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Search of human proteins with 224591416
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224591416 serine/threonine protein kinase pim-3 [Homo
sapiens]
(326 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224591416 serine/threonine protein kinase pim-3 [Homo sapiens] 665 0.0
gi|4505811 non-specific serine/threonine protein kinase [Homo sa... 437 e-123
gi|42821112 serine/threonine protein kinase pim-2 [Homo sapiens] 355 4e-98
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 149 4e-36
gi|35038528 PAS domain containing serine/threonine kinase [Homo ... 140 2e-33
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 137 1e-32
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 134 1e-31
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 132 4e-31
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 130 2e-30
gi|156105707 SNF related kinase [Homo sapiens] 129 4e-30
gi|156105705 SNF related kinase [Homo sapiens] 129 4e-30
gi|116256471 SNF1-like kinase [Homo sapiens] 129 4e-30
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 127 1e-29
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 127 1e-29
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 127 1e-29
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 127 1e-29
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 127 1e-29
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 127 1e-29
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 126 3e-29
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 123 2e-28
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 123 2e-28
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 123 3e-28
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 122 3e-28
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 120 1e-27
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 120 1e-27
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 120 1e-27
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 120 1e-27
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 120 1e-27
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens] 119 5e-27
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens] 119 5e-27
>gi|224591416 serine/threonine protein kinase pim-3 [Homo sapiens]
Length = 326
Score = 665 bits (1716), Expect = 0.0
Identities = 326/326 (100%), Positives = 326/326 (100%)
Query: 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI 60
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
Sbjct: 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI 60
Query: 61 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL 120
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
Sbjct: 61 ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL 120
Query: 121 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL 180
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
Sbjct: 121 LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL 180
Query: 181 RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC 240
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
Sbjct: 181 RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC 240
Query: 241 GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV 300
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
Sbjct: 241 GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV 300
Query: 301 PESCDLRLCTLDPDDVASTTSSSESL 326
PESCDLRLCTLDPDDVASTTSSSESL
Sbjct: 301 PESCDLRLCTLDPDDVASTTSSSESL 326
>gi|4505811 non-specific serine/threonine protein kinase [Homo
sapiens]
Length = 313
Score = 437 bits (1124), Expect = e-123
Identities = 219/315 (69%), Positives = 254/315 (80%), Gaps = 8/315 (2%)
Query: 1 MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI 60
MLLSK SLAHL D K L P K +KE E YQVG +LGSGGFG+VY+G R+
Sbjct: 1 MLLSKINSLAHLRAAPCNDLHATK-LAPGK-EKEPLESQYQVGPLLGSGGFGSVYSGIRV 58
Query: 61 ADGLPVAVKHVVKERVTEWGSL-GGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGF 119
+D LPVA+KHV K+R+++WG L G VP+EVVLL+KV + G GVIRLLDWFERPD F
Sbjct: 59 SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS--GFSGVIRLLDWFERPDSF 116
