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Search of human proteins with 22538442
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22538442 cathepsin Z preproprotein [Homo sapiens]
(303 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22538442 cathepsin Z preproprotein [Homo sapiens] 660 0.0
gi|189083844 cathepsin C isoform a preproprotein [Homo sapiens] 118 6e-27
gi|23110962 cathepsin S preproprotein [Homo sapiens] 105 4e-23
gi|4557501 cathepsin O preproprotein [Homo sapiens] 96 4e-20
gi|23110960 cathepsin L2 preproprotein [Homo sapiens] 94 1e-19
gi|23110957 cathepsin H isoform b precursor [Homo sapiens] 93 3e-19
gi|23110955 cathepsin H isoform a preproprotein [Homo sapiens] 93 3e-19
gi|22538437 cathepsin B preproprotein [Homo sapiens] 92 6e-19
gi|22538435 cathepsin B preproprotein [Homo sapiens] 92 6e-19
gi|22538433 cathepsin B preproprotein [Homo sapiens] 92 6e-19
gi|22538431 cathepsin B preproprotein [Homo sapiens] 92 6e-19
gi|4503139 cathepsin B preproprotein [Homo sapiens] 92 6e-19
gi|22202619 cathepsin L1 preproprotein [Homo sapiens] 91 1e-18
gi|4503155 cathepsin L1 preproprotein [Homo sapiens] 91 1e-18
gi|4503151 cathepsin K preproprotein [Homo sapiens] 91 2e-18
gi|224586907 tubulointerstitial nephritis antigen [Homo sapiens] 88 1e-17
gi|11545918 tubulointerstitial nephritis antigen-like 1 [Homo sa... 79 4e-15
gi|23110964 cathepsin W preproprotein [Homo sapiens] 69 5e-12
gi|6042196 cathepsin F [Homo sapiens] 66 3e-11
gi|215820652 StAR-related lipid transfer (START) domain containi... 30 2.0
gi|215820650 StAR-related lipid transfer (START) domain containi... 30 2.0
gi|31543659 StAR-related lipid transfer (START) domain containin... 30 2.0
gi|25121982 acidic epididymal glycoprotein-like 1 isoform 1 prec... 30 3.4
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 29 5.9
gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo sapi... 29 5.9
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 29 5.9
gi|126032348 hect domain and RLD 2 [Homo sapiens] 28 7.7
gi|143770741 glycoprotein VI (platelet) isoform 1 [Homo sapiens] 28 7.7
gi|239750972 PREDICTED: hypothetical protein XP_002347620 [Homo ... 28 7.7
gi|239745378 PREDICTED: hypothetical protein XP_002343450 [Homo ... 28 7.7
>gi|22538442 cathepsin Z preproprotein [Homo sapiens]
Length = 303
Score = 660 bits (1702), Expect = 0.0
Identities = 303/303 (100%), Positives = 303/303 (100%)
Query: 1 MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA 60
MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA
Sbjct: 1 MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPA 60
Query: 61 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV 120
DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV
Sbjct: 61 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV 120
Query: 121 QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH 180
QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH
Sbjct: 121 QNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECH 180
Query: 181 AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN 240
AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN
Sbjct: 181 AIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN 240
