Search of human proteins with 224994171

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224994171 roundabout 1 isoform c [Homo sapiens]
         (1606 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224994171 roundabout 1 isoform c [Homo sapiens]                   3271   0.0  
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...  3258   0.0  
gi|19743806 roundabout 1 isoform b [Homo sapiens]                    3252   0.0  
gi|4506569 roundabout 1 isoform a [Homo sapiens]                     3214   0.0  
gi|224994173 roundabout 1 isoform d [Homo sapiens]                   3111   0.0  
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...  3102   0.0  
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...  1395   0.0  
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...  1395   0.0  
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   950   0.0  
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...   234   5e-61
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   226   1e-58
gi|118572606 hemicentin 1 [Homo sapiens]                              218   4e-56
gi|157311649 neogenin homolog 1 [Homo sapiens]                        218   4e-56
gi|28373129 contactin 5 isoform short [Homo sapiens]                  214   4e-55
gi|7657359 contactin 5 isoform long [Homo sapiens]                    214   5e-55
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            207   9e-53
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   205   3e-52
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   204   4e-52
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   204   4e-52
gi|222352127 sidekick 2 [Homo sapiens]                                204   7e-52
gi|119220552 sidekick 1 [Homo sapiens]                                202   3e-51
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           201   4e-51
gi|75709184 contactin 3 [Homo sapiens]                                201   6e-51
gi|109150416 peroxidasin [Homo sapiens]                               201   6e-51
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   199   2e-50
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   199   2e-50
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   199   2e-50
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]     197   9e-50
gi|7657361 contactin 6 [Homo sapiens]                                 189   2e-47
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  188   4e-47

>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score = 3271 bits (8480), Expect = 0.0
 Identities = 1606/1606 (100%), Positives = 1606/1606 (100%)

Query: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
            MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60

Query: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
            EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120

Query: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
            NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180

Query: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
            IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240

Query: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
            EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
            EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
            QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
            IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
            LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
            VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600

Query: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
            ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660

Query: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
            VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720

Query: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
            EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780

Query: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
            CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840

Query: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
            PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900

Query: 901  KVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN 960
            KVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN
Sbjct: 901  KVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN 960

Query: 961  LTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVN 1020
            LTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVN
Sbjct: 961  LTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVN 1020

Query: 1021 PSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKD 1080
            PSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKD
Sbjct: 1021 PSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKD 1080

Query: 1081 YRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL 1140
            YRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL
Sbjct: 1081 YRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL 1140

Query: 1141 LPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRG 1200
            LPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRG
Sbjct: 1141 LPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRG 1200

Query: 1201 AASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPI 1260
            AASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPI
Sbjct: 1201 AASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPI 1260

Query: 1261 SPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESS 1320
            SPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESS
Sbjct: 1261 SPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESS 1320

Query: 1321 VTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQD 1380
            VTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQD
Sbjct: 1321 VTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQD 1380

Query: 1381 AAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPV 1440
            AAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPV
Sbjct: 1381 AAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPV 1440

Query: 1441 PPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRT 1500
            PPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRT
Sbjct: 1441 PPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRT 1500

Query: 1501 NPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSS 1560
            NPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSS
Sbjct: 1501 NPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSS 1560

Query: 1561 SMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
            SMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1561 SMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
            sapiens]
          Length = 1615

 Score = 3258 bits (8447), Expect = 0.0
 Identities = 1604/1615 (99%), Positives = 1604/1615 (99%), Gaps = 9/1615 (0%)

Query: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
            MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60

Query: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
            EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120

Query: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
            NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180

Query: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
            IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240

Query: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
            EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
            EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
            QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
            IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
            LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
            VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600

Query: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
            ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660

Query: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
            VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720

Query: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
            EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780

Query: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
            CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840

Query: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
            PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900

Query: 901  K---------VTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 951
            K         VTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT
Sbjct: 901  KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 960

Query: 952  AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1011
            AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP
Sbjct: 961  AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1020

Query: 1012 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1071
            NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI
Sbjct: 1021 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1080

Query: 1072 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1131
            VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK
Sbjct: 1081 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1140

Query: 1132 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1191
            QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPAR YLQQDELEEEEDE
Sbjct: 1141 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDE 1200

Query: 1192 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1251
            RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV
Sbjct: 1201 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1260

Query: 1252 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1311
            SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA
Sbjct: 1261 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1320

Query: 1312 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1371
            SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL
Sbjct: 1321 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1380

Query: 1372 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1431
            KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY
Sbjct: 1381 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1440

Query: 1432 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1491
            TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVL 
Sbjct: 1441 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLG 1500

Query: 1492 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1551
            GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN
Sbjct: 1501 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1560

Query: 1552 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
            NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1561 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1615


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score = 3252 bits (8432), Expect = 0.0
 Identities = 1603/1615 (99%), Positives = 1603/1615 (99%), Gaps = 12/1615 (0%)

Query: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
            MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60

Query: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
            EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120

Query: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
            NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180

Query: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
            IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240

Query: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
            EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
            EASATLTVQ   EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301  EASATLTVQ---EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357

Query: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
            QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 358  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417

Query: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
            IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 418  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477

Query: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
            LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 478  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537

Query: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
            VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 538  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 597

Query: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
            ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 598  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 657

Query: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
            VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 658  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 717

Query: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
            EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 718  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777

Query: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
            CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 778  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 837

Query: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
            PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 838  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 897

Query: 901  KV---------TYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 951
            KV         TYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT
Sbjct: 898  KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 957

Query: 952  AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1011
            AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP
Sbjct: 958  AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1017

Query: 1012 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1071
            NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI
Sbjct: 1018 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1077

Query: 1072 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1131
            VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK
Sbjct: 1078 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1137

Query: 1132 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1191
            QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE
Sbjct: 1138 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1197

Query: 1192 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1251
            RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV
Sbjct: 1198 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1257

Query: 1252 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1311
            SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA
Sbjct: 1258 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1317

Query: 1312 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1371
            SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL
Sbjct: 1318 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1377

Query: 1372 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1431
            KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY
Sbjct: 1378 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1437

Query: 1432 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1491
            TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD
Sbjct: 1438 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1497

Query: 1492 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1551
            GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN
Sbjct: 1498 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1557

Query: 1552 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
            NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1558 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score = 3214 bits (8333), Expect = 0.0
 Identities = 1585/1598 (99%), Positives = 1586/1598 (99%), Gaps = 12/1598 (0%)

Query: 18   SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
            +GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR
Sbjct: 57   TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116

Query: 78   SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
            SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP
Sbjct: 117  SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176

Query: 138  SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
            SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG
Sbjct: 177  SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 236

Query: 198  KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
            KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR
Sbjct: 237  KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296

Query: 258  KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
            KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ   EPPHF
Sbjct: 297  KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ---EPPHF 353

Query: 318  VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
            VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL
Sbjct: 354  VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 413

Query: 378  TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
            TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV
Sbjct: 414  TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 473

Query: 438  LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
            LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE
Sbjct: 474  LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533

Query: 498  ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
            ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS
Sbjct: 534  ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 593

Query: 558  YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
            YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK
Sbjct: 594  YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 653

Query: 618  TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
            TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP
Sbjct: 654  TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 713

Query: 678  SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
            SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE
Sbjct: 714  SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 773

Query: 738  APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
            APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS
Sbjct: 774  APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 833

Query: 798  TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
            TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV
Sbjct: 834  TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 893

Query: 858  VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKV---------TYQRGG 908
            VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKV         TYQRGG
Sbjct: 894  VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG 953

Query: 909  EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 968
            EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA
Sbjct: 954  EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 1013

Query: 969  DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1028
            DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY
Sbjct: 1014 DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1073

Query: 1029 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1088
            ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP
Sbjct: 1074 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1133

Query: 1089 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1148
            PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP
Sbjct: 1134 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1193

Query: 1149 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1208
            PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV
Sbjct: 1194 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1253

Query: 1209 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1268
            SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY
Sbjct: 1254 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1313

Query: 1269 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1328
            ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING
Sbjct: 1314 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1373

Query: 1329 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1388
            WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH
Sbjct: 1374 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1433

Query: 1389 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1448
            ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP
Sbjct: 1434 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1493

Query: 1449 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1508
            TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA
Sbjct: 1494 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1553

Query: 1509 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1568
            QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG
Sbjct: 1554 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1613

Query: 1569 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
            SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1614 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1651


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score = 3111 bits (8065), Expect = 0.0
 Identities = 1543/1606 (96%), Positives = 1544/1606 (96%), Gaps = 55/1606 (3%)

Query: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
            MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60

Query: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
            EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120

Query: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
            NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180

Query: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
            IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240

Query: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
            EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
            EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
            QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
            IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
            LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
            VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600

Query: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
            ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660

Query: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
            VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720

Query: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
            EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780

Query: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
            CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840

Query: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
            PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900

Query: 901  KVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN 960
            KVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN
Sbjct: 901  KVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN 960

Query: 961  LTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVN 1020
            LTTYSRP                     + T Y    L                      
Sbjct: 961  LTTYSRPG--------------------QPTPYATTQL---------------------- 978

Query: 1021 PSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKD 1080
                         IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKD
Sbjct: 979  -------------IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKD 1025

Query: 1081 YRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL 1140
            YRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL
Sbjct: 1026 YRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL 1085

Query: 1141 LPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRG 1200
            LPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRG
Sbjct: 1086 LPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRG 1145

Query: 1201 AASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPI 1260
            AASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPI
Sbjct: 1146 AASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPI 1205

Query: 1261 SPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESS 1320
            SPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESS
Sbjct: 1206 SPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESS 1265

Query: 1321 VTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQD 1380
            VTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQD
Sbjct: 1266 VTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQD 1325

Query: 1381 AAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPV 1440
            AAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPV
Sbjct: 1326 AAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPV 1385

Query: 1441 PPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRT 1500
            PPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRT
Sbjct: 1386 PPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRT 1445

Query: 1501 NPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSS 1560
            NPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSS
Sbjct: 1446 NPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSS 1505

Query: 1561 SMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
            SMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1506 SMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1551


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
            sapiens]
          Length = 1562

 Score = 3102 bits (8042), Expect = 0.0
 Identities = 1543/1615 (95%), Positives = 1544/1615 (95%), Gaps = 62/1615 (3%)

Query: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
            MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1    MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60

Query: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
            EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61   EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120

Query: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
            NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121  NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180

Query: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
            IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181  IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240

Query: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
            EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241  EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300

Query: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
            EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301  EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360

Query: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
            QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361  QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420

Query: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
            IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480

Query: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
            LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540

Query: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
            VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600

Query: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
            ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660

Query: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
            VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720

Query: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
            EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780

Query: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
            CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781  CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840

Query: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
            PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841  PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900

Query: 901  K---------VTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 951
            K         VTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT
Sbjct: 901  KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 960

Query: 952  AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1011
            AGNGNSDSNLTTYSRPAD                   + T Y    L             
Sbjct: 961  AGNGNSDSNLTTYSRPADW------------------QPTPYATTQL------------- 989

Query: 1012 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1071
                                  IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI
Sbjct: 990  ----------------------IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1027

Query: 1072 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1131
            VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK
Sbjct: 1028 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1087

Query: 1132 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1191
            QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPAR YLQQDELEEEEDE
Sbjct: 1088 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDE 1147

Query: 1192 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1251
            RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV
Sbjct: 1148 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1207

Query: 1252 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1311
            SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA
Sbjct: 1208 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1267

Query: 1312 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1371
            SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL
Sbjct: 1268 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1327

Query: 1372 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1431
            KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY
Sbjct: 1328 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1387

Query: 1432 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1491
            TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVL 
Sbjct: 1388 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLG 1447

Query: 1492 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1551
            GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN
Sbjct: 1448 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1507

Query: 1552 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
            NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1508 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1562


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
            ROBO2a [Homo sapiens]
          Length = 1394

 Score = 1395 bits (3611), Expect = 0.0
 Identities = 762/1456 (52%), Positives = 949/1456 (65%), Gaps = 164/1456 (11%)

Query: 19   GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
            GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 37   GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 96

Query: 79   HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
            HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 97   HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 156

Query: 139  DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
            DV+VA GEPA++ECQPPRGHPEPTI WKKD   +DDK+ERI+IRGGKLMI+ TRKSDAG 
Sbjct: 157  DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 216

Query: 199  YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
            Y CVGTNMVGER+S+ AELTV ERP+F++RP N  V  +++ EF+C+ +GDP PTVRW+K
Sbjct: 217  YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 276

Query: 259  DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
            DD +LP+ RY+I+DD+TL+I+K  + D G+Y C+AEN VGK EASATLTV+    PP FV
Sbjct: 277  DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA---PPQFV 333

Query: 319  VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
            V+PRDQ+VA GRTVTF CE  GNPQPA+FW++EGSQNLLF  QP Q +SR SVS TGDLT
Sbjct: 334  VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 393

Query: 379  ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
            ITN+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L
Sbjct: 394  ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 453

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
             C ATG P+P I W K+G     +D R    E G LQI+  ++ DTG YTC+A++ SGE 
Sbjct: 454  KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 513

Query: 499  TWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY 558
            +WSA ++V E G  +   +  D + +P  PSKP+VTDV++N+VTLSWQP        ++Y
Sbjct: 514  SWSAVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAY 571

Query: 559  IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 618
            IIEAFS +  +SWQTVA +VKT    ++GL+PN IYLF+VRA N  G+SDPS +SDPV+T
Sbjct: 572  IIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT 631

Query: 619  QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 678
            QD+ P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 632  QDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQT 691

Query: 679  GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 738
                  S W   + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K  +T EEA
Sbjct: 692  SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 751

Query: 739  PSAPPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
            PSAPPQ VTV +    N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD +
Sbjct: 752  PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 811

Query: 798  TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
              SV+I  L PGI+Y VEVAAST AG GVKSEPQ I +      V  E+  S+ +QI+DV
Sbjct: 812  IRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDV 871

Query: 858  VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRG-GEAVSSGGR 916
            VKQPAFIAGIG ACW+ILM FSIWLY  RKKR GL S YA    VT+QRG G  +S+G R
Sbjct: 872  VKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA----VTFQRGDGGLMSNGSR 926

Query: 917  PGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNN 976
            PGLLN  +P + PWLAD+WP T               N NS  N        D +     
Sbjct: 927  PGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDVLPPVPG 975

Query: 977  QLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQS 1036
            Q D  +T  ML +  +Y  +D + K     ++NS         +   Q TPYATTQ++  
Sbjct: 976  QGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYATTQILH- 1020

Query: 1037 NLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQS 1096
              SN+++  + D  +  WK   QQK ++    Y++ +QNK                    
Sbjct: 1021 --SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------------- 1058

Query: 1097 YDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPPPHSNSE 1155
               N GG                 KK   + K  K  G  WA++ LPPPP  P P +  E
Sbjct: 1059 --GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELE 1104

Query: 1156 EYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSPAAVSYS 1211
             Y +   E+ YD +  CP  P + YL Q   DEL EE+D+R PTPPVRG ASSP A+S+ 
Sbjct: 1105 HYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP-AISFG 1162

Query: 1212 HQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSPPPPPRP 1259
             QSTATLTPSP+EE+QPMLQ            D  ++T H+Q       QP  PP PP  
Sbjct: 1163 QQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQPPVPP-- 1216

Query: 1260 ISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLES 1319
                   GY+SG L+SD++TD     +D+AD E   ++  R  LR L+QTP SS+ +L+S
Sbjct: 1217 ------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSSMDNLDS 1266

Query: 1320 SVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQ 1379
            SVTG               SS R   +S    F TD++ + A++                
Sbjct: 1267 SVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------------- 1296

Query: 1380 DAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYTDDLPPP 1438
                      SQ PRPT               K     ++  QP    RRE  TD+    
Sbjct: 1297 ---------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMTDEEALV 1332

Query: 1439 PVPPPAIKSPTAQSKT 1454
            P   P+  SP   S +
Sbjct: 1333 PYSKPSFPSPGGHSSS 1348



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)

Query: 1436 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1485
            P PPVPP           +++  A      E   + +P+ L ++D     S D   SS  
Sbjct: 1210 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1269

Query: 1486 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1537
            G+        R      T+        + Q     + +K  + D  PA  H       +E
Sbjct: 1270 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1329

Query: 1538 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1589
             ++PY +P+FP   +P   SSS + SS+GS G R+ E    G +RN +++  +G
Sbjct: 1330 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1380


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
            ROBO2b [Homo sapiens]
          Length = 1378

 Score = 1395 bits (3611), Expect = 0.0
 Identities = 762/1456 (52%), Positives = 949/1456 (65%), Gaps = 164/1456 (11%)

Query: 19   GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
            GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 21   GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80

Query: 79   HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
            HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 81   HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140

Query: 139  DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
            DV+VA GEPA++ECQPPRGHPEPTI WKKD   +DDK+ERI+IRGGKLMI+ TRKSDAG 
Sbjct: 141  DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200

Query: 199  YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
            Y CVGTNMVGER+S+ AELTV ERP+F++RP N  V  +++ EF+C+ +GDP PTVRW+K
Sbjct: 201  YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260

Query: 259  DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
            DD +LP+ RY+I+DD+TL+I+K  + D G+Y C+AEN VGK EASATLTV+    PP FV
Sbjct: 261  DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA---PPQFV 317

Query: 319  VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
            V+PRDQ+VA GRTVTF CE  GNPQPA+FW++EGSQNLLF  QP Q +SR SVS TGDLT
Sbjct: 318  VRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLT 377

Query: 379  ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
            ITN+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L
Sbjct: 378  ITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALL 437

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
             C ATG P+P I W K+G     +D R    E G LQI+  ++ DTG YTC+A++ SGE 
Sbjct: 438  KCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGET 497

Query: 499  TWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY 558
            +WSA ++V E G  +   +  D + +P  PSKP+VTDV++N+VTLSWQP        ++Y
Sbjct: 498  SWSAVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAY 555

Query: 559  IIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 618
            IIEAFS +  +SWQTVA +VKT    ++GL+PN IYLF+VRA N  G+SDPS +SDPV+T
Sbjct: 556  IIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRT 615

Query: 619  QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 678
            QD+ P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 616  QDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQT 675

Query: 679  GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 738
                  S W   + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K  +T EEA
Sbjct: 676  SGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEA 735

Query: 739  PSAPPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
            PSAPPQ VTV +    N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD +
Sbjct: 736  PSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAA 795

Query: 798  TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
              SV+I  L PGI+Y VEVAAST AG GVKSEPQ I +      V  E+  S+ +QI+DV
Sbjct: 796  IRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDV 855

Query: 858  VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRG-GEAVSSGGR 916
            VKQPAFIAGIG ACW+ILM FSIWLY  RKKR GL S YA    VT+QRG G  +S+G R
Sbjct: 856  VKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA----VTFQRGDGGLMSNGSR 910

Query: 917  PGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNN 976
            PGLLN  +P + PWLAD+WP T               N NS  N        D +     
Sbjct: 911  PGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDVLPPVPG 959

Query: 977  QLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQS 1036
            Q D  +T  ML +  +Y  +D + K     ++NS         +   Q TPYATTQ++  
Sbjct: 960  QGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYATTQILH- 1004

Query: 1037 NLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQS 1096
              SN+++  + D  +  WK   QQK ++    Y++ +QNK                    
Sbjct: 1005 --SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------------- 1042

Query: 1097 YDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPPPHSNSE 1155
               N GG                 KK   + K  K  G  WA++ LPPPP  P P +  E
Sbjct: 1043 --GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELE 1088

Query: 1156 EYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSPAAVSYS 1211
             Y +   E+ YD +  CP  P + YL Q   DEL EE+D+R PTPPVRG ASSP A+S+ 
Sbjct: 1089 HYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP-AISFG 1146

Query: 1212 HQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSPPPPPRP 1259
             QSTATLTPSP+EE+QPMLQ            D  ++T H+Q       QP  PP PP  
Sbjct: 1147 QQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQPPVPP-- 1200

Query: 1260 ISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLES 1319
                   GY+SG L+SD++TD     +D+AD E   ++  R  LR L+QTP SS+ +L+S
Sbjct: 1201 ------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSSMDNLDS 1250

Query: 1320 SVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQ 1379
            SVTG               SS R   +S    F TD++ + A++                
Sbjct: 1251 SVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------------- 1280

Query: 1380 DAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYTDDLPPP 1438
                      SQ PRPT               K     ++  QP    RRE  TD+    
Sbjct: 1281 ---------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMTDEEALV 1316

Query: 1439 PVPPPAIKSPTAQSKT 1454
            P   P+  SP   S +
Sbjct: 1317 PYSKPSFPSPGGHSSS 1332



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)

Query: 1436 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1485
            P PPVPP           +++  A      E   + +P+ L ++D     S D   SS  
Sbjct: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253

Query: 1486 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1537
            G+        R      T+        + Q     + +K  + D  PA  H       +E
Sbjct: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313

Query: 1538 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1589
             ++PY +P+FP   +P   SSS + SS+GS G R+ E    G +RN +++  +G
Sbjct: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
            sapiens]
          Length = 1386

 Score =  950 bits (2455), Expect = 0.0
 Identities = 548/1249 (43%), Positives = 741/1249 (59%), Gaps = 124/1249 (9%)

Query: 18   SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
            +GSR+  ED  PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR
Sbjct: 53   NGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPR 112

Query: 78   SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
            +HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 113  AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172

Query: 138  SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
             +V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 173  GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232

Query: 198  KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
             YVCV +NM GERES  AE+ VLERPSF++RP N  V  D    F CE +GDP P +RWR
Sbjct: 233  MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292

Query: 258  KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
            K+DGELP  RYEIR DH+L I  V+A D G+YTCVAEN VG+AEAS +L+V V   PP  
Sbjct: 293  KEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHV---PPQL 349

Query: 318  VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
            V +P+DQ+ A G +V FQCE  GNP PAIFW++EGSQ LLF  Q  Q + RFSVS  G L
Sbjct: 350  VTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQL 409

Query: 378  TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
             IT VQR D GYY+CQ ++VAGSI+ KA LE+     D  PPVI QGP NQT+ +  +  
Sbjct: 410  NITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVW 469

Query: 438  LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
            L C  TG+P P++ W+KDG  +   D + K + NG L I   +  D G Y+C+A + +GE
Sbjct: 470  LPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGE 529

Query: 498  ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
            ATWS +++++E    V P  PT+P+  P APS+P VT++++N++TL+W+PN  +GA  TS
Sbjct: 530  ATWSGWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTS 588

Query: 558  YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
            Y+IEAFS A+G++W+TVA+ V+ ET  + GL+PN IYLFLVRA  A+G+S+PS +S+PV+
Sbjct: 589  YVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVR 648

Query: 618  TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
            TQD  P+    D  + Q+ L    + L  P VL   +++V WTVD   Q +QG+++ +R 
Sbjct: 649  TQDSSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRV 708

Query: 678  SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
            +G   G   W + ++++P++ S V+  L  G   +IK +    E  GA+S        EE
Sbjct: 709  AGPEGG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEE 766

Query: 738  APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
            APS PPQGV V+      ++I VSW+PP    QNG++ EY++WCLGNE+R+H+N++  G 
Sbjct: 767  APSGPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGW 826

Query: 798  TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQIS 855
              S ++  LVPG+ Y   VAA+T AG GV S P  +QL +  + + P  E    LA +++
Sbjct: 827  ARSAMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLA 885

Query: 856  DVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGL---TSTYAGIRKVTYQRGGEAVS 912
             V+++PAF+AG GAAC  +L+     LY  RK+R  L   T+++A    V++        
Sbjct: 886  RVLREPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTASFAYTPAVSFPHSEGLSG 945

Query: 913  SGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLTTYSRPA 968
            +  RP  GL     PA   WLAD+WP+   + +  +   SCC +   N D +   Y+   
Sbjct: 946  ASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDRYYNE-- 996

Query: 969  DCIANYNNQLDNKQTNLMLP-ESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTP 1027
               A  +  L         P E  VY  +D + +  E++TF+      G   +PSG   P
Sbjct: 997  ---AGISLYLAQTARGTAAPGEGPVYSTIDPAGE--ELQTFHG-----GFPQHPSGDLGP 1046

Query: 1028 YATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTV 1087
            +  +Q      S       GDSG K     G+ K    PVQ        LN      + +
Sbjct: 1047 W--SQYAPPEWS------QGDSGAKG----GKVKLLGKPVQ-----MPSLNWP----EAL 1085

Query: 1088 PPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAH 1147
            PP  P               S   S   G +   +G+  P+        W   +P     
Sbjct: 1086 PPPPP---------------SCELSCLEGPEEELEGSSEPE-------EWCPPMPERSHL 1123

Query: 1148 PPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAA 1207
              P S+                 C V P+R            +   PTP           
Sbjct: 1124 TEPSSSG---------------GCLVTPSR-----------RETPSPTP----------- 1146

Query: 1208 VSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1256
             SY  QSTATLTPSP +  QP     P +  H+   P  RR P+ P  P
Sbjct: 1147 -SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)

Query: 1370 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1425
            G++ AR     A      H S  P P++  S          + T P +    + + +P  
Sbjct: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255

Query: 1426 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1483
            L  RRE    DLPPPP+PPP  ++  A     LE+R      + S++   +RS +RK   
Sbjct: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305

Query: 1484 YKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1543
                      Q V +                       AA+R L P      +E  LPY 
Sbjct: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327

Query: 1544 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1575
            RP+F           T+ +     SSSS  SRG G SR R Q+
Sbjct: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score =  234 bits (597), Expect = 5e-61
 Identities = 219/861 (25%), Positives = 358/861 (41%), Gaps = 88/861 (10%)

Query: 25   EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            ED  PRIV   S+ +V+ GE  +L C A+G P PT+ W    E +  D    R+++  + 
Sbjct: 464  EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMS 522

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----D 139
             G+      V G + R D GVY C ARN +G A  + A + V       R  PS     +
Sbjct: 523  DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRN 573

Query: 140  VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGK 198
            +    G   ++ C+   G+P  +I W KD   L D   ++    G L +T  +K  D G+
Sbjct: 574  ITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632

Query: 199  YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWR 257
            Y+C          S+   + V + P  ++       ++       C      +P  + WR
Sbjct: 633  YLCSVLIQPQLSISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691

Query: 258  KDDGELPKSRYEIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
            KD G++  S   +  +      +L+I  V+    G+YTC+A N          L V+V  
Sbjct: 692  KD-GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV-- 748

Query: 313  EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
             PP FVV+P +Q    G+     C   G P P + W+          Y P   + R  + 
Sbjct: 749  -PPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQIL 807

Query: 373  QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
                L I +V   D+GYY+CQ  N  G+ I+K+      +     P +I   P N T+A+
Sbjct: 808  PNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAI 861

Query: 433  DG-TFVLSCVATGSPVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGD 483
             G    L+C A G     I W K   ++         I   +NG      L+++ A  GD
Sbjct: 862  KGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGD 921

Query: 484  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
            +  ++C A    GE      + VQE                P  P + E+ +V   ++ L
Sbjct: 922  SVFFSCHAINSYGEDRGLIQLTVQE----------------PPDPPELEIREVKARSMNL 965

Query: 544  SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAA 601
             W    +  +  T + IE  + +    ++    N+      + I  L P ++Y   + + 
Sbjct: 966  RWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSF 1025

Query: 602  NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 661
            N  G S+PS+    + T++  P    +D                    ++S SI+V W  
Sbjct: 1026 NKIGRSEPSK-ELTISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKA 1069

Query: 662  ---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 717
               + Q+  I+GY+I YR +        + + E++    + V  + +L+K   Y +  + 
Sbjct: 1070 PKKELQNGVIRGYQIGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128

Query: 718  FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
            F     G  S    A TLE+ PS PP+ V       +    ++SW  PP  T NG+++ Y
Sbjct: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGY 1186

Query: 778  KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 835
            +V  W L  +  +   + +  +   V +  +     YSV+V A T AG GV+S   +IQ 
Sbjct: 1187 RVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246

Query: 836  --DAHGNPVSPEDQVSLAQQI 854
              D  G P   +   S A  +
Sbjct: 1247 KEDVPGPPAGIKAVPSSASSV 1267



 Score =  139 bits (349), Expect = 3e-32
 Identities = 144/491 (29%), Positives = 204/491 (41%), Gaps = 71/491 (14%)

Query: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
           P I++      V  G    L C A G P P I W K G                LP+ S 
Sbjct: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331

Query: 89  FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
           +  RI     S     D G Y+C   N  G A +    + +  L       P  +   +G
Sbjct: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389

Query: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 202
              ++ C    G PE TI W ++ + L   DE I+IRG     L+IT  +KS +G Y C 
Sbjct: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447

Query: 203 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
            T     R+++ A+   +  LE   P  V   S   V   +     C A+G P PTV W 
Sbjct: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502

Query: 258 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 308
            D      DG    ++Y + D  T+    VT     D G Y C A N+VG AE  A + V
Sbjct: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562

Query: 309 QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
           +     P  +   R+     GR     C   G P  +I W ++    LL        + R
Sbjct: 563 R----GPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHR 610

Query: 369 FSVSQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGP 425
             V + G L +T+VQ+  D G Y+C       S++ +  L ++    +A + PP+I+  P
Sbjct: 611 QVVFENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--P 661

Query: 426 VNQTVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKL 481
                A  G  + + CV +   +P  I WRKDG V++S     I+  E    LQI    L
Sbjct: 662 FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721

Query: 482 GDTGRYTCIAS 492
              G YTCIAS
Sbjct: 722 KHNGNYTCIAS 732



 Score =  135 bits (341), Expect = 2e-31
 Identities = 201/863 (23%), Positives = 321/863 (37%), Gaps = 103/863 (11%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            P  +   P  L    G    L+C   G P  TI WY+  E V  D+       + +   S
Sbjct: 374  PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE------AISIRGLS 427

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD---FRQNPSDVMVAV 144
               L I   +KS    G Y C A      A        +  L D       + S+ +V  
Sbjct: 428  NETLLITSAQKSH--SGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481

Query: 145  GEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGG----KLMITYTRKSDA 196
            GE   + C   +G P PT++W  D  P+      +  + T+  G     + +T  +  D 
Sbjct: 482  GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540

Query: 197  GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
            G Y C   N+VG  E + A + V   PS ++   N+           C   G P  +++W
Sbjct: 541  GVYRCTARNLVGSAEYQ-ARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598

Query: 257  RKDDGELPKS-RYEIRDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSEP 314
             KD   LP + R  + ++ TLK+  V  G D G Y C   +++ + + S + +V V  + 
Sbjct: 599  YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---SVLIQPQLSISQSVHVAVKV 655

Query: 315  PHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
            P  +        ++G+ +   C  +    P  I WR++G   +  S    +S    S   
Sbjct: 656  PPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS--- 712

Query: 374  TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
               L I++V     G Y C   N A ++  +  L V      R PP     P NQ     
Sbjct: 713  --SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYG 764

Query: 434  GTFVLSCVATGSPVPTILWRKDGVLVSTQD-------SRIKQLENGVLQIRYAKLGDTGR 486
               VL+C   G P P ++W+      + Q         RI+ L N  L IR+    D G 
Sbjct: 765  KAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGY 824

Query: 487  YTCIASTPSG-EATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
            Y C AS   G + + S ++ V+   +P      P     I     +   T      + + 
Sbjct: 825  YLCQASNGVGTDISKSMFLTVK---IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR 881

Query: 545  WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY 604
            W+   ++   P    +  ++ A+  +   V   +K     +K         F   A N+Y
Sbjct: 882  WEKG-DTVIDPDR--VMRYAIATKDNGDEVVSTLK-----LKPADRGDSVFFSCHAINSY 933

Query: 605  GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-Q 663
            G                    +G+    VQ       L +     + + S+ + WT    
Sbjct: 934  G------------------EDRGLIQLTVQEPPDPPELEIRE---VKARSMNLRWTQRFD 972

Query: 664  QSQYIQGYKILYRPSGANHGESDWLVFEVRT----PAKNSVVIPDLRKGVNYEIKARPFF 719
             +  I G+ I Y+       +SD   F+  T    P  N   I DL     Y I+   F 
Sbjct: 973  GNSIITGFDIEYK------NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026

Query: 720  NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
               +   S+     T E AP  PP  VT+        +I V+W+ P ++ QNG+++ Y++
Sbjct: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKAPKKELQNGVIRGYQI 1084

Query: 780  W----CLGNETRYHI-NKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
                   G+  +Y I      G +    +  L    +Y V V A   AG+G  S  +   
Sbjct: 1085 GYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINA 1143

Query: 835  LDAHGNPVSPEDQVSLAQQISDV 857
                  P  P + V      SDV
Sbjct: 1144 TTLEDVPSQPPENVRALSITSDV 1166



 Score =  129 bits (323), Expect = 3e-29
 Identities = 186/836 (22%), Positives = 323/836 (38%), Gaps = 115/836 (13%)

Query: 43   GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 101
            G    +NC+  G P  +I+WYK    +      P +HR ++  +G+L    +  G     
Sbjct: 579  GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628

Query: 102  DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
            DEG Y+C  + +  L  + S + +++V  L   F   P+    ++G+   + C    G  
Sbjct: 629  DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684

Query: 160  EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 215
               I+W+KDG  +      +TI   + M    I+       G Y C+ +N       E  
Sbjct: 685  PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742

Query: 216  ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 268
            +L V   P FV +P+N       +    C   G P P V W+   G     +Y       
Sbjct: 743  QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802

Query: 269  --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQVGSEPPHFVVKPRDQV 325
              +I  + +L IR V   D+G Y C A N VG     S  LTV++   P      P   +
Sbjct: 803  RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI---PAMITSHPNTTI 859

Query: 326  VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ 383
               G      C A G     I W +  +         P    R++++    GD  ++ ++
Sbjct: 860  AIKGHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLK 913

Query: 384  -----RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAV 432
                 R D  ++ C  +N  G    +  +++T      PP +       R   +  T   
Sbjct: 914  LKPADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRF 971

Query: 433  DGTFVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRY 487
            DG  +++         +  W        +  +   + I  L    V  IR       GR 
Sbjct: 972  DGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR- 1030

Query: 488  TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 547
                S PS E T S      E   P  PP   D  L P          V+  ++ ++W+ 
Sbjct: 1031 ----SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKA 1069

Query: 548  ---NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRA 600
                L +G     Y I    ++ GS+ Q     +K    +E   +  LK  A Y  +V+A
Sbjct: 1070 PKKELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128

Query: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
             N  G    S   +    +DV P+    + + +      AV+    P   + + +     
Sbjct: 1129 FNRAGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV----- 1182

Query: 661  VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
                   ++GY++++    + + + +W   +  T  +  V +  + K  NY ++   +  
Sbjct: 1183 -------LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQ 1232

Query: 721  EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
               G  S + + +T E+ P  PP G+    +  + ++++VSW PP +   NG++++Y ++
Sbjct: 1233 AGDGVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIF 1287

Query: 781  CLGNETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 834
            C    +        + S   +   I  L  G +Y + VAA T AG G  SE   I+
Sbjct: 1288 CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343



 Score =  126 bits (317), Expect = 1e-28
 Identities = 133/480 (27%), Positives = 193/480 (40%), Gaps = 45/480 (9%)

Query: 50  CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 104
           C A G P+  + WY   G+ +         H      L P     F   +H       + 
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159

Query: 105 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 162
            Y C A N  G+  S N  ++ A+ R+ +     D     G  AV +C  P    E    
Sbjct: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218

Query: 163 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 218
           +SW+KD  S + +    IT  GG L I+  +K DA   Y C+  +   GE R+S  A L+
Sbjct: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277

Query: 219 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 274
           V +     P+ +    +  V    + E  C A G P+P +RW KD   LP      +   
Sbjct: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337

Query: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
            L I  +   D G+Y C   N  G AEA+  L V    +P H  + P+     +G TV  
Sbjct: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMV---IDPLHVTLTPKKLKTGIGSTVIL 394

Query: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394
            C  TG+P+  I W R     L     P ++ S   +S    L IT+ Q+S  G Y C  
Sbjct: 395 SCALTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFA 448

Query: 395 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR- 453
              A +    A + + D       P I      + V     F L C A G+P PT+ W  
Sbjct: 449 TRKAQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWAL 503

Query: 454 KDGVLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
            D  +V     R  Q  + +G     + +   ++ D G Y C A    G A + A I V+
Sbjct: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 26/324 (8%)

Query: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 255
           Y C   N  G+  S    +  + R  +  R  +      + A FKC    +  + V  V 
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220

Query: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQV 310
           W KD   + P+ R+ I     L I  V   D + +Y C+ ++      +    A L+V  
Sbjct: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280

Query: 311 GSEP-PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
            +E  P  +     Q V  G TV   C A+G P PAI W ++G        +P  + SR+
Sbjct: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332

Query: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
           +   TG LTI++++  D G YIC+  N  GS      L V D      P  +   P    
Sbjct: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385

Query: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 488
             +  T +LSC  TGSP  TI W ++  LV   ++  I+ L N  L I  A+   +G Y 
Sbjct: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445

Query: 489 CIASTPSGEATWSAYIEVQEFGVP 512
           C A+  +  A   A I +++ G P
Sbjct: 446 CFATRKAQTAQDFAIIALED-GTP 468



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)

Query: 438  LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
            L C + G P P + W KD     + VS    R+    NG L +R  K  D+G YTC A+ 
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427

Query: 494  PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
              G  T    + VQ   VP   PR T             V+  S +++TL+W P  N G+
Sbjct: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471

Query: 554  TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
            +   ++++ +S  +   W+ V  +    +  +  LK    Y   + A N+ G    S+I 
Sbjct: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530

Query: 614  DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
            +  KT    P+     H        +A L+L              W  +     I    +
Sbjct: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575

Query: 674  LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
             YRP G       W    +R  +   V + +LR+   YE++ R   N     +   +FA 
Sbjct: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628

Query: 734  TLEEAPSAPP 743
               +  + PP
Sbjct: 1629 LDYDGSTIPP 1638



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 244  CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 298
            C + GDP P V+W KD  D  +P S    R  HT   L +R V A D G YTC A N  G
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430

Query: 299  KAEASATLTVQVGSEPPHFVV 319
                   L VQV  + P   V
Sbjct: 1431 FDTIIVNLLVQVPPDQPRLTV 1451



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 72/362 (19%), Positives = 128/362 (35%), Gaps = 54/362 (14%)

Query: 261  GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
            G+   S YE   +    +I  +  G        A    G+  +S  +T++   + P    
Sbjct: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA--- 1350

Query: 320  KPRDQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
                ++++ G TVT          C + G+P PA+ W ++   + +    P        +
Sbjct: 1351 ----KIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLI 1402

Query: 372  SQTGDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
               G L +  V+  D GYY C   N  G  +II    ++V     D+P   + +   +  
Sbjct: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSI 1459

Query: 430  VAV------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
                      G+ +   V   S   +  W+   V +S+ +   K        +   K G 
Sbjct: 1460 TLTWIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGT 1509

Query: 484  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
              +    A    G    S  IE +  G   +P    D +L          T ++     L
Sbjct: 1510 WYKVKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARL 1558

Query: 544  SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 603
            + Q   N+G  P + I+  +      +WQ +  N   E   +  L+    Y   +RA N+
Sbjct: 1559 NLQ-GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNS 1616

Query: 604  YG 605
             G
Sbjct: 1617 AG 1618



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 36/171 (21%), Positives = 62/171 (36%), Gaps = 14/171 (8%)

Query: 157  GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
            G P P + W KD      P+     R+    G L++   +  D+G Y C  TN  G  ++
Sbjct: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433

Query: 213  EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
             +  L V   P   +        S++ +T           RG     +++  D+ E  K 
Sbjct: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490

Query: 267  RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
             +    + + K+  +  G        A+N VG    S  +  +     P F
Sbjct: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSF 1541



