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Search of human proteins with 224458284
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
(1397 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 2813 0.0
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 608 e-174
gi|188497642 ARHGAP15 [Homo sapiens] 158 4e-38
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 148 3e-35
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 146 2e-34
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 146 2e-34
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 130 7e-30
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 130 7e-30
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 129 2e-29
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 129 2e-29
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 128 3e-29
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 128 3e-29
gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapi... 121 5e-27
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 119 2e-26
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 119 2e-26
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 118 3e-26
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 114 7e-25
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 114 7e-25
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 112 2e-24
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 112 2e-24
gi|229094128 active breakpoint cluster region-related protein i... 112 3e-24
gi|38679957 active breakpoint cluster region-related protein is... 112 3e-24
gi|38679954 active breakpoint cluster region-related protein is... 112 3e-24
gi|4505507 oligophrenin 1 [Homo sapiens] 110 1e-23
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 109 2e-23
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 108 3e-23
gi|23510413 sorting nexin 26 [Homo sapiens] 108 4e-23
gi|54860079 nadrin isoform 1 [Homo sapiens] 107 6e-23
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 107 8e-23
gi|54860105 nadrin isoform 2 [Homo sapiens] 106 1e-22
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 2813 bits (7293), Expect = 0.0
Identities = 1397/1397 (100%), Positives = 1397/1397 (100%)
Query: 1 MDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPK 60
MDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPK
Sbjct: 1 MDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPK 60
Query: 61 DEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSA 120
DEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSA
Sbjct: 61 DEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSA 120
Query: 121 LPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPG 180
LPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPG
Sbjct: 121 LPSDPRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPG 180
Query: 181 SRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTS 240
SRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTS
Sbjct: 181 SRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTS 240
Query: 241 QDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPT 300
QDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPT
Sbjct: 241 QDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPACPT 300
Query: 301 RDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQS 360
RDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQS
Sbjct: 301 RDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQS 360
Query: 361 PASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFG 420
PASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFG
Sbjct: 361 PASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFG 420
Query: 421 DESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAM 480
DESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAM
Sbjct: 421 DESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAM 480
Query: 481 NSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDE 540
NSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDE
Sbjct: 481 NSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDE 540
Query: 541 GRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGW 600
GRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGW
Sbjct: 541 GRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGW 600
Query: 601 LYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAA 660
LYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAA
Sbjct: 601 LYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAA 660
Query: 661 PVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDP 720
PVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDP
Sbjct: 661 PVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDP 720
Query: 721 GCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAG 780
GCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAG
Sbjct: 721 GCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAG 780
Query: 781 SKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARG 840
SKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARG
Sbjct: 781 SKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARG 840
Query: 841 LESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFT 900
LESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFT
Sbjct: 841 LESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFT 900
Query: 901 DDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPR 960
DDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPR
Sbjct: 901 DDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPR 960
Query: 961 NLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEP 1020
NLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEP
Sbjct: 961 NLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEP 1020
Query: 1021 QAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNR 1080
QAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNR
Sbjct: 1021 QAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNR 1080
Query: 1081 KRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAA 1140
KRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAA
Sbjct: 1081 KRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAA 1140
Query: 1141 PEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAG 1200
PEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAG
Sbjct: 1141 PEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAG 1200