Query: 120 LLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVD 179
+L+LERPEP QDLFDFITERGAL E LAR FF QVL AVRHCH+CGV+HRDIKDEN+L+D
Sbjct: 117 VLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID 176
Query: 180 LRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMV 239
L GELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSA VWSLG+LLYDMV
Sbjct: 177 LNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236
Query: 240 CGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGG 299
CGDIPFE DEEI+RG++ FR+RVS ECQ LIRWCL+LRPS+RP+ ++I HPWM D
Sbjct: 237 CGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM--QDVL 294
Query: 300 VP-ESCDLRLCTLDP 313
+P E+ ++ L +L P
Sbjct: 295 LPQETAEIHLHSLSP 309
>gi|42821112 serine/threonine protein kinase pim-2 [Homo sapiens]
Length = 311
Score = 355 bits (910), Expect = 4e-98
Identities = 176/275 (64%), Positives = 206/275 (74%), Gaps = 1/275 (0%)
Query: 28 PAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGA-T 86
P D+E+FE Y++G +LG GGFGTV+AG R+ D L VA+K + + RV W L + T
Sbjct: 20 PGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVT 79
Query: 87 VPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPL 146
PLEV LL KVGA GG GVIRLLDWFE +GF+LVLERP PAQDLFD+ITE+G L E
Sbjct: 80 CPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGP 139
Query: 147 ARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDG 206
+R FF QV+AA++HCHS GVVHRDIKDEN+L+DLR G KLIDFGSGALL D YTDFDG
Sbjct: 140 SRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDG 199
Query: 207 TRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPEC 266
TRVYSPPEWI H+YH ATVWSLG+LLYDMVCGDIPFE+D+EIL L F VSP+C
Sbjct: 200 TRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDC 259
Query: 267 QQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVP 301
LIR CL+ +PS RPSL++I PWM VP
Sbjct: 260 CALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVP 294
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 149 bits (375), Expect = 4e-36
Identities = 94/283 (33%), Positives = 150/283 (53%), Gaps = 18/283 (6%)
Query: 20 HLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEW 79
HLP P + Y++ LG G G V G G VA+K V +E+++E
Sbjct: 16 HLPHP--HPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSES 73
Query: 80 GSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITER 139
+ V E+ +L+ + V++L D +E LVLE +LFD++ ++
Sbjct: 74 VLM---KVEREIAILKLIEHP----HVLKLHDVYENKKYLYLVLEHVS-GGELFDYLVKK 125
Query: 140 GALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGAL-LKD 198
G L AR+FF Q+++A+ CHS + HRD+K ENLL+D +++ DFG +L + D
Sbjct: 126 GRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNIRIADFGMASLQVGD 184
Query: 199 TVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEIL 252
++ G+ Y+ PE I+ +Y GR A +WS GV+L+ ++ G +PF+ D E++
Sbjct: 185 SLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVK 244
Query: 253 RGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLG 295
RG + P+CQ L+R + + P +R SL+QI HPW LG
Sbjct: 245 RGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLG 287
>gi|35038528 PAS domain containing serine/threonine kinase [Homo
sapiens]
Length = 1323
Score = 140 bits (353), Expect = 2e-33
Identities = 106/306 (34%), Positives = 151/306 (49%), Gaps = 23/306 (7%)
Query: 4 SKFGSLAHLCGPGGVDHL--------PVKI--LQPAKADKESFEKAYQVGAVLGSGGFGT 53
S + A L GP V+ L P K L+ A + + + Y + LGSG FG
Sbjct: 953 STHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGF 1012
Query: 54 VYAGSRIADGLPVAVKHVVKERVTE--W---GSLGGATVPLEVVLLRKVGAAGGARGVIR 108
V+ V VK + KE+V E W LG T LE+ +L +V A +I+
Sbjct: 1013 VWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVT--LEIAILSRVEHAN----IIK 1066
Query: 109 LLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVH 168
+LD FE F LV+E+ DLF FI LDEPLA F Q+++AV + ++H
Sbjct: 1067 VLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIH 1126
Query: 169 RDIKDENLLVDLRSGELKLIDFGSGALL-KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAT 227
RDIKDEN+++ +KLIDFGS A L + ++ F GT Y PE + + Y G
Sbjct: 1127 RDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELE 1185
Query: 228 VWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQI 287
