Search of human proteins with 224177469

Search of human proteins with 224177469

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]
         (1290 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]       2640   0.0  
gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]       2636   0.0  
gi|238624099 SET domain, bifurcated 2 isoform b [Homo sapiens]        241   4e-63
gi|238624095 SET domain, bifurcated 2 isoform a [Homo sapiens]        241   4e-63
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is...   112   2e-24
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is...   112   2e-24
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...   108   3e-23
gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]      99   3e-20
gi|194306650 SET domain and mariner transposase fusion [Homo sap...    84   9e-16
gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]     79   2e-14
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    64   9e-10
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...    62   3e-09
gi|197313748 SET domain containing 2 [Homo sapiens]                    61   6e-09
gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [...    60   2e-08
gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]          58   5e-08
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    56   2e-07
gi|27477095 nuclear receptor binding SET domain protein 1 isofor...    56   3e-07
gi|19923586 nuclear receptor binding SET domain protein 1 isofor...    56   3e-07
gi|210032580 SET domain containing 1B [Homo sapiens]                   55   3e-07
gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo s...    54   1e-06
gi|55741677 SET domain containing 1A [Homo sapiens]                    53   2e-06
gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform...    52   4e-06
gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform...    52   4e-06
gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform...    52   4e-06
gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isofor...    52   4e-06
gi|19923202 enhancer of zeste homolog 1 [Homo sapiens]                 52   5e-06
gi|219802034 nuclear factor related to kappaB binding protein is...    50   1e-05
gi|23346420 nuclear factor related to kappaB binding protein iso...    50   1e-05
gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]                50   1e-05
gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]               49   2e-05

>gi|224177469 SET domain, bifurcated 1 isoform 2 [Homo sapiens]
          Length = 1290

 Score = 2640 bits (6844), Expect = 0.0
 Identities = 1290/1290 (100%), Positives = 1290/1290 (100%)

Query: 1    MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 60
            MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
Sbjct: 1    MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 60

Query: 61   LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 120
            LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
Sbjct: 61   LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 120

Query: 121  EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 180
            EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
Sbjct: 121  EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 180

Query: 181  HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 240
            HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
Sbjct: 181  HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 240

Query: 241  LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 300
            LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
Sbjct: 241  LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 300

Query: 301  YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 360
            YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
Sbjct: 301  YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 360

Query: 361  TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 420
            TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
Sbjct: 361  TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 420

Query: 421  NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL 480
            NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
Sbjct: 421  NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL 480

Query: 481  AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS 540
            AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
Sbjct: 481  AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS 540

Query: 541  ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL 600
            ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
Sbjct: 541  ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL 600

Query: 601  LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL 660
            LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
Sbjct: 601  LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL 660

Query: 661  DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN 720
            DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
Sbjct: 661  DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN 720

Query: 721  TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE 780
            TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
Sbjct: 721  TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE 780

Query: 781  CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD 840
            CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
Sbjct: 781  CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD 840

Query: 841  FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 900
            FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
Sbjct: 841  FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 900

Query: 901  SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP 960
            SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
Sbjct: 901  SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP 960

Query: 961  PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME 1020
            PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
Sbjct: 961  PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME 1020

Query: 1021 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT 1080
            AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
Sbjct: 1021 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT 1080

Query: 1081 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS 1140
            SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
Sbjct: 1081 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS 1140

Query: 1141 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF 1200
            EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
Sbjct: 1141 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF 1200

Query: 1201 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKIRAGTEL 1260
            YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKIRAGTEL
Sbjct: 1201 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKIRAGTEL 1260

Query: 1261 TWDYNYEVGSVEGKELLCCCGAIECRGRLL 1290
            TWDYNYEVGSVEGKELLCCCGAIECRGRLL
Sbjct: 1261 TWDYNYEVGSVEGKELLCCCGAIECRGRLL 1290


>gi|224177467 SET domain, bifurcated 1 isoform 1 [Homo sapiens]
          Length = 1291

 Score = 2636 bits (6832), Expect = 0.0
 Identities = 1290/1291 (99%), Positives = 1290/1291 (99%), Gaps = 1/1291 (0%)

Query: 1    MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 60
            MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ
Sbjct: 1    MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQ 60

Query: 61   LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 120
            LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT
Sbjct: 61   LAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPT 120

Query: 121  EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 180
            EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL
Sbjct: 121  EIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDL 180

Query: 181  HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 240
            HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS
Sbjct: 181  HKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGKS 240

Query: 241  LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 300
            LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG
Sbjct: 241  LLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNKLRFLIFFDDG 300

Query: 301  YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 360
            YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG
Sbjct: 301  YASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPNRPMVLLKSGQLIKTEWEG 360

Query: 361  TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 420
            TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP
Sbjct: 361  TWWKSRVEEVDGSLVRILFLDDKRCEWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRP 420

Query: 421  NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL 480
            NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL
Sbjct: 421  NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQL 480

Query: 481  AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS 540
            AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS
Sbjct: 481  AQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPS 540

Query: 541  ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL 600
            ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL
Sbjct: 541  ALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPL 600

Query: 601  LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL 660
            LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL
Sbjct: 601  LVPLLYDFRRMTARRRVNRKMGFHVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCL 660

Query: 661  DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN 720
            DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN
Sbjct: 661  DPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFIN 720

Query: 721  TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE 780
            TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE
Sbjct: 721  TGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYE 780

Query: 781  CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD 840
            CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD
Sbjct: 781  CNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDD 840

Query: 841  FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 900
            FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE
Sbjct: 841  FADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEE 900

Query: 901  SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP 960
            SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP
Sbjct: 901  SNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVP 960

Query: 961  PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME 1020
            PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME
Sbjct: 961  PSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRME 1020

Query: 1021 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT 1080
            AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT
Sbjct: 1021 AEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKT 1080

Query: 1081 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS 1140
            SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS
Sbjct: 1081 SMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGS 1140

Query: 1141 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF 1200
            EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF
Sbjct: 1141 EGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQF 1200

Query: 1201 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTE 1259
            YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK IRAGTE
Sbjct: 1201 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTE 1260

Query: 1260 LTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1290
            LTWDYNYEVGSVEGKELLCCCGAIECRGRLL
Sbjct: 1261 LTWDYNYEVGSVEGKELLCCCGAIECRGRLL 1291


>gi|238624099 SET domain, bifurcated 2 isoform b [Homo sapiens]
          Length = 707

 Score =  241 bits (614), Expect = 4e-63
 Identities = 121/268 (45%), Positives = 165/268 (61%), Gaps = 5/268 (1%)

Query: 571 LFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTP 630
           L Y  H CS  CL ++ P+     +G+NPL +P+   F+R  A+   +     HV YKTP
Sbjct: 128 LSYQSHDCSGACLMKM-PLN---LKGENPLQLPIKCHFQRRHAKTN-SHSSALHVSYKTP 182

Query: 631 CGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVP 690
           CG  LR ++E+ RYL ET C+FLF + F  + YV + R +   K     +DI+ G E VP
Sbjct: 183 CGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVP 242

Query: 691 LSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQA 750
           +S  NEID+   PQ  Y K   P      N    F   CDC +GC D +KCAC QLT + 
Sbjct: 243 ISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARN 302

Query: 751 TACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKT 810
              +P       +GY+YKRL+  +PTG+YEC+  CKC+  +C NR+VQHG QVRLQ+FKT
Sbjct: 303 AKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKT 362

Query: 811 QNKGWGIRCLDDIAKGSFVCIYAGKILT 838
           + KGWG+RCLDDI +G+FVCIY+G++L+
Sbjct: 363 EQKGWGVRCLDDIDRGTFVCIYSGRLLS 390



 Score =  112 bits (279), Expect = 3e-24
 Identities = 49/84 (58%), Positives = 65/84 (77%), Gaps = 1/84 (1%)

Query: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWDYNY 1266
            +++DA  EGN+GR+LNHSC PNL VQNVFV+TH+  FP VAFF ++ ++A TELTWDY Y
Sbjct: 624  FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGY 683

Query: 1267 EVGSVEGKELLCCCGAIECRGRLL 1290
            E G+V  KE+ C CG  +CR ++L
Sbjct: 684  EAGTVPEKEIFCQCGVNKCRKKIL 707


>gi|238624095 SET domain, bifurcated 2 isoform a [Homo sapiens]
          Length = 719

 Score =  241 bits (614), Expect = 4e-63
 Identities = 121/268 (45%), Positives = 165/268 (61%), Gaps = 5/268 (1%)

Query: 571 LFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGFHVIYKTP 630
           L Y  H CS  CL ++ P+     +G+NPL +P+   F+R  A+   +     HV YKTP
Sbjct: 140 LSYQSHDCSGACLMKM-PLN---LKGENPLQLPIKCHFQRRHAKTN-SHSSALHVSYKTP 194

