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Search of human proteins with 115430237
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
(2564 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 5041 0.0
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 2175 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 2158 0.0
gi|67782321 spectrin beta isoform a [Homo sapiens] 1966 0.0
gi|67782319 spectrin beta isoform b [Homo sapiens] 1966 0.0
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 1962 0.0
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 1265 0.0
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 872 0.0
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 433 e-121
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 433 e-121
gi|12025678 actinin, alpha 4 [Homo sapiens] 409 e-113
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 405 e-112
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 405 e-112
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 405 e-112
gi|4557241 actinin, alpha 3 [Homo sapiens] 403 e-111
gi|4501893 actinin, alpha 2 [Homo sapiens] 398 e-110
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 361 4e-99
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 307 8e-83
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 306 2e-82
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 306 2e-82
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 304 8e-82
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 304 8e-82
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 304 8e-82
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 304 8e-82
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 304 8e-82
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 299 2e-80
gi|221316624 dystonin isoform 4 [Homo sapiens] 295 4e-79
gi|221316622 dystonin isoform 3 [Homo sapiens] 295 4e-79
gi|221316618 dystonin isoform 2 [Homo sapiens] 295 4e-79
gi|34577047 dystonin isoform 1 [Homo sapiens] 293 2e-78
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 5041 bits (13076), Expect = 0.0
Identities = 2564/2564 (100%), Positives = 2564/2564 (100%)
Query: 1 MAQVPGEVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADERE 60
MAQVPGEVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADERE
Sbjct: 1 MAQVPGEVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADERE 60
Query: 61 AVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSL 120
AVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSL
Sbjct: 61 AVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSL 120
Query: 121 ENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETR 180
ENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETR
Sbjct: 121 ENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETR 180
Query: 181 SAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYN 240
SAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYN
Sbjct: 181 SAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYN 240
Query: 241 LQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKV 300
LQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKV
Sbjct: 241 LQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKV 300
Query: 301 LDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKP 360
LDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKP
Sbjct: 301 LDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKP 360
Query: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE
Sbjct: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
Query: 421 LIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAA 480
LIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAA
Sbjct: 421 LIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAA 480
Query: 481 YEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKV 540
YEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKV
Sbjct: 481 YEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKV 540
Query: 541 FQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALR 600
FQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALR
Sbjct: 541 FQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALR 600
Query: 601 FSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWA 660
FSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWA
Sbjct: 601 FSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWA 660
Query: 661 RDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALR 720
RDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALR
Sbjct: 661 RDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALR 720
Query: 721 CGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGA 780
CGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGA
Sbjct: 721 CGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGA 780
Query: 781 DLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLG 840
DLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLG
Sbjct: 781 DLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLG 840
Query: 841 GASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEK 900
GASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEK
Sbjct: 841 GASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEK 900
Query: 901 EQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRS 960
EQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRS
Sbjct: 901 EQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRS 960
Query: 961 CQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGAL 1020
CQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGAL
Sbjct: 961 CQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGAL 1020
Query: 1021 QWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQAC 1080
QWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQAC
Sbjct: 1021 QWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQAC 1080
Query: 1081 GEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVD 1140
GEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVD
Sbjct: 1081 GEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVD 1140
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI
Sbjct: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ
Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
Query: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGW 1320
AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGW
Sbjct: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGW 1320
Query: 1321 IHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 1380
IHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS
Sbjct: 1321 IHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 1380
Query: 1381 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 1440
VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG
Sbjct: 1381 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 1440
Query: 1441 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 1500
DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL
Sbjct: 1441 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 1500
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 1560
LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL
Sbjct: 1501 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 1560
Query: 1561 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 1620
RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA
Sbjct: 1561 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 1620
Query: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 1680
FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL
Sbjct: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 1680
Query: 1681 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740
SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE
Sbjct: 1681 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740
Query: 1741 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 1800
HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT
Sbjct: 1741 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 1800
Query: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860
AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL
Sbjct: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860
Query: 1861 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 1920
TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV
Sbjct: 1861 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 1920
Query: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980
LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL
Sbjct: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980
Query: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH
Sbjct: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
Query: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW
Sbjct: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
Query: 2101 EERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPL 2160
EERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPL
Sbjct: 2101 EERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPL 2160
Query: 2161 ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPAT 2220
ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPAT
Sbjct: 2161 ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPAT 2220
Query: 2221 PAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHS 2280
PAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHS
Sbjct: 2221 PAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHS 2280
Query: 2281 LTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLP 2340
LTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLP
Sbjct: 2281 LTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLP 2340
Query: 2341 AGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRS 2400
AGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRS
Sbjct: 2341 AGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRS 2400
Query: 2401 APAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVSLYCVLSKGELGFYKDS 2460
APAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVSLYCVLSKGELGFYKDS
Sbjct: 2401 APAQGGSAPAPPPPPTHTVQHEGFLLRKRELDANRKSSNRSWVSLYCVLSKGELGFYKDS 2460
Query: 2461 KGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLE 2520
KGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLE
Sbjct: 2461 KGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLE 2520
Query: 2521 AVASSVAEHAEIARWGQTLPTTSSTDEGNPKREGGDRRASGRRK 2564
AVASSVAEHAEIARWGQTLPTTSSTDEGNPKREGGDRRASGRRK
Sbjct: 2521 AVASSVAEHAEIARWGQTLPTTSSTDEGNPKREGGDRRASGRRK 2564
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 2175 bits (5637), Expect = 0.0
Identities = 1123/2139 (52%), Positives = 1510/2139 (70%), Gaps = 55/2139 (2%)
Query: 4 VPGEVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQ 63
V + DN+E + ++ RW+ D W+ E ++A LFE SRIKALADEREAVQ
Sbjct: 5 VATDYDNIE-IQQQYSDVNNRWDVDD--WDNEN-----SSARLFERSRIKALADEREAVQ 56
Query: 64 KKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENV 123
KKTFTKWVNSHLARV C I DLY DLRDG +L +LLEVLSGE+LP+PT+GRMRIH LENV
Sbjct: 57 KKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENV 116
Query: 124 DKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAK 183
DKALQFLKEQRVHLEN+GSHDIVDGNHRLTLGL+WTIILRFQIQ I +ETEDN+E +SAK
Sbjct: 117 DKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAK 176
Query: 184 DALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQR 243
DALLLWCQMKTAGYP VNI NFTTSWRDG+AFNALIH+HRPDL+DF KL KSNA+YNLQ
Sbjct: 177 DALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQN 236
Query: 244 AFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQ 303
AF AEQHLGL +LLDPED++++ PDEKSIITYVV++YHYFSKMKALAVEGKRIGKVLD
Sbjct: 237 AFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDN 296
Query: 304 VLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKF 363
+E K+IE+YE LA++LL WI +T+ +++N+KFANSL GVQQQLQAF Y T+EKP KF
Sbjct: 297 AIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKF 356
Query: 364 QEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIR 423
EKGNLEVLLF+IQSK+RA N+++++PREG I DI+KAW LEKAEHERE ALR ELIR
Sbjct: 357 TEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIR 416
Query: 424 QEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEE 483
QEKLE LA+RFD K AMRE+WL+ENQRLVSQDNFG++LPAVEAA KKHEAIE DIAAYEE
Sbjct: 417 QEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEE 476
Query: 484 RVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQE 543
RVQ V +A+ L AE Y+DI+R+ A++D+V+R W L L+ ARR RLE NL LQK+FQE
Sbjct: 477 RVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQE 536
Query: 544 MVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRF-S 602
M+Y++DWM+EM+ +LS++ G+HL+ +DLLQKH L+E DI Q+ERV +NA+A +F +
Sbjct: 537 MLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFAT 596
Query: 603 QLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARD 662
+GY+PCDPQVI +RV H+ C EL + AA RRA LE SR LW E+ E E W R+
Sbjct: 597 DGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIRE 656
Query: 663 KERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCG 722
KE++L + G DL+S RLL++H+ + E+ GR +QA++ G
Sbjct: 657 KEKILSSDDYG---------------KDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEG 701
Query: 723 EELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADL 782
E+++A G++ + ER R +W LE+ +A R++RL+EA LHQF AD
Sbjct: 702 EDMIAEEHF---GSEKIR-----ERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADA 753
Query: 783 DGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGA 842
D + W+ D ++ ++ D GHDE S++ L ++H+ + E+ +R + L Q + L
Sbjct: 754 DDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQE 813
Query: 843 SGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQ 902
P V + R+ E+ + EV E+ LR+Q L+D LA+Y+MF E ACELWI EKEQ
Sbjct: 814 HAESPDV---RGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQ 870
Query: 903 WLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQ 962
WL +M++P+ L+D+EV+QHRFESL+ EMN+ RV VN ++L+ GHPS E+++ Q
Sbjct: 871 WLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQ 930
Query: 963 DHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG---- 1018
D LN+RW++ ELV+++K+ + + L ++N+ LE E ++ +REK + +ES G
Sbjct: 931 DKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAG 990
Query: 1019 --ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASA 1076
ALQ +L+G+E L A+E + + L +EA L P QA + E+ W + +
Sbjct: 991 VMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTT 1050
Query: 1077 AQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALK 1136
+ ++ A +LQ+FL DLD F WL R Q A + +PN+L EA+ LL +H +K
Sbjct: 1051 LKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASED--MPNTLTEAEKLLTQHENIK 1108
Query: 1137 EEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALV 1196
E+D EEDY ++ E + G + L + L L+ GW++L +WE R+ L
Sbjct: 1109 NEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLS 1166
Query: 1197 QAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQ 1256
Q+H YQ FLRD +QA L NQE L+ E+P T+E E A+K+ DF+TTM+ +++K+
Sbjct: 1167 QSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKIN 1226
Query: 1257 VAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHE 1316
V+ L+ GNI ++ QE V + +++++N+ A + + +L D +LQ FL+DC E
Sbjct: 1227 AVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQE 1286
Query: 1317 LDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPE 1376
L WI+EKML A+D + ++ LH +WL+HQAFMAELA NKEWL+KIE+EG QL+ EKPE
Sbjct: 1287 LSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPE 1346
Query: 1377 LAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDV 1436
A V++KL + + W LESTTQ KA++LF+A+KA+ QS A+LDK L +ESQ+Q
Sbjct: 1347 TEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSD 1406
Query: 1437 DPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGER 1496
D G DL +VN LKK Q +E+Q+E +E+ ELQ+Q AL E S + V ++ V +
Sbjct: 1407 DYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTK 1466
Query: 1497 LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKK 1556
+ LLEPL ER+ LLASKE+HQ D++DE+ WV ER+PLA T+ G+ LQ VQ IKK
Sbjct: 1467 FMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKK 1526
Query: 1557 NQGLRREIQAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQ 1615
NQ L++EIQ H PR++++ ER+ + S AEA+R+ L L+ W L E E+R +
Sbjct: 1527 NQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHR 1586
Query: 1616 VLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEE 1675
L+ A + +QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKKH LEQ VE+Y E
Sbjct: 1587 RLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAE 1646
Query: 1676 SIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQ 1735
++ QLS+ RAL+ HP+SE+IS RQS+VD+LY LK+L EERR L++++ L+QL+R+
Sbjct: 1647 TVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNRE 1706
Query: 1736 VSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELI 1795
V +LE WIAE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+ER+ VN + DELI
Sbjct: 1707 VDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELI 1766
Query: 1796 ECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRR 1855
GH+ AAT+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ DA+E+ G+I++K +
Sbjct: 1767 NSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK 1826
Query: 1856 RLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIAS 1915
+LP + + ++QR FEHD+Q L +QVRQLQE AA+L+ YAG+ A+ I
Sbjct: 1827 KLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQK 1884
Query: 1916 REQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVS 1975
RE EVL+ WK LL ACE R+ + T D RF S VRDL+ WM+ + QI A +KPRDVS
Sbjct: 1885 RENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVS 1944
Query: 1976 SVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSE 2035
SVE+LMN HQG+K E++AR TTC ELG+SLL K ++EI+ +L +L +++E+ +
Sbjct: 1945 SVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMID 2004
Query: 2036 KWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRK 2095
KW+ WEWL+ +LEVHQF+++A VA+AWL QEP L SRE+G SVDEVE+LI+RHEAF K
Sbjct: 2005 KWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEK 2064
Query: 2096 AAAAWEERFSSLRRLTTIEKIKA-------EQSKQPPTP 2127
+AA W+ERFS+L RLTT+E ++ E+ ++PP+P
Sbjct: 2065 SAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSP 2103
Score = 339 bits (870), Expect = 2e-92
Identities = 455/2105 (21%), Positives = 861/2105 (40%), Gaps = 209/2105 (9%)
Query: 515 RQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEMQAQLLSRECGQHLVEADDL 573
R+ AL L+ R+ +LEQ L + F M + W+ E Q + G L +
Sbjct: 406 RELALRNELI--RQEKLEQ---LARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 460
Query: 574 LQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQA 633
+KH +E DIAA ERV+A+ A A +L+ D + I R ++V L E
Sbjct: 461 TKKHEAIETDIAAYEERVQAVVAVA---RELEAENYHDIKRITARKDNVIRLWEYLLELL 517
Query: 634 ARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSS 693
RR LE + L + QE+ W + + L+ + G L
Sbjct: 518 RARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYG---------------KHLLG 562
Query: 694 TARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARR 753
LL +H +++ ++G + ++ ++ G P V + +R A
Sbjct: 563 VEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQV----IRDRVAHMEF 618
Query: 754 RWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLAR 813
+Q L + AA R RL+E+R L +F ++ W+R+ ++ ++ D+G D S RL
Sbjct: 619 CYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLS 678
Query: 814 QHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALR 873
+HRA E+ G ++ + G ++ R++ + +A + +++A+R
Sbjct: 679 KHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGS--EKIRERIIYIREQWANLEQLSAIR 736
Query: 874 RQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSL 933
++ L +A +++ + + + W+L + S DV ++ +SL ++ +
Sbjct: 737 KKRLEEASLLHQFQADAD-------DIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDV 789
Query: 934 MGRVLDVNHTVQELVEGG------HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVL 987
+ + T+ L E H S +VR + R+ + EL RK+ + L
Sbjct: 790 AEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTL 849
Query: 988 LVENHVLEVAEVRAQVREKRRAVESAPRAGG-----ALQWRLSGLEAALQALEPRQAALL 1042
+ E + EK + + + +Q R LE + R A +
Sbjct: 850 ALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVN 909
Query: 1043 EEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLD 1102
+ A L + ++L W +A+ +A +Q + + +
Sbjct: 910 QIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKS 969
Query: 1103 WLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGA 1162
W +R + S L N L AL + ++ ++ E + + +E L +
Sbjct: 970 W-IREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL---ESE 1025
Query: 1163 ELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMAL 1222
A+ L + W ++ + R +L +A Q FLRDL L + A+
Sbjct: 1026 HPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAI 1085
Query: 1223 SGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGE-------- 1274
+ ++P T+ E+ L QH + ++ ++ Q E ++ QG +
Sbjct: 1086 ASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGE-MVTQGQTDAQYMFLRQRL 1144
Query: 1275 QAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIH-EKMLMARDGTR 1333
QA + L K EN+ Q + + H Q FLRD + + +++ ++ ++A
Sbjct: 1145 QALDTGWNELHKMWENR---QNLLSQSH---AYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
+ + FM + N+E + + G++L+ + + +++K+ I
Sbjct: 1199 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHR 1258
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLA-TVNSQLKKL 1452
+ T +L + + +Q EL L E L D D A ++S+ K
Sbjct: 1259 KNRETASELLMRLKDNRDLQKFLQDCQELS--LWINEKMLTAQDMSYDEARNLHSKWLKH 1316
Query: 1453 QSMESQV---EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 1509
Q+ +++ +EW ++ + Q + +P ++ +V E+ + + L Q + +
Sbjct: 1317 QAFMAELASNKEWLDKIEKEGMQL--ISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQ 1374
Query: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569
L + + D W+ + G L +V +KK Q L +++
Sbjct: 1375 RLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKK 1434
Query: 1570 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 1629
+EE+ +A AL+ E + L +Q+ + L E R+ L A+ ++ Q+ D
Sbjct: 1435 EIEELQSQAQALSQEGKSTDEVDSKRLT-VQTKFMELLEPLNERKHNLLASKEIHQFNRD 1493
Query: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL-SRQCRALL 1688
V + W+GE+ L S D G + Q+ L+KK+ L++ ++ ++ I + R +
Sbjct: 1494 VEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVT 1553
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
+ +E I +R + + +L+ L E E+R LE+ + Q +E E W++E+E+
Sbjct: 1554 DSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQEL 1613
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEW 1808
S E +D E +V K + + E + +++ L+ H + ++
Sbjct: 1614 YMMSEEKAKD-EQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMR 1672
Query: 1809 KDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
+ +++ +A L +L R L L + + +L+ I E R + +
Sbjct: 1673 QSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAE-REVVAGSHELGQDYE 1731
Query: 1869 SASSMQRTLRAFEHDL----QLLVSQVRQLQEGAAQLRTVYAGEH-AEAIASREQEVLQG 1923
+ +Q R F D Q V V L + + +G A IA + + +
Sbjct: 1732 HVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDAATIAEWKDGLNEA 1786
Query: 1924 WKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNY 1983
W +LL + ++++ + +F+ +++ + ++ + RD ++VE L
Sbjct: 1787 WADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKL-PEELGRDQNTVETLQRM 1845
Query: 1984 HQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEW 2043
H + +++A ++ QE L ++A A + + D + R+ EV E W +
Sbjct: 1846 HTTFEHDIQALGTQVRQLQEDAARL---QAAYAGD---KADDIQKRENEVLEAWKSLLDA 1899
Query: 2044 LQ----QMLEV-HQFAQEAVVADAWLTAQEPL--LQSRELGSSVDEVEQLIRRHEAFRKA 2096
+ ++++ +F ++V D L ++ + ++++E V VE L+ H+ +
Sbjct: 1900 CESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAE 1959
Query: 2097 AAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERG 2156
A + F+ T IE K+ LL RK +
Sbjct: 1960 IDARNDSFT-----TCIELGKS---------LLARKHYA--------------------- 1984
Query: 2157 LEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAE 2216
S E++ ++ + ++ K E + DR + +E + DA+
Sbjct: 1985 ------------SEEIKEKLLQLTEKRK-EMIDKWEDRWEWLRLILE---VHQFSRDASV 2028
Query: 2217 TPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHE 2276
A E E +S D E+L +R ++ E + ER + E
Sbjct: 2029 AEAWLLGQEPYLSSREIGQSVDEVEKLIKRH---------EAFEKSAATWDERFSALERL 2079
Query: 2277 AAHSLTLGRYEQMERRRERRERRLE--RQESSEQEMPIRGDLVKGKATLADIVEQLQEKE 2334
L R +Q E R+RR E + S E E + D KG EQ+ +
Sbjct: 2080 TTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKG--------EQVSQN- 2130
Query: 2335 AGPGLPAGPSLPQPRE-LPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGG 2393
GLPA P+ E + + NG + + P P P
Sbjct: 2131 ---GLPAEQGSPRMAETVDTSEMVNGATEQRTSSKESSPI----PSPT------------ 2171
Query: 2394 GSRRSRSA-PAQGGSAPAPPPPPTHTVQHEGFLLRKRELDA-NRKSSNRSWVSLYCVLSK 2451
R++++A PAQ + T + Q EGFL RK E +A N+K+S+RSW ++YCV++
Sbjct: 2172 SDRKAKTALPAQSAATLPARTQETPSAQMEGFLNRKHEWEAHNKKASSRSWHNVYCVINN 2231
Query: 2452 GELGFYKDSKGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKD 2511
E+GFYKD+K ASG + E +SL +A EVA DYKKKKHVFKL+ DG+E+L QAKD
Sbjct: 2232 QEMGFYKDAKTAASGIPYHSEVPVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD 2291
Query: 2512 EEEMNGWLEAVASSVA----------EHAEIARWGQTLPTT--SSTDEGNPKREGGDRRA 2559
+EEMN W++A++S+++ + + QTLPT+ + T E +P + D+
Sbjct: 2292 DEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSPGKREKDKEK 2351
Query: 2560 SGRRK 2564
++
Sbjct: 2352 DKEKR 2356
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 2158 bits (5591), Expect = 0.0
Identities = 1106/2092 (52%), Positives = 1484/2092 (70%), Gaps = 47/2092 (2%)
Query: 51 RIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRP 110
R K L DEREAVQKKTFTKWVNSHLARV C I DLY DLRDG +L +LLEVLSGE+LP+P
Sbjct: 31 RFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90
Query: 111 TRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIK 170
T+GRMRIH LENVDKALQFLKEQRVHLEN+GSHDIVDGNHRLTLGL+WTIILRFQIQ I
Sbjct: 91 TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDIS 150
Query: 171 IETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFS 230
+ETEDN+E +SAKDALLLWCQMKTAGYP VNI NFTTSWRDG+AFNALIH+HRPDL+DF
Sbjct: 151 VETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFD 210
Query: 231 KLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKAL 290
KL KSNA+YNLQ AF AEQHLGL +LLDPED++++ PDEKSIITYVV++YHYFSKMKAL
Sbjct: 211 KLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKAL 270
Query: 291 AVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQA 350
AVEGKRIGKVLD +E K+IE+YE LA++LL WI +T+ +++N+KFANSL GVQQQLQA
Sbjct: 271 AVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQA 330
Query: 351 FTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAE 410
F Y T+EKP KF EKGNLEVLLF+IQSK+RA N+++++PREG I DI+KAW LEKAE
Sbjct: 331 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAE 390
Query: 411 HEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKK 470
HERE ALR ELIRQEKLE LA+RFD K AMRE+WL+ENQRLVSQDNFG++LPAVEAA KK
Sbjct: 391 HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK 450
Query: 471 HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTR 530
HEAIE DIAAYEERVQ V +A+ L AE Y+DI+R+ A++D+V+R W L L+ ARR R
Sbjct: 451 HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR 510
Query: 531 LEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSER 590
LE NL LQK+FQEM+Y++DWM+EM+ +LS++ G+HL+ +DLLQKH L+E DI Q+ER
Sbjct: 511 LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAER 570
Query: 591 VEALNAAALRF-SQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649
V +NA+A +F + +GY+PCDPQVI +RV H+ C EL + AA RRA LE SR LW
Sbjct: 571 VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKF 630
Query: 650 LQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELG 709
E+ E E W R+KE++L + G DL+S RLL++H+ + E+
Sbjct: 631 FWEMAEEEGWIREKEKILSSDDYG---------------KDLTSVMRLLSKHRAFEDEMS 675
Query: 710 GRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRL 769
GR +QA++ GE+++A G++ + ER R +W LE+ +A R++RL
Sbjct: 676 GRSGHFEQAIKEGEDMIAEEHF---GSEKIR-----ERIIYIREQWANLEQLSAIRKKRL 727
Query: 770 QEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPV 829
+EA LHQF AD D + W+ D ++ ++ D GHDE S++ L ++H+ + E+ +R +
Sbjct: 728 EEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTL 787
Query: 830 SGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGE 889
L Q + L P V + R+ E+ + EV E+ LR+Q L+D LA+Y+MF E
Sbjct: 788 DTLHEQASALPQEHAESPDV---RGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE 844
Query: 890 VHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVE 949
ACELWI EKEQWL +M++P+ L+D+EV+QHRFESL+ EMN+ RV VN ++L+
Sbjct: 845 ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMH 904
Query: 950 GGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRA 1009
GHPS E+++ QD LN+RW++ ELV+++K+ + + L ++N+ LE E ++ +REK +
Sbjct: 905 SGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKV 964
Query: 1010 VESAPRAGG------ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGA 1063
+ES G ALQ +L+G+E L A+E + + L +EA L P QA +
Sbjct: 965 IESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRL 1024
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLE 1123
E+ W + + + ++ A +LQ+FL DLD F WL R Q A + +PN+L
Sbjct: 1025 AEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASED--MPNTLT 1082
Query: 1124 EADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHK 1183
EA+ LL +H +K E+D EEDY ++ E + G + L + L L+ GW++
Sbjct: 1083 EAEKLLTQHENIKNEIDNYEEDYQKMRDMGE--MVTQGQTDAQYMFLRQRLQALDTGWNE 1140
Query: 1184 LLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRD 1243
L +WE R+ L Q+H YQ FLRD +QA L NQE L+ E+P T+E E A+K+ D
Sbjct: 1141 LHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQED 1200
Query: 1244 FLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHD 1303
F+TTM+ +++K+ V+ L+ GNI ++ QE V + +++++N+ A + + +L D
Sbjct: 1201 FMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKD 1260
Query: 1304 QLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKI 1363
+LQ FL+DC EL WI+EKML A+D + ++ LH +WL+HQAFMAELA NKEWL+KI
Sbjct: 1261 NRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKI 1320
Query: 1364 EREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELD 1423
E+EG QL+ EKPE A V++KL + + W LESTTQ KA++LF+A+KA+ QS A+LD
Sbjct: 1321 EKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLD 1380
Query: 1424 KKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK 1483
K L +ESQ+Q D G DL +VN LKK Q +E+Q+E +E+ ELQ+Q AL E S
Sbjct: 1381 KWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKST 1440
Query: 1484 ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTER 1543
+ V ++ V + + LLEPL ER+ LLASKE+HQ D++DE+ WV ER+PLA T+
Sbjct: 1441 DEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDH 1500
Query: 1544 GNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA-GALASLRSPEAEAVRRGLEQLQSA 1602
G+ LQ VQ IKKNQ L++EIQ H PR++++ ER+ + S AEA+R+ L L+
Sbjct: 1501 GHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQL 1560
Query: 1603 WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 1662
W L E E+R + L+ A + +QYYFD AE EAW+ EQEL MMSE+K KDEQS + +LKK
Sbjct: 1561 WGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKK 1620
Query: 1663 HLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVA 1722
H LEQ VE+Y E++ QLS+ RAL+ HP+SE+IS RQS+VD+LY LK+L EERR
Sbjct: 1621 HQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGK 1680
Query: 1723 LEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE 1782
L++++ L+QL+R+V +LE WIAE+EVVAGS ELGQD+EHV++LQE+F EFA +TG G+E
Sbjct: 1681 LDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQE 1740
Query: 1783 RLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD 1842
R+ VN + DELI GH+ AAT+AEWKDGLNEAWA+LLEL+ TR Q+LAAS ELHKF+ D
Sbjct: 1741 RVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHD 1800
Query: 1843 ARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLR 1902
A+E+ G+I++K ++LP + + ++QR FEHD+Q L +QVRQLQE AA+L+
Sbjct: 1801 AKEIFGRIQDKHKKLPE--ELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQ 1858
Query: 1903 TVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIA 1962
YAG+ A+ I RE EVL+ WK LL ACE R+ + T D RF S VRDL+ WM+ +
Sbjct: 1859 AAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVI 1918
Query: 1963 SQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQ 2022
QI A +KPRDVSSVE+LMN HQG+K E++AR TTC ELG+SLL K ++EI+ +
Sbjct: 1919 RQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEK 1978
Query: 2023 LDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDE 2082
L +L +++E+ +KW+ WEWL+ +LEVHQF+++A VA+AWL QEP L SRE+G SVDE
Sbjct: 1979 LLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDE 2038
Query: 2083 VEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKA-------EQSKQPPTP 2127
VE+LI+RHEAF K+AA W+ERFS+L RLTT+E ++ E+ ++PP+P
Sbjct: 2039 VEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSP 2090
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 1966 bits (5092), Expect = 0.0
Identities = 1029/2124 (48%), Positives = 1421/2124 (66%), Gaps = 50/2124 (2%)
Query: 7 EVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQKKT 66
E +N+ P P + ARW++PD + + ++A LFE SRIKALADERE VQKKT
Sbjct: 6 EFENVGNQP-PYSRINARWDAPDDELDNDN-----SSARLFERSRIKALADEREVVQKKT 59
Query: 67 FTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKA 126
FTKWVNSHLARV C I DLY DLRDG +L +LLEVLSGE LP+PT+G+MRIH LENVDKA
Sbjct: 60 FTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKA 119
Query: 127 LQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDAL 186
LQFLKEQRVHLEN+GSHDIVDGNHRL LGL+WTIILRFQIQ I ++T++ RETRSAKDAL
Sbjct: 120 LQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDAL 179
Query: 187 LLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQRAFR 246
LLWCQMKTAGYP VN+ NFT+SW+DGLAFNALIH+HRPDL+DF KL SNA +NL+ AF
Sbjct: 180 LLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFN 239
Query: 247 TAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLE 306
AE+ LG+ LLDPEDV E PDEKSIITYVV+FYHYFSKMK LAVEGKR+GKV+D +E
Sbjct: 240 VAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIE 299
Query: 307 VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEK 366
K+IE+Y LA++LL WI +T+ +++++KFANSL+GVQQQLQAF+ Y T+EKP KFQEK
Sbjct: 300 TEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEK 359
Query: 367 GNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEK 426
GNLEVLLF+IQS++RA N++++ P +G + DI++AW LE+AE+ RE ALR ELIRQEK
Sbjct: 360 GNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEK 419
Query: 427 LELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQ 486
LE LA+RFD K AMRE+WL+ENQRLV+QDNFGY+L AVEAA KKHEAIE D AAYEERV+
Sbjct: 420 LEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVR 479
Query: 487 GVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVY 546
+ +LAQ L E Y+D +R+ A++D++LR W+ L L+ +RR RLE LALQK+FQ+M++
Sbjct: 480 ALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH 539
Query: 547 MVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQG 606
+DWM+E++A LLS E G+HL+E +DLLQKH L+E DIA Q ++V+A+ AA L+F++ +G
Sbjct: 540 SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKG 599
Query: 607 YQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERL 666
YQPCDPQVI +R++H+ C EL AA R+A+LE S+ LW E++EAESW ++KE++
Sbjct: 600 YQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQI 659
Query: 667 LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELV 726
+ G DL+S L +HK + EL G A L+Q + +V
Sbjct: 660 YSSLDYG---------------KDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
Query: 727 AAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLL 786
A P + R +W +L++ AA ++ LQ+A QF D D L
Sbjct: 705 ARKQFGHPQIEA--------RIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
Query: 787 DWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAG 846
WL+DA+RL + D G DE ++R L ++H+ E+E RG + L +Q
Sbjct: 757 AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDS 816
Query: 847 PLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906
P V R+ +L+ +V A LR+Q L++AL +Y +FGE ACELW+GEKE+WL
Sbjct: 817 PDVTH---RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAE 873
Query: 907 MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966
M +PD+L+D+EVVQHRF+ LDQEM +LM ++ VN LVE GHP S EV+ QDHLN
Sbjct: 874 MEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLN 933
Query: 967 SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG------AL 1020
+RW LV +R+E + + L V N+ ++ E + +K + VES G A+
Sbjct: 934 TRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAI 993
Query: 1021 QWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQAC 1080
Q +LSGLE + A++ R AL E+ L + P Q + Q + L W L + Q
Sbjct: 994 QRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQ 1053
Query: 1081 GEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVD 1140
+ + +LQ FL DLD F WL Q+A + +P SL EA+ LL +HA +K+E+D
Sbjct: 1054 EDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED--MPESLPEAEQLLQQHAGIKDEID 1111
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
++ Y R+ + E ++ G L L + L L+ GW+ L +WE+R L Q
Sbjct: 1112 GHQDSYQRVKESGEKVI--QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
+Q F +D +QA +L NQE L+ E P ++E+ E +++ DFL +ME ++ K+ V
Sbjct: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
Query: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGW 1320
+ L+ +GN+Y ++ +E V + +++++N +AQ+ L D LELQ+FL++C EL W
Sbjct: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
Query: 1321 IHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 1380
I++K+L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A
Sbjct: 1290 INDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTAL 1349
Query: 1381 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 1440
V +KL + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG
Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
Query: 1441 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 1500
DL +VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + L
Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDL 1463
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 1560
LEPL R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L
Sbjct: 1464 LEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTL 1523
Query: 1561 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 1620
+ EI H PR+E+VL+R L + + + L LQS+W LREAA R Q L A
Sbjct: 1524 QNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDA 1583
Query: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 1680
+ +QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL
Sbjct: 1584 NEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL 1643
Query: 1681 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740
+ + + LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE
Sbjct: 1644 ASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLE 1703
Query: 1741 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 1800
WI+EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+
Sbjct: 1704 QWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHS 1763
Query: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860
AAT+AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP
Sbjct: 1764 EAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE- 1822
Query: 1861 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 1920
+A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV
Sbjct: 1823 -DVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEV 1881
Query: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980
W+ LL AC R + TAD RF S RDLLSWM+ I QI ++PRDVSSVE+L
Sbjct: 1882 SAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELL 1941
Query: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
M YHQG+ E+E R + C ELG SLL + ++EI+ +L ++ +R++E++EKW+
Sbjct: 1942 MKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEAR 2001
Query: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
WE L+ +LEV QF+++A VA+AWL AQEP L S + G +VD VE+LI+RHEAF K+ A+W
Sbjct: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
Query: 2101 EERFSSLRRLTTIEKIKAEQSKQP 2124
ERF++L + TT+E + + +++P
Sbjct: 2062 AERFAALEKPTTLELKERQIAERP 2085
Score = 291 bits (746), Expect = 4e-78
Identities = 447/2167 (20%), Positives = 838/2167 (38%), Gaps = 259/2167 (11%)
Query: 493 QALAAEGYYDIRRVAAQRDSVLRQWALL---TGLVGARRTRLEQNLALQKVFQEMVYMVD 549
+ LA EG +RV D + ++ +GL T +EQ + + + +
Sbjct: 281 KVLAVEG----KRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTG 336
Query: 550 WMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQP 609
+++QA R VE Q+ G LE + R+ A N Y P
Sbjct: 337 VQQQLQAFSTYRT-----VEKPPKFQEKGNLEVLLFTIQSRMRANNQKV--------YTP 383
Query: 610 CDPQVICNRVNHVHGCLAELQEQAARR----RAELEASRSLWALLQELEEA----ESWAR 661
D ++ V+ ++ L+E RR R EL L L + + E+W
Sbjct: 384 HDGKL----VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLS 439
Query: 662 DKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRC 721
+ +RL+ G +DL++ +H+ ++ + A ++ +R
Sbjct: 440 ENQRLVAQDNFG---------------YDLAAVEAAKKKHEAIETDT----AAYEERVRA 480
Query: 722 GEELVAAGGAVGPGADTVH-LVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGA 780
E+L A + H + R + R W L+E R +RL+ AL +
Sbjct: 481 LEDL-----AQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
Query: 781 DLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLG 840
D+ +DW+ + + +FG L ++H+ + ++ V + ATL
Sbjct: 536 DMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITA--ATLK 593
Query: 841 GASGAG-----PLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
G G P V+ Q R+ EQ F E++ +AA R+ L + +++ F E+ E
Sbjct: 594 FTEGKGYQPCDPQVI--QDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAES 651
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSL---MGRVLDVNHTVQELVEGGH 952
WI EKEQ S+ L V ++Q + ++ + E+ L + ++ H + + GH
Sbjct: 652 WIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGH 711
Query: 953 PSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAV-- 1010
P ++ + ++++W+++ +L K+ + + +++A +++ R +
Sbjct: 712 P---QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
Query: 1011 ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQ------AARLHQGAE 1064
E + GA + + L+ LE + ++E A+ FP + Q
Sbjct: 769 EDVGQDEGATRALGKKHKDFLEELEESRG-VMEHLEQQAQGFPEEFRDSPDVTHRLQALR 827
Query: 1065 ELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEE 1124
EL + A A Q + + A L + DA W+ ++ E +P++LE+
Sbjct: 828 ELYQQVVAQADLRQ---QRLQEALDLYTVFGETDACELWMGEKEKWLAEME--MPDTLED 882
Query: 1125 ADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKL 1184
+ + R L +E+ + A+ +L+ + + ++ HL W
Sbjct: 883 LEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPR---SREVKQYQDHLNTRWQAF 939
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALS-----GAELPGTVESVEEALK 1239
L RREA+ A + D + + ++ + G +L G + +
Sbjct: 940 QTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK--- 996
Query: 1240 QHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQ 1299
L+ +E +Q V A E +Q + +E + + + +E QQ +Q
Sbjct: 997 -----LSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQ 1051
Query: 1300 KLHDQL----ELQHFLRDCHELDGWIH-EKMLMARDGTREDNHKLHKRWLRHQAFMAELA 1354
D L +LQ FL+D + W+ + +A + E + + +H E+
Sbjct: 1052 GQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEID 1111
Query: 1355 QNKEWLEKIEREGQQLMQEK--PELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKA 1412
+++ ++++ G++++Q + PE + ++L + W L ++++ L +
Sbjct: 1112 GHQDSYQRVKESGEKVIQGQTDPEYLL-LGQRLEGLDTGWNALGRMWESRSHTLAQCLGF 1170
Query: 1413 DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-GELQA 1471
+ + + + L + E L ++P L + ++K + +E +V + +
Sbjct: 1171 QEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDS 1230
Query: 1472 QTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWV 1531
+ + + E+ + +R + E QE LL + EL + + W+
Sbjct: 1231 GNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWI 1290
Query: 1532 QERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEA 1591
++L L Q + + + K+Q E+ +H LE + L +
Sbjct: 1291 NDKL-LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTAL 1349
Query: 1592 VRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGK 1651
V + LE L W L+ + + Q L AA + A++ W+ E + S+D GK
Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
Query: 1652 DEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVA 1711
D S ++L K ++E V +E + +L Q ++ E G I +R ++
Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKR-------FLD 1462
Query: 1712 LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSE 1771
L E R+ LE Q+SR + + W+ E+ +A S + G + + V + +K
Sbjct: 1463 LLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQT 1522
Query: 1772 FASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLA 1831
+E + R+ V Q +L+E + E L +W L E R Q L
Sbjct: 1523 LQNEI-LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLR 1581
Query: 1832 ASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQV 1891
+ E +++ DA E + I E+ + P + + ++R LR + ++ +
Sbjct: 1582 DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQ-QRAVEDYGRNI 1640
Query: 1892 RQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQV 1951
+QL A L + E E I + +V + + L E+ + + + + +
Sbjct: 1641 KQLASRAQGLLSAGHPE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRET 1699
Query: 1952 RDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLN 2011
DL W+ + + +D V +L + + E A +G+ + N
Sbjct: 1700 DDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGA----------IGQERVDN 1749
Query: 2012 KSAMADEI----QAQLDKLGTRKEEVSEKW-------DRHWEWLQQMLEVHQFAQEAVVA 2060
+A + + ++ + K+ ++E W D + L ++H++
Sbjct: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
Query: 2061 DAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKA-------AAAWEERFSSLRRLTTI 2113
+ + L ++G E R H AF + +++ + L+
Sbjct: 1810 LGLIDEKHRELPE-DVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAG 1868
Query: 2114 EKIKAEQSKQPPTPLL---------GRK-----------FFGDPTELAAKAAPLLRP--- 2150
EK +A Q+K+ GR+ FF +L + ++R
Sbjct: 1869 EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIET 1928
Query: 2151 -------------GGYERGLEPLARRASDTLSA------EVRTRVGYVRQELKPERLQPR 2191
Y +G+ S SA + R +E++ E+LQ
Sbjct: 1929 QERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR-EKLQQV 1987
Query: 2192 IDRLPEIPGRVEPA--------ALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL 2243
+ R E+ + E + DA+ A A E + + D E+L
Sbjct: 1988 MSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKL 2047
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+R + + +E A +P E E + A ER E
Sbjct: 2048 IKRHEAFEKSTASWAERFAALEKPTTLELKERQIA------------------ERPAEET 2089
Query: 2304 ESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP---SLPQPRELPPGRLPNGL 2360
E+E G+ A + + PG G +L QP PPG+ +G
Sbjct: 2090 GPQEEEGETAGE--------APVSHHAATERTSPGEEEGTWPQNLQQPP--PPGQHKDG- 2138
Query: 2361 ELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPT---H 2417
+++ +RP K P G PA P P
Sbjct: 2139 ---QKSTGDERPTTEPLFKVL------------------DTPLSEGDEPATLPAPRDHGQ 2177
Query: 2418 TVQHEGFLLRKRELDA-NRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGSTHGGEPLLS 2476
+VQ EG+L RK +L+ N+K+SNRSW +LYCVL EL FYKD+K A G + GE L+
Sbjct: 2178 SVQMEGYLGRKHDLEGPNKKASNRSWNNLYCVLRNSELTFYKDAKNLALGMPYHGEEPLA 2237
Query: 2477 LHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVASSVAEHAEIARWG 2536
L A E+A++YKKKKHVFKL+ +GSE+L KDEEEM WL+ V++++ E I
Sbjct: 2238 LRHAICEIAANYKKKKHVFKLRLSNGSEWLFHGKDEEEMLSWLQGVSTAINESQSIRVKA 2297
Query: 2537 QTLPTTS 2543
Q+LP S
Sbjct: 2298 QSLPLPS 2304
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 1966 bits (5092), Expect = 0.0
Identities = 1029/2124 (48%), Positives = 1421/2124 (66%), Gaps = 50/2124 (2%)
Query: 7 EVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQKKT 66
E +N+ P P + ARW++PD + + ++A LFE SRIKALADERE VQKKT
Sbjct: 6 EFENVGNQP-PYSRINARWDAPDDELDNDN-----SSARLFERSRIKALADEREVVQKKT 59
Query: 67 FTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKA 126
FTKWVNSHLARV C I DLY DLRDG +L +LLEVLSGE LP+PT+G+MRIH LENVDKA
Sbjct: 60 FTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKA 119
Query: 127 LQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDAL 186
LQFLKEQRVHLEN+GSHDIVDGNHRL LGL+WTIILRFQIQ I ++T++ RETRSAKDAL
Sbjct: 120 LQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDAL 179
Query: 187 LLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQRAFR 246
LLWCQMKTAGYP VN+ NFT+SW+DGLAFNALIH+HRPDL+DF KL SNA +NL+ AF
Sbjct: 180 LLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFN 239
Query: 247 TAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLE 306
AE+ LG+ LLDPEDV E PDEKSIITYVV+FYHYFSKMK LAVEGKR+GKV+D +E
Sbjct: 240 VAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIE 299
Query: 307 VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEK 366
K+IE+Y LA++LL WI +T+ +++++KFANSL+GVQQQLQAF+ Y T+EKP KFQEK
Sbjct: 300 TEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEK 359
Query: 367 GNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEK 426
GNLEVLLF+IQS++RA N++++ P +G + DI++AW LE+AE+ RE ALR ELIRQEK
Sbjct: 360 GNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEK 419
Query: 427 LELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQ 486
LE LA+RFD K AMRE+WL+ENQRLV+QDNFGY+L AVEAA KKHEAIE D AAYEERV+
Sbjct: 420 LEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVR 479
Query: 487 GVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVY 546
+ +LAQ L E Y+D +R+ A++D++LR W+ L L+ +RR RLE LALQK+FQ+M++
Sbjct: 480 ALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH 539
Query: 547 MVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQG 606
+DWM+E++A LLS E G+HL+E +DLLQKH L+E DIA Q ++V+A+ AA L+F++ +G
Sbjct: 540 SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKG 599
Query: 607 YQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERL 666
YQPCDPQVI +R++H+ C EL AA R+A+LE S+ LW E++EAESW ++KE++
Sbjct: 600 YQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQI 659
Query: 667 LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELV 726
+ G DL+S L +HK + EL G A L+Q + +V
Sbjct: 660 YSSLDYG---------------KDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
Query: 727 AAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLL 786
A P + R +W +L++ AA ++ LQ+A QF D D L
Sbjct: 705 ARKQFGHPQIEA--------RIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
Query: 787 DWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAG 846
WL+DA+RL + D G DE ++R L ++H+ E+E RG + L +Q
Sbjct: 757 AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDS 816
Query: 847 PLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906
P V R+ +L+ +V A LR+Q L++AL +Y +FGE ACELW+GEKE+WL
Sbjct: 817 PDVTH---RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAE 873
Query: 907 MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966
M +PD+L+D+EVVQHRF+ LDQEM +LM ++ VN LVE GHP S EV+ QDHLN
Sbjct: 874 MEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLN 933
Query: 967 SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG------AL 1020
+RW LV +R+E + + L V N+ ++ E + +K + VES G A+
Sbjct: 934 TRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAI 993
Query: 1021 QWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQAC 1080
Q +LSGLE + A++ R AL E+ L + P Q + Q + L W L + Q
Sbjct: 994 QRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQ 1053
Query: 1081 GEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVD 1140
+ + +LQ FL DLD F WL Q+A + +P SL EA+ LL +HA +K+E+D
Sbjct: 1054 EDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED--MPESLPEAEQLLQQHAGIKDEID 1111
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
++ Y R+ + E ++ G L L + L L+ GW+ L +WE+R L Q
Sbjct: 1112 GHQDSYQRVKESGEKVI--QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
+Q F +D +QA +L NQE L+ E P ++E+ E +++ DFL +ME ++ K+ V
Sbjct: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
Query: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGW 1320
+ L+ +GN+Y ++ +E V + +++++N +AQ+ L D LELQ+FL++C EL W
Sbjct: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
Query: 1321 IHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 1380
I++K+L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A
Sbjct: 1290 INDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTAL 1349
Query: 1381 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 1440
V +KL + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG
Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
Query: 1441 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 1500
DL +VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + L
Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDL 1463
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 1560
LEPL R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L
Sbjct: 1464 LEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTL 1523
Query: 1561 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 1620
+ EI H PR+E+VL+R L + + + L LQS+W LREAA R Q L A
Sbjct: 1524 QNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDA 1583
Query: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 1680
+ +QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL
Sbjct: 1584 NEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL 1643
Query: 1681 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740
+ + + LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE
Sbjct: 1644 ASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLE 1703
Query: 1741 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 1800
WI+EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+
Sbjct: 1704 QWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHS 1763
Query: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860
AAT+AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP
Sbjct: 1764 EAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE- 1822
Query: 1861 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 1920
+A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV
Sbjct: 1823 -DVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEV 1881
Query: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980
W+ LL AC R + TAD RF S RDLLSWM+ I QI ++PRDVSSVE+L
Sbjct: 1882 SAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELL 1941
Query: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
M YHQG+ E+E R + C ELG SLL + ++EI+ +L ++ +R++E++EKW+
Sbjct: 1942 MKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEAR 2001
Query: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
WE L+ +LEV QF+++A VA+AWL AQEP L S + G +VD VE+LI+RHEAF K+ A+W
Sbjct: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
Query: 2101 EERFSSLRRLTTIEKIKAEQSKQP 2124
ERF++L + TT+E + + +++P
Sbjct: 2062 AERFAALEKPTTLELKERQIAERP 2085
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 1962 bits (5082), Expect = 0.0
Identities = 1093/2290 (47%), Positives = 1477/2290 (64%), Gaps = 112/2290 (4%)
Query: 5 PGEVDNME--GLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAV 62
P + D++E G + NN RW+ PD W+ + +++A LFE SRIKALADEREAV
Sbjct: 7 PTDFDSLEIQGQYSDINN---RWDLPDSDWDND-----SSSARLFERSRIKALADEREAV 58
Query: 63 QKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLEN 122
QKKTFTKWVNSHLARV C +GDLY DLRDG L RLLEVLSGE LP+PT+GRMRIH LEN
Sbjct: 59 QKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLEN 118
Query: 123 VDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSA 182
VDKALQFLKEQ+VHLEN+GSHDIVDGNHRLTLGLVWTIILRFQIQ I +ETEDN+E +SA
Sbjct: 119 VDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSA 178
Query: 183 KDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQ 242
KDALLLWCQMKTAGYP VN+ NFTTSWRDGLAFNA++H+HRPDL+DF L K NA+YNLQ
Sbjct: 179 KDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQ 238
Query: 243 RAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLD 302
AF AE+ LGL +LLDPEDVN++ PDEKSIITYV ++YHYFSKMKALAVEGKRIGKVLD
Sbjct: 239 NAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLD 298
Query: 303 QVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVK 362
+E +++E+YE LA+ELL WI +T+ +++++ ANSLSGVQ QLQ+F +Y T+EKP K
Sbjct: 299 HAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPK 358
Query: 363 FQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELI 422
F EKGNLEVLLF+IQSKLRA N++++ PREG I DI+KAW LEKAEHERE ALR ELI
Sbjct: 359 FTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELI 418
Query: 423 RQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYE 482
RQEKLE LA RFD K AMRE+WL+ENQRLVSQDNFG EL AVEAA++KHEAIE DI AY
Sbjct: 419 RQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYS 478
Query: 483 ERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQ 542
RVQ V +A LAAE Y+DI+R+AA++ +V R W L +V ARR RL NL LQKVFQ
Sbjct: 479 GRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQ 538
Query: 543 EMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRF- 601
+++Y++DWMEEM+ +L S++ G+HL +DLLQ H L+E DIA Q+ERV A++A+ALRF
Sbjct: 539 DLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFC 598
Query: 602 SQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWAR 661
+ + Y+PCDPQ++ RV + L E AA RRA LE SR LW L E+ EAE+W R
Sbjct: 599 NPGKEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVR 658
Query: 662 DKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRC 721
+++ LL +A G DL+ RLL +H L+GE+ GR L+ L
Sbjct: 659 EQQHLLASADTG---------------RDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQ 703
Query: 722 GEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGAD 781
G++LVA G PGA + RAA + +W+RLE A R +RL +A +L+QF AD
Sbjct: 704 GQQLVAEG---HPGASQA-----SARAAELQAQWERLEALAEERAQRLAQAASLYQFQAD 755
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
+ + WL DA RL ++ + GHDE S++ LARQHRAL E+ +HR + LR Q A L
Sbjct: 756 ANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPP 815
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
P V Q RV E+ + E+ A R + L ALA+Y M E AC LW+ EKE
Sbjct: 816 TLSRTPEV---QGRVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKE 872
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
QWL + +P+ L+D+EVVQ RFE+L+ EMN+L ++ VN ++L++ P D + +
Sbjct: 873 QWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNT 932
Query: 962 QDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG--- 1018
Q+ LN RW + L + +K +++ L ++N+ LE E +A +REK + +ES G
Sbjct: 933 QEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLA 992
Query: 1019 ---ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALAS 1075
ALQ +L+G E L+A+ R L EA LA PAQA ++ E+ W L +
Sbjct: 993 GVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRA 1052
Query: 1076 AAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAAL 1135
+ E++ A RLQ FL LD F WL R Q A EGP +L EA+ALLA+HAAL
Sbjct: 1053 TMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPA--TLPEAEALLAQHAAL 1110
Query: 1136 KEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREAL 1195
+ EV++ + +Y+R+ A E + D A+ L L + L L GW +L +WE+R+ L
Sbjct: 1111 RGEVERAQSEYSRLRALGEE-VTRDQAD-PQCLFLRQRLEALGTGWEELGRMWESRQGRL 1168
Query: 1196 VQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKM 1255
QAH +Q FLRD RQA VL +QE LS E+PGT+++ + A+K+ DF++TM+ + +++
Sbjct: 1169 AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERI 1228
Query: 1256 QVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCH 1315
++A L+ +GNI+ ++ +E + ++++NQ AQQ++ +L D E QHFL+DCH
Sbjct: 1229 HGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCH 1288
Query: 1316 ELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP 1375
EL WI EKML A+D + ++ LH +W +HQAFMAELA NK+WL+K+++EG++L EKP
Sbjct: 1289 ELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKP 1348
Query: 1376 ELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQD 1435
EL A V +KL ++ + W ELE+TTQAKAR LF+A++A+ QS L+ L +++QL
Sbjct: 1349 ELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS 1408
Query: 1436 VDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGE 1495
D G DL +VN LKK Q +E ++ +EV +QAQ AL E V AV E
Sbjct: 1409 DDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEE 1468
Query: 1496 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 1555
+ L +P++ER R L AS+E HQ D++DE+ WV ERLP+A E G L +VQ +K
Sbjct: 1469 KFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMK 1528
Query: 1556 KNQGLRREIQAHGPRLEEVLERAGAL-ASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQ 1614
KNQ L++EIQ H PR+ ++ ER AL A+ PE L +LQ W L E R
Sbjct: 1529 KNQTLQKEIQGHEPRIADLRERQRALGAAAAGPE-------LAELQEMWKRLGHELELRG 1581
Query: 1615 QVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYE 1674
+ L+ A + +Q+Y D AE EAW+GEQEL MM ++K KDE S +KKH LEQ + +Y
Sbjct: 1582 KRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYA 1641
Query: 1675 ESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSR 1734
++I QL+ + +++ HP+S +IS RQ+QVD+LY LKEL ERR L++ L QL R
Sbjct: 1642 QTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRR 1701
Query: 1735 QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL 1794
++ +LE WI E+EVVA S ELGQD+EHV++L++KF EF+ +T G+ER+ + N + + L
Sbjct: 1702 ELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGL 1761
Query: 1795 IECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKR 1854
I GH A AT+AEWKD LNEAWA+LLEL+ TR Q+LAA+ EL +F AR+ +++ K+
Sbjct: 1762 IAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQ 1821
Query: 1855 RRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIA 1914
++LP T +A ++QR A+EHD+Q L QV+Q+Q+ +L+ YAG+ AE I
Sbjct: 1822 QQLPDGT--GRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIG 1879
Query: 1915 SREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDV 1974
Q V + W +L + R + T D RF VR+L+ WMD + Q+ A ++PRDV
Sbjct: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDV 1939
Query: 1975 SSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVS 2034
SS ++++ QG+K E+EAR ++C ++G+ LL A+EI +L +L R++E +
Sbjct: 1940 SSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARRQETA 1999
Query: 2035 EKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094
EKW +WLQ +LEV F ++A +A+AWL +QEPL++S ELG +VDEVE LI+RHEAF+
Sbjct: 2000 EKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQ 2059
Query: 2095 KAAAAWEERFSSLRRLTTIE---------KIKAEQSKQPPTPLLGRKFFGDPTELAAKAA 2145
K+A AWEERF +L +LT +E + + E+ KQPP P +PT A
Sbjct: 2060 KSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAP--------EPT---ASVP 2108
Query: 2146 PLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRI-----DRLPEIP- 2199
P GG + ASDT + R P P + D P P
Sbjct: 2109 PGDLVGG---------QTASDTTWDGTQPRP-------PPSTQAPSVNGVCTDGEPSQPL 2152
Query: 2200 ---GRVEPAALPAAP----EDAAETP------ATPAAAEQVRPRPERQESADRAEELPRR 2246
R+E ++ P P D A P T A P+ ESA A PR
Sbjct: 2153 LGQQRLEHSSFPEGPGPGSGDEANGPRGERQTRTRGPAPSAMPQSRSTESAHAATLPPRG 2212
Query: 2247 RRPERQESVD 2256
P QE ++
Sbjct: 2213 PEPSAQEQME 2222
Score = 361 bits (926), Expect = 6e-99
Identities = 487/2091 (23%), Positives = 833/2091 (39%), Gaps = 208/2091 (9%)
Query: 515 RQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLL 574
R+ AL T L+ R+ +LEQ A + ++ W+ E Q + G L + +
Sbjct: 409 RELALRTELI--RQEKLEQLAA--RFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAV 464
Query: 575 QKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAA 634
+KH +E DI A S RV+A++A A ++L + D + I R ++V L++ A
Sbjct: 465 RKHEAIETDIVAYSGRVQAVDAVA---AELAAERYHDIKRIAARQHNVARLWDFLRQMVA 521
Query: 635 RRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
RR L + L + Q+L W + + L++ G L+
Sbjct: 522 ARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLG---------------RHLAGV 566
Query: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
LL H++++ ++ + ++ G P + ++ER A +
Sbjct: 567 EDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQL----VSERVAKLEQS 622
Query: 755 WQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQ 814
++ L E AA R RL+E+R L +F ++ W+R+ L A+ D G D + RL +
Sbjct: 623 YEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNK 682
Query: 815 HRALTGEVEAHRGPVS---GLRRQLATLG--GASGAGPLVVALQVRVVEAEQLFAEVTEV 869
H AL GE+ GP+ +QL G GAS A LQ + E L E
Sbjct: 683 HTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEE---- 738
Query: 870 AALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQE 929
R Q L A ++Y+ + + E W+ + + + S + + + + +L++E
Sbjct: 739 ---RAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795
Query: 930 MNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLV 989
+ S LD + + EV+ L + + +R + A L +
Sbjct: 796 IRSHRP-TLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALAL 854
Query: 990 ENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQ---ALEPRQAALLEE-- 1044
+ E V EK + + G AL RL LE Q LEP L +
Sbjct: 855 YTMLSEAGACGLWVEEKEQWLN-----GLALPERLEDLEVVQQRFETLEPEMNTLAAQIT 909
Query: 1045 -----AALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
A L + P R+ E+L W A A+ +A +Q + +
Sbjct: 910 AVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTE 969
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAA 1159
W+ + ++G L N L AL + A + +++ + + AL A
Sbjct: 970 TQAWMREKTKVIESTQG-LGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAG 1028
Query: 1160 DGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQE 1219
A+ +A++ L ++ GW L R E+L +A Q FLR L L +
Sbjct: 1029 HPAQ---AVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
Query: 1220 MALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGN----IYGEQ 1275
A++ E P T+ E L QH +E +Q + E + R ++ Q
Sbjct: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
Query: 1276 AQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARD----G 1331
EA+ E+ Q + + H Q FLRD + +G + + + G
Sbjct: 1146 RLEALGTGWEELGRMWESRQGRLAQAHG---FQGFLRDARQAEGVLSSQEYVLSHTEMPG 1202
Query: 1332 TREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQC 1391
T + K+ + FM+ + N E + + G+QL+ E A +R+K I +
Sbjct: 1203 TLQAADAAIKKL---EDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERR 1259
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLA-TVNSQLK 1450
+ + Q +L + + +Q EL KL E L D D A ++++ +
Sbjct: 1260 HKKNQDAAQQFLGRLRDNREQQHFLQDCHEL--KLWIDEKMLTAQDVSYDEARNLHTKWQ 1317
Query: 1451 KLQSMESQVEEWYREVGELQAQTAALPLE-PASKELVGERQNAVGERLVRLLEPLQERRR 1509
K Q+ +++ + ++ + L LE P K LV E+ + R L Q + R
Sbjct: 1318 KHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKAR 1377
Query: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569
L + A +W++ + G L +V +KK Q L E+
Sbjct: 1378 SLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREK 1437
Query: 1570 RLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFD 1629
+E + +A ALA A V R ++ + L + R + L A+ + Q++ D
Sbjct: 1438 EVEAIQAQAKALAQ-EDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRD 1496
Query: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 1689
V + W+ E+ + S + GKD S L+KK+ L++ ++ +E IA L + RAL
Sbjct: 1497 VEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGA 1556
Query: 1690 MGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+++ Q RL L+ G+ AL Q Q R +E E W+ E+E+
Sbjct: 1557 AAA--GPELAELQEMWKRLGHELELRGKRLEDALRAQ----QFYRDAAEAEAWMGEQELH 1610
Query: 1750 AGSPELGQD-------FEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
E +D + VL++ +++A +LAA +Q ++I+ H +
Sbjct: 1611 MMGQEKAKDELSAQAEVKKHQVLEQALADYAQTI-----HQLAASSQ---DMIDHEHPES 1662
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 1862
++ + +++ +A L EL G R + L L + + +L+ I+E R +
Sbjct: 1663 TRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQE-REVVAASHE 1721
Query: 1863 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAE--AIASREQEV 1920
+ + ++ R F D + + ++ A + AG HA +A + +
Sbjct: 1722 LGQDYEHVTMLRDKFREFSRDTSTIGQE--RVDSANALANGLIAGGHAARATVAEWKDSL 1779
Query: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980
+ W +LL + +++ + RF R L+ + Q+ RD+++ E L
Sbjct: 1780 NEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTG-RDLNAAEAL 1838
Query: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
H + +++A P++ Q+ G L Q G + EE+ RH
Sbjct: 1839 QRRHCAYEHDIQALSPQVQQVQDDGHRL-------------QKAYAGDKAEEIG----RH 1881
Query: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
+ VA+AW Q GSS + L+ + FR
Sbjct: 1882 MQ---------------AVAEAWAQLQ---------GSSAARRQLLLDTTDKFRF----- 1912
Query: 2101 EERFSSLRRLTT-IEKIKAEQSKQP------PTPLLGRKFFGDPTELAAKAAPLLRPGGY 2153
F ++R L ++++ + Q L+ + G E+ A+A
Sbjct: 1913 ---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRF--SSCI 1967
Query: 2154 ERGLEPLARRASDTLSAEVRTRVGYV--RQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211
+ G E LAR S + E+ ++ + R++ E+ Q ++D L + +
Sbjct: 1968 DMGKELLAR--SHYAAEEISEKLSQLQARRQETAEKWQEKMDWLQLV------LEVLVFG 2019
Query: 2212 EDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQE 2271
DA A + E + E + D E L +R ++ +V E + E
Sbjct: 2020 RDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALE 2079
Query: 2272 SAEHEAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQ 2331
E E +R+RE ERR + GDLV G+ T +D
Sbjct: 2080 EREKER------------KRKREEEERRKQPPAPEPTASVPPGDLVGGQ-TASDTTWDGT 2126
Query: 2332 EKEAGP-------------GLPAGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRP 2378
+ P G P+ P L Q R L P G P P + P
Sbjct: 2127 QPRPPPSTQAPSVNGVCTDGEPSQPLLGQQR-LEHSSFPEG-------PGPGSGDEANGP 2178
Query: 2379 KPRRRPRPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKRELDA-NRKS 2437
+ R+ R R + + A + P P P+ Q EG L RK+E++A +K+
Sbjct: 2179 RGERQTRTRGPAPSAMPQSRSTESAHAATLPPRGPEPSAQEQMEGMLCRKQEMEAFGKKA 2238
Query: 2438 SNRSWVSLYCVLSKGELGFYKDSKGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKL 2497
+NRSW ++YCVL +G LGFYKD+K ++G + GE +SL +A VA DY+K+KHVFKL
Sbjct: 2239 ANRSWQNVYCVLRRGSLGFYKDAKAASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKL 2298
Query: 2498 QTQDGSEFLLQAKDEEEMNGWLEAVASSVAEHAEIARWGQTLPTTSSTDEG 2548
QDG E+L QAKDE EM+ WL V +++A A A P ST G
Sbjct: 2299 GLQDGKEYLFQAKDEAEMSSWLRVVNAAIAT-ASSASGEPEEPVVPSTTRG 2348
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
sapiens]
Length = 678
Score = 1265 bits (3273), Expect = 0.0
Identities = 650/653 (99%), Positives = 651/653 (99%)
Query: 1325 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 1384
MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK
Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
Query: 1385 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 1444
LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT
Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
Query: 1445 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 1504
VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL
Sbjct: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
Query: 1505 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 1564
QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI
Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
Query: 1565 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 1624
QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE
Sbjct: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
Query: 1625 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 1684
QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC
Sbjct: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
Query: 1685 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 1744
RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA
Sbjct: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
Query: 1745 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 1804
EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT
Sbjct: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP
Sbjct: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 1924
EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW
Sbjct: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
Query: 1925 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSV 1977
KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPR SS+
Sbjct: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
Score = 149 bits (376), Expect = 3e-35
Identities = 164/667 (24%), Positives = 274/667 (41%), Gaps = 48/667 (7%)
Query: 470 KHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRT 529
+H+A A++A +E ++ + Q L E V + + + WA L A+
Sbjct: 21 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 80
Query: 530 RLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE 589
+L + ++ Q + + M++QL + G L + L+K +E +
Sbjct: 81 QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYR 140
Query: 590 RVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649
V L A +P +++ R N V L L E RR L AS+ L +
Sbjct: 141 EVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 196
Query: 650 LQELEEAESWARDKERL-LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGEL 708
+L++ +W +++ L ++ G G L A + ++
Sbjct: 197 AHDLDDELAWVQERLPLAMQTERGNG----------------------LQAVQQHIKKNQ 234
Query: 709 GGRRALLQQALRCGEELVAAGGAVG---PGADTVHLVGLAERAASARRRWQRLEEAAARR 765
G RR + R E L AG P A+ V GL E+ SA W L EAA RR
Sbjct: 235 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR-GL-EQLQSA---WAGLREAAERR 289
Query: 766 ERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAH 825
++ L A + Q+ D+ + WL + L + D G DE S+ +L ++H L VE +
Sbjct: 290 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 349
Query: 826 RGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYR 885
++ L RQ L P + R + ++L+ + E+ RR L +Y+
Sbjct: 350 EESIAQLSRQCRAL--LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQ 407
Query: 886 MFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSL-MGRVLDVNHTV 944
+ +V E WI EKE S + + V V+Q +F E R+ VN V
Sbjct: 408 LSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMV 467
Query: 945 QELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVR 1004
EL+E GH ++ + +D LN W ++EL+ R + ++A + + E++ Q+
Sbjct: 468 DELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIE 527
Query: 1005 EKRRAV-------ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQ-A 1056
EKRR + E P A ++Q L E LQ L + L E AA L + + A
Sbjct: 528 EKRRRLPRLTTPPEPRPSA-SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA 586
Query: 1057 ARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEG 1116
+ +E+ W L SA + V++ RF + L W+ G ++
Sbjct: 587 EAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADK 646
Query: 1117 P-LPNSL 1122
P P+SL
Sbjct: 647 PRCPSSL 653
Score = 84.0 bits (206), Expect = 2e-15
Identities = 96/395 (24%), Positives = 163/395 (41%), Gaps = 52/395 (13%)
Query: 294 GKRIGKVLDQVLEVGKIIERYEEL---AAEL---LAWIHRTVGLISNQKFANSLSGVQQQ 347
G+R+ ++L+ + E +++ +EL A +L LAW+ + L + N L VQQ
Sbjct: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
Query: 348 LQAFTAYCTLEKPVKFQEKGNLEVL-----LFSIQSKLRACNRRLFVPREGCGIWDIDKA 402
++ L + ++ EVL L S++S RR G+ + A
Sbjct: 230 IKKNQG---LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRR--------GLEQLQSA 278
Query: 403 WGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELP 462
W L REAA R + + ++ FD VA E+WL E + L+ ++ G +
Sbjct: 279 WAGL------REAAERRQQVLDAAFQVEQYYFD--VAEVEAWLGEQELLMMSEDKGKDEQ 330
Query: 463 AVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTG 522
+ +KKH +E + YEE + ++ +AL G+ D +++ ++ V R + L
Sbjct: 331 STLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKE 390
Query: 523 LVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEG 582
L RR LEQ L ++ +++ + W+ E + S E GQ L +K
Sbjct: 391 LGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS 450
Query: 583 DIA-AQSERVEALNAAALRFSQLQGYQPCDPQVICNRV---------NHVHGCLAELQEQ 632
+ A ER+ A+N Q D + C + ++ AEL E
Sbjct: 451 ETGMAGRERLAAVN------------QMVDELIECGHTAAATMAEWKDGLNEAWAELLEL 498
Query: 633 AARRRAELEASRSLWALLQELEEAESWARDKERLL 667
R L ASR L + E + +K R L
Sbjct: 499 MGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533
Score = 78.6 bits (192), Expect = 8e-14
Identities = 67/329 (20%), Positives = 143/329 (43%), Gaps = 3/329 (0%)
Query: 1781 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 1840
+E L + + +L++ AA++ + + + WAEL +A+ L + + +
Sbjct: 33 KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLV 92
Query: 1841 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 1900
EL ++ +L + P + +S + L++ E ++ +V +LQ A
Sbjct: 93 QSFAELDKKLLHMESQLQDVD-PGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 151
Query: 1901 LRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDG 1960
L A + E + R+ V + LL ++ R + ++ + + + D L+W+
Sbjct: 152 LPLEPASK--ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE 209
Query: 1961 IASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ 2020
++ + +V+ + +QGL+ E++A P L E +L +S A+ ++
Sbjct: 210 RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR 269
Query: 2021 AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSV 2080
L++L + + E +R + L +V Q+ + +AWL QE L+ S + G
Sbjct: 270 RGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE 329
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRR 2109
QL+++H + +EE + L R
Sbjct: 330 QSTLQLLKKHLQLEQGVENYEESIAQLSR 358
Score = 75.1 bits (183), Expect = 8e-13
Identities = 90/476 (18%), Positives = 201/476 (42%), Gaps = 17/476 (3%)
Query: 1642 LLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRR 1701
+LM + +D + +H + +E + ++ R+ + L++ + + ++
Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
Query: 1702 QSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEH 1761
++ + + L+ + + L + QL + +EL+ + E + G D
Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
Query: 1762 VSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLE 1821
V+ +K S+ RE Q + + + E ++ + E LLE
Sbjct: 121 VNSQLKKLQSMESQVEEWYRE--VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLE 178
Query: 1822 LMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR--- 1878
+ R +LL AS+ELH+ A +L ++ + RLP L E ++Q+ ++
Sbjct: 179 PLQERRRLLLASKELHQV---AHDLDDELAWVQERLP-LAMQTERGNGLQAVQQHIKKNQ 234
Query: 1879 AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHV 1938
++Q ++ ++ E A L ++ + E AEA+ +++ W L A E + +
Sbjct: 235 GLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVL 293
Query: 1939 SSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPEL 1998
+ +++ V ++ +W+ + + DK +D S L+ H L+ +E +
Sbjct: 294 DAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI 353
Query: 1999 TTCQELGRSLLLNKSAMADEI---QAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQ 2055
R+LL +++I Q+Q+D+L +E+ E+ L+Q ++Q ++
Sbjct: 354 AQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE---RRVALEQQYWLYQLSR 410
Query: 2056 EAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF-RKAAAAWEERFSSLRRL 2110
+ + W+ +E + S ELG + V L + F + A ER +++ ++
Sbjct: 411 QVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQM 466
Score = 72.8 bits (177), Expect = 4e-12
Identities = 120/631 (19%), Positives = 261/631 (41%), Gaps = 31/631 (4%)
Query: 1044 EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDW 1103
E L + P AA + + E+ W L S QA + A + + + A LD
Sbjct: 42 EGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSF-AELDK 100
Query: 1104 LVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAE 1163
+ E+ P L ++ L + +++ +V++ + + A + AL ++
Sbjct: 101 KLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK 159
Query: 1164 LGPGL---ALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEM 1220
G A+ E L L L L E RR L ++Q+ DL L ++ +
Sbjct: 160 ELVGERQNAVGERLVRL------LEPLQERRRLLLASKELHQV-AHDLDDELAWVQERLP 212
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAV 1280
E +++V++ +K+++ ++ +++ ++ A L ++ +A EAV
Sbjct: 213 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL---ASLRSPEA-EAV 268
Query: 1281 TRLLEKNQEN----QLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEK-MLMARDGTRED 1335
R LE+ Q + A++ Q L +++ + D E++ W+ E+ +LM + +D
Sbjct: 269 RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKD 328
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAEL 1395
+ +H + +E + ++ R+ + L++ + + ++ ++ + + L
Sbjct: 329 EQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVAL 388
Query: 1396 ESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
+ + + L + QL + +EL+ + E + G D V+ +K
Sbjct: 389 KELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEF 448
Query: 1456 ESQVEEWYRE--VGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLA 1513
S+ RE Q + + + E ++ + E LLE + R +LL A
Sbjct: 449 ASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAA 508
Query: 1514 SKELHQV---AHDLDDELAWVQERLP-LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGP 1569
S+ELH+ A +L ++ + RLP L E ++Q+ ++ ++Q
Sbjct: 509 SRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQLLVS 565
Query: 1570 RLEEVLERAGALASLRSPE-AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYF 1628
++ ++ E A L ++ + E AEA+ +++ W L A E + + + +++