Query: 241 HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD 300
HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD
Sbjct: 241 HVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGD 300
Query: 301 PIV 303
PIV
Sbjct: 301 PIV 303
>gi|189083844 cathepsin C isoform a preproprotein [Homo sapiens]
Length = 463
Score = 118 bits (296), Expect = 6e-27
Identities = 77/228 (33%), Positives = 105/228 (46%), Gaps = 23/228 (10%)
Query: 62 LPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQ 121
LP SWDWRNV G+N+ S RNQ CGSC++ AS + RI I + + +LS Q
Sbjct: 231 LPTSWDWRNVHGINFVSPVRNQ---ASCGSCYSFASMGMLEARIRILTNNS-QTPILSPQ 286
Query: 122 NVIDCGN-AGSCEGGND-LSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKEC 179
V+ C A CEGG L YA G+ +E C Y D C C F+
Sbjct: 287 EVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDC-----FRYY 341
Query: 180 HAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAE------Y 233
+ +Y VG + M E+ +GP++ + +Y GIY +
Sbjct: 342 SSEYHY----VGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPF 397
Query: 234 QDTTYINHVVSVAGWGI--SDGTEYWIVRNSWGEPWGERGWLRIVTST 279
NH V + G+G + G +YWIV+NSWG WGE G+ RI T
Sbjct: 398 NPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGT 445
>gi|23110962 cathepsin S preproprotein [Homo sapiens]
Length = 331
Score = 105 bits (263), Expect = 4e-23
Identities = 75/224 (33%), Positives = 109/224 (48%), Gaps = 36/224 (16%)
Query: 62 LPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQ 121
LP S DWR V + CG+CWA ++ A+ ++ +K G S LS Q
Sbjct: 115 LPDSVDWREKGCVTEVKYQGS------CGACWAFSAVGALEAQLKLKT-GKLVS--LSAQ 165
Query: 122 NVIDC-----GNAGSCEGGNDLSVWDYAHQH-GIPDETCNNYQAKDQEC--DKFNQCGTC 173
N++DC GN G C GG + + Y + GI + Y+A DQ+C D + TC
Sbjct: 166 NLVDCSTEKYGNKG-CNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATC 224
Query: 174 NEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMATE-RLANYTGGIYA 231
+++ E GRE ++ E AN GP+S G+ A Y G+Y
Sbjct: 225 SKYTELPY----------------GREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYY 268
Query: 232 EYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRI 275
E T +NH V V G+G +G EYW+V+NSWG +GE G++R+
Sbjct: 269 EPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRM 312
>gi|4557501 cathepsin O preproprotein [Homo sapiens]
Length = 321
Score = 95.9 bits (237), Expect = 4e-20
Identities = 73/236 (30%), Positives = 104/236 (44%), Gaps = 30/236 (12%)
Query: 48 STYPR----PHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMAD 103
S +PR H + LP +DWR+ V RNQ Q CG CWA + A+
Sbjct: 90 SKFPRYSAEVHMSIPNVSLPLRFDWRDKQVVTQV---RNQ---QMCGGCWAFSVVGAVES 143
Query: 104 RINIKRKGAWPSTLLSVQNVIDCG-NAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQ 162
IK K P LSVQ VIDC N C GG+ L+ ++ ++ + KD
Sbjct: 144 AYAIKGK---PLEDLSVQQVIDCSYNNYGCNGGSTLNALNWLNKMQVK-------LVKDS 193
Query: 163 ECDKFNQCGTCNEFKECHA---IRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMAT 219
E Q G C+ F H+ I+ Y+ + D ++M + GP+ + A
Sbjct: 194 EYPFKAQNGLCHYFSGSHSGFSIKGYSAYDFSDQ-----EDEMAKALLTFGPLVVIVDAV 248
Query: 220 ERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRI 275
+Y GGI + + NH V + G+ + T YWIVRNSWG WG G+ +
Sbjct: 249 S-WQDYLGGIIQHHCSSGEANHAVLITGFDKTGSTPYWIVRNSWGSSWGVDGYAHV 303
>gi|23110960 cathepsin L2 preproprotein [Homo sapiens]
Length = 334
