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Search of human proteins with 224548927
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224548927 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform a [Homo sapiens]
(675 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224548927 G-protein signaling modulator 1 (AGS3-like, C. eleg... 1365 0.0
gi|224548925 G-protein signaling modulator 1 (AGS3-like, C. eleg... 808 0.0
gi|164519122 LGN protein [Homo sapiens] 714 0.0
gi|224548929 G-protein signaling modulator 1 (AGS3-like, C. eleg... 343 2e-94
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 200 4e-51
gi|68299799 Purkinje cell protein 2 [Homo sapiens] 67 7e-11
gi|38045928 43 kD receptor-associated protein of the synapse iso... 59 1e-08
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 58 3e-08
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 58 3e-08
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 56 1e-07
gi|15619013 43 kD receptor-associated protein of the synapse iso... 55 2e-07
gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo sa... 54 4e-07
gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens] 54 4e-07
gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sap... 50 9e-06
gi|11545817 G-protein signaling modulator 3 (AGS3-like, C. elega... 49 1e-05
gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens] 49 2e-05
gi|22749211 transmembrane and tetratricopeptide repeat containin... 45 2e-04
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 45 3e-04
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 45 3e-04
gi|148612821 tetratricopeptide repeat domain 29 [Homo sapiens] 42 0.001
gi|29725607 smooth muscle cell associated protein-1 isoform 2 [H... 40 0.009
gi|89179321 smooth muscle cell associated protein-1 isoform 3 [H... 39 0.012
gi|83415184 transmembrane and tetratricopeptide repeat containin... 39 0.016
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 37 0.046
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 37 0.046
gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens] 37 0.078
gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens] 37 0.078
gi|41871960 kinesin-like 8 isoform b [Homo sapiens] 35 0.30
gi|41871955 kinesin-like 8 isoform a [Homo sapiens] 35 0.30
gi|41871946 kinesin-like 8 isoform a [Homo sapiens] 35 0.30
>gi|224548927 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform a [Homo sapiens]
Length = 675
Score = 1365 bits (3533), Expect = 0.0
Identities = 675/675 (100%), Positives = 675/675 (100%)
Query: 1 MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE
Sbjct: 1 MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60
Query: 61 DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120
DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG
Sbjct: 61 DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120
Query: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180
RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
Sbjct: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180
Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK
Sbjct: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300
EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT
Sbjct: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300
Query: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
Sbjct: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
Query: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLL 420
EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLL
Sbjct: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLL 420
Query: 421 RLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRV 480
RLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRV
Sbjct: 421 RLPLEREQNGDSHHSGDWRGPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRV 480
Query: 481 HVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP 540
HVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP
Sbjct: 481 HVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP 540
Query: 541 SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFF 600
SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFF
Sbjct: 541 SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFF 600
Query: 601 NMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGA 660
NMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGA
Sbjct: 601 NMLIKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGA 660
Query: 661 GGPPEPQQQCQPGAS 675
GGPPEPQQQCQPGAS
Sbjct: 661 GGPPEPQQQCQPGAS 675
>gi|224548925 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform b [Homo sapiens]
Length = 457
Score = 808 bits (2086), Expect = 0.0
Identities = 403/403 (100%), Positives = 403/403 (100%)
Query: 1 MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE
Sbjct: 1 MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTE 60
Query: 61 DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120
DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG
Sbjct: 61 DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLG 120
Query: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180
RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
Sbjct: 121 RFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD 180
Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK
Sbjct: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300
EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT
Sbjct: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYT 300
Query: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
Sbjct: 301 LLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
Query: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQG 403
EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQG
Sbjct: 361 EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQG 403
>gi|164519122 LGN protein [Homo sapiens]
Length = 684
Score = 714 bits (1844), Expect = 0.0
Identities = 379/639 (59%), Positives = 462/639 (72%), Gaps = 20/639 (3%)
Query: 23 RMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEH 82
RMEASCLELALEGERLCK+GD + GV+FFEAAVQVGTEDLKTLSAIYSQLGNAYFYL ++
Sbjct: 19 RMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDY 78
Query: 83 GRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDK 142
+ALEYH HDL LARTIGD++GEAKASGNLGNTLKVLG FDEA VCCQRHL I++E DK
Sbjct: 79 AKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDK 138
Query: 143 VGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKEL 202
VGEARALYN+GNVYHAKGK QD G P +VR+ L A +FYE NLSLV L
Sbjct: 139 VGEARALYNLGNVYHAKGKSFG---CPGPQDVGEFPEEVRDALQAAVDFYEENLSLVTAL 195
Query: 203 GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
GDRAAQGRA+GNLGNTHYLLGNF +A H++RL IAKEFGDKAAERRAYSNLGNA++FL
Sbjct: 196 GDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFL 255
Query: 263 GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQEL 322
G F+ A+EYYKKTL L+RQL+D+AVEAQ+CYSLGNTYTLLQDYE+A +YHL+HL IAQEL
Sbjct: 256 GEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQEL 315
Query: 323 ADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVL 382
DR+GEGRACWSLGNAY ++G QA+ FA+KHL+IS+E+GD+ GELTAR+N++ LQ+VL
Sbjct: 316 NDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVL 375
Query: 383 G---RLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWR 439
G + SE ++ G RPK +R S E +L++L E+ QN +S +
Sbjct: 376 GLSYSTNNSIMSENTEIDS-SLNGVRPKLGRRHSMENMELMKLTPEKVQNWNS----EIL 430
Query: 440 GPSRDSLPLPVRSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSD---EE 496
+ + P + ++ S L A + + R S+D +E
Sbjct: 431 AKQKPLIAKPSAKLLFVNRLKGKKYKTNSSTKVLQDASNSIDHRIPNSQRKISADTIGDE 490
Query: 497 CFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSM--TASPQTEEFFDL 554
FFDLL++FQS+RMDDQRC L + A T + T + + S SP T+EF DL
Sbjct: 491 GFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSSTPPKMMLKTSSVPVVSPNTDEFLDL 550
Query: 555 IASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGH---GEPQEPGDDFFNMLIKYQSSRI 611
+ASSQSRRLDDQRAS +LPGLR+T N+ + H + +E +DFF++L+K Q SR+
Sbjct: 551 LASSQSRRLDDQRASFSNLPGLRLT-QNSQSVLSHLMTNDNKEADEDFFDILVKCQGSRL 609
Query: 612 DDQRCPPPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRV 650
DDQRC PP +GPT+PDEDFFSLI R Q KRMDEQRV
Sbjct: 610 DDQRCAPPPATTKGPTVPDEDFFSLILRSQGKRMDEQRV 648
Score = 47.4 bits (111), Expect = 4e-05
Identities = 43/166 (25%), Positives = 68/166 (40%), Gaps = 29/166 (17%)
Query: 529 AAPTLEDRIAQPSMTASPQT---EEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGH 585
A+ +++ RI S T E FFDL++ QS R+DDQR + + + +
Sbjct: 467 ASNSIDHRIPNSQRKISADTIGDEGFFDLLSRFQSNRMDDQRCCLQEKNCHTASTTTSST 526
Query: 586 -----LRGHGEP--QEPGDDFFNMLIKYQSSRIDDQRCPPPDV----------------L 622
L+ P D+F ++L QS R+DDQR ++ +
Sbjct: 527 PPKMMLKTSSVPVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTQNSQSVLSHLM 586
Query: 623 PRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQ 668
DEDFF ++ + Q R+D+QR P GP P +
Sbjct: 587 TNDNKEADEDFFDILVKCQGSRLDDQR---CAPPPATTKGPTVPDE 629
Score = 30.0 bits (66), Expect = 7.3
Identities = 14/39 (35%), Positives = 21/39 (53%)
Query: 483 PRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQ 521
P + + P+ +E FF L+ + Q RMD+QR L Q
Sbjct: 616 PPPATTKGPTVPDEDFFSLILRSQGKRMDEQRVLLQRDQ 654
>gi|224548929 G-protein signaling modulator 1 (AGS3-like, C.