Query: 1201 AGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQES 1260
AGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQES
Sbjct: 1201 AGPGGRLTRRPSFSSHHLMPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGSASSSSQES 1260
Query: 1261 LRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPL 1320
LRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPL
Sbjct: 1261 LRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPL 1320
Query: 1321 TDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSL 1380
TDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSL
Sbjct: 1321 TDLNFNEWKELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSL 1380
Query: 1381 QSQPPRRSAASRLHQCL 1397
QSQPPRRSAASRLHQCL
Sbjct: 1381 QSQPPRRSAASRLHQCL 1397
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 608 bits (1569), Expect = e-174
Identities = 359/745 (48%), Positives = 471/745 (63%), Gaps = 75/745 (10%)
Query: 390 DRGDEVVLRQKPPTGRKVQLTPARQMN--LGFGDESPE-------PEASGRGERLGR--- 437
D + V+LR+KPP+GR+ P R + L D+ P + R + R
Sbjct: 730 DNKEAVILREKPPSGRQTP-QPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEE 788
Query: 438 -KVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFT 496
K + + DSLASIPFIDEPTSPSID H+PASAV+S++ + P + T P T +
Sbjct: 789 RKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPCLTTS 848
Query: 497 FTLGR------HYSQDCSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNR 550
L R H S S+ A S TERSKS D+GL+ +R++ ++ + +
Sbjct: 849 APLIRRQLSHDHESVGPPSLDAQPNSK------TERSKSYDEGLDDYREDAKLSFKHVSS 902
Query: 551 IPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKK 610
+ +++ DS +SED+ S D S FSD +EGWL+++ ++T K
Sbjct: 903 LKGIKIA---------DSQKSSEDSG------SRKDSSSEVFSDAAKEGWLHFRPLVTDK 947
Query: 611 GKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVD 670
GK+ G +R WK++Y LR SL L K++RE + +E P+ + +CL+D
Sbjct: 948 GKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPS----------EEEQPISVNACLID 997
Query: 671 ISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISK 730
ISYSETKR++VFRLTT+D CE LFQAEDRDDML WI+ I+E+S ED G N+ LIS+
Sbjct: 998 ISYSETKRKNVFRLTTSD-CECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISR 1056
Query: 731 KLNDYRKVSHSSGPKADSSPKGSRG-------LGGLKSEFLKQSAARGLRTQDLPAGSKD 783
++ +Y + KA+ PK R L G KSE QS + SKD
Sbjct: 1057 RIKEYNNLMS----KAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKD 1112
Query: 784 D-SAAAPKTPW--GI-NIIKKNKKAAPRA---FGVRLEECQPATENQRVPLIVAACCRIV 836
D S K W GI +I++K + P A FGVRL++C PA N+ +PLIV CC++V
Sbjct: 1113 DTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLV 1172
Query: 837 EARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPE 896
E RGLE TGIYRVPGNNA +SS+QE+LN+G DI++QD++W+DLNVISSLLKSFFRKLPE
Sbjct: 1173 EERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPE 1232
Query: 897 PLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNK 956
PLFT+DKY DFIEANR ED +R++TL++LI DLP H+YETLKFL HLKT+A++SEKNK
Sbjct: 1233 PLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNK 1292
Query: 957 MEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVG 1016
MEPRNLA+VFGPTLVRTSEDNMT MVTHMPD+YKIVETLIQH DWFF++E + T V
Sbjct: 1293 MEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQ 1352
Query: 1017 DK---EPQAVPNIEYLLPNIGRT-VPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAI 1072
++ + Q VPNI++LL NIGRT V PGD SDS T S KSKGSW K+ Y+RE+L
Sbjct: 1353 EESTVDSQPVPNIDHLLTNIGRTGVSPGDV-SDSATSDSTKSKGSWGSGKDQYSRELLVS 1411
Query: 1073 SFISAVNRKRKKRREARGLGSSTDD 1097
S +A +RKRKK +E SS D+
Sbjct: 1412 SIFAAASRKRKKPKEKAQPSSSEDE 1436
Score = 176 bits (446), Expect = 1e-43
Identities = 98/157 (62%), Positives = 109/157 (69%), Gaps = 18/157 (11%)
Query: 1 MDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPK 60
MDTIFVK VKE GPA AGL TGDR++KVNGESVIGKTYSQVIALIQNSD TLELS+MPK
Sbjct: 99 MDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPK 158
Query: 61 DEDILQ----------LAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTR 110
DEDILQ LAYSQDAYLKGNE YSG AR+IPEPPPICYP AP A A +
Sbjct: 159 DEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMA--Q 216
Query: 111 ATMVPEPTSALPSDPRSPAAWSDPG------LRVPPA 141
+ P S+L S + PG ++VPP+
Sbjct: 217 PVEISPPDSSLSKQQTSTPVLTQPGRAYRMEIQVPPS 253
Score = 62.8 bits (151), Expect = 2e-09
Identities = 83/302 (27%), Positives = 117/302 (38%), Gaps = 64/302 (21%)
Query: 1147 ADTRSIVSGYST------LSTMDRSVCSGASGRRAGA-GDEADDERSELSH----VETDT 1195
A+ +I S YST L+++D S S A + GDEADDERSEL VETD+
Sbjct: 1578 ANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADDERSELISEGRPVETDS 1637
Query: 1196 EGAAGAGPG--------------------------------GRLT-----RRPSFSSHHL 1218
E P G LT RR FSSH L
Sbjct: 1638 ESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKL 1697
Query: 1219 MPCDTLARRRLARGRPDGEGAGRGGPRAPEPPGS------ASSSSQESLRPPAAALASRP 1272
+ CDTL+R++ AR + D G P + S SL P + +
Sbjct: 1698 IECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGKSTGSLLTPTRGESEKQ 1757
Query: 1273 SR------MEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLN-F 1325
+ L+LR R ADDM V ++ ET +R+S RRHT+ T+++
Sbjct: 1758 EPTWKTKIADRLKLRPRAPADDMFGVG-NHKVNAETAKRKSIRRRHTLGGHRDATEISVL 1816
Query: 1326 NEWK--ELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQ 1383
N WK E G E + + S+ AR ++ + G+ G Q++
Sbjct: 1817 NFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDPQTE 1876
Query: 1384 PP 1385
P
Sbjct: 1877 NP 1878
Score = 33.5 bits (75), Expect = 1.5
Identities = 34/109 (31%), Positives = 47/109 (43%), Gaps = 14/109 (12%)
Query: 180 GSRVPPSRLECQQALSHWLSNQ---VPRRA---GERRCPA-------MAPRARSASQDRL 226
G R RL+ +A S ++ VP R G RR + + R RS SQ+RL
Sbjct: 404 GCRTIQERLDSLRAASQSTTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERL 463
Query: 227 EEVAAPRPWPCSTSQDALSQLGQE-GWHRARSDDYLSRATRSAEALGPG 274
E+ + P S SQ AL+ HR RS DY+ + E + G
Sbjct: 464 EDSVLMKYCPRSASQGALTSPSVSFSNHRTRSWDYIEGQDETLENVNSG 512
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 158 bits (399), Expect = 4e-38
Identities = 120/420 (28%), Positives = 199/420 (47%), Gaps = 30/420 (7%)
Query: 595 IRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA 654
+ +EG+L K + GKK + W + L +R + KE ++ A
Sbjct: 80 VEKEGYLQ-KAKIADGGKKLR---KNWSTSWIVLSSRRIEFYKESKQQ--------ALSN 127
Query: 655 GEDEAAPVCIGSCLVDISYSETK--RRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIREN 712
+ P + C I +++ K R++VF++TT E+L Q++ +L W AI+
Sbjct: 128 MKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNA 187