Query: 631 CGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVP 690
           CG  LR ++E+ RYL ET C+FLF + F  + YV + R +   K     +DI+ G E VP
Sbjct: 195 CGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEVVSDVDISNGVESVP 254

Query: 691 LSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQA 750
           +S  NEID+   PQ  Y K   P      N    F   CDC +GC D +KCAC QLT + 
Sbjct: 255 ISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCIDITKCACLQLTARN 314

Query: 751 TACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKT 810
              +P       +GY+YKRL+  +PTG+YEC+  CKC+  +C NR+VQHG QVRLQ+FKT
Sbjct: 315 AKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRVVQHGPQVRLQVFKT 374

Query: 811 QNKGWGIRCLDDIAKGSFVCIYAGKILT 838
           + KGWG+RCLDDI +G+FVCIY+G++L+
Sbjct: 375 EQKGWGVRCLDDIDRGTFVCIYSGRLLS 402



 Score =  112 bits (279), Expect = 3e-24
 Identities = 49/84 (58%), Positives = 65/84 (77%), Gaps = 1/84 (1%)

Query: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWDYNY 1266
            +++DA  EGN+GR+LNHSC PNL VQNVFV+TH+  FP VAFF ++ ++A TELTWDY Y
Sbjct: 636  FLLDATKEGNVGRFLNHSCCPNLLVQNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGY 695

Query: 1267 EVGSVEGKELLCCCGAIECRGRLL 1290
            E G+V  KE+ C CG  +CR ++L
Sbjct: 696  EAGTVPEKEIFCQCGVNKCRKKIL 719


>gi|156142199 euchromatic histone-lysine N-methyltransferase 2 isoform
            b [Homo sapiens]
          Length = 1176

 Score =  112 bits (280), Expect = 2e-24
 Identities = 64/180 (35%), Positives = 97/180 (53%), Gaps = 14/180 (7%)

Query: 681  DITYGKEDVPLSCVNEIDTTPPPQ-VAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739
            D+  G E+VP+ CVN +D  P P+   Y  E      + I+     L  C C D C   S
Sbjct: 891  DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDC-SSS 949

Query: 740  KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799
             C C QL+I+      G  +      ++ ++E   P  ++ECN+ C C  N C NR+VQ 
Sbjct: 950  NCLCGQLSIRCWYDKDGRLLQ-----EFNKIE---PPLIFECNQACSCWRN-CKNRVVQS 1000

Query: 800  GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859
            G++VRLQL++T   GWG+R L  I +G+F+C Y G++++D  AD   +   D Y  +LD+
Sbjct: 1001 GIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD---VREDDSYLFDLDN 1057



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 3/86 (3%)

Query: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTEL 1260
            DGE  C  IDA+  GN+ R++NH C PN+    VF+   DLRFP +AFF+S+ IR G EL
Sbjct: 1059 DGEVYC--IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEEL 1116

Query: 1261 TWDYNYEVGSVEGKELLCCCGAIECR 1286
             +DY      ++ K   C CG+ +C+
Sbjct: 1117 GFDYGDRFWDIKSKYFTCQCGSEKCK 1142


>gi|156142197 euchromatic histone-lysine N-methyltransferase 2 isoform
            a [Homo sapiens]
          Length = 1210

 Score =  112 bits (280), Expect = 2e-24
 Identities = 64/180 (35%), Positives = 97/180 (53%), Gaps = 14/180 (7%)

Query: 681  DITYGKEDVPLSCVNEIDTTPPPQ-VAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739
            D+  G E+VP+ CVN +D  P P+   Y  E      + I+     L  C C D C   S
Sbjct: 925  DVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDC-SSS 983

Query: 740  KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799
             C C QL+I+      G  +      ++ ++E   P  ++ECN+ C C  N C NR+VQ 
Sbjct: 984  NCLCGQLSIRCWYDKDGRLLQ-----EFNKIE---PPLIFECNQACSCWRN-CKNRVVQS 1034

Query: 800  GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859
            G++VRLQL++T   GWG+R L  I +G+F+C Y G++++D  AD   +   D Y  +LD+
Sbjct: 1035 GIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEAD---VREDDSYLFDLDN 1091



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 38/86 (44%), Positives = 53/86 (61%), Gaps = 3/86 (3%)

Query: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTEL 1260
            DGE  C  IDA+  GN+ R++NH C PN+    VF+   DLRFP +AFF+S+ IR G EL
Sbjct: 1093 DGEVYC--IDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEEL 1150

Query: 1261 TWDYNYEVGSVEGKELLCCCGAIECR 1286
             +DY      ++ K   C CG+ +C+
Sbjct: 1151 GFDYGDRFWDIKSKYFTCQCGSEKCK 1176


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1 isoform
            1 [Homo sapiens]
          Length = 1298

 Score =  108 bits (271), Expect = 3e-23
 Identities = 65/180 (36%), Positives = 97/180 (53%), Gaps = 14/180 (7%)

Query: 681  DITYGKEDVPLSCVNEIDTTP-PPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739
            DI  G E +P+ CVN +D+ P P    Y  +      + I+     L  C C D C   S
Sbjct: 1013 DIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDC-SSS 1071

Query: 740  KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQH 799
             C C QL+++       G++ P    ++   E   P  ++ECN  C C  N C NR+VQ+
Sbjct: 1072 NCMCGQLSMRCWY-DKDGRLLP----EFNMAE---PPLIFECNHACSCWRN-CRNRVVQN 1122

Query: 800  GLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFANLDH 859
            GL+ RLQL++T++ GWG+R L DI  G+FVC Y G++++D  AD   +   D Y  +LD+
Sbjct: 1123 GLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEAD---VREEDSYLFDLDN 1179



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 39/86 (45%), Positives = 54/86 (62%), Gaps = 3/86 (3%)

Query: 1202 DGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTEL 1260
            DGE  C  IDA+  GN+ R++NH C PNL    VF+   DLRFP +AFF+++ I AG +L
Sbjct: 1181 DGEVYC--IDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQL 1238

Query: 1261 TWDYNYEVGSVEGKELLCCCGAIECR 1286
             +DY      ++GK   C CG+ +CR
Sbjct: 1239 GFDYGERFWDIKGKLFSCRCGSPKCR 1264


>gi|4507321 suppressor of variegation 3-9 homolog 1 [Homo sapiens]
          Length = 412

 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 62/181 (34%), Positives = 94/181 (51%), Gaps = 20/181 (11%)

Query: 695 NEIDTTPPPQV-AYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATAC 753
           NE+D   PP+   Y  E   G+G+ +N   +  VGC+C+D     +   C   ++   A 
Sbjct: 149 NEVDLDGPPRAFVYINEYRVGEGITLN---QVAVGCECQDCLWAPTGGCCPGASLHKFAY 205

Query: 754 TPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQN- 812
              GQ+         RL   LP  +YECN RC+C  + C NR+VQ G++  L +F+T + 
Sbjct: 206 NDQGQV---------RLRAGLP--IYECNSRCRCGYD-CPNRVVQKGIRYDLCIFRTDDG 253

Query: 813 KGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGL---EMGDEYFANLDHIESVENFKEG 869
           +GWG+R L+ I K SFV  Y G+I+T + A++ G      G  Y  +LD++E V      
Sbjct: 254 RGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAA 313

Query: 870 Y 870
           Y
Sbjct: 314 Y 314



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 46/120 (38%), Positives = 66/120 (55%), Gaps = 12/120 (10%)

Query: 1165 RGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGE-----------ESCYIIDAK 1213
            RG+ +++   I   S  M  V +  ++   +   Q YD +           E  Y +DA 
Sbjct: 254  RGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAA 313

Query: 1214 LEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWDYNYEVGSVE 1272
              GN+  ++NHSC PNL V NVF+D  D R P +AFFA++ IRAG ELT+DYN +V  V+
Sbjct: 314  YYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVD 373


>gi|194306650 SET domain and mariner transposase fusion [Homo
           sapiens]
          Length = 684

 Score = 84.0 bits (206), Expect = 9e-16
 Identities = 55/160 (34%), Positives = 77/160 (48%), Gaps = 16/160 (10%)

Query: 680 LDITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS 739
           LD+  G+E++P+          P Q  Y+ + + G G  I+       GC C        
Sbjct: 28  LDVACGQENLPVGAWPPGAAPAPFQ--YTPDHVVGPGADIDPTQITFPGCICVKTPCLPG 85

Query: 740 KCAC--HQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLV 797
            C+C  H       +C      +  SG +Y          V+ECN  C+C  + C NR+V
Sbjct: 86  TCSCLRHGENYDDNSCLR----DIGSGGKYAE-------PVFECNVLCRCSDH-CRNRVV 133