+WSLGV LY +V + PF + EE + + VS E L+ L P R +L+++
Sbjct: 1186 MWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKL 1245
Query: 288 AAHPWM 293
PW+
Sbjct: 1246 VTDPWV 1251
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 137 bits (346), Expect = 1e-32
Identities = 94/299 (31%), Positives = 154/299 (51%), Gaps = 26/299 (8%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y++ LG G G V G VA+K V +E+++E + V E+ +L+ +
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLM---KVEREIAILKLIEH 75
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVR 159
V++L D +E LVLE + LFD++ ++G L AR+FF Q+++A+
Sbjct: 76 PH----VLKLHDVYENKKYLYLVLEHVSGGE-LFDYLVKKGRLTPKEARKFFRQIISALD 130
Query: 160 HCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRY 218
CHS + HRD+K ENLL+D +++ DFG +L + D++ G+ Y+ PE IR
Sbjct: 131 FCHSHSICHRDLKPENLLLD-EKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRG 189
Query: 219 HRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRW 272
+Y GR A VWS GV+L+ ++ G +PF+ D E++ RG + P+CQ L+R
Sbjct: 190 EKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRG 249
Query: 273 CLSLRPSERPSLDQIAAHPWMLGA------DGGVPESCDLR----LCTLDPDDVASTTS 321
+ + + R +L+ I H W +G + +P +R L +DPD + S S
Sbjct: 250 MIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHS 308
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 134 bits (337), Expect = 1e-31
Identities = 84/269 (31%), Positives = 141/269 (52%), Gaps = 18/269 (6%)
Query: 33 KESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVV 92
K + + Y++ LG G +G V + G VA+K + K+++ + + +E++
Sbjct: 48 KHNLKHRYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIM 107
Query: 93 LLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFA 152
++ +I + + FE D ++++E + L+D+I+ER L E R FF
Sbjct: 108 ------SSLNHPHIISIYEVFENKDKIVIIMEYASKGE-LYDYISERRRLSERETRHFFR 160
Query: 153 QVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYS 211
Q+++AV +CH GVVHRD+K EN+L+D + +K+ DFG S KD F G+ +Y+
Sbjct: 161 QIVSAVHYCHKNGVVHRDLKLENILLD-DNCNIKIADFGLSNLYQKDKFLQTFCGSPLYA 219
Query: 212 PPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDE------EILRGRLLFRRRVSP- 264
PE + Y G W+LGVLLY +V G +PF+ + +I G +R P
Sbjct: 220 SPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGE--YREPTQPS 277
Query: 265 ECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+ + LIRW L + P R +++ IA H W+
Sbjct: 278 DARGLIRWMLMVNPDRRATIEDIANHWWV 306
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 132 bits (332), Expect = 4e-31
Identities = 86/262 (32%), Positives = 134/262 (51%), Gaps = 16/262 (6%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y + LG G F V G VA+K + K ++ ++ + EV +++ +
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLD---AVNLEKIYREVQIMKMLDH 76
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVR 159
+I+L E LV E + + +FD++ G L+E ARR F Q+L+AV
Sbjct: 77 PH----IIKLYQVMETKSMLYLVTEYAKNGE-IFDYLANHGRLNESEARRKFWQILSAVD 131
Query: 160 HCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRY 218
+CH +VHRD+K ENLL+D + +K+ DFG G K + + G+ Y+ PE
Sbjct: 132 YCHGRKIVHRDLKAENLLLD-NNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEG 190
Query: 219 HRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRW 272
+Y G +WS+GV+LY +VCG +PF+ + +L GR +S +C+ LIR
Sbjct: 191 QQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRR 250
Query: 273 CLSLRPSERPSLDQIAAHPWML 294
L L PS+R ++ QI H WML
Sbjct: 251 MLVLDPSKRLTIAQIKEHKWML 272
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 130 bits (327), Expect = 2e-30
Identities = 88/267 (32%), Positives = 143/267 (53%), Gaps = 15/267 (5%)
Query: 33 KESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVV 92
K + Y+ LG G +G V +R + G VA+K + K+++ + L +E++
Sbjct: 46 KHNLRHRYEFLETLGKGTYGKVKK-ARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIM 104
Query: 93 LLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFA 152
++ +I + + FE ++V+E DL+D+I+ER L E AR FF
Sbjct: 105 ------SSLNHPHIIAIHEVFENSSKIVIVMEYASRG-DLYDYISERQQLSEREARHFFR 157
Query: 153 QVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTD-FDGTRVYS 211
Q+++AV +CH VVHRD+K EN+L+D +G +K+ DFG L + F G+ +Y+
Sbjct: 158 QIVSAVHYCHQNRVVHRDLKLENILLD-ANGNIKIADFGLSNLYHQGKFLQTFCGSPLYA 216
