Guide to the Human Genome
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Search of human proteins with 225690489

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|225690489 tight junction associated protein 1 isoform a
[Homo sapiens]
         (557 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|225690489 tight junction associated protein 1 isoform a [Homo...  1122   0.0  
gi|225690487 tight junction associated protein 1 isoform a [Homo...  1122   0.0  
gi|225690497 tight junction associated protein 1 isoform b [Homo...  1093   0.0  
gi|225690495 tight junction associated protein 1 isoform b [Homo...  1093   0.0  
gi|225690493 tight junction associated protein 1 isoform b [Homo...  1093   0.0  
gi|225690491 tight junction associated protein 1 isoform b [Homo...  1093   0.0  
gi|227497884 brain-enriched guanylate kinase-associated protein ...   166   5e-41
gi|13124765 brain-enriched guanylate kinase-associated protein [...   166   5e-41
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    52   2e-06
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    50   4e-06
gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]                  50   4e-06
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]         50   4e-06
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       50   5e-06
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    50   7e-06
gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo ...    49   1e-05
gi|216548091 leucine zipper protein 1 [Homo sapiens]                   49   1e-05
gi|216548085 leucine zipper protein 1 [Homo sapiens]                   49   1e-05
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...    49   2e-05
gi|31982906 cingulin-like 1 [Homo sapiens]                             49   2e-05
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    48   2e-05
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...    48   3e-05
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...    48   3e-05
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         48   3e-05
gi|157042792 coiled-coil domain containing 64B [Homo sapiens]          48   3e-05
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    47   4e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    47   4e-05
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    47   5e-05
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    47   5e-05
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    47   5e-05
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    47   5e-05

>gi|225690489 tight junction associated protein 1 isoform a [Homo
           sapiens]
          Length = 557

 Score = 1122 bits (2901), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60
           MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT
Sbjct: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60

Query: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
           RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA
Sbjct: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180
           SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK
Sbjct: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180

Query: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240
           CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE
Sbjct: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240

Query: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300
           SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS
Sbjct: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300

Query: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360
           PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL
Sbjct: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360

Query: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420
           SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD
Sbjct: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420

Query: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480
           RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP
Sbjct: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480

Query: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540
           REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL
Sbjct: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540

Query: 541 HRKDSLTQAQEQGNLLN 557
           HRKDSLTQAQEQGNLLN
Sbjct: 541 HRKDSLTQAQEQGNLLN 557


>gi|225690487 tight junction associated protein 1 isoform a [Homo
           sapiens]
          Length = 557

 Score = 1122 bits (2901), Expect = 0.0
 Identities = 557/557 (100%), Positives = 557/557 (100%)

Query: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60
           MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT
Sbjct: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60

Query: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
           RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA
Sbjct: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180
           SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK
Sbjct: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180

Query: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240
           CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE
Sbjct: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240

Query: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300
           SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS
Sbjct: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300

Query: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360
           PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL
Sbjct: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360

Query: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420
           SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD
Sbjct: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420

Query: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480
           RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP
Sbjct: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480

Query: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540
           REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL
Sbjct: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540

Query: 541 HRKDSLTQAQEQGNLLN 557
           HRKDSLTQAQEQGNLLN
Sbjct: 541 HRKDSLTQAQEQGNLLN 557


>gi|225690497 tight junction associated protein 1 isoform b [Homo
           sapiens]
          Length = 547

 Score = 1093 bits (2827), Expect = 0.0
 Identities = 547/557 (98%), Positives = 547/557 (98%), Gaps = 10/557 (1%)

Query: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60
           MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT
Sbjct: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60

Query: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
           RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL 
Sbjct: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL- 119

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180
                    IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK
Sbjct: 120 ---------IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 170

Query: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240
           CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE
Sbjct: 171 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 230

Query: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300
           SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS
Sbjct: 231 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 290

Query: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360
           PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL
Sbjct: 291 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 350

Query: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420
           SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD
Sbjct: 351 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 410

Query: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480
           RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP
Sbjct: 411 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 470

Query: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540
           REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL
Sbjct: 471 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 530

Query: 541 HRKDSLTQAQEQGNLLN 557
           HRKDSLTQAQEQGNLLN
Sbjct: 531 HRKDSLTQAQEQGNLLN 547


>gi|225690495 tight junction associated protein 1 isoform b [Homo
           sapiens]
          Length = 547

 Score = 1093 bits (2827), Expect = 0.0
 Identities = 547/557 (98%), Positives = 547/557 (98%), Gaps = 10/557 (1%)

Query: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60
           MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT
Sbjct: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60

Query: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
           RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL 
Sbjct: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL- 119

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180
                    IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK
Sbjct: 120 ---------IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 170

Query: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240
           CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE
Sbjct: 171 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 230

Query: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300
           SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS
Sbjct: 231 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 290

Query: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360
           PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL
Sbjct: 291 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 350

Query: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420
           SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD
Sbjct: 351 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 410

Query: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480
           RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP
Sbjct: 411 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 470

Query: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540
           REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL
Sbjct: 471 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 530

Query: 541 HRKDSLTQAQEQGNLLN 557
           HRKDSLTQAQEQGNLLN
Sbjct: 531 HRKDSLTQAQEQGNLLN 547


>gi|225690493 tight junction associated protein 1 isoform b [Homo
           sapiens]
          Length = 547

 Score = 1093 bits (2827), Expect = 0.0
 Identities = 547/557 (98%), Positives = 547/557 (98%), Gaps = 10/557 (1%)

Query: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60
           MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT
Sbjct: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60

Query: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
           RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL 
Sbjct: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL- 119

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180
                    IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK
Sbjct: 120 ---------IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 170

Query: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240
           CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE
Sbjct: 171 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 230

Query: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300
           SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS
Sbjct: 231 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 290

Query: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360
           PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL
Sbjct: 291 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 350

Query: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420
           SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD
Sbjct: 351 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 410

Query: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480
           RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP
Sbjct: 411 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 470

Query: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540
           REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL
Sbjct: 471 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 530

Query: 541 HRKDSLTQAQEQGNLLN 557
           HRKDSLTQAQEQGNLLN
Sbjct: 531 HRKDSLTQAQEQGNLLN 547


>gi|225690491 tight junction associated protein 1 isoform b [Homo
           sapiens]
          Length = 547

 Score = 1093 bits (2827), Expect = 0.0
 Identities = 547/557 (98%), Positives = 547/557 (98%), Gaps = 10/557 (1%)

Query: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60
           MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT
Sbjct: 1   MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASAT 60

Query: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
           RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL 
Sbjct: 61  RRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL- 119

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 180
                    IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK
Sbjct: 120 ---------IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLK 170

Query: 181 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 240
           CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE
Sbjct: 171 CNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPE 230

Query: 241 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 300
           SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS
Sbjct: 231 SLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGS 290

Query: 301 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360
           PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL
Sbjct: 291 PEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISL 350

Query: 361 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 420
           SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD
Sbjct: 351 SLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVD 410

Query: 421 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480
           RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP
Sbjct: 411 RTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 470

Query: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 540
           REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL
Sbjct: 471 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHL 530

Query: 541 HRKDSLTQAQEQGNLLN 557
           HRKDSLTQAQEQGNLLN
Sbjct: 531 HRKDSLTQAQEQGNLLN 547


>gi|227497884 brain-enriched guanylate kinase-associated protein
           [Homo sapiens]
          Length = 593

 Score =  166 bits (420), Expect = 5e-41
 Identities = 106/264 (40%), Positives = 151/264 (57%), Gaps = 27/264 (10%)

Query: 40  ERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQ 99
           E++  LQE+  ELR+RL+  T + E LE E +  +  LE+EL +++EEL+K  +K RR+Q
Sbjct: 2   EKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELEKVTEKLRRIQ 61

Query: 100 NSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTIN 159
           ++Y A QR NQELEDKL+ +           +  E +++ L  EIV L + LL+AK TI+
Sbjct: 62  SNYMALQRINQELEDKLYRMG----------QHYEEEKRALSHEIVALNSHLLEAKVTID 111

Query: 160 KLEELNERYRLDCNLAVQLLKCNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAP 219
           KL E NE YR DCNLA QLL+C++++ R HK ++LP + Q+ V  H+      + P P  
Sbjct: 112 KLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQERVSLHMEK-HGCSLPSPLC 170

Query: 220 SLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPA 279
             A    VPT VIA+VLEKP+   L+S  S ++ R LA          +GV         
Sbjct: 171 HPAYADSVPTCVIAKVLEKPDPASLSSRLSDASARDLA--------FCDGV-------EK 215

Query: 280 PGSPTPQPNGECHSLGTARGSPEE 303
           PG P P   G+ +   TA   PEE
Sbjct: 216 PG-PRPPYKGDIYCSDTALYCPEE 238


>gi|13124765 brain-enriched guanylate kinase-associated protein
           [Homo sapiens]
          Length = 593

 Score =  166 bits (420), Expect = 5e-41
 Identities = 106/264 (40%), Positives = 151/264 (57%), Gaps = 27/264 (10%)

Query: 40  ERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQ 99
           E++  LQE+  ELR+RL+  T + E LE E +  +  LE+EL +++EEL+K  +K RR+Q
Sbjct: 2   EKLSALQEQKGELRKRLSYTTHKLEKLETEFDSTRHYLEIELRRAQEELEKVTEKLRRIQ 61

Query: 100 NSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTIN 159
           ++Y A QR NQELEDKL+ +           +  E +++ L  EIV L + LL+AK TI+
Sbjct: 62  SNYMALQRINQELEDKLYRMG----------QHYEEEKRALSHEIVALNSHLLEAKVTID 111

Query: 160 KLEELNERYRLDCNLAVQLLKCNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPAP 219
           KL E NE YR DCNLA QLL+C++++ R HK ++LP + Q+ V  H+      + P P  
Sbjct: 112 KLSEDNELYRKDCNLAAQLLQCSQTYGRVHKVSELPSDFQERVSLHMEK-HGCSLPSPLC 170

Query: 220 SLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPASPPA 279
             A    VPT VIA+VLEKP+   L+S  S ++ R LA          +GV         
Sbjct: 171 HPAYADSVPTCVIAKVLEKPDPASLSSRLSDASARDLA--------FCDGV-------EK 215

Query: 280 PGSPTPQPNGECHSLGTARGSPEE 303
           PG P P   G+ +   TA   PEE
Sbjct: 216 PG-PRPPYKGDIYCSDTALYCPEE 238


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 83/356 (23%), Positives = 122/356 (34%), Gaps = 51/356 (14%)

Query: 213  ASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPG 272
            ASP  +PS  P +  P S+ A  L+ P S   +   S SA  P      +     +  P 
Sbjct: 681  ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPS 740

Query: 273  DPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRRVI 332
             PASPP   S TP P                  PL A   L   P+P    P+ P  +  
Sbjct: 741  PPASPPMSPSATPPPRVP---------------PLLAAPPLQVPPSPPASLPMSPLAKPP 785

Query: 333  EFSEDKVRIP--RNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQP 390
              +   +  P  +  P P  ++  +   S S     S  A P P      +A        
Sbjct: 786  PQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPS 845

Query: 391  SPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHFAHSP 450
             PA  TL AP    +   D  VS  R  +   P P     R+     + P+L  H + + 
Sbjct: 846  PPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 905

Query: 451  ADRDEV--------VQAPSARPEESELL------------------------LPTEPDSG 478
            +  +E+          A ++ P ++EL                         LP  P +G
Sbjct: 906  STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 965

Query: 479  FPREEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKR 534
             P   + L   I   E  +S  P     + GP    + G+A     +    RSPK+
Sbjct: 966  -PGSADGL-CTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQ 1019



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 90/372 (24%), Positives = 124/372 (33%), Gaps = 60/372 (16%)