Query: 798 QHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 837
           Q GLQ   Q+FKT  KGWG+R L+ I KG FVC YAG++L
Sbjct: 134 QKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVL 173



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 15/97 (15%)

Query: 1201 YDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTE 1259
            Y+G+     +D    GN+GR+LNHSC PNL +  V +D+     P +A FA+K I    E
Sbjct: 201  YNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDS---MVPKLALFAAKDIVPEEE 257

Query: 1260 LTWDYN---YEVGSVEGKELL--------CCCGAIEC 1285
            L++DY+     +   E KE L        C CGA  C
Sbjct: 258  LSYDYSGRYLNLTVSEDKERLDHGKLRKPCYCGAKSC 294


>gi|13375930 suppressor of variegation 3-9 homolog 2 [Homo sapiens]
          Length = 350

 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 55/165 (33%), Positives = 78/165 (47%), Gaps = 25/165 (15%)

Query: 701 PPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKSKCACHQLTIQATACTPGGQIN 760
           PP    Y  E  P  G+ +     F  GC C D C  +  C      + A          
Sbjct: 105 PPSDFYYINEYKPAPGISLVNEATF--GCSCTD-CFFQKCCPAEAGVLLAY--------- 152

Query: 761 PNSGYQYKRLEECLPTG--VYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQN-KGWGI 817
            N   Q K     +P G  +YECN RC+C P+ C NR+VQ G Q  L +F+T N +GWG+
Sbjct: 153 -NKNQQIK-----IPPGTPIYECNSRCQCGPD-CPNRIVQKGTQYSLCIFRTSNGRGWGV 205

Query: 818 RCLDDIAKGSFVCIYAGKILTDDFADKEGL---EMGDEYFANLDH 859
           + L  I + SFV  Y G+++T + A++ G      G  Y  +LD+
Sbjct: 206 KTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDY 250



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 50/149 (33%), Positives = 73/149 (48%), Gaps = 24/149 (16%)

Query: 1165 RGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDGEESCYIIDAKLE--------- 1215
            RG+ +K+   I   S  M  V +  ++   +   QFYD +   Y+ D   E         
Sbjct: 201  RGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAA 260

Query: 1216 --GNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWDYNYE-VGSV 1271
              GN+  ++NHSC PNL V NVF+D  D R P +A F+++ I AG ELT+DY  +  G +
Sbjct: 261  RYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDI 320

Query: 1272 EGKEL-----------LCCCGAIECRGRL 1289
                +           +C CGA+ CRG L
Sbjct: 321  SSDSIDHSPAKKRVRTVCKCGAVTCRGYL 349


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 63.9 bits (154), Expect = 9e-10
 Identities = 68/313 (21%), Positives = 115/313 (36%), Gaps = 16/313 (5%)

Query: 838  TDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTED 897
            + D +D        +   + D  +S ++      SD+  SSDS   D  D  + NS   D
Sbjct: 668  SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD 727

Query: 898  PEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHI 957
               S+D S   N     D S SS     +    +    ++  S  +S  S   +      
Sbjct: 728  SSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN------ 781

Query: 958  PVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGS 1017
                S      +  S      N   S  S +S      +DSDS +S  ++   +     +
Sbjct: 782  ----SSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837

Query: 1018 RMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPP 1077
              ++  +S S     D  D   + + D+ + +  S  ++SS +   + S    E      
Sbjct: 838  SSDSSDSSDS----SDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893

Query: 1078 SKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTIS 1137
            S  S + S    +S  SN  D    S+S++S  ES  S   +    S+ + DS D    S
Sbjct: 894  SSDSSNSSDS-DSSDSSNSSDSSDSSNSSDS-SESSNSSDNSNSSDSSNSSDSSDSSDSS 951

Query: 1138 SGSEGDDFEDKKN 1150
            + S+  +  D  N
Sbjct: 952  NSSDSSNSSDSSN 964



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 61/280 (21%), Positives = 105/280 (37%), Gaps = 4/280 (1%)

Query: 872  SDAPCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQT 931
            SD+  SSDS   D     D +S   D  +S+D  S D+    +   +S    S  +   +
Sbjct: 561  SDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSS 620

Query: 932  RGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVS 991
              + ++  SE+ S DS              S      +  +S  +  +  +S  S +S S
Sbjct: 621  DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680

Query: 992  EGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKM 1051
                  SDS  S  ++   E        +++ + +S     +  D   +   D+ D +  
Sbjct: 681  SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740

Query: 1052 SVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGE 1111
            S  ++SS +   + S    +      S  S   S    +S  SN  D    S+S++S   
Sbjct: 741  SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSD---SSDSSNSSDSNDSSNSSDSSDS 797

Query: 1112 SGTSRKPTAGQTSATAVDSD-DIQTISSGSEGDDFEDKKN 1150
            S +S    +  +S ++  SD D    S  S   D  D  N
Sbjct: 798  SNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 75/370 (20%), Positives = 130/370 (35%), Gaps = 5/370 (1%)

Query: 840  DFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPE 899
            D +D        +   + D  ES  +      SD+  SSDSS  D  D  + +  +   +
Sbjct: 904  DSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS--DSSDSSNSSDSSNSSD 961

Query: 900  ESN-DDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIP 958
             SN  DSSD N     D S SS     +    +    ++  S  +S  S   D       
Sbjct: 962  SSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS 1021

Query: 959  VPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSR 1018
               S      +   S ++  +  +S  S +S S      SDS  S  +++  +       
Sbjct: 1022 SNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1081

Query: 1019 MEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPS 1078
             E+  +S S            +   D+ D +  S  ++SS +   + S    +      S
Sbjct: 1082 SESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS 1141

Query: 1079 KTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQT--SATAVDSDDIQTI 1136
              S   S    +S  S+  D    S S++S   S +S    +  +  S+ + DS D    
Sbjct: 1142 SDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1201

Query: 1137 SSGSEGDDFEDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKN 1196
            S  S+  D  D  + +       +  S+       +   +  S +  S D  +S+    +
Sbjct: 1202 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261

Query: 1197 TRQFYDGEES 1206
            T    D  +S
Sbjct: 1262 TSDSNDESDS 1271



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 68/295 (23%), Positives = 111/295 (37%), Gaps = 24/295 (8%)

Query: 858  DHIESVENFKEGYESDAPCSSDSS-GVDLKDQEDGNSGTEDPEESND-DSSDDNFCKDED 915
            D  +S  +      SD+  SSDSS   D  D  D ++ ++  + SN  DSSD +   D  
Sbjct: 745  DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSS 804

Query: 916  FSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPPSSEE 975
             S+ S   S ++   +    ++  S  +S  S+  D          S      +  S  +
Sbjct: 805  NSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSD----------SSDSSDSSDGSDSD 854

Query: 976  TPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEG 1035
            +     +S  S +S S      SDS  S  +NE        S   ++ + +S     D  
Sbjct: 855  SSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE--------SSNSSDSSDSSNSSDSDSS 906

Query: 1036 DIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSN 1095
            D   +   D+ D +  S  +ESS +   + S           S  S + S    +S  SN
Sbjct: 907  D--SSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964

Query: 1096 PDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDFEDKKN 1150
              D  +  S++    +S  S   +    S+ + DS D    S  S+  D  D  N
Sbjct: 965  SSD--SSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 69/319 (21%), Positives = 115/319 (36%), Gaps = 14/319 (4%)

Query: 838  TDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSS-------GVDLKDQED 890
            + D +D        +   + D  +S ++      SD+  SSDSS         D  D  D
Sbjct: 985  SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSD 1044

Query: 891  GNSGTEDPEESN-DDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHP 949
             +  ++  + SN  DSSD +   D   S+ S   S ++         N    + S DS  
Sbjct: 1045 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS-- 1102

Query: 950  PDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEG 1009
             D          S      N   S ++  +  +S  S +S S      SDS  S  +++ 
Sbjct: 1103 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDS 1162

Query: 1010 GEGRAGGSRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVK 1069
             +        ++  +S S            +   D+ D +  S  ++SS +   + S   
Sbjct: 1163 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1222

Query: 1070 PEGLRRPPSKTSMHQSRRLMASAQSNPDDVLTLS----SSTESEGESGTSRKPTAGQTSA 1125
             +      S  S   S    +S  SN  D    S    S+++S  ES +  K   G  + 
Sbjct: 1223 SDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNG 1282

Query: 1126 TAVDSDDIQTISSGSEGDD 1144
            +  DSD   + S+ S  DD
Sbjct: 1283 SDSDSDSEGSDSNHSTSDD 1301



 Score = 54.3 bits (129), Expect = 7e-07
 Identities = 60/311 (19%), Positives = 111/311 (35%), Gaps = 9/311 (2%)