elegans) isoform c [Homo sapiens]
Length = 166
Score = 343 bits (881), Expect = 2e-94
Identities = 166/166 (100%), Positives = 166/166 (100%)
Query: 510 MDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRAS 569
MDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRAS
Sbjct: 1 MDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLIASSQSRRLDDQRAS 60
Query: 570 VGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMP 629
VGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMP
Sbjct: 61 VGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRCPPPDVLPRGPTMP 120
Query: 630 DEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS 675
DEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS
Sbjct: 121 DEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEPQQQCQPGAS 166
Score = 53.5 bits (127), Expect = 6e-07
Identities = 37/108 (34%), Positives = 50/108 (46%), Gaps = 33/108 (30%)
Query: 488 PRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQ 547
P+ P D FF++L K+QSSR+DDQRCP D PT+ D
Sbjct: 83 PQEPGDD---FFNMLIKYQSSRIDDQRCPPPD------VLPRGPTMPD------------ 121
Query: 548 TEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEP 595
E+FF LI Q++R+D+QR + G +G G P EP
Sbjct: 122 -EDFFSLIQRVQAKRMDEQRVDLA-----------GGPEQGAGGPPEP 157
Score = 37.4 bits (85), Expect = 0.046
Identities = 18/49 (36%), Positives = 25/49 (51%)
Query: 483 PRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAP 531
P +PR P+ +E FF L+ + Q+ RMD+QR L G A P
Sbjct: 109 PPDVLPRGPTMPDEDFFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEP 157
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 200 bits (508), Expect = 4e-51
Identities = 120/372 (32%), Positives = 204/372 (54%), Gaps = 21/372 (5%)
Query: 31 LALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHK 90
+++ G+ L AG V EAA+++GT LK +++S L +AY+ L ++ Y +
Sbjct: 199 VSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQ 258
Query: 91 HDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY 150
DL +A+T+GD+ GE +A GNLG+ G + EA + L +A + D+ + AL
Sbjct: 259 QDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALS 318
Query: 151 NIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEF------------------- 191
++G+VY A G NA + + L ++ L +A E
Sbjct: 319 SLGHVYTAIGDYP--NALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQC 376
Query: 192 YERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRA 251
+E++L + K+LG++ + RAY NLG+ ++ NF +A ++H L +A+E +KA E RA
Sbjct: 377 HEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQELMEKAIEMRA 436
Query: 252 YSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEY 311
Y+ LG+A + + A +Y+++ L ++ L+D+A E +A +LG + + DY+ A +
Sbjct: 437 YAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKL 496
Query: 312 HLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTA 371
H HL IAQEL+D +GRA ++GNAY ++G QA+ + ++ LQIS E+ DR + +
Sbjct: 497 HKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQAST 556
Query: 372 RMNVAQLQLVLG 383
N+A LG
Sbjct: 557 HGNLAVAYQALG 568
Score = 199 bits (505), Expect = 9e-51
Identities = 119/356 (33%), Positives = 193/356 (54%), Gaps = 19/356 (5%)
Query: 60 EDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVL 119
+D + S+ S LG+ Y + ++ AL HK +LLA+ D + EA+ GN+G +
Sbjct: 308 KDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAM 367
Query: 120 GRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK---GKQLSWN---------- 166
G F+ A C ++HL IA++ G+K EARA N+G+ YH + K +S++
Sbjct: 368 GDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLELAQEL 427
Query: 167 -----AANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYL 221
A GH +++ L +A +++E+ L + ++L DRAA+GRA NLG H +
Sbjct: 428 MEKAIEMRAYAGLGHAARCMQD-LERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQM 486
Query: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQ 281
G++ A HK L IA+E D AA+ RAY N+GNA+ LG +D A +Y+++ LQ+S +
Sbjct: 487 KGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISME 546
Query: 282 LRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVS 341
+ D+A +A +L Y L ++RA +++ HL IA+EL D E RA +LGN + S
Sbjct: 547 VNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCS 606
Query: 342 MGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLA 397
G QA + +++L+++ ++ D GE N+ LG + DLA
Sbjct: 607 RGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLA 662
Score = 175 bits (443), Expect = 1e-43
Identities = 102/348 (29%), Positives = 185/348 (53%), Gaps = 25/348 (7%)
Query: 30 ELALEGERLCKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALE 87
EL G GDF+ V E +++ + + + + YS LG+AY Y + +A+
Sbjct: 356 ELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMS 415
Query: 88 YHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEAR 147
YH + L LA+ + ++ E +A LG+ + + + A ++ L IA++ D+ E R
Sbjct: 416 YHNYVLELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGR 475
Query: 148 ALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAA 207
A N+G ++ KG + A + ++ +L + +EL D AA
Sbjct: 476 ASSNLGIIHQMKGDYDT-----------------------ALKLHKTHLCIAQELSDYAA 512
Query: 208 QGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDV 267
QGRAYGN+GN + LG + +A +H++ L I+ E D+A++ + NL A+ LG D
Sbjct: 513 QGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDR 572
Query: 268 AAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVG 327
A ++Y+ L ++R+LRD EA+A +LGN + +Y +AA Y+ ++L +A +L D G
Sbjct: 573 ALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEG 632
Query: 328 EGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNV 375
EG+ C +LG A+ +G +A+ + ++ L +++++ D+ + A N+
Sbjct: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNL 680
Score = 174 bits (441), Expect = 2e-43
Identities = 107/347 (30%), Positives = 179/347 (51%), Gaps = 25/347 (7%)
Query: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
GD+ T + + + + E D Y +GNAY L + +A++YH+ +L ++ +
Sbjct: 488 GDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEV 547
Query: 100 GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
DR +A GNL + LG D A Q HL+IA+E D EARAL N+GN + ++
Sbjct: 548 NDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSR 607
Query: 160 GKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTH 219
G+ + +A+ +YE+ L L +L D +G+ NLG H
Sbjct: 608 GEYV-----------------------QAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAH 644
Query: 220 YLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS 279
Y LGN+ EA ++++ LA+AK+ DK ++ +AY NLG A L F A E K L L+
Sbjct: 645 YCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLA 704
Query: 280 RQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAY 339
+ L + + +A +LG+ + +D A +++ + L +A ++ DR E A +LG AY
Sbjct: 705 QSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAY 764
Query: 340 VSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLT 386
+ + +AL + + L++ QE+ D GE A ++A + + LG+ T
Sbjct: 765 RMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYT 811
Score = 154 bits (388), Expect = 3e-37
Identities = 103/350 (29%), Positives = 181/350 (51%), Gaps = 25/350 (7%)
Query: 38 LCKAGDFKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLL 95
+CK D + F+E + + +D + ++ Y+ LG AY ++++ +AL YH +L +
Sbjct: 725 ICKK-DINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEV 783
Query: 96 ARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG-- 153
+ + D GE +A G+L LG++ A C + L + Q+ D EA+ N+G
Sbjct: 784 YQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGIT 843
Query: 154 ----NVYH----------AKGKQLSWNAA--NATQDPGHLPPDVRETLC---KASEFYER 194
NV A +QLS N + + + G+L D E L +A ++YE+
Sbjct: 844 KMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLG-DCYEALGDYEEAIKYYEQ 902
Query: 195 NLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSN 254
LS+ + L Q +AY LGN H +G+ +A ++RL +A E G+ + +AY
Sbjct: 903 YLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGE 962
Query: 255 LGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLR 314
LG+ H LG ++ A ++ L ++R ++D+A+E+ A LG Y + +Y+ A +YH
Sbjct: 963 LGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQL 1022