Query: 713 SRAEGEDPGCANQALISKKL---NDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAA 769
+D C ++ L K+ + +SH + P+ + L L SA+
Sbjct: 188 IDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSL----MFRLHHSAS 243
Query: 770 RGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLI 828
+ + K P + +++ + FG L + C+ EN VP
Sbjct: 244 DTSDKNRVKSRLKKFITRRPS----LKTLQEKGLIKDQIFGSHLHKVCE--RENSTVPWF 297
Query: 829 VAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLK 888
V C VE RGL+ GIYRV GN A + L+ +N+ +NL D +W+D++V++ LK
Sbjct: 298 VKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEE-KLNLDDSQWEDIHVVTGALK 356
Query: 889 SFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTI 948
FFR+LPEPLF + F+EA + +D R+ ++ L++ LP +T+K L GHL I
Sbjct: 357 MFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKI 416
Query: 949 ADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEED 1008
+ KN M ++L +VFGPTL+R +E+ +M HM + +I E ++ F EED
Sbjct: 417 VAKASKNLMSTQSLGIVFGPTLLR-AENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED 475
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 148 bits (374), Expect = 3e-35
Identities = 110/397 (27%), Positives = 195/397 (49%), Gaps = 41/397 (10%)
Query: 607 LTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCI-- 664
+ + GKK + W +A L+ SL +K + G++ + G +++ P
Sbjct: 475 IAENGKKVR---KNWLSSWAVLQGSSLLFTKTQ--------GSSTSWFGSNQSKPEFTVD 523
Query: 665 --GSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRE--NSRAEGEDP 720
G+ + S ++ +++VF L T E L Q+++ + W + + N++A D
Sbjct: 524 LKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDE 583
Query: 721 GCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAG 780
G + S + + K PK S K S + + + K++ + L +
Sbjct: 584 GIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVS-SIDSSEQKKTKKNLKKFLTRRPT--- 639
Query: 781 SKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLIVAACCRIVEAR 839
+ +++ + FG L CQ EN VP V C VE
Sbjct: 640 --------------LQAVREKGYIKDQVFGSNLANLCQ--RENGTVPKFVKLCIEHVEEH 683
Query: 840 GLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLF 899
GL+ GIYRV GN AV+ L+ +N ++L D +W+D++VI+ LK FFR+LPEPLF
Sbjct: 684 GLDIDGIYRVSGNLAVIQKLRFAVNHDE-KLDLNDSKWEDIHVITGALKMFFRELPEPLF 742
Query: 900 TDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEP 959
T + +NDF+ A + ++ R+R+ ++ LIR LP +T++ L HL+ + ++ EKN+M
Sbjct: 743 TFNHFNDFVNAIK-QEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTY 801
Query: 960 RNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLI 996
+++A+VFGPTL++ E ++ H + +IVE ++
Sbjct: 802 QSIAIVFGPTLLK-PEKETGNIAVHTVYQNQIVELIL 837
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 146 bits (368), Expect = 2e-34
Identities = 122/462 (26%), Positives = 214/462 (46%), Gaps = 42/462 (9%)
Query: 551 IPSLRMLRSFFTDGSLDSWGTSEDADAPSKRH---STSDLSDATFSDIRR---EGWLYYK 604
+P+ R + DG + + + P++ S ++S AT + + + + ++
Sbjct: 78 VPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHR 137
Query: 605 QILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA--GEDEAAPV 662
KGK+ + W + L L+ K+ + +AAG + E
Sbjct: 138 TKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKT---SAAGGLRQPSKFSTPEYTVE 192
Query: 663 CIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGED--P 720
G+ L ++ R++V L + D EYL Q + + W +AI + + + P
Sbjct: 193 LRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPP 252
Query: 721 GCANQALI----SKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQD 776
+ + + S++L +++ + P A + G GL +S+ K Q
Sbjct: 253 EESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGL---ESDLSKVRHKLRKFLQR 309
Query: 777 LPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLIVAACCRI 835
P + +++ + FG L C+ E RVP V C R
Sbjct: 310 RPT---------------LQSLREKGYIKDQVFGCALAALCE--RERSRVPRFVQQCIRA 352
Query: 836 VEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLP 895
VEARGL+ G+YR+ GN A + L+ +++ ++L D RW+D++VI+ LK FFR+LP
Sbjct: 353 VEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGALKLFFRELP 411
Query: 896 EPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKN 955
EPLF + FI A +++D R R +R L+R LP ++TL+ L HL + +H E+N
Sbjct: 412 EPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQN 471
Query: 956 KMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQ 997
+M +++A+VFGPTL+R E T M M + ++VE ++Q
Sbjct: 472 RMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 512
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 146 bits (368), Expect = 2e-34
Identities = 122/462 (26%), Positives = 214/462 (46%), Gaps = 42/462 (9%)
Query: 551 IPSLRMLRSFFTDGSLDSWGTSEDADAPSKRH---STSDLSDATFSDIRR---EGWLYYK 604
+P+ R + DG + + + P++ S ++S AT + + + + ++
Sbjct: 105 VPAPRSIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHR 164
Query: 605 QILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA--GEDEAAPV 662
KGK+ + W + L L+ K+ + +AAG + E
Sbjct: 165 TKTADKGKRLRK--KHWSASWTVLEGGVLTFFKDSKT---SAAGGLRQPSKFSTPEYTVE 219
Query: 663 CIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIRENSRAEGED--P 720
G+ L ++ R++V L + D EYL Q + + W +AI + + + P
Sbjct: 220 LRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPP 279
Query: 721 GCANQALI----SKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAARGLRTQD 776
+ + + S++L +++ + P A + G GL +S+ K Q
Sbjct: 280 EESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGL---ESDLSKVRHKLRKFLQR 336
Query: 777 LPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLIVAACCRI 835
P + +++ + FG L C+ E RVP V C R
Sbjct: 337 RPT---------------LQSLREKGYIKDQVFGCALAALCE--RERSRVPRFVQQCIRA 379
Query: 836 VEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLP 895
VEARGL+ G+YR+ GN A + L+ +++ ++L D RW+D++VI+ LK FFR+LP
Sbjct: 380 VEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGRWEDVHVITGALKLFFRELP 438
Query: 896 EPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKN 955
EPLF + FI A +++D R R +R L+R LP ++TL+ L HL + +H E+N
Sbjct: 439 EPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQN 498
Query: 956 KMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQ 997
+M +++A+VFGPTL+R E T M M + ++VE ++Q
Sbjct: 499 RMSVQSVAIVFGPTLLR-PEVEETSMPMTMVFQNQVVELILQ 539
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 130 bits (328), Expect = 7e-30
Identities = 75/227 (33%), Positives = 121/227 (53%), Gaps = 24/227 (10%)
Query: 794 GINIIKKNKKAAPRAFGVRLEECQP-----------------ATENQRVPLIVAACCRIV 836
G+N+ K+ K P +CQP N + P++V C R +