Sbjct: 566 QVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHS 625
Query: 1629 DVAEVEAWLGEQELLMMSEDKGKDEQSTLQL 1659
V ++ +W+ + + DK + S L L
Sbjct: 626 QVRDLLSWMDGIASQIGAADKPRCPSSLLGL 656
Score = 69.3 bits (168), Expect = 5e-11
Identities = 112/605 (18%), Positives = 228/605 (37%), Gaps = 32/605 (5%)
Query: 945 QELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVR 1004
Q+L++ + VR + W + + + ++ + V AE+ ++
Sbjct: 44 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL 103
Query: 1005 EKRRAVESAPRAG--GALQWRLSGLEAALQALEP--RQAALLEEAALLAERFPAQAARLH 1060
++ G + +L L++ +E R+ L+ PA +
Sbjct: 104 HMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVG 163
Query: 1061 QGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN 1120
+ +G L Q + A+ L + HDLD L W+ A +E N
Sbjct: 164 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERG--N 221
Query: 1121 SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELG 1180
L+ + ++ L+ E+ ++ + AL + E A+ L L+
Sbjct: 222 GLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAE---AVRRGLEQLQSA 278
Query: 1181 WHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQ 1240
W L E R++ L A + + D+ + L QE+ + + +S + LK+
Sbjct: 279 WAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKK 338
Query: 1241 HRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQ---AQEAVTRL------LEKNQENQ 1291
H +E ++ + + LL G+ EQ Q V RL L + +
Sbjct: 339 HLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVA 398
Query: 1292 LRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMA-RDGTREDNHKLHKRWLRHQAFM 1350
L Q W+ +L Q+ EL+ WI EK ++A +D + + F
Sbjct: 399 LEQQYWLYQLSRQVS---------ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFA 449
Query: 1351 AELAQ-NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEA 1409
+E +E L + + +L++ AA++ + + + WAEL +A+ L +
Sbjct: 450 SETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAAS 509
Query: 1410 SKADQLVQSFAELDKKLLHMESQLQDV-DPGGDLATVNSQLKKLQSMESQVEEWYREVGE 1468
+ + EL ++ +L + P + +S + L++ E ++ +V +
Sbjct: 510 RELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQ 569
Query: 1469 LQAQTAALPLEPASK--ELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDD 1526
LQ A L A + E + R+ V + LL ++ R + ++ + + + D
Sbjct: 570 LQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD 629
Query: 1527 ELAWV 1531
L+W+
Sbjct: 630 LLSWM 634
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 872 bits (2254), Expect = 0.0
Identities = 665/2274 (29%), Positives = 1069/2274 (47%), Gaps = 109/2274 (4%)
Query: 45 SLFECSRIKALADEREAVQKKTFTKWVNS--HLARVGCHIGDLYVDLRDGFVLTRLLEVL 102
S +E I+ L +Q+KTFTKW+N+ + G I +LY +L DG L RLLE++
Sbjct: 3 SQYETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELI 62
Query: 103 SGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIIL 162
SGE LP P+RGR+R+H LEN +AL FL+ +V + +G +IVDG+ L LGL+W IIL
Sbjct: 63 SGEALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIIL 121
Query: 163 RFQIQVIKIETED---NRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALI 219
RFQI I ++ E+ + S K+ALL+WCQ KTA Y VNI +F+ SW DGL FNALI
Sbjct: 122 RFQISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALI 181
Query: 220 HRHRPDLVDFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVS 279
H HRPDL+D+ L +NL AF AEQ LG+A+LLDPEDV PDE+SI+TYV
Sbjct: 182 HAHRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSL 241
Query: 280 FYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFAN 339
+YHY S++ +R+ K+L Q+ E + +YE+L A+LL WI + + F +
Sbjct: 242 YYHYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPD 301
Query: 340 SLSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDI 399
SL ++Q L AFT + T EKP + Q++G E LLF +Q+ L+A NRR F+P EG G+ ++
Sbjct: 302 SLPAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAEL 361
Query: 400 DKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFG- 458
+ W LE AE R AL+ L++ ++LE LA+RF HK A+RES+L + ++++ Q
Sbjct: 362 SQCWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPP 421
Query: 459 YELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWA 518
L VEAA+++ +EA I E R Q +AE+A L E Y+ VA +++ V +W
Sbjct: 422 ASLATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQ 481
Query: 519 LLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHG 578
L + +R ++ A+ + QE+ +EE+Q S CGQ L E +LLQ+H
Sbjct: 482 RLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRA 638
LLE ++A V L A + ++L +V+ + + L RRA
Sbjct: 542 LLEAQVSAHGAHVSHL---AQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRA 598
Query: 639 ELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLL 698
LE + L+ EE E+W ++ G A DLS A L
Sbjct: 599 LLEQTLQRAEFLRNCEEEEAWLKE---------------CGQRVGNAALGRDLSQIAGAL 643
Query: 699 AQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRL 758
+HK L+ E+ +A+ +R G +L A P ERA + + WQ L
Sbjct: 644 QKHKALEAEVHRHQAVCVDLVRRGRDLSARRPPTQPDP--------GERAEAVQGGWQLL 695
Query: 759 EEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQH--- 815
+ R RLQ A + Q+ AD WLR+ G D+A++ L R+H
Sbjct: 696 QTRVVGRGARLQTALLVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRL 755
Query: 816 ----RALTGEVEA--HRGPVSGLRRQLATLGGA--------SGAGPLVVA---------- 851
RA E+ +G + R L T+ A GP A
Sbjct: 756 ERVLRAFAAELRRLEEQGRAASARASLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAW 815
Query: 852 -----------------LQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACE 894
LQ + Q + + +A LRR L +A+A++ +
Sbjct: 816 KMALPAEPDPDFDPNTILQTQD-HLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQ 874
Query: 895 LWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPS 954
LW+ ++Q +L RV D +EV+Q ++E+ + G +V+ + ++L + +
Sbjct: 875 LWL--EKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGN 932
Query: 955 SDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESA- 1013
S +++ Q+ L+ RW ++ L ++ +++ + V + + E + Q+R+ +E+
Sbjct: 933 STQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQ 992
Query: 1014 PRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGAL 1073
P + L + LE R L + E A++ L E L +
Sbjct: 993 PGSSEDTCHALQLAQKKTLVLERRVHFLQSVVVKVEEPGYAESQPLQGQVETLQGLLKQV 1052
Query: 1074 ASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHA 1133
A Q FL + L W Q E + + A LL H
Sbjct: 1053 QEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSV--DVASAQRLLREHQ 1110
Query: 1134 ALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARRE 1193
L EE+ +E ++ A S+ + A D + + L L +L LWE R++
Sbjct: 1111 DLLEEIHLWQERLQQLDAQSQPMAALDCPD---SQEVPNTLRVLGQQGQELKVLWEQRQQ 1167
Query: 1194 ALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQ 1253
L + Q F R++ N + L L V L+QHR+F +
Sbjct: 1168 WLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGP 1227
Query: 1254 KMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRD 1313
+ + E L++ + +E + + + Q R++Q ++L L+LQ + +D
Sbjct: 1228 RAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQD 1287
Query: 1314 CHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE 1373
EL W+ EK LMA + + RH+A +EL + +E +++ G++L+
Sbjct: 1288 VAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSR 1347
Query: 1374 KPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQL 1433
+P ++ +L +R W L + +L +A + +QL++ + ++L +E L
Sbjct: 1348 RPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGAL 1407
Query: 1434 QDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAV 1493
Q + G DL + K+ Q +ES+ ++ L + + PA E E Q +
Sbjct: 1408 QSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAASPAILE---ETQKHL 1464
Query: 1494 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 1553
RL L L R L AS ELHQ H + EL+WV E +P T L Q
Sbjct: 1465 -RRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSL 1523
Query: 1554 IKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERR 1613
+K++ L+ E++AH +++ VL +LA+ P+A+ + ++L+ WA L A E R
Sbjct: 1524 HRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEAR 1583
Query: 1614 QQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENY 1673
Q L A +QY+ DV+E+E W+ E+ L+ S D G+DE +TL+L+ KH L++ + Y
Sbjct: 1584 AQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIY 1643
Query: 1674 EESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLS 1733
S+ +L + + L P+ +++ Q ++ AL+EL R LE L++
Sbjct: 1644 WSSMEELDQTAQTLTGPEVPEQQRVV--QERLREQLRALQELAATRDRELEGTLRLHEFL 1701
Query: 1734 RQVSELEHWIA-EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVD 1792
R+ +L+ W+A +K+ G LG+D EH L KF++F + M G +R+AA + +
Sbjct: 1702 REAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM-GSQRVAACRLLAE 1760
Query: 1793 ELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEE 1852
L+E GH+A + + + L AW+EL EL R L + + D E+ Q++E
Sbjct: 1761 SLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQE 1820
Query: 1853 KRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEA 1912
K LP + R+ + E +L Q+++L E A +++ + G A A
Sbjct: 1821 KATSLP--NNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHA 1878
Query: 1913 IASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPR 1972
+ R+Q V Q W L E R + RF + VRD SW + + + +
Sbjct: 1879 VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQ 1938
Query: 1973 DVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEE 2032
+ SS + ++ HQ L+ ELEAR +LG+ LL E+Q +L L ++++
Sbjct: 1939 EPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQ 1998
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEA 2092
V + W R E LQ + F +E + L AQE L++ LGSSV+EVEQLIR+HE
Sbjct: 1999 VYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEV 2058
Query: 2093 FRKAAAAWEERFSSLR-RLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPG 2151
F K A +++ ++LR RL T+ + + + + P LL R+ ELA L
Sbjct: 2059 FLKVLTAQDKKEAALRERLKTLRRPRV-RDRLP--ILLQRRM--RVKELAESRGHALHAS 2113
Query: 2152 GYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALPAAP 2211
A +A D + A + +++ + P L+ D+L + A A
Sbjct: 2114 LLMASFTQAATQAEDWIQAWAQ----QLKEPVPPGDLR---DKLKPLLKHQAFEAEVQAH 2166
Query: 2212 EDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRR 2265
E+ + A A + P E + R + L + RQ + +E RR
Sbjct: 2167 EEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRR 2220
Score = 441 bits (1135), Expect = e-123
Identities = 439/1763 (24%), Positives = 762/1763 (43%), Gaps = 114/1763 (6%)
Query: 398 DIDKAWGELEKAEHEREAALRAE----LIRQEKLELLAQRFDHKVAMRESWLNENQRLVS 453
D+ AW EL + R ALR + ++ LE+L Q + ++
Sbjct: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
Query: 454 QDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELA---QALAAEGYYDIRRVAAQR 510
+N +L +EA ++ H+ +E ++ E ++Q + E A Q L V ++
Sbjct: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGP--QAHAVQQRQ 1883
Query: 511 DSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEA 570
+V + WA+L + RR +LE+ L + + W ++ L E Q
Sbjct: 1884 QAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSG 1943
Query: 571 DDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQ 630
L H L ++ A+ E L A + Q P E+Q
Sbjct: 1944 PLKLSAHQWLRAELEAR----EKLWQQATQLGQQALLAAGTPT-------------KEVQ 1986
Query: 631 EQAARRRAELEASRSLWALLQELEEAES----WARDKERLLEAAGGGGAAGAAGAAGTAG 686
E+ + + + WA QE +AE + R+ RL E + A G++
Sbjct: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSS- 2045
Query: 687 GAHDLSSTARLLAQHKILQGELGG---RRALLQQALRCGEELVAAGGAVGPGADTVHLVG 743
+ +L+ +H++ L + A L++ L+ T+
Sbjct: 2046 ----VEEVEQLIRKHEVFLKVLTAQDKKEAALRERLK-----------------TLRRPR 2084
Query: 744 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRD-AYRLAAAGDFG 802
+ +R +R R++E A R L + + F DW++ A +L G
Sbjct: 2085 VRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
Query: 803 HDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQL 862
D + +H+A EV+AH ++ + ++ L S P + R+ +
Sbjct: 2145 -DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSH--PRAGEVSQRLQGLRKH 2201
Query: 863 FAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVE-VVQH 921
+ ++ + ALR Q L D V E WI EKE + M V D D+E +Q
Sbjct: 2202 WEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKE---VKMNVGDLGQDLEHCLQL 2258
Query: 922 RFESLDQEMNSLMGRVLDVN-HTVQEL-VEGGHPSSDEVRS-CQ--DHLNSRWNRIVELV 976
R + NS V D ++ +L ++ + +EV+ CQ LN+RW +
Sbjct: 2259 RRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNL 2318
Query: 977 EQRKEEMSAVLLVENHVL--EVAEVRAQVREKRRAVESAP-----RAGGALQWRLSGLEA 1029
+ ++++ L E HVL E+ V +++EK +++ + L + LE
Sbjct: 2319 LRYQQQLEGAL--EIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELER 2376
Query: 1030 ALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAA--- 1086
+ ++ + +L E L +R P A L +E+ W L S AQ EA+ A
Sbjct: 2377 EVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQ 2436
Query: 1087 AGRLQRFLHDLDAFLDWLVRAQEAAGGSE-GPLPNSLEEADALLARHAALKEEVDQREED 1145
A +LQ L +L LV AQ + P P S EA +L H K E+D +
Sbjct: 2437 AQKLQAMLQEL------LVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDS 2490
Query: 1146 YARIVAASEALLAADGAELGPGLALD--EWLPHLELGWHKLLGLWEARREALVQAHIYQL 1203
+ + + LL A G + D + L LE L G W+ + L QA QL
Sbjct: 2491 ISLARSTGQQLLTA-----GHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQL 2545
Query: 1204 FLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAE 1263
FL + + L ++E +L+ L + +E L +H+ +E+ K+ A
Sbjct: 2546 FLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATAR 2605
Query: 1264 GLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE 1323
GL + G+ + A +L + + +A +L + +LQ FL+D E+ W+ E
Sbjct: 2606 GLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE 2665
Query: 1324 KMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK 1383
K L+A + D L + + Q F AEL + ++++REGQ+L+Q + ++++
Sbjct: 2666 KNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQE 2725
Query: 1384 KLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLA 1443
+L E+ W EL+ +Q K +L +A +A +L +S EL+ L +E +L+ G L
Sbjct: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALP 2785
Query: 1444 TVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLE 1502
V L + +E+ V++ R+ L Q A E + V E+ + +R L E
Sbjct: 2786 GVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE 2845
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
PLQERR L A L + D D+E+AWVQE+LPLA + G L AV+ +++Q L
Sbjct: 2846 PLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLES 2905
Query: 1563 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 1622
E+ +H VL L A V ++QL+ A A LR A RR+ +L A +
Sbjct: 2906 EMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQE 2965
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 1682
+Q+ ++ E +WL E+ ++ SED G ++T LL++ ++ +E + I +L +
Sbjct: 2966 AQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQ 3025
Query: 1683 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHW 1742
L +P+S ++ + V + L E R L++Q L+QL R+ L+ W
Sbjct: 3026 TAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAW 3085
Query: 1743 IAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
+ K A S + GQD E V VL+EKF F E G+ ++ A+ ++ L
Sbjct: 3086 LTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRY 3145
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTT 1862
+ + + AW L + + R + LAA+ E+H F A ELQG+++EK L +
Sbjct: 3146 PHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEK-TALMKGED 3204
Query: 1863 PPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ 1922
S ++Q+ R E +L+ + +V +LQ A +L G+ A +V +
Sbjct: 3205 GGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL-----GQLHPAAPGGLAKVQE 3259
Query: 1923 GWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMN 1982
W L + ++ ++ A F + ++LL+W + + DV+ E L+
Sbjct: 3260 AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLG 3319
Query: 1983 YHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWE 2042
H+ L E+ + ++ G+ L+ N M+ E+ L +L R +E+ E W W+
Sbjct: 3320 QHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQ 3379
Query: 2043 WLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEE 2102
+ + + Q A+AWL E LL + G SV +VE L+ RH+ K AA EE
Sbjct: 3380 RCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEE 3439
Query: 2103 RFSSLRRLTTIEKIKAEQSKQPP 2125
+F+ +++ +++ + + P
Sbjct: 3440 KFAQMQKTEMEQELLLQPQELKP 3462
Score = 317 bits (813), Expect = 7e-86
Identities = 510/2245 (22%), Positives = 885/2245 (39%), Gaps = 259/2245 (11%)
Query: 424 QEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEE 483
Q +EL +F H M SW+ E+ S ++ L ++ +KH+ ++ ++ A++
Sbjct: 1482 QASVEL--HQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQG 1539
Query: 484 RVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQE 543
+VQ V ++LAA G+ + + Q + WA L AR L+Q + Q+ F +
Sbjct: 1540 QVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLD 1599
Query: 544 MVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQ 603
+ + W+EE + + SR+ G+ L+ KH L+ ++A +E L+ A
Sbjct: 1600 VSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTA---QT 1656
Query: 604 LQGYQ-PCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARD 662
L G + P +V+ R+ L LQE AA R ELE + L L+E E+ + W
Sbjct: 1657 LTGPEVPEQQRVVQERLREQ---LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLAS 1713
Query: 663 KERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCG 722
++ +AA GG + G H + A+ QH++ E+G +R + L
Sbjct: 1714 QK---QAAKGGESLGE----DPEHALHLCTKFAKF--QHQV---EMGSQRVAACRLL--A 1759
Query: 723 EELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADL 782
E L+ G + GP + +R + W L E R L++ + DL
Sbjct: 1760 ESLLERGHSAGPM--------VRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDL 1811
Query: 783 DGLLDWLRDAYRLAAAGDFGHDEASS--RRLARQHRALTGEVEAHRG---PVSGLRRQLA 837
+L +++ +A+S +AR L ++ +H+G + G RQL
Sbjct: 1812 LEVLTQVQE-------------KATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQ 1858
Query: 838 TLGGASGA------GPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVH 891
L +G GP A+Q R Q +A + RR L A + R V
Sbjct: 1859 ELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVR 1918
Query: 892 ACELWIGEKEQWLL---SMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV 948
W Q L S + P S +++ H++ + E + + Q L+
Sbjct: 1919 DYASWAARVRQDLQVEESSQEPSS-GPLKLSAHQWLRAELEAREKLWQQA-TQLGQQALL 1976
Query: 949 EGGHPSSD---EVRSCQDHLNS---RWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQ 1002
G P+ + E+R+ QD + W R E ++ ++E + L E LE +
Sbjct: 1977 AAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQ--LFLRECGRLEEILAAQE 2034
Query: 1003 VREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLA-----ERFPAQAA 1057
V K A+ S+ L + L A + ++AAL E L +R P
Sbjct: 2035 VSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQ 2094
Query: 1058 RLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP 1117
R + E A++ G A+ A+ + F DW+ Q A + P
Sbjct: 2095 RRMRVKE-----------LAESRGHALHASLLMASFTQAATQAEDWI---QAWAQQLKEP 2140
Query: 1118 LP-NSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
+P L + L +H A + EV EE + EALLA G + + L
Sbjct: 2141 VPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGE---VSQRLQG 2197
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
L W L R + L + FL+ + A ++ +E+ ++ +L +E +
Sbjct: 2198 LRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQ 2257
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQE------N 1290
++ R+F ++ L+ N E+ + R + N N
Sbjct: 2258 LRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGN 2317
Query: 1291 QLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEK--MLMARDGTREDNHKLHKRWLRHQA 1348
LR QQ +L LE+ R+ + I EK ++ A D +D + + +H+
Sbjct: 2318 LLRYQQ---QLEGALEIHVLSRELDNVTKRIQEKEALIQALD-CGKDLESVQRLLRKHEE 2373
Query: 1349 FMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFE 1408
E+ + +E +ERE +L Q PE A +R + E+ + W +L S Q + L
Sbjct: 2374 LEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA 2433
Query: 1409 ASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY----- 1463
+A +L EL + +Q+ L++ Q +++++ W
Sbjct: 2434 LHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISL 2493
Query: 1464 -REVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 1522
R G+ Q TA P ++++ + + L L QE + L + EL
Sbjct: 2494 ARSTGQ-QLLTAGHPFSSDIRQVLA----GLEQELSSLEGAWQEHQLQLQQALELQLFLS 2548
Query: 1523 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 1582
++ W+ + + L ++ + K++ L +++ ++ + A L
Sbjct: 2549 SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLH 2608
Query: 1583 SLRSPEAE-AVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQE 1641
PEA+ A+ R L A R+A RR + L+ Q++ + D EV AWL E+
Sbjct: 2609 QGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHR-LEELRQLQAFLQDSQEVAAWLREKN 2667
Query: 1642 LLMMSEDKGKDEQSTLQLLKK-HLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISR 1700
L+ + E QL K+ + Q E +++ +L R+ + LL+ GHP SE I
Sbjct: 2668 LVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQ--ELQREGQRLLQGGHPASEAIQE 2725
Query: 1701 RQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760
R ++ L+ L++ +++ L++ +L R + ELE+W+ EV +P +GQ
Sbjct: 2726 RLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALP 2785
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELL 1820
V L E + R+ A + Q + GH A + E L + + L
Sbjct: 2786 GVGELLGTQRELEAAVDKKARQAEALLGQ-AQAFVREGHCLAQDVEEQARRLLQRFKSLR 2844
Query: 1821 ELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAF 1880
E + R L A L KFF DA E ++EK LP L + S S++ R L+
Sbjct: 2845 EPLQERRTALEARSLLLKFFRDADEEMAWVQEK---LP-LAAAQDYGQSLSAV-RHLQEQ 2899
Query: 1881 EHDLQLLVSQVRQLQEGA--AQLRTVYAGEHA-EAIASREQEVLQGWKELLSACEDARLH 1937
+L+ +S L + V AG A +A+R Q++ + L + RL
Sbjct: 2900 HQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLL 2959
Query: 1938 VSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPE 1997
+ +A +F +++ + SW+ + + D + + L+ + K +LEA P
Sbjct: 2960 LQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPR 3019
Query: 1998 LTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEA 2057
+ Q+ L K+ + ++ AQL + E+ + + LQ+ L++HQ +E
Sbjct: 3020 IERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERET 3079
Query: 2058 VVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW-EERFSSLRRLT-TIEK 2115
++ DAWLT + +S++ G ++ V+ L + +AFRK + + + +LR+L T+E+
Sbjct: 3080 LLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLER 3139
Query: 2116 --------IKAEQSK-QPPTPLLGRKFFGDPTELAA--------KAAPLLRPGGYERGLE 2158
I+A++S+ + L + LAA +AA L+ E+
Sbjct: 3140 GAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTAL 3199
Query: 2159 PLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIP---GRVEPAALPAAPEDAA 2215
+LS+ + + R E + E ++ + RL G++ PAA P
Sbjct: 3200 MKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAA-PGGLAKVQ 3258
Query: 2216 ETPATPAAAEQVRPR----------------------PERQESAD--------------- 2238
E AT A Q R + ERQE A
Sbjct: 3259 EAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQLL 3318
Query: 2239 -RAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERR----- 2292
+ EEL + R R ++ D +E + SAE GR +++E
Sbjct: 3319 GQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRW 3378
Query: 2293 --------RERRERRLERQES------------------SEQEMPIRG--DLVKGKATLA 2324
++ +RLE+ E+ S+ E+ + DL K A
Sbjct: 3379 QRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQE 3438
Query: 2325 DIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRP 2384
+ Q+Q+ E L L QP+EL PGR + L + P
Sbjct: 3439 EKFAQMQKTEMEQEL-----LLQPQELKPGRAGSSLTSFQWRP----------------- 3476
Query: 2385 RPREGGEGGGSRRSRSAPAQGGSAPAPPPPPTHTVQHEGFLLRKREL-DANRKSSNRSWV 2443
G +G G++ + + Q T EG L K+ L R+ S+ SW
Sbjct: 3477 ---SGHQGLGAQLAETRDPQDAKG---------TPTMEGSLEFKQHLLPGGRQPSSSSWD 3524
Query: 2444 SLYCVLSKGELGFYKDSKGPASGSTHGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGS 2503
S L L + D + A LL L A E +KH F L+ G+
Sbjct: 3525 SCRGNLQGSSLSLFLDERMAAEKVA--SIALLDLTGARCERLRGRHGRKHTFSLRLTSGA 3582
Query: 2504 EFLLQAKDEEEMNGWLEAVASSVAE 2528
E L A EE+ W A+ S+ A+
Sbjct: 3583 EILFAAPSEEQAESWWRALGSTAAQ 3607
Score = 183 bits (465), Expect = 2e-45
Identities = 238/1070 (22%), Positives = 434/1070 (40%), Gaps = 118/1070 (11%)
Query: 287 MKALAVEGKRIGKVLD------QVLEVGKIIERYEELAAELLAW-----IHRTVG---LI 332
++ L V +R+ +D +E +++E ++E AEL +W + R+ G L
Sbjct: 2444 LQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLT 2503
Query: 333 SNQKFANS----LSGVQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLR-ACNRRL 387
+ F++ L+G++Q+L + E ++ Q+ L++ L S++ R C++
Sbjct: 2504 AGHPFSSDIRQVLAGLEQELSSLEG-AWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
Query: 388 FVPREGCG----------------IWDIDKAWGELEKAE-----------HEREAAL--- 417
+ EG WD++ G++ E E ++AL
Sbjct: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRC 2622
Query: 418 RAELIRQEKLELLAQRFDHKV-AMRE------------SWLNENQRLVSQDNFGYELPAV 464
+A L+R+E L A H++ +R+ +WL E + LV+ + + +
Sbjct: 2623 QAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEEGLLDTAML 2681
Query: 465 EAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLV 524
A ++K + +A++ A + Q + Q L G+ + + + + W L
Sbjct: 2682 PAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNS 2741
Query: 525 GARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDI 584
+ +L++ ++ + M + +W+E ++ +L + GQ L +LL LE +
Sbjct: 2742 QKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAV 2801
Query: 585 AAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASR 644
++ + EAL A F + +G+ C Q + + + L+E RR LEA
Sbjct: 2802 DKKARQAEALLGQAQAFVR-EGH--CLAQDVEEQARRLLQRFKSLREPLQERRTALEARS 2858
Query: 645 SLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKIL 704
L ++ +E +W ++K L A G LS+ L QH+ L
Sbjct: 2859 LLLKFFRDADEEMAWVQEKLPLAAAQDYG---------------QSLSAVRHLQEQHQNL 2903
Query: 705 QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVG--LAERAASARRRWQRLEEAA 762
+ E+ AL + L G +LV AG H +A R + L A
Sbjct: 2904 ESEMSSHEALTRVVLGTGYKLVQAG----------HFAAHEVAARVQQLEKAMAHLRAEA 2953
Query: 763 ARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEV 822
ARR LQ+A+ QF +L WL + + + D GH +++ L R+ A ++
Sbjct: 2954 ARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDL 3013
Query: 823 EAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALA 882
EA + L++ A L V Q++ V + AE+ A R L++ L
Sbjct: 3014 EAFSPRIERLQQTAALLESRKNPESPKVLAQLQAV--REAHAELLRRAEARGHGLQEQLQ 3071
Query: 883 VYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSL-MGRVLDVN 941
++++ E + W+ K S L+ V+V++ +F++ +E+ SL +V +
Sbjct: 3072 LHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALR 3131
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
L G +++ + + + W R+ + ++ R E ++A V + AE++
Sbjct: 3132 KLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQG 3191
Query: 1002 QVREKRRAVESAPRAGG-------ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPA 1054
+++EK ++ GG LQ + LE L+A+E A L EA L + PA
Sbjct: 3192 RMQEKTALMKG--EDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPA 3249
Query: 1055 QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGS 1114
G ++ W L + AQ G+ +A A + FL L W QE A
Sbjct: 3250 APG----GLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSE 3305
Query: 1115 EGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWL 1174
E L + A+ LL +H L +E+ RE E D + + E L
Sbjct: 3306 E--LAEDVAGAEQLLGQHEELGQEI--RECRLQAQDLRQEGQQLVDNSHF-MSAEVTECL 3360
Query: 1175 PHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESV 1234
LE +L W R + ++ Q + L QA L E L + +V V
Sbjct: 3361 QELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDV 3420
Query: 1235 EEALKQHRDFLTTMELSQQK---MQVAVQAAEGLLRQGNIYGEQAQEAVT 1281
E L +H+D + ++K MQ E LL+ + +A ++T
Sbjct: 3421 ELLLHRHQDLEKLLAAQEEKFAQMQKTEMEQELLLQPQELKPGRAGSSLT 3470
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 433 bits (1114), Expect = e-121
Identities = 356/1412 (25%), Positives = 621/1412 (43%), Gaps = 102/1412 (7%)
Query: 744 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGH 803
+ ER R+ R +E + R ++L+++ F D + L W+++ ++A+ ++
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
Query: 804 DEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVA--------LQVR 855
D + + ++H+A EV+A+ G + L G L+++ ++ R
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDE----------TGNLMISEGHFASETIRTR 123
Query: 856 VVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDD 915
++E + + + E + L A + + E WI +KE + S + L+
Sbjct: 124 LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEH 183
Query: 916 VEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVEL 975
VEV+Q +FE +M + RV +VN +L++ HP + +++ QD +N+ W R+ L
Sbjct: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL 243
Query: 976 VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAP-----RAGGALQWRLSGLEAA 1030
QR+ ++ V+ +V E + ++EK + + S + AL + GLE
Sbjct: 244 ALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERD 303
Query: 1031 LQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL 1090
L ALE + AL EA L + P A ++ EEL W + + A + + RL
Sbjct: 304 LAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
Query: 1091 QRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIV 1150
QRFL D W+ + E L + + A+ALL RH K E+D E+ +
Sbjct: 364 QRFLADFRDLTSWVTEMKALINADE--LASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
Query: 1151 AASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQ 1210
+ +ALLAA + E L L LL LWE RR+ Q QLF RD Q
Sbjct: 422 ESGQALLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQ 478
Query: 1211 ALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGN 1270
+ QE L +L +++SVE LK+H DF ++ ++K+ + A L++ +
Sbjct: 479 VDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538
Query: 1271 IYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARD 1330
E LL + RA + +L D LQ F RD EL W++EKM A D
Sbjct: 539 YAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD 598
Query: 1331 GTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
+D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V ++ E+
Sbjct: 599 EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVIS 658
Query: 1391 CWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK 1450
W +L T+ K +L EA++ Q ++ +++ L +E L D G DL V + K
Sbjct: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQK 718
Query: 1451 KLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLLEPLQER 1507
K +E+ V + + Q A + A E + ++Q A+ R L EP+ R
Sbjct: 719 KHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVAR 776
Query: 1508 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 1567
++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+ EI H
Sbjct: 777 KQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGH 836
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ + Q +QY+
Sbjct: 837 EPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYF 896
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L Q ++
Sbjct: 897 ADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC 956
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR--------QVS 1737
+ P ++ + L +AL + E+ R V +++ L L+ +V+
Sbjct: 957 RQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
+ + ++ V P Q ++L+E+ S +A + +D
Sbjct: 1011 DRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQIDNQTRI 1055
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
A + K + E + LLEL R +L S + F +A ELQ I EK L
Sbjct: 1056 TKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV-YAGEHAEAIASR 1916
+ +Q+ F+ DL+ S+++ + + A L + E +A+ +
Sbjct: 1115 TSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
Query: 1917 E----------------------------------QEVLQGWKELLSACEDARLHVSSTA 1942
E +E+ + W+ L E+ + S
Sbjct: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Query: 1943 DALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQ 2002
+ RFH + W++ + + D++SV+ L H+G + +L A ++ +
Sbjct: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Query: 2003 ELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA 2062
E L+ + A+++Q + +L + ++ D+ L ++ +F + +
Sbjct: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
Query: 2063 WLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094
W+ L+ S EL V E L+ RH+ R
Sbjct: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
Score = 417 bits (1073), Expect = e-116
Identities = 419/1808 (23%), Positives = 767/1808 (42%), Gaps = 172/1808 (9%)
Query: 320 ELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP-VKFQEKGNLEVLLFSI 376
EL +W++ + +++ + + +L G Q+ QAF A + + + EK +++ +
Sbjct: 584 ELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
Query: 377 QSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDH 436
+K R + ++ W +L +A + LR E +Q Q+F+
Sbjct: 644 YAKDEVAAR----------MNEVISLWKKLLEATELKGIKLR-EANQQ-------QQFNR 685
Query: 437 KVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALA 496
V E WL E + ++ D++G +L V+ KKH +EAD+AA+++R+ G+ A+
Sbjct: 686 NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
Query: 497 AEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQA 556
G++D + ++++++ ++ L + AR+ +L +L LQ++F+++ W+ E +
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
Query: 557 QLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVIC 616
S G+ L+ +LL+KH L+ +IA R++A+ + + D +
Sbjct: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
Query: 617 NRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAA 676
+ +N L + +A++RR +LE S + EAESW R+KE ++
Sbjct: 866 HELNQKWEAL---KAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV--------- 913
Query: 677 GAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGA 736
G+ D S LL +H+ L +L A G ++
Sbjct: 914 ------GSTDYGKDEDSAEALLKKHEALMS-----------------DLSAYGSSIQ--- 947
Query: 737 DTVHLVGLAERAASARRRWQRLEEAAARR------ERRLQEARALHQFGADLDGLLDWL- 789
L E+A S R++ ++ + + + + R + D+ LL+
Sbjct: 948 ------ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
Query: 790 RDAYRLAAAGDFGHDEASS-RRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848
+D +++ G A+ ++L A + +G ++ + Q+ +
Sbjct: 1002 KDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGS 1061
Query: 849 VVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMR 908
V +R+ + E+L+ + E+ R+ L + + +F E + + WI EKE L S
Sbjct: 1062 V---SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118
Query: 909 VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDH---- 964
V L+ VEV+Q +F+ +++ + R+ D+N ++L G ++EV++ Q
Sbjct: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGL-MAEEVQAVQQQEVYG 1177
Query: 965 ---------------------------------LNSRWNRIVELVEQRKEEMSAVLLVEN 991
LN RW + +L E+R + + + V+
Sbjct: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQR 1237
Query: 992 HVLEVAEVRAQVREKRRAVESAPRAGG-----ALQWRLSGLEAALQALEPRQAALLEEAA 1046
+ E + + EK +A+ + ALQ + G E L AL + +L E A
Sbjct: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
Query: 1047 LLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVR 1106
L + P A L + EL W +L A + + LQRFL D + W+
Sbjct: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
Query: 1107 AQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGP 1166
+ E L + A+ALL RH + E+D R + + LLA G P
Sbjct: 1358 IRGLVSSDE--LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA-HGHYASP 1414
Query: 1167 GLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAE 1226
+ + L L+ L W RR L Q QLF RD QA + +E L+ +
Sbjct: 1415 --EIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED 1472
Query: 1227 LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEK 1286
+++SVE +K+H DF + + ++K+ A+ L+ G+ +L++
Sbjct: 1473 KGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
Query: 1287 NQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRH 1346
+ + + + KL + LQ F RD E++ WI EK+ A D + +D + + +H
Sbjct: 1533 WRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKH 1592
Query: 1347 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKKLGEIRQCWAELESTTQAKA 1403
QAF AEL N + + + G L+ E+ A S V+ +L + W L + K+
Sbjct: 1593 QAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKARLAALADQWQFLVQKSAEKS 1651
Query: 1404 RQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWY 1463
++L EA+K + D L +E+ L D G DLA+VN+ LKK Q +E+ +
Sbjct: 1652 QKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHE 1711
Query: 1464 REVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH 1522
+ +L +Q +L A V ++++ + R ++ RR L S LHQ
Sbjct: 1712 DRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1771
Query: 1523 DLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALA 1582
D+DDE +W++E+ L + G L VQ KK++ L E+ AH P ++ VL+ L+
Sbjct: 1772 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLS 1831
Query: 1583 SLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQEL 1642
+ E +++ L Q W L++ A R Q L+ + + +Q+ +V E EAW+ E+
Sbjct: 1832 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1891
Query: 1643 LMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQ 1702
L+ SED G + LLKKH E +++ + + + L++ + E IS +
Sbjct: 1892 LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKM 1951
Query: 1703 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 1762
++ L++ +R+ L++ Q + + +E WI EKE + + G+D V
Sbjct: 1952 KGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV 2011
Query: 1763 SVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLEL 1822
L K F + +E +A + + D+L+ H + + L + W++LL
Sbjct: 2012 QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLAN 2071
Query: 1823 MGTR-AQLLAASRELHK-------FFSDARELQGQIEEKRR------RLPRLTTPPEPRP 1868
R +LL A K F A E R L R
Sbjct: 2072 SAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALRE 2131
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQ--EGAAQLRTVYAGEHAEAIASREQEV-----L 1921
+ + + +L + + D L RQ++ A+ T + E E Q++ L
Sbjct: 2132 AHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKEREL 2191
Query: 1922 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSW-MDG--IASQIGAADKPRDVSSVE 1978
+ KE E+ +L A FH +++ ++ +DG + + G + S +E
Sbjct: 2192 ELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE-----SQLE 2246
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRS-----LLLNKSAMADEIQA-----QLDKLGT 2028
HQ E+ A +L ++LG + +L NK + QLD+LG
Sbjct: 2247 ATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2302
Query: 2029 RKEEVSEK 2036
R + E+
Sbjct: 2303 RMQHNLEQ 2310
Score = 374 bits (959), Expect = e-103
Identities = 402/1870 (21%), Positives = 768/1870 (41%), Gaps = 149/1870 (7%)
Query: 311 IERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLE 370
++R+ +L +W+ LI+ + A+ ++G + L + KG ++
Sbjct: 363 LQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEID 411
Query: 371 VLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLE-- 428
S +S + L G + D+ +L ER A L +R+++ E
Sbjct: 412 AHEDSFKSADESGQALL-----AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQC 466
Query: 429 LLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGV 488
+ Q F ++W+++ + + ++ G L +VEA +KKHE E ++A EE++ +
Sbjct: 467 MDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Query: 489 AELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMV 548
E A L +Y + VA +RD++L + L RR +L + LQ+ F++ +
Sbjct: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELK 586
Query: 549 DWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQ 608
W+ E + + + E + +QKH E +++A R++AL A + + Y
Sbjct: 587 SWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA 645
Query: 609 PCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLE 668
+ + R+N V +L E + +L + + +E+ E W + E L
Sbjct: 646 KDE---VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA 702
Query: 669 AAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAA 728
+ G DL++ L +H +L+ ++ + + + A
Sbjct: 703 SDDYG---------------KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
Query: 729 GGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDW 788
G + ++ + R++ L+E R+++L ++ L Q D++ W
Sbjct: 748 GH--------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETW 799
Query: 789 LRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848
+R+ +AA+ + G D + L ++H+AL E+ H + + ++ G A
Sbjct: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK----GNAMVEEGH 855
Query: 849 VVA--LQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906
A ++ ++ E Q + + A+ RRQ L D+L + F + + E W+ EKE + S
Sbjct: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
Query: 907 MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966
D E + + E+L ++++ + + Q + P+ DE
Sbjct: 916 TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK------ 969
Query: 967 SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEV------RAQVREKRRAVESA------P 1014
++ L + +++ V + + +L + + +V +++ V +A P
Sbjct: 970 ---ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
Query: 1015 RAGGALQWRLS--GLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGA 1072
+ + L G A Q Q + +EA ++ R Q L+ ELG +
Sbjct: 1027 AQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMK-QVEELYHSLLELGEKRKG 1085
Query: 1073 LASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP--LPNSLEEADALLA 1130
+ + A LQ+++++ +A L ++E E L ++ L
Sbjct: 1086 MLEKSCKKFMLFREANELQQWINEKEAALT----SEEVGADLEQVEVLQKKFDDFQKDLK 1141
Query: 1131 RHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDE--------W--------- 1173
+ + +++++ ED +E + A E+ + DE W
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
Query: 1174 ------LPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAEL 1227
+ L W L L E R + L AH Q F RD + + + AL+
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
Query: 1228 PGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKN 1287
+ SV+ ++H F + K+ + AE L++ E QE T L +
Sbjct: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAW 1321
Query: 1288 QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRH 1346
RA Q KL D +LQ FL D +L WI+ + L++ D +D RH
Sbjct: 1322 SSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERH 1381
Query: 1347 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 1406
Q E+ + E+ GQQL+ + +++KL + Q A+LE + L
Sbjct: 1382 QEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMML 1441
Query: 1407 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 1466
+ + + + + + E+ L D G L +V + +KK + + + ++
Sbjct: 1442 DQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKI 1501
Query: 1467 GELQAQTAAL-PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 1525
LQA L +K + R+N V +R RL + E+R L S+ L Q + D+D
Sbjct: 1502 AALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD 1561
Query: 1526 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 1585
+ AW+ E+L A + +H +K+Q E+ A+ R+ V++ +L
Sbjct: 1562 EIEAWISEKLQTASDESYKDPTNIQSKH-QKHQAFEAELHANADRIRGVIDMGNSLIERG 1620
Query: 1586 S--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELL 1643
+ +AV+ L L W L + + + Q L A + + + + + + WL E E L
Sbjct: 1621 ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEAL 1680
Query: 1644 MMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 1703
+ SED GKD S LLKKH LE + +E+ + L+ Q +L+ D+ Q+ ++
Sbjct: 1681 LASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD 1740
Query: 1704 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 1763
++ + +K + RR L + + L+Q R + + E WI EK+++ GS + G+D V
Sbjct: 1741 TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ 1800
Query: 1764 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN-------EAW 1816
L++K +E LAA + +++ G + K+ + E W
Sbjct: 1801 NLRKKHKRLEAE--------LAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHW 1852
Query: 1817 AELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRT 1876
EL +L R Q L S E +F ++ E + I EK L + + +++Q
Sbjct: 1853 KELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT----LVASEDYGDTLAAIQGL 1908
Query: 1877 LR---AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW-KELLSACE 1932
L+ AFE D + +V + L + H E S + + L G +L A
Sbjct: 1909 LKKHEAFETDFTVHKDRVNDVCTNGQDL--IKKNNHHEENISSKMKGLNGKVSDLEKAAA 1966
Query: 1933 DARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELE 1992
+ + + L+F+ + + SW+ + + D RD+SSV+ L+ + L+
Sbjct: 1967 QRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQ 2026
Query: 1993 ARVPE-LTTCQELGRSLLLNKSAMADEIQAQ-----------LDKLGTRKEEVSEKWDRH 2040
A E + L LL K + I+A+ L RK+++ E H
Sbjct: 2027 AFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEA-QSH 2085
Query: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
+ ++ + FA++A ++W E L +S++E++ L H+AFR + ++
Sbjct: 2086 FRKVEDLFLT--FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSA 2143
Query: 2101 EERFSSLRRL 2110
+ F+ L L
Sbjct: 2144 QADFNQLAEL 2153
Score = 350 bits (897), Expect = 1e-95
Identities = 405/1897 (21%), Positives = 792/1897 (41%), Gaps = 133/1897 (7%)
Query: 258 LDPEDVNM--EAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYE 315
+DP V + A D + V+ YH F ++ L Q LE + ++
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLR----------RQKLEDSYRFQFFQ 50
Query: 316 ELAAELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP--VKFQEKGNLEV 371
A EL WI + + S++ + + +L G Q+ QAF A VK E GNL +
Sbjct: 51 RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI 110
Query: 372 LLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLA 431
S+ RL ++ + W L E RE ++ L++ +KL
Sbjct: 111 SEGHFASE--TIRTRLM---------ELHRQWELL--LEKMREKGIK--LLQAQKLVQYL 155
Query: 432 QRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAEL 491
+ + + W+N+ + +V+ + G +L VE KK E + D+AA+EERV V +
Sbjct: 156 RECEDVM----DWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
Query: 492 AQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWM 551
A L E + + + ++D V W L GL R+ +L +Q+ +++ + W+
Sbjct: 212 AAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWI 271
Query: 552 EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCD 611
+E + + S + G+ L LL+KH LE D+AA ++V+AL A A +LQ P
Sbjct: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEA---DRLQQSHPLS 328
Query: 612 PQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAG 671
I + + +++ AA R A L S L L + + SW + + L+ A
Sbjct: 329 ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINA-- 386
Query: 672 GGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGA 731
A D++ LL +H+ +GE+ + A G+ L+AAG
Sbjct: 387 -------------DELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHY 433
Query: 732 VGPGADTVH--LVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWL 789
+D V L L+E A+ W+ R ++ ++ L F D + + +W+
Sbjct: 434 ---ASDEVREKLTVLSEERAALLELWE-------LRRQQYEQCMDLQLFYRDTEQVDNWM 483
Query: 790 RDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLV 849
D G S L ++H + A ++ L L +
Sbjct: 484 SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
Query: 850 VALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRV 909
VA + + + + + E A RR L D+ + + F + + W+ EK +
Sbjct: 544 VATRRDALLSRR--NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
Query: 910 PDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRW 969
D + VQ + ++ + E+++ R+ + Q+L++ H + DEV + + + S W
Sbjct: 602 KDPSNLQGKVQ-KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 970 NRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGA-----LQWRL 1024
+++E E + ++ + V ++ + E + S LQ +
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 1025 SGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAV 1084
+ LEA + A + R + +A + A + + E L A + AL A + +
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 1085 AAAGRLQRFLHDLDAFLDWLVRAQE--AAGGSEGPLPNSLEEADALLARHAALKEEVDQR 1142
A + RLQ+ D++ W +R +E AA + G L LL +H AL+ E+
Sbjct: 781 ADSLRLQQLFRDVEDEETW-IREKEPIAASTNRG---KDLIGVQNLLKKHQALQAEIAGH 836
Query: 1143 EEDYARIVAASEALLAADGAELGPGLALD--EWLPHLELGWHKLLGLWEARREALVQAHI 1200
E + A++ E G A D L L W L RR+ L +
Sbjct: 837 EPRIKAVTQKGNAMV-----EEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
Q + D +A +R +E + + +S E LK+H ++ + +Q +
Sbjct: 892 AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
Query: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLR------DC 1314
A+ +Q ++ + + L QE R + K D L L + +
Sbjct: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPR--EVTMKKGDILTLLNSTNKDWWKVEV 1009
Query: 1315 HELDGWIH----EKMLMARDGTRED------NHKLHKRWLRHQAFMAELAQNKEW-LEKI 1363
++ G++ +K+ A+ +RE+ + L + + +Q + + A + ++++
Sbjct: 1010 NDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV 1069
Query: 1364 EREGQQLMQ----EKPELAASVRK-----KLGEIRQCWAELESTTQAKARQLFEASKADQ 1414
E L++ K L S +K + E++Q W + + + +
Sbjct: 1070 EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEV 1128
Query: 1415 LVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQT 1473
L + F + K L ES+L+D++ DL + +++Q+++ Q E ++T
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 1474 AALPLEPASKEL----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELA 1529
A+ P + A + + ER L + +ER +LL ++ E+ + D D+
Sbjct: 1189 AS-PWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKE 1247
Query: 1530 WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEA 1589
W++E+ G+ L +VQ +K++G R++ A G ++ + E A L A
Sbjct: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA 1307
Query: 1590 EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649
E ++ +L AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++
Sbjct: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
Query: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLY 1709
KD LL++H + ++ + + + LL GH S +I ++ +D+
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
Query: 1710 VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKF 1769
L++ +RR+ L+Q L R + E+W+A +E + + G + V L +K
Sbjct: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
Query: 1770 SEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL 1829
+F + E++AA+ D+LI GH A ++ ++ + + W L M +
Sbjct: 1488 EDFDKAINVQ-EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
Query: 1830 LAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ---RTLRAFEHDLQL 1886
L S+ L +F D E++ I EK + T E +++Q + +AFE +L
Sbjct: 1547 LGESQTLQQFSRDVDEIEAWISEKLQ-----TASDESYKDPTNIQSKHQKHQAFEAELHA 1601
Query: 1887 LVSQVRQLQEGAAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA 1944
++R + + L R AG +A+ +R + W+ L+ + +
Sbjct: 1602 NADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEANKQ 1660
Query: 1945 LRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQEL 2004
F++ ++D W+ + + + + D +D++SV L+ HQ L+ ++ A L
Sbjct: 1661 QNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQ 1720
Query: 2005 GRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWL 2064
SL+ + + +++ + D + R +++ L + +HQF ++ ++W+
Sbjct: 1721 ADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWI 1780
Query: 2065 TAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWE 2101
++ L+ S + G + V+ L ++H+ AA E
Sbjct: 1781 KEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1817
Score = 276 bits (706), Expect = 2e-73
Identities = 203/840 (24%), Positives = 389/840 (46%), Gaps = 15/840 (1%)
Query: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333
E QE ++L++ + + QKL D Q F RD EL+ WI EK+ +A D
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY 72
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
+D L + +HQAF AE+ N + K++ G ++ E + ++R +L E+ + W
Sbjct: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 1453
L + K +L +A K Q ++ ++ + E+ + + G DL V KK +
Sbjct: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
Query: 1454 SMESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLL 1512
++ + V E+ A L E +EL+ +Q+ V RL +R+ L
Sbjct: 193 EFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLF 252
Query: 1513 ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLE 1572
+ E+ + D+D+ ++W++E+ L + G L +VQ ++K++GL R++ A +++
Sbjct: 253 GAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
Query: 1573 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 1632
+ A L A ++ E+L + W +R A R L+ +++++++ D +
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
Query: 1633 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 1692
+ +W+ E + L+ +++ D LL +H + + ++ +E+S +ALL GH
Sbjct: 373 LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
Query: 1693 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 1752
S+++ + + + AL EL E RR EQ L R ++++W++++E +
Sbjct: 433 YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
Query: 1753 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 1812
+LG + V L +K +F A E++ A+++ +LI+ H A +A +D L
Sbjct: 493 EDLGDSLDSVEALLKKHEDFEKSLS-AQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
Query: 1813 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 1872
L E R LA S L +FF D+ EL+ + EK + T E S+
Sbjct: 552 LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-----TATDEAYKDPSN 606
Query: 1873 MQRTL---RAFEHDLQLLVSQVRQLQEGAAQLRTV--YAGEHAEAIASREQEVLQGWKEL 1927
+Q + +AFE +L S++ L++ +L V YA + +A+R EV+ WK+L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA---KDEVAARMNEVISLWKKL 663
Query: 1928 LSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGL 1987
L A E + + +F+ V D+ W+ + + + D +D+++V+ L H L
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 1988 KTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQM 2047
+ ++ A + R A+ I+ + + L R E + E + L
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
Query: 2048 LEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
L + Q ++ + W+ +EP+ S G + V+ L+++H+A + A E R ++
Sbjct: 784 LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
Score = 268 bits (684), Expect = 7e-71
Identities = 283/1183 (23%), Positives = 497/1183 (42%), Gaps = 66/1183 (5%)
Query: 954 SSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAV--- 1010
++++++ + + R++R EL R++++ + + E+ ++EK +
Sbjct: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDE 70
Query: 1011 --ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGA 1068
+ G LQ + EA +QA L E L+ + + EL
Sbjct: 71 NYKDPTNLQGKLQ-KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
Query: 1069 EWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADAL 1128
+W L + G + A +L ++L + + +DW + +EA SE L LE + L
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW-INDKEAIVTSE-ELGQDLEHVEVL 187
Query: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLW 1188
+ + ++ EE + + L+ E + + W +L GL
Sbjct: 188 QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE---LIKTKQDEVNAAWQRLKGLA 244
Query: 1189 EARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTM 1248
R+ L A Q F RD+ + + ++ +E ++ + + SV+ L++H +
Sbjct: 245 LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDL 304
Query: 1249 ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ 1308
+ K++ A+ L + + Q Q L+ ++ + A + +L+D LQ
Sbjct: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
Query: 1309 HFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREG 1367
FL D +L W+ E K L+ D D RHQ E+ +++ + + G
Sbjct: 365 RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
Query: 1368 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL 1427
Q L+ + VR+KL + + A L + + +Q + + ++D +
Sbjct: 425 QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
Query: 1428 HMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELV 1486
E+ L + D G L +V + LKK + E + ++ L + T + + E V
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
Query: 1487 GERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 1546
R++A+ R L E RR L S L Q D D+ +WV E++ A E
Sbjct: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKD 603
Query: 1547 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAVRRGLEQLQSAWAG 1605
+Q ++K+Q E+ A+ R++ LE+AG L + + V + ++ S W
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRID-ALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
Query: 1606 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 1665
L EA E + L A Q +Q+ +V ++E WL E E + S+D GKD + L KKH
Sbjct: 663 LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
Query: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 1725
LE V +++ I ++ Q R + GH D+E I ++Q + Y ALKE R+ L
Sbjct: 723 LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
Query: 1726 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE-RL 1784
L QL R V + E WI EKE +A S G+D V L +K +E +AG E R+
Sbjct: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAE--IAGHEPRI 840
Query: 1785 AAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 1844
AV Q + ++E GH AA + LN+ W L R Q L S + ++F+DA
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 1845 ELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV 1904
E + + EK + T + SA ++ + A DL S ++ L+E A R
Sbjct: 901 EAESWMREKEP-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
Query: 1905 YAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQ 1964
+ +A + E KEL+ A D + R++ I +
Sbjct: 958 ------QQVAPTDDET---GKELVLALYDYQ------------EKSPREVTMKKGDILTL 996
Query: 1965 IGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLD 2024
+ + +K D VEV N QG A V +L Q R LL + Q Q+D
Sbjct: 997 LNSTNK--DWWKVEV--NDRQGFVPA--AYVKKLDPAQSASRENLLEEQGSIALRQEQID 1050
Query: 2025 K----------LGTRKEEVSEKW-------DRHWEWLQQMLEVHQFAQEAVVADAWLTAQ 2067
+ R ++V E + ++ L++ + +EA W+ +
Sbjct: 1051 NQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEK 1110
Query: 2068 EPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRL 2110
E L S E+G+ +++VE L ++ + F+K A E R + ++
Sbjct: 1111 EAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKV 1153
Score = 223 bits (569), Expect = 1e-57
Identities = 149/527 (28%), Positives = 262/527 (49%), Gaps = 10/527 (1%)
Query: 1589 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 1648
AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70
Query: 1649 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
KD + L+KH E V+ +I +L ++ GH SE I R ++ R
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
+ L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 1769 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 1828
F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R
Sbjct: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 1829 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 1885
L + E+ +F D E I+EK + L + +S+Q LR E DL
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQ----LMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 1886 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 1945
L +V+ L A +L+ + A I + +E++ W+++ + + ++ +
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
Query: 1946 RFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELG 2005
RF + RDL SW+ + + I A + DV+ E L++ HQ K E++A + E G
Sbjct: 365 RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
Query: 2006 RSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLT 2065
++LL +DE++ +L L + + E W+ + +Q +++ F ++ D W++
Sbjct: 425 QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
Query: 2066 AQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
QE L + +LG S+D VE L+++HE F K+ +A EE+ ++L T
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
Score = 41.6 bits (96), Expect = 0.010
Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 9/142 (6%)
Query: 399 IDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQ---- 454
+++ W L+K ERE L+ E RQE+ + L Q F W+ E + +
Sbjct: 2175 LEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCM 2234
Query: 455 -DNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSV 513
+ G +EA +KH+ +I A +++ + +L A+ D + +
Sbjct: 2235 VEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGL 2290
Query: 514 LRQWALLTGLVGARRTRLEQNL 535
+QW L L + LEQ +
Sbjct: 2291 AQQWDQLDQLGMRMQHNLEQQI 2312
Score = 35.8 bits (81), Expect = 0.56
Identities = 62/333 (18%), Positives = 126/333 (37%), Gaps = 27/333 (8%)
Query: 285 SKMKALAVEGKRIGKVLDQ---VLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSL 341
SKMK L + + K Q L+ ++ A + +WI + + L
Sbjct: 1949 SKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDL 2008
Query: 342 SGVQQQLQAFTAYCTLEKPVK-FQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDID 400
S VQ L T T + ++ FQ++G + +++ +L A E +
Sbjct: 2009 SSVQTLL---TKQETFDAGLQAFQQEGIANIT--ALKDQLLAAKHVQSKAIEARHA-SLM 2062
Query: 401 KAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYE 460
K W +L R+ L K+E L F K + SW + ++
Sbjct: 2063 KRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNS 2122
Query: 461 LPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALL 520
L ++A + H+A + +++ + +AEL + + + +++ W L
Sbjct: 2123 LEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL 2182
Query: 521 TGLVGAR-------RTRLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADD 572
++ R + R E+N L++ F Q W++E + LL C
Sbjct: 2183 QKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSC--------- 2233
Query: 573 LLQKHGLLEGDIAAQSERVEALNAAALRFSQLQ 605
++++ G LE + A + + + A + +++
Sbjct: 2234 MVEESGTLESQLEATKRKHQEIRAMRSQLKKIE 2266
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 433 bits (1114), Expect = e-121
Identities = 356/1412 (25%), Positives = 621/1412 (43%), Gaps = 102/1412 (7%)
Query: 744 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGH 803
+ ER R+ R +E + R ++L+++ F D + L W+++ ++A+ ++
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
Query: 804 DEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVA--------LQVR 855
D + + ++H+A EV+A+ G + L G L+++ ++ R
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDE----------TGNLMISEGHFASETIRTR 123
Query: 856 VVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDD 915
++E + + + E + L A + + E WI +KE + S + L+
Sbjct: 124 LMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEH 183
Query: 916 VEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVEL 975
VEV+Q +FE +M + RV +VN +L++ HP + +++ QD +N+ W R+ L
Sbjct: 184 VEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGL 243
Query: 976 VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAP-----RAGGALQWRLSGLEAA 1030
QR+ ++ V+ +V E + ++EK + + S + AL + GLE
Sbjct: 244 ALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERD 303
Query: 1031 LQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL 1090
L ALE + AL EA L + P A ++ EEL W + + A + + RL
Sbjct: 304 LAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRL 363
Query: 1091 QRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIV 1150
QRFL D W+ + E L + + A+ALL RH K E+D E+ +
Sbjct: 364 QRFLADFRDLTSWVTEMKALINADE--LASDVAGAEALLDRHQEHKGEIDAHEDSFKSAD 421
Query: 1151 AASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQ 1210
+ +ALLAA + E L L LL LWE RR+ Q QLF RD Q
Sbjct: 422 ESGQALLAAGHYASDE---VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQ 478
Query: 1211 ALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGN 1270
+ QE L +L +++SVE LK+H DF ++ ++K+ + A L++ +
Sbjct: 479 VDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNH 538
Query: 1271 IYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARD 1330
E LL + RA + +L D LQ F RD EL W++EKM A D
Sbjct: 539 YAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD 598
Query: 1331 GTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
+D L + +HQAF AEL+ N+ ++ +E+ GQ+L+ V ++ E+
Sbjct: 599 EAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVIS 658
Query: 1391 CWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK 1450
W +L T+ K +L EA++ Q ++ +++ L +E L D G DL V + K
Sbjct: 659 LWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQK 718
Query: 1451 KLQSMESQVEEWYREVGELQAQTAALPLEPASK---ELVGERQNAVGERLVRLLEPLQER 1507
K +E+ V + + Q A + A E + ++Q A+ R L EP+ R
Sbjct: 719 KHALLEADVAAHQDRIDGITIQ--ARQFQDAGHFDAENIKKKQEALVARYEALKEPMVAR 776
Query: 1508 RRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH 1567
++ L S L Q+ D++DE W++E+ P+A T RG L VQ +KK+Q L+ EI H
Sbjct: 777 KQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGH 836
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
PR++ V ++ A+ AE V+ L +L W L+ A +R+Q L+ + Q +QY+
Sbjct: 837 EPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYF 896
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D E E+W+ E+E ++ S D GKDE S LLKKH L + Y SI L Q ++
Sbjct: 897 ADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSC 956
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLYQLSR--------QVS 1737
+ P ++ + L +AL + E+ R V +++ L L+ +V+
Sbjct: 957 RQQVAPTDDETGK------ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVN 1010
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
+ + ++ V P Q ++L+E+ S +A + +D
Sbjct: 1011 DRQGFVPAAYVKKLDP--AQSASRENLLEEQGS-------------IALRQEQIDNQTRI 1055
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
A + K + E + LLEL R +L S + F +A ELQ I EK L
Sbjct: 1056 TKEAGSVSLRMKQ-VEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAAL 1114
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV-YAGEHAEAIASR 1916
+ +Q+ F+ DL+ S+++ + + A L + E +A+ +
Sbjct: 1115 TSEEVGAD-LEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQ 1173
Query: 1917 E----------------------------------QEVLQGWKELLSACEDARLHVSSTA 1942
E +E+ + W+ L E+ + S
Sbjct: 1174 EVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAH 1233
Query: 1943 DALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQ 2002
+ RFH + W++ + + D++SV+ L H+G + +L A ++ +
Sbjct: 1234 EVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLG 1293
Query: 2003 ELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA 2062
E L+ + A+++Q + +L + ++ D+ L ++ +F + +
Sbjct: 1294 ETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMS 1353
Query: 2063 WLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094
W+ L+ S EL V E L+ RH+ R
Sbjct: 1354 WINGIRGLVSSDELAKDVTGAEALLERHQEHR 1385
Score = 413 bits (1062), Expect = e-114
Identities = 421/1813 (23%), Positives = 768/1813 (42%), Gaps = 177/1813 (9%)
Query: 320 ELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP-VKFQEKGNLEVLLFSI 376
EL +W++ + +++ + + +L G Q+ QAF A + + + EK +++ +
Sbjct: 584 ELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNH 643
Query: 377 QSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDH 436
+K R + ++ W +L +A + LR E +Q Q+F+
Sbjct: 644 YAKDEVAAR----------MNEVISLWKKLLEATELKGIKLR-EANQQ-------QQFNR 685
Query: 437 KVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALA 496
V E WL E + ++ D++G +L V+ KKH +EAD+AA+++R+ G+ A+
Sbjct: 686 NVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQ 745
Query: 497 AEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQA 556
G++D + ++++++ ++ L + AR+ +L +L LQ++F+++ W+ E +
Sbjct: 746 DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEP 805
Query: 557 QLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVIC 616
S G+ L+ +LL+KH L+ +IA R++A+ + + D +
Sbjct: 806 IAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKL 865
Query: 617 NRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAA 676
+ +N L + +A++RR +LE S + EAESW R+KE ++
Sbjct: 866 HELNQKWEAL---KAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIV--------- 913
Query: 677 GAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGA 736
G+ D S LL +H+ L +L A G ++
Sbjct: 914 ------GSTDYGKDEDSAEALLKKHEALMS-----------------DLSAYGSSIQ--- 947
Query: 737 DTVHLVGLAERAASARRRWQRLEEAAARR------ERRLQEARALHQFGADLDGLLDWL- 789
L E+A S R++ ++ + + + + R + D+ LL+
Sbjct: 948 ------ALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTN 1001
Query: 790 RDAYRLAAAGDFGHDEASS-RRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848
+D +++ G A+ ++L A + +G ++ + Q+ +
Sbjct: 1002 KDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGS 1061
Query: 849 VVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMR 908
V +R+ + E+L+ + E+ R+ L + + +F E + + WI EKE L S
Sbjct: 1062 V---SLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEE 1118
Query: 909 VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDH---- 964
V L+ VEV+Q +F+ +++ + R+ D+N ++L G ++EV++ Q
Sbjct: 1119 VGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGL-MAEEVQAVQQQEVYG 1177
Query: 965 ---------------------------------LNSRWNRIVELVEQRKEEMSAVLLVEN 991
LN RW + +L E+R + + + V+
Sbjct: 1178 MMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQR 1237
Query: 992 HVLEVAEVRAQVREKRRAVESAPRAGG-----ALQWRLSGLEAALQALEPRQAALLEEAA 1046
+ E + + EK +A+ + ALQ + G E L AL + +L E A
Sbjct: 1238 FHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAE 1297
Query: 1047 LLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVR 1106
L + P A L + EL W +L A + + LQRFL D + W+
Sbjct: 1298 RLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWING 1357
Query: 1107 AQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGP 1166
+ E L + A+ALL RH + E+D R + + LLA G P
Sbjct: 1358 IRGLVSSDE--LAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA-HGHYASP 1414
Query: 1167 GLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAE 1226
+ + L L+ L W RR L Q QLF RD QA + +E L+ +
Sbjct: 1415 --EIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED 1472
Query: 1227 LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEK 1286
+++SVE +K+H DF + + ++K+ A+ L+ G+ +L++
Sbjct: 1473 KGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDR 1532
Query: 1287 NQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDN-----HKLHK 1341
+ + + + KL + LQ F RD E++ WI EK+ A D + +D KL
Sbjct: 1533 WRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLS 1592
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS---VRKKLGEIRQCWAELEST 1398
+ +HQAF AEL N + + + G L+ E+ A S V+ +L + W L
Sbjct: 1593 KHQKHQAFEAELHANADRIRGVIDMGNSLI-ERGACAGSEDAVKARLAALADQWQFLVQK 1651
Query: 1399 TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQ 1458
+ K+++L EA+K + D L +E+ L D G DLA+VN+ LKK Q +E+
Sbjct: 1652 SAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEAD 1711
Query: 1459 VEEWYREVGELQAQTAALPLEPA-SKELVGERQNAVGERLVRLLEPLQERRRLLLASKEL 1517
+ + +L +Q +L A V ++++ + R ++ RR L S L
Sbjct: 1712 ISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRL 1771
Query: 1518 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 1577
HQ D+DDE +W++E+ L + G L VQ KK++ L E+ AH P ++ VL+
Sbjct: 1772 HQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDT 1831
Query: 1578 AGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L+ + E +++ L Q W L++ A R Q L+ + + +Q+ +V E EAW+
Sbjct: 1832 GKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWI 1891
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E+ L+ SED G + LLKKH E +++ + + + L++ + E
Sbjct: 1892 NEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEEN 1951
Query: 1698 ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 1757
IS + ++ L++ +R+ L++ Q + + +E WI EKE + + G+
Sbjct: 1952 ISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGR 2011
Query: 1758 DFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWA 1817
D V L K F + +E +A + + D+L+ H + + L + W+
Sbjct: 2012 DLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWS 2071
Query: 1818 ELLELMGTR-AQLLAASRELHK-------FFSDARELQGQIEEKRR------RLPRLTTP 1863
+LL R +LL A K F A E R L
Sbjct: 2072 QLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEI 2131
Query: 1864 PEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ--EGAAQLRTVYAGEHAEAIASREQEV- 1920
R + + + +L + + D L RQ++ A+ T + E E Q++
Sbjct: 2132 KALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKII 2191
Query: 1921 ----LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSW-MDG--IASQIGAADKPRD 1973
L+ KE E+ +L A FH +++ ++ +DG + + G +
Sbjct: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLE---- 2247
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRS-----LLLNKSAMADEIQA-----QL 2023
S +E HQ E+ A +L ++LG + +L NK + QL
Sbjct: 2248 -SQLEATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQL 2302
Query: 2024 DKLGTRKEEVSEK 2036
D+LG R + E+
Sbjct: 2303 DQLGMRMQHNLEQ 2315
Score = 370 bits (949), Expect = e-101
Identities = 402/1874 (21%), Positives = 768/1874 (40%), Gaps = 152/1874 (8%)
Query: 311 IERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEKGNLE 370
++R+ +L +W+ LI+ + A+ ++G + L + KG ++
Sbjct: 363 LQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEID 411
Query: 371 VLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLE-- 428
S +S + L G + D+ +L ER A L +R+++ E
Sbjct: 412 AHEDSFKSADESGQALL-----AAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQC 466
Query: 429 LLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGV 488
+ Q F ++W+++ + + ++ G L +VEA +KKHE E ++A EE++ +
Sbjct: 467 MDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL 526
Query: 489 AELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMV 548
E A L +Y + VA +RD++L + L RR +L + LQ+ F++ +
Sbjct: 527 DEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELK 586
Query: 549 DWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQ 608
W+ E + + + E + +QKH E +++A R++AL A + + Y
Sbjct: 587 SWVNE-KMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA 645
Query: 609 PCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLE 668
+ + R+N V +L E + +L + + +E+ E W + E L
Sbjct: 646 KDE---VAARMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLA 702
Query: 669 AAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAA 728
+ G DL++ L +H +L+ ++ + + + A
Sbjct: 703 SDDYG---------------KDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDA 747
Query: 729 GGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDW 788
G + ++ + R++ L+E R+++L ++ L Q D++ W
Sbjct: 748 GH--------FDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETW 799
Query: 789 LRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPL 848
+R+ +AA+ + G D + L ++H+AL E+ H + + ++ G A
Sbjct: 800 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK----GNAMVEEGH 855
Query: 849 VVA--LQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906
A ++ ++ E Q + + A+ RRQ L D+L + F + + E W+ EKE + S
Sbjct: 856 FAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGS 915
Query: 907 MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966
D E + + E+L ++++ + + Q + P+ DE
Sbjct: 916 TDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGK------ 969
Query: 967 SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEV------RAQVREKRRAVESA------P 1014
++ L + +++ V + + +L + + +V +++ V +A P
Sbjct: 970 ---ELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDP 1026
Query: 1015 RAGGALQWRLS--GLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGA 1072
+ + L G A Q Q + +EA ++ R Q L+ ELG +
Sbjct: 1027 AQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMK-QVEELYHSLLELGEKRKG 1085
Query: 1073 LASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP--LPNSLEEADALLA 1130
+ + A LQ+++++ +A L ++E E L ++ L
Sbjct: 1086 MLEKSCKKFMLFREANELQQWINEKEAALT----SEEVGADLEQVEVLQKKFDDFQKDLK 1141
Query: 1131 RHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDE--------W--------- 1173
+ + +++++ ED +E + A E+ + DE W
Sbjct: 1142 ANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHT 1201
Query: 1174 ------LPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAEL 1227
+ L W L L E R + L AH Q F RD + + + AL+
Sbjct: 1202 VATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNY 1261
Query: 1228 PGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKN 1287
+ SV+ ++H F + K+ + AE L++ E QE T L +
Sbjct: 1262 GHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAW 1321
Query: 1288 QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRH 1346
RA Q KL D +LQ FL D +L WI+ + L++ D +D RH
Sbjct: 1322 SSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERH 1381
Query: 1347 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 1406
Q E+ + E+ GQQL+ + +++KL + Q A+LE + L
Sbjct: 1382 QEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMML 1441
Query: 1407 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 1466
+ + + + + + E+ L D G L +V + +KK + + + ++
Sbjct: 1442 DQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKI 1501
Query: 1467 GELQAQTAAL-PLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 1525
LQA L +K + R+N V +R RL + E+R L S+ L Q + D+D
Sbjct: 1502 AALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVD 1561
Query: 1526 DELAWVQERLPLAMQTERGNG----LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGAL 1581
+ AW+ E+L A + L + +K+Q E+ A+ R+ V++ +L
Sbjct: 1562 EIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSL 1621
Query: 1582 ASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 1639
+ +AV+ L L W L + + + Q L A + + + + + + WL E
Sbjct: 1622 IERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSE 1681
Query: 1640 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQIS 1699
E L+ SED GKD S LLKKH LE + +E+ + L+ Q +L+ D+ Q+
Sbjct: 1682 VEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVK 1741
Query: 1700 RRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDF 1759
++ ++ + +K + RR L + + L+Q R + + E WI EK+++ GS + G+D
Sbjct: 1742 DKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDL 1801
Query: 1760 EHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN------ 1813
V L++K +E LAA + +++ G + K+ +
Sbjct: 1802 TGVQNLRKKHKRLEAE--------LAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQF 1853
Query: 1814 -EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 1872
E W EL +L R Q L S E +F ++ E + I EK L + + ++
Sbjct: 1854 VEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT----LVASEDYGDTLAA 1909
Query: 1873 MQRTLR---AFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW-KELL 1928
+Q L+ AFE D + +V + L + H E S + + L G +L
Sbjct: 1910 IQGLLKKHEAFETDFTVHKDRVNDVCTNGQDL--IKKNNHHEENISSKMKGLNGKVSDLE 1967
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
A + + + L+F+ + + SW+ + + D RD+SSV+ L+ +
Sbjct: 1968 KAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFD 2027
Query: 1989 TELEARVPE-LTTCQELGRSLLLNKSAMADEIQAQ-----------LDKLGTRKEEVSEK 2036
L+A E + L LL K + I+A+ L RK+++ E
Sbjct: 2028 AGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEA 2087
Query: 2037 WDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKA 2096
H+ ++ + FA++A ++W E L +S++E++ L H+AFR +
Sbjct: 2088 -QSHFRKVEDLFLT--FAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSS 2144
Query: 2097 AAAWEERFSSLRRL 2110
++ + F+ L L
Sbjct: 2145 LSSAQADFNQLAEL 2158
Score = 348 bits (894), Expect = 3e-95
Identities = 405/1900 (21%), Positives = 791/1900 (41%), Gaps = 134/1900 (7%)
Query: 258 LDPEDVNM--EAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLEVGKIIERYE 315
+DP V + A D + V+ YH F ++ L Q LE + ++
Sbjct: 1 MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLR----------RQKLEDSYRFQFFQ 50
Query: 316 ELAAELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP--VKFQEKGNLEV 371
A EL WI + + S++ + + +L G Q+ QAF A VK E GNL +
Sbjct: 51 RDAEELEKWIQEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI 110
Query: 372 LLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEKLELLA 431
S+ RL ++ + W L E RE ++ L++ +KL
Sbjct: 111 SEGHFASE--TIRTRLM---------ELHRQWELL--LEKMREKGIK--LLQAQKLVQYL 155
Query: 432 QRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAEL 491
+ + + W+N+ + +V+ + G +L VE KK E + D+AA+EERV V +
Sbjct: 156 RECEDVM----DWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQF 211
Query: 492 AQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWM 551
A L E + + + ++D V W L GL R+ +L +Q+ +++ + W+
Sbjct: 212 AAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWI 271
Query: 552 EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCD 611
+E + + S + G+ L LL+KH LE D+AA ++V+AL A A +LQ P
Sbjct: 272 KEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEA---DRLQQSHPLS 328
Query: 612 PQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAG 671
I + + +++ AA R A L S L L + + SW + + L+ A
Sbjct: 329 ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINA-- 386
Query: 672 GGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGA 731
A D++ LL +H+ +GE+ + A G+ L+AAG
Sbjct: 387 -------------DELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHY 433
Query: 732 VGPGADTVH--LVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWL 789
+D V L L+E A+ W+ R ++ ++ L F D + + +W+
Sbjct: 434 ---ASDEVREKLTVLSEERAALLELWE-------LRRQQYEQCMDLQLFYRDTEQVDNWM 483
Query: 790 RDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLV 849
D G S L ++H + A ++ L L +
Sbjct: 484 SKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMED 543
Query: 850 VALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRV 909
VA + + + + + E A RR L D+ + + F + + W+ EK +
Sbjct: 544 VATRRDALLSRR--NALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAY 601
Query: 910 PDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRW 969
D + VQ + ++ + E+++ R+ + Q+L++ H + DEV + + + S W
Sbjct: 602 KDPSNLQGKVQ-KHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW 660
Query: 970 NRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGA-----LQWRL 1024
+++E E + ++ + V ++ + E + S LQ +
Sbjct: 661 KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Query: 1025 SGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAV 1084
+ LEA + A + R + +A + A + + E L A + AL A + +
Sbjct: 721 ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL 780
Query: 1085 AAAGRLQRFLHDLDAFLDWLVRAQE--AAGGSEGPLPNSLEEADALLARHAALKEEVDQR 1142
A + RLQ+ D++ W +R +E AA + G L LL +H AL+ E+
Sbjct: 781 ADSLRLQQLFRDVEDEETW-IREKEPIAASTNRG---KDLIGVQNLLKKHQALQAEIAGH 836