 Score = 34.7 bits (78), Expect = 0.76
 Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 84
            P +I+     +     +   L C + G P P ++W K  E    D   P S   HR++  
Sbjct: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARN 112
            +G+L  LR V       D G Y C A N
Sbjct: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score =  226 bits (577), Expect = 1e-58
 Identities = 259/974 (26%), Positives = 403/974 (41%), Gaps = 135/974 (13%)

Query: 25   EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 80
            ED  P+I+   S+ +VS  EP +L C  +G P PTI W        T  DDP     SHR
Sbjct: 403  EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454

Query: 81   ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
               M+   G++     +   + R D GVY C A N  G  V + A + V   R      P
Sbjct: 455  ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509

Query: 138  SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 194
               + A+ G    + C+   G+P  +I W K+ + L     ++     G L ++  +K  
Sbjct: 510  MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568

Query: 195  DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 253
            D G+Y C          S+   +TV + P F++       ++       C      +P T
Sbjct: 569  DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627

Query: 254  VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
            + W+KD   +P S     D+     +L+I  ++    G+YTC+A N     E  + L V+
Sbjct: 628  ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687

Query: 310  VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
            V   PP FVV+PRDQ    G+ V   C A G P P I W+      +   +QP   + R 
Sbjct: 688  V---PPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRI 743

Query: 370  SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQ 428
             V   G L I +V   D GYY+C+  N  G+ ++K+ YL V      + P +I   P N 
Sbjct: 744  QVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NT 796

Query: 429  TVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAK 480
            T+A  G    +SC A G     + W K+  +++ + +R  +   E G      LQI    
Sbjct: 797  TLATQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTV 856

Query: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
              D+G ++C A    GE      + VQE                P  P + E+ DV   T
Sbjct: 857  REDSGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKART 900

Query: 541  VTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLV 598
            +TL W    +  +  T Y IE  + +    S+ +T   + +  ++ I  + P++ Y   +
Sbjct: 901  ITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRM 960

Query: 599  RAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVH 658
             A N  G S+PS     +   +  P     +            +HL     +SS SI V 
Sbjct: 961  YAKNRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVT 1004

Query: 659  WTVDQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIK 714
            W   +   Q+  I+GY+I YR      G   + +  V T   + V  + +L K   Y + 
Sbjct: 1005 WKAPKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLV 1063

Query: 715  ARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMV 774
             +       G  S+     TLE+ PS PP+ V       +  +I +SW    ++  NG++
Sbjct: 1064 VQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGIL 1121

Query: 775  QEYKV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQF 832
            Q ++V  W    +      K +  +  S+ +  L     YS++V A T AG GV+SE  F
Sbjct: 1122 QGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIF 1181

Query: 833  IQL--DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRN 890
             +   D  G P                       AG+ AA     MVF  WL     K N
Sbjct: 1182 TRTKEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLN 1216

Query: 891  GLTSTYAGIRKVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNN--HNDCSIS 948
            G+      IRK T         S   P +++  E A+    +   PN   N  ++   ++
Sbjct: 1217 GI------IRKYT------VFCSHPYPTVISEFE-ASPDSFSYRIPNLSRNRQYSVWVVA 1263

Query: 949  CCTAGNGNSDSNLT 962
              +AG GNS   +T
Sbjct: 1264 VTSAGRGNSSEIIT 1277



 Score =  131 bits (330), Expect = 5e-30
 Identities = 192/855 (22%), Positives = 339/855 (39%), Gaps = 106/855 (12%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            P +    P  +  S G   +L+C   G     + WY+ GE +   K+        +    
Sbjct: 313  PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 144
            +    ++     + D G Y C  R    + +S    ++V +L D         S+ +V+ 
Sbjct: 365  INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420

Query: 145  GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 196
             EP  + C   +G P PTI+W  D  P+         + IT  G     L I+ ++  D 
Sbjct: 421  AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479

Query: 197  GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
            G Y C   N  G    + A + V   P+ ++   N+           C   G P  +++W
Sbjct: 480  GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537

Query: 257  RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTCVAENMVGKAEASATLTVQVGSE 313
             K+   LP +  ++   ++ TLK+  V    D G YTC   N++ + + S + +V V  +
Sbjct: 538  YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTC---NVLVQPQLSTSQSVHVTVK 594

Query: 314  PPHFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVS 372
             P F+        ++G+ V   C       P  I W+++G        +P   S   ++ 
Sbjct: 595  VPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTID 646

Query: 373  Q---TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
                T  L I+N+     G Y C   N A ++  ++ L V      R PP     P +Q 
Sbjct: 647  NIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQD 700

Query: 430  VAVDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGD 483
                   +L+C A G PVPTI+W+  K   +   Q    + RI+ L NG L I++    D
Sbjct: 701  GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEED 760

Query: 484  TGRYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNT 540
            +G Y C  S   G + + S Y+ V+   +    P  T    + +   K E+  T      
Sbjct: 761  SGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKP 816

Query: 541  VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
            + + W+            II         S + V E V +    +  ++ ++ + F   A
Sbjct: 817  IIVRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHA 867

Query: 601  ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
             N+YG                    +G+    VQ       + + +   + + +I + WT
Sbjct: 868  INSYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWT 906

Query: 661  VD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
            +    +  I GY I  + + ++  +S     +V +P  NS  I D+     Y I+     
Sbjct: 907  MGFDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-K 963

Query: 720  NEFQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYK 778
            N    ++   +   T +E AP  PPQ V +     +  +I V+W+ P +  QNG+++ Y+
Sbjct: 964  NRIGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQ 1021

Query: 779  V----WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 833
            +    +  G   +++ I+    G +    +  L    +Y + V A   AG+G  S+ + I
Sbjct: 1022 IGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EII 1080

Query: 834  QLDAHGNPVSPEDQV 848
                   P  P + V
Sbjct: 1081 TTTLEDVPSYPPENV 1095



 Score =  117 bits (293), Expect = 9e-26
 Identities = 129/490 (26%), Positives = 194/490 (39%), Gaps = 65/490 (13%)

Query: 50  CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 100
           C A G P  T+ WY   GE +     D    R + P+G+L         F  ++H     
Sbjct: 46  CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96

Query: 101 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 160
             +  Y C A N  G+  S +  ++ A+LR+ +     D     G  AV +C  P     
Sbjct: 97  --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153

Query: 161 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTN-MVGE-RESEVA 215
               +SW+KD   L      +    G L I   +  D    Y C+  +   GE R+S  A
Sbjct: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213

Query: 216 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 264
            L       FV  P+N A ++ D             E  C+A G P P  RW KD+  L 
Sbjct: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266

Query: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
            S    +    L I  +   D GSY C   N  G A+    L V+   +P    + PR  
Sbjct: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVK---QPLKATISPRKV 323

Query: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384
             ++G  V+  C  TG     + W R G          P  + R +     +L + ++ +
Sbjct: 324 KSSVGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVK 377

Query: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG 444
           SD G Y C        +  + Y++V  V+ D  P +I      + V+      L C   G
Sbjct: 378 SDGGAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKG 432

Query: 445 SPVPTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGE 497
           +P+PTI W   D  ++     RI Q+   E  V   L I  +++ D G Y C A+  +G 
Sbjct: 433 TPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492

Query: 498 ATWSAYIEVQ 507
             + A I V+
Sbjct: 493 VLYQARINVR 502



 Score =  103 bits (258), Expect = 1e-21
 Identities = 126/493 (25%), Positives = 188/493 (38%), Gaps = 46/493 (9%)

Query: 43  GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
           G+   L CKA G P P   W K    +E      ++   LL         I + R S  D
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287

Query: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
            G YVC   N  G A           L+     +P  V  +VG    + C    G  +  
Sbjct: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344

Query: 163 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
           +SW ++G  L+  K+ RIT I    L++ +  KSD G Y C         +  V  +   
Sbjct: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404

Query: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 275
             P  +   S   V+  +     C  +G P+PT+ W  DD  + K   + I    T    
Sbjct: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464

Query: 276 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVAL-GR 330
               L I      D G Y C A N  G     A + V+  +      ++P   + A+ GR
Sbjct: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS-----IRPMKNITAIAGR 519

Query: 331 TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGY 389
                C   G P  +I W +  + NLL     P +  + +    G L +++VQ+  D G 
Sbjct: 520 DTYIHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGE 572

Query: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 449
           Y C  L V   + T   + VT  +    PP I+     +       F+   V +G    T
Sbjct: 573 YTCNVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627

Query: 450 ILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
           I W+KDG  +  +    I  ++    L+I    L   G YTCIA   +      + + V+
Sbjct: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687

Query: 508 EFGVPVQPPRPTD 520
                V  PR  D
Sbjct: 688 VPPKFVVQPRDQD 700



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 121/465 (26%), Positives = 188/465 (40%), Gaps = 55/465 (11%)

Query: 83  LPSGSLFFLR---IVHGRKSRPDEGVYV--CVARN-YLGEAVSHNASLEVAILRDDFRQN 136
           L SGS F +     ++ +  + ++G+Y   C+ R+ Y GE    N++     + D     
Sbjct: 167 LVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSAR--LFVSDPANSA 224

Query: 137 PSDV------MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMIT 189
           PS +          G+   + C+   GHPEP   W KD  PL+     + T+ G  L+I 
Sbjct: 225 PSILDGFDHRKAMAGQRVELPCKA-LGHPEPDYRWLKDNMPLELSGRFQKTVTG--LLIE 281

Query: 190 YTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGD 249
             R SD+G YVC  +N  G  +  +  L V +       P  +  +V       C   G 
Sbjct: 282 NIRPSDSGSYVCEVSNRYGTAK-VIGRLYVKQPLKATISPRKVKSSVGSQVSLSCSVTGT 340

Query: 250 PVPTVRWRKDDGELPKSRYEIR----DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 305
               + W + +GE+      +R    +   L +  +   D G+Y C     V K + SA 
Sbjct: 341 EDQELSWYR-NGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC----FVRKDKLSAQ 395

Query: 306 LTVQVGSE--PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
             VQV  E   P  +    ++VV+    V+  C   G P P I W  +    L       
Sbjct: 396 DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPIL------K 449

Query: 364 QSSSRFSVSQTGD------LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
             S R S   T +      L I++ Q  D G Y C   N AG ++ +A + V      R 
Sbjct: 450 GGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINV------RG 503

Query: 418 PPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 476
           P  IR  P+    A+ G    + C   G P  +I W K+  L+     ++    NG L++
Sbjct: 504 PASIR--PMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKL 561

Query: 477 R-YAKLGDTGRYTC-IASTPSGEATWSAY--IEVQEFGVPVQPPR 517
               K  D G YTC +   P    + S +  ++V  F  P + PR
Sbjct: 562 SDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPR 606



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)

Query: 437  VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
            VL C A G P P + W KD      + T D R     NG   IR  K  D+G Y+CIA+ 
Sbjct: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363

Query: 494  PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
              G       ++VQ   VP   PR T             V+  + +++TLSW P  N G+
Sbjct: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407

Query: 554  TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 613
            +   YI++ +S  +   W +   +    +  ++ LK    Y F + A N  G   P +IS
Sbjct: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463

Query: 614  DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 673
            + ++ + +    Q    +++   +    + L+           + W  +     I  + +
Sbjct: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511

Query: 674  LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
             YRP     G + W   + RT    S ++ DL++   YE++ R   N    A+ +  FA 
Sbjct: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565

Query: 734  TLEEAPSAPPQGVTVSKND 752
               +  + PP   +V +N+
Sbjct: 1566 LNYDGSTIPPLIKSVVQNE 1584



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 31/81 (38%), Positives = 38/81 (46%), Gaps = 5/81 (6%)

Query: 244  CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
            C+A GDP P V+W KD    P       R  I  + +  IR V A D G Y+C+A N  G
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366

Query: 299  KAEASATLTVQVGSEPPHFVV 319
              E    L VQV  + P   V
Sbjct: 1367 SDEIILNLQVQVPPDQPRLTV 1387



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 79/383 (20%), Positives = 144/383 (37%), Gaps = 57/383 (14%)

Query: 272  DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALG-R 330
            D  + +I  ++     S   VA    G+  +S  +TV+  ++ P  ++     V     +
Sbjct: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPARILTFSGTVTTPWMK 1301

Query: 331  TVTFQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 388
             +   C+A G+P PA+ W ++  G+ +L+          R S+   G   I  V+  D G
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKAEDSG 1355

Query: 389  YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFVLSCV 441
            YY C   N  GS      L+V  V  D+P   + +   + ++ +        G+ +   +
Sbjct: 1356 YYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSIRGYI 1413

Query: 442  ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501
               S   +  W    +  S +  R++ L          K G   ++T  A    G    S
Sbjct: 1414 LQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGPGRIS 1463

Query: 502  AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-TSYII 560
              IE +  G   +P    +  L  S       T V  N +   W    N G  P TS+ +
Sbjct: 1464 EIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPITSFTL 1511

Query: 561  EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD------------ 608
            E +     + W T      +++  +  L+    Y   +R  N+ G ++            
Sbjct: 1512 E-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG 1570

Query: 609  ---PSQISDPVKTQDVLPTSQGV 628
               P  I   V+ ++ L T++G+
Sbjct: 1571 STIPPLIKSVVQNEEGLTTNEGL 1593



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 37/171 (21%), Positives = 66/171 (38%), Gaps = 14/171 (8%)

Query: 157  GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
            G P P + W KD  G+P  +     R     G  +I   +  D+G Y C+  N  G  E 
Sbjct: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370

Query: 213  EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 266
             +  L V   P      V + ++ ++T+            RG     +++ +D+ E   S
Sbjct: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426

Query: 267  RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
                  + + ++  +  G    +T  A+N VG    S  +  +   + P F
Sbjct: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477



 Score = 35.0 bits (79), Expect = 0.58
 Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 85
            P RI+     +     +   L CKA G P+P ++W K   G       D  RS   +  +
Sbjct: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
            GS F +R V       D G Y C+A N  G
Sbjct: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  218 bits (555), Expect = 4e-56
 Identities = 171/562 (30%), Positives = 245/562 (43%), Gaps = 36/562 (6%)

Query: 24   QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
            Q   PP I   P+++ V      TL C+A G P P+I W K G  +  D++   S+R LL
Sbjct: 3799 QVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ-NSYR-LL 3856

Query: 84   PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
             SGSL  +       S  D   Y C   N  G+       L V +        P+D +V 
Sbjct: 3857 SSGSLVIIS-----PSVDDTATYECTVTNGAGDD-KRTVDLTVQV-PPSIADEPTDFLVT 3909

Query: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCV 202
               PAV+ C    G P P+I W K+G  L  + +   I   G + I  T+ + AG+Y CV
Sbjct: 3910 KHAPAVITCTAS-GVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968

Query: 203  GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
              N  G     V  L V E P    +PS L V +++     CEA G P P + W+K+   
Sbjct: 3969 ARNAAGSAHRHVT-LHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGIN 4027

Query: 263  LPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK 320
            +  S   + +     L+I +    D G+Y CVA+N  G A     L VQV   PP     
Sbjct: 4028 VNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQV---PPVISPH 4084

Query: 321  PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 380
             ++ V+A+ + +T  CEA G P P I W ++G   +         S R  V  +G L I 
Sbjct: 4085 LKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIV--------ESIRQRVLSSGSLQIA 4136

Query: 381  NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 440
             VQ  D G+Y C   NVAGS  T   L V        PP IR    + TV  +   +L C
Sbjct: 4137 FVQPGDAGHYTCMAANVAGSSSTSTKLTV------HVPPRIRSTEGHYTVNENSQAILPC 4190

Query: 441  VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 500
            VA G P P I W+KD VL++    +      G L +    L D+G YTC+A+  +GE T 
Sbjct: 4191 VADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTH 4250

Query: 501  SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL-----NSGATP 555
            +  + V       + P     N         + T +    +T ++  N+     +S    
Sbjct: 4251 TVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGH 4310

Query: 556  TSYIIEAFSHASGSSWQTVAEN 577
            +  +IE  S     ++   AEN
Sbjct: 4311 SELVIERVSKEDSGTYVCTAEN 4332



 Score =  209 bits (533), Expect = 1e-53
 Identities = 147/487 (30%), Positives = 221/487 (45%), Gaps = 36/487 (7%)

Query: 28   PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I   + P D+ V +    TL CK++  P P I W + GER++       + R+ + S
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQA------TPRVRILS 3672

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
            G  + L+I        D   Y CVA N  G+       +    +  + +  P  +++ + 
Sbjct: 3673 GGRY-LQI--NNADLGDTANYTCVASNIAGKTTRE--FILTVNVPPNIKGGPQSLVILLN 3727

Query: 146  EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCVGT 204
            +  V+EC    G P P I+W+KDG+ L     R +I   G L I     +D G+Y+C+ T
Sbjct: 3728 KSTVLECIA-EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMAT 3786

Query: 205  NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
            N  G     + +L V   PS    P+N+ V V+      CEA G P P++ WRK+   L 
Sbjct: 3787 NAAGTDRRRI-DLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN 3845

Query: 265  ----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK 320
                ++ Y +    +L I   +  D  +Y C   N  G  + +  LTVQV   PP    +
Sbjct: 3846 VDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQV---PPSIADE 3902

Query: 321  PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 380
            P D +V         C A+G P P+I W + G + L      P+    + +  +G + I 
Sbjct: 3903 PTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLL------PRGDG-YRILSSGAIEIL 3955

Query: 381  NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 440
              Q +  G Y C   N AGS      L V +      PPVI+  P    V ++   +L C
Sbjct: 3956 ATQLNHAGRYTCVARNAAGSAHRHVTLHVHE------PPVIQPQPSELHVILNNPILLPC 4009

Query: 441  VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 500
             ATG+P P I W+K+G+ V+T       L +G LQI  A   D G Y C+A  P+G A  
Sbjct: 4010 EATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG 4069

Query: 501  SAYIEVQ 507
               + VQ
Sbjct: 4070 KIKLNVQ 4076



 Score =  209 bits (531), Expect = 2e-53
 Identities = 159/522 (30%), Positives = 232/522 (44%), Gaps = 41/522 (7%)

Query: 48   LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYV 107
            + C+A G P P I W K G  +        SH  LL +G +  +RIV  + S  D  VY 
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLS-----SHIRLLAAGQV--IRIVRAQVS--DVAVYT 3412

Query: 108  CVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK 167
            CVA N  G    H      A    D      ++ V  G    M C    G P P+++W +
Sbjct: 3413 CVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITD-GTPAPSMAWLR 3471

Query: 168  DGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF- 225
            DG PL  D    ++  G  L +      D+GKY C+ +N  GE       L VLE P   
Sbjct: 3472 DGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFI-LKVLEPPHIN 3530

Query: 226  -VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY--EIRDDHTLKIRKVT 282
              +    ++V V++  E  C A G P P + W KD   LP++     +     L+I    
Sbjct: 3531 GSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQ 3590

Query: 283  AGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV--KPRDQVVALGRTVTFQCEATG 340
              D G YTC+A +  G  +    + V V   PP+     +PRD  V   R VT +C++  
Sbjct: 3591 VEDTGRYTCLASSPAGDDDKEYLVRVHV---PPNIAGTDEPRDITVLRNRQVTLECKSDA 3647

Query: 341  NPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAG 399
             P P I W R G +         Q++ R  +   G  L I N    D   Y C   N+AG
Sbjct: 3648 VPPPVITWLRNGERL--------QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAG 3699

Query: 400  SIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLV 459
               T+ ++   +V     PP I+ GP +  + ++ + VL C+A G P P I WRKDG ++
Sbjct: 3700 KT-TREFILTVNV-----PPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVL 3753

Query: 460  STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 519
            +   +R   LENG L I+ A + DTGRY C+A+  +G  T    I++Q    P   P PT
Sbjct: 3754 AGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAG--TDRRRIDLQVHVPPSIAPGPT 3811

Query: 520  DPNLIPSAPSKPEVTDVSRNTVTLSWQPN---LNSGATPTSY 558
            +  +I +  +            +++W+ N   LN      SY
Sbjct: 3812 NMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSY 3853



 Score =  201 bits (511), Expect = 5e-51
 Identities = 145/485 (29%), Positives = 212/485 (43%), Gaps = 34/485 (7%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I  H  + +++  +P TL+C+A+G P P I W+K G  +          + +L SGS
Sbjct: 4078 PPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES-----IRQRVLSSGS 4132

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
            L    +  G     D G Y C+A N  G + S +  L V +     R       V     
Sbjct: 4133 LQIAFVQPG-----DAGHYTCMAANVAGSS-STSTKLTVHV-PPRIRSTEGHYTVNENSQ 4185

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNM 206
            A++ C    G P P I+WKKD   L +   + T    G+L++      D+G Y CV  N 
Sbjct: 4186 AILPCVAD-GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNA 4244

Query: 207  VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
             GE ++    LTV   P+F + P ++++   +     C+A G P+P + W  ++  +P  
Sbjct: 4245 AGE-DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH 4303

Query: 267  RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK-PRDQV 325
               +     L I +V+  D G+Y C AEN VG  +A   + V+   EPP F    P + +
Sbjct: 4304 FDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVK---EPPVFKGDYPSNWI 4360

Query: 326  VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385
              LG      CE  G+P P I W R+G           + S R      G L I      
Sbjct: 4361 EPLGGNAILNCEVKGDPTPTIQWNRKGVD--------IEISHRIRQLGNGSLAIYGTVNE 4412

Query: 386  DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445
            D G Y C   N AG +     L +      + PP+I   PV   +   G  +L+C ATG 
Sbjct: 4413 DAGDYTCVATNEAGVVERSMSLTL------QSPPIITLEPVETVINAGGKIILNCQATGE 4466

Query: 446  PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 505
            P PTI W + G  +S  D R+  L N  L I  A+  DT  + C+A    G       + 
Sbjct: 4467 PQPTITWSRQGHSIS-WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVI 4525

Query: 506  VQEFG 510
            VQ  G
Sbjct: 4526 VQVHG 4530



 Score =  193 bits (490), Expect = 1e-48
 Identities = 152/488 (31%), Positives = 231/488 (47%), Gaps = 50/488 (10%)

Query: 37   DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHG 96
            D+I++   P +L C+    P PT+ WYK G  + T  D      ++LP G +  +     
Sbjct: 2788 DVIINN--PISLYCETNAAPPPTLTWYKDGHPL-TSSDKV----LILPGGRVLQIP---- 2836

Query: 97   RKSRPDEGVYVCVARNYLGE-AVSHNASLEVA-ILRDDFRQNPSDVMVAVGEPAVMECQP 154
            R    D G Y CVA N  GE ++ ++  + V  I++      P +V V V + A++EC  
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLS 2896

Query: 155  PRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERESE 213
              G P P  SW+KDG PL + D    +  G+++ I  T+ +D G+YVCV  N  G  + +
Sbjct: 2897 S-GSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAK-K 2954

Query: 214  VAELTVLERPSFV-KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG--ELPKSRYEI 270
               L V   PS +  +  NL V V++     CE  G P P + W K++   +L  +   +
Sbjct: 2955 YFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIV 3014

Query: 271  RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV----- 325
                TL+I +    D G YTC+A N  G+++   +LTV V   PP   +K  D       
Sbjct: 3015 PGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYV---PPS--IKDHDSESLSVV 3069

Query: 326  -VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQ 383
             V  G +V+ +CE+   P P I W + G             S+   +   G  L I   +
Sbjct: 3070 NVREGTSVSLECESNAVPPPVITWYKNGRMIT--------ESTHVEILADGQMLHIKKAE 3121

Query: 384  RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCV 441
             SD G Y+C+ +NVAG      +L V        PP I +GP  + +   +     L+C 
Sbjct: 3122 VSDTGQYVCRAINVAGRDDKNFHLNVY------VPPSI-EGPEREVIVETISNPVTLTCD 3174

Query: 442  ATGSPVPTILWRKDGVLVSTQDS-RIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGEAT 499
            ATG P PTI W K+   +   DS  ++ L  G  LQI  ++  D+G YTCIAS   G+A 
Sbjct: 3175 ATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQ 3234

Query: 500  WSAYIEVQ 507
               ++ +Q
Sbjct: 3235 KYYFLSIQ 3242



 Score =  190 bits (482), Expect = 1e-47
 Identities = 150/505 (29%), Positives = 226/505 (44%), Gaps = 59/505 (11%)

Query: 34   HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
            HP+++IV++G+  +L C+ +G P PT+ W K G  +   K        +L  G +  L+ 
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE-----ILDEGHILQLKN 2352

Query: 94   VHGRKSRPDEGVYVCVARNYLGEA-VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
            +H      D G YVCVA N  G     ++ S+          ++P ++ V       + C
Sbjct: 2353 IHVS----DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTC 2408

Query: 153  QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERE 211
            +   G P P+I+W KDG P+   +    + GG+++ +  T   DAG+Y CV  N  GE E
Sbjct: 2409 EAS-GIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE-E 2466

Query: 212  SEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK--SR 267
             ++  L+VL  P  V   +  ++ V    S    CE  G+PVP + W KD   L +  + 
Sbjct: 2467 RKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAH 2526

Query: 268  YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-------QVGSEPPHFVVK 320
            + I     L+I  V     G YTC+A +  G    S +L V        VGS+       
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDG-----N 2581

Query: 321  PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTI 379
            P D  V L    +  CEA   P   I W ++G+        P +S+    +   G  L I
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFKDGT--------PLESNRNIRILPGGRTLQI 2633

Query: 380  TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--------PVNQTVA 431
             N Q  + G Y C   N AG +I   + EV   I    PP+I +G        P    + 
Sbjct: 2634 LNAQEDNAGRYSCVATNEAGEMIK--HYEVKVYI----PPIINKGDLWGPGLSPKEVKIK 2687

Query: 432  VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 491
            V+ T  L C A   P  ++ W KDG  + + D          LQI+ A++ DTGRYTC+A
Sbjct: 2688 VNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVA 2747

Query: 492  STPSGEATWSAYIEVQEFGVPVQPP 516
            S  +GE       +  +F V +Q P
Sbjct: 2748 SNIAGE-------DELDFDVNIQVP 2765



 Score =  189 bits (479), Expect = 2e-47
 Identities = 144/494 (29%), Positives = 226/494 (45%), Gaps = 43/494 (8%)

Query: 33   EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLR 92
            E  +++ V   +   L C+ EG P+P I WYK   +V        S    + +G +  L 
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES-----STIQTVNNGKILKLF 1419

Query: 93   IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN-PSDVMVAVGEPAVME 151
                R +  D G Y C A N  G +  +  +++V +       N P++V V +     +E
Sbjct: 1420 ----RATPEDAGRYSCKAINIAGTSQKY-FNIDVLVPPTIIGTNFPNEVSVVLNRDVALE 1474

Query: 152  CQPPRGHPEPTISWKKDGSPL--DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGE 209
            CQ  +G P P I W KDG PL   D +  +  RG  L +   R++D G+Y C  +N  G+
Sbjct: 1475 CQV-KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK 1533

Query: 210  RESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
            +  ++ +LT+   PS       ++++V ++   + +CE RG P+P + W KD   +  S 
Sbjct: 1534 QAKDI-KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS 1592

Query: 268  YEIRDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325
              +  D    L I +    D  +YTC   N+ G AE S  + V V       +  P ++ 
Sbjct: 1593 QALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQ 1652

Query: 326  VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQR 384
            V +  ++T +C+A GNP P + W ++G         P +++    +   G  L I + Q 
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGV--------PVKANDNIRIEAGGKKLEIMSAQE 1704

Query: 385  SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ--TVAVDGTFVLSCVA 442
             D G YIC   +VAG    K  ++V        PP I  G       V V+    L C  
Sbjct: 1705 IDRGQYICVATSVAGEKEIKYEVDVL------VPPAIEGGDETSYFIVMVNNLLELDCHV 1758

Query: 443  TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 502
            TGSP PTI+W KDG L+  +D     L    L I  A++ +TG Y C+A+  +G+     
Sbjct: 1759 TGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD----- 1813

Query: 503  YIEVQEFGVPVQPP 516
                +EF V V  P
Sbjct: 1814 --HKKEFEVTVHVP 1825



 Score =  187 bits (475), Expect = 7e-47
 Identities = 145/491 (29%), Positives = 223/491 (45%), Gaps = 38/491 (7%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
            P+++   S+L+V+ G+   + CK  G P P ++W+KG   +       R    L+    L
Sbjct: 702  PKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLEL-------RPSTFLIIDPLL 754

Query: 89   FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
              L+I   +    D G Y CVA N  G A     +L+V      F Q P+DV + +G   
Sbjct: 755  GLLKIQETQDL--DAGDYTCVAINEAGRATG-KITLDVG-SPPVFIQEPADVSMEIGSNV 810

Query: 149  VMECQPPRGHPEPTISWKK-DGSPLDDKDERIT----IRGGKLMITYTRKSDAGKYVCVG 203
             + C   +G+PEPTI W++ D  P+  +   ++    +R G L I     SD G Y+C  
Sbjct: 811  TLPCY-VQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA 869

Query: 204  TNMVGERESE-VAELTVLERPSFVKRPSNLAVTVDDSAEFKCE-ARGDPVPTVRWRKDDG 261
             N  G+ +SE    +T L  P     PS   V         C    G+P+P  RW K+  
Sbjct: 870  ENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSA 929

Query: 262  ELPKSRY-EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK 320
             L ++ Y  +R D +L I +V   D G YTCVA N+ G    + ++ V V     H    
Sbjct: 930  MLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQH---- 985

Query: 321  PRDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
               Q+++   G  VT  C+A+GNP+P++ W ++G    L S     SS++FS    G L 
Sbjct: 986  -GQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGE---LIS----TSSAKFSAGADGSLY 1037

Query: 379  ITNVQRSDVGYYICQTLNVAGSIITKAYLEV---TDVIADRPPPVIRQGPVNQTVAVDGT 435
            + +    + G Y+C   N AG    K  L V     V  D+   + +  PV  +V     
Sbjct: 1038 VVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQ-RGLSQDKPVEISVLAGEE 1096

Query: 436  FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
              L C     P P I W K+  L+S    R   L +G ++I   +  D+G Y C+A+  +
Sbjct: 1097 VTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIA 1156

Query: 496  GEATWSAYIEV 506
            G  T +  + V
Sbjct: 1157 GNVTQAVKLNV 1167



 Score =  187 bits (474), Expect = 9e-47
 Identities = 147/524 (28%), Positives = 224/524 (42%), Gaps = 32/524 (6%)

Query: 28   PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I   E   ++ V    P  L C A G P P + W K G  +      P++ ++    
Sbjct: 3526 PPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPL------PQTDQVQTLG 3579

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
            G    LRI   +    D G Y C+A +  G+                    P D+ V   
Sbjct: 3580 GGEV-LRISTAQVE--DTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRN 3636

Query: 146  EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGT 204
                +EC+     P P I+W ++G  L        + GG+ L I      D   Y CV +
Sbjct: 3637 RQVTLECKSD-AVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVAS 3695

Query: 205  NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
            N+ G+   E   LTV   P+    P +L + ++ S   +C A G P P + WRKD   L 
Sbjct: 3696 NIAGKTTREFI-LTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA 3754

Query: 265  --KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPR 322
               +RY I ++  L I+     D G Y C+A N  G       L V V   PP     P 
Sbjct: 3755 GNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHV---PPSIAPGPT 3811

Query: 323  DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 382
            +  V +    T  CEATG P+P+I WR+ G  +LL      Q+ + + +  +G L I + 
Sbjct: 3812 NMTVIVNVQTTLACEATGIPKPSINWRKNG--HLL---NVDQNQNSYRLLSSGSLVIISP 3866

Query: 383  QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 442
               D   Y C   N AG    K  +++T  +    PP I   P +  V      V++C A
Sbjct: 3867 SVDDTATYECTVTNGAGD--DKRTVDLTVQV----PPSIADEPTDFLVTKHAPAVITCTA 3920

Query: 443  TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 502
            +G P P+I W K+G+ +  +    + L +G ++I   +L   GRYTC+A   +G A    
Sbjct: 3921 SGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHV 3980

Query: 503  YIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 546
             + V E   PV  P+P++ ++I + P           +  ++WQ
Sbjct: 3981 TLHVHE--PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQ 4022



 Score =  186 bits (472), Expect = 2e-46
 Identities = 171/608 (28%), Positives = 270/608 (44%), Gaps = 94/608 (15%)

Query: 28   PPRIVEHPS--DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP IV   +  D+ V + +  TL C+  G P P I W+K G+ ++ D+    +H ++  S
Sbjct: 2477 PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE----AHHII--S 2530

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGE---AVSHNASLEVAILRDDFRQNPSDVMV 142
            G  F L+I + +   P  G Y C+A +  G    + S N  +   I       NP DV V
Sbjct: 2531 GGRF-LQITNVQV--PHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587

Query: 143  AVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVC 201
             +  P  + C+    +P  TI+W KDG+PL+ +++ RI   G  L I   ++ +AG+Y C
Sbjct: 2588 ILNSPTSLVCEA-YSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646

Query: 202  VGTNMVGERESEVAELTVLERPSFVK--------RPSNLAVTVDDSAEFKCEARGDPVPT 253
            V TN  GE      E+ V   P   K         P  + + V+++   +CEA   P  +
Sbjct: 2647 VATNEAGEMIKHY-EVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSAS 2705

Query: 254  VRWRKDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
            + W KD G+  KS   +    + HTL+I++    D G YTCVA N+ G+ E    + +QV
Sbjct: 2706 LSWYKD-GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQV 2764

Query: 311  GSEPPHFVV------------KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLF 358
               PP F                  + V +   ++  CE    P P + W ++G      
Sbjct: 2765 ---PPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG------ 2815

Query: 359  SYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
               P  SS +  +   G  L I   +  D G Y C  +N AG    +  + V        
Sbjct: 2816 --HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL------V 2867

Query: 418  PPVIRQG----PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG- 472
            PP+I+      P   TV V+ + ++ C+++GSP P   W+KDG  +  +D   K L NG 
Sbjct: 2868 PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL-LEDDHHKFLSNGR 2926

Query: 473  VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPE 532
            +LQI   ++ D GRY C+A   +G A        + F + V  P    P++I   P    
Sbjct: 2927 ILQILNTQITDIGRYVCVAENTAGSAK-------KYFNLNVHVP----PSVI--GPKSEN 2973

Query: 533  VTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNA 592
            +T V  N ++L+ +    SG  P              SW    + +K  T+ +  + P  
Sbjct: 2974 LTVVVNNFISLTCEV---SGFPPPDL-----------SWLKNEQPIKLNTNTL--IVPGG 3017

Query: 593  IYLFLVRA 600
              L ++RA
Sbjct: 3018 RTLQIIRA 3025



 Score =  184 bits (468), Expect = 5e-46
 Identities = 139/490 (28%), Positives = 209/490 (42%), Gaps = 30/490 (6%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP  ++ P+D+ +  G   TL C  +G P PTI+W +        +    S    L +G+
Sbjct: 792  PPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGA 851

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
            LF L +        D+G Y+C A N  G+  S        ++      +PS   V  G+ 
Sbjct: 852  LFILNLWAS-----DKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQ 906

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNM 206
              + C    G+P P   W K+ + L  ++  IT+R  G L I   +  D G+Y CV +N+
Sbjct: 907  LTLPCTLLAGNPIPERRWIKNSAMLL-QNPYITVRSDGSLHIERVQLQDGGEYTCVASNV 965

Query: 207  VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL--- 263
             G   ++   + V   P+       L+          C+A G+P P+V W K  GEL   
Sbjct: 966  AGTN-NKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKK-GELIST 1023

Query: 264  PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----GSEPPHFV 318
              +++    D +L +      + G Y C A N  G A+    LTV V     G +     
Sbjct: 1024 SSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQ 1083

Query: 319  VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
             KP +  V  G  VT  CE    P P I W +E    L+  + P     R +   +G + 
Sbjct: 1084 DKPVEISVLAGEEVTLPCEVKSLPPPIITWAKE--TQLISPFSP-----RHTFLPSGSMK 1136

Query: 379  ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
            IT  + SD G Y+C   N+AG++     L V        PP I++GP +  V V     +
Sbjct: 1137 ITETRTSDSGMYLCVATNIAGNVTQAVKLNV------HVPPKIQRGPKHLKVQVGQRVDI 1190

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
             C A G+P+P I W K G  +           +G L I  A   D G YTC+A+  +G  
Sbjct: 1191 PCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTD 1250

Query: 499  TWSAYIEVQE 508
                 + VQE
Sbjct: 1251 ETEITLHVQE 1260



 Score =  177 bits (449), Expect = 7e-44
 Identities = 158/553 (28%), Positives = 235/553 (42%), Gaps = 54/553 (9%)

Query: 28   PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I+    P+++ V       L C+ +G P P I W+K G+ +     DP     LL  
Sbjct: 1451 PPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG--DPNVE--LLDR 1506

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN-PSDVMVAV 144
            G +  L+       R D+G Y C   N  G+    +  L + I       N  +D+ V +
Sbjct: 1507 GQVLHLK----NARRNDKGRYQCTVSNAAGKQAK-DIKLTIYIPPSIKGGNVTTDISVLI 1561

Query: 145  GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 203
                 +EC+  RG P P I+W KDG P+    + + I +G  L I   + SD+  Y C  
Sbjct: 1562 NSLIKLECET-RGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHV 1620

Query: 204  TNMVGERESEVAELTVLERPSF---VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
             N+ G  E     + V   P     +  P N  V +  S   +C+A G+P P + W KD 
Sbjct: 1621 ANVAGTAEKSF-HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKD- 1678

Query: 261  GELPKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV------G 311
            G   K+   IR +     L+I      D G Y CVA ++ G+ E    + V V      G
Sbjct: 1679 GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGG 1738

Query: 312  SEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
             E  +F+V        +   +   C  TG+P P I W ++G        Q       F +
Sbjct: 1739 DETSYFIVM-------VNNLLELDCHVTGSPPPTIMWLKDG--------QLIDERDGFKI 1783

Query: 372  SQTG-DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
               G  L I   Q S+ G Y C   N AG    K   EVT  +    PP I+   +++ V
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGD--HKKEFEVTVHV----PPTIKSSGLSERV 1837

Query: 431  AVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYT 488
             V    V L C+A G P P+I W KD   V+T    +K   +G VLQI    L D GRYT
Sbjct: 1838 VVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYT 1897

Query: 489  CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
            C+A+  +GE      + V E        +  +  ++ S P + E          ++W  +
Sbjct: 1898 CVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKD 1957

Query: 549  --LNSGATPTSYI 559
              L SG+T  +++
Sbjct: 1958 NRLLSGSTSMTFL 1970



 Score =  176 bits (446), Expect = 2e-43
 Identities = 157/546 (28%), Positives = 235/546 (43%), Gaps = 67/546 (12%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I+    ++ V   +   L C+++  P PT+ W K G            H +L   G 
Sbjct: 2103 PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDG------------HPLLKKPG- 2149

Query: 88   LFFLRIVHGRK-------SRPDEGVYVCVARNYLGEA-VSHNASLEVAIL---RDDFRQN 136
               L I   R           D G Y C A N  G+   ++N ++ V       D+  Q 
Sbjct: 2150 ---LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ- 2205

Query: 137  PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--KLMITYTRK 193
               + V  G    + C+   G P P + WKK GSP L D   R+ I  G  +L I+   K
Sbjct: 2206 ---LTVIEGNLISLLCE-SSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEK 2261

Query: 194  SDAGKYVCVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDP 250
            SDA  Y CV +N+ G  + E   L V  RP+       P+ + VT   S   +CE +G P
Sbjct: 2262 SDAALYSCVASNVAGTAKKEY-NLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIP 2320

Query: 251  VPTVRWRKDDGELPKSR-YEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
             PTV W KD   L K++  EI D+ H L+++ +   D G Y CVA N+ G  +    L+V
Sbjct: 2321 PPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSV 2380

Query: 309  QVGSEPPHFV---VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 365
                 PP  +     P +  V    +V+  CEA+G P P+I W ++G       +    S
Sbjct: 2381 HA---PPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDG-------WPVSLS 2430