Query: 212 PPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFE-QDEEILRGRL---LFRRRVSP-EC 266
PE + Y G WSLGVLLY +V G +PF+ D +IL ++ +R P +
Sbjct: 217 SPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDA 276
Query: 267 QQLIRWCLSLRPSERPSLDQIAAHPWM 293
LIRW L + P+ R +L+ +A+H W+
Sbjct: 277 CGLIRWLLMVNPTRRATLEDVASHWWV 303
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 129 bits (324), Expect = 4e-30
Identities = 87/266 (32%), Positives = 133/266 (50%), Gaps = 16/266 (6%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y + LG G F V + G VAVK + K T+ +L + EV ++ V
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDK---TKLDTLATGHLFQEVRCMKLVQH 72
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLARRFFAQVLAAV 158
++RL + + L+LE + D+FD+I + L+E LA+++FAQ++ A+
Sbjct: 73 PN----IVRLYEVIDTQTKLYLILELGDGG-DMFDYIMKHEEGLNEDLAKKYFAQIVHAI 127
Query: 159 RHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 217
+CH VVHRD+K EN++ + G +KL DFG S T G+ YS PE +
Sbjct: 128 SYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILL 187
Query: 218 YHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEE------ILRGRLLFRRRVSPECQQLIR 271
Y + +WSLGV+L+ +VCG PF++ + I+ + VS EC+ LI
Sbjct: 188 GDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLIT 247
Query: 272 WCLSLRPSERPSLDQIAAHPWMLGAD 297
L P R SL++I HPW+ G D
Sbjct: 248 RMLQRDPKRRASLEEIENHPWLQGVD 273
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 129 bits (324), Expect = 4e-30
Identities = 87/266 (32%), Positives = 133/266 (50%), Gaps = 16/266 (6%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y + LG G F V + G VAVK + K T+ +L + EV ++ V
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDK---TKLDTLATGHLFQEVRCMKLVQH 72
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLARRFFAQVLAAV 158
++RL + + L+LE + D+FD+I + L+E LA+++FAQ++ A+
Sbjct: 73 PN----IVRLYEVIDTQTKLYLILELGDGG-DMFDYIMKHEEGLNEDLAKKYFAQIVHAI 127
Query: 159 RHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 217
+CH VVHRD+K EN++ + G +KL DFG S T G+ YS PE +
Sbjct: 128 SYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILL 187
Query: 218 YHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEE------ILRGRLLFRRRVSPECQQLIR 271
Y + +WSLGV+L+ +VCG PF++ + I+ + VS EC+ LI
Sbjct: 188 GDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLIT 247
Query: 272 WCLSLRPSERPSLDQIAAHPWMLGAD 297
L P R SL++I HPW+ G D
Sbjct: 248 RMLQRDPKRRASLEEIENHPWLQGVD 273
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 129 bits (324), Expect = 4e-30
Identities = 87/261 (33%), Positives = 131/261 (50%), Gaps = 16/261 (6%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y + LG G F V VA+K + K R+ S + EV L++ +
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLD---SSNLEKIYREVQLMKLLNH 83
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVR 159
+I+L E D +V E + + +FD++T G L E AR+ F Q+L+AV
Sbjct: 84 PH----IIKLYQVMETKDMLYIVTEFAKNGE-MFDYLTSNGHLSENEARKKFWQILSAVE 138
Query: 160 HCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRY 218
+CH +VHRD+K ENLL+D + ++KL DFG G K + + G+ Y+ PE
Sbjct: 139 YCHDHHIVHRDLKTENLLLD-GNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEG 197
Query: 219 HRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRW 272
Y G +WSLGV+LY +VCG +PF+ + +L GR +S +C+ LIR
Sbjct: 198 KEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRR 257
Query: 273 CLSLRPSERPSLDQIAAHPWM 293
L + P+ R ++ QI H WM
Sbjct: 258 MLVVDPARRITIAQIRQHRWM 278
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 127 bits (319), Expect = 1e-29
Identities = 87/270 (32%), Positives = 136/270 (50%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VAVK + K T+ S + E
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK---TQLNSSSLQKLFRE 100
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E LV+E + +FD++ G + E AR
Sbjct: 101 VRIMKVLNHPN----IVKLFEVIETEKTLYLVMEYASGGE-VFDYLVAHGRMKEKEARAK 155
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 156 FRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPP 214
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 215 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 274