Query: 1143 EEDYARIVAASEALLAADGAELGPGLALD--EWLPHLELGWHKLLGLWEARREALVQAHI 1200
E + A++ E G A D L L W L RR+ L +
Sbjct: 837 EPRIKAVTQKGNAMV-----EEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
Q + D +A +R +E + + +S E LK+H ++ + +Q +
Sbjct: 892 AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
Query: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLR------DC 1314
A+ +Q ++ + + L QE R + K D L L + +
Sbjct: 952 QAQSCRQQVAPTDDETGKELVLALYDYQEKSPR--EVTMKKGDILTLLNSTNKDWWKVEV 1009
Query: 1315 HELDGWIH----EKMLMARDGTRED------NHKLHKRWLRHQAFMAELAQNKEW-LEKI 1363
++ G++ +K+ A+ +RE+ + L + + +Q + + A + ++++
Sbjct: 1010 NDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQV 1069
Query: 1364 EREGQQLMQ----EKPELAASVRK-----KLGEIRQCWAELESTTQAKARQLFEASKADQ 1414
E L++ K L S +K + E++Q W + + + +
Sbjct: 1070 EELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQ-WINEKEAALTSEEVGADLEQVEV 1128
Query: 1415 LVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQSMESQVEEWYREVGELQAQT 1473
L + F + K L ES+L+D++ DL + +++Q+++ Q E ++T
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 1474 AALPLEPASKEL----VGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELA 1529
A+ P + A + + ER L + +ER +LL ++ E+ + D D+
Sbjct: 1189 AS-PWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKE 1247
Query: 1530 WVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEA 1589
W++E+ G+ L +VQ +K++G R++ A G ++ + E A L A
Sbjct: 1248 WIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESA 1307
Query: 1590 EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649
E ++ +L AW+ L + A++R+ L + ++++ D ++ +W+ L+ S++
Sbjct: 1308 EDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDEL 1367
Query: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLY 1709
KD LL++H + ++ + + + LL GH S +I ++ +D+
Sbjct: 1368 AKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQER 1427
Query: 1710 VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKF 1769
L++ +RR+ L+Q L R + E+W+A +E + + G + V L +K
Sbjct: 1428 ADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
Query: 1770 SEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL 1829
+F + E++AA+ D+LI GH A ++ ++ + + W L M +
Sbjct: 1488 EDFDKAINVQ-EEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSK 1546
Query: 1830 LAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL------RAFEHD 1883
L S+ L +F D E++ I EK L + P+ + + L +AFE +
Sbjct: 1547 LGESQTLQQFSRDVDEIEAWISEK---LQTASDESYKDPTNIQLSKLLSKHQKHQAFEAE 1603
Query: 1884 LQLLVSQVRQLQEGAAQL--RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSST 1941
L ++R + + L R AG +A+ +R + W+ L+ + +
Sbjct: 1604 LHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQKSAEKSQKLKEA 1662
Query: 1942 ADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTC 2001
F++ ++D W+ + + + + D +D++SV L+ HQ L+ ++ A L
Sbjct: 1663 NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1722
Query: 2002 QELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVAD 2061
SL+ + + +++ + D + R +++ L + +HQF ++ +
Sbjct: 1723 NSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEE 1782
Query: 2062 AWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWE 2101
+W+ ++ L+ S + G + V+ L ++H+ AA E
Sbjct: 1783 SWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHE 1822
Score = 276 bits (706), Expect = 2e-73
Identities = 203/840 (24%), Positives = 389/840 (46%), Gaps = 15/840 (1%)
Query: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333
E QE ++L++ + + QKL D Q F RD EL+ WI EK+ +A D
Sbjct: 13 EDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY 72
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
+D L + +HQAF AE+ N + K++ G ++ E + ++R +L E+ + W
Sbjct: 73 KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWE 132
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 1453
L + K +L +A K Q ++ ++ + E+ + + G DL V KK +
Sbjct: 133 LLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFE 192
Query: 1454 SMESQVEEWYREVGELQAQTAALPLEP-ASKELVGERQNAVGERLVRLLEPLQERRRLLL 1512
++ + V E+ A L E +EL+ +Q+ V RL +R+ L
Sbjct: 193 EFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLF 252
Query: 1513 ASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLE 1572
+ E+ + D+D+ ++W++E+ L + G L +VQ ++K++GL R++ A +++
Sbjct: 253 GAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVK 312
Query: 1573 EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAE 1632
+ A L A ++ E+L + W +R A R L+ +++++++ D +
Sbjct: 313 ALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRD 372
Query: 1633 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 1692
+ +W+ E + L+ +++ D LL +H + + ++ +E+S +ALL GH
Sbjct: 373 LTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
Query: 1693 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 1752
S+++ + + + AL EL E RR EQ L R ++++W++++E +
Sbjct: 433 YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
Query: 1753 PELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGL 1812
+LG + V L +K +F A E++ A+++ +LI+ H A +A +D L
Sbjct: 493 EDLGDSLDSVEALLKKHEDFEKSLS-AQEEKITALDEFATKLIQNNHYAMEDVATRRDAL 551
Query: 1813 NEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS 1872
L E R LA S L +FF D+ EL+ + EK + T E S+
Sbjct: 552 LSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMK-----TATDEAYKDPSN 606
Query: 1873 MQRTL---RAFEHDLQLLVSQVRQLQEGAAQLRTV--YAGEHAEAIASREQEVLQGWKEL 1927
+Q + +AFE +L S++ L++ +L V YA + +A+R EV+ WK+L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYA---KDEVAARMNEVISLWKKL 663
Query: 1928 LSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGL 1987
L A E + + +F+ V D+ W+ + + + D +D+++V+ L H L
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 1988 KTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQM 2047
+ ++ A + R A+ I+ + + L R E + E + L
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
Query: 2048 LEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
L + Q ++ + W+ +EP+ S G + V+ L+++H+A + A E R ++
Sbjct: 784 LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
Score = 268 bits (684), Expect = 7e-71
Identities = 283/1183 (23%), Positives = 497/1183 (42%), Gaps = 66/1183 (5%)
Query: 954 SSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAV--- 1010
++++++ + + R++R EL R++++ + + E+ ++EK +
Sbjct: 11 TAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDE 70
Query: 1011 --ESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGA 1068
+ G LQ + EA +QA L E L+ + + EL
Sbjct: 71 NYKDPTNLQGKLQ-KHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHR 129
Query: 1069 EWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADAL 1128
+W L + G + A +L ++L + + +DW + +EA SE L LE + L
Sbjct: 130 QWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDW-INDKEAIVTSE-ELGQDLEHVEVL 187
Query: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLW 1188
+ + ++ EE + + L+ E + + W +L GL
Sbjct: 188 QKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEE---LIKTKQDEVNAAWQRLKGLA 244
Query: 1189 EARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTM 1248
R+ L A Q F RD+ + + ++ +E ++ + + SV+ L++H +
Sbjct: 245 LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDL 304
Query: 1249 ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ 1308
+ K++ A+ L + + Q Q L+ ++ + A + +L+D LQ
Sbjct: 305 AALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
Query: 1309 HFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREG 1367
FL D +L W+ E K L+ D D RHQ E+ +++ + + G
Sbjct: 365 RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
Query: 1368 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLL 1427
Q L+ + VR+KL + + A L + + +Q + + ++D +
Sbjct: 425 QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
Query: 1428 HMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGEL-QAQTAALPLEPASKELV 1486
E+ L + D G L +V + LKK + E + ++ L + T + + E V
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDV 544
Query: 1487 GERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNG 1546
R++A+ R L E RR L S L Q D D+ +WV E++ A E
Sbjct: 545 ATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATD-EAYKD 603
Query: 1547 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGA-LASLRSPEAEAVRRGLEQLQSAWAG 1605
+Q ++K+Q E+ A+ R++ LE+AG L + + V + ++ S W
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRID-ALEKAGQKLIDVNHYAKDEVAARMNEVISLWKK 662
Query: 1606 LREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ 1665
L EA E + L A Q +Q+ +V ++E WL E E + S+D GKD + L KKH
Sbjct: 663 LLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHAL 722
Query: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQ 1725
LE V +++ I ++ Q R + GH D+E I ++Q + Y ALKE R+ L
Sbjct: 723 LEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLAD 782
Query: 1726 QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRE-RL 1784
L QL R V + E WI EKE +A S G+D V L +K +E +AG E R+
Sbjct: 783 SLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAE--IAGHEPRI 840
Query: 1785 AAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAR 1844
AV Q + ++E GH AA + LN+ W L R Q L S + ++F+DA
Sbjct: 841 KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 1845 ELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTV 1904
E + + EK + T + SA ++ + A DL S ++ L+E A R
Sbjct: 901 EAESWMREKEP-IVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-- 957
Query: 1905 YAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQ 1964
+ +A + E KEL+ A D + R++ I +
Sbjct: 958 ------QQVAPTDDET---GKELVLALYDYQ------------EKSPREVTMKKGDILTL 996
Query: 1965 IGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLD 2024
+ + +K D VEV N QG A V +L Q R LL + Q Q+D
Sbjct: 997 LNSTNK--DWWKVEV--NDRQGFVPA--AYVKKLDPAQSASRENLLEEQGSIALRQEQID 1050
Query: 2025 K----------LGTRKEEVSEKW-------DRHWEWLQQMLEVHQFAQEAVVADAWLTAQ 2067
+ R ++V E + ++ L++ + +EA W+ +
Sbjct: 1051 NQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEK 1110
Query: 2068 EPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRL 2110
E L S E+G+ +++VE L ++ + F+K A E R + ++
Sbjct: 1111 EAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKV 1153
Score = 223 bits (569), Expect = 1e-57
Identities = 149/527 (28%), Positives = 262/527 (49%), Gaps = 10/527 (1%)
Query: 1589 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 1648
AE ++ +Q+ + +E + R+Q L+ +++ + + D E+E W+ +++L + S++
Sbjct: 12 AEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI-QEKLQIASDE 70
Query: 1649 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
KD + L+KH E V+ +I +L ++ GH SE I R ++ R
Sbjct: 71 NYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 130
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
+ L E E+ + L Q L Q R+ ++ WI +KE + S ELGQD EHV VLQ+K
Sbjct: 131 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKK 190
Query: 1769 FSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQ 1828
F EF ++ A ER+ VNQ +LI+ H + +D +N AW L L R
Sbjct: 191 FEEFQTDMA-AHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQG 249
Query: 1829 LLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR---AFEHDLQ 1885
L + E+ +F D E I+EK + L + +S+Q LR E DL
Sbjct: 250 KLFGAAEVQRFNRDVDETISWIKEKEQ----LMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 1886 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 1945
L +V+ L A +L+ + A I + +E++ W+++ + + ++ +
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLS-ATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQ 364
Query: 1946 RFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELG 2005
RF + RDL SW+ + + I A + DV+ E L++ HQ K E++A + E G
Sbjct: 365 RFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESG 424
Query: 2006 RSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLT 2065
++LL +DE++ +L L + + E W+ + +Q +++ F ++ D W++
Sbjct: 425 QALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMS 484
Query: 2066 AQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
QE L + +LG S+D VE L+++HE F K+ +A EE+ ++L T
Sbjct: 485 KQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFAT 531
Score = 41.6 bits (96), Expect = 0.010
Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 9/142 (6%)
Query: 399 IDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQ---- 454
+++ W L+K ERE L+ E RQE+ + L Q F W+ E + +
Sbjct: 2180 LEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCM 2239
Query: 455 -DNFGYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSV 513
+ G +EA +KH+ +I A +++ + +L A+ D + +
Sbjct: 2240 VEESGTLESQLEATKRKHQ----EIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGL 2295
Query: 514 LRQWALLTGLVGARRTRLEQNL 535
+QW L L + LEQ +
Sbjct: 2296 AQQWDQLDQLGMRMQHNLEQQI 2317
Score = 35.8 bits (81), Expect = 0.56
Identities = 62/333 (18%), Positives = 126/333 (37%), Gaps = 27/333 (8%)
Query: 285 SKMKALAVEGKRIGKVLDQ---VLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSL 341
SKMK L + + K Q L+ ++ A + +WI + + L
Sbjct: 1954 SKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDL 2013
Query: 342 SGVQQQLQAFTAYCTLEKPVK-FQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDID 400
S VQ L T T + ++ FQ++G + +++ +L A E +
Sbjct: 2014 SSVQTLL---TKQETFDAGLQAFQQEGIANIT--ALKDQLLAAKHVQSKAIEARHA-SLM 2067
Query: 401 KAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYE 460
K W +L R+ L K+E L F K + SW + ++
Sbjct: 2068 KRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNS 2127
Query: 461 LPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALL 520
L ++A + H+A + +++ + +AEL + + + +++ W L
Sbjct: 2128 LEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNL 2187
Query: 521 TGLVGAR-------RTRLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADD 572
++ R + R E+N L++ F Q W++E + LL C
Sbjct: 2188 QKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSC--------- 2238
Query: 573 LLQKHGLLEGDIAAQSERVEALNAAALRFSQLQ 605
++++ G LE + A + + + A + +++
Sbjct: 2239 MVEESGTLESQLEATKRKHQEIRAMRSQLKKIE 2271
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 409 bits (1051), Expect = e-113
Identities = 243/606 (40%), Positives = 354/606 (58%), Gaps = 32/606 (5%)
Query: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
E Q+KTFT W NSHL + G I ++ D RDG L LLEV+SGE+LP+P RG+MR+H
Sbjct: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
Query: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVE-----ET 163
Query: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
SAK+ LLLWCQ KTA Y VN+QNF SW+DGLAFNALIHRHRP+L+++ KL K +
Sbjct: 164 -SAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVT 222
Query: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
NL AF AE++L + ++LD ED VN PDEK+I+TYV SFYH FS + RI
Sbjct: 223 NLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 282
Query: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
KVL E ++E YE+LA++LL WI RT+ + ++ ++ +QQ+L+ F Y +
Sbjct: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
Query: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
KP K QEK LE+ ++Q+KLR NR F+P EG + DI+ W LE+AE E L
Sbjct: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
Query: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVS-QDNFGYELPAVEAAMKKHEAIEAD 477
E+ R E+L+ LA++F K ++ E+W + + ++ +D L ++A ++KHEA E+D
Sbjct: 403 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
Query: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLE----Q 533
+AA+++RV+ +A +AQ L YYD V + + QW L L +RR LE Q
Sbjct: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQ 522
Query: 534 NLALQKVFQEMVYMV----DWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEG---DIAA 586
A+ ++ E +WME L + E + L+ H + D
Sbjct: 523 LEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADR 582
Query: 587 QSERVEALNAAALRFSQ-----LQG---YQPCDPQVICNRVNHVHGCL-----AELQEQA 633
+ E + A++ A R ++ L G Y PQ+I ++ V + A L+EQ+
Sbjct: 583 EREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQS 642
Query: 634 ARRRAE 639
++ E
Sbjct: 643 KQQSNE 648
Score = 45.4 bits (106), Expect = 7e-04
Identities = 63/294 (21%), Positives = 123/294 (41%), Gaps = 29/294 (9%)
Query: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL- 1886
++LA ++E D +L + E RR P+ + MQ+ L F ++
Sbjct: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
Query: 1887 ---LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE----QEVLQGWKELLSA--------- 1930
V + QL+ L+T + A E ++ GW+ L A
Sbjct: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
Query: 1931 CEDARLH-VSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSSVEVLMNYHQGLK 1988
E RL + A+ R + + + +W DG + + D + +S ++ L+ H+ +
Sbjct: 403 NEIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFE 460
Query: 1989 TELEA---RVPELTT-CQELGRSLLL---NKSAMADEIQAQLDKLGTRKEEVSEKWDRHW 2041
++L A RV ++ QEL N + +I Q D LG+ E ++
Sbjct: 461 SDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTE 520
Query: 2042 EWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094
+ L+ + ++H ++A+ A + W+ + LQ + +++E+E LI H+ F+
Sbjct: 521 KQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFK 574
Score = 42.4 bits (98), Expect = 0.006
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 1849 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE 1908
++ EK +P++ A + T R E + VS GA +
Sbjct: 229 EVAEKYLDIPKML-------DAEDIVNTARPDEKAIMTYVSSFYHAFSGA---------Q 272
Query: 1909 HAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAA 1968
AE A+R +VL +E ED + +D L + +R + W++ Q
Sbjct: 273 KAETAANRICKVLAVNQENEHLMED---YEKLASDLLEW---IRRTIPWLEDRVPQKTIQ 326
Query: 1969 DKPRDVSSVEVLMNYHQGLKTE----LEARVPELTTCQELGR--SLLLNKSAMADEIQAQ 2022
+ + + H+ K + LE L T L + + ++ M +I
Sbjct: 327 EMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNG 386
Query: 2023 LDKLGTRKEEVSEKW----DRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGS 2078
L + E+ E+W R E L + E +F Q+A + +AW +E +L+ R+ +
Sbjct: 387 WQHL-EQAEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLKHRDYET 443
Query: 2079 S-VDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
+ + +++ LIR+HEAF AA ++R +
Sbjct: 444 ATLSDIKALIRKHEAFESDLAAHQDRVEQI 473
Score = 35.4 bits (80), Expect = 0.73
Identities = 59/277 (21%), Positives = 116/277 (41%), Gaps = 18/277 (6%)
Query: 1168 LALDEWLPHLELGWHKL---LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSG 1224
LA+++ HL + KL L W R ++ + Q +++++Q L R+
Sbjct: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
Query: 1225 AELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
+ V+E + +F T + + A +EG + G Q E +
Sbjct: 345 PK-------VQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGY 397
Query: 1285 EKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWL 1344
E+ N++R + + L ++ + + + DG E ML RD +
Sbjct: 398 EEWLLNEIRRLERLDHLAEKFRQKASIHEAWT-DG--KEAMLKHRDYETATLSDIKALIR 454
Query: 1345 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 1404
+H+AF ++LA +++ +E+I Q+L + + +V + +I W L S T ++
Sbjct: 455 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRRE 514
Query: 1405 QLFEASK----ADQLVQSFAELDKKLLH-MESQLQDV 1436
L + K DQL +A+ + MES ++D+
Sbjct: 515 ALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551
Score = 32.0 bits (71), Expect = 8.1
Identities = 37/159 (23%), Positives = 64/159 (40%), Gaps = 16/159 (10%)
Query: 872 LRRQWLRDALAV-YRMFGEVHACELWIGEKEQWLLSMRVPDS-LDDVEVVQHRFESLDQE 929
+RR D LA +R +H E W KE L + L D++ + + E+ + +
Sbjct: 405 IRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
Query: 930 MNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLV 989
+ + RV + QEL E + S V + + +W+ + L R+E
Sbjct: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRRE-------- 514
Query: 990 ENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLE 1028
LE E + + ++ +E A RA W S +E
Sbjct: 515 ---ALEKTEKQLEAIDQLH-LEYAKRAAPFNNWMESAME 549
Score = 32.0 bits (71), Expect = 8.1
Identities = 31/161 (19%), Positives = 71/161 (44%), Gaps = 16/161 (9%)
Query: 1547 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL 1606
L ++ I+K++ ++ AH R+E++ A L L ++ V +++ W L
Sbjct: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDAL 505
Query: 1607 -------REAAERRQQVLDAAFQVE-QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 1658
REA E+ ++ L+A Q+ +Y A W M S + + +
Sbjct: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNW-------MESAMEDLQDMFIVH 558
Query: 1659 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQIS 1699
+++ L + ++ ++ R+ A+L + H ++++I+
Sbjct: 559 TIEEIEGLISAHDQFKSTLPDADREREAILAI-HKEAQRIA 598
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 405 bits (1042), Expect = e-112
Identities = 221/487 (45%), Positives = 310/487 (63%), Gaps = 8/487 (1%)
Query: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
E Q+KTFT W NSHL + G I ++ D RDG L LLEV+SGE+L +P RG+MR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE-----ET 144
Query: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
SAK+ LLLWCQ KTA Y VNIQNF SW+DGL F ALIHRHRP+L+D+ KL K +
Sbjct: 145 -SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
NL AF AE++L + ++LD ED V PDEK+I+TYV SFYH FS + RI
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
KVL E +++E YE+LA++LL WI RT+ + N+ N++ +QQ+L+ F Y L
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
KP K QEK LE+ ++Q+KLR NR F+P EG + DI+ AWG LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF-GYELPAVEAAMKKHEAIEAD 477
E+ R E+L+ LA++F K ++ E+W + + ++ Q ++ L ++A +KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537
+AA+++RV+ +A +AQ L YYD V A+ + QW L L RR LE+ L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 538 QKVFQEM 544
+ ++
Sbjct: 504 LETIDQL 510
Score = 64.3 bits (155), Expect = 1e-09
Identities = 96/486 (19%), Positives = 202/486 (41%), Gaps = 60/486 (12%)
Query: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
++ R+ ++L QE +L+ ++ ++A DL L W++ +P N +
Sbjct: 253 QKAETAANRICKVLAVNQENEQLM---EDYEKLASDL---LEWIRRTIPWLENRVPENTM 306
Query: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR--------RGLEQL 1599
A+QQ ++ + RR + P+++E + +L++ + R R + +
Sbjct: 307 HAMQQKLEDFRDYRRLHKP--PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDI 364
Query: 1600 QSAWAGLREAAE----------RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649
+AW L + + RR + LD E++ + EAW +E ++ +D
Sbjct: 365 NNAWGCLEQVEKGYEEWLLNEIRRLERLDHL--AEKFRQKASIHEAWTDGKEAMLRQKDY 422
Query: 1650 GKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
S ++ LLKKH E + +++ + Q++ + L E+ + DS ++ R ++
Sbjct: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQ 482
Query: 1709 YVALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760
+ L L ++RR ALE+ L + +++ + +W+ + E
Sbjct: 483 WDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIE 542
Query: 1761 HVSVLQEKFSEFASETGMAGRERLA--AVNQMVDELIECGHTAAATMAEW----KDGLNE 1814
+ L +F + A +ERLA ++ V ++++ H A + +N
Sbjct: 543 EIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
Query: 1815 AWAELLELMGTRAQLLAA--SRELH------KFFSDARELQGQIEEKRRRLPRLTTPPEP 1866
W + +L+ R Q L +R+ H +F + A + I+ K + R++ E
Sbjct: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EM 660
Query: 1867 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL---RTVYAGEHAEAIASREQEVLQG 1923
+ LR +E + ++ QL EG QL ++ +H + + G
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQLIQEALIFDNKHTNYTM---EHIRVG 716
Query: 1924 WKELLS 1929
W++LL+
Sbjct: 717 WEQLLT 722
Score = 43.5 bits (101), Expect = 0.003
Identities = 69/318 (21%), Positives = 135/318 (42%), Gaps = 32/318 (10%)
Query: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL- 1886
++LA ++E + D +L + E RR P + +MQ+ L F +L
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 1887 ---LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--------------QEVLQGWKELLS 1929
V + QL+ L+T + A E ++V +G++E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 1930 ACEDARLH-VSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSSVEVLMNYHQGL 1987
E RL + A+ R + + + +W DG + + D + +S ++ L+ H+
Sbjct: 384 N-EIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 1988 KTELEA---RVPELTT-CQELGRSLLLNK---SAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
+++L A RV ++ QEL + +A +I Q D LG ++ E +R
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 2041 WEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA- 2098
+ L+ + +++ ++A+ A + W+ LQ + +++E++ L HE F+
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
Query: 2099 AWEERFSSLRRLTTIEKI 2116
A +ER + L + KI
Sbjct: 561 ADKERLAILGIHNEVSKI 578
Score = 40.0 bits (92), Expect = 0.030
Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 530 RLEQNLALQKVFQEMVYMVD-WMEEMQAQLLSRECGQH-LVEADDLLQKHGLLEGDIAAQ 587
RLE+ L + F++ + + W + +A L ++ L E LL+KH E D+AA
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 588 SERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLW 647
+RVE + A A ++L Y C ++ L L + +RR LE + L
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ---KRREALERTEKLL 504
Query: 648 ALLQEL 653
+ +L
Sbjct: 505 ETIDQL 510
Score = 32.7 bits (73), Expect = 4.7
Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 1323 EKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR 1382
E ML +D ++ +H+AF ++LA +++ +E+I Q+L + + SV
Sbjct: 414 EAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN 473
Query: 1383 KKLGEIRQCWAELESTTQAKARQLFEASK----ADQLVQSFAE 1421
+ +I W L + TQ + L K DQL +A+
Sbjct: 474 ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Score = 32.0 bits (71), Expect = 8.1
Identities = 43/199 (21%), Positives = 77/199 (38%), Gaps = 18/199 (9%)
Query: 1065 ELGAEWGALASAAQACGE-AVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN--- 1120
++ WG L + E + RL+R H + F + G E L
Sbjct: 363 DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDY 422
Query: 1121 ---SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHL 1177
+L E ALL +H A + ++ ++ +I A ++ L D + +++ +
Sbjct: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD---SPSVNARCQKI 479
Query: 1178 ELGWHKLLGLWEARREALVQAH-----IYQLFLRDLRQALVVLRNQEMALSGAE---LPG 1229
W L L + RREAL + I QL+L ++A E A+ + +
Sbjct: 480 CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH 539
Query: 1230 TVESVEEALKQHRDFLTTM 1248
T+E ++ H F T+
Sbjct: 540 TIEEIQGLTTAHEQFKATL 558
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 405 bits (1042), Expect = e-112
Identities = 221/487 (45%), Positives = 310/487 (63%), Gaps = 8/487 (1%)
Query: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
E Q+KTFT W NSHL + G I ++ D RDG L LLEV+SGE+L +P RG+MR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE-----ET 144
Query: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
SAK+ LLLWCQ KTA Y VNIQNF SW+DGL F ALIHRHRP+L+D+ KL K +
Sbjct: 145 -SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
NL AF AE++L + ++LD ED V PDEK+I+TYV SFYH FS + RI
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
KVL E +++E YE+LA++LL WI RT+ + N+ N++ +QQ+L+ F Y L
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
KP K QEK LE+ ++Q+KLR NR F+P EG + DI+ AWG LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF-GYELPAVEAAMKKHEAIEAD 477
E+ R E+L+ LA++F K ++ E+W + + ++ Q ++ L ++A +KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537
+AA+++RV+ +A +AQ L YYD V A+ + QW L L RR LE+ L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 538 QKVFQEM 544
+ ++
Sbjct: 504 LETIDQL 510
Score = 64.3 bits (155), Expect = 1e-09
Identities = 96/486 (19%), Positives = 202/486 (41%), Gaps = 60/486 (12%)
Query: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
++ R+ ++L QE +L+ ++ ++A DL L W++ +P N +
Sbjct: 253 QKAETAANRICKVLAVNQENEQLM---EDYEKLASDL---LEWIRRTIPWLENRVPENTM 306
Query: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR--------RGLEQL 1599
A+QQ ++ + RR + P+++E + +L++ + R R + +
Sbjct: 307 HAMQQKLEDFRDYRRLHKP--PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDI 364
Query: 1600 QSAWAGLREAAE----------RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649
+AW L + + RR + LD E++ + EAW +E ++ +D
Sbjct: 365 NNAWGCLEQVEKGYEEWLLNEIRRLERLDHL--AEKFRQKASIHEAWTDGKEAMLRQKDY 422
Query: 1650 GKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
S ++ LLKKH E + +++ + Q++ + L E+ + DS ++ R ++
Sbjct: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQ 482
Query: 1709 YVALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760
+ L L ++RR ALE+ L + +++ + +W+ + E
Sbjct: 483 WDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIE 542
Query: 1761 HVSVLQEKFSEFASETGMAGRERLA--AVNQMVDELIECGHTAAATMAEW----KDGLNE 1814
+ L +F + A +ERLA ++ V ++++ H A + +N
Sbjct: 543 EIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
Query: 1815 AWAELLELMGTRAQLLAA--SRELH------KFFSDARELQGQIEEKRRRLPRLTTPPEP 1866
W + +L+ R Q L +R+ H +F + A + I+ K + R++ E
Sbjct: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EM 660
Query: 1867 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL---RTVYAGEHAEAIASREQEVLQG 1923
+ LR +E + ++ QL EG QL ++ +H + + G
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQLIQEALIFDNKHTNYTM---EHIRVG 716
Query: 1924 WKELLS 1929
W++LL+
Sbjct: 717 WEQLLT 722
Score = 43.5 bits (101), Expect = 0.003
Identities = 69/318 (21%), Positives = 135/318 (42%), Gaps = 32/318 (10%)
Query: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL- 1886
++LA ++E + D +L + E RR P + +MQ+ L F +L
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 1887 ---LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--------------QEVLQGWKELLS 1929
V + QL+ L+T + A E ++V +G++E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 1930 ACEDARLH-VSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSSVEVLMNYHQGL 1987
E RL + A+ R + + + +W DG + + D + +S ++ L+ H+
Sbjct: 384 N-EIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 1988 KTELEA---RVPELTT-CQELGRSLLLNK---SAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
+++L A RV ++ QEL + +A +I Q D LG ++ E +R
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 2041 WEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA- 2098
+ L+ + +++ ++A+ A + W+ LQ + +++E++ L HE F+
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
Query: 2099 AWEERFSSLRRLTTIEKI 2116
A +ER + L + KI
Sbjct: 561 ADKERLAILGIHNEVSKI 578
Score = 40.0 bits (92), Expect = 0.030
Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 530 RLEQNLALQKVFQEMVYMVD-WMEEMQAQLLSRECGQH-LVEADDLLQKHGLLEGDIAAQ 587
RLE+ L + F++ + + W + +A L ++ L E LL+KH E D+AA
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 588 SERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLW 647
+RVE + A A ++L Y C ++ L L + +RR LE + L
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ---KRREALERTEKLL 504
Query: 648 ALLQEL 653
+ +L
Sbjct: 505 ETIDQL 510
Score = 32.7 bits (73), Expect = 4.7
Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 1323 EKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR 1382
E ML +D ++ +H+AF ++LA +++ +E+I Q+L + + SV
Sbjct: 414 EAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN 473
Query: 1383 KKLGEIRQCWAELESTTQAKARQLFEASK----ADQLVQSFAE 1421
+ +I W L + TQ + L K DQL +A+
Sbjct: 474 ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Score = 32.0 bits (71), Expect = 8.1
Identities = 43/199 (21%), Positives = 77/199 (38%), Gaps = 18/199 (9%)
Query: 1065 ELGAEWGALASAAQACGE-AVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN--- 1120
++ WG L + E + RL+R H + F + G E L
Sbjct: 363 DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDY 422
Query: 1121 ---SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHL 1177
+L E ALL +H A + ++ ++ +I A ++ L D + +++ +
Sbjct: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD---SPSVNARCQKI 479
Query: 1178 ELGWHKLLGLWEARREALVQAH-----IYQLFLRDLRQALVVLRNQEMALSGAE---LPG 1229
W L L + RREAL + I QL+L ++A E A+ + +
Sbjct: 480 CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH 539
Query: 1230 TVESVEEALKQHRDFLTTM 1248
T+E ++ H F T+
Sbjct: 540 TIEEIQGLTTAHEQFKATL 558
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 405 bits (1042), Expect = e-112
Identities = 221/487 (45%), Positives = 310/487 (63%), Gaps = 8/487 (1%)
Query: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
E Q+KTFT W NSHL + G I ++ D RDG L LLEV+SGE+L +P RG+MR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE-----ET 144
Query: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
SAK+ LLLWCQ KTA Y VNIQNF SW+DGL F ALIHRHRP+L+D+ KL K +
Sbjct: 145 -SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
NL AF AE++L + ++LD ED V PDEK+I+TYV SFYH FS + RI
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
KVL E +++E YE+LA++LL WI RT+ + N+ N++ +QQ+L+ F Y L
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
KP K QEK LE+ ++Q+KLR NR F+P EG + DI+ AWG LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF-GYELPAVEAAMKKHEAIEAD 477
E+ R E+L+ LA++F K ++ E+W + + ++ Q ++ L ++A +KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537
+AA+++RV+ +A +AQ L YYD V A+ + QW L L RR LE+ L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 538 QKVFQEM 544
+ ++
Sbjct: 504 LETIDQL 510
Score = 64.3 bits (155), Expect = 1e-09
Identities = 96/486 (19%), Positives = 202/486 (41%), Gaps = 60/486 (12%)
Query: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
++ R+ ++L QE +L+ ++ ++A DL L W++ +P N +
Sbjct: 253 QKAETAANRICKVLAVNQENEQLM---EDYEKLASDL---LEWIRRTIPWLENRVPENTM 306
Query: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR--------RGLEQL 1599
A+QQ ++ + RR + P+++E + +L++ + R R + +
Sbjct: 307 HAMQQKLEDFRDYRRLHKP--PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDI 364
Query: 1600 QSAWAGLREAAE----------RRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDK 1649
+AW L + + RR + LD E++ + EAW +E ++ +D
Sbjct: 365 NNAWGCLEQVEKGYEEWLLNEIRRLERLDHL--AEKFRQKASIHEAWTDGKEAMLRQKDY 422
Query: 1650 GKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
S ++ LLKKH E + +++ + Q++ + L E+ + DS ++ R ++
Sbjct: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQ 482
Query: 1709 YVALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760
+ L L ++RR ALE+ L + +++ + +W+ + E
Sbjct: 483 WDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIE 542
Query: 1761 HVSVLQEKFSEFASETGMAGRERLA--AVNQMVDELIECGHTAAATMAEW----KDGLNE 1814
+ L +F + A +ERLA ++ V ++++ H A + +N
Sbjct: 543 EIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEING 602
Query: 1815 AWAELLELMGTRAQLLAA--SRELH------KFFSDARELQGQIEEKRRRLPRLTTPPEP 1866
W + +L+ R Q L +R+ H +F + A + I+ K + R++ E
Sbjct: 603 KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EM 660
Query: 1867 RPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL---RTVYAGEHAEAIASREQEVLQG 1923
+ LR +E + ++ QL EG QL ++ +H + + G
Sbjct: 661 HGTLEDQLSHLRQYEKSIVNYKPKIDQL-EGDHQLIQEALIFDNKHTNYTM---EHIRVG 716
Query: 1924 WKELLS 1929
W++LL+
Sbjct: 717 WEQLLT 722
Score = 43.5 bits (101), Expect = 0.003
Identities = 69/318 (21%), Positives = 135/318 (42%), Gaps = 32/318 (10%)
Query: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL- 1886
++LA ++E + D +L + E RR P + +MQ+ L F +L
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 1887 ---LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--------------QEVLQGWKELLS 1929
V + QL+ L+T + A E ++V +G++E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 1930 ACEDARLH-VSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSSVEVLMNYHQGL 1987
E RL + A+ R + + + +W DG + + D + +S ++ L+ H+
Sbjct: 384 N-EIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETATLSEIKALLKKHEAF 440
Query: 1988 KTELEA---RVPELTT-CQELGRSLLLNK---SAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
+++L A RV ++ QEL + +A +I Q D LG ++ E +R
Sbjct: 441 ESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERT 500
Query: 2041 WEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA- 2098
+ L+ + +++ ++A+ A + W+ LQ + +++E++ L HE F+
Sbjct: 501 EKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD 560
Query: 2099 AWEERFSSLRRLTTIEKI 2116
A +ER + L + KI
Sbjct: 561 ADKERLAILGIHNEVSKI 578
Score = 40.0 bits (92), Expect = 0.030
Identities = 34/126 (26%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 530 RLEQNLALQKVFQEMVYMVD-WMEEMQAQLLSRECGQH-LVEADDLLQKHGLLEGDIAAQ 587
RLE+ L + F++ + + W + +A L ++ L E LL+KH E D+AA
Sbjct: 388 RLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAH 447
Query: 588 SERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLW 647
+RVE + A A ++L Y C ++ L L + +RR LE + L
Sbjct: 448 QDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQ---KRREALERTEKLL 504
Query: 648 ALLQEL 653
+ +L
Sbjct: 505 ETIDQL 510
Score = 32.7 bits (73), Expect = 4.7
Identities = 26/103 (25%), Positives = 47/103 (45%), Gaps = 4/103 (3%)
Query: 1323 EKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVR 1382
E ML +D ++ +H+AF ++LA +++ +E+I Q+L + + SV
Sbjct: 414 EAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVN 473
Query: 1383 KKLGEIRQCWAELESTTQAKARQLFEASK----ADQLVQSFAE 1421
+ +I W L + TQ + L K DQL +A+
Sbjct: 474 ARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Score = 32.0 bits (71), Expect = 8.1
Identities = 43/199 (21%), Positives = 77/199 (38%), Gaps = 18/199 (9%)
Query: 1065 ELGAEWGALASAAQACGE-AVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN--- 1120
++ WG L + E + RL+R H + F + G E L
Sbjct: 363 DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDY 422
Query: 1121 ---SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHL 1177
+L E ALL +H A + ++ ++ +I A ++ L D + +++ +
Sbjct: 423 ETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD---SPSVNARCQKI 479
Query: 1178 ELGWHKLLGLWEARREALVQAH-----IYQLFLRDLRQALVVLRNQEMALSGAE---LPG 1229
W L L + RREAL + I QL+L ++A E A+ + +
Sbjct: 480 CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH 539
Query: 1230 TVESVEEALKQHRDFLTTM 1248
T+E ++ H F T+
Sbjct: 540 TIEEIQGLTTAHEQFKATL 558
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 403 bits (1036), Expect = e-111
Identities = 258/685 (37%), Positives = 376/685 (54%), Gaps = 40/685 (5%)
Query: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
E Q+KTFT W NSHL + G I ++ D R+G L LLEV+SGE+LPRP +G+MR H
Sbjct: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
Query: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVE-----ET 158
Query: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
SAK+ LLLWCQ KTA Y VN+QNF TSW+DGLA ALIHRHRPDL+D++KL K +
Sbjct: 159 -SAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
Query: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
NL AF AE++L + ++LD ED VN PDEK+I+TYV FYH F+ + RI
Sbjct: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
Query: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
KVL E K++E YE+LA+ELL WI RTV + N+ S+S +Q++L+ F Y L
Sbjct: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
Query: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
KP + QEK LE+ ++Q+KLR +R F+P EG + DI AW LE+ E E L
Sbjct: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
Query: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYE-LPAVEAAMKKHEAIEAD 477
+E+ R ++L+ LA++F K ++ E+W + ++SQ ++ L V A +++HEA E+D
Sbjct: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESD 457
Query: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537
+AA+++RV+ +A LAQ L Y++ V ++ ++ QW L L RR LE+ L
Sbjct: 458 LAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKL 517
Query: 538 QKVFQEM--------VYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDI-AAQS 588
+ ++ +W++ L + E LL H + + A
Sbjct: 518 LETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADR 577
Query: 589 ER--VEALNAAALRFSQLQGYQPC--------DPQVICNRVNHVHGCLAE----LQEQAA 634
ER + + + Q G +PC PQ I + + V + LQE+ A
Sbjct: 578 ERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
Query: 635 RRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
R++ R A + W + K + G AAG AG+ L
Sbjct: 638 RQQVNERLRRQFAA---QANAIGPWIQAKVEEV----GRLAAGLAGSLEEQMAG--LRQQ 688
Query: 695 ARLLAQHKILQGELGGRRALLQQAL 719
+ + +K L G LLQ++L
Sbjct: 689 EQNIINYKTNIDRLEGDHQLLQESL 713
Score = 52.0 bits (123), Expect = 8e-06
Identities = 93/493 (18%), Positives = 191/493 (38%), Gaps = 72/493 (14%)
Query: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
E+ R+ ++L QE +L+ +E ++A +L L W++ +P +
Sbjct: 267 EQAETAANRICKVLAVNQENEKLM---EEYEKLASEL---LEWIRRTVPWLENRVGEPSM 320
Query: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLE------------RAGALASLRSPEAEAVR-- 1593
A+Q+ ++ + RR + PR++E + R + E + V
Sbjct: 321 SAMQRKLEDFRDYRRLHKP--PRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDI 378
Query: 1594 ----RGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWL-GEQELLMMSED 1648
RGLEQ++ + + RR Q L E++ + EAW G++E+L +
Sbjct: 379 ANAWRGLEQVEKGYEDWLLSEIRRLQRLQHL--AEKFRQKASLHEAWTRGKEEMLSQRDY 436
Query: 1649 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
Q LL++H E + +++ + ++ + L E+ + ++ ++ R +
Sbjct: 437 DSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQ 496
Query: 1709 YVALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760
+ L L ++RR ALE+ L + +R+ + +W+ L E
Sbjct: 497 WDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVE 556
Query: 1761 HVSVLQEKFSEFASETGMAGRER--LAAVNQMVDELIE------CGHTAAATMAEWKDGL 1812
L +F + A RER + + + ++ + C T++ +
Sbjct: 557 ETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLS--PQDI 614
Query: 1813 NEAWAELLELMGTRAQLL--------AASRELHKFFSDARELQGQIEEKRRRLPRLT--- 1861
N W + +L+ +R Q L R +F + A + I+ K + RL
Sbjct: 615 NTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGL 674
Query: 1862 --TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA--QLRTVYAGEHAEAIASRE 1917
+ E ++ + ++ ++ L + LQE TVY+ EH
Sbjct: 675 AGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEH-------- 726
Query: 1918 QEVLQGWKELLSA 1930
+ GW++LL++
Sbjct: 727 --IRVGWEQLLTS 737
Score = 48.5 bits (114), Expect = 8e-05
Identities = 71/308 (23%), Positives = 126/308 (40%), Gaps = 30/308 (9%)
Query: 1815 AWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873
A AE E R ++LA ++E K + +L ++ E RR PS S+M
Sbjct: 264 AGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAM 323
Query: 1874 QRTLRAFEHDLQL----LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL-------Q 1922
QR L F +L + + QL+ L+T H A E +++ +
Sbjct: 324 QRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWR 383
Query: 1923 GWKELLSACEDARL-------HVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDV- 1974
G +++ ED L + A+ R + + + +W G + D +
Sbjct: 384 GLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHE--AWTRGKEEMLSQRDYDSALL 441
Query: 1975 SSVEVLMNYHQGLKTELEA---RVPELTT-CQELGRSLLLNKSAMADEIQA---QLDKLG 2027
V L+ H+ +++L A RV + QEL +++ QA Q D LG
Sbjct: 442 QEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLG 501
Query: 2028 TRKEEVSEKWDRHWEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQL 2086
T ++ + +R + L+ + ++ +FA+ A + WL LQ L SV+E + L
Sbjct: 502 TLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSL 561
Query: 2087 IRRHEAFR 2094
+ H+ F+
Sbjct: 562 LTAHDQFK 569
Score = 44.3 bits (103), Expect = 0.002
Identities = 100/469 (21%), Positives = 187/469 (39%), Gaps = 42/469 (8%)
Query: 1234 VEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLR 1293
++E + +F T + + A +EG L + E V + E +++R
Sbjct: 342 IQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIR 401
Query: 1294 AQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAEL 1353
Q +Q L ++ + L HE E+ML RD ++ RH+AF ++L
Sbjct: 402 RLQRLQHLAEKFRQKASL---HEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458
Query: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK-- 1411
A +++ +E I Q+L + AASV + I W L + TQ + L K
Sbjct: 459 AAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLL 518
Query: 1412 --ADQLVQSFAELDKKLLH-MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGE 1468
DQL FA + ++ ++D+ D+ V+S +++ QS+ + +++ + E
Sbjct: 519 ETIDQLQLEFARRAAPFNNWLDGAVEDLQ---DVWLVHS-VEETQSLLTAHDQFKATLPE 574
Query: 1469 LQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDEL 1528
+ A+ + GE Q +R P + L+ + D++ +
Sbjct: 575 ADRERGAI------MGIQGEIQKICQTYGLR---PCSTNPYITLSPQ-------DINTKW 618
Query: 1529 AWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH----GPRLEEVLERAGALASL 1584
V++ +P QT LQ + N+ LRR+ A GP ++ +E G LA+
Sbjct: 619 DMVRKLVPSRDQT-----LQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAG 673
Query: 1585 RSPEAEAVRRGLEQLQSAWAGLREAAERRQ---QVLDAAFQVEQYYFDVAEVEAWLG-EQ 1640
+ E GL Q + + +R + Q+L + + + + +G EQ
Sbjct: 674 LAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQ 733
Query: 1641 ELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 1689
L ++ + E L K L EQ + + S R+ ++E
Sbjct: 734 LLTSIARTINEVENQVLTRDAKGLSQEQ-LNEFRASFNHFDRKRNGMME 781
Score = 44.3 bits (103), Expect = 0.002
Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 3/73 (4%)
Query: 2039 RHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSV-DEVEQLIRRHEAFRKAA 2097
R + LQ + E +F Q+A + +AW +E +L R+ S++ EV L+RRHEAF
Sbjct: 401 RRLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458
Query: 2098 AAWEERFSSLRRL 2110
AA ++R + L
Sbjct: 459 AAHQDRVEHIAAL 471
Score = 36.6 bits (83), Expect = 0.33
Identities = 78/352 (22%), Positives = 139/352 (39%), Gaps = 57/352 (16%)
Query: 873 RRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDS--LDDVEVVQHRFESLDQEM 930
R Q L+ +R +H E W KE+ +LS R DS L +V + R E+ + ++
Sbjct: 402 RLQRLQHLAEKFRQKASLH--EAWTRGKEE-MLSQRDYDSALLQEVRALLRRHEAFESDL 458
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
+ RV + QEL E + + V S + +W+ + L ++R++ + +
Sbjct: 459 AAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERM---- 514
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQ-----WRLSGLE---AALQALEPRQAAL- 1041
+LE + + Q+ RRA GA++ W + +E + L A + +A L
Sbjct: 515 EKLLETID-QLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP 573
Query: 1042 ---LEEAALLAERFPAQAARLHQG-------------AEELGAEWG----ALASAAQACG 1081
E A++ + Q G +++ +W + S Q
Sbjct: 574 EADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQ 633
Query: 1082 EAVA---AAGRLQR-FLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAA--- 1134
E +A RL+R F +A W+ E G L SLEE A L +
Sbjct: 634 EELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNII 693
Query: 1135 -LKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLL 1185
K +D+ E D+ + E+L+ + + + H+ +GW +LL
Sbjct: 694 NYKTNIDRLEGDHQLL---QESLVFDNKHTVYS-------MEHIRVGWEQLL 735
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 398 bits (1022), Expect = e-110
Identities = 241/614 (39%), Positives = 341/614 (55%), Gaps = 31/614 (5%)
Query: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
E Q+KTFT W NSHL + G I ++ D R+G L LLEV+SGE+LP+P RG+MR H
Sbjct: 37 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHK 96
Query: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
+ NV+KAL ++ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 97 IANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVE-----ET 151
Query: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
SAK+ LLLWCQ KTA Y VNIQNF TSW+DGL ALIHRHRPDL+D+SKL K +
Sbjct: 152 -SAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIG 210
Query: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
N+ A AE+HL + ++LD ED VN PDE++I+TYV FYH F+ + RI
Sbjct: 211 NINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRIC 270
Query: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
KVL E +++E YE LA+ELL WI RT+ + N+ ++ +Q++L+ F Y
Sbjct: 271 KVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKH 330
Query: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
KP K QEK LE+ ++Q+KLR NR F+P EG + DI AW LE+AE E L
Sbjct: 331 KPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLL 390
Query: 419 AELIRQEKLELLAQRFDHKVAMRESW-LNENQRLVSQDNFGYELPAVEAAMKKHEAIEAD 477
E+ R E+LE LA++F K + E+W + Q L+ +D L V A ++KHEA E+D
Sbjct: 391 NEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD 450
Query: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537
+AA+++RV+ +A +AQ L Y+D V + + QW L L RR LE+ L
Sbjct: 451 LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKL 510
Query: 538 QKVFQEM--------VYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH-----------G 578
+ ++ +WME L + E L+ H G
Sbjct: 511 LETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADG 570
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCL----AELQEQAA 634
+ +A Q+E + + + +R S Y + + + V + LQE+ A
Sbjct: 571 ERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELA 630
Query: 635 RRRAELEASRSLWA 648
R+ A R A
Sbjct: 631 RQHANERLRRQFAA 644
Score = 58.9 bits (141), Expect = 6e-08
Identities = 88/484 (18%), Positives = 200/484 (41%), Gaps = 56/484 (11%)
Query: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
E+ R+ ++L QE RL+ +E ++A +L L W++ +P +
Sbjct: 260 EQAETAANRICKVLAVNQENERLM---EEYERLASEL---LEWIRRTIPWLENRTPEKTM 313
Query: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVR--------RGLEQL 1599
QA+Q+ ++ + RR+ + P+++E + +L++ + R + + +
Sbjct: 314 QAMQKKLEDFRDYRRKHKP--PKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDI 371
Query: 1600 QSAWAGLREAAERRQQVLDAAFQ--------VEQYYFDVAEVEAWL-GEQELLMMSEDKG 1650
AW L +A + ++ L + E++ + E W G++++L+ + +
Sbjct: 372 AGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYES 431
Query: 1651 KDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYV 1710
LL+KH E + +++ + Q++ + L E+ + D+ ++ R ++ +
Sbjct: 432 ASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWD 491
Query: 1711 ALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 1762
L L ++RR ALE+ L + +++ + +W+ + E +
Sbjct: 492 RLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEI 551
Query: 1763 SVLQEKFSEFASETGMAGRER--LAAVNQMVDELIECGHTAAATMAEWK----DGLNEAW 1816
L +F + A ER + A+ V+++I+ + ++ + D L W
Sbjct: 552 QSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKW 611
Query: 1817 AELLELMGTRAQLL--------AASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
++ +L+ R Q L A R +F + A + I+ K + R + +
Sbjct: 612 DKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSI--QITG 669
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL---RTVYAGEHAEAIASREQEVLQGWK 1925
+ L+ +EH++ + + +L EG QL V+ +H + + GW+
Sbjct: 670 ALEDQMNQLKQYEHNIINYKNNIDKL-EGDHQLIQEALVFDNKHTNYTM---EHIRVGWE 725
Query: 1926 ELLS 1929
LL+
Sbjct: 726 LLLT 729
Score = 48.5 bits (114), Expect = 8e-05
Identities = 73/329 (22%), Positives = 134/329 (40%), Gaps = 27/329 (8%)
Query: 1815 AWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873
A AE E R ++LA ++E + + L ++ E RR P + +M
Sbjct: 257 AGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAM 316
Query: 1874 QRTLRAFEHDLQL----LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE----QEVLQGWK 1925
Q+ L F + V + QL+ L+T + A E ++ W+
Sbjct: 317 QKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQ 376
Query: 1926 ELLSA---CEDARLHVSSTADAL-----RFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
L A E+ L+ + L +F + +W G + D + ++
Sbjct: 377 RLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTE 436
Query: 1977 VEVLMNYHQGLKTELEA---RVPELTTC----QELGRSLLLNKSAMADEIQAQLDKLGTR 2029
V L+ H+ +++L A RV ++ EL +N + +I Q D+LGT
Sbjct: 437 VRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTL 496
Query: 2030 KEEVSEKWDRHWEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIR 2088
++ E +R + L+ + ++H +FA+ A + W+ LQ + S++E++ LI
Sbjct: 497 TQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLIT 556
Query: 2089 RHEAFRKA-AAAWEERFSSLRRLTTIEKI 2116
HE F+ A ER S + +EK+
Sbjct: 557 AHEQFKATLPEADGERQSIMAIQNEVEKV 585
Score = 42.7 bits (99), Expect = 0.005
Identities = 74/354 (20%), Positives = 149/354 (42%), Gaps = 41/354 (11%)
Query: 1234 VEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLR 1293
V+E + +F T + + A +EG + Q E + E+ N++R
Sbjct: 335 VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIR 394
Query: 1294 AQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAEL 1353
+ ++ L ++ + HE + E++L+ +D ++ +H+AF ++L
Sbjct: 395 RLERLEHLAEKFRQK---ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDL 451
Query: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK-- 1411
A +++ +E+I Q+L + A +V + +I W L + TQ + L K
Sbjct: 452 AAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLL 511
Query: 1412 --ADQLVQSFAELDKKLLH-MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGE 1468
DQL FA+ + ME ++D+ D+ V+S ++++QS+ + E++
Sbjct: 512 ETIDQLHLEFAKRAAPFNNWMEGAMEDLQ---DMFIVHS-IEEIQSLITAHEQF------ 561
Query: 1469 LQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDEL 1528
A LP E GERQ+ + + +E + + + ++S + +
Sbjct: 562 ----KATLP------EADGERQSIMA--IQNEVEKVIQSYNIRISSSNPYSTVTMDELRT 609
Query: 1529 AW--VQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH----GPRLEEVLE 1576
W V++ +P+ R LQ N+ LRR+ A GP ++ +E
Sbjct: 610 KWDKVKQLVPI-----RDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKME 658
Score = 40.4 bits (93), Expect = 0.023
Identities = 68/339 (20%), Positives = 134/339 (39%), Gaps = 34/339 (10%)
Query: 1065 ELGAEWGALASAAQACGE-AVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPN--- 1120
++ W L A + E + RL+R H + F + A G E L
Sbjct: 370 DIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDY 429
Query: 1121 ---SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHL 1177
SL E ALL +H A + ++ ++ +I A ++ L D + + +++ +
Sbjct: 430 ESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD---AVNVNDRCQKI 486
Query: 1178 ELGWHKLLGLWEARREALVQAH-----IYQLFLRDLRQALVVLRNQEMALSGAE---LPG 1229
W +L L + RREAL + I QL L ++A E A+ + +
Sbjct: 487 CDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVH 546
Query: 1230 TVESVEEALKQHRDFLTTM---ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEK 1286
++E ++ + H F T+ + +Q + E +++ NI + T +++
Sbjct: 547 SIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDE 606
Query: 1287 NQENQLRAQQWM----QKLHDQLELQH--------FLRDCHELDGWIHEKMLMARDGTRE 1334
+ + +Q + Q L ++L QH F + + WI KM + +
Sbjct: 607 LRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQ 666
Query: 1335 DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQE 1373
L + + + + + K ++K+E + QL+QE
Sbjct: 667 ITGALEDQMNQLKQYEHNIINYKNNIDKLEGD-HQLIQE 704
Score = 37.0 bits (84), Expect = 0.25
Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 7/132 (5%)
Query: 855 RVVEAEQLFAE--VTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPD- 911
R+ +AE+ + E + E+ L R L +R H E W KEQ LL
Sbjct: 377 RLEQAEKGYEEWLLNEIRRLER--LEHLAEKFRQKASTH--ETWAYGKEQILLQKDYESA 432
Query: 912 SLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNR 971
SL +V + + E+ + ++ + RV + QEL E + + V + +W+R
Sbjct: 433 SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDR 492
Query: 972 IVELVEQRKEEM 983
+ L ++R+E +
Sbjct: 493 LGTLTQKRREAL 504
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 361 bits (927), Expect = 4e-99
Identities = 332/1377 (24%), Positives = 578/1377 (41%), Gaps = 65/1377 (4%)
Query: 744 LAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGH 803
+ ER R+Q +E A R ++L+++ L F D D L W+ + + +
Sbjct: 24 IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY-E 82
Query: 804 DEASSRRLARQHRALTGEVEAHRGPVSGL---RRQLATLGGASGAGPLVVALQVRVVEAE 860
D + + ++H++L EV+ +S L R + T+G ++ + + E
Sbjct: 83 DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHE-----ETKAHIEELR 137
Query: 861 QLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQ 920
L+ + E+ + L AL + E WIG+KE S+ + + + EV+
Sbjct: 138 HLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLH 197
Query: 921 HRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRK 980
+FE E+ + GRV++VN E E HP ++S Q+ +N+ W R+ L QR+
Sbjct: 198 KKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
Query: 981 EEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPR-----AGGALQWRLSGLEAALQALE 1035
+ +S ++ +V E ++EK + S A L GLE L +
Sbjct: 258 KALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMS 317
Query: 1036 PRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLH 1095
+ L +A L P+ A ++ + E+L + W + + A + E + A RF
Sbjct: 318 DKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSS 377
Query: 1096 DLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEA 1155
D D W+ A E LP + + LL RH K E+D ++ + +
Sbjct: 378 DFDELSGWMNEKTAAINADE--LPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
Query: 1156 LLAADGAELGPGLALDEWLPHLEL---GWHKLLGLWEARREALVQAHIYQLFLRDLRQAL 1212
L+ A+ A DE +E+ W LL LW+ R Q + LF RD Q
Sbjct: 436 LVNANHE------ASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVD 489
Query: 1213 VVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIY 1272
+ QE L +L ++ S E L++H DF ++K+ + A L+ +
Sbjct: 490 SWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYD 549
Query: 1273 GEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGT 1332
E + LL + + +A + L + L LQ D +L WI++K +A D
Sbjct: 550 SENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDED 609
Query: 1333 REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCW 1392
+D L R + Q F ELA NK LE I++ GQ++++ + +V +L E+ W
Sbjct: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
Query: 1393 AELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKL 1452
EL T+ K QL EA++ Q + +L + L +E Q+ D G LA V ++L+K
Sbjct: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
Query: 1453 QSMESQVEEWYREVGELQAQTAALPL--EPASKELVGERQNAVGERLVRLLEPLQERRRL 1510
+ES V +V L A P SK+ + RQ ++ R L EPL R++
Sbjct: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKD-IRARQESLVCRFEALKEPLATRKKK 788
Query: 1511 LLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPR 1570
LL L + D +DE AW+QE P A T G L A ++ + +++ + I +H PR
Sbjct: 789 LLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPR 848
Query: 1571 LEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDV 1630
++E+ ER + AE V ++ L LR A RRQ L+A Q +QY D+
Sbjct: 849 IQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADL 908
Query: 1631 AEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEM 1690
E E W+ E+E ++ + + G DE++ LLKKH + ++ +S+ L Q A +
Sbjct: 909 HEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQ 968
Query: 1691 GHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVA 1750
E ++ GE+R +A LY + S E + + +V+
Sbjct: 969 QAAPVEGVA----------------GEQRVMA------LYDFQAR-SPREVTMKKGDVLT 1005
Query: 1751 GSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD 1810
+ +D+ V + A + + Q E + + ++
Sbjct: 1006 LLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRRE-------EPGNITQRQE 1058
Query: 1811 GLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 1870
+ + LL+ R + L +A ++ I+EK+ T E
Sbjct: 1059 QIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE----NTGVE-LDDV 1113
Query: 1871 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 1930
+Q+ F+ DL ++R + + A L ++ G A QE+ W L
Sbjct: 1114 WELQKKFDEFQKDLNTNEPRLRDINKVADDL--LFEGLLTPEGAQIRQELNSRWGSLQRL 1171
Query: 1931 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTE 1990
++ R + S FH + D ++ + AAD D+ SV+ L H+G + +
Sbjct: 1172 ADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERD 1231
Query: 1991 LEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
L ++T E L + +++Q Q +L E++ + E L + +
Sbjct: 1232 LVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKF 1291
Query: 2051 HQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
+ F +A W+++ ++ S+EL + +E L+ RH+ R A F +L
Sbjct: 1292 YLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQAL 1348
Score = 332 bits (852), Expect = 2e-90
Identities = 387/1741 (22%), Positives = 721/1741 (41%), Gaps = 151/1741 (8%)
Query: 398 DIDKAWGELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNF 457
++ W EL +A ++ L ++L+ F++ + WL + + V+ +++
Sbjct: 664 EVASLWEELLEATKQKGTQLHEA---NQQLQ-----FENNAEDLQRWLEDVEWQVTSEDY 715
Query: 458 GYELPAVEAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQW 517
G L V+ ++KH +E+ +AA +++V + +LA G+ D + + A+++S++ ++
Sbjct: 716 GKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRF 775
Query: 518 ALLTGLVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH 577
L + R+ +L L LQ + ++ W++E + S G+ L+ + LL +H
Sbjct: 776 EALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRH 835
Query: 578 GLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRR 637
++ +IA+ R++ + + + + D + +RV ++ + L+ +AARR+
Sbjct: 836 RVILENIASHEPRIQEITERGNKMVEEGHFAAED---VASRVKSLNQNMESLRARAARRQ 892
Query: 638 AELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARL 697
+LEA+ L +L EAE+W R+KE +++ G AAGA L
Sbjct: 893 NDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGA---------------L 937
Query: 698 LAQHKILQGELGG----RRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARR 753
L +H+ +L +AL QA C ++ A V + +
Sbjct: 938 LKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGV-----------------AGEQ 980
Query: 754 RWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASS-RRLA 812
R L + AR R + + G L L +D +++ AA G A RRLA
Sbjct: 981 RVMALYDFQARSPREVTMKK-----GDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
Query: 813 RQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAAL 872
+ + P + +RQ + E + + + A
Sbjct: 1036 HDEFPMLPQ-RRREEPGNITQRQ---------------------EQIENQYRSLLDRAEE 1073
Query: 873 RRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNS 932
RR+ L + + E WI EK+ + LDDV +Q +F+ +++N+
Sbjct: 1074 RRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNT 1129
Query: 933 LMGRVLDVNHTVQELVEGG--HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
R+ D+N +L+ G P ++R LNSRW + L +++++ + + VE
Sbjct: 1130 NEPRLRDINKVADDLLFEGLLTPEGAQIRQ---ELNSRWGSLQRLADEQRQLLGSAHAVE 1186
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGG-----ALQWRLSGLEAALQALEPRQAALLEEA 1045
E + + Q+ +K +A+ +A ALQ R G E L L + L E A
Sbjct: 1187 VFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETA 1246
Query: 1046 ALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLV 1105
L+E P L + EL W L + E++ A + FL +W+
Sbjct: 1247 ERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWI- 1305
Query: 1106 RAQEAAGG--SEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAE 1163
+ GG S L L + LL RH + +++ + + S L+ + G
Sbjct: 1306 ---SSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDS-GHH 1361
Query: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALS 1223
P +++ L ++L L WE R++ L Q Q+F + Q + +E +L
Sbjct: 1362 ASP--EIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLR 1419
Query: 1224 GAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283
+ +++S+E +K+ D + + K+ AE L+ + E+ + R+
Sbjct: 1420 SDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIATRLQRV 1478
Query: 1284 LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
L++ + + + KL D L+ F RD EL+ WI E + A D + +D + +++
Sbjct: 1479 LDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKY 1538
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKP--ELAASVRKKLGEIRQCWAELESTTQA 1401
L+HQ F E+ E + + G L++ +++++L ++++ W L T
Sbjct: 1539 LKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTND 1598
Query: 1402 KARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQV-- 1459
K ++L EAS+ + S + + L E+ L D DLA+ + LKK Q +E ++
Sbjct: 1599 KGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1658
Query: 1460 -EEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELH 1518
E+ +++ L L + + + ++++ V +R + + E L + L
Sbjct: 1659 REDALKDLNTLAEDL--LSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALF 1716
Query: 1519 QVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERA 1578
Q DLDDE +W++E+L + G LQ VQ +KK++ L E+ AH P ++ VL+ A
Sbjct: 1717 QFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMA 1776
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLG 1638
L + E ++ L Q W L+E A+ R L+ + + Q+ + E EAW+
Sbjct: 1777 EKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWIN 1836
Query: 1639 EQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQI 1698
E+ L + D G +T LL KH LE +E + + Q +L + Q
Sbjct: 1837 EKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQN 1896
Query: 1699 SRRQSQVDRLYVALKELGE---ERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPEL 1755
S+++ L L + ++ LE Y + + + +E WIA+KE +
Sbjct: 1897 KEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGN 1956
Query: 1756 GQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEA 1815
G D L K + +ERL + + D+LI H + + E L +
Sbjct: 1957 GADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKR 2016
Query: 1816 WAELLELMGT-RAQLLAASRELHK-------FFSDARELQGQIEEKRRRLPRLTTPPEPR 1867
W +LLE R +LL L K F A L E+ L EP
Sbjct: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENL------SEPV 2070
Query: 1868 PSAS-----SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ 1922
S +Q+ F L + + L E Q++ + G + EVL+
Sbjct: 2071 HCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKAL--GVPSSPYTWLTVEVLE 2128
Query: 1923 -GWKELLSACEDAR--------LHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
WK L E+ V + F L W+ + ++
Sbjct: 2129 RTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGSLLKE 2188
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
++E + ++ + E++A +LT +LG +L + A+ +I + +G +
Sbjct: 2189 TGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL---EDALILDI--KYSTIG-----L 2238
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+++WD+ ++ +M H Q+ D ++E L + + DE H+ F
Sbjct: 2239 AQQWDQLYQLGLRM--QHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEF 2296
Query: 2094 R 2094
R
Sbjct: 2297 R 2297
Score = 278 bits (711), Expect = 5e-74
Identities = 380/1809 (21%), Positives = 699/1809 (38%), Gaps = 172/1809 (9%)
Query: 423 RQEKLELLA--QRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAA 480
R EKL+ RF W+NE ++ D ++ E + +H+ + +I +
Sbjct: 362 RYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDS 421
Query: 481 YEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKV 540
Y++R Q E Q L + V + + + W L L R + EQ L
Sbjct: 422 YDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
Query: 541 FQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALR 600
+++ + WM +A L + + G L A+ LLQKH E AQ E++ ++ A +
Sbjct: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
Query: 601 FSQLQGYQPCDPQVICNRVNHVHGCLAE---LQEQAARRRAELEASRSLWALLQELEEAE 657
Y + + I + G LA L+E+AA RR L+ S L L ++ ++ +
Sbjct: 542 LIGDDHYDSENIKAIRD------GLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLK 595
Query: 658 SWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQ 717
+W K++L + D+ + + + ++ + EL + L+
Sbjct: 596 NWINKKKKLADDED----------------YKDIQNLKSRVQKQQVFEKELAVNKTQLEN 639
Query: 718 ALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQ 777
+ G+E++ G T R + W+ L EA ++ +L EA Q
Sbjct: 640 IQKTGQEMIEGGHYASDNVTT--------RLSEVASLWEELLEATKQKGTQLHEANQQLQ 691
Query: 778 FGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLA 837
F + + L WL D + D+G A + R+H L V A + V L LA
Sbjct: 692 FENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILT-DLA 750
Query: 838 TLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWI 897
G P ++ R F + E A R++ L D L + + + E WI
Sbjct: 751 AYFEEIGH-PDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWI 809
Query: 898 GEKEQWLLSM---------------------------------------RVPDSLDDVEV 918
E E S V + E
Sbjct: 810 QETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAED 869
Query: 919 VQHRFESLDQEMNSLMGRV------LDVNHTVQELVEGGHPSSDEVRSCQDHL-NSRWNR 971
V R +SL+Q M SL R L+ N Q+ + H + +R + + N+ +
Sbjct: 870 VASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGA 929
Query: 972 IVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAAL 1031
E ++ A LL N + + + ++AP G A + R+ L
Sbjct: 930 DEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYD-F 988
Query: 1032 QALEPRQAALL-------------------------------------EEAALLAERFPA 1054
QA PR+ + +E +L +R
Sbjct: 989 QARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRRE 1048
Query: 1055 QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA--FLDWLVRAQEAAG 1112
+ + Q E++ ++ +L A+ + R FL +A L+W+ +
Sbjct: 1049 EPGNITQRQEQIENQYRSLLDRAEERRRRLLQ--RYNEFLLAYEAGDMLEWIQEKKAENT 1106
Query: 1113 GSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAAS-----EALLAADGAELGPG 1167
G E L++ L + +++++ E I + E LL +GA++
Sbjct: 1107 GVE------LDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQ- 1159
Query: 1168 LALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAEL 1227
L W L L + +R+ L AH ++F R+ + + ALS A+
Sbjct: 1160 --------ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADP 1211
Query: 1228 PGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKN 1287
+ SV+ ++H F + K+ + + AE L E Q L E
Sbjct: 1212 GSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAW 1271
Query: 1288 QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHE-KMLMARDGTREDNHKLHKRWLRH 1346
++ Q R + + L++ + FL +L WI +++ ED + RH
Sbjct: 1272 EDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERH 1331
Query: 1347 QAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQL 1406
Q A++ + +E +L+ + + KKL ++ +LE + + + L
Sbjct: 1332 QEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKIL 1391
Query: 1407 FEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV 1466
+ + + +++ ++ E+ L+ D L ++ + +KK ++ + ++
Sbjct: 1392 DQCLELQMFQGNCDQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEGKI 1450
Query: 1467 GELQAQTAALPL-EPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLD 1525
+L+ +L E +KE + R V +R L L + R L L Q DL+
Sbjct: 1451 TDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLE 1510
Query: 1526 DELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLR 1585
+ W+ E LP A E +Q+ K+Q E+ ++ V+ +L
Sbjct: 1511 ELEEWISEMLPTACD-ESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECS 1569
Query: 1586 SPEA--EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELL 1643
+ + EA++ LEQL+ W L E + + L+ A + +++ + + E WL E E L
Sbjct: 1570 ACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETL 1629
Query: 1644 MMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQS 1703
+ +D+ +D S LLKKH LE+ + E+++ L+ LL G + +QI +++
Sbjct: 1630 LAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKD 1689
Query: 1704 QVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 1763
V++ ++ ++EL L++ Y L+Q + + + E WI EK + S + G+D + V
Sbjct: 1690 NVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQ 1749
Query: 1764 VLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELM 1823
L +K E +A + V M ++L + + E W +L EL
Sbjct: 1750 NLLKKHKRLEGEL-VAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELA 1808
Query: 1824 GTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHD 1883
R L S E +F +A E + I EK R + + S+ A E+D
Sbjct: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCG-DTLAATQSLLMKHEALEND 1867
Query: 1884 LQLLVSQVRQL-QEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSACEDARLHVSST 1941
+ ++V+ + +G L V E + I+S+ + + + L A +L +
Sbjct: 1868 FAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDD 1927
Query: 1942 ADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEA----RVPE 1997
F+ + + +W+ + + D+ L+ L L++ R+PE
Sbjct: 1928 YAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPE 1987
Query: 1998 LTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWE-WLQQMLEVH----- 2051
+T ++ S N+S +E A L K R E++ E H + L++ L +
Sbjct: 1988 ITDLKDKLISAQHNQSKAIEERYAALLK---RWEQLLEASAVHRQKLLEKQLPLQKAEDL 2044
Query: 2052 --QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRR 2109
+FA +A + W E L S++E+ QL + HE F + A + F L
Sbjct: 2045 FVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLE 2104
Query: 2110 LTTIEKIKA 2118
L ++IKA
Sbjct: 2105 LD--QQIKA 2111
Score = 267 bits (682), Expect = 1e-70
Identities = 373/1843 (20%), Positives = 728/1843 (39%), Gaps = 137/1843 (7%)
Query: 303 QVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFAN--SLSGVQQQLQAFTAYCTLEKP 360
Q LE ++ ++ A +L WI V +++++ + + ++ G Q+ Q+ A
Sbjct: 47 QKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSYEDPTNIQGKYQKHQSLEA------- 99
Query: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
+ Q K L S+L F ++ +E+ H + L
Sbjct: 100 -EVQTKSRL-------MSELEKTREERFTMGHSAH----EETKAHIEELRHLWDLLLELT 147
Query: 421 LIRQEKL--ELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADI 478
L + ++L L Q++ + A W+ + + + + G + E KK E + ++
Sbjct: 148 LEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVEL 207
Query: 479 AAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQ 538
A E RV V + A A E + D+ + ++++ V W L GL R+ L LQ
Sbjct: 208 VAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQ 267
Query: 539 KVFQEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAA 598
+ +++ + W++E + L S + G+ LV ++ L H LE ++A S++V+ L A A
Sbjct: 268 RFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKA 327
Query: 599 LRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAES 658
+L P D I + ++ A R +L+A+ + +E
Sbjct: 328 ---EKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSG 384
Query: 659 WARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQA 718
W +K AA A T D++ LL +H+ + E+ Q A
Sbjct: 385 WMNEKT----------AAINADELPT-----DVAGGEVLLDRHQQHKHEIDSYDDRFQSA 429
Query: 719 LRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQF 778
G++LV A +D V E+ W L E R R+ ++ H F
Sbjct: 430 DETGQDLVNAN---HEASDEVR-----EKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
Query: 779 GADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLAT 838
D + + W+ D G+ S+ L ++H A + + +
Sbjct: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
Query: 839 L-GGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWI 897
L G + A++ ++ + E AA RR+ L+++L + +++ + + WI
Sbjct: 542 LIGDDHYDSENIKAIRDGLLARRD---ALREKAATRRRLLKESLLLQKLYEDSDDLKNWI 598
Query: 898 GEKEQWLLSMRVPDSLDDVEVVQHRFES---LDQEMNSLMGRVLDVNHTVQELVEGGHPS 954
+K++ + + D++ ++ R + ++E+ ++ ++ T QE++EGGH +
Sbjct: 599 NKKKK----LADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYA 654
Query: 955 SDEVRSCQDHLNSRWNRIVELVEQR---KEEMSAVLLVENHVLEVAEVRAQVREKRRAVE 1011
SD V + + S W ++E +Q+ E + L EN+ ++ V E + E
Sbjct: 655 SDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDV-EWQVTSE 713
Query: 1012 SAPRAGGALQWRLSG---LEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGA 1068
+ +Q RL LE+A+ A + + L + AA E + + E L
Sbjct: 714 DYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773
Query: 1069 EWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADAL 1128
+ AL + + LQ D + W+ + +A + L L + L
Sbjct: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY--LGKDLIASKKL 831
Query: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWH-KLLGL 1187
L RH + E + E I ++ E G A D L + + L
Sbjct: 832 LNRHRVILENIASHEPRIQEITERGNKMV-----EEGHFAAEDVASRVKSLNQNMESLRA 886
Query: 1188 WEARREALVQAHI-YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLT 1246
ARR+ ++A++ +Q +L DL +A +R +E + E+ LK+H FL
Sbjct: 887 RAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLL 946
Query: 1247 TMELSQQKMQVAVQAAEGLLRQ--GNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQ 1304
+ M+ A +Q + G ++ V L + + ++ K D
Sbjct: 947 DLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRVMALYDFQARS---PREVTMKKGDV 1003
Query: 1305 LELQHFL-RDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKI 1363
L L + +D +++ H+ ++ A R + + R + + Q + E+I
Sbjct: 1004 LTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRREEPGNITQRQ---EQI 1060
Query: 1364 EREGQQLMQEKPELAASVRKKLGEIRQCWAE---LESTTQAKARQL-FEASKADQLVQSF 1419
E + + L+ E + ++ E + LE + KA E +L + F
Sbjct: 1061 ENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAENTGVELDDVWELQKKF 1120
Query: 1420 AELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLE 1479
E K L E +L+D++ D L
Sbjct: 1121 DEFQKDLNTNEPRLRDINKVADDLLFEGL-----------------------------LT 1151
Query: 1480 PASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAH-DLDDELAWVQERLPLA 1538
P ++ E + G L+ L + +R LL S +V H + DD ++++
Sbjct: 1152 PEGAQIRQELNSRWGS-----LQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQAL 1206
Query: 1539 MQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQ 1598
+ G+ L +VQ ++++G R++ G ++ + E A L+ E ++R +
Sbjct: 1207 SAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKME 1266
Query: 1599 LQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 1658
L AW L+ + R++ L+ A + + +++ W+ ++ S++ +D
Sbjct: 1267 LNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326
Query: 1659 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 1718
LL++H + +E + L L++ GH S +I ++ V L++ E+
Sbjct: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
Query: 1719 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 1778
R+ L+Q L ++E W+ +E S + + + L +K + +
Sbjct: 1387 RKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD-KSSLDSLEALMKKRDDL-DKAIT 1444
Query: 1779 AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHK 1838
A ++ + + LI H A +A + + W L + L L +
Sbjct: 1445 AQEGKITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQ 1504
Query: 1839 FFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVR-QL 1894
F+ D EL+ I E LP T E A+++QR + F H++ QV +
Sbjct: 1505 FYRDLEELEEWISE---MLP--TACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVI 1559
Query: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDL 1954
G + + + EA+ + +++ + W LL D ++ + RF++ +RD
Sbjct: 1560 NLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDF 1619
Query: 1955 LSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSA 2014
W+ + + D+ RD++S L+ HQ L+ E+ AR L L LL + +
Sbjct: 1620 EFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTF 1679
Query: 2015 MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSR 2074
D+I + D + R V E H E L++ + QF Q+ ++W+ + + S+
Sbjct: 1680 NVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQ 1739
Query: 2075 ELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ G + V+ L+++H+ A E ++ L EK+K
Sbjct: 1740 DYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNV--LDMAEKLK 1780
Score = 244 bits (623), Expect = 8e-64
Identities = 190/837 (22%), Positives = 367/837 (43%), Gaps = 9/837 (1%)
Query: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333
E+ QE +L + Q + R + QKL D LQ F RD +L WI EK+ + D +
Sbjct: 22 EEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY 81
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
ED + ++ +HQ+ AE+ + ++E+ ++ + + E+R W
Sbjct: 82 EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLWD 141
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQ 1453
L T K QL A K Q VQ A++ + + E+ V+ G D KK +
Sbjct: 142 LLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFE 201
Query: 1454 SMESQVEEWYREVGELQ--AQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLL 1511
+ ++ V E+ A A P L+ +QN V RL +R++ L
Sbjct: 202 DFQVELVAKEGRVVEVNQYANECAEENHP-DLPLIQSKQNEVNAAWERLRGLALQRQKAL 260
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
+ L + D+ + + W++E+ P+ + G L A + ++GL R + ++
Sbjct: 261 SNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKV 320
Query: 1572 EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
+E+ +A L +A ++ E L S+W +R A R + L A + ++ D
Sbjct: 321 KELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFD 380
Query: 1632 EVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMG 1691
E+ W+ E+ + +++ D LL +H Q + +++Y++ + L+
Sbjct: 381 ELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNAN 440
Query: 1692 HPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAG 1751
H S+++ + +D + AL EL +ER EQ + R +++ W++ +E
Sbjct: 441 HEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLE 500
Query: 1752 SPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG 1811
+ +LG L +K +F E A E++ V++ +LI H + + +DG
Sbjct: 501 NEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIRDG 559
Query: 1812 LNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSAS 1871
L L E TR +LL S L K + D+ +L+ I K+++L + + S
Sbjct: 560 LLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWI-NKKKKLADDEDYKDIQNLKS 618
Query: 1872 SMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHA-EAIASREQEVLQGWKELLSA 1930
+Q+ + FE +L + +Q+ +Q+ ++ + G +A + + +R EV W+ELL A
Sbjct: 619 RVQKQ-QVFEKELAVNKTQLENIQKTGQEM--IEGGHYASDNVTTRLSEVASLWEELLEA 675
Query: 1931 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTE 1990
+ + L+F + DL W++ + Q+ + D + ++ V+ + H L++
Sbjct: 676 TKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESA 735
Query: 1991 LEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
+ AR ++ +L + +I+A+ + L R E + E + L +L +
Sbjct: 736 VAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795
Query: 2051 HQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
++ +AW+ EP S LG + ++L+ RH + A+ E R +
Sbjct: 796 QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852
Score = 194 bits (492), Expect = 1e-48
Identities = 247/1268 (19%), Positives = 493/1268 (38%), Gaps = 67/1268 (5%)
Query: 845 AGPLVVALQVRVVEAEQ----LFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEK 900
+GP V+ + E Q + E A R Q L D+ + + WI EK
Sbjct: 13 SGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEK 72
