Guide to the Human Genome
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Search of human proteins with 223890219

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|223890219 RNA binding motif protein, X-linked-like 3 [Homo
sapiens]
         (1067 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|223890219 RNA binding motif protein, X-linked-like 3 [Homo sa...  2290   0.0  
gi|153252068 testes-specific heterogenous nuclear ribonucleoprot...   393   e-109
gi|56699409 RNA binding motif protein, X-linked [Homo sapiens]        305   2e-82
gi|242117971 RNA binding motif protein, X-linked-like 1 [Homo sa...   296   7e-80
gi|21361809 RNA binding motif protein, X-linked-like 1 [Homo sap...   296   7e-80
gi|56090533 RNA binding motif protein, Y-linked, family 1, membe...   182   1e-45
gi|4826974 RNA binding motif protein, Y-linked, family 1, member...   182   2e-45
gi|56090527 RNA binding motif protein, Y-linked, family 1, membe...   181   3e-45
gi|54633344 RNA binding motif protein, Y-linked, family 1, membe...   181   4e-45
gi|34303937 RNA binding motif protein, Y-linked, family 1, membe...   179   2e-44
gi|56090529 RNA binding motif protein, Y-linked, family 1, membe...   179   2e-44
gi|57864582 hornerin [Homo sapiens]                                   174   4e-43
gi|239752336 PREDICTED: similar to RNA binding motif protein, X-...   147   7e-35
gi|239746849 PREDICTED: hypothetical protein XP_002343863 [Homo ...   147   7e-35
gi|60097902 filaggrin [Homo sapiens]                                  145   3e-34
gi|62122917 filaggrin family member 2 [Homo sapiens]                  116   1e-25
gi|239757825 PREDICTED: hypothetical protein XP_002346350 [Homo ...    98   4e-20
gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens]          92   3e-18
gi|5803137 RNA binding motif protein 3 [Homo sapiens]                  91   6e-18
gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens]           91   8e-18
gi|4502847 cold inducible RNA binding protein [Homo sapiens]           89   2e-17
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    89   2e-17
gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma...    74   6e-13
gi|55956899 keratin 9 [Homo sapiens]                                   74   1e-12
gi|14043070 heterogeneous nuclear ribonucleoprotein A1 isoform b...    73   1e-12
gi|171916097 repetin [Homo sapiens]                                    73   2e-12
gi|109255251 loricrin [Homo sapiens]                                   72   4e-12
gi|9558733 transformer-2 alpha [Homo sapiens]                          71   6e-12
gi|212549553 interleukin enhancer binding factor 3 isoform d [Ho...    70   1e-11
gi|24234750 interleukin enhancer binding factor 3 isoform a [Hom...    70   1e-11

>gi|223890219 RNA binding motif protein, X-linked-like 3 [Homo
            sapiens]
          Length = 1067

 Score = 2290 bits (5935), Expect = 0.0
 Identities = 1067/1067 (100%), Positives = 1067/1067 (100%)

Query: 1    MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
            MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA
Sbjct: 1    MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60

Query: 61   DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQR 120
            DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQR
Sbjct: 61   DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQR 120

Query: 121  PPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRG 180
            PPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRG
Sbjct: 121  PPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRG 180

Query: 181  KAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVR 240
            KAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVR
Sbjct: 181  KAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVR 240

Query: 241  EPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSY 300
            EPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSY
Sbjct: 241  EPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSY 300

Query: 301  REPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRD 360
            REPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRD
Sbjct: 301  REPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRD 360

Query: 361  HSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGE 420
            HSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGE
Sbjct: 361  HSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGE 420

Query: 421  GRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLD 480
            GRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLD
Sbjct: 421  GRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLD 480

Query: 481  ANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNS 540
            ANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNS
Sbjct: 481  ANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNS 540

Query: 541  YGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLD 600
            YGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLD
Sbjct: 541  YGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLD 600

Query: 601  ANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQS 660
            ANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQS
Sbjct: 601  ANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQS 660

Query: 661  NCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANS 720
            NCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANS
Sbjct: 661  NCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANS 720

Query: 721  GGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYE 780
            GGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYE
Sbjct: 721  GGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYE 780

Query: 781  EYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSG 840
            EYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSG
Sbjct: 781  EYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSG 840

Query: 841  GRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNS 900
            GRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNS
Sbjct: 841  GRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNS 900

Query: 901  YGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAH 960
            YGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAH
Sbjct: 901  YGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAH 960

Query: 961  SGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGR 1020
            SGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGR
Sbjct: 961  SGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGR 1020

Query: 1021 PDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
            PDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY
Sbjct: 1021 PDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067


>gi|153252068 testes-specific heterogenous nuclear ribonucleoprotein
           G-T [Homo sapiens]
          Length = 392

 Score =  393 bits (1009), Expect = e-109
 Identities = 236/437 (54%), Positives = 265/437 (60%), Gaps = 54/437 (12%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EADRP KLFIGGLNL+TDEKAL+AEFGKYG I++V LMKDR+TNKSRGFAFVTFESPA
Sbjct: 1   MVEADRPGKLFIGGLNLETDEKALEAEFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPA 60

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQR 120
           DAKAAARDMNGK LDGKAI VAQ  KPAF+SSR  PP P S  R RF   TRGGG  P+R
Sbjct: 61  DAKAAARDMNGKSLDGKAIKVAQATKPAFESSRRGPPPPRSRGRPRFLRGTRGGGGGPRR 120

Query: 121 PPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRG 180
            PS+G PDD  GY   FDL P RAPMP KRGPPPR    PP KRA PS  A S G GMRG
Sbjct: 121 SPSRGGPDDDGGYTADFDLRPSRAPMPMKRGPPPRR-VGPPPKRAAPSGPARSSGGGMRG 179

Query: 181 KAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVR 240
           +A  V G+DGYSG  PRR   PP +               +  +      +DGYS    R
Sbjct: 180 RALAVRGRDGYSG-PPRREPLPPRRDPY------------LGPRDEGYSSRDGYSSRDYR 226

Query: 241 EPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSY 300
           E       P  F P+  +Y+ R YGHSSV D  PLRG  +++GY GRD +Y DH S+GS+
Sbjct: 227 E-------PRGFAPSPGEYTHRDYGHSSVRDDCPLRGYSDRDGYGGRDRDYGDHLSRGSH 279

Query: 301 REPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRD 360
           REP +SYG   GAAP  GTPPSYGGG RYEEY+G SPDA                     
Sbjct: 280 REPFESYGELRGAAPGRGTPPSYGGGGRYEEYRGYSPDA--------------------- 318

Query: 361 HSPKAYSGGRSSSSNGYSRSDRY--GEEGCYEEYRGRSPDAHSG---GRNSSSNSYGQSH 415
                YSGGR S S+ Y RSDRY  G        RG S     G    R+S S S  +  
Sbjct: 319 -----YSGGRDSYSSSYGRSDRYSRGRHRVGRPDRGLSLSMERGCPPQRDSYSRSGCRVP 373

Query: 416 HYGGE--GRYEEYRGRS 430
             GG   GR E   GRS
Sbjct: 374 RGGGRLGGRLERGGGRS 390



 Score =  162 bits (411), Expect = 1e-39
 Identities = 109/231 (47%), Positives = 118/231 (51%), Gaps = 26/231 (11%)

Query: 854  RYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSF----SNSYGRSDHYGR 909
            R  GGG     RGR+     R    D +SG    E     RD +       Y   D Y  
Sbjct: 171  RSSGGG----MRGRALAVRGR----DGYSGPPRREPLPPRRDPYLGPRDEGYSSRDGYSS 222

Query: 910  GGCYEEYQG--RSPNAYG----GGRGLNSSNNSHGRSHRYGGGGRYEEY-----RGP--S 956
               Y E +G   SP  Y     G   +       G S R G GGR  +Y     RG    
Sbjct: 223  RD-YREPRGFAPSPGEYTHRDYGHSSVRDDCPLRGYSDRDGYGGRDRDYGDHLSRGSHRE 281

Query: 957  PDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRD 1016
            P    G    +    G    YGGGG YEEY+G  PDAYSG  D  S+SYGRSDRYSRGR 
Sbjct: 282  PFESYGELRGAAPGRGTPPSYGGGGRYEEYRGYSPDAYSGGRDSYSSSYGRSDRYSRGRH 341

Query: 1017 RVGRPDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
            RVGRPDRGL L ME G PP  DSYSRSGCRVPRGGGR GGR ERG GRSRY
Sbjct: 342  RVGRPDRGLSLSMERGCPPQRDSYSRSGCRVPRGGGRLGGRLERGGGRSRY 392



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 112/401 (27%), Positives = 133/401 (33%), Gaps = 101/401 (25%)

Query: 175 GCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGY 234
           G  + GKA  V+     +    RR   PP  R  PR      GG G P ++P+  G D  
Sbjct: 71  GKSLDGKAIKVAQATKPAFESSRRGPPPPRSRGRPRFLRGTRGGGGGPRRSPSRGGPD-- 128

Query: 235 SGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDH 294
                        D G              G+++  D RP R                  
Sbjct: 129 -------------DDG--------------GYTADFDLRPSRA----------------- 144

Query: 295 PSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLP 354
           P       P +  G P   A   G   S GGG R         D  S     E LP    
Sbjct: 145 PMPMKRGPPPRRVGPPPKRAAPSGPARSSGGGMRGRALAVRGRDGYSGPPRREPLPP--- 201

Query: 355 DAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPD---------AHSGGRN 405
               RD     Y G R     GYS  D Y     Y E RG +P           HS  R+
Sbjct: 202 ---RRD----PYLGPRDE---GYSSRDGYSSRD-YREPRGFAPSPGEYTHRDYGHSSVRD 250

Query: 406 SSS-NSYGQSHHYGGEGR-YEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSD 463
                 Y     YGG  R Y ++  R      G       S G    A  G     S+  
Sbjct: 251 DCPLRGYSDRDGYGGRDRDYGDHLSR------GSHREPFESYGELRGAAPGRGTPPSY-- 302

Query: 464 CCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSS----WSDRYGVGGHY--EENRGHS 517
             GGGGRYEEY+         G SP+AYSGG D+ S     SDRY  G H     +RG S
Sbjct: 303 --GGGGRYEEYR---------GYSPDAYSGGRDSYSSSYGRSDRYSRGRHRVGRPDRGLS 351

Query: 518 LDANSG---GRSPDTHSGGH--SSSSNSYGQSHRYGGEGRY 553
           L    G    R   + SG           G+  R GG  RY
Sbjct: 352 LSMERGCPPQRDSYSRSGCRVPRGGGRLGGRLERGGGRSRY 392



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 101/312 (32%), Positives = 111/312 (35%), Gaps = 105/312 (33%)

Query: 657 SGQSNCYGGG--GRYEEYRGRLLDANSGG--RSP-----DAYSGGHDSSSQSNRYGGGGR 707
           SG +   GGG  GR    RGR  D  SG   R P     D Y G  D    S        
Sbjct: 167 SGPARSSGGGMRGRALAVRGR--DGYSGPPRREPLPPRRDPYLGPRDEGYSSRDGYSSRD 224

Query: 708 YEEYRGHSLDANSGGRSPDTYSR---GHDS-------SSQSDHYGGGGRSLDANSSGRLP 757
           Y E RG +        SP  Y+    GH S          SD  G GGR  D        
Sbjct: 225 YREPRGFA-------PSPGEYTHRDYGHSSVRDDCPLRGYSDRDGYGGRDRDY------- 270

Query: 758 DAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGR 817
                G   S  SHR      +E Y G    A  G  +P +Y GG             GR
Sbjct: 271 -----GDHLSRGSHREP----FESY-GELRGAAPGRGTPPSYGGG-------------GR 307

Query: 818 YEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRS 877
           YEE RG+S         P+AYSGGRDS S+SY RS RY  G H     GR      RG S
Sbjct: 308 YEEYRGYS---------PDAYSGGRDSYSSSYGRSDRYSRGRHRV---GRP----DRGLS 351

Query: 878 PDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSH 937
                G                   + D Y R GC      R P   GGGR         
Sbjct: 352 LSMERG----------------CPPQRDSYSRSGC------RVPR--GGGR-------LG 380

Query: 938 GRSHRYGGGGRY 949
           GR  R GG  RY
Sbjct: 381 GRLERGGGRSRY 392



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 80/232 (34%), Positives = 94/232 (40%), Gaps = 41/232 (17%)

Query: 584 RYGGGGCYEEYRGRSL-----DANSGG--RSP-----NAYSGGHDSSSWSHRYGGGGR-Y 630
           R  GGG     RGR+L     D  SG   R P     + Y G  D   +S R G   R Y
Sbjct: 171 RSSGGGM----RGRALAVRGRDGYSGPPRREPLPPRRDPYLGPRDEG-YSSRDGYSSRDY 225

Query: 631 EEYRGRSLDANSGGRSPDAYSGGHDSS---GQSNCYGGGGRYEEYRGRLLDANSGGRSP- 686
            E RG +            +S   D     G S+  G GGR  +Y   L  +    R P 
Sbjct: 226 REPRGFAPSPGEYTHRDYGHSSVRDDCPLRGYSDRDGYGGRDRDYGDHL--SRGSHREPF 283

Query: 687 DAYS---GGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGG 743
           ++Y    G          YGGGGRYEEYRG+S DA SGGR  D+YS    S  +SD Y  
Sbjct: 284 ESYGELRGAAPGRGTPPSYGGGGRYEEYRGYSPDAYSGGR--DSYS---SSYGRSDRYSR 338

Query: 744 G-------GRSLDANSSGRLPDAYSGGHDSSSRSHRYGG--GGRYEEYRGRS 786
           G        R L  +     P        S  R  R GG  GGR E   GRS
Sbjct: 339 GRHRVGRPDRGLSLSMERGCPPQRDSYSRSGCRVPRGGGRLGGRLERGGGRS 390



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 63/199 (31%), Positives = 77/199 (38%), Gaps = 23/199 (11%)

Query: 446 GRSDDAYSG--GHDSSSWSDCCGGGGRYEEYQGRSLDANS--GGCSPEAYSGGHDNSSWS 501
           G  D+ YS   G+ S  + +  G      EY  R    +S    C    YS         
Sbjct: 208 GPRDEGYSSRDGYSSRDYREPRGFAPSPGEYTHRDYGHSSVRDDCPLRGYS--------- 258