Query: 315 HLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGD 364
L IA+E + +GRA +LG Y S+G +A+ + ++HL I+ ++ D
Sbjct: 1023 DLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMND 1072
Score = 145 bits (367), Expect = 9e-35
Identities = 99/390 (25%), Positives = 180/390 (46%), Gaps = 68/390 (17%)
Query: 39 CKAGDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLA 96
C G++ ++E +++ + D++ + LG A++ L + A++Y++ DL LA
Sbjct: 605 CSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQDLALA 664
Query: 97 RTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
+ + D++ +AKA NLG K L F +A C + LS+AQ + + RAL N+G+++
Sbjct: 665 KDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLNNSQAKFRALGNLGDIF 724
Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
K + + A +FYE+ L L ++ DR + AY LG
Sbjct: 725 ICK-----------------------KDINGAIKFYEQQLGLAHQVKDRRLEASAYAALG 761
Query: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
+ ++ + +A +H + L + +E D E RA+ +L ++ LG++ +A + Y++ L
Sbjct: 762 TAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQL 821
Query: 277 QLSRQLRDQAVEAQ-------------------------------------------ACY 293
L ++L+D ++EAQ A
Sbjct: 822 DLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYG 881
Query: 294 SLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAK 353
+LG+ Y L DYE A +Y+ ++L +AQ L + +A LGN + +MG QAL +
Sbjct: 882 NLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFE 941
Query: 354 KHLQISQEIGDRHGELTARMNVAQLQLVLG 383
K L ++ E+G+ + A + L LG
Sbjct: 942 KRLVVAHELGEAFNKAQAYGELGSLHSQLG 971
Score = 130 bits (327), Expect = 4e-30
Identities = 85/336 (25%), Positives = 163/336 (48%), Gaps = 28/336 (8%)
Query: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
G + +E + +G + D + +Y +G + A+ Y + L + + +
Sbjct: 808 GKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAMLQQL 867
Query: 100 GDR---MGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
+ +A GNLG+ + LG ++EA +++LS+AQ +A+A +GN +
Sbjct: 868 SGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGH 927
Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
A G +L +A +E+ L + ELG+ + +AYG LG
Sbjct: 928 RAMG-----------------------SLQQALVCFEKRLVVAHELGEAFNKAQAYGELG 964
Query: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
+ H LGN+ +A + + +L IA++ D+A E A LG + +G +D A +Y++ L
Sbjct: 965 SLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDL 1024
Query: 277 QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLG 336
Q++ + + + +A +LG TY L +ERA Y +HL IA ++ D + + SLG
Sbjct: 1025 QIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLG 1084
Query: 337 NAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTAR 372
+ ++ +QA+ + ++ L++++++G R E R
Sbjct: 1085 RTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIR 1120
Score = 124 bits (310), Expect = 4e-28
Identities = 79/287 (27%), Positives = 137/287 (47%), Gaps = 30/287 (10%)
Query: 58 GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLK 117
G E + Y LG+ Y L ++ A++Y++ L +A+++ +AKA LGN +
Sbjct: 869 GNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHR 928
Query: 118 VLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHL 177
+G +A VC ++ L +A E G+ +A+A +G+++ G
Sbjct: 929 AMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYE-------------- 974
Query: 178 PPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLA 237
+A ER L++ +++ DRA + A LG + +G + A +H+ L
Sbjct: 975 ---------QAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQ 1025
Query: 238 IAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGN 297
IA+E + + RAY NLG + LG F+ A Y ++ L ++ Q+ D A + + SLG
Sbjct: 1026 IAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGR 1085
Query: 298 TYTLLQDYERAAEYHLRHLLIAQELADRVGE-------GRACWSLGN 337
T+ LQ+Y +A Y L +A++L R E G + W+ GN
Sbjct: 1086 THHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGN 1132
Score = 97.1 bits (240), Expect = 5e-20
Identities = 75/298 (25%), Positives = 141/298 (47%), Gaps = 27/298 (9%)
Query: 42 GDFKTGVAFFEAAVQVGTE--DLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTI 99
GD++ + ++E + V ++ + Y LGN + + +AL + L++A +
Sbjct: 891 GDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
Query: 100 GDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAK 159
G+ +A+A G LG+ LG +++A C +R L+IA++ D+ E+ A +G VY
Sbjct: 951 GEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQM 1010
Query: 160 GK--------QLSWNAANATQDP-------GHLPPDVRE--TLCKASEFYERNLSLVKEL 202
G+ QL A T +P G+L T +A + E++LS+ ++
Sbjct: 1011 GEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQM 1070
Query: 203 GDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFL 262
D AA+ +Y +LG TH+ L N+++A + +E L +A++ G + E + LG +
Sbjct: 1071 NDLAAKTVSYSSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWAS 1130
Query: 263 GRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTL-LQDYERAAEYHLRHLLIA 319
G + A + L +R +A L Y L L D + ++ L+ +L++
Sbjct: 1131 GNLEEAQHQLYRASALFETIRHEA-------QLSTDYKLSLFDLQTSSYQALQRVLVS 1181
Score = 50.1 bits (118), Expect = 7e-06
Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 7/105 (6%)
Query: 289 AQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQA 348
+ A +SLGNT E++ Y + L +A+ L D+ GE RA +LG+A+ S G +A
Sbjct: 241 SSAYWSLGNT-------EKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREA 293
Query: 349 LTFAKKHLQISQEIGDRHGELTARMNVAQLQLVLGRLTSPAASEK 393
LT + L ++ ++ DR +A ++ + +G + AS K
Sbjct: 294 LTNHRHQLVLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHK 338
>gi|68299799 Purkinje cell protein 2 [Homo sapiens]
Length = 136
Score = 66.6 bits (161), Expect = 7e-11
Identities = 40/114 (35%), Positives = 57/114 (50%), Gaps = 21/114 (18%)
Query: 490 APSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTE 549
A S D+E FF+LL+ Q RM+ QRC L G ++ + PT P+ +
Sbjct: 18 AGSPDQEGFFNLLSHVQGDRMEGQRCSLQAGPGQTTKSQSDPT-------------PEMD 64
Query: 550 EFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHG--------EPQEP 595
D++AS+Q RR+DDQR +V SLPG + S G + G PQ+P
Sbjct: 65 SLMDMLASTQGRRMDDQRVTVSSLPGFQPVGSKDGAQKRAGTLSPQPLLTPQDP 118
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/84 (29%), Positives = 38/84 (45%), Gaps = 8/84 (9%)
Query: 579 THSNAGHLRGHGEPQEPGDDFFNMLIKYQSSRIDDQRC-----PPPDVLPRGPTMPDED- 632
T +G G P + G FFN+L Q R++ QRC P + P+ D
Sbjct: 8 TEEGSGPCAEAGSPDQEG--FFNLLSHVQGDRMEGQRCSLQAGPGQTTKSQSDPTPEMDS 65
Query: 633 FFSLIQRVQAKRMDEQRVDLAGGP 656
++ Q +RMD+QRV ++ P
Sbjct: 66 LMDMLASTQGRRMDDQRVTVSSLP 89
Score = 32.7 bits (73), Expect = 1.1
Identities = 16/39 (41%), Positives = 22/39 (56%), Gaps = 1/39 (2%)
Query: 629 PDED-FFSLIQRVQAKRMDEQRVDLAGGPEQGAGGPPEP 666
PD++ FF+L+ VQ RM+ QR L GP Q +P
Sbjct: 21 PDQEGFFNLLSHVQGDRMEGQRCSLQAGPGQTTKSQSDP 59
>gi|38045928 43 kD receptor-associated protein of the synapse
isoform 2 [Homo sapiens]
Length = 353
Score = 58.9 bits (141), Expect = 1e-08
Identities = 47/180 (26%), Positives = 82/180 (45%), Gaps = 17/180 (9%)
Query: 196 LSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNL 255
+ +EL D +Y NL ++ L F + ++ K L + + ++
Sbjct: 70 IDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSM 129
Query: 256 GNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRH 315
GNA + L F A E ++K L+ + D +E + C SLG+ Y ++DYE+A + +
Sbjct: 130 GNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCK- 188
Query: 316 LLIAQELADRVGEGRACWSL----------GNAYVSMGRPAQALTFAKKHLQISQEIGDR 365
A EL + G+G WSL AY +GR A+ ++ ++I+ + GDR
Sbjct: 189 ---AAELVNNYGKG---WSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDR 242
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/193 (24%), Positives = 79/193 (40%), Gaps = 3/193 (1%)
Query: 198 LVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGN 257
++++ D + R G L H +G + E F ++ A+E D +Y NL
Sbjct: 32 VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLAR 91
Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLL 317
++ L F Y K L L + Q S+GN + L +++A E + L
Sbjct: 92 SNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALR 151