Score = 94.0 bits (232), Expect = 1e-19
Identities = 74/227 (32%), Positives = 114/227 (50%), Gaps = 36/227 (15%)
Query: 61 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV 120
DLPKS DWR Y + +NQ + CGSCWA ++T A+ ++ ++ G S LS
Sbjct: 113 DLPKSVDWRKK---GYVTPVKNQ---KQCGSCWAFSATGALEGQM-FRKTGKLVS--LSE 163
Query: 121 QNVIDC----GNAGSCEGGNDLSVWDYAHQHG-IPDETCNNYQAKDQECDKFNQCGTCNE 175
QN++DC GN G C GG + Y ++G + E Y A D+ C +
Sbjct: 164 QNLVDCSRPQGNQG-CNGGFMARAFQYVKENGGLDSEESYPYVAVDEIC----------K 212
Query: 176 FKECHAIRNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMATERLAN-YTGGIYAEY 233
++ +++ N T + V G+EK + + A GPIS + A Y GIY E
Sbjct: 213 YRPENSVANDTGFTV----VAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEP 268
Query: 234 Q-DTTYINHVVSVAGWGI----SDGTEYWIVRNSWGEPWGERGWLRI 275
+ ++H V V G+G S+ ++YW+V+NSWG WG G+++I
Sbjct: 269 DCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKI 315
>gi|23110957 cathepsin H isoform b precursor [Homo sapiens]
Length = 323
Score = 93.2 bits (230), Expect = 3e-19
Identities = 67/220 (30%), Positives = 95/220 (43%), Gaps = 28/220 (12%)
Query: 63 PKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQN 122
P S DWR N+ S +NQ CGSCW ++T A+ I I L+ Q
Sbjct: 105 PPSVDWRKKG--NFVSPVKNQGA---CGSCWTFSTTGALESAIAI---ATGKMLSLAEQQ 156
Query: 123 VIDCG---NAGSCEGGNDLSVWDYA-HQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKE 178
++DC N C+GG ++Y + GI E YQ KD C KF K+
Sbjct: 157 LVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYC-KFQPGKAIGFVKD 215
Query: 179 CHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAE---YQD 235
+ N T++ E M+ + P+S T+ Y GIY+ ++
Sbjct: 216 ---VANITIY---------DEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKT 263
Query: 236 TTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRI 275
+NH V G+G +G YWIV+NSWG WG G+ I
Sbjct: 264 PDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLI 303
>gi|23110955 cathepsin H isoform a preproprotein [Homo sapiens]
Length = 335
Score = 93.2 bits (230), Expect = 3e-19
Identities = 67/220 (30%), Positives = 95/220 (43%), Gaps = 28/220 (12%)
Query: 63 PKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQN 122
P S DWR N+ S +NQ CGSCW ++T A+ I I L+ Q
Sbjct: 117 PPSVDWRKKG--NFVSPVKNQGA---CGSCWTFSTTGALESAIAI---ATGKMLSLAEQQ 168
Query: 123 VIDCG---NAGSCEGGNDLSVWDYA-HQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKE 178
++DC N C+GG ++Y + GI E YQ KD C KF K+
Sbjct: 169 LVDCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYC-KFQPGKAIGFVKD 227
Query: 179 CHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAE---YQD 235
+ N T++ E M+ + P+S T+ Y GIY+ ++
Sbjct: 228 ---VANITIY---------DEEAMVEAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKT 275
Query: 236 TTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRI 275
+NH V G+G +G YWIV+NSWG WG G+ I
Sbjct: 276 PDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFLI 315
>gi|22538437 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 92.0 bits (227), Expect = 6e-19
Identities = 61/212 (28%), Positives = 90/212 (42%), Gaps = 27/212 (12%)
Query: 89 CGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNA---GSCEGGNDLSVWDYAH 145
CGSCWA + A++DRI I A S +S ++++ C + C GG W++
Sbjct: 105 CGSCWAFGAVEAISDRICI-HTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWT 163