Query: 901 EQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRS 960
L D + ++ + +SL+ E+ + + ++ T +E GH + +E ++
Sbjct: 73 VNILTDKSYEDPTN-IQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKA 131
Query: 961 CQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG-- 1018
+ L W+ ++EL ++ +++ L + +V E A++ + +K A+ ++ G
Sbjct: 132 HIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKE-AIATSVELGEDW 190
Query: 1019 ----ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALA 1074
L + + L A E R + + A AE + E+ A W L
Sbjct: 191 ERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLR 250
Query: 1075 SAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAA 1134
A +A++ A LQRF D+ + W ++ +E SE L ++ L H
Sbjct: 251 GLALQRQKALSNAANLQRFKRDVTEAIQW-IKEKEPVLTSED-YGKDLVASEGLFHSHKG 308
Query: 1135 LKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREA 1194
L+ + + + A +E L + ++ + E L W + L +R E
Sbjct: 309 LERNLAVMSDKVKELCAKAEKLTLSHPSDAPQ---IQEMKEDLVSSWEHIRALATSRYEK 365
Query: 1195 LVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQK 1254
L + Y F D + + + A++ ELP V E L +H+ ++ +
Sbjct: 366 LQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDR 425
Query: 1255 MQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQ-LELQHFLRD 1313
Q A + + L+ + ++ +E + +L+ N L + ++Q L+ F RD
Sbjct: 426 FQSADETGQDLVNANHEASDEVREKM-EILDNNWTALLELWDERHRQYEQCLDFHLFYRD 484
Query: 1314 CHELDGWI-HEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQ 1372
++D W+ ++ + + +H+ F +E + +++ +L+
Sbjct: 485 SEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIG 544
Query: 1373 EK---PELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM 1429
+ E ++R L R E +T + R L E+ +L + +L K ++
Sbjct: 545 DDHYDSENIKAIRDGLLARRDALREKAAT---RRRLLKESLLLQKLYEDSDDL-KNWINK 600
Query: 1430 ESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPA--SKELVG 1487
+ +L D + D+ + S+++K Q E ++ ++ +Q +T +E + + V
Sbjct: 601 KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQ-KTGQEMIEGGHYASDNVT 659
Query: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
R + V LLE +++ L + + Q ++ +D W+++ + G GL
Sbjct: 660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGL 719
Query: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLR 1607
VQ ++K+ L + A +++ + + A + P+++ +R E L + L+
Sbjct: 720 AEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALK 779
Query: 1608 EAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLE 1667
E R++ L ++ D + EAW+ E E S GKD ++ +LL +H +
Sbjct: 780 EPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVIL 839
Query: 1668 QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQY 1727
+ + ++E I +++ + ++E GH +E ++ R +++ +L+ R+ LE
Sbjct: 840 ENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANV 899
Query: 1728 WLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAV 1787
Q + E E WI EKE + + G D E L +K F + G A
Sbjct: 900 QFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALR 959
Query: 1788 NQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQ 1847
NQ C AA + E A +M + RE+ D L
Sbjct: 960 NQ----ANACQQQQAAPV--------EGVAGEQRVMALYDFQARSPREVTMKKGDVLTLL 1007
Query: 1848 GQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 1907
I + + + A +H + VR+L +
Sbjct: 1008 SSINKDWWK--------------------VEAADHQGIVPAVYVRRLAHDEFPMLPQRRR 1047
Query: 1908 EHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGA 1967
E I R++++ ++ LL E+ R + + + D+L W+ + A
Sbjct: 1048 EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI----QEKKA 1103
Query: 1968 ADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLG 2027
+ ++ V L + +L P L ++ LL + Q + +L
Sbjct: 1104 ENTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELN 1162
Query: 2028 TRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLI 2087
+R + D + L V F +EA + + L + + GS + V+ L
Sbjct: 1163 SRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQ 1222
Query: 2088 RRHEAFRK 2095
RRHE F +
Sbjct: 1223 RRHEGFER 1230
Score = 193 bits (490), Expect = 2e-48
Identities = 131/527 (24%), Positives = 256/527 (48%), Gaps = 10/527 (1%)
Query: 1589 AEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSED 1648
AE ++ +++ + + +E R Q L+ ++ ++ + D ++ W+ E+ ++ D
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILT--D 78
Query: 1649 KGKDEQSTLQ-LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDR 1707
K ++ + +Q +KH LE V+ +++L + MGH E+ ++
Sbjct: 79 KSYEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRH 138
Query: 1708 LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQE 1767
L+ L EL E+ L + Q ++ +++ WI +KE +A S ELG+D+E VL +
Sbjct: 139 LWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHK 198
Query: 1768 KFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 1827
KF +F E +A R+ VNQ +E E H + ++ +N AW L L R
Sbjct: 199 KFEDFQVEL-VAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQ 257
Query: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASS--MQRTLRAFEHDLQ 1885
+ L+ + L +F D E I+EK P LT+ + +S + + + E +L
Sbjct: 258 KALSNAANLQRFKRDVTEAIQWIKEKE---PVLTSEDYGKDLVASEGLFHSHKGLERNLA 314
Query: 1886 LLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL 1945
++ +V++L A +L + + A I +++++ W+ + + + +T
Sbjct: 315 VMSDKVKELCAKAEKLTLSHPSD-APQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYH 373
Query: 1946 RFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELG 2005
RF S +L WM+ + I A + P DV+ EVL++ HQ K E+++ + E G
Sbjct: 374 RFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETG 433
Query: 2006 RSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLT 2065
+ L+ +DE++ +++ L + E WD +Q L+ H F +++ D+W++
Sbjct: 434 QDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMS 493
Query: 2066 AQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
QE L++ +LG+S+ E L+++HE F +A A EE+ ++ + T
Sbjct: 494 RQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
Score = 165 bits (417), Expect = 6e-40
Identities = 158/771 (20%), Positives = 322/771 (41%), Gaps = 29/771 (3%)
Query: 1363 IEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAEL 1422
+E G +++ E A ++++ E+ + + + ++L ++ + +L
Sbjct: 10 VESSGPKVL----ETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDL 65
Query: 1423 DKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQ-AQTAALPLEPA 1481
K ++ + L D D + + +K QS+E++V+ R + EL+ + + +
Sbjct: 66 GKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHS 124
Query: 1482 SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT 1541
+ E + LLE E+ LL + + Q + D L W+ ++ +A
Sbjct: 125 AHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSV 184
Query: 1542 ERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS 1601
E G + + KK + + E+ A R+ EV + A A P+ ++ ++ +
Sbjct: 185 ELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNA 244
Query: 1602 AWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLK 1661
AW LR A +RQ+ L A ++++ DV E W+ E+E ++ SED GKD ++ L
Sbjct: 245 AWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFH 304
Query: 1662 KHLQLEQGVENYEESIAQLSRQCRALLEMGHP-DSEQISRRQSQVDRLYVALKELGEERR 1720
H LE+ + + + +L + L + HP D+ QI + + + ++ L R
Sbjct: 305 SHKGLERNLAVMSDKVKELCAKAEKLT-LSHPSDAPQIQEMKEDLVSSWEHIRALATSRY 363
Query: 1721 VALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAG 1780
L+ YW ++ S EL W+ EK + EL D VL ++ + E
Sbjct: 364 EKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYD 423
Query: 1781 RERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFF 1840
+R + ++ +L+ H A+ + E + L+ W LLEL R + + H F+
Sbjct: 424 -DRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY 482
Query: 1841 SDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQ 1900
D+ ++ + + L + S S + L+ E + +Q ++
Sbjct: 483 RDSEQVDSWMSRQEAFLEN----EDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKT 538
Query: 1901 LRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADAL--------RFHSQVR 1952
+ +H ++ E ++ ++ L A DA ++T L + +
Sbjct: 539 ATKLIGDDHYDS------ENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSD 592
Query: 1953 DLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNK 2012
DL +W++ ++ + +D+ +++ + Q + EL +L Q+ G+ ++
Sbjct: 593 DLKNWINK-KKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGG 651
Query: 2013 SAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQ 2072
+D + +L ++ + EE+ E + L + + QF A WL E +
Sbjct: 652 HYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVT 711
Query: 2073 SRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT-IEKIKAEQSK 2122
S + G + EV+ +R+H A AA +++ L L E+I SK
Sbjct: 712 SEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 307 bits (787), Expect = 8e-83
Identities = 244/811 (30%), Positives = 381/811 (46%), Gaps = 79/811 (9%)
Query: 50 SRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPR 109
+ I +L DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR
Sbjct: 9 NEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR 68
Query: 110 PTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVI 169
+GRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I
Sbjct: 69 E-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI 127
Query: 170 KIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDF 229
++ + E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D
Sbjct: 128 QVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDM 185
Query: 230 SKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKA 289
+K+ + NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++
Sbjct: 186 NKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPD 245
Query: 290 LAVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQ 349
+ +G R E+ + Y EL LL W+ ++F +S ++
Sbjct: 246 VQ-DGVRAN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWS 297
Query: 350 AFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKA 409
F + +E P K +K + + S++ ++A +L VP G D++K WG+L A
Sbjct: 298 QFLKFKEMELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVA 354
Query: 410 EHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMK 469
ERE LR+E R E L+ + + + + E LN+ L+ D L A +
Sbjct: 355 ILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQ 411
Query: 470 KHEAIEADIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LT 521
+ +E D+ + ++ + Q L + Y + R+ + ++ ++ L L
Sbjct: 412 RAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLK 471
Query: 522 GLVGARRTRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEAD 571
V A T++ Q + LQ V + + Y+ D W+EE Q ++ E G L +
Sbjct: 472 AGVAAPATQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVE 530
Query: 572 DLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQE 631
L H L I ++E + + Q+ CL L
Sbjct: 531 AQLGSHRGLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDL 577
Query: 632 QAAR----RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGG 687
Q A+ +A L + SL + + + W +KE G
Sbjct: 578 QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWS 623
Query: 688 AHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAER 747
+ + TA+ + L EL + +++ G+ L+ P ++
Sbjct: 624 DRNTNMTAK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ------- 675
Query: 748 AASARRRWQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHD 804
A+ + +W + + E L+E A QF +D+ +G L L++A R + D
Sbjct: 676 -AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 734
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQ 835
L + + ++ ++G +SGL ++
Sbjct: 735 VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 765
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1081 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1140
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1141 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1189
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1190 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1247
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1248 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1295
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1296 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1409
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1756
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1757 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1813
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1873 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2100
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2156
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2157 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2272 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2387
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
Query: 2325 DI 2326
+
Sbjct: 2448 QL 2449
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 994 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1042
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1043 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1102
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1103 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1150
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1210
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1270
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1326
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1387 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1534
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1535 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1592
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1651
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1712 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1765
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1936
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2053
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2112
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2165
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2217
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2218 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2385
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2386 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2428
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2429 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2485 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2543 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2599
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 503 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 562
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 563 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 614
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 615 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 674
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 675 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 733
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 734 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 767
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 768 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 797
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 798 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 857
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 858 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 903
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 904 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 963
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 964 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1013
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1014 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1073 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1127 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1186
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1187 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1246
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1305
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1364
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1365 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1418
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1419 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1477
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1536
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1537 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1646
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1704
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1705 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1762
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1763 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1822
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1823 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1940
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 1994
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 1995 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2051
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2139
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1161
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1222 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1270
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1271 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1312
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1361
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1418
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1419 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1468
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1469 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1521
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1575
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1633
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1694 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1747
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1748 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1775
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1776 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1829
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1877
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1878 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1930 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2332
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2333 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2378
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2379 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2435 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2542 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2602 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2637
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1206 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1317
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1318 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1363
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1364 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1410
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1411 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1470
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1471 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1529
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1530 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1581 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1638
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1639 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1691
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1746
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1747 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1805
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1806 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1865
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 1866 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 1923
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 1924 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1983
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2100
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2341 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2397
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2398 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2509
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2510 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2560
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2561 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2608
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2609 DALDGPAAEAEPE 2621
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1549
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1550 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1582
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1583 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1638 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1695 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1728
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1779
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1780 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1822
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1823 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1863
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1864 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1922
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 1923 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 1965
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2025
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2075
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2256 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2315
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2316 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2356
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2357 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2399
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2400 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2451
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2486
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2487 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2526
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2527 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2583
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2584 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2643
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2644 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2677
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 360 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 419
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 420 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 478
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 479 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 531
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 532 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 587
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 588 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 645
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 646 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 705
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 706 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 765
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 766 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 824
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 825 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 882
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 883 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 929
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 930 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 989
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 990 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1048
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1049 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1108
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1109 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1227
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1346
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1347 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1523
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1524 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1574
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1575 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1629
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1630 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1686
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1687 LAAEQELIRLRAETEQGEQQRQLLEEEL 1714
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 271 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 329
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 330 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 377
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 378 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 412
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 413 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 458
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 459 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 510
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 511 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 559
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 560 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 614
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 615 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 671
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 672 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 723
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 724 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 774
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 775 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 834
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 835 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 887
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 888 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 940
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 941 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1000
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1059
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1120 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1173
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1174 DVRQRELEQ 1182
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1534 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1651
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1652 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1710
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1767
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1825
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1885
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 1946 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 2005 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2123 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2177
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2178 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2224 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2273
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2274 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2334 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2389
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2390 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2434
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2490
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2491 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2546
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2547 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2606
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2607 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2663
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2664 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2719
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2720 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2774
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2775 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2811
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 219 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 275
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 276 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 335
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 336 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 394
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 395 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 454
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 455 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 510
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 511 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 563
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 564 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 614
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 306 bits (784), Expect = 2e-82
Identities = 243/806 (30%), Positives = 379/806 (47%), Gaps = 79/806 (9%)
Query: 55 LADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGR 114
+ADER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GR
Sbjct: 63 IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGR 121
Query: 115 MRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETE 174
MR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 122 MRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQ 181
Query: 175 DNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTK 234
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 182 S--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYR 239
Query: 235 SNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEG 294
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G
Sbjct: 240 QTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DG 298
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
R E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 299 VRAN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKF 351
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 352 KEMELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILERE 408
Query: 415 AALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAI 474
LR+E R E L+ + + + + E LN+ L+ D L A ++ +
Sbjct: 409 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEV 465
Query: 475 EADIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGA 526
E D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 466 ERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAA 525
Query: 527 RRTRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQK 576
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L
Sbjct: 526 PATQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 584
Query: 577 HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR- 635
H L I ++E + + Q+ CL L Q A+
Sbjct: 585 HRGLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKL 631
Query: 636 ---RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLS 692
+A L + SL + + + W +KE G + +
Sbjct: 632 LNSSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTN 677
Query: 693 STARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASAR 752
TA+ + L EL + +++ G+ L+ P ++ A+ +
Sbjct: 678 MTAK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQ 728
Query: 753 RRWQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSR 809
+W + + E L+E A QF +D+ +G L L++A R + D
Sbjct: 729 TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLE 788
Query: 810 RLARQHRALTGEVEAHRGPVSGLRRQ 835
L + + ++ ++G +SGL ++
Sbjct: 789 DLLQDAQDEKEQLNEYKGHLSGLAKR 814
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1130 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1189
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1190 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1238
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1239 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1296
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1297 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1344
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1345 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1401
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1402 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1458
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1578
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1805
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1806 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1862
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1922 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2149
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2205
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2206 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2260
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2321 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2379
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2380 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2436
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2496
Query: 2325 DI 2326
+
Sbjct: 2497 QL 2498
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 1043 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1091
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1092 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1151
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1152 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1199
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1200 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1259
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1260 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1319
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1375
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1376 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1435
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1436 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1484
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1485 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1583
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1584 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1641
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1642 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1700
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1761 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1814
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1874
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1985
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2102
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2103 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2161
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2162 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2214
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2215 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2266
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2267 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2434
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2435 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2477
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2478 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2534 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2591
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2592 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2648
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2649 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2687
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 552 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 611
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 612 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 663
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 664 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 723
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 724 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 782
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 783 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 816
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 817 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 846
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 847 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 906
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 907 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 952
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 953 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 1012
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 1013 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1062
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1063 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1121
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1122 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1175
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1176 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1235
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1236 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1295
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1354
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1413
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1414 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1467
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1468 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1526
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1527 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1585
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1586 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1695
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1753
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1754 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1811
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1812 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1871
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1872 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1989
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 2043
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 2044 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2100
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2188
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1271 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1319
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1320 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1361
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1362 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1410
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1467
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1468 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1517
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1518 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1570
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1624
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1682
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1743 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1796
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1797 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1824
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1825 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1878
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1926
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1927 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1979 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2092
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2206
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2207 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2266
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2267 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2381
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2382 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2427
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2428 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2483
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2484 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2591 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2651 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2686
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1255 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1366
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1367 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1412
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1413 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1459
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1460 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1519
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1520 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1578
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1579 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1630 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1687
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1688 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1740
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1795
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1796 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1854
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1855 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1914
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 1915 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 1972
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 1973 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2032
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2092
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2149
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2390 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2446
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2447 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2558
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2559 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2609
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2610 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2657
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2658 DALDGPAAEAEPE 2670
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1543 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1598
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1599 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1631
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1632 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1687 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1744 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1777
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1778 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1828
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1829 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1871
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1872 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1912
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1913 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1971
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 1972 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 2014
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2074
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2075 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2124
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2125 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2185 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2244
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2245 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2305 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2364
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2365 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2405
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2406 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2448
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2449 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2500
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2535
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2536 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2575
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2576 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2632
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2633 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2692
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2693 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2726
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 409 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 468
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 469 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 527
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 528 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 580
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 581 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 636
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 637 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 694
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 695 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 754
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 755 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 814
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 815 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 873
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 874 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 931
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 932 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 978
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 979 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1038
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 1039 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1097
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1098 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1157
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1158 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1216
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1217 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1276
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1277 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1337 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1395
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1396 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1572
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1573 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1623
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1624 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1678
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1679 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1735
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1736 LAAEQELIRLRAETEQGEQQRQLLEEEL 1763
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 320 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 378
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 379 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 426
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 427 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 461
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 462 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 507
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 508 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 559
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 560 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 608
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 609 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 663
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 664 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 720
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 721 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 772
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 773 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 823
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 824 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 883
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 884 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 936
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 937 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 989
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 990 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1049
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 1050 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1108
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1109 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1168
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1169 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1222
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1223 DVRQRELEQ 1231
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1583 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1643 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1700
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1701 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1759
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1816
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1874
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1875 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1934
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 1995 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2053
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 2054 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2111
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2112 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2171
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2172 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2226
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2227 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2273 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2322
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2323 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2383 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2438
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2439 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2483
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2539
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2540 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2595
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2596 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2655
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2656 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2712
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2713 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2768
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2769 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2823
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2824 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2860
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 268 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 324
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 325 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 384
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 385 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 443
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 444 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 503
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 504 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 559
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 560 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 612
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 613 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 663
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 306 bits (783), Expect = 2e-82
Identities = 243/809 (30%), Positives = 380/809 (46%), Gaps = 79/809 (9%)
Query: 52 IKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPT 111
+K + DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR
Sbjct: 1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE- 59
Query: 112 RGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKI 171
+GRMR H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++
Sbjct: 60 KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV 119
Query: 172 ETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSK 231
+ E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K
Sbjct: 120 SGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNK 177
Query: 232 LTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALA 291
+ + NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ +
Sbjct: 178 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 237
Query: 292 VEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAF 351
+G R E+ + Y EL LL W+ ++F +S ++ F
Sbjct: 238 -DGVRAN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQF 289
Query: 352 TAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEH 411
+ +E P K +K + + S++ ++A +L VP G D++K WG+L A
Sbjct: 290 LKFKEMELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAIL 346
Query: 412 EREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKH 471
ERE LR+E R E L+ + + + + E LN+ L+ D L A ++
Sbjct: 347 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRA 403
Query: 472 EAIEADIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGL 523
+E D+ + ++ + Q L + Y + R+ + ++ ++ L L
Sbjct: 404 GEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG 463
Query: 524 VGARRTRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDL 573
V A T++ Q + LQ V + + Y+ D W+EE Q ++ E G L +
Sbjct: 464 VAAPATQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQ 522
Query: 574 LQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQA 633
L H L I ++E + + Q+ CL L Q
Sbjct: 523 LGSHRGLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQY 569
Query: 634 AR----RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAH 689
A+ +A L + SL + + + W +KE G
Sbjct: 570 AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDR 615
Query: 690 DLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAA 749
+ + TA+ + L EL + +++ G+ L+ P ++ A
Sbjct: 616 NTNMTAK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------A 666
Query: 750 SARRRWQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEA 806
+ + +W + + E L+E A QF +D+ +G L L++A R + D
Sbjct: 667 ALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVT 726
Query: 807 SSRRLARQHRALTGEVEAHRGPVSGLRRQ 835
L + + ++ ++G +SGL ++
Sbjct: 727 RLEDLLQDAQDEKEQLNEYKGHLSGLAKR 755
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1071 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1130
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1131 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1179
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1180 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1237
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1238 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1285
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1286 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1342
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1343 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1399
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1519
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1746
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1747 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1863 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1921
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2041
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2090
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2146
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2147 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2201
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2262 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2320
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2377
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2437
Query: 2325 DI 2326
+
Sbjct: 2438 QL 2439
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 984 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1032
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1033 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1092
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1093 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1140
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1141 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1200
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1201 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1260
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1316
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1317 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1376
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1377 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1425
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1524
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1525 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1582
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1583 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1641
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1642 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1702 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1755
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1815
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1926
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2043
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2044 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2102
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2103 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2155
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2207
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2208 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2375
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2376 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2418
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2419 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2474
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2475 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2532
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2533 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2589
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2590 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2628
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 493 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 552
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 553 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 604
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 605 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 664
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 665 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 723
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 724 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 757
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 758 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 787
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 788 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 847
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 848 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 893
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 894 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 953
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 954 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1003
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1004 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1062
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1063 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1116
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1117 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1176
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1177 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1236
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1295
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1354
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1355 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1408
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1409 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1467
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1468 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1526
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1527 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1636
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1694
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1695 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1752
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1753 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1812
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1813 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1930
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 1984
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 1985 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2041
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2129
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1151
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1152 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1211
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1212 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1260
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1261 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1302
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1303 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1351
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1408
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1409 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1458
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1459 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1511
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1565
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1623
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1684 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1737
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1738 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1765
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1766 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1819
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1867
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1868 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1920 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2148 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2207
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2322
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2323 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2368
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2369 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2424
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2425 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2471
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2472 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2531
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2532 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2591
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2592 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2627
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1196 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1250
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1251 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1307
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1308 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1353
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1354 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1400
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1401 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1460
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1461 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1519
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1520 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1571 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1628
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1629 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1681
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1736
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1737 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1795
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1796 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1855
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 1856 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 1913
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 1914 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1973
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2090
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2091 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2150
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2210
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2331 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2387
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2388 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2499
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2500 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2550
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2551 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2598
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2599 DALDGPAAEAEPE 2611
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1484 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1539
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1540 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1572
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1573 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1628 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1684
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1685 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1718
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1769
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1770 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1812
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1813 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1853
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1854 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1912
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 1913 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 1955
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2015
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2016 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2065
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2066 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2126 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2185
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2186 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2246 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2305
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2306 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2346
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2347 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2389
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2390 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2441
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2476
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2477 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2516
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2517 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2573
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2574 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2633
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2634 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2667
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 350 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 409
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 410 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 468
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 469 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 521
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 522 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 577
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 578 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 635
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 636 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 695
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 696 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 755
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 756 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 814
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 815 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 872
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 873 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 919
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 920 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 979
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 980 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1038
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1039 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1098
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1099 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1157
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1158 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1217
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1218 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1336
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1337 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1454 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1513
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1514 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1564
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1565 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1619
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1620 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1676
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1677 LAAEQELIRLRAETEQGEQQRQLLEEEL 1704
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 261 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 319
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 320 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 367
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 368 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 402
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 403 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 448
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 449 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 500
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 501 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 549
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 550 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 604
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 605 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 661
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 662 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 713
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 714 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 764
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 765 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 824
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 825 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 877
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 878 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 930
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 931 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 990
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 991 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1049
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1050 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1109
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1110 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1163
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1164 DVRQRELEQ 1172
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1524 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1584 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1641
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1642 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1700
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1757
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1815
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1875
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 1936 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 1994
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 1995 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2052
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2053 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2112
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2113 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2167
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2168 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2214 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2263
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2264 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2324 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2379
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2380 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2424
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2480
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2481 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2536
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2537 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2596
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2597 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2653
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2654 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2709
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2710 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2764
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2765 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2801
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 209 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 265
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 266 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 325
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 326 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 384
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 385 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 444
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 445 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 500
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 501 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 553
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 554 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 604
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 304 bits (778), Expect = 8e-82
Identities = 242/804 (30%), Positives = 377/804 (46%), Gaps = 79/804 (9%)
Query: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116
DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GRMR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356
E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 274 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
LR+E R E L+ + + + + E LN+ L+ D L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528
D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L H
Sbjct: 501 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 559
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635
L I ++E + + Q+ CL L Q A+
Sbjct: 560 GLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 606
Query: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
+A L + SL + + + W +KE G + + T
Sbjct: 607 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 652
Query: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
A+ + L EL + +++ G+ L+ P ++ A+ + +
Sbjct: 653 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 703
Query: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811
W + + E L+E A QF +D+ +G L L++A R + D L
Sbjct: 704 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 763
Query: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835
+ + ++ ++G +SGL ++
Sbjct: 764 LQDAQDEKEQLNEYKGHLSGLAKR 787
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1103 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1162
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1163 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1211
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1317
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1318 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1431
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1778