Query: 502 DRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYE-YRGRSH 560
           DR G GG   +   H   +    R P    G    ++   G    YGG GRYE YRG S 
Sbjct: 259 DRDGYGGRDRDYGDHL--SRGSHREPFESYGELRGAAPGRGTPPSYGGGGRYEEYRGYSP 316

Query: 561 DAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSW 620
           DA+SGG   D+YS  +  S + +R G        RG SL    G   P        S   
Sbjct: 317 DAYSGG--RDSYSSSYGRSDRYSR-GRHRVGRPDRGLSLSMERG--CPPQRDSYSRSGCR 371

Query: 621 SHRYGG--GGRYEEYRGRS 637
             R GG  GGR E   GRS
Sbjct: 372 VPRGGGRLGGRLERGGGRS 390


>gi|56699409 RNA binding motif protein, X-linked [Homo sapiens]
          Length = 391

 Score =  305 bits (780), Expect = 2e-82
 Identities = 202/447 (45%), Positives = 239/447 (53%), Gaps = 66/447 (14%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EADRP KLFIGGLN +T+EKAL+A FGKYG I++V LMKDR+TNKSRGFAFVTFESPA
Sbjct: 1   MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPA 60

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSS-RWVPPTPGSGSRSRFSHRTRGGGSSPQ 119
           DAK AARDMNGK LDGKAI V Q  KP+F+S  R  PP P S    R     RGG    +
Sbjct: 61  DAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTR 120

Query: 120 RPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMR 179
            PPS+G   D  GY+  F++   R P+P KRGPPPR    PP KR+ PS    S   GM 
Sbjct: 121 GPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRS-GGPPPKRSAPSGPVRS-SSGMG 178

Query: 180 GKAPTVSGQDGYSGLQPRRWAGPPHKRAVP--RSSLARIGGSGMPGKAPAVWGQDGYSGP 237
           G+AP   G+D Y         GPP +  +P  R         G   K       D YS  
Sbjct: 179 GRAPVSRGRDSY--------GGPPRREPLPSRRDVYLSPRDDGYSTK-------DSYSS- 222

Query: 238 RVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSK 297
                 P  RD  D+ P  RDY+ R YGHSS  D  P RG  +++GY GRD +Y+DHPS 
Sbjct: 223 ---RDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGY-GRDRDYSDHPSG 278

Query: 298 GSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAY 357
           GSYR+  +SYG    A P  G PPSYGG  RY++Y                         
Sbjct: 279 GSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSS----------------------- 315

Query: 358 SRDHSPKAYSGGRSSSSNGYSRSDRY--GEEGCYEEYRGRSPDAHSG---GRNSSSNSYG 412
           SRD     Y G R S S+  SRSD Y  G +    + RG  P    G    R+S S+S  
Sbjct: 316 SRD----GYGGSRDSYSS--SRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSR 369

Query: 413 QSHHYGGEGRYEEYRGRSHEARSGGRS 439
            +   GG       RG S   R GGRS
Sbjct: 370 GAPRGGG-------RGGSRSDRGGGRS 389



 Score =  126 bits (316), Expect = 1e-28
 Identities = 118/335 (35%), Positives = 144/335 (42%), Gaps = 45/335 (13%)

Query: 747  SLDANSSGRLPDAYSGGHDSSSRSHRYGGGG-RYEEYRGRSLDANSGGRSPN---AYSGG 802
            S ++   G  P   S G     R  R G GG R    RG  +D   GG S N   + S G
Sbjct: 88   SFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMD--DGGYSMNFNMSSSRG 145

Query: 803  HNSSSRNDPCRGGGRYEENRGHSLDANS----GGHSPNAYSGGRDSSSNSYDRSHRYGGG 858
                 R  P R GG   +    S    S    GG +P   S GRDS          YGG 
Sbjct: 146  PLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAP--VSRGRDS----------YGGP 193

Query: 859  GHYEEYRGRSHDTHSRGRSPDAHSGDHYTEA-YSRGRDSFSNSYGRSDH----YGRGGCY 913
               E    R  D +   R     + D Y+   Y   RD+   +    D+    YG     
Sbjct: 194  PRREPLPSR-RDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSR 252

Query: 914  EEYQGRSPNAYGG-GRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYG 972
            ++Y  R  +   G GR  + S++  G S+R      YE Y         G   S+  + G
Sbjct: 253  DDYPSRGYSDRDGYGRDRDYSDHPSGGSYR----DSYESY---------GNSRSAPPTRG 299

Query: 973  LSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETG 1032
                YGG   Y++Y  S  D Y G  D  S+S  RSD YS GRDRVGR +RGLP  ME G
Sbjct: 300  PPPSYGGSSRYDDYSSSR-DGYGGSRDSYSSS--RSDLYSSGRDRVGRQERGLPPSMERG 356

Query: 1033 SPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
             PP  DSYS S    PRGGGR G R +RG GRSRY
Sbjct: 357  YPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY 391



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 104/408 (25%), Positives = 138/408 (33%), Gaps = 45/408 (11%)

Query: 402 GGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSW 461
           GG N+ +N       +G  GR  E         +  R     +     DA     D +  
Sbjct: 13  GGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGK 72

Query: 462 SDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGG-HYEENRGHSLDA 520
           S   G   + E+    S ++   G  P   S G        R G GG     +RG  +D 
Sbjct: 73  S-LDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMD- 130

Query: 521 NSGGRSPDTH-SGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSS 579
             GG S + + S          G   R GG            A SG   + +  GG    
Sbjct: 131 -DGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPP------KRSAPSGPVRSSSGMGGRAPV 183

Query: 580 SQS-NRYGGGGCYEEYRGRS----LDANSGGRSPNAYSG-GHDSSSWSHRYGGGGRYEEY 633
           S+  + YGG    E    R        + G  + ++YS   + SS  +  Y    R   Y
Sbjct: 184 SRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTY 243

Query: 634 RGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAY-SGG 692
           R    D        D  S G+          G GR  +Y     D  SGG   D+Y S G
Sbjct: 244 R----DYGHSSSRDDYPSRGYSDRD------GYGRDRDYS----DHPSGGSYRDSYESYG 289

Query: 693 HDSSSQSNR-----YGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRS 747
           +  S+   R     YGG  RY++Y   S D   G R   + SR    SS  D  G   R 
Sbjct: 290 NSRSAPPTRGPPPSYGGSSRYDDYSS-SRDGYGGSRDSYSSSRSDLYSSGRDRVGRQERG 348

Query: 748 LDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRS 795
           L  +     P        SS  + R GG G     RG       GGRS
Sbjct: 349 LPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRG-------GGRS 389



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 82/290 (28%), Positives = 105/290 (36%), Gaps = 78/290 (26%)

Query: 483 SGGCSPEAYSGGH-DNSSWSDRYGVG---GHYEENRGHSLDANSGGRSP--DTHSGGHSS 536
           SGG       GGH D+  +S  + +    G     RG      SGG  P     SG   S
Sbjct: 116 SGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPP--PRSGGPPPKRSAPSGPVRS 173

Query: 537 SSNSYGQS------HRYGGEGRYEYRGRSHDAH-----SGGCSADAYSGGHDSSSQSNR- 584
           SS   G++        YGG  R E      D +      G  + D+YS     SS+  R 
Sbjct: 174 SSGMGGRAPVSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRD 233

Query: 585 ------------YGGGGCYEEYRGRSL-------------DANSGGRSPNAY-SGGHDSS 618
                       YG     ++Y  R               D  SGG   ++Y S G+  S
Sbjct: 234 YAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRS 293

Query: 619 SWSHR-----YGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDS--SGQSNCYGGG----G 667
           +   R     YGG  RY++Y            S D Y G  DS  S +S+ Y  G    G
Sbjct: 294 APPTRGPPPSYGGSSRYDDYSS----------SRDGYGGSRDSYSSSRSDLYSSGRDRVG 343

Query: 668 RYEEYRGRLLDANSGGRSP-DAYS--------GGHDSSSQSNRYGGGGRY 708
           R E  RG       G   P D+YS        GG    S+S+R GG  RY
Sbjct: 344 RQE--RGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY 391



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 88/313 (28%), Positives = 111/313 (35%), Gaps = 58/313 (18%)

Query: 363 PKAYSGGRSSSSNGYSRSDRYG--EEGCYE------EYRG-----RSPDAHSGG----RN 405
           P+   GGR  S        R G  ++G Y         RG     R P   SGG    R+
Sbjct: 106 PRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRSGGPPPKRS 165

Query: 406 SSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCC 465
           + S     S   GG  R    RGR      GG         R D   S   D  S  D  
Sbjct: 166 APSGPVRSSSGMGG--RAPVSRGRDSY---GGPPRREPLPSRRDVYLSPRDDGYSTKDSY 220

Query: 466 GGGGRYEEYQGRSLDANSGGCSPEAYSG---GHDNS-------SWSDRYGVGGHYEENRG 515
                  +Y   S D       P  Y+    GH +S        +SDR G G     +R 
Sbjct: 221 SS----RDYPS-SRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYG----RDRD 271

Query: 516 HSLDANSGGRSPDTHS--GGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYS 573
           +S D  SGG   D++   G   S+  + G    YGG  RY+    S D + G  S D+Y 
Sbjct: 272 YS-DHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGG--SRDSY- 327

Query: 574 GGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEY 633
               SSS+S+ Y  G      + R L  +     P        SS  + R GG       
Sbjct: 328 ----SSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGG------- 376

Query: 634 RGRSLDANSGGRS 646
           RG S     GGRS
Sbjct: 377 RGGSRSDRGGGRS 389


>gi|242117971 RNA binding motif protein, X-linked-like 1 [Homo
           sapiens]
          Length = 390

 Score =  296 bits (758), Expect = 7e-80
 Identities = 188/412 (45%), Positives = 224/412 (54%), Gaps = 45/412 (10%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EADRP KLFIGGLN +T+EKAL+  FGKYG I++V L+KDR+TNKSRGFAFVTFESPA
Sbjct: 1   MVEADRPGKLFIGGLNTETNEKALETVFGKYGRIVEVLLIKDRETNKSRGFAFVTFESPA 60

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSR-WVPPTPGSGSRSRFSHRTRGGGSSPQ 119
           DAK AARDMNGK LDGKAI V Q  KP+F+  R   PP P S    R     RGG    +
Sbjct: 61  DAKDAARDMNGKSLDGKAIKVEQATKPSFERGRHGPPPPPRSRGPPRGFGAGRGGSGGTR 120

Query: 120 RPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMR 179
            PPS+G   D  GY+  F++   R P+P KRGPPPR    P  KR+ PS L  S   GM 
Sbjct: 121 GPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRS-GGPSPKRSAPSGLVRS-SSGMG 178

Query: 180 GKAPTVSGQDGYSGLQPRRWAGPPHKRAVP--RSSLARIGGSGMPGKAPAVWGQDGYSGP 237
           G+AP   G+D Y         GPP +  +P  R         G   K       D YS  
Sbjct: 179 GRAPLSRGRDSY--------GGPPRREPLPSRRDVYLSPRDDGYSTK-------DSYSS- 222

Query: 238 RVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSK 297
                 P  RD  D+ P  RDY+ R YGHSS  D  P RG G+++GY GRD +Y+DHPS 
Sbjct: 223 ---RDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGY-GRDRDYSDHPSG 278

Query: 298 GSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQ------GNSPDACSE--------- 342
           GSYR+  +SYG    A    G PPSYGG  RY++Y       G S D+ S          
Sbjct: 279 GSYRDSYESYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSC 338

Query: 343 ---GRSSEALPVVLPDAY--SRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCY 389
              GR    LP  +   Y  SRD    +  G    +  G SRSDR G    Y
Sbjct: 339 DRVGRQERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390



 Score =  103 bits (257), Expect = 9e-22
 Identities = 110/335 (32%), Positives = 137/335 (40%), Gaps = 46/335 (13%)

Query: 747  SLDANSSGRLPDAYSGGHDSSSRSHRYGGGG-RYEEYRGRSLDANSGGRSPN---AYSGG 802
            S +    G  P   S G      + R G GG R    RG  +D   GG S N   + S G
Sbjct: 88   SFERGRHGPPPPPRSRGPPRGFGAGRGGSGGTRGPPSRGGHMD--DGGYSMNFNMSSSRG 145

Query: 803  HNSSSRNDPCRGGGRYEENRGHS----LDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGG 858
                 R  P R GG   +    S      +  GG +P   S GRDS          YGG 
Sbjct: 146  PLPVKRGPPPRSGGPSPKRSAPSGLVRSSSGMGGRAP--LSRGRDS----------YGGP 193

Query: 859  GHYEEYRGRSHDTHSRGRSPDAHSGDHYTEA-YSRGRDSFSNSYGRSDH----YGRGGCY 913
               E    R  D +   R     + D Y+   Y   RD+   +    D+    YG     
Sbjct: 194  PRREPLPSR-RDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSR 252

Query: 914  EEYQGRSPNAYGG-GRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYG 972
            ++Y  R      G GR  + S++  G S+R      YE Y         G   S+  + G
Sbjct: 253  DDYPSRGYGDRDGYGRDRDYSDHPSGGSYR----DSYESY---------GNSRSAPLTRG 299

Query: 973  LSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETG 1032
                YGG   Y++Y  S  D Y G  D  S+S  RSD YS   DRVGR +RGLP  +E G
Sbjct: 300  PPPSYGGSSRYDDYSSSR-DGYGGSRDSYSSS--RSDLYS-SCDRVGRQERGLPPSVERG 355

Query: 1033 SPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
             P   DSYS S    PRG G  G R +RG GRSRY
Sbjct: 356  YPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 71/246 (28%), Positives = 92/246 (37%), Gaps = 61/246 (24%)

Query: 643 GGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGR----LLDANSGGRSPDAYSGGHDSSSQ 698
           GGR+P   S G DS      YGG  R E    R    L   + G  + D+YS     SS+
Sbjct: 178 GGRAP--LSRGRDS------YGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSR 229

Query: 699 SNR-------------YGGGGRYEEY--RGHSLDANSGGRSPDTYSRGHDSSSQSDHYGG 743
             R             YG     ++Y  RG+  D +  GR  D YS      S  D Y  
Sbjct: 230 DTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYG-DRDGYGRDRD-YSDHPSGGSYRDSYES 287