Query: 146 QHGI-------PDETCNNYQAKDQE---------CDKFNQCGTCNEFKECHAIRNYTLWR 189
+ G+ C Y E C C+ K C + T +
Sbjct: 164 RKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCS--KICEPGYSPTYKQ 221
Query: 190 VGDYG----SLSGREK-MMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVS 244
YG S+S EK +MAEIY NGP+ Y G+Y H +
Sbjct: 222 DKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIR 281
Query: 245 VAGWGISDGTEYWIVRNSWGEPWGERGWLRIV 276
+ GWG+ +GT YW+V NSW WG+ G+ +I+
Sbjct: 282 ILGWGVENGTPYWLVANSWNTDWGDNGFFKIL 313
>gi|22538435 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 92.0 bits (227), Expect = 6e-19
Identities = 61/212 (28%), Positives = 90/212 (42%), Gaps = 27/212 (12%)
Query: 89 CGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNA---GSCEGGNDLSVWDYAH 145
CGSCWA + A++DRI I A S +S ++++ C + C GG W++
Sbjct: 105 CGSCWAFGAVEAISDRICI-HTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWT 163
Query: 146 QHGI-------PDETCNNYQAKDQE---------CDKFNQCGTCNEFKECHAIRNYTLWR 189
+ G+ C Y E C C+ K C + T +
Sbjct: 164 RKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCS--KICEPGYSPTYKQ 221
Query: 190 VGDYG----SLSGREK-MMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVS 244
YG S+S EK +MAEIY NGP+ Y G+Y H +
Sbjct: 222 DKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIR 281
Query: 245 VAGWGISDGTEYWIVRNSWGEPWGERGWLRIV 276
+ GWG+ +GT YW+V NSW WG+ G+ +I+
Sbjct: 282 ILGWGVENGTPYWLVANSWNTDWGDNGFFKIL 313
>gi|22538433 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 92.0 bits (227), Expect = 6e-19
Identities = 61/212 (28%), Positives = 90/212 (42%), Gaps = 27/212 (12%)
Query: 89 CGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNA---GSCEGGNDLSVWDYAH 145
CGSCWA + A++DRI I A S +S ++++ C + C GG W++
Sbjct: 105 CGSCWAFGAVEAISDRICI-HTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWT 163
Query: 146 QHGI-------PDETCNNYQAKDQE---------CDKFNQCGTCNEFKECHAIRNYTLWR 189
+ G+ C Y E C C+ K C + T +
Sbjct: 164 RKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCS--KICEPGYSPTYKQ 221
Query: 190 VGDYG----SLSGREK-MMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVS 244
YG S+S EK +MAEIY NGP+ Y G+Y H +
Sbjct: 222 DKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIR 281
Query: 245 VAGWGISDGTEYWIVRNSWGEPWGERGWLRIV 276
+ GWG+ +GT YW+V NSW WG+ G+ +I+
Sbjct: 282 ILGWGVENGTPYWLVANSWNTDWGDNGFFKIL 313
>gi|22538431 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 92.0 bits (227), Expect = 6e-19
Identities = 61/212 (28%), Positives = 90/212 (42%), Gaps = 27/212 (12%)
Query: 89 CGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNA---GSCEGGNDLSVWDYAH 145
CGSCWA + A++DRI I A S +S ++++ C + C GG W++
Sbjct: 105 CGSCWAFGAVEAISDRICI-HTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWT 163
Query: 146 QHGI-------PDETCNNYQAKDQE---------CDKFNQCGTCNEFKECHAIRNYTLWR 189
+ G+ C Y E C C+ K C + T +
Sbjct: 164 RKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCS--KICEPGYSPTYKQ 221
Query: 190 VGDYG----SLSGREK-MMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVS 244
YG S+S EK +MAEIY NGP+ Y G+Y H +
Sbjct: 222 DKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIR 281
Query: 245 VAGWGISDGTEYWIVRNSWGEPWGERGWLRIV 276