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1779 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1895 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2122
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2178
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2179 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2294 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 2325 DI 2326
+
Sbjct: 2470 QL 2471
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 1016 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1064
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1065 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1124
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1125 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1172
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1348
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1409 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1556
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1557 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1673
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1734 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1787
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1958
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2075
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2134
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2187
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2239
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2240 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2407
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2408 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2450
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2507 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2565 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2621
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 525 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 585 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 636
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 637 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 696
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 697 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 755
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 756 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 789
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 790 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 819
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 820 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 879
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 880 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 925
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 926 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 985
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 986 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1035
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1036 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1386
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1387 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1440
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1499
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1558
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1668
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1726
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1727 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1845 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 2016
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 2017 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2073
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2161
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1244 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1292
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1293 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1334
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1383
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1441 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1490
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1543
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1655
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1716 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1770 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1797
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1798 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1851
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1899
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1900 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1952 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2354
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2355 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2400
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2401 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2457 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2624 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2659
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1228 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1339
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1340 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1385
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1386 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1432
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1551
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1552 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1603 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1661 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1713
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1768
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1769 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 1945
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2122
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2363 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2419
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2420 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2531
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2532 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2582
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2583 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2630
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2631 DALDGPAAEAEPE 2643
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1571
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1572 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1604
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1605 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1660 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1717 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1750
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1801
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1802 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1844
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1845 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1885
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1944
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 1945 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 1987
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2097
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2338 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2378
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2379 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2421
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2422 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2473
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2508
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2509 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2548
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2549 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2605
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2666 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2699
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 382 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 441
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 442 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 500
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 501 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 553
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 554 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 609
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 610 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 668 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 728 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 787
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 788 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 846
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 904
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 905 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 951
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 952 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1011
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1070
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1130
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1131 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1368
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1596
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1597 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1708
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 293 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 351
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 352 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 399
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 400 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 434
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 435 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 480
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 481 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 532
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 581
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 582 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 636
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 637 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 693
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 745
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 796
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 797 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 856
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 857 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 909
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 910 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 962
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 963 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1022
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1081
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1142 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1195
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1196 DVRQRELEQ 1204
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1789
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1847
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 1968 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 2027 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2145 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2200 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2246 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2295
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2356 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2411
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2412 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2456
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2568
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2628
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2629 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2685
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2686 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2741
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2742 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2796
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2833
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 241 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 297
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 298 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 357
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 358 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 416
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 417 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 476
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 477 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 532
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 585
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 586 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 304 bits (778), Expect = 8e-82
Identities = 242/804 (30%), Positives = 377/804 (46%), Gaps = 79/804 (9%)
Query: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116
DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GRMR
Sbjct: 42 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 100
Query: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 101 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 159
Query: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 160 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 218
Query: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G R
Sbjct: 219 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 277
Query: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356
E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 278 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 330
Query: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 331 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 387
Query: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
LR+E R E L+ + + + + E LN+ L+ D L A ++ +E
Sbjct: 388 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 444
Query: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528
D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 445 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 504
Query: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L H
Sbjct: 505 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 563
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635
L I ++E + + Q+ CL L Q A+
Sbjct: 564 GLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 610
Query: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
+A L + SL + + + W +KE G + + T
Sbjct: 611 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 656
Query: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
A+ + L EL + +++ G+ L+ P ++ A+ + +
Sbjct: 657 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 707
Query: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811
W + + E L+E A QF +D+ +G L L++A R + D L
Sbjct: 708 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 767
Query: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835
+ + ++ ++G +SGL ++
Sbjct: 768 LQDAQDEKEQLNEYKGHLSGLAKR 791
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1107 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1166
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1167 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1215
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1216 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1273
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1274 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1321
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1322 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1378
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1379 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1435
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1555
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1782
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1783 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1839
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1899 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1957
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2077
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2126
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2182
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2183 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2237
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2298 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2356
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2413
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2473
Query: 2325 DI 2326
+
Sbjct: 2474 QL 2475
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 1020 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1068
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1069 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1128
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1129 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1176
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1177 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1236
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1237 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1296
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1352
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1353 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1412
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1413 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1461
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1560
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1561 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1618
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1619 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1677
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1678 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1738 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1791
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1851
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1962
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2079
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2080 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2138
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2139 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2191
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2243
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2244 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2411
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2412 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2454
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2455 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2510
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2511 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2569 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2625
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2626 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2664
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 529 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 588
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 589 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 640
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 641 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 700
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 701 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 759
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 760 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 793
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 794 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 823
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 824 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 883
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 884 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 929
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 930 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 989
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 990 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1039
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1040 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1098
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1099 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1152
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1153 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1212
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1213 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1272
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1331
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1390
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1391 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1444
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1445 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1503
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1504 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1562
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1563 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1672
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1730
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1731 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1788
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1789 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1848
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1849 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1966
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 2020
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 2021 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2077
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2165
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1248 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1296
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1297 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1338
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1339 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1387
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1444
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1445 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1494
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1495 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1547
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1601
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1659
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1720 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1773
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1774 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1801
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1802 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1855
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1903
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1904 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1956 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2184 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2243
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2358
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2359 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2404
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2405 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2461 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2507
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2508 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2567
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2568 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2627
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2628 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2663
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1232 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1286
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1287 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1343
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1344 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1389
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1390 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1436
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1437 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1496
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1497 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1555
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1556 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1607 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1664
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1665 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1717
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1772
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1773 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1831
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1832 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1891
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 1892 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 1949
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 1950 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2009
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2126
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2127 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2367 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2423
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2424 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2535
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2536 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2586
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2587 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2634
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2635 DALDGPAAEAEPE 2647
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1520 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1575
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1576 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1608
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1609 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1664 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1720
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1721 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1754
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1805
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1806 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1848
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1849 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1889
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1890 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1948
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 1949 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 1991
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2051
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2052 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2101
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2102 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2162 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2221
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2222 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2282 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2342 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2382
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2383 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2425
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2426 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2477
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2512
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2513 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2552
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2553 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2609
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2610 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2669
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2670 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2703
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 386 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 445
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 446 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 504
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 505 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 557
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 558 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 613
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 614 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 671
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 672 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 731
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 732 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 791
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 792 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 850
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 851 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 908
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 909 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 955
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 956 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1015
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 1016 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1074
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1075 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1134
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1135 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1193
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1194 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1253
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1254 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1372
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1373 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1490 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1549
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1550 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1600
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1601 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1655
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1656 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1712
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEEL 1740
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 297 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 355
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 356 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 403
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 404 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 438
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 439 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 484
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 485 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 536
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 537 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 585
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 586 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 640
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 641 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 697
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 698 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 749
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 750 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 800
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 801 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 860
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 861 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 913
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 914 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 966
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 967 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1026
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 1027 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1085
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1086 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1145
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1146 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1199
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1200 DVRQRELEQ 1208
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1560 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1620 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1677
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1678 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1736
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1793
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1851
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1911
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 1972 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2030
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 2031 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2088
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2089 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2148
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2149 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2203
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2204 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2250 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2299
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2300 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2360 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2415
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2416 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2460
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2516
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2517 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2572
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2573 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2632
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2633 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2689
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2690 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2745
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2746 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2800
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2801 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2837
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 245 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 301
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 302 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 361
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 362 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 420
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 421 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 480
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 481 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 536
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 537 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 589
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 590 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 640
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 304 bits (778), Expect = 8e-82
Identities = 242/804 (30%), Positives = 377/804 (46%), Gaps = 79/804 (9%)
Query: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116
DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GRMR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356
E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 274 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
LR+E R E L+ + + + + E LN+ L+ D L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528
D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 441 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 500
Query: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L H
Sbjct: 501 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 559
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635
L I ++E + + Q+ CL L Q A+
Sbjct: 560 GLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 606
Query: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
+A L + SL + + + W +KE G + + T
Sbjct: 607 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 652
Query: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
A+ + L EL + +++ G+ L+ P ++ A+ + +
Sbjct: 653 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 703
Query: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811
W + + E L+E A QF +D+ +G L L++A R + D L
Sbjct: 704 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 763
Query: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835
+ + ++ ++G +SGL ++
Sbjct: 764 LQDAQDEKEQLNEYKGHLSGLAKR 787
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1103 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1162
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1163 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1211
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1270 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1317
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1318 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1374
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1375 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1431
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1778
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1779 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1895 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2122
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2178
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2179 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2233
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2294 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2352
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2409
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2469
Query: 2325 DI 2326
+
Sbjct: 2470 QL 2471
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 1016 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1064
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1065 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1124
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1125 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1172
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1232
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1233 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1292
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1348
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1349 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1408
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1409 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1556
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1557 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1614
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1615 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1673
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1734 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1787
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1847
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1958
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2075
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2076 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2134
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2135 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2187
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2239
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2240 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2407
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2408 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2450
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2451 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2507 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2565 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2621
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2622 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2660
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 525 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 584
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 585 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 636
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 637 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 696
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 697 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 755
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 756 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 789
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 790 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 819
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 820 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 879
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 880 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 925
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 926 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 985
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 986 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1035
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1036 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1094
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1095 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1148
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1149 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1208
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1209 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1268
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1386
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1387 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1440
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1499
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1500 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1558
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1668
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1726
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1727 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1785 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1844
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1845 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1962
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 2016
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 2017 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2073
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2161
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1244 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1292
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1293 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1334
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1335 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1383
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1440
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1441 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1490
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1543
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1655
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1716 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1769
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1770 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1797
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1798 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1851
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1899
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1900 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1952 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2180 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2239
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2354
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2355 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2400
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2401 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2457 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2503
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2504 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2563
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2564 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2623
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2624 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2659
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1228 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1282
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1283 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1339
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1340 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1385
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1386 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1432
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1551
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1552 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1603 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1660
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1661 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1713
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1768
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1769 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1827
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1828 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1887
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 1945
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 1946 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2005
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2122
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2123 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2363 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2419
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2420 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2531
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2532 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2582
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2583 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2630
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2631 DALDGPAAEAEPE 2643
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1516 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1571
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1572 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1604
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1605 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1660 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1717 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1750
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1801
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1802 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1844
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1845 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1885
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1886 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1944
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 1945 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 1987
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2047
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2048 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2097
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2098 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2158 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2217
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2338 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2378
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2379 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2421
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2422 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2473
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2508
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2509 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2548
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2549 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2605
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2666 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2699
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 382 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 441
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 442 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 500
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 501 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 553
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 554 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 609
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 610 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 668 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 728 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 787
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 788 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 846
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 847 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 904
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 905 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 951
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 952 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1011
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 1012 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1070
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1130
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1131 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1189
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1190 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1249
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1250 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1368
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1369 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1596
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1597 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1651
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1652 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1708
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEEL 1736
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 293 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 351
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 352 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 399
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 400 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 434
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 435 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 480
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 481 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 532
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 581
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 582 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 636
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 637 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 693
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 694 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 745
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 746 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 796
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 797 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 856
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 857 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 909
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 910 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 962
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 963 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1022
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 1023 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1081
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1082 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1141
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1142 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1195
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1196 DVRQRELEQ 1204
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1616 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1673
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1789
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1847
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1907
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 1968 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 2027 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2084
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2085 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2144
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2145 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2199
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2200 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2246 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2295
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2296 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2356 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2411
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2412 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2456
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2512
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2513 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2568
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2569 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2628
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2629 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2685
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2686 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2741
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2742 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2796
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2833
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 241 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 297
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 298 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 357
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 358 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 416
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 417 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 476
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 477 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 532
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 585
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 586 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 304 bits (778), Expect = 8e-82
Identities = 242/804 (30%), Positives = 377/804 (46%), Gaps = 79/804 (9%)
Query: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116
DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GRMR
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233
Query: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292
Query: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351
Query: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G R
Sbjct: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410
Query: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356
E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 411 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463
Query: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 464 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 520
Query: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
LR+E R E L+ + + + + E LN+ L+ D L A ++ +E
Sbjct: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577
Query: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528
D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637
Query: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L H
Sbjct: 638 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 696
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635
L I ++E + + Q+ CL L Q A+
Sbjct: 697 GLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 743
Query: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
+A L + SL + + + W +KE G + + T
Sbjct: 744 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 789
Query: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
A+ + L EL + +++ G+ L+ P ++ A+ + +
Sbjct: 790 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 840
Query: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811
W + + E L+E A QF +D+ +G L L++A R + D L
Sbjct: 841 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 900
Query: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835
+ + ++ ++G +SGL ++
Sbjct: 901 LQDAQDEKEQLNEYKGHLSGLAKR 924
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1240 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1299
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1300 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1348
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1349 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1406
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1407 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1454
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1455 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1568
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1915
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1916 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 2032 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2259
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2315
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2316 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2431 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2546
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606
Query: 2325 DI 2326
+
Sbjct: 2607 QL 2608
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 1153 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1201
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1202 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1261
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1262 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1309
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1369
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1429
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1485
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1546 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1594
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1693
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1694 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1751
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1810
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1871 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1924
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 2095
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2212
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2271
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2324
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2376
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2377 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2544
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2545 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2587
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2588 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2644 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2702 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2758
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 662 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 721
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 722 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 773
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 774 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 833
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 834 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 892
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 893 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 926
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 927 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 956
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 957 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 1016
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 1017 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 1062
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 1063 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 1122
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 1123 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1172
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1173 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1232 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1286 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1345
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1346 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1405
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1464
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1523
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1524 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1577
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1578 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1636
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1695
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1696 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1805
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1863
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1864 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1921
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1922 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1981
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1982 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 2099
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 2153
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 2154 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2210
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2298
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1381 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1429
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1430 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1471
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1520
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1577
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1578 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1627
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1628 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1680
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1734
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1792
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1853 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1907 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1934
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1935 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1988
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 2036
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 2037 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 2089 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2491
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2492 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2537
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2538 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2594 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2761 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2796
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1365 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1419
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1420 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1476
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1477 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1522
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1523 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1569
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1570 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1629
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1630 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1688
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1689 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1740 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1797
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1798 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1850
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1905
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1906 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1964
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1965 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 2024
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 2025 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 2082
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 2083 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 2142
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2259
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2319
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2379
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2500 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2556
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2557 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2668
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2669 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2719
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2720 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2767
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2768 DALDGPAAEAEPE 2780
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1708
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1709 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1741
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1742 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1797 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1854 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1887
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1938
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1939 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1981
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1982 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 2022
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 2023 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 2081
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 2082 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 2124
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2184
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2234
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2415 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2475 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2515
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2516 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2558
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2559 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2610
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2645
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2646 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2685
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2686 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2742
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2743 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2802
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2803 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2836
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 519 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 578
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 579 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 637
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 638 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 690
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 691 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 746
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 747 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 865 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 924
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 925 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 983
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 984 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 1041
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 1042 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 1088
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 1089 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1148
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 1149 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1207
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1208 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1267
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1268 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1327 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1386
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1387 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1505
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1506 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1682
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1683 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1733
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1734 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1788
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1789 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1845
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1846 LAAEQELIRLRAETEQGEQQRQLLEEEL 1873
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 430 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 488
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 489 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 536
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 537 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 571
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 572 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 617
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 618 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 669
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 670 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 718
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 719 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 773
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 774 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 830
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 831 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 882
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 883 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 933
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 934 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 993
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 994 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 1046
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 1047 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 1099
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 1100 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1159
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1218
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1279 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1332
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1333 DVRQRELEQ 1341
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1693 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1810
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1811 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1869
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1926
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1984
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 2044
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 2105 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2163
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 2164 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2282 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2336
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2337 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2383 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2432
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2433 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2493 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2548
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2549 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2593
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2649
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2650 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2705
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2706 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2765
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2766 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2822
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2823 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2878
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2879 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2933
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2934 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2970
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 378 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 434
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 435 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 494
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 495 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 553
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 554 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 613
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 614 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 669
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 670 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 722
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 723 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 773
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 304 bits (778), Expect = 8e-82
Identities = 242/804 (30%), Positives = 377/804 (46%), Gaps = 79/804 (9%)
Query: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116
DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GRMR
Sbjct: 24 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 82
Query: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 83 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 141
Query: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 142 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 200
Query: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G R
Sbjct: 201 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 259
Query: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356
E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 260 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 312
Query: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 313 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 369
Query: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
LR+E R E L+ + + + + E LN+ L+ D L A ++ +E
Sbjct: 370 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 426
Query: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528
D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 427 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 486
Query: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L H
Sbjct: 487 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 545
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635
L I ++E + + Q+ CL L Q A+
Sbjct: 546 GLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 592
Query: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
+A L + SL + + + W +KE G + + T
Sbjct: 593 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 638
Query: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
A+ + L EL + +++ G+ L+ P ++ A+ + +
Sbjct: 639 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 689