Query: 744 GGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGH 803
            G S  A  +   P +             YGG  RY++Y   S   +  G S ++Y    
Sbjct: 288 YGNSRSAPLTRGPPPS-------------YGGSSRYDDY---SSSRDGYGGSRDSY---- 327

Query: 804 NSSSRND---PCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGH 860
            SSSR+D    C   GR E     S++          Y   RDS S+S   + R  G G 
Sbjct: 328 -SSSRSDLYSSCDRVGRQERGLPPSVE--------RGYPSSRDSYSSSSRGAPRGAGPGG 378

Query: 861 YEEYRG 866
               RG
Sbjct: 379 SRSDRG 384



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 79/287 (27%), Positives = 103/287 (35%), Gaps = 73/287 (25%)

Query: 483 SGGCSPEAYSGGH-DNSSWSDRYGVG---GHYEENRGHSLDANSGGRSP--DTHSGGHSS 536
           SGG       GGH D+  +S  + +    G     RG      SGG SP     SG   S
Sbjct: 116 SGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPP--PRSGGPSPKRSAPSGLVRS 173

Query: 537 SSNSYGQS------HRYGGEGRYEYRGRSHDAH-----SGGCSADAYSGGHDSSSQSNR- 584
           SS   G++        YGG  R E      D +      G  + D+YS     SS+  R 
Sbjct: 174 SSGMGGRAPLSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRD 233

Query: 585 ------------YGGGGCYEEYRGRSL-------------DANSGGRSPNAY-SGGHDSS 618
                       YG     ++Y  R               D  SGG   ++Y S G+  S
Sbjct: 234 YAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRS 293

Query: 619 SWSHR-----YGGGGRYEEYRGRSLDANSGGRSPDAYSGGHD--SSGQSNCYGGGGRY-E 670
           +   R     YGG  RY++Y            S D Y G  D  SS +S+ Y    R   
Sbjct: 294 APLTRGPPPSYGGSSRYDDY----------SSSRDGYGGSRDSYSSSRSDLYSSCDRVGR 343

Query: 671 EYRGRLLDANSG-GRSPDAYS--------GGHDSSSQSNRYGGGGRY 708
           + RG       G   S D+YS        G     S+S+R GG  RY
Sbjct: 344 QERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 96/346 (27%), Positives = 120/346 (34%), Gaps = 74/346 (21%)

Query: 301 REPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRD 360
           R P + +G   G +     PPS GG      Y  N   + S G     LPV         
Sbjct: 103 RGPPRGFGAGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRG----PLPV--------K 150

Query: 361 HSPKAYSGGRS---SSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHY 417
             P   SGG S   S+ +G  RS             GR+P   S GR+S          Y
Sbjct: 151 RGPPPRSGGPSPKRSAPSGLVRSS--------SGMGGRAP--LSRGRDS----------Y 190

Query: 418 GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGR 477
           GG  R E    R           D +   R DD YS     SS            +Y   
Sbjct: 191 GGPPRREPLPSRR----------DVYLSPR-DDGYSTKDSYSS-----------RDYPS- 227

Query: 478 SLDANSGGCSPEAYSG---GHDNSSW---SDRYGVGGHYEENRGHSLDANSGGRSPDTHS 531
           S D       P  Y+    GH +S     S  YG    Y  +R +S D  SGG   D++ 
Sbjct: 228 SRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYS-DHPSGGSYRDSYE 286

Query: 532 --GGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGG----HDSSSQSNRY 585
             G   S+  + G    YGG  RY+    S D + G  S D+YS      + S  +  R 
Sbjct: 287 SYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGG--SRDSYSSSRSDLYSSCDRVGRQ 344

Query: 586 GGGGCYEEYRGRSLDANS-GGRSPNAYSGGHDSSSWSHRYGGGGRY 630
             G      RG     +S    S  A  G     S S R GG  RY
Sbjct: 345 ERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390


>gi|21361809 RNA binding motif protein, X-linked-like 1 [Homo
           sapiens]
          Length = 390

 Score =  296 bits (758), Expect = 7e-80
 Identities = 188/412 (45%), Positives = 224/412 (54%), Gaps = 45/412 (10%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EADRP KLFIGGLN +T+EKAL+  FGKYG I++V L+KDR+TNKSRGFAFVTFESPA
Sbjct: 1   MVEADRPGKLFIGGLNTETNEKALETVFGKYGRIVEVLLIKDRETNKSRGFAFVTFESPA 60

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSR-WVPPTPGSGSRSRFSHRTRGGGSSPQ 119
           DAK AARDMNGK LDGKAI V Q  KP+F+  R   PP P S    R     RGG    +
Sbjct: 61  DAKDAARDMNGKSLDGKAIKVEQATKPSFERGRHGPPPPPRSRGPPRGFGAGRGGSGGTR 120

Query: 120 RPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMR 179
            PPS+G   D  GY+  F++   R P+P KRGPPPR    P  KR+ PS L  S   GM 
Sbjct: 121 GPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPPPRS-GGPSPKRSAPSGLVRS-SSGMG 178

Query: 180 GKAPTVSGQDGYSGLQPRRWAGPPHKRAVP--RSSLARIGGSGMPGKAPAVWGQDGYSGP 237
           G+AP   G+D Y         GPP +  +P  R         G   K       D YS  
Sbjct: 179 GRAPLSRGRDSY--------GGPPRREPLPSRRDVYLSPRDDGYSTK-------DSYSS- 222

Query: 238 RVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSK 297
                 P  RD  D+ P  RDY+ R YGHSS  D  P RG G+++GY GRD +Y+DHPS 
Sbjct: 223 ---RDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGY-GRDRDYSDHPSG 278

Query: 298 GSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQ------GNSPDACSE--------- 342
           GSYR+  +SYG    A    G PPSYGG  RY++Y       G S D+ S          
Sbjct: 279 GSYRDSYESYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSC 338

Query: 343 ---GRSSEALPVVLPDAY--SRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCY 389
              GR    LP  +   Y  SRD    +  G    +  G SRSDR G    Y
Sbjct: 339 DRVGRQERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390



 Score =  103 bits (257), Expect = 9e-22
 Identities = 110/335 (32%), Positives = 137/335 (40%), Gaps = 46/335 (13%)

Query: 747  SLDANSSGRLPDAYSGGHDSSSRSHRYGGGG-RYEEYRGRSLDANSGGRSPN---AYSGG 802
            S +    G  P   S G      + R G GG R    RG  +D   GG S N   + S G
Sbjct: 88   SFERGRHGPPPPPRSRGPPRGFGAGRGGSGGTRGPPSRGGHMD--DGGYSMNFNMSSSRG 145

Query: 803  HNSSSRNDPCRGGGRYEENRGHS----LDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGG 858
                 R  P R GG   +    S      +  GG +P   S GRDS          YGG 
Sbjct: 146  PLPVKRGPPPRSGGPSPKRSAPSGLVRSSSGMGGRAP--LSRGRDS----------YGGP 193

Query: 859  GHYEEYRGRSHDTHSRGRSPDAHSGDHYTEA-YSRGRDSFSNSYGRSDH----YGRGGCY 913
               E    R  D +   R     + D Y+   Y   RD+   +    D+    YG     
Sbjct: 194  PRREPLPSR-RDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSR 252

Query: 914  EEYQGRSPNAYGG-GRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYG 972
            ++Y  R      G GR  + S++  G S+R      YE Y         G   S+  + G
Sbjct: 253  DDYPSRGYGDRDGYGRDRDYSDHPSGGSYR----DSYESY---------GNSRSAPLTRG 299

Query: 973  LSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETG 1032
                YGG   Y++Y  S  D Y G  D  S+S  RSD YS   DRVGR +RGLP  +E G
Sbjct: 300  PPPSYGGSSRYDDYSSSR-DGYGGSRDSYSSS--RSDLYS-SCDRVGRQERGLPPSVERG 355

Query: 1033 SPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
             P   DSYS S    PRG G  G R +RG GRSRY
Sbjct: 356  YPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 71/246 (28%), Positives = 92/246 (37%), Gaps = 61/246 (24%)

Query: 643 GGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGR----LLDANSGGRSPDAYSGGHDSSSQ 698
           GGR+P   S G DS      YGG  R E    R    L   + G  + D+YS     SS+
Sbjct: 178 GGRAP--LSRGRDS------YGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSR 229

Query: 699 SNR-------------YGGGGRYEEY--RGHSLDANSGGRSPDTYSRGHDSSSQSDHYGG 743
             R             YG     ++Y  RG+  D +  GR  D YS      S  D Y  
Sbjct: 230 DTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYG-DRDGYGRDRD-YSDHPSGGSYRDSYES 287

Query: 744 GGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGH 803
            G S  A  +   P +             YGG  RY++Y   S   +  G S ++Y    
Sbjct: 288 YGNSRSAPLTRGPPPS-------------YGGSSRYDDY---SSSRDGYGGSRDSY---- 327

Query: 804 NSSSRND---PCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGH 860
            SSSR+D    C   GR E     S++          Y   RDS S+S   + R  G G 
Sbjct: 328 -SSSRSDLYSSCDRVGRQERGLPPSVE--------RGYPSSRDSYSSSSRGAPRGAGPGG 378

Query: 861 YEEYRG 866
               RG
Sbjct: 379 SRSDRG 384



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 79/287 (27%), Positives = 103/287 (35%), Gaps = 73/287 (25%)

Query: 483 SGGCSPEAYSGGH-DNSSWSDRYGVG---GHYEENRGHSLDANSGGRSP--DTHSGGHSS 536
           SGG       GGH D+  +S  + +    G     RG      SGG SP     SG   S
Sbjct: 116 SGGTRGPPSRGGHMDDGGYSMNFNMSSSRGPLPVKRGPP--PRSGGPSPKRSAPSGLVRS 173

Query: 537 SSNSYGQS------HRYGGEGRYEYRGRSHDAH-----SGGCSADAYSGGHDSSSQSNR- 584
           SS   G++        YGG  R E      D +      G  + D+YS     SS+  R 
Sbjct: 174 SSGMGGRAPLSRGRDSYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRD 233

Query: 585 ------------YGGGGCYEEYRGRSL-------------DANSGGRSPNAY-SGGHDSS 618
                       YG     ++Y  R               D  SGG   ++Y S G+  S
Sbjct: 234 YAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRS 293

Query: 619 SWSHR-----YGGGGRYEEYRGRSLDANSGGRSPDAYSGGHD--SSGQSNCYGGGGRY-E 670
           +   R     YGG  RY++Y            S D Y G  D  SS +S+ Y    R   
Sbjct: 294 APLTRGPPPSYGGSSRYDDY----------SSSRDGYGGSRDSYSSSRSDLYSSCDRVGR 343

Query: 671 EYRGRLLDANSG-GRSPDAYS--------GGHDSSSQSNRYGGGGRY 708
           + RG       G   S D+YS        G     S+S+R GG  RY
Sbjct: 344 QERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 96/346 (27%), Positives = 120/346 (34%), Gaps = 74/346 (21%)

Query: 301 REPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRD 360
           R P + +G   G +     PPS GG      Y  N   + S G     LPV         
Sbjct: 103 RGPPRGFGAGRGGSGGTRGPPSRGGHMDDGGYSMNFNMSSSRG----PLPV--------K 150

Query: 361 HSPKAYSGGRS---SSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHY 417
             P   SGG S   S+ +G  RS             GR+P   S GR+S          Y
Sbjct: 151 RGPPPRSGGPSPKRSAPSGLVRSS--------SGMGGRAP--LSRGRDS----------Y 190

Query: 418 GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGR 477
           GG  R E    R           D +   R DD YS     SS            +Y   
Sbjct: 191 GGPPRREPLPSRR----------DVYLSPR-DDGYSTKDSYSS-----------RDYPS- 227

Query: 478 SLDANSGGCSPEAYSG---GHDNSSW---SDRYGVGGHYEENRGHSLDANSGGRSPDTHS 531
           S D       P  Y+    GH +S     S  YG    Y  +R +S D  SGG   D++ 
Sbjct: 228 SRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYGDRDGYGRDRDYS-DHPSGGSYRDSYE 286

Query: 532 --GGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGG----HDSSSQSNRY 585
             G   S+  + G    YGG  RY+    S D + G  S D+YS      + S  +  R 
Sbjct: 287 SYGNSRSAPLTRGPPPSYGGSSRYDDYSSSRDGYGG--SRDSYSSSRSDLYSSCDRVGRQ 344

Query: 586 GGGGCYEEYRGRSLDANS-GGRSPNAYSGGHDSSSWSHRYGGGGRY 630
             G      RG     +S    S  A  G     S S R GG  RY
Sbjct: 345 ERGLPPSVERGYPSSRDSYSSSSRGAPRGAGPGGSRSDRGGGRSRY 390


>gi|56090533 RNA binding motif protein, Y-linked, family 1, member D
           [Homo sapiens]
          Length = 496

 Score =  182 bits (462), Expect = 1e-45
 Identities = 178/531 (33%), Positives = 224/531 (42%), Gaps = 68/531 (12%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EAD P KLFIGGLN +T+EK LKA FGK+G I +V L+KDR T+KSRGFAF+TFE+PA
Sbjct: 1   MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPA 59

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKS-SRWVPPTPG---SGSRSRFSHRTRGGGS 116
           DAK AA+DMNGK L GKAI V Q  KP+F+S  R  PP      S S S  S R   GG+
Sbjct: 60  DAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGT 119

Query: 117 SPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGC 176
               P  +G  DDG GY     +   R  +P KRGP  R    PP K++ PS++A S   
Sbjct: 120 RGWLPSQEGHLDDG-GYTPDLKMSYSRGLIPVKRGPSSRS-GGPPPKKSAPSAVARS-NS 176

Query: 177 GMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSG 236
            M  + P    ++ Y G+ PR            R++++      M  +       DG   
Sbjct: 177 WMGSQGPMSQRRENY-GVPPR------------RATISSWRNDRMSTRHDGYATNDGNH- 222

Query: 237 PRVREPLPPCRDPGDFVPALRDY--------------SRRYYGHSSVPDYRPLRGDGNQN 282
                  P C++  D+ P  R Y              SR Y  H S  + R        +
Sbjct: 223 -------PSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGH 275