Query: 201 MVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDV 260
           M R+   +G E   P PAPS  P    PT    + +              +  RP A   
Sbjct: 176 MARRSRAAGTEVGLPRPAPSARPRP--PTEGPRKSVSSASEHSTTEPSPAARRRPSA--- 230

Query: 261 FVHVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPS 320
                   G    PAS     S TP  +    S  +ARG+P                  +
Sbjct: 231 -------GGGLQRPASRSLSSSATPL-SSPARSGPSARGTPR-----------------A 265

Query: 321 PPHPLYPGRRVIE-FSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTP 379
           P HP  P  + ++     +V  PR    P        +  L+       +ARP P P   
Sbjct: 266 PAHPSQPKPKGLQALRPPQVTPPRKDAAP--ALGPLSSSPLATPSPSGTKARPVPPPDNA 323

Query: 380 ASAQAS--PHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRD 437
           A+   +  P   P   PL L+ P+ SA      L S        TPP  A    T     
Sbjct: 324 ATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPS-----PPATPPSQAPPSMTTPPMQ 378

Query: 438 ALPELQR-------HFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPI 490
           A P LQ        H   SP+     +QAP +    S L   T   S   +      L +
Sbjct: 379 APPSLQTIPPIQVPHSLTSPS-----LQAPPSPLALSSLQATTSLGSPTLQATHSF-LTM 432

Query: 491 SPEEERQSLLPINRGTEEGPGTSHTEG-----RAWPLPSSSRPQRSP--KRMGVHHLHRK 543
           SP + + SL   +R     P +   +       + PL +S  P  SP    + +H L   
Sbjct: 433 SPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQAL 492

Query: 544 DSLTQAQEQGNL 555
            SL     Q  L
Sbjct: 493 SSLASHSPQAPL 504



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 79/323 (24%), Positives = 114/323 (35%), Gaps = 37/323 (11%)

Query: 220 SLAPGAVV--PTSVIARVLEKPESLLLNSAQSGSAG--RPLAEDVFVHVDMSEGVPGDPA 275
           SLAP ++   P S+    LE   SL     Q+ SA    P  E            P  P 
Sbjct: 517 SLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPL 576

Query: 276 SPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEFS 335
           + P P +P+        +       P + LP P    L+P  TP P  P       ++  
Sbjct: 577 TTPPPETPSSIATPPPQAPPALASPPLQGLPSPP---LSPLATPPPQAPPXLALPPLQAP 633

Query: 336 EDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPSPAPL 395
                 P  SPL   +     A+++ L++       PSP    P S  ASP   PS  P 
Sbjct: 634 PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPP-PSPPVQAPFSPPASPPVSPSATPP 692

Query: 396 TLSAPASSASSEEDLLVSWQRAFVDRTPP------PAAVAQRTAFGRDALPELQRHFAHS 449
           + + P+ +A   +          V  +PP      P+A     A    A P LQ      
Sbjct: 693 SQAPPSLAAPPLQ----------VPPSPPASPPMSPSATPPPQAPPPLAAPPLQ----VP 738

Query: 450 PADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISPEEERQSLLPINRGTEEG 509
           P+       +PSA P      L   P    P      +LP+SP  +     P        
Sbjct: 739 PSPPASPPMSPSATPPPRVPPLLAAPPLQVP-PSPPASLPMSPLAKPPPQAP-------- 789

Query: 510 PGTSHTEGRAWPLPSSSRPQRSP 532
           P  +    +A P P +S P ++P
Sbjct: 790 PALATPPLQALPSPPASFPGQAP 812


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 71/256 (27%), Positives = 98/256 (38%), Gaps = 49/256 (19%)

Query: 254 RPLAEDVFVHVDMSEG-VPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEK 312
           R +AE++    +  E  +P  P +PPAP  P P P            SP   L  P    
Sbjct: 384 RAVAEEMMPAAEKEEAKLPPPPLTPPAPSPPPPLP--------PPSTSPPPPLCPPPPPP 435

Query: 313 LNPYPTPSPPHPLYPGRRVIEFSEDKV------RIPRNSPLPNCTYATRQAISLSLVEEG 366
           ++P P PSPP P  P +   E S   V      R     PL     A R+A       EG
Sbjct: 436 VSPPPLPSPPPP--PAQEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAG--PEG 491

Query: 367 SERARPSPVPSTPASAQASPHHQPSPAPLTLS---------APASSASSEEDLLVSWQRA 417
           +  + P+P PST  +    P   P+ AP + +          P  SA S    ++   R 
Sbjct: 492 T--SPPTPTPST--ATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSR--VIKTPRR 545

Query: 418 FVDRTPP-PAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPD 476
           F+D  PP P  V        +  P L+     SP     V Q P+  P  S    PT P 
Sbjct: 546 FMDEDPPKPPKV--------EVSPVLRPPITTSP----PVPQEPA--PVPSPPRAPTPPS 591

Query: 477 SGFPREEEELNLPISP 492
           +  P  E+  ++   P
Sbjct: 592 TPVPLPEKRRSILREP 607



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 57/216 (26%), Positives = 77/216 (35%), Gaps = 41/216 (18%)

Query: 215 PGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDP 274
           P P PS  P A  P S    + EK  S+L              E  F    ++  +P  P
Sbjct: 577 PAPVPS-PPRAPTPPSTPVPLPEKRRSIL-------------REPTFRWTSLTRELPPPP 622

Query: 275 ASPPAPGSPTPQPNGECHS----LGTARGSPEEELPLPAFEK-LNPYPTPSPPHPLYPGR 329
            +PP P +P+P P     S    L  A      E  L  +E  L P P  +P  P     
Sbjct: 623 PAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAP----- 677

Query: 330 RVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQ 389
                 E +     +SP      A  +   LSL        R +PV +TP  A+ SPH  
Sbjct: 678 ------EPEPPPADDSPAEPEPRAVGRTNHLSL-------PRFAPVVTTPVKAEVSPH-- 722

Query: 390 PSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPP 425
              AP   + P + A   + L     +      PPP
Sbjct: 723 --GAPALSNGPQTQAQLLQPLQALQTQLLPQALPPP 756



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 53/235 (22%), Positives = 82/235 (34%), Gaps = 31/235 (13%)

Query: 270 VPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGR 329
           VP  P +P  P +P P P      L       E      +  +  P P P+PP P     
Sbjct: 580 VPSPPRAPTPPSTPVPLPEKRRSILR------EPTFRWTSLTRELPPPPPAPPPP----- 628

Query: 330 RVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVE----EGSERARPSPVPSTPASAQAS 385
                       P  SP P    ++R+ + L   +    E   +   S +   P  A  +
Sbjct: 629 ------------PAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEA 676

Query: 386 PHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRH 445
           P  +P PA  + + P   A    + L   + A V  TP  A V+   A      P+ Q  
Sbjct: 677 PEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQ 736

Query: 446 FAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEEL----NLPISPEEER 496
                      +   +  P + +L  P  P    P E+  +    +LP+S  EE+
Sbjct: 737 LLQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEK 791



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 93/394 (23%), Positives = 132/394 (33%), Gaps = 91/394 (23%)

Query: 213  ASPGPAPSLAPGAV---------VPTSVIARVLEKPESL--------LLNSAQSGSAG-- 253
            ++PG APS  PGA            T   A  +++P           ++ +   G+AG  
Sbjct: 2043 SAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDR 2102

Query: 254  -RP---LAEDVFVHVDMSEGVPGDPASPPAPGSPTPQP---NGECHSLGTARGSPEEE-- 304
             RP   L  ++   V  + G PGD  + P   S  P P   NG   S G    SP +   
Sbjct: 2103 ARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQPSQGLT-ASPADPTR 2161

Query: 305  ----LP-LPAFEKLNPYPTPSPPHPLYP--------GRRVIEFSEDKVRIP---RNSPLP 348
                LP  P    L+  P P PP P           G+  ++ + +   +P   +  PLP
Sbjct: 2162 TFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPPLP 2221

Query: 349  NCTYATRQAISLSLVEEGSERARPSPVPST-PASAQASPHHQPSPAPLTLSAPASSAS-S 406
                      ++S     S    P P+    P      P   P P PLTL   +  AS  
Sbjct: 2222 P---------TISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPP 2272

Query: 407  EEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEE 466
             + + V     F  R+PP     +      D           +  D  +V    S     
Sbjct: 2273 RQAIRVKRVSTFSGRSPPAPPPYKAPRLDED---------GEASEDTPQVPGLGSGGFSR 2323

Query: 467  SELLLPTEP---DSGFPREEEELNLPISPEEERQSLLPINRGTEEGPGT----------- 512
              +  PT     D   P E      P  P +ER  LLP+    E+GP             
Sbjct: 2324 VRMKTPTVRGVLDLDRPGEPAGEESP-GPLQERSPLLPL---PEDGPPQVPDGPPDLLLE 2379

Query: 513  ---SHTEGRA-----WPLPSSSRPQRSPKRMGVH 538
                H  G A      P     +  ++PKR G H
Sbjct: 2380 SQWHHYSGEASSSEEEPPSPDDKENQAPKRTGPH 2413



 Score = 32.7 bits (73), Expect = 0.90
 Identities = 52/224 (23%), Positives = 74/224 (33%), Gaps = 46/224 (20%)

Query: 275 ASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEK----------LNPYPTPSPPHP 324
           A P     PTP P+       TA G P E+ P  A +           + P  +      
Sbjct: 487 AGPEGTSPPTPTPS-------TATGGPPEDSPTVAPKSTTFLKNIRQFIMPVVSARSSRV 539

Query: 325 LYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQA 384
           +   RR ++  ED  + P+    P      R  I+ S            PVP  PA    
Sbjct: 540 IKTPRRFMD--EDPPKPPKVEVSP----VLRPPITTS-----------PPVPQEPAPVP- 581

Query: 385 SPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQR 444
           SP   P+P    +  P    S   +    W     +  PPP A     A      P    
Sbjct: 582 SPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPA--- 638

Query: 445 HFAHSPADRDEVVQAPSARPEESELLL----PTEPDSGFPREEE 484
               + + R  +++AP   P E+ L +     T P  G P   E
Sbjct: 639 ----TSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPE 678



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 40/124 (32%), Positives = 51/124 (41%), Gaps = 25/124 (20%)

Query: 213  ASPGP-APSLAPGAVVPTS-VIARV-LEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEG 269
            ASPGP  P    GA  P   V+A    E+ +SLL   +      +  + D+F   D SE 
Sbjct: 1038 ASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSE- 1096

Query: 270  VPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLN--PYPTPSPPHPLYP 327
                P  PPAP   TP+               E ELPLP  E+ +    PT  P   L  
Sbjct: 1097 ----PGGPPAPRRRTPR---------------ENELPLPEPEEQSRPRKPTLQPVLQLKA 1137

Query: 328  GRRV 331
             RR+
Sbjct: 1138 RRRL 1141


>gi|32698936 B-cell CLL/lymphoma 9-like [Homo sapiens]
          Length = 1499

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 91/363 (25%), Positives = 131/363 (36%), Gaps = 55/363 (15%)

Query: 215  PGPAPSLAPGAV--VPTSVIARVLEKPESLLLNSAQSGSAGR-------------PLAED 259
            P P  S  PG V   P   + R   +P  L ++  Q GS G              PL   
Sbjct: 891  PLPPASNPPGTVHSAPNRGLGR---RPSDLTISINQMGSPGMGHLKSPTLSQVHSPLVTS 947

Query: 260  VFVHVDM----SEGVPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNP 315
               ++      S+ VP   A+PP P   +PQ  G   S+ +  GSP   L  P+    +P
Sbjct: 948  PSANLKSPQTPSQMVPLPSANPPGP-LKSPQVLGSSLSVRSPTGSPSR-LKSPSMAVPSP 1005

Query: 316  YPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYAT------RQAISLSLVEEGSER 369
                SP   + P   V +  +  + +  ++ L N    T      R + S       S  
Sbjct: 1006 GWVASPKTAM-PSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSSSSAPPANPPSGL 1064

Query: 370  ARPS--------PVPS-TPAS---AQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRA 417
              PS        P PS  P S    Q S +  PS  PL  +A  + A+S+++LL    R 
Sbjct: 1065 MNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIATSDDELLP--DRP 1122

Query: 418  FVDRTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAP-SARPEESELLLPTEPD 476
             +   PPP       +  + +   L    A SP   +   Q P S  P  + L  PT   
Sbjct: 1123 LLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPPAMLPSPTPLG 1182

Query: 477  SGFPREEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMG 536
            S         N+P+ P  +     P N       G         P+PSSS+    P R+ 
Sbjct: 1183 S---------NIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMPFPPRLQ 1233

Query: 537  VHH 539
              H
Sbjct: 1234 QPH 1236


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 73/281 (25%), Positives = 101/281 (35%), Gaps = 54/281 (19%)

Query: 274 PASPPAPG-SPTPQPNGECHSLGTARGSPEEELPLPAFEK-LNPYPTP-----SPPHPLY 326
           PA PP    +PTP P     S    R SP      P  ++  +P P P     SPP P  
Sbjct: 563 PAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPP-- 620

Query: 327 PGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASP 386
           P RR       K R+  + P    +    +  S SL  +  + + PS       S Q + 
Sbjct: 621 PKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNK 680

Query: 387 HHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHF 446
            H PSP P    AP +S+S                 PPP          R A    QR  
Sbjct: 681 RHSPSPRP---RAPQTSSS-----------------PPPVR--------RGASSSPQRRQ 712

Query: 447 AHSPADR-----------DEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISPEEE 495
           + SP+ R            ++ +A S  P+    +  +   SG P  E     P +P   
Sbjct: 713 SPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSP--EPAAKKPPAPPSP 770

Query: 496 RQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMG 536
            QS  P    T   P     + ++ P PS S P+ S +  G
Sbjct: 771 VQSQSP---STNWSPAVPVKKAKS-PTPSPSPPRNSDQEGG 807


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 89/339 (26%), Positives = 125/339 (36%), Gaps = 63/339 (18%)

Query: 208 SGQEAASPGPAPSLAPGAVV---PTSVIARVLEKPESLLLNSAQSGSAGRPLAEDV--FV 262
           S +E      A ++A  +V    P +  A ++E P  +   SA+   +   LAE +    
Sbjct: 296 STEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSA 355

Query: 263 HVDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPP 322
               SE  P +   PPA  SP+ +  GE  S  +A+ +P E  PLPA   L   P    P
Sbjct: 356 EESPSEEPPAEILPPPAEKSPSVELLGEIRS-PSAQKAPIEVQPLPAEGALEEAPAKVEP 414

Query: 323 ----------HPLYPGR------------RVIEFSEDKVRIPRNSPLPNCTYATRQAISL 360
                      PL P                +E   ++      SPLP  T A   +  +
Sbjct: 415 PTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKETTAEEASAEI 474

Query: 361 SLVEEGSERARPSPVPSTPASAQ--------ASPHHQPSPAPLTLSAPASSASSEEDLLV 412
            L+      A   P   TPA A+        A   H    +PL     A  AS+E  LL 
Sbjct: 475 QLL-----AATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLA 529

Query: 413 SWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEE-SELLL 471
           + + A  D TP  A         +  L E +     +PA+    VQ+PSA+     E  L
Sbjct: 530 AIE-APADETPAEA---------QSPLSE-ETSAEEAPAE----VQSPSAKGVSIEEAPL 574

Query: 472 PTEPDSGFPREEEELNLPISPEEERQSLLPINRGTEEGP 510
             +P SG     EE +  I      Q L       EE P
Sbjct: 575 ELQPPSGEETTAEEASAAI------QLLAATEASAEEAP 607



 Score = 37.0 bits (84), Expect = 0.048
 Identities = 45/175 (25%), Positives = 59/175 (33%), Gaps = 36/175 (20%)

Query: 362 LVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDR 421
           LVEE + +A P P   T    Q S    P        A A++A +E  + V         
Sbjct: 273 LVEEATAKAEPRPAEETHVQVQPSTEETP-------DAEAATAVAENSVKVQ-------- 317

Query: 422 TPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEES-ELLLPTEPDSGFP 480
            PPPA  A    F               PA+    +Q PSA    S ELL    P S   
Sbjct: 318 -PPPAEEAPLVEF---------------PAE----IQPPSAEESPSVELLAEILPPSAEE 357

Query: 481 REEEELNLPISPEEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRM 535
              EE    I P    +S      G    P          PLP+    + +P ++
Sbjct: 358 SPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKV 412



 Score = 33.1 bits (74), Expect = 0.69
 Identities = 58/240 (24%), Positives = 87/240 (36%), Gaps = 49/240 (20%)

Query: 211 EAASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGV 270
           E  SP    + A  A     ++A + E P       AQS     PL+E+       +E  
Sbjct: 507 EVQSPLAEETTAEEASAEIQLLAAI-EAPADETPAEAQS-----PLSEET-----SAEEA 555

Query: 271 PGDPASPPAPGSPTPQ-------PNGE--------------CHSLGTARGSPEEELPLPA 309
           P +  SP A G    +       P+GE                +  +A  +P E  P PA
Sbjct: 556 PAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPA 615

Query: 310 FE---KLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEG 366
            E   ++ P P    P  + P     E +  +V+ P     P         +     EE 
Sbjct: 616 EEAPAEVQPPPAEEAPAEVQPPPA--EEAPAEVQPPPAEEAP-------AEVQPPPAEEA 666

Query: 367 SERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPA 426
               +P P    PA  Q+ P  + +P   TL+A  S  + +    V  + A VD+  PPA
Sbjct: 667 PAEVQPPPAEEAPAEVQSLPAEE-TPIEETLAAVHSPPADD----VPAEEASVDKHSPPA 721


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 88/341 (25%), Positives = 127/341 (37%), Gaps = 59/341 (17%)

Query: 215 PGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDP 274
           P  +P   P    PTS        PE+  L+         PL E + +   + E     P
Sbjct: 444 PEESPLSPPPEESPTS------PPPEASRLSPPPEELPASPLPEALHLSRPLEES----P 493

Query: 275 ASPP---APGSPTPQPNGECHSLGTARGSPEEELPLPAFEK-LNPYPTPSPPHPLYPGRR 330
            SPP   +P SP P+ +       +    PEE  P PA E  L+P P  SP  P +    
Sbjct: 494 LSPPPEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPF---- 549

Query: 331 VIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARP---SPVPSTPASAQASPH 387
                E+    P    LP  T    +A  LS   E S  + P   SP+   P +++  P 
Sbjct: 550 -----EESPLSPPPEELP--TSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPP 602

Query: 388 HQPSP-------APLTLSAPASSASSE-EDLLVSWQRAFVDRTPPP--AAVAQRTAFGRD 437
            + SP       +PL+    AS  S   ED  +S        +PPP  + ++      R 
Sbjct: 603 FEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRL 662

Query: 438 ALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISPEEERQ 497
           + P  +   +  P +      +P++ P E+  L P   DS      E+      PE+   
Sbjct: 663 SPPPEESPLSPPPEE------SPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLM 716

Query: 498 SLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVH 538
           S LP+    EE P           LP    PQ  P+  G H
Sbjct: 717 S-LPL----EESP----------LLPLPEEPQLCPRSEGPH 742



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 86/339 (25%), Positives = 119/339 (35%), Gaps = 50/339 (14%)

Query: 215 PGPAPSLAPGAVVPTS--------VIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDM 266
           PG  P+  P A+            V +   ++P  L   +   G AG  L   +     +
Sbjct: 377 PGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQL--EAPL 434

Query: 267 SEGVPGDPASPPAPGSPTPQPNGECHSLGTARGSPE-EELPLPAFEKLNPYPTPSPPHPL 325
           +E +P  P    +P SP P+ +        +R SP  EELP     +      P    PL
Sbjct: 435 NEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPL 494

Query: 326 YPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASA--Q 383
            P       S      P +SP     ++  +   LS  EE      PSP   TP S   +
Sbjct: 495 SPPPEESPLSPP----PESSP-----FSPLEESPLSPPEESP----PSPALETPLSPPPE 541

Query: 384 ASPHHQP------SPAPLTL-SAPASSASS----EEDLLVSWQRAFVDRTPPPAAVAQRT 432
           ASP   P      SP P  L ++P   AS      E+  +S        +PPP A     
Sbjct: 542 ASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFP 601

Query: 433 AFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISP 492
            F    L         SP   +    +P + P E+  L P   DS      EE  +   P
Sbjct: 602 PFEESPL---------SPPPEE----SPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPP 648

Query: 493 EEERQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRS 531
           E  R S LP+       P  S         P+S  P+ S
Sbjct: 649 EVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEAS 687



 Score = 42.7 bits (99), Expect = 9e-04
 Identities = 71/273 (26%), Positives = 89/273 (32%), Gaps = 27/273 (9%)

Query: 274 PASPP---APGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRR 330
           P SPP   +P SP P+ +        +R SP      P    L+P P  SP  P     R
Sbjct: 634 PMSPPPEESPMSPPPEVSRLSPLPVVSRLSPP-----PEESPLSPPPEESPTSPPPEASR 688

Query: 331 VIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQAS--PHH 388
           +    ED    P     P         +SL L     E +   P+P  P     S  PH 
Sbjct: 689 LSPPPEDSPTSPPPEDSPASPPPEDSLMSLPL-----EESPLLPLPEEPQLCPRSEGPHL 743

Query: 389 QPSPAPLTLSA----PASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQR 444
            P P    LS     P  S  +EE  L            P        A G    P+ + 
Sbjct: 744 SPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEE 803

Query: 445 HFAHSPADRDEVVQAP-----SARPEESELLLPTEPDSGFPREEEELNLPISPEEERQSL 499
                  +   +   P     S +PEES L   +E     PR EE     +SPE E+  L
Sbjct: 804 LHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEES---HLSPELEKPPL 860

Query: 500 LPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSP 532
            P      E PG           P    P  SP
Sbjct: 861 SPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSP 893



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 94/387 (24%), Positives = 140/387 (36%), Gaps = 66/387 (17%)

Query: 211 EAASPGPAPSLAPGAVVPTSV-IARVLEK------PESLLLNSAQSGSAGRPLAEDVFVH 263
           EA+   P P   P + +P ++ ++R LE+      PE   L+     S   PL E     
Sbjct: 463 EASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSP 522

Query: 264 VDMSEGVPG-----------DPASPP---APGSPTPQ-----PNGECHSLG-----TARG 299
            + S   P             P SPP   +P SP P+     P  E   L      +   
Sbjct: 523 PEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMS 582

Query: 300 SPEEELPL----------PAFEK--LNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRN--- 344
            P EE P+          P FE+  L+P P  SP  P     R+    ED    P     
Sbjct: 583 PPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEES 642

Query: 345 --SPLPNCTYATRQAI--SLSLVEEGSERARP---SPVPSTPASAQASPHHQPSP-APLT 396
             SP P  +  +   +   LS   E S  + P   SP    P +++ SP  + SP +P  
Sbjct: 643 PMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPP 702

Query: 397 LSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEV 456
             +PAS    +  + +  + + +   P    +  R+     +    + H +  P +    
Sbjct: 703 EDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLS 762

Query: 457 VQAP----SARPEESELLLPTEPDSGFPREE--------EELNLPISPEEERQSLLPINR 504
            QA     S +PEE  L    E     P+ E        EEL+L    EE   S +P   
Sbjct: 763 PQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEP 822

Query: 505 GTEEGPGTSHTEGRAWPLPSSSRPQRS 531
                P  SH   ++     S RP+ S
Sbjct: 823 CLSPQPEESHLSPQSEEPCLSPRPEES 849