Query: 318 IAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHG---ELTARMN 374
A D + E R C SLG+ Y + +AL F K ++ G ++ +
Sbjct: 152 YAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYH 211
Query: 375 VAQLQLVLGRLTS 387
+A +LGRL S
Sbjct: 212 MAVAYRLLGRLGS 224
Score = 39.3 bits (90), Expect = 0.012
Identities = 27/122 (22%), Positives = 54/122 (44%), Gaps = 5/122 (4%)
Query: 44 FKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
F+ + FE A++ +D + LG+ Y +K++ +AL + L G
Sbjct: 139 FQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGK 198
Query: 102 RMG---EAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHA 158
A + ++ ++LGR A CC+ + IA + GD+ +A L +++ +
Sbjct: 199 GWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRS 258
Query: 159 KG 160
+G
Sbjct: 259 RG 260
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/343 (24%), Positives = 134/343 (39%), Gaps = 67/343 (19%)
Query: 65 LSAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTI--------------GDRMGEAK 107
L+ YS LGN Y KE G+ A+E+++H L L GD G +
Sbjct: 78 LAEAYSNLGNVY---KERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQ 134
Query: 108 A--------------SGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG 153
A +LGN LK LGR +EA C +L + Q + A A N+G
Sbjct: 135 AYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPN---FAVAWSNLG 188
Query: 154 NVYHAKGKQLSWNAAN-----ATQDPGHLPPDVR-ETLCKASEFYERNL-SLVKELGDRA 206
V++A+G+ W A + T DP L + + K + ++R + + ++ L
Sbjct: 189 CVFNAQGE--IWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSP 246
Query: 207 AQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFD 266
+GNL +Y G A ++ + + F D AY NL NA G
Sbjct: 247 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD------AYCNLANALKEKGSVA 300
Query: 267 VAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRV 326
A + Y L+L A + +L N + E A + + L + E A
Sbjct: 301 EAEDCYNTALRLC------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA--- 351
Query: 327 GEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
A +L + G+ +AL K+ ++IS D + +
Sbjct: 352 ---AAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
Score = 53.1 bits (126), Expect = 8e-07
Identities = 65/278 (23%), Positives = 106/278 (38%), Gaps = 57/278 (20%)
Query: 111 NLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG---------- 160
NLGN LK FD A R LS++ G N+ VY+ +G
Sbjct: 220 NLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG------NLACVYYEQGLIDLAIDTYR 273
Query: 161 ---------KQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRA 211
N ANA ++ G ++ +A + Y L L D +
Sbjct: 274 RAIELQPHFPDAYCNLANALKEKG--------SVAEAEDCYNTALRLCPTHAD------S 319
Query: 212 YGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEY 271
NL N GN EA +++ L + EF A+SNL + G+ A +
Sbjct: 320 LNNLANIKREQGNIEEAVRLYRKALEVFPEFA------AAHSNLASVLQQQGKLQEALMH 373
Query: 272 YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRA 331
YK+ +++S D A ++GNT +QD + A + + R + I AD A
Sbjct: 374 YKEAIRISPTFAD------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD------A 421
Query: 332 CWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
+L + + G +A+ + L++ + D + L
Sbjct: 422 HSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459
Score = 30.0 bits (66), Expect = 7.3
Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 20/175 (11%)
Query: 42 GDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
G+ + V + A++V E +A +S L + + AL ++K + ++ T D
Sbjct: 331 GNIEEAVRLYRKALEVFPE----FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD 386
Query: 102 RMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY-NIGNVYHA-- 158
A N+GNTLK + A C R + I D +++ + GN+ A
Sbjct: 387 ------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA 440
Query: 159 ---KGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGR 210
+L + +A + H + +C +++ ER LV + D+ + R
Sbjct: 441 SYRTALKLKPDFPDAYCNLAH----CLQIVCDWTDYDERMKKLVSIVADQLEKNR 491
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 57.8 bits (138), Expect = 3e-08
Identities = 84/343 (24%), Positives = 134/343 (39%), Gaps = 67/343 (19%)
Query: 65 LSAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTI--------------GDRMGEAK 107
L+ YS LGN Y KE G+ A+E+++H L L GD G +
Sbjct: 88 LAEAYSNLGNVY---KERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQ 144
Query: 108 A--------------SGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIG 153
A +LGN LK LGR +EA C +L + Q + A A N+G
Sbjct: 145 AYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPN---FAVAWSNLG 198
Query: 154 NVYHAKGKQLSWNAAN-----ATQDPGHLPPDVR-ETLCKASEFYERNL-SLVKELGDRA 206
V++A+G+ W A + T DP L + + K + ++R + + ++ L
Sbjct: 199 CVFNAQGE--IWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSP 256
Query: 207 AQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFD 266
+GNL +Y G A ++ + + F D AY NL NA G
Sbjct: 257 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD------AYCNLANALKEKGSVA 310
Query: 267 VAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRV 326
A + Y L+L A + +L N + E A + + L + E A
Sbjct: 311 EAEDCYNTALRLC------PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFA--- 361
Query: 327 GEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
A +L + G+ +AL K+ ++IS D + +
Sbjct: 362 ---AAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 401
Score = 53.1 bits (126), Expect = 8e-07
Identities = 65/278 (23%), Positives = 106/278 (38%), Gaps = 57/278 (20%)
Query: 111 NLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG---------- 160
NLGN LK FD A R LS++ G N+ VY+ +G
Sbjct: 230 NLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHG------NLACVYYEQGLIDLAIDTYR 283
Query: 161 ---------KQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRA 211
N ANA ++ G ++ +A + Y L L D +
Sbjct: 284 RAIELQPHFPDAYCNLANALKEKG--------SVAEAEDCYNTALRLCPTHAD------S 329
Query: 212 YGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEY 271
NL N GN EA +++ L + EF A+SNL + G+ A +
Sbjct: 330 LNNLANIKREQGNIEEAVRLYRKALEVFPEFA------AAHSNLASVLQQQGKLQEALMH 383
Query: 272 YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRA 331
YK+ +++S D A ++GNT +QD + A + + R + I AD A
Sbjct: 384 YKEAIRISPTFAD------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFAD------A 431
Query: 332 CWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
+L + + G +A+ + L++ + D + L
Sbjct: 432 HSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 469
Score = 30.0 bits (66), Expect = 7.3
Identities = 38/175 (21%), Positives = 72/175 (41%), Gaps = 20/175 (11%)
Query: 42 GDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
G+ + V + A++V E +A +S L + + AL ++K + ++ T D
Sbjct: 341 GNIEEAVRLYRKALEVFPE----FAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFAD 396
Query: 102 RMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALY-NIGNVYHA-- 158
A N+GNTLK + A C R + I D +++ + GN+ A
Sbjct: 397 ------AYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIA 450
Query: 159 ---KGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGR 210
+L + +A + H + +C +++ ER LV + D+ + R
Sbjct: 451 SYRTALKLKPDFPDAYCNLAH----CLQIVCDWTDYDERMKKLVSIVADQLEKNR 501
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 55.8 bits (133), Expect = 1e-07
Identities = 97/413 (23%), Positives = 161/413 (38%), Gaps = 77/413 (18%)
Query: 66 SAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRF 122
+A+ QLG L HGR ALE H +L L D +G A A +G L + +
Sbjct: 27 AALCHQLGEL---LAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDY 83
Query: 123 DEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY-----HAKGKQLSWNAANATQDPGHL 177
A ++L +A + RA IG + H +
Sbjct: 84 PAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQS----------------- 126
Query: 178 PPDVRETLCKASEFYERNLSLV-KELGDRAAQG-------RAYGNLGNTHYLLGNFTEAT 229
R+ L +A +E++L++V +EL AQG R Y NLG T L
Sbjct: 127 ----RDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCN 182
Query: 230 TFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEA 289
+ ++ + +A++ RA NLG H G+ A + + + +R + +E+
Sbjct: 183 DYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMES 242