Query: 283 GYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTP-PSYGGGCRYEEYQGNSPDACS 341
            YR   H   D      YR    S      A P  G     YG   R+E Y     +  S
Sbjct: 276 AYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPS 335

Query: 342 EGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHS 401
              + +  P     AY RD+    +S     SS GYS  D YGE        GR    H 
Sbjct: 336 SRETRDYAPPHRDYAY-RDY---GHSSWDEHSSRGYSYHDGYGEA------LGRDHSEHL 385

Query: 402 GGRN--SSSNSYGQSHHY-GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYS--GGH 456
            G +   +   YG SH      G    Y G +  A S  R       GRS ++YS  G  
Sbjct: 386 SGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRD----RYGRSWESYSSCGDF 441

Query: 457 DSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAY-----SGGHDNSSWSD 502
                   C    R     GR L      C   +Y      GG   S   D
Sbjct: 442 HYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGD 492



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 105/403 (26%), Positives = 147/403 (36%), Gaps = 62/403 (15%)

Query: 648  DAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYS-----GGHDSSSQSNRY 702
            DA +   D +G+S  +G   + E+ +     +  G R P A S      G   S++ +R 
Sbjct: 60   DAKNAAKDMNGKS-LHGKAIKVEQAKKPSFQSG-GRRRPPASSRNRSPSGSLRSARGSRG 117

Query: 703  GGGGRYEEYRGHSLDANSGGRSPD---TYSRG--HDSSSQSDHYGGGGRSLDANSSGRLP 757
            G  G      GH  D   GG +PD   +YSRG        S   GG      A S+    
Sbjct: 118  GTRGWLPSQEGHLDD---GGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARS 174

Query: 758  DAYSGGHDS-SSRSHRYGGGGR---YEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR 813
            +++ G     S R   YG   R      +R   +     G + N   G H S        
Sbjct: 175  NSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN--DGNHPSC------- 225

Query: 814  GGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHS 873
                 +E R ++  +    +  N +S   + SS  Y R+HR            R +   S
Sbjct: 226  -----QETRDYAPPSRGYAYRDNGHSNRDEHSSRGY-RNHR-------SSRETRDYAPPS 272

Query: 874  RGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHY--GRGGCYEEYQGRSPNAYGGGRGLN 931
            RG +   +      E+YSRG  +  +S    ++    RG  Y +Y G S       RG  
Sbjct: 273  RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDY-GHSRRHESYSRGYR 331

Query: 932  SSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYG---GGGHYEEYQG 988
            +  +S   +  Y    R   YR      HS   + S + Y   D YG   G  H E   G
Sbjct: 332  NHPSSR-ETRDYAPPHRDYAYR---DYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSG 387

Query: 989  -SLPDA---YSGDHDR-----SSNSYGRS--DRYSRGRDRVGR 1020
             S  DA   Y   H          SYG S    YS  RDR GR
Sbjct: 388  SSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGR 430


>gi|4826974 RNA binding motif protein, Y-linked, family 1, member A1
           [Homo sapiens]
          Length = 496

 Score =  182 bits (461), Expect = 2e-45
 Identities = 178/531 (33%), Positives = 224/531 (42%), Gaps = 68/531 (12%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EAD P KLFIGGLN +T+EK LKA FGK+G I +V L+KDR T+KSRGFAF+TFE+PA
Sbjct: 1   MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPA 59

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKS-SRWVPPTPG---SGSRSRFSHRTRGGGS 116
           DAK AA+DMNGK L GKAI V Q  KP+F+S  R  PP      S S S  S R   GG+
Sbjct: 60  DAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGT 119

Query: 117 SPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGC 176
               P  +G  DDG GY     +   R  +P KRGP  R    PP K++ PS++A S   
Sbjct: 120 RGWLPSHEGHLDDG-GYTPDLKMSYSRGLIPVKRGPSSRS-GGPPPKKSAPSAVARS-NS 176

Query: 177 GMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSG 236
            M  + P    ++ Y G+ PR            R++++      M  +       DG   
Sbjct: 177 WMGSQGPMSQRRENY-GVPPR------------RATISSWRNDRMSTRHDGYATNDGNH- 222

Query: 237 PRVREPLPPCRDPGDFVPALRDY--------------SRRYYGHSSVPDYRPLRGDGNQN 282
                  P C++  D+ P  R Y              SR Y  H S  + R        +
Sbjct: 223 -------PSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGH 275

Query: 283 GYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTP-PSYGGGCRYEEYQGNSPDACS 341
            YR   H   D      YR    S      A P  G     YG   R+E Y     +  S
Sbjct: 276 AYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPS 335

Query: 342 EGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHS 401
              + +  P     AY RD+    +S     SS GYS  D YGE        GR    H 
Sbjct: 336 SRETRDYAPPHRDYAY-RDY---GHSSWDEHSSRGYSYHDGYGEA------LGRDHSEHL 385

Query: 402 GGRN--SSSNSYGQSHHY-GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYS--GGH 456
            G +   +   YG SH      G    Y G +  A S  R       GRS ++YS  G  
Sbjct: 386 SGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRD----RYGRSWESYSSCGDF 441

Query: 457 DSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAY-----SGGHDNSSWSD 502
                   C    R     GR L      C   +Y      GG   S   D
Sbjct: 442 HYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGD 492



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 105/403 (26%), Positives = 148/403 (36%), Gaps = 62/403 (15%)

Query: 648  DAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYS-----GGHDSSSQSNRY 702
            DA +   D +G+S  +G   + E+ +     +  G R P A S      G   S++ +R 
Sbjct: 60   DAKNAAKDMNGKS-LHGKAIKVEQAKKPSFQSG-GRRRPPASSRNRSPSGSLRSARGSRG 117

Query: 703  GGGGRYEEYRGHSLDANSGGRSPD---TYSRG--HDSSSQSDHYGGGGRSLDANSSGRLP 757
            G  G    + GH  D   GG +PD   +YSRG        S   GG      A S+    
Sbjct: 118  GTRGWLPSHEGHLDD---GGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARS 174

Query: 758  DAYSGGHDS-SSRSHRYGGGGR---YEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR 813
            +++ G     S R   YG   R      +R   +     G + N   G H S        
Sbjct: 175  NSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN--DGNHPSC------- 225

Query: 814  GGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHS 873
                 +E R ++  +    +  N +S   + SS  Y R+HR            R +   S
Sbjct: 226  -----QETRDYAPPSRGYAYRDNGHSNRDEHSSRGY-RNHR-------SSRETRDYAPPS 272

Query: 874  RGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHY--GRGGCYEEYQGRSPNAYGGGRGLN 931
            RG +   +      E+YSRG  +  +S    ++    RG  Y +Y G S       RG  
Sbjct: 273  RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDY-GHSRRHESYSRGYR 331

Query: 932  SSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYG---GGGHYEEYQG 988
            +  +S   +  Y    R   YR      HS   + S + Y   D YG   G  H E   G
Sbjct: 332  NHPSSR-ETRDYAPPHRDYAYR---DYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSG 387

Query: 989  -SLPDA---YSGDHDR-----SSNSYGRS--DRYSRGRDRVGR 1020
             S  DA   Y   H          SYG S    YS  RDR GR
Sbjct: 388  SSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDRYGR 430


>gi|56090527 RNA binding motif protein, Y-linked, family 1, member E
           [Homo sapiens]
          Length = 496

 Score =  181 bits (459), Expect = 3e-45
 Identities = 177/531 (33%), Positives = 224/531 (42%), Gaps = 68/531 (12%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EAD P KLFIGGLN +T+EK LKA FGK+G I +V L+KDR T+KSRGFAF+TFE+PA
Sbjct: 1   MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPA 59

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKS-SRWVPPTPG---SGSRSRFSHRTRGGGS 116
           DAK AA+DMNGK L GKAI V Q  KP+F+S  R  PP      S S S  S R   GG+
Sbjct: 60  DAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGT 119

Query: 117 SPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGC 176
               P  +G  DDG GY     +   R  +P KRGP  R    PP K++ PS++A S   
Sbjct: 120 RGWLPSQEGHLDDG-GYTPDLKMSYSRGLIPVKRGPSSRS-GGPPPKKSAPSAVARS-NS 176

Query: 177 GMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSG 236
            M  + P    ++ Y G+ PR            R++++      M  +       DG   
Sbjct: 177 WMGSQGPMSQRRENY-GVPPR------------RATISSWRNDRMSTRHDGYATNDGNH- 222

Query: 237 PRVREPLPPCRDPGDFVPALRDY--------------SRRYYGHSSVPDYRPLRGDGNQN 282
                  P C++  D+ P  R Y              SR Y  H S  + R        +
Sbjct: 223 -------PSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGH 275

Query: 283 GYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTP-PSYGGGCRYEEYQGNSPDACS 341
            YR   H   D      YR    S      A P  G     YG   R+E Y     +  S
Sbjct: 276 AYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPS 335

Query: 342 EGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHS 401
              + +  P     AY RD+    +S     SS GYS  D YGE        GR    H 
Sbjct: 336 SRETRDYAPPHRDYAY-RDY---GHSSWDEHSSRGYSYHDGYGEA------LGRDHSEHL 385

Query: 402 GGRN--SSSNSYGQSHHY-GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYS--GGH 456
            G +   +   YG +H      G    Y G +  A S  R       GRS ++YS  G  
Sbjct: 386 SGSSYRDALQRYGTAHGAPPARGPRMSYGGSTCHAYSNTRD----RYGRSWESYSSCGDF 441

Query: 457 DSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAY-----SGGHDNSSWSD 502
                   C    R     GR L      C   +Y      GG   S   D
Sbjct: 442 HYCDREHVCRKDQRNPPSLGRVLPDPREACGSSSYVASIVDGGESRSEKGD 492



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 105/403 (26%), Positives = 147/403 (36%), Gaps = 62/403 (15%)

Query: 648  DAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYS-----GGHDSSSQSNRY 702
            DA +   D +G+S  +G   + E+ +     +  G R P A S      G   S++ +R 
Sbjct: 60   DAKNAAKDMNGKS-LHGKAIKVEQAKKPSFQSG-GRRRPPASSRNRSPSGSLRSARGSRG 117

Query: 703  GGGGRYEEYRGHSLDANSGGRSPD---TYSRG--HDSSSQSDHYGGGGRSLDANSSGRLP 757
            G  G      GH  D   GG +PD   +YSRG        S   GG      A S+    
Sbjct: 118  GTRGWLPSQEGHLDD---GGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARS 174

Query: 758  DAYSGGHDS-SSRSHRYGGGGR---YEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR 813
            +++ G     S R   YG   R      +R   +     G + N   G H S        
Sbjct: 175  NSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN--DGNHPSC------- 225

Query: 814  GGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHS 873
                 +E R ++  +    +  N +S   + SS  Y R+HR            R +   S
Sbjct: 226  -----QETRDYAPPSRGYAYRDNGHSNRDEHSSRGY-RNHR-------SSRETRDYAPPS 272

Query: 874  RGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHY--GRGGCYEEYQGRSPNAYGGGRGLN 931
            RG +   +      E+YSRG  +  +S    ++    RG  Y +Y G S       RG  
Sbjct: 273  RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDY-GHSRRHESYSRGYR 331

Query: 932  SSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYG---GGGHYEEYQG 988
            +  +S   +  Y    R   YR      HS   + S + Y   D YG   G  H E   G
Sbjct: 332  NHPSSR-ETRDYAPPHRDYAYR---DYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSG 387

Query: 989  -SLPDA---YSGDHDR-----SSNSYGRS--DRYSRGRDRVGR 1020
             S  DA   Y   H          SYG S    YS  RDR GR
Sbjct: 388  SSYRDALQRYGTAHGAPPARGPRMSYGGSTCHAYSNTRDRYGR 430


>gi|54633344 RNA binding motif protein, Y-linked, family 1, member B
           [Homo sapiens]
          Length = 496

 Score =  181 bits (458), Expect = 4e-45
 Identities = 167/479 (34%), Positives = 212/479 (44%), Gaps = 61/479 (12%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EAD P KLFIGGLN +T+EK LKA FGK+G I +V L+KDR T+KSRGFAF+TFE+PA
Sbjct: 1   MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPA 59

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKS-SRWVPPTPG---SGSRSRFSHRTRGGGS 116
           DAK AA+DMNGK L GKAI V Q  KP+F+S  R  PP      S S S  S R   GG+
Sbjct: 60  DAKNAAKDMNGKSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSRGGT 119

Query: 117 SPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGC 176
               P  +G  DDG GY     +   R  +P KRGP  R    PP K++ PS++A S   
Sbjct: 120 RGWLPSQEGHLDDG-GYTPDLKMSYSRGLIPVKRGPSSRS-GGPPPKKSAPSAVARS-NS 176

Query: 177 GMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSG 236
            M  + P    ++ Y G+ PR            R++++      M  +       DG   
Sbjct: 177 WMGSQGPMSQRRENY-GVPPR------------RATISSWRNDRMSTRHDGYATNDGNH- 222

Query: 237 PRVREPLPPCRDPGDFVPALRDY--------------SRRYYGHSSVPDYRPLRGDGNQN 282
                  P C++  D+ P  R Y              SR Y  H S  + R        +
Sbjct: 223 -------PSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGH 275

Query: 283 GYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTP-PSYGGGCRYEEYQGNSPDACS 341
            YR   H   D      YR    S      A P  G     YG   R+E Y     +  S
Sbjct: 276 AYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPS 335

Query: 342 EGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHS 401
              + +  P     AY RD+    +S     SS GYS  D YGE        GR    H 
Sbjct: 336 SRETRDYAPPHRDYAY-RDY---GHSSWDEHSSRGYSYHDGYGEA------LGRDHSEHL 385

Query: 402 GGRN--SSSNSYGQSHHY-GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHD 457
            G +   +   YG SH      G    Y G +  A S  R       GRS ++YS   D
Sbjct: 386 SGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRD----RYGRSWESYSSCGD 440



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 121/474 (25%), Positives = 171/474 (36%), Gaps = 91/474 (19%)

Query: 648  DAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYS-----GGHDSSSQSNRY 702
            DA +   D +G+S  +G   + E+ +     +  G R P A S      G   S++ +R 
Sbjct: 60   DAKNAAKDMNGKS-LHGKAIKVEQAKKPSFQSG-GRRRPPASSRNRSPSGSLRSARGSRG 117