Query: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811
W + + E L+E A QF +D+ +G L L++A R + D L
Sbjct: 690 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 749
Query: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835
+ + ++ ++G +SGL ++
Sbjct: 750 LQDAQDEKEQLNEYKGHLSGLAKR 773
Score = 122 bits (306), Expect = 5e-27
Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)
Query: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033
E++ +E++ V + E+ +A +++ R E+ AL+ L G + +
Sbjct: 1089 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1148
Query: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093
L+ R E + ER+ + A+L + W A+ + + GR R+
Sbjct: 1149 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1197
Query: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140
+ L A+L R QE PL +S L + ALL RH EE
Sbjct: 1198 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1255
Query: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
+ + Y + E L A+L P +A P ++ G E+++Q ++
Sbjct: 1256 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1303
Query: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257
LR L L +Q + L E E+ + R+ L +E + +K +
Sbjct: 1304 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1360
Query: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317
+A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E
Sbjct: 1361 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1417
Query: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369
+ + A + +R E+ ++ + L + EL + E+ E + +Q
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425
+E L V+ + RQ EL S +A+A E +A Q ++ E +++
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1537
Query: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477
L E + L+ + A + S+ +Q+E +E AQ
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1596
Query: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536
A ++ ER ER L R E RL L ++E+ Q E +E
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656
Query: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594
+ QAV+Q Q L ++ Q ++ L L LR+ + E R+
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716
Query: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653
LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1764
Query: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709
+ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+
Sbjct: 1765 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1821
Query: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768
L +GE R+ E + L + + L +AE E Q +H + ++E+
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817
SE + G+ + L Q+ +E++ + AAA AE + L +
Sbjct: 1881 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1939
Query: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868
E EL R + LAA E + ++ R + E+ R E
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928
+ ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Query: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988
S + R + A + R + ++ AA R V E L Q +
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2108
Query: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048
+ +AR ++L + + A QA L +K+ + ++H ++ +Q L
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2164
Query: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106
Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS
Sbjct: 2165 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2219
Query: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148
++ + K+KA + +L ++F + E +AA+ A L
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279
Query: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208
R E L A L +++ R + + E LQ + + E R++
Sbjct: 2280 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2338
Query: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268
A + A ET E R R + E + AE L + R E + ++EE A+R R +
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2395
Query: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324
+E E E A + + +E +R++ + ER + E+ + ++ +A L
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2455
Query: 2325 DI 2326
+
Sbjct: 2456 QL 2457
Score = 122 bits (305), Expect = 6e-27
Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 1002 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1050
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1051 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1110
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1111 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1158
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1159 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1218
Query: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835
D + R RQ +AL E+E H V +R Q
Sbjct: 1219 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1278
Query: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895
L + + + + + E L +E+ L Q+++ R E E
Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1334
Query: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951
+ E+++ R+ + +E + E+ Q ++ +QE V E
Sbjct: 1335 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1394
Query: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006
+ + RS Q+ L +Q ++ A + + E AE + ++R
Sbjct: 1395 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1443
Query: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066
R +E+ R G + L L A + E ++ EEA L + ++ R Q EL
Sbjct: 1444 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503
Query: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126
+ A A AA+ A+ A L+ ++A+EA L +A+
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1542
Query: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181
AR + E QR + + + A A A+L L A+ + E
Sbjct: 1543 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1600
Query: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237
+ AR EA + +QL LR QA V + + +A + AE E+ EA
Sbjct: 1601 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1659
Query: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281
K + EL++Q+++ Q AEG LR GEQ ++ +
Sbjct: 1660 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719
Query: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341
L + Q A Q Q+L +L + E++ + K A + +R + K +
Sbjct: 1720 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1773
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400
R ELA+ L + E ++ Q E AA R + + + A + T+
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1833
Query: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452
K L E ++ ++ AE D+ + Q D+ +QL+K L
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511
+ + VE+ R+ +++ + AL AS E + A G+ + L L ++
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1944
Query: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571
L SKE ++ +LA +ER + L A ++ ++ + E++ ++
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004
Query: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627
EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2061
Query: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687
D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A
Sbjct: 2062 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2120
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747
E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E
Sbjct: 2121 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2173
Query: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807
+ +L + ++L E+ +E A R+R +Q+ +EL + M E
Sbjct: 2174 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2225
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860
AE RA +L +F + E Q+ E+ RL RL
Sbjct: 2226 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279
Query: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913
E R A M + ++A + +L +++ Q Q+ AQ + E E +
Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339
Query: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973
A + E QG++ L A +L +S+ A+ L+ ++ M ++ +
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2393
Query: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032
+ E+ H +TEL A ++T Q L EIQ Q D R E
Sbjct: 2394 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2436
Query: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090
+ +R E LQQ ++ Q E + QE LLQ + S + E + L++R
Sbjct: 2437 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2492
Query: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150
+ A E+ F + ++++ EQ +Q R+ E A +
Sbjct: 2493 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2550
Query: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205
G R E L RR + L AE R+ Q L+ E+ + + E+ + A
Sbjct: 2551 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2607
Query: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242
A P DA + PA A E R+ SA R +E
Sbjct: 2608 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2646
Score = 107 bits (267), Expect = 2e-22
Identities = 362/1768 (20%), Positives = 656/1768 (37%), Gaps = 250/1768 (14%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E R + R L
Sbjct: 511 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 570
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 571 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 622
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 623 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 682
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 683 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 741
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 742 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 775
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 776 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 805
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P E + LE L
Sbjct: 806 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 865
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 866 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 911
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 912 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 971
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 972 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1021
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1022 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1080
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1081 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1134
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1135 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1194
Query: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE
Sbjct: 1195 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1254
Query: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631
A + +++ E + V + LE + S A + + V+ + +Y ++
Sbjct: 1255 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1313
Query: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688
+ + + L M E++ EQ + ++ ++E +E + +A+ Q +A
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1372
Query: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748
E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++
Sbjct: 1373 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1426
Query: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804
A + E + V++ + + G A E L A+ +E + A
Sbjct: 1427 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1485
Query: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864
+ +D +EL A+RE + EL+ Q EE RRL R
Sbjct: 1486 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1544
Query: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922
R +++ R+ E +LQ S+ E AQL EH RE + Q
Sbjct: 1545 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978
E A E+A + +ALR Q + +A Q A + E
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1654
Query: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038
+ K E +A QEL + L + + A+ + + R E +E+ +
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1712
Query: 2039 RHWEWLQQMLEVHQFAQEAVVA-------DAWL----TAQEPLLQSR-----ELGSSVDE 2082
+ + L++ E+ + +EA A +A L E LL S+ E S+ ++
Sbjct: 1713 QQRQLLEE--ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1770
Query: 2083 VEQLIR----RHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKF--FGD 2136
+Q + R + AA +R + + A + + +L K G+
Sbjct: 1771 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE 1830
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTL-------------SAEVRTRVGYVRQ-- 2181
T L +A L+ E E L R A D A++ R+ +R+
Sbjct: 1831 ATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888
Query: 2182 ELKPERLQPRIDRLPEIPGRVEP--AALPAAPEDAAETPA---------------TPAAA 2224
+ + ER + ++ +VE AL A+ E AA A T +
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1948
Query: 2225 EQVRPRPERQESADRAEELPRRRRPER-QESVDQSEEAARRRRPERQESAEHEAAHSLTL 2283
EQ RQ EE RR ER Q+S+ EEAAR+R+ +E +A
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA------ 2002
Query: 2284 GRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGP 2343
+ E+ R RER E+ RQ QE + + KA + Q +E+E L
Sbjct: 2003 -KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV--QQKEQELQQTLQQEQ 2059
Query: 2344 S-LPQPRELPPGRLPNGLELPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAP 2402
S L Q R E E + +R A+ R + R ++ E R+++
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 2403 AQGGSAPAPPPPPTHTVQHEGFLLRKRE 2430
A Q E LR+++
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQ 2147
Score = 102 bits (255), Expect = 4e-21
Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)
Query: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512
EL A +A++KK EA + A + ++G E+ + L E ++ R +
Sbjct: 1110 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1169
Query: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568
+L +W + R+ LEQ + ++E + W+++ Q Q+ +
Sbjct: 1170 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1229
Query: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628
+ L Q+ LLE +I E+VE A ++ + + + Q++ + A+
Sbjct: 1230 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1278
Query: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688
L+ A+ + S S +++QE + + + L T+
Sbjct: 1279 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1320
Query: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744
+S T R + + + L + E R A ++ AL +L A H
Sbjct: 1321 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1369
Query: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804
A+ A+ QR++E RRE +A+ Q + L LR +
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1426
Query: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864
EA+ R R + E+ R + RQ GGA G + AL+ R EAE
Sbjct: 1427 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1476
Query: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924
+ E A R+ ++D R EV E E R +L+++ +
Sbjct: 1477 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1529
Query: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984
++ L ++ VQ +E RS + L S+ E Q + +
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040
+ + E AE RAQ + E RA E A R +W+L EA LQA E Q
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1641
Query: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099
L +A ++ A+ AR AEE LA +A QR + +
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701
Query: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158
+RA+ G + L LEE A L R AA + Q E + A++ A E LLA
Sbjct: 1702 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1755
Query: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218
+ + E ++++ +A R +
Sbjct: 1756 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1783
Query: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278
E+A A L EEA +Q + L + ++Q+ + AE L G E
Sbjct: 1784 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1837
Query: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
A L EK EN+ + + + L+ H+ D I E++ R
Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1885
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388
+A +EL + K +E R+ +Q+ +E L AS K +LG I
Sbjct: 1886 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937
Query: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446
R + E T ++K + EA++ QL AE +++ E ++Q + A
Sbjct: 1938 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500
+ L++++ ++++VEE R + A+ L E A K L E + AV ++ L
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2051
Query: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
+ LQ+ + +L + + A +E A VQ A + + ++Q ++
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2165
Query: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672
QVEQ + + + L ++EL + + + + Q+ ++ + +E
Sbjct: 2166 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2225
Query: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724
+ A++ + RAL+ ++E++ + + RL VA +E R++A E
Sbjct: 2226 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285
Query: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776
+ L + + V E AE E++ EL Q E LQE + A
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2340
Query: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836
++LA Q +E M+ + L AE+ +RAQ A
Sbjct: 2341 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2386
Query: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895
DA+ + Q EE +L R + + + +++ + +HD + L + +L+
Sbjct: 2387 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2442
Query: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955
+L+ +E ++LQ E + + +L + A F S+ LL
Sbjct: 2443 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2489
Query: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
I + ++ +V+ + L Q + ++E L E R
Sbjct: 2490 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2549
Query: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073
Q +L +L ++ + E + L++ L++ + A +A + + +
Sbjct: 2550 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2609
Query: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117
+ L + D ++ A A E F LRR + ++++
Sbjct: 2610 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2645
Score = 89.7 bits (221), Expect = 3e-17
Identities = 323/1513 (21%), Positives = 575/1513 (38%), Gaps = 208/1513 (13%)
Query: 978 QRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPR 1037
+R+E++ A+ L ++ VR Q+R+++ +E R G ++ + + A++
Sbjct: 1214 RRQEQIQAMPLADSQA-----VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1268
Query: 1038 QAALLE-EAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHD 1096
+ L+ +A L PA+ ++ G+E + E+ L + E + +F+ +
Sbjct: 1269 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYS---ELTTLTSQYIKFISE 1325
Query: 1097 LDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L R +E +E EE + L AAL +++ A A ++A
Sbjct: 1326 T------LRRMEEEERLAE---QQRAEERERLAEVEAAL-----EKQRQLAEAHAQAKAQ 1371
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
+ EL + +++ EA +A Q Q L+ LRQ+
Sbjct: 1372 AEREAKELQQRMQ------------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEA-E 1418
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
Q A + +EE ++ R L E + + +QA + QA
Sbjct: 1419 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1478
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQLELQ-HFLRDCHELDGWIHEKMLMARDGTRED 1335
QE RL + Q+ R +Q +L +++ + R+ + E L A + R
Sbjct: 1479 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR- 1537
Query: 1336 NHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEK----PELAASVRKKLGEIRQC 1391
QA + Q + LE +R + +Q K E A + + L E
Sbjct: 1538 ---------LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588
Query: 1392 WAELESTTQAKARQLFEASKADQLVQSFAELDK------KLLHMESQLQDVDPGGDLATV 1445
A+L + +A+Q EA +A + ++ EL++ + L + Q ++V LA
Sbjct: 1589 VAQLREEAERRAQQQAEAERARE--EAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1646
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
++ +K + E R G+ + Q A E A +EL +RQ A G RL Q
Sbjct: 1647 EAEKQK-----EEAEREARRRGKAEEQ-AVRQRELAEQELEKQRQLAEGTAQQRLAAE-Q 1699
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
E RL +++ Q L++ELA +Q A Q Q ++ + K + +
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR-----QELEAELAKVRAEMEVLL 1754
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVR-RGLEQLQSAWAGLREAAERRQQVL--DAAFQ 1622
A R EE R+ + S + EAEA R R L + + L E A+R++Q+ DAA Q
Sbjct: 1755 ASKARAEEE-SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1813
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSED---KGKD----------EQSTLQLLKKHLQLEQG 1669
+ +AE A +GE L + K K+ E Q + Q Q
Sbjct: 1814 RAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1873
Query: 1670 VENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWL 1729
+ EE +AQL + + LE E R++ QV+ +ALK E + A +
Sbjct: 1874 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE--KAAAGKAELE 1931
Query: 1730 YQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 1789
+L R S E + KE + + + +E + +A E A +
Sbjct: 1932 LELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRK 1991
Query: 1790 MVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQL-LAASRELHKFFSDARE--L 1846
E +E ++ + A L+L AQ L A + H F +E L
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2051
Query: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT--- 1903
Q +++++ L +L E A+ R + +Q R+ E A +L+
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV---QAEREAAQSRRQVEEAERLKQSAE 2108
Query: 1904 --VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADA------------LRFHS 1949
A A+A A + ++ + + E A L ADA LR +
Sbjct: 2109 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2168
Query: 1950 QVRDLLSWM------------------DGIASQIGAADKPR-----DVSSVEVLMNYHQG 1986
QV L+ + + ++ A + R ++ SV V M
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2228
Query: 1987 LKTELEARVPELTTCQELGRSLLLNKSA-MADEIQAQLDKLGTRKEEVSEKWDRHWEWLQ 2045
LK +EA L + L + A ++ + +L +E + E L
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288
Query: 2046 Q--------MLEVHQFAQEA--VVADAWLTAQEPLL---QSRELGSSVDEV-EQLIRRHE 2091
Q + E Q QEA + A+A L Q+ L Q+R L +++ +QL +
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 2092 AFRKAAAAWEERFSSLRRLTTIEKIK---AEQSK------------QPPTPLLGRKFFGD 2136
F++ A ER L E++K AE S+ + +G K
Sbjct: 2349 GFQRTLEA--ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR- 2405
Query: 2137 PTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLP 2196
TELA + L + LE + R+ SD + +R + + +E + + + ++ +L
Sbjct: 2406 -TELATQEKVTL-----VQTLE-IQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458
Query: 2197 -EIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEEL-------PRRRR 2248
E V+ L + ++ + + R R QE A + E+L ++ R
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLR 2517
Query: 2249 PERQESVDQSEEAARRRRPERQESA--EHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306
E+Q Q E+ +R +E+ +HEA E+ RR++ ++LE+Q
Sbjct: 2518 EEQQRQQQQMEQERQRLVASMEEARRRQHEA---------EEGVRRKQEELQQLEQQRRQ 2568
Query: 2307 EQEMPIRGDLVKGKATLADIVEQLQEKEAGPGLPAGPSLPQPRELPPGRLPNGLELPERT 2366
++E+ L + L + ++ L+E+ +L E+ ++ LP
Sbjct: 2569 QEEL-----LAEENQRLREQLQLLEEQHRA-------ALAHSEEVTASQVAATKTLPNGR 2616
Query: 2367 PRPDRPRARDRPK 2379
D P A P+
Sbjct: 2617 DALDGPAAEAEPE 2629
Score = 81.3 bits (199), Expect = 1e-14
Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)
Query: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690
E A+R +AE EA+R LQ LEE A + ER L A A A TA
Sbjct: 1502 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1557
Query: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750
S+ A L ++ + + A L+++L+ EE VA
Sbjct: 1558 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1590
Query: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810
Q EEA R +++ + RA + +L+ +A RL + + S +
Sbjct: 1591 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645
Query: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870
+ + E EA R G + A L Q+ A+Q A E+
Sbjct: 1646 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1702
Query: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930
LR E GE+++ LL +++ +Q + Q+
Sbjct: 1703 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1736
Query: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
L + V ++ L+ + +E RS + R +E R E++
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1787
Query: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050
E A +RA E +R Q +L+ +AA Q E + L E+ A + E
Sbjct: 1788 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1830
Query: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110
A RL AE A E A RL+R D +AF + Q A
Sbjct: 1831 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1871
Query: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165
E L + +D+ L R L E+ + QR + I+A AS AA AEL
Sbjct: 1872 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1930
Query: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225
LELG ++ E + QA L RQ + +
Sbjct: 1931 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 1973
Query: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L
Sbjct: 1974 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2033
Query: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343
+ ++ + QQ Q+L L+ + + D +L G + R + +
Sbjct: 2034 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2083
Query: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403
++ + A+ + E E++++ ++ Q + + A+ K E Q A QA
Sbjct: 2084 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Query: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455
RQ A A+Q ++ A+++++L + QL++ D +L Q K ++
Sbjct: 2144 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2203
Query: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504
E SQVEE V + + L +E ++ L+ Q + E ++ +
Sbjct: 2204 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263
Query: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559
+E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ +
Sbjct: 2264 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2323
Query: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619
L +E RL+E E+ +A + E + +R LE AER++Q L+
Sbjct: 2324 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2364
Query: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ + E+ VAE MS + + E+ + K+ ++ + + E
Sbjct: 2365 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2407
Query: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737
L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S
Sbjct: 2408 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2459
Query: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797
E + +++++ + L Q F L EK S + RER
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2494
Query: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857
+ + A+L +L RE + + Q Q+E++R+RL
Sbjct: 2495 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2534
Query: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917
+ + E R + +R + +LQ L Q RQ +E A+ E + + +
Sbjct: 2535 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2591
Query: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976
+ L +E+ ++ A + + DAL + + DG+ ++ A + + S
Sbjct: 2592 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2651
Query: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016
E L QG T V EL +++ R L +S++A
Sbjct: 2652 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2685
Score = 67.0 bits (162), Expect = 2e-10
Identities = 277/1408 (19%), Positives = 521/1408 (37%), Gaps = 194/1408 (13%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + L+ DA L VR A + G +
Sbjct: 368 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 427
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 428 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 486
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 487 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 539
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E + K++ A ++ EG L A L+ L + +
Sbjct: 540 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 595
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 596 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 653
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 654 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 713
Query: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472
E + +L ++ L+ D + + L+ Q + Q+ E+ + L +
Sbjct: 714 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 773
Query: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516
A+ P PA + +Q V G+ +L+ P Q +L+S
Sbjct: 774 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 832
Query: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567
+ + E RL Q + L + + Q LRR++Q
Sbjct: 833 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 890
Query: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626
L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E
Sbjct: 891 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 937
Query: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667
E + + L+ S ++G E+S Q L LQLE
Sbjct: 938 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 997
Query: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
VE + +A+LS + +L + P S +S+++
Sbjct: 998 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1056
Query: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760
L+++ + LE+ + + R E + E V A PEL
Sbjct: 1057 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1116
Query: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817
+ L+ + +E T A R+ L ++ + L + + W++ L E W
Sbjct: 1117 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1175
Query: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875
+L R +L R+L + A L +++ RRR ++ P A Q R
Sbjct: 1176 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1235
Query: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924
+A +++ +V + Q A Q L+ V E +AS ++ +V G
Sbjct: 1236 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1295
Query: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979
+ ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE
Sbjct: 1296 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1354
Query: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033
L H K + E EL Q+ + ++ + A + Q Q + +++
Sbjct: 1355 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093
+ + + + E + ++ + + + + R+ G + E++ L R E
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471
Query: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135
+E LRR L + K +AE +++ L +
Sbjct: 1472 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1531
Query: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195
+ E + A + R + LE R A L ++ R + + + ER L
Sbjct: 1532 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1582
Query: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESAD-------RAEEL 2243
E E A+ E+A A AE+ R ER Q A+ +AEE+
Sbjct: 1583 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1637
Query: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303
+++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++
Sbjct: 1638 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1694
Query: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330
++EQE+ +R + +G+ + E+L
Sbjct: 1695 LAAEQELIRLRAETEQGEQQRQLLEEEL 1722
Score = 60.5 bits (145), Expect = 2e-08
Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 279 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 337
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 338 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 385
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 386 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 420
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 421 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 466
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 467 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 518
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E + RA +E D Q
Sbjct: 519 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 567
Query: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749
+S ++D Y L + R +LE L+ ++ W+ EKE
Sbjct: 568 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 622
Query: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805
E+G D+ +++ +E +S E + +++ + D L+ H A T+
Sbjct: 623 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 679
Query: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
++ L W+ +L+L L + +FFSD RE +GQ+++ + L
Sbjct: 680 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 731
Query: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922
R + T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 732 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 782
Query: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966
G LL+ C+ ++ V+ A H +V + S
Sbjct: 783 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 842
Query: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
P + +V L HQ L T +L + L Q L R + L +S
Sbjct: 843 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 895
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080
L T K E + LE+H A DA ++ L+ RE GS
Sbjct: 896 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 948
Query: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131
+QL++ E + + + S L+ + T+ +++ K+P R
Sbjct: 949 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1008
Query: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181
K + L A L L P A+ TL +E+ +G + Q
Sbjct: 1009 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1067
Query: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233
+LK L R + E R L A P E AT A+ +++R + E
Sbjct: 1068 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1127
Query: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293
Q+ A R E + + + E +R E + L R++ + +
Sbjct: 1128 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1181
Query: 2294 ERRERRLER 2302
+ R+R LE+
Sbjct: 1182 DVRQRELEQ 1190
Score = 59.7 bits (143), Expect = 4e-08
Identities = 302/1357 (22%), Positives = 480/1357 (35%), Gaps = 245/1357 (18%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
E+E+A + A A+ + +L+ F K A E L E V+Q E A
Sbjct: 1542 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 465 EAA-----------------MKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVA 507
+ A +K +EA+ + A E V LAQA A + + R A
Sbjct: 1602 QQAEAERAREEAERELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEKQKEEAEREA 1659
Query: 508 AQR----DSVLRQWALLTGLVGARRTRLEQNLALQKVF--QEMVYMVDWME--EMQAQLL 559
+R + +RQ L + +R +L + A Q++ QE++ + E E Q QLL
Sbjct: 1660 RRRGKAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1718
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
E + EA QK LE ++A +E L A+ R + + R+
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE---ESRSTSEKSKQRL 1775
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLL--EAAGGGGAAG 677
G EL E+AAR RA E ++ L +E +A + ER+L + A G A
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAERVLAEKLAAIGEATR 1833
Query: 678 AAGAAGTA----------------------------GGAHDLSSTARLLAQHKILQGELG 709
A A H RL K EL
Sbjct: 1834 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE 1893
Query: 710 GRRALLQQ-------------ALRCGEELVAAG--------GAVGPGA-DTVHLVGLAER 747
++ L++ AL+ E AAG G + A DT+ AE
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953
Query: 748 AASARRRWQRLEEAAARRE--RRLQEARALHQFGA--------DLDGLLDWLRDAYRLAA 797
A AR+R EE RRE R+Q++ A + A +++ L + +A RL
Sbjct: 1954 EA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2012
Query: 798 AGDFGHDEASSRRLARQ--HRALTGEVEAH-------------------------RGPVS 830
+ + A +LA++ + L E +AH RG
Sbjct: 2013 RAE--QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2070
Query: 831 GLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEV 890
RR A A R VE + + E A R + A R E
Sbjct: 2071 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2130
Query: 891 HACELWIGEKEQWLLSMRVPDSLDDVEVVQHRF---------ESLDQEMNSLMGRVLDVN 941
A + EQ L + D E+ +H+ ++QE+ +L ++ + +
Sbjct: 2131 EAARR--AQAEQAALRQK---QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD 2185
Query: 942 HTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRA 1001
H L E L E QR + + V + E+++++A
Sbjct: 2186 HQKNLLDE--------------ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 1002 QVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQ 1061
++ + RA+ + + LQ + + EEAA L+ +AARL Q
Sbjct: 2232 RIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQEAARLRQ 2281
Query: 1062 GAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLHDLDAFLD 1102
AEE A+ ALA A Q A A LQ R D +
Sbjct: 2282 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341
Query: 1103 WLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARIVAASEAL 1156
L A+E G E LE EA+ L R A + + EED R +E
Sbjct: 2342 QL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAE-- 2397
Query: 1157 LAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLR 1216
E+G E L EL + + L + +Q LR+A+ L
Sbjct: 2398 ------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLREAIAELE 2442
Query: 1217 NQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA 1276
++ L ++S E Q L Q +Q + + + L Q + EQ
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQRERFIEQE 2498
Query: 1277 QEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR- 1333
+ + +L + + QLR +Q Q+ + E Q + E HE A +G R
Sbjct: 2499 KAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRR 2554
Query: 1334 --EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQ 1390
E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS +
Sbjct: 2555 KQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPN 2614
Query: 1391 CWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG----GDLATV 1445
L+ +A+ F+ + Q E +L E +LQ + G +LA
Sbjct: 2615 GRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTTVDELARR 2671
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGERLVRLLE 1502
LQ S + E + AAL L P + ++ E Q A G LL+
Sbjct: 2672 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG----FLLD 2727
Query: 1503 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
P++ RR + + + V +L +L + + G + Q +GL
Sbjct: 2728 PVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---AMQKGL-- 2782
Query: 1563 EIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595
++ HG RL E G + S R P A RRG
Sbjct: 2783 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2819
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 227 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 283
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 284 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 343
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 344 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 402
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 403 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 462
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 463 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 518
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 519 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 571
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 572 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 622
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
sapiens]
Length = 1369
Score = 299 bits (766), Expect = 2e-80
Identities = 240/804 (29%), Positives = 376/804 (46%), Gaps = 79/804 (9%)
Query: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116
DER+ VQKKT TKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GRMR
Sbjct: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
Query: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176
H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ +
Sbjct: 230 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
Query: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236
E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ +
Sbjct: 289 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
Query: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296
NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G R
Sbjct: 348 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
Query: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356
E+ + Y EL LL W+ ++F +S ++ F +
Sbjct: 407 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
Query: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416
+E P K +K + + S++ ++A +L VP G D++K WG+L A ERE
Sbjct: 460 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 516
Query: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
LR+E R E L+ + + + + E L++ L+ D L A ++ +E
Sbjct: 517 LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
Query: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528
D+ + ++ + Q L + Y + R+ + ++ ++ L L V A
Sbjct: 574 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 633
Query: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578
T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L H
Sbjct: 634 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 692
Query: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635
L I ++E + + Q+ CL L Q A+
Sbjct: 693 GLHQSIEEFQAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 739
Query: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
+A L + SL + + + W +KE G + + T
Sbjct: 740 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 785
Query: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754
A+ + L EL + +++ G+ L+ P ++ A+ + +
Sbjct: 786 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 836
Query: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811
W + + E L+E A QF +D+ +G L L++A R + D L
Sbjct: 837 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDL 896
Query: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835
+ + ++ ++G +SGL ++
Sbjct: 897 LQDAQDEKEQLNEYKGHLSGLAKR 920
Score = 60.5 bits (145), Expect = 2e-08
Identities = 208/1021 (20%), Positives = 369/1021 (36%), Gaps = 169/1021 (16%)
Query: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400
+W+RH E + E+IE Q ++ K EL A K + + LE Q
Sbjct: 426 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 484
Query: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460
A ++ + + + +L +L E QL+ S+ ++L+ ++ V
Sbjct: 485 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 532
Query: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ E G + E+L + LQ RLL A K + Q
Sbjct: 533 KLQMEAGLCE------------------------EQLHQADALLQSDIRLLAAGK-VPQR 567
Query: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578
A +++ +L + L N +Q ++ +H + Q RR + H ER
Sbjct: 568 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 613
Query: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637
L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+
Sbjct: 614 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 665
Query: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697
E + + + G D S L H L Q +E ++ I RA + G
Sbjct: 666 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIE------RARSDEGQLSPAT 719
Query: 1698 ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 1757
+ + RL + +L + L L+ ++ W+ EKE E+G
Sbjct: 720 RGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE----EEEVGF 775
Query: 1758 DFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLN 1813
D+ +++ +E +S E + +++ + D L+ H A T+ ++ L
Sbjct: 776 DWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTVESFQAALQ 834
Query: 1814 EAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873
W+ +L+L L + +FFSD RE +GQ+++ + L R ++
Sbjct: 835 TQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL--------RRKNSCDR 886
Query: 1874 QRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ----------- 1922
T+ E LQ + QL E Y G H +A R + V+Q
Sbjct: 887 SATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKPRHPAHPMR 937
Query: 1923 GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIGAADKPRD- 1973
G LL+ C+ ++ V+ A H +V + S P
Sbjct: 938 GRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 997
Query: 1974 -VSSVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTR 2029
+V L HQ L T +L + L Q L R + L +S L T
Sbjct: 998 VQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------WSLATFRTL 1050
Query: 2030 KEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSVDEVEQLIR 2088
K E + LE+H A DA ++ L+ RE GS +QL++
Sbjct: 1051 KPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQ 1103
Query: 2089 RHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR-----KFF 2134
E + + + S L+ + T+ +++ K+P R K
Sbjct: 1104 SLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQ 1163
Query: 2135 GDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----------ELK 2184
+ L A L L P A+ TL +E+ +G + Q +LK
Sbjct: 1164 AEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1222
Query: 2185 PERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPERQESADRAE 2241
L R + E R L A P E AT A+ +++R + E Q+ A
Sbjct: 1223 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDA- 1281
Query: 2242 ELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLE 2301
R E + + + E +R E + L R++ + + + R+R LE
Sbjct: 1282 -----LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1336
Query: 2302 R 2302
+
Sbjct: 1337 Q 1337
Score = 48.5 bits (114), Expect = 8e-05
Identities = 149/797 (18%), Positives = 295/797 (37%), Gaps = 141/797 (17%)
Query: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841
L LL W+ + ++G D S HR L +E + + R L
Sbjct: 658 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSP 717
Query: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901
A+ A + + + +A++ + R LR +++ +W+ EKE
Sbjct: 718 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 769
Query: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961
+ + D ++ + + +L +E+ ++ ++ + L+ HP+ V S
Sbjct: 770 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 829
Query: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018
Q L ++W+ +++L +E +E +A + V E +++E R S R+
Sbjct: 830 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSA- 888
Query: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078
++ LE LQ + + L E L+ LA A+
Sbjct: 889 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 922
Query: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138
A + ++ + A G LP LLA + E
Sbjct: 923 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 952
Query: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184
V + D ++V ++ +L++ G+E P + E + LE L
Sbjct: 953 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQAL 1012
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244
+ LW + +Q RD++ ++R+ +A P ++ R
Sbjct: 1013 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 1058
Query: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297
L ++EL Q Q A G + + E+ + + + LE+ + + R Q+
Sbjct: 1059 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 1118
Query: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355
+ +L D +L+L+ R H L ++ + ++ RE +R Q AE+
Sbjct: 1119 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1168
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
+ + ++ E ++++ PE + + E+ +LE A L + +
Sbjct: 1169 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1227
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
++ ++ L E QL++ V + L +L++ ++ +++ + Q A
Sbjct: 1228 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1281
Query: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523
L E + VGER Q GER V + + L ER + +LA +EL Q+
Sbjct: 1282 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1341
Query: 1524 L-------DDELAWVQE 1533
L D AW+Q+
Sbjct: 1342 LRYYRESADPLGAWLQD 1358
Score = 44.7 bits (104), Expect = 0.001
Identities = 87/389 (22%), Positives = 148/389 (38%), Gaps = 53/389 (13%)
Query: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333
++ QEAVTRL ++Q Q + L Q RD + W +
Sbjct: 996 QEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--E 1053
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI----R 1389
E LH L +QAF+ R+ Q PE ++ G +
Sbjct: 1054 EQRQALHSLELHYQAFL--------------RDSQDAGGFGPEDRLMAEREYGSCSHHYQ 1099
Query: 1390 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 1449
Q LE Q ++R S+ + + + +H D +P + A ++
Sbjct: 1100 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRI 1156
Query: 1450 KKLQSMESQVEEWYREVGELQAQTA---ALPL-EPASKELVGERQNAVGE-RLVR----- 1499
+ Q +++VE + V L A+ ALP PA+ L E + +G+ VR
Sbjct: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216
Query: 1500 LLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQG 1559
LE L+ ++ ++ +V +++L Q +P + L+A + +KK
Sbjct: 1217 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA-VPATLPE-----LEATKASLKK--- 1267
Query: 1560 LRREIQAHGPRLE----------EVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREA 1609
LR + +A P + EV ER R E E R + QL W +
Sbjct: 1268 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1327
Query: 1610 AERRQQVLDAAFQVEQYYFDVAE-VEAWL 1637
+ RQ+ L+ + +YY + A+ + AWL
Sbjct: 1328 TDVRQRELEQLGRQLRYYRESADPLGAWL 1356
Score = 43.9 bits (102), Expect = 0.002
Identities = 198/958 (20%), Positives = 363/958 (37%), Gaps = 165/958 (17%)
Query: 852 LQVRVVEAE-QLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVP 910
L V ++E E QL +E + L+R + + ++H + + + L + +VP
Sbjct: 506 LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVP 565
Query: 911 DSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWN 970
+VE ++++ + + + VQ L +G HP +++ L+ R
Sbjct: 566 QRAGEVE----------RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHER-- 613
Query: 971 RIVELVEQRKE-EMSAVLLVENHVLEVAEVRAQVREKRRAVESAP--------------- 1014
LV R E + V +VA+V Q ++R +E +
Sbjct: 614 ----LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQ 669
Query: 1015 -RAGGALQWR--LSGLEAAL-------QALEPRQAALLEEAALLAERFPAQAARLHQGAE 1064
R GA +W L +EA L Q++E QA + + + PA
Sbjct: 670 HRVDGA-EWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLG 728
Query: 1065 ELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEE 1124
L ++ L ++++A + + L F+ L WL +E G + N+
Sbjct: 729 RLDLQYAKLLNSSKA---RLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--N 783
Query: 1125 ADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKL 1184
A ++AL E++ +E+ + A + LL D ++ + L+ W +
Sbjct: 784 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARP---TVESFQAALQTQWSWM 840
Query: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHR-- 1242
L L L + Y F D+R+A G ++ ++EAL++
Sbjct: 841 LQLCCCIEAHLKENAAYFQFFSDVREA----------------EGQLQKLQEALRRKNSC 884
Query: 1243 DFLTTMELSQQKMQVAVQAAEGLLR-QGNIYG-EQAQEAVTRLLEKNQENQLRAQQWMQK 1300
D T+ + +Q A E L +G++ G + +AV +L ++ + +R + +
Sbjct: 885 DRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLA 944
Query: 1301 LHD--QLELQHFLRDCHELDGWI---HEKMLMARDG--------------TREDNHKLHK 1341
+ D Q+E+ D +L G H K+L + +E + +
Sbjct: 945 VCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTR 1004
Query: 1342 RWLRHQAFMA-------ELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAE 1394
+HQA + ++ W + + R+ Q + LA K E RQ
Sbjct: 1005 LEAQHQALVTLWHQLHVDMKSLLAW-QSLRRDVQLIRSWS--LATFRTLKPEEQRQALHS 1061
Query: 1395 LESTTQAKARQLFEASK--ADQLVQSFAELDKKLLHMESQLQDVDPGG-DLATVNSQLKK 1451
LE QA R +A + + + E H + LQ ++ G + + + +
Sbjct: 1062 LELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISE 1121
Query: 1452 LQSMESQVEEWYREVGELQAQTAALPLEPASK--ELVGERQNAVGE--RLVRLLEPLQER 1507
L+ + Q+E E + L EPA + + + E+Q A E L + + L
Sbjct: 1122 LKDIRLQLEAC--ETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1179
Query: 1508 RRLLLASKELHQVAHDLDDELAWV-----QERLPLAMQTERGNGLQAVQQHIKKNQGLRR 1562
+LA E A L EL Q R A+ E+ L+ + I+ QG
Sbjct: 1180 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK---LKTISLVIRGTQGAEE 1236
Query: 1563 EIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQ 1622
++AH EE L+ A A+ + PE EA + L++L R AE +Q DA
Sbjct: 1237 VLRAH----EEQLKEAQAVPATL-PELEATKASLKKL-------RAQAEAQQPTFDA--- 1281
Query: 1623 VEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSR 1682
+ E +G E +L ++H + + VE + E +AQL
Sbjct: 1282 ---------------------LRDELRGAQEVGE-RLQQRHGERDVEVERWRERVAQLLE 1319
Query: 1683 QCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740
+ +A+L Q RQ ++++L ++L R A WL R+ +++
Sbjct: 1320 RWQAVL-------AQTDVRQRELEQLG---RQLRYYRESADPLGAWLQDARRRQEQIQ 1367
Score = 43.1 bits (100), Expect = 0.003
Identities = 204/1044 (19%), Positives = 375/1044 (35%), Gaps = 186/1044 (17%)
Query: 1089 RLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKE-EVDQREEDYA 1147
R Q + + L W+ A E P+S EE + L ++ KE E+ +E D
Sbjct: 413 RWQEYRELVLLLLQWM--RHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470
Query: 1148 R---IVAASEALLAADGAELGPGL-ALDEWLPHLELGWHKL-LGLWEARREALVQAHIYQ 1202
R I + E + A ++ PG LD +E W KL + + E ++ + +
Sbjct: 471 RSKGIYQSLEGAVQAGQLKVPPGYHPLD-----VEKEWGKLHVAILEREKQLRSEFERLE 525
Query: 1203 LFLR--------------DLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTM 1248
R L QA +L++ L+ ++P VE L + + +
Sbjct: 526 CLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLL 585
Query: 1249 ELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLR------------AQQ 1296
Q ++ +G QG + RL+ E LR AQ
Sbjct: 586 FNDVQTLK------DGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQV 639
Query: 1297 WMQKLHDQLELQHF-LRDCHELDGWIHEKMLMARDGTR--EDNHKLHKRWLRHQAFMAEL 1353
+Q + + EL+ LR +L W+ E DG D + + H+ +
Sbjct: 640 TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRV-DGAEWGVDLPSVEAQLGSHRGLHQSI 698
Query: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKAD 1413
+E+ KIER Q P + R LG + +A+L ++++A+ R L
Sbjct: 699 ---EEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL------- 748
Query: 1414 QLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQT 1473
+ + SF K L ++ ++ + G D + N+ +M ++ E + + EL+ +
Sbjct: 749 ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNT------NMTAKKESYSALMRELELK- 801
Query: 1474 AALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQE 1533
++ + E QNA G+RL+R P + E
Sbjct: 802 ---------EKKIKELQNA-GDRLLREDHPARP------------------------TVE 827
Query: 1534 RLPLAMQTERGNGLQ---AVQQHIKKNQGLR------REIQAHGPRLEEVL------ERA 1578
A+QT+ LQ ++ H+K+N RE + +L+E L +R+
Sbjct: 828 SFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRS 887
Query: 1579 GALASLRS--PEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAW 1636
+ L +A+ + L + + +GL + A+ A Q++ +
Sbjct: 888 ATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAK-------AVVQLKPRH----PAHPM 936
Query: 1637 LGEQELLMMSEDKGKD----EQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGH 1692
G LL + + K + + QL+ V + S A + C +
Sbjct: 937 RGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLV----P 992
Query: 1693 PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGS 1752
P ++++ ++++ + AL L + V ++ L R V + W
Sbjct: 993 PPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP 1052
Query: 1753 PELGQDFEHVSVLQEKFSEFASETGMAGRE-RLAAVNQMVDELIECGHTAAATMAEWKDG 1811
E Q + + + F + + G G E RL A E C H + + G
Sbjct: 1053 EEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER----EYGSCSHHYQQLLQSLEQG 1108
Query: 1812 LNE---AWAELLELMGTRAQLLAA----------------SRELHKFFSDARELQGQIEE 1852
E + EL R QL A +RE + ++ ++ Q ++E
Sbjct: 1109 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1168
Query: 1853 KRRRLPRLTTP-------PEPRPSA----SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQL 1901
+ + RL+ PEP P+A S ++ TL E L + +L+ + +
Sbjct: 1169 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1228
Query: 1902 RTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGI 1961
R E E + + E+++ KE + ++ A + +Q D +
Sbjct: 1229 RGTQGAE--EVLRAHEEQL----KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1282
Query: 1962 ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021
++ A + E L H E+E + E +++L A D Q
Sbjct: 1283 RDELRGAQEVG-----ERLQQRHGERDVEVERWRERVAQLLERWQAVL----AQTDVRQR 1333
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQ 2045
+L++LG + E D WLQ
Sbjct: 1334 ELEQLGRQLRYYRESADPLGAWLQ 1357
Score = 40.0 bits (92), Expect = 0.030
Identities = 146/723 (20%), Positives = 271/723 (37%), Gaps = 62/723 (8%)
Query: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121
++L +E+ L + + AG + LH DA L +R A + G +
Sbjct: 515 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERD 574
Query: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176
L++AD+++ LK+ Q E+ Y R+ E L+A E L P
Sbjct: 575 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 633
Query: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236
++ L + RR L + LR L+ L + + + GAE + SVE
Sbjct: 634 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 686
Query: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296
L HR ++E Q K++ A ++ EG L A L+ L + +
Sbjct: 687 QLGSHRGLHQSIEEFQAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 742
Query: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355
+L L F+ + W++EK D N + + + A M EL
Sbjct: 743 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
Query: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415
++ +++++ G +L++E +V ++ W+ + L E + Q
Sbjct: 801 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
Query: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475
E + +L ++ L+ + ATV LQ + + E+ G L
Sbjct: 861 FSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSG---- 916
Query: 1476 LPLEPASKELVGERQNAVGERLVR-LLEPLQERRRLLLAS--KELHQVAHDLDDELAWVQ 1532
+ +R AV + R P++ R LL K++ H DE V
Sbjct: 917 ----------LAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK-GDECQLVG 965
Query: 1533 ERLPLAMQTERGNGLQAVQQHI-----KKNQGLRREIQAHGPRLEEVLERAGAL-----A 1582
P + +G +A + NQ E+Q RLE + L
Sbjct: 966 PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQ----EVQEAVTRLEAQHQALVTLWHQLHV 1021
Query: 1583 SLRSPEA-EAVRRGLEQLQS-AWAGLRE-AAERRQQVLDAAFQVEQYYFDVAEVEAWLGE 1639
++S A +++RR ++ ++S + A R E ++Q L + Q + ++ G
Sbjct: 1022 DMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGP 1081
Query: 1640 QELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQIS 1699
++ LM + G QLL+ LEQG + +S L++ ++ +
Sbjct: 1082 EDRLMAEREYGSCSHHYQQLLQ---SLEQGAQEESRCQRCISELKDIRLQLEACETRTVH 1138
Query: 1700 RRQSQVDR--LYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQ 1757
R + +D+ + + E+++ E + ++R +E E +A E +P L
Sbjct: 1139 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1198
Query: 1758 DFE 1760
+ E
Sbjct: 1199 ELE 1201
Score = 38.9 bits (89), Expect = 0.066
Identities = 56/236 (23%), Positives = 89/236 (37%), Gaps = 24/236 (10%)
Query: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619
+REC Q + E + ++ + V L+A A + L P P +
Sbjct: 1149 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1197
Query: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679
+ + L +L++ + LE +++ +++ + AE R E L+ A A
Sbjct: 1198 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1257
Query: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739
A A S +L AQ + Q R L+ A GE L G V
Sbjct: 1258 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1305
Query: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYR 794
+ ER A RWQ + R+R L++ R L + D L WL+DA R
Sbjct: 1306 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1361
Score = 35.8 bits (81), Expect = 0.56
Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)
Query: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745
+++ PD + I + V LY A+ + + + A E Q + V L W+
Sbjct: 374 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 430
Query: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802
FE + +L KF E A + R + Q ++ ++ G
Sbjct: 431 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 490
Query: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858
D + + W +L + R + L + E L + + + G EE+ +
Sbjct: 491 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQAD 549
Query: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906
RL + A ++R L + ++LL + V+ L++G R VY
Sbjct: 550 ALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 609
Query: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958
H +A R + L+ + + A + A++ + S LR+ ++DLL+W+
Sbjct: 610 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 665
Query: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018
+ ++ A+ D+ SVE + H+GL +E E E RS ++ ++
Sbjct: 666 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFQAKIERARS---DEGQLSPA 718
Query: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068
+ A D LG + ++ + L+ + +H F A WL +E
Sbjct: 719 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 769
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 295 bits (755), Expect = 4e-79
Identities = 191/468 (40%), Positives = 270/468 (57%), Gaps = 30/468 (6%)
Query: 55 LADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGR 114
+ADER+ VQKKTFTKW+N HL +V H+ DLY DLRDG L LLEVLSG+ LPR +GR
Sbjct: 58 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 116
Query: 115 MRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETE 174
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI I + E
Sbjct: 117 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 176
Query: 175 DNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTK 234
E SAK+ LLLW Q T GY + +NFTT WRDG FNA+IH++RPDL+D + +
Sbjct: 177 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 234
Query: 235 SNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEG 294
+ NL+ AF AE+ +G+ RLLDPEDV++ +PDEKS+ITYV S Y F K+ G
Sbjct: 235 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 290
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
+ IG +V K IE Y+ + L+ WI V +S + F N+ ++ + +
Sbjct: 291 EGIGANDVEV----KWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 345
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
E P K EK ++ L ++ + +L +G DI+K WG+L A ERE
Sbjct: 346 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 402
Query: 415 AALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAI 474
ALR E+ R E L+ +A R R+S + E++ +++ + + +E+ ++
Sbjct: 403 KALRPEVERLEMLQQIANR-----VQRDSVICEDKLILAGNALQSDSKRLESGVQFQN-- 455
Query: 475 EADIAAY----EERVQGVAELAQALAAEGYYD----IRRVAAQRDSVL 514
EA+IA Y E ++ Q L YY ++RVA RD ++
Sbjct: 456 EAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIM 503
Score = 142 bits (358), Expect = 4e-33
Identities = 396/1970 (20%), Positives = 766/1970 (38%), Gaps = 190/1970 (9%)
Query: 242 QRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVL 301
Q++ + + + LA+ L +D+ +EA D K ++ + L+ + L
Sbjct: 3051 QKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFL 3109
Query: 302 DQVLE-VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKP 360
+ L+ +G E+ ++ + + + A +L ++ ++AF L+K
Sbjct: 3110 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF-----LKK- 3163
Query: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
LE L+ S + + C L + I + +LE + L
Sbjct: 3164 --------LEALMASNDNANKTCKMMLATEETSPDLVGIKR---DLEALSKQCNKLLDRA 3212
Query: 421 LIRQEKLELLAQRFDHKVAMRESWL----NENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
R+E++E +R + + + + + SQ G E + + + +
Sbjct: 3213 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3272
Query: 477 D-IAAYEERVQGVAELAQAL--AAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQ 533
+ I + + Q V L Q L +A + + D V +W L V R +L++
Sbjct: 3273 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3332
Query: 534 NLALQKVFQEMVY-MVDWM---EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE 589
L FQ+ + ++ WM EE+ A +V+A +Q+ LL+ + +
Sbjct: 3333 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ--IQEQKLLQRLLDDRKS 3390
Query: 590 RVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649
VE + + + +P D I +++ + L +A R +LE +
Sbjct: 3391 TVEVIKREGEKIATTA--EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3448
Query: 650 LQE-LEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGEL 708
E LE W E+ L G S +AQHK L+ ++
Sbjct: 3449 FHETLEPLNEWLTTIEKRLVNCEPIGTQA--------------SKLEEQIAQHKALEDDI 3494
Query: 709 GGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQ-RLEEAAARRER 767
L QA+ G+ L + + + W ++E + R
Sbjct: 3495 INHNKHLHQAVSIGQSLKVLSSREDK--------DMVQSKLDFSQVWYIEIQEKSHSRSE 3546
Query: 768 RLQEARALHQ-FGADLDGLLDWLRDAY-RLAAAGDFGHDEASSRRLARQHRALTGEVEAH 825
LQ+A + FG D L++WL + + +L+ + + + R L ++
Sbjct: 3547 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3606
Query: 826 RGPV-SGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVY 884
+ V L L L +G L++ ++ ++A + ++T+++ + L AL +
Sbjct: 3607 KQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR--YKDITKLSTDVAKTLEQALQLA 3664
Query: 885 RMFGEVHACEL--WIGEKEQWLLSMRVPD-SLDDVEVVQHRFESLDQEM---NSLMGRVL 938
R H EL W+ + E LLS ++ Q R + L +E +L+ +
Sbjct: 3665 RRLHSTHE-ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3723
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE 998
+V+ + ELV E +D N R+ + + + Q+ EE+ A +L + A+
Sbjct: 3724 EVSSALLELVPWRAREGLEKMVAED--NERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3781
Query: 999 VR-AQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAA 1057
+ + E + + S G ++ A LQ + +L ++ + +
Sbjct: 3782 AELSWITETEKKLMSL----GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3837
Query: 1058 RLHQGAEE--------LGAEWGALASAAQACGEAVAAAGRLQ----RFLHDLDAFLDWLV 1105
+ +EE L + Q E R Q +F + WL
Sbjct: 3838 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3897
Query: 1106 RAQEAAGGSEGPLPN-SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAEL 1164
Q S+ P P E H L+E + + + ++ LL
Sbjct: 3898 ETQSII--SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP--- 3952
Query: 1165 GPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRD-LRQALVVL-RNQEMAL 1222
G G ++ E + + ++ + R AL +A D + Q L L R E
Sbjct: 3953 GEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4012
Query: 1223 SGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQG-----NIYGEQAQ 1277
+ VE ++E + ++++ ME Q + Q E ++ + +I + Q
Sbjct: 4013 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4072
Query: 1278 EAVTRLLEKNQENQLRAQQWMQKLHDQLEL-QHFLRDCHELDGWIHEKMLMARDGTREDN 1336
+ + +++ + ++ KL D +EL + F D L I + RD ++
Sbjct: 4073 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD---LED 4129
Query: 1337 HKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS--------VRKKLGEI 1388
+ ++ Q AE +E ++ ++ E ++ EL A+ V+K + E+
Sbjct: 4130 PGIDPSVVKQQQEAAETI--REEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4187
Query: 1389 RQCWAELESTTQAKARQLFEASKA-----DQLVQSFAELDKKLLHMESQLQDVDP-GGDL 1442
W L + + +L EA +A D L F +D +L + P G DL
Sbjct: 4188 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD----IAGGKLASMSPIGTDL 4243
Query: 1443 ATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-- 1500
TV Q+++L+ +S+ + E+ L Q A L L+ ++E ++ V + L+ L
Sbjct: 4244 ETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEE---SDKHTVQDPLMELKL 4299
Query: 1501 -LEPLQER-----RRLLLASKELHQVAHDLDDELAWV--QERLPLAMQTERGNGLQAVQQ 1552
+ L+ER +L A L Q H LD+ LAW+ E L L+ Q G +A++
Sbjct: 4300 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-LSEQKPVGGDPKAIEI 4358
Query: 1553 HIKKNQGLRREIQAHGPRLEEVLERAG--ALASLRSPEAEAVRRGLEQLQSAWAGLREAA 1610
+ K+ L+ ++ AH +E V +AG + S EA ++ LE L W + E
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAV-NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4417
Query: 1611 ERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQEL-LMMSEDKGKDEQSTLQLLKKHLQLEQ 1668
E+R+Q LD A Q + ++ ++ +++ WL + E L+ S+ G ++ + L H+++
Sbjct: 4418 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4477
Query: 1669 GVENYEESIAQLSRQCRALLEMGHPDSE-QISRRQSQVDRLYVALKELGEERRVALEQQY 1727
E EE+ L ++ + +L +E I + + + + +++ ER+ LE+
Sbjct: 4478 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4537
Query: 1728 WL-YQLSRQVSELEHWIAEKEV---VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 1783
L + + + +W+ + E VA P L D + + K FA+E + RE+
Sbjct: 4538 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVN-SHREQ 4594
Query: 1784 LAAVNQMVDELIECGHTAAATMAE-WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD 1842
+ +++ L + + + W ++++ + R + L +R+ K F +
Sbjct: 4595 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4654
Query: 1843 A-RELQGQIEEKRRRLP---RLTTPPEPRPSA----SSMQRTLRAFEHDLQLLVSQVRQL 1894
A +L +EE + L + P+ + Q++L A R L
Sbjct: 4655 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714
Query: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD- 1953
+E +T A ++ + + E+ W + C + + +AL F Q D
Sbjct: 4715 KE-----KTSLADDNLK-LDDMLSELRDKWDTI---CGKSVERQNKLEEALLFSGQFTDA 4765
Query: 1954 ---LLSWMDGIASQIGAADKP--RDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSL 2008
L+ W+ + Q+ A D+P D+ V L++ H+ + EL R + + R L
Sbjct: 4766 LQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4824
Query: 2009 LLNKSAMADEIQAQLDKLGTRKEEVS----EKWDRHWEWLQQMLEVHQFAQEAVVADAWL 2064
+ + ++ Q+ +L TR E V K R L+Q E H + WL
Sbjct: 4825 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL---EWL 4881
Query: 2065 TAQEPLLQSR-ELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTI 2113
E L+ L D + LI +H+ F K EE+ + L + TT+
Sbjct: 4882 AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 4928
Score = 118 bits (295), Expect = 9e-26
Identities = 352/1865 (18%), Positives = 745/1865 (39%), Gaps = 139/1865 (7%)
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
K++ + Q+ E R+++ LL+W+ T L++NQK ++ V +
Sbjct: 3321 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK-------- 3372
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
+ QE+ L+ LL +S + R D K +L + E
Sbjct: 3373 ------AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3426
Query: 415 AALRAELIRQEKLE---LLAQRFDHKVAMRESWLNE-NQRLVSQDNFGYELPAVEAAMKK 470
A L R +LE ++AQ+F + WL +RLV+ + G + +E + +
Sbjct: 3427 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQ 3486
Query: 471 HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARRT 529
H+A+E DI + + + + Q+L + + + + + W + + +R
Sbjct: 3487 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3546
Query: 530 RLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH-GLLEGDIAAQ 587
L+Q L K+F ++ V +++W+ E+ +L + E Q +L+ DI +
Sbjct: 3547 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3606
Query: 588 SERVEA--LNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAE-LEASR 644
+ V+ LN L Q G + Q + + + +L A+ + L+ +R
Sbjct: 3607 KQNVDQALLNGLEL-LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3665
Query: 645 SLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKIL 704
L + +EL +W E L + G + +S A++ + K L
Sbjct: 3666 RLHSTHEELC---TWLDKVEVELLSYETQVLKG------------EEASQAQM--RPKEL 3708
Query: 705 QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAAR 764
+ E +ALL + L A+ GL + A R++ + + +
Sbjct: 3709 KKEAKNNKALL-------DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3761
Query: 765 RERRLQEA-RALHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEV 822
+ + A QF D L W+ + + L + GD ++ + + + T E+
Sbjct: 3762 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3821
Query: 823 EAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALA 882
H+ + L + + A +++ ++ + + + + ++ + R L A +
Sbjct: 3822 LRHKDIIDDLVKSGHKIMTACSEEEKQ-SMKKKLDKVLKNYDTICQINSERYLQLERAQS 3880
Query: 883 VYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGR----VL 938
+ F E + ELW E + ++P + E ++ + E +++ L+ +
Sbjct: 3881 LVNQFWETYE-ELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHID 3938
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRK----EEMSAVLLVENHVL 994
+N T +L+E ++ ++ +++I E V++R E +S + +
Sbjct: 3939 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3998
Query: 995 EVAEVRAQVREKRRAVESAPRAGGALQWRLS---GLEAALQALEPRQAALLEEAALLAER 1051
++ E ++ E+ R S ++ ++S + ++ L+P L + + R
Sbjct: 3999 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4058
Query: 1052 FPA-----QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL-QRFLHDLDAFLDWLV 1105
A + +++ W + + + + L ++F D + + +
Sbjct: 4059 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4118
Query: 1106 RAQEAAGGSEGPLPNSLEEADALLARHAA--LKEEVDQREEDYARIVAASEALLAADGAE 1163
Q+ E P ++ + + AA ++EE+D +E+ ++ L+AA G
Sbjct: 4119 DTQDFIRDLEDP---GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4175
Query: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQAL---VVLRNQEM 1220
P + + + L W L W+ R + L +A + +D QA+ V + ++
Sbjct: 4176 DKP--IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4233
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLR----QGNIYGEQA 1276
A S + + +E+V++ +++ + F + Q +M+ AE LL+ + + + Q
Sbjct: 4234 A-SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4292
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQL-ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+L+ + E ++ +Q KL L L F EL W+ E +L +
Sbjct: 4293 PLMELKLIWDSLEERIINRQ--HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4350
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCW 1392
D + +H ++ ++ +E + + G L++ E A++++ KL + Q W
Sbjct: 4351 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4410
Query: 1393 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VN 1446
+ T+ + +QL A + A +L + L E L P G L +N
Sbjct: 4411 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN 4470
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQ 1505
++ + E++ EE Y+ + +Q L P S E + + N + E+ + L
Sbjct: 4471 VHMEVCAAFEAK-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLN 4527
Query: 1506 ERRRLLLASKELHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 1563
ER+ L + L H+ L D + W+ Q L + + L V I +++ E
Sbjct: 4528 ERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4587
Query: 1564 IQAHGPRLEEVLERAGALASLRSPEAEAV--RRGLEQLQSAWAGL-REAAERRQQVLDAA 1620
+ +H ++ E L++ G S + + V + L +QS W + + ER + + DA
Sbjct: 4588 VNSHREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4646
Query: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSE-DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ +Q++ +++ WL E E + SE + D L +H + ++ +
Sbjct: 4647 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4706
Query: 1680 LSRQCRALLEMGH--PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLY-QLSRQV 1736
+R R+L E D+ ++ S++ + + ER+ LE+ Q + +
Sbjct: 4707 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4766
Query: 1737 SELEHWI--AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL 1794
L W+ E ++ P G D + V L + F E G + A+ + EL
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKR-TSSVQALKRSAREL 4824
Query: 1795 IECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSDARELQGQIEEK 1853
IE ++ + L+ W + L + + +L AA R+ +F S L + E
Sbjct: 4825 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4884
Query: 1854 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 1913
+ L P+ + ++ + F ++ L + +L + TV A H ++I
Sbjct: 4885 EQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSI 4941
Query: 1914 ASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LLSWMDGIASQIGAAD 1969
+ + + ++E+L+ + + ++S L ++ + LL+W+ + + D
Sbjct: 4942 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 5001
Query: 1970 K---PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDK- 2025
K P+++ V+ L+ HQ E+ + P++ + + + S++ I LDK
Sbjct: 5002 KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPV-LDKG 5060
Query: 2026 -LGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVA---DAWLTAQEPLLQSRELGSSVD 2081
G ++ S + Q +E +V+ WL A E + R+L ++D
Sbjct: 5061 RAGRKRFPASSLYP---SGSQTQIETKNPRVNLLVSKWQQVWLLALE---RRRKLNDALD 5114
Query: 2082 EVEQL 2086
+E+L
Sbjct: 5115 RLEEL 5119
Score = 95.1 bits (235), Expect = 8e-19
Identities = 188/971 (19%), Positives = 367/971 (37%), Gaps = 77/971 (7%)
Query: 301 LDQVLEVGKIIERYEELAAELLAWIHRTVG-LISNQKFANSLSGVQQQLQAFTAYCTLEK 359
+D++ E + +Y++ + W+ G L S L V+QQ++ + K
Sbjct: 4202 IDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQF----K 4257
Query: 360 PVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRA 419
+Q++ +E L + L+ + ++ W LE+ R+ L
Sbjct: 4258 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4317
Query: 420 ELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDN-FGYELPAVEAAMKKHEAIEADI 478
L L +F H + +WL + L+S+ G + A+E + KH ++ D+
Sbjct: 4318 AL-------LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4370
Query: 479 AAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQ-WALLTGLVGARRTRLEQNLAL 537
A++ V+ V + L + + VL Q W + R+ +L+ L
Sbjct: 4371 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4430
Query: 538 QKVFQ-EMVYMVDWMEEMQAQLL-SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALN 595
K F E+ + W+ + + LL S+ G A + L H + A+ E ++L
Sbjct: 4431 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4490
Query: 596 AAALRFSQLQGYQPCDPQV-ICNRVNHVHGCLAELQEQAARRRAELEASRSL-WALLQEL 653
Q+ P + I +N++ ++ + R+ +LE + +L L
Sbjct: 4491 QKG---QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4547
Query: 654 EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRA 713
++ +W E+ L A L + + +HK+ E+ R
Sbjct: 4548 QDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSHRE 4593
Query: 714 LLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEAR 773
+ + + G L + +V + S + RW+++ + R R L +AR
Sbjct: 4594 QIIELDKTGTHLKYF-------SQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4646
Query: 774 A-LHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSG 831
QF L++WL ++ + L + + +D + QH+ + A
Sbjct: 4647 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4706
Query: 832 LRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGE-V 890
R +L + + L + E + + + R+ L +AL F + +
Sbjct: 4707 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4766
Query: 891 HACELWIGEKEQWLLSMR-VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVE 949
A W+ E L + V +D V + ++ +E+ V + + +EL+E
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4826
Query: 950 GGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVL--LVENH--VLEVAEVRAQVRE 1005
G S V+ L++RW + L ++ + A L E H V + E A+ +
Sbjct: 4827 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ 4886
Query: 1006 KRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAAL----LAERFPAQAARLHQ 1061
R P AL+ + + ++ LE ++A L + + LA P +
Sbjct: 4887 TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4946
Query: 1062 GAEELGAEW-GALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP-LP 1119
+ A + LA A Q +A L L+A L WL A+ + +P
Sbjct: 4947 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5006
Query: 1120 NSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLEL 1179
+EE AL+A H EE+ +++ D ++ + AAD + +L +P L+
Sbjct: 5007 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKR-RAADPS------SLQSHIPVLDK 5059
Query: 1180 GWHKLLGLWEARREALVQAHIY------QLFLRDLRQALVVLRNQEMALSGAELPGTVES 1233
G A R+ + +Y Q+ ++ R L+V + Q++ L E +
Sbjct: 5060 G--------RAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLND 5111
Query: 1234 VEEALKQHRDF 1244
+ L++ R+F
Sbjct: 5112 ALDRLEELREF 5122
Score = 63.9 bits (154), Expect = 2e-09
Identities = 225/1161 (19%), Positives = 451/1161 (38%), Gaps = 194/1161 (16%)
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAV 1280
A++ + G V + E +F L+ K + + G G + ++ E
Sbjct: 2394 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMT-DISHGYEDLGLLLKDKIAELN 2452
Query: 1281 TRL--LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
T+L L+K QE QW+QK++ W + D
Sbjct: 2453 TKLSKLQKAQEESSAMMQWLQKMNKTATK------------W-------QQTPAPTDTEA 2493
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELE 1396
+ + ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL
Sbjct: 2494 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2553
Query: 1397 STTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQS 1454
T + ++L E+S Q A+L + L+ E + + P D +N+Q +++Q
Sbjct: 2554 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2613
Query: 1455 MESQVEEWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER 1507
+ ++E+ + + TAA P E P+ + +V E+ AV ++ L L +R
Sbjct: 2614 L---LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2670
Query: 1508 ----RRLLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLR 1561
+ ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q ++
Sbjct: 2671 CDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMK 2726
Query: 1562 REIQAHGPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+EIQ ++ + + E AL +AE + R LE + ++ + + AE Q L
Sbjct: 2727 QEIQQEKKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQ 2785
Query: 1619 AAFQVEQYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQ------LLKKHLQLEQGV- 1670
+A + ++ + +AWL ++ E++ K + + L+K H + +
Sbjct: 2786 SACASSHQFQQMSRDFQAWLDTKK-----EEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2840