+ GWG+ +GT YW+V NSW WG+ G+ +I+
Sbjct: 282 ILGWGVENGTPYWLVANSWNTDWGDNGFFKIL 313
>gi|4503139 cathepsin B preproprotein [Homo sapiens]
Length = 339
Score = 92.0 bits (227), Expect = 6e-19
Identities = 61/212 (28%), Positives = 90/212 (42%), Gaps = 27/212 (12%)
Query: 89 CGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNA---GSCEGGNDLSVWDYAH 145
CGSCWA + A++DRI I A S +S ++++ C + C GG W++
Sbjct: 105 CGSCWAFGAVEAISDRICI-HTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWT 163
Query: 146 QHGI-------PDETCNNYQAKDQE---------CDKFNQCGTCNEFKECHAIRNYTLWR 189
+ G+ C Y E C C+ K C + T +
Sbjct: 164 RKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCS--KICEPGYSPTYKQ 221
Query: 190 VGDYG----SLSGREK-MMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVS 244
YG S+S EK +MAEIY NGP+ Y G+Y H +
Sbjct: 222 DKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIR 281
Query: 245 VAGWGISDGTEYWIVRNSWGEPWGERGWLRIV 276
+ GWG+ +GT YW+V NSW WG+ G+ +I+
Sbjct: 282 ILGWGVENGTPYWLVANSWNTDWGDNGFFKIL 313
>gi|22202619 cathepsin L1 preproprotein [Homo sapiens]
Length = 333
Score = 90.9 bits (224), Expect = 1e-18
Identities = 75/231 (32%), Positives = 114/231 (49%), Gaps = 45/231 (19%)
Query: 61 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV 120
+ P+S DWR Y + +NQ CGSCWA ++T A+ ++ ++ G S LS
Sbjct: 113 EAPRSVDWREK---GYVTPVKNQG---QCGSCWAFSATGALEGQM-FRKTGRLIS--LSE 163
Query: 121 QNVIDC----GNAGSCEGGNDLSVWDYAHQH-----GIPDETCNNYQAKDQECDKFNQCG 171
QN++DC GN G C GG + DYA Q+ G+ E Y+A ++ C K+N
Sbjct: 164 QNLVDCSGPQGNEG-CNGG----LMDYAFQYVQDNGGLDSEESYPYEATEESC-KYNP-- 215
Query: 172 TCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMAT-ERLANYTGGI 229
Y++ + + +EK + + A GPIS I A E Y GI
Sbjct: 216 ------------KYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI 263
Query: 230 YAEYQDTTY-INHVVSVAGWGI----SDGTEYWIVRNSWGEPWGERGWLRI 275
Y E ++ ++H V V G+G SD +YW+V+NSWGE WG G++++
Sbjct: 264 YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKM 314
>gi|4503155 cathepsin L1 preproprotein [Homo sapiens]
Length = 333
Score = 90.9 bits (224), Expect = 1e-18
Identities = 75/231 (32%), Positives = 114/231 (49%), Gaps = 45/231 (19%)
Query: 61 DLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSV 120
+ P+S DWR Y + +NQ CGSCWA ++T A+ ++ ++ G S LS
Sbjct: 113 EAPRSVDWREK---GYVTPVKNQG---QCGSCWAFSATGALEGQM-FRKTGRLIS--LSE 163
Query: 121 QNVIDC----GNAGSCEGGNDLSVWDYAHQH-----GIPDETCNNYQAKDQECDKFNQCG 171
QN++DC GN G C GG + DYA Q+ G+ E Y+A ++ C K+N
Sbjct: 164 QNLVDCSGPQGNEG-CNGG----LMDYAFQYVQDNGGLDSEESYPYEATEESC-KYNP-- 215
Query: 172 TCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMAT-ERLANYTGGI 229
Y++ + + +EK + + A GPIS I A E Y GI
Sbjct: 216 ------------KYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGI 263
Query: 230 YAEYQDTTY-INHVVSVAGWGI----SDGTEYWIVRNSWGEPWGERGWLRI 275
Y E ++ ++H V V G+G SD +YW+V+NSWGE WG G++++
Sbjct: 264 YFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKM 314
>gi|4503151 cathepsin K preproprotein [Homo sapiens]
Length = 329
Score = 90.5 bits (223), Expect = 2e-18
Identities = 65/216 (30%), Positives = 105/216 (48%), Gaps = 26/216 (12%)
Query: 66 WDWRNVDGVNYAS---ITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQN 122
W+ R D V+Y +T ++ Q CGSCWA +S A+ ++ K+ G + LS QN