Query: 703  GGGGRYEEYRGHSLDANSGGRSPD---TYSRG--HDSSSQSDHYGGGGRSLDANSSGRLP 757
            G  G      GH  D   GG +PD   +YSRG        S   GG      A S+    
Sbjct: 118  GTRGWLPSQEGHLDD---GGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARS 174

Query: 758  DAYSGGHDS-SSRSHRYGGGGR---YEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR 813
            +++ G     S R   YG   R      +R   +     G + N   G H S        
Sbjct: 175  NSWMGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN--DGNHPSC------- 225

Query: 814  GGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHS 873
                 +E R ++  +    +  N +S   + SS  Y R+HR            R +   S
Sbjct: 226  -----QETRDYAPPSRGYAYRDNGHSNRDEHSSRGY-RNHR-------SSRETRDYAPPS 272

Query: 874  RGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHY--GRGGCYEEYQGRSPNAYGGGRGLN 931
            RG +   +      E+YSRG  +  +S    ++    RG  Y +Y G S       RG  
Sbjct: 273  RGHAYRDYGHSRRDESYSRGYRNRRSSRETREYAPPSRGHGYRDY-GHSRRHESYSRGYR 331

Query: 932  SSNNSHGRSHRYGGGGR---YEEYRGPSPDAHSG-------------GRDSSIKSYGLS- 974
            +  +S   +  Y    R   Y +Y   S D HS              GRD S    G S 
Sbjct: 332  NHPSSR-ETRDYAPPHRDYAYRDYGHSSWDEHSSRGYSYHDGYGEALGRDHSEHLSGSSY 390

Query: 975  ----DRYG-------GGGHYEEYQGSLPDAYSGDHDRSSNSYGRS--------DRYSRGR 1015
                 RYG         G    Y GS   AYS   DR    YGRS        D +   R
Sbjct: 391  RDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRDR----YGRSWESYSSCGDFHYCDR 446

Query: 1016 DRVGRPDRGLPLPMETGSPPLHDSYSRSG--CRVPRGGGRQGGRFERGEGRSRY 1067
            + V R D+  P  +    P   ++Y  S     +  GG     R E+G+  SRY
Sbjct: 447  EHVCRKDQRNPPSLGRVLPDPREAYGSSSYVASIVDGG---ESRSEKGDS-SRY 496


>gi|34303937 RNA binding motif protein, Y-linked, family 1, member F
           [Homo sapiens]
          Length = 496

 Score =  179 bits (453), Expect = 2e-44
 Identities = 166/479 (34%), Positives = 211/479 (44%), Gaps = 61/479 (12%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EAD P KLFIGGLN +T+EK LKA FGK+G I +V L+KDR T+KSRGFAF+TFE+PA
Sbjct: 1   MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPA 59

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKS-SRWVPPTPG---SGSRSRFSHRTRGGGS 116
           DAK AA+DMNG  L GKAI V Q  KP+F+S  R  PP      S S S  S R   GG+
Sbjct: 60  DAKNAAKDMNGTSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSSGGT 119

Query: 117 SPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGC 176
               P  +G  DDG GY     +   R  +P KRGP  R    PP K++ PS++A S   
Sbjct: 120 RGWLPSHEGHLDDG-GYTPDLKMSYSRGLIPVKRGPSSRS-GGPPPKKSAPSAVARS-NS 176

Query: 177 GMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSG 236
            M  + P    ++ Y G+ PR            R++++      M  +       DG   
Sbjct: 177 WMGSQGPMSQRRENY-GVPPR------------RATISSWRNDRMSTRHDGYATNDGNH- 222

Query: 237 PRVREPLPPCRDPGDFVPALRDY--------------SRRYYGHSSVPDYRPLRGDGNQN 282
                  P C++  D+ P  R Y              SR Y  H S  + R        +
Sbjct: 223 -------PSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGH 275

Query: 283 GYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTP-PSYGGGCRYEEYQGNSPDACS 341
            YR   H   D      YR    S      A P  G     YG   R+E Y     +  S
Sbjct: 276 AYRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPS 335

Query: 342 EGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHS 401
              + +  P     AY RD+    +S     SS GYS  D YGE        GR    H 
Sbjct: 336 SRETRDYAPPHRDYAY-RDY---GHSSWDEHSSRGYSYHDGYGEA------LGRDHSEHL 385

Query: 402 GGRN--SSSNSYGQSHHY-GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHD 457
            G +   +   YG SH      G    Y G +  A S  R       GRS ++YS   D
Sbjct: 386 SGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRD----RYGRSWESYSSCGD 440



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 121/467 (25%), Positives = 164/467 (35%), Gaps = 77/467 (16%)

Query: 648  DAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSS--QSNRYGGG 705
            DA +   D +G S  +G   + E+ +     +  G R P A S     S   +S R   G
Sbjct: 60   DAKNAAKDMNGTS-LHGKAIKVEQAKKPSFQSG-GRRRPPASSRNRSPSGSLRSARGSSG 117

Query: 706  GRYEEYRGHSLDANSGGRSPD---TYSRG--HDSSSQSDHYGGGGRSLDANSSGRLPDAY 760
            G       H    + GG +PD   +YSRG        S   GG      A S+    +++
Sbjct: 118  GTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSW 177

Query: 761  SGGHDS-SSRSHRYGGGGR---YEEYRGRSLDANSGGRSPNAYSGGHNSSSRND---PCR 813
             G     S R   YG   R      +R   +     G + N   G H S        P  
Sbjct: 178  MGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN--DGNHPSCQETRDYAPPS 235

Query: 814  GGGRYEENRGHSLDANSGGHSPNAYSGGRDS-SSNSY---DRSHRYGGGGH--------- 860
             G  Y +N GHS   N   HS   Y   R S  +  Y    R H Y   GH         
Sbjct: 236  RGYAYRDN-GHS---NRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSR 291

Query: 861  -YEEYRG----RSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHY--GRGGCY 913
             Y  +R     R +   SRG     +      E+YSRG  +  +S    D+    R   Y
Sbjct: 292  GYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAY 351

Query: 914  EEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRD--SSIKSY 971
             +Y            G +S +    R + Y  G  Y E  G     H  G     +++ Y
Sbjct: 352  RDY------------GHSSWDEHSSRGYSYHDG--YGEALGRDHSEHLSGSSYRDALQRY 397

Query: 972  GLS-DRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRS--------DRYSRGRDRVGRPD 1022
            G S       G    Y GS   AYS   DR    YGRS        D +   R+ V R D
Sbjct: 398  GTSHGAPPARGPRMSYGGSTCHAYSNTRDR----YGRSWESYSSCGDFHYCDREHVCRKD 453

Query: 1023 RGLPLPMETGSPPLHDSYSRSG--CRVPRGGGRQGGRFERGEGRSRY 1067
            +  P  +    P   ++Y  S     +  GG     R E+G+  SRY
Sbjct: 454  QRNPPSLGRVLPDPREAYGSSSYVASIVDGG---ESRSEKGDS-SRY 496


>gi|56090529 RNA binding motif protein, Y-linked, family 1, member J
           [Homo sapiens]
          Length = 496

 Score =  179 bits (453), Expect = 2e-44
 Identities = 166/479 (34%), Positives = 211/479 (44%), Gaps = 61/479 (12%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M+EAD P KLFIGGLN +T+EK LKA FGK+G I +V L+KDR T+KSRGFAF+TFE+PA
Sbjct: 1   MVEADHPGKLFIGGLNRETNEKMLKAVFGKHGPISEVLLIKDR-TSKSRGFAFITFENPA 59

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKS-SRWVPPTPG---SGSRSRFSHRTRGGGS 116
           DAK AA+DMNG  L GKAI V Q  KP+F+S  R  PP      S S S  S R   GG+
Sbjct: 60  DAKNAAKDMNGTSLHGKAIKVEQAKKPSFQSGGRRRPPASSRNRSPSGSLRSARGSSGGT 119

Query: 117 SPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGC 176
               P  +G  DDG GY     +   R  +P KRGP  R    PP K++ PS++A S   
Sbjct: 120 RGWLPSHEGHLDDG-GYTPDLKMSYSRGLIPVKRGPSSRS-GGPPPKKSAPSAVARS-NS 176

Query: 177 GMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSG 236
            M  + P    ++ Y G+ PR            R++++      M  +       DG   
Sbjct: 177 WMGSQGPMSQRRENY-GVPPR------------RATISSWRNDRMSTRHDGYATNDGNH- 222

Query: 237 PRVREPLPPCRDPGDFVPALRDY--------------SRRYYGHSSVPDYRPLRGDGNQN 282
                  P C++  D+ P  R Y              SR Y  H S  + R        +
Sbjct: 223 -------PSCQETRDYAPPSRGYAYRDNGHSNRDEHSSRGYRNHRSSRETRDYAPPSRGH 275

Query: 283 GYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTP-PSYGGGCRYEEYQGNSPDACS 341
            YR   H   D      YR    S      A P  G     YG   R+E Y     +  S
Sbjct: 276 AYRDYGHSRRDESYSRGYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPS 335

Query: 342 EGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHS 401
              + +  P     AY RD+    +S     SS GYS  D YGE        GR    H 
Sbjct: 336 SRETRDYAPPHRDYAY-RDY---GHSSWDEHSSRGYSYHDGYGEA------LGRDHSEHL 385

Query: 402 GGRN--SSSNSYGQSHHY-GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHD 457
            G +   +   YG SH      G    Y G +  A S  R       GRS ++YS   D
Sbjct: 386 SGSSYRDALQRYGTSHGAPPARGPRMSYGGSTCHAYSNTRD----RYGRSWESYSSCGD 440



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 121/467 (25%), Positives = 164/467 (35%), Gaps = 77/467 (16%)

Query: 648  DAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSS--QSNRYGGG 705
            DA +   D +G S  +G   + E+ +     +  G R P A S     S   +S R   G
Sbjct: 60   DAKNAAKDMNGTS-LHGKAIKVEQAKKPSFQSG-GRRRPPASSRNRSPSGSLRSARGSSG 117

Query: 706  GRYEEYRGHSLDANSGGRSPD---TYSRG--HDSSSQSDHYGGGGRSLDANSSGRLPDAY 760
            G       H    + GG +PD   +YSRG        S   GG      A S+    +++
Sbjct: 118  GTRGWLPSHEGHLDDGGYTPDLKMSYSRGLIPVKRGPSSRSGGPPPKKSAPSAVARSNSW 177

Query: 761  SGGHDS-SSRSHRYGGGGR---YEEYRGRSLDANSGGRSPNAYSGGHNSSSRND---PCR 813
             G     S R   YG   R      +R   +     G + N   G H S        P  
Sbjct: 178  MGSQGPMSQRRENYGVPPRRATISSWRNDRMSTRHDGYATN--DGNHPSCQETRDYAPPS 235

Query: 814  GGGRYEENRGHSLDANSGGHSPNAYSGGRDS-SSNSY---DRSHRYGGGGH--------- 860
             G  Y +N GHS   N   HS   Y   R S  +  Y    R H Y   GH         
Sbjct: 236  RGYAYRDN-GHS---NRDEHSSRGYRNHRSSRETRDYAPPSRGHAYRDYGHSRRDESYSR 291

Query: 861  -YEEYRG----RSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHY--GRGGCY 913
             Y  +R     R +   SRG     +      E+YSRG  +  +S    D+    R   Y
Sbjct: 292  GYRNHRSSRETREYAPPSRGHGYRDYGHSRRHESYSRGYRNHPSSRETRDYAPPHRDYAY 351

Query: 914  EEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRD--SSIKSY 971
             +Y            G +S +    R + Y  G  Y E  G     H  G     +++ Y
Sbjct: 352  RDY------------GHSSWDEHSSRGYSYHDG--YGEALGRDHSEHLSGSSYRDALQRY 397

Query: 972  GLS-DRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRS--------DRYSRGRDRVGRPD 1022
            G S       G    Y GS   AYS   DR    YGRS        D +   R+ V R D
Sbjct: 398  GTSHGAPPARGPRMSYGGSTCHAYSNTRDR----YGRSWESYSSCGDFHYCDREHVCRKD 453

Query: 1023 RGLPLPMETGSPPLHDSYSRSG--CRVPRGGGRQGGRFERGEGRSRY 1067
            +  P  +    P   ++Y  S     +  GG     R E+G+  SRY
Sbjct: 454  QRNPPSLGRVLPDPREAYGSSSYVASIVDGG---ESRSEKGDS-SRY 496


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score =  174 bits (441), Expect = 4e-43
 Identities = 261/1040 (25%), Positives = 354/1040 (34%), Gaps = 150/1040 (14%)

Query: 100  GSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWAS 159
            GSGSR    H  +G GS  ++ PS  R   G G++         +     RG    H+ S
Sbjct: 287  GSGSRQSLGHGRQGSGS--RQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRG----HYES 340

Query: 160  --------PPHKRAT---------PSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGP 202
                      H+  +          S   HS   G  G     +   G  G   R+ +  
Sbjct: 341  GSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSY 400

Query: 203  PHKRAVPRSSLARIGGSGMPGKAPAVWGQDGY------SGPRVREPLPPCRDPGDFVPAL 256
                +  R S  R   S   G++P   GQ G       S  +           G +V   
Sbjct: 401  GQHESASRHSSGRGQHSSGSGQSPG-HGQRGSGSGQSPSSGQHGTGFGRSSSSGPYVSG- 458

Query: 257  RDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPV 316
              YS  +  H S  ++    G        G    +  H S+       +  G   G++  
Sbjct: 459  SGYSSGFGHHESSSEHS--SGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSS 516

Query: 317  WGTPPSYG----GGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSS 372
            +G   S      G  R+    G SP   S GR             S  + P  Y  GRSS
Sbjct: 517  YGQHGSGSRQSLGHSRHGSGSGQSPSP-SRGRHESG------SRQSSSYGPHGYGSGRSS 569

Query: 373  SSNGY-----------------SRSDRYGEEG-------CYEEYRGRSPDAHSGGRNSSS 408
            S   Y                  +S  YG+ G        + ++   S  + S G++ ++
Sbjct: 570  SRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGAT 629

Query: 409  NSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGG 468
            +    SH   G G  +     S   + G  S  + SRGR    +  GH SS      G G
Sbjct: 630  SGQSSSHGQHGSGSSQS----SRYGQQGSGSGQSPSRGRHGSDF--GHSSSYGQHGSGSG 683