Query: 1671 ---ENYEESIAQ-----LSRQC--RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 1720
YE++IA+ L Q +A L++ Q++ ++ D +KE + +
Sbjct: 2841 AQSHMYEKTIAEGENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKERENKLK 2894
Query: 1721 VALEQQY-----------WLYQLSRQVSELEHWIAEKE-------VVAGSPELGQDFEHV 1762
+LE+ W+ + + E++ + E + + E+ Q F V
Sbjct: 2895 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2954
Query: 1763 SVLQEKFSEFASETGM---AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAEL 1819
+L + S + + ++ Q VD + E H+ + + + + + E
Sbjct: 2955 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL----ENMTQKFKEF 3010
Query: 1820 LEL-MGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 1878
E+ ++ QL A +L D + G + L L T Q++L+
Sbjct: 3011 QEVSKESKRQLQCAKEQL-----DIHDSLGSQAYSNKYLTMLQT----------QQKSLQ 3055
Query: 1879 AFEHDLQLLVSQVRQLQEGAAQLR-TVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 1937
A +H + L + L A+ + T E IA + Q E S E
Sbjct: 3056 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3115
Query: 1938 VSSTADALRFHSQVRDLLSWMDGIASQIGA-ADKPRDVSSVEVLMNYHQGLKTELEARVP 1996
+ F + +R++ S ++ + A RD +++ + +LEA +
Sbjct: 3116 IG------HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMA 3169
Query: 1997 ELTTCQELGRSLLLNK-------------SAMADEIQAQLDKLGTRKEEVSEKWDRHWEW 2043
+ + +L + A++ + LD+ R+E+V R E+
Sbjct: 3170 SNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEF 3229
Query: 2044 LQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEER 2103
++ E Q+ A+E +G + + Q + + F+K
Sbjct: 3230 YSKLKEFSILLQK---------AEEHEESQGPVGMETETINQQLNMFKVFQK-------- 3272
Query: 2104 FSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPLARR 2163
E+I+ Q KQ LG+ L AA G E L+ + R
Sbjct: 3273 ----------EEIEPLQGKQQDVNWLGQ-------GLIQSAAKSTSTQGLEHDLDDVNAR 3315
Query: 2164 ASDTLSAEVRTRVGYVRQE-LKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPA 2222
TL+ +V R +++ L R Q ++ L + V+ L A + P
Sbjct: 3316 WK-TLNKKVAQRAAQLQEALLHCGRFQDALESL--LSWMVDTEELVANQK--------PP 3364
Query: 2223 AAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLT 2282
+AE + + QE ++L +R +R+ +V+ + + + + + + L+
Sbjct: 3365 SAEFKVVKAQIQE-----QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3419
Query: 2283 L--GRYEQMERRRERRERRLE 2301
L R+E + + E R R+LE
Sbjct: 3420 LLDSRWEALLNKAETRNRQLE 3440
Score = 61.2 bits (147), Expect = 1e-08
Identities = 331/1792 (18%), Positives = 673/1792 (37%), Gaps = 232/1792 (12%)
Query: 464 VEAAMKKHEAIEADIAAYEERVQGVAELAQALA-AEGYYDIRRVAAQR--DSVLRQWALL 520
++ +++ +A++ I++ + V+ + + A+ L A G + Q+ D ++ ++ L
Sbjct: 2025 LQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL 2084
Query: 521 TGLVGARRTRLEQNLALQKVFQE-MVYMVDWMEEMQAQLLSRECGQ---HLVEADDLLQK 576
+ V R +L+ L Q+ + M+DWM +++ L +E GQ + D++ K
Sbjct: 2085 SKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL--KEQGQVPLNSTALQDIISK 2142
Query: 577 HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARR 636
+ +LE DIA + + A+N +F ++ P + ++ + +E +
Sbjct: 2143 NIMLEQDIAGRQSSINAMNEKVKKF--METTDPSTASSLQAKMKDLSARFSEASHKHKET 2200
Query: 637 RAELEASRSLWALLQEL-EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTA 695
A++E ++ L + L E+ +++ K + L G T + ST+
Sbjct: 2201 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD------VPGKDVTELSQYMQESTS 2254
Query: 696 RLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRW 755
L K L+ + + L + LV E+ + +++
Sbjct: 2255 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVL------------------EKTNNLSKKF 2296
Query: 756 QRLEEAAARRERRLQEARA-LHQFGADLDGLLDWLRDAYRLA-------AAGDFGHDEAS 807
+ +E+ ++ + + L F + L W+++ + A D G
Sbjct: 2297 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2356
Query: 808 SRRLARQHRALTGEVEAHRGPVSGLRRQLATLG------GASGAGPLVVALQVRVVEAEQ 861
+++L + T E++ L ++ + A +G V+ + E+
Sbjct: 2357 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2416
Query: 862 LFA---------EVTEVAALRRQW---LRDALA--------VYRMFGEVHACELWIGEKE 901
+A ++T+++ L+D +A + + E A W+ +
Sbjct: 2417 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN 2476
Query: 902 QWLLSMRVPDSLDDVEVVQHRFE---SLDQEMNSLMGRVLDVNHTVQELVEGGH--PSSD 956
+ + + D E V+ + E S + E+ + +V ++ + EL+E P +
Sbjct: 2477 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2536
Query: 957 EVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRA 1016
+ ++S+W + +L R++++ N++ + V AQ+++ E
Sbjct: 2537 RWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQLKQWLVEKELMVSV 2593
Query: 1017 GGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGA------------- 1063
G L + L Q ++ LL+E A ++ Q QG
Sbjct: 2594 LGPLSIDPNMLNTQRQQVQ----ILLQEFATRKPQYE-QLTAAGQGILSRPGEDPSLRGI 2648
Query: 1064 --EELGA---EW----GALASAAQACGEAVAAAGRLQRFLHDLD---AFLDWLVRAQEAA 1111
E+L A +W G L+ +A+ + + Q L L + LD + + A
Sbjct: 2649 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2708
Query: 1112 GGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASE---ALLAADGAELGPGL 1168
+ LE A + K+E+ Q ++ A E AL+ + +
Sbjct: 2709 STHPDAMNQQLETAQKM-------KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2761
Query: 1169 ALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELP 1228
L+ L + K + + A +H +Q RD QA + + +E S +
Sbjct: 2762 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF-QAWLDTKKEEQNKSHP-IS 2819
Query: 1229 GTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQ 1288
++ +E +K H+DF T+ + + E LL + + A + ++ N
Sbjct: 2820 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2879
Query: 1289 EN-QLRAQQWMQKLHDQLE-LQHFLRDCHELDGWIH------EKMLMARDGTREDN---- 1336
+ + ++ KL + LE + L WI E++ D +N
Sbjct: 2880 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2939
Query: 1337 -HKLHKRWLRHQAFMAELAQN--KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
L K +H M EL N L E + + + E L V ++
Sbjct: 2940 LKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKF 2998
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGD-------LATVN 1446
LE+ TQ K ++ E SK E ++L + QL D G L +
Sbjct: 2999 CLENMTQ-KFKEFQEVSK---------ESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3048
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTA--------ALPLEPASKELVGERQNAVGERLV 1498
+Q K LQ+++ QV+ R +L + + L +E ++E Q V E+
Sbjct: 3049 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ-VDEKCS 3107
Query: 1499 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
L LQ +E+ + DDEL P+ E LQ ++ IK
Sbjct: 3108 FLETKLQGIGHFQNTIREMFSQFAEFDDEL---DSMAPVGRDAET---LQKQKETIKAFL 3161
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+ A + + A SP+ ++R LE L L + A+ R++ ++
Sbjct: 3162 KKLEALMASNDNANKTCKMMLATEE-TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVE 3220
Query: 1619 AAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL--QLLKKHLQLEQGVENYEE 1675
++E++Y + E L + E S+ E T+ QL + ++ +E +
Sbjct: 3221 GTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3280
Query: 1676 SIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY--Q 1731
++ + L++ S + +D + K L ++ +R A Q+ L+ +
Sbjct: 3281 KQQDVNWLGQGLIQSA-AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3339
Query: 1732 LSRQVSELEHWIAE-KEVVAGSPELGQDFEHV-------SVLQEKFSEFASETGMAGR-- 1781
+ L W+ + +E+VA +F+ V +LQ + S + R
Sbjct: 3340 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3399
Query: 1782 ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 1841
E++A + D+ ++ + + W+ LN+A +L G + +++ H+
Sbjct: 3400 EKIATTAEPADK-VKILKQLSLLDSRWEALLNKAETRNRQLEG----ISVVAQQFHETLE 3454
Query: 1842 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVRQLQEGA 1898
E IE+ RL AS ++ + +A E D+ + Q
Sbjct: 3455 PLNEWLTTIEK------RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3508
Query: 1899 AQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTA--DALRFHSQVRDLLS 1956
L+ + + E + + S+ + Q W + +R + A +A F +L++
Sbjct: 3509 QSLKVLSSREDKDMVQSK-LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3567
Query: 1957 WMDGIASQIGAADKPRDVSSVEVLMNYHQGL-KTELEARVPE---LTTCQELGRSLL--- 2009
W++ + ++ S + V +GL K + E RV + L Q + ++LL
Sbjct: 3568 WLNEVHDKL---------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGL 3618
Query: 2010 -LNKSAMADE---IQAQLDKLGTRKEEVSEKWDRHWEWLQQMLE----VHQFAQEAVVAD 2061
L K DE IQ +L+ + R +++++ + L+Q L+ +H +E
Sbjct: 3619 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC--- 3675
Query: 2062 AWLTAQEPLLQSRELG-SSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
WL E L S E +E Q R + +K A + SL +++
Sbjct: 3676 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3727
Score = 59.7 bits (143), Expect = 4e-08
Identities = 202/1022 (19%), Positives = 400/1022 (39%), Gaps = 160/1022 (15%)
Query: 1226 ELPGTVESVEEALKQHRDFLTTME---LSQ-QKMQVAVQAAEGLL-RQGNIYGEQAQEAV 1280
++ G V + +E L Q + +SQ Q + +A Q+A+ LL +QG + +E +
Sbjct: 1777 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1836
Query: 1281 TRLLEK---NQENQLRAQQWMQKLHDQL--ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+ +++ + E L + KL L EL+ F D E + W+ E+ L +
Sbjct: 1837 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1896
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 1386
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 1897 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1952
Query: 1387 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 1444
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 1953 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2009
Query: 1445 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 1484
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 2010 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2069
Query: 1485 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 1542
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2070 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2128
Query: 1543 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 1601
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2129 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2188
Query: 1602 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 1652
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2189 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2245
Query: 1653 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 1693
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2246 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2305
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 1753
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2306 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2348
Query: 1754 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 1811
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2349 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2403
Query: 1812 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2404 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2463
Query: 1866 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 1899
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2464 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2523
Query: 1900 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 1956
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2524 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2582
Query: 1957 WM---DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
W+ + + S +G D + + Q L E R P+ G+ +L
Sbjct: 2583 WLVEKELMVSVLGPLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2640
Query: 2014 ---AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAV--VADAWLTAQE 2068
++ ++ QL + + + ++ + +W+ Q + Q + ++D
Sbjct: 2641 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2700
Query: 2069 PLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERF-------SSLRRLTTIEKIKAEQS 2121
L S + + D + Q + + ++ +++ L L E +KAE S
Sbjct: 2701 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS 2760
Query: 2122 KQ 2123
+Q
Sbjct: 2761 RQ 2762
Score = 53.9 bits (128), Expect = 2e-06
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 1686
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 637 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 696
Query: 1687 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 1746
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 697 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 747
Query: 1747 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 1806
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 748 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 806
Query: 1807 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 1859
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 807 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 859
Score = 52.0 bits (123), Expect = 8e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 1372 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 1431
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 454 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 507
Query: 1432 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 1477
+ V G + T + + + + + G Q+ T +L
Sbjct: 508 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 567
Query: 1478 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 568 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 627
Query: 1521 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 628 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 687
Query: 1575 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 1633
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 688 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 740
Query: 1634 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 1693
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 741 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 800
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 1738
I E R A++ Q+ W+ QL + V +
Sbjct: 801 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 828
Score = 51.6 bits (122), Expect = 1e-05
Identities = 95/486 (19%), Positives = 202/486 (41%), Gaps = 66/486 (13%)
Query: 1215 LRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQV-AVQAAEGLLRQGNIYG 1273
+ ++E++ +L +++++ L +H D +T E ++ + QV +Q + LL ++
Sbjct: 1505 ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESL-- 1562
Query: 1274 EQAQEAVTRLLEKNQENQL--RAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDG 1331
+Q QE+ T K +E + R Q++ +KL +L + + L G H++ M DG
Sbjct: 1563 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL--LTQTENRLIG--HQEAFMIGDG 1618
Query: 1332 TRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 1385
T E +L K +AE+ +N E ++ G++L QE L + +KL
Sbjct: 1619 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL---IEQKL 1673
Query: 1386 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 1445
E + +L + ++L D++V + + + + + QL++ +
Sbjct: 1674 NEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE-----SKTKI 1722
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
+ L L +++ E + ++ Q E K +GE G LLE
Sbjct: 1723 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----LLET-- 1776
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
D+D ++ QE L Q + + + QH + +
Sbjct: 1777 -----------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH--------QAVI 1811
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVE 1624
+ +LE+ G S E E +++ +++L+ + L E+ ++ + ++E
Sbjct: 1812 IATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 1869
Query: 1625 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIAQLSRQ 1683
++ D E E WL + E + + + G D+ + L LK+ + V +++ + ++
Sbjct: 1870 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 1929
Query: 1684 CRALLE 1689
+LE
Sbjct: 1930 GNRVLE 1935
Score = 46.2 bits (108), Expect = 4e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 1429 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 1488
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 647 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 704
Query: 1489 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 1548
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 705 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 761
Query: 1549 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 1608
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 762 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 821
Query: 1609 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 1665
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 822 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 881
Query: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 1696
++ + Y+ +IA L + + ++++ +S+
Sbjct: 882 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 912
Score = 43.5 bits (101), Expect = 0.003
Identities = 166/929 (17%), Positives = 350/929 (37%), Gaps = 144/929 (15%)
Query: 1231 VESVEEALKQHRD-------FLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283
+E + ++LK +RD ++ +E +Q+K+Q L + +
Sbjct: 1314 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1373
Query: 1284 LEKNQENQLRAQQWMQKLHDQLELQHF----LRDCHELDGWIHEKMLMARDGTREDNHKL 1339
K E Q A+Q+ + D ELQ + D + +M + D ++ L
Sbjct: 1374 QSKMDECQKYAEQYSATVKDY-ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1432
Query: 1340 HKRWLRHQAFMAELAQNK-EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 1398
R+ M + + + L+++E E + L +EK E ++ Q W S
Sbjct: 1433 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISK 1487
Query: 1399 TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQS 1454
T A + + + Q + S E+ K + LQ + GD T + + +L+
Sbjct: 1488 TLKDAEKAGKPPFSKQKISS-EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEK 1545
Query: 1455 MESQVEEWYR-----EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 1509
++E Y + +LQ + ++ K +V ERQ E+L + + L +
Sbjct: 1546 QVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTEN 1604
Query: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----I 1564
L+ +E + D EL Q + +Q + QA+ + +K + +E
Sbjct: 1605 RLIGHQEAFMIG-DGTVELKKYQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1662
Query: 1565 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS-----------AWAGLREAAERR 1613
Q +E+ L A + +AE ++ L+++ + A L E+ +
Sbjct: 1663 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKI 1722
Query: 1614 QQVLDAAFQVEQ-----------------YYFDVAEVEAWLGEQE-----LLMMSEDK-- 1649
+ +LD V++ +F + ++ +GE++ LL D
Sbjct: 1723 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQV 1782
Query: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQ 1704
G +++ Q +K + + + +++ ++ + LLE + + E++ + +
Sbjct: 1783 GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1842
Query: 1705 VDRLY-VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 1763
+ Y AL E ++ ++ Q L + +E EHW+ + E + E G D +
Sbjct: 1843 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1902
Query: 1764 VLQEKFSEFASETGMAGRERLAAV----NQMVDELIECGH------TAAATMAEWKDGLN 1813
+ + K + SE ++ + L + N++++ C +AT E + L+
Sbjct: 1903 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1962
Query: 1814 EAWAELLEL-------------------------MGTRAQLLAASRELHKFFS-----DA 1843
A L G A L A K S D
Sbjct: 1963 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2022
Query: 1844 RELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT 1903
+ LQ Q+EE + ++ SS Q + + ++L+ L ++
Sbjct: 2023 KNLQRQLEETKALQGQI----------SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ- 2071
Query: 1904 VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIAS 1963
+ + I R +++ + E + +L ++ T +L + ++L WM + S
Sbjct: 2072 ----KTLDDIVGRYEDLSKSVNE-----RNEKLQITLTR-SLSVQDGLDEMLDWMGNVES 2121
Query: 1964 QIGAADK-PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLL-LNKSAMADEIQA 2021
+ + P + ++++ +++ + L+ ++ R + E + + + A +QA
Sbjct: 2122 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2181
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
++ L R E S K H E L +M E+
Sbjct: 2182 KMKDLSARFSEASHK---HKETLAKMEEL 2207
Score = 41.2 bits (95), Expect = 0.013
Identities = 120/590 (20%), Positives = 243/590 (41%), Gaps = 113/590 (19%)
Query: 1260 QAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRA--QQWMQKLHDQLELQHFLRDCHEL 1317
QAAE L++ +Y + E + +KN L + +QW ++ ++ ++ H L D +
Sbjct: 1211 QAAEALVK---LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1267
Query: 1318 DGWIHEKMLMAR-------DGTREDNHKLHKRWLRHQAFMAELAQNKE------------ 1358
I ++M D +E +L +RW + ++ E
Sbjct: 1268 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1327
Query: 1359 ------WLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKA 1412
W++++E +++ + +PE + ++ +L + + +E+E + SK
Sbjct: 1328 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKM 1377
Query: 1413 DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGEL 1469
D+ Q +AE + + +LQ + A V+SQ K K + M+S + +E +L
Sbjct: 1378 DE-CQKYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1432
Query: 1470 QAQTAALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLD 1525
+ + AL L+ + G+ L RL E +E++ + +KEL + ++
Sbjct: 1433 RTRYTAL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1486
Query: 1526 DELAWVQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGA 1580
L ++ + P + Q + ++ + + Q ++ + HG ++ EE E
Sbjct: 1487 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1546
Query: 1581 LASLRSPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYY 1627
+ +L+ L+QLQ + +E E+ Q + D Q E
Sbjct: 1547 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE--- 1603
Query: 1628 FDVAEVEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ES 1676
+G QE M+ + + K QS + L+K +Q L + V+N E E+
Sbjct: 1604 ------NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1657
Query: 1677 IAQLSRQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQY 1727
+LS++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q
Sbjct: 1658 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ- 1714
Query: 1728 WLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 1777
L + ++ L W++ V S G +H V+++ + F G
Sbjct: 1715 -LEESKTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1759
Score = 40.4 bits (93), Expect = 0.023
Identities = 66/340 (19%), Positives = 137/340 (40%), Gaps = 44/340 (12%)
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAAS--------RELHKFFSDARELQGQIEEKRRRLPR 1859
+ G+ + L+LM R LL +S E++ F ++L ++E + +L R
Sbjct: 596 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKF--VQDLLNWVDEMQVQLDR 653
Query: 1860 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQE 1919
T PS S + ++ S +++ + Q+ +AE + E +
Sbjct: 654 -TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQ 712
Query: 1920 VLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV 1979
+ +LL+ + H+ + + F S+ + L W++ + A D +++
Sbjct: 713 ----YAKLLNTSRNQERHLDTLHN---FVSRATNELIWLNEKEEEEVAYDWSERNTNIAR 765
Query: 1980 LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDR 2039
+YH L EL+ + + + QE+ LLL I+A + T+
Sbjct: 766 KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQ---------- 815
Query: 2040 HWEWLQQM---LEVH--------QFAQEAVVADAWLTAQEPLLQ---SRELGSSVDEVEQ 2085
W W+ Q+ +E H +F +A A +L + +Q S + SS+ ++E
Sbjct: 816 -WSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLED 874
Query: 2086 LIRRHEAFRKAAAAWEERFSSLR-RLTTIEKIKAEQSKQP 2124
L++ ++ ++ ++L + TI ++K S P
Sbjct: 875 LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP 914
Score = 37.4 bits (85), Expect = 0.19
Identities = 34/177 (19%), Positives = 74/177 (41%), Gaps = 8/177 (4%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
+L + E + L ++ L+ L F + WLNE + + + +
Sbjct: 705 KLHRLESQYAKLLNTSRNQERHLDTL-HNFVSRATNELIWLNEKEE--EEVAYDWSERNT 761
Query: 465 EAAMKK--HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTG 522
A KK H + ++ EE ++ V E+A+ L E + + A R ++ QW+ +
Sbjct: 762 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 821
Query: 523 LVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQL---LSRECGQHLVEADDLLQK 576
L +++N A + F + D++ ++ + S + + + +DL+Q+
Sbjct: 822 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 878
Score = 36.2 bits (82), Expect = 0.43
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 8/130 (6%)
Query: 1132 HAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEAR 1191
HA L E+DQ+EE+ + +E LL + L ++ + ++ W +L L +
Sbjct: 770 HAELMRELDQKEENIKSVQEIAEQLLLENHP---ARLTIEAYRAAMQTQWSWILQLCQCV 826
Query: 1192 REALVQAHIYQLFLRDLRQALVVLRNQEMALS---GAELPGTVESVEEALKQHRDFLTTM 1248
+ + + Y F D ++A LRN + A+ + ++ +E+ +++ +
Sbjct: 827 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME--EKE 884
Query: 1249 ELSQQKMQVA 1258
EL Q K +A
Sbjct: 885 ELLQYKSTIA 894
Score = 32.3 bits (72), Expect = 6.2
Identities = 16/48 (33%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 531 LEQNLALQKVFQEMVY-MVDWMEEMQAQLLSRECGQHLVEADDLLQKH 577
L+QNL +++ + V +++W++EMQ QL E G L + L+ H
Sbjct: 623 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENH 670
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 295 bits (755), Expect = 4e-79
Identities = 191/468 (40%), Positives = 270/468 (57%), Gaps = 30/468 (6%)
Query: 55 LADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGR 114
+ADER+ VQKKTFTKW+N HL +V H+ DLY DLRDG L LLEVLSG+ LPR +GR
Sbjct: 69 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 127
Query: 115 MRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETE 174
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI I + E
Sbjct: 128 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 187
Query: 175 DNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTK 234
E SAK+ LLLW Q T GY + +NFTT WRDG FNA+IH++RPDL+D + +
Sbjct: 188 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245
Query: 235 SNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEG 294
+ NL+ AF AE+ +G+ RLLDPEDV++ +PDEKS+ITYV S Y F K+ G
Sbjct: 246 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 301
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
+ IG +V K IE Y+ + L+ WI V +S + F N+ ++ + +
Sbjct: 302 EGIGANDVEV----KWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 356
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
E P K EK ++ L ++ + +L +G DI+K WG+L A ERE
Sbjct: 357 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 413
Query: 415 AALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAI 474
ALR E+ R E L+ +A R R+S + E++ +++ + + +E+ ++
Sbjct: 414 KALRPEVERLEMLQQIANR-----VQRDSVICEDKLILAGNALQSDSKRLESGVQFQN-- 466
Query: 475 EADIAAY----EERVQGVAELAQALAAEGYYD----IRRVAAQRDSVL 514
EA+IA Y E ++ Q L YY ++RVA RD ++
Sbjct: 467 EAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIM 514
Score = 142 bits (358), Expect = 4e-33
Identities = 396/1970 (20%), Positives = 766/1970 (38%), Gaps = 190/1970 (9%)
Query: 242 QRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVL 301
Q++ + + + LA+ L +D+ +EA D K ++ + L+ + L
Sbjct: 3062 QKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFL 3120
Query: 302 DQVLE-VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKP 360
+ L+ +G E+ ++ + + + A +L ++ ++AF L+K
Sbjct: 3121 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF-----LKK- 3174
Query: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
LE L+ S + + C L + I + +LE + L
Sbjct: 3175 --------LEALMASNDNANKTCKMMLATEETSPDLVGIKR---DLEALSKQCNKLLDRA 3223
Query: 421 LIRQEKLELLAQRFDHKVAMRESWL----NENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
R+E++E +R + + + + + SQ G E + + + +
Sbjct: 3224 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3283
Query: 477 D-IAAYEERVQGVAELAQAL--AAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQ 533
+ I + + Q V L Q L +A + + D V +W L V R +L++
Sbjct: 3284 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3343
Query: 534 NLALQKVFQEMVY-MVDWM---EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE 589
L FQ+ + ++ WM EE+ A +V+A +Q+ LL+ + +
Sbjct: 3344 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ--IQEQKLLQRLLDDRKS 3401
Query: 590 RVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649
VE + + + +P D I +++ + L +A R +LE +
Sbjct: 3402 TVEVIKREGEKIATTA--EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3459
Query: 650 LQE-LEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGEL 708
E LE W E+ L G S +AQHK L+ ++
Sbjct: 3460 FHETLEPLNEWLTTIEKRLVNCEPIGTQA--------------SKLEEQIAQHKALEDDI 3505
Query: 709 GGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQ-RLEEAAARRER 767
L QA+ G+ L + + + W ++E + R
Sbjct: 3506 INHNKHLHQAVSIGQSLKVLSSREDK--------DMVQSKLDFSQVWYIEIQEKSHSRSE 3557
Query: 768 RLQEARALHQ-FGADLDGLLDWLRDAY-RLAAAGDFGHDEASSRRLARQHRALTGEVEAH 825
LQ+A + FG D L++WL + + +L+ + + + R L ++
Sbjct: 3558 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
Query: 826 RGPV-SGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVY 884
+ V L L L +G L++ ++ ++A + ++T+++ + L AL +
Sbjct: 3618 KQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR--YKDITKLSTDVAKTLEQALQLA 3675
Query: 885 RMFGEVHACEL--WIGEKEQWLLSMRVPD-SLDDVEVVQHRFESLDQEM---NSLMGRVL 938
R H EL W+ + E LLS ++ Q R + L +E +L+ +
Sbjct: 3676 RRLHSTHE-ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3734
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE 998
+V+ + ELV E +D N R+ + + + Q+ EE+ A +L + A+
Sbjct: 3735 EVSSALLELVPWRAREGLEKMVAED--NERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3792
Query: 999 VR-AQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAA 1057
+ + E + + S G ++ A LQ + +L ++ + +
Sbjct: 3793 AELSWITETEKKLMSL----GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3848
Query: 1058 RLHQGAEE--------LGAEWGALASAAQACGEAVAAAGRLQ----RFLHDLDAFLDWLV 1105
+ +EE L + Q E R Q +F + WL
Sbjct: 3849 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3908
Query: 1106 RAQEAAGGSEGPLPN-SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAEL 1164
Q S+ P P E H L+E + + + ++ LL
Sbjct: 3909 ETQSII--SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP--- 3963
Query: 1165 GPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRD-LRQALVVL-RNQEMAL 1222
G G ++ E + + ++ + R AL +A D + Q L L R E
Sbjct: 3964 GEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4023
Query: 1223 SGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQG-----NIYGEQAQ 1277
+ VE ++E + ++++ ME Q + Q E ++ + +I + Q
Sbjct: 4024 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4083
Query: 1278 EAVTRLLEKNQENQLRAQQWMQKLHDQLEL-QHFLRDCHELDGWIHEKMLMARDGTREDN 1336
+ + +++ + ++ KL D +EL + F D L I + RD ++
Sbjct: 4084 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD---LED 4140
Query: 1337 HKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS--------VRKKLGEI 1388
+ ++ Q AE +E ++ ++ E ++ EL A+ V+K + E+
Sbjct: 4141 PGIDPSVVKQQQEAAETI--REEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4198
Query: 1389 RQCWAELESTTQAKARQLFEASKA-----DQLVQSFAELDKKLLHMESQLQDVDP-GGDL 1442
W L + + +L EA +A D L F +D +L + P G DL
Sbjct: 4199 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD----IAGGKLASMSPIGTDL 4254
Query: 1443 ATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-- 1500
TV Q+++L+ +S+ + E+ L Q A L L+ ++E ++ V + L+ L
Sbjct: 4255 ETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEE---SDKHTVQDPLMELKL 4310
Query: 1501 -LEPLQER-----RRLLLASKELHQVAHDLDDELAWV--QERLPLAMQTERGNGLQAVQQ 1552
+ L+ER +L A L Q H LD+ LAW+ E L L+ Q G +A++
Sbjct: 4311 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-LSEQKPVGGDPKAIEI 4369
Query: 1553 HIKKNQGLRREIQAHGPRLEEVLERAG--ALASLRSPEAEAVRRGLEQLQSAWAGLREAA 1610
+ K+ L+ ++ AH +E V +AG + S EA ++ LE L W + E
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAV-NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4428
Query: 1611 ERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQEL-LMMSEDKGKDEQSTLQLLKKHLQLEQ 1668
E+R+Q LD A Q + ++ ++ +++ WL + E L+ S+ G ++ + L H+++
Sbjct: 4429 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4488
Query: 1669 GVENYEESIAQLSRQCRALLEMGHPDSE-QISRRQSQVDRLYVALKELGEERRVALEQQY 1727
E EE+ L ++ + +L +E I + + + + +++ ER+ LE+
Sbjct: 4489 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4548
Query: 1728 WL-YQLSRQVSELEHWIAEKEV---VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 1783
L + + + +W+ + E VA P L D + + K FA+E + RE+
Sbjct: 4549 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVN-SHREQ 4605
Query: 1784 LAAVNQMVDELIECGHTAAATMAE-WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD 1842
+ +++ L + + + W ++++ + R + L +R+ K F +
Sbjct: 4606 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4665
Query: 1843 A-RELQGQIEEKRRRLP---RLTTPPEPRPSA----SSMQRTLRAFEHDLQLLVSQVRQL 1894
A +L +EE + L + P+ + Q++L A R L
Sbjct: 4666 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725
Query: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD- 1953
+E +T A ++ + + E+ W + C + + +AL F Q D
Sbjct: 4726 KE-----KTSLADDNLK-LDDMLSELRDKWDTI---CGKSVERQNKLEEALLFSGQFTDA 4776
Query: 1954 ---LLSWMDGIASQIGAADKP--RDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSL 2008
L+ W+ + Q+ A D+P D+ V L++ H+ + EL R + + R L
Sbjct: 4777 LQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4835
Query: 2009 LLNKSAMADEIQAQLDKLGTRKEEVS----EKWDRHWEWLQQMLEVHQFAQEAVVADAWL 2064
+ + ++ Q+ +L TR E V K R L+Q E H + WL
Sbjct: 4836 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL---EWL 4892
Query: 2065 TAQEPLLQSR-ELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTI 2113
E L+ L D + LI +H+ F K EE+ + L + TT+
Sbjct: 4893 AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 4939
Score = 118 bits (295), Expect = 9e-26
Identities = 352/1865 (18%), Positives = 745/1865 (39%), Gaps = 139/1865 (7%)
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
K++ + Q+ E R+++ LL+W+ T L++NQK ++ V +
Sbjct: 3332 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK-------- 3383
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
+ QE+ L+ LL +S + R D K +L + E
Sbjct: 3384 ------AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3437
Query: 415 AALRAELIRQEKLE---LLAQRFDHKVAMRESWLNE-NQRLVSQDNFGYELPAVEAAMKK 470
A L R +LE ++AQ+F + WL +RLV+ + G + +E + +
Sbjct: 3438 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQ 3497
Query: 471 HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARRT 529
H+A+E DI + + + + Q+L + + + + + W + + +R
Sbjct: 3498 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3557
Query: 530 RLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH-GLLEGDIAAQ 587
L+Q L K+F ++ V +++W+ E+ +L + E Q +L+ DI +
Sbjct: 3558 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3617
Query: 588 SERVEA--LNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAE-LEASR 644
+ V+ LN L Q G + Q + + + +L A+ + L+ +R
Sbjct: 3618 KQNVDQALLNGLEL-LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3676
Query: 645 SLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKIL 704
L + +EL +W E L + G + +S A++ + K L
Sbjct: 3677 RLHSTHEELC---TWLDKVEVELLSYETQVLKG------------EEASQAQM--RPKEL 3719
Query: 705 QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAAR 764
+ E +ALL + L A+ GL + A R++ + + +
Sbjct: 3720 KKEAKNNKALL-------DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3772
Query: 765 RERRLQEA-RALHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEV 822
+ + A QF D L W+ + + L + GD ++ + + + T E+
Sbjct: 3773 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3832
Query: 823 EAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALA 882
H+ + L + + A +++ ++ + + + + ++ + R L A +
Sbjct: 3833 LRHKDIIDDLVKSGHKIMTACSEEEKQ-SMKKKLDKVLKNYDTICQINSERYLQLERAQS 3891
Query: 883 VYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGR----VL 938
+ F E + ELW E + ++P + E ++ + E +++ L+ +
Sbjct: 3892 LVNQFWETYE-ELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHID 3949
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRK----EEMSAVLLVENHVL 994
+N T +L+E ++ ++ +++I E V++R E +S + +
Sbjct: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4009
Query: 995 EVAEVRAQVREKRRAVESAPRAGGALQWRLS---GLEAALQALEPRQAALLEEAALLAER 1051
++ E ++ E+ R S ++ ++S + ++ L+P L + + R
Sbjct: 4010 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4069
Query: 1052 FPA-----QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL-QRFLHDLDAFLDWLV 1105
A + +++ W + + + + L ++F D + + +
Sbjct: 4070 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4129
Query: 1106 RAQEAAGGSEGPLPNSLEEADALLARHAA--LKEEVDQREEDYARIVAASEALLAADGAE 1163
Q+ E P ++ + + AA ++EE+D +E+ ++ L+AA G
Sbjct: 4130 DTQDFIRDLEDP---GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4186
Query: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQAL---VVLRNQEM 1220
P + + + L W L W+ R + L +A + +D QA+ V + ++
Sbjct: 4187 DKP--IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4244
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLR----QGNIYGEQA 1276
A S + + +E+V++ +++ + F + Q +M+ AE LL+ + + + Q
Sbjct: 4245 A-SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4303
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQL-ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+L+ + E ++ +Q KL L L F EL W+ E +L +
Sbjct: 4304 PLMELKLIWDSLEERIINRQ--HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4361
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCW 1392
D + +H ++ ++ +E + + G L++ E A++++ KL + Q W
Sbjct: 4362 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4421
Query: 1393 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VN 1446
+ T+ + +QL A + A +L + L E L P G L +N
Sbjct: 4422 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN 4481
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQ 1505
++ + E++ EE Y+ + +Q L P S E + + N + E+ + L
Sbjct: 4482 VHMEVCAAFEAK-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLN 4538
Query: 1506 ERRRLLLASKELHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 1563
ER+ L + L H+ L D + W+ Q L + + L V I +++ E
Sbjct: 4539 ERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4598
Query: 1564 IQAHGPRLEEVLERAGALASLRSPEAEAV--RRGLEQLQSAWAGL-REAAERRQQVLDAA 1620
+ +H ++ E L++ G S + + V + L +QS W + + ER + + DA
Sbjct: 4599 VNSHREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4657
Query: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSE-DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ +Q++ +++ WL E E + SE + D L +H + ++ +
Sbjct: 4658 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4717
Query: 1680 LSRQCRALLEMGH--PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLY-QLSRQV 1736
+R R+L E D+ ++ S++ + + ER+ LE+ Q + +
Sbjct: 4718 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4777
Query: 1737 SELEHWI--AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL 1794
L W+ E ++ P G D + V L + F E G + A+ + EL
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKR-TSSVQALKRSAREL 4835
Query: 1795 IECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSDARELQGQIEEK 1853
IE ++ + L+ W + L + + +L AA R+ +F S L + E
Sbjct: 4836 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4895
Query: 1854 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 1913
+ L P+ + ++ + F ++ L + +L + TV A H ++I
Sbjct: 4896 EQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSI 4952
Query: 1914 ASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LLSWMDGIASQIGAAD 1969
+ + + ++E+L+ + + ++S L ++ + LL+W+ + + D
Sbjct: 4953 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 5012
Query: 1970 K---PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDK- 2025
K P+++ V+ L+ HQ E+ + P++ + + + S++ I LDK
Sbjct: 5013 KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPV-LDKG 5071
Query: 2026 -LGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVA---DAWLTAQEPLLQSRELGSSVD 2081
G ++ S + Q +E +V+ WL A E + R+L ++D
Sbjct: 5072 RAGRKRFPASSLYP---SGSQTQIETKNPRVNLLVSKWQQVWLLALE---RRRKLNDALD 5125
Query: 2082 EVEQL 2086
+E+L
Sbjct: 5126 RLEEL 5130
Score = 95.1 bits (235), Expect = 8e-19
Identities = 188/971 (19%), Positives = 367/971 (37%), Gaps = 77/971 (7%)
Query: 301 LDQVLEVGKIIERYEELAAELLAWIHRTVG-LISNQKFANSLSGVQQQLQAFTAYCTLEK 359
+D++ E + +Y++ + W+ G L S L V+QQ++ + K
Sbjct: 4213 IDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQF----K 4268
Query: 360 PVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRA 419
+Q++ +E L + L+ + ++ W LE+ R+ L
Sbjct: 4269 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4328
Query: 420 ELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDN-FGYELPAVEAAMKKHEAIEADI 478
L L +F H + +WL + L+S+ G + A+E + KH ++ D+
Sbjct: 4329 AL-------LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4381
Query: 479 AAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQ-WALLTGLVGARRTRLEQNLAL 537
A++ V+ V + L + + VL Q W + R+ +L+ L
Sbjct: 4382 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4441
Query: 538 QKVFQ-EMVYMVDWMEEMQAQLL-SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALN 595
K F E+ + W+ + + LL S+ G A + L H + A+ E ++L
Sbjct: 4442 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4501
Query: 596 AAALRFSQLQGYQPCDPQV-ICNRVNHVHGCLAELQEQAARRRAELEASRSL-WALLQEL 653
Q+ P + I +N++ ++ + R+ +LE + +L L
Sbjct: 4502 QKG---QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4558
Query: 654 EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRA 713
++ +W E+ L A L + + +HK+ E+ R
Sbjct: 4559 QDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSHRE 4604
Query: 714 LLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEAR 773
+ + + G L + +V + S + RW+++ + R R L +AR
Sbjct: 4605 QIIELDKTGTHLKYF-------SQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4657
Query: 774 A-LHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSG 831
QF L++WL ++ + L + + +D + QH+ + A
Sbjct: 4658 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4717
Query: 832 LRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGE-V 890
R +L + + L + E + + + R+ L +AL F + +
Sbjct: 4718 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4777
Query: 891 HACELWIGEKEQWLLSMR-VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVE 949
A W+ E L + V +D V + ++ +E+ V + + +EL+E
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4837
Query: 950 GGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVL--LVENH--VLEVAEVRAQVRE 1005
G S V+ L++RW + L ++ + A L E H V + E A+ +
Sbjct: 4838 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ 4897
Query: 1006 KRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAAL----LAERFPAQAARLHQ 1061
R P AL+ + + ++ LE ++A L + + LA P +
Sbjct: 4898 TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4957
Query: 1062 GAEELGAEW-GALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP-LP 1119
+ A + LA A Q +A L L+A L WL A+ + +P
Sbjct: 4958 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5017
Query: 1120 NSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLEL 1179
+EE AL+A H EE+ +++ D ++ + AAD + +L +P L+
Sbjct: 5018 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKR-RAADPS------SLQSHIPVLDK 5070
Query: 1180 GWHKLLGLWEARREALVQAHIY------QLFLRDLRQALVVLRNQEMALSGAELPGTVES 1233
G A R+ + +Y Q+ ++ R L+V + Q++ L E +
Sbjct: 5071 G--------RAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLND 5122
Query: 1234 VEEALKQHRDF 1244
+ L++ R+F
Sbjct: 5123 ALDRLEELREF 5133
Score = 63.9 bits (154), Expect = 2e-09
Identities = 225/1161 (19%), Positives = 451/1161 (38%), Gaps = 194/1161 (16%)
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAV 1280
A++ + G V + E +F L+ K + + G G + ++ E
Sbjct: 2405 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMT-DISHGYEDLGLLLKDKIAELN 2463
Query: 1281 TRL--LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
T+L L+K QE QW+QK++ W + D
Sbjct: 2464 TKLSKLQKAQEESSAMMQWLQKMNKTATK------------W-------QQTPAPTDTEA 2504
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELE 1396
+ + ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL
Sbjct: 2505 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2564
Query: 1397 STTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQS 1454
T + ++L E+S Q A+L + L+ E + + P D +N+Q +++Q
Sbjct: 2565 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2624
Query: 1455 MESQVEEWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER 1507
+ ++E+ + + TAA P E P+ + +V E+ AV ++ L L +R
Sbjct: 2625 L---LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2681
Query: 1508 ----RRLLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLR 1561
+ ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q ++
Sbjct: 2682 CDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMK 2737
Query: 1562 REIQAHGPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+EIQ ++ + + E AL +AE + R LE + ++ + + AE Q L
Sbjct: 2738 QEIQQEKKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQ 2796
Query: 1619 AAFQVEQYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQ------LLKKHLQLEQGV- 1670
+A + ++ + +AWL ++ E++ K + + L+K H + +
Sbjct: 2797 SACASSHQFQQMSRDFQAWLDTKK-----EEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2851
Query: 1671 ---ENYEESIAQ-----LSRQC--RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 1720
YE++IA+ L Q +A L++ Q++ ++ D +KE + +
Sbjct: 2852 AQSHMYEKTIAEGENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKERENKLK 2905
Query: 1721 VALEQQY-----------WLYQLSRQVSELEHWIAEKE-------VVAGSPELGQDFEHV 1762
+LE+ W+ + + E++ + E + + E+ Q F V
Sbjct: 2906 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2965
Query: 1763 SVLQEKFSEFASETGM---AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAEL 1819
+L + S + + ++ Q VD + E H+ + + + + + E
Sbjct: 2966 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL----ENMTQKFKEF 3021
Query: 1820 LEL-MGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 1878
E+ ++ QL A +L D + G + L L T Q++L+
Sbjct: 3022 QEVSKESKRQLQCAKEQL-----DIHDSLGSQAYSNKYLTMLQT----------QQKSLQ 3066
Query: 1879 AFEHDLQLLVSQVRQLQEGAAQLR-TVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 1937
A +H + L + L A+ + T E IA + Q E S E
Sbjct: 3067 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3126
Query: 1938 VSSTADALRFHSQVRDLLSWMDGIASQIGA-ADKPRDVSSVEVLMNYHQGLKTELEARVP 1996
+ F + +R++ S ++ + A RD +++ + +LEA +
Sbjct: 3127 IG------HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMA 3180
Query: 1997 ELTTCQELGRSLLLNK-------------SAMADEIQAQLDKLGTRKEEVSEKWDRHWEW 2043
+ + +L + A++ + LD+ R+E+V R E+
Sbjct: 3181 SNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEF 3240
Query: 2044 LQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEER 2103
++ E Q+ A+E +G + + Q + + F+K
Sbjct: 3241 YSKLKEFSILLQK---------AEEHEESQGPVGMETETINQQLNMFKVFQK-------- 3283
Query: 2104 FSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPLARR 2163
E+I+ Q KQ LG+ L AA G E L+ + R
Sbjct: 3284 ----------EEIEPLQGKQQDVNWLGQ-------GLIQSAAKSTSTQGLEHDLDDVNAR 3326
Query: 2164 ASDTLSAEVRTRVGYVRQE-LKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPA 2222
TL+ +V R +++ L R Q ++ L + V+ L A + P
Sbjct: 3327 WK-TLNKKVAQRAAQLQEALLHCGRFQDALESL--LSWMVDTEELVANQK--------PP 3375
Query: 2223 AAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLT 2282
+AE + + QE ++L +R +R+ +V+ + + + + + + L+
Sbjct: 3376 SAEFKVVKAQIQE-----QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3430
Query: 2283 L--GRYEQMERRRERRERRLE 2301
L R+E + + E R R+LE
Sbjct: 3431 LLDSRWEALLNKAETRNRQLE 3451
Score = 61.2 bits (147), Expect = 1e-08
Identities = 331/1792 (18%), Positives = 673/1792 (37%), Gaps = 232/1792 (12%)
Query: 464 VEAAMKKHEAIEADIAAYEERVQGVAELAQALA-AEGYYDIRRVAAQR--DSVLRQWALL 520
++ +++ +A++ I++ + V+ + + A+ L A G + Q+ D ++ ++ L
Sbjct: 2036 LQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL 2095
Query: 521 TGLVGARRTRLEQNLALQKVFQE-MVYMVDWMEEMQAQLLSRECGQ---HLVEADDLLQK 576
+ V R +L+ L Q+ + M+DWM +++ L +E GQ + D++ K
Sbjct: 2096 SKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL--KEQGQVPLNSTALQDIISK 2153
Query: 577 HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARR 636
+ +LE DIA + + A+N +F ++ P + ++ + +E +
Sbjct: 2154 NIMLEQDIAGRQSSINAMNEKVKKF--METTDPSTASSLQAKMKDLSARFSEASHKHKET 2211
Query: 637 RAELEASRSLWALLQEL-EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTA 695
A++E ++ L + L E+ +++ K + L G T + ST+
Sbjct: 2212 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD------VPGKDVTELSQYMQESTS 2265
Query: 696 RLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRW 755
L K L+ + + L + LV E+ + +++
Sbjct: 2266 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVL------------------EKTNNLSKKF 2307
Query: 756 QRLEEAAARRERRLQEARA-LHQFGADLDGLLDWLRDAYRLA-------AAGDFGHDEAS 807
+ +E+ ++ + + L F + L W+++ + A D G
Sbjct: 2308 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2367
Query: 808 SRRLARQHRALTGEVEAHRGPVSGLRRQLATLG------GASGAGPLVVALQVRVVEAEQ 861
+++L + T E++ L ++ + A +G V+ + E+
Sbjct: 2368 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2427
Query: 862 LFA---------EVTEVAALRRQW---LRDALA--------VYRMFGEVHACELWIGEKE 901
+A ++T+++ L+D +A + + E A W+ +
Sbjct: 2428 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN 2487
Query: 902 QWLLSMRVPDSLDDVEVVQHRFE---SLDQEMNSLMGRVLDVNHTVQELVEGGH--PSSD 956
+ + + D E V+ + E S + E+ + +V ++ + EL+E P +
Sbjct: 2488 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2547
Query: 957 EVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRA 1016
+ ++S+W + +L R++++ N++ + V AQ+++ E
Sbjct: 2548 RWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQLKQWLVEKELMVSV 2604
Query: 1017 GGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGA------------- 1063
G L + L Q ++ LL+E A ++ Q QG
Sbjct: 2605 LGPLSIDPNMLNTQRQQVQ----ILLQEFATRKPQYE-QLTAAGQGILSRPGEDPSLRGI 2659
Query: 1064 --EELGA---EW----GALASAAQACGEAVAAAGRLQRFLHDLD---AFLDWLVRAQEAA 1111
E+L A +W G L+ +A+ + + Q L L + LD + + A
Sbjct: 2660 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2719
Query: 1112 GGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASE---ALLAADGAELGPGL 1168
+ LE A + K+E+ Q ++ A E AL+ + +
Sbjct: 2720 STHPDAMNQQLETAQKM-------KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2772
Query: 1169 ALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELP 1228
L+ L + K + + A +H +Q RD QA + + +E S +
Sbjct: 2773 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF-QAWLDTKKEEQNKSHP-IS 2830
Query: 1229 GTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQ 1288
++ +E +K H+DF T+ + + E LL + + A + ++ N
Sbjct: 2831 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2890
Query: 1289 EN-QLRAQQWMQKLHDQLE-LQHFLRDCHELDGWIH------EKMLMARDGTREDN---- 1336
+ + ++ KL + LE + L WI E++ D +N
Sbjct: 2891 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2950
Query: 1337 -HKLHKRWLRHQAFMAELAQN--KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
L K +H M EL N L E + + + E L V ++
Sbjct: 2951 LKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKF 3009
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGD-------LATVN 1446
LE+ TQ K ++ E SK E ++L + QL D G L +
Sbjct: 3010 CLENMTQ-KFKEFQEVSK---------ESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3059
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTA--------ALPLEPASKELVGERQNAVGERLV 1498
+Q K LQ+++ QV+ R +L + + L +E ++E Q V E+
Sbjct: 3060 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ-VDEKCS 3118
Query: 1499 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
L LQ +E+ + DDEL P+ E LQ ++ IK
Sbjct: 3119 FLETKLQGIGHFQNTIREMFSQFAEFDDEL---DSMAPVGRDAET---LQKQKETIKAFL 3172
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+ A + + A SP+ ++R LE L L + A+ R++ ++
Sbjct: 3173 KKLEALMASNDNANKTCKMMLATEE-TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVE 3231
Query: 1619 AAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL--QLLKKHLQLEQGVENYEE 1675
++E++Y + E L + E S+ E T+ QL + ++ +E +
Sbjct: 3232 GTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3291
Query: 1676 SIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY--Q 1731
++ + L++ S + +D + K L ++ +R A Q+ L+ +
Sbjct: 3292 KQQDVNWLGQGLIQSA-AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3350
Query: 1732 LSRQVSELEHWIAE-KEVVAGSPELGQDFEHV-------SVLQEKFSEFASETGMAGR-- 1781
+ L W+ + +E+VA +F+ V +LQ + S + R
Sbjct: 3351 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3410
Query: 1782 ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 1841
E++A + D+ ++ + + W+ LN+A +L G + +++ H+
Sbjct: 3411 EKIATTAEPADK-VKILKQLSLLDSRWEALLNKAETRNRQLEG----ISVVAQQFHETLE 3465
Query: 1842 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVRQLQEGA 1898
E IE+ RL AS ++ + +A E D+ + Q
Sbjct: 3466 PLNEWLTTIEK------RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3519
Query: 1899 AQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTA--DALRFHSQVRDLLS 1956
L+ + + E + + S+ + Q W + +R + A +A F +L++
Sbjct: 3520 QSLKVLSSREDKDMVQSK-LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3578
Query: 1957 WMDGIASQIGAADKPRDVSSVEVLMNYHQGL-KTELEARVPE---LTTCQELGRSLL--- 2009
W++ + ++ S + V +GL K + E RV + L Q + ++LL
Sbjct: 3579 WLNEVHDKL---------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGL 3629
Query: 2010 -LNKSAMADE---IQAQLDKLGTRKEEVSEKWDRHWEWLQQMLE----VHQFAQEAVVAD 2061
L K DE IQ +L+ + R +++++ + L+Q L+ +H +E
Sbjct: 3630 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC--- 3686
Query: 2062 AWLTAQEPLLQSRELG-SSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
WL E L S E +E Q R + +K A + SL +++
Sbjct: 3687 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3738
Score = 59.7 bits (143), Expect = 4e-08
Identities = 202/1022 (19%), Positives = 400/1022 (39%), Gaps = 160/1022 (15%)
Query: 1226 ELPGTVESVEEALKQHRDFLTTME---LSQ-QKMQVAVQAAEGLL-RQGNIYGEQAQEAV 1280
++ G V + +E L Q + +SQ Q + +A Q+A+ LL +QG + +E +
Sbjct: 1788 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1847
Query: 1281 TRLLEK---NQENQLRAQQWMQKLHDQL--ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+ +++ + E L + KL L EL+ F D E + W+ E+ L +
Sbjct: 1848 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1907
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 1386
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 1908 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1963
Query: 1387 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 1444
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 1964 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2020
Query: 1445 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 1484
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 2021 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2080
Query: 1485 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 1542
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2081 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2139
Query: 1543 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 1601
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2140 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2199
Query: 1602 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 1652
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2200 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2256
Query: 1653 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 1693
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2257 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2316
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 1753
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2317 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2359
Query: 1754 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 1811
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2360 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2414
Query: 1812 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2415 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2474
Query: 1866 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 1899
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2475 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2534
Query: 1900 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 1956
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2535 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2593
Query: 1957 WM---DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
W+ + + S +G D + + Q L E R P+ G+ +L
Sbjct: 2594 WLVEKELMVSVLGPLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2651
Query: 2014 ---AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAV--VADAWLTAQE 2068
++ ++ QL + + + ++ + +W+ Q + Q + ++D
Sbjct: 2652 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2711
Query: 2069 PLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERF-------SSLRRLTTIEKIKAEQS 2121
L S + + D + Q + + ++ +++ L L E +KAE S
Sbjct: 2712 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS 2771
Query: 2122 KQ 2123
+Q
Sbjct: 2772 RQ 2773
Score = 53.9 bits (128), Expect = 2e-06
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 1686
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 648 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 707
Query: 1687 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 1746
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 708 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 758
Query: 1747 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 1806
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 759 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 817
Query: 1807 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 1859
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 818 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 870
Score = 52.0 bits (123), Expect = 8e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 1372 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 1431
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 465 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 518
Query: 1432 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 1477
+ V G + T + + + + + G Q+ T +L
Sbjct: 519 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 578
Query: 1478 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 579 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 638
Query: 1521 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 639 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 698
Query: 1575 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 1633
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 699 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 751
Query: 1634 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 1693
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 752 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 811
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 1738
I E R A++ Q+ W+ QL + V +
Sbjct: 812 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 839
Score = 51.6 bits (122), Expect = 1e-05
Identities = 95/486 (19%), Positives = 202/486 (41%), Gaps = 66/486 (13%)
Query: 1215 LRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQV-AVQAAEGLLRQGNIYG 1273
+ ++E++ +L +++++ L +H D +T E ++ + QV +Q + LL ++
Sbjct: 1516 ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESL-- 1573
Query: 1274 EQAQEAVTRLLEKNQENQL--RAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDG 1331
+Q QE+ T K +E + R Q++ +KL +L + + L G H++ M DG
Sbjct: 1574 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL--LTQTENRLIG--HQEAFMIGDG 1629
Query: 1332 TRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 1385
T E +L K +AE+ +N E ++ G++L QE L + +KL
Sbjct: 1630 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL---IEQKL 1684
Query: 1386 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 1445
E + +L + ++L D++V + + + + + QL++ +
Sbjct: 1685 NEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE-----SKTKI 1733
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
+ L L +++ E + ++ Q E K +GE G LLE
Sbjct: 1734 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----LLET-- 1787
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
D+D ++ QE L Q + + + QH + +
Sbjct: 1788 -----------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH--------QAVI 1822
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVE 1624
+ +LE+ G S E E +++ +++L+ + L E+ ++ + ++E
Sbjct: 1823 IATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 1880
Query: 1625 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIAQLSRQ 1683
++ D E E WL + E + + + G D+ + L LK+ + V +++ + ++
Sbjct: 1881 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 1940
Query: 1684 CRALLE 1689
+LE
Sbjct: 1941 GNRVLE 1946
Score = 46.2 bits (108), Expect = 4e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 1429 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 1488
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 658 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 715
Query: 1489 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 1548
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 716 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 772
Query: 1549 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 1608
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 773 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 832
Query: 1609 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 1665
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 833 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 892
Query: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 1696
++ + Y+ +IA L + + ++++ +S+
Sbjct: 893 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 923
Score = 43.5 bits (101), Expect = 0.003
Identities = 166/929 (17%), Positives = 350/929 (37%), Gaps = 144/929 (15%)
Query: 1231 VESVEEALKQHRD-------FLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283
+E + ++LK +RD ++ +E +Q+K+Q L + +
Sbjct: 1325 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1384
Query: 1284 LEKNQENQLRAQQWMQKLHDQLELQHF----LRDCHELDGWIHEKMLMARDGTREDNHKL 1339
K E Q A+Q+ + D ELQ + D + +M + D ++ L
Sbjct: 1385 QSKMDECQKYAEQYSATVKDY-ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1443
Query: 1340 HKRWLRHQAFMAELAQNK-EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 1398
R+ M + + + L+++E E + L +EK E ++ Q W S
Sbjct: 1444 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISK 1498
Query: 1399 TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQS 1454
T A + + + Q + S E+ K + LQ + GD T + + +L+
Sbjct: 1499 TLKDAEKAGKPPFSKQKISS-EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEK 1556
Query: 1455 MESQVEEWYR-----EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 1509
++E Y + +LQ + ++ K +V ERQ E+L + + L +
Sbjct: 1557 QVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTEN 1615
Query: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----I 1564
L+ +E + D EL Q + +Q + QA+ + +K + +E
Sbjct: 1616 RLIGHQEAFMIG-DGTVELKKYQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1673
Query: 1565 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS-----------AWAGLREAAERR 1613
Q +E+ L A + +AE ++ L+++ + A L E+ +
Sbjct: 1674 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKI 1733
Query: 1614 QQVLDAAFQVEQ-----------------YYFDVAEVEAWLGEQE-----LLMMSEDK-- 1649
+ +LD V++ +F + ++ +GE++ LL D
Sbjct: 1734 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQV 1793
Query: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQ 1704
G +++ Q +K + + + +++ ++ + LLE + + E++ + +
Sbjct: 1794 GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1853
Query: 1705 VDRLY-VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 1763
+ Y AL E ++ ++ Q L + +E EHW+ + E + E G D +
Sbjct: 1854 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1913
Query: 1764 VLQEKFSEFASETGMAGRERLAAV----NQMVDELIECGH------TAAATMAEWKDGLN 1813
+ + K + SE ++ + L + N++++ C +AT E + L+
Sbjct: 1914 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973
Query: 1814 EAWAELLEL-------------------------MGTRAQLLAASRELHKFFS-----DA 1843
A L G A L A K S D
Sbjct: 1974 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2033
Query: 1844 RELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT 1903
+ LQ Q+EE + ++ SS Q + + ++L+ L ++
Sbjct: 2034 KNLQRQLEETKALQGQI----------SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ- 2082
Query: 1904 VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIAS 1963
+ + I R +++ + E + +L ++ T +L + ++L WM + S
Sbjct: 2083 ----KTLDDIVGRYEDLSKSVNE-----RNEKLQITLTR-SLSVQDGLDEMLDWMGNVES 2132
Query: 1964 QIGAADK-PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLL-LNKSAMADEIQA 2021
+ + P + ++++ +++ + L+ ++ R + E + + + A +QA
Sbjct: 2133 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2192
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
++ L R E S K H E L +M E+
Sbjct: 2193 KMKDLSARFSEASHK---HKETLAKMEEL 2218
Score = 41.2 bits (95), Expect = 0.013
Identities = 120/590 (20%), Positives = 243/590 (41%), Gaps = 113/590 (19%)
Query: 1260 QAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRA--QQWMQKLHDQLELQHFLRDCHEL 1317
QAAE L++ +Y + E + +KN L + +QW ++ ++ ++ H L D +
Sbjct: 1222 QAAEALVK---LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1278
Query: 1318 DGWIHEKMLMAR-------DGTREDNHKLHKRWLRHQAFMAELAQNKE------------ 1358
I ++M D +E +L +RW + ++ E
Sbjct: 1279 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1338
Query: 1359 ------WLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKA 1412
W++++E +++ + +PE + ++ +L + + +E+E + SK
Sbjct: 1339 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKM 1388
Query: 1413 DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGEL 1469
D+ Q +AE + + +LQ + A V+SQ K K + M+S + +E +L
Sbjct: 1389 DE-CQKYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1443
Query: 1470 QAQTAALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLD 1525
+ + AL L+ + G+ L RL E +E++ + +KEL + ++
Sbjct: 1444 RTRYTAL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1497
Query: 1526 DELAWVQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGA 1580
L ++ + P + Q + ++ + + Q ++ + HG ++ EE E
Sbjct: 1498 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1557
Query: 1581 LASLRSPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYY 1627
+ +L+ L+QLQ + +E E+ Q + D Q E
Sbjct: 1558 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE--- 1614
Query: 1628 FDVAEVEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ES 1676
+G QE M+ + + K QS + L+K +Q L + V+N E E+
Sbjct: 1615 ------NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1668
Query: 1677 IAQLSRQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQY 1727
+LS++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q
Sbjct: 1669 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ- 1725
Query: 1728 WLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 1777
L + ++ L W++ V S G +H V+++ + F G
Sbjct: 1726 -LEESKTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1770
Score = 40.4 bits (93), Expect = 0.023
Identities = 66/340 (19%), Positives = 137/340 (40%), Gaps = 44/340 (12%)
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAAS--------RELHKFFSDARELQGQIEEKRRRLPR 1859
+ G+ + L+LM R LL +S E++ F ++L ++E + +L R
Sbjct: 607 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKF--VQDLLNWVDEMQVQLDR 664
Query: 1860 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQE 1919
T PS S + ++ S +++ + Q+ +AE + E +
Sbjct: 665 -TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQ 723
Query: 1920 VLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV 1979
+ +LL+ + H+ + + F S+ + L W++ + A D +++
Sbjct: 724 ----YAKLLNTSRNQERHLDTLHN---FVSRATNELIWLNEKEEEEVAYDWSERNTNIAR 776
Query: 1980 LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDR 2039
+YH L EL+ + + + QE+ LLL I+A + T+
Sbjct: 777 KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQ---------- 826
Query: 2040 HWEWLQQM---LEVH--------QFAQEAVVADAWLTAQEPLLQ---SRELGSSVDEVEQ 2085
W W+ Q+ +E H +F +A A +L + +Q S + SS+ ++E
Sbjct: 827 -WSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLED 885
Query: 2086 LIRRHEAFRKAAAAWEERFSSLR-RLTTIEKIKAEQSKQP 2124
L++ ++ ++ ++L + TI ++K S P
Sbjct: 886 LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP 925
Score = 37.4 bits (85), Expect = 0.19
Identities = 34/177 (19%), Positives = 74/177 (41%), Gaps = 8/177 (4%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
+L + E + L ++ L+ L F + WLNE + + + +
Sbjct: 716 KLHRLESQYAKLLNTSRNQERHLDTL-HNFVSRATNELIWLNEKEE--EEVAYDWSERNT 772
Query: 465 EAAMKK--HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTG 522
A KK H + ++ EE ++ V E+A+ L E + + A R ++ QW+ +
Sbjct: 773 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 832
Query: 523 LVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQL---LSRECGQHLVEADDLLQK 576
L +++N A + F + D++ ++ + S + + + +DL+Q+
Sbjct: 833 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 889
Score = 36.2 bits (82), Expect = 0.43
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 8/130 (6%)
Query: 1132 HAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEAR 1191
HA L E+DQ+EE+ + +E LL + L ++ + ++ W +L L +
Sbjct: 781 HAELMRELDQKEENIKSVQEIAEQLLLENHP---ARLTIEAYRAAMQTQWSWILQLCQCV 837
Query: 1192 REALVQAHIYQLFLRDLRQALVVLRNQEMALS---GAELPGTVESVEEALKQHRDFLTTM 1248
+ + + Y F D ++A LRN + A+ + ++ +E+ +++ +
Sbjct: 838 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME--EKE 895
Query: 1249 ELSQQKMQVA 1258
EL Q K +A
Sbjct: 896 ELLQYKSTIA 905
Score = 32.3 bits (72), Expect = 6.2
Identities = 16/48 (33%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 531 LEQNLALQKVFQEMVY-MVDWMEEMQAQLLSRECGQHLVEADDLLQKH 577
L+QNL +++ + V +++W++EMQ QL E G L + L+ H
Sbjct: 634 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENH 681
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 295 bits (755), Expect = 4e-79
Identities = 191/468 (40%), Positives = 270/468 (57%), Gaps = 30/468 (6%)
Query: 55 LADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGR 114
+ADER+ VQKKTFTKW+N HL +V H+ DLY DLRDG L LLEVLSG+ LPR +GR
Sbjct: 207 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 265
Query: 115 MRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETE 174
MR H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI I + E
Sbjct: 266 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 325
Query: 175 DNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTK 234
E SAK+ LLLW Q T GY + +NFTT WRDG FNA+IH++RPDL+D + +
Sbjct: 326 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 383
Query: 235 SNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEG 294
+ NL+ AF AE+ +G+ RLLDPEDV++ +PDEKS+ITYV S Y F K+ G
Sbjct: 384 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GG 439
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
+ IG +V K IE Y+ + L+ WI V +S + F N+ ++ + +
Sbjct: 440 EGIGANDVEV----KWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 494
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
E P K EK ++ L ++ + +L +G DI+K WG+L A ERE
Sbjct: 495 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 551
Query: 415 AALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAI 474
ALR E+ R E L+ +A R R+S + E++ +++ + + +E+ ++
Sbjct: 552 KALRPEVERLEMLQQIANR-----VQRDSVICEDKLILAGNALQSDSKRLESGVQFQN-- 604
Query: 475 EADIAAY----EERVQGVAELAQALAAEGYYD----IRRVAAQRDSVL 514
EA+IA Y E ++ Q L YY ++RVA RD ++
Sbjct: 605 EAEIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIM 652
Score = 142 bits (358), Expect = 4e-33
Identities = 396/1970 (20%), Positives = 766/1970 (38%), Gaps = 190/1970 (9%)
Query: 242 QRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVL 301
Q++ + + + LA+ L +D+ +EA D K ++ + L+ + L
Sbjct: 3200 QKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFL 3258
Query: 302 DQVLE-VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKP 360
+ L+ +G E+ ++ + + + A +L ++ ++AF L+K
Sbjct: 3259 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF-----LKK- 3312
Query: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
LE L+ S + + C L + I + +LE + L
Sbjct: 3313 --------LEALMASNDNANKTCKMMLATEETSPDLVGIKR---DLEALSKQCNKLLDRA 3361
Query: 421 LIRQEKLELLAQRFDHKVAMRESWL----NENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
R+E++E +R + + + + + SQ G E + + + +
Sbjct: 3362 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3421
Query: 477 D-IAAYEERVQGVAELAQAL--AAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQ 533
+ I + + Q V L Q L +A + + D V +W L V R +L++
Sbjct: 3422 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3481
Query: 534 NLALQKVFQEMVY-MVDWM---EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE 589
L FQ+ + ++ WM EE+ A +V+A +Q+ LL+ + +
Sbjct: 3482 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ--IQEQKLLQRLLDDRKS 3539
Query: 590 RVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649
VE + + + +P D I +++ + L +A R +LE +
Sbjct: 3540 TVEVIKREGEKIATTA--EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3597
Query: 650 LQE-LEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGEL 708
E LE W E+ L G S +AQHK L+ ++
Sbjct: 3598 FHETLEPLNEWLTTIEKRLVNCEPIGTQA--------------SKLEEQIAQHKALEDDI 3643
Query: 709 GGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQ-RLEEAAARRER 767
L QA+ G+ L + + + W ++E + R
Sbjct: 3644 INHNKHLHQAVSIGQSLKVLSSREDK--------DMVQSKLDFSQVWYIEIQEKSHSRSE 3695
Query: 768 RLQEARALHQ-FGADLDGLLDWLRDAY-RLAAAGDFGHDEASSRRLARQHRALTGEVEAH 825
LQ+A + FG D L++WL + + +L+ + + + R L ++
Sbjct: 3696 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3755
Query: 826 RGPV-SGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVY 884
+ V L L L +G L++ ++ ++A + ++T+++ + L AL +
Sbjct: 3756 KQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR--YKDITKLSTDVAKTLEQALQLA 3813
Query: 885 RMFGEVHACEL--WIGEKEQWLLSMRVPD-SLDDVEVVQHRFESLDQEM---NSLMGRVL 938
R H EL W+ + E LLS ++ Q R + L +E +L+ +
Sbjct: 3814 RRLHSTHE-ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3872
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE 998
+V+ + ELV E +D N R+ + + + Q+ EE+ A +L + A+
Sbjct: 3873 EVSSALLELVPWRAREGLEKMVAED--NERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3930
Query: 999 VR-AQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAA 1057
+ + E + + S G ++ A LQ + +L ++ + +
Sbjct: 3931 AELSWITETEKKLMSL----GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3986
Query: 1058 RLHQGAEE--------LGAEWGALASAAQACGEAVAAAGRLQ----RFLHDLDAFLDWLV 1105
+ +EE L + Q E R Q +F + WL
Sbjct: 3987 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 4046
Query: 1106 RAQEAAGGSEGPLPN-SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAEL 1164
Q S+ P P E H L+E + + + ++ LL
Sbjct: 4047 ETQSII--SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP--- 4101
Query: 1165 GPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRD-LRQALVVL-RNQEMAL 1222
G G ++ E + + ++ + R AL +A D + Q L L R E
Sbjct: 4102 GEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 4161
Query: 1223 SGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQG-----NIYGEQAQ 1277
+ VE ++E + ++++ ME Q + Q E ++ + +I + Q
Sbjct: 4162 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4221
Query: 1278 EAVTRLLEKNQENQLRAQQWMQKLHDQLEL-QHFLRDCHELDGWIHEKMLMARDGTREDN 1336
+ + +++ + ++ KL D +EL + F D L I + RD ++
Sbjct: 4222 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD---LED 4278
Query: 1337 HKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS--------VRKKLGEI 1388
+ ++ Q AE +E ++ ++ E ++ EL A+ V+K + E+
Sbjct: 4279 PGIDPSVVKQQQEAAETI--REEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4336
Query: 1389 RQCWAELESTTQAKARQLFEASKA-----DQLVQSFAELDKKLLHMESQLQDVDP-GGDL 1442
W L + + +L EA +A D L F +D +L + P G DL
Sbjct: 4337 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD----IAGGKLASMSPIGTDL 4392
Query: 1443 ATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-- 1500
TV Q+++L+ +S+ + E+ L Q A L L+ ++E ++ V + L+ L
Sbjct: 4393 ETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEE---SDKHTVQDPLMELKL 4448
Query: 1501 -LEPLQER-----RRLLLASKELHQVAHDLDDELAWV--QERLPLAMQTERGNGLQAVQQ 1552
+ L+ER +L A L Q H LD+ LAW+ E L L+ Q G +A++
Sbjct: 4449 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-LSEQKPVGGDPKAIEI 4507
Query: 1553 HIKKNQGLRREIQAHGPRLEEVLERAG--ALASLRSPEAEAVRRGLEQLQSAWAGLREAA 1610
+ K+ L+ ++ AH +E V +AG + S EA ++ LE L W + E
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAV-NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4566
Query: 1611 ERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQEL-LMMSEDKGKDEQSTLQLLKKHLQLEQ 1668
E+R+Q LD A Q + ++ ++ +++ WL + E L+ S+ G ++ + L H+++
Sbjct: 4567 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4626
Query: 1669 GVENYEESIAQLSRQCRALLEMGHPDSE-QISRRQSQVDRLYVALKELGEERRVALEQQY 1727
E EE+ L ++ + +L +E I + + + + +++ ER+ LE+
Sbjct: 4627 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4686
Query: 1728 WL-YQLSRQVSELEHWIAEKEV---VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 1783
L + + + +W+ + E VA P L D + + K FA+E + RE+
Sbjct: 4687 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVN-SHREQ 4743
Query: 1784 LAAVNQMVDELIECGHTAAATMAE-WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD 1842
+ +++ L + + + W ++++ + R + L +R+ K F +
Sbjct: 4744 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4803
Query: 1843 A-RELQGQIEEKRRRLP---RLTTPPEPRPSA----SSMQRTLRAFEHDLQLLVSQVRQL 1894
A +L +EE + L + P+ + Q++L A R L
Sbjct: 4804 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863
Query: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD- 1953
+E +T A ++ + + E+ W + C + + +AL F Q D
Sbjct: 4864 KE-----KTSLADDNLK-LDDMLSELRDKWDTI---CGKSVERQNKLEEALLFSGQFTDA 4914
Query: 1954 ---LLSWMDGIASQIGAADKP--RDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSL 2008
L+ W+ + Q+ A D+P D+ V L++ H+ + EL R + + R L
Sbjct: 4915 LQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4973
Query: 2009 LLNKSAMADEIQAQLDKLGTRKEEVS----EKWDRHWEWLQQMLEVHQFAQEAVVADAWL 2064
+ + ++ Q+ +L TR E V K R L+Q E H + WL
Sbjct: 4974 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL---EWL 5030
Query: 2065 TAQEPLLQSR-ELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTI 2113
E L+ L D + LI +H+ F K EE+ + L + TT+
Sbjct: 5031 AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 5077
Score = 118 bits (295), Expect = 9e-26
Identities = 352/1865 (18%), Positives = 745/1865 (39%), Gaps = 139/1865 (7%)
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
K++ + Q+ E R+++ LL+W+ T L++NQK ++ V +
Sbjct: 3470 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK-------- 3521
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
+ QE+ L+ LL +S + R D K +L + E
Sbjct: 3522 ------AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3575
Query: 415 AALRAELIRQEKLE---LLAQRFDHKVAMRESWLNE-NQRLVSQDNFGYELPAVEAAMKK 470
A L R +LE ++AQ+F + WL +RLV+ + G + +E + +
Sbjct: 3576 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQ 3635
Query: 471 HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARRT 529
H+A+E DI + + + + Q+L + + + + + W + + +R
Sbjct: 3636 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3695
Query: 530 RLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH-GLLEGDIAAQ 587
L+Q L K+F ++ V +++W+ E+ +L + E Q +L+ DI +
Sbjct: 3696 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3755
Query: 588 SERVEA--LNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAE-LEASR 644
+ V+ LN L Q G + Q + + + +L A+ + L+ +R
Sbjct: 3756 KQNVDQALLNGLEL-LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3814
Query: 645 SLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKIL 704
L + +EL +W E L + G + +S A++ + K L
Sbjct: 3815 RLHSTHEELC---TWLDKVEVELLSYETQVLKG------------EEASQAQM--RPKEL 3857
Query: 705 QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAAR 764
+ E +ALL + L A+ GL + A R++ + + +
Sbjct: 3858 KKEAKNNKALL-------DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3910
Query: 765 RERRLQEA-RALHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEV 822
+ + A QF D L W+ + + L + GD ++ + + + T E+
Sbjct: 3911 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3970
Query: 823 EAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALA 882
H+ + L + + A +++ ++ + + + + ++ + R L A +
Sbjct: 3971 LRHKDIIDDLVKSGHKIMTACSEEEKQ-SMKKKLDKVLKNYDTICQINSERYLQLERAQS 4029
Query: 883 VYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGR----VL 938
+ F E + ELW E + ++P + E ++ + E +++ L+ +
Sbjct: 4030 LVNQFWETYE-ELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHID 4087
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRK----EEMSAVLLVENHVL 994
+N T +L+E ++ ++ +++I E V++R E +S + +
Sbjct: 4088 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4147