Sbjct: 249 GLNVHKQCSKHVPN-------DCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREI 301
Query: 837 EARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPE 896
EARGL+S G+YRV G + ++ +R ++ + D+N+I+ LK +FR LP
Sbjct: 302 EARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPI 361
Query: 897 PLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNK 956
P+ T D Y+ FI+A +I +A ER+ + +++ LP +YETL++L+ HLK + + + N
Sbjct: 362 PVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNF 421
Query: 957 MEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFF 1003
M NL +VFGPTL+R ED+ + M + IV+ LI++ D F
Sbjct: 422 MNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 468
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 130 bits (328), Expect = 7e-30
Identities = 75/227 (33%), Positives = 121/227 (53%), Gaps = 24/227 (10%)
Query: 794 GINIIKKNKKAAPRAFGVRLEECQP-----------------ATENQRVPLIVAACCRIV 836
G+N+ K+ K P +CQP N + P++V C R +
Sbjct: 113 GLNVHKQCSKHVPN-------DCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIREI 165
Query: 837 EARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPE 896
EARGL+S G+YRV G + ++ +R ++ + D+N+I+ LK +FR LP
Sbjct: 166 EARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPI 225
Query: 897 PLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNK 956
P+ T D Y+ FI+A +I +A ER+ + +++ LP +YETL++L+ HLK + + + N
Sbjct: 226 PVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNF 285
Query: 957 MEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFF 1003
M NL +VFGPTL+R ED+ + M + IV+ LI++ D F
Sbjct: 286 MNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 332
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 129 bits (325), Expect = 2e-29
Identities = 71/208 (34%), Positives = 118/208 (56%), Gaps = 1/208 (0%)
Query: 796 NIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAV 855
N K + K + + L A +R P++V C R +E+RGL S G+YRV G + +
Sbjct: 253 NDCKPDLKHVKKVYSCDLTTLVKAHTTKR-PMVVDMCIREIESRGLNSEGLYRVSGFSDL 311
Query: 856 VSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIED 915
+ ++ +R ++ ++D+N+I+ LK +FR LP PL T D Y FIE+ +I D
Sbjct: 312 IEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMD 371
Query: 916 ARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975
E++ TL + ++ LP + ETL++L+ HLK + H ++N M NL +VFGPTL+R+ E
Sbjct: 372 PDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE 431
Query: 976 DNMTDMVTHMPDRYKIVETLIQHSDWFF 1003
+ + + + +VE LI++ D F
Sbjct: 432 LDAMAALNDIRYQRLVVELLIKNEDILF 459
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 129 bits (325), Expect = 2e-29
Identities = 71/208 (34%), Positives = 118/208 (56%), Gaps = 1/208 (0%)
Query: 796 NIIKKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAV 855
N K + K + + L A +R P++V C R +E+RGL S G+YRV G + +
Sbjct: 227 NDCKPDLKHVKKVYSCDLTTLVKAHTTKR-PMVVDMCIREIESRGLNSEGLYRVSGFSDL 285
Query: 856 VSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIED 915
+ ++ +R ++ ++D+N+I+ LK +FR LP PL T D Y FIE+ +I D
Sbjct: 286 IEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMD 345
Query: 916 ARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975
E++ TL + ++ LP + ETL++L+ HLK + H ++N M NL +VFGPTL+R+ E
Sbjct: 346 PDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPE 405
Query: 976 DNMTDMVTHMPDRYKIVETLIQHSDWFF 1003
+ + + + +VE LI++ D F
Sbjct: 406 LDAMAALNDIRYQRLVVELLIKNEDILF 433
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 128 bits (322), Expect = 3e-29
Identities = 108/387 (27%), Positives = 177/387 (45%), Gaps = 39/387 (10%)
Query: 619 RQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKR 678
+ W + L SL REP P A + AG + V + + + R
Sbjct: 343 KNWGPSWVVLTGNSLVFY---REPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR 399
Query: 679 RHVFRLTTADFCEYLFQAEDRDDMLGWIRAIREN-SRAEGEDPGCANQALISKKLNDYRK 737
R+V + T E+L Q++ ++ W RA+R R + E+P + +L+
Sbjct: 400 RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENP-------LELRLSGSGP 452
Query: 738 VSHSSGP-KADSSPKGSRGLGGLKSEFLKQSAARGLR-TQDLPAGSKDDSAAAPKTPWGI 795
S+G + + S S+ L L S ++S+ RG T+ +K A + P +
Sbjct: 453 AELSAGEDEEEESELVSKPLLRLSS---RRSSIRGPEGTEQNRVRNKLKRLIAKRPP--L 507
Query: 796 NIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNA 854
+++ + FG +LE CQ E VP + C V+ RGL+ GIYRV GN A
Sbjct: 508 QSLQERGLLRDQVFGCQLESLCQ--REGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLA 565
Query: 855 VVSSLQEQLNRG-----------------PGDINLQDERWQDLNVISSLLKSFFRKLPEP 897
VV L+ ++R G ++L W D++V++ LK F R+LP+P
Sbjct: 566 VVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQP 625
Query: 898 LFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKM 957
L F A + ++ + + +++LI +P ++TL++L+ HL + HS+KN+M
Sbjct: 626 LVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRM 685
Query: 958 EPRNLALVFGPTLVRTSEDNMTDMVTH 984
P NL +VFGPTL R E +D H
Sbjct: 686 TPHNLGIVFGPTLFR-PEQETSDPAAH 711
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 128 bits (322), Expect = 3e-29
Identities = 108/387 (27%), Positives = 177/387 (45%), Gaps = 39/387 (10%)
Query: 619 RQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKR 678
+ W + L SL REP P A + AG + V + + + R
Sbjct: 159 KNWGPSWVVLTGNSLVFY---REPPPTAPSSGWGPAGSRPESSVDLRGAALAHGRHLSSR 215
Query: 679 RHVFRLTTADFCEYLFQAEDRDDMLGWIRAIREN-SRAEGEDPGCANQALISKKLNDYRK 737
R+V + T E+L Q++ ++ W RA+R R + E+P + +L+
Sbjct: 216 RNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENP-------LELRLSGSGP 268
Query: 738 VSHSSGP-KADSSPKGSRGLGGLKSEFLKQSAARGLR-TQDLPAGSKDDSAAAPKTPWGI 795
S+G + + S S+ L L S ++S+ RG T+ +K A + P +
Sbjct: 269 AELSAGEDEEEESELVSKPLLRLSS---RRSSIRGPEGTEQNRVRNKLKRLIAKRPP--L 323
Query: 796 NIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNA 854
+++ + FG +LE CQ E VP + C V+ RGL+ GIYRV GN A
Sbjct: 324 QSLQERGLLRDQVFGCQLESLCQ--REGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLA 381
Query: 855 VVSSLQEQLNRG-----------------PGDINLQDERWQDLNVISSLLKSFFRKLPEP 897
VV L+ ++R G ++L W D++V++ LK F R+LP+P
Sbjct: 382 VVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQP 441
Query: 898 LFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKM 957
L F A + ++ + + +++LI +P ++TL++L+ HL + HS+KN+M
Sbjct: 442 LVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDKNRM 501
Query: 958 EPRNLALVFGPTLVRTSEDNMTDMVTH 984
P NL +VFGPTL R E +D H
Sbjct: 502 TPHNLGIVFGPTLFR-PEQETSDPAAH 527
>gi|44917604 SLIT-ROBO Rho GTPase activating protein 1 [Homo sapiens]
Length = 1085
Score = 121 bits (303), Expect = 5e-27