Query: 290 QACYSLGNTYTLLQDY-------------------ERAAE-YHLRHLLIAQELADRV--G 327
+ C + L D+ +RAA +L+H+L L ++
Sbjct: 243 ECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEA 302
Query: 328 EGR-------ACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQL 380
EGR C LG+ + G +A +K L+ + E+ DR G A ++V+ L
Sbjct: 303 EGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFA-ELLDRPGAERAIIHVS-LAT 360
Query: 381 VLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSH 433
LG + + + YE + A+TW L + L RE+ GD++
Sbjct: 361 TLGDMKDHHGA----VRHYEEELRLRSGNVLEEAKTW--LNIALSREEAGDAY 407
Score = 35.0 bits (79), Expect = 0.23
Identities = 26/106 (24%), Positives = 46/106 (43%)
Query: 237 AIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLG 296
A A+ G + E LG GR+ A E + + LQL + D A A +G
Sbjct: 15 AKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIG 74
Query: 297 NTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSM 342
++DY A ++ ++L +A L + RA ++G ++ +
Sbjct: 75 ERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDI 120
>gi|15619013 43 kD receptor-associated protein of the synapse
isoform 1 [Homo sapiens]
Length = 412
Score = 55.5 bits (132), Expect = 2e-07
Identities = 55/225 (24%), Positives = 90/225 (40%), Gaps = 43/225 (19%)
Query: 196 LSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNL 255
+ +EL D +Y NL ++ L F + ++ K L + + ++
Sbjct: 70 IDTARELEDADFLLESYLNLARSNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSM 129
Query: 256 GNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLR- 314
GNA + L F A E ++K L+ + D +E + C SLG+ Y ++DYE+A + +
Sbjct: 130 GNAFLGLSVFQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKA 189
Query: 315 ---------------------HLLIAQELADRVGEGRACW--SLGNAYVSMGRPAQALT- 350
H+ +A L R+G C S+ A RP QAL
Sbjct: 190 AELVNNYGKGWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCL 249
Query: 351 --FAKKH----------------LQISQEIGDRHGELTARMNVAQ 377
FA H + I EIG+R G++ A + VA+
Sbjct: 250 LCFADIHRSRGDLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAK 294
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/193 (24%), Positives = 79/193 (40%), Gaps = 3/193 (1%)
Query: 198 LVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGN 257
++++ D + R G L H +G + E F ++ A+E D +Y NL
Sbjct: 32 VLEKSSDLMGRFRVLGCLVTAHSEMGRYKEMLKFAVVQIDTARELEDADFLLESYLNLAR 91
Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLL 317
++ L F Y K L L + Q S+GN + L +++A E + L
Sbjct: 92 SNEKLCEFHKTISYCKTCLGLPGTRAGAQLGGQVSLSMGNAFLGLSVFQKALESFEKALR 151
Query: 318 IAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHG---ELTARMN 374
A D + E R C SLG+ Y + +AL F K ++ G ++ +
Sbjct: 152 YAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGWSLKYRAMSQYH 211
Query: 375 VAQLQLVLGRLTS 387
+A +LGRL S
Sbjct: 212 MAVAYRLLGRLGS 224
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/186 (20%), Positives = 88/186 (47%), Gaps = 3/186 (1%)
Query: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDK- 245
KA E +E+ L D + R +LG+ + + ++ +A F + + +G
Sbjct: 141 KALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGKGW 200
Query: 246 AAERRAYS--NLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQ 303
+ + RA S ++ A+ LGR A E +++++++ Q D+ ++A + +
Sbjct: 201 SLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRG 260
Query: 304 DYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIG 363
D E A + + I E+ +R+G+ +A + +V+ +AL ++ +++E+G
Sbjct: 261 DLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKCWVARKALDKALDAIERAQDLAEEVG 320
Query: 364 DRHGEL 369
++ +L
Sbjct: 321 NKLSQL 326
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/290 (19%), Positives = 108/290 (37%), Gaps = 54/290 (18%)
Query: 44 FKTGVAFFEAAVQVG--TEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGD 101
F+ + FE A++ +D + LG+ Y +K++ +AL + L G
Sbjct: 139 FQKALESFEKALRYAHNNDDAMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNNYGK 198
Query: 102 RMG---EAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHA 158
A + ++ ++LGR A CC+ + IA + GD+ +A L +++ +
Sbjct: 199 GWSLKYRAMSQYHMAVAYRLLGRLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRS 258
Query: 159 KGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNT 218
+G L A Y+ +S++ E+G+R Q +A +
Sbjct: 259 RG-----------------------DLETAFPRYDSAMSIMTEIGNRLGQVQALLGVAKC 295
Query: 219 HYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
+A + +A+E G+K ++ + + +E ++ L
Sbjct: 296 WVARKALDKALDAIERAQDLAEEVGNKLSQLKLH--------------CLSESIYRSKGL 341
Query: 279 SRQLRDQAVEAQACY------------SLGNTYTLLQDYERAAEYHLRHL 316
R+LR V C S+G + LQ + +HLR L
Sbjct: 342 QRELRAHVVRFHECVEETELYCGLCGESIGEKNSRLQALPCSHIFHLRCL 391
>gi|145386551 SH3 domain and tetratricopeptide repeats 1 [Homo
sapiens]
Length = 1336
Score = 54.3 bits (129), Expect = 4e-07
Identities = 76/293 (25%), Positives = 115/293 (39%), Gaps = 31/293 (10%)
Query: 17 ARRLYSRME-ASC----LELALEGERLC-KAGDFKTGVAFFEAAVQVGTEDLKTLSAIYS 70
A RL+SR+ C + L+ LC + G + G ++E A+ V E S + +
Sbjct: 929 AVRLFSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRA 988
Query: 71 QLGNAYFY---LKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGR---FDE 124
+FY + + + YH+ L LA + D++ E + + LG +
Sbjct: 989 VQRLCHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKS 1048
Query: 125 AAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK--------QLSWNAANATQDP-- 174
A +R L I + K EA A G +Y+ + Q++ N A T DP
Sbjct: 1049 ALDYTKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNL 1108
Query: 175 --------GHLPPDVRETLCKASEFY-ERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNF 225
G + D KA FY +R L L G+R A+ R L L
Sbjct: 1109 GLELFEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEP 1168
Query: 226 TEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
E F LA++ GD+ ER AY L LG ++A +Y K L L
Sbjct: 1169 QEGLEFAHMALALSITLGDRLNERVAYHRLAALQHRLGHGELAEHFYLKALSL 1221
Score = 53.1 bits (126), Expect = 8e-07
Identities = 77/334 (23%), Positives = 128/334 (38%), Gaps = 66/334 (19%)
Query: 116 LKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNV-YHAKGKQLSWN-AANATQD 173
LK GR +AA R L +A++ G + +A L N G + HA +L+ + A +
Sbjct: 873 LKRTGRTRQAAESYYRALRVARDLGQQRNQAVGLANFGALCLHAGASRLAQHYLLEAVRL 932
Query: 174 PGHLP-----PDVRETLCKASE-------------FYERNLSLVKELGDRAAQGRAYGNL 215
LP D L + +YE L + E+G +Q RA L
Sbjct: 933 FSRLPLGECGRDFTHVLLQLGHLCTRQGPAQQGKGYYEWALLVAVEMGHVESQLRAVQRL 992
Query: 216 GNTHY-LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGR---FDVAAEY 271
+ + ++ + + +H+ +L++A + DK E + + ++ LG + A +Y
Sbjct: 993 CHFYSAVMPSEAQCVIYHELQLSLACKVADKVLEGQLLETISQLYLSLGTERAYKSALDY 1052
Query: 272 YKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQD--------------------------- 304
K++L + L+ + EA A G Y +L+
Sbjct: 1053 TKRSLGIFIDLQKKEKEAHAWLQAGKIYYILRQSELVDLYIQVAQNVALYTGDPNLGLEL 1112
Query: 305 YERAAE---------------YHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQAL 349
+E A + Y R L +A +R E R C L ++ P + L
Sbjct: 1113 FEAAGDIFFDGAWEREKAVSFYRDRALPLAVTTGNRKAELRLCNKLVALLATLEEPQEGL 1172
Query: 350 TFAKKHLQISQEIGDRHGELTARMNVAQLQLVLG 383
FA L +S +GDR E A +A LQ LG
Sbjct: 1173 EFAHMALALSITLGDRLNERVAYHRLAALQHRLG 1206
>gi|157785672 tetratricopeptide repeat domain 24 [Homo sapiens]
Length = 302
Score = 54.3 bits (129), Expect = 4e-07
Identities = 34/110 (30%), Positives = 51/110 (46%)
Query: 219 HYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
H LGN+ EA FH++ + G + + R++ +L A LG A + Y LQ
Sbjct: 3 HNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQA 62
Query: 279 SRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGE 328
+R D + QAC LG L Y++A +Y+ L Q+ D V E
Sbjct: 63 ARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112
Score = 53.9 bits (128), Expect = 5e-07
Identities = 47/176 (26%), Positives = 80/176 (45%), Gaps = 16/176 (9%)
Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLL 317
AH LG + A E+++K L + + + ++ SL + L D++ A + +L L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 318 IAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL-------T 370
A++ D G+ +AC LG A +G+ QAL + K+ L Q+ D E T
