extensions: 12650
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 953
Number of HSP's that attempted gapping in prelim test: 9271
Number of HSP's gapped (non-prelim): 3482
length of query: 810
length of database: 18,247,518
effective HSP length: 110
effective length of query: 700
effective length of database: 14,082,258
effective search space: 9857580600
effective search space used: 9857580600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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