Query: 469  GRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPD 528
                     S+   S G   +  SG   +S +S       H    R H   + SG  S  
Sbjct: 684  WSSSNGPHGSVSGQSSGFGHK--SGSGQSSGYSQHGSGSSHSSGYRKHG--SRSGQSSRS 739

Query: 529  THSGGHSSSSNSYGQ----SHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNR 584
               G  S  S+SYGQ    SH+  G GR      S   HS        S GH SSS    
Sbjct: 740  EQHGSSSGLSSSYGQHGSGSHQSSGHGRQ----GSGSGHSPSRVRHGSSSGH-SSSHGQH 794

Query: 585  YGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGG 644
              G  C          ++S G   +    G  S    H  G G  Y ++   S   +S G
Sbjct: 795  GSGTSC----------SSSCGHYES--GSGQASGFGQHESGSGQGYSQHGSASGHFSSQG 842

Query: 645  R-----SPDAYSGGHD-SSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQ 698
            R        + SG HD SSGQS+ YG      ++      A+  GR     SG   S   
Sbjct: 843  RHGSTSGQSSSSGQHDSSSGQSSSYG------QHESASHHASGRGRHG---SGSGQSPGH 893

Query: 699  SNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPD 758
              R  G G+   Y  H    +  GRS    S G   S      G G +S    SSG    
Sbjct: 894  GQRGSGSGQSPSYGRH---GSGSGRSS---SSGRHGSGSGQSSGFGHKSSSGQSSGYTQH 947

Query: 759  AYSGGHDSSSRSH--RYGGGGRYEEYRGRSLDANS-----GGRSPNAYSGGHNSSSRNDP 811
                GH SS   H  R G   R E++   S  ++S      G   +   G H S S   P
Sbjct: 948  GSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSP 1007

Query: 812  CRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGG-GHYEEYRGRSHD 870
                GR+    G      S  + P     G  SS   Y+    +  G GH E   G+S  
Sbjct: 1008 SPSRGRHGSGSG-----QSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSG 1062

Query: 871  THSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGL 930
                G S   HS  H     + G+ S    +G S   G+   + ++   S  + G GR  
Sbjct: 1063 YGQHG-SSSGHSSTHGQHGSTSGQSSSCGQHGASS--GQSSSHGQHGSGSSQSSGYGRQG 1119

Query: 931  NSSNNSHGRSHRYGGGGRYEEYRGPSPDAH--SGGRDSSIKSYGLS-DRYGGGGHYEEYQ 987
            + S  S G   R G G R    + PS   H    GR SS   +G       G GH+E   
Sbjct: 1120 SGSGQSPGHGQR-GSGSR----QSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSS 1174

Query: 988  GSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSGCRV 1047
            G      S  + +  +  G S  Y +   R G+  RG      +GS   H     SG R 
Sbjct: 1175 GQ-----SSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSS-HYGQHGSGSRQ 1228

Query: 1048 PRGGGRQGGRFERGEGRSRY 1067
              G GRQG        R R+
Sbjct: 1229 SSGHGRQGSGSGHSPSRGRH 1248



 Score =  169 bits (429), Expect = 1e-41
 Identities = 269/1055 (25%), Positives = 353/1055 (33%), Gaps = 145/1055 (13%)

Query: 100  GSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWAS 159
            GSGSR    H   G GS     PS+GR + G   +  +    Y +     RGP       
Sbjct: 521  GSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGH 580

Query: 160  PPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGS 219
                    S    S G G  G +   S   G  G      +G         ++  +    
Sbjct: 581  SSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHGST----SGQSSSCGQHGATSGQSSSH 636

Query: 220  GMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRG-- 277
            G  G   +   + G  G    +     R   DF      +S  Y  H S   +    G  
Sbjct: 637  GQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDF-----GHSSSYGQHGSGSGWSSSNGPH 691

Query: 278  ---DGNQNGY-----RGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGG-GCR 328
                G  +G+      G+   Y+ H S  S+    + +G   G +       S  G    
Sbjct: 692  GSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQHGSSSGLSSS 751

Query: 329  YEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSS---SSNGYSRSDRYGE 385
            Y ++   S  +   GR                HSP     G SS   SS+G   S     
Sbjct: 752  YGQHGSGSHQSSGHGRQGSG----------SGHSPSRVRHGSSSGHSSSHGQHGSGTSCS 801

Query: 386  EGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSR 445
              C   Y   S  A   G++ S +  G S H    G +   +GR         S+  H  
Sbjct: 802  SSC-GHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSS-QGRHGSTSGQSSSSGQHDS 859

Query: 446  GRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLD----ANSGGCSPE--AYSGGHDNSS 499
                 +  G H+S+S      G GR+    G+S       +  G SP    +  G   SS
Sbjct: 860  SSGQSSSYGQHESASHH--ASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSS 917

Query: 500  WSDRYGVGGHYEENRGH-SLDANSGGRSPDTHSGGHSSSSNSYG----QSHRYGGEGRYE 554
             S R+G G       GH S    S G +      GHSSS   +G    QS R    G   
Sbjct: 918  SSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSS 977

Query: 555  YRGRSHDAHSGGCSADAYSGGHDSSSQSN------RYGGGGCYEEYRG--RSLDANSGGR 606
                S+  H  G       G H S S  +      R+G G       G  RS    S  R
Sbjct: 978  GSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSR 1037

Query: 607  SPNAYSGGHDSSSWSHRYGGGGRYEEY--RGRSLDANS-----GGRSPDAYSGGHD--SS 657
             P     GH SS   HR    G+   Y   G S   +S     G  S  + S G    SS
Sbjct: 1038 GPYESGSGH-SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASS 1096

Query: 658  GQSNCYG----------GGGRYEEYRGRLL---DANSGGRSPDAYS---GGHDSSSQSNR 701
            GQS+ +G          G GR     G+        SG R   +Y     G   SS S +
Sbjct: 1097 GQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQ 1156

Query: 702  YGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYS 761
            +G G    E  G     +S G+S  +YS+    S  S  YG  G     +S G    + S
Sbjct: 1157 HGSG--LGESSGFGHHESSSGQS-SSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSS 1213

Query: 762  GGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEEN 821
            G   SSS   ++G G R     GR    +  G SP+                  GR+   
Sbjct: 1214 G---SSSHYGQHGSGSRQSSGHGR--QGSGSGHSPSR-----------------GRHGSG 1251

Query: 822  RGHSLDANSGGHSPNAYSGGRDSSSNSYD-RSHRYGGGGHYEEYRGRS--HDTHSRGRSP 878
             GH     S  H  +    GR SS   Y+ RS      G +E   G S  +  H  G   
Sbjct: 1252 LGH-----SSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGH 1306

Query: 879  DAHSGDH-YTEAYSRGRDSFSNSYGRSDHYG-RGGCYEEYQGRSPNAYGGG----RGLNS 932
                G H  T   S   D   +S G+S  YG RG    +  G   +  G G    RG + 
Sbjct: 1307 FCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHG 1366

Query: 933  SNNSHGRS---HRYGGGGRYEEYRGPSPDAHSGG----RDSSIKSYGLSDRYGGGGHYEE 985
            S + H  S   H  G G      R  S    S G      SS +S G +    G GH   
Sbjct: 1367 SGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSS 1426

Query: 986  YQ--GSLPDAYS-----GDHDRSSNSYGR---SDRYSRGRDRVGRPDRGLPLPME----- 1030
            Y+  GS     S     G    SS+SYG+     R S G  + G      P P       
Sbjct: 1427 YEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGS 1486

Query: 1031 -TGSPPLHDSY-SRSGCRVPRGGGRQGGRFERGEG 1063
             +G    +  Y S SG    RG    G     G G
Sbjct: 1487 GSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLG 1521



 Score =  167 bits (424), Expect = 4e-41
 Identities = 270/1038 (26%), Positives = 362/1038 (34%), Gaps = 150/1038 (14%)

Query: 100  GSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPR---H 156
            GSGSR    H   G GS     PS+GR   G G +  +  +   +     RGP      H
Sbjct: 987  GSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGH 1046

Query: 157  WASPPHKRATP----------SSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGP-PHK 205
             +   H+ +            SS  HS   G  G     S   G  G    + +    H 
Sbjct: 1047 SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHG 1106

Query: 206  RAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYG 265
                +SS     GSG  G++P   GQ G SG R + P       G    +         G
Sbjct: 1107 SGSSQSSGYGRQGSGS-GQSPG-HGQRG-SGSR-QSPSYGRHGSGSGRSSSSGQHGSGLG 1162

Query: 266  HSSVPDYRPLRGDGNQNGYR------GRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGT 319
             SS   +      G  + Y       G    Y  H S+       + +G   G++  +G 
Sbjct: 1163 ESSGFGHHE-SSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYG- 1220

Query: 320  PPSYGGGCRYEEYQGN----SPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSN 375
               +G G R     G     S  + S GR    L       +S  H       GRSSS  
Sbjct: 1221 --QHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGL------GHSSSHGQHGSGSGRSSSRG 1272

Query: 376  GY-SRSDRY----------GEEGCYEEYRGRSPDAHSGGRNSSSN-----------SYGQ 413
             Y SRS             G    Y ++   S    S G++ S++           S GQ
Sbjct: 1273 PYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQ 1332

Query: 414  SHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEE 473
            S  YG  G        S   R G  S  + SRGR     SG   SSS+    G G  +  
Sbjct: 1333 SSSYGHRGSGSSQS--SGYGRHGAGSGQSPSRGRHG---SGSGHSSSYGQH-GSGSGWSS 1386

Query: 474  YQGRSLDANSGGCSPEAYSGGHDNSSWSD----RYGVG-GHYEENRGHSLDANSGGRSPD 528
              GR    +  G    +  G H++SSW      ++G G GH      H   + SG  S  
Sbjct: 1387 SSGR----HGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHG--SRSGQSSRG 1440

Query: 529  THSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDS----SSQSNR 584
               G  S SS+SYGQ     G G  +  G        G S     G H S    SS  + 
Sbjct: 1441 ERHGSSSGSSSSYGQH----GSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSP 1496

Query: 585  YGGGGCYEEYRG--RSLDANSGGRSPNAYSGGHDSSSWSHRYGGG-----GRYEEYRGRS 637
            YG G  +   RG   S  ++S G        G  S    H    G     G++    G+S
Sbjct: 1497 YGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQS 1556

Query: 638  LDANSGGRSPDAYS--GGHDS-SGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYS---G 691
                  G S    S  G H S S QS+ YG  G             SG R   +Y     
Sbjct: 1557 SSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGS 1616

Query: 692  GHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDAN 751
            G   SS S ++G G    E  G     +S G+S  +YS+    S  S  YG  G     +
Sbjct: 1617 GSGRSSSSGQHGSG--LGESSGFGHHESSSGQS-SSYSQHGSGSGHSSGYGQHGSRSGQS 1673

Query: 752  SSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDP 811
            S G   + +     SSSR  ++G G R     GR    +  G+SP+              
Sbjct: 1674 SRG---ERHGSSSRSSSRYGQHGSGSRQSSGHGR--QGSGSGQSPSR------------- 1715

Query: 812  CRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYD-RSHRYGGGGHYEEYRGRS-- 868
                GR+    GH     S  H  +    GR SS   Y+ RS      G +E   G S  
Sbjct: 1716 ----GRHGSGLGH-----SSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSA 1766

Query: 869  HDTHSRGRSPDAHSGDH-YTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGG 927
            +  H  G       G H  T   S   D   +S G+S  +G+ G     Q  S    G G
Sbjct: 1767 YSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSS-QSSSYGQQGSG 1825

Query: 928  RGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQ 987
             G + S   HG     G    Y ++   S  + S GR  S      S +  G GH+E   
Sbjct: 1826 SGQSPSRGRHGSGS--GHSSSYGQHGSGSGWSSSSGRHGS-----GSGQSSGFGHHESSS 1878

Query: 988  GSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSGCRV 1047
                   S  + +  +  G S  Y +   R G+  RG      +GS   +  +  SG R 
Sbjct: 1879 WQ-----SSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQHG-SGSRQ 1932

Query: 1048 PRGGGRQGGRFERGEGRS 1065
              G G+ G     G G+S
Sbjct: 1933 SLGHGQHGS----GSGQS 1946



 Score =  165 bits (418), Expect = 2e-40
 Identities = 272/1079 (25%), Positives = 368/1079 (34%), Gaps = 181/1079 (16%)

Query: 100  GSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGP---PPRH 156
            GSGSR    H   G GS     PS+GR   G G +  +  +   +     RGP      H
Sbjct: 1457 GSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSH 1516

Query: 157  WASPPHKRATP----------SSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGP-PHK 205
             +   H+ +            SS  HS   G  G     S   G  G    + +    H 
Sbjct: 1517 SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHG 1576

Query: 206  RAVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYG 265
                +SS     GSG  G++P   GQ G SG R + P       G    +         G
Sbjct: 1577 SGSSQSSGYGRQGSGS-GQSPG-HGQRG-SGSR-QSPSYGRHGSGSGRSSSSGQHGSGLG 1632

Query: 266  HSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPS--- 322
             SS        G G+     G+   Y+ H S   +      +G   G +       S   
Sbjct: 1633 ESS--------GFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSR 1684

Query: 323  -------YGGGCRYEEYQGN----SPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRS 371
                   +G G R     G     S  + S GR    L       +S  H       GRS
Sbjct: 1685 SSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGL------GHSSSHGQHGSGSGRS 1738

Query: 372  SSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQ-SHHYGGEGRYEEYRGRS 430
            SS   Y    R G    + ++   S      G +S+ + +G  S H+  +G++    G+S
Sbjct: 1739 SSRGPYE--SRSGHSSVFGQHESGS------GHSSAYSQHGSGSGHFCSQGQHGSTSGQS 1790

Query: 431  HEARSGGRST-DAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPE 489
                  G ST  + S G+     SG   SSS+     G G+    +GR    +    S  
Sbjct: 1791 STFDQEGSSTGQSSSHGQHG---SGSSQSSSYGQQGSGSGQSPS-RGRHGSGSGHSSSYG 1846

Query: 490  AYSGGHDNSSWSDRYGVG-------GHYE----ENRGHSLDANSGGRSPDTHSGGHSSSS 538
             +  G   SS S R+G G       GH+E    ++ G++   +  G S      G  S  
Sbjct: 1847 QHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQ 1906