 Score = 38.5 bits (88), Expect = 0.016
 Identities = 79/309 (25%), Positives = 105/309 (33%), Gaps = 58/309 (18%)

Query: 211 EAASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGV 270
           E +   P P ++   + P  V++R+   PE   L+     S   P  E       +S   
Sbjct: 640 EESPMSPPPEVS--RLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEAS----RLSPPP 693

Query: 271 PGDPASPPAPGSP-TPQPNGECHSLGTARGSPEEE---LPLPAFEKL-----NPYPTPSP 321
              P SPP   SP +P P     SL      P EE   LPLP   +L      P+ +P P
Sbjct: 694 EDSPTSPPPEDSPASPPPEDSLMSL------PLEESPLLPLPEEPQLCPRSEGPHLSPRP 747

Query: 322 PHPLYPGRRVIEFSEDKVRIPRNSPLPN--CTYATRQAISLSLVEEG------------- 366
             P    R        +   P  SP P   C  A  +   LS   EG             
Sbjct: 748 EEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLS 807

Query: 367 --SERARPSPVPSTPA----------SAQA-----SPHHQPSPAPLTLSAPASSASSEED 409
             +E    SPVP  P           S Q+     SP  + S     L  P  S   E+ 
Sbjct: 808 PQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKP 867

Query: 410 LLVSWQRAFVDRTP---PPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEE 466
                Q    +  P   PP   +     G  AL E       SP   +E+  +PS  P  
Sbjct: 868 PEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEP-PLSPLP-EELPLSPSGEPSL 925

Query: 467 SELLLPTEP 475
           S  L+P +P
Sbjct: 926 SPQLMPPDP 934



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 67/269 (24%), Positives = 97/269 (36%), Gaps = 37/269 (13%)

Query: 278  PAPGSPTPQPNGECHSL----GTARGSPEEELPLPAF---EKLNPYPTPSPPHPLYP-GR 329
            P PG P P P G    +       +G      P P     ++   YP    PH L P G 
Sbjct: 2862 PGPGEPVPGPAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGL 2921

Query: 330  RVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQ 389
            R +  S    + P   P P         ++ SL      +    P      +   S    
Sbjct: 2922 RGLAVSGLPPQKPSAPPAPE--------LNNSLHPTPHTKGPTLPTGLELVNRPPSSTEL 2973

Query: 390  PSPAPLTLSA---PASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHF 446
              P PL L A   P      ++D   + +    D       +    A G D L  L+   
Sbjct: 2974 GRPNPLALEAGKLPCEDPELDDD-FDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLE 3032

Query: 447  AHSPADRDEVVQAPSARPEESELLLPTEP--DSGFPRE--EEELNLPISPEE--ERQSLL 500
             + P   D+++       +E +LL  T+P  D+G  ++   E L L  S  E  ER++LL
Sbjct: 3033 TNDP-HLDDLLNG-----DEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALL 3086

Query: 501  PINRGTEEGPGTSHTEGRAWPLPSSSRPQ 529
               RG E  PG    E R  P   +S P+
Sbjct: 3087 ---RGVE--PGPLGPEERPPPAADASEPR 3110


>gi|7662228 synaptosomal-associated protein, 91kDa homolog [Homo
           sapiens]
          Length = 907

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 91/405 (22%), Positives = 139/405 (34%), Gaps = 87/405 (21%)

Query: 212 AASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVP 271
           A +P PAP++A  A   T+  A       +    SA + +   P A D+F   D+ E  P
Sbjct: 520 ATAPSPAPAVAAAAAATTAATAAAT----TTTTTSAATATTAPP-ALDIFG--DLFESTP 572

Query: 272 GDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFE------KLNPYPTPSPPHPL 325
              A+P     P   P+ +  S       P+   P+P          ++ +  PSP    
Sbjct: 573 EVAAAP----KPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFAAPSPATTA 628

Query: 326 YPGR----RVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEE-GSERARPSPVPSTPA 380
            P +     VI+   D      + P P    A+  + S  L+   G     PSP P TPA
Sbjct: 629 SPAKVDSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLLAGFGGSFMAPSPSPVTPA 688

Query: 381 SAQASPHHQPSPAPLTLSAPASSASSEEDLLV--------------SWQRAFVDRTPPPA 426
                   QP+      + P++S+SS  D  V              + Q A V   PP  
Sbjct: 689 QNNLL---QPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPAGQPAPVSMVPPSP 745

Query: 427 AVAQRTAFGRD---ALPELQRHFAHS---------------------------------- 449
           A+A   A G D   +L  L  +   S                                  
Sbjct: 746 AMAASKALGSDLDSSLASLVGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKVAPATWS 805

Query: 450 -----PADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISPEEERQSLLPINR 504
                 A     V   S+ P  +      +P +GF        +P+ P++      P+ R
Sbjct: 806 AGVPPSAPLQGAVPPTSSVPPVAGAPSVGQPGAGFGMPPAGTGMPMMPQQPVMFAQPMMR 865

Query: 505 ---GTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHLHRKDSL 546
              G    PGT  +     P P+S  P++ P +  +  L+ KD L
Sbjct: 866 PPFGAAAVPGTQLSPS---PTPASQSPKKPPAKDPLADLNIKDFL 907



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 71/299 (23%), Positives = 104/299 (34%), Gaps = 38/299 (12%)

Query: 212 AASPGPAPSLAPGAVVPTSV--IARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEG 269
           AASPG AP+ + GA  P +   +A  L+        +   GSA      D+F        
Sbjct: 445 AASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAAPELDLFAMKPPETS 504

Query: 270 VPG-DPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPG 328
           VP   P +  AP  P   P+        A  +             +     + P  L   
Sbjct: 505 VPVVTPTASTAPPVPATAPSPAPAVAAAAAATTAATAAATTTTTTSAATATTAPPALDIF 564

Query: 329 RRVIEFSEDKVRIPRNSPLPNCTYATRQAIS-----LSLVEEGSERAR-------PSPVP 376
             + E + +    P+    P+    +  A S      S V E S  A         +P P
Sbjct: 565 GDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLSVDAFAAPSP 624

Query: 377 STPAS---------------AQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDR 421
           +T AS               A  S   +P PA    S  ASS+S+  DLL  +  +F+  
Sbjct: 625 ATTASPAKVDSSGVIDLFGDAFGSSASEPQPA----SQAASSSSASADLLAGFGGSFMAP 680

Query: 422 TPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFP 480
           +P P   AQ         P  +  F  +P+        PS      +LL+PT   +G P
Sbjct: 681 SPSPVTPAQNNLL----QPNFEAAFGTTPSTSSSSSFDPSVFDGLGDLLMPTMAPAGQP 735


>gi|216548091 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 21/151 (13%)

Query: 19  RELRLEIPGSRLEQEEPLTDAERMKLLQEEN---------EELRRRLASATRRTEALERE 69
           R LR+E     +++ E L    + KL +EEN         E L++R+A   +  EA  R 
Sbjct: 71  RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRS 130

Query: 70  LEIGQDCLELELGQSRE---------ELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
                DC +L L  + E         EL+  + K + L++S     +T Q L  +L  L 
Sbjct: 131 ---KNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK 187

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKL 151
           SL+ S++   K      K  +  I ELT KL
Sbjct: 188 SLTLSFVSERKYLNEKEKENEKLIKELTQKL 218


>gi|216548085 leucine zipper protein 1 [Homo sapiens]
          Length = 1076

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 44/151 (29%), Positives = 67/151 (44%), Gaps = 21/151 (13%)

Query: 19  RELRLEIPGSRLEQEEPLTDAERMKLLQEEN---------EELRRRLASATRRTEALERE 69
           R LR+E     +++ E L    + KL +EEN         E L++R+A   +  EA  R 
Sbjct: 71  RVLRIEGKDEEIKRAEDLCRLMKEKLEEEENLTRELKSEIERLQKRMAELEKLEEAFSRS 130

Query: 70  LEIGQDCLELELGQSRE---------ELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
                DC +L L  + E         EL+  + K + L++S     +T Q L  +L  L 
Sbjct: 131 ---KNDCTQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLDKTEQSLASELEKLK 187

Query: 121 SLSHSWIFAIKKAEMDRKTLDWEIVELTNKL 151
           SL+ S++   K      K  +  I ELT KL
Sbjct: 188 SLTLSFVSERKYLNEKEKENEKLIKELTQKL 218


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
            sapiens]
          Length = 1386

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 82/303 (27%), Positives = 110/303 (36%), Gaps = 62/303 (20%)

Query: 274  PASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAF-EKLNPYPTPSPPHPLYPGRRVI 332
            P  P       P  +G C    + R +P    P P++ ++     TPSPP P  P   + 
Sbjct: 1115 PPMPERSHLTEPSSSGGCLVTPSRRETPS---PTPSYGQQSTATLTPSPPDPPQPPTDMP 1171

Query: 333  EFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPSP 392
               +   R+P     P         +S+S    G   ARP+ + + PA   ASPH  PSP
Sbjct: 1172 HLHQMPRRVPLGPSSP---------LSVSQPMLGIREARPAGLGAGPA---ASPHLSPSP 1219

Query: 393  APLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHFAHSPAD 452
            AP T    ASSA        +WQ    + TPP      R      ALP  +    +SP D
Sbjct: 1220 APST----ASSAPGR-----TWQ-GNGEMTPPLQGPRARFRKKPKALPYRRE---NSPGD 1266

Query: 453  RDEVVQAPSARPEESELLLPTE------------PDSGFPREEEELNLP----ISPEEE- 495
                +  P   P E E     E              SG  +  + + L     + P+EE 
Sbjct: 1267 ----LPPPPLPPPEEEASWALELRAAGSMSSLERERSGERKAVQAVPLAAQRVLHPDEEA 1322

Query: 496  -----RQSLLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHLHRKDSLTQAQ 550
                 R S L   +GT           R     SSSR  R P R       R  S +Q+Q
Sbjct: 1323 WLPYSRPSFLSRGQGTSTCSTAGSNSSRG---SSSSRGSRGPGR----SRSRSQSRSQSQ 1375

Query: 551  EQG 553
              G
Sbjct: 1376 RPG 1378


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 36/140 (25%), Positives = 74/140 (52%), Gaps = 7/140 (5%)

Query: 31  EQEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDK 90
           EQ++  T+  R+KLLQEENE+L+ R     RR   L+R++E     L+ +  +++E L K
Sbjct: 814 EQDQAGTEM-RVKLLQEENEKLQGRSEELERRVAQLQRQIE----DLKGDEAKAKETLKK 868

Query: 91  FKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNK 150
           ++ + R+L+ +   +++  +E       L +   +    + +   ++K L  ++ E + +
Sbjct: 869 YEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQ 928

Query: 151 LLDAKNTINKLEELNERYRL 170
               +   N++E  NER+ L
Sbjct: 929 KEQLRRLKNEME--NERWHL 946



 Score = 32.3 bits (72), Expect = 1.2
 Identities = 35/150 (23%), Positives = 65/150 (43%), Gaps = 13/150 (8%)

Query: 38  DAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRR 97
           D + + + +EE E+L R+           EREL   +  L+ E+    +E+DK K+++  
Sbjct: 738 DLQDLLIAKEEQEDLLRKR----------ERELTALKGALKEEVSSHDQEMDKLKEQY-- 785

Query: 98  LQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNT 157
                 A + + +E    +  LAS S++        EM  K L  E  +L  +  + +  
Sbjct: 786 -DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERR 844

Query: 158 INKLEELNERYRLDCNLAVQLLKCNKSHFR 187
           + +L+   E  + D   A + LK  +   R
Sbjct: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIR 874



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 23/97 (23%), Positives = 43/97 (44%), Gaps = 8/97 (8%)