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L PS+R +L+QI WM
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 127 bits (319), Expect = 1e-29
Identities = 87/270 (32%), Positives = 136/270 (50%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VAVK + K T+ S + E
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK---TQLNSSSLQKLFRE 100
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E LV+E + +FD++ G + E AR
Sbjct: 101 VRIMKVLNHPN----IVKLFEVIETEKTLYLVMEYASGGE-VFDYLVAHGRMKEKEARAK 155
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 156 FRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPP 214
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 215 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 274
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L PS+R +L+QI WM
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 127 bits (319), Expect = 1e-29
Identities = 87/270 (32%), Positives = 136/270 (50%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VAVK + K T+ S + E
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK---TQLNSSSLQKLFRE 100
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E LV+E + +FD++ G + E AR
Sbjct: 101 VRIMKVLNHPN----IVKLFEVIETEKTLYLVMEYASGGE-VFDYLVAHGRMKEKEARAK 155
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 156 FRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPP 214
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 215 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 274
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L PS+R +L+QI WM
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 127 bits (319), Expect = 1e-29
Identities = 87/270 (32%), Positives = 136/270 (50%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VAVK + K T+ S + E
Sbjct: 44 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK---TQLNSSSLQKLFRE 100
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E LV+E + +FD++ G + E AR
Sbjct: 101 VRIMKVLNHPN----IVKLFEVIETEKTLYLVMEYASGGE-VFDYLVAHGRMKEKEARAK 155
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 156 FRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPP 214
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 215 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 274
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L PS+R +L+QI WM
Sbjct: 275 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 127 bits (319), Expect = 1e-29
Identities = 87/270 (32%), Positives = 136/270 (50%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VAVK + K T+ S + E
Sbjct: 11 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDK---TQLNSSSLQKLFRE 67
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E LV+E + +FD++ G + E AR
Sbjct: 68 VRIMKVLNHPN----IVKLFEVIETEKTLYLVMEYASGGE-VFDYLVAHGRMKEKEARAK 122
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 123 FRQIVSAVQYCHQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPP 181
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 182 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 241
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L PS+R +L+QI WM
Sbjct: 242 TDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 127 bits (319), Expect = 1e-29
Identities = 86/269 (31%), Positives = 137/269 (50%), Gaps = 21/269 (7%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y++ +G G F V I G VA+K + K ++ SL L R+V
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNP-SSLQK--------LFREVRI 109
Query: 100 AGGAR--GVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAA 157
G +++L + E LV+E A ++FD++ G + E AR F Q+++A
Sbjct: 110 MKGLNHPNIVKLFEVIETEKTLYLVMEYAS-AGEVFDYLVSHGRMKEKEARAKFRQIVSA 168
Query: 158 VRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWI 216
V +CH +VHRD+K ENLL+D + +K+ DFG S + F G+ Y+ PE
Sbjct: 169 VHYCHQKNIVHRDLKAENLLLDAEA-NIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELF 227
Query: 217 RYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVSPECQQLI 270
+ +Y G +WSLGV+LY +V G +PF E E +LRG+ +S +C+ ++
Sbjct: 228 QGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESIL 287
Query: 271 RWCLSLRPSERPSLDQIAAHPWM-LGADG 298
R L L P++R +L+QI W+ +G +G
Sbjct: 288 RRFLVLNPAKRCTLEQIMKDKWINIGYEG 316