Sbjct: 62 AARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRERLVAKLADT 121
Query: 371 ARMNVAQLQLVL--------GRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWD 418
R +AQ+ LV GRL +P + + + +A G+ Q S+ W+
Sbjct: 122 VRTRLAQVGLVQTHTLTSAPGRLQAPGGASQAEGTPAKA-GSSTAGVQHRSSSGWE 176
Score = 53.1 bits (126), Expect = 8e-07
Identities = 32/102 (31%), Positives = 52/102 (50%)
Query: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKA 246
+A EF+++ L +G R QGR++G+L LG+ A + L A++ GD
Sbjct: 11 EAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQAARDSGDMK 70
Query: 247 AERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVE 288
+ +A LG A LG++D A +YYK+ L ++ D E
Sbjct: 71 GQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVRE 112
Score = 38.1 bits (87), Expect = 0.027
Identities = 24/77 (31%), Positives = 37/77 (48%)
Query: 69 YSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVC 128
+ L A L +H A + + H L AR GD G+ +A LG LG++D+A
Sbjct: 36 FGSLAFALSQLGDHKAARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKY 95
Query: 129 CQRHLSIAQEQGDKVGE 145
+ L+ Q++ D V E
Sbjct: 96 YKEALAQCQKEPDSVRE 112
Score = 32.3 bits (72), Expect = 1.5
Identities = 19/62 (30%), Positives = 29/62 (46%)
Query: 188 ASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAA 247
A + Y L ++ GD Q +A LG LG + +A ++KE LA ++ D
Sbjct: 52 ARDNYLHALQAARDSGDMKGQWQACEGLGAAAARLGQYDQALKYYKEALAQCQKEPDSVR 111
Query: 248 ER 249
ER
Sbjct: 112 ER 113
Score = 31.2 bits (69), Expect = 3.3
Identities = 21/79 (26%), Positives = 36/79 (45%)
Query: 75 AYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLS 134
A+ L + A E+H+ L ++G R + ++ G+L L LG A L
Sbjct: 2 AHNALGNYQEAREFHQKAADLHGSVGQRWEQGRSFGSLAFALSQLGDHKAARDNYLHALQ 61
Query: 135 IAQEQGDKVGEARALYNIG 153
A++ GD G+ +A +G
Sbjct: 62 AARDSGDMKGQWQACEGLG 80
>gi|38488692 SH3 domain and tetratricopeptide repeats 2 [Homo sapiens]
Length = 1288
Score = 49.7 bits (117), Expect = 9e-06
Identities = 80/349 (22%), Positives = 132/349 (37%), Gaps = 45/349 (12%)
Query: 17 ARRLYSRMEASCLELALE--------GERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAI 68
A RLY ++AS E +E + L G+ +E A+ G S +
Sbjct: 902 AVRLYCELQAS-KETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQL 960
Query: 69 YSQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLG------NTLKVL 119
+ +FY + YH+H L LA+ + DR E + +LG NT + L
Sbjct: 961 QATKSLCHFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSL 1020
Query: 120 GRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGK----QLSWNAANAT---- 171
R + C + L I + G+ A A G +++ + +L AA T
Sbjct: 1021 RR---SLTCIKESLRIFIDLGETDKAAEAWLGAGRLHYLMQEDELVELCLQAAIQTALKS 1077
Query: 172 ----------QDPGHLPPDVRETLCKASEFYERN-LSLVKELGDRAAQGRAYGNLGNTHY 220
++ G + + A E+Y + L + L + R + L
Sbjct: 1078 EEPLLALKLYEEAGDVFFNGTRHRHHAVEYYRAGAVPLARRLKAVRTELRIFNKLTELQI 1137
Query: 221 LLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLS- 279
L + +A F ++ GD+ E A+ L + L +++A + Y KTL L
Sbjct: 1138 SLEGYEKALEFATLAARLSTVTGDQRQELVAFHRLATVYYSLHMYEMAEDCYLKTLSLCP 1197
Query: 280 ---RQLRDQAVEAQACYSLGN-TYTLLQDYERAAEYHLRHLLIAQELAD 324
+ ++ A+ Y LG T+ L+D A EY L L A L D
Sbjct: 1198 PWLQSPKEALYYAKVYYRLGRLTFCQLKDAHDATEYFLLALAAAVLLGD 1246
Score = 47.0 bits (110), Expect = 6e-05
Identities = 53/210 (25%), Positives = 92/210 (43%), Gaps = 20/210 (9%)
Query: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKER---LAIAKEFG 243
+A++ Y R L+ +E+GD Q A NLG H L ++ + H R L + +
Sbjct: 854 RAAKSYLRALNRAQEVGDVHNQAVAMANLG--HLSLKSWAQ----HPARNYLLQAVRLYC 907
Query: 244 DKAAERRAYSNLGNAHVFLGRFDVAAEY-------YKKTLQLSRQLRDQAVEAQACYSLG 296
+ A + L ++L + V+ Y+ L + R + QA SL
Sbjct: 908 ELQASKETDMELVQVFLWLAQVLVSGHQLTHGLLCYEMALLFGLRHRHLKSQLQATKSLC 967
Query: 297 NTYTLLQ-DYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRP---AQALTFA 352
+ Y+ + + E YH L +AQ+L DR EGR SLG Y ++ ++LT
Sbjct: 968 HFYSSVSPNPEACITYHEHWLALAQQLRDREMEGRLLESLGQLYRNLNTARSLRRSLTCI 1027
Query: 353 KKHLQISQEIGDRHGELTARMNVAQLQLVL 382
K+ L+I ++G+ A + +L ++
Sbjct: 1028 KESLRIFIDLGETDKAAEAWLGAGRLHYLM 1057
Score = 43.1 bits (100), Expect = 8e-04
Identities = 84/364 (23%), Positives = 138/364 (37%), Gaps = 59/364 (16%)
Query: 50 FFEAAVQV---GTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLART------IG 100
+FE A+ + EDL ++ +Y L A YLK+ R HK LL + +
Sbjct: 550 YFEEAIHILNGAFEDLSLVATLYINL--AAIYLKQRLR----HKGSALLEKAGALLACLP 603
Query: 101 DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKG 160
DR AK D A ++ + + G EARA + + + G
Sbjct: 604 DRESSAKHE------------LDVVAYVLRQGIVV----GSSPLEARACFLAIRLLLSLG 647
Query: 161 K--QLSWNAANATQDPGHLPPDVRETLCKASEFYERN------LSLVKELGDRAAQGRAY 212
+ ++ A GH PP S Y++ ++ V++ G ++AQG +
Sbjct: 648 RHEEVLPFAERLQLLSGH-PPASEAVASVLSFLYDKKYLPHLAVASVQQHGIQSAQGMSL 706
Query: 213 GNLGNTHYLLGNFTEATTFH---------------KERLAIAKEFGDKAAERRAYSNLGN 257
+ H +L N T+ F ++ LA +E D++ +R L
Sbjct: 707 P-IWQVHLVLQNTTKLLGFPSPGWGEVSALACPMLRQALAACEELADRSTQRALCLILSK 765
Query: 258 AHVFLGRFDVAAEYYKKTLQLSRQLRDQ-AVEAQACYSLGNTYTLLQDYERAAEYHLRHL 316
++ D A Y + L L + L +Q + E+ C L Y L ++A + L
Sbjct: 766 VYLEHRSPDGAIHYLSQALVLGQLLGEQESFESSLC--LAWAYLLASQAKKALDVLEPLL 823
Query: 317 LIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVA 376
+E G LG A GR +A + L +QE+GD H + A N+
Sbjct: 824 CSLKETESLTQRGVIYNLLGLALQGEGRVNRAAKSYLRALNRAQEVGDVHNQAVAMANLG 883
Query: 377 QLQL 380
L L
Sbjct: 884 HLSL 887
>gi|11545817 G-protein signaling modulator 3 (AGS3-like, C. elegans)
[Homo sapiens]
Length = 160
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/107 (35%), Positives = 55/107 (51%), Gaps = 15/107 (14%)
Query: 545 SPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLR-GHGEPQEPGDDFFNML 603
S QTE DL+A +QSRRL++QRA+ T N L P E + ++ +
Sbjct: 59 SLQTELLLDLVAEAQSRRLEEQRATF-------YTPQNPSSLAPAPLRPLEDREQLYSTI 111
Query: 604 IKYQSSRIDDQRCPPPDVLPRGPTMPDEDFFSLIQRVQ-AKRMDEQR 649
+ +Q R++ QR PP LP G ++ L+ RVQ RM+EQR
Sbjct: 112 LSHQCQRMEAQRSEPP--LPPG----GQELLELLLRVQGGGRMEEQR 152
Score = 34.3 bits (77), Expect = 0.39
Identities = 33/130 (25%), Positives = 53/130 (40%), Gaps = 34/130 (26%)
Query: 492 SSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATA-APTLEDRIAQPSMTASPQTEE 550
S E DL+ + QS R+++QR Q ++ A A LEDR E+
Sbjct: 59 SLQTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLEDR------------EQ 106
Query: 551 FFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQ-SS 609
+ I S Q +R++ QR+ PG G + +L++ Q
Sbjct: 107 LYSTILSHQCQRMEAQRSEPPLPPG--------------------GQELLELLLRVQGGG 146
Query: 610 RIDDQRCPPP 619
R+++QR PP
Sbjct: 147 RMEEQRSRPP 156
>gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens]
Length = 672
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/174 (22%), Positives = 68/174 (39%), Gaps = 43/174 (24%)
Query: 209 GRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVA 268
G Y +GN LG A H++ L IAKE+ A+ RA N+G +G+F A
Sbjct: 320 GNLYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQA 379
Query: 269 AEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGE 328
+ +++ + L++ E+ +H
Sbjct: 380 IDTWEEKIPLAK----------------------TTLEKTWLFH---------------- 401
Query: 329 GRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGELTARMNVAQLQLVL 382
+G Y+ + + QA + +K Q ++E GD +L A + VAQ Q+ L
Sbjct: 402 -----EIGRCYLELDQAWQAQNYGEKSQQCAEEEGDIEWQLNASVLVAQAQVKL 450
Score = 38.9 bits (89), Expect = 0.016
Identities = 42/192 (21%), Positives = 77/192 (40%), Gaps = 26/192 (13%)
Query: 68 IYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAV 127
+YS +GNA L + AL+ H+ DL +A+ +++A N+G +G+F +A
Sbjct: 322 LYSCIGNAQIELGQMEAALQSHRKDLEIAKEYDLPDAKSRALDNIGRVFARVGKFQQAID 381
Query: 128 CCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLCK 187
+ + +A+ +K + IG Y + +W A N
Sbjct: 382 TWEEKIPLAKTTLEKTW---LFHEIGRCYLELDQ--AWQAQN------------------ 418
Query: 188 ASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAA 247
+ E++ +E GD Q A + L +F A ++ L AK + A
Sbjct: 419 ---YGEKSQQCAEEEGDIEWQLNASVLVAQAQVKLRDFESAVNNFEKALERAKLVHNNEA 475
Query: 248 ERRAYSNLGNAH 259
++ S L +A+
Sbjct: 476 QQAIISALDDAN 487