Query: 31   EQEEPLTDAERMKL-LQEENEELRRRLASATRRTEALERELEIGQDCLELELG------- 82
            E E+ L   ER +  LQ  N  L R++     + +     L   +D L L L        
Sbjct: 1157 ELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVE 1216

Query: 83   QSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTL 119
            ++ EE+D+ +   ++LQ         N+ L+ +L+++
Sbjct: 1217 EAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSM 1253



 Score = 29.3 bits (64), Expect = 9.9
 Identities = 42/143 (29%), Positives = 65/143 (45%), Gaps = 28/143 (19%)

Query: 19  RELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLE 78
           R+L+LE+   +  +EE     ERM+      EELR +          L++ LE      E
Sbjct: 628 RQLQLEVKNQQNIKEE----RERMR---ANLEELRSQHNEKVEENSTLQQRLEES----E 676

Query: 79  LELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRK 138
            EL ++ EEL  F+ K  R Q+     Q   ++L+D+L    S  H  + + K++E    
Sbjct: 677 GELRKNLEEL--FQVKMEREQH-----QTEIRDLQDQL----SEMHDELDSAKRSE---- 721

Query: 139 TLDWEIVELTNKLLDAKNTINKL 161
             D E   L  +LL AK  +  L
Sbjct: 722 --DREKGALIEELLQAKQDLQDL 742



 Score = 29.3 bits (64), Expect = 9.9
 Identities = 33/153 (21%), Positives = 66/153 (43%), Gaps = 7/153 (4%)

Query: 17   EHRELRLEIPGSRLEQEEPLTDA----ERMKLLQEENEELRRRLASATRRTEALERELEI 72
            E  E++ ++    LE E+    A    + M+L++EE  + +R    A  + + LE+ L+ 
Sbjct: 985  ELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKD 1044

Query: 73   GQDCLELE--LGQSREELDK-FKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFA 129
             +  LE +  L   R  L K  +DK  +L+      +  +  L +++             
Sbjct: 1045 LEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNE 1104

Query: 130  IKKAEMDRKTLDWEIVELTNKLLDAKNTINKLE 162
            + +    R+ L+ + + L  +  D K+ I  LE
Sbjct: 1105 LLQERAARQDLECDKISLERQNKDLKSRIIHLE 1137


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 65/247 (26%), Positives = 86/247 (34%), Gaps = 59/247 (23%)

Query: 203 RKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPESLLL-NSAQSGSAGRPLAEDVF 261
           ++ +  G+    PG   S AP   +P   I+  L  P S  L N++++  A R       
Sbjct: 114 QRDVAGGKTGQGPG---SRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPP--- 167

Query: 262 VHVDMSEGVPGDPA-SPPAPGSPTPQPNGECHSLGTARGSPEEEL----------PLPAF 310
                   VP  P  +PP P  P P P      + T   SP   L          P+P  
Sbjct: 168 -----RPNVPAPPPPTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPC- 221

Query: 311 EKLNPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSP------------LPNCTYATRQAI 358
               P P P PP P  P         DK   P+ +P            LP C Y   +A 
Sbjct: 222 ---APPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAE 278

Query: 359 SLSLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAF 418
             S  ++  E   P+P P  P  A  SP       PL    P  ++SSE           
Sbjct: 279 PASPAQDAQE--PPAPPPPLPPYASCSPRASLPAPPL----PGVNSSSE----------- 321

Query: 419 VDRTPPP 425
              TPPP
Sbjct: 322 ---TPPP 325



 Score = 36.6 bits (83), Expect = 0.062
 Identities = 83/381 (21%), Positives = 118/381 (30%), Gaps = 94/381 (24%)

Query: 214 SPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLA---EDVFVHVDMSEGV 270
           +P P P  AP     TS + R   K  S LL   Q G+  R +    +     ++ S+G 
Sbjct: 20  APPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSAPQIESSKGT 79

Query: 271 PGD---------PASPP------APGSPTPQPNGECHSLGTARG------SPEEELP--- 306
             +          ++PP      A G P  +P G+    G   G      +P   LP   
Sbjct: 80  NKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKT 139

Query: 307 ------LPAFEKLN---------------------PYPTPSPPHPLYPGRRVIEFSEDKV 339
                  PA  +L                      P PTP PP P  P            
Sbjct: 140 ISGPLIPPASPRLGNTSEAHGAARTAPPRPNVPAPPPPTPPPPPPPLP-----------P 188

Query: 340 RIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSA 399
            +P +SP+     +    ++     +G+      PVP  P      P   P P P     
Sbjct: 189 PLPSSSPIKTPLVSPPGPLT-----KGNLPVVAPPVPCAP------PPPPPPPPPTPPPL 237

Query: 400 PASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDEVVQA 459
           P +S  S++ +        +   PPP  +     +     P L+   A    D  E    
Sbjct: 238 PPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGY-----PGLKAEPASPAQDAQEPPAP 292

Query: 460 PSARPE----ESELLLPTEPDSGFPREEEELNLPISPEEERQSLLPINRGTEEGPGTSHT 515
           P   P          LP  P  G      E   P+ P+       P   G +  P     
Sbjct: 293 PPPLPPYASCSPRASLPAPPLPGV-NSSSETPPPLPPKSPSFQAPPQKAGAQALP----- 346

Query: 516 EGRAWPLPSSSRPQRSPKRMG 536
              A P P  S+P    KR G
Sbjct: 347 ---APPAPPGSQPFLQKKRHG 364


>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 69/282 (24%), Positives = 96/282 (34%), Gaps = 33/282 (11%)

Query: 267 SEGVPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLY 326
           S  VPG P  P    +P P P     +LG   G    + PL +    +P+    PP P  
Sbjct: 203 SPPVPGGPRQPSPGPTPPPFPGNRGTALG---GGSIRQSPLSSS---SPFSN-RPPLPPT 255

Query: 327 PGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTP---ASAQ 383
           P R +    +DK       P P      R +I    V     +    PVPSTP   AS+Q
Sbjct: 256 PSRAL----DDK------PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQ 305

Query: 384 ASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQ 443
           A P   P   P     P SS+ ++E   +  +   +  + PP     R+        E  
Sbjct: 306 APPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERP 365

Query: 444 RHFAHSPADRDEVVQAPS--ARPEESELLLPTEPD----SGFPREEEELNLPISPEEERQ 497
                 P  R   +  P   +R   +   LP  P     SG          P+ P+    
Sbjct: 366 PPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSA 425

Query: 498 SLLP-------INRGTEEGPGTSHTEGRAWPLPSSSRPQRSP 532
              P       I  G ++ P     E R +  P S  P   P
Sbjct: 426 GAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEP 467



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 54/197 (27%), Positives = 69/197 (35%), Gaps = 45/197 (22%)

Query: 372 PSPVPSTPASAQASPHH-----------QPSPAPLTLSAP-------------------A 401
           P PVPSTP   Q+SPH+           QPSP P     P                   +
Sbjct: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSS 243

Query: 402 SSASSEEDLLVSWQRAFVDR-TPPPAAVAQRTAFGRDAL----PELQRHFAHSPADRDEV 456
           S  S+   L  +  RA  D+  PPP  V  R +  R+A+    P+  +    S       
Sbjct: 244 SPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSAS 303

Query: 457 VQAPSARPEESELLLPTEPDSGFPREE----EELNLPIS------PEEERQSLLPINRGT 506
            QAP   P  S    P  P S    +E     + NL +S      P   R   LP     
Sbjct: 304 SQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSE 363

Query: 507 EEGPGTSHTEGRAWPLP 523
              P      GR+ PLP
Sbjct: 364 RPPPPVRDPPGRSGPLP 380



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 60/227 (26%), Positives = 75/227 (33%), Gaps = 53/227 (23%)

Query: 268 EGVPGDPAS---PPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLN---------- 314
           E VP  P     PP P +P P  + +          P    PLP     N          
Sbjct: 280 EAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPP-PLPPSSSGNDETPRLPQRN 338

Query: 315 --------PYPTPSPPHPLYPGRRVIEFSEDKVRIP--RNSPLP------------NCTY 352
                   P P+P    PL P     E     VR P  R+ PLP                
Sbjct: 339 LSLSSSTPPLPSPGRSGPLPPPPS--ERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALP 396

Query: 353 ATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLV 412
           AT Q  S S V+      RP P+P    SA A     P P P T        S  ED   
Sbjct: 397 ATPQLPSRSGVDSPRSGPRP-PLPPDRPSAGA----PPPPPPSTSIRNGFQDSPCED--- 448

Query: 413 SWQRAF----VDRTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDE 455
            W+  F    +   PPP    Q T   +    +L R+ + S ++R E
Sbjct: 449 EWESRFYFHPISDLPPPEPYVQTT---KSYPSKLARNESRSGSNRRE 492


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 69/282 (24%), Positives = 96/282 (34%), Gaps = 33/282 (11%)

Query: 267 SEGVPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLY 326
           S  VPG P  P    +P P P     +LG   G    + PL +    +P+    PP P  
Sbjct: 203 SPPVPGGPRQPSPGPTPPPFPGNRGTALG---GGSIRQSPLSSS---SPFSN-RPPLPPT 255

Query: 327 PGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTP---ASAQ 383
           P R +    +DK       P P      R +I    V     +    PVPSTP   AS+Q
Sbjct: 256 PSRAL----DDK------PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQ 305

Query: 384 ASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQ 443
           A P   P   P     P SS+ ++E   +  +   +  + PP     R+        E  
Sbjct: 306 APPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERP 365

Query: 444 RHFAHSPADRDEVVQAPS--ARPEESELLLPTEPD----SGFPREEEELNLPISPEEERQ 497
                 P  R   +  P   +R   +   LP  P     SG          P+ P+    
Sbjct: 366 PPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSA 425

Query: 498 SLLP-------INRGTEEGPGTSHTEGRAWPLPSSSRPQRSP 532
              P       I  G ++ P     E R +  P S  P   P
Sbjct: 426 GAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEP 467



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 54/197 (27%), Positives = 69/197 (35%), Gaps = 45/197 (22%)

Query: 372 PSPVPSTPASAQASPHH-----------QPSPAPLTLSAP-------------------A 401
           P PVPSTP   Q+SPH+           QPSP P     P                   +
Sbjct: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSS 243

Query: 402 SSASSEEDLLVSWQRAFVDR-TPPPAAVAQRTAFGRDAL----PELQRHFAHSPADRDEV 456
           S  S+   L  +  RA  D+  PPP  V  R +  R+A+    P+  +    S       
Sbjct: 244 SPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSAS 303

Query: 457 VQAPSARPEESELLLPTEPDSGFPREE----EELNLPIS------PEEERQSLLPINRGT 506
            QAP   P  S    P  P S    +E     + NL +S      P   R   LP     
Sbjct: 304 SQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSE 363

Query: 507 EEGPGTSHTEGRAWPLP 523
              P      GR+ PLP
Sbjct: 364 RPPPPVRDPPGRSGPLP 380



 Score = 30.8 bits (68), Expect = 3.4
 Identities = 60/227 (26%), Positives = 75/227 (33%), Gaps = 53/227 (23%)

Query: 268 EGVPGDPAS---PPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLN---------- 314
           E VP  P     PP P +P P  + +          P    PLP     N          
Sbjct: 280 EAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPP-PLPPSSSGNDETPRLPQRN 338

Query: 315 --------PYPTPSPPHPLYPGRRVIEFSEDKVRIP--RNSPLP------------NCTY 352
                   P P+P    PL P     E     VR P  R+ PLP                
Sbjct: 339 LSLSSSTPPLPSPGRSGPLPPPPS--ERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALP 396

Query: 353 ATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLV 412
           AT Q  S S V+      RP P+P    SA A     P P P T        S  ED   
Sbjct: 397 ATPQLPSRSGVDSPRSGPRP-PLPPDRPSAGA----PPPPPPSTSIRNGFQDSPCED--- 448