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 126 bits (316), Expect = 3e-29
Identities = 90/275 (32%), Positives = 140/275 (50%), Gaps = 25/275 (9%)
Query: 32 DKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVP--- 88
D + K Y++ +G+GGF V I G VA+K + K + G+ +P
Sbjct: 3 DYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL-------GSDLPRIK 55
Query: 89 LEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLAR 148
E+ L+ + + + +L E + +VLE P +LFD+I + L E R
Sbjct: 56 TEIEALKNLRH----QHICQLYHVLETANKIFMVLEYC-PGGELFDYIISQDRLSEEETR 110
Query: 149 RFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGAL---LKDTVYTDFD 205
F Q+++AV + HS G HRD+K ENLL D +LKLIDFG A KD
Sbjct: 111 VVFRQIVSAVAYVHSQGYAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQTCC 169
Query: 206 GTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLLFR 259
G+ Y+ PE I+ Y G A VWS+G+LLY ++CG +PF+ D ++I+RG+
Sbjct: 170 GSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVP 229
Query: 260 RRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWML 294
+ +SP L++ L + P +R S+ + HPW++
Sbjct: 230 KWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIM 264
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 123 bits (309), Expect = 2e-28
Identities = 83/261 (31%), Positives = 130/261 (49%), Gaps = 16/261 (6%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y++ +G G F V + G VAVK + K T+ + EV +++ +
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDK---TQLNPTSLQKLFREVRIMKILNH 116
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVR 159
+++L + E LV+E + +FD++ G + E AR F Q+++AV+
Sbjct: 117 PN----IVKLFEVIETEKTLYLVMEYASGGE-VFDYLVAHGRMKEKEARAKFRQIVSAVQ 171
Query: 160 HCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRY 218
+CH +VHRD+K ENLL+D +K+ DFG S F G+ Y+ PE +
Sbjct: 172 YCHQKYIVHRDLKAENLLLD-GDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQG 230
Query: 219 HRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVSPECQQLIRW 272
+Y G VWSLGV+LY +V G +PF E E +LRG+ +S +C+ L++
Sbjct: 231 KKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 290
Query: 273 CLSLRPSERPSLDQIAAHPWM 293
L L P +R SL+QI WM
Sbjct: 291 LLVLNPIKRGSLEQIMKDRWM 311
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 123 bits (309), Expect = 2e-28
Identities = 87/271 (32%), Positives = 142/271 (52%), Gaps = 21/271 (7%)
Query: 37 EKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRK 96
+K Y VG LG G + V + VAVK + +++ +P E+ +L
Sbjct: 9 KKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPT--DFVERFLPREMDILAT 66
Query: 97 VGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLA 156
V +I+ + FE DG + ++ DL +FI +GAL E +AR+ F Q+ +
Sbjct: 67 VNHGS----IIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSS 122
Query: 157 AVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDT-----VYTDFDGTRVY 210
AV++CH +VHRD+K ENLL+D + +KL DFG S L+D+ + F G+ Y
Sbjct: 123 AVKYCHDLDIVHRDLKCENLLLD-KDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAY 181
Query: 211 SPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDE--EILRGRLLFR------RRV 262
+ PE ++ Y + +WSLGV+LY MVCG +P++ + ++LR + R + +
Sbjct: 182 AAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNL 241
Query: 263 SPECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+ EC+ LI L S+R +D+I +H W+
Sbjct: 242 TCECKDLIYRMLQPDVSQRLHIDEILSHSWL 272
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 123 bits (308), Expect = 3e-28
Identities = 83/261 (31%), Positives = 126/261 (48%), Gaps = 16/261 (6%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y++ +G G F V + + VA+K + K ++ E + EV +++ +
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENL---KKIFREVQIMKMLCH 64
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVR 159
+IRL E LV E + +FD + G + E ARR F Q++ AV
Sbjct: 65 PH----IIRLYQVMETERMIYLVTEYASGGE-IFDHLVAHGRMAEKEARRKFKQIVTAVY 119
Query: 160 HCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRY 218
CH +VHRD+K ENLL+D +K+ DFG S + + G+ Y+ PE
Sbjct: 120 FCHCRNIVHRDLKAENLLLDANL-NIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEG 178
Query: 219 HRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRW 272