Query: 366  SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 425
            +S   +S    L +      D G Y C   N AG        ++  +    PP ++ +  
Sbjct: 2431 NSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE-----ERKIFGLSVLVPPHIVGENT 2485

Query: 426  VNQT-VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 484
            +    V    +  L+C  TG+PVP I W KDG  +   ++         LQI   ++  T
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHT 2545

Query: 485  GRYTCIASTPSGEATWSAYIEVQEFGVPV-----QPPRPTDPNLIPSAPSKPEVTDVSRN 539
            GRYTC+AS+P+G  + S  + V  F  P          P D  +I ++P+       S  
Sbjct: 2546 GRYTCLASSPAGHKSRSFSLNV--FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYP 2603

Query: 540  TVTLSW 545
              T++W
Sbjct: 2604 PATITW 2609



 Score =  174 bits (441), Expect = 6e-43
 Identities = 160/566 (28%), Positives = 240/566 (42%), Gaps = 62/566 (10%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP +++ P+++ V+ GE A L C         + W +          + R  R+  P+  
Sbjct: 519  PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQR----------NDRDVRLAEPARI 568

Query: 88   LFFLRIVHGRKSRP--DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-- 143
                 +    KS    D G Y C+  +   E  S  AS+ + +      Q P  V V   
Sbjct: 569  RTLANLSLELKSVKFNDAGEYHCMVSS---EGGSSAASVFLTV------QEPPKVTVMPK 619

Query: 144  ----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKY 199
                 G   V       G+P+P I+W  +   +           G L I      DAG Y
Sbjct: 620  NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIY 679

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
             C+ +N  G  + + + L  +E P  +   S L V + D    +C+  G P P V+W K 
Sbjct: 680  GCLASNSAG-TDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKG 738

Query: 260  DGELPKSRYEIRDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
            D EL  S + I D     LKI++    D G YTCVA N  G+  A+  +T+ VGS PP F
Sbjct: 739  DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGR--ATGKITLDVGS-PPVF 795

Query: 318  VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
            + +P D  + +G  VT  C   G P+P I WRR  +  +   +  P S S  S  +TG L
Sbjct: 796  IQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI---FSRPFSVSSISQLRTGAL 852

Query: 378  TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
             I N+  SD G YIC+  N  G I ++  + VT ++A    P+I   P    V       
Sbjct: 853  FILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVA----PLIGISPSVANVIEGQQLT 908

Query: 438  LSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 496
            L C +  G+P+P   W K+  ++  Q+  I    +G L I   +L D G YTC+AS  +G
Sbjct: 909  LPCTLLAGNPIPERRWIKNSAML-LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAG 967

Query: 497  --EATWSAYIEV-------QEF-----GVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVT 542
                T S  + V       Q+      G+PV  P     N       KP V    +  + 
Sbjct: 968  TNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGN------PKPSVIWSKKGELI 1021

Query: 543  LSWQPNLNSGATPTSYIIEAFSHASG 568
             +     ++GA  + Y++      SG
Sbjct: 1022 STSSAKFSAGADGSLYVVSPGGEESG 1047



 Score =  174 bits (441), Expect = 6e-43
 Identities = 141/471 (29%), Positives = 202/471 (42%), Gaps = 37/471 (7%)

Query: 36   SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
            +D+ V       L C+  G P P I WYK G+ + +      S  + +  G   +L I  
Sbjct: 1555 TDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS-----SQALYIDKGQ--YLHIPR 1607

Query: 96   GRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQP 154
             + S  D   Y C   N  G A  S +  + V  + +     P +  V +     +EC+ 
Sbjct: 1608 AQVS--DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKA 1665

Query: 155  PRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213
              G+P P ++W KDG P+   D  RI   G KL I   ++ D G+Y+CV T++ GE+E +
Sbjct: 1666 A-GNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK 1724

Query: 214  VAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271
              E+ VL  P+       S   V V++  E  C   G P PT+ W KD G+L   R   +
Sbjct: 1725 Y-EVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD-GQLIDERDGFK 1782

Query: 272  ---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP-RDQVVA 327
               +   L I +    + G Y C+A N  G  +    +TV V   PP        ++VV 
Sbjct: 1783 ILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHV---PPTIKSSGLSERVVV 1839

Query: 328  LGRTVTFQCEATGNPQPAIFWRREGSQ-NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 386
              + V  QC A G P P+I W ++    N        QSS R        L I      D
Sbjct: 1840 KYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV-------LQIAKTLLED 1892

Query: 387  VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGS 445
             G Y C   N AG       L V +     PP +   G + N+TV V     L C A G+
Sbjct: 1893 AGRYTCVATNAAGETQQHIQLHVHE-----PPSLEDAGKMLNETVLVSNPVQLECKAAGN 1947

Query: 446  PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 496
            PVP I W KD  L+S   S        ++ I  A++ D G Y C+A   +G
Sbjct: 1948 PVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG 1998



 Score =  174 bits (440), Expect = 8e-43
 Identities = 137/476 (28%), Positives = 213/476 (44%), Gaps = 44/476 (9%)

Query: 36   SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
            S+ +V K +P  L C A G P P+I W K  + V T + + +    +  SG +  +    
Sbjct: 1834 SERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK----IQSSGRVLQI---- 1885

Query: 96   GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM---VAVGEPAVMEC 152
             +    D G Y CVA N  GE   H   +++ +      ++   ++   V V  P  +EC
Sbjct: 1886 AKTLLEDAGRYTCVATNAAGETQQH---IQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC 1942

Query: 153  QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERE 211
            +   G+P P I+W KD   L        +  G+++ I   + SDAG Y CV  N  G  E
Sbjct: 1943 KAA-GNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATE 2001

Query: 212  SEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-- 269
               + L V   PS     + +AV V++    +CEARG P P++ W KD    P S +   
Sbjct: 2002 LFYS-LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGS--PVSSFSNG 2058

Query: 270  ---IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVV 326
               +     L +      D G YTCVA N  G+ +    L V V   PP+ + + ++  V
Sbjct: 2059 LQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV---PPNIMGEEQNVSV 2115

Query: 327  ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRS 385
             + + V   C++   P P + W ++G         P       S+S+    L I + Q  
Sbjct: 2116 LISQAVELLCQSDAIPPPTLTWLKDG--------HPLLKKPGLSISENRSVLKIEDAQVQ 2167

Query: 386  DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSCVATG 444
            D G Y C+  NVAG   T+    V   +   PP +     + Q   ++G  + L C ++G
Sbjct: 2168 DTGRYTCEATNVAGK--TEKNYNVNIWV---PPNIGGSDELTQLTVIEGNLISLLCESSG 2222

Query: 445  SPVPTILWRKDGVLVSTQD-SRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 498
             P P ++W+K G  V T    R++ L  G  LQI  A+  D   Y+C+AS  +G A
Sbjct: 2223 IPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278



 Score =  170 bits (431), Expect = 9e-42
 Identities = 143/497 (28%), Positives = 214/497 (43%), Gaps = 45/497 (9%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP++   P +   + G   ++ C A G P P I W         D     SHR  + S  
Sbjct: 611  PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAW------TVNDMFIVGSHRYRMTSDG 664

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
              F++      +  D G+Y C+A N  G     N++L   I         S+++VA+G+ 
Sbjct: 665  TLFIK----NAAPKDAGIYGCLASNSAG-TDKQNSTLRY-IEAPKLMVVQSELLVALGDI 718

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCVGT 204
             VMEC+   G P P + W K    L+ +     I     G L I  T+  DAG Y CV  
Sbjct: 719  TVMECK-TSGIPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAI 775

Query: 205  NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG--- 261
            N  G    ++  L V   P F++ P+++++ +  +    C  +G P PT++WR+ D    
Sbjct: 776  NEAGRATGKIT-LDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 834

Query: 262  -ELPKSRYEIRDDHT--LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
               P S   I    T  L I  + A D G+Y C AEN  GK ++  T+TV  G   P   
Sbjct: 835  FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTV-TGLVAPLIG 893

Query: 319  VKPRDQVVALGRTVTFQCE-ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
            + P    V  G+ +T  C    GNP P   W +  +  L   Y         +V   G L
Sbjct: 894  ISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPY--------ITVRSDGSL 945

Query: 378  TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
             I  VQ  D G Y C   NVAG+   K    V  V+     P I+ G    +        
Sbjct: 946  HIERVQLQDGGEYTCVASNVAGT-NNKTTSVVVHVL-----PTIQHGQQILSTIEGIPVT 999

Query: 438  LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
            L C A+G+P P+++W K G L+ST  ++     +G L +      ++G Y C A+  +G 
Sbjct: 1000 LPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGY 1059

Query: 498  A----TWSAYIEVQEFG 510
            A      + Y+  + FG
Sbjct: 1060 AKRKVQLTVYVRPRVFG 1076



 Score =  168 bits (425), Expect = 4e-41
 Identities = 151/537 (28%), Positives = 239/537 (44%), Gaps = 72/537 (13%)

Query: 35   PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
            P ++ +      TL C+A   P+ ++ WYK G+ +++D      H  +  +G    L+I 
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSD-----DHVNIAANGHT--LQIK 2733

Query: 95   HGRKSRPDEGVYVCVARNYLGE-----------AVSHNASLEVAILRDDFRQNPSDVMVA 143
              + S  D G Y CVA N  GE             S     E+  + D  R   +  ++ 
Sbjct: 2734 EAQIS--DTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVI- 2790

Query: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCV 202
            +  P  + C+     P PT++W KDG PL   D+ + + GG+ L I   +  DAG+Y CV
Sbjct: 2791 INNPISLYCET-NAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCV 2849

Query: 203  GTNMVGERESEVAELTVLERPSFVKR-----PSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
              N  GE +S   ++ VL  P  +K      P  + V V+ SA  +C + G P P   W+
Sbjct: 2850 AVNEAGE-DSLQYDVRVLV-PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQ 2907

Query: 258  KDDGELPKSRYE--IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
            KD   L +  +   + +   L+I      D+G Y CVAEN  G A+    L V V    P
Sbjct: 2908 KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV----P 2963

Query: 316  HFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
              V+ P+ +   V +   ++  CE +G P P + W        L + QP + ++   +  
Sbjct: 2964 PSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSW--------LKNEQPIKLNTNTLIVP 3015

Query: 374  TG-DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
             G  L I   + SD G Y C  +N AG    K  L V        PP I+         V
Sbjct: 3016 GGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY------VPPSIKDHDSESLSVV 3069

Query: 433  ---DGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRY 487
               +GT V L C +   P P I W K+G ++ T+ + ++ L +G +L I+ A++ DTG+Y
Sbjct: 3070 NVREGTSVSLECESNAVPPPVITWYKNGRMI-TESTHVEILADGQMLHIKKAEVSDTGQY 3128

Query: 488  TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
             C A   +G    + ++ V    VP        P++    P +  + +   N VTL+
Sbjct: 3129 VCRAINVAGRDDKNFHLNVY---VP--------PSI--EGPEREVIVETISNPVTLT 3172



 Score =  167 bits (423), Expect = 8e-41
 Identities = 143/503 (28%), Positives = 220/503 (43%), Gaps = 62/503 (12%)

Query: 28   PPRIVEH---PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            PP I+ +   P ++ V +    +L C+A G P P+I W+K G  V        S+ + + 
Sbjct: 2383 PPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSL------SNSVRIL 2436

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVA 143
            SG    LR++  + +  D G Y CV RN  GE       L V +      +N   DV V 
Sbjct: 2437 SGGRM-LRLM--QTTMEDAGQYTCVVRNAAGEE-RKIFGLSVLVPPHIVGENTLEDVKVK 2492

Query: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCV 202
              +   + C+   G+P P I+W KDG PL + +    I GG+ L IT  +    G+Y C+
Sbjct: 2493 EKQSVTLTCEVT-GNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCL 2551

Query: 203  GTNMVGERESEVAELTVLERPSFVK-----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
             ++  G + S    L V   P+         P ++ V ++      CEA   P  T+ W 
Sbjct: 2552 ASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWF 2610

Query: 258  KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
            KD   L  +R  IR      TL+I      + G Y+CVA N  G+      + V +   P
Sbjct: 2611 KDGTPLESNR-NIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYI---P 2666

Query: 315  PHFV--------VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 366
            P           + P++  + +  T+T +CEA   P  ++ W ++G        QP +S 
Sbjct: 2667 PIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDG--------QPLKSD 2718

Query: 367  SRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 425
               +++  G  L I   Q SD G Y C   N+AG    +  L+  DV    PP   +   
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG----EDELDF-DVNIQVPPSFQKLWE 2773

Query: 426  VN-----------QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 474
            +            + V ++    L C    +P PT+ W KDG  +++ D  +      VL
Sbjct: 2774 IGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVL 2833

Query: 475  QIRYAKLGDTGRYTCIASTPSGE 497
            QI  AK+ D GRYTC+A   +GE
Sbjct: 2834 QIPRAKVEDAGRYTCVAVNEAGE 2856



 Score =  166 bits (420), Expect = 2e-40
 Identities = 150/487 (30%), Positives = 217/487 (44%), Gaps = 47/487 (9%)

Query: 28   PPRIVEHPSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
            PP ++   S+ L V      +L C+  G P P + W K  + ++ +     ++ +++P G
Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLN-----TNTLIVPGG 3017

Query: 87   SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVA 143
                L+I+  + S  D G Y C+A N  GE+     SL V +   ++D   ++ S V V 
Sbjct: 3018 RT--LQIIRAKVS--DGGEYTCIAINQAGES-KKKFSLTVYVPPSIKDHDSESLSVVNVR 3072

Query: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCV 202
             G    +EC+     P P I+W K+G  + +     I   G  L I     SD G+YVC 
Sbjct: 3073 EGTSVSLECES-NAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCR 3131

Query: 203  GTNMVGERESEVAELTVLERPSFVKRPSNLAV-TVDDSAEFKCEARGDPVPTVRWRKDDG 261
              N+ G R+ +   L V   PS       + V T+ +     C+A G P PT+ W K+  
Sbjct: 3132 AINVAG-RDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK 3190

Query: 262  ELPKS-RYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
             +  S   E+R       L+I +    D G+YTC+A NM GKA+    L++QV   PP  
Sbjct: 3191 RIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQV---PPSV 3247

Query: 318  VVK--PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS--SSRFSVSQ 373
                 P D  V LG  V   C A G P P I W ++G        +P  S  + R  VS 
Sbjct: 3248 AGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDG--------KPIASGETERIRVSA 3299

Query: 374  TGD-LTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
             G  L I     SD G Y C   N AG    I    + VT  I        +        
Sbjct: 3300 NGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGN-----KDEAEKLMT 3354

Query: 431  AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTC 489
             VD +  + C ATG+P P I W K+G L     S I+ L  G V++I  A++ D   YTC
Sbjct: 3355 LVDTSINIECRATGTPPPQINWLKNG-LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTC 3413

Query: 490  IASTPSG 496
            +AS  +G
Sbjct: 3414 VASNRAG 3420



 Score =  165 bits (418), Expect = 3e-40
 Identities = 139/498 (27%), Positives = 214/498 (42%), Gaps = 42/498 (8%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
            P I    + + V    P  L C+A G P P++ W K G  V +  +  +    +L  G +
Sbjct: 2012 PSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQ----VLSGGRI 2067

Query: 89   FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
              L          D G Y CVA N  GE    +  L V +   +      +V V + +  
Sbjct: 2068 LALTSAQ----ISDTGRYTCVAVNAAGEK-QRDIDLRVYV-PPNIMGEEQNVSVLISQAV 2121

Query: 149  VMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
             + CQ     P PT++W KDG PL  K    I+     L I   +  D G+Y C  TN+ 
Sbjct: 2122 ELLCQSD-AIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180

Query: 208  GERESEV-AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-LPK 265
            G+ E      + V          + L V   +     CE+ G P P + W+K     L  
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTD 2240

Query: 266  SRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPR 322
            S   +R       L+I      D   Y+CVA N+ G A+    L V +     +    P 
Sbjct: 2241 SMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPT 2300

Query: 323  DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITN 381
            + +V  G++++ +CE  G P P + W ++G         P   +    +   G  L + N
Sbjct: 2301 EIIVTRGKSISLECEVQGIPPPTVTWMKDG--------HPLIKAKGVEILDEGHILQLKN 2352

Query: 382  VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI--RQGPVNQTVAVDGTFVLS 439
            +  SD G Y+C  +NVAG +  K Y    D+    PP +I   + P N +V    +  L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAG-MTDKKY----DLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407

Query: 440  CVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 498
            C A+G P+P+I W KDG  VS  +S ++ L  G +L++    + D G+YTC+    +GE 
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNS-VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE- 2465

Query: 499  TWSAYIEVQEFGVPVQPP 516
                  E + FG+ V  P
Sbjct: 2466 ------ERKIFGLSVLVP 2477



 Score =  157 bits (397), Expect = 8e-38
 Identities = 139/528 (26%), Positives = 215/528 (40%), Gaps = 65/528 (12%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            P I   PS   V +G+  TL C    G P P   W K    +  +      +  +   GS
Sbjct: 890  PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNP-----YITVRSDGS 944

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV-GE 146
            L   R+        D G Y CVA N  G   ++N +  V +      Q+   ++  + G 
Sbjct: 945  LHIERV-----QLQDGGEYTCVASNVAG---TNNKTTSVVVHVLPTIQHGQQILSTIEGI 996

Query: 147  PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 205
            P  + C+   G+P+P++ W K G  +     + +    G L +      ++G+YVC  TN
Sbjct: 997  PVTLPCKAS-GNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN 1055

Query: 206  MVGERESEVAELTVLERPSFV--------KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
              G  + +V +LTV  RP            +P  ++V   +     CE +  P P + W 
Sbjct: 1056 TAGYAKRKV-QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWA 1114

Query: 258  KDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
            K+   +     R+      ++KI +    D G Y CVA N+ G    +  L V V   PP
Sbjct: 1115 KETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHV---PP 1171

Query: 316  HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
                 P+   V +G+ V   C A G P P I W + GS  L+              +  G
Sbjct: 1172 KIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV-------DGEHHVSNPDG 1224

Query: 376  DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD--VIADRPPP---VIRQGPVNQTV 430
             L+I     SD G Y C   N+AG+  T+  L V +   + D  PP     ++   NQ +
Sbjct: 1225 TLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRI 1284

Query: 431  AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTC 489
                     C A G+P PTI W  +G  ++ ++  I  LE+G +L I      D G Y C
Sbjct: 1285 E------FPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYIC 1338

Query: 490  IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS 537
            +A   +G          +++ + V  P        P    K +VT+VS
Sbjct: 1339 VAVNEAGTTE-------RKYNLKVHVP--------PVIKDKEQVTNVS 1371



 Score =  155 bits (391), Expect = 4e-37
 Identities = 140/484 (28%), Positives = 201/484 (41%), Gaps = 37/484 (7%)

Query: 28   PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP +   E PSD+ V  GE   L C A G PTP I+W K G+ + + + +      +  S
Sbjct: 3244 PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETE-----RIRVS 3298

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVS-HNASLEVAILRDDFRQNPSDVMVAV 144
             +   L I     S  D G Y CVA N  GE     N ++ V       +     +M  V
Sbjct: 3299 ANGSTLNIYGALTS--DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLV 3356

Query: 145  GEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVCVG 203
                 +EC+   G P P I+W K+G PL      R+   G  + I   + SD   Y CV 
Sbjct: 3357 DTSINIECR-ATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVA 3415

Query: 204  TNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWRKDDG 261
            +N  G  +++   L V   P+         +TV    S    C   G P P++ W +D  
Sbjct: 3416 SNRAGV-DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474

Query: 262  ELPKSRYEIRDDH--TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
             L    +     H   L++ K    D G YTC+A N  G+      L V    EPPH   
Sbjct: 3475 PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV---LEPPHING 3531

Query: 320  KPRDQVVA--LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
                + ++  +   +   C A+G P P + W ++G          PQ+    ++     L
Sbjct: 3532 SEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGR-------PLPQTDQVQTLGGGEVL 3584

Query: 378  TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI-RQGPVNQTVAVDGTF 436
             I+  Q  D G Y C   + AG    K YL    V    PP +     P + TV  +   
Sbjct: 3585 RISTAQVEDTGRYTCLASSPAGD-DDKEYLVRVHV----PPNIAGTDEPRDITVLRNRQV 3639

Query: 437  VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPS 495
             L C +   P P I W ++G  +     R++ L  G  LQI  A LGDT  YTC+AS  +
Sbjct: 3640 TLECKSDAVPPPVITWLRNGERLQA-TPRVRILSGGRYLQINNADLGDTANYTCVASNIA 3698

Query: 496  GEAT 499
            G+ T
Sbjct: 3699 GKTT 3702



 Score =  117 bits (293), Expect = 9e-26
 Identities = 97/358 (27%), Positives = 155/358 (43%), Gaps = 21/358 (5%)

Query: 162 TISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE 221
           T+S+ ++G  L             L I     SD G Y C+  +  G   ++     V E
Sbjct: 460 TLSFVRNGVTLGVDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTF-FDVSE 518

Query: 222 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKI 278
            P  ++ P+N+ VT  + A   C         + W+++D ++     +R     + +L++
Sbjct: 519 PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLEL 578

Query: 279 RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEA 338
           + V   D G Y C+  +  G + AS  LTVQ   EPP   V P++Q    G  V+  C A
Sbjct: 579 KSVKFNDAGEYHCMVSSEGGSSAASVFLTVQ---EPPKVTVMPKNQSFTGGSEVSIMCSA 635

Query: 339 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 398
           TG P+P I W    + N +F       S R+ ++  G L I N    D G Y C   N A
Sbjct: 636 TGYPKPKIAW----TVNDMFIV----GSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSA 687

Query: 399 GSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVL 458
           G+    + L   +     P  ++ Q  +   VA+    V+ C  +G P P + W K  + 
Sbjct: 688 GTDKQNSTLRYIEA----PKLMVVQSEL--LVALGDITVMECKTSGIPPPQVKWFKGDLE 741

Query: 459 VSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 516
           +      I     G+L+I+  +  D G YTC+A   +G AT    ++V    V +Q P
Sbjct: 742 LRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEP 799



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 47/149 (31%), Positives = 75/149 (50%), Gaps = 13/149 (8%)

Query: 372 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 431
           S + +L I  V  SD G+Y C  ++ AG+   + + +V++     PPPVI Q P N TV 
Sbjct: 479 SASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE-----PPPVI-QVPNNVTVT 532

Query: 432 VDGTFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490
                VL+C+   +    + W R D  +   + +RI+ L N  L+++  K  D G Y C+
Sbjct: 533 PGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCM 592

Query: 491 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 519
            S+  G +  S ++ VQE      PP+ T
Sbjct: 593 VSSEGGSSAASVFLTVQE------PPKVT 615


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  218 bits (555), Expect = 4e-56
 Identities = 224/828 (27%), Positives = 342/828 (41%), Gaps = 103/828 (12%)

Query: 35  PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
           P D +  +G    LNC A   P+P IEW K G  +    DD    R LLP GSLF   +V
Sbjct: 59  PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115

Query: 95  HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
           H + ++PDEG Y CVA    LG  +S  A L VA L   F   P    V  G  A++ C+
Sbjct: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174

Query: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213
                  P + W+++  PL   D  I +  G L+I+   + D G Y CV  +    + S+
Sbjct: 175 -VNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233

Query: 214 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---P 264
             EL VL  P       F+K+PS L   +       C A G P PT++W K++  L    
Sbjct: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293

Query: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ 324
             R  +    +L+I  VT  D G+Y C+A+N     EA A LTVQ     P F+ +P + 
Sbjct: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQA---QPEFLKQPTNI 350

Query: 325 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384
                  + F+CE TG P P + W + G   +   Y        F + +  +L +  + +
Sbjct: 351 YAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVK 402

Query: 385 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVAT 443
           SD G+Y C   N  G+    A L + +       P +   P +   ++  T F+     T
Sbjct: 403 SDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRT 461

Query: 444 GSPVP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIAST 493
            +  P       ++ + K+G+       R++   + G +Q+    L     Y    +A  
Sbjct: 462 PASDPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQN 517

Query: 494 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 553
             G    SA + V E    VQ P P  PNL   A         S  ++T++W+  ++   
Sbjct: 518 KHGSGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNG 567

Query: 554 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQ 611
              +Y +      +         +V + +  I GLK    Y F V A N +  G+S P  
Sbjct: 568 EIQNYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV 624

Query: 612 ISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYI 668
               V+T   +P++             N  L + N     S SI +HW       Q+  I
Sbjct: 625 ---AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQI 666

Query: 669 QGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE 728
            GYKI YR +      ++ LV    +  + S +I  L +G  Y  +         G  ++
Sbjct: 667 TGYKIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATD 722

Query: 729 IKFAKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
              A+T E         E PS+      V       T+I+VSW PP  + QN +V+ Y +
Sbjct: 723 WLSAETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAI 773

Query: 780 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
            + +G+     I   VD       I  L P   Y + + A    G G+
Sbjct: 774 GYGIGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819



 Score =  145 bits (367), Expect = 2e-34
 Identities = 219/889 (24%), Positives = 344/889 (38%), Gaps = 138/889 (15%)

Query: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
           PR    P    V  G  A LNC+      P + W +  + +  D        + LPSG L
Sbjct: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206

Query: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 141
                  G     D G+Y CV  +  G    ++  +E+ +L D        F + PS ++
Sbjct: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259

Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKSDAGKY 199
             +G+  V+ C    G P PTI W K+   LD +  ER+ +  GG L I+   + DAG Y
Sbjct: 260 RVIGQDVVLPCVAS-GLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318

Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
            C+  N     E++ AELTV  +P F+K+P+N+         F+CE  G P PTV+W K+
Sbjct: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377

Query: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QVGSEPPH 316
            D  +P   ++I  +H L++  +   D G Y C+AEN VG A+A A L +     +    
Sbjct: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437

Query: 317 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 371
               PRD V +L  T   +          + WR   S     NL +S +   +  +R  V
Sbjct: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487

Query: 372 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426
             T       +TI N+  + V  +     N  GS  + A L V     +  P V   GP 
Sbjct: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542

Query: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 485
                      L   A      T+ W        T  S   +++N   ++ Y + G D  
Sbjct: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584

Query: 486 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 535
           +   ++S   T +G   ++ Y    +   + G  V  P      L  +PS AP    +  
Sbjct: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644

Query: 536 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 590
            +  ++ + WQP          T Y I    +   S    V E + + T     I+GL  
Sbjct: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701

Query: 591 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 650
              Y F V A     I+     +D +  +        +D  +V     +  LH+  P V 
Sbjct: 702 GTEYNFRVAALT---INGTGPATDWLSAETF---ESDLDETRVPEVPSS--LHV-RPLV- 751

Query: 651 SSSSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 709
             +SI V WT  + Q+  ++GY I Y   G+ H ++  + ++ R        I +L    
Sbjct: 752 --TSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTIENLDPSS 803

Query: 710 NYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAPPQGVTVS 749
           +Y I  + F N  +G               SE+        +    +  P  PP GV  S
Sbjct: 804 HYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQAS 863

Query: 750 KNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPG 809
               +   I  +    P+  +    + Y V    N       K  + +T S ++  L P 
Sbjct: 864 ILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPN 923

Query: 810 IRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 853
             Y   V  + G  S   S      + AHG      P SP   V++  +
Sbjct: 924 TLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966



 Score =  120 bits (302), Expect = 8e-27
 Identities = 189/864 (21%), Positives = 328/864 (37%), Gaps = 95/864 (10%)

Query: 32   VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
            ++ PS L+   G+   L C A G PTPTI+W K  E ++T+  +     +LL  GSL   
Sbjct: 252  LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308

Query: 92   RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
             +     +  D G Y C+A N   E +   A L V   + +F + P+++        V E
Sbjct: 309  DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361

Query: 152  CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
            C+   G P PT+ W K+G  +   D    ++   L +    KSD G Y C+  N VG  +
Sbjct: 362  CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420

Query: 212  SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 259
            +  A+L +LE            P ++  ++  +   K   R       GD +    +   
Sbjct: 421  AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479

Query: 260  DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPH 316
            +G + + R E      +  + I+ +    +  +  +A+N  G  E+SA L V+   E   
Sbjct: 480  EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538

Query: 317  FVVKPRDQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                P  +  A   T   VT++   +GN +          QN    Y    +     V  
Sbjct: 539  PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589

Query: 374  TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 429
            +    TI  +++     +     N  G  ++    A   ++DV +  P  +  +   +++
Sbjct: 590  SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649

Query: 430  VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 483
            + +           G      I +RK     D        +++ QL  G+ +      G 
Sbjct: 650  IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703

Query: 484  TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
               +   A T +G    + ++  + F   +   R      +P  PS   V  +   ++ +
Sbjct: 704  EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756

Query: 544  SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 602
            SW P  N       Y   A  +  GS   QT+  + K     I+ L P++ Y+  ++A N
Sbjct: 757  SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813

Query: 603  AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 650
              G   P   S ++ P   T +V       P +   D   +   +G     L + T+   
Sbjct: 814  NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873

Query: 651  -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 709
             + +S+  H  +     Y   +K    P+   +  ++            S ++  L+   
Sbjct: 874  WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924

Query: 710  NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 769
             YE              S      T E  P++PP+ VTV   +G    I+V+WQPP E  
Sbjct: 925  LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982

Query: 770  QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
             NG +  Y ++    +  E    + + V G+  +  I  L     Y  ++ A    G G 
Sbjct: 983  ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042

Query: 827  KSEP-QFIQLDAHGNPVSPEDQVS 849
             SE  QF    A  +   P DQ S
Sbjct: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 147/633 (23%), Positives = 218/633 (34%), Gaps = 95/633 (15%)

Query: 225 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 281
           F+  P +       S    C A  +P P + W+KD   L      R ++  D +L I  V
Sbjct: 55  FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114

Query: 282 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
                   D G Y CVA  E++      +A L V   +  P F  +P    V  G     
Sbjct: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIV---AGLPRFTSQPEPSSVYAGNNAIL 171

Query: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 394
            CE   +  P + W +        + QP     R     +G L I+N    D G Y C  
Sbjct: 172 NCEVNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVV 223

Query: 395 LNVA----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445
            +         +    L   +VI+D     +P P++R         +    VL CVA+G 
Sbjct: 224 ESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGL 275

Query: 446 PVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYI 504
           P PTI W K+   + T+ S R+  L  G L+I      D G Y CIA   +G  T  A  
Sbjct: 276 PTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQA 333

Query: 505 EVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS 564
           E+     P    +PT+     S     E     + T T+ W  N      P+ Y      
Sbjct: 334 ELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKE 392

Query: 565 H---------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDP 615
           H         +    +Q +AEN      A          L ++  A A     PS   D 
Sbjct: 393 HNLQVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDV 445

Query: 616 VKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILY 675
           V                               +++S+  I++ W       +  G  + Y
Sbjct: 446 V------------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTY 473

Query: 676 RPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTL 735
                  G +   V     P +  V I +L     Y  +         G  S     +T 
Sbjct: 474 SVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQ 533

Query: 736 EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD 795
            E    P     +     + T+I V+W+ P   + NG +Q YK++ +   T     + VD
Sbjct: 534 PEV-QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVD 588

Query: 796 GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828
            S+ S  I  L     YS  V A    G GV +
Sbjct: 589 VSSHSYTINGLKKYTEYSFRVVAYNKHGPGVST 621


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score =  214 bits (546), Expect = 4e-55
 Identities = 228/874 (26%), Positives = 345/874 (39%), Gaps = 88/874 (10%)

Query: 10  LFGLICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGG 66
           LF  + +C    +   D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G
Sbjct: 9   LFLSVTMCLSESV---DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65

Query: 67  ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV 126
             ++ + D    +R  L  G+     I+       D G Y C+A N +G  +S  A+L+ 
Sbjct: 66  TEIDLESD----YRYSLIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 117

Query: 127 AILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRG 183
           A L +   +  S V V  G+  V+ C PP   PE   SW  +  P    +D    I+   
Sbjct: 118 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQET 177

Query: 184 GKLMITYTRKSDAGKYVCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLA 233
           G L I+  + SD G Y+C+  N V      S    LT+         E    V  P  + 
Sbjct: 178 GNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVT 237

Query: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 293
                + + +C A G+PVPT+ W K +G +P      +    L+I  V   D G Y C A
Sbjct: 238 AAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA 297

Query: 294 ENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353
           EN  GK      L V      PH+V K  D  +  G  + ++C+ATG P+P   W + G 
Sbjct: 298 ENSRGKNSFRGQLQVYT---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG- 353

Query: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413
                   P    SR  +   G L I NV +SD G Y C   N  G+I   A L+   ++
Sbjct: 354 -------VPLSPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---IL 402

Query: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473
           A  P   + Q      V  D   V+ C   GSP PTI W+K G     ++ RI  L +G 
Sbjct: 403 ASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGS 461

Query: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533
           L+I  A   D G+Y C      G A   A + V+E            P  I   P + E+
Sbjct: 462 LRILNASKSDEGKYVCRGENVFGSAEIIASLSVKE------------PTRIELTPKRTEL 509

Query: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAI 593
           T     ++ L+ +   ++    T Y                 E+++ + S+   +  N  
Sbjct: 510 T--VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN-- 565

Query: 594 YLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSS 653
              L+  A  YG           + Q    +        V+   G   + +      S++
Sbjct: 566 --ILLMHAGRYG----------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTA 613

Query: 654 SIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEI 713
           ++      D  S  I  Y +  R   +   ++   V E+ T    S +  DL   V YE 
Sbjct: 614 TLSWSPAADNHSP-ISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEF 672

Query: 714 KARPFFNEFQGAD--SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQN 771
           +     N     D  +  +  +T E  P   P    VS   G    ++++W+P  E+ QN
Sbjct: 673 RV-VATNPIGTGDPSTPSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQN 729

Query: 772 GMVQEYKVWCLGNETRYHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSG 825
           G    Y V    N TR    K V  S  S  I      P L P   + V+V      G G
Sbjct: 730 GEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDG 786

Query: 826 VKSEPQFIQLDAHGNP-VSPEDQVSLAQQISDVV 858
             S+   I   A G P  +P D  + +  +S+++
Sbjct: 787 PFSQIVVI-CSAEGEPSAAPTDVKATSVSVSEIL 819



 Score =  175 bits (443), Expect = 4e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248

Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305

Query: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365

Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 422

Query: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 423 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 474

Query: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 475 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 528

Query: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 529 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 588

Query: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 589 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 633

Query: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 634 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 688

Query: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 689 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 728

Query: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 729 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 784

Query: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 785 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 842

Query: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 843 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score =  214 bits (545), Expect = 5e-55
 Identities = 225/858 (26%), Positives = 339/858 (39%), Gaps = 85/858 (9%)

Query: 26  DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
           D+ P  V+ P D+I    S  +   LNC+  G P P+  W + G  ++ + D    +R  
Sbjct: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151

Query: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
           L  G+     I+       D G Y C+A N +G  +S  A+L+ A L +   +  S V V
Sbjct: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207

Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 199
             G+  V+ C PP   PE   SW  +  P    +D    I+   G L I+  + SD G Y
Sbjct: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267

Query: 200 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 249
           +C+  N V      S    LT+         E    V  P  +      + + +C A G+
Sbjct: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327

Query: 250 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
           PVPT+ W K +G +P      +    L+I  V   D G Y C AEN  GK      L V 
Sbjct: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387

Query: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
                PH+V K  D  +  G  + ++C+ATG P+P   W + G         P    SR 
Sbjct: 388 T---YPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRV 436

Query: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
            +   G L I NV +SD G Y C   N  G+I   A L+   ++A  P   + Q      
Sbjct: 437 EM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTII 492

Query: 430 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTC 489
           V  D   V+ C   GSP PTI W+K G     ++ RI  L +G L+I  A   D G+Y C
Sbjct: 493 VTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVC 551

Query: 490 IASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL 549
                 G A   A + V+E            P  I   P + E+T     ++ L+ +   
Sbjct: 552 RGENVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIH 597

Query: 550 NSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDP 609
           ++    T Y                 E+++ + S+   +  N     L+  A  YG    
Sbjct: 598 DASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG---- 649

Query: 610 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ 669
                  + Q    +        V+   G   + +      S++++      D  S  I 
Sbjct: 650 ------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-IS 702

Query: 670 GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--S 727
            Y +  R   +   ++   V E+ T    S +  DL   V YE +     N     D  +
Sbjct: 703 SYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPST 761

Query: 728 EIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETR 787
             +  +T E  P   P    VS   G    ++++W+P  E+ QNG    Y V    N TR
Sbjct: 762 PSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTR 819

Query: 788 YHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP 841
               K V  S  S  I      P L P   + V+V      G G  S+   I   A G P
Sbjct: 820 GWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEP 875

Query: 842 -VSPEDQVSLAQQISDVV 858
             +P D  + +  +S+++
Sbjct: 876 SAAPTDVKATSVSVSEIL 893



 Score =  175 bits (443), Expect = 4e-43
 Identities = 205/767 (26%), Positives = 304/767 (39%), Gaps = 107/767 (13%)

Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152
           D G Y+C+ +N +  A   +    + +  D              P  V  A G    MEC
Sbjct: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322

Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
               G+P PTI+W K    +  K  R+      L I   +  DAG Y C   N  G + S
Sbjct: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379

Query: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271
              +L V   P +V++ ++  +       ++C+A G P PT RW K+   L P+SR E+ 
Sbjct: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439

Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ--VVALG 329
           +   L I  V   D G Y C+AEN  G   ASA L +   +  P F +    +  +V   
Sbjct: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASA--PTFALNQLKKTIIVTKD 496

Query: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389
           + V  +C+  G+P+P I W++          +  + + R ++   G L I N  +SD G 
Sbjct: 497 QEVVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGK 548

Query: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPV 447
           Y+C+  NV GS    A L V +      P  I   P    + V  + VL+C A    S  
Sbjct: 549 YVCRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLD 602

Query: 448 PTILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 501
            T  W   G  +  ++      S   Q  +  L IR   L   GRY C   T +   +  
Sbjct: 603 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDE 662

Query: 502 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 561
           A + V+       PP P         P    V +++ +T TLSW P  ++ +  +SY ++
Sbjct: 663 AELLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQ 707

Query: 562 AFSHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQI 612
           A S  S   WQT    VKT    I G         L P   Y F V A N  G  DPS  
Sbjct: 708 ARSPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTP 762

Query: 613 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ 669
           S  ++T + +P +                     PT +S  S   H  V   +  S+  Q
Sbjct: 763 SRMIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQ 802

Query: 670 -----GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEF 722
                GY + +RP+G       W    V +   +  +  D  +     +E+K   + N+ 
Sbjct: 803 NGEGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKG 858

Query: 723 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-C 781
            G  S+I    + E  PSA P    V     + + ILV+W+   E        E   W  
Sbjct: 859 DGPFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKD 916

Query: 782 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 828
           +  E      KT    +F V++  L     Y   V A  GAG G  S
Sbjct: 917 MEQEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962



 Score =  129 bits (325), Expect = 2e-29
 Identities = 190/794 (23%), Positives = 311/794 (39%), Gaps = 110/794 (13%)

Query: 80  RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 136
           R+   S S  F      R S P  G     + ++LG A ++ + + +    D F+Q+   
Sbjct: 36  RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95

Query: 137 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 183
                    P D++       +   + C+  RG+P P+  W ++G+ +D + D R ++  
Sbjct: 96  DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154

Query: 184 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
           G  +I+  +   D+G Y C+ TN VG   S  A L      +F  R +  AV+V +    
Sbjct: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213

Query: 243 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 295
                  P  P + +     E P        R+  ++   L I KV   D+GSY C+ +N
Sbjct: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273

Query: 296 MVGKAEASATLT--------VQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 347
            V  A   +  T        V    EP   V  P     A G TV  +C A GNP P I 
Sbjct: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333