Query: 413 SWQRAF----VDRTPPPAAVAQRTAFGRDALPELQRHFAHSPADRDE 455
            W+  F    +   PPP    Q T   +    +L R+ + S ++R E
Sbjct: 449 EWESRFYFHPISDLPPPEPYVQTT---KSYPSKLARNESRSGSNRRE 492


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 81/338 (23%), Positives = 114/338 (33%), Gaps = 67/338 (19%)

Query: 212  AASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVP 271
            A+SP P P+ +P A   +S ++  L     + + +     A  PL   +   + +S   P
Sbjct: 1411 ASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGP 1470

Query: 272  G---------DPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPP 322
                       P  P APG P+  P+G   S           L L     L+   TP   
Sbjct: 1471 ALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALT------LGLATAPSLSSSQTPG-- 1522

Query: 323  HPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASA 382
            HPL             +  P +S +P        A S  LV      A  SP PS P   
Sbjct: 1523 HPL-------------LLAPTSSHVPGLNSTVAPACSPVLVPAS---ALASPFPSAP--- 1563

Query: 383  QASPHHQPSPAPLTLSAPASSASSEEDL----LVSWQRAFVDRTP-PPAAVAQRTAFGRD 437
                   P+PA  +L APASSAS         + + Q A +  +P PP A     A    
Sbjct: 1564 ------NPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPG 1617

Query: 438  ALPELQRH------FAHSPADRDEVVQA-------PSARPEESELLLPTEPDSGFPREEE 484
            A P L          A S      +  A       P   P  ++ +LP    S  P    
Sbjct: 1618 AAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPAS 1677

Query: 485  ELNLPISPE-------EERQSLLPINRGTEEGPGTSHT 515
               L ++P              L +  G  +GP  + T
Sbjct: 1678 TQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQT 1715



 Score = 31.6 bits (70), Expect = 2.0
 Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 10/83 (12%)

Query: 214  SPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVP-- 271
            SP P P+L P A    ++     + P S   +   S S   PL   +   + +S+  P  
Sbjct: 1791 SPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDT 1850

Query: 272  ----GDPASPPAP----GSPTPQ 286
                  P SPP+     G P P+
Sbjct: 1851 LTLRSGPPSPPSTATSFGGPRPR 1873



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 52/197 (26%), Positives = 73/197 (37%), Gaps = 52/197 (26%)

Query: 211  EAASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGV 270
            +A +P P P+  P +V+P+S  +     P  L L  A +      +     V + + +  
Sbjct: 1261 QAVAPTPGPT--PVSVLPSSTPSTT-PAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQA- 1316

Query: 271  PGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRR 330
            P D  +P  P +P P+P             P   LP      LNP PT      L PGR 
Sbjct: 1317 PRDGLTPVPPLAPAPRP-------------PSSGLPAV----LNPRPT------LTPGR- 1352

Query: 331  VIEFSEDKVRIPRNSPLPNCTYATRQA-ISLSLVEEGSERARPSPVPSTPASAQASPHHQ 389
                            LP  T  T +A +    +     +   SP P   ASA       
Sbjct: 1353 ----------------LPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASA------- 1389

Query: 390  PSPAPLTLSAPASSASS 406
            P  APLT+S+P    SS
Sbjct: 1390 PGAAPLTISSPLHVPSS 1406



 Score = 29.3 bits (64), Expect = 9.9
 Identities = 52/182 (28%), Positives = 74/182 (40%), Gaps = 27/182 (14%)

Query: 324  PLYPGRRVIEF---SEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERA-RPSPVPS-T 378
            P  PG RV E    +  + +   ++P+ +  + TR   +        ER  RP+P P  T
Sbjct: 2388 PERPGTRVSERLRGARAETQGANHTPVISA-HQTRSTTTPPRCSPARERVPRPAPRPRPT 2446

Query: 379  PASAQAS-PHHQPSP--APLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFG 435
            PASA A+ P   P P  AP+ +SAP         +L S         PPP+ +   ++  
Sbjct: 2447 PASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPS--------PPPPSQIPPCSSPA 2498

Query: 436  RDALPELQRHFAHSPADRDEVVQAPSARPEESELLL--PTEPDSGFPREEEELNLPISPE 493
                P      AH+P      +  PS     S LLL  P+ P S        L L + PE
Sbjct: 2499 CTPPPACTPPPAHTPPPAQTCLVTPS-----SPLLLGPPSVPISA---SVTNLPLGLRPE 2550

Query: 494  EE 495
             E
Sbjct: 2551 AE 2552


>gi|157042792 coiled-coil domain containing 64B [Homo sapiens]
          Length = 508

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 40/139 (28%), Positives = 61/139 (43%), Gaps = 11/139 (7%)

Query: 40  ERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREE-----------L 88
           ER + LQ+EN ELRR LA+     EA   ELE   + L  +LG+ R E           L
Sbjct: 91  EREERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARAL 150

Query: 89  DKFKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELT 148
            +  ++  RL      + +T QEL+ +L  L     +   A  +     ++L  E   L 
Sbjct: 151 SELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQ 210

Query: 149 NKLLDAKNTINKLEELNER 167
           ++  D +  I  L E  E+
Sbjct: 211 SRRQDLEAQIRGLREEVEK 229



 Score = 32.0 bits (71), Expect = 1.5
 Identities = 26/82 (31%), Positives = 41/82 (50%), Gaps = 10/82 (12%)

Query: 12  RKAPPEHRELRL-EIPGSRL-----EQEEPLTDAERMKL----LQEENEELRRRLASATR 61
           R+     +ELR  E PG  L     +++E +  A  + L    +  E + L R L  A R
Sbjct: 381 REELQRQKELRAQEDPGEALHSALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIR 440

Query: 62  RTEALERELEIGQDCLELELGQ 83
           +  AL +ELE  QD +++ +GQ
Sbjct: 441 QKVALTQELEAWQDDMQVVIGQ 462



 Score = 31.2 bits (69), Expect = 2.6
 Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 22/131 (16%)

Query: 13  KAPPEHRELRLEIPGSRLE-QEEPLTDAE---RMKLLQEENEELRRRLASATRRTEALER 68
           +A    +EL+ E+   R + Q + L  AE   R++ LQ EN+ L+ R      +   L  
Sbjct: 166 QASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLRE 225

Query: 69  ELEIGQDCLE-----------------LELGQSREELDKFKDKFRRLQNSYTASQRTNQE 111
           E+E G+  L+                 LEL ++R E  +     RRLQ   +  +  ++ 
Sbjct: 226 EVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESR- 284

Query: 112 LEDKLHTLASL 122
           L+D   + ASL
Sbjct: 285 LQDADVSAASL 295


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 82/336 (24%), Positives = 123/336 (36%), Gaps = 55/336 (16%)

Query: 213 ASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPG 272
           ASP  +PS  P +  P S+ A  L+ P S   +   S SA  P      +     +    
Sbjct: 456 ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 515

Query: 273 DPASPPAPGSPTPQ--PNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRR 330
            P +PPA  +P  Q  P+      G A  SP   LP      ++P  TP P  P      
Sbjct: 516 PPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP------MSPLATPPPQAPPVLAAP 569

Query: 331 VIEF-----SEDKVRIPRNSPLPN-CTYATRQAISLSLVEEGSERARPSPVPSTPASAQA 384
           +++      +   ++ PR  P P   T  +   ++L+L         P P   +P+S  +
Sbjct: 570 LLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP-----GPPPPPSRSPSSTLS 624

Query: 385 SPHHQPSPAPLTLSAPASSASSEEDLLVSWQ---RAFVDRTPPP---AAVAQRTAFGRDA 438
            P          L+  +SSA+S  + L  +          +PPP    A     A+ R  
Sbjct: 625 GP---------DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP 675

Query: 439 LPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISPEEERQS 498
            P L   F  +P        AP          LP  P +G P   + L   I   E  +S
Sbjct: 676 APPLA--FRGAPG-------AP----------LPWPPATG-PGSADGL-CTIYETEGPES 714

Query: 499 LLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKR 534
             P     + GP    + G+A     +    RSPK+
Sbjct: 715 ATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQ 750



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 76/307 (24%), Positives = 106/307 (34%), Gaps = 55/307 (17%)

Query: 201 MVRKHLHSGQEAASPGPAPSLAP--------GAVVPTSVIARVLEKPESLLLNSAQSG-- 250
           M R+   +G E   P PAPS  P         +V   S  +     P +    SA  G  
Sbjct: 176 MARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQ 235

Query: 251 -SAGRPLAEDVFVHVDMSEGVPGDPASPPAPGSPT-PQPNGECHSLGTARGSPEEELPLP 308
             A R L+         +   P    +P AP  P+ P+P G   +L   + +P  +   P
Sbjct: 236 RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKG-LQALRPPQVTPPRKDAAP 294

Query: 309 AFEKL--NPYPTPSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEG 366
           A   L  +P  TPSP   L                   S  P    AT  + SL+     
Sbjct: 295 ALGPLSSSPLATPSPSAAL------------------QSQAPPTLPATPHSSSLTC---- 332

Query: 367 SERARPSPVPSTPASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTP-PP 425
                 +P+P  P S  A P  Q  P+P   + P+ + +S     +    +F+   P  P
Sbjct: 333 ---QLATPLPLAPPSPSAPPSLQTLPSP-PATPPSQATTSLGSPTLQATHSFLPSPPLSP 388

Query: 426 AAVAQRTAFGRDALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEE 485
            A     A    ALP LQ               +P A P  S L  P+ P +        
Sbjct: 389 LATPPPQAPPALALPPLQ------------APPSPPASPPLSPLATPS-PQAPNALAVHL 435

Query: 486 LNLPISP 492
           L  P SP
Sbjct: 436 LQAPFSP 442



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 59/230 (25%), Positives = 86/230 (37%), Gaps = 32/230 (13%)

Query: 214 SPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGD 273
           SPGP  S  PG    T+    + +K   L +++ ++ + G+  A +      +S G   D
Sbjct: 110 SPGPVSS--PGRASGTTRPGPLGQK--GLRISAEETVARGK--ATEAPKRSALSAGARRD 163

Query: 274 PASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIE 333
             S P PG+P+P       + GT  G     LP PA     P   P PP    P + V  
Sbjct: 164 -TSGPTPGTPSPAMARRSRAAGTEVG-----LPRPA-----PSARPRPPTE-GPRKSVSS 211

Query: 334 FSEDKVRIPRNSP--LPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPS 391
            SE     P  +    P+     ++  S SL    +  + P+    +      +P H   
Sbjct: 212 ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 271

Query: 392 PAPLTLSA--------PASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTA 433
           P P  L A        P   A+     L S   A    TP P+A  Q  A
Sbjct: 272 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA----TPSPSAALQSQA 317


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 82/336 (24%), Positives = 123/336 (36%), Gaps = 55/336 (16%)

Query: 213 ASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPG 272
           ASP  +PS  P +  P S+ A  L+ P S   +   S SA  P      +     +    
Sbjct: 417 ASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476

Query: 273 DPASPPAPGSPTPQ--PNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRR 330
            P +PPA  +P  Q  P+      G A  SP   LP      ++P  TP P  P      
Sbjct: 477 PPQAPPALATPPLQALPSPPASFPGQAPFSPSASLP------MSPLATPPPQAPPVLAAP 530

Query: 331 VIEF-----SEDKVRIPRNSPLPN-CTYATRQAISLSLVEEGSERARPSPVPSTPASAQA 384
           +++      +   ++ PR  P P   T  +   ++L+L         P P   +P+S  +
Sbjct: 531 LLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP-----GPPPPPSRSPSSTLS 585

Query: 385 SPHHQPSPAPLTLSAPASSASSEEDLLVSWQ---RAFVDRTPPP---AAVAQRTAFGRDA 438
            P          L+  +SSA+S  + L  +          +PPP    A     A+ R  
Sbjct: 586 GP---------DLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP 636