Identities = 69/215 (32%), Positives = 119/215 (55%), Gaps = 8/215 (3%)
Query: 799 KKNKKAAPRA-FGVRLEECQPAT----ENQRVPLIVAACCRIVEARGLESTGIYRVPGNN 853
+K++K+ PR+ + +L T Q +PLIV +C R + GL+ GI+RV G+
Sbjct: 488 QKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGIFRVSGSQ 547
Query: 854 AVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRI 913
V+ ++ RG + D+ D+N ++ +LK +FR L PLF +++ND I RI
Sbjct: 548 VEVNDIKNSFERGENPL-ADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRI 606
Query: 914 EDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRT 973
++ ER +RKL+ LP +++L L ++ +S++N M+P NLA+ FGPTL+
Sbjct: 607 DNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPV 666
Query: 974 SEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEED 1008
E + D V+ +I++T+I H + F D ++
Sbjct: 667 PE--IQDQVSCQAHVNEIIKTIIIHHETIFPDAKE 699
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sapiens]
Length = 890
Score = 119 bits (298), Expect = 2e-26
Identities = 119/413 (28%), Positives = 187/413 (45%), Gaps = 44/413 (10%)
Query: 799 KKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSS 858
KK A R FG L+E Q VP ++ +C VE G+ GIYR+ G ++ +
Sbjct: 8 KKKGSAKERVFGCDLQE-HLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
Query: 859 LQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARE 918
L+++ +D QD++ +SSL K++FR+LP+PL T Y+ F EA ++ E
Sbjct: 66 LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
Query: 919 RMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRT----- 973
R+ + +++R+LP Y TL+FL+ HL +A S + M RNLA+V+ P L+R+
Sbjct: 126 RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
Query: 974 SEDNMTDMVTHMPDRYKIVETLIQHSDWFF------SDEEDKGERTPVG--------DKE 1019
S N T + + +VE ++ H D F E + G R+ G D
Sbjct: 186 SGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLM 245
Query: 1020 PQAVPNIEYLLPNI---GRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFIS 1076
P+ +P Y LP+I G P P + K KGS +K R + + S
Sbjct: 246 PRPLP---YHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRK---WRSIFNLG-RS 298
Query: 1077 AVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQG------PLPGAVAPE 1130
KRK R A ++ + + A + + A G + P+G P P + PE
Sbjct: 299 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE 358
Query: 1131 APGRLSPPAAP-EERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEAD 1182
+ S AA E+ P A+ + G ++ R +G S RAG A+
Sbjct: 359 SLENDSIEAAEGEQEPEAEA---LGGTNSEPGTPR---AGRSAIRAGGSSRAE 405
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sapiens]
Length = 1101
Score = 119 bits (298), Expect = 2e-26
Identities = 119/413 (28%), Positives = 187/413 (45%), Gaps = 44/413 (10%)
Query: 799 KKNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSS 858
KK A R FG L+E Q VP ++ +C VE G+ GIYR+ G ++ +
Sbjct: 8 KKKGSAKERVFGCDLQE-HLQHSGQEVPQVLKSCAEFVEEYGVVD-GIYRLSGVSSNIQK 65
Query: 859 LQEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARE 918
L+++ +D QD++ +SSL K++FR+LP+PL T Y+ F EA ++ E
Sbjct: 66 LRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPE 125
Query: 919 RMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRT----- 973
R+ + +++R+LP Y TL+FL+ HL +A S + M RNLA+V+ P L+R+
Sbjct: 126 RLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEA 185
Query: 974 SEDNMTDMVTHMPDRYKIVETLIQHSDWFF------SDEEDKGERTPVG--------DKE 1019
S N T + + +VE ++ H D F E + G R+ G D
Sbjct: 186 SGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGAALSGGEVESGWRSLPGTRASGSPEDLM 245
Query: 1020 PQAVPNIEYLLPNI---GRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFIS 1076
P+ +P Y LP+I G P P + K KGS +K R + + S
Sbjct: 246 PRPLP---YHLPSILQAGDGPPQMRPYHTIIEIAEHKRKGSLKVRK---WRSIFNLG-RS 298
Query: 1077 AVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGATAPGTQERPQG------PLPGAVAPE 1130
KRK R A ++ + + A + + A G + P+G P P + PE
Sbjct: 299 GHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAAAGASDEPEGLVGPSSPRPSPLLPE 358
Query: 1131 APGRLSPPAAP-EERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEAD 1182
+ S AA E+ P A+ + G ++ R +G S RAG A+
Sbjct: 359 SLENDSIEAAEGEQEPEAEA---LGGTNSEPGTPR---AGRSAIRAGGSSRAE 405
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 118 bits (296), Expect = 3e-26
Identities = 89/297 (29%), Positives = 140/297 (47%), Gaps = 35/297 (11%)
Query: 780 GSKDDSAAAP----KTPWGINIIK------KNKKAAPRA-----------FGVRLEECQP 818
G K D+A P + P NI++ K K PR FGV L
Sbjct: 1197 GYKGDNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTV-- 1254
Query: 819 ATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQ-DERW 877
T + +P+ + C +EA GL + GIYRV GN + + SLQ Q ++ D NL E+
Sbjct: 1255 VTPEKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQ---DHNLDLAEKD 1311
Query: 878 QDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYET 937
+N ++ +KSFF +LP+PL + D +EA++I D +++ L+++++ P +E
Sbjct: 1312 FTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEV 1371
Query: 938 LKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQ 997
K+++ HL ++ +++ N M NL++ F PTL+R M D +T I+E IQ
Sbjct: 1372 FKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTM-DALTATRTYQTIIELFIQ 1430
Query: 998 HSDWFFSDE---EDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSS 1051
+FF + E G R P AV + L + T P P S T S
Sbjct: 1431 QCPFFFYNRPITEPPGAR----PSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQS 1483
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo
sapiens]
Length = 1075
Score = 114 bits (285), Expect = 7e-25
Identities = 63/209 (30%), Positives = 117/209 (55%), Gaps = 7/209 (3%)
Query: 823 QRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNV 882
Q +PL+V +C R + GL+ GI+RVPG+ V+ ++ RG + + D+ +D+N
Sbjct: 493 QAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL-VDDQNERDINS 551
Query: 883 ISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLV 942
++ +LK +FR L PLF +++ D I ++E+ ER+ +++++ LP +++L
Sbjct: 552 VAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLF 611
Query: 943 GHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWF 1002
L ++ +S++N M+P NLA+ FGPTL+ + D V+ ++++T+I H +
Sbjct: 612 AFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAI 669
Query: 1003 F-SDEEDKG---ERTPVGDKEPQAVPNIE 1027
F S E +G E+ G +E P+ E
Sbjct: 670 FPSPRELEGPVYEKCMAGGEEYCDSPHSE 698
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo
sapiens]
Length = 1099
Score = 114 bits (285), Expect = 7e-25
Identities = 63/209 (30%), Positives = 117/209 (55%), Gaps = 7/209 (3%)