Query: 539  NSYGQSH--------RYGGEGRYEYRGRSHDAHSGGC------SADAYSGGHDSSSQSNR 584
            +S G+ H         YG  G    +   H  H  G       S   +  G   SS    
Sbjct: 1907 SSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGP 1966

Query: 585  YGGGGCYEEYRG---------------RSLDANSGGRSPNAYSGGHDSSSWSHRYGGG-- 627
            YG G  +   RG                S    S G   +  S GH S+   H    G  
Sbjct: 1967 YGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQS 2026

Query: 628  ---GRYEEYRGRSLDANSGGRSPDAYSG-GHDSSGQSNCYGGGGRYEEYRGRLLDANSGG 683
               G++    G+S      G      SG G   SG     G G R            SG 
Sbjct: 2027 SSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQR-----------GSGS 2075

Query: 684  RSPDAYS---GGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDH 740
            R   +Y     G   SS S ++G G    E  G     +S G+S  +YS+    S  S  
Sbjct: 2076 RQSPSYGRHGSGSGRSSSSGQHGPG--LGESSGFGHHESSSGQS-SSYSQHGSGSGHSSG 2132

Query: 741  YGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNA-- 798
            YG  G     +S G    + SG   SSSR  ++G G R     GR    +  G SP+   
Sbjct: 2133 YGQHGSRSGQSSRGERHGSSSG---SSSRYGQHGSGSRQSSGHGR--QGSGSGHSPSRGR 2187

Query: 799  -YSGGHNSSSRNDPCRGGGR------YEENRGHSL---DANSGGHSPNAYSGGRDSSSNS 848
              SG  +SSS      G GR      YE   GHS       SG    +AYS     S + 
Sbjct: 2188 HGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHF 2247

Query: 849  YDRSHRYGGGGHYEEY--------RGRSHDTHSRGRSPDAHSGDHYT---EAYSRGR--- 894
              +       G    +        +  SH  H  G S  +  G   +   ++ SRGR   
Sbjct: 2248 CSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGS 2307

Query: 895  -DSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRY-------GGG 946
                S+SYG+   +G G  +    GR  +  G   G     +S  +S  Y       G  
Sbjct: 2308 GSGHSSSYGQ---HGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHS 2364

Query: 947  GRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYG 1006
              YE++   S  +  G R  S  S G S  YG  G      GS      G H   S   G
Sbjct: 2365 SSYEQHGSRSGQSSRGERHGS--SSGSSSSYGQHG-----SGSRQSLGHGQHGSGS---G 2414

Query: 1007 RSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRS 1065
            +S   SRGR   G        P  +GS      +S S      G G   G   R E RS
Sbjct: 2415 QSPSPSRGRHGSGSGQSSSYSPYGSGS-----GWSSSRGPYESGSGHSSGLGHR-ESRS 2467



 Score =  160 bits (405), Expect = 6e-39
 Identities = 232/875 (26%), Positives = 305/875 (34%), Gaps = 131/875 (14%)

Query: 265  GHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYG 324
            GHSS        G G++    G+   Y  H S   +      +G   G +   G   +  
Sbjct: 1985 GHSS--------GLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHGASS 2036

Query: 325  GGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYG 384
            G       Q +S      G S  +        Y R  S    S G     +G  +S  YG
Sbjct: 2037 G-------QSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQRGSGSRQSPSYG 2082

Query: 385  EEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYR----GRSHEARSG--GR 438
              G     R  S   H  G   SS   G  HH    G+   Y     G  H +  G  G 
Sbjct: 2083 RHGSGSG-RSSSSGQHGPGLGESS---GFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGS 2138

Query: 439  STDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNS 498
             +   SRG    + SG   SSS     G G R     GR    +    S   +  G  +S
Sbjct: 2139 RSGQSSRGERHGSSSG---SSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHS 2195

Query: 499  SWSDRYGVG-------GHYEENRGHSL-----DANSGGRSPDTHSG---GHSSSSNSYG- 542
            S   ++G G       G YE   GHS      ++ SG  S  +  G   GH  S   +G 
Sbjct: 2196 SSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGS 2255

Query: 543  ---QSHRYGGEGRYEYRGRSHDAHSGGCSADAYSG----GHDSSSQSNRYGGGGCYEEYR 595
               QS  +  EG    +  SH  H  G S  +  G    G   S    R+G G  +    
Sbjct: 2256 TSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSY 2315

Query: 596  GR---------SLDANSGGRSPNAYSGGHDSSSWS------HRYGGG--GRYEEYRGRSL 638
            G+         S   +  G   ++  G H+SSSW       H  G G    YE++  RS 
Sbjct: 2316 GQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSG 2375

Query: 639  DANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDS--- 695
             ++ G R   + SG   S GQ   +G G R     G+    +  G+SP    G H S   
Sbjct: 2376 QSSRGERHGSS-SGSSSSYGQ---HGSGSRQSLGHGQ--HGSGSGQSPSPSRGRHGSGSG 2429

Query: 696  -SSQSNRYGGG-------GRYEEYRGHSLDA----NSGGRSPDTYSRGHDSSSQSDHYGG 743
             SS  + YG G       G YE   GHS       +  G+S      G  S   S H   
Sbjct: 2430 QSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQH 2489

Query: 744  GGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGH 803
            G  S  ++S G+      G     S SH   G G  +   G     +  G+SP    G  
Sbjct: 2490 GSTSGQSSSCGQ-----HGASSGQSSSHGQHGSGSSQS-SGYGRQGSGSGQSPG--HGQR 2541

Query: 804  NSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGG-GHYE 862
             S SR  P  G       R  S   +  G   ++  G  +SSS       ++G G GH  
Sbjct: 2542 GSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSS 2601

Query: 863  EY--RGRSHDTHSRGRSPDAHSGD--HYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQG 918
             Y   G      SRG    + SG   HY +  S  R S  + +GR    G G      +G
Sbjct: 2602 GYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQS--SGHGRQ---GSGSGQSPSRG 2656

Query: 919  RSPNAYGGGRGLNSSNNSHGR-SHRYGGGGRYEEYRGPSP--DAHSGGRDSSIKSYGLSD 975
            R    +G G G +SS+  HG  S R    G YE   G S     H  G   S  S   S 
Sbjct: 2657 R----HGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESG---SGHSSAYSQ 2709

Query: 976  RYGGGGHY--EEYQGSLPDAYS-----GDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLP 1028
               G GH+  +   GS     S     G     S+SYG     S      GR   G    
Sbjct: 2710 HGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQS 2769

Query: 1029 METGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEG 1063
            +  G        S S  +   G G+  G  + G G
Sbjct: 2770 LSHGRHGSGSGQSSSYGQHGSGSGQSSGYSQHGSG 2804



 Score =  156 bits (394), Expect = 1e-37
 Identities = 243/965 (25%), Positives = 330/965 (34%), Gaps = 132/965 (13%)

Query: 100  GSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPR---H 156
            GSGSR    H   G GS     PS+GR   G G +  +  +   +     RGP      H
Sbjct: 1927 GSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGH 1986

Query: 157  WASPPHKRATP----------SSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKR 206
             +   H+ +            SS  HS   G  G A   S   G  G      +G     
Sbjct: 1987 SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHGAS----SGQSSSH 2042

Query: 207  AVPRSSLARIGGSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGH 266
                S  ++  G G  G         G  G   R+     R       + R  S   +G 
Sbjct: 2043 GQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSG---SGRSSSSGQHG- 2098

Query: 267  SSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTP-PSYGG 325
               P      G G+     G+   Y+ H S   +      +G   G +        S G 
Sbjct: 2099 ---PGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGS 2155

Query: 326  GCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSP---KAYSGGRSSSSNGY--SRS 380
              RY ++   S  +   GR                HSP   +  SG   SSS+G   S S
Sbjct: 2156 SSRYGQHGSGSRQSSGHGRQGSG----------SGHSPSRGRHGSGSGHSSSHGQHGSGS 2205

Query: 381  DRYGEEGCYEEYRGRSP--DAHSGGRNSSSNSYGQ----SHHYGGEGRYEEYRGRSHEAR 434
             R    G YE   G S     H  G   SS +Y Q    S H+  +G++    G+S    
Sbjct: 2206 GRSSSRGPYESRSGHSSVFGQHESGSGHSS-AYSQHGSGSGHFCSQGQHGSTSGQSSTFD 2264

Query: 435  SGGRST-DAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSG 493
              G ST  + S G+     SG   SSS+     G G+    +GR    +    S   +  
Sbjct: 2265 QEGSSTGQSSSHGQHG---SGSSQSSSYGQQGSGSGQSPS-RGRHGSGSGHSSSYGQHGS 2320

Query: 494  GHDNSSWSDRYGVG-------GHYE----ENRGHSLDANSGGRSPDTHSGGHSSSSNSYG 542
            G   SS S R+G G       GH+E    ++ G++   +  G S      G  S  +S G
Sbjct: 2321 GSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRG 2380

Query: 543  QSH--------RYGGEGRYEYRGRSHDAHSGGC------SADAYSGGHDSSSQSNRYGGG 588
            + H         YG  G    +   H  H  G       S   +  G   SS  + YG G
Sbjct: 2381 ERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSG 2440

Query: 589  GCYEEYRG--RSLDANSGGRSPNAYSGGHDSSSWSHRYGGG-----GRYEEYRGRSLDAN 641
              +   RG   S   +S G        G  S    H    G     G++    G+S    
Sbjct: 2441 SGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCG 2500

Query: 642  SGGRSPDAYS--GGHDS-SGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYS---GGHDS 695
              G S    S  G H S S QS+ YG  G             SG R   +Y     G   
Sbjct: 2501 QHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGR 2560

Query: 696  SSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGR 755
            SS S ++G G    E  G     +S G+S  +YS+    S  S  YG  G     +S G 
Sbjct: 2561 SSSSGQHGSG--LGESSGFGHHESSSGQS-SSYSQHGSGSGHSSGYGQHGSRSGQSSRGE 2617

Query: 756  LPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGG 815
               + SG   SSS   ++G G R     GR    +  G+SP+                  
Sbjct: 2618 RHGSSSG---SSSHYGQHGSGSRQSSGHGR--QGSGSGQSPSR----------------- 2655

Query: 816  GRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYD-RSHRYGGGGHYEEYRGRS--HDTH 872
            GR+    GH     S  H  +    GR SS   Y+ R       G +E   G S  +  H
Sbjct: 2656 GRHGSGLGH-----SSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQH 2710

Query: 873  SRGRSPDAHSGDH-YTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLN 931
              G       G H  T   S   D   +S G+S  YG  G     Q      +G G G +
Sbjct: 2711 GSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSS-QSSGYGRHGAGSGQS 2769

Query: 932  SSNNSH----GRSHRYG-GGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGG--GGHYE 984
             S+  H    G+S  YG  G    +  G S      G+D      G S+  GG  G ++ 
Sbjct: 2770 LSHGRHGSGSGQSSSYGQHGSGSGQSSGYSQHGSGSGQDGYSYCKGGSNHDGGSSGSYFL 2829

Query: 985  EYQGS 989
             +  S
Sbjct: 2830 SFPSS 2834



 Score =  148 bits (374), Expect = 2e-35
 Identities = 260/1067 (24%), Positives = 340/1067 (31%), Gaps = 156/1067 (14%)

Query: 100  GSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWAS 159
            GSGSR    H  +G GS   + PS+GR   G G++         +     RGP       
Sbjct: 1693 GSGSRQSSGHGRQGSGSG--QSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGH 1750

Query: 160  PPHKRATPSSLAHSVGCGMRGKAP---TVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARI 216
                    S   HS      G         GQ G +  Q   +     +        +  
Sbjct: 1751 SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTF----DQEGSSTGQSSSH 1806

Query: 217  GGSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDY---- 272
            G  G      + +GQ G    +   P       G        +S  Y  H S   +    
Sbjct: 1807 GQHGSGSSQSSSYGQQGSGSGQ--SPSRGRHGSGS------GHSSSYGQHGSGSGWSSSS 1858

Query: 273  -RPLRGDGNQNGYRGRDHE------YTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGG 325
             R   G G  +G+   +        YT H S   +    + +G   G +           
Sbjct: 1859 GRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSS---------- 1908

Query: 326  GCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGE 385
              R E++  +S  + S G+        L        S ++ S  R    +G  +S  YG 
Sbjct: 1909 --RGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGP 1966

Query: 386  EGC---YEEYRG--RSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRG-RSHEARSGGRS 439
             G    +   RG   S   HS G     +  GQS  YG  G    +         + G+S
Sbjct: 1967 YGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQS 2026

Query: 440  TDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGC----SPE--AYSG 493
            +     G S    S      S S    G GR     G+S      G     SP    +  
Sbjct: 2027 SSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGS 2086

Query: 494  GHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRY 553
            G   SS S ++G G       GH  +++SG  S  +  G  S  S+ YGQ   +G     
Sbjct: 2087 GSGRSSSSGQHGPGLGESSGFGHH-ESSSGQSSSYSQHGSGSGHSSGYGQ---HGSRSGQ 2142

Query: 554  EYRGRSHDAHSGGCSADAYSG-GHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYS 612
              RG  H + SG  S     G G   SS   R G G  +   RGR           +   
Sbjct: 2143 SSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGR-----------HGSG 2191

Query: 613  GGHDSSSWSHRYGGG-----GRYEEYRGRSL---DANSGGRSPDAYSGGHDSSGQSNCYG 664
             GH SS   H  G G     G YE   G S       SG     AYS  H S     C  
Sbjct: 2192 SGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQ-HGSGSGHFCSQ 2250

Query: 665  GGGRYEEYRGRLLDANSGGRSPDAYSGGHDS-SSQSNRYG---GGGRYEEYRGHSLDANS 720
            G       +    D         +  G H S SSQS+ YG    G      RG     + 
Sbjct: 2251 GQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSG 2310

Query: 721  GGRSPDTYSRGHDSSSQSDHYGGGG---------RSLDANSSGRLPDAYSGGHDSSSRSH 771
               S   +  G   SS S  +G G           S    SSG        GH SS   H
Sbjct: 2311 HSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQH 2370