Query: 348 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 407
           W +      +  Y P  S +R   SQ   L I NVQ  D G Y C+  N  G    +  L
Sbjct: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384

Query: 408 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 466
           +V        P  + +  +N T    G+     C ATG P PT  W K+GV +S Q SR+
Sbjct: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436

Query: 467 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 526
            ++ NGVL I      D G Y C+A    G    SA +++                 + S
Sbjct: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478

Query: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 581
           AP+     +  + T+ ++    +     P        S   G   + V EN +       
Sbjct: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534

Query: 582 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 641
           +  I     +    ++ R  N +G    ++I   +  ++  PT   +  K+ +  +G ++
Sbjct: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589

Query: 642 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 699
             + N   +  +S++V  +WT       ++G  I +   G +               +N 
Sbjct: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640

Query: 700 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 759
           +++   R G   +            ADS    A+ L   P  PP G+ + +     TA L
Sbjct: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689

Query: 760 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 816
            SW P  ++     +  +Q    + LG +T   + + + G   S +   L P + Y   V
Sbjct: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748

Query: 817 AASTGAGSGVKSEP 830
            A+   G+G  S P
Sbjct: 749 VATNPIGTGDPSTP 762


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  207 bits (526), Expect = 9e-53
 Identities = 217/781 (27%), Positives = 355/781 (45%), Gaps = 104/781 (13%)

Query: 85  SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL---EVAILRDDFR------- 134
           +G+L+  ++      + D G Y CV  N     V+++  L      ILR+D         
Sbjct: 176 TGNLYIAKV-----EKSDVGNYTCVVTN----TVTNHKVLGPPTPLILRNDGVMGEYEPK 226

Query: 135 ---QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITY 190
              Q P  V  A G    +EC    G+P PTI W++ DG P+  K  R     G L I  
Sbjct: 227 IEVQFPETVPTAKGATVKLECFA-LGNPVPTIIWRRADGKPIARKARRHK-SNGILEIPN 284

Query: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
            ++ DAG Y CV  N  G+  +   +LT   +P+++++ +++ V ++++  ++C+A G P
Sbjct: 285 FQQEDAGLYECVAENSRGKNVAR-GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRP 343

Query: 251 VPTVRWRKDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
            PT +W K+ GE  L + R +I +  TL I  V   D G Y C+AEN  G   ++A L+V
Sbjct: 344 KPTYKWLKN-GEPLLTRDRIQI-EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSV 401

Query: 309 -QVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 367
             VG +    ++K R  +V +G  V  +C+   +P+P   W++   +++L      + + 
Sbjct: 402 IAVGPDFSRTLLK-RVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDIL------KENE 452

Query: 368 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 427
           R ++S+ G+L I NV +SD G Y C   N  G+  +   L V D      P  +   P +
Sbjct: 453 RITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD------PTRVMVPPSS 506

Query: 428 QTVAVDGTFVLSCVATGSPVPTIL--WRKDGVLVSTQDS-----RIKQLEN-GVLQIRYA 479
             V V  + VL C  T      I+  W  +G L+          R+   ++ G L IR  
Sbjct: 507 MDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNI 566

Query: 480 KLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRN 539
           +L   G+Y C+  T     + +A + V+       PP P      P A +  E+TD    
Sbjct: 567 QLKHAGKYVCMVQTSVDRLSAAADLIVRG------PPGP------PEAVTIDEITDT--- 611

Query: 540 TVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIY 594
           T  LSW+P  ++ +  T Y+I+A +  S   WQ V+      + KT T+ + GL P   Y
Sbjct: 612 TAQLSWRPGPDNHSPITMYVIQARTPFS-VGWQAVSTVPELIDGKTFTATVVGLNPWVEY 670

Query: 595 LFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSS 654
            F   AAN  GI +PS+ S+  +T++ LP    V    V    G            S S 
Sbjct: 671 EFRTVAANVIGIGEPSRPSEKRRTEEALPE---VTPANVSGGGG------------SKSE 715

Query: 655 IEVHW-TVDQQSQYIQ--GYKILYRPSGANHGESDWLVFEVRTPAKNSVVI--PDLRKGV 709
           + + W TV ++ Q  +  GY + +RP    +G+  W++  + +   +  V     +    
Sbjct: 716 LVITWETVPEELQNGRGFGYVVAFRP----YGKMIWMLTVLASADASRYVFRNESVHPFS 771

Query: 710 NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 769
            +E+K   F N+ +G  S      + EE P+ PP   ++     + T I V W  P E  
Sbjct: 772 PFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPP--ASIFARSLSATDIEVFWASPLEKN 829

Query: 770 QNGMVQEYKVWCLGNETRYHINKTVD--GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVK 827
           + G +Q Y+V    +E +    + +   G+  S  I  L   + Y + V A   AG+G  
Sbjct: 830 R-GRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPS 888

Query: 828 S 828
           S
Sbjct: 889 S 889



 Score =  202 bits (515), Expect = 2e-51
 Identities = 220/866 (25%), Positives = 344/866 (39%), Gaps = 109/866 (12%)

Query: 13  LICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERV 69
           ++CL   S L      P  ++ PS ++    S+ +   LNC+ +G P P I W   G  V
Sbjct: 14  ILCLADDSTLHG----PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDV 69

Query: 70  ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 129
           +T  D     R  +  GSL    +++      D G Y C A N  G  VS  A L+ A L
Sbjct: 70  DTGMD----FRYSVVEGSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYL 121

Query: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGGKLMI 188
            +   +  S V V  G+  V+ C PP    E + +W  +  P   D    ++   G L I
Sbjct: 122 DNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181

Query: 189 TYTRKSDAGKYVCVGTNMVGERESEVAELTVLER---------PSF-VKRPSNLAVTVDD 238
               KSD G Y CV TN V   +       ++ R         P   V+ P  +      
Sbjct: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGA 241

Query: 239 SAEFKCEARGDPVPTVRWRKDDGE-LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
           + + +C A G+PVPT+ WR+ DG+ + +     + +  L+I      D G Y CVAEN  
Sbjct: 242 TVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSR 301

Query: 298 GKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 357
           GK  A   LT       P+++ K  D  VA+   V ++C+A G P+P   W + G     
Sbjct: 302 GKNVARGQLTFYA---QPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNG----- 353

Query: 358 FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
              +P  +  R  + Q G L IT V  SD G Y C   N  G I + A L V  V  D  
Sbjct: 354 ---EPLLTRDRIQIEQ-GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFS 409

Query: 418 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
             ++++  +   V V G  V+ C    SP P   W+K G  +  ++ RI   E+G L+I 
Sbjct: 410 RTLLKRVTL---VKVGGEVVIECKPKASPKPVYTWKK-GRDILKENERITISEDGNLRII 465

Query: 478 YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS 537
                D G YTCIA+   G A+ +  + V++    + PP   D  +  S     +VT   
Sbjct: 466 NVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDH 525

Query: 538 RNTVTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYL 595
              +  +W  + N          + F    G  S+   +  N++        LK    Y+
Sbjct: 526 SLDIVFTW--SFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQ--------LKHAGKYV 575

Query: 596 FLVR-------AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPT 648
            +V+       AA    +  P    + V   ++  T+  +  +          +++    
Sbjct: 576 CMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV---- 631

Query: 649 VLSSSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRK 707
           + + +   V W  V    + I G        G N     W+ +E RT A N + I +   
Sbjct: 632 IQARTPFSVGWQAVSTVPELIDGKTFTATVVGLN----PWVEYEFRTVAANVIGIGE--- 684

Query: 708 GVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPE 767
                  +RP         SE +  +T E  P   P    VS   G+ + ++++W+  PE
Sbjct: 685 ------PSRP---------SEKR--RTEEALPEVTP--ANVSGGGGSKSELVITWETVPE 725

Query: 768 DTQNGMVQEY---------KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAA 818
           + QNG    Y          +W L       +  + D S +      + P   + V+V  
Sbjct: 726 ELQNGRGFGYVVAFRPYGKMIWML------TVLASADASRYVFRNESVHPFSPFEVKVGV 779

Query: 819 STGAGSGVKSEPQFIQLDAHGNPVSP 844
               G G  S P  +   A   P  P
Sbjct: 780 FNNKGEGPFS-PTTVVYSAEEEPTKP 804


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  205 bits (521), Expect = 3e-52
 Identities = 149/484 (30%), Positives = 217/484 (44%), Gaps = 40/484 (8%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
            P +   PS +     E   L C+A G P PTI W K G  V T          +LP G L
Sbjct: 2666 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2720

Query: 89   FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
               RI H   S  D G Y+C+A+N  G A+       V  +         D+    G  A
Sbjct: 2721 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2773

Query: 149  VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 207
             + C+  RG PEP I+W KDG P+   + + TI+  G+L++      DAG Y C   N V
Sbjct: 2774 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832

Query: 208  GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
            G     V  LT+L  P F   P + ++ + D    +C ARG P P + W  +D  + +  
Sbjct: 2833 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2891

Query: 268  YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ----VGSEPPHFVVKPRD 323
             E     TL+   V+  D G+Y C AEN VG+ +A + + V+    +  E   ++V+P  
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP-- 2949

Query: 324  QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383
                +G ++   C   G+P P I W ++G         P + S      Q G LTI   +
Sbjct: 2950 ----VGGSIQLDCVVRGDPVPDIHWIKDG--------LPLRGSHLRHQLQNGSLTIRRTE 2997

Query: 384  RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 443
            R D G Y C   N  G  + K  +    ++  +  PV +  P + TV       L C AT
Sbjct: 2998 RDDAGRYQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3051

Query: 444  GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 503
            G P PTI W + G  +     R++ L +G L +   + GD G Y C+A    G AT  A+
Sbjct: 3052 GEPTPTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF 3110

Query: 504  IEVQ 507
            + V+
Sbjct: 3111 LVVR 3114



 Score =  188 bits (478), Expect = 3e-47
 Identities = 161/515 (31%), Positives = 223/515 (43%), Gaps = 56/515 (10%)

Query: 28   PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            PP I    +    L+   GE  T+ C   G P   + W K G  +      P S R LL 
Sbjct: 2028 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2080

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 141
             GS   LRI   +    D G++ CVA +  G A   N +L+V +   L     QN  DV+
Sbjct: 2081 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2135

Query: 142  VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
            V  G    + C+  RG P P +SW KDG PL  +      +G  L +      D+G Y C
Sbjct: 2136 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2191

Query: 202  VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
            V  +  GE      +LTV+E P      +P+ L++T     E  C+A+G P P + W KD
Sbjct: 2192 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2250

Query: 260  DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ-----VGSEP 314
               L +     R    L++R     D G YTC+AE+  G  E S  + VQ     VG   
Sbjct: 2251 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRG 2305

Query: 315  PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
            P FVV      +A G+ V  +C     P P I W R+G      ++       RF     
Sbjct: 2306 PRFVVG-----LAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF----- 2354

Query: 375  GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
              L +  +  +D G Y C   N AGS      +E+  V      P IR GP    V+V+ 
Sbjct: 2355 --LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQ 2406

Query: 435  TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
            T +L C A G P P + WRKD V +  +  R + L  G L+I+     D G Y C+AS  
Sbjct: 2407 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2466

Query: 495  SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 529
            +G       + V E   P   P P++  L    P+
Sbjct: 2467 AGSDRQGRDLRVLE--PPAIAPSPSNLTLTAHTPA 2499



 Score =  181 bits (458), Expect = 7e-45
 Identities = 156/545 (28%), Positives = 231/545 (42%), Gaps = 59/545 (10%)

Query: 28   PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I +   P++L ++ G P  L C A+G P P I W+K G+ +   +++ R+ R+L   
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2270

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
                            D G+Y C+A +  G       S  V +        P      VG
Sbjct: 2271 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 2311

Query: 146  ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 201
                  V+EC      P P I+W +DG  L +D   +   RG  L +     +D+G Y C
Sbjct: 2312 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 2370

Query: 202  VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
               N  G   S    + +   P+    P  + V+V+ +A   C+A G P P V WRKD  
Sbjct: 2371 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 2429

Query: 262  EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
             L P+S R+EI  + +L+I+ V A D G Y C+A N  G       L V    EPP    
Sbjct: 2430 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL---EPPAIAP 2486

Query: 320  KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
             P +  +         CEA+G+P+P + W ++G Q L F  Q       + +  +  L +
Sbjct: 2487 SPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLL 2541

Query: 380  TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
            T     D   + C   N  G    + Y     V     PP I     + TV +    VL+
Sbjct: 2542 TAPGPQDSAQFECVVSNEVGEA-HRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLT 2595

Query: 440  CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
            C +TG P PT+ W K G  +  + S  +   +G L+I  A     GRYTC A   +G A 
Sbjct: 2596 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2655

Query: 500  WSAYIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
               ++ VQ    PV  P P+       +  L+P      E + + R T+T  WQ    + 
Sbjct: 2656 KHVFLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNV 2706

Query: 553  ATPTS 557
            AT  S
Sbjct: 2707 ATGVS 2711



 Score =  179 bits (453), Expect = 3e-44
 Identities = 145/480 (30%), Positives = 201/480 (41%), Gaps = 35/480 (7%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I   P +  V +    TL C A G P P + W+KG + V        S   +  S  
Sbjct: 603  PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 655

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
               LRI   + S  D G Y CVA N  G +      L V +             V V  P
Sbjct: 656  GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 712

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 204
              + C    G P PT+ W KDG+P+        ++   G  L +   R SD+G+Y CV  
Sbjct: 713  VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 771

Query: 205  NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 263
            + VGE   +V  L V   PS +    N++V  ++S   +C++   P P + W KD   L 
Sbjct: 772  SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 830

Query: 264  PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPR 322
            P+    +  D  L ++ +    D G YTC A N  G +E    L V V    P  + +  
Sbjct: 831  PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP--LRESH 888

Query: 323  DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITN 381
               V  G      CE  G P P I WR++G         P + +    VS  G L  +  
Sbjct: 889  TLTVREGHPTRLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQ 942

Query: 382  VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVL 438
             Q +  G Y C+  NV G+      LEV        PP I   R+ P   +V  DG   L
Sbjct: 943  AQLAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATL 996

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
             C ATG P PT+ W +DG  V  +     Q +   L +  A+   TGRY+C+A   +G A
Sbjct: 997  ECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056



 Score =  175 bits (444), Expect = 3e-43
 Identities = 156/511 (30%), Positives = 221/511 (43%), Gaps = 53/511 (10%)

Query: 35   PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
            P D ++V  G+ A L+C+ +  P PT+ WYK G+ +             L  G    L I
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQR--LEI 1808

Query: 94   VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
               + S  D+G+Y C   N  GEAV    +L V +           V    G P V+ C 
Sbjct: 1809 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1865

Query: 154  PPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
               G P PT++W KD  P++      +  RGG+L ++  + + AG Y CV  N   E   
Sbjct: 1866 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 1924

Query: 213  EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 263
            +   + VL  P    R S +A    V         CEA G P P V W KD   L     
Sbjct: 1925 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 1981

Query: 264  PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323
            P  R+ + D  +L ++ + A D G+YTCVA N  G+     T+ V V             
Sbjct: 1982 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGT 2040

Query: 324  QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNV 382
             V   G  VT  C   G+P   + W ++G         P   S R  +  +G  L I+ V
Sbjct: 2041 LVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISKV 2092

Query: 383  QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV-L 438
            Q +D G + C   + AG       L+V      + PPV+   PV   N  V V G+ V L
Sbjct: 2093 QLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVEL 2144

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGE 497
             C A G P+P + W KDG  + +Q      LE G  LQ+     GD+G Y+C+A + +GE
Sbjct: 2145 PCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGE 2199

Query: 498  ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 528
            A     + V E        +PT+ +L P AP
Sbjct: 2200 ARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2230



 Score =  175 bits (443), Expect = 4e-43
 Identities = 143/518 (27%), Positives = 216/518 (41%), Gaps = 44/518 (8%)

Query: 1    MIAEPAHFYLFGLICLCS---GSRLRQEDF----PPRIVEHPSDLIVSKGEPATLNCKAE 53
            ++A+ A  YL    CL S   GS  +  D     PP I   PS+L ++   PA L C+A 
Sbjct: 2451 VLAQDAGHYL----CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2506

Query: 54   GRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNY 113
            G P P + W+K G++++      +    LLPS +L             D   + CV  N 
Sbjct: 2507 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTA-----PGPQDSAQFECVVSNE 2559

Query: 114  LGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD 173
            +GEA  H        +      + +D  V +  P V+ C    G P PT+SW K G+ L 
Sbjct: 2560 VGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST-GIPAPTVSWSKAGAQLG 2616

Query: 174  DKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNL 232
             +     +   G L I       AG+Y C   N  G     V  LTV   P     PS +
Sbjct: 2617 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF-LTVQASPVVKPLPSVV 2675

Query: 233  AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTC 291
                ++     CEA G P PT+ W+K+   +      ++     L+I   +  D G+Y C
Sbjct: 2676 RAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 2735

Query: 292  VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
            +A+N  G A     L VQV   PP       D     G      C+A G+P+P I W ++
Sbjct: 2736 IAKNSAGSAMGKTRLVVQV---PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD 2792

Query: 352  GSQNLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT 410
            G        QP   +  +F++  +G+L + N++  D G Y C   N  G    + +L + 
Sbjct: 2793 G--------QPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL 2844

Query: 411  DVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 470
             +      PV    P ++++ +     L C A GSP P I W  +   V+   S  +Q  
Sbjct: 2845 VL------PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS--EQDG 2896

Query: 471  NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 508
               LQ       D+G Y C A    G     +++ V+E
Sbjct: 2897 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE 2934



 Score =  174 bits (440), Expect = 8e-43
 Identities = 147/492 (29%), Positives = 213/492 (43%), Gaps = 47/492 (9%)

Query: 24   QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
            Q   PP I+    ++ V   E   L C++   P P + W+K G  +E     PR    L 
Sbjct: 784  QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 838

Query: 84   PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
               +L  +     R    D G Y C A N  G +  H  +L V +      +    + V 
Sbjct: 839  ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKH-YNLNVWVAPVFPLRESHTLTVR 893

Query: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 200
             G P  + C+  RG P P ISW+KDG PL  +    + ++  G  L +   + +  G Y 
Sbjct: 894  EGHPTRLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 952

Query: 201  CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
            C  +N+VG   S+  +L V   P      + P+ ++V  D  A  +C A G P PTV W 
Sbjct: 953  CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 1011

Query: 258  KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
            + DG+   +   ++      +L + +  A   G Y+CVAEN+ G+AE    L+V V   P
Sbjct: 1012 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLV---P 1067

Query: 315  PHFV--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
            P  +  + P   +  AL   +T  CEA G P PAI W         F  + P S    + 
Sbjct: 1068 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTY 1118

Query: 372  SQTGD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
               G   L +T  Q  D G Y C   N AG       +EV        PP I    + + 
Sbjct: 1119 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEV 1172

Query: 430  VAV-DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
            + V DG T  L C  TG P P + W KDG  ++  D+     +  +LQ+  A L   G Y
Sbjct: 1173 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHY 1232

Query: 488  TCIASTPSGEAT 499
            +CIA+   GE T
Sbjct: 1233 SCIAANAVGEKT 1244



 Score =  169 bits (428), Expect = 2e-41
 Identities = 151/556 (27%), Positives = 231/556 (41%), Gaps = 68/556 (12%)

Query: 28   PPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            PP+I    E P+ + V +   ATL C A G+P PT+ W + G+ V  +         L  
Sbjct: 973  PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 1027

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD----V 140
             G    +     R      G Y CVA N  G A       E+++L         D    +
Sbjct: 1028 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSVLVPPELIGDLDPLTNI 1080

Query: 141  MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG-KLMITYTRKSDAGKY 199
              A+  P  + C+   G P P I W +   P+   ++   + GG  L +T T++ D+G Y
Sbjct: 1081 TAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLY 1139

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAEFKCEARGDPVPTVRWR 257
             C+ +N  GE     + + VL  PS         + V D  +A   C   G P P + W 
Sbjct: 1140 SCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF 1198

Query: 258  KDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
            KD   L +  + +   D   L++ +      G Y+C+A N VG+      L+V +     
Sbjct: 1199 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 1258

Query: 316  HFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                   D+   V +   ++  CEA   P P I W ++G+        P ++S    +  
Sbjct: 1259 GGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLP 1310

Query: 374  -TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--- 429
             T  L I N Q+ D G Y C   N  G  +   ++EV       PP + +  P+ +    
Sbjct: 1311 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLAEVGVK 1365

Query: 430  ---VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTG 485
                 V+ T  L C +   P PTI W KDG  V T  SR++ L  G +LQI+  ++ D+G
Sbjct: 1366 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQIQPTQVSDSG 1424

Query: 486  RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
            RY C+A+  +GE       + Q+F V +Q P           P   +V D S     LS 
Sbjct: 1425 RYLCVATNVAGE-------DDQDFNVLIQVP-----------PMFQKVGDFSAAFEILSR 1466

Query: 546  QPNLNSGATPTSYIIE 561
            +     G T    I+E
Sbjct: 1467 EEEARGGVTEYREIVE 1482



 Score =  168 bits (425), Expect = 4e-41
 Identities = 127/388 (32%), Positives = 176/388 (45%), Gaps = 35/388 (9%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I     DL  ++G  A L CKA G P P I W K G+ V            + PSG 
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV----SGAEGKFTIQPSGE 2810

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
            L  ++ + G+    D G Y C A N +G A      L + +L   F   P D  + +G+ 
Sbjct: 2811 L-LVKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2863

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
              + C   RG P P I W  +  P+ +        G  L      + D+G YVC   N V
Sbjct: 2864 LWLRC-AARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWAENRV 2921

Query: 208  GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
            G  ++     V E  VL+  +F    S L   V  S +  C  RGDPVP + W KD   L
Sbjct: 2922 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 2977

Query: 264  PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
              S  R+++++  +L IR+    D G Y C+AEN +G A+    L +Q     P F V+P
Sbjct: 2978 RGSHLRHQLQNG-SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQ---SAPVFQVEP 3033

Query: 322  RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
            +D  V  G  V  +C+ATG P P I W + G        QP ++S R      G L + N
Sbjct: 3034 QDMTVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLEN 3085

Query: 382  VQRSDVGYYICQTLNVAGSIITKAYLEV 409
            V+  D G Y C   N+ GS   +A+L V
Sbjct: 3086 VETGDAGTYDCVAHNLLGSATARAFLVV 3113



 Score =  160 bits (406), Expect = 7e-39
 Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 66/519 (12%)

Query: 28   PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I     + ++    G+ A L C   G P P + W+K G  +        +H  + P 
Sbjct: 1161 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1215

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 142
            G L  L+++    S    G Y C+A N +GE   H   +  L   IL         +V V
Sbjct: 1216 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1271

Query: 143  AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 201
             V  P  + C+     P P I+W KDG+P +       + G   L I   +K DAG+Y C
Sbjct: 1272 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1330

Query: 202  VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 254
            V TN +GE       + VL  PS  K           +   V+ +   +CE+   P PT+
Sbjct: 1331 VVTNELGEAVKNY-HVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTI 1389

Query: 255  RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-- 310
            RW KD   + P SR ++  +   L+I+     D G Y CVA N+ G+ +    + +QV  
Sbjct: 1390 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1449

Query: 311  -----GSEPPHFVVKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 355
                 G     F +  R++    G T              C+    P P + W RE    
Sbjct: 1450 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 1506

Query: 356  LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 414
                 QP  +    SV Q G  L I  V+  + G Y C+  N  G       L V     
Sbjct: 1507 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1558

Query: 415  DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 469
               PPVI  G   +     TV    T  L C A G+PVPTI W ++G L  +   R++ L
Sbjct: 1559 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 1613

Query: 470  ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
            E+G VLQ+  A++ D   Y C+A   +G A     + VQ
Sbjct: 1614 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1652



 Score =  159 bits (401), Expect = 3e-38
 Identities = 146/510 (28%), Positives = 207/510 (40%), Gaps = 55/510 (10%)

Query: 28  PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV-----------ETDKD 74
           PP I E      VS   G+  TL C A G P P I W K  + V           +    
Sbjct: 16  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75

Query: 75  DPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR 134
               HR+L    SL F RI  G     D G+Y C A N  G A      L +        
Sbjct: 76  QVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 130

Query: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR--GGKLMITYTR 192
               +V+   G    ++C    G P P + W KD  P+      + ++  G  L IT + 
Sbjct: 131 GAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSH 189

Query: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDP 250
             D G+Y CV  +  G++  +  +L V   P+         +AV  D   +  CEARG P
Sbjct: 190 VGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 248

Query: 251 VPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
            P + W KD   LP S   +  R    L++ +  + D G YTC A N VG AE +  L V
Sbjct: 249 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308

Query: 309 QV-----GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
            V     G+    +VVK        GR V  +C A G+P P + W  EG         P 
Sbjct: 309 YVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGHPSPTLSWHHEGL--------PV 355

Query: 364 QSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP--V 420
             S+   +   G  L + +   +  G Y C   + AG  + +  +EV      + PP  +
Sbjct: 356 AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV------QVPPQLL 409

Query: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
           + +G    T  V     L C A+GSPVPTI W ++G             +   L I + +
Sbjct: 410 VAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVE 469

Query: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFG 510
           L  +G + C A+  +G A   A +EV   G
Sbjct: 470 LDHSGLFACQATNEAGTA--GAEVEVSVHG 497



 Score =  159 bits (401), Expect = 3e-38
 Identities = 130/475 (27%), Positives = 193/475 (40%), Gaps = 48/475 (10%)

Query: 40   VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 96
            + +  PA L C     P P + WY+        +D P S      +L  G +  + +V  
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 1531

Query: 97   RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 154
              +    G Y C A N +GE   H   L +   ++  D  +   +V V       ++C P
Sbjct: 1532 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 1586

Query: 155  PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 213
              G+P PTISW ++G P         +  G+ L ++    +DA  Y+CV  N  G  E +
Sbjct: 1587 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 1645

Query: 214  VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 270
            +  L V   P         +   ++ S    C+    P P V W KD   L      + +
Sbjct: 1646 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 1705

Query: 271  RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ----VV 326
               HTL++ +    D G YTC A N  G+ +    L+V V   PP F   PR      +V
Sbjct: 1706 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLV 1762

Query: 327  ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRS 385
             +G      CE    P+P + W ++G        QP   + R    + G  L I   Q S
Sbjct: 1763 RVGDKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVS 1814

Query: 386  DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVAT 443
            D G Y C+  NVAG  +    L V      + PP   + P  +TV+       VL+C  +
Sbjct: 1815 DKGLYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVS 1867

Query: 444  GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
            G P PT+ W KD + V +          G LQ+   +    G YTC+A     EA
Sbjct: 1868 GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 1922



 Score =  157 bits (398), Expect = 6e-38
 Identities = 149/535 (27%), Positives = 216/535 (40%), Gaps = 42/535 (7%)

Query: 28  PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
           PP I       ++ V +     L C+A G PTP I W+K G  +      P S +++   
Sbjct: 218 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 271

Query: 86  GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 144
           G     ++  GR    D GVY C A N +G A  +    + V    +     P  V    
Sbjct: 272 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 328

Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 203
           G P  +EC   RGHP PT+SW  +G P+ + +E R+   G  L +    ++ +G Y CV 
Sbjct: 329 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 387

Query: 204 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 260
           ++  GE   + + E+ V  +    +    +   V    E  C+A G PVPT++W ++   
Sbjct: 388 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 447

Query: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK 320
            E            TL I  V     G + C A N  G A A   ++V  G   P  +  
Sbjct: 448 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH-GEWAPGVLEV 506

Query: 321 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQT 374
           P  Q    G        A  +P     W       L+  +  P S          + S  
Sbjct: 507 PIGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 565

Query: 375 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
             L I  V   D G Y C   N+AG    +  L+V        PP I  GPVN+ V  + 
Sbjct: 566 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENA 619

Query: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
           +  L C+A+G P P + W K    VS+       ++  VL+I  A+L D G Y C+AS  
Sbjct: 620 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNV 679

Query: 495 SGEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
           +G            +G+ V  PPR T P   PS P    V    R T   +  P+
Sbjct: 680 AGSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 724



 Score =  150 bits (379), Expect = 1e-35
 Identities = 149/522 (28%), Positives = 213/522 (40%), Gaps = 74/522 (14%)

Query: 32  VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
           V+ P  L+V++G         +P  L C+A G P PTI+W + G   E       +   +
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQV 456

Query: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
              G+   +  V    S    G++ C A N  G A    A +EV++  +     P  + V
Sbjct: 457 ASQGTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 506

Query: 143 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 184
            +G+           PA   C PP  RG   HP+P +   W   GS L  +   I +   
Sbjct: 507 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 563

Query: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
               L I      D G Y C  TN+ GE + EVA L VL  P+    P N AV  + S  
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 622

Query: 242 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
            +C A G P P V W K  G  P S +       D   L+I +    D GSY CVA N+ 
Sbjct: 623 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 680

Query: 298 GKAEASATLTVQVGSEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL 356
           G  E    L V V   PP   + P     V +   V   C ATG P P + W ++G+   
Sbjct: 681 GSTELRYGLRVNV---PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP-- 735

Query: 357 LFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD 415
                 P  +    V   G  LT+ + + SD G Y C  ++  G       L+V      
Sbjct: 736 ----VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------ 785

Query: 416 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ 475
             PP I    +N +V  + +  L C +   P P + W KDG  +  +       +  +LQ
Sbjct: 786 HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ 845

Query: 476 IRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 517
           +  A + D G YTC A   +G +    +  +  +  PV P R
Sbjct: 846 VDRADVWDAGHYTCEALNQAGHS--EKHYNLNVWVAPVFPLR 885



 Score =  138 bits (347), Expect = 5e-32
 Identities = 121/459 (26%), Positives = 191/459 (41%), Gaps = 38/459 (8%)

Query: 102  DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
            DEG+Y C A N  GE+     +L+V ++  +    P +  V       +EC    G P P
Sbjct: 577  DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 633

Query: 162  TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
             +SW K   P+       +++ G  L I   + SDAG Y CV +N+ G  E     L V 
Sbjct: 634  DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 692

Query: 221  ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 275
              P     PS    V V+      C A G P PT+ W KD   +  +             
Sbjct: 693  VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 752

Query: 276  LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQ 335
            L +    A D G Y+CVA + VG+      L V +   PP  + +  +  V    +V  +
Sbjct: 753  LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM---PPSILGEELNVSVVANESVALE 809

Query: 336  CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYIC 392
            C++   P P + W ++G               R  V  + D  +  V R+DV   G+Y C
Sbjct: 810  CQSHAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTC 859

Query: 393  QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 452
            + LN AG   ++ +  +   +A   P  +R+     TV       LSC   G P P I W
Sbjct: 860  EALNQAGH--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTRLSCECRGVPFPKISW 914

Query: 453  RKDGVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ--- 507
            RKDG  +  + + ++ +     +L +  A+L   G YTC  S   G ++    +EV    
Sbjct: 915  RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPP 974

Query: 508  EFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 546
            +   P +P  PT  +++    +  E     +   T++W+
Sbjct: 975  QIAGPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 1011



 Score =  120 bits (302), Expect = 8e-27
 Identities = 121/420 (28%), Positives = 173/420 (41%), Gaps = 50/420 (11%)

Query: 116 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKD----GSP 171
           E + +  S+    +R+D R+  ++V    G+   +EC    G P P I W KD    G P
Sbjct: 6   EPLLNTGSVVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFPVPEIVWLKDAQLVGVP 62

Query: 172 L------------DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
           L                 R+   G  L     ++ D+G Y C   N  G  + +   L V
Sbjct: 63  LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDF-HLLV 121

Query: 220 LERPSFVKRPSNLAVT--VDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRY-EIRDD-H 274
           L  PS +   +   V        E +C   G P P V W KD    LP   + ++++D  
Sbjct: 122 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ 181

Query: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----GSEPPHFVVKPRDQVVALG 329
            L+I     GD G Y CVA +  G+      L V       GS     V    D +V L 
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQL- 240

Query: 330 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 389
                 CEA G P P I W ++G+  LL     P S+          L +   Q SD G 
Sbjct: 241 -----LCEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRGGRQLQLGRAQSSDAGV 288

Query: 390 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AVDGTFV-LSCVATGSPV 447
           Y C+  N  G+      L+V       PP +   G     V AV G  V L CVA G P 
Sbjct: 289 YTCKASNAVGAAEKATRLDVYV-----PPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 343

Query: 448 PTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
           PT+ W  +G+ V+  +    + +  VL++       +G Y+C+AS+P+GEA     +EVQ
Sbjct: 344 PTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ 403


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  204 bits (520), Expect = 4e-52
 Identities = 149/484 (30%), Positives = 217/484 (44%), Gaps = 40/484 (8%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
            P +   PS +     E   L C+A G P PTI W K G  V T          +LP G L
Sbjct: 2757 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2811

Query: 89   FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
               RI H   S  D G Y+C+A+N  G A+       V  +         D+    G  A
Sbjct: 2812 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2864

Query: 149  VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 207
             + C+  RG PEP I+W KDG P+   + + TI+  G+L++      DAG Y C   N V
Sbjct: 2865 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923

Query: 208  GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
            G     V  LT+L  P F   P + ++ + D    +C ARG P P + W  +D  + +  
Sbjct: 2924 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2982

Query: 268  YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ----VGSEPPHFVVKPRD 323
             E     TL+   V+  D G+Y C AEN VG+ +A + + V+    +  E   ++V+P  
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP-- 3040

Query: 324  QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383
                +G ++   C   G+P P I W ++G         P + S      Q G LTI   +
Sbjct: 3041 ----VGGSIQLDCVVRGDPVPDIHWIKDG--------LPLRGSHLRHQLQNGSLTIHRTE 3088

Query: 384  RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 443
            R D G Y C   N  G  + K  +    ++  +  PV +  P + TV       L C AT
Sbjct: 3089 RDDAGRYQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 3142

Query: 444  GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 503
            G P PTI W + G  +     R++ L +G L +   + GD G Y C+A    G AT  A+
Sbjct: 3143 GEPTPTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF 3201

Query: 504  IEVQ 507
            + V+
Sbjct: 3202 LVVR 3205



 Score =  188 bits (478), Expect = 3e-47
 Identities = 161/515 (31%), Positives = 223/515 (43%), Gaps = 56/515 (10%)

Query: 28   PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            PP I    +    L+   GE  T+ C   G P   + W K G  +      P S R LL 
Sbjct: 2119 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2171

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 141
             GS   LRI   +    D G++ CVA +  G A   N +L+V +   L     QN  DV+
Sbjct: 2172 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2226

Query: 142  VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
            V  G    + C+  RG P P +SW KDG PL  +      +G  L +      D+G Y C
Sbjct: 2227 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2282

Query: 202  VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
            V  +  GE      +LTV+E P      +P+ L++T     E  C+A+G P P + W KD
Sbjct: 2283 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2341

Query: 260  DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ-----VGSEP 314
               L +     R    L++R     D G YTC+AE+  G  E S  + VQ     VG   
Sbjct: 2342 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRG 2396

Query: 315  PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
            P FVV      +A G+ V  +C     P P I W R+G      ++       RF     
Sbjct: 2397 PRFVVG-----LAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF----- 2445

Query: 375  GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
              L +  +  +D G Y C   N AGS      +E+  V      P IR GP    V+V+ 
Sbjct: 2446 --LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQ 2497

Query: 435  TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
            T +L C A G P P + WRKD V +  +  R + L  G L+I+     D G Y C+AS  
Sbjct: 2498 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 2557

Query: 495  SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 529
            +G       + V E   P   P P++  L    P+
Sbjct: 2558 AGSDRQGRDLRVLE--PPAIAPSPSNLTLTAHTPA 2590



 Score =  181 bits (458), Expect = 7e-45
 Identities = 145/480 (30%), Positives = 203/480 (42%), Gaps = 35/480 (7%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I   P +  V +    TL C A G P P + W+KG + V        S   +  S  
Sbjct: 694  PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 746

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
               LRI   + S  D G Y CVA N  G +      L V +             V V  P
Sbjct: 747  GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 803

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 204
              + C    G P PT+ W KDG+P+        ++   G  L +   R SD+G+Y CV  
Sbjct: 804  VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 862

Query: 205  NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 263
            + VGE   +V  L V   PS +    N++V  ++S   +C++   P P + W KD   L 
Sbjct: 863  SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 921

Query: 264  PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPR 322
            P+    +  D  L ++ +    D G YTC A N  G++E    L V V    P  + +  
Sbjct: 922  PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFP--LRESH 979

Query: 323  DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITN 381
               V  G   +  CE  G P P I WR++G         P + +    VS  G L  +  
Sbjct: 980  TLTVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQ 1033

Query: 382  VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVL 438
             Q +  G Y C+  NV G+      LEV        PP I   R+ P   +V  DG   L
Sbjct: 1034 AQLAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATL 1087

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
             C ATG P PT+ W +DG  V  +     Q +   L +  A+   TGRY+C+A   +G A
Sbjct: 1088 ECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147



 Score =  181 bits (458), Expect = 7e-45
 Identities = 156/545 (28%), Positives = 231/545 (42%), Gaps = 59/545 (10%)

Query: 28   PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I +   P++L ++ G P  L C A+G P P I W+K G+ +   +++ R+ R+L   
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2361

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
                            D G+Y C+A +  G       S  V +        P      VG
Sbjct: 2362 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 2402

Query: 146  ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 201
                  V+EC      P P I+W +DG  L +D   +   RG  L +     +D+G Y C
Sbjct: 2403 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 2461

Query: 202  VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
               N  G   S    + +   P+    P  + V+V+ +A   C+A G P P V WRKD  
Sbjct: 2462 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 2520

Query: 262  EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
             L P+S R+EI  + +L+I+ V A D G Y C+A N  G       L V    EPP    
Sbjct: 2521 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL---EPPAIAP 2577

Query: 320  KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
             P +  +         CEA+G+P+P + W ++G Q L F  Q       + +  +  L +
Sbjct: 2578 SPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLL 2632

Query: 380  TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
            T     D   + C   N  G    + Y     V     PP I     + TV +    VL+
Sbjct: 2633 TAPGPQDSAQFECVVSNEVGEA-HRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLT 2686

Query: 440  CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
            C +TG P PT+ W K G  +  + S  +   +G L+I  A     GRYTC A   +G A 
Sbjct: 2687 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2746

Query: 500  WSAYIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
               ++ VQ    PV  P P+       +  L+P      E + + R T+T  WQ    + 
Sbjct: 2747 KHVFLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNV 2797

Query: 553  ATPTS 557
            AT  S
Sbjct: 2798 ATGVS 2802



 Score =  175 bits (444), Expect = 3e-43
 Identities = 156/511 (30%), Positives = 221/511 (43%), Gaps = 53/511 (10%)

Query: 35   PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
            P D ++V  G+ A L+C+ +  P PT+ WYK G+ +             L  G    L I
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQR--LEI 1899

Query: 94   VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
               + S  D+G+Y C   N  GEAV    +L V +           V    G P V+ C 
Sbjct: 1900 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1956

Query: 154  PPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
               G P PT++W KD  P++      +  RGG+L ++  + + AG Y CV  N   E   
Sbjct: 1957 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 2015

Query: 213  EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 263
            +   + VL  P    R S +A    V         CEA G P P V W KD   L     
Sbjct: 2016 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 2072

Query: 264  PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323
            P  R+ + D  +L ++ + A D G+YTCVA N  G+     T+ V V             
Sbjct: 2073 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGT 2131

Query: 324  QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNV 382
             V   G  VT  C   G+P   + W ++G         P   S R  +  +G  L I+ V
Sbjct: 2132 LVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISKV 2183

Query: 383  QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV-L 438
            Q +D G + C   + AG       L+V      + PPV+   PV   N  V V G+ V L
Sbjct: 2184 QLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVEL 2235