Query: 823 QRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNV 882
Q +PL+V +C R + GL+ GI+RVPG+ V+ ++ RG + + D+ +D+N
Sbjct: 517 QAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL-VDDQNERDINS 575
Query: 883 ISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLV 942
++ +LK +FR L PLF +++ D I ++E+ ER+ +++++ LP +++L
Sbjct: 576 VAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLF 635
Query: 943 GHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWF 1002
L ++ +S++N M+P NLA+ FGPTL+ + D V+ ++++T+I H +
Sbjct: 636 AFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQ--DPVSCQAHINEVIKTIIIHHEAI 693
Query: 1003 F-SDEEDKG---ERTPVGDKEPQAVPNIE 1027
F S E +G E+ G +E P+ E
Sbjct: 694 FPSPRELEGPVYEKCMAGGEEYCDSPHSE 722
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 112 bits (280), Expect = 2e-24
Identities = 65/167 (38%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 809 FGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPG 868
FGV++ E +VP IV C +E RG+E GIYRV G + +L+ +
Sbjct: 1008 FGVKIAVVTKR-ERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1066
Query: 869 DINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIR 928
D+++ D+N I+ LK +FR+LPEPLFTD+ Y +F E + D + + L+
Sbjct: 1067 DVSVMMSE-MDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1125
Query: 929 DLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975
LP T FL+ HLK +A+ NKM NLA VFGPTL+R SE
Sbjct: 1126 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1172
Score = 36.6 bits (83), Expect = 0.17
Identities = 28/84 (33%), Positives = 36/84 (42%), Gaps = 4/84 (4%)
Query: 1199 AGAGPGGRLTRRPSFSSHHLMPCDTL--ARRRLARGRPDGEGA-GRGGPRAPEPPGSASS 1255
A P G R S S P D RPDGEG+ G+ P PG+A+S
Sbjct: 80 AAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAAS 139
Query: 1256 SSQESLRPPAAALASRPSRMEALR 1279
++ PPA+ A R S E +R
Sbjct: 140 GERDDRGPPASVAALR-SNFERIR 162
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 112 bits (280), Expect = 2e-24
Identities = 65/167 (38%), Positives = 91/167 (54%), Gaps = 2/167 (1%)
Query: 809 FGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPG 868
FGV++ E +VP IV C +E RG+E GIYRV G + +L+ +
Sbjct: 1052 FGVKIAVVTKR-ERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNK 1110
Query: 869 DINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIR 928
D+++ D+N I+ LK +FR+LPEPLFTD+ Y +F E + D + + L+
Sbjct: 1111 DVSVMMSE-MDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1169
Query: 929 DLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975
LP T FL+ HLK +A+ NKM NLA VFGPTL+R SE
Sbjct: 1170 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSE 1216
Score = 36.6 bits (83), Expect = 0.17
Identities = 28/84 (33%), Positives = 36/84 (42%), Gaps = 4/84 (4%)
Query: 1199 AGAGPGGRLTRRPSFSSHHLMPCDTL--ARRRLARGRPDGEGA-GRGGPRAPEPPGSASS 1255
A P G R S S P D RPDGEG+ G+ P PG+A+S
Sbjct: 80 AAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRPGAAAS 139
Query: 1256 SSQESLRPPAAALASRPSRMEALR 1279
++ PPA+ A R S E +R
Sbjct: 140 GERDDRGPPASVAALR-SNFERIR 162
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 112 bits (279), Expect = 3e-24
Identities = 67/167 (40%), Positives = 89/167 (53%), Gaps = 2/167 (1%)
Query: 809 FGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPG 868
FGV++ E +VP IV C VE RG+E GIYR+ G + +L+ +
Sbjct: 599 FGVKISVVTKR-ERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 657
Query: 869 DINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIR 928
DI L D+N I+ LK +FR+LPEPL TD Y F+E + D + + L+R
Sbjct: 658 DILLMLSD-MDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLR 716
Query: 929 DLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975
LP T FL+ HLK +A+ NKM NLA VFGPTL+R SE
Sbjct: 717 SLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSE 763
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 112 bits (279), Expect = 3e-24
Identities = 67/167 (40%), Positives = 89/167 (53%), Gaps = 2/167 (1%)
Query: 809 FGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPG 868
FGV++ E +VP IV C VE RG+E GIYR+ G + +L+ +
Sbjct: 645 FGVKISVVTKR-ERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 703
Query: 869 DINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIR 928
DI L D+N I+ LK +FR+LPEPL TD Y F+E + D + + L+R
Sbjct: 704 DILLMLSD-MDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLR 762
Query: 929 DLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975
LP T FL+ HLK +A+ NKM NLA VFGPTL+R SE
Sbjct: 763 SLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSE 809
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 112 bits (279), Expect = 3e-24
Identities = 67/167 (40%), Positives = 89/167 (53%), Gaps = 2/167 (1%)
Query: 809 FGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPG 868
FGV++ E +VP IV C VE RG+E GIYR+ G + +L+ +
Sbjct: 608 FGVKISVVTKR-ERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNK 666
Query: 869 DINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIR 928
DI L D+N I+ LK +FR+LPEPL TD Y F+E + D + + L+R
Sbjct: 667 DILLMLSD-MDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLR 725
Query: 929 DLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSE 975
LP T FL+ HLK +A+ NKM NLA VFGPTL+R SE
Sbjct: 726 SLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSE 772
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 110 bits (274), Expect = 1e-23
Identities = 62/206 (30%), Positives = 108/206 (52%), Gaps = 10/206 (4%)
Query: 818 PATENQRVPL------IVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQL--NRGPGD 869
P T+ Q + L V C I+E +G+++ G+YR G+N V L + PGD
Sbjct: 373 PITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGD 432
Query: 870 INLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRD 929
++ + W D+ I+S LK + R L EP+ T + + + A + ++ R+ + L+
Sbjct: 433 VDFHNSDW-DIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYK 491
Query: 930 LPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRY 989
LP E L+ L+ HL + +HS++N M P N+ ++FGPTL+R ED + M+ ++ +
Sbjct: 492 LPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM-NIKFQN 550
Query: 990 KIVETLIQHSDWFFSDEEDKGERTPV 1015
+VE LI+H + ++ PV
Sbjct: 551 IVVEILIEHFGKIYLGPPEESAAPPV 576
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 109 bits (272), Expect = 2e-23
Identities = 128/537 (23%), Positives = 226/537 (42%), Gaps = 72/537 (13%)
Query: 808 AFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGP 867
+FG LEE + + + AC ++ G++ G++RV + + + L+ L+