Query: 838  TDDFADKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTED 897
            + D +D        +   + D  +S ++      SD+  SSDSS          +S + D
Sbjct: 973  SSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSD 1032

Query: 898  PEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHI 957
              +S+D S   +     D S SS     +    +    ++  S  +S  S   D      
Sbjct: 1033 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSD------ 1086

Query: 958  PVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGS 1017
                S      +   S ++  +  +S  S +S S      SDS  S  +++  +      
Sbjct: 1087 ---SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 1143

Query: 1018 RMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPP 1077
              ++ ++S S            +   D+ D +  S  ++SS +   + S    +      
Sbjct: 1144 SSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1203

Query: 1078 SKTSMHQSRRLMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTIS 1137
            S  S   S    +S  S+  D    S S ES   S +S    +  +S ++  SD   + S
Sbjct: 1204 SSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTS 1263

Query: 1138 SGSEGDDFEDK 1148
              ++  D + K
Sbjct: 1264 DSNDESDSQSK 1274



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 63/294 (21%), Positives = 108/294 (36%), Gaps = 4/294 (1%)

Query: 861  ESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDD-NFCKDEDFSTS 919
            ES  N     ESD   SS        D+   N    D + + DD SD  +   + D + +
Sbjct: 470  ESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGN 529

Query: 920  SVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPPSSEETPKN 979
                +    +   G+ ++  S++ S DS              S      +  SS+    +
Sbjct: 530  GNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD 589

Query: 980  KVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKA-STSGLGIKDEGDIK 1038
               S  S +S S      SDS  S  +++  + ++  S+ E++ + S S     D     
Sbjct: 590  SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSD 649

Query: 1039 QAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSNPDD 1098
             +   D+ D +  S  ++SS +   + S    +      S  S   S    +S  S+  D
Sbjct: 650  SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709

Query: 1099 VLTLSSSTESEGESGTSRKPTAGQT--SATAVDSDDIQTISSGSEGDDFEDKKN 1150
              +  SS  S   S  S    +  +  S+ + DS D    S+ S+  D  D  N
Sbjct: 710  SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSN 763



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 62/280 (22%), Positives = 113/280 (40%), Gaps = 10/280 (3%)

Query: 872  SDAPCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYATRRQT 931
            S+    S+S G D  D +D +   +DP  S++ + +D+   + D ++SS  R  A+    
Sbjct: 439  SNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSS--RGDASYNSD 496

Query: 932  RGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPPSSEETPKNKVASWLSCNSVS 991
               K+NG + + SK +   D               G N   +++  K+      S +S S
Sbjct: 497  E-SKDNG-NGSDSKGAEDDDSDSTSDTNNSDSNGNGNN--GNDDNDKSDSGKGKSDSSDS 552

Query: 992  EGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEGDIKQAKKEDTDDRNKM 1051
            +   + + S SS  ++         S  ++  + +S     D  D   +   D+ D +  
Sbjct: 553  DSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSD--SSNSSDSSDSSDS 610

Query: 1052 SVVTESSRNYGYNPSPVKPEG-LRRPPSKTSMHQSRRLMASAQSNPDDVLTLSSSTESEG 1110
            S  ++SS +        K E       SK+    S    +S  S+  D    S+S++S  
Sbjct: 611  SDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDS-S 669

Query: 1111 ESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDFEDKKN 1150
            +S  S   ++   S+ + DS D    S+ SE  D  D  +
Sbjct: 670  DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
            sapiens]
          Length = 2715

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 13/97 (13%)

Query: 1199 QFYDGEE-SCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAF 1249
            +FYDG+   CY        ++DA + GN  R++NHSC PN F + + V+        V F
Sbjct: 2619 KFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQK---HIVIF 2675

Query: 1250 FASKIRAGTELTWDYNYEVGSVEGKELLCCCGAIECR 1286
               +I  G ELT+DY + +     K L C CGA  CR
Sbjct: 2676 ALRRILRGEELTYDYKFPIEDASNK-LPCNCGAKRCR 2711



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 27/115 (23%), Positives = 50/115 (43%), Gaps = 6/115 (5%)

Query: 440 GTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSV 499
           G G + K    P P      P PP  P + + G+   E ++ Q+  ++ +++ +  P + 
Sbjct: 151 GRGRKHKTTPLPPPRLADVAPTPPKTP-ARKRGEEGTE-RMVQALTELLRRAQA--PQAP 206

Query: 500 GSGHSSPTSPALSENVSGGKPG--INQTYRSPLGSTASAPAPSALPAPPAPPVFH 552
            S    P++P  S     G+P     +  ++ + + A+   P   P PP  PV H
Sbjct: 207 RSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVPVKH 261



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 37/144 (25%), Positives = 52/144 (36%), Gaps = 6/144 (4%)

Query: 428 KGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQV 487
           K P V+ +  L    T   PV P +P   P+PP  P PP +P        S L +   + 
Sbjct: 553 KPPKVEVSPVLRPPITTSPPV-PQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRW 611

Query: 488 AKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQT-----YRSPLGSTASAPAPSAL 542
              +    P           SP  +   S  +P + +        + L    S   P  L
Sbjct: 612 TSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPL 671

Query: 543 PAPPAPPVFHGMLERAPAEPSYRA 566
            AP AP       + +PAEP  RA
Sbjct: 672 GAPEAPEPEPPPADDSPAEPEPRA 695



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 27/97 (27%), Positives = 36/97 (37%), Gaps = 14/97 (14%)

Query: 450 PPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQ-SRKQVAKKSTSFRPGSVGSGHSSPTS 508
           PP P +PP  P PP PP   +  +S      A  SRK+             G    +P+ 
Sbjct: 432 PPPPVSPPPLPSPPPPPAQEEQEESPPPVVPATCSRKR-------------GRPPLTPSQ 478

Query: 509 PALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAP 545
            A  E    G  G +    +P  +T   P  S   AP
Sbjct: 479 RAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAP 515



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 37/144 (25%), Positives = 49/144 (34%), Gaps = 33/144 (22%)

Query: 439  TGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRP-- 496
            T   T   P         PAP  PP   L P   D ++ S L+ +    A       P  
Sbjct: 1945 TSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQ 2004

Query: 497  ------GSVGSGH----------SSPTS------------PALSENVSGGKPGINQTYRS 528
                  G++GS H          SSPTS            P L+ + + G P I Q    
Sbjct: 2005 EEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGAPRIEQLDGV 2064

Query: 529  PLGSTASAPA---PSALPAPPAPP 549
              G+ + A A   P     PP+ P
Sbjct: 2065 DDGTDSEAEAVQQPRGQGTPPSGP 2088


>gi|197313748 SET domain containing 2 [Homo sapiens]
          Length = 2564

 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 37/96 (38%), Positives = 55/96 (57%), Gaps = 7/96 (7%)

Query: 1195 KNTRQFYDGEESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK- 1253
            KN   ++   ++  IIDA  +GN  R++NHSC PN   Q   V+   LR   V FF +K 
Sbjct: 1600 KNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVN-GQLR---VGFFTTKL 1655

Query: 1254 IRAGTELTWDYNYEVGSVEGKELLCCCGAIECRGRL 1289
            + +G+ELT+DY ++    E ++  C CG+  CRG L
Sbjct: 1656 VPSGSELTFDYQFQRYGKEAQK--CFCGSANCRGYL 1689



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 23/68 (33%), Positives = 38/68 (55%), Gaps = 2/68 (2%)

Query: 771  EECLPTGVY-ECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFV 829
            E+CL   +  EC+ RC  + + C+NR  Q      +++  T+ KGWG+R   D+   +FV
Sbjct: 1518 EDCLNRLLMIECSSRCP-NGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFV 1576

Query: 830  CIYAGKIL 837
              Y G++L
Sbjct: 1577 LEYCGEVL 1584


>gi|56550039 myeloid/lymphoid or mixed-lineage leukemia protein [Homo
            sapiens]
          Length = 3969

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 13/97 (13%)

Query: 1199 QFYDGEE-SCY--------IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAF 1249
            ++YD +   CY        ++DA + GN  R++NHSC PN + + + +D        V F
Sbjct: 3873 KYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQK---HIVIF 3929

Query: 1250 FASKIRAGTELTWDYNYEVGSVEGKELLCCCGAIECR 1286
               KI  G ELT+DY + +     K L C CGA +CR
Sbjct: 3930 AMRKIYRGEELTYDYKFPIEDASNK-LPCNCGAKKCR 3965


>gi|110349788 absent, small, or homeotic 1-like [Homo sapiens]
          Length = 2964