Sbjct: 111 WEGRAPDSVDYRKKGYVTPVKNQGQ-CGSCWAFSSVGALEGQLK-KKTGKLLN--LSPQN 166
Query: 123 VIDCGNAGS-CEGGNDLSVWDYAHQH-GIPDETCNNYQAKDQECDKFNQCGTCNEFKECH 180
++DC + C GG + + Y ++ GI E Y +++ C +N G +C
Sbjct: 167 LVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESC-MYNPTGKA---AKCR 222
Query: 181 AIRNYTLWRVGDYGSLSGREKMMAEIYAN-GPISCGIMAT-ERLANYTGGIYAEYQ-DTT 237
R G EK + A GP+S I A+ Y+ G+Y + ++
Sbjct: 223 GYREIP----------EGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSD 272
Query: 238 YINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWL 273
+NH V G+GI G ++WI++NSWGE WG +G++
Sbjct: 273 NLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYI 308
>gi|224586907 tubulointerstitial nephritis antigen [Homo sapiens]
Length = 476
Score = 87.8 bits (216), Expect = 1e-17
Identities = 61/213 (28%), Positives = 94/213 (44%), Gaps = 26/213 (12%)
Query: 89 CGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDC--GNAGSCEGGNDLSVWDYAHQ 146
C + WA ++ S ADRI I+ KG + + L S QN+I C N C G+ W Y +
Sbjct: 240 CAASWAFSTASVAADRIAIQSKGRYTANL-SPQNLISCCAKNRHGCNSGSIDRAWWYLRK 298
Query: 147 HGIPDETC----NNYQAKDQECDKFNQC---GTCNEFKEC--HAIRNYTLWRVGD-YGSL 196
G+ C + A + C ++ G + K C + ++ +++ Y
Sbjct: 299 RGLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVS 358
Query: 197 SGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYIN--------HVVSVAGW 248
S ++M EI NGP+ + E +Y GIY T + H V + GW
Sbjct: 359 SNETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGW 418
Query: 249 GISDGTE-----YWIVRNSWGEPWGERGWLRIV 276
G G + +WI NSWG+ WGE G+ RI+
Sbjct: 419 GTLRGAQGQKEKFWIAANSWGKSWGENGYFRIL 451
>gi|11545918 tubulointerstitial nephritis antigen-like 1 [Homo
sapiens]
Length = 467
Score = 79.3 bits (194), Expect = 4e-15
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 29/216 (13%)
Query: 89 CGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGN--AGSCEGGNDLSVWDYAHQ 146
C WA ++ + +DR++I G + +LS QN++ C C GG W + +
Sbjct: 226 CAGSWAFSTAAVASDRVSIHSLGHM-TPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRR 284
Query: 147 HGIPDETCNNYQAKDQE-------CDKFNQC-GTCNEFKECHA----IRNYTLWRVGDYG 194
G+ + C + ++++ C ++ G H + N +++V
Sbjct: 285 RGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVY 344
Query: 195 SLSGREK-MMAEIYANGPISCGIMATERLANYTGGIYAEYQDTT--------YINHVVSV 245
L +K +M E+ NGP+ + E Y GGIY+ + + H V +
Sbjct: 345 RLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKI 404
Query: 246 AGWG---ISDGT--EYWIVRNSWGEPWGERGWLRIV 276
GWG + DG +YW NSWG WGERG RIV
Sbjct: 405 TGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIV 440
>gi|23110964 cathepsin W preproprotein [Homo sapiens]
Length = 376
Score = 68.9 bits (167), Expect = 5e-12
Identities = 72/271 (26%), Positives = 106/271 (39%), Gaps = 59/271 (21%)
Query: 34 YRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCW 93
YR G G+ +GR E +P S DWR V G S ++Q + C CW
Sbjct: 105 YRRAAG-GVPSMGREIRSEEPE----ESVPFSCDWRKVAGA--ISPIKDQ---KNCNCCW 154
Query: 94 AHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGS-CEGGNDLSVWD----YAHQHG 148
A A+ + + R W +SVQ ++DCG G C GG VWD + G
Sbjct: 155 AMAAAGNIE---TLWRISFWDFVDVSVQELLDCGRCGDGCHGG---FVWDAFITVLNNSG 208
Query: 149 IPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYA 208
+ E +Q K + CH + + + D+ L E +A+ A