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGE 497
             C A G P+P + W KDG  + +Q      LE G  LQ+     GD+G Y+C+A + +GE
Sbjct: 2236 PCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGE 2290

Query: 498  ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 528
            A     + V E        +PT+ +L P AP
Sbjct: 2291 ARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2321



 Score =  175 bits (443), Expect = 4e-43
 Identities = 143/518 (27%), Positives = 216/518 (41%), Gaps = 44/518 (8%)

Query: 1    MIAEPAHFYLFGLICLCS---GSRLRQEDF----PPRIVEHPSDLIVSKGEPATLNCKAE 53
            ++A+ A  YL    CL S   GS  +  D     PP I   PS+L ++   PA L C+A 
Sbjct: 2542 VLAQDAGHYL----CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2597

Query: 54   GRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNY 113
            G P P + W+K G++++      +    LLPS +L             D   + CV  N 
Sbjct: 2598 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTA-----PGPQDSAQFECVVSNE 2650

Query: 114  LGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD 173
            +GEA  H        +      + +D  V +  P V+ C    G P PT+SW K G+ L 
Sbjct: 2651 VGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST-GIPAPTVSWSKAGAQLG 2707

Query: 174  DKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNL 232
             +     +   G L I       AG+Y C   N  G     V  LTV   P     PS +
Sbjct: 2708 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF-LTVQASPVVKPLPSVV 2766

Query: 233  AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTC 291
                ++     CEA G P PT+ W+K+   +      ++     L+I   +  D G+Y C
Sbjct: 2767 RAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 2826

Query: 292  VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
            +A+N  G A     L VQV   PP       D     G      C+A G+P+P I W ++
Sbjct: 2827 IAKNSAGSAMGKTRLVVQV---PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD 2883

Query: 352  GSQNLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT 410
            G        QP   +  +F++  +G+L + N++  D G Y C   N  G    + +L + 
Sbjct: 2884 G--------QPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL 2935

Query: 411  DVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 470
             +      PV    P ++++ +     L C A GSP P I W  +   V+   S  +Q  
Sbjct: 2936 VL------PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS--EQDG 2987

Query: 471  NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 508
               LQ       D+G Y C A    G     +++ V+E
Sbjct: 2988 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE 3025



 Score =  174 bits (441), Expect = 6e-43
 Identities = 147/492 (29%), Positives = 213/492 (43%), Gaps = 47/492 (9%)

Query: 24   QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
            Q   PP I+    ++ V   E   L C++   P P + W+K G  +E     PR    L 
Sbjct: 875  QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 929

Query: 84   PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
               +L  +     R    D G Y C A N  G +  H  +L V +      +    + V 
Sbjct: 930  ADKALLQV----DRADVWDAGHYTCEALNQAGRSEKH-YNLNVWVAPVFPLRESHTLTVR 984

Query: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 200
             G P  + C+  RG P P ISW+KDG PL  +    + ++  G  L +   + +  G Y 
Sbjct: 985  EGHPTSLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 1043

Query: 201  CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
            C  +N+VG   S+  +L V   P      + P+ ++V  D  A  +C A G P PTV W 
Sbjct: 1044 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 1102

Query: 258  KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
            + DG+   +   ++      +L + +  A   G Y+CVAEN+ G+AE    L+V V   P
Sbjct: 1103 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLV---P 1158

Query: 315  PHFV--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
            P  +  + P   +  AL   +T  CEA G P PAI W         F  + P S    + 
Sbjct: 1159 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTY 1209

Query: 372  SQTGD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
               G   L +T  Q  D G Y C   N AG       +EV        PP I    + + 
Sbjct: 1210 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEV 1263

Query: 430  VAV-DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
            + V DG T  L C  TG P P + W KDG  ++  D+     +  +LQ+  A L   G Y
Sbjct: 1264 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHY 1323

Query: 488  TCIASTPSGEAT 499
            +CIA+   GE T
Sbjct: 1324 SCIAANAVGEKT 1335



 Score =  170 bits (430), Expect = 1e-41
 Identities = 151/556 (27%), Positives = 231/556 (41%), Gaps = 68/556 (12%)

Query: 28   PPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            PP+I    E P+ + V +   ATL C A G+P PT+ W + G+ V  +         L  
Sbjct: 1064 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 1118

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD----V 140
             G    +     R      G Y CVA N  G A       E+++L         D    +
Sbjct: 1119 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSVLVPPELIGDLDPLTNI 1171

Query: 141  MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG-KLMITYTRKSDAGKY 199
              A+  P  + C+   G P P I W +   P+   ++   + GG  L +T T++ D+G Y
Sbjct: 1172 TAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLY 1230

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAEFKCEARGDPVPTVRWR 257
             C+ +N  GE     + + VL  PS         + V D  +A   C   G P P + W 
Sbjct: 1231 SCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF 1289

Query: 258  KDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
            KD   L +  + +   D   L++ +      G Y+C+A N VG+      L+V +     
Sbjct: 1290 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 1349

Query: 316  HFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                   D+   V +   ++  CEA   P P I W ++G+        P ++S    +  
Sbjct: 1350 GGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLP 1401

Query: 374  -TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--- 429
             T  L I N Q+ D G Y C   N  G  +   ++EV       PP + +  P+ +    
Sbjct: 1402 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGEVGVK 1456

Query: 430  ---VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTG 485
                 V+ T  L C +   P PTI W KDG  V T  SR++ L  G +LQI+  ++ D+G
Sbjct: 1457 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQIQPTQVSDSG 1515

Query: 486  RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
            RY C+A+  +GE       + Q+F V +Q P           P   +V D S     LS 
Sbjct: 1516 RYLCVATNVAGE-------DDQDFNVLIQVP-----------PMFQKVGDFSAAFEILSR 1557

Query: 546  QPNLNSGATPTSYIIE 561
            +     G T    I+E
Sbjct: 1558 EEEARGGVTEYREIVE 1573



 Score =  166 bits (420), Expect = 2e-40
 Identities = 126/388 (32%), Positives = 175/388 (45%), Gaps = 35/388 (9%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I     DL  ++G  A L CKA G P P I W K G+ V            + PSG 
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV----SGAEGKFTIQPSGE 2901

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
            L  ++ + G+    D G Y C A N +G A      L + +L   F   P D  + +G+ 
Sbjct: 2902 L-LVKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2954

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
              + C   RG P P I W  +  P+ +        G  L      + D+G YVC   N V
Sbjct: 2955 LWLRC-AARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWAENRV 3012

Query: 208  GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
            G  ++     V E  VL+  +F    S L   V  S +  C  RGDPVP + W KD   L
Sbjct: 3013 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 3068

Query: 264  PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
              S  R+++++  +L I +    D G Y C+AEN +G A+    L +Q     P F V+P
Sbjct: 3069 RGSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ---SAPVFQVEP 3124

Query: 322  RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
            +D  V  G  V  +C+ATG P P I W + G        QP ++S R      G L + N
Sbjct: 3125 QDMTVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLEN 3176

Query: 382  VQRSDVGYYICQTLNVAGSIITKAYLEV 409
            V+  D G Y C   N+ GS   +A+L V
Sbjct: 3177 VETGDAGTYDCVAHNLLGSATARAFLVV 3204



 Score =  160 bits (406), Expect = 7e-39
 Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 66/519 (12%)

Query: 28   PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I     + ++    G+ A L C   G P P + W+K G  +        +H  + P 
Sbjct: 1252 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1306

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 142
            G L  L+++    S    G Y C+A N +GE   H   +  L   IL         +V V
Sbjct: 1307 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1362

Query: 143  AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 201
             V  P  + C+     P P I+W KDG+P +       + G   L I   +K DAG+Y C
Sbjct: 1363 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1421

Query: 202  VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 254
            V TN +GE       + VL  PS  K           +   V+ +   +CE+   P PT+
Sbjct: 1422 VVTNELGEAVKNY-HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 1480

Query: 255  RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-- 310
            RW KD   + P SR ++  +   L+I+     D G Y CVA N+ G+ +    + +QV  
Sbjct: 1481 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1540

Query: 311  -----GSEPPHFVVKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 355
                 G     F +  R++    G T              C+    P P + W RE    
Sbjct: 1541 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 1597

Query: 356  LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 414
                 QP  +    SV Q G  L I  V+  + G Y C+  N  G       L V     
Sbjct: 1598 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1649

Query: 415  DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 469
               PPVI  G   +     TV    T  L C A G+PVPTI W ++G L  +   R++ L
Sbjct: 1650 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 1704

Query: 470  ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
            E+G VLQ+  A++ D   Y C+A   +G A     + VQ
Sbjct: 1705 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1743



 Score =  159 bits (401), Expect = 3e-38
 Identities = 130/475 (27%), Positives = 193/475 (40%), Gaps = 48/475 (10%)

Query: 40   VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 96
            + +  PA L C     P P + WY+        +D P S      +L  G +  + +V  
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 1622

Query: 97   RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 154
              +    G Y C A N +GE   H   L +   ++  D  +   +V V       ++C P
Sbjct: 1623 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 1677

Query: 155  PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 213
              G+P PTISW ++G P         +  G+ L ++    +DA  Y+CV  N  G  E +
Sbjct: 1678 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 1736

Query: 214  VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 270
            +  L V   P         +   ++ S    C+    P P V W KD   L      + +
Sbjct: 1737 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 1796

Query: 271  RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ----VV 326
               HTL++ +    D G YTC A N  G+ +    L+V V   PP F   PR      +V
Sbjct: 1797 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLV 1853

Query: 327  ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRS 385
             +G      CE    P+P + W ++G        QP   + R    + G  L I   Q S
Sbjct: 1854 RVGDKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVS 1905

Query: 386  DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVAT 443
            D G Y C+  NVAG  +    L V      + PP   + P  +TV+       VL+C  +
Sbjct: 1906 DKGLYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVS 1958

Query: 444  GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
            G P PT+ W KD + V +          G LQ+   +    G YTC+A     EA
Sbjct: 1959 GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 2013



 Score =  157 bits (398), Expect = 6e-38
 Identities = 149/535 (27%), Positives = 216/535 (40%), Gaps = 42/535 (7%)

Query: 28  PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
           PP I       ++ V +     L C+A G PTP I W+K G  +      P S +++   
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 362

Query: 86  GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA-VSHNASLEVAILRDDFRQNPSDVMVAV 144
           G     ++  GR    D GVY C A N +G A  +    + V    +     P  V    
Sbjct: 363 GG---RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 419

Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 203
           G P  +EC   RGHP PT+SW  +G P+ + +E R+   G  L +    ++ +G Y CV 
Sbjct: 420 GRPVALEC-VARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478

Query: 204 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD--D 260
           ++  GE   + + E+ V  +    +    +   V    E  C+A G PVPT++W ++   
Sbjct: 479 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 538

Query: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK 320
            E            TL I  V     G + C A N  G A A   ++V  G   P  +  
Sbjct: 539 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH-GEWAPGVLEV 597

Query: 321 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQT 374
           P  Q    G        A  +P     W       L+  +  P S          + S  
Sbjct: 598 PIGQ-YHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 656

Query: 375 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
             L I  V   D G Y C   N+AG    +  L+V        PP I  GPVN+ V  + 
Sbjct: 657 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENA 710

Query: 435 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
           +  L C+A+G P P + W K    VS+       ++  VL+I  A+L D G Y C+AS  
Sbjct: 711 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNV 770

Query: 495 SGEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
           +G            +G+ V  PPR T P   PS P    V    R T   +  P+
Sbjct: 771 AGSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 815



 Score =  150 bits (379), Expect = 1e-35
 Identities = 150/522 (28%), Positives = 213/522 (40%), Gaps = 74/522 (14%)

Query: 32  VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
           V+ P  L+V++G         +P  L C+A G P PTI+W + G   E       +   +
Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAE-----ELAGVQV 547

Query: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
              G+   L I H        G++ C A N  G A    A +EV++  +     P  + V
Sbjct: 548 ASQGTT--LHIDHVELDH--SGLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 597

Query: 143 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 184
            +G+           PA   C PP  RG   HP+P +   W   GS L  +   I +   
Sbjct: 598 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 654

Query: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
               L I      D G Y C  TN+ GE + EVA L VL  P+    P N AV  + S  
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 713

Query: 242 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
            +C A G P P V W K  G  P S +       D   L+I +    D GSY CVA N+ 
Sbjct: 714 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 771

Query: 298 GKAEASATLTVQVGSEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL 356
           G  E    L V V   PP   + P     V +   V   C ATG P P + W ++G+   
Sbjct: 772 GSTELRYGLRVNV---PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP-- 826

Query: 357 LFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD 415
                 P  +    V   G  LT+ + + SD G Y C  ++  G       L+V      
Sbjct: 827 ----VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------ 876

Query: 416 RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ 475
             PP I    +N +V  + +  L C +   P P + W KDG  +  +       +  +LQ
Sbjct: 877 HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ 936

Query: 476 IRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 517
           +  A + D G YTC A   +G +    +  +  +  PV P R
Sbjct: 937 VDRADVWDAGHYTCEALNQAGRS--EKHYNLNVWVAPVFPLR 976



 Score =  145 bits (365), Expect = 4e-34
 Identities = 144/529 (27%), Positives = 206/529 (38%), Gaps = 80/529 (15%)

Query: 28  PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV-----------ETDKD 74
           PP I E      VS   G+  TL C A G P P I W K  + V           +    
Sbjct: 94  PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 153

Query: 75  DPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR 134
               HR+L    SL F RI  GR  R              G +    A     +    F 
Sbjct: 154 QVGGHRLLDEGQSLHFPRIQPGRSGRRGAQA---------GGSAQTKAPWXAGLA--GFE 202

Query: 135 QNPS-------------------DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 175
           Q P+                   +V+   G    ++C    G P P + W KD  P+   
Sbjct: 203 QFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPG 261

Query: 176 DERITIR--GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSN 231
              + ++  G  L IT +   D G+Y CV  +  G++  +  +L V   P+         
Sbjct: 262 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGE 320

Query: 232 LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSY 289
           +AV  D   +  CEARG P P + W KD   LP S   +  R    L++ +  + D G Y
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVY 380

Query: 290 TCVAENMVGKAEASATLTVQV-----GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQP 344
           TC A N VG AE +  L V V     G+    +VVK        GR V  +C A G+P P
Sbjct: 381 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGHPSP 435

Query: 345 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIIT 403
            + W  EG         P   S+   +   G  L + +   +  G Y C   + AG  + 
Sbjct: 436 TLSWHHEGL--------PVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVL 487

Query: 404 KAYLEVTDVIADRPPP--VIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST 461
           +  +EV      + PP  ++ +G    T  V     L C A+GSPVPTI W ++G     
Sbjct: 488 QYSVEV------QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE 541

Query: 462 QDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 510
                   +   L I + +L  +G + C A+  +G A   A +EV   G
Sbjct: 542 LAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA--GAEVEVSVHG 588



 Score =  138 bits (348), Expect = 4e-32
 Identities = 121/459 (26%), Positives = 191/459 (41%), Gaps = 38/459 (8%)

Query: 102  DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
            DEG+Y C A N  GE+     +L+V ++  +    P +  V       +EC    G P P
Sbjct: 668  DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 724

Query: 162  TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
             +SW K   P+       +++ G  L I   + SDAG Y CV +N+ G  E     L V 
Sbjct: 725  DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 783

Query: 221  ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 275
              P     PS    V V+      C A G P PT+ W KD   +  +             
Sbjct: 784  VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 843

Query: 276  LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQ 335
            L +    A D G Y+CVA + VG+      L V +   PP  + +  +  V    +V  +
Sbjct: 844  LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM---PPSILGEELNVSVVANESVALE 900

Query: 336  CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYIC 392
            C++   P P + W ++G               R  V  + D  +  V R+DV   G+Y C
Sbjct: 901  CQSHAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTC 950

Query: 393  QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 452
            + LN AG   ++ +  +   +A   P  +R+     TV       LSC   G P P I W
Sbjct: 951  EALNQAGR--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTSLSCECRGVPFPKISW 1005

Query: 453  RKDGVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ--- 507
            RKDG  +  + + ++ +     +L +  A+L   G YTC  S   G ++    +EV    
Sbjct: 1006 RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPP 1065

Query: 508  EFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 546
            +   P +P  PT  +++    +  E     +   T++W+
Sbjct: 1066 QIAGPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 1102



 Score =  129 bits (323), Expect = 3e-29
 Identities = 153/587 (26%), Positives = 230/587 (39%), Gaps = 73/587 (12%)

Query: 43  GEPATLNCKAEGRPTPTIEWYK-------GGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
           G    L C   G PTP +EW K       GG  ++  +D                LRI  
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-------------VLRITG 278

Query: 96  GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155
                 DEG Y CVA +  G+  + +  L V      +  N +  +  + +  V      
Sbjct: 279 SHVG--DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335

Query: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESEV 214
           RG P P I+W KDG+ L    + +  RGG+ L +   + SDAG Y C  +N VG  E + 
Sbjct: 336 RGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE-KA 394

Query: 215 AELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---GELPKSRY 268
             L V   P+      RP  +          +C ARG P PT+ W  +     E  +SR 
Sbjct: 395 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL 454

Query: 269 EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVAL 328
           E  D   L++        G Y+CVA +  G+A    ++ VQV   P   V +   QV  +
Sbjct: 455 E-TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV--PPQLLVAEGLGQVTTI 511

Query: 329 -GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSD 386
            G+ +   C+A+G+P P I W + G        +P +  +   V+  G  L I +V+   
Sbjct: 512 VGQPLELPCQASGSPVPTIQWLQNG--------RPAEELAGVQVASQGTTLHIDHVELDH 563

Query: 387 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ---TVAVDGTFVLSC--- 440
            G + CQ  N AG+    A  EV   +     P + + P+ Q         +F  +C   
Sbjct: 564 SGLFACQATNEAGT----AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPP 619

Query: 441 VATG---SPVPTIL--WRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
           V  G    P P ++  W   G L        +       LQI    L D G YTC A+  
Sbjct: 620 VHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNL 679

Query: 495 SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP----------SKPEVTDVSRNTVTLS 544
           +GE+     ++V     P   P P +  ++ +A             P+V+    +    S
Sbjct: 680 AGESKREVALKV--LVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSS 737

Query: 545 WQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPN 591
           W   +          IE    +   S++ VA NV   T    GL+ N
Sbjct: 738 WM-GVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 783



 Score =  121 bits (304), Expect = 5e-27
 Identities = 139/501 (27%), Positives = 198/501 (39%), Gaps = 73/501 (14%)

Query: 50  CKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCV 109
           C   G P P + W KG     ++    +    +L  GSLF   +     S  D G Y C 
Sbjct: 24  CGTHGTPKPQVTWRKG---PSSEPLHGQPGVAVLEEGSLFLASV-----SPADSGDYECQ 75

Query: 110 ARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK 166
           A N +G + S  A L V +   +R+D R+  ++V    G+   +EC    G P P I W 
Sbjct: 76  ATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECD-ANGFPVPEIVWL 131

Query: 167 KD----GSPL------------DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGER 210
           KD    G PL                 R+   G  L     +   +G+           +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191

Query: 211 ESEVAELTVLER---PSFVKRPSNLAVTVDDSA-----------EFKCEARGDPVPTVRW 256
               A L   E+   P     P+  +V    +A           E +C   G P P V W
Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251

Query: 257 RKD-DGELPKSRY-EIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV--- 310
            KD    LP   + ++++D   L+I     GD G Y CVA +  G+      L V     
Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311

Query: 311 --GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 368
             GS     V    D +V L       CEA G P P I W ++G+  LL     P S+  
Sbjct: 312 IWGSNETGEVAVMEDHLVQL------LCEARGVPTPNITWFKDGA--LL-----PTSTKV 358

Query: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
                   L +   Q SD G Y C+  N  G+      L+V       PP +   G    
Sbjct: 359 VYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-----VPPTIEGAGGRPY 413

Query: 429 TV-AVDGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 486
            V AV G  V L CVA G P PT+ W  +G+ V+  +    + +  VL++       +G 
Sbjct: 414 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGL 473

Query: 487 YTCIASTPSGEATWSAYIEVQ 507
           Y+C+AS+P+GEA     +EVQ
Sbjct: 474 YSCVASSPAGEAVLQYSVEVQ 494



 Score =  100 bits (248), Expect = 1e-20
 Identities = 115/429 (26%), Positives = 162/429 (37%), Gaps = 57/429 (13%)

Query: 157 GHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
           G P+P ++W+K  S  PL  +     +  G L +     +D+G Y C  TN VG   S  
Sbjct: 28  GTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST-SRR 86

Query: 215 AELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD------------ 260
           A+L V   PS  +  R +N++     S   +C+A G PVP + W KD             
Sbjct: 87  AKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 146

Query: 261 ------GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV-GKAEASATLTVQVGSE 313
                 G++   R  + +  +L   ++  G  G     A      KA   A L       
Sbjct: 147 GWDLGWGQVGGHRL-LDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFP 205

Query: 314 PPHFVVKP----------RDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362
            PH    P            +V+ L G  V  QC  +G P P + W ++    L      
Sbjct: 206 TPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL------ 259

Query: 363 PQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI 421
                   V + G  L IT     D G Y C   + AG       L V        PP I
Sbjct: 260 -PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV------HAPPTI 312

Query: 422 RQGPVNQTVAV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYA 479
                   VAV  D    L C A G P P I W KDG L+ T    +       LQ+  A
Sbjct: 313 WGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRA 372

Query: 480 KLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD-VSR 538
           +  D G YTC AS   G A  +  ++V  +  P        P ++ +   +P   + V+R
Sbjct: 373 QSSDAGVYTCKASNAVGAAEKATRLDV--YVPPTIEGAGGRPYVVKAVAGRPVALECVAR 430

Query: 539 N--TVTLSW 545
              + TLSW
Sbjct: 431 GHPSPTLSW 439



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 81/298 (27%), Positives = 121/298 (40%), Gaps = 33/298 (11%)

Query: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP---KSRYEIRDDHTLKIRKVT 282
           +K   ++A+TV   A   C   G P P V WRK     P   +    + ++ +L +  V+
Sbjct: 7   IKGLGDVALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVS 65

Query: 283 AGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVA--LGRTVTFQCEATG 340
             D G Y C A N VG     A L V V   PP      R   V+   G+++T +C+A G
Sbjct: 66  PADSGDYECQATNEVGSTSRRAKLVVYV---PPSIREDGRKANVSGMAGQSLTLECDANG 122

Query: 341 NPQPAIFWRRE--------GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYIC 392
            P P I W ++        G     +     Q      + +   L    +Q    G    
Sbjct: 123 FPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGA 182

Query: 393 QTLNVAGSIITKA-----------YLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSC 440
           Q     GS  TKA           +          PP V+  G   + + + G  V L C
Sbjct: 183 Q---AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQC 239

Query: 441 VATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGE 497
             +G P P + W KD   V      ++  E+G VL+I  + +GD GRY C+A +P+G+
Sbjct: 240 WTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 297


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  204 bits (520), Expect = 4e-52
 Identities = 149/484 (30%), Positives = 217/484 (44%), Gaps = 40/484 (8%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
            P +   PS +     E   L C+A G P PTI W K G  V T          +LP G L
Sbjct: 3948 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 4002

Query: 89   FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
               RI H   S  D G Y+C+A+N  G A+       V  +         D+    G  A
Sbjct: 4003 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 4055

Query: 149  VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 207
             + C+  RG PEP I+W KDG P+   + + TI+  G+L++      DAG Y C   N V
Sbjct: 4056 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114

Query: 208  GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
            G     V  LT+L  P F   P + ++ + D    +C ARG P P + W  +D  + +  
Sbjct: 4115 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 4173

Query: 268  YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ----VGSEPPHFVVKPRD 323
             E     TL+   V+  D G+Y C AEN VG+ +A + + V+    +  E   ++V+P  
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEP-- 4231

Query: 324  QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383
                +G ++   C   G+P P I W ++G         P + S      Q G LTI   +
Sbjct: 4232 ----VGGSIQLDCVVRGDPVPDIHWIKDG--------LPLRGSHLRHQLQNGSLTIHRTE 4279

Query: 384  RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 443
            R D G Y C   N  G  + K  +    ++  +  PV +  P + TV       L C AT
Sbjct: 4280 RDDAGRYQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQAT 4333

Query: 444  GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 503
            G P PTI W + G  +     R++ L +G L +   + GD G Y C+A    G AT  A+
Sbjct: 4334 GEPTPTIEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAF 4392

Query: 504  IEVQ 507
            + V+
Sbjct: 4393 LVVR 4396



 Score =  188 bits (478), Expect = 3e-47
 Identities = 161/515 (31%), Positives = 223/515 (43%), Gaps = 56/515 (10%)

Query: 28   PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            PP I    +    L+   GE  T+ C   G P   + W K G  +      P S R LL 
Sbjct: 3310 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 3362

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 141
             GS   LRI   +    D G++ CVA +  G A   N +L+V +   L     QN  DV+
Sbjct: 3363 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 3417

Query: 142  VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
            V  G    + C+  RG P P +SW KDG PL  +      +G  L +      D+G Y C
Sbjct: 3418 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 3473

Query: 202  VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
            V  +  GE      +LTV+E P      +P+ L++T     E  C+A+G P P + W KD
Sbjct: 3474 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 3532

Query: 260  DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ-----VGSEP 314
               L +     R    L++R     D G YTC+AE+  G  E S  + VQ     VG   
Sbjct: 3533 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRG 3587

Query: 315  PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
            P FVV      +A G+ V  +C     P P I W R+G      ++       RF     
Sbjct: 3588 PRFVVG-----LAPGQLV-LECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF----- 3636

Query: 375  GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
              L +  +  +D G Y C   N AGS      +E+  V      P IR GP    V+V+ 
Sbjct: 3637 --LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQ 3688

Query: 435  TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
            T +L C A G P P + WRKD V +  +  R + L  G L+I+     D G Y C+AS  
Sbjct: 3689 TALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNS 3748

Query: 495  SGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 529
            +G       + V E   P   P P++  L    P+
Sbjct: 3749 AGSDRQGRDLRVLE--PPAIAPSPSNLTLTAHTPA 3781



 Score =  181 bits (458), Expect = 7e-45
 Identities = 156/545 (28%), Positives = 231/545 (42%), Gaps = 59/545 (10%)

Query: 28   PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I +   P++L ++ G P  L C A+G P P I W+K G+ +   +++ R+ R+L   
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 3552

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
                            D G+Y C+A +  G       S  V +        P      VG
Sbjct: 3553 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 3593

Query: 146  ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 201
                  V+EC      P P I+W +DG  L +D   +   RG  L +     +D+G Y C
Sbjct: 3594 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 3652

Query: 202  VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
               N  G   S    + +   P+    P  + V+V+ +A   C+A G P P V WRKD  
Sbjct: 3653 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 3711

Query: 262  EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
             L P+S R+EI  + +L+I+ V A D G Y C+A N  G       L V    EPP    
Sbjct: 3712 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL---EPPAIAP 3768

Query: 320  KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
             P +  +         CEA+G+P+P + W ++G Q L F  Q       + +  +  L +
Sbjct: 3769 SPSNLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLL 3823

Query: 380  TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
            T     D   + C   N  G    + Y     V     PP I     + TV +    VL+
Sbjct: 3824 TAPGPQDSAQFECVVSNEVGEA-HRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLT 3877

Query: 440  CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
            C +TG P PT+ W K G  +  + S  +   +G L+I  A     GRYTC A   +G A 
Sbjct: 3878 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 3937

Query: 500  WSAYIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 552
               ++ VQ    PV  P P+       +  L+P      E + + R T+T  WQ    + 
Sbjct: 3938 KHVFLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNV 3988

Query: 553  ATPTS 557
            AT  S
Sbjct: 3989 ATGVS 3993



 Score =  179 bits (455), Expect = 1e-44
 Identities = 145/480 (30%), Positives = 202/480 (42%), Gaps = 35/480 (7%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I   P +  V +    TL C A G P P + W+KG + V        S   +  S  
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 1937

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
               LRI   + S  D G Y CVA N  G +      L V +             V V  P
Sbjct: 1938 GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 1994

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 204
              + C    G P PT+ W KDG+P+        ++   G  L +   R SD+G+Y CV  
Sbjct: 1995 VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 2053

Query: 205  NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 263
            + VGE   +V  L V   PS +    N++V  ++S   +C++   P P + W KD   L 
Sbjct: 2054 SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 2112

Query: 264  PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPR 322
            P+    +  D  L ++ +    D G YTC A N  G +E    L V V    P  + +  
Sbjct: 2113 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP--LRESH 2170

Query: 323  DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITN 381
               V  G   +  CE  G P P I WR++G         P + +    VS  G L  +  
Sbjct: 2171 TLTVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQ 2224

Query: 382  VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVL 438
             Q +  G Y C+  NV G+      LEV        PP I   R+ P   +V  DG   L
Sbjct: 2225 AQLAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATL 2278

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
             C ATG P PT+ W +DG  V  +     Q +   L +  A+   TGRY+C+A   +G A
Sbjct: 2279 ECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338



 Score =  175 bits (444), Expect = 3e-43
 Identities = 156/511 (30%), Positives = 221/511 (43%), Gaps = 53/511 (10%)

Query: 35   PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
            P D ++V  G+ A L+C+ +  P PT+ WYK G+ +             L  G    L I
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQR--LEI 3090

Query: 94   VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
               + S  D+G+Y C   N  GEAV    +L V +           V    G P V+ C 
Sbjct: 3091 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 3147

Query: 154  PPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
               G P PT++W KD  P++      +  RGG+L ++  + + AG Y CV  N   E   
Sbjct: 3148 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 3206

Query: 213  EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 263
            +   + VL  P    R S +A    V         CEA G P P V W KD   L     
Sbjct: 3207 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 3263

Query: 264  PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323
            P  R+ + D  +L ++ + A D G+YTCVA N  G+     T+ V V             
Sbjct: 3264 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGT 3322

Query: 324  QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNV 382
             V   G  VT  C   G+P   + W ++G         P   S R  +  +G  L I+ V
Sbjct: 3323 LVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISKV 3374

Query: 383  QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV-L 438
            Q +D G + C   + AG       L+V      + PPV+   PV   N  V V G+ V L
Sbjct: 3375 QLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVEL 3426

Query: 439  SCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGE 497
             C A G P+P + W KDG  + +Q      LE G  LQ+     GD+G Y+C+A + +GE
Sbjct: 3427 PCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGE 3481

Query: 498  ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 528
            A     + V E        +PT+ +L P AP
Sbjct: 3482 ARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 3512



 Score =  175 bits (443), Expect = 4e-43
 Identities = 143/518 (27%), Positives = 216/518 (41%), Gaps = 44/518 (8%)

Query: 1    MIAEPAHFYLFGLICLCS---GSRLRQEDF----PPRIVEHPSDLIVSKGEPATLNCKAE 53
            ++A+ A  YL    CL S   GS  +  D     PP I   PS+L ++   PA L C+A 
Sbjct: 3733 VLAQDAGHYL----CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 3788

Query: 54   GRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNY 113
            G P P + W+K G++++      +    LLPS +L             D   + CV  N 
Sbjct: 3789 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTA-----PGPQDSAQFECVVSNE 3841

Query: 114  LGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD 173
            +GEA  H        +      + +D  V +  P V+ C    G P PT+SW K G+ L 
Sbjct: 3842 VGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST-GIPAPTVSWSKAGAQLG 3898

Query: 174  DKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNL 232
             +     +   G L I       AG+Y C   N  G     V  LTV   P     PS +
Sbjct: 3899 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF-LTVQASPVVKPLPSVV 3957

Query: 233  AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTC 291
                ++     CEA G P PT+ W+K+   +      ++     L+I   +  D G+Y C
Sbjct: 3958 RAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 4017

Query: 292  VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
            +A+N  G A     L VQV   PP       D     G      C+A G+P+P I W ++
Sbjct: 4018 IAKNSAGSAMGKTRLVVQV---PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKD 4074

Query: 352  GSQNLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVT 410
            G        QP   +  +F++  +G+L + N++  D G Y C   N  G    + +L + 
Sbjct: 4075 G--------QPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTIL 4126

Query: 411  DVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 470
             +      PV    P ++++ +     L C A GSP P I W  +   V+   S  +Q  
Sbjct: 4127 VL------PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS--EQDG 4178

Query: 471  NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 508
               LQ       D+G Y C A    G     +++ V+E
Sbjct: 4179 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE 4216



 Score =  174 bits (441), Expect = 6e-43
 Identities = 147/492 (29%), Positives = 213/492 (43%), Gaps = 47/492 (9%)

Query: 24   QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
            Q   PP I+    ++ V   E   L C++   P P + W+K G  +E     PR    L 
Sbjct: 2066 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 2120

Query: 84   PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
               +L  +     R    D G Y C A N  G +  H  +L V +      +    + V 
Sbjct: 2121 ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKH-YNLNVWVAPVFPLRESHTLTVR 2175

Query: 144  VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 200
             G P  + C+  RG P P ISW+KDG PL  +    + ++  G  L +   + +  G Y 
Sbjct: 2176 EGHPTSLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 2234

Query: 201  CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
            C  +N+VG   S+  +L V   P      + P+ ++V  D  A  +C A G P PTV W 
Sbjct: 2235 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 2293

Query: 258  KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
            + DG+   +   ++      +L + +  A   G Y+CVAEN+ G+AE    L+V V   P
Sbjct: 2294 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLV---P 2349

Query: 315  PHFV--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 371
            P  +  + P   +  AL   +T  CEA G P PAI W         F  + P S    + 
Sbjct: 2350 PELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTY 2400

Query: 372  SQTGD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
               G   L +T  Q  D G Y C   N AG       +EV        PP I    + + 
Sbjct: 2401 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEV 2454

Query: 430  VAV-DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
            + V DG T  L C  TG P P + W KDG  ++  D+     +  +LQ+  A L   G Y
Sbjct: 2455 IKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHY 2514

Query: 488  TCIASTPSGEAT 499
            +CIA+   GE T
Sbjct: 2515 SCIAANAVGEKT 2526



 Score =  170 bits (430), Expect = 1e-41
 Identities = 151/556 (27%), Positives = 231/556 (41%), Gaps = 68/556 (12%)

Query: 28   PPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            PP+I    E P+ + V +   ATL C A G+P PT+ W + G+ V  +         L  
Sbjct: 2255 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 2309

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD----V 140
             G    +     R      G Y CVA N  G A       E+++L         D    +
Sbjct: 2310 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSVLVPPELIGDLDPLTNI 2362

Query: 141  MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG-KLMITYTRKSDAGKY 199
              A+  P  + C+   G P P I W +   P+   ++   + GG  L +T T++ D+G Y
Sbjct: 2363 TAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLY 2421

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAEFKCEARGDPVPTVRWR 257
             C+ +N  GE     + + VL  PS         + V D  +A   C   G P P + W 
Sbjct: 2422 SCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF 2480

Query: 258  KDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
            KD   L +  + +   D   L++ +      G Y+C+A N VG+      L+V +     
Sbjct: 2481 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 2540

Query: 316  HFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                   D+   V +   ++  CEA   P P I W ++G+        P ++S    +  
Sbjct: 2541 GGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLP 2592

Query: 374  -TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--- 429
             T  L I N Q+ D G Y C   N  G  +   ++EV       PP + +  P+ +    
Sbjct: 2593 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGEVGVK 2647

Query: 430  ---VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTG 485
                 V+ T  L C +   P PTI W KDG  V T  SR++ L  G +LQI+  ++ D+G
Sbjct: 2648 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQIQPTQVSDSG 2706

Query: 486  RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
            RY C+A+  +GE       + Q+F V +Q P           P   +V D S     LS 
Sbjct: 2707 RYLCVATNVAGE-------DDQDFNVLIQVP-----------PMFQKVGDFSAAFEILSR 2748

Query: 546  QPNLNSGATPTSYIIE 561
            +     G T    I+E
Sbjct: 2749 EEEARGGVTEYREIVE 2764



 Score =  169 bits (429), Expect = 2e-41
 Identities = 145/540 (26%), Positives = 212/540 (39%), Gaps = 92/540 (17%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP +    + ++V+ GE A L C+A G P P + WY+GG  +    +   S ++ +P+  
Sbjct: 697  PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQ 756

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDVMVAVGE 146
                          D G Y C A N LG+A   +A +++A+       + P DV V +G 
Sbjct: 757  ------------ERDAGTYTCRAVNELGDA---SAEIQLAVGHAPQLTELPRDVTVELGR 801

Query: 147  PAVMECQPPRGHPEPTISWKK-DGSPLDDK------DERITIRGGKLMITYTRKSDAGKY 199
             A++ C+   G P PT++W++ DG PL  +              G L        D   Y
Sbjct: 802  SALLACRAT-GRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPY 860

Query: 200  VCVGTNMVGERESEVAELTVLER--PSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRW 256
            VC   N+ G+ ++E A L V     P        + V         C    G P+P   W
Sbjct: 861  VCEARNVFGKVQAE-ARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHW 919

Query: 257  RKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
             KD   LP  SR+ IR D +L + +      G Y+CVA N  G       L VQV   PP
Sbjct: 920  LKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV---PP 976

Query: 316  HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
                     +   G   +  C A+G P P I W +E   N L S  P      ++VS+ G
Sbjct: 977  RIHPTATHHITNEGVPASLPCVASGVPAPTITWTKE--TNALTSRGP-----HYNVSKEG 1029

Query: 376  DLTITNVQRSDVGYYICQTLNVAG----------------------------SIITKAYL 407
             L I      D G Y+C   N  G                              +  A +
Sbjct: 1030 TLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQV 1089

Query: 408  EVTD-------------------VIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 448
            +V D                   V+  + PP ++ GP    V V     L+CVA G+P P
Sbjct: 1090 QVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEP 1149

Query: 449  TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 508
             + W KDGV++  +  +      G +     +  D GRY C AS  +G   W   + V E
Sbjct: 1150 QLSWSKDGVVLQGRGPQ------GSVHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLE 1203



 Score =  166 bits (420), Expect = 2e-40
 Identities = 143/498 (28%), Positives = 205/498 (41%), Gaps = 52/498 (10%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
            P++  H S    S+G    ++C A G PTP I W +  + ++   +D R H  +   G+L
Sbjct: 608  PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ---EDSRIH--VDAQGTL 662

Query: 89   FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD------VMV 142
                I+ G  +  D G Y C A N +G         E   L   +   PS       V+V
Sbjct: 663  ----IIQG-VAPEDAGNYSCQATNEVG------TDQETVTLY--YTDPPSVSAVNAVVLV 709

Query: 143  AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
            AVGE AV+ C+   G P P + W + G  +    E  +   GKL I   ++ DAG Y C 
Sbjct: 710  AVGEEAVLVCEAS-GVPPPRVIWYRGGLEMILAPEGSS--SGKLRIPAAQERDAGTYTCR 766

Query: 203  GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
              N +G+  +E+ +L V   P   + P ++ V +  SA   C A G P PTV WR+ DG+
Sbjct: 767  AVNELGDASAEI-QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 825

Query: 263  L--------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
                       SR    D   L    V   D   Y C A N+ GK +A A L V  G  P
Sbjct: 826  PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV-TGHAP 884

Query: 315  PHFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
            P          V  G+ V+  C    G P P   W ++G        +P    SR S+  
Sbjct: 885  PQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG--------RPLPPGSRHSIRA 936

Query: 374  TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
             G L +    +   G Y C   N AGS      +E+   +  R  P       N+ V   
Sbjct: 937  DGSLHLDRALQEHAGRYSCVATNTAGS--QHRDVELVVQVPPRIHPTATHHITNEGVPAS 994

Query: 434  GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
                L CVA+G P PTI W K+   ++++       + G L I      D G Y C A+ 
Sbjct: 995  ----LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050

Query: 494  PSGEATWSAYIEVQEFGV 511
              G ++    + V    +
Sbjct: 1051 TVGFSSQEMRLSVNRLAL 1068



 Score =  166 bits (420), Expect = 2e-40
 Identities = 126/388 (32%), Positives = 175/388 (45%), Gaps = 35/388 (9%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP I     DL  ++G  A L CKA G P P I W K G+ V            + PSG 
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPV----SGAEGKFTIQPSGE 4092