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/236 (21%), Positives = 96/236 (40%), Gaps = 21/236 (8%)
Query: 55 VQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGN 114
V+V LK+L + ++ LK R ++ ++L G ++ AKA GNLGN
Sbjct: 444 VKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRS--GIKVNPAKAWGNLGN 501
Query: 115 TLKVLGRFDEAAVCCQR-------------HLSIAQEQGDKVGEARALYNIGNVYHAKGK 161
LK + EA + +L + ++ + EA Y +
Sbjct: 502 VLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLA 561
Query: 162 QLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYL 221
N + G + R T K SE + NL +++ NLG ++
Sbjct: 562 SAYLNTGIILMNQGR-TEEARRTFLKCSEIPDENLK--DPHAHKSSVTSCLYNLGKLYHE 618
Query: 222 LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQ 277
G++ EA + +KE + ++ + A + Y+ +G A++ L + A +Y ++L+
Sbjct: 619 QGHYEEALSVYKEAI---QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLR 671
Score = 33.1 bits (74), Expect = 0.86
Identities = 54/225 (24%), Positives = 75/225 (33%), Gaps = 54/225 (24%)
Query: 66 SAIYSQLGNAYFYLKEHGR---ALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRF 122
S + L N L+E+ R AL Y+K IG R A A N G L GR
Sbjct: 524 SNMADMLYNLGLLLQENSRFAEALHYYK------LAIGSRPTLASAYLNTGIILMNQGRT 577
Query: 123 DEAAVCCQRHLSIAQEQ-----GDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHL 177
+EA + I E K LYN+G +YH +G
Sbjct: 578 EEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG----------------- 620
Query: 178 PPDVRETLCKASEFYERNLSLVKE----LGDRAAQGRAYGNLGNTHYLLGNFTEATTFHK 233
YE LS+ KE + + A Y +G + L EA ++
Sbjct: 621 -------------HYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYM 667
Query: 234 ERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQL 278
E L K A+ G GR A + + K ++L
Sbjct: 668 ESLR------SKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIEL 706
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 44.7 bits (104), Expect = 3e-04
Identities = 43/177 (24%), Positives = 81/177 (45%), Gaps = 21/177 (11%)
Query: 199 VKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNA 258
V E D + A NL +Y+ +F +A+++ +A+ + + AA +N GN
Sbjct: 449 VLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD--IAVNSDRYNPAA----LTNKGNT 502
Query: 259 HVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLI 318
G ++ AAE+YK+ LR+ + +A Y++G TY L + A + L+ I
Sbjct: 503 VFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAI 556
Query: 319 AQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQI---SQEIGDRHGELTAR 372
+ A+ + + N Y M P+QA+ + + + + ++ + GEL R
Sbjct: 557 LRNSAE------VLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 607
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 20/131 (15%)
Query: 67 AIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAA 126
A + GN F ++ +A E++K L + +A N+G T + L R DEA
Sbjct: 494 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSC------TEALYNIGLTYEKLNRLDEAL 547
Query: 127 VCCQRHLSIAQEQGDKVGEARALYNIGNVYHA---KGKQLSWNAANATQDPGHLPPDVRE 183
C + +I + A LY I N+Y + + W Q +P D +
Sbjct: 548 DCFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEW----LMQVVSVIPTD-PQ 596
Query: 184 TLCKASEFYER 194
L K E Y+R
Sbjct: 597 VLSKLGELYDR 607
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 44.7 bits (104), Expect = 3e-04
Identities = 43/177 (24%), Positives = 81/177 (45%), Gaps = 21/177 (11%)
Query: 199 VKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNA 258
V E D + A NL +Y+ +F +A+++ +A+ + + AA +N GN
Sbjct: 440 VLEKKDSRVKSAAATNLSALYYMGKDFAQASSYAD--IAVNSDRYNPAA----LTNKGNT 493
Query: 259 HVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLI 318
G ++ AAE+YK+ LR+ + +A Y++G TY L + A + L+ I
Sbjct: 494 VFANGDYEKAAEFYKEA------LRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAI 547
Query: 319 AQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQI---SQEIGDRHGELTAR 372
+ A+ + + N Y M P+QA+ + + + + ++ + GEL R
Sbjct: 548 LRNSAE------VLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 598
Score = 32.7 bits (73), Expect = 1.1
Identities = 34/131 (25%), Positives = 53/131 (40%), Gaps = 20/131 (15%)
Query: 67 AIYSQLGNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAA 126
A + GN F ++ +A E++K L + +A N+G T + L R DEA
Sbjct: 485 AALTNKGNTVFANGDYEKAAEFYKEALRNDSSC------TEALYNIGLTYEKLNRLDEAL 538
Query: 127 VCCQRHLSIAQEQGDKVGEARALYNIGNVYHA---KGKQLSWNAANATQDPGHLPPDVRE 183
C + +I + A LY I N+Y + + W Q +P D +
Sbjct: 539 DCFLKLHAILR------NSAEVLYQIANIYELMENPSQAIEW----LMQVVSVIPTD-PQ 587
Query: 184 TLCKASEFYER 194
L K E Y+R
Sbjct: 588 VLSKLGELYDR 598
>gi|148612821 tetratricopeptide repeat domain 29 [Homo sapiens]
Length = 475
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/111 (23%), Positives = 54/111 (48%)
Query: 250 RAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAA 309
R Y L + + + A + K +++++ D+ +EA+A Y LG + ++YE A
Sbjct: 235 RTYRLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEAEASYYLGLAHLAAEEYETAL 294
Query: 310 EYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ 360
+ I+ +L D + GR ++ S G +A+ + KK ++I++
Sbjct: 295 TVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIAR 345
Score = 40.0 bits (92), Expect = 0.007
Identities = 54/238 (22%), Positives = 92/238 (38%), Gaps = 40/238 (16%)
Query: 69 YSQLGNAYFYLKEHGRALEYHKHDLLLA--RTIGDRMGEAKASGNLGNTLKVLGRFDEAA 126
+ QL + E GR+L + LL R + D+M E K +K+L + E
Sbjct: 208 FHQLTQGRIWKDETGRSLNLLACESLLRTYRLLSDKMLENK---EYKQAIKILIKASE-- 262
Query: 127 VCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPDVRETLC 186
IA+E DK EA A Y +G A+ + V +T C
Sbjct: 263 --------IAKEGSDKKMEAEASYYLG-------------LAHLAAEEYETALTVLDTYC 301
Query: 187 KASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKA 246
K S +L D + GR Y + G TEA + K+ + IA+
Sbjct: 302 KIST----------DLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSL 351
Query: 247 AERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAV--EAQACYSLGNTYTLL 302
RA + LG+ + G ++ A+E +++ + +L + E + Y + + ++
Sbjct: 352 DLVRASTMLGDIYNEKGYYNKASECFQQAFDTTVELMSMPLMDETKVHYGIAKAHQMM 409
Score = 34.7 bits (78), Expect = 0.30
Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 7/126 (5%)
Query: 185 LCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244
L KASE + KE D+ + A LG H + A T I+ + D
Sbjct: 257 LIKASE-------IAKEGSDKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDD 309
Query: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQD 304
+ R Y + G A +Y KK ++++R +A LG+ Y
Sbjct: 310 DLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKGY 369
Query: 305 YERAAE 310
Y +A+E
Sbjct: 370 YNKASE 375
Score = 30.8 bits (68), Expect = 4.3
Identities = 26/106 (24%), Positives = 41/106 (38%)
Query: 238 IAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGN 297
IAKE DK E A LG AH+ ++ A ++S L D + ++
Sbjct: 263 IAKEGSDKKMEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAK 322
Query: 298 TYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMG 343
+ A +Y + + IA+ + RA LG+ Y G
Sbjct: 323 VLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRASTMLGDIYNEKG 368
>gi|29725607 smooth muscle cell associated protein-1 isoform 2 [Homo
sapiens]
Length = 944
Score = 39.7 bits (91), Expect = 0.009
Identities = 44/160 (27%), Positives = 67/160 (41%), Gaps = 10/160 (6%)
Query: 13 PGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQL 72
PG R + +S +L EG L K GD+ +A + A+ + D
Sbjct: 6 PGTPEPRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGL---DATPQDQAVLHR 62
Query: 73 GNAYFYLKEHGRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRH 132
A +LK +Y K + ++ I G+ KA L+ LGR D+A + QR
Sbjct: 63 NRAACHLKLE----DYDKAETEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRC 118
Query: 133 LSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQ 172
+S+ E +KV + AL NIG K + +S A Q
Sbjct: 119 VSL--EPKNKVFQ-EALRNIGGQIQEKVRYMSSTDAKVEQ 155
>gi|89179321 smooth muscle cell associated protein-1 isoform 3 [Homo
sapiens]
Length = 929
Score = 39.3 bits (90), Expect = 0.012
Identities = 44/150 (29%), Positives = 65/150 (43%), Gaps = 11/150 (7%)
Query: 24 MEASCLE-LALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEH 82