 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 35/84 (41%), Positives = 50/84 (59%), Gaps = 6/84 (7%)

Query: 1205 ESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWD 1263
            +S  +ID+   GN  R++NHSC PN  +Q   V+        +  +A K + AGTELT+D
Sbjct: 2199 DSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVN----GVYRIGLYALKDMPAGTELTYD 2254

Query: 1264 YNYEVGSVEGKELLCCCGAIECRG 1287
            YN+   +VE K+ LC CG  +CRG
Sbjct: 2255 YNFHSFNVE-KQQLCKCGFEKCRG 2277



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 49/202 (24%), Positives = 83/202 (41%), Gaps = 31/202 (15%)

Query: 770  LEECLPTGVY-ECNKR-CKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGS 827
            +++CL   ++ EC+   C C    C  R+ +H     L+ F+ + KGWGIR  + +  G 
Sbjct: 2105 VDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLERFRAEEKGWGIRTKEPLKAGQ 2164

Query: 828  FVCIYAGKILTDDFADKEGLEM----GDEYFANLDHIESVENFKEGYES-------DAPC 876
            F+  Y G+++++       +E      D Y  NLD    +++++ G E+       D  C
Sbjct: 2165 FIIEYLGEVVSEQEFRNRMIEQYHNHSDHYCLNLDSGMVIDSYRMGNEARFINHSCDPNC 2224

Query: 877  SSDSSGVD---------LKDQEDGNSGTEDPEESNDDSSDDNFCKDEDFSTSSVWRSYAT 927
                  V+         LKD   G   T D    + +      CK        +      
Sbjct: 2225 EMQKWSVNGVYRIGLYALKDMPAGTELTYDYNFHSFNVEKQQLCKCGFEKCRGIIGG--- 2281

Query: 928  RRQTRGQKENGLSETTSKDSHP 949
                + Q+ NGL  T+SK+S P
Sbjct: 2282 ----KSQRVNGL--TSSKNSQP 2297



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 38/153 (24%), Positives = 58/153 (37%), Gaps = 26/153 (16%)

Query: 986  SCNSVSEGGF------ADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGLGIKDEGD--I 1037
            S  S+S GGF      A SD H++  T+  G  R         K  T   G+    D  +
Sbjct: 1582 SSPSLSLGGFTPNSEPASSDEHTNLFTSAIGSCRVSNPNSSGRKKLTDSPGLFSAQDTSL 1641

Query: 1038 KQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSNPD 1097
             +  ++++   N+ +V T +    G  P+  KP              S+R   S   +P 
Sbjct: 1642 NRLHRKESLPSNERAVQTLA----GSQPTSDKP--------------SQRPSESTNCSPT 1683

Query: 1098 DVLTLSSSTESEGESGTSRKPTAGQTSATAVDS 1130
               + S ST S      SR P    +   +VDS
Sbjct: 1684 RKRSSSESTSSTVNGVPSRSPRLVASGDDSVDS 1716


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 30/79 (37%), Positives = 43/79 (54%), Gaps = 4/79 (5%)

Query: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKIRAGTELTWDYNYE 1267
            ++IDA L G   RY+NHSC+PN   + V  D  D     +   + +I  G ELT+DY ++
Sbjct: 5459 HVIDATLTGGPARYINHSCAPNCVAEVVTFDKED---KIIIISSRRIPKGEELTYDYQFD 5515

Query: 1268 VGSVEGKELLCCCGAIECR 1286
                + K + C CGA  CR
Sbjct: 5516 FEDDQHK-IPCHCGAWNCR 5533



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 44/158 (27%), Positives = 60/158 (37%), Gaps = 13/158 (8%)

Query: 447 PVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGHS-- 504
           P+ PP   +P +PP P A  LSP   DS +     +S      + +   P  V S  S  
Sbjct: 607 PLSPPPEESPLSPP-PEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPP 665

Query: 505 ---SPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAE 561
              SP SP   E+ +   P  ++    P  S  S P P   PA P P      L   P E
Sbjct: 666 PEESPLSPPPEESPTSPPPEASRLSPPPEDSPTS-PPPEDSPASPPP---EDSLMSLPLE 721

Query: 562 PSYRAPMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNP 599
            S   P+  L   P +C  +    + P   E +    P
Sbjct: 722 ES---PLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRP 756



 Score = 38.5 bits (88), Expect = 0.042
 Identities = 35/123 (28%), Positives = 44/123 (35%), Gaps = 7/123 (5%)

Query: 451 PQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRP---GSVGSGHSSPT 507
           P P   PA P P A  LS    +S L     +S      +S+ F P     +     SP 
Sbjct: 469 PPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEESPP 528

Query: 508 SPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYRAP 567
           SPAL   +S   P        P   +  +P P  LP  P P      L   P E     P
Sbjct: 529 SPALETPLS--PPPEASPLSPPFEESPLSPPPEELPTSPPPEA--SRLSPPPEESPMSPP 584

Query: 568 MEK 570
            E+
Sbjct: 585 PEE 587



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 31/117 (26%), Positives = 41/117 (35%), Gaps = 14/117 (11%)

Query: 447 PVEPPQPTAPPAPPFPPAP--------PLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGS 498
           P+ PP   +P +PPF  +P        P SP    S L     +S      + +   P  
Sbjct: 535 PLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPP 594

Query: 499 VGSG-----HSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPV 550
             S        SP SP   E+     P  ++    P  S  S P P   P  P P V
Sbjct: 595 EASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMS-PPPEESPMSPPPEV 650



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 38/138 (27%), Positives = 45/138 (32%), Gaps = 13/138 (9%)

Query: 435  TQDLTGTGTQFKPVEPPQPTAPPA-PPFPP---APPLSPQAGDSDLESQLAQSRKQVAKK 490
            +QD  G    + P+EP  PTAPP  PP+P    AP   P  G S                
Sbjct: 2173 SQDPFGLAPAY-PLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPP 2231

Query: 491  STSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPV 550
             T     S       P  P+L        PG+        G  AS P  S  P   +   
Sbjct: 2232 GTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVG-------GGKASEPLLSPPPFGESRKA 2284

Query: 551  FHGMLERAPA-EPSYRAP 567
                 E   A  PSY  P
Sbjct: 2285 LEVKKEELGASSPSYGPP 2302



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 38/148 (25%), Positives = 51/148 (34%), Gaps = 14/148 (9%)

Query: 426 RSKGPVVQYTQDLTGTGTQFKP-VEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSR 484
           +  GP+    + L   G Q +P +E P     P  P P   PLSP   +S        SR
Sbjct: 407 KEPGPLQCEAKPLGKAGVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASR 466

Query: 485 KQVAKKSTSFRPGSVGSGHS-----SPTSPALSENVSGGKPG---INQTYRSPLGSTASA 536
                +     P       S     SP SP   E+     P     +    SPL     +
Sbjct: 467 LSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEES 526

Query: 537 PAPSALPAPPAPPVFHGMLERAPAEPSY 564
           P   AL  P +PP      E +P  P +
Sbjct: 527 PPSPALETPLSPPP-----EASPLSPPF 549



 Score = 32.7 bits (73), Expect = 2.3
 Identities = 37/132 (28%), Positives = 47/132 (35%), Gaps = 8/132 (6%)

Query: 429  GPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVA 488
            GPV+Q  Q L G G      +            P    LSPQ     L++ L Q + Q +
Sbjct: 4176 GPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQ-QQQLQALLMQRQLQQS 4234

Query: 489  KKSTSFRPGSVGSGHSSPTSPALS-ENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPA 547
            +      P       +SP    L  +   GG PG       PL    + P P   P  PA
Sbjct: 4235 QAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPG---PQTGPLQELGAGPRPQGPPRLPA 4291

Query: 548  PPVFHGMLERAP 559
            PP   G L   P
Sbjct: 4292 PP---GALSTGP 4300



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 31/98 (31%), Positives = 39/98 (39%), Gaps = 27/98 (27%)

Query: 450  PPQPTAPPAPPFPPAPPLSP---QAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSP 506
            PP   +PPA P     PLSP     G SD E++L +   +                 S P
Sbjct: 1038 PPSQCSPPALPLSVPSPLSPIGKVVGVSD-EAELHEMETEKV---------------SEP 1081

Query: 507  TSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPA 544
              PAL  + +   P       SP+G   S PAPS  PA
Sbjct: 1082 ECPALEPSATSPLP-------SPMGD-LSCPAPSPAPA 1111



 Score = 32.0 bits (71), Expect = 3.9
 Identities = 38/137 (27%), Positives = 45/137 (32%), Gaps = 20/137 (14%)

Query: 446 KPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRP--------G 497
           +P   PQP  P     P  P LSPQA    L  Q  +       +     P         
Sbjct: 767 EPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSP 826