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
            L  ++ + G+    D G Y C A N +G A      L + +L   F   P D  + +G+ 
Sbjct: 4093 L-LVKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 4145

Query: 148  AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
              + C   RG P P I W  +  P+ +        G  L      + D+G YVC   N V
Sbjct: 4146 LWLRC-AARGSPTPRIGWTVNDRPVTEGVSE-QDGGSTLQRAAVSREDSGTYVCWAENRV 4203

Query: 208  GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
            G  ++     V E  VL+  +F    S L   V  S +  C  RGDPVP + W KD   L
Sbjct: 4204 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 4259

Query: 264  PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
              S  R+++++  +L I +    D G Y C+AEN +G A+    L +Q     P F V+P
Sbjct: 4260 RGSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQ---SAPVFQVEP 4315

Query: 322  RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
            +D  V  G  V  +C+ATG P P I W + G        QP ++S R      G L + N
Sbjct: 4316 QDMTVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLEN 4367

Query: 382  VQRSDVGYYICQTLNVAGSIITKAYLEV 409
            V+  D G Y C   N+ GS   +A+L V
Sbjct: 4368 VETGDAGTYDCVAHNLLGSATARAFLVV 4395



 Score =  160 bits (406), Expect = 7e-39
 Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 66/519 (12%)

Query: 28   PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I     + ++    G+ A L C   G P P + W+K G  +        +H  + P 
Sbjct: 2443 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 2497

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 142
            G L  L+++    S    G Y C+A N +GE   H   +  L   IL         +V V
Sbjct: 2498 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 2553

Query: 143  AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 201
             V  P  + C+     P P I+W KDG+P +       + G   L I   +K DAG+Y C
Sbjct: 2554 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 2612

Query: 202  VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 254
            V TN +GE       + VL  PS  K           +   V+ +   +CE+   P PT+
Sbjct: 2613 VVTNELGEAVKNY-HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 2671

Query: 255  RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-- 310
            RW KD   + P SR ++  +   L+I+     D G Y CVA N+ G+ +    + +QV  
Sbjct: 2672 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 2731

Query: 311  -----GSEPPHFVVKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 355
                 G     F +  R++    G T              C+    P P + W RE    
Sbjct: 2732 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 2788

Query: 356  LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 414
                 QP  +    SV Q G  L I  V+  + G Y C+  N  G       L V     
Sbjct: 2789 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 2840

Query: 415  DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 469
               PPVI  G   +     TV    T  L C A G+PVPTI W ++G L  +   R++ L
Sbjct: 2841 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 2895

Query: 470  ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
            E+G VLQ+  A++ D   Y C+A   +G A     + VQ
Sbjct: 2896 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 2934



 Score =  159 bits (401), Expect = 3e-38
 Identities = 146/510 (28%), Positives = 207/510 (40%), Gaps = 55/510 (10%)

Query: 28   PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV-----------ETDKD 74
            PP I E      VS   G+  TL C A G P P I W K  + V           +    
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 1357

Query: 75   DPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR 134
                HR+L    SL F RI  G     D G+Y C A N  G A      L +        
Sbjct: 1358 QVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 1412

Query: 135  QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR--GGKLMITYTR 192
                +V+   G    ++C    G P P + W KD  P+      + ++  G  L IT + 
Sbjct: 1413 GAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSH 1471

Query: 193  KSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDP 250
              D G+Y CV  +  G++  +  +L V   P+         +AV  D   +  CEARG P
Sbjct: 1472 VGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 1530

Query: 251  VPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
             P + W KD   LP S   +  R    L++ +  + D G YTC A N VG AE +  L V
Sbjct: 1531 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590

Query: 309  QV-----GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
             V     G+    +VVK        GR V  +C A G+P P + W  EG         P 
Sbjct: 1591 YVPPTIEGAGGRPYVVK-----AVAGRPVALECVARGHPSPTLSWHHEGL--------PV 1637

Query: 364  QSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP--V 420
              S+   +   G  L + +   +  G Y C   + AG  + +  +EV      + PP  +
Sbjct: 1638 AESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV------QVPPQLL 1691

Query: 421  IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
            + +G    T  V     L C A+GSPVPTI W ++G             +   L I + +
Sbjct: 1692 VAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVE 1751

Query: 481  LGDTGRYTCIASTPSGEATWSAYIEVQEFG 510
            L  +G + C A+  +G A   A +EV   G
Sbjct: 1752 LDHSGLFACQATNEAGTA--GAEVEVSVHG 1779



 Score =  159 bits (401), Expect = 3e-38
 Identities = 130/475 (27%), Positives = 193/475 (40%), Gaps = 48/475 (10%)

Query: 40   VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 96
            + +  PA L C     P P + WY+        +D P S      +L  G +  + +V  
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 2813

Query: 97   RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 154
              +    G Y C A N +GE   H   L +   ++  D  +   +V V       ++C P
Sbjct: 2814 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 2868

Query: 155  PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 213
              G+P PTISW ++G P         +  G+ L ++    +DA  Y+CV  N  G  E +
Sbjct: 2869 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 2927

Query: 214  VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 270
            +  L V   P         +   ++ S    C+    P P V W KD   L      + +
Sbjct: 2928 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 2987

Query: 271  RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQ----VV 326
               HTL++ +    D G YTC A N  G+ +    L+V V   PP F   PR      +V
Sbjct: 2988 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLV---PPAFRQAPRGPQDAVLV 3044

Query: 327  ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRS 385
             +G      CE    P+P + W ++G        QP   + R    + G  L I   Q S
Sbjct: 3045 RVGDKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVS 3096

Query: 386  DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVAT 443
            D G Y C+  NVAG  +    L V      + PP   + P  +TV+       VL+C  +
Sbjct: 3097 DKGLYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVS 3149

Query: 444  GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
            G P PT+ W KD + V +          G LQ+   +    G YTC+A     EA
Sbjct: 3150 GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 3204



 Score =  157 bits (398), Expect = 6e-38
 Identities = 149/535 (27%), Positives = 216/535 (40%), Gaps = 42/535 (7%)

Query: 28   PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            PP I       ++ V +     L C+A G PTP I W+K G  +      P S +++   
Sbjct: 1500 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 1553

Query: 86   GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 144
            G     ++  GR    D GVY C A N +G A  +    + V    +     P  V    
Sbjct: 1554 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 1610

Query: 145  GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 203
            G P  +EC   RGHP PT+SW  +G P+ + +E R+   G  L +    ++ +G Y CV 
Sbjct: 1611 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 1669

Query: 204  TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 260
            ++  GE   + + E+ V  +    +    +   V    E  C+A G PVPT++W ++   
Sbjct: 1670 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 1729

Query: 261  GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK 320
             E            TL I  V     G + C A N  G A A   ++V  G   P  +  
Sbjct: 1730 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH-GEWAPGVLEV 1788

Query: 321  PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQT 374
            P  Q    G        A  +P     W       L+  +  P S          + S  
Sbjct: 1789 PIGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 1847

Query: 375  GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 434
              L I  V   D G Y C   N+AG    +  L+V        PP I  GPVN+ V  + 
Sbjct: 1848 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENA 1901

Query: 435  TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 494
            +  L C+A+G P P + W K    VS+       ++  VL+I  A+L D G Y C+AS  
Sbjct: 1902 SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNV 1961

Query: 495  SGEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
            +G            +G+ V  PPR T P   PS P    V    R T   +  P+
Sbjct: 1962 AGSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 2006



 Score =  156 bits (394), Expect = 2e-37
 Identities = 159/551 (28%), Positives = 219/551 (39%), Gaps = 72/551 (13%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
            PP++   P  L V  GE   LNC AEG P P + W K G  ++             P GS
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG----------PQGS 1168

Query: 88   LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDF--RQNPSDVMVAV- 144
            + F  I        D G Y C A N  G        +E+ +L          S ++  V 
Sbjct: 1169 VHFAAI-----RTSDAGRYRCEASNSAGVDA---WEVELRVLEPPHWGADETSGLLERVA 1220

Query: 145  GEPAVMECQPPRGHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
            GE A + C P RG P+P ++W+K  S  PL  +     +  G L +     +D+G Y C 
Sbjct: 1221 GENASLPC-PARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279

Query: 203  GTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
             TN VG   S  A+L V   PS  +  R +N++     S   +C+A G PVP + W KD 
Sbjct: 1280 ATNEVGS-TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA 1338

Query: 261  ------------------GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 302
                              G++   R  + +  +L   ++  GD G Y+C AEN  G A+ 
Sbjct: 1339 QLVGVPLGWAGYGWDLGWGQVGGHRL-LDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR 1397

Query: 303  SATLTVQVGSEPPHFVVKPRDQVV--ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
               L V     PP  +     Q V    G  V  QC  +G P P + W ++    L    
Sbjct: 1398 DFHLLVLT---PPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL---- 1450

Query: 361  QPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
                      V + G  L IT     D G Y C   + AG       L V        PP
Sbjct: 1451 ---PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV------HAPP 1501

Query: 420  VIRQGPVNQTVAV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
             I        VAV  D    L C A G P P I W KDG L+ T    +       LQ+ 
Sbjct: 1502 TIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLG 1561

Query: 478  YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD-V 536
             A+  D G YTC AS   G A  +  ++V  +  P        P ++ +   +P   + V
Sbjct: 1562 RAQSSDAGVYTCKASNAVGAAEKATRLDV--YVPPTIEGAGGRPYVVKAVAGRPVALECV 1619

Query: 537  SRN--TVTLSW 545
            +R   + TLSW
Sbjct: 1620 ARGHPSPTLSW 1630



 Score =  154 bits (388), Expect = 9e-37
 Identities = 159/573 (27%), Positives = 220/573 (38%), Gaps = 55/573 (9%)

Query: 26   DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
            D PP++V  P+ + VS GE A L+C+  G     + W              R  R+L  S
Sbjct: 515  DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 560

Query: 86   ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
                  L  L +        D G Y CVA N  G      AS+ + +        + S  
Sbjct: 561  TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 617

Query: 141  MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
              + G    + C    G+P P ISW ++   L + D RI +   G L+I      DAG Y
Sbjct: 618  HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 675

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
             C  TN VG  + E   L   + PS     + + V V + A   CEA G P P V W + 
Sbjct: 676  SCQATNEVGT-DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 734

Query: 260  DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVV 319
              E+  +  E      L+I      D G+YTC A N +G A A   L V      P    
Sbjct: 735  GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV---GHAPQLTE 790

Query: 320  KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 379
             PRD  V LGR+    C ATG P P + WRR   Q L       +  SR     +G L  
Sbjct: 791  LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFF 849

Query: 380  TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 439
             +V   D   Y+C+  NV G +  +A L VT      PP +    P  + +      +  
Sbjct: 850  ESVAPEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVRVLEGQPVSLPC 906

Query: 440  CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 499
             V  G P+P   W KDG  +    SR     +G L +  A     GRY+C+A+  +G   
Sbjct: 907  IVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH 965

Query: 500  WSAYIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
                + VQ       PPR              P     + S    P +T         S 
Sbjct: 966  RDVELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 1019

Query: 546  QPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 578
             P+ N     T  I +  +  +G+   T    V
Sbjct: 1020 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052



 Score =  152 bits (385), Expect = 2e-36
 Identities = 143/537 (26%), Positives = 197/537 (36%), Gaps = 86/537 (16%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLP-SG 86
            P++ E P D+ V  G  A L C+A GRP PT+ W +G G+ +       R  R   P SG
Sbjct: 786  PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 845

Query: 87   SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
             LFF  +     +  D+  YVC ARN  G+  +    +           +   V V  G+
Sbjct: 846  VLFFESV-----APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 900

Query: 147  PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
            P  + C    G P P   W KDG PL           G L +    +  AG+Y CV TN 
Sbjct: 901  PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 960

Query: 207  VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-------------- 252
             G +  +V EL V   P      ++        A   C A G P P              
Sbjct: 961  AGSQHRDV-ELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 1019

Query: 253  -------------------------------TVRWRKDDGELPKSR----------YEIR 271
                                           TV +   +  L  +R          Y + 
Sbjct: 1020 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLL 1079

Query: 272  DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRT 331
               +L++ +V  GD G Y C A N  G A     L VQV   PP     PR   V +G  
Sbjct: 1080 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQV---PPQVQPGPRVLKVLVGEA 1136

Query: 332  VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 391
            +   C A GNP+P + W ++G   ++   + PQ S  F+  +T          SD G Y 
Sbjct: 1137 LDLNCVAEGNPEPQLSWSKDG---VVLQGRGPQGSVHFAAIRT----------SDAGRYR 1183

Query: 392  CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTI 450
            C+  N AG    +  L V +     PP             V G    L C A G+P P +
Sbjct: 1184 CEASNSAGVDAWEVELRVLE-----PPHWGADETSGLLERVAGENASLPCPARGTPKPQV 1238

Query: 451  LWRKDGVLVSTQ-DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
             WRK            +  LE G L +      D+G Y C A+   G  +  A + V
Sbjct: 1239 TWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295



 Score =  150 bits (379), Expect = 1e-35
 Identities = 149/522 (28%), Positives = 213/522 (40%), Gaps = 74/522 (14%)

Query: 32   VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
            V+ P  L+V++G         +P  L C+A G P PTI+W + G   E       +   +
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQV 1738

Query: 83   LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
               G+   +  V    S    G++ C A N  G A    A +EV++  +     P  + V
Sbjct: 1739 ASQGTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 1788

Query: 143  AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 184
             +G+           PA   C PP  RG   HP+P +   W   GS L  +   I +   
Sbjct: 1789 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 1845

Query: 185  ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
                L I      D G Y C  TN+ GE + EVA L VL  P+    P N AV  + S  
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 1904

Query: 242  FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
             +C A G P P V W K  G  P S +       D   L+I +    D GSY CVA N+ 
Sbjct: 1905 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 1962

Query: 298  GKAEASATLTVQVGSEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL 356
            G  E    L V V   PP   + P     V +   V   C ATG P P + W ++G+   
Sbjct: 1963 GSTELRYGLRVNV---PPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP-- 2017

Query: 357  LFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD 415
                  P  +    V   G  LT+ + + SD G Y C  ++  G       L+V      
Sbjct: 2018 ----VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------ 2067

Query: 416  RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ 475
              PP I    +N +V  + +  L C +   P P + W KDG  +  +       +  +LQ
Sbjct: 2068 HMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ 2127

Query: 476  IRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 517
            +  A + D G YTC A   +G +    +  +  +  PV P R
Sbjct: 2128 VDRADVWDAGHYTCEALNQAGHS--EKHYNLNVWVAPVFPLR 2167



 Score =  149 bits (375), Expect = 3e-35
 Identities = 148/496 (29%), Positives = 207/496 (41%), Gaps = 62/496 (12%)

Query: 43   GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
            GE A+L C A G P P + W KG     ++    +    +L  GSLF   +     S  D
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPS---SEPLHGQPGVAVLEEGSLFLASV-----SPAD 1272

Query: 103  EGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
             G Y C A N +G + S  A L V +   +R+D R+  ++V    G+   +EC    G P
Sbjct: 1273 SGDYECQATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFP 1328

Query: 160  EPTISWKKD----GSPL------------DDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
             P I W KD    G PL                 R+   G  L     ++ D+G Y C  
Sbjct: 1329 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA 1388

Query: 204  TNMVGERESEVAELTVLERPSFVKRPSNLAVT--VDDSAEFKCEARGDPVPTVRWRKD-D 260
             N  G  + +   L VL  PS +   +   V        E +C   G P P V W KD  
Sbjct: 1389 ENQAGTAQRDF-HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ 1447

Query: 261  GELPKSRY-EIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV-----GSE 313
              LP   + ++++D   L+I     GD G Y CVA +  G+      L V       GS 
Sbjct: 1448 PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSN 1507

Query: 314  PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                V    D +V L       CEA G P P I W ++G+  LL     P S+       
Sbjct: 1508 ETGEVAVMEDHLVQL------LCEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRG 1554

Query: 374  TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AV 432
               L +   Q SD G Y C+  N  G+      L+V       PP +   G     V AV
Sbjct: 1555 GRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV-----PPTIEGAGGRPYVVKAV 1609

Query: 433  DGTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 491
             G  V L CVA G P PT+ W  +G+ V+  +    + +  VL++       +G Y+C+A
Sbjct: 1610 AGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 1669

Query: 492  STPSGEATWSAYIEVQ 507
            S+P+GEA     +EVQ
Sbjct: 1670 SSPAGEAVLQYSVEVQ 1685



 Score =  138 bits (348), Expect = 4e-32
 Identities = 121/459 (26%), Positives = 191/459 (41%), Gaps = 38/459 (8%)

Query: 102  DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
            DEG+Y C A N  GE+     +L+V ++  +    P +  V       +EC    G P P
Sbjct: 1859 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 1915

Query: 162  TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
             +SW K   P+       +++ G  L I   + SDAG Y CV +N+ G  E     L V 
Sbjct: 1916 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 1974

Query: 221  ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 275
              P     PS    V V+      C A G P PT+ W KD   +  +             
Sbjct: 1975 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 2034

Query: 276  LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQ 335
            L +    A D G Y+CVA + VG+      L V +   PP  + +  +  V    +V  +
Sbjct: 2035 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM---PPSILGEELNVSVVANESVALE 2091

Query: 336  CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYIC 392
            C++   P P + W ++G               R  V  + D  +  V R+DV   G+Y C
Sbjct: 2092 CQSHAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTC 2141

Query: 393  QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 452
            + LN AG   ++ +  +   +A   P  +R+     TV       LSC   G P P I W
Sbjct: 2142 EALNQAGH--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTSLSCECRGVPFPKISW 2196

Query: 453  RKDGVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ--- 507
            RKDG  +  + + ++ +     +L +  A+L   G YTC  S   G ++    +EV    
Sbjct: 2197 RKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPP 2256

Query: 508  EFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 546
            +   P +P  PT  +++    +  E     +   T++W+
Sbjct: 2257 QIAGPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 2293



 Score =  132 bits (333), Expect = 2e-30
 Identities = 133/491 (27%), Positives = 187/491 (38%), Gaps = 90/491 (18%)

Query: 28   PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS-HRMLLPSG 86
            PPRI    +  I ++G PA+L C A G P PTI W K     ET+    R  H  +   G
Sbjct: 975  PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK-----ETNALTSRGPHYNVSKEG 1029

Query: 87   SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
            +L        + S  D G YVC A N +G +                     ++ ++V  
Sbjct: 1030 TLLI-----AQPSAQDAGAYVCTATNTVGFS-------------------SQEMRLSVNR 1065

Query: 147  PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
             A+ +             W++ G           +  G L +   +  D+G Y C  +N 
Sbjct: 1066 LALSK-----------YVWEEYG----------LLPSGSLRLAQVQVGDSGHYECTASNP 1104

Query: 207  VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
             G        L V   P     P  L V V ++ +  C A G+P P + W K DG + + 
Sbjct: 1105 AGSASHRYV-LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK-DGVVLQG 1162

Query: 267  RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVV 326
            R      H   IR     D G Y C A N  G       L V    EPPH+       ++
Sbjct: 1163 RGPQGSVHFAAIR---TSDAGRYRCEASNSAGVDAWEVELRV---LEPPHWGADETSGLL 1216

Query: 327  --ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 384
                G   +  C A G P+P + WR+  S       +P       +V + G L + +V  
Sbjct: 1217 ERVAGENASLPCPARGTPKPQVTWRKGPSS------EPLHGQPGVAVLEEGSLFLASVSP 1270

Query: 385  SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--PVNQTVAVDGTFVLSCVA 442
            +D G Y CQ  N  GS   +A L V        PP IR+     N +     +  L C A
Sbjct: 1271 ADSGDYECQATNEVGSTSRRAKLVV------YVPPSIREDGRKANVSGMAGQSLTLECDA 1324

Query: 443  TGSPVPTILWRKDGVLVST--------------QDSRIKQLENG-VLQIRYAKLGDTGRY 487
             G PVP I+W KD  LV                Q    + L+ G  L     + GD+G Y
Sbjct: 1325 NGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLY 1384

Query: 488  TCIASTPSGEA 498
            +C A   +G A
Sbjct: 1385 SCRAENQAGTA 1395



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 62/243 (25%), Positives = 102/243 (41%), Gaps = 22/243 (9%)

Query: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
           R+ +  L + R ++   + + +I + +  + G+Y C A +  G   A A + V   ++PP
Sbjct: 461 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVV---TDPP 517

Query: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
             +V   +  V+ G T    C   G     + W R+           P S+ R  V+Q  
Sbjct: 518 PQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLA 568

Query: 376 DLT--ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
           DL+  I+ +  +D G Y C   N  G      +L V      R  P +     +Q  +  
Sbjct: 569 DLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQG 622

Query: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 493
               +SC A+G P P I W ++   +  +DSRI     G L I+     D G Y+C A+ 
Sbjct: 623 VEVKVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATN 681

Query: 494 PSG 496
             G
Sbjct: 682 EVG 684



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 6/140 (4%)

Query: 369 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 428
           F  S      I    +++ G Y C  ++ AG+   KA + VTD     PPP +   P N 
Sbjct: 473 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTD-----PPPQLVPAP-NV 526

Query: 429 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
           TV+   T VLSC   G     + W +D  ++     R+ QL +  L+I      D GRY 
Sbjct: 527 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQ 586

Query: 489 CIASTPSGEATWSAYIEVQE 508
           C+AS  +G    S ++ V+E
Sbjct: 587 CVASNANGVTRASVWLLVRE 606


>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score =  204 bits (518), Expect = 7e-52
 Identities = 228/858 (26%), Positives = 348/858 (40%), Gaps = 107/858 (12%)

Query: 40  VSKGEPATLNC-KAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
           VS GE A +   +    P P + W++ G ++      P S   +    +L  L  V    
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIP-----PSSRIAITLENTLVILSTV---- 174

Query: 99  SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM-------------VAVG 145
             PD G Y   A N   +    N + +   L  +    P+D +             VA  
Sbjct: 175 -APDAGRYYVQAVN---DKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGT 230

Query: 146 EPAVMECQP-PRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 204
               +EC    R   +  I WKKDG  L      I+    +L I     SDAG Y C   
Sbjct: 231 SEVTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAV 287

Query: 205 NMVGERESEV--AELTVLERPSFVKRPS-NLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
                  S V  A L+VLE P FVK P  ++   ++   +  C+A+G P P++ W KD  
Sbjct: 288 LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347

Query: 262 --ELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
             E+ K +R+  R+D  L+I  +   D G + C A N  G+ + S  L V   S  P+  
Sbjct: 348 VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT--SIAPNIT 405

Query: 319 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 378
             P D  V  G +V   CE +G P+PAI W++        S Q P    RF+  ++G L 
Sbjct: 406 RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLP----RFTPLESGSLL 461

Query: 379 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 438
           I+    SD G Y C   N  G  + +A  ++      R    I + P +Q+V       +
Sbjct: 462 ISPTHISDAGTYTCLATNSRG--VDEASADLVVWARTR----ITKPPQDQSVIKGTQASM 515

Query: 439 SCVATGSPVPTI--LWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495
            C  T  P  TI  +W KDG  + T+   RI+   NG L I     GD G YTC   +  
Sbjct: 516 VCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG 575

Query: 496 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVT--DVSRNTVTLSWQPNLNSGA 553
           G  + SA++ V++               +P AP  P  T   V R  + L+W    +  +
Sbjct: 576 GNDSRSAHLRVRQ---------------LPHAPEHPVATLSTVERRAINLTWTKPFDGNS 620

Query: 554 TPTSYIIEAFSHASGSSWQTVAENV--KTETSAIKGLKPNAIYLFLVRAANAYGISDPSQ 611
               YI+E     + + W  +  +V  K  +  +KGL P   Y F + A N  G    S+
Sbjct: 621 PLIRYILE--MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSK 678

Query: 612 ISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYI 668
            ++ V   +  PT+        Q  + +           ++ SI + W       Q+  +
Sbjct: 679 DTERVSLPEEPPTA------PPQNVIASG---------RTNQSIMIQWQPPPESHQNGIL 723

Query: 669 QGYKILYRPSGANHGESDWLVFEVRTPAK-NSVVIPDLRKGVNYEIKARPFFNEFQGADS 727
           +GY I Y  +G   G      F+  T A  N++++ DL    NYEI+   + +   G  S
Sbjct: 724 KGYIIRYCLAGLPVGYQ----FKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS 779

Query: 728 EIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETR 787
                 TL+  P+ PP  V       N T I  +W  P     NG+ Q YK+     E  
Sbjct: 780 SKVTEWTLQGVPTVPPGNVHAEAT--NSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQE 837

Query: 788 YHINKTVDGSTF--SVVIPFLVPGIR----YSVEVAASTGAGSGVKSEPQFIQLDAHGNP 841
             +        F  S+ + F V G++    Y   V   T  G G +S PQ ++   H + 
Sbjct: 838 EEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVR--THEDV 894

Query: 842 VSPEDQVSLAQQISDVVK 859
             P   +S ++ +   +K
Sbjct: 895 PGPVGHLSFSEILDTSLK 912



 Score =  190 bits (482), Expect = 1e-47
 Identities = 220/874 (25%), Positives = 338/874 (38%), Gaps = 101/874 (11%)

Query: 24  QEDFPPRIVEHPSDLIVS-KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
           Q+D  P     P    V  +G    L C AEG      +W      +     +   +R +
Sbjct: 21  QDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLE---YRYM 77

Query: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
           + S              R   G Y C+ RN +G  +     ++VA +   F +      V
Sbjct: 78  ITS------------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYM-GSFEEGEKHQSV 124

Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
           + GE AV+        P+P ++W +DG  +             L+I  T   DAG+Y   
Sbjct: 125 SHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQ 184

Query: 203 GTNMVG--ERESEVAELTVLE--------RPSFVKRPSNLAVTVDDS-AEFKCEARGDPV 251
             N      + S+   LTV           P+ +  P N +V    S    +C A   P+
Sbjct: 185 AVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPL 244

Query: 252 PTVR--WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA---ENMVGKAEASATL 306
             +   W+KD   L     +   +  L I   T  D G Y C A    + V      A L
Sbjct: 245 IKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 302

Query: 307 TVQVGSEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 365
           +V    EPP FV +P   + A + + V   C+A G P P+I W ++       +    + 
Sbjct: 303 SV---LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDA------AVVEVEK 353

Query: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 425
            +RF     G L I+ +   D G + C   N AG + T  YL VT +      P I +GP
Sbjct: 354 LTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI-----APNITRGP 408

Query: 426 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLV---STQDSRIKQLENGVLQIRYAKLG 482
           ++ TV    + VL+C  +G+P P I W+K   ++   S Q  R   LE+G L I    + 
Sbjct: 409 LDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS 468

Query: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVT 542
           D G YTC+A+   G    SA + V       +PP+         A     VT   R T+ 
Sbjct: 469 DAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR 528

Query: 543 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAAN 602
             W+ +  +  T +   I    + S    QT + ++ T T  +     N       R+A+
Sbjct: 529 YIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGND-----SRSAH 583

Query: 603 AYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD 662
                 P     PV T   +   + ++    +   GN+ L  +   +L  S     WTV 
Sbjct: 584 LRVRQLPHAPEHPVATLSTV-ERRAINLTWTKPFDGNSPLIRY---ILEMSENNAPWTV- 638

Query: 663 QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEF 722
                                    L+  V  P   SV +  L    +Y+ +     +  
Sbjct: 639 -------------------------LLASV-DPKATSVTVKGLVPARSYQFRLCAVNDVG 672

Query: 723 QGADSEIKFAKTL-EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-W 780
           +G  S+     +L EE P+APPQ V  S       +I++ WQPPPE  QNG+++ Y + +
Sbjct: 673 KGQFSKDTERVSLPEEPPTAPPQNVIASGR--TNQSIMIQWQPPPESHQNGILKGYIIRY 730

Query: 781 CL-GNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHG 839
           CL G    Y      D    ++++  L+    Y +EVAA   AG GV S  +  +    G
Sbjct: 731 CLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS-KVTEWTLQG 789

Query: 840 NPVSPEDQVSLAQQISDVVK------QPAFIAGI 867
            P  P   V      S  ++       P FI GI
Sbjct: 790 VPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGI 823



 Score =  133 bits (334), Expect = 2e-30
 Identities = 197/838 (23%), Positives = 311/838 (37%), Gaps = 116/838 (13%)

Query: 29  PRIVEHPSDLIVSKG-EPATLNCKAEGRPTPTIE--WYKGGERVETDKDDPRSHRMLLPS 85
           P I+  P +  V  G    TL C A  RP   +   W K G  +     D  + R+ +P+
Sbjct: 215 PTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISD-HNRRLTIPN 273

Query: 86  GSLFFLRIVHGRKSRPDEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
                        +  D G Y C  V R+    +V   A L V +    F + P   + A
Sbjct: 274 ------------PTGSDAGYYECEAVLRSSSVPSVVRGAYLSV-LEPPQFVKEPERHITA 320

Query: 144 VGEPAV-MECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG-GKLMITYTRKSDAGKYV 200
             E  V + CQ  +G P P+I+W KD + ++ +K  R   R  G L I+     D G + 
Sbjct: 321 EMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 379

Query: 201 CVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
           C   N  GE ++          P+  + P +  V    S    CE  G P P + W+K +
Sbjct: 380 CFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGE 439

Query: 261 -----GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
                G +   R+   +  +L I      D G+YTC+A N  G  EASA L V   +   
Sbjct: 440 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTR-- 497

Query: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                P+DQ V  G   +  C  T +P+  I   W ++G+          +S  R  + +
Sbjct: 498 -ITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGAT------LGTESHPRIRLDR 550

Query: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ----- 428
            G L I+     D+G Y C+ ++  G+    A+L V  +      PV     V +     
Sbjct: 551 NGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINL 610

Query: 429 --TVAVDGT-----FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKL 481
             T   DG      ++L      +P   +L   D    S     +    +   Q R   +
Sbjct: 611 TWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARS--YQFRLCAV 668

Query: 482 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTV 541
            D G+      T             +   +P +PP     N+I S  +          ++
Sbjct: 669 NDVGKGQFSKDT-------------ERVSLPEEPPTAPPQNVIASGRTN--------QSI 707

Query: 542 TLSWQPNLNS--GATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAI----YL 595
            + WQP   S        YII          +Q   +N+ T+      L  + I    Y 
Sbjct: 708 MIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF--KNI-TDADVNNLLLEDLIIWTNYE 764

Query: 596 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 655
             V A N+ G+   S        Q V     G  H +                  +S++I
Sbjct: 765 IEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEAT----------------NSTTI 808

Query: 656 EVHWTVDQQSQYI----QGYKILYRPSGANHGESDWLVFEVRTPAKNSV---VIPDLRKG 708
              W      Q+I    QGYK++   +     E +  +   R   ++S+    +  L+K 
Sbjct: 809 RFTWNAPSP-QFINGINQGYKLI---AWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKF 864

Query: 709 VNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPED 768
             Y      F     G  S  +  +T E+ P   P G  +S ++   T++ VSWQ P E 
Sbjct: 865 TEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPG--PVG-HLSFSEILDTSLKVSWQEPGE- 920

Query: 769 TQNGMVQEYKV-WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 825
            +NG++  Y++ W   N T   +   +   T    +  L     Y++EVAA T  G G
Sbjct: 921 -KNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG 977



 Score = 91.3 bits (225), Expect = 7e-18
 Identities = 90/338 (26%), Positives = 141/338 (41%), Gaps = 55/338 (16%)

Query: 525  PSAPSKPEVT--DVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 582
            P  PS+P V   DV   +V LSW+P  + G +P  Y            W   + +V    
Sbjct: 1400 PQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTRELPSGRWALHSASVSHNA 1458

Query: 583  SA--IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 640
            S+  +  LKP   Y F V+A N  G S+ S+ S+ + T    P                 
Sbjct: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA-------------- 1504

Query: 641  VLHLHNPTVLS-----SSSIEVHW---TVDQQSQYIQGYKILYRP-----------SGAN 681
                  PT+LS     ++S+ + W     D+ +  + G++I YR             G N
Sbjct: 1505 ------PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGIN 1558

Query: 682  HGESDWL----VFEVRTPAKNSVV---IPDLRKGVNYEIKARPFFNEFQGADSEIKFAKT 734
            +  + W     ++ +R  ++ S+    + +L K   YEI+   +    +G  S  +    
Sbjct: 1559 NPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFV 1618

Query: 735  LEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYHINK 792
             E  P+A P+ V V  +    T + V+W+PPP D+QNG +Q YK+  W           K
Sbjct: 1619 GEAVPTAAPRNVVV--HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVK 1676

Query: 793  TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 830
            T+  +  SV +  L     Y V VAA   AG G +S P
Sbjct: 1677 TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTP 1714



 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 90/388 (23%), Positives = 150/388 (38%), Gaps = 41/388 (10%)

Query: 469  LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 528
            L N  L+ R   L     YT   +  + +            GVP + P P         P
Sbjct: 946  LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP---------P 996

Query: 529  SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHA--SGSSWQTV---AENVKTETS 583
            +   ++++   +VTL ++P  +   + + +++EA       G  W  +   +      + 
Sbjct: 997  TNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSM 1056

Query: 584  AIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 643
             +  L P   Y F +R  N  G S PSQ S  ++T    P            ++  A + 
Sbjct: 1057 EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPP------------DMAPANVS 1104

Query: 644  LHNPTVLSSSSIEVHWTVDQQSQY-----IQGYKILYRPSGANHGESDWLVFEVRTPAKN 698
            L      S +S+ + W    + +Y       GYKI Y  S   HG++  L   V+   + 
Sbjct: 1105 LR---TASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSD-GHGKT--LSHVVQDRVER 1158

Query: 699  SVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAI 758
               I DL +   Y ++ + F     G  S+    +T E  PS+ P  V+        +++
Sbjct: 1159 DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALAT--TSSSM 1216

Query: 759  LVSWQPPPEDTQNGMVQEYKVWC--LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 816
            LV W   PE  +NG+V  YKV      ++T+         S+ S  +  L   + Y V+V
Sbjct: 1217 LVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQV 1276

Query: 817  AASTGAGSGVKSEPQFIQLDAHGNPVSP 844
             A T  G G  S P  ++      P  P
Sbjct: 1277 LAFTRIGDGSPSHPPILERTLDDVPGPP 1304



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 63/278 (22%), Positives = 117/278 (42%), Gaps = 31/278 (11%)

Query: 510  GVPVQPP---RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHA 566
            G P  PP   R  D   +P  P      +V   +V L WQP         +Y I    + 
Sbjct: 1285 GSPSHPPILERTLDD--VPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNT 1342

Query: 567  SGSSWQTV---AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLP 623
            + ++  TV   A + +  T+   GLKP ++YLF + A    G  + ++    V T +   
Sbjct: 1343 TTANTATVEVLAPSARQYTAT--GLKPESVYLFRITAQTRKGWGEAAEAL--VVTTEKRD 1398

Query: 624  TSQGVDHKQVQRE--LGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 681
              Q      VQ+E     +VL    P     S +  ++T+  Q++ +   +     +  +
Sbjct: 1399 RPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR-YYTI--QTRELPSGRWALHSASVS 1455

Query: 682  HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 741
            H  S ++V  ++                 + +KA     + + ++ E +   TL+ AP  
Sbjct: 1456 HNASSFIVDRLKP-----------FTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDE 1503

Query: 742  PPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 779
             P  ++V+ +    T++L+ WQPP ED  NG++  +++
Sbjct: 1504 APTILSVTPH--TTTSVLIRWQPPAEDKINGILLGFRI 1539



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 73/317 (23%), Positives = 118/317 (37%), Gaps = 39/317 (12%)

Query: 526  SAPSKPEVTDVSRNTVTLSWQPNL--NSGATPTSYIIEAFSHASGSSWQTVAENVKTETS 583
            +AP    V   +   + ++W+P    +       Y I  +    G+  + V      E S
Sbjct: 1625 AAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENS 1684

Query: 584  A-IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTS-QGVDHKQVQRELGNAV 641
              +K L     Y+  V A NA G   P       +TQ   P++   V   +         
Sbjct: 1685 VKLKNLTGYTAYMVSVAAFNAAG-DGPRSTPTQGQTQQAAPSAPSSVKFSE--------- 1734

Query: 642  LHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV 700
                    L+++S+ V W   Q  +  ++GY+++Y P     G S  +  +V+  +   +
Sbjct: 1735 --------LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWL 1786

Query: 701  VIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAP-PQGVTVSKNDGNGTAIL 759
             + DL +GV Y  + R     +     EI+   T      AP P GV +       +AI 
Sbjct: 1787 KVKDLAEGVTYRFRIRAKTFTY---GPEIEANVTTGPGEGAPGPPGVPIIVR--YSSAIA 1841

Query: 760  VSWQPPPEDTQNGMVQEYKVWCLGNETRY------HINKTVDGSTFSVVIPFLVPGIRYS 813
            + W     D   G +  Y +    ++          I K V   TFS+ I  L PG+ Y 
Sbjct: 1842 IHWS--SGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDI--LKPGVSYD 1897

Query: 814  VEVAASTGAGSGVKSEP 830
              V A    G G  S P
Sbjct: 1898 FRVIAVNDYGFGTPSSP 1914



 Score = 40.0 bits (92), Expect = 0.018
 Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 9/121 (7%)

Query: 509  FGVPVQPPRPTDPNLIPSAPSKPEVTDVSR--NTVTLSWQPNLNSGATPTSYIIEAFSHA 566
            +G  ++    T P     AP  P V  + R  + + + W          T Y+IEA    
Sbjct: 1808 YGPEIEANVTTGPG--EGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSD 1865

Query: 567  SGSSWQTVAENVKTETSA----IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 622
             G  W  + +++  E S+    +  LKP   Y F V A N YG   PS  S  V  Q   
Sbjct: 1866 EGL-WDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKAN 1924

Query: 623  P 623
            P
Sbjct: 1925 P 1925



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 56/230 (24%), Positives = 93/230 (40%), Gaps = 38/230 (16%)

Query: 500  WSAY-IEVQEFGVPVQPPRPTDPN-----LIPSAPSKPEVTDVSRNTVTLSWQ-PNLNSG 552
            ++AY + V  F      PR T          PSAPS  + ++++  +V +SW+ P   +G
Sbjct: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752

Query: 553  ATPTSYII-EAFSHASGSSWQTVAENVKTETS---AIKGLKPNAIYLFLVRAAN-AYGIS 607
                  ++ E  S   G S + V  +VK  +     +K L     Y F +RA    YG  
Sbjct: 1753 ILEGYRLVYEPCSPVDGVS-KIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPE 1811

Query: 608  DPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTV-DQQS 665
              + ++      +  P   GV                  P ++  SS+I +HW+  D   
Sbjct: 1812 IEANVT--TGPGEGAPGPPGV------------------PIIVRYSSAIAIHWSSGDPGK 1851

Query: 666  QYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD-LRKGVNYEIK 714
              I  Y I  RPS  + G  D L+ ++     +     D L+ GV+Y+ +
Sbjct: 1852 GPITRYVIEARPS--DEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFR 1899


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score =  202 bits (513), Expect = 3e-51
 Identities = 216/824 (26%), Positives = 329/824 (39%), Gaps = 90/824 (10%)

Query: 40  VSKGEPATLNC-KAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
           VS+G  A LN       P P + W++ G ++      P +   +     L  L       
Sbjct: 202 VSQGRAAILNLLPITSYPRPQVTWFREGHKII-----PSNRIAITLENQLVILAT----- 251

Query: 99  SRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVM-------VAVGEPA 148
           +  D G Y   A N        +  + ++I RD        P+ V+       VA     
Sbjct: 252 TTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSET 311