Sbjct: 252 SFGKPLEE-HLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCV 310
Query: 868 GDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLI 927
D+ E D + I+ LKS+ R+LPEPL T + Y+++I+A+ +++ ++++ L
Sbjct: 311 VDVQ---EYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNAC 367
Query: 928 RDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV-RTSEDNMTDMVTHMP 986
LP + +++L+ L ++++ + NKM P N+A+V GP L+ +E N+T+M+T +
Sbjct: 368 EKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVS 427
Query: 987 -DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSD 1045
I+E +IQH+DWFF E IE+ + G P +
Sbjct: 428 LQIVGIIEPIIQHADWFFPGE-------------------IEFNI--TGNYGSPVHVNHN 466
Query: 1046 STTCSSAKSKGSWAPKKEP-YAREMLAISFISAVNRKRKK--RREARGLGSSTDDDSEQE 1102
+ S A +++P AR L+++ + + KK R+ + +G D +
Sbjct: 467 ANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVA 526
Query: 1103 AHKPGAG---ATAPGTQERP------QGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIV 1153
AG + AP + + P PLP + PE P L PAAP P+ +
Sbjct: 527 RRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPL-PEQP--LDSPAAPALSPSG--LGLQ 581
Query: 1154 SGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSF 1213
G ST S S ++ G + + + + + A G ++ P+
Sbjct: 582 PGPERTSTTKSKELSPGSAQK---GSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPAD 638
Query: 1214 SSHHLMPCDTLARRRLAR-------GRPDG---EGAGRGGP--RAPEPPGSAS------- 1254
S H + ++LA G+P + AG+ P +P PP + S
Sbjct: 639 QSPHTL---RKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYP 695
Query: 1255 ---SSSQESLRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSS 1308
S + L P AA + PS + + R T L P P SS
Sbjct: 696 QGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPTVNLSASS 752
Score = 36.6 bits (83), Expect = 0.17
Identities = 56/236 (23%), Positives = 84/236 (35%), Gaps = 29/236 (12%)
Query: 82 SGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPA 141
S R + PP + PPA + A +P P P D + A S GL + P
Sbjct: 530 SSAGRKVSCAPP------SMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPG 583
Query: 142 ARAHLDNSSLGM---SQPRPSPGAFPHLSSEPRTPRAFP--EPGSRVPPSRLECQQALSH 196
S + S + SPG+ + P A P +PG+ PS+ Q
Sbjct: 584 PERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQ---- 639
Query: 197 WLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRAR 256
S R+ ++ P + P+ + + +A +P P S S S G
Sbjct: 640 --SPHTLRKVSKKLAP-IPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGL---- 692
Query: 257 SDDYLSRATRSAEALGPGA---LVSPRFERCGWASQRSSARTPACPTRDLPGPQAP 309
Y + ++ L P A L SP + R + + PT LP PQ P
Sbjct: 693 --SYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPT--LPPPQPP 744
>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
Length = 1136
Score = 108 bits (271), Expect = 3e-23
Identities = 98/347 (28%), Positives = 151/347 (43%), Gaps = 35/347 (10%)
Query: 825 VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS 884
VP IV C +E R L + GIYRV G V L + G + L D IS
Sbjct: 774 VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHD---IS 830
Query: 885 SLLKSFFRKLPEPLFTDDKYN-------DFIEANRIEDARERMRT--------------- 922
++LK + R+LPEPL + Y+ D ++A A R R
Sbjct: 831 NVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGR 890
Query: 923 LRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMV 982
LR+L+RDLP +L++L+ HL+ I + + NKM P NL +VFGPTL+R T +
Sbjct: 891 LRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSL 950
Query: 983 THM---PDRYKIVETLIQHSDWFFSD--EEDKGERTPVGDKEPQAVPNIEYLLPNIGRTV 1037
+ + P + +++ETLI H F + EE G + ++ + V + YL
Sbjct: 951 SSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVY 1010
Query: 1038 PPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNR---KRKKRREARGLGSS 1094
P + +D S S S + +E A E+L+ S SA+ +++ EA +S
Sbjct: 1011 PLQEAAADGCRESRVVSNDSDSDLEE--ASELLSSSEASALGHLSFLEQQQSEASLEVAS 1068
Query: 1095 TDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAP 1141
+E + A G ++ P L G ++ L P P
Sbjct: 1069 GSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPP 1115
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 108 bits (270), Expect = 4e-23
Identities = 109/385 (28%), Positives = 163/385 (42%), Gaps = 50/385 (12%)
Query: 807 RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNR- 865
R FG L E + Q VP ++ C +EA G+ GIYR+ G ++ + L+ + +
Sbjct: 311 RVFGCDLGE-HLSNSGQDVPQVLRCCSEFIEAHGVVD-GIYRLSGVSSNIQRLRHEFDSE 368
Query: 866 ------GPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARER 919
GP + QD++ +SSL K +FR+LP PL T Y F EA + ER
Sbjct: 369 RIPELSGPAFL-------QDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEER 421
Query: 920 MRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMT 979
+ + +I+ LP +Y TL++L+ HL +A HS M RNLA+V+ P L+R+ E
Sbjct: 422 LVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESV 481
Query: 980 DM-----VTHMPDRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIG 1034
M + + +VE L+ H D FSD P G LLP
Sbjct: 482 GMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAG----------RCLLPR-P 530
Query: 1035 RTVPPGDPGSDSTTC--SSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLG 1092
+++ P + T + A+++G EP + A A RK ++ + R G
Sbjct: 531 KSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPA---SPAERRKGERGEKQRKPG 587
Query: 1093 SSTDDDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSI 1152
S S + G G + P +++P L G AP P P RS
Sbjct: 588 GS----SWKTFFALGRGPSVP--RKKPLPWLGGTRAPPQPSGSRP-------DTVTLRSA 634
Query: 1153 VSGYSTLSTMDRSVCSGASGRRAGA 1177
S S S + GA G A A
Sbjct: 635 KSEESLSSQASGAELLGAGGAPASA 659
Score = 33.1 bits (74), Expect = 1.9
Identities = 33/113 (29%), Positives = 44/113 (38%), Gaps = 12/113 (10%)
Query: 80 PYSGEARSI-------PEPPPICYPRKTYAPPARASTRATM-VPEPTSALPSDPRSPAAW 131
PYSG RS P+ Y +PP S + P S P D +A
Sbjct: 935 PYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAP 994
Query: 132 SDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVP 184
P R P ++ N +LG P P+ + SS P PR+ +PG VP
Sbjct: 995 QHPARRPTPPEPLYV-NLALGPRGPSPASSSS---SSPPAHPRSRSDPGPPVP 1043
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 107 bits (268), Expect = 6e-23
Identities = 137/617 (22%), Positives = 236/617 (38%), Gaps = 101/617 (16%)
Query: 800 KNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSL 859
++K A AFG LEE + + L + AC ++ G++ G++R+ + + L
Sbjct: 241 QDKWAEKPAFGTPLEE-HLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKL 299
Query: 860 QEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARER 919