Query: 439 LPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISPEEERQS 498
            P L   F  +P        AP          LP  P +G P   + L   I   E  +S
Sbjct: 637 APPLA--FRGAPG-------AP----------LPWPPATG-PGSADGL-CTIYETEGPES 675

Query: 499 LLPINRGTEEGPGTSHTEGRAWPLPSSSRPQRSPKR 534
             P     + GP    + G+A     +    RSPK+
Sbjct: 676 ATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQ 711



 Score = 34.3 bits (77), Expect = 0.31
 Identities = 48/188 (25%), Positives = 73/188 (38%), Gaps = 20/188 (10%)

Query: 214 SPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGD 273
           SPGP  S  PG    T+    + +K   L +++ ++ + G+  A +      +S G   D
Sbjct: 101 SPGPVSS--PGRASGTTRPGPLGQK--GLRISAEETVARGK--ATEAPKRSALSAGARRD 154

Query: 274 PASPPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIE 333
             S P PG+P+P       + GT  G     LP PA     P   P PP    P + V  
Sbjct: 155 -TSGPTPGTPSPAMARRSRAAGTEVG-----LPRPA-----PSARPRPPTE-GPRKSVSS 202

Query: 334 FSEDKVRIPRNSP--LPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPS 391
            SE     P  +    P+     ++  S SL    +  + P+    +      +P H   
Sbjct: 203 ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 262

Query: 392 PAPLTLSA 399
           P P  L A
Sbjct: 263 PKPKGLQA 270



 Score = 34.3 bits (77), Expect = 0.31
 Identities = 70/295 (23%), Positives = 91/295 (30%), Gaps = 61/295 (20%)

Query: 201 MVRKHLHSGQEAASPGPAPSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDV 260
           M R+   +G E   P PAPS  P    PT    + +              +  RP A   
Sbjct: 167 MARRSRAAGTEVGLPRPAPSARPRP--PTEGPRKSVSSASEHSTTEPSPAARRRPSAGGG 224

Query: 261 FVH-VDMSEGVPGDPASPPAPGSPTPQPNGECHSLGTARGSPEEELPLP-AFEKLNPYPT 318
                  S      P S PA   P+ +        GT R       P P   + L P P 
Sbjct: 225 LQRPASRSLSSSATPLSSPARSGPSAR--------GTPRAPAHPSQPKPKGLQALRP-PQ 275

Query: 319 PSPPHPLYPGRRVIEFSEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPST 378
            +PP               K   P   PL +   AT                   P PS 
Sbjct: 276 VTPPR--------------KDAAPALGPLSSSPLAT-------------------PSPSA 302

Query: 379 PASAQASPHHQPSPAPLTLSAPASSASSEEDLLVSWQRAFVDRTP-PPAAVAQRTAFGRD 437
           P S  A P  Q  P+P   + P+ + +S     +    +F+   P  P A     A    
Sbjct: 303 PPSPSAPPSLQTLPSP-PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 361

Query: 438 ALPELQRHFAHSPADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISP 492
           ALP LQ               +P A P  S L  P+ P +        L  P SP
Sbjct: 362 ALPPLQ------------APPSPPASPPLSPLATPS-PQAPNALAVHLLQAPFSP 403


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 43/179 (24%), Positives = 82/179 (45%), Gaps = 11/179 (6%)

Query: 32   QEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKF 91
            QE     A+ ++ L E+ E+ +R  A+  +  + LE+E       L + LGQ+++E++  
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHK 1253

Query: 92   KDKF----RRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVEL 147
            K K     + LQ+  +  +R   EL DK+H L +   S    + +AE     L  ++  L
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 148  TNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRNHKFADLPCELQDMVRKHL 206
            +++L D +      E L E  R   N++ +L +  +         D   E +  + +H+
Sbjct: 1314 SSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 36/199 (18%)

Query: 8    KKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKL--LQEENEELRRRLASATRRTEA 65
            K+  +KA  E +EL  E   S+L +E+ L   +      L  E EE+R RLA+  +  E 
Sbjct: 865  KERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922

Query: 66   LERELE-------------------IGQDCLELELGQSREELDKFKDKFRRLQNSYTASQ 106
            +  E+E                   + Q  L+LE     E+L++ +   ++LQ     ++
Sbjct: 923  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-----EQLEEEEAARQKLQLEKVTAE 977

Query: 107  RTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEEL-N 165
               ++LED++  +   ++       K   +RK L+  I +LT  L + +     L +L N
Sbjct: 978  AKIKKLEDEILVMDDQNN-------KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030

Query: 166  ERYRLDCNLAVQLLKCNKS 184
            +   +   L V+L K  KS
Sbjct: 1031 KHESMISELEVRLKKEEKS 1049



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 28/138 (20%), Positives = 58/138 (42%), Gaps = 11/138 (7%)

Query: 31   EQEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDK 90
            E  + L  + +++ L+EE   L+ +L       + LER +      L ++L  S+++L  
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI----STLNIQLSDSKKKLQD 1382

Query: 91   FKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNK 150
            F      L+      Q+  + L  +    A+       A  K E  +  L  E+ +L   
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAA-------AYDKLEKTKNRLQQELDDLVVD 1435

Query: 151  LLDAKNTINKLEELNERY 168
            L + +  ++ LE+   ++
Sbjct: 1436 LDNQRQLVSNLEKKQRKF 1453



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 46/203 (22%), Positives = 79/203 (38%), Gaps = 39/203 (19%)

Query: 9    KPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRTEALER 68
            K   K+  E  +L+ ++ G   +  E + D      LQ +  EL+ +LA         E 
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIAD------LQAQIAELKMQLAKK-------EE 1090

Query: 69   ELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIF 128
            EL+     L+ E+ Q    L K +                  ELE  +  L     S   
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIR------------------ELEGHISDLQEDLDSERA 1132

Query: 129  AIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRN 188
            A  KAE  ++ L  E+  L  +L D  ++    +EL  +   +  +   L K      R+
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALDEETRS 1189

Query: 189  HKFADLPCELQDMVRKHLHSGQE 211
            H+      ++Q+M +KH  + +E
Sbjct: 1190 HE-----AQVQEMRQKHAQAVEE 1207



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 55/220 (25%), Positives = 89/220 (40%), Gaps = 37/220 (16%)

Query: 17   EHRELRLEIPGSRLEQEEPLTDAERMKLLQE-ENEELRRRLASATRRTEALE---RELEI 72
            E+ +    +    ++ +E L  AER +   + E EEL   LAS+     AL+   R LE 
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736

Query: 73   GQDCLELELGQSREELDKFKDKFRR-------LQNSYTASQRT-------NQELEDKLHT 118
                LE EL + +  ++   D+ R+       L N     + T        Q+LE +   
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 119  LASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL 178
            L S  H    A+K              + T   L+AK  I +LEE  E+   +   A + 
Sbjct: 1797 LRSKLHEMEGAVKSK-----------FKSTIAALEAK--IAQLEEQVEQEAREKQAATKS 1843

Query: 179  LKCNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPA 218
            LK      ++ K  ++  +++D  RK     +E A  G A
Sbjct: 1844 LK-----QKDKKLKEILLQVED-ERKMAEQYKEQAEKGNA 1877



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 48/216 (22%), Positives = 95/216 (43%), Gaps = 30/216 (13%)

Query: 4    AAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRT 63
            AA AKK   K   + ++L L+   +   +EE +   ++++ LQ + ++ +R L  A    
Sbjct: 1615 AAAAKK---KLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASR 1668

Query: 64   E---ALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
            +   A  +E E     LE +L Q +E+L               A++R  ++ + +   LA
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDL--------------AAAERARKQADLEKEELA 1714

Query: 121  SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL-- 178
                S +      + +++ L+  I +L  +L + +     +E +++R R     A QL  
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ---GNMEAMSDRVRKATQQAEQLSN 1771

Query: 179  -LKCNKSHFRNHKFADLPCELQDM-VRKHLHSGQEA 212
             L   +S  + ++ A    E Q+  +R  LH  + A
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 43/179 (24%), Positives = 82/179 (45%), Gaps = 11/179 (6%)

Query: 32   QEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKF 91
            QE     A+ ++ L E+ E+ +R  A+  +  + LE+E       L + LGQ+++E++  
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHK 1260

Query: 92   KDKF----RRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVEL 147
            K K     + LQ+  +  +R   EL DK+H L +   S    + +AE     L  ++  L
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 148  TNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRNHKFADLPCELQDMVRKHL 206
            +++L D +      E L E  R   N++ +L +  +         D   E +  + +H+
Sbjct: 1321 SSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 36/199 (18%)

Query: 8    KKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKL--LQEENEELRRRLASATRRTEA 65
            K+  +KA  E +EL  E   S+L +E+ L   +      L  E EE+R RLA+  +  E 
Sbjct: 872  KERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929

Query: 66   LERELE-------------------IGQDCLELELGQSREELDKFKDKFRRLQNSYTASQ 106
            +  E+E                   + Q  L+LE     E+L++ +   ++LQ     ++
Sbjct: 930  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-----EQLEEEEAARQKLQLEKVTAE 984

Query: 107  RTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEEL-N 165
               ++LED++  +   ++       K   +RK L+  I +LT  L + +     L +L N
Sbjct: 985  AKIKKLEDEILVMDDQNN-------KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037

Query: 166  ERYRLDCNLAVQLLKCNKS 184
            +   +   L V+L K  KS
Sbjct: 1038 KHESMISELEVRLKKEEKS 1056



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 28/138 (20%), Positives = 58/138 (42%), Gaps = 11/138 (7%)

Query: 31   EQEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDK 90
            E  + L  + +++ L+EE   L+ +L       + LER +      L ++L  S+++L  
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI----STLNIQLSDSKKKLQD 1389

Query: 91   FKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNK 150
            F      L+      Q+  + L  +    A+       A  K E  +  L  E+ +L   
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAA-------AYDKLEKTKNRLQQELDDLVVD 1442

Query: 151  LLDAKNTINKLEELNERY 168
            L + +  ++ LE+   ++
Sbjct: 1443 LDNQRQLVSNLEKKQRKF 1460



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 46/203 (22%), Positives = 79/203 (38%), Gaps = 39/203 (19%)

Query: 9    KPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRTEALER 68
            K   K+  E  +L+ ++ G   +  E + D      LQ +  EL+ +LA         E 
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIAD------LQAQIAELKMQLAKK-------EE 1097

Query: 69   ELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIF 128
            EL+     L+ E+ Q    L K +                  ELE  +  L     S   
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIR------------------ELEGHISDLQEDLDSERA 1139

Query: 129  AIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRN 188
            A  KAE  ++ L  E+  L  +L D  ++    +EL  +   +  +   L K      R+
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALDEETRS 1196

Query: 189  HKFADLPCELQDMVRKHLHSGQE 211
            H+      ++Q+M +KH  + +E
Sbjct: 1197 HE-----AQVQEMRQKHAQAVEE 1214



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 55/220 (25%), Positives = 89/220 (40%), Gaps = 37/220 (16%)

Query: 17   EHRELRLEIPGSRLEQEEPLTDAERMKLLQE-ENEELRRRLASATRRTEALE---RELEI 72
            E+ +    +    ++ +E L  AER +   + E EEL   LAS+     AL+   R LE 
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743

Query: 73   GQDCLELELGQSREELDKFKDKFRR-------LQNSYTASQRT-------NQELEDKLHT 118
                LE EL + +  ++   D+ R+       L N     + T        Q+LE +   
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 119  LASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL 178
            L S  H    A+K              + T   L+AK  I +LEE  E+   +   A + 
Sbjct: 1804 LRSKLHEMEGAVKSK-----------FKSTIAALEAK--IAQLEEQVEQEAREKQAATKS 1850