Query: 498 SVGSGHSSPTS--PALSENVSGG-------KPGINQTYRSPLGSTASAPAPSALP--APP 546
                H SP S  P LS             KP ++     P       PAP  LP   PP
Sbjct: 827 QPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPP 886

Query: 547 APPVFHGML-ERAPAEP 562
             P    +L E A +EP
Sbjct: 887 GEPSLSPLLGEPALSEP 903



 Score = 32.0 bits (71), Expect = 3.9
 Identities = 52/211 (24%), Positives = 67/211 (31%), Gaps = 46/211 (21%)

Query: 391  GSTRLEPMFSMKT--SSASALEKKQGQLRTR------PNMGAVRSKGPVVQYTQDLTGTG 442
            G    EP+ S      S  ALE K+ +L         PN+G V           D   +G
Sbjct: 2265 GGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFV-----------DSPSSG 2313

Query: 443  TQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTS----FRPGS 498
            T    +E   P    AP  P A  + PQ+    L  Q     + +A    S    FRPGS
Sbjct: 2314 THLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGS 2373

Query: 499  VGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERA 558
                ++ P                      PL      P P +  A P   +      R 
Sbjct: 2374 YTDPYAQP----------------------PLTPRPQPPPPESCCALPPRSLPSDPFSRV 2411

Query: 559  PAEP-SYRAPMEKLFYLPHVCSYTCLSRVRP 588
            PA P S  +    L   P      C S V P
Sbjct: 2412 PASPQSQSSSQSPLTPRPLSAEAFCPSPVTP 2442



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 32/127 (25%), Positives = 45/127 (35%), Gaps = 8/127 (6%)

Query: 451 PQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPA 510
           P+P  P   P P  P LSPQA +  L  Q  +       +     P + G  H SP    
Sbjct: 745 PRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGP-HLSPQPEE 803

Query: 511 LSENVSGGKPGINQTYRSPLGS-----TASAPAPSALPAPPAPPVFH--GMLERAPAEPS 563
           L  +    +P ++     P  S     +  +P        P P   H    LE+ P  P 
Sbjct: 804 LHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPR 863

Query: 564 YRAPMEK 570
              P E+
Sbjct: 864 PEKPPEE 870



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 32/119 (26%), Positives = 40/119 (33%), Gaps = 8/119 (6%)

Query: 450  PPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGH----SS 505
            PPQP A  +PP   AP +    G     + L+ S     K      PG    G       
Sbjct: 2107 PPQPGALGSPPPAAAPTIF--IGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLP 2164

Query: 506  PTSPAL--SENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEP 562
            P  PA   S++  G  P      R P       P PS   AP  PP+          +P
Sbjct: 2165 PQVPAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQP 2223


>gi|27477095 nuclear receptor binding SET domain protein 1 isoform a
            [Homo sapiens]
          Length = 2427

 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 37/82 (45%), Positives = 47/82 (57%), Gaps = 7/82 (8%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA-SKIRAGTELTWDYNYE 1267
            IIDA  +GN  R++NH C PN   Q   V+  D R   V  FA S I+AGTELT++YN E
Sbjct: 1737 IIDAGPKGNYARFMNHCCQPNCETQKWSVN-GDTR---VGLFALSDIKAGTELTFNYNLE 1792

Query: 1268 VGSVEGKELLCCCGAIECRGRL 1289
               +   + +C CGA  C G L
Sbjct: 1793 --CLGNGKTVCKCGAPNCSGFL 1812



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 19/63 (30%), Positives = 33/63 (52%)

Query: 778  VYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 837
            +YEC+         C N+         +++F+T  +GWG+R   DI KG FV  Y G+++
Sbjct: 1648 LYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELI 1707

Query: 838  TDD 840
             ++
Sbjct: 1708 DEE 1710


>gi|19923586 nuclear receptor binding SET domain protein 1 isoform b
            [Homo sapiens]
          Length = 2696

 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 37/82 (45%), Positives = 47/82 (57%), Gaps = 7/82 (8%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA-SKIRAGTELTWDYNYE 1267
            IIDA  +GN  R++NH C PN   Q   V+  D R   V  FA S I+AGTELT++YN E
Sbjct: 2006 IIDAGPKGNYARFMNHCCQPNCETQKWSVN-GDTR---VGLFALSDIKAGTELTFNYNLE 2061

Query: 1268 VGSVEGKELLCCCGAIECRGRL 1289
               +   + +C CGA  C G L
Sbjct: 2062 --CLGNGKTVCKCGAPNCSGFL 2081



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 19/63 (30%), Positives = 33/63 (52%)

Query: 778  VYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 837
            +YEC+         C N+         +++F+T  +GWG+R   DI KG FV  Y G+++
Sbjct: 1917 LYECHPTVCPAGGRCQNQCFSKRQYPEVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELI 1976

Query: 838  TDD 840
             ++
Sbjct: 1977 DEE 1979


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 6/81 (7%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKIRAGTELTWDYNYEV 1268
            IIDA   GN  R++NHSC+PN + + + V++       V +    I    E+T+DY +  
Sbjct: 1848 IIDATKCGNFARFINHSCNPNCYAKVITVESQK---KIVIYSKQHINVNEEITYDYKF-- 1902

Query: 1269 GSVEGKELLCCCGAIECRGRL 1289
              +E  ++ C CG+  CRG L
Sbjct: 1903 -PIEDVKIPCLCGSENCRGTL 1922



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 38/116 (32%), Positives = 52/116 (44%), Gaps = 12/116 (10%)

Query: 447  PVEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPGSVGSGHSSP 506
            P++PP P  PP PP PP+PP  P+  D+   S   +   +     T    GS+    S+ 
Sbjct: 1277 PLQPPLP--PPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTE 1334

Query: 507  TSPAL---SENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAP 559
            T PA       +SGG  G++ +     GS  S PAPS       P +  G L R P
Sbjct: 1335 TVPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPS-------PSLSSGGLPRTP 1383



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 14/25 (56%), Positives = 15/25 (60%)

Query: 445 FKPVEPPQPTAPPAPPFPPAPPLSP 469
           F P+ PP P  PP P FP  PPL P
Sbjct: 687 FPPLPPPPPPPPPQPGFPMPPPLPP 711



 Score = 34.3 bits (77), Expect = 0.79
 Identities = 14/25 (56%), Positives = 14/25 (56%)

Query: 447 PVEPPQPTAPPAPPFPPAPPLSPQA 471
           P  PPQP  P  PP PP PP  P A
Sbjct: 695 PPPPPQPGFPMPPPLPPPPPPPPPA 719



 Score = 31.6 bits (70), Expect = 5.1
 Identities = 12/20 (60%), Positives = 12/20 (60%)

Query: 450 PPQPTAPPAPPFPPAPPLSP 469
           PP P  PP PP PP PP  P
Sbjct: 682 PPPPGFPPLPPPPPPPPPQP 701



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 11/20 (55%), Positives = 12/20 (60%)

Query: 450  PPQPTAPPAPPFPPAPPLSP 469
            PP P  P  PP PP PP+ P
Sbjct: 1539 PPPPLPPQPPPPPPPPPVEP 1558


>gi|91718902 myeloid/lymphoid or mixed-lineage leukemia 3 [Homo
            sapiens]
          Length = 4911

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 4/79 (5%)

Query: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKIRAGTELTWDYNYE 1267
            ++IDA L G   RY+NHSC+PN   +   V T +     +   + +I+ G EL +DY ++
Sbjct: 4833 HVIDATLTGGPARYINHSCAPNCVAE---VVTFERGHKIIISSSRRIQKGEELCYDYKFD 4889

Query: 1268 VGSVEGKELLCCCGAIECR 1286
                + K + C CGA+ CR
Sbjct: 4890 FEDDQHK-IPCHCGAVNCR 4907



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 53/235 (22%), Positives = 75/235 (31%), Gaps = 62/235 (26%)

Query: 386  EWIYRGSTRLEPMFSMKTSSASALE--KKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGT 443
            EW +R   R +     K  +   LE  K + Q + +   G   S+  +VQ   D   +G 
Sbjct: 1750 EWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQFG---SQHLLVQSGSDTPSSGI 1806

Query: 444  QFKPVEPPQP-----------------TAPPAPPF----------PPAPPLSPQAGDSDL 476
            Q  P+ P QP                   PP+ P           P APP  P      +
Sbjct: 1807 Q-SPLTP-QPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPSRIPI 1864

Query: 477  ESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGINQTYRSPLGSTASA 536
            +  L+Q++         F PGS  S   SP  P                Y   +G+    
Sbjct: 1865 QDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDP----------------YAKMVGT---- 1904