Query: 149 VMEC-QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT--N 205
            +EC    R   + +++WK++G  +          G +L I+    +D G YVC      
Sbjct: 312 TLECIASARPVEDLSVTWKRNGVRITSGLHSF---GRRLTISNPTSADTGPYVCEAALPG 368

Query: 206 MVGERESEVAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---G 261
              E     A L ++E P F   P S ++  V+++ +  C+A G P+PT++W KD     
Sbjct: 369 SAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISIS 428

Query: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKP 321
            L   RY++     L+I+K+   D G + C A N  G+ +    L V   +  P F  +P
Sbjct: 429 RLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVT--NIAPVFTQRP 486

Query: 322 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 381
            D  V  G T   +CE +G P+PAI W+RE       S + P    RF + ++G L I  
Sbjct: 487 VDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIP----RFMLLESGGLQIAP 542

Query: 382 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 441
           V   D G Y C   N  GS+   A L V +  +      I   P +  V    T  L C 
Sbjct: 543 VFIQDAGNYTCYAANTEGSLNASATLTVWNRTS------IVHPPEDHVVIKGTTATLHCG 596

Query: 442 ATGSPVPTI--LWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 498
           AT  P  ++  +W+KD V L  +  SRI   ++G L I     GD G Y+C   +  G  
Sbjct: 597 ATHDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGND 656

Query: 499 TWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSY 558
           +  A +EV E  +P  P      NL+ S  S         + V LSW    +  +    Y
Sbjct: 657 SRMARLEVIE--LPHSP-----QNLLVSPNSS------HSHAVVLSWVRPFDGNSPILYY 703

Query: 559 IIEAFSHASGSSWQTVAENVKTETS--AIKGLKPNAIYLFLVRAANAYGISDPSQISDPV 616
           I+E     + S W+    NV  E +   + GL P   Y F V A N  G    S  +  +
Sbjct: 704 IVEL--SENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRL 761

Query: 617 KTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY---IQGYKI 673
              +  P++   +     R               ++ SI V W    ++++   ++GY +
Sbjct: 762 MLPEEPPSAPPKNIVASGR---------------TNQSIMVQWQPPPETEHNGVLRGYIL 806

Query: 674 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 733
            YR +G      ++    + +P  N  ++ DL     YEI+   +     G  S      
Sbjct: 807 RYRLAGL---PGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEY 863

Query: 734 TLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKT 793
           TL+  P+APPQ V       N T I   W PPP+   NG+ Q YK+     +    +   
Sbjct: 864 TLQGVPTAPPQNVQTEA--VNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVV 921

Query: 794 VDGSTFSVV----IPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 833
                F  V    I  L     Y   V   T  G G  S PQ +
Sbjct: 922 TIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLV 965



 Score =  191 bits (486), Expect = 4e-48
 Identities = 206/850 (24%), Positives = 325/850 (38%), Gaps = 93/850 (10%)

Query: 22  LRQEDFPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
           L Q+D  P     P    I  +G    L C AEG      +W +    + T   +   ++
Sbjct: 97  LAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSE---YK 153

Query: 81  MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
            ++PS              + D G Y CV RN +G  +   + ++VA +   F       
Sbjct: 154 YIIPS------------LQKLDAGFYRCVVRNRMGALLQRKSEVQVAYM-GSFMDTDQRK 200

Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYV 200
            V+ G  A++   P   +P P ++W ++G  +   +        +L+I  T  SDAG Y 
Sbjct: 201 TVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYY 260

Query: 201 CVGTNMVG--ERESEVAELTVLE--------RPSFVKRPSNLAVTVDDS-AEFKCEARGD 249
               N      + S    L++           P+ V  P N +V    S    +C A   
Sbjct: 261 VQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASAR 320

Query: 250 PVP--TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
           PV   +V W+++   +    +       L I   T+ D G Y C A       E +    
Sbjct: 321 PVEDLSVTWKRNGVRITSGLHSF--GRRLTISNPTSADTGPYVCEAALPGSAFEPARATA 378

Query: 308 VQVGSEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 366
                EPP+F  +P  ++ A +  TV   C+A G P P + W ++     +   Q P   
Sbjct: 379 FLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAIS--ISRLQNP--- 433

Query: 367 SRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 426
            R+ V  +G L I  ++  D G + C   N  G I T  YL+VT++      PV  Q PV
Sbjct: 434 -RYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNI-----APVFTQRPV 487

Query: 427 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ---LENGVLQIRYAKLGD 483
           + TV    T +L C  +G+P P I W+++  ++++   RI +   LE+G LQI    + D
Sbjct: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547

Query: 484 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 543
            G YTC A+   G    SA + V      V PP                      + V  
Sbjct: 548 AGNYTCYAANTEGSLNASATLTVWNRTSIVHPPED--------------------HVVIK 587

Query: 544 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 603
                L+ GAT    +   +       W+   +NV         L P++    +V    +
Sbjct: 588 GTTATLHCGATHDPRVSLRY------VWK--KDNV--------ALTPSSTSRIVVEKDGS 631

Query: 604 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 663
             IS     S  +        S+G +  ++ R     + H     ++S +S   H  V  
Sbjct: 632 LLIS--QTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLS 689

Query: 664 QSQYIQGYK-ILYRPSGANHGESDWLVFEVRT-PAKNSVVIPDLRKGVNYEIKARPFFNE 721
             +   G   ILY     +   S W V      P    V +  L     Y+ +       
Sbjct: 690 WVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEV 749

Query: 722 FQGA-DSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY--K 778
            +G   +E       EE PSAPP+ +  S       +I+V WQPPPE   NG+++ Y  +
Sbjct: 750 GRGQYSAETSRLMLPEEPPSAPPKNIVASGR--TNQSIMVQWQPPPETEHNGVLRGYILR 807

Query: 779 VWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAH 838
               G    Y             ++  L+   +Y ++VAA  GAG GV S     +    
Sbjct: 808 YRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSR-AVTEYTLQ 866

Query: 839 GNPVSPEDQV 848
           G P +P   V
Sbjct: 867 GVPTAPPQNV 876



 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 95/343 (27%), Positives = 145/343 (42%), Gaps = 47/343 (13%)

Query: 521  PNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSS--WQTVAENV 578
            P  +P APS   ++++S  + TL ++P  +   + + +I+E    A G    W T+ E  
Sbjct: 1066 PPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEE 1125

Query: 579  K---TETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT----QDVLPTSQGVDHK 631
                 +   I  L P   Y F ++  N  G S  S  S  ++T     DV PTS  V   
Sbjct: 1126 NEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV--- 1182

Query: 632  QVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY-----IQGYKILYRPSGANHGESD 686
                               S +S+ + W     SQY       GY+I Y  S     +S 
Sbjct: 1183 ----------------RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDL---QSS 1223

Query: 687  WLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGV 746
             +   V    +    I +L + + YE++ + F     G  SE+   +T E  PSA P+ V
Sbjct: 1224 AVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENV 1283

Query: 747  TVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYHINKTVDGSTFSVV 802
              S    + T IL++W   PE  QNG++  YK+      L  E R HI +     T S +
Sbjct: 1284 --SAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR--GNHTQSAL 1339

Query: 803  IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL---DAHGNPV 842
            +  L   + Y ++V A T  G+GV S P  ++    DA G PV
Sbjct: 1340 LAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPV 1382



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 194/873 (22%), Positives = 297/873 (34%), Gaps = 159/873 (18%)

Query: 29   PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
            P   + P D  V+ G  A L C+  G P P I W K    +           MLL SG L
Sbjct: 480  PVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITW-KRENHILASGSVRIPRFMLLESGGL 538

Query: 89   FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL-RDDFRQNPSDVMVAVGEP 147
                +        D G Y C A N  G   S NAS  + +  R      P D +V  G  
Sbjct: 539  QIAPVF-----IQDAGNYTCYAANTEG---SLNASATLTVWNRTSIVHPPEDHVVIKGTT 590

Query: 148  AVMECQPPRGHPEPTIS----WKKDGSPL-DDKDERITI-RGGKLMITYTRKSDAGKYVC 201
            A + C       +P +S    WKKD   L      RI + + G L+I+ T   D G Y C
Sbjct: 591  ATLHCGATH---DPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSC 647

Query: 202  VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDD 260
               +  G  +S +A L V+E P     P NL V+ + S              + W R  D
Sbjct: 648  EIVS-EGGNDSRMARLEVIELP---HSPQNLLVSPNSSHSH--------AVVLSWVRPFD 695

Query: 261  GELPKSRYEIRDDHTLKIRKVTAGDMG-----------------SYTCVAENMVGKAEAS 303
            G  P   Y +         KV   ++G                  +   A N VG+ + S
Sbjct: 696  GNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYS 755

Query: 304  A-TLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362
            A T  + +  EPP     P   +VA GRT                     +Q+++  +QP
Sbjct: 756  AETSRLMLPEEPPS---APPKNIVASGRT---------------------NQSIMVQWQP 791

Query: 363  PQSSSRFSVSQ-----------TGDLTITNVQRSDVGYYICQTL-------------NVA 398
            P  +    V +            G+    N+   +V Y +   L             N A
Sbjct: 792  PPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGA 851

Query: 399  G-SIITKAYLEVT-DVIADRPPPVIRQGPVNQTVA-----VDGTFVLSCVATGSPVPTIL 451
            G  + ++A  E T   +   PP  ++   VN T             ++ +  G  +  + 
Sbjct: 852  GLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKL--LA 909

Query: 452  WRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGV 511
            W  D     T    +  +      + +  + +  ++T            + +  V  F  
Sbjct: 910  WPADAPEAVT----VVTIAPDFHGVHHGHITNLKKFT------------AYFTSVLCFTT 953

Query: 512  PVQPPRPTDPNLIPSAPSKP------EVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSH 565
            P   P P+ P L+ +   KP        T++   ++ +SWQ  L      T Y I    +
Sbjct: 954  PGDGP-PSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVY 1012

Query: 566  ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTS 625
                S  T   N  T    I+GL     Y   V A  A G      ++    +  V P  
Sbjct: 1013 GRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVG---TGLVTSSTISSGVPPDL 1069

Query: 626  QGVDHKQVQRELG--NAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHG 683
             G     V   +   +A L    P     +SI   W V+ Q              GA   
Sbjct: 1070 PGAPSNLVISNISPRSATLQF-RPGYDGKTSIS-RWIVEGQ-------------VGAIGD 1114

Query: 684  ESDWLVF--EVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADS-EIKFAKTLEEAPS 740
            E +W+    E   P    + IP+L    +Y  + +          S   +  +TL+  P 
Sbjct: 1115 EEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPD 1174

Query: 741  APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ----EYKVWCLGNETRYHINKTVDG 796
              P  VTV     + T++ + W P P+   NG  +      K W    ++        D 
Sbjct: 1175 VAPTSVTV--RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDR 1232

Query: 797  STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
                  I  L   + Y +++ A    G+G  SE
Sbjct: 1233 LEREFTIEELEEWMEYELQMQAFNAVGAGPWSE 1265



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 86/342 (25%), Positives = 139/342 (40%), Gaps = 51/342 (14%)

Query: 516  PRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVA 575
            P P    L+P A       +V+  ++ L W P  + GA+P  Y            WQT +
Sbjct: 1477 PAPPRELLVPQA-------EVTARSLRLQWVPG-SDGASPIRYFTMQVRELPRGEWQTYS 1528

Query: 576  ENVKTETSA--IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 633
             ++  E +A  +  L+P   Y   ++A N  G SD S  ++ V T   +P          
Sbjct: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPG--------- 1579

Query: 634  QRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRP------SG----- 679
              E   +V    + T  ++SS+ + W   +       +QGY+I YR       SG     
Sbjct: 1580 --EPPGSV----SATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633

Query: 680  -----ANHGE-SDWLVFEVRTPAKNSVV--IPDLRKGVNYEIKARPFFNEFQGADSEIKF 731
                 A H E +    F+    +  S +  +  L+K   YE+    +    +   S    
Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVE 1693

Query: 732  AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYH 789
                E AP+  PQ V V+      + + V+W PPP ++QNG +Q YK+  W   ++    
Sbjct: 1694 VFVGEAAPAMAPQNVQVTPL--TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETE 1751

Query: 790  INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQ 831
              K +      V +  L    +Y V ++A   AG G KS+PQ
Sbjct: 1752 KMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQ 1793



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 84/332 (25%), Positives = 138/332 (41%), Gaps = 37/332 (11%)

Query: 527  APSKPEVTDVSRNTVTLSWQP----NLNSGATPTSYIIEAFSHASGSSW--QTVAENVKT 580
            AP+   V   S  ++ L W P      N       Y I+ +     SS   Q V++ ++ 
Sbjct: 1176 APTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER 1235

Query: 581  ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 640
            E + I+ L+    Y   ++A NA G    S++    +T++ +P++     + V  E    
Sbjct: 1236 EFT-IEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAP---ENVSAE---- 1286

Query: 641  VLHLHNPTVLSSSSIEVHWT-VDQQSQ--YIQGYKILYRPSGANHGESDWLVFEVRTPAK 697
                     +SS+ I + WT V +Q Q   I GYKIL+R    +      +V   R    
Sbjct: 1287 --------AVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIV---RGNHT 1335

Query: 698  NSVVIPDLRKGVNYEIKARPFFNEFQGADSE-IKFAKTLEEAPSAPPQGVTVSKNDGNGT 756
             S ++  LRK V YE++   F     G  S  +   +T ++AP  P   V +   +   T
Sbjct: 1336 QSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPP---VRLVFPEVRLT 1392

Query: 757  AILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD-GSTF-SVVIPFLVPGIRYSV 814
            ++ + WQPP E   NG++  Y++      +  H   TV+ G+T        L P   Y  
Sbjct: 1393 SVRIVWQPPEE--PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIF 1450

Query: 815  EVAASTGAGSGVKSEPQFIQLDAHGNPVSPED 846
             ++A T  G G   E   I  +    P  P +
Sbjct: 1451 RLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 87/398 (21%), Positives = 150/398 (37%), Gaps = 53/398 (13%)

Query: 527  APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENV---KTETS 583
            AP   +VT ++ + + ++W P             + +   + S  +T    V        
Sbjct: 1704 APQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVV 1763

Query: 584  AIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 643
             +K L  +  YL  + A NA G    S   DP          QG  H+            
Sbjct: 1764 RLKNLTSHTKYLVSISAFNAAGDGPKS---DP---------QQGRTHQAAPGAPSFLAF- 1810

Query: 644  LHNPTVLSSSSIEVHWTVDQQSQYI-QGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 702
                + ++S+++ V W     +  I QGY+++Y P     G S  +  EVR   +  + +
Sbjct: 1811 ----SEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKV 1866

Query: 703  PDLRKGVNY--EIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILV 760
             DL KGV Y   ++AR       G + +        E     P+ V V+K   + + + +
Sbjct: 1867 RDLTKGVTYFFRVQARTI---TYGPELQANITAGPAEGSPGSPRDVLVTK---SASELTL 1920

Query: 761  SWQP--PPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAA 818
             W      +    G V E +    G    +  +     +++++ +  L  G+ Y   V A
Sbjct: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980

Query: 819  STGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAF--IAGIGAACWIILM 876
               AG              +G P +P   VS AQ  +   ++  F  +  + +   I+L+
Sbjct: 1981 VNEAG--------------YGEPSNPSTAVS-AQVEAPFYEEWWFLLVMALSSLIVILLV 2025

Query: 877  VFSIWLYRHRKKRNGLTSTYAGI----RKVTYQRGGEA 910
            VF++ L+   KK     ST  GI      VT   GG A
Sbjct: 2026 VFALVLHGQNKKYKN-CSTGKGISTMEESVTLDNGGFA 2062


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  201 bits (512), Expect = 4e-51
 Identities = 186/722 (25%), Positives = 301/722 (41%), Gaps = 81/722 (11%)

Query: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGGKLMI 188
           F   PSD +   G   +++C        P I WKKDG  L    D++ ++++   G L+I
Sbjct: 42  FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99

Query: 189 -----TYTRKSDAGKYVCVGT-NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
                +   K D G Y C  +    G   S  A++ V     F+ +  ++   + D+   
Sbjct: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159

Query: 243 KCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
           KCE  G+P+PT+ W+K+  +L      SR  +     L+I ++  GD+G Y C A N   
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219

Query: 299 KAEASATLTVQVGSEPP-----HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS 353
               +    V++ S+P      +F+ +P + V   G+    +C  +G P P+  W R G 
Sbjct: 220 SRTGNEA-EVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GE 277

Query: 354 QNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 413
           + +         S ++S+    +L I+NV   D G Y C       +I   A L V    
Sbjct: 278 EVIQL------RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL--- 328

Query: 414 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 473
               PP     P N            C  +G PVPT+ W K+G +V   D   + +    
Sbjct: 329 ---VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSN 384

Query: 474 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV 533
           L+I      D G Y C+A   +G A  SA + V +  +P         +++PSAP     
Sbjct: 385 LRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP-------SSSVLPSAPRDVVP 437

Query: 534 TDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET--SAIKGLKPN 591
             VS   V LSW+P   +     ++ +  F    G + +      +  +    +  LKP 
Sbjct: 438 VLVSSRFVRLSWRPPAEAKGNIQTFTV--FFSREGDNRERALNTTQPGSLQLTVGNLKPE 495

Query: 592 AIYLFLVRAANAYGISDPSQISDPVK--TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTV 649
           A+Y F V A N +G   P + S P+K  TQ  L     V++ Q       ++L    P  
Sbjct: 496 AMYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPA 552

Query: 650 LSSSSIEVHWTVDQQSQYIQGYKIL---YRPSGANHGESDWLVFEVRTPAKNSVVIPDLR 706
            ++               +QGY++           + E D L ++          +  L+
Sbjct: 553 YANGP-------------VQGYRLFCTEVSTGKEQNIEVDGLSYK----------LEGLK 589

Query: 707 KGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPP 766
           K   Y ++   +     G  ++     TL + PSAPPQ V++     N  +I VSW PPP
Sbjct: 590 KFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV--VNSRSIKVSWLPPP 647

Query: 767 EDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
             TQNG +  YK+      TR    +T++ +    +   L  G +YS +V+A T  G+G 
Sbjct: 648 SGTQNGFITGYKI-RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGP 706

Query: 827 KS 828
            S
Sbjct: 707 PS 708



 Score =  192 bits (487), Expect = 3e-48
 Identities = 215/837 (25%), Positives = 320/837 (38%), Gaps = 111/837 (13%)

Query: 30  RIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
           R +  PSD +  +G    L+C AE  R  P I+W K G  +    D+ +     L +GSL
Sbjct: 41  RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97

Query: 89  FFLRIVHGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVA-ILRDDFRQNPSDVMVAVGE 146
               I+H R  +PDEG+Y C A     G  +S  A + VA  LR  F      V   +G+
Sbjct: 98  LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155

Query: 147 PAVMECQPPRGHPEPTISWKK---DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
             +++C+   G P PTI W+K   D +P+      + +  G L I+  +  D G Y C  
Sbjct: 156 TVLLKCE-VIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214

Query: 204 TNMVGERESEVAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
            N    R    AE+ +L  P       F++RPSN+       A  +C   G P P+  W 
Sbjct: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274

Query: 258 KDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
           + +   +L   +Y +     L I  VT  D G YTCV         ASA LTV V   PP
Sbjct: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLV---PP 331

Query: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
            F+  P +        + F+C  +G P P + W + G   +   Y        F +    
Sbjct: 332 WFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--------FQIVGGS 383

Query: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435
           +L I  V +SD G+Y C   N AG+  T A L V       P P I    V  +   D  
Sbjct: 384 NLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-------PKPAIPSSSVLPSAPRDVV 436

Query: 436 FVL------------SCVATGS-PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
            VL               A G+    T+ + ++G     ++  +   + G LQ+    L 
Sbjct: 437 PVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLK 493

Query: 483 DTGRYT--CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRN 539
               YT   +A    G    S  I+V            T P L +P      +    S  
Sbjct: 494 PEAMYTFRVVAYNEWGPGESSQPIKV-----------ATQPELQVPGPVENLQAVSTSPT 542

Query: 540 TVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSAIKGLKPNAIYLFL 597
           ++ ++W+P   +      Y +     ++G       +N++ +  +  ++GLK    Y   
Sbjct: 543 SILITWEPPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLR 597

Query: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
             A N YG   P   +D + T   L        + V  E            V++S SI+V
Sbjct: 598 FLAYNRYG---PGVSTDDI-TVVTLSDVPSAPPQNVSLE------------VVNSRSIKV 641

Query: 658 HW---TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIK 714
            W       Q+ +I GYKI +R +    GE      E   P     +   L KG  Y  +
Sbjct: 642 SWLPPPSGTQNGFITGYKIRHRKT-TRRGE-----METLEPNNLWYLFTGLEKGSQYSFQ 695

Query: 715 ARPFFNEFQGADSEIKFAKTLE---EAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDT 769
                    G  S    A+T E   +    P Q  ++         I++SW PP  P   
Sbjct: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIV 754

Query: 770 QNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 826
             G +  Y     G  + Y     VD       I  L     Y + + A   AG GV
Sbjct: 755 VRGYIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806



 Score =  158 bits (399), Expect = 5e-38
 Identities = 226/858 (26%), Positives = 329/858 (38%), Gaps = 121/858 (14%)

Query: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
           P R +     +    G+   L C+  G P PTI W K  + +     D R   ++LPSG+
Sbjct: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196

Query: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDV 140
           L   R+  G     D G+Y C ARN       + A  EV IL D        F Q PS+V
Sbjct: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249

Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKY 199
           +   G+ AV+EC    G+P P+ +W +    +  + ++ ++ GG  L+I+     D+G Y
Sbjct: 250 VAIEGKDAVLECCVS-GYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308

Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
            CV T    E  S  AELTVL  P F+  PSNL        EF+C   G PVPTV W K+
Sbjct: 309 TCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367

Query: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFV 318
            D  +P   ++I     L+I  V   D G Y CVAEN  G A+ SA L V   + P   V
Sbjct: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427

Query: 319 V--KPRDQVVAL--GRTVTFQ----CEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRF 369
           +   PRD V  L   R V        EA GN Q   +F+ REG                 
Sbjct: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNR----------ERAL 477

Query: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ------ 423
           + +Q G L +T         Y  + +         AY E     + +P  V  Q      
Sbjct: 478 NTTQPGSLQLTVGNLKPEAMYTFRVV---------AYNEWGPGESSQPIKVATQPELQVP 528

Query: 424 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 482
           GPV    AV  T   S + T  P         G  L  T+ S  K+    V  + Y KL 
Sbjct: 529 GPVENLQAV-STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSY-KLE 586

Query: 483 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--IPSA-PSKPEVTDVSRN 539
              ++T  +           ++    +G  V     T   L  +PSA P    +  V+  
Sbjct: 587 GLKKFTEYS---------LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637

Query: 540 TVTLSW--QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFL 597
           ++ +SW   P+       T Y I           +T+  N         GL+  + Y F 
Sbjct: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPN--NLWYLFTGLEKGSQYSFQ 695

Query: 598 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 657
           V A    G   PS        ++ L  SQ  D          + LH+   T    + I +
Sbjct: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQP--------SSLHVRPQT----NCIIM 743

Query: 658 HWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV-IPDLRKGVNYEIKA 715
            WT     +  ++GY I Y   G+ + E+      VR  +K     I  L    +Y I  
Sbjct: 744 SWTPPLNPNIVVRGYIIGY-GVGSPYAET------VRVDSKQRYYSIERLESSSHYVISL 796

Query: 716 RPFFNEFQGA--------------DSEIKFAKTLEEAPSA---------PPQGVTVSKND 752
           + F N  +G                  + +   L++ P++         PP GV      
Sbjct: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856

Query: 753 GNGTAILVSW--QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 810
            +  A+ VSW     P++ +   V+ Y V    + +     K+ D ++ S     L P  
Sbjct: 857 HD--AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914

Query: 811 RYSVEVAASTGAGSGVKS 828
            Y   V  +    S   S
Sbjct: 915 MYEFSVMVTKNRRSSTWS 932



 Score = 74.3 bits (181), Expect = 9e-13
 Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 31/334 (9%)

Query: 515  PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW-QT 573
            P    D + +P  PS   V   + N + +SW P LN       YII    +  GS + +T
Sbjct: 716  PENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAET 771

Query: 574  VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 633
            V  + K    +I+ L+ ++ Y+  ++A N  G   P  + +   T+ +   +  VD+  +
Sbjct: 772  VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP--LYESATTRSITDPTDPVDYYPL 829

Query: 634  QRELGNAVLHLHNPTV---------LSSSSIEVHWT-----VDQQSQYIQGYKILYRPSG 679
              +   +V  L  P +         L+  ++ V W       +Q++  ++ Y + +R S 
Sbjct: 830  LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSF 889

Query: 680  ANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 739
            +   +     ++       S     L+    YE       N      S    A T E AP
Sbjct: 890  SASAK-----YKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944

Query: 740  SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDG 796
            ++ P+ +TV   +G   A++VSWQPP E   NG +  Y ++   ++       I +T+ G
Sbjct: 945  TSAPKDLTVITREGKPRAVIVSWQPPLE--ANGKITAYILFYTLDKNIPIDDWIMETISG 1002

Query: 797  STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 830
               +  I  L     Y   + A    G G  S+P
Sbjct: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score =  201 bits (510), Expect = 6e-51
 Identities = 199/763 (26%), Positives = 319/763 (41%), Gaps = 103/763 (13%)

Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFR---------QNPSDVMVAVGEPAVMEC 152
           D G Y CV  + +  A    +   + +  D            Q P  +  A G    +EC
Sbjct: 190 DVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLEC 249

Query: 153 QPPRGHPEPTISWKK-DGSPLDDKDERITIR--GGKLMITYTRKSDAGKYVCVGTNMVGE 209
               G+P P I+W++ DG P   K   I +R   G L I   ++ DAG Y C+  N  G+
Sbjct: 250 FA-LGNPIPQINWRRSDGLPFSSK---IKLRKFSGVLEIPNFQQEDAGSYECIAENSRGK 305

Query: 210 RESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE 269
             +    LT   +P +V+   ++ + V+DS  ++C A G P P+ RW K+   L      
Sbjct: 306 NVAR-GRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERT 364

Query: 270 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV--VA 327
             ++  L I  ++  D G + C+AEN  G   +SA L  +V +  P F   P  ++  V 
Sbjct: 365 QIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAEL--KVVASAPDFSKNPMKKLVQVQ 422

Query: 328 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 387
           +G  V+  C+   +P+    W++ G  ++       Q   R S+   G L I NV ++D 
Sbjct: 423 VGSLVSLDCKPRASPRALSSWKK-GDVSV-------QEHERISLLNDGGLKIANVTKADA 474

Query: 388 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 447
           G Y C   N  G      +L VT+      P  I   P N  V+V  + +L C     P+
Sbjct: 475 GTYTCMAENQFGKANGTTHLVVTE------PTRITLAPSNMDVSVGESVILPCQVQHDPL 528

Query: 448 PTIL--WRKDGVLV-----STQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 500
             I+  W  +G L       +   ++    +G L IR  +L  +G+Y C+  T     + 
Sbjct: 529 LDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSS 588

Query: 501 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 560
           +A + V+                 P  P   +V +++  T  LSW+   ++ +   SY I
Sbjct: 589 AADLIVRG---------------SPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSI 633

Query: 561 EAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDP 615
           +A +  S   WQTV       + KT T+ +  L P   Y F V A+N  G  +PS  S+ 
Sbjct: 634 QARTPFS-VGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEK 692

Query: 616 VKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ-----G 670
           V+T++ +P    V   +V    G            S S + + W  D   + +Q     G
Sbjct: 693 VRTEEAVPE---VPPSEVNGGGG------------SRSELVITW--DPVPEELQNGEGFG 735

Query: 671 YKILYRPSGANHGESDWLVFEVRTP------AKNSVVIPDLRKGVNYEIKARPFFNEFQG 724
           Y + +RP G     + W+   V +P       +N  ++P       YE+K   + N+ +G
Sbjct: 736 YVVAFRPLGV----TTWIQTVVTSPDTPRYVFRNESIVP----YSPYEVKVGVYNNKGEG 787

Query: 725 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCL 782
             S +    + EE P+  P    VS N  + + I VSW   P    NG +  Y+V  W  
Sbjct: 788 PFSPVTTVFSAEEEPTVAPS--QVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNG 845

Query: 783 GNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 825
           G +        V G+  S  +  L   + Y   V A   AG+G
Sbjct: 846 GGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAG 888



 Score =  198 bits (503), Expect = 4e-50
 Identities = 220/860 (25%), Positives = 349/860 (40%), Gaps = 92/860 (10%)

Query: 17  CSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDK 73
           C G  L  +   P  ++ PS+ I    S+ +  TL+C+A G P+P   W   G    +D 
Sbjct: 16  CLGGELLLQG--PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNG----SDI 69

Query: 74  DDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDF 133
           D    HR  L  G+L    +V       D G Y C A N LG  VS  A L+ A L +  
Sbjct: 70  DMSMEHRYKLNGGNL----VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFK 125

Query: 134 RQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL---DDKDERITIRGGKLMITY 190
            +  S V V  G+  V+ C PP    E + +W  +  P    +D    ++   G L I+ 
Sbjct: 126 TKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISK 185

Query: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSA 240
              SD G Y CV T+MV       +   ++ R             V+ P  L      + 
Sbjct: 186 VEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTV 245

Query: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGK 299
           + +C A G+P+P + WR+ DG    S+ ++R     L+I      D GSY C+AEN  GK
Sbjct: 246 KLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGK 305

Query: 300 AEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 359
             A   LT       PH+V   +D  +A+  ++ ++C A+G P+P+  W + G+  +L  
Sbjct: 306 NVARGRLTYYA---KPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVL-- 360

Query: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 419
                   R  + + G LTI+N+  +D G + C   N  G + + A L+V         P
Sbjct: 361 ------EERTQI-ENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVV-----ASAP 408

Query: 420 VIRQGPVNQTVAVD-GTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
              + P+ + V V  G+ V L C    SP     W+K  V V  +  RI  L +G L+I 
Sbjct: 409 DFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQ-EHERISLLNDGGLKIA 467

Query: 478 YAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS 537
                D G YTC+A    G+A  + ++ V            T+P  I  APS  +V+   
Sbjct: 468 NVTKADAGTYTCMAENQFGKANGTTHLVV------------TEPTRITLAPSNMDVSVGE 515

Query: 538 RNTVTLSWQPNLNSGATPTSYIIEAFS--HASGSSWQTVAENVKTETSAIK-GLKPNAIY 594
              +    Q +       T Y   A +     GS ++ V  +   +       LK +  Y
Sbjct: 516 SVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKY 575

Query: 595 LFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSS 654
           + +V+     G+   S  +D      ++  S G        E+ +    L       + S
Sbjct: 576 VCMVQT----GVDSVSSAADL-----IVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHS 626

Query: 655 IEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIK 714
             + +++  ++ +  G++ +              V EV     ++  + +L   V YE +
Sbjct: 627 PVISYSIQARTPFSVGWQTV------------TTVPEVIDGKTHTATVVELNPWVEYEFR 674

Query: 715 ARPFFNEFQGADSEIKFAK--TLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNG 772
                N+  G +  +   K  T E  P  PP    V+   G+ + ++++W P PE+ QNG
Sbjct: 675 V-VASNKIGGGEPSLPSEKVRTEEAVPEVPPS--EVNGGGGSRSELVITWDPVPEELQNG 731

Query: 773 MVQEYKVWC--LGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
               Y V    LG  T    +  + D   +      +VP   Y V+V      G G  S 
Sbjct: 732 EGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFS- 790

Query: 830 PQFIQLDAHGNPVSPEDQVS 849
           P      A   P     QVS
Sbjct: 791 PVTTVFSAEEEPTVAPSQVS 810



 Score =  164 bits (415), Expect = 6e-40
 Identities = 212/853 (24%), Positives = 327/853 (38%), Gaps = 112/853 (13%)

Query: 26   DFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            ++ P+I V+ P  L  +KG    L C A G P P I W +                  LP
Sbjct: 224  EYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDG---------------LP 268

Query: 85   SGSLFFLRIVHGRKSRP-----DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
              S   LR   G    P     D G Y C+A N  G+ V+       A  +  + Q   D
Sbjct: 269  FSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYA--KPHWVQLIKD 326

Query: 140  VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKY 199
            V +AV +    EC+   G P+P+  W K+G+ L   +ER  I  G L I+    +D+G +
Sbjct: 327  VEIAVEDSLYWECRAS-GKPKPSYRWLKNGAALV-LEERTQIENGALTISNLSVTDSGMF 384

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWR 257
             C+  N  G   S      V   P F K P    + V V       C+ R  P     W+
Sbjct: 385  QCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWK 444

Query: 258  KDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPH 316
            K D  + +  R  + +D  LKI  VT  D G+YTC+AEN  GKA  +  L V   +EP  
Sbjct: 445  KGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVV---TEPTR 501

Query: 317  FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 376
              + P +  V++G +V   C+   +P   I +    +  L    +      +   S +GD
Sbjct: 502  ITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGD 561

Query: 377  LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV---- 432
            L I N+Q    G Y+C       S+ + A L V    +  PP  ++   +  T A     
Sbjct: 562  LMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRG--SPGPPENVKVDEITDTTAQLSWK 619

Query: 433  ----DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
                + + V+S         ++ W+    +    D                  G T   T
Sbjct: 620  EGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVID------------------GKTHTAT 661

Query: 489  CIASTPSGEATW----SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 544
             +   P  E  +    S  I   E  +P +  R T+  +    PS+      SR+ + ++
Sbjct: 662  VVELNPWVEYEFRVVASNKIGGGEPSLPSEKVR-TEEAVPEVPPSEVNGGGGSRSELVIT 720

Query: 545  WQP---NLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKG--LKPNAIYLFLV 598
            W P    L +G     Y++ AF     ++W QTV  +  T     +   + P + Y   V
Sbjct: 721  WDPVPEELQNGEG-FGYVV-AFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKV 778

Query: 599  RAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVH 658
               N  G    S ++     ++  PT   V   QV            +   LSSS IEV 
Sbjct: 779  GVYNNKGEGPFSPVTTVFSAEEE-PT---VAPSQV------------SANSLSSSEIEVS 822

Query: 659  WTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKA 715
            W        + ++ GY++ Y   G     S  +        + S  +  L+  + Y    
Sbjct: 823  WNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGN---ETSARLRGLKSNLAYYTAV 879

Query: 716  RPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 775
            R + +   G  S      T +  PS PP  V  +  D   T +L++W+          V 
Sbjct: 880  RAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATD---TKVLLNWEQVKAMENESEVT 936

Query: 776  EYKVW----CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE-- 829
             YKV+       N    + NKT    +  +V+P       Y +EV A+T  G G  SE  
Sbjct: 937  GYKVFYRTSSQNNVQVLNTNKT----SAELVLPIKED---YIIEVKATTDGGDGTSSEQI 989

Query: 830  --PQFIQLDAHGN 840
              P+   +DA G+
Sbjct: 990  RIPRITSMDARGS 1002


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  201 bits (510), Expect = 6e-51
 Identities = 140/403 (34%), Positives = 186/403 (46%), Gaps = 24/403 (5%)

Query: 111 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170
           R   G +V+     E+   R      P D  V  G      C+   G+P+P I W ++ +
Sbjct: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284

Query: 171 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 225
            L  K D R+ +   G LMI  T+++D G Y C+  N+ GE +++   L       RP+F
Sbjct: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344

Query: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 283
           V +P N  V V +S   +C A G P P + W R D   LP   R  I     L I+ V  
Sbjct: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404

Query: 284 GDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQ 343
           GD G Y C A N +    A+A + VQ     P F V P+D+VV  G+TV FQCEA GNP 
Sbjct: 405 GDSGEYACSATNNIDSVHATAFIIVQA---LPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461

Query: 344 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 403
           P I W + GSQ  +          R  V  +G L I+ V   D G Y CQ +N+ GS   
Sbjct: 462 PVIAWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKV 513

Query: 404 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQD 463
            A+L     +  R  PV    P + TV V     L C + G P P I W KDGV V T+ 
Sbjct: 514 VAHL----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TES 568

Query: 464 SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
            +      G L I      D GRY C+A    G A+ S  + V
Sbjct: 569 GKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611



 Score =  189 bits (480), Expect = 2e-47
 Identities = 131/401 (32%), Positives = 180/401 (44%), Gaps = 31/401 (7%)

Query: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
           PRI   P D  V+ G      C+AEG P P I W +    +    D   S   LL  G+L
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302

Query: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 146
                        D+G+Y C+A+N  GE  +   +L    +  R  F   P +  V VGE
Sbjct: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357

Query: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 204
              +EC    GHP P ISW + D +PL   D R+ I   G L I    + D+G+Y C  T
Sbjct: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415

Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
           N + +     A + V   P F   P +  V    + +F+CEA+G+P P + W K   +L 
Sbjct: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474

Query: 265 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRD 323
              R+ +    TL+I  V   D G Y C A N++G  +  A LTVQ     P F   P D
Sbjct: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ-PRVTPVFASIPSD 533

Query: 324 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 383
             V +G  V   C + G P+PAI W ++G Q           S +F +S  G LTI +V 
Sbjct: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVG 585

Query: 384 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424
            +D G Y C   N  GS        V+ V++   P V R G
Sbjct: 586 PADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620



 Score =  147 bits (371), Expect = 8e-35
 Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 24/413 (5%)

Query: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 277
           ERP     P +  VT  ++  F C A G+P P + W +++ EL     SR  + DD TL 
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303

Query: 278 IRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP-PHFVVKPRDQVVALGRTVTFQC 336
           I+     D G Y C+A+N+ G+ +         GS   P FV++P++  V +G +VT +C
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363

Query: 337 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 396
            ATG+P P I W R G +       P     R +++ +G L I NV + D G Y C   N
Sbjct: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416

Query: 397 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 456
              S+   A++ V  +      P     P ++ V    T    C A G+P P I W K G
Sbjct: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470

Query: 457 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 516
             +S  D R   L +G L+I    L D G+Y C A    G     A++ VQ    PV   
Sbjct: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529

Query: 517 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 576
            P+D  +   A  +   +        ++W      G   T        H S   + T+ +
Sbjct: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583

Query: 577 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 629
               +    + +  N I    V    +  + D S+  DP     ++     VD
Sbjct: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636



 Score =  101 bits (252), Expect = 5e-21
 Identities = 69/205 (33%), Positives = 95/205 (46%), Gaps = 9/205 (4%)

Query: 304 ATLTVQ-VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 362
           AT+T + +  E P    +P+D  V  G TV F C A GNP+P I W R  ++  +     
Sbjct: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288

Query: 363 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 422
            ++ SR ++   G L I N Q +D G Y C   NVAG + T+           RP  VI+
Sbjct: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347

Query: 423 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 482
             P N  V V  +  L C ATG P P I W +        D R+    +G L I+    G
Sbjct: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405

Query: 483 DTGRYTCIASTPSGEATWSAYIEVQ 507
           D+G Y C A+        +A+I VQ
Sbjct: 406 DSGEYACSATNNIDSVHATAFIIVQ 430


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  199 bits (505), Expect = 2e-50
 Identities = 220/856 (25%), Positives = 350/856 (40%), Gaps = 93/856 (10%)

Query: 21  RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
           RL  E  P    E    + V +GE   L C       P   ++   + +   +D+  +  
Sbjct: 124 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 181

Query: 81  MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------- 132
            +  +G+L+F  ++    +  +   Y+C A       +     +++ +   +        
Sbjct: 182 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 236

Query: 133 --FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK--LM 187
             F  N S  +VA+ G+P V+EC    G P PTI W +   P+    +R+T +     L 
Sbjct: 237 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQ 293

Query: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
           +    + D G+Y C+  N +G        +TV   P ++ +P +      ++A   C+ +
Sbjct: 294 LLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQ 352