Y G +WSLGV+LY +VCG +PF+ +L G+ +S EC+ LIR
Sbjct: 179 KEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRH 238
Query: 273 CLSLRPSERPSLDQIAAHPWM 293
L L P++R S++QI H WM
Sbjct: 239 MLVLDPNKRLSMEQICKHKWM 259
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 122 bits (307), Expect = 3e-28
Identities = 80/260 (30%), Positives = 128/260 (49%), Gaps = 15/260 (5%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGA 99
Y +G LG G FG V G G VAVK + ++++ +G ++ + L +
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFR--- 83
Query: 100 AGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVR 159
+I+L P +V+E + LFD+I + G LDE +RR F Q+L+ V
Sbjct: 84 ---HPHIIKLYQVISTPSDIFMVMEYVSGGE-LFDYICKNGRLDEKESRRLFQQILSGVD 139
Query: 160 HCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 218
+CH VVHRD+K EN+L+D K+ DFG ++ D + G+ Y+ PE I
Sbjct: 140 YCHRHMVVHRDLKPENVLLDAHM-NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 198
Query: 219 HRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLLFRRRVSPECQQLIRW 272
Y G +WS GV+LY ++CG +PF+ D ++I G + ++P L++
Sbjct: 199 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 258
Query: 273 CLSLRPSERPSLDQIAAHPW 292
L + P +R ++ I H W
Sbjct: 259 MLQVDPMKRATIKDIREHEW 278
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 120 bits (302), Expect = 1e-27
Identities = 80/273 (29%), Positives = 139/273 (50%), Gaps = 36/273 (13%)
Query: 40 YQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGAT------VPLEVVL 93
YQ+G +G G + V VA+K + K +GG +P E+ +
Sbjct: 10 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDK--------MGGPEEFIQRFLPRELQI 61
Query: 94 LRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQ 153
+R + + +I++ + E DG + ++ D+FD + G L E A+ F Q
Sbjct: 62 VRTLDH----KNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQ 117
Query: 154 VLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDT---VYTDFDGTRVY 210
++ A+R+CH CGV HRD+K EN L L+ LKL DFG +L + + F G+ Y
Sbjct: 118 MVEAIRYCHGCGVAHRDLKCENAL--LQGFNLKLTDFGFAKVLPKSHRELSQTFCGSTAY 175
Query: 211 SPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRR--------- 261
+ PE ++ + + VWS+GV+LY M+C +PF+ D +I ++L++++
Sbjct: 176 AAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFD-DTDI--PKMLWQQQKGVSFPTHL 232
Query: 262 -VSPECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+S +CQ L++ L RPS+++++ HPW+
Sbjct: 233 SISADCQDLLKRLLEPDMILRPSIEEVSWHPWL 265
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 120 bits (302), Expect = 1e-27
Identities = 82/270 (30%), Positives = 134/270 (49%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VA+K + K T+ + E
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK---TQLNPTSLQKLFRE 103
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E L++E + +FD++ G + E AR
Sbjct: 104 VRIMKILNHPN----IVKLFEVIETEKTLYLIMEYASGGE-VFDYLVAHGRMKEKEARSK 158
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 159 FRQIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L P +R +L+QI W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 120 bits (302), Expect = 1e-27
Identities = 82/270 (30%), Positives = 134/270 (49%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VA+K + K T+ + E
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK---TQLNPTSLQKLFRE 103
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E L++E + +FD++ G + E AR
Sbjct: 104 VRIMKILNHPN----IVKLFEVIETEKTLYLIMEYASGGE-VFDYLVAHGRMKEKEARSK 158
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 159 FRQIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L P +R +L+QI W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 120 bits (302), Expect = 1e-27
Identities = 82/270 (30%), Positives = 134/270 (49%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VA+K + K T+ + E
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK---TQLNPTSLQKLFRE 103
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E L++E + +FD++ G + E AR
Sbjct: 104 VRIMKILNHPN----IVKLFEVIETEKTLYLIMEYASGGE-VFDYLVAHGRMKEKEARSK 158
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 159 FRQIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L P +R +L+QI W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 120 bits (302), Expect = 1e-27