+ L+ + DE + D + ++ LKS+ R+LPEPL T + Y ++ + ++D ++
Sbjct: 300 KAALDCSTSHL---DEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKK 356
Query: 920 MRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV-RTSEDNM 978
++ L + + LP + ++L+ L +A S+ NKM P N+A+V GP L+ +E +
Sbjct: 357 LQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTL 416
Query: 979 TDMVTHMPDR-YKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRT- 1036
+M ++E +IQH+DWFF +E +E+ N+
Sbjct: 417 AEMAAATSVHVVAVIEPIIQHADWFFPEE-------------------VEF---NVSEAF 454
Query: 1037 VPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTD 1096
VP P S+ + + S +K P + ++ + ++E+ G+
Sbjct: 455 VPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLV---------KKESFGVKL--- 502
Query: 1097 DDSEQEAHKPGAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGY 1156
+ +AH+ G Q PL P G PA PE P + SG
Sbjct: 503 --MDFQAHRRGGTLNRKHISPAFQPPL-----PPTDGSTVVPAGPEPPPQSSRAESSSGG 555
Query: 1157 STLSTMDRSVCSGASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSH 1216
T+ + +G + GD + + D AA PG +S
Sbjct: 556 GTVPS-----SAGILEQGPSPGDGSPPK-------PKDPVSAAVPAPG---RNNSQIASG 600
Query: 1217 HLMPCDTLARRRLARGRPDG----------EGAGRGGPRAPE----PPG--SASSSSQES 1260
P +L+ G+P + P P+ PPG SSS S
Sbjct: 601 QNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTS 660
Query: 1261 LRPPAAALASRPSRMEALRLRLRGTADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPL 1320
PP+ + P+R + + G + P P + S+ RR++ + SP+
Sbjct: 661 QHPPSLS-PKPPTRSPSPPTQHTG----------QPPGQPSAPSQLSAPRRYSSSL-SPI 708
Query: 1321 TDLNFNEWKELGGGGPPEPAGARAHSDNKDSG----LSSLESTKARAPSSAASQPPAPGD 1376
N + PP A H+ G ++ PS Q P P
Sbjct: 709 QAPNHPPPQ------PPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPS 762
Query: 1377 TGSLQSQPPRRSAASRL 1393
T L Q P A L
Sbjct: 763 TPPLGKQNPSLPAPQTL 779
Score = 31.2 bits (69), Expect = 7.3
Identities = 27/121 (22%), Positives = 44/121 (36%), Gaps = 7/121 (5%)
Query: 1038 PPGDPGSDSTTCSSAKSKGSWAPKKEP-YAREMLAISFISAVNRKRKKRREARGLGSSTD 1096
PPG P + S + + S +P + P + ++ K + + ++
Sbjct: 685 PPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSE 744
Query: 1097 DDSEQEAHKPGAGATAPGT----QERPQGPLPGAVAPEAPGRLSPPAA--PEERPAADTR 1150
EQ +H P T P T ++ P P P +A P P A P RP R
Sbjct: 745 HGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPR 804
Query: 1151 S 1151
+
Sbjct: 805 N 805
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 107 bits (267), Expect = 8e-23
Identities = 95/363 (26%), Positives = 160/363 (44%), Gaps = 21/363 (5%)
Query: 829 VAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQL--NRGPGDINLQDERWQDLNVISSL 886
V C + VE RG+ G+YR+ G N+ V L + P DI++ E W D I+S
Sbjct: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELW-DNKTITSG 456
Query: 887 LKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLK 946
LK++ R L EPL T + DFI A + +D R+ + L+ LP E L L+ HL
Sbjct: 457 LKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLV 516
Query: 947 TIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDE 1006
++ HS++N M NL ++FGPTL+R E+ + M+ ++ + +VE LI+H + F
Sbjct: 517 KVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMM-NIKFQNIVVEILIEHYEKIFHTA 575
Query: 1007 EDKGERTP-----VGDKEPQAVPNIEYLLPNIGRTVP-PGDPGSDSTTCSSAKSKGSWAP 1060
D P G + +A+ GR P +P SDS + S +
Sbjct: 576 PDPSIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIE 635
Query: 1061 KKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQE----AHKPGAGATAPGTQ 1116
++ E + + SA + R+K + + + + ++ P + + T+
Sbjct: 636 SLSSHSSEQNSTT-KSASCQPREKSGGIPWIATPSSSNGQKSLGLWTTSPESSSREDATK 694
Query: 1117 ERPQGPLPGAVAPEAPGRLSPPA-APEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRA 1175
+ + +PG +SPP ++ P +SG S S A G ++
Sbjct: 695 TDAESDCQSVASVTSPGDVSPPIDLVKKEPYG-----LSGLKRASASSLRSISAAEGNKS 749
Query: 1176 GAG 1178
+G
Sbjct: 750 YSG 752
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 106 bits (265), Expect = 1e-22
Identities = 83/361 (22%), Positives = 153/361 (42%), Gaps = 28/361 (7%)
Query: 800 KNKKAAPRAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSL 859
++K A AFG LEE + + L + AC ++ G++ G++R+ + + L
Sbjct: 241 QDKWAEKPAFGTPLEE-HLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKL 299
Query: 860 QEQLNRGPGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARER 919
+ L+ + DE + D + ++ LKS+ R+LPEPL T + Y ++ + ++D ++
Sbjct: 300 KAALDCSTSHL---DEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKK 356
Query: 920 MRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV-RTSEDNM 978
++ L + + LP + ++L+ L +A S+ NKM P N+A+V GP L+ +E +
Sbjct: 357 LQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTL 416
Query: 979 TDMVTHMPDR-YKIVETLIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTV 1037
+M ++E +IQH+DWFF +E + + P+ +
Sbjct: 417 AEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAF----------VPLTTPSSNHSF 466
Query: 1038 PPGDPGSDST-----TCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLG 1092
G+ T S A +G K+ P + + + A R + +
Sbjct: 467 HTGNDSDSGTLERKRPASMAVMEGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQP 526
Query: 1093 SSTDDDSEQEAHKP-GAGATAPGTQER------PQGPLPGAVAPEAPGRLSPPAAPEERP 1145
+ + +P A +P T R P P PG P PG S + P
Sbjct: 527 QAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPP 586
Query: 1146 A 1146
+
Sbjct: 587 S 587
Score = 31.2 bits (69), Expect = 7.3
Identities = 27/121 (22%), Positives = 44/121 (36%), Gaps = 7/121 (5%)
Query: 1038 PPGDPGSDSTTCSSAKSKGSWAPKKEP-YAREMLAISFISAVNRKRKKRREARGLGSSTD 1096
PPG P + S + + S +P + P + ++ K + + ++
Sbjct: 607 PPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSE 666
Query: 1097 DDSEQEAHKPGAGATAPGT----QERPQGPLPGAVAPEAPGRLSPPAA--PEERPAADTR 1150
EQ +H P T P T ++ P P P +A P P A P RP R
Sbjct: 667 HGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPR 726
Query: 1151 S 1151
+
Sbjct: 727 N 727
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,990,577
Number of Sequences: 37866
Number of extensions: 3857822
Number of successful extensions: 24583
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 258
Number of HSP's successfully gapped in prelim test: 975
Number of HSP's that attempted gapping in prelim test: 19276
Number of HSP's gapped (non-prelim): 6311
length of query: 1397
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1282
effective length of database: 13,892,928
effective search space: 17810733696
effective search space used: 17810733696
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.