M AS +E L EG L K GD+ +A + A+ + D A +LK
Sbjct: 1 MTASSVEQLRKEGNELFKCGDYGGALAAYTQALGL---DATPQDQAVLHRNRAACHLKLE 57
Query: 83 GRALEYHKHDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDK 142
+Y K + ++ I G+ KA L+ LGR D+A + QR +S+ E +K
Sbjct: 58 ----DYDKAETEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLQRCVSL--EPKNK 111
Query: 143 VGEARALYNIGNVYHAKGKQLSWNAANATQ 172
V + AL NIG K + +S A Q
Sbjct: 112 VFQ-EALRNIGGQIQEKVRYMSSTDAKVEQ 140
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 38.9 bits (89), Expect = 0.016
Identities = 71/310 (22%), Positives = 120/310 (38%), Gaps = 53/310 (17%)
Query: 52 EAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALE--YHKHDLLLARTIGDRMGEAKAS 109
E+ + G + L + ++ N +LK+ GR E YH L A A
Sbjct: 361 ESLFRSGVQTLPHNAKVHYNYAN---FLKDQGRNKEAIYHYRTALKLYP-----RHASAL 412
Query: 110 GNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAAN 169
NLG + EA + QR L + + RAL+N+GN+ K ++ A
Sbjct: 413 NNLGTLTRDTA---EAKMYYQRALQLHPQHN------RALFNLGNLL--KSQEKKEEAIT 461
Query: 170 ATQDPGHLPPDV-------------RETLCKASEFYERNLSLVKELGDRAAQGRAYGNLG 216
+D P+ +E +A E Y+ + + D + N G
Sbjct: 462 LLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSD------LHNNYG 515
Query: 217 NTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTL 276
G +A +++ + ++ + A NLG + LG +A E+YK+ L
Sbjct: 516 VFLVDTGLPEKAVAHYQQAIKLSP------SHHVAMVNLGRLYRSLGENSMAEEWYKRAL 569
Query: 277 QLSRQLRDQAVEAQACYSLGNTYTLLQDYERAA-----EYHLRHLLIAQELADRVGEGRA 331
Q++ + + Y+ G LQ Y+ AA + LR L +AQ LA +G+ +
Sbjct: 570 QVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELR-LALAQVLA-VMGQTKE 627
Query: 332 CWSLGNAYVS 341
+ N VS
Sbjct: 628 AEKMTNHIVS 637
Score = 36.6 bits (83), Expect = 0.078
Identities = 54/208 (25%), Positives = 81/208 (38%), Gaps = 29/208 (13%)
Query: 155 VYHAK-GKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVKELGDRAAQGRAYG 213
+YH + +L A+A + G L D E A +Y+R L L + RA
Sbjct: 395 IYHYRTALKLYPRHASALNNLGTLTRDTAE----AKMYYQRALQLHPQ------HNRALF 444
Query: 214 NLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYK 273
NLGN EA T K+ + EF D AYS+L + RF A E Y+
Sbjct: 445 NLGNLLKSQEKKEEAITLLKDSIKYGPEFAD------AYSSLASLLAEQERFKEAEEIYQ 498
Query: 274 KTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACW 333
++ D L N Y + E + H A +L+ A
Sbjct: 499 TGIKNCPDSSD----------LHNNYGVFLVDTGLPEKAVAHYQQAIKLSP--SHHVAMV 546
Query: 334 SLGNAYVSMGRPAQALTFAKKHLQISQE 361
+LG Y S+G + A + K+ LQ++ +
Sbjct: 547 NLGRLYRSLGENSMAEEWYKRALQVAHK 574
Score = 33.1 bits (74), Expect = 0.86
Identities = 31/122 (25%), Positives = 51/122 (41%), Gaps = 15/122 (12%)
Query: 250 RAYSNLGNAHVFLGRFDVAAEYYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAA 309
+ + N N GR A +Y+ L+L + A A +LG TL +D A
Sbjct: 376 KVHYNYANFLKDQGRNKEAIYHYRTALKLYPR------HASALNNLG---TLTRDTAEAK 426
Query: 310 EYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQEIGDRHGEL 369
Y+ R L + + RA ++LGN S + +A+T K ++ E D + L
Sbjct: 427 MYYQRALQLHPQ------HNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480
Query: 370 TA 371
+
Sbjct: 481 AS 482
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 37.4 bits (85), Expect = 0.046
Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 13/131 (9%)
Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
+ E A E ++++L L K Q A G T + G EA KE L
Sbjct: 208 ISEDYATAHEDFQQSLELNKN------QPIAMLYKGLTFFHRGLLKEAIESFKEALKQKV 261
Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR-QLRDQAVEAQACYSLGNTY 299
+F D AY +LG A+ LG F+ A E ++K L L++ ++ + Y G+
Sbjct: 262 DFID------AYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQ 315
Query: 300 TLLQDYERAAE 310
L++++R +
Sbjct: 316 EALKNFKRCLQ 326
>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
sapiens]
Length = 860
Score = 37.4 bits (85), Expect = 0.046
Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 13/131 (9%)
Query: 181 VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAK 240
+ E A E ++++L L K Q A G T + G EA KE L
Sbjct: 261 ISEDYATAHEDFQQSLELNKN------QPIAMLYKGLTFFHRGLLKEAIESFKEALKQKV 314
Query: 241 EFGDKAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR-QLRDQAVEAQACYSLGNTY 299
+F D AY +LG A+ LG F+ A E ++K L L++ ++ + Y G+
Sbjct: 315 DFID------AYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQ 368
Query: 300 TLLQDYERAAE 310
L++++R +
Sbjct: 369 EALKNFKRCLQ 379
>gi|118402578 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 36.6 bits (83), Expect = 0.078
Identities = 23/96 (23%), Positives = 42/96 (43%), Gaps = 9/96 (9%)
Query: 188 ASEFYERNLSLVKELGDRAAQGR---AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244
A +++ L +K +G+ + NLG+ L + EA +H++ L + +
Sbjct: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQ--- 477
Query: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280
YS +G H +G F+ A +Y+ L L R
Sbjct: 478 ---NASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510
>gi|118402580 anaphase-promoting complex, subunit 6 [Homo sapiens]
Length = 620
Score = 36.6 bits (83), Expect = 0.078
Identities = 23/96 (23%), Positives = 42/96 (43%), Gaps = 9/96 (9%)
Query: 188 ASEFYERNLSLVKELGDRAAQGR---AYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGD 244
A +++ L +K +G+ + NLG+ L + EA +H++ L + +
Sbjct: 421 AEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQ--- 477
Query: 245 KAAERRAYSNLGNAHVFLGRFDVAAEYYKKTLQLSR 280
YS +G H +G F+ A +Y+ L L R
Sbjct: 478 ---NASTYSAIGYIHSLMGNFENAVDYFHTALGLRR 510
>gi|41871960 kinesin-like 8 isoform b [Homo sapiens]
Length = 637
Score = 34.7 bits (78), Expect = 0.30
Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 26/151 (17%)
Query: 98 TIG-DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
T+G D A NL G++ EA CQR L I ++ +G +
Sbjct: 304 TLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKV------------LGTNH 351
Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVK-ELG-DRAAQGRAYGN 214
KQL+ N A Q+ G +Y+R L++ + +LG D R N
Sbjct: 352 PDVAKQLN-NLALLCQNQGKYE--------AVERYYQRALAIYEGQLGPDNPNVARTKNN 402
Query: 215 LGNTHYLLGNFTEATTFHKERL--AIAKEFG 243
L + + G + EA T +KE L A +EFG
Sbjct: 403 LASCYLKQGKYAEAETLYKEILTRAHVQEFG 433
>gi|41871955 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 34.7 bits (78), Expect = 0.30
Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 26/151 (17%)
Query: 98 TIG-DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
T+G D A NL G++ EA CQR L I ++ +G +
Sbjct: 286 TLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKV------------LGTNH 333
Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVK-ELG-DRAAQGRAYGN 214
KQL+ N A Q+ G +Y+R L++ + +LG D R N
Sbjct: 334 PDVAKQLN-NLALLCQNQGKYE--------AVERYYQRALAIYEGQLGPDNPNVARTKNN 384
Query: 215 LGNTHYLLGNFTEATTFHKERL--AIAKEFG 243
L + + G + EA T +KE L A +EFG
Sbjct: 385 LASCYLKQGKYAEAETLYKEILTRAHVQEFG 415
>gi|41871946 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 34.7 bits (78), Expect = 0.30
Identities = 42/151 (27%), Positives = 62/151 (41%), Gaps = 26/151 (17%)
Query: 98 TIG-DRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVY 156
T+G D A NL G++ EA CQR L I ++ +G +
Sbjct: 286 TLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALEIREKV------------LGTNH 333
Query: 157 HAKGKQLSWNAANATQDPGHLPPDVRETLCKASEFYERNLSLVK-ELG-DRAAQGRAYGN 214
KQL+ N A Q+ G +Y+R L++ + +LG D R N
Sbjct: 334 PDVAKQLN-NLALLCQNQGKYE--------AVERYYQRALAIYEGQLGPDNPNVARTKNN 384
Query: 215 LGNTHYLLGNFTEATTFHKERL--AIAKEFG 243
L + + G + EA T +KE L A +EFG
Sbjct: 385 LASCYLKQGKYAEAETLYKEILTRAHVQEFG 415
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,264,291
Number of Sequences: 37866
Number of extensions: 1369787
Number of successful extensions: 4676
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 4303
Number of HSP's gapped (non-prelim): 218
length of query: 675
length of database: 18,247,518
effective HSP length: 109
effective length of query: 566
effective length of database: 14,120,124
effective search space: 7991990184
effective search space used: 7991990184
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.