Query: 537  PAPSALPAPPAPPVFHGMLERAPAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMRN 591
                    P  PPV H    R  A P            P   + T  +R  P+R+
Sbjct: 1905 --------PRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRD 1951



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 40/151 (26%), Positives = 57/151 (37%), Gaps = 29/151 (19%)

Query: 420  PNMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLSPQAGDS----- 474
            PN  +V+      Q   +L+GT  Q  PV P    A PA P P A    P   DS     
Sbjct: 3527 PNFSSVK------QGHGNLSGTSFQQSPVRPSFTPALPAAP-PVANSSLPCGQDSTITHG 3579

Query: 475  -----------DLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPTSPALSENVSGGKPGIN 523
                        L S +    K   K++   +         +P++P  S+  +   PGI+
Sbjct: 3580 HSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPH-SDITAPPTPGIS 3638

Query: 524  QTYRSPLGSTAS-----APAPSALPAPPAPP 549
            +T  +P  ST S     A   S  P  P+ P
Sbjct: 3639 ETTSTPAVSTPSELPQQADQESVEPVGPSTP 3669


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 6/81 (7%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKIRAGTELTWDYNYEV 1268
            IIDA   GNL R++NH C+PN + + + +++       V +    I    E+T+DY +  
Sbjct: 1632 IIDATKCGNLARFINHCCTPNCYAKVITIESQK---KIVIYSKQPIGVDEEITYDYKF-- 1686

Query: 1269 GSVEGKELLCCCGAIECRGRL 1289
              +E  ++ C CG   CRG L
Sbjct: 1687 -PLEDNKIPCLCGTESCRGSL 1706



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 68/286 (23%), Positives = 99/286 (34%), Gaps = 44/286 (15%)

Query: 874  APCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDDNF-CKDEDFSTSSVWRSYATRRQTR 932
            A  SS +S   L      +S +     S   SSD N+    E ++      SY  RR TR
Sbjct: 333  ATASSSASSSSLSSSSSSSSSSSS---SQFRSSDANYPAYYESWNRYQRHTSYPPRRATR 389

Query: 933  GQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVG-GCNPPSSEETPKNKVASWLSCNSVS 991
             +         + +  PP     ++P  PS P      PP+SE  P              
Sbjct: 390  EEPPGAPFAENTAERFPPSY-TSYLPPEPSRPTDQDYRPPASEAPPPEPPEP-----GGG 443

Query: 992  EGGFADSDSHSSFKTN--EGGEGRAGGSRMEAEKAST-----SGLGIKDEGDIKQAKKE- 1043
             GG   S      +T+       R+G    E    S      S L  + E  +K+ + + 
Sbjct: 444  GGGGGPSPEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKF 503

Query: 1044 -----DTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRRLMASAQSNPDD 1098
                 DT++  + S +   +R+ G         G   PP              A +N +D
Sbjct: 504  SFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPP-------------PAPANFED 550

Query: 1099 VLTLSSSTESEGESGTSRK-PTA-GQTSATAVDSDDIQTISSGSEG 1142
            V    S     GE G +R+ P A GQ  A+   S D   IS    G
Sbjct: 551  VAPTGS-----GEPGATRESPKANGQNQASPCSSGDDMEISDDDRG 591



 Score = 35.8 bits (81), Expect = 0.27
 Identities = 47/163 (28%), Positives = 59/163 (36%), Gaps = 39/163 (23%)

Query: 474 SDLESQLAQSRKQVAKKSTSFRPGSVGSGH---SSPTSPALSENVS---GGKPGIN---- 523
           SD E +   S   +  + T     S GSGH   + P +PA  E+V+    G+PG      
Sbjct: 508 SDTEEEEENSSMVLGARDTGSEVPS-GSGHGPCTPPPAPANFEDVAPTGSGEPGATRESP 566

Query: 524 ----QTYRSPL--------------GSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYR 565
               Q   SP               GS   AP P   P PP PP         P  P Y 
Sbjct: 567 KANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPP--------PPPPPPYL 618

Query: 566 APMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDF 608
           A +  L Y PH  +Y    R       +Y    P   P +YDF
Sbjct: 619 ASL-PLGYPPHQPAYLLPPRPDGPPPPEYPPPPP-PPPHIYDF 659



 Score = 35.0 bits (79), Expect = 0.46
 Identities = 32/136 (23%), Positives = 51/136 (37%), Gaps = 14/136 (10%)

Query: 843  DKEGLEMGDEYFANLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEESN 902
            D EG E   E  +  D  E  E  +E  + +    +     ++ D ED  S +       
Sbjct: 962  DSEGEEASQESSSEKDE-EDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLY 1020

Query: 903  DDSSDDNFCKDEDFSTSSVWRSYATRRQTRGQKENGLSETTSKD-------------SHP 949
             DS  +N    +  S+SS   S ++   +     +  SE++S+D             S P
Sbjct: 1021 ADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP 1080

Query: 950  PDLGPPHIPVPPSIPV 965
            P   P   P P  +PV
Sbjct: 1081 PREVPVPTPAPVEVPV 1096



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 17/48 (35%), Positives = 22/48 (45%)

Query: 421 NMGAVRSKGPVVQYTQDLTGTGTQFKPVEPPQPTAPPAPPFPPAPPLS 468
           N  +  S G  ++ + D  G      P  P QP  PP PP PP P L+
Sbjct: 572 NQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLA 619



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 12/24 (50%), Positives = 14/24 (58%)

Query: 450 PPQPTAPPAPPFPPAPPLSPQAGD 473
           PP+P  PP P +PP PP  P   D
Sbjct: 635 PPRPDGPPPPEYPPPPPPPPHIYD 658



 Score = 31.2 bits (69), Expect = 6.7
 Identities = 12/20 (60%), Positives = 12/20 (60%)

Query: 450 PPQPTAPPAPPFPPAPPLSP 469
           PP PT P  PP PP PP  P
Sbjct: 595 PPAPTPPQQPPPPPPPPPPP 614


>gi|19913358 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
            [Homo sapiens]
          Length = 1365

 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 7/82 (8%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA-SKIRAGTELTWDYNYE 1267
            IIDA  +GN  R++NHSC PN       V+  D R   V  FA   I AGTELT  +NY 
Sbjct: 1127 IIDAGPKGNYSRFMNHSCQPNCETLKWTVN-GDTR---VGLFAVCDIPAGTELT--FNYN 1180

Query: 1268 VGSVEGKELLCCCGAIECRGRL 1289
            +  +  ++ +C CGA  C G L
Sbjct: 1181 LDCLGNEKTVCRCGASNCSGFL 1202



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 18/63 (28%), Positives = 31/63 (49%)

Query: 778  VYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 837
            ++EC+ +       C N+          ++ KT  KGWG+    DI KG FV  Y G+++
Sbjct: 1038 MFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELI 1097

Query: 838  TDD 840
             ++
Sbjct: 1098 DEE 1100


>gi|19913350 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
            [Homo sapiens]
          Length = 1365

 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 7/82 (8%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA-SKIRAGTELTWDYNYE 1267
            IIDA  +GN  R++NHSC PN       V+  D R   V  FA   I AGTELT  +NY 
Sbjct: 1127 IIDAGPKGNYSRFMNHSCQPNCETLKWTVN-GDTR---VGLFAVCDIPAGTELT--FNYN 1180

Query: 1268 VGSVEGKELLCCCGAIECRGRL 1289
            +  +  ++ +C CGA  C G L
Sbjct: 1181 LDCLGNEKTVCRCGASNCSGFL 1202



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 18/63 (28%), Positives = 31/63 (49%)

Query: 778  VYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 837
            ++EC+ +       C N+          ++ KT  KGWG+    DI KG FV  Y G+++
Sbjct: 1038 MFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELI 1097

Query: 838  TDD 840
             ++
Sbjct: 1098 DEE 1100


>gi|19913348 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
            [Homo sapiens]
          Length = 1365

 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 7/82 (8%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA-SKIRAGTELTWDYNYE 1267
            IIDA  +GN  R++NHSC PN       V+  D R   V  FA   I AGTELT  +NY 
Sbjct: 1127 IIDAGPKGNYSRFMNHSCQPNCETLKWTVN-GDTR---VGLFAVCDIPAGTELT--FNYN 1180

Query: 1268 VGSVEGKELLCCCGAIECRGRL 1289
            +  +  ++ +C CGA  C G L
Sbjct: 1181 LDCLGNEKTVCRCGASNCSGFL 1202



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 18/63 (28%), Positives = 31/63 (49%)

Query: 778  VYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 837
            ++EC+ +       C N+          ++ KT  KGWG+    DI KG FV  Y G+++
Sbjct: 1038 MFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELI 1097