Sbjct: 209 LASEKDYPFQGKVRA-------------HRCHPKKYQKVAWIQDFIMLQNNEHRIAQYLA 255
Query: 209 N-GPISCGIMATERLANYTGGIYAEYQ---DTTYINHVVSVAGWGISDGTE--------- 255
GPI+ I + L Y G+ D ++H V + G+G E
Sbjct: 256 TYGPITVTINM-KPLQLYRKGVIKATPTTCDPQLVDHSVLLVGFGSVKSEEGIWAETVSS 314
Query: 256 -----------YWIVRNSWGEPWGERGWLRI 275
YWI++NSWG WGE+G+ R+
Sbjct: 315 QSQPQPPHPTPYWILKNSWGAQWGEKGYFRL 345
>gi|6042196 cathepsin F [Homo sapiens]
Length = 484
Score = 66.2 bits (160), Expect = 3e-11
Identities = 62/221 (28%), Positives = 93/221 (42%), Gaps = 41/221 (18%)
Query: 63 PKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAW---PSTLLS 119
P WDWR+ V ++Q + CGSCWA + T + +G W TLLS
Sbjct: 272 PPEWDWRSKGAVTKV---KDQGM---CGSCWAFSVTGNV--------EGQWFLNQGTLLS 317
Query: 120 V--QNVIDCGNAG-SCEGGNDLSVWD-YAHQHGIPDETCNNYQAKDQECDKFNQCGTCNE 175
+ Q ++DC +C GG + + + G+ E +YQ Q C+
Sbjct: 318 LSEQELLDCDKMDKACMGGLPSNAYSAIKNLGGLETEDDYSYQGHMQSCNF--------- 368
Query: 176 FKECHAIRNYTLWRVGDYGSLSGRE-KMMAEIYANGPISCGIMATERLANYTGGIYAEYQ 234
+ Y + D LS E K+ A + GPIS I A + Y GI +
Sbjct: 369 --SAEKAKVY----INDSVELSQNEQKLAAWLAKRGPISVAINAFG-MQFYRHGISRPLR 421
Query: 235 DTT---YINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGW 272
I+H V + G+G +W ++NSWG WGE+G+
Sbjct: 422 PLCSPWLIDHAVLLVGYGNRSDVPFWAIKNSWGTDWGEKGY 462
>gi|215820652 StAR-related lipid transfer (START) domain containing
8 isoform b [Homo sapiens]
Length = 1023
Score = 30.4 bits (67), Expect = 2.0
Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 7/67 (10%)
Query: 191 GDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGI 250
G GS + + E+Y P+ G A + +GG YA D + HV WG+
Sbjct: 266 GSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDD--ILQHV-----WGL 318
Query: 251 SDGTEYW 257
E W
Sbjct: 319 QQRVELW 325
>gi|215820650 StAR-related lipid transfer (START) domain containing
8 isoform a [Homo sapiens]
Length = 1103
Score = 30.4 bits (67), Expect = 2.0
Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 7/67 (10%)
Query: 191 GDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGI 250
G GS + + E+Y P+ G A + +GG YA D + HV WG+
Sbjct: 346 GSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDD--ILQHV-----WGL 398
Query: 251 SDGTEYW 257
E W
Sbjct: 399 QQRVELW 405
>gi|31543659 StAR-related lipid transfer (START) domain containing 8
isoform b [Homo sapiens]
Length = 1023
Score = 30.4 bits (67), Expect = 2.0
Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 7/67 (10%)
Query: 191 GDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGI 250
G GS + + E+Y P+ G A + +GG YA D + HV WG+
Sbjct: 266 GSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEESGGSYAHLDD--ILQHV-----WGL 318
Query: 251 SDGTEYW 257
E W
Sbjct: 319 QQRVELW 325
>gi|25121982 acidic epididymal glycoprotein-like 1 isoform 1
precursor [Homo sapiens]
Length = 249
Score = 29.6 bits (65), Expect = 3.4
Identities = 28/121 (23%), Positives = 45/121 (37%), Gaps = 21/121 (17%)
Query: 68 WRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCG 127
W +V GV Y+ T +H W D + W ++ L + C
Sbjct: 112 WSSVIGVWYSESTSFKH------GEWTTTDDDITTDHYT---QIVWATSYLIGCAIASCR 162
Query: 128 NAGS---------CEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKE 178
GS C GND + ++ G+P E C + +D+ C N C +E+ +
Sbjct: 163 QQGSPRYLYVCHYCHEGNDPETKNEPYKTGVPCEACPS-NCEDKLCT--NPCIYYDEYFD 219