Identities = 82/270 (30%), Positives = 134/270 (49%), Gaps = 16/270 (5%)
Query: 31 ADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLE 90
AD++ Y++ +G G F V I G VA+K + K T+ + E
Sbjct: 47 ADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDK---TQLNPTSLQKLFRE 103
Query: 91 VVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRF 150
V +++ + +++L + E L++E + +FD++ G + E AR
Sbjct: 104 VRIMKILNHPN----IVKLFEVIETEKTLYLIMEYASGGE-VFDYLVAHGRMKEKEARSK 158
Query: 151 FAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFG-SGALLKDTVYTDFDGTRV 209
F Q+++AV++CH +VHRD+K ENLL+D +K+ DFG S F G+
Sbjct: 159 FRQIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGGKLDTFCGSPP 217
Query: 210 YSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPF------EQDEEILRGRLLFRRRVS 263
Y+ PE + +Y G VWSLGV+LY +V G +PF E E +LRG+ +S
Sbjct: 218 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 277
Query: 264 PECQQLIRWCLSLRPSERPSLDQIAAHPWM 293
+C+ L++ L L P +R +L+QI W+
Sbjct: 278 TDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 119 bits (297), Expect = 5e-27
Identities = 91/303 (30%), Positives = 141/303 (46%), Gaps = 25/303 (8%)
Query: 15 PGGVDHLPVKILQPAKADKESFEKA-----YQVGAVLGSGGFGTVYAGSRIADGLPVAVK 69
P ++ P + L + ++ES ++ +++G LG G FG VY +A+K
Sbjct: 103 PSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALK 162
Query: 70 HVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGAR--GVIRLLDWFERPDGFLLVLERPE 127
+ K ++ + G +E L R+V R ++RL +F L+LE
Sbjct: 163 VLFKAQLEKAG--------VEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYA- 213
Query: 128 PAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKL 187
P ++ + + DE + ++ A+ +CHS V+HRDIK ENLL+ +GELK+
Sbjct: 214 PLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKI 272
Query: 188 IDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQ 247
DFG + T GT Y PPE I R H +WSLGVL Y+ + G PFE
Sbjct: 273 ADFGWSVHAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331
Query: 248 D------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVP 301
+ + I R F V+ + LI L PS+RP L ++ HPW + A+ P
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW-ITANSSKP 390
Query: 302 ESC 304
+C
Sbjct: 391 SNC 393
>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
Length = 403
Score = 119 bits (297), Expect = 5e-27
Identities = 91/303 (30%), Positives = 141/303 (46%), Gaps = 25/303 (8%)
Query: 15 PGGVDHLPVKILQPAKADKESFEKA-----YQVGAVLGSGGFGTVYAGSRIADGLPVAVK 69
P ++ P + L + ++ES ++ +++G LG G FG VY +A+K
Sbjct: 103 PSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALK 162
Query: 70 HVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGAR--GVIRLLDWFERPDGFLLVLERPE 127
+ K ++ + G +E L R+V R ++RL +F L+LE
Sbjct: 163 VLFKAQLEKAG--------VEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYA- 213
Query: 128 PAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKL 187
P ++ + + DE + ++ A+ +CHS V+HRDIK ENLL+ +GELK+
Sbjct: 214 PLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKI 272
Query: 188 IDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQ 247
DFG + T GT Y PPE I R H +WSLGVL Y+ + G PFE
Sbjct: 273 ADFGWSVHAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEA 331
Query: 248 D------EEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVP 301
+ + I R F V+ + LI L PS+RP L ++ HPW + A+ P
Sbjct: 332 NTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPW-ITANSSKP 390
Query: 302 ESC 304
+C
Sbjct: 391 SNC 393
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.141 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,877,794
Number of Sequences: 37866
Number of extensions: 664975
Number of successful extensions: 3037
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 476
Number of HSP's successfully gapped in prelim test: 271
Number of HSP's that attempted gapping in prelim test: 1323
Number of HSP's gapped (non-prelim): 940
length of query: 326
length of database: 18,247,518
effective HSP length: 103
effective length of query: 223
effective length of database: 14,347,320
effective search space: 3199452360
effective search space used: 3199452360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.