Query: 179  LKCNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPA 218
            LK      ++ K  ++  +++D  RK     +E A  G A
Sbjct: 1851 LK-----QKDKKLKEILLQVED-ERKMAEQYKEQAEKGNA 1884



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 48/216 (22%), Positives = 95/216 (43%), Gaps = 30/216 (13%)

Query: 4    AAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRT 63
            AA AKK   K   + ++L L+   +   +EE +   ++++ LQ + ++ +R L  A    
Sbjct: 1622 AAAAKK---KLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASR 1675

Query: 64   E---ALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
            +   A  +E E     LE +L Q +E+L               A++R  ++ + +   LA
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDL--------------AAAERARKQADLEKEELA 1721

Query: 121  SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL-- 178
                S +      + +++ L+  I +L  +L + +     +E +++R R     A QL  
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ---GNMEAMSDRVRKATQQAEQLSN 1778

Query: 179  -LKCNKSHFRNHKFADLPCELQDM-VRKHLHSGQEA 212
             L   +S  + ++ A    E Q+  +R  LH  + A
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 43/179 (24%), Positives = 82/179 (45%), Gaps = 11/179 (6%)

Query: 32   QEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKF 91
            QE     A+ ++ L E+ E+ +R  A+  +  + LE+E       L + LGQ+++E++  
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHK 1260

Query: 92   KDKF----RRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVEL 147
            K K     + LQ+  +  +R   EL DK+H L +   S    + +AE     L  ++  L
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 148  TNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRNHKFADLPCELQDMVRKHL 206
            +++L D +      E L E  R   N++ +L +  +         D   E +  + +H+
Sbjct: 1321 SSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1373



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 36/199 (18%)

Query: 8    KKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKL--LQEENEELRRRLASATRRTEA 65
            K+  +KA  E +EL  E   S+L +E+ L   +      L  E EE+R RLA+  +  E 
Sbjct: 872  KERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 929

Query: 66   LERELE-------------------IGQDCLELELGQSREELDKFKDKFRRLQNSYTASQ 106
            +  E+E                   + Q  L+LE     E+L++ +   ++LQ     ++
Sbjct: 930  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-----EQLEEEEAARQKLQLEKVTAE 984

Query: 107  RTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEEL-N 165
               ++LED++  +   ++       K   +RK L+  I +LT  L + +     L +L N
Sbjct: 985  AKIKKLEDEILVMDDQNN-------KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1037

Query: 166  ERYRLDCNLAVQLLKCNKS 184
            +   +   L V+L K  KS
Sbjct: 1038 KHESMISELEVRLKKEEKS 1056



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 28/138 (20%), Positives = 58/138 (42%), Gaps = 11/138 (7%)

Query: 31   EQEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDK 90
            E  + L  + +++ L+EE   L+ +L       + LER +      L ++L  S+++L  
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI----STLNIQLSDSKKKLQD 1389

Query: 91   FKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNK 150
            F      L+      Q+  + L  +    A+       A  K E  +  L  E+ +L   
Sbjct: 1390 FASTVEALEEGKKRFQKEIENLTQQYEEKAA-------AYDKLEKTKNRLQQELDDLVVD 1442

Query: 151  LLDAKNTINKLEELNERY 168
            L + +  ++ LE+   ++
Sbjct: 1443 LDNQRQLVSNLEKKQRKF 1460



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 46/203 (22%), Positives = 79/203 (38%), Gaps = 39/203 (19%)

Query: 9    KPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRTEALER 68
            K   K+  E  +L+ ++ G   +  E + D      LQ +  EL+ +LA         E 
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIAD------LQAQIAELKMQLAKK-------EE 1097

Query: 69   ELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIF 128
            EL+     L+ E+ Q    L K +                  ELE  +  L     S   
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIR------------------ELEGHISDLQEDLDSERA 1139

Query: 129  AIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRN 188
            A  KAE  ++ L  E+  L  +L D  ++    +EL  +   +  +   L K      R+
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALDEETRS 1196

Query: 189  HKFADLPCELQDMVRKHLHSGQE 211
            H+      ++Q+M +KH  + +E
Sbjct: 1197 HE-----AQVQEMRQKHAQAVEE 1214



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 55/220 (25%), Positives = 89/220 (40%), Gaps = 37/220 (16%)

Query: 17   EHRELRLEIPGSRLEQEEPLTDAERMKLLQE-ENEELRRRLASATRRTEALE---RELEI 72
            E+ +    +    ++ +E L  AER +   + E EEL   LAS+     AL+   R LE 
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1743

Query: 73   GQDCLELELGQSREELDKFKDKFRR-------LQNSYTASQRT-------NQELEDKLHT 118
                LE EL + +  ++   D+ R+       L N     + T        Q+LE +   
Sbjct: 1744 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1803

Query: 119  LASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL 178
            L S  H    A+K              + T   L+AK  I +LEE  E+   +   A + 
Sbjct: 1804 LRSKLHEMEGAVKSK-----------FKSTIAALEAK--IAQLEEQVEQEAREKQAATKS 1850

Query: 179  LKCNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPA 218
            LK      ++ K  ++  +++D  RK     +E A  G A
Sbjct: 1851 LK-----QKDKKLKEILLQVED-ERKMAEQYKEQAEKGNA 1884



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 48/216 (22%), Positives = 95/216 (43%), Gaps = 30/216 (13%)

Query: 4    AAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRT 63
            AA AKK   K   + ++L L+   +   +EE +   ++++ LQ + ++ +R L  A    
Sbjct: 1622 AAAAKK---KLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASR 1675

Query: 64   E---ALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
            +   A  +E E     LE +L Q +E+L               A++R  ++ + +   LA
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDL--------------AAAERARKQADLEKEELA 1721

Query: 121  SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL-- 178
                S +      + +++ L+  I +L  +L + +     +E +++R R     A QL  
Sbjct: 1722 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ---GNMEAMSDRVRKATQQAEQLSN 1778

Query: 179  -LKCNKSHFRNHKFADLPCELQDM-VRKHLHSGQEA 212
             L   +S  + ++ A    E Q+  +R  LH  + A
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 43/179 (24%), Positives = 82/179 (45%), Gaps = 11/179 (6%)

Query: 32   QEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKF 91
            QE     A+ ++ L E+ E+ +R  A+  +  + LE+E       L + LGQ+++E++  
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHK 1253

Query: 92   KDKF----RRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVEL 147
            K K     + LQ+  +  +R   EL DK+H L +   S    + +AE     L  ++  L
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 148  TNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRNHKFADLPCELQDMVRKHL 206
            +++L D +      E L E  R   N++ +L +  +         D   E +  + +H+
Sbjct: 1314 SSQLQDTQ------ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI 1366



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 36/199 (18%)

Query: 8    KKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKL--LQEENEELRRRLASATRRTEA 65
            K+  +KA  E +EL  E   S+L +E+ L   +      L  E EE+R RLA+  +  E 
Sbjct: 865  KERQQKAENELKEL--EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEE 922

Query: 66   LERELE-------------------IGQDCLELELGQSREELDKFKDKFRRLQNSYTASQ 106
            +  E+E                   + Q  L+LE     E+L++ +   ++LQ     ++
Sbjct: 923  ILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE-----EQLEEEEAARQKLQLEKVTAE 977

Query: 107  RTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEEL-N 165
               ++LED++  +   ++       K   +RK L+  I +LT  L + +     L +L N
Sbjct: 978  AKIKKLEDEILVMDDQNN-------KLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN 1030

Query: 166  ERYRLDCNLAVQLLKCNKS 184
            +   +   L V+L K  KS
Sbjct: 1031 KHESMISELEVRLKKEEKS 1049



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 28/138 (20%), Positives = 58/138 (42%), Gaps = 11/138 (7%)

Query: 31   EQEEPLTDAERMKLLQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDK 90
            E  + L  + +++ L+EE   L+ +L       + LER +      L ++L  S+++L  
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHI----STLNIQLSDSKKKLQD 1382

Query: 91   FKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNK 150
            F      L+      Q+  + L  +    A+       A  K E  +  L  E+ +L   
Sbjct: 1383 FASTVEALEEGKKRFQKEIENLTQQYEEKAA-------AYDKLEKTKNRLQQELDDLVVD 1435

Query: 151  LLDAKNTINKLEELNERY 168
            L + +  ++ LE+   ++
Sbjct: 1436 LDNQRQLVSNLEKKQRKF 1453



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 46/203 (22%), Positives = 79/203 (38%), Gaps = 39/203 (19%)

Query: 9    KPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRTEALER 68
            K   K+  E  +L+ ++ G   +  E + D      LQ +  EL+ +LA         E 
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIAD------LQAQIAELKMQLAKK-------EE 1090

Query: 69   ELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLASLSHSWIF 128
            EL+     L+ E+ Q    L K +                  ELE  +  L     S   
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIR------------------ELEGHISDLQEDLDSERA 1132

Query: 129  AIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQLLKCNKSHFRN 188
            A  KAE  ++ L  E+  L  +L D  ++    +EL  +   +  +   L K      R+
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALDEETRS 1189

Query: 189  HKFADLPCELQDMVRKHLHSGQE 211
            H+      ++Q+M +KH  + +E
Sbjct: 1190 HE-----AQVQEMRQKHAQAVEE 1207



 Score = 33.5 bits (75), Expect = 0.53
 Identities = 55/220 (25%), Positives = 89/220 (40%), Gaps = 37/220 (16%)

Query: 17   EHRELRLEIPGSRLEQEEPLTDAERMKLLQE-ENEELRRRLASATRRTEALE---RELEI 72
            E+ +    +    ++ +E L  AER +   + E EEL   LAS+     AL+   R LE 
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEA 1736

Query: 73   GQDCLELELGQSREELDKFKDKFRR-------LQNSYTASQRT-------NQELEDKLHT 118
                LE EL + +  ++   D+ R+       L N     + T        Q+LE +   
Sbjct: 1737 RIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKE 1796

Query: 119  LASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL 178
            L S  H    A+K              + T   L+AK  I +LEE  E+   +   A + 
Sbjct: 1797 LRSKLHEMEGAVKSK-----------FKSTIAALEAK--IAQLEEQVEQEAREKQAATKS 1843

Query: 179  LKCNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPA 218
            LK      ++ K  ++  +++D  RK     +E A  G A
Sbjct: 1844 LK-----QKDKKLKEILLQVED-ERKMAEQYKEQAEKGNA 1877



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 48/216 (22%), Positives = 95/216 (43%), Gaps = 30/216 (13%)

Query: 4    AAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKLLQEENEELRRRLASATRRT 63
            AA AKK   K   + ++L L+   +   +EE +   ++++ LQ + ++ +R L  A    
Sbjct: 1615 AAAAKK---KLEGDLKDLELQADSAIKGREEAI---KQLRKLQAQMKDFQRELEDARASR 1668

Query: 64   E---ALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSYTASQRTNQELEDKLHTLA 120
            +   A  +E E     LE +L Q +E+L               A++R  ++ + +   LA
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDL--------------AAAERARKQADLEKEELA 1714

Query: 121  SLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINKLEELNERYRLDCNLAVQL-- 178
                S +      + +++ L+  I +L  +L + +     +E +++R R     A QL  
Sbjct: 1715 EELASSLSGRNALQDEKRRLEARIAQLEEELEEEQ---GNMEAMSDRVRKATQQAEQLSN 1771

Query: 179  -LKCNKSHFRNHKFADLPCELQDM-VRKHLHSGQEA 212
             L   +S  + ++ A    E Q+  +R  LH  + A
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.129    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,653,564
Number of Sequences: 37866
Number of extensions: 1798014
Number of successful extensions: 16965
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 1260
Number of HSP's that attempted gapping in prelim test: 11450
Number of HSP's gapped (non-prelim): 5590
length of query: 557
length of database: 18,247,518
effective HSP length: 107
effective length of query: 450
effective length of database: 14,195,856
effective search space: 6388135200
effective search space used: 6388135200
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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