Query: 248 GDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
           G P P V WR +     EL K +        L +  V   D     C A N  G   A+A
Sbjct: 353 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 412

Query: 305 TLTVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
              + V   P   +       +A+ G T    C+A G P P++ W  E    +L      
Sbjct: 413 Y--IYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL------ 464

Query: 364 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ 423
               RF     G L I ++Q +D G Y C   N   ++   A L+V D         I Q
Sbjct: 465 -QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQ 517

Query: 424 GPVNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAK 480
           GP +           +C A+  P   P+I WR DG  L    DS    +E+G L I    
Sbjct: 518 GPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLD 577

Query: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
             D G Y+C+AST        A + V      V  P P  P L+ S     ++  ++++ 
Sbjct: 578 YSDQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS-----DLHLLTQSQ 625

Query: 541 VTLSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVR 599
           V +SW P  +  A    Y IE      +   W ++ +    +TS    L P   Y F V 
Sbjct: 626 VRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVT 685

Query: 600 AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
           A N YG  +PS +S+ V T +  P    VD K    E  N V+          +   + W
Sbjct: 686 AINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRW 735

Query: 660 TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
            +D  +  +Q Y++ +RP G       W    V  P    +V+ +    V YEIK +   
Sbjct: 736 -MDWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVN 787

Query: 720 NEFQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
           ++ +G + ++    + E+ P A P  +G+ +     N +A+LV W+P       G ++ Y
Sbjct: 788 SQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLAQVKGHLRGY 843

Query: 778 KV--WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
            V  W  G++ ++   HI+K    V  +T SV++  L P   Y +EV A  G GSG  SE
Sbjct: 844 NVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE 903

Query: 830 PQFIQLDAHGNPVSPE 845
             F      G P  PE
Sbjct: 904 --FTFSTPEGVPGHPE 917



 Score =  187 bits (474), Expect = 9e-47
 Identities = 148/512 (28%), Positives = 227/512 (44%), Gaps = 38/512 (7%)

Query: 28  PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
           PP I E  P  L+V   +  +L C+A G+P     W + G   +  ++   +      SG
Sbjct: 29  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88

Query: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
           S F +   +   ++  +G+Y C A N LG A+SH   L         ++    V V  GE
Sbjct: 89  S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 147

Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 201
             V+ C PP       I W         +DER+T+ + G L       SD    Y+C   
Sbjct: 148 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 207

Query: 202 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 250
             GT  + ++E    +L V    S + R   L    + S+            +C A G P
Sbjct: 208 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 265

Query: 251 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
            PT++W +  G +P  R   ++ + TL++ KV   D G Y C+AEN +G A  +  +TV+
Sbjct: 266 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 325

Query: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
                P+++ KP+  +   G T    C+  G PQP + WR  G        +      ++
Sbjct: 326 AA---PYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKY 377

Query: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
            + Q G L ++NVQ SD     C+  N  G ++  AY+ V  +    P  ++     NQT
Sbjct: 378 RI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQT 430

Query: 430 -VAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
            +AV G T  L C A G+PVP++ W  +      QD R     NG L IR  +  DTGRY
Sbjct: 431 YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRY 490

Query: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 519
            C+A+      T  A ++V++     Q PR T
Sbjct: 491 FCLAANDQNNVTIMANLKVKDATQITQGPRST 522



 Score =  169 bits (427), Expect = 3e-41
 Identities = 201/828 (24%), Positives = 339/828 (40%), Gaps = 90/828 (10%)

Query: 26  DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
           D  PR++      S L+  +G+P  L C AEG PTPTI+W +    +  D+   ++H   
Sbjct: 232 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 291

Query: 83  LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 141
           L       L++        D+G Y C+A N LG A  ++  ++E A     +   P   +
Sbjct: 292 LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 338

Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 199
              GE A ++CQ  +G P+P ++W+ +G P+++  KD++  I+ G L+++  + SD    
Sbjct: 339 YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 397

Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 257
            C   N  G   +  A + V++ P+ +    N         +A   C+A G PVP+V+W 
Sbjct: 398 QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 456

Query: 258 KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
            +DG   L   R+    + TL IR + A D G Y C+A N        A L V+  ++  
Sbjct: 457 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ-- 514

Query: 316 HFVVKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                PR  +   G  VTF C+A+ +P  QP+I WR +G        Q    S ++ + +
Sbjct: 515 -ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-E 567

Query: 374 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
            G L I ++  SD G Y C        + ++A L V          V   GPV + V  D
Sbjct: 568 DGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSD 617

Query: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIAS 492
              +       S  P          +   D   +  E    +     K+      T +  
Sbjct: 618 LHLLTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL 674

Query: 493 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQP 547
           +P    T+     + ++G P +P   ++  + P A  +    DV         + ++W+P
Sbjct: 675 SPYVHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKP 732

Query: 548 N--LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 605
              ++  A    Y ++     +   WQ   + V      +        Y   V+A N+ G
Sbjct: 733 LRWMDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQG 790

Query: 606 ISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VD 662
                Q++             G D+ Q       A+  L    +L+SS++ V W    + 
Sbjct: 791 KGPEPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLA 834

Query: 663 QQSQYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFF 719
           Q   +++GY + Y   G+    S   + +  V  PA   SV++  LR   +Y ++ + F 
Sbjct: 835 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 894

Query: 720 NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEY 777
               G  SE  F+ T E  P  P     +     + T++L+ WQPP        G V  Y
Sbjct: 895 GRGSGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSY 950

Query: 778 KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 825
                G + +   N   D    +  +  L P +RY  ++ A+T  G G
Sbjct: 951 HPLDEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 997


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
           sapiens]
          Length = 1253

 Score =  199 bits (505), Expect = 2e-50
 Identities = 220/856 (25%), Positives = 350/856 (40%), Gaps = 93/856 (10%)

Query: 21  RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
           RL  E  P    E    + V +GE   L C       P   ++   + +   +D+  +  
Sbjct: 129 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 186

Query: 81  MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------- 132
            +  +G+L+F  ++    +  +   Y+C A       +     +++ +   +        
Sbjct: 187 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 241

Query: 133 --FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK--LM 187
             F  N S  +VA+ G+P V+EC    G P PTI W +   P+    +R+T +     L 
Sbjct: 242 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQ 298

Query: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
           +    + D G+Y C+  N +G        +TV   P ++ +P +      ++A   C+ +
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQ 357

Query: 248 GDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
           G P P V WR +     EL K +        L +  V   D     C A N  G   A+A
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417

Query: 305 TLTVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
              + V   P   +       +A+ G T    C+A G P P++ W  E    +L      
Sbjct: 418 Y--IYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL------ 469

Query: 364 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ 423
               RF     G L I ++Q +D G Y C   N   ++   A L+V D         I Q
Sbjct: 470 -QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQ 522

Query: 424 GPVNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAK 480
           GP +           +C A+  P   P+I WR DG  L    DS    +E+G L I    
Sbjct: 523 GPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLD 582

Query: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
             D G Y+C+AST        A + V      V  P P  P L+ S     ++  ++++ 
Sbjct: 583 YSDQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS-----DLHLLTQSQ 630

Query: 541 VTLSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVR 599
           V +SW P  +  A    Y IE      +   W ++ +    +TS    L P   Y F V 
Sbjct: 631 VRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVT 690

Query: 600 AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
           A N YG  +PS +S+ V T +  P    VD K    E  N V+          +   + W
Sbjct: 691 AINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRW 740

Query: 660 TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
            +D  +  +Q Y++ +RP G       W    V  P    +V+ +    V YEIK +   
Sbjct: 741 -MDWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVN 792

Query: 720 NEFQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
           ++ +G + ++    + E+ P A P  +G+ +     N +A+LV W+P       G ++ Y
Sbjct: 793 SQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLAQVKGHLRGY 848

Query: 778 KV--WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
            V  W  G++ ++   HI+K    V  +T SV++  L P   Y +EV A  G GSG  SE
Sbjct: 849 NVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE 908

Query: 830 PQFIQLDAHGNPVSPE 845
             F      G P  PE
Sbjct: 909 --FTFSTPEGVPGHPE 922



 Score =  187 bits (474), Expect = 9e-47
 Identities = 148/512 (28%), Positives = 227/512 (44%), Gaps = 38/512 (7%)

Query: 28  PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
           PP I E  P  L+V   +  +L C+A G+P     W + G   +  ++   +      SG
Sbjct: 34  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
           S F +   +   ++  +G+Y C A N LG A+SH   L         ++    V V  GE
Sbjct: 94  S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152

Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 201
             V+ C PP       I W         +DER+T+ + G L       SD    Y+C   
Sbjct: 153 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212

Query: 202 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 250
             GT  + ++E    +L V    S + R   L    + S+            +C A G P
Sbjct: 213 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270

Query: 251 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
            PT++W +  G +P  R   ++ + TL++ KV   D G Y C+AEN +G A  +  +TV+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330

Query: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
                P+++ KP+  +   G T    C+  G PQP + WR  G        +      ++
Sbjct: 331 AA---PYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKY 382

Query: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
            + Q G L ++NVQ SD     C+  N  G ++  AY+ V  +    P  ++     NQT
Sbjct: 383 RI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQT 435

Query: 430 -VAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
            +AV G T  L C A G+PVP++ W  +      QD R     NG L IR  +  DTGRY
Sbjct: 436 YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRY 495

Query: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 519
            C+A+      T  A ++V++     Q PR T
Sbjct: 496 FCLAANDQNNVTIMANLKVKDATQITQGPRST 527



 Score =  169 bits (427), Expect = 3e-41
 Identities = 201/828 (24%), Positives = 339/828 (40%), Gaps = 90/828 (10%)

Query: 26   DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
            D  PR++      S L+  +G+P  L C AEG PTPTI+W +    +  D+   ++H   
Sbjct: 237  DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 296

Query: 83   LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 141
            L       L++        D+G Y C+A N LG A  ++  ++E A     +   P   +
Sbjct: 297  LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 343

Query: 142  VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 199
               GE A ++CQ  +G P+P ++W+ +G P+++  KD++  I+ G L+++  + SD    
Sbjct: 344  YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 257
             C   N  G   +  A + V++ P+ +    N         +A   C+A G PVP+V+W 
Sbjct: 403  QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461

Query: 258  KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
             +DG   L   R+    + TL IR + A D G Y C+A N        A L V+  ++  
Sbjct: 462  DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ-- 519

Query: 316  HFVVKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                 PR  +   G  VTF C+A+ +P  QP+I WR +G        Q    S ++ + +
Sbjct: 520  -ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-E 572

Query: 374  TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
             G L I ++  SD G Y C        + ++A L V          V   GPV + V  D
Sbjct: 573  DGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSD 622

Query: 434  GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIAS 492
               +       S  P          +   D   +  E    +     K+      T +  
Sbjct: 623  LHLLTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL 679

Query: 493  TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQP 547
            +P    T+     + ++G P +P   ++  + P A  +    DV         + ++W+P
Sbjct: 680  SPYVHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKP 737

Query: 548  N--LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 605
               ++  A    Y ++     +   WQ   + V      +        Y   V+A N+ G
Sbjct: 738  LRWMDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQG 795

Query: 606  ISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VD 662
                 Q++             G D+ Q       A+  L    +L+SS++ V W    + 
Sbjct: 796  KGPEPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLA 839

Query: 663  QQSQYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFF 719
            Q   +++GY + Y   G+    S   + +  V  PA   SV++  LR   +Y ++ + F 
Sbjct: 840  QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 899

Query: 720  NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEY 777
                G  SE  F+ T E  P  P     +     + T++L+ WQPP        G V  Y
Sbjct: 900  GRGSGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSY 955

Query: 778  KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 825
                 G + +   N   D    +  +  L P +RY  ++ A+T  G G
Sbjct: 956  HPLDEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
           sapiens]
          Length = 1257

 Score =  199 bits (505), Expect = 2e-50
 Identities = 220/856 (25%), Positives = 350/856 (40%), Gaps = 93/856 (10%)

Query: 21  RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
           RL  E  P    E    + V +GE   L C       P   ++   + +   +D+  +  
Sbjct: 129 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 186

Query: 81  MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------- 132
            +  +G+L+F  ++    +  +   Y+C A       +     +++ +   +        
Sbjct: 187 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 241

Query: 133 --FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK--LM 187
             F  N S  +VA+ G+P V+EC    G P PTI W +   P+    +R+T +     L 
Sbjct: 242 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQ 298

Query: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
           +    + D G+Y C+  N +G        +TV   P ++ +P +      ++A   C+ +
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQ 357

Query: 248 GDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
           G P P V WR +     EL K +        L +  V   D     C A N  G   A+A
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417

Query: 305 TLTVQVGSEPPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 363
              + V   P   +       +A+ G T    C+A G P P++ W  E    +L      
Sbjct: 418 Y--IYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL------ 469

Query: 364 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ 423
               RF     G L I ++Q +D G Y C   N   ++   A L+V D         I Q
Sbjct: 470 -QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQ 522

Query: 424 GPVNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAK 480
           GP +           +C A+  P   P+I WR DG  L    DS    +E+G L I    
Sbjct: 523 GPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLD 582

Query: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
             D G Y+C+AST        A + V      V  P P  P L+ S     ++  ++++ 
Sbjct: 583 YSDQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS-----DLHLLTQSQ 630

Query: 541 VTLSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVR 599
           V +SW P  +  A    Y IE      +   W ++ +    +TS    L P   Y F V 
Sbjct: 631 VRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVT 690

Query: 600 AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
           A N YG  +PS +S+ V T +  P    VD K    E  N V+          +   + W
Sbjct: 691 AINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRW 740

Query: 660 TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFF 719
            +D  +  +Q Y++ +RP G       W    V  P    +V+ +    V YEIK +   
Sbjct: 741 -MDWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVN 792

Query: 720 NEFQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 777
           ++ +G + ++    + E+ P A P  +G+ +     N +A+LV W+P       G ++ Y
Sbjct: 793 SQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLAQVKGHLRGY 848

Query: 778 KV--WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 829
            V  W  G++ ++   HI+K    V  +T SV++  L P   Y +EV A  G GSG  SE
Sbjct: 849 NVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE 908

Query: 830 PQFIQLDAHGNPVSPE 845
             F      G P  PE
Sbjct: 909 --FTFSTPEGVPGHPE 922



 Score =  187 bits (474), Expect = 9e-47
 Identities = 148/512 (28%), Positives = 227/512 (44%), Gaps = 38/512 (7%)

Query: 28  PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
           PP I E  P  L+V   +  +L C+A G+P     W + G   +  ++   +      SG
Sbjct: 34  PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93

Query: 87  SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
           S F +   +   ++  +G+Y C A N LG A+SH   L         ++    V V  GE
Sbjct: 94  S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152

Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 201
             V+ C PP       I W         +DER+T+ + G L       SD    Y+C   
Sbjct: 153 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212

Query: 202 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 250
             GT  + ++E    +L V    S + R   L    + S+            +C A G P
Sbjct: 213 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270

Query: 251 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
            PT++W +  G +P  R   ++ + TL++ KV   D G Y C+AEN +G A  +  +TV+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330

Query: 310 VGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 369
                P+++ KP+  +   G T    C+  G PQP + WR  G        +      ++
Sbjct: 331 AA---PYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKY 382

Query: 370 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 429
            + Q G L ++NVQ SD     C+  N  G ++  AY+ V  +    P  ++     NQT
Sbjct: 383 RI-QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQT 435

Query: 430 -VAVDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 487
            +AV G T  L C A G+PVP++ W  +      QD R     NG L IR  +  DTGRY
Sbjct: 436 YMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRY 495

Query: 488 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPT 519
            C+A+      T  A ++V++     Q PR T
Sbjct: 496 FCLAANDQNNVTIMANLKVKDATQITQGPRST 527



 Score =  169 bits (427), Expect = 3e-41
 Identities = 201/828 (24%), Positives = 339/828 (40%), Gaps = 90/828 (10%)

Query: 26   DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
            D  PR++      S L+  +G+P  L C AEG PTPTI+W +    +  D+   ++H   
Sbjct: 237  DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 296

Query: 83   LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 141
            L       L++        D+G Y C+A N LG A  ++  ++E A     +   P   +
Sbjct: 297  LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 343

Query: 142  VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 199
               GE A ++CQ  +G P+P ++W+ +G P+++  KD++  I+ G L+++  + SD    
Sbjct: 344  YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402

Query: 200  VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 257
             C   N  G   +  A + V++ P+ +    N         +A   C+A G PVP+V+W 
Sbjct: 403  QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461

Query: 258  KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315
             +DG   L   R+    + TL IR + A D G Y C+A N        A L V+  ++  
Sbjct: 462  DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ-- 519

Query: 316  HFVVKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 373
                 PR  +   G  VTF C+A+ +P  QP+I WR +G        Q    S ++ + +
Sbjct: 520  -ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-E 572

Query: 374  TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 433
             G L I ++  SD G Y C        + ++A L V          V   GPV + V  D
Sbjct: 573  DGRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSD 622

Query: 434  GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIAS 492
               +       S  P          +   D   +  E    +     K+      T +  
Sbjct: 623  LHLLTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKL 679

Query: 493  TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQP 547
            +P    T+     + ++G P +P   ++  + P A  +    DV         + ++W+P
Sbjct: 680  SPYVHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKP 737

Query: 548  N--LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 605
               ++  A    Y ++     +   WQ   + V      +        Y   V+A N+ G
Sbjct: 738  LRWMDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQG 795

Query: 606  ISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VD 662
                 Q++             G D+ Q       A+  L    +L+SS++ V W    + 
Sbjct: 796  KGPEPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLA 839

Query: 663  QQSQYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFF 719
            Q   +++GY + Y   G+    S   + +  V  PA   SV++  LR   +Y ++ + F 
Sbjct: 840  QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 899

Query: 720  NEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEY 777
                G  SE  F+ T E  P  P     +     + T++L+ WQPP        G V  Y
Sbjct: 900  GRGSGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSY 955

Query: 778  KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 825
                 G + +   N   D    +  +  L P +RY  ++ A+T  G G
Sbjct: 956  HPLDEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002


>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
          Length = 1007

 Score =  197 bits (500), Expect = 9e-50
 Identities = 277/1075 (25%), Positives = 417/1075 (38%), Gaps = 145/1075 (13%)

Query: 413  IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 463
            +A   PP I   P +Q     G   +SC A+G P PTI W  +G  +S           D
Sbjct: 26   MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85

Query: 464  SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 515
              +  L+    G      A   D G YTC AS   G A       S  +  ++F +    
Sbjct: 86   GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141

Query: 516  PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 574
             +P D   +       E          T+SW  +    A      ++   H        +
Sbjct: 142  -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194

Query: 575  AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 634
            A   K++      +  N+      RAA    I +P   ++PV                  
Sbjct: 195  ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235

Query: 635  RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 684
             EL    + L N T+L+    E         + W V   +   Q Y  L+R   A  G+ 
Sbjct: 236  -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294

Query: 685  SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 744
            + W   E       S  +  L  G +YE K RP     +G DS +   +  E+ PSAPPQ
Sbjct: 295  APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352

Query: 745  GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 804
             VT+    GNGT + VSW PPP +  NG+++ Y+VW LGN +    N TV G    + I 
Sbjct: 353  EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409

Query: 805  FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 861
              +PG  Y V+VAA TGAG+G  S P  + L+      + E         +Q+   +K+P
Sbjct: 410  THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468

Query: 862  AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVTYQRGGEAVSSGGRPGLLN 921
              IA  G A W++L+  ++ ++R R+ R  L     G+ + T +   +A+       L +
Sbjct: 469  EVIATCGVALWLLLLGTAVCIHRRRRARVHLG---PGLYRYTSE---DAI-------LKH 515

Query: 922  ISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNK 981
              + +   WLADTW +T  +  D S S   +    +D+       P DC  +  +     
Sbjct: 516  RMDHSDSQWLADTWRSTSGS-RDLSSSSSLSSRLGADAR-----DPLDCRRSLLSWDSRS 569

Query: 982  QTNLMLPE-STVYGDVDLSNKINEMKTFNSPNLKDGRFVNP--SGQPTPYATTQLIQSNL 1038
                +LP+ ST YG + ++   +      SP +   R + P  +   +P +++  + S  
Sbjct: 570  PGVPLLPDTSTFYGSL-IAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCSSSDSLCSRR 628

Query: 1039 SNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQSYD 1098
              +    S    E  WK   ++KQE+     + + +   + + RA +             
Sbjct: 629  GLSSPRLSLAPAEA-WK--AKKKQELQHANSSPLLRGSHSLELRACEL------------ 673

Query: 1099 QNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP--AHPPPHSNSEE 1156
             N G    S   G+        +  A  PK+           LPP P   H  P + S++
Sbjct: 674  GNRGSKNLSQSPGAVPQALVAWR--ALGPKLLSSSNELVTRHLPPAPLFPHETPPTQSQQ 731

Query: 1157 YNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQSTA 1216
                V       +  P  P  +         +        P     SS +  S      +
Sbjct: 732  TQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSLSSLGEDQDS 791

Query: 1217 TLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSD 1276
             LTP   EE+   L+        +    +  R  VS  P PR  SPP TYGYIS P  S+
Sbjct: 792  VLTP---EEVALCLE--------LSEGEETPRNSVS--PMPRAPSPPTTYGYISVPTASE 838

Query: 1277 MDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEED 1336
              TD               +   R  L     TP  S         GS+ NGWGSASE++
Sbjct: 839  F-TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLANGWGSASEDN 884

Query: 1337 NISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPT 1396
              S+  S VSSSDGSF  DA FA+A+A A +  G  +  R+    A      AS  P P 
Sbjct: 885  AASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFIDASSPPSPR 940

Query: 1397 SPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1451
              +    N+S  + +  RP      +  H +R      +PP P P   I S  +Q
Sbjct: 941  DEIFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISSQRSQ 991



 Score =  176 bits (446), Expect = 2e-43
 Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)

Query: 25  EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
           +D PP+I+ HP D +     PA ++C+A G+P PTI W   G+ +     DP     LLP
Sbjct: 28  QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84

Query: 85  SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
            G+L  L+         G+    D GVY C A N LG AVS  A L VA+LR+DF+  P 
Sbjct: 85  DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144

Query: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
           D++  VGE   +EC PP GHPEPT+SW KDG PL  +  R T+ GG L++    KSD G 
Sbjct: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204

Query: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
           Y+CV TN  G RES  A +++ E   + +    LAV +
Sbjct: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 103/425 (24%), Positives = 160/425 (37%), Gaps = 59/425 (13%)

Query: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 279
           P  +  P +        A   C+A G P PT+RW  +   L   P   + +  D TL + 
Sbjct: 32  PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91

Query: 280 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQVGSEPPHFVVKPRDQVVA 327
           +  A            D+G YTC A N +G A    A L+V V  E   F ++PRD V  
Sbjct: 92  QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRE--DFQIQPRDMVAV 149

Query: 328 LGRTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 386
           +G   T +C    G+P+P + W ++G      + QP     R +VS  G L +   ++SD
Sbjct: 150 VGEQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSD 201

Query: 387 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSP 446
            G Y+C   N AG   ++A         D   PV     +   + ++   +L+      P
Sbjct: 202 EGTYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGP 258

Query: 447 VPT----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATW 500
            P     + W+  G     Q          + + + A  G    +    +A   S E   
Sbjct: 259 KPRPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGG 312

Query: 501 SAYIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPN 548
             + +  EF V     R   P+           +PSAP +         TV +SW   P 
Sbjct: 313 LHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPA 372

Query: 549 LNSGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGI 606
            N       Y + +  + S   ++W  V E  + E   I    P + Y   V A    G 
Sbjct: 373 ENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGA 428

Query: 607 SDPSQ 611
            +PS+
Sbjct: 429 GEPSR 433



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 65/227 (28%), Positives = 90/227 (39%), Gaps = 25/227 (11%)

Query: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 190
           +P D +     PA M CQ   G P PTI W  +G PL     D    +  G L++     
Sbjct: 37  HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95

Query: 191 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 241
                      +D G Y C  +N +G   S  A L+V + R  F  +P ++   V +   
Sbjct: 96  RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155

Query: 242 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
            +C    G P PTV W KD   L     R+ +     L  R     D G+Y CVA N  G
Sbjct: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214

Query: 299 KAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 345
             E+ A    +V  + P    +P   V  L   +  +     NP PA
Sbjct: 215 HRESRA---ARVSIQEPQDYTEP---VELLAVRIQLENVTLLNPDPA 255



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)

Query: 314 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 359
           PP  +V P+DQ+          C+A+G P P I W   G                  L  
Sbjct: 31  PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90

Query: 360 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 418
            QPP           G         +D+G Y C+  N  G+ +++ A L V  +  D   
Sbjct: 91  LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138

Query: 419 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
              +  P +    V   F L C    G P PT+ W KDG  ++ Q  R   +  G L + 
Sbjct: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195

Query: 478 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 526
            A+  D G Y C+A+  +G   + +A + +QE            V +Q    T  N  P+
Sbjct: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255

Query: 527 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 582
              KP      R  V LSW+  ++  A P       F    A G      AE +    ++
Sbjct: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307

Query: 583 SAIKGLKPNAIYLFLVRAAN 602
           + + GL     Y F VR ++
Sbjct: 308 AELGGLHWGQDYEFKVRPSS 327


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score =  189 bits (479), Expect = 2e-47
 Identities = 206/822 (25%), Positives = 322/822 (39%), Gaps = 85/822 (10%)

Query: 29  PRIVEHPSDLI----VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
           P   + P D+I    +SK E   LNC A G P+P   W + G    TD D   S+   L 
Sbjct: 26  PIFTQEPHDVIFPLDLSKSE-VILNCAANGYPSPHYRWKQNG----TDIDFTMSYHYRLD 80

Query: 85  SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV 144
            GSL     ++   +  D G+Y C+A N LG  +S  A L+ A + D   +  S V V  
Sbjct: 81  GGSL----AINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVRE 136

Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVC 201
           G+  V+ C PP    + + +W  + +PL   +D    ++   G L I     SD G Y C
Sbjct: 137 GQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTC 196

Query: 202 VGTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPV 251
             TN   +R  +     +++R             V+ P  +    D S + +C A G+PV
Sbjct: 197 FITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPV 256

Query: 252 PTVRWRKDDGE-LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
           P + WR+ DG  LP      +    L+I      D G Y C+A N+ G+  A   L   +
Sbjct: 257 PDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQL---I 313

Query: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
              PP +  K ++  +++   + ++C+A+G P P   W + G +             R  
Sbjct: 314 FYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGER--------LNPEERIQ 365

Query: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT- 429
           + + G L IT +  SD G Y C   N    I   A L V         P   + PV +  
Sbjct: 366 I-ENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVL-----ASAPDFSKSPVKKKS 419

Query: 430 -VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 488
            V V G  V+ C     P   I W++ G     Q  RI  LE+G L+I      D G YT
Sbjct: 420 FVQVGGDIVIGCKPNAFPRAAISWKR-GTETLRQSKRIFLLEDGSLKIYNITRSDAGSYT 478

Query: 489 CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 548
           CIA+   G A  +  + V+E  V   PP   D  +  S     +V+      V   W   
Sbjct: 479 CIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVW--F 536

Query: 549 LNSGATPTSYIIEAFSHASGSS-WQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGIS 607
            N         +  F    G S    +  N++   S  K L      L  + A     + 
Sbjct: 537 FNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSG-KYLCTVQTTLESLSAVADIIVR 595

Query: 608 DPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY 667
            P    + V+ +D+  T+  +  +       N+ + +   T+ + +   V W        
Sbjct: 596 GPPGPPEDVQVEDISSTTSQLSWRAGPD--NNSPIQIF--TIQTRTPFSVGWQAVATVPE 651

Query: 668 IQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADS 727
           I   K     +    G S W+ +E R  A NS+ I                     G  S
Sbjct: 652 ILNGKTY---NATVVGLSPWVEYEFRVVAGNSIGI---------------------GEPS 687

Query: 728 E-IKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC--LGN 784
           E  +  +T    P   P  V +    G+ + ++++W+  PE+ QNG    Y +    +G+
Sbjct: 688 EPSELLRTKASVPVVAP--VNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGS 745

Query: 785 ET-RYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 825
            T       +V+ S F      ++P   + V+V      G G
Sbjct: 746 TTWSKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEG 787



 Score =  176 bits (445), Expect = 2e-43
 Identities = 191/717 (26%), Positives = 306/717 (42%), Gaps = 80/717 (11%)

Query: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSD 195
           P  +  A      +EC    G+P P ISW++ DGSPL  K  + +     L I   ++ D
Sbjct: 234 PETIQAAKDSSVKLECFA-LGNPVPDISWRRLDGSPLPGK-VKYSKSQAILEIPNFQQED 291

Query: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
            G Y C+ +N+ G R     +L     P + ++  N  +++ D+  ++C+A G P P   
Sbjct: 292 EGFYECIASNLRG-RNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYT 350

Query: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEP 314
           W K+   L P+ R +I ++ TL I  +   D G Y C AEN      A+A L V   +  
Sbjct: 351 WLKNGERLNPEERIQI-ENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASA-- 407

Query: 315 PHFVVKP--RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
           P F   P  +   V +G  +   C+    P+ AI W+R G++ L       + S R  + 
Sbjct: 408 PDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKR-GTETL-------RQSKRIFLL 459

Query: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 432
           + G L I N+ RSD G Y C   N  G+      L    ++ +R   VI   P    V V
Sbjct: 460 EDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSL----IVKERT--VITVPPSKMDVTV 513

Query: 433 DGTFVLSCVATGSPVPTIL--WRKDGVLVSTQDS-----RIKQLENGVLQIRYAKLGDTG 485
             + VL C  +  P   ++  W  +G ++  +       RI     G L IR  +L  +G
Sbjct: 514 GESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSG 573

Query: 486 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 545
           +Y C   T     +  A I V+       PP P         P   +V D+S  T  LSW
Sbjct: 574 KYLCTVQTTLESLSAVADIIVRG------PPGP---------PEDVQVEDISSTTSQLSW 618

Query: 546 QPNLNSGATPTSYIIEAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYLFLVRA 600
           +   ++ +    + I+  +  S   WQ VA      N KT  + + GL P   Y F V A
Sbjct: 619 RAGPDNNSPIQIFTIQTRTPFS-VGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVA 677

Query: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW- 659
            N+ GI +PS+ S+ ++T+  +P                A +++H     S S + + W 
Sbjct: 678 GNSIGIGEPSEPSELLRTKASVPVV--------------APVNIHGGGG-SRSELVITWE 722

Query: 660 TVDQQSQYIQ--GYKILYRPSGANHGESDWL--VFEVRTPAKNSVVIPDLRKGVNYEIKA 715
           ++ ++ Q  +  GY I++RP G+     + +  V   R   +N  +IP       +E+K 
Sbjct: 723 SIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIP----LSPFEVKV 778

Query: 716 RPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 775
             + NE +G+ S +    + E+ P   P+G   S    + + + VSW     +   G V 
Sbjct: 779 GVYNNEGEGSLSTVTIVYSGEDEPQLAPRG--TSLQSFSASEMEVSWNAIAWNRNTGRVL 836

Query: 776 EYKV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 830
            Y+V  W   ++        V G+  +  I  L     Y   V A   AG+G  S P
Sbjct: 837 GYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPP 893



 Score =  130 bits (328), Expect = 8e-30
 Identities = 195/859 (22%), Positives = 331/859 (38%), Gaps = 126/859 (14%)

Query: 26   DFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
            ++ P+I V  P  +  +K     L C A G P P I W +         D       +  
Sbjct: 224  EYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRR--------LDGSPLPGKVKY 275

Query: 85   SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV 144
            S S   L I + ++   DEG Y C+A N  G  ++    +  A    ++ Q   +  +++
Sbjct: 276  SKSQAILEIPNFQQE--DEGFYECIASNLRGRNLAKGQLIFYA--PPEWEQKIQNTHLSI 331

Query: 145  GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 204
             +  + EC+   G P P  +W K+G  L+  +ERI I  G L+IT    SD+G Y C   
Sbjct: 332  YDNLLWECKAS-GKPNPWYTWLKNGERLNP-EERIQIENGTLIITMLNVSDSGVYQCAAE 389

Query: 205  NMVGERESEVAELTVL-ERPSFVKRP--SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
            N      +  AEL VL   P F K P      V V       C+    P   + W++   
Sbjct: 390  NKYQIIYAN-AELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTE 448

Query: 262  ELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVK 320
             L +S R  + +D +LKI  +T  D GSYTC+A N  G A+ + +L V+   E     V 
Sbjct: 449  TLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVK---ERTVITVP 505

Query: 321  PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 380
            P    V +G ++   C+ + +P   + +    + +++   +      R      GDL I 
Sbjct: 506  PSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIR 565

Query: 381  NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 440
            N+Q    G Y+C       S+       V D+I   PP     GP       D +   S 
Sbjct: 566  NIQLHHSGKYLCTVQTTLESLSA-----VADIIVRGPP-----GPPEDVQVEDISSTTSQ 615

Query: 441  VA------TGSPVP--TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 492
            ++        SP+   TI  R    +     + + ++ NG           T   T +  
Sbjct: 616  LSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNG----------KTYNATVVGL 665

Query: 493  TPSGEATWSAYIEVQEFGVPVQPPRPTDPN-LIPSAPSKPEVTDV-------SRNTVTLS 544
            +P     W  Y      G  +    P++P+ L+ +  S P V  V       SR+ + ++
Sbjct: 666  SP-----WVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVIT 720

Query: 545  WQ--PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAAN 602
            W+  P          YII  F     ++W       K + S+++  +      F+ R  +
Sbjct: 721  WESIPEELQNGEGFGYII-MFRPVGSTTWS------KEKVSSVESSR------FVYRNES 767

Query: 603  AYGISDPSQISDPVKTQD---VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW 659
               +S P ++   V   +    L T   V   + + +L      L +    S+S +EV W
Sbjct: 768  IIPLS-PFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQS---FSASEMEVSW 823

Query: 660  TV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKAR 716
                 ++ +  + GY++LY    +       +        KN   I  L+    Y    R
Sbjct: 824  NAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKN---ITGLKANTIYFASVR 880

Query: 717  PFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGN-----------GTAILVSWQPP 765
             +               T    PS+PP  VT  K+  +            + + ++W+  
Sbjct: 881  AY--------------NTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHV 926

Query: 766  PEDTQNGMVQEYKVWCLGN-ETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGS 824
                    V  YK+    N +++ HI +T + ++  +++PF      Y +E+   +  G 
Sbjct: 927  KTMENESEVLGYKILYRQNRQSKTHILET-NNTSAELLVPFEED---YLIEIRTVSDGGD 982

Query: 825  GVKSE----PQFIQLDAHG 839
            G  SE    P+   L + G
Sbjct: 983  GSSSEEIRIPKMSSLSSRG 1001


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  188 bits (477), Expect = 4e-47
 Identities = 126/376 (33%), Positives = 185/376 (49%), Gaps = 24/376 (6%)

Query: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 194
           P DV V  G      C+   G+P+P I W  +   LD + D R+ +   G LMI  TR+S
Sbjct: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298

Query: 195 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
           D G Y C+  N  GE +++ A L   ++  +PSFV +P +  V +  S   +C A G P 
Sbjct: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358

Query: 252 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
           P + W +D+G EL  SR+ +     L ++ +T  D G +TC A N  G  +A+A + VQ 
Sbjct: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417

Query: 311 GSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 370
              PP F V P+DQVV     V + CEA GNP P I W + G Q  +          + +
Sbjct: 418 ---PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHT 466

Query: 371 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV 430
           V  +G L I    + D G Y CQ ++  G  + K  +++T  +  +   V  Q P + +V
Sbjct: 467 VLSSGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSV 522

Query: 431 AVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 490
            V     +SC A G P P I W K+GV + T+  +    + G L I  A   D GRY C+
Sbjct: 523 EVGKNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECV 581

Query: 491 ASTPSGEATWSAYIEV 506
           A    G A  + ++ V
Sbjct: 582 ARNSFGLAVTNMFLTV 597



 Score =  184 bits (467), Expect = 6e-46
 Identities = 123/387 (31%), Positives = 180/387 (46%), Gaps = 23/387 (5%)

Query: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
           PRI   P D+ V  G      C+AEG P P I W      ++ + DD R +  +   G+L
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290

Query: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 146
               I + R+S  D+GVY C+ARN  GEA + +A L  + L  +  F   P D  V +G 
Sbjct: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345

Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
              +EC    GHP P I+W +D     D    +    G  +   T++ D G++ C   N 
Sbjct: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403

Query: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 265
            G  ++  A + V   P F   P +  V  + + E+ CEA G+P P + W K  G+LP +
Sbjct: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462

Query: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQV 325
            ++ +    TL+I +    D G Y C A + +G  + S  LTV+  +    F   P+D  
Sbjct: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAV-FTQLPQDTS 521

Query: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385
           V +G+ +   C A G PQP I W +EG Q           S +F V   G LTI +    
Sbjct: 522 VEVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFP 573

Query: 386 DVGYYICQTLNVAGSIITKAYLEVTDV 412
           D G Y C   N  G  +T  +L VT +
Sbjct: 574 DQGRYECVARNSFGLAVTNMFLTVTAI 600



 Score =  128 bits (322), Expect = 4e-29
 Identities = 94/318 (29%), Positives = 141/318 (44%), Gaps = 24/318 (7%)

Query: 214 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 266
           VA +TV E     P     P ++ V   ++  F C A G+P P + W  ++  L     +
Sbjct: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280

Query: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA-SATLTVQVGSEPPHFVVKPRDQV 325
           R  + DD TL IR     D G Y C+A N  G+A+  SA L        P FV++P+D  
Sbjct: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340

Query: 326 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 385
           V +G + T +C ATG+P P I W R+    L          SR   + +G L + N+ + 
Sbjct: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391

Query: 386 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 445
           D G + C   N  G++   A + V      + PP     P +Q V  +      C A G+
Sbjct: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445

Query: 446 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 505
           P P I+W K G  +  +      L +G L+I  A   D G+Y C A +  G    S  + 
Sbjct: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504

Query: 506 VQEFGVPVQPPRPTDPNL 523
           V+   + V    P D ++
Sbjct: 505 VKPKALAVFTQLPQDTSV 522



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 68/210 (32%), Positives = 96/210 (45%), Gaps = 11/210 (5%)

Query: 298 GKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 357
           G+A AS T+  +   + P    +P+D  V  G TV F C A GNP+P I W        L
Sbjct: 218 GRAVASVTVE-EFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL 276

Query: 358 FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 417
                 +  +R +V   G L I N + SD G Y C   N AG   T++ +     +  +P
Sbjct: 277 ------EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKP 330

Query: 418 PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 477
             VI+  P +  V +  +  L C+ATG P P I W +D  L     SR     +G L ++
Sbjct: 331 SFVIQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQ 386

Query: 478 YAKLGDTGRYTCIASTPSGEATWSAYIEVQ 507
                D GR+TC A+   G    +A I VQ
Sbjct: 387 NITQRDHGRFTCHANNSHGTVQAAANIIVQ 416



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 13/182 (7%)

Query: 28  PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
           PP+    P D +V +       C+A+G P P I W K G ++  +         +L SG+
Sbjct: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472

Query: 88  LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
              LRI   R ++ D+G Y C A + LG + VS   +++   L   F Q P D  V VG+
Sbjct: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526

Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
              + C   +G P+P I+W K+G  + +  +      G L I      D G+Y CV  N 
Sbjct: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585

Query: 207 VG 208
            G
Sbjct: 586 FG 587


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,613,319
Number of Sequences: 37866
Number of extensions: 4149203
Number of successful extensions: 35353
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 294
Number of HSP's successfully gapped in prelim test: 753
Number of HSP's that attempted gapping in prelim test: 18853
Number of HSP's gapped (non-prelim): 8867
length of query: 1606
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1490
effective length of database: 13,855,062
effective search space: 20644042380
effective search space used: 20644042380
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.