Query: 179 C 179
C
Sbjct: 220 C 220
>gi|45120119 microtubule associated serine/threonine kinase 1
[Homo sapiens]
Length = 1570
Score = 28.9 bits (63), Expect = 5.9
Identities = 20/65 (30%), Positives = 28/65 (43%), Gaps = 6/65 (9%)
Query: 23 GGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYL------SPADLPKSWDWRNVDGVNY 76
GG FRR ++C R + T PRPH L SP D P+++ ++
Sbjct: 19 GGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSF 78
Query: 77 ASITR 81
AS R
Sbjct: 79 ASSRR 83
>gi|55743080 ADAM metallopeptidase domain 2 proprotein [Homo
sapiens]
Length = 735
Score = 28.9 bits (63), Expect = 5.9
Identities = 12/31 (38%), Positives = 15/31 (48%)
Query: 155 NNYQAKDQECDKFNQCGTCNEFKECHAIRNY 185
++Y D DK N G CN K CH +Y
Sbjct: 609 SSYLGYDCTTDKCNDRGVCNNKKHCHCSASY 639
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 28.9 bits (63), Expect = 5.9
Identities = 18/68 (26%), Positives = 28/68 (41%), Gaps = 20/68 (29%)
Query: 126 CGNAGSCEGGNDLSVWDYAHQHGIPDE----------TCNNYQ--AKDQECDKFNQCGTC 173
C C G+D +H P TC+N+Q +K+ CD N CG
Sbjct: 1086 CDKRNDCVDGSD--------EHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDG 1137
Query: 174 NEFKECHA 181
++ K C++
Sbjct: 1138 SDEKNCNS 1145
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 28.5 bits (62), Expect = 7.7
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 7/52 (13%)
Query: 248 WGISDGTEYWIVRNSWGEPWGERGWLRIV-----TSTYKDGKGARYNLAIEE 294
WG DG + R GE GE GW+R+ T++Y+ GK +Y+L + E
Sbjct: 1881 WGDQDGPPPGLGRVI-GE-LGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLAE 1930
>gi|143770741 glycoprotein VI (platelet) isoform 1 [Homo sapiens]
Length = 620
Score = 28.5 bits (62), Expect = 7.7
Identities = 22/84 (26%), Positives = 35/84 (41%), Gaps = 2/84 (2%)
Query: 43 APLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMA 102
+P G S P H+ D+P+ D N GV+ + + + P G A A+++ A
Sbjct: 256 SPAGESCPPVLHQGQPGPDMPRGCDPNNPGGVSGRGLAQPEEAPAAQGQGCAEAASAPPA 315
Query: 103 DRIN--IKRKGAWPSTLLSVQNVI 124
+ I R W T S V+
Sbjct: 316 PPADPEITRGSGWRPTGCSQPRVM 339
>gi|239750972 PREDICTED: hypothetical protein XP_002347620 [Homo
sapiens]
Length = 259
Score = 28.5 bits (62), Expect = 7.7
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 8 WRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWD 67
W P ++ V +A + + GQ RG PLG ST P PH +L L S+
Sbjct: 144 WVPSMISVASLVSASSAVAWADGQKD----RGQPWLPLGPSTAPGPHTHLDDILLGVSYH 199
Query: 68 WRNV 71
R +
Sbjct: 200 GREL 203
>gi|239745378 PREDICTED: hypothetical protein XP_002343450 [Homo
sapiens]
Length = 259
Score = 28.5 bits (62), Expect = 7.7
Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 4/64 (6%)
Query: 8 WRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWD 67
W P ++ V +A + + GQ RG PLG ST P PH +L L S+
Sbjct: 144 WVPSMISVASLVSASSAVAWADGQKD----RGQPWLPLGPSTAPGPHTHLDDILLGVSYH 199
Query: 68 WRNV 71
R +
Sbjct: 200 GREL 203
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.463
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,068,718
Number of Sequences: 37866
Number of extensions: 620389
Number of successful extensions: 1214
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1157
Number of HSP's gapped (non-prelim): 44
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.