Query: 995 EVAEVRAQVREKRRAVESAPRAGGALQWRLS---GLEAALQALEPRQAALLEEAALLAER 1051
++ E ++ E+ R S ++ ++S + ++ L+P L + + R
Sbjct: 4148 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4207
Query: 1052 FPA-----QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL-QRFLHDLDAFLDWLV 1105
A + +++ W + + + + L ++F D + + +
Sbjct: 4208 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4267
Query: 1106 RAQEAAGGSEGPLPNSLEEADALLARHAA--LKEEVDQREEDYARIVAASEALLAADGAE 1163
Q+ E P ++ + + AA ++EE+D +E+ ++ L+AA G
Sbjct: 4268 DTQDFIRDLEDP---GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4324
Query: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQAL---VVLRNQEM 1220
P + + + L W L W+ R + L +A + +D QA+ V + ++
Sbjct: 4325 DKP--IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4382
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLR----QGNIYGEQA 1276
A S + + +E+V++ +++ + F + Q +M+ AE LL+ + + + Q
Sbjct: 4383 A-SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4441
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQL-ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+L+ + E ++ +Q KL L L F EL W+ E +L +
Sbjct: 4442 PLMELKLIWDSLEERIINRQ--HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4499
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCW 1392
D + +H ++ ++ +E + + G L++ E A++++ KL + Q W
Sbjct: 4500 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4559
Query: 1393 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VN 1446
+ T+ + +QL A + A +L + L E L P G L +N
Sbjct: 4560 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN 4619
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQ 1505
++ + E++ EE Y+ + +Q L P S E + + N + E+ + L
Sbjct: 4620 VHMEVCAAFEAK-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLN 4676
Query: 1506 ERRRLLLASKELHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 1563
ER+ L + L H+ L D + W+ Q L + + L V I +++ E
Sbjct: 4677 ERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4736
Query: 1564 IQAHGPRLEEVLERAGALASLRSPEAEAV--RRGLEQLQSAWAGL-REAAERRQQVLDAA 1620
+ +H ++ E L++ G S + + V + L +QS W + + ER + + DA
Sbjct: 4737 VNSHREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4795
Query: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSE-DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ +Q++ +++ WL E E + SE + D L +H + ++ +
Sbjct: 4796 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4855
Query: 1680 LSRQCRALLEMGH--PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLY-QLSRQV 1736
+R R+L E D+ ++ S++ + + ER+ LE+ Q + +
Sbjct: 4856 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4915
Query: 1737 SELEHWI--AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL 1794
L W+ E ++ P G D + V L + F E G + A+ + EL
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKR-TSSVQALKRSAREL 4973
Query: 1795 IECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSDARELQGQIEEK 1853
IE ++ + L+ W + L + + +L AA R+ +F S L + E
Sbjct: 4974 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 5033
Query: 1854 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 1913
+ L P+ + ++ + F ++ L + +L + TV A H ++I
Sbjct: 5034 EQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSI 5090
Query: 1914 ASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LLSWMDGIASQIGAAD 1969
+ + + ++E+L+ + + ++S L ++ + LL+W+ + + D
Sbjct: 5091 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 5150
Query: 1970 K---PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDK- 2025
K P+++ V+ L+ HQ E+ + P++ + + + S++ I LDK
Sbjct: 5151 KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPV-LDKG 5209
Query: 2026 -LGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVA---DAWLTAQEPLLQSRELGSSVD 2081
G ++ S + Q +E +V+ WL A E + R+L ++D
Sbjct: 5210 RAGRKRFPASSLYP---SGSQTQIETKNPRVNLLVSKWQQVWLLALE---RRRKLNDALD 5263
Query: 2082 EVEQL 2086
+E+L
Sbjct: 5264 RLEEL 5268
Score = 95.1 bits (235), Expect = 8e-19
Identities = 188/971 (19%), Positives = 367/971 (37%), Gaps = 77/971 (7%)
Query: 301 LDQVLEVGKIIERYEELAAELLAWIHRTVG-LISNQKFANSLSGVQQQLQAFTAYCTLEK 359
+D++ E + +Y++ + W+ G L S L V+QQ++ + K
Sbjct: 4351 IDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQF----K 4406
Query: 360 PVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRA 419
+Q++ +E L + L+ + ++ W LE+ R+ L
Sbjct: 4407 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4466
Query: 420 ELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDN-FGYELPAVEAAMKKHEAIEADI 478
L L +F H + +WL + L+S+ G + A+E + KH ++ D+
Sbjct: 4467 AL-------LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4519
Query: 479 AAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQ-WALLTGLVGARRTRLEQNLAL 537
A++ V+ V + L + + VL Q W + R+ +L+ L
Sbjct: 4520 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4579
Query: 538 QKVFQ-EMVYMVDWMEEMQAQLL-SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALN 595
K F E+ + W+ + + LL S+ G A + L H + A+ E ++L
Sbjct: 4580 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4639
Query: 596 AAALRFSQLQGYQPCDPQV-ICNRVNHVHGCLAELQEQAARRRAELEASRSL-WALLQEL 653
Q+ P + I +N++ ++ + R+ +LE + +L L
Sbjct: 4640 QKG---QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4696
Query: 654 EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRA 713
++ +W E+ L A L + + +HK+ E+ R
Sbjct: 4697 QDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSHRE 4742
Query: 714 LLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEAR 773
+ + + G L + +V + S + RW+++ + R R L +AR
Sbjct: 4743 QIIELDKTGTHLKYF-------SQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4795
Query: 774 A-LHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSG 831
QF L++WL ++ + L + + +D + QH+ + A
Sbjct: 4796 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4855
Query: 832 LRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGE-V 890
R +L + + L + E + + + R+ L +AL F + +
Sbjct: 4856 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4915
Query: 891 HACELWIGEKEQWLLSMR-VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVE 949
A W+ E L + V +D V + ++ +E+ V + + +EL+E
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4975
Query: 950 GGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVL--LVENH--VLEVAEVRAQVRE 1005
G S V+ L++RW + L ++ + A L E H V + E A+ +
Sbjct: 4976 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ 5035
Query: 1006 KRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAAL----LAERFPAQAARLHQ 1061
R P AL+ + + ++ LE ++A L + + LA P +
Sbjct: 5036 TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 5095
Query: 1062 GAEELGAEW-GALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP-LP 1119
+ A + LA A Q +A L L+A L WL A+ + +P
Sbjct: 5096 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5155
Query: 1120 NSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLEL 1179
+EE AL+A H EE+ +++ D ++ + AAD + +L +P L+
Sbjct: 5156 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKR-RAADPS------SLQSHIPVLDK 5208
Query: 1180 GWHKLLGLWEARREALVQAHIY------QLFLRDLRQALVVLRNQEMALSGAELPGTVES 1233
G A R+ + +Y Q+ ++ R L+V + Q++ L E +
Sbjct: 5209 G--------RAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLND 5260
Query: 1234 VEEALKQHRDF 1244
+ L++ R+F
Sbjct: 5261 ALDRLEELREF 5271
Score = 63.9 bits (154), Expect = 2e-09
Identities = 225/1161 (19%), Positives = 451/1161 (38%), Gaps = 194/1161 (16%)
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAV 1280
A++ + G V + E +F L+ K + + G G + ++ E
Sbjct: 2543 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMT-DISHGYEDLGLLLKDKIAELN 2601
Query: 1281 TRL--LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
T+L L+K QE QW+QK++ W + D
Sbjct: 2602 TKLSKLQKAQEESSAMMQWLQKMNKTATK------------W-------QQTPAPTDTEA 2642
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELE 1396
+ + ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL
Sbjct: 2643 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2702
Query: 1397 STTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQS 1454
T + ++L E+S Q A+L + L+ E + + P D +N+Q +++Q
Sbjct: 2703 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2762
Query: 1455 MESQVEEWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER 1507
+ ++E+ + + TAA P E P+ + +V E+ AV ++ L L +R
Sbjct: 2763 L---LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2819
Query: 1508 ----RRLLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLR 1561
+ ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q ++
Sbjct: 2820 CDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMK 2875
Query: 1562 REIQAHGPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+EIQ ++ + + E AL +AE + R LE + ++ + + AE Q L
Sbjct: 2876 QEIQQEKKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQ 2934
Query: 1619 AAFQVEQYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQ------LLKKHLQLEQGV- 1670
+A + ++ + +AWL ++ E++ K + + L+K H + +
Sbjct: 2935 SACASSHQFQQMSRDFQAWLDTKK-----EEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2989
Query: 1671 ---ENYEESIAQ-----LSRQC--RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 1720
YE++IA+ L Q +A L++ Q++ ++ D +KE + +
Sbjct: 2990 AQSHMYEKTIAEGENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKERENKLK 3043
Query: 1721 VALEQQY-----------WLYQLSRQVSELEHWIAEKE-------VVAGSPELGQDFEHV 1762
+LE+ W+ + + E++ + E + + E+ Q F V
Sbjct: 3044 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 3103
Query: 1763 SVLQEKFSEFASETGM---AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAEL 1819
+L + S + + ++ Q VD + E H+ + + + + + E
Sbjct: 3104 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL----ENMTQKFKEF 3159
Query: 1820 LEL-MGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 1878
E+ ++ QL A +L D + G + L L T Q++L+
Sbjct: 3160 QEVSKESKRQLQCAKEQL-----DIHDSLGSQAYSNKYLTMLQT----------QQKSLQ 3204
Query: 1879 AFEHDLQLLVSQVRQLQEGAAQLR-TVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 1937
A +H + L + L A+ + T E IA + Q E S E
Sbjct: 3205 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3264
Query: 1938 VSSTADALRFHSQVRDLLSWMDGIASQIGA-ADKPRDVSSVEVLMNYHQGLKTELEARVP 1996
+ F + +R++ S ++ + A RD +++ + +LEA +
Sbjct: 3265 IG------HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMA 3318
Query: 1997 ELTTCQELGRSLLLNK-------------SAMADEIQAQLDKLGTRKEEVSEKWDRHWEW 2043
+ + +L + A++ + LD+ R+E+V R E+
Sbjct: 3319 SNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEF 3378
Query: 2044 LQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEER 2103
++ E Q+ A+E +G + + Q + + F+K
Sbjct: 3379 YSKLKEFSILLQK---------AEEHEESQGPVGMETETINQQLNMFKVFQK-------- 3421
Query: 2104 FSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPLARR 2163
E+I+ Q KQ LG+ L AA G E L+ + R
Sbjct: 3422 ----------EEIEPLQGKQQDVNWLGQ-------GLIQSAAKSTSTQGLEHDLDDVNAR 3464
Query: 2164 ASDTLSAEVRTRVGYVRQE-LKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPA 2222
TL+ +V R +++ L R Q ++ L + V+ L A + P
Sbjct: 3465 WK-TLNKKVAQRAAQLQEALLHCGRFQDALESL--LSWMVDTEELVANQK--------PP 3513
Query: 2223 AAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLT 2282
+AE + + QE ++L +R +R+ +V+ + + + + + + L+
Sbjct: 3514 SAEFKVVKAQIQE-----QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3568
Query: 2283 L--GRYEQMERRRERRERRLE 2301
L R+E + + E R R+LE
Sbjct: 3569 LLDSRWEALLNKAETRNRQLE 3589
Score = 61.2 bits (147), Expect = 1e-08
Identities = 331/1792 (18%), Positives = 673/1792 (37%), Gaps = 232/1792 (12%)
Query: 464 VEAAMKKHEAIEADIAAYEERVQGVAELAQALA-AEGYYDIRRVAAQR--DSVLRQWALL 520
++ +++ +A++ I++ + V+ + + A+ L A G + Q+ D ++ ++ L
Sbjct: 2174 LQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL 2233
Query: 521 TGLVGARRTRLEQNLALQKVFQE-MVYMVDWMEEMQAQLLSRECGQ---HLVEADDLLQK 576
+ V R +L+ L Q+ + M+DWM +++ L +E GQ + D++ K
Sbjct: 2234 SKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL--KEQGQVPLNSTALQDIISK 2291
Query: 577 HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARR 636
+ +LE DIA + + A+N +F ++ P + ++ + +E +
Sbjct: 2292 NIMLEQDIAGRQSSINAMNEKVKKF--METTDPSTASSLQAKMKDLSARFSEASHKHKET 2349
Query: 637 RAELEASRSLWALLQEL-EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTA 695
A++E ++ L + L E+ +++ K + L G T + ST+
Sbjct: 2350 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD------VPGKDVTELSQYMQESTS 2403
Query: 696 RLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRW 755
L K L+ + + L + LV E+ + +++
Sbjct: 2404 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVL------------------EKTNNLSKKF 2445
Query: 756 QRLEEAAARRERRLQEARA-LHQFGADLDGLLDWLRDAYRLA-------AAGDFGHDEAS 807
+ +E+ ++ + + L F + L W+++ + A D G
Sbjct: 2446 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2505
Query: 808 SRRLARQHRALTGEVEAHRGPVSGLRRQLATLG------GASGAGPLVVALQVRVVEAEQ 861
+++L + T E++ L ++ + A +G V+ + E+
Sbjct: 2506 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2565
Query: 862 LFA---------EVTEVAALRRQW---LRDALA--------VYRMFGEVHACELWIGEKE 901
+A ++T+++ L+D +A + + E A W+ +
Sbjct: 2566 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN 2625
Query: 902 QWLLSMRVPDSLDDVEVVQHRFE---SLDQEMNSLMGRVLDVNHTVQELVEGGH--PSSD 956
+ + + D E V+ + E S + E+ + +V ++ + EL+E P +
Sbjct: 2626 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2685
Query: 957 EVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRA 1016
+ ++S+W + +L R++++ N++ + V AQ+++ E
Sbjct: 2686 RWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQLKQWLVEKELMVSV 2742
Query: 1017 GGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGA------------- 1063
G L + L Q ++ LL+E A ++ Q QG
Sbjct: 2743 LGPLSIDPNMLNTQRQQVQ----ILLQEFATRKPQYE-QLTAAGQGILSRPGEDPSLRGI 2797
Query: 1064 --EELGA---EW----GALASAAQACGEAVAAAGRLQRFLHDLD---AFLDWLVRAQEAA 1111
E+L A +W G L+ +A+ + + Q L L + LD + + A
Sbjct: 2798 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2857
Query: 1112 GGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASE---ALLAADGAELGPGL 1168
+ LE A + K+E+ Q ++ A E AL+ + +
Sbjct: 2858 STHPDAMNQQLETAQKM-------KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2910
Query: 1169 ALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELP 1228
L+ L + K + + A +H +Q RD QA + + +E S +
Sbjct: 2911 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF-QAWLDTKKEEQNKSHP-IS 2968
Query: 1229 GTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQ 1288
++ +E +K H+DF T+ + + E LL + + A + ++ N
Sbjct: 2969 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 3028
Query: 1289 EN-QLRAQQWMQKLHDQLE-LQHFLRDCHELDGWIH------EKMLMARDGTREDN---- 1336
+ + ++ KL + LE + L WI E++ D +N
Sbjct: 3029 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 3088
Query: 1337 -HKLHKRWLRHQAFMAELAQN--KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
L K +H M EL N L E + + + E L V ++
Sbjct: 3089 LKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKF 3147
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGD-------LATVN 1446
LE+ TQ K ++ E SK E ++L + QL D G L +
Sbjct: 3148 CLENMTQ-KFKEFQEVSK---------ESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3197
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTA--------ALPLEPASKELVGERQNAVGERLV 1498
+Q K LQ+++ QV+ R +L + + L +E ++E Q V E+
Sbjct: 3198 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ-VDEKCS 3256
Query: 1499 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
L LQ +E+ + DDEL P+ E LQ ++ IK
Sbjct: 3257 FLETKLQGIGHFQNTIREMFSQFAEFDDEL---DSMAPVGRDAET---LQKQKETIKAFL 3310
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+ A + + A SP+ ++R LE L L + A+ R++ ++
Sbjct: 3311 KKLEALMASNDNANKTCKMMLATEE-TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVE 3369
Query: 1619 AAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL--QLLKKHLQLEQGVENYEE 1675
++E++Y + E L + E S+ E T+ QL + ++ +E +
Sbjct: 3370 GTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3429
Query: 1676 SIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY--Q 1731
++ + L++ S + +D + K L ++ +R A Q+ L+ +
Sbjct: 3430 KQQDVNWLGQGLIQSA-AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3488
Query: 1732 LSRQVSELEHWIAE-KEVVAGSPELGQDFEHV-------SVLQEKFSEFASETGMAGR-- 1781
+ L W+ + +E+VA +F+ V +LQ + S + R
Sbjct: 3489 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3548
Query: 1782 ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 1841
E++A + D+ ++ + + W+ LN+A +L G + +++ H+
Sbjct: 3549 EKIATTAEPADK-VKILKQLSLLDSRWEALLNKAETRNRQLEG----ISVVAQQFHETLE 3603
Query: 1842 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVRQLQEGA 1898
E IE+ RL AS ++ + +A E D+ + Q
Sbjct: 3604 PLNEWLTTIEK------RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3657
Query: 1899 AQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTA--DALRFHSQVRDLLS 1956
L+ + + E + + S+ + Q W + +R + A +A F +L++
Sbjct: 3658 QSLKVLSSREDKDMVQSK-LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3716
Query: 1957 WMDGIASQIGAADKPRDVSSVEVLMNYHQGL-KTELEARVPE---LTTCQELGRSLL--- 2009
W++ + ++ S + V +GL K + E RV + L Q + ++LL
Sbjct: 3717 WLNEVHDKL---------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGL 3767
Query: 2010 -LNKSAMADE---IQAQLDKLGTRKEEVSEKWDRHWEWLQQMLE----VHQFAQEAVVAD 2061
L K DE IQ +L+ + R +++++ + L+Q L+ +H +E
Sbjct: 3768 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC--- 3824
Query: 2062 AWLTAQEPLLQSRELG-SSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
WL E L S E +E Q R + +K A + SL +++
Sbjct: 3825 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3876
Score = 59.7 bits (143), Expect = 4e-08
Identities = 202/1022 (19%), Positives = 400/1022 (39%), Gaps = 160/1022 (15%)
Query: 1226 ELPGTVESVEEALKQHRDFLTTME---LSQ-QKMQVAVQAAEGLL-RQGNIYGEQAQEAV 1280
++ G V + +E L Q + +SQ Q + +A Q+A+ LL +QG + +E +
Sbjct: 1926 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1985
Query: 1281 TRLLEK---NQENQLRAQQWMQKLHDQL--ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+ +++ + E L + KL L EL+ F D E + W+ E+ L +
Sbjct: 1986 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 2045
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 1386
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 2046 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 2101
Query: 1387 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 1444
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 2102 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 2158
Query: 1445 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 1484
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 2159 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2218
Query: 1485 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 1542
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2219 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2277
Query: 1543 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 1601
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2278 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2337
Query: 1602 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 1652
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2338 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2394
Query: 1653 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 1693
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2395 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2454
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 1753
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2455 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2497
Query: 1754 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 1811
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2498 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2552
Query: 1812 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2553 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2612
Query: 1866 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 1899
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2613 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2672
Query: 1900 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 1956
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2673 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2731
Query: 1957 WM---DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
W+ + + S +G D + + Q L E R P+ G+ +L
Sbjct: 2732 WLVEKELMVSVLGPLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2789
Query: 2014 ---AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAV--VADAWLTAQE 2068
++ ++ QL + + + ++ + +W+ Q + Q + ++D
Sbjct: 2790 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2849
Query: 2069 PLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERF-------SSLRRLTTIEKIKAEQS 2121
L S + + D + Q + + ++ +++ L L E +KAE S
Sbjct: 2850 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS 2909
Query: 2122 KQ 2123
+Q
Sbjct: 2910 RQ 2911
Score = 53.9 bits (128), Expect = 2e-06
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 1686
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 786 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 845
Query: 1687 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 1746
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 846 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 896
Query: 1747 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 1806
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 897 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 955
Query: 1807 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 1859
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 956 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 1008
Score = 52.0 bits (123), Expect = 8e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 1372 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 1431
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 603 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 656
Query: 1432 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 1477
+ V G + T + + + + + G Q+ T +L
Sbjct: 657 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 716
Query: 1478 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 717 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 776
Query: 1521 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 777 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 836
Query: 1575 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 1633
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 837 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 889
Query: 1634 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 1693
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 890 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 949
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 1738
I E R A++ Q+ W+ QL + V +
Sbjct: 950 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 977
Score = 51.6 bits (122), Expect = 1e-05
Identities = 95/486 (19%), Positives = 202/486 (41%), Gaps = 66/486 (13%)
Query: 1215 LRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQV-AVQAAEGLLRQGNIYG 1273
+ ++E++ +L +++++ L +H D +T E ++ + QV +Q + LL ++
Sbjct: 1654 ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESL-- 1711
Query: 1274 EQAQEAVTRLLEKNQENQL--RAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDG 1331
+Q QE+ T K +E + R Q++ +KL +L + + L G H++ M DG
Sbjct: 1712 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL--LTQTENRLIG--HQEAFMIGDG 1767
Query: 1332 TRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 1385
T E +L K +AE+ +N E ++ G++L QE L + +KL
Sbjct: 1768 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL---IEQKL 1822
Query: 1386 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 1445
E + +L + ++L D++V + + + + + QL++ +
Sbjct: 1823 NEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE-----SKTKI 1871
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
+ L L +++ E + ++ Q E K +GE G LLE
Sbjct: 1872 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----LLET-- 1925
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
D+D ++ QE L Q + + + QH + +
Sbjct: 1926 -----------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH--------QAVI 1960
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVE 1624
+ +LE+ G S E E +++ +++L+ + L E+ ++ + ++E
Sbjct: 1961 IATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 2018
Query: 1625 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIAQLSRQ 1683
++ D E E WL + E + + + G D+ + L LK+ + V +++ + ++
Sbjct: 2019 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 2078
Query: 1684 CRALLE 1689
+LE
Sbjct: 2079 GNRVLE 2084
Score = 46.2 bits (108), Expect = 4e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 1429 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 1488
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 796 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 853
Query: 1489 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 1548
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 854 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 910
Query: 1549 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 1608
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 911 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 970
Query: 1609 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 1665
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 971 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 1030
Query: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 1696
++ + Y+ +IA L + + ++++ +S+
Sbjct: 1031 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 1061
Score = 43.5 bits (101), Expect = 0.003
Identities = 166/929 (17%), Positives = 350/929 (37%), Gaps = 144/929 (15%)
Query: 1231 VESVEEALKQHRD-------FLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283
+E + ++LK +RD ++ +E +Q+K+Q L + +
Sbjct: 1463 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1522
Query: 1284 LEKNQENQLRAQQWMQKLHDQLELQHF----LRDCHELDGWIHEKMLMARDGTREDNHKL 1339
K E Q A+Q+ + D ELQ + D + +M + D ++ L
Sbjct: 1523 QSKMDECQKYAEQYSATVKDY-ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1581
Query: 1340 HKRWLRHQAFMAELAQNK-EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 1398
R+ M + + + L+++E E + L +EK E ++ Q W S
Sbjct: 1582 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISK 1636
Query: 1399 TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQS 1454
T A + + + Q + S E+ K + LQ + GD T + + +L+
Sbjct: 1637 TLKDAEKAGKPPFSKQKISS-EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEK 1694
Query: 1455 MESQVEEWYR-----EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 1509
++E Y + +LQ + ++ K +V ERQ E+L + + L +
Sbjct: 1695 QVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTEN 1753
Query: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----I 1564
L+ +E + D EL Q + +Q + QA+ + +K + +E
Sbjct: 1754 RLIGHQEAFMIG-DGTVELKKYQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1811
Query: 1565 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS-----------AWAGLREAAERR 1613
Q +E+ L A + +AE ++ L+++ + A L E+ +
Sbjct: 1812 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKI 1871
Query: 1614 QQVLDAAFQVEQ-----------------YYFDVAEVEAWLGEQE-----LLMMSEDK-- 1649
+ +LD V++ +F + ++ +GE++ LL D
Sbjct: 1872 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQV 1931
Query: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQ 1704
G +++ Q +K + + + +++ ++ + LLE + + E++ + +
Sbjct: 1932 GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1991
Query: 1705 VDRLY-VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 1763
+ Y AL E ++ ++ Q L + +E EHW+ + E + E G D +
Sbjct: 1992 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 2051
Query: 1764 VLQEKFSEFASETGMAGRERLAAV----NQMVDELIECGH------TAAATMAEWKDGLN 1813
+ + K + SE ++ + L + N++++ C +AT E + L+
Sbjct: 2052 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 2111
Query: 1814 EAWAELLEL-------------------------MGTRAQLLAASRELHKFFS-----DA 1843
A L G A L A K S D
Sbjct: 2112 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 2171
Query: 1844 RELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT 1903
+ LQ Q+EE + ++ SS Q + + ++L+ L ++
Sbjct: 2172 KNLQRQLEETKALQGQI----------SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ- 2220
Query: 1904 VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIAS 1963
+ + I R +++ + E + +L ++ T +L + ++L WM + S
Sbjct: 2221 ----KTLDDIVGRYEDLSKSVNE-----RNEKLQITLTR-SLSVQDGLDEMLDWMGNVES 2270
Query: 1964 QIGAADK-PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLL-LNKSAMADEIQA 2021
+ + P + ++++ +++ + L+ ++ R + E + + + A +QA
Sbjct: 2271 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2330
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
++ L R E S K H E L +M E+
Sbjct: 2331 KMKDLSARFSEASHK---HKETLAKMEEL 2356
Score = 41.2 bits (95), Expect = 0.013
Identities = 120/590 (20%), Positives = 243/590 (41%), Gaps = 113/590 (19%)
Query: 1260 QAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRA--QQWMQKLHDQLELQHFLRDCHEL 1317
QAAE L++ +Y + E + +KN L + +QW ++ ++ ++ H L D +
Sbjct: 1360 QAAEALVK---LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1416
Query: 1318 DGWIHEKMLMAR-------DGTREDNHKLHKRWLRHQAFMAELAQNKE------------ 1358
I ++M D +E +L +RW + ++ E
Sbjct: 1417 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1476
Query: 1359 ------WLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKA 1412
W++++E +++ + +PE + ++ +L + + +E+E + SK
Sbjct: 1477 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKM 1526
Query: 1413 DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGEL 1469
D+ Q +AE + + +LQ + A V+SQ K K + M+S + +E +L
Sbjct: 1527 DE-CQKYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1581
Query: 1470 QAQTAALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLD 1525
+ + AL L+ + G+ L RL E +E++ + +KEL + ++
Sbjct: 1582 RTRYTAL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1635
Query: 1526 DELAWVQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGA 1580
L ++ + P + Q + ++ + + Q ++ + HG ++ EE E
Sbjct: 1636 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1695
Query: 1581 LASLRSPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYY 1627
+ +L+ L+QLQ + +E E+ Q + D Q E
Sbjct: 1696 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE--- 1752
Query: 1628 FDVAEVEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ES 1676
+G QE M+ + + K QS + L+K +Q L + V+N E E+
Sbjct: 1753 ------NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1806
Query: 1677 IAQLSRQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQY 1727
+LS++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q
Sbjct: 1807 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ- 1863
Query: 1728 WLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 1777
L + ++ L W++ V S G +H V+++ + F G
Sbjct: 1864 -LEESKTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1908
Score = 40.4 bits (93), Expect = 0.023
Identities = 66/340 (19%), Positives = 137/340 (40%), Gaps = 44/340 (12%)
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAAS--------RELHKFFSDARELQGQIEEKRRRLPR 1859
+ G+ + L+LM R LL +S E++ F ++L ++E + +L R
Sbjct: 745 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKF--VQDLLNWVDEMQVQLDR 802
Query: 1860 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQE 1919
T PS S + ++ S +++ + Q+ +AE + E +
Sbjct: 803 -TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQ 861
Query: 1920 VLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV 1979
+ +LL+ + H+ + + F S+ + L W++ + A D +++
Sbjct: 862 ----YAKLLNTSRNQERHLDTLHN---FVSRATNELIWLNEKEEEEVAYDWSERNTNIAR 914
Query: 1980 LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDR 2039
+YH L EL+ + + + QE+ LLL I+A + T+
Sbjct: 915 KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQ---------- 964
Query: 2040 HWEWLQQM---LEVH--------QFAQEAVVADAWLTAQEPLLQ---SRELGSSVDEVEQ 2085
W W+ Q+ +E H +F +A A +L + +Q S + SS+ ++E
Sbjct: 965 -WSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLED 1023
Query: 2086 LIRRHEAFRKAAAAWEERFSSLR-RLTTIEKIKAEQSKQP 2124
L++ ++ ++ ++L + TI ++K S P
Sbjct: 1024 LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP 1063
Score = 37.4 bits (85), Expect = 0.19
Identities = 34/177 (19%), Positives = 74/177 (41%), Gaps = 8/177 (4%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
+L + E + L ++ L+ L F + WLNE + + + +
Sbjct: 854 KLHRLESQYAKLLNTSRNQERHLDTL-HNFVSRATNELIWLNEKEE--EEVAYDWSERNT 910
Query: 465 EAAMKK--HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTG 522
A KK H + ++ EE ++ V E+A+ L E + + A R ++ QW+ +
Sbjct: 911 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 970
Query: 523 LVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQL---LSRECGQHLVEADDLLQK 576
L +++N A + F + D++ ++ + S + + + +DL+Q+
Sbjct: 971 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 1027
Score = 36.2 bits (82), Expect = 0.43
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 8/130 (6%)
Query: 1132 HAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEAR 1191
HA L E+DQ+EE+ + +E LL + L ++ + ++ W +L L +
Sbjct: 919 HAELMRELDQKEENIKSVQEIAEQLLLENHP---ARLTIEAYRAAMQTQWSWILQLCQCV 975
Query: 1192 REALVQAHIYQLFLRDLRQALVVLRNQEMALS---GAELPGTVESVEEALKQHRDFLTTM 1248
+ + + Y F D ++A LRN + A+ + ++ +E+ +++ +
Sbjct: 976 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME--EKE 1033
Query: 1249 ELSQQKMQVA 1258
EL Q K +A
Sbjct: 1034 ELLQYKSTIA 1043
Score = 32.3 bits (72), Expect = 6.2
Identities = 16/48 (33%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 531 LEQNLALQKVFQEMVY-MVDWMEEMQAQLLSRECGQHLVEADDLLQKH 577
L+QNL +++ + V +++W++EMQ QL E G L + L+ H
Sbjct: 772 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENH 819
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 293 bits (749), Expect = 2e-78
Identities = 190/466 (40%), Positives = 268/466 (57%), Gaps = 30/466 (6%)
Query: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116
DER+ VQKKTFTKW+N HL +V H+ DLY DLRDG L LLEVLSG+ LPR +GRMR
Sbjct: 31 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGRMR 89
Query: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176
H L+NV AL +LK ++V L N+ + DI DGN +LTLGL+WTIIL FQI I + E
Sbjct: 90 FHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGES- 148
Query: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236
E SAK+ LLLW Q T GY + +NFTT WRDG FNA+IH++RPDL+D + + +
Sbjct: 149 -EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQS 207
Query: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296
NL+ AF AE+ +G+ RLLDPEDV++ +PDEKS+ITYV S Y F K+ G+
Sbjct: 208 NLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPE---GGEG 263
Query: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356
IG +V K IE Y+ + L+ WI V +S + F N+ ++ + +
Sbjct: 264 IGANDVEV----KWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318
Query: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416
E P K EK ++ L ++ + +L +G DI+K WG+L A ERE A
Sbjct: 319 TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKA 375
Query: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
LR E+ R E L+ +A R R+S + E++ +++ + + +E+ ++ EA
Sbjct: 376 LRPEVERLEMLQQIANR-----VQRDSVICEDKLILAGNALQSDSKRLESGVQFQN--EA 428
Query: 477 DIAAY----EERVQGVAELAQALAAEGYYD----IRRVAAQRDSVL 514
+IA Y E ++ Q L YY ++RVA RD ++
Sbjct: 429 EIAGYILECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIM 474
Score = 142 bits (358), Expect = 4e-33
Identities = 396/1970 (20%), Positives = 766/1970 (38%), Gaps = 190/1970 (9%)
Query: 242 QRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVL 301
Q++ + + + LA+ L +D+ +EA D K ++ + L+ + L
Sbjct: 3022 QKSLQALKHQVDLAKRL-AQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFL 3080
Query: 302 DQVLE-VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKP 360
+ L+ +G E+ ++ + + + A +L ++ ++AF L+K
Sbjct: 3081 ETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAF-----LKK- 3134
Query: 361 VKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAE 420
LE L+ S + + C L + I + +LE + L
Sbjct: 3135 --------LEALMASNDNANKTCKMMLATEETSPDLVGIKR---DLEALSKQCNKLLDRA 3183
Query: 421 LIRQEKLELLAQRFDHKVAMRESWL----NENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476
R+E++E +R + + + + + SQ G E + + + +
Sbjct: 3184 QAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQK 3243
Query: 477 D-IAAYEERVQGVAELAQAL--AAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQ 533
+ I + + Q V L Q L +A + + D V +W L V R +L++
Sbjct: 3244 EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQE 3303
Query: 534 NLALQKVFQEMVY-MVDWM---EEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSE 589
L FQ+ + ++ WM EE+ A +V+A +Q+ LL+ + +
Sbjct: 3304 ALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQ--IQEQKLLQRLLDDRKS 3361
Query: 590 RVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWAL 649
VE + + + +P D I +++ + L +A R +LE +
Sbjct: 3362 TVEVIKREGEKIATTA--EPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQ 3419
Query: 650 LQE-LEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGEL 708
E LE W E+ L G S +AQHK L+ ++
Sbjct: 3420 FHETLEPLNEWLTTIEKRLVNCEPIGTQA--------------SKLEEQIAQHKALEDDI 3465
Query: 709 GGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQ-RLEEAAARRER 767
L QA+ G+ L + + + W ++E + R
Sbjct: 3466 INHNKHLHQAVSIGQSLKVLSSREDK--------DMVQSKLDFSQVWYIEIQEKSHSRSE 3517
Query: 768 RLQEARALHQ-FGADLDGLLDWLRDAY-RLAAAGDFGHDEASSRRLARQHRALTGEVEAH 825
LQ+A + FG D L++WL + + +L+ + + + R L ++
Sbjct: 3518 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3577
Query: 826 RGPV-SGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVY 884
+ V L L L +G L++ ++ ++A + ++T+++ + L AL +
Sbjct: 3578 KQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR--YKDITKLSTDVAKTLEQALQLA 3635
Query: 885 RMFGEVHACEL--WIGEKEQWLLSMRVPD-SLDDVEVVQHRFESLDQEM---NSLMGRVL 938
R H EL W+ + E LLS ++ Q R + L +E +L+ +
Sbjct: 3636 RRLHSTHE-ELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLN 3694
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE 998
+V+ + ELV E +D N R+ + + + Q+ EE+ A +L + A+
Sbjct: 3695 EVSSALLELVPWRAREGLEKMVAED--NERYRLVSDTITQKVEEIDAAILRSQQFDQAAD 3752
Query: 999 VR-AQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAA 1057
+ + E + + S G ++ A LQ + +L ++ + +
Sbjct: 3753 AELSWITETEKKLMSL----GDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHK 3808
Query: 1058 RLHQGAEE--------LGAEWGALASAAQACGEAVAAAGRLQ----RFLHDLDAFLDWLV 1105
+ +EE L + Q E R Q +F + WL
Sbjct: 3809 IMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLT 3868
Query: 1106 RAQEAAGGSEGPLPN-SLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAEL 1164
Q S+ P P E H L+E + + + ++ LL
Sbjct: 3869 ETQSII--SQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSP--- 3923
Query: 1165 GPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRD-LRQALVVL-RNQEMAL 1222
G G ++ E + + ++ + R AL +A D + Q L L R E
Sbjct: 3924 GEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLR 3983
Query: 1223 SGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQG-----NIYGEQAQ 1277
+ VE ++E + ++++ ME Q + Q E ++ + +I + Q
Sbjct: 3984 QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDKDISAKAVQ 4043
Query: 1278 EAVTRLLEKNQENQLRAQQWMQKLHDQLEL-QHFLRDCHELDGWIHEKMLMARDGTREDN 1336
+ + +++ + ++ KL D +EL + F D L I + RD ++
Sbjct: 4044 DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRD---LED 4100
Query: 1337 HKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS--------VRKKLGEI 1388
+ ++ Q AE +E ++ ++ E ++ EL A+ V+K + E+
Sbjct: 4101 PGIDPSVVKQQQEAAETI--REEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDEL 4158
Query: 1389 RQCWAELESTTQAKARQLFEASKA-----DQLVQSFAELDKKLLHMESQLQDVDP-GGDL 1442
W L + + +L EA +A D L F +D +L + P G DL
Sbjct: 4159 NSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVD----IAGGKLASMSPIGTDL 4214
Query: 1443 ATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-- 1500
TV Q+++L+ +S+ + E+ L Q A L L+ ++E ++ V + L+ L
Sbjct: 4215 ETVKQQIEELKQFKSEAYQQQIEMERLNHQ-AELLLKKVTEE---SDKHTVQDPLMELKL 4270
Query: 1501 -LEPLQER-----RRLLLASKELHQVAHDLDDELAWV--QERLPLAMQTERGNGLQAVQQ 1552
+ L+ER +L A L Q H LD+ LAW+ E L L+ Q G +A++
Sbjct: 4271 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGL-LSEQKPVGGDPKAIEI 4329
Query: 1553 HIKKNQGLRREIQAHGPRLEEVLERAG--ALASLRSPEAEAVRRGLEQLQSAWAGLREAA 1610
+ K+ L+ ++ AH +E V +AG + S EA ++ LE L W + E
Sbjct: 4330 ELAKHHVLQNDVLAHQSTVEAV-NKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKT 4388
Query: 1611 ERRQQVLDAAF-QVEQYYFDVAEVEAWLGEQEL-LMMSEDKGKDEQSTLQLLKKHLQLEQ 1668
E+R+Q LD A Q + ++ ++ +++ WL + E L+ S+ G ++ + L H+++
Sbjct: 4389 EQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4448
Query: 1669 GVENYEESIAQLSRQCRALLEMGHPDSE-QISRRQSQVDRLYVALKELGEERRVALEQQY 1727
E EE+ L ++ + +L +E I + + + + +++ ER+ LE+
Sbjct: 4449 AFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL 4508
Query: 1728 WL-YQLSRQVSELEHWIAEKEV---VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRER 1783
L + + + +W+ + E VA P L D + + K FA+E + RE+
Sbjct: 4509 NLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKV--FANEVN-SHREQ 4565
Query: 1784 LAAVNQMVDELIECGHTAAATMAE-WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSD 1842
+ +++ L + + + W ++++ + R + L +R+ K F +
Sbjct: 4566 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4625
Query: 1843 A-RELQGQIEEKRRRLP---RLTTPPEPRPSA----SSMQRTLRAFEHDLQLLVSQVRQL 1894
A +L +EE + L + P+ + Q++L A R L
Sbjct: 4626 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685
Query: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRD- 1953
+E +T A ++ + + E+ W + C + + +AL F Q D
Sbjct: 4686 KE-----KTSLADDNLK-LDDMLSELRDKWDTI---CGKSVERQNKLEEALLFSGQFTDA 4736
Query: 1954 ---LLSWMDGIASQIGAADKP--RDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSL 2008
L+ W+ + Q+ A D+P D+ V L++ H+ + EL R + + R L
Sbjct: 4737 LQALIDWLYRVEPQL-AEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSAREL 4795
Query: 2009 LLNKSAMADEIQAQLDKLGTRKEEVS----EKWDRHWEWLQQMLEVHQFAQEAVVADAWL 2064
+ + ++ Q+ +L TR E V K R L+Q E H + WL
Sbjct: 4796 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALL---EWL 4852
Query: 2065 TAQEPLLQSR-ELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTI 2113
E L+ L D + LI +H+ F K EE+ + L + TT+
Sbjct: 4853 AEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKL---EEKRAELNKATTM 4899
Score = 118 bits (295), Expect = 9e-26
Identities = 352/1865 (18%), Positives = 745/1865 (39%), Gaps = 139/1865 (7%)
Query: 295 KRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAY 354
K++ + Q+ E R+++ LL+W+ T L++NQK ++ V +
Sbjct: 3292 KKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVK-------- 3343
Query: 355 CTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHERE 414
+ QE+ L+ LL +S + R D K +L + E
Sbjct: 3344 ------AQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWE 3397
Query: 415 AALRAELIRQEKLE---LLAQRFDHKVAMRESWLNE-NQRLVSQDNFGYELPAVEAAMKK 470
A L R +LE ++AQ+F + WL +RLV+ + G + +E + +
Sbjct: 3398 ALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQ 3457
Query: 471 HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARRT 529
H+A+E DI + + + + Q+L + + + + + W + + +R
Sbjct: 3458 HKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSE 3517
Query: 530 RLEQNLALQKVF-QEMVYMVDWMEEMQAQLLSRECGQHLVEADDLLQKH-GLLEGDIAAQ 587
L+Q L K+F ++ V +++W+ E+ +L + E Q +L+ DI +
Sbjct: 3518 LLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLR 3577
Query: 588 SERVEA--LNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAE-LEASR 644
+ V+ LN L Q G + Q + + + +L A+ + L+ +R
Sbjct: 3578 KQNVDQALLNGLEL-LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLAR 3636
Query: 645 SLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKIL 704
L + +EL +W E L + G + +S A++ + K L
Sbjct: 3637 RLHSTHEELC---TWLDKVEVELLSYETQVLKG------------EEASQAQM--RPKEL 3679
Query: 705 QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAAR 764
+ E +ALL + L A+ GL + A R++ + + +
Sbjct: 3680 KKEAKNNKALL-------DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQ 3732
Query: 765 RERRLQEA-RALHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEV 822
+ + A QF D L W+ + + L + GD ++ + + + T E+
Sbjct: 3733 KVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEI 3792
Query: 823 EAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALA 882
H+ + L + + A +++ ++ + + + + ++ + R L A +
Sbjct: 3793 LRHKDIIDDLVKSGHKIMTACSEEEKQ-SMKKKLDKVLKNYDTICQINSERYLQLERAQS 3851
Query: 883 VYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGR----VL 938
+ F E + ELW E + ++P + E ++ + E +++ L+ +
Sbjct: 3852 LVNQFWETYE-ELWPWLTETQSIISQLPAPALEYETLRQQQEE-HRQLRELIAEHKPHID 3909
Query: 939 DVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRK----EEMSAVLLVENHVL 994
+N T +L+E ++ ++ +++I E V++R E +S + +
Sbjct: 3910 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3969
Query: 995 EVAEVRAQVREKRRAVESAPRAGGALQWRLS---GLEAALQALEPRQAALLEEAALLAER 1051
++ E ++ E+ R S ++ ++S + ++ L+P L + + R
Sbjct: 3970 QILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIAR 4029
Query: 1052 FPA-----QAARLHQGAEELGAEWGALASAAQACGEAVAAAGRL-QRFLHDLDAFLDWLV 1105
A + +++ W + + + + L ++F D + + +
Sbjct: 4030 SGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIK 4089
Query: 1106 RAQEAAGGSEGPLPNSLEEADALLARHAA--LKEEVDQREEDYARIVAASEALLAADGAE 1163
Q+ E P ++ + + AA ++EE+D +E+ ++ L+AA G
Sbjct: 4090 DTQDFIRDLEDP---GIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4146
Query: 1164 LGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQAL---VVLRNQEM 1220
P + + + L W L W+ R + L +A + +D QA+ V + ++
Sbjct: 4147 DKP--IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKL 4204
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLR----QGNIYGEQA 1276
A S + + +E+V++ +++ + F + Q +M+ AE LL+ + + + Q
Sbjct: 4205 A-SMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD 4263
Query: 1277 QEAVTRLLEKNQENQLRAQQWMQKLHDQL-ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+L+ + E ++ +Q KL L L F EL W+ E +L +
Sbjct: 4264 PLMELKLIWDSLEERIINRQ--HKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVG 4321
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCW 1392
D + +H ++ ++ +E + + G L++ E A++++ KL + Q W
Sbjct: 4322 GDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW 4381
Query: 1393 AELESTTQAKARQLFEASK-ADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT-----VN 1446
+ T+ + +QL A + A +L + L E L P G L +N
Sbjct: 4382 QNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLN 4441
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKEL-VGERQNAVGERLVRLLEPLQ 1505
++ + E++ EE Y+ + +Q L P S E + + N + E+ + L
Sbjct: 4442 VHMEVCAAFEAK-EETYKSL--MQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLN 4498
Query: 1506 ERRRLLLASKELHQVAHD-LDDELAWV-QERLPLAMQTERGNGLQAVQQHIKKNQGLRRE 1563
ER+ L + L H+ L D + W+ Q L + + L V I +++ E
Sbjct: 4499 ERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANE 4558
Query: 1564 IQAHGPRLEEVLERAGALASLRSPEAEAV--RRGLEQLQSAWAGL-REAAERRQQVLDAA 1620
+ +H ++ E L++ G S + + V + L +QS W + + ER + + DA
Sbjct: 4559 VNSHREQIIE-LDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4617
Query: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSE-DKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679
+ +Q++ +++ WL E E + SE + D L +H + ++ +
Sbjct: 4618 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4677
Query: 1680 LSRQCRALLEMGH--PDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLY-QLSRQV 1736
+R R+L E D+ ++ S++ + + ER+ LE+ Q + +
Sbjct: 4678 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4737
Query: 1737 SELEHWI--AEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL 1794
L W+ E ++ P G D + V L + F E G + A+ + EL
Sbjct: 4738 QALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKR-TSSVQALKRSAREL 4795
Query: 1795 IECGHTAAATMAEWKDGLNEAWAELLEL-MGTRAQLLAASRELHKFFSDARELQGQIEEK 1853
IE ++ + L+ W + L + + +L AA R+ +F S L + E
Sbjct: 4796 IEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEA 4855
Query: 1854 RRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAI 1913
+ L P+ + ++ + F ++ L + +L + TV A H ++I
Sbjct: 4856 EQTLRFHGVLPDDEDALRTLIDQHKEF---MKKLEEKRAELNKATTMGDTVLAICHPDSI 4912
Query: 1914 ASREQEVL---QGWKELLSACEDARLHVSSTADALRFHSQVRD-LLSWMDGIASQIGAAD 1969
+ + + ++E+L+ + + ++S L ++ + LL+W+ + + D
Sbjct: 4913 TTIKHWITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKD 4972
Query: 1970 K---PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDK- 2025
K P+++ V+ L+ HQ E+ + P++ + + + S++ I LDK
Sbjct: 4973 KEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPV-LDKG 5031
Query: 2026 -LGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVA---DAWLTAQEPLLQSRELGSSVD 2081
G ++ S + Q +E +V+ WL A E + R+L ++D
Sbjct: 5032 RAGRKRFPASSLYP---SGSQTQIETKNPRVNLLVSKWQQVWLLALE---RRRKLNDALD 5085
Query: 2082 EVEQL 2086
+E+L
Sbjct: 5086 RLEEL 5090
Score = 95.1 bits (235), Expect = 8e-19
Identities = 188/971 (19%), Positives = 367/971 (37%), Gaps = 77/971 (7%)
Query: 301 LDQVLEVGKIIERYEELAAELLAWIHRTVG-LISNQKFANSLSGVQQQLQAFTAYCTLEK 359
+D++ E + +Y++ + W+ G L S L V+QQ++ + K
Sbjct: 4173 IDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQF----K 4228
Query: 360 PVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRA 419
+Q++ +E L + L+ + ++ W LE+ R+ L
Sbjct: 4229 SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEG 4288
Query: 420 ELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDN-FGYELPAVEAAMKKHEAIEADI 478
L L +F H + +WL + L+S+ G + A+E + KH ++ D+
Sbjct: 4289 AL-------LALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDV 4341
Query: 479 AAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQ-WALLTGLVGARRTRLEQNLAL 537
A++ V+ V + L + + VL Q W + R+ +L+ L
Sbjct: 4342 LAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQ 4401
Query: 538 QKVFQ-EMVYMVDWMEEMQAQLL-SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALN 595
K F E+ + W+ + + LL S+ G A + L H + A+ E ++L
Sbjct: 4402 AKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLM 4461
Query: 596 AAALRFSQLQGYQPCDPQV-ICNRVNHVHGCLAELQEQAARRRAELEASRSL-WALLQEL 653
Q+ P + I +N++ ++ + R+ +LE + +L L
Sbjct: 4462 QKG---QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSL 4518
Query: 654 EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRA 713
++ +W E+ L A L + + +HK+ E+ R
Sbjct: 4519 QDFINWLTQAEQTLNVASRPSLI--------------LDTVLFQIDEHKVFANEVNSHRE 4564
Query: 714 LLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEAR 773
+ + + G L + +V + S + RW+++ + R R L +AR
Sbjct: 4565 QIIELDKTGTHLKYF-------SQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDAR 4617
Query: 774 A-LHQFGADLDGLLDWLRDAYR-LAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSG 831
QF L++WL ++ + L + + +D + QH+ + A
Sbjct: 4618 KRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDT 4677
Query: 832 LRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGE-V 890
R +L + + L + E + + + R+ L +AL F + +
Sbjct: 4678 TNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4737
Query: 891 HACELWIGEKEQWLLSMR-VPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVE 949
A W+ E L + V +D V + ++ +E+ V + + +EL+E
Sbjct: 4738 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIE 4797
Query: 950 GGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVL--LVENH--VLEVAEVRAQVRE 1005
G S V+ L++RW + L ++ + A L E H V + E A+ +
Sbjct: 4798 GSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQ 4857
Query: 1006 KRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAAL----LAERFPAQAARLHQ 1061
R P AL+ + + ++ LE ++A L + + LA P +
Sbjct: 4858 TLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4917
Query: 1062 GAEELGAEW-GALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGP-LP 1119
+ A + LA A Q +A L L+A L WL A+ + +P
Sbjct: 4918 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 4977
Query: 1120 NSLEEADALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLEL 1179
+EE AL+A H EE+ +++ D ++ + AAD + +L +P L+
Sbjct: 4978 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKR-RAADPS------SLQSHIPVLDK 5030
Query: 1180 GWHKLLGLWEARREALVQAHIY------QLFLRDLRQALVVLRNQEMALSGAELPGTVES 1233
G A R+ + +Y Q+ ++ R L+V + Q++ L E +
Sbjct: 5031 G--------RAGRKRFPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLND 5082
Query: 1234 VEEALKQHRDF 1244
+ L++ R+F
Sbjct: 5083 ALDRLEELREF 5093
Score = 63.9 bits (154), Expect = 2e-09
Identities = 225/1161 (19%), Positives = 451/1161 (38%), Gaps = 194/1161 (16%)
Query: 1221 ALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAV 1280
A++ + G V + E +F L+ K + + G G + ++ E
Sbjct: 2365 AIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMT-DISHGYEDLGLLLKDKIAELN 2423
Query: 1281 TRL--LEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338
T+L L+K QE QW+QK++ W + D
Sbjct: 2424 TKLSKLQKAQEESSAMMQWLQKMNKTATK------------W-------QQTPAPTDTEA 2464
Query: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK--LGEIRQCWAELE 1396
+ + ++++F AEL QN +++++ + +L++E P+ + R K L EI W EL
Sbjct: 2465 VKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELN 2524
Query: 1397 STTQAKARQLFEAS-KADQLVQSFAELDKKLLHMESQLQDVDP-GGDLATVNSQLKKLQS 1454
T + ++L E+S Q A+L + L+ E + + P D +N+Q +++Q
Sbjct: 2525 QLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQI 2584
Query: 1455 MESQVEEWYREVGELQAQTAA------LPLE-PASKELVGERQNAVGERLVRLLEPLQER 1507
+ ++E+ + + TAA P E P+ + +V E+ AV ++ L L +R
Sbjct: 2585 L---LQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDR 2641
Query: 1508 ----RRLLLASKELHQVAHDLDDELAWVQERL--PLAMQTERGNGLQAVQQHIKKNQGLR 1561
+ ++ S + + L D+L+ + +L LA+ T A+ Q ++ Q ++
Sbjct: 2642 CDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHP----DAMNQQLETAQKMK 2697
Query: 1562 REIQAHGPRL---EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+EIQ ++ + + E AL +AE + R LE + ++ + + AE Q L
Sbjct: 2698 QEIQQEKKQIKVAQALCEDLSALVKEEYLKAE-LSRQLEGILKSFKDVEQKAENHVQHLQ 2756
Query: 1619 AAFQVEQYYFDVA-EVEAWLGEQELLMMSEDKGKDEQSTLQ------LLKKHLQLEQGV- 1670
+A + ++ + +AWL ++ E++ K + + L+K H + +
Sbjct: 2757 SACASSHQFQQMSRDFQAWLDTKK-----EEQNKSHPISAKLDVLESLIKDHKDFSKTLT 2811
Query: 1671 ---ENYEESIAQ-----LSRQC--RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERR 1720
YE++IA+ L Q +A L++ Q++ ++ D +KE + +
Sbjct: 2812 AQSHMYEKTIAEGENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKERENKLK 2865
Query: 1721 VALEQQY-----------WLYQLSRQVSELEHWIAEKE-------VVAGSPELGQDFEHV 1762
+LE+ W+ + + E++ + E + + E+ Q F V
Sbjct: 2866 ESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMV 2925
Query: 1763 SVLQEKFSEFASETGM---AGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAEL 1819
+L + S + + ++ Q VD + E H+ + + + + + E
Sbjct: 2926 ELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL----ENMTQKFKEF 2981
Query: 1820 LEL-MGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLR 1878
E+ ++ QL A +L D + G + L L T Q++L+
Sbjct: 2982 QEVSKESKRQLQCAKEQL-----DIHDSLGSQAYSNKYLTMLQT----------QQKSLQ 3026
Query: 1879 AFEHDLQLLVSQVRQLQEGAAQLR-TVYAGEHAEAIASREQEVLQGWKELLSACEDARLH 1937
A +H + L + L A+ + T E IA + Q E S E
Sbjct: 3027 ALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQG 3086
Query: 1938 VSSTADALRFHSQVRDLLSWMDGIASQIGA-ADKPRDVSSVEVLMNYHQGLKTELEARVP 1996
+ F + +R++ S ++ + A RD +++ + +LEA +
Sbjct: 3087 IG------HFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMA 3140
Query: 1997 ELTTCQELGRSLLLNK-------------SAMADEIQAQLDKLGTRKEEVSEKWDRHWEW 2043
+ + +L + A++ + LD+ R+E+V R E+
Sbjct: 3141 SNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEF 3200
Query: 2044 LQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEER 2103
++ E Q+ A+E +G + + Q + + F+K
Sbjct: 3201 YSKLKEFSILLQK---------AEEHEESQGPVGMETETINQQLNMFKVFQK-------- 3243
Query: 2104 FSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLEPLARR 2163
E+I+ Q KQ LG+ L AA G E L+ + R
Sbjct: 3244 ----------EEIEPLQGKQQDVNWLGQ-------GLIQSAAKSTSTQGLEHDLDDVNAR 3286
Query: 2164 ASDTLSAEVRTRVGYVRQE-LKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPA 2222
TL+ +V R +++ L R Q ++ L + V+ L A + P
Sbjct: 3287 WK-TLNKKVAQRAAQLQEALLHCGRFQDALESL--LSWMVDTEELVANQK--------PP 3335
Query: 2223 AAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLT 2282
+AE + + QE ++L +R +R+ +V+ + + + + + + L+
Sbjct: 3336 SAEFKVVKAQIQE-----QKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLS 3390
Query: 2283 L--GRYEQMERRRERRERRLE 2301
L R+E + + E R R+LE
Sbjct: 3391 LLDSRWEALLNKAETRNRQLE 3411
Score = 61.2 bits (147), Expect = 1e-08
Identities = 331/1792 (18%), Positives = 673/1792 (37%), Gaps = 232/1792 (12%)
Query: 464 VEAAMKKHEAIEADIAAYEERVQGVAELAQALA-AEGYYDIRRVAAQR--DSVLRQWALL 520
++ +++ +A++ I++ + V+ + + A+ L A G + Q+ D ++ ++ L
Sbjct: 1996 LQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDL 2055
Query: 521 TGLVGARRTRLEQNLALQKVFQE-MVYMVDWMEEMQAQLLSRECGQ---HLVEADDLLQK 576
+ V R +L+ L Q+ + M+DWM +++ L +E GQ + D++ K
Sbjct: 2056 SKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSL--KEQGQVPLNSTALQDIISK 2113
Query: 577 HGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARR 636
+ +LE DIA + + A+N +F ++ P + ++ + +E +
Sbjct: 2114 NIMLEQDIAGRQSSINAMNEKVKKF--METTDPSTASSLQAKMKDLSARFSEASHKHKET 2171
Query: 637 RAELEASRSLWALLQEL-EEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSSTA 695
A++E ++ L + L E+ +++ K + L G T + ST+
Sbjct: 2172 LAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD------VPGKDVTELSQYMQESTS 2225
Query: 696 RLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRW 755
L K L+ + + L + LV E+ + +++
Sbjct: 2226 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVL------------------EKTNNLSKKF 2267
Query: 756 QRLEEAAARRERRLQEARA-LHQFGADLDGLLDWLRDAYRLA-------AAGDFGHDEAS 807
+ +E+ ++ + + L F + L W+++ + A D G
Sbjct: 2268 KEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLED 2327
Query: 808 SRRLARQHRALTGEVEAHRGPVSGLRRQLATLG------GASGAGPLVVALQVRVVEAEQ 861
+++L + T E++ L ++ + A +G V+ + E+
Sbjct: 2328 TKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEE 2387
Query: 862 LFA---------EVTEVAALRRQW---LRDALA--------VYRMFGEVHACELWIGEKE 901
+A ++T+++ L+D +A + + E A W+ +
Sbjct: 2388 FWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKMN 2447
Query: 902 QWLLSMRVPDSLDDVEVVQHRFE---SLDQEMNSLMGRVLDVNHTVQELVEGGH--PSSD 956
+ + + D E V+ + E S + E+ + +V ++ + EL+E P +
Sbjct: 2448 KTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAP 2507
Query: 957 EVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRA 1016
+ ++S+W + +L R++++ N++ + V AQ+++ E
Sbjct: 2508 RWKQMLTEIDSKWQELNQLTIDRQQKLEES---SNNLTQFQTVEAQLKQWLVEKELMVSV 2564
Query: 1017 GGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGA------------- 1063
G L + L Q ++ LL+E A ++ Q QG
Sbjct: 2565 LGPLSIDPNMLNTQRQQVQ----ILLQEFATRKPQYE-QLTAAGQGILSRPGEDPSLRGI 2619
Query: 1064 --EELGA---EW----GALASAAQACGEAVAAAGRLQRFLHDLD---AFLDWLVRAQEAA 1111
E+L A +W G L+ +A+ + + Q L L + LD + + A
Sbjct: 2620 VKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAV 2679
Query: 1112 GGSEGPLPNSLEEADALLARHAALKEEVDQREEDYARIVAASE---ALLAADGAELGPGL 1168
+ LE A + K+E+ Q ++ A E AL+ + +
Sbjct: 2680 STHPDAMNQQLETAQKM-------KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSR 2732
Query: 1169 ALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELP 1228
L+ L + K + + A +H +Q RD QA + + +E S +
Sbjct: 2733 QLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDF-QAWLDTKKEEQNKSHP-IS 2790
Query: 1229 GTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQ 1288
++ +E +K H+DF T+ + + E LL + + A + ++ N
Sbjct: 2791 AKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNW 2850
Query: 1289 EN-QLRAQQWMQKLHDQLE-LQHFLRDCHELDGWIH------EKMLMARDGTREDN---- 1336
+ + ++ KL + LE + L WI E++ D +N
Sbjct: 2851 DTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAK 2910
Query: 1337 -HKLHKRWLRHQAFMAELAQN--KEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWA 1393
L K +H M EL N L E + + + E L V ++
Sbjct: 2911 LKSLQKEMDQHFG-MVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKF 2969
Query: 1394 ELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGD-------LATVN 1446
LE+ TQ K ++ E SK E ++L + QL D G L +
Sbjct: 2970 CLENMTQ-KFKEFQEVSK---------ESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQ 3019
Query: 1447 SQLKKLQSMESQVEEWYREVGELQAQTA--------ALPLEPASKELVGERQNAVGERLV 1498
+Q K LQ+++ QV+ R +L + + L +E ++E Q V E+
Sbjct: 3020 TQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQ-VDEKCS 3078
Query: 1499 RLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558
L LQ +E+ + DDEL P+ E LQ ++ IK
Sbjct: 3079 FLETKLQGIGHFQNTIREMFSQFAEFDDEL---DSMAPVGRDAET---LQKQKETIKAFL 3132
Query: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618
+ A + + A SP+ ++R LE L L + A+ R++ ++
Sbjct: 3133 KKLEALMASNDNANKTCKMMLATEE-TSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVE 3191
Query: 1619 AAF-QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTL--QLLKKHLQLEQGVENYEE 1675
++E++Y + E L + E S+ E T+ QL + ++ +E +
Sbjct: 3192 GTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQG 3251
Query: 1676 SIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE--RRVALEQQYWLY--Q 1731
++ + L++ S + +D + K L ++ +R A Q+ L+ +
Sbjct: 3252 KQQDVNWLGQGLIQSA-AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGR 3310
Query: 1732 LSRQVSELEHWIAE-KEVVAGSPELGQDFEHV-------SVLQEKFSEFASETGMAGR-- 1781
+ L W+ + +E+VA +F+ V +LQ + S + R
Sbjct: 3311 FQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREG 3370
Query: 1782 ERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFS 1841
E++A + D+ ++ + + W+ LN+A +L G + +++ H+
Sbjct: 3371 EKIATTAEPADK-VKILKQLSLLDSRWEALLNKAETRNRQLEG----ISVVAQQFHETLE 3425
Query: 1842 DARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTL---RAFEHDLQLLVSQVRQLQEGA 1898
E IE+ RL AS ++ + +A E D+ + Q
Sbjct: 3426 PLNEWLTTIEK------RLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIG 3479
Query: 1899 AQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTA--DALRFHSQVRDLLS 1956
L+ + + E + + S+ + Q W + +R + A +A F +L++
Sbjct: 3480 QSLKVLSSREDKDMVQSK-LDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMN 3538
Query: 1957 WMDGIASQIGAADKPRDVSSVEVLMNYHQGL-KTELEARVPE---LTTCQELGRSLL--- 2009
W++ + ++ S + V +GL K + E RV + L Q + ++LL
Sbjct: 3539 WLNEVHDKL---------SKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGL 3589
Query: 2010 -LNKSAMADE---IQAQLDKLGTRKEEVSEKWDRHWEWLQQMLE----VHQFAQEAVVAD 2061
L K DE IQ +L+ + R +++++ + L+Q L+ +H +E
Sbjct: 3590 ELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELC--- 3646
Query: 2062 AWLTAQEPLLQSRELG-SSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTT 2112
WL E L S E +E Q R + +K A + SL +++
Sbjct: 3647 TWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSS 3698
Score = 59.7 bits (143), Expect = 4e-08
Identities = 202/1022 (19%), Positives = 400/1022 (39%), Gaps = 160/1022 (15%)
Query: 1226 ELPGTVESVEEALKQHRDFLTTME---LSQ-QKMQVAVQAAEGLL-RQGNIYGEQAQEAV 1280
++ G V + +E L Q + +SQ Q + +A Q+A+ LL +QG + +E +
Sbjct: 1748 DVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKL 1807
Query: 1281 TRLLEK---NQENQLRAQQWMQKLHDQL--ELQHFLRDCHELDGWIH--EKMLMARDGTR 1333
+ +++ + E L + KL L EL+ F D E + W+ E+ L +
Sbjct: 1808 QKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGA 1867
Query: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG------- 1386
+D + L + R ++F ++ +K L I G +++ E A S K+ G
Sbjct: 1868 DDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVL----EAAKSCSKRDGGKVDTSA 1923
Query: 1387 EIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDL--AT 1444
R+ +L+ T + R L+ SK + L + +L K H E + G AT
Sbjct: 1924 THREVQRKLDHATD-RFRSLY--SKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEAT 1980
Query: 1445 VNSQLKKL-----QSMESQVEEWYREVGELQAQTAALP---------------LEPASKE 1484
+ L + ++++ Q+EE G++ +Q A+ L PA +
Sbjct: 1981 ASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKND 2040
Query: 1485 LVGERQNAVGERLVRLLEPLQERR-RLLLASKELHQVAHDLDDELAWVQE-RLPLAMQTE 1542
+ + VG R L + + ER +L + V LD+ L W+ L Q +
Sbjct: 2041 IQKTLDDIVG-RYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQ 2099
Query: 1543 RGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPE-AEAVRRGLEQLQS 1601
A+Q I KN L ++I + + E+ P A +++ ++ L +
Sbjct: 2100 VPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSA 2159
Query: 1602 AWAGLREAAERRQQVL----DAAFQVEQYYFDVAEVEAWLGEQELLMMSED-KGKD---- 1652
++ EA+ + ++ L + +VE + +++ +L + + D GKD
Sbjct: 2160 RFS---EASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2216
Query: 1653 ----EQSTLQLL--KKHLQL---------EQGVENYE----ESIAQLSRQCRALLEMGHP 1693
++ST + L KKHL++ G+ + + E LS++ + + +
Sbjct: 2217 SQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKE 2276
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSP 1753
E ++ Q Q+D V +K L + W+ + +++V ++ G+
Sbjct: 2277 KKEAVTSCQEQLDAFQVLVKSL----------KSWIKETTKKVPIVQPSF-------GAE 2319
Query: 1754 ELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDG-- 1811
+LG+ E LQEK+S E ++ N LI T A +A K G
Sbjct: 2320 DLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCN-----LISAVTTPAKAIAAVKSGGA 2374
Query: 1812 -LN-EAWAELLELMGTRAQLLAASREL----HKFFSDARELQGQIEEKRRRLPRLTTPPE 1865
LN E A E L + +++ H + L+ +I E +L +L E
Sbjct: 2375 VLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQE 2434
Query: 1866 ----------------------PRPSASSMQRTL----RAFEHDLQLLVSQVRQLQEGAA 1899
P P+ + +T ++FE +L+ V++V++L++
Sbjct: 2435 ESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLT 2494
Query: 1900 QLRTVYAGEHAEAIASREQ--EVLQGWKELLSACEDARLHVSSTADAL-RFHSQVRDLLS 1956
+L + EA ++ E+ W+EL D + + +++ L +F + L
Sbjct: 2495 ELLEENP-DTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQ 2553
Query: 1957 WM---DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013
W+ + + S +G D + + Q L E R P+ G+ +L
Sbjct: 2554 WLVEKELMVSVLGPLS--IDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPG 2611
Query: 2014 ---AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAV--VADAWLTAQE 2068
++ ++ QL + + + ++ + +W+ Q + Q + ++D
Sbjct: 2612 EDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDN 2671
Query: 2069 PLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERF-------SSLRRLTTIEKIKAEQS 2121
L S + + D + Q + + ++ +++ L L E +KAE S
Sbjct: 2672 KLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELS 2731
Query: 2122 KQ 2123
+Q
Sbjct: 2732 RQ 2733
Score = 53.9 bits (128), Expect = 2e-06
Identities = 49/233 (21%), Positives = 110/233 (47%), Gaps = 13/233 (5%)
Query: 1630 VAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESI--AQLSR-QCRA 1686
V ++ W+ E ++ + + G D S L+ H + + +E +E S+ A++S Q A
Sbjct: 608 VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTA 667
Query: 1687 LLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEK 1746
L++ + +E++ R +SQ +L + +ER + + +SR +EL W+ EK
Sbjct: 668 PLKLTY--AEKLHRLESQYAKLLNTSRN--QERHLDTLHNF----VSRATNELI-WLNEK 718
Query: 1747 EVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMA 1806
E + + + +++ ++ +E E E + +V ++ ++L+ H A T+
Sbjct: 719 EEEEVAYDWSERNTNIARKKDYHAELMRELDQK-EENIKSVQEIAEQLLLENHPARLTIE 777
Query: 1807 EWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPR 1859
++ + W+ +L+L Q + + +FF+DA+E + + + R
Sbjct: 778 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQR 830
Score = 52.0 bits (123), Expect = 8e-06
Identities = 82/406 (20%), Positives = 156/406 (38%), Gaps = 70/406 (17%)
Query: 1372 QEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMES 1431
Q + E+A + + +RQ +++ K Q ADQLVQ A+L +++ + +
Sbjct: 425 QNEAEIAGYILECENLLRQHVIDVQILIDGKYYQ------ADQLVQRVAKLRDEIMALRN 478
Query: 1432 QLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREV-------GELQAQTAALP------- 1477
+ V G + T + + + + + G Q+ T +L
Sbjct: 479 ECSSVYSKGRILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSG 538
Query: 1478 ------------LEPA-----SKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520
+ PA LV + V ++ L+ +Q R+ LL +S +
Sbjct: 539 LSSGMTSRLTPSVTPAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNL 598
Query: 1521 AHD------LDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574
+ + D L WV E +TE G+ L +V+ H++ ++ + R I+ L+E
Sbjct: 599 TEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEA 658
Query: 1575 -LERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEV 1633
+ A L+ AE + R L+S +A L + +++ LD + +
Sbjct: 659 KISEIQMTAPLKLTYAEKLHR----LESQYAKLLNTSRNQERHLDT---LHNFVSRATNE 711
Query: 1634 EAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHP 1693
WL E+E ++ D + + + H +L + ++ EE+I + LL HP
Sbjct: 712 LIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHP 771
Query: 1694 DSEQISRRQSQVDRLYVALKELGEERRVALEQQY-WLYQLSRQVSE 1738
I E R A++ Q+ W+ QL + V +
Sbjct: 772 ARLTI------------------EAYRAAMQTQWSWILQLCQCVEQ 799
Score = 51.6 bits (122), Expect = 1e-05
Identities = 95/486 (19%), Positives = 202/486 (41%), Gaps = 66/486 (13%)
Query: 1215 LRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQV-AVQAAEGLLRQGNIYG 1273
+ ++E++ +L +++++ L +H D +T E ++ + QV +Q + LL ++
Sbjct: 1476 ISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESL-- 1533
Query: 1274 EQAQEAVTRLLEKNQENQL--RAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDG 1331
+Q QE+ T K +E + R Q++ +KL +L + + L G H++ M DG
Sbjct: 1534 KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDL--LTQTENRLIG--HQEAFMIGDG 1589
Query: 1332 TRE------DNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 1385
T E +L K +AE+ +N E ++ G++L QE L + +KL
Sbjct: 1590 TVELKKYQSKQEELQKDMQGSAQALAEVVKNTE--NFLKENGEKLSQEDKAL---IEQKL 1644
Query: 1386 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 1445
E + +L + ++L D++V + + + + + QL++ +
Sbjct: 1645 NEAKIKCEQLNLKAEQSKKEL------DKVVTTAIKEETEKVAAVKQLEE-----SKTKI 1693
Query: 1446 NSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQ 1505
+ L L +++ E + ++ Q E K +GE G LLE
Sbjct: 1694 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGN----LLET-- 1747
Query: 1506 ERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQ 1565
D+D ++ QE L Q + + + QH + +
Sbjct: 1748 -----------------DVDGQVGTTQENLNQQYQKVKAQHEKIISQH--------QAVI 1782
Query: 1566 AHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVE 1624
+ +LE+ G S E E +++ +++L+ + L E+ ++ + ++E
Sbjct: 1783 IATQSAQVLLEKQGQYLS--PEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELE 1840
Query: 1625 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQL-LKKHLQLEQGVENYEESIAQLSRQ 1683
++ D E E WL + E + + + G D+ + L LK+ + V +++ + ++
Sbjct: 1841 KFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITIS 1900
Query: 1684 CRALLE 1689
+LE
Sbjct: 1901 GNRVLE 1906
Score = 46.2 bits (108), Expect = 4e-04
Identities = 47/271 (17%), Positives = 113/271 (41%), Gaps = 8/271 (2%)
Query: 1429 MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGE 1488
M+ QL + G DL +V S L+ +++ +EE+ + E A+ + + + K E
Sbjct: 618 MQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKE--AKISEIQMTAPLKLTYAE 675
Query: 1489 RQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQ 1548
+ + + + +LL + + R L LH +EL W+ E+ + +
Sbjct: 676 KLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEEEVAYDWSERNT 732
Query: 1549 AVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLRE 1608
+ + + L RE+ ++ V E A L P + +Q+ W+ + +
Sbjct: 733 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 792
Query: 1609 AAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMM---SEDKGKDEQSTLQLLKKHLQ 1665
+ +Q + +++ D E +L + + S D+ L+++ ++
Sbjct: 793 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME 852
Query: 1666 LEQGVENYEESIAQLSRQCRALLEMGHPDSE 1696
++ + Y+ +IA L + + ++++ +S+
Sbjct: 853 EKEELLQYKSTIANLMGKAKTIIQLKPRNSD 883
Score = 43.5 bits (101), Expect = 0.003
Identities = 166/929 (17%), Positives = 350/929 (37%), Gaps = 144/929 (15%)
Query: 1231 VESVEEALKQHRD-------FLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRL 1283
+E + ++LK +RD ++ +E +Q+K+Q L + +
Sbjct: 1285 LEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK 1344
Query: 1284 LEKNQENQLRAQQWMQKLHDQLELQHF----LRDCHELDGWIHEKMLMARDGTREDNHKL 1339
K E Q A+Q+ + D ELQ + D + +M + D ++ L
Sbjct: 1345 QSKMDECQKYAEQYSATVKDY-ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1403
Query: 1340 HKRWLRHQAFMAELAQNK-EWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELEST 1398
R+ M + + + L+++E E + L +EK E ++ Q W S
Sbjct: 1404 RTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKEL-----QKWVSNISK 1458
Query: 1399 TQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVD----PGGDLATVNSQLKKLQS 1454
T A + + + Q + S E+ K + LQ + GD T + + +L+
Sbjct: 1459 TLKDAEKAGKPPFSKQKISS-EEISTKKEQLSEALQTIQLFLAKHGDKMT-DEERNELEK 1516
Query: 1455 MESQVEEWYR-----EVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRR 1509
++E Y + +LQ + ++ K +V ERQ E+L + + L +
Sbjct: 1517 QVKTLQESYNLLFSESLKQLQESQTSGDVKVEEK-IVAERQQEYKEKLQGICDLLTQTEN 1575
Query: 1510 LLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRRE-----I 1564
L+ +E + D EL Q + +Q + QA+ + +K + +E
Sbjct: 1576 RLIGHQEAFMIG-DGTVELKKYQSKQE-ELQKDMQGSAQALAEVVKNTENFLKENGEKLS 1633
Query: 1565 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS-----------AWAGLREAAERR 1613
Q +E+ L A + +AE ++ L+++ + A L E+ +
Sbjct: 1634 QEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKI 1693
Query: 1614 QQVLDAAFQVEQ-----------------YYFDVAEVEAWLGEQE-----LLMMSEDK-- 1649
+ +LD V++ +F + ++ +GE++ LL D
Sbjct: 1694 ENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQV 1753
Query: 1650 GKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE-----MGHPDSEQISRRQSQ 1704
G +++ Q +K + + + +++ ++ + LLE + + E++ + +
Sbjct: 1754 GTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKE 1813
Query: 1705 VDRLY-VALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVS 1763
+ Y AL E ++ ++ Q L + +E EHW+ + E + E G D +
Sbjct: 1814 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGL 1873
Query: 1764 VLQEKFSEFASETGMAGRERLAAV----NQMVDELIECGH------TAAATMAEWKDGLN 1813
+ + K + SE ++ + L + N++++ C +AT E + L+
Sbjct: 1874 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933
Query: 1814 EAWAELLEL-------------------------MGTRAQLLAASRELHKFFS-----DA 1843
A L G A L A K S D
Sbjct: 1934 HATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDP 1993
Query: 1844 RELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRT 1903
+ LQ Q+EE + ++ SS Q + + ++L+ L ++
Sbjct: 1994 KNLQRQLEETKALQGQI----------SSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQ- 2042
Query: 1904 VYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIAS 1963
+ + I R +++ + E + +L ++ T +L + ++L WM + S
Sbjct: 2043 ----KTLDDIVGRYEDLSKSVNE-----RNEKLQITLTR-SLSVQDGLDEMLDWMGNVES 2092
Query: 1964 QIGAADK-PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLL-LNKSAMADEIQA 2021
+ + P + ++++ +++ + L+ ++ R + E + + + A +QA
Sbjct: 2093 SLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQA 2152
Query: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEV 2050
++ L R E S K H E L +M E+
Sbjct: 2153 KMKDLSARFSEASHK---HKETLAKMEEL 2178
Score = 41.2 bits (95), Expect = 0.013
Identities = 120/590 (20%), Positives = 243/590 (41%), Gaps = 113/590 (19%)
Query: 1260 QAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRA--QQWMQKLHDQLELQHFLRDCHEL 1317
QAAE L++ +Y + E + +KN L + +QW ++ ++ ++ H L D +
Sbjct: 1182 QAAEALVK---LYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1238
Query: 1318 DGWIHEKMLMAR-------DGTREDNHKLHKRWLRHQAFMAELAQNKE------------ 1358
I ++M D +E +L +RW + ++ E
Sbjct: 1239 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1298
Query: 1359 ------WLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKA 1412
W++++E +++ + +PE + ++ +L + + +E+E + SK
Sbjct: 1299 YHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIE----------MKQSKM 1348
Query: 1413 DQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLK---KLQSMESQVEEWYREVGEL 1469
D+ Q +AE + + +LQ + A V+SQ K K + M+S + +E +L
Sbjct: 1349 DE-CQKYAEQYSATV-KDYELQTMT---YRAMVDSQQKSPVKRRRMQSSADLIIQEFMDL 1403
Query: 1470 QAQTAALPLEPASKELVGERQNAVGERLVRLLEP----LQERRRLLLASKELHQVAHDLD 1525
+ + AL L+ + G+ L RL E +E++ + +KEL + ++
Sbjct: 1404 RTRYTAL------VTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNIS 1457
Query: 1526 DELAWVQE--RLPLAMQTERGNGLQAVQQHIKKN-QGLRREIQAHGPRL--EEVLERAGA 1580
L ++ + P + Q + ++ + + Q ++ + HG ++ EE E
Sbjct: 1458 KTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQ 1517
Query: 1581 LASLRSPEAEAVRRGLEQLQSAWAG-------------LREAAERRQQVLDAAFQVEQYY 1627
+ +L+ L+QLQ + +E E+ Q + D Q E
Sbjct: 1518 VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTE--- 1574
Query: 1628 FDVAEVEAWLGEQELLMMSED--KGKDEQSTLQLLKKHLQ-----LEQGVENYE----ES 1676
+G QE M+ + + K QS + L+K +Q L + V+N E E+
Sbjct: 1575 ------NRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKEN 1628
Query: 1677 IAQLSRQCRALLEMGHPDS----EQISRRQSQVDR-----LYVALKELGEERRVALEQQY 1727
+LS++ +AL+E ++ EQ++ + Q + + A+KE E +VA +Q
Sbjct: 1629 GEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKE--ETEKVAAVKQ- 1685
Query: 1728 WLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETG 1777
L + ++ L W++ V S G +H V+++ + F G
Sbjct: 1686 -LEESKTKIENLLDWLS--NVDKDSERAGT--KHKQVIEQNGTHFQEGDG 1730
Score = 40.4 bits (93), Expect = 0.023
Identities = 66/340 (19%), Positives = 137/340 (40%), Gaps = 44/340 (12%)
Query: 1808 WKDGLNEAWAELLELMGTRAQLLAAS--------RELHKFFSDARELQGQIEEKRRRLPR 1859
+ G+ + L+LM R LL +S E++ F ++L ++E + +L R
Sbjct: 567 FSSGVEPNSLQTLKLMQIRKPLLKSSLLDQNLTEEEINMKF--VQDLLNWVDEMQVQLDR 624
Query: 1860 LTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQE 1919
T PS S + ++ S +++ + Q+ +AE + E +
Sbjct: 625 -TEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQ 683
Query: 1920 VLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV 1979
+ +LL+ + H+ + + F S+ + L W++ + A D +++
Sbjct: 684 ----YAKLLNTSRNQERHLDTLHN---FVSRATNELIWLNEKEEEEVAYDWSERNTNIAR 736
Query: 1980 LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDR 2039
+YH L EL+ + + + QE+ LLL I+A + T+
Sbjct: 737 KKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQ---------- 786
Query: 2040 HWEWLQQM---LEVH--------QFAQEAVVADAWLTAQEPLLQ---SRELGSSVDEVEQ 2085
W W+ Q+ +E H +F +A A +L + +Q S + SS+ ++E
Sbjct: 787 -WSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLED 845
Query: 2086 LIRRHEAFRKAAAAWEERFSSLR-RLTTIEKIKAEQSKQP 2124
L++ ++ ++ ++L + TI ++K S P
Sbjct: 846 LVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCP 885
Score = 37.4 bits (85), Expect = 0.19
Identities = 34/177 (19%), Positives = 74/177 (41%), Gaps = 8/177 (4%)
Query: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464
+L + E + L ++ L+ L F + WLNE + + + +
Sbjct: 676 KLHRLESQYAKLLNTSRNQERHLDTL-HNFVSRATNELIWLNEKEE--EEVAYDWSERNT 732
Query: 465 EAAMKK--HEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTG 522
A KK H + ++ EE ++ V E+A+ L E + + A R ++ QW+ +
Sbjct: 733 NIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQ 792
Query: 523 LVGARRTRLEQNLALQKVFQEMVYMVDWMEEMQAQL---LSRECGQHLVEADDLLQK 576
L +++N A + F + D++ ++ + S + + + +DL+Q+
Sbjct: 793 LCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQE 849
Score = 36.2 bits (82), Expect = 0.43
Identities = 29/130 (22%), Positives = 59/130 (45%), Gaps = 8/130 (6%)
Query: 1132 HAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEAR 1191
HA L E+DQ+EE+ + +E LL + L ++ + ++ W +L L +
Sbjct: 741 HAELMRELDQKEENIKSVQEIAEQLLLENHP---ARLTIEAYRAAMQTQWSWILQLCQCV 797
Query: 1192 REALVQAHIYQLFLRDLRQALVVLRNQEMALS---GAELPGTVESVEEALKQHRDFLTTM 1248
+ + + Y F D ++A LRN + A+ + ++ +E+ +++ +
Sbjct: 798 EQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESME--EKE 855
Query: 1249 ELSQQKMQVA 1258
EL Q K +A
Sbjct: 856 ELLQYKSTIA 865
Score = 32.3 bits (72), Expect = 6.2
Identities = 16/48 (33%), Positives = 28/48 (58%), Gaps = 1/48 (2%)
Query: 531 LEQNLALQKVFQEMVY-MVDWMEEMQAQLLSRECGQHLVEADDLLQKH 577
L+QNL +++ + V +++W++EMQ QL E G L + L+ H
Sbjct: 594 LDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENH 641
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,835,290
Number of Sequences: 37866
Number of extensions: 4705372
Number of successful extensions: 47097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 284
Number of HSP's successfully gapped in prelim test: 1432
Number of HSP's that attempted gapping in prelim test: 29996
Number of HSP's gapped (non-prelim): 11955
length of query: 2564
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2445
effective length of database: 13,741,464
effective search space: 33597879480
effective search space used: 33597879480
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.