Query: 838  TDD 840
             ++
Sbjct: 1098 DEE 1100


>gi|109633019 Wolf-Hirschhorn syndrome candidate 1 protein isoform 1
            [Homo sapiens]
          Length = 1365

 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 35/82 (42%), Positives = 45/82 (54%), Gaps = 7/82 (8%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA-SKIRAGTELTWDYNYE 1267
            IIDA  +GN  R++NHSC PN       V+  D R   V  FA   I AGTELT  +NY 
Sbjct: 1127 IIDAGPKGNYSRFMNHSCQPNCETLKWTVN-GDTR---VGLFAVCDIPAGTELT--FNYN 1180

Query: 1268 VGSVEGKELLCCCGAIECRGRL 1289
            +  +  ++ +C CGA  C G L
Sbjct: 1181 LDCLGNEKTVCRCGASNCSGFL 1202



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 18/63 (28%), Positives = 31/63 (49%)

Query: 778  VYECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKIL 837
            ++EC+ +       C N+          ++ KT  KGWG+    DI KG FV  Y G+++
Sbjct: 1038 MFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELI 1097

Query: 838  TDD 840
             ++
Sbjct: 1098 DEE 1100


>gi|19923202 enhancer of zeste homolog 1 [Homo sapiens]
          Length = 747

 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 35/129 (27%), Positives = 55/129 (42%), Gaps = 23/129 (17%)

Query: 728 GCDCKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKC 787
           GC CK  C  K +C C+   +    C P               + CL  G  E      C
Sbjct: 560 GCRCKTQCNTK-QCPCY---LAVRECDP---------------DLCLTCGASE---HWDC 597

Query: 788 DPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGL 847
               C N  +Q GL+  L L  +   GWG    + + K  F+  Y G++++ D AD+ G 
Sbjct: 598 KVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRG- 656

Query: 848 EMGDEYFAN 856
           ++ D+Y ++
Sbjct: 657 KVYDKYMSS 665



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 24/60 (40%), Positives = 37/60 (61%), Gaps = 5/60 (8%)

Query: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWDYNY 1266
            +++DA  +GN  R+ NHS +PN + + V V+  D R   +  FA + I+AG EL +DY Y
Sbjct: 674  FVVDATRKGNKIRFANHSVNPNCYAKVVMVN-GDHR---IGIFAKRAIQAGEELFFDYRY 729


>gi|219802034 nuclear factor related to kappaB binding protein
           isoform 1 [Homo sapiens]
          Length = 1299

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 64/241 (26%), Positives = 90/241 (37%), Gaps = 30/241 (12%)

Query: 347 LLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDK-------RCEWIYRGSTRLEPMF 399
           LLK  Q +  +   T   +    V G+L R+ +  D        R  WIY    R E  F
Sbjct: 603 LLKDSQFLAPDVTSTQVNT---VVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEF 659

Query: 400 SMKTSSASALEKKQGQLRTRPNMGA------------VRSKGPVVQYTQDLTGTGTQFKP 447
                + +A  K +  L+ +P   +            V S GP  Q    L+ +     P
Sbjct: 660 ERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTP 719

Query: 448 VEPPQPTAP--PAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPG-----SVG 500
           V P  PT P  PA P  P P  +         S+ A+S   V   S+   P      S  
Sbjct: 720 VTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPA 779

Query: 501 SGHSSPTSPALSENVS-GGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAP 559
           S  ++P+S A +  VS  G  G++Q       S  + P  S  PA   P +  G   R P
Sbjct: 780 SSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVP 839

Query: 560 A 560
           A
Sbjct: 840 A 840


>gi|23346420 nuclear factor related to kappaB binding protein
           isoform 2 [Homo sapiens]
          Length = 1324

 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 64/241 (26%), Positives = 90/241 (37%), Gaps = 30/241 (12%)

Query: 347 LLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDK-------RCEWIYRGSTRLEPMF 399
           LLK  Q +  +   T   +    V G+L R+ +  D        R  WIY    R E  F
Sbjct: 628 LLKDSQFLAPDVTSTQVNT---VVSGALDRLHYEKDPCVKYDIGRKLWIYLHRDRSEEEF 684

Query: 400 SMKTSSASALEKKQGQLRTRPNMGA------------VRSKGPVVQYTQDLTGTGTQFKP 447
                + +A  K +  L+ +P   +            V S GP  Q    L+ +     P
Sbjct: 685 ERIHQAQAAAAKARKALQQKPKPPSKVKSSSKESSIKVLSSGPSEQSQMSLSDSSMPPTP 744

Query: 448 VEPPQPTAP--PAPPFPPAPPLSPQAGDSDLESQLAQSRKQVAKKSTSFRPG-----SVG 500
           V P  PT P  PA P  P P  +         S+ A+S   V   S+   P      S  
Sbjct: 745 VTPVTPTTPALPAIPISPPPVSAVNKSGPSTVSEPAKSSSGVLLVSSPTMPHLGTMLSPA 804

Query: 501 SGHSSPTSPALSENVS-GGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAP 559
           S  ++P+S A +  VS  G  G++Q       S  + P  S  PA   P +  G   R P
Sbjct: 805 SSQTAPSSQAAARVVSHSGSAGLSQVRVVAQPSLPAVPQQSGGPAQTLPQMPAGPQIRVP 864

Query: 560 A 560
           A
Sbjct: 865 A 865


>gi|13699811 WHSC1L1 protein isoform long [Homo sapiens]
          Length = 1437

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 35/82 (42%), Positives = 44/82 (53%), Gaps = 7/82 (8%)

Query: 1209 IIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFA-SKIRAGTELTWDYNYE 1267
            IIDA  +GN  R++NHSC+PN   Q   V+  D+R   V  FA   I AG ELT  +NY 
Sbjct: 1209 IIDAGPKGNYSRFMNHSCNPNCETQKWTVN-GDVR---VGLFALCDIPAGMELT--FNYN 1262

Query: 1268 VGSVEGKELLCCCGAIECRGRL 1289
            +  +      C CGA  C G L
Sbjct: 1263 LDCLGNGRTECHCGADNCSGFL 1284



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 22/70 (31%), Positives = 37/70 (52%), Gaps = 1/70 (1%)

Query: 772  ECLPTGV-YECNKRCKCDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVC 830
            ECL   + YEC+ +     + C N+     L    ++ KT+ +GWG+R    I KG FV 
Sbjct: 1113 ECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVN 1172

Query: 831  IYAGKILTDD 840
             Y G+++ ++
Sbjct: 1173 EYVGELIDEE 1182



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 25/96 (26%), Positives = 41/96 (42%), Gaps = 8/96 (8%)

Query: 395 LEPMFSMKTSSASALEK--KQGQLRTRPN-----MGAVRSKGPVVQYTQDLTGTGTQFKP 447
           L P+ +   SS S  E   K       PN      GAVR+  P   Y  ++  T    + 
Sbjct: 66  LPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPH-EI 124

Query: 448 VEPPQPTAPPAPPFPPAPPLSPQAGDSDLESQLAQS 483
           +E P P  PP PP  P   +  + G  +++ ++ ++
Sbjct: 125 LEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKT 160


>gi|23510384 enhancer of zeste 2 isoform b [Homo sapiens]
          Length = 707

 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 35/128 (27%), Positives = 53/128 (41%), Gaps = 8/128 (6%)

Query: 731 CKDGCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPN 790
           C+  C+  S+C       +   C    Q N      Y  + EC P     C      D  
Sbjct: 504 CEKFCQCSSECQN-----RFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSK 558

Query: 791 --MCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLE 848
              C N  +Q G +  L L  +   GWGI   D + K  F+  Y G+I++ D AD+ G +
Sbjct: 559 NVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRG-K 617

Query: 849 MGDEYFAN 856
           + D+Y  +
Sbjct: 618 VYDKYMCS 625



 Score = 38.5 bits (88), Expect = 0.042
 Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 5/60 (8%)

Query: 1208 YIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASK-IRAGTELTWDYNY 1266
            +++DA  +GN  R+ NHS +PN + + + V+  D R   +  FA + I+ G EL +DY Y
Sbjct: 634  FVVDATRKGNKIRFANHSVNPNCYAKVMMVN-GDHR---IGIFAKRAIQTGEELFFDYRY 689


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,318,087
Number of Sequences: 37866
Number of extensions: 2917669
Number of successful extensions: 28505
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 230
Number of HSP's successfully gapped in prelim test: 902
Number of HSP's that attempted gapping in prelim test: 18198
Number of HSP's gapped (non-prelim): 7823
length of query: 1290
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1176
effective length of database: 13,930,794
effective search space: 16382613744
effective search space used: 16382613744
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.