Query: 772  --RYGGGGRYEEYRGRSLDANSGGRSPNAYS-----GGHNSSSRNDPCRGGGRYEENRGH 824
              R G   R E +   S  ++S G+  +        G H S S   P    GR+    G 
Sbjct: 2371 GSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQ 2430

Query: 825  SLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGG-GHYEEYRGRSHDTHSRGRSPDAHSG 883
            S       +SP     G  SS   Y+    +  G GH E   G+S      G S   HS 
Sbjct: 2431 S-----SSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSS-SGHSS 2484

Query: 884  DHYTEAYSRGRDSFSNSYG-----------------RSDHYGRGGCYEEYQGRSP----- 921
             H     + G+ S    +G                 +S  YGR G      G+SP     
Sbjct: 2485 THGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQG---SGSGQSPGHGQR 2541

Query: 922  ------------NAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIK 969
                        +  G GR  +S  +  G      G G +E   G S      G  S   
Sbjct: 2542 GSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGES-SGFGHHESSSGQSSSYSQHGSGSGHS 2600

Query: 970  S-YGLSDRYGGGGHYEEYQGSLPDAYS-----GDHDRSSNSYGRSDRYSRGRDRVGRPDR 1023
            S YG      G     E  GS   + S     G   R S+ +GR    S      GR   
Sbjct: 2601 SGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGS 2660

Query: 1024 GLPLPMETGSPPLHDSYS-RSGCRVP----RGGGRQGGRFERGEGRS 1065
            GL     + S   H S S RS  R P     G     G+ E G G S
Sbjct: 2661 GLG---HSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHS 2704



 Score =  143 bits (360), Expect = 1e-33
 Identities = 193/783 (24%), Positives = 274/783 (34%), Gaps = 95/783 (12%)

Query: 355  DAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYE----EYRGRSPDAH-SGGRNSSSN 409
            D+YSR+       G  S S     + D  G+   Y      Y  ++ D+H S GR    +
Sbjct: 138  DSYSRNVRGSLKPGTESISRRLSFQRDFSGQHNSYSGQSSSYGEQNSDSHQSSGRGQCGS 197

Query: 410  SYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGG 469
              GQS +YG  G        +    SG   +   S+ +S    S G+  S      G   
Sbjct: 198  GSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGY--SQHGSGSGHSS 255

Query: 470  RYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDT 529
             Y ++  RS  ++ G    E +     +SS   ++G G    ++ GH    +   +SP  
Sbjct: 256  GYGQHGSRSGQSSRG----ERHRSSSGSSSSYGQHGSGSR--QSLGHGRQGSGSRQSPSH 309

Query: 530  --------HSGGH----SSSSNSYGQSHRYGGEGRYEYRGR--SHDAHSGGCSADAYSGG 575
                    HS  H    S SS SY + H   G G+    G+  S    S G S      G
Sbjct: 310  VRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSG 369

Query: 576  HDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGG---GRYEE 632
            H SS   +    G      +  S    S     +  +  H S    H  G G   G  + 
Sbjct: 370  HSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQR 429

Query: 633  YRGRSLDANSG------GRSPDA--------YSGG---HDSSGQSNC----YGGGGRYEE 671
              G     +SG      GRS  +        YS G   H+SS + +     +G G  +  
Sbjct: 430  GSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSS 489

Query: 672  YRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRG 731
              G+    +      +       SSS   ++G G R  +  GHS   +  G+SP      
Sbjct: 490  GHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSR--QSLGHSRHGSGSGQSPSPSRGR 547

Query: 732  HDSSS-QSDHYGGGGRSLDANSSGRLPDAYSGGHDS-----SSRSHRYGGGGRYEEYRGR 785
            H+S S QS  YG  G      SS R P     GH S      SRS +  G G++    G 
Sbjct: 548  HESGSRQSSSYGPHGYG-SGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGH 606

Query: 786  SLDANSGGRSPNAYS--GGHNSSSRNDPCRG--GGRYEENRGHSLDANSGGHSPNAYSGG 841
            S      G +    S  G H ++S      G  G    ++  +    +  G SP   S G
Sbjct: 607  SSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSP---SRG 663

Query: 842  RDSSSNSYDRSH-RYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNS 900
            R  S   +  S+ ++G G  +    G       +       SG   +  YS+     S+S
Sbjct: 664  RHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHS 723

Query: 901  YGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGR-SHRYGGGGRYEEYRGPSPD- 958
             G   H  R G     Q      +G   GL+SS   HG  SH+  G GR     G SP  
Sbjct: 724  SGYRKHGSRSG-----QSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSR 778

Query: 959  ---AHSGGRDSSIKSYGLSDRYGGG-GHYEEYQGSLPDAYSGDHDRSS------------ 1002
                 S G  SS   +G         GHYE   GS   +  G H+  S            
Sbjct: 779  VRHGSSSGHSSSHGQHGSGTSCSSSCGHYE--SGSGQASGFGQHESGSGQGYSQHGSASG 836

Query: 1003 --NSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFER 1060
              +S GR    S      G+ D         G       ++    R   G G+  G  +R
Sbjct: 837  HFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQR 896

Query: 1061 GEG 1063
            G G
Sbjct: 897  GSG 899



 Score =  131 bits (329), Expect = 4e-30
 Identities = 182/668 (27%), Positives = 249/668 (37%), Gaps = 103/668 (15%)

Query: 452  YSGGHDSSSWSDCCGGGGRYEEYQ--GRSLDANSGGCSPE--AYSGGHDNSSWSDRYGVG 507
            +SG H+S S      G    + +Q  GR    +  G SP    +  G   SS +D +G G
Sbjct: 165  FSGQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGSGQSSSNDTHGSG 224

Query: 508  GHYEENRGHSLDANSGGRSPD-THSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGG 566
                ++ G S   +S G+S   +  G  S  S+ YGQ   +G       RG  H + SG 
Sbjct: 225  SG--QSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQ---HGSRSGQSSRGERHRSSSG- 278

Query: 567  CSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGG 626
                       SSS   ++G G       GR    +    S   +  G   SS   ++G 
Sbjct: 279  -----------SSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGS 327

Query: 627  GGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCY---GGGGRYEEYRGRLLDANSGG 683
            G  Y   RG      SG      +      SGQS+ Y   G G  +   +G+    ++ G
Sbjct: 328  GSSYSYSRGH---YESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQ--HGSTSG 382

Query: 684  RSPDAYSGGHDSSS-QSNRYG---GGGRYEEYRGHSLDANSGGRSPDTYSRGH---DSSS 736
            ++  + SG H SSS QS+ YG      R+   RG    ++  G+SP    RG     S S
Sbjct: 383  QA--SSSGQHGSSSRQSSSYGQHESASRHSSGRGQ--HSSGSGQSPGHGQRGSGSGQSPS 438

Query: 737  QSDHYGGGGRSLDANSSGRL--PDAYSG--GHDSSSRSHRYG------------GGGRYE 780
               H  G GRS   +SSG       YS   GH  SS  H  G            G G++ 
Sbjct: 439  SGQHGTGFGRS---SSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHG 495

Query: 781  EYRGRSLDANSGGRSPNAYS--GGHNSSSRNDPCRGGGRYEENRGHSLDANSGGH----- 833
               G+S      G S  + S  G H S SR     G  R+    G S   + G H     
Sbjct: 496  SRSGQSSRGERQGSSAGSSSSYGQHGSGSRQS--LGHSRHGSGSGQSPSPSRGRHESGSR 553

Query: 834  -----SPNAYSGGRDSSSNSYDRSHRYGGG-GHYEEYRGRSHDTHSRGRSPDAHSGDHYT 887
                  P+ Y  GR SS   Y+    +  G GH E   G+S      G S   HS  H  
Sbjct: 554  QSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHG-SSSGHSSTHGQ 612

Query: 888  EAYSRGRDSFSNSY----GRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRY 943
               + G+ S    +    G+S  +G+ G       R     G G G + S   HG    +
Sbjct: 613  HGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRY-GQQGSGSGQSPSRGRHGSD--F 669

Query: 944  GGGGRYEEYRGPSPDAHSGGRDSSI--KSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRS 1001
            G    Y ++   S  + S G   S+  +S G   + G G      Q S    YS     S
Sbjct: 670  GHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSG------QSS---GYSQHGSGS 720

Query: 1002 SNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSR--SGCRVPRGGGRQGGRFE 1059
            S+S G    Y +   R G+  R         S  L  SY +  SG     G GRQG    
Sbjct: 721  SHSSG----YRKHGSRSGQSSRS---EQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSG 773

Query: 1060 RGEGRSRY 1067
                R R+
Sbjct: 774  HSPSRVRH 781



 Score =  109 bits (272), Expect = 2e-23
 Identities = 156/588 (26%), Positives = 215/588 (36%), Gaps = 59/588 (10%)

Query: 509  HYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCS 568
            H EE      + N    S  +HS   +  ++SY ++ R   +   E   R          
Sbjct: 108  HQEEQEETEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRLSFQRD--- 164

Query: 569  ADAYSGGHDS-SSQSNRYG-GGGCYEEYRGRSLDANSGGRSPN----AYSGGHDSSSWSH 622
               +SG H+S S QS+ YG       +  GR    +  G+SPN        G  SS+ +H
Sbjct: 165  ---FSGQHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGSGQSSSNDTH 221

Query: 623  RYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYG--GGGRYEEYRGRLLDAN 680
              G G    +  G S   +S G+S   YS     SG S+ YG  G    +  RG    ++
Sbjct: 222  GSGSG----QSSGFSQHKSSSGQS-SGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSS 276

Query: 681  SGGRSPDAYSG-GHDSSSQSNRYGGGG-------RYEEYRGHSLD-ANSGGRSPDTYSRG 731
            SG  S     G G   S    R G G        R+    GHS      G  S  +YSRG
Sbjct: 277  SGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRG 336

Query: 732  HDSSSQSDHYG-GGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDAN 790
            H  S      G G   S    SSG        GH SS   H     G        S    
Sbjct: 337  HYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQH-----GSTSGQASSSGQHG 391

Query: 791  SGGRSPNAYSGGHNSSSRNDPCRG--GGRYEENRGHSLDANSGGHSPNA----YSGGRDS 844
            S  R  ++Y G H S+SR+   RG       ++ GH    +  G SP++       GR S
Sbjct: 392  SSSRQSSSY-GQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSS 450

Query: 845  SSNSYDRSHRYGGG-GHYEEYRGRS--HDTHSRGRSPDAHSGDHYTEAYSRGR-DSFSNS 900
            SS  Y     Y  G GH+E     S  +  H  G    +  G H + +    R +   +S
Sbjct: 451  SSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSS 510

Query: 901  YGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAH 960
             G S  YG+ G     Q    + +G G G  S + S G   R+  G R     G  P  +
Sbjct: 511  AGSSSSYGQHGSGSR-QSLGHSRHGSGSG-QSPSPSRG---RHESGSRQSSSYG--PHGY 563

Query: 961  SGGRDSSIKSYGLSDRYGGG-GHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVG 1019
              GR SS   Y     +  G GH E   G      S  + +  +S G S  + +     G
Sbjct: 564  GSGRSSSRGPYESGSGHSSGLGHQESRSGQ-----SSGYGQHGSSSGHSSTHGQHGSTSG 618

Query: 1020 RPDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
            +          +G    H  +  SG       G+QG    +   R R+
Sbjct: 619  QSSSCGQHGATSGQSSSHGQHG-SGSSQSSRYGQQGSGSGQSPSRGRH 665



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 164/718 (22%), Positives = 235/718 (32%), Gaps = 116/718 (16%)

Query: 100  GSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPP----- 154
            GSGSR    H  +G GS     PS+GR   G G++         +     RGP       
Sbjct: 2163 GSGSRQSSGHGRQGSGSG--HSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGH 2220

Query: 155  -----RHWASPPHKRATPSSLAHSVGCG---MRGKAPTVSGQ----DGYSGLQPRRWAGP 202
                 +H +   H  A      H  G G    +G+  + SGQ    D       +  +  
Sbjct: 2221 SSVFGQHESGSGHSSAYSQ---HGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHG 2277

Query: 203  PHKRAVPRSSLARIGGSGMPGKAPA------------VWGQ----DGYSGPRVREPLPPC 246
             H     +SS     GSG  G++P+             +GQ     G+S    R      
Sbjct: 2278 QHGSGSSQSSSYGQQGSGS-GQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 2336

Query: 247  RDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKS 306
            +  G             +GH     ++   G        G    Y  H S+       + 
Sbjct: 2337 QSSG-------------FGHHESSSWQS-SGYTQHGSGSGHSSSYEQHGSRSGQSSRGER 2382

Query: 307  YGGPCGAAPVWGTPPSYGGGCR-------YEEYQGNSPD------ACSEGRSSEALPVVL 353
            +G   G++  +G    +G G R       +    G SP           G+SS   P   
Sbjct: 2383 HGSSSGSSSSYG---QHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGS 2439

Query: 354  PDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQ 413
               +S    P  Y  G   SS    R  R G+   Y ++   S  + + G++ S++  GQ
Sbjct: 2440 GSGWSSSRGP--YESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTS--GQ 2495

Query: 414  SHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEE 473
            S   G  G          +  SG   +  + R  S    S GH         G G R   
Sbjct: 2496 SSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQR------GSGSRQSP 2549

Query: 474  YQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGG 533
              GR      G  S  + S G   S   +  G G H+E + G S   +  G S   HS G
Sbjct: 2550 SYGRH-----GSGSGRSSSSGQHGSGLGESSGFG-HHESSSGQSSSYSQHG-SGSGHSSG 2602

Query: 534  HSSSSNSYGQSHR-------------YGGEGRYEYRGRSHDAHSGGCSADAYSGGHDS-- 578
            +    +  GQS R             YG  G    +   H     G       G H S  
Sbjct: 2603 YGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGL 2662

Query: 579  --SSQSNRYGGGGCYEEYRG--RSLDANSGGRSPNAYSGGHDSSSWSHRYGGG-----GR 629
              SS   ++G G      RG   S   +S     +    GH S+   H  G G     G+
Sbjct: 2663 GHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ 2722

Query: 630  YEEYRGRSLDANSGGRSPDAYSG-GHDSSGQSNC-----YGGGGRYEEYRGRLLDANSGG 683
            +    G+S   +  G S    S  GH  SG S       +G G       GR    +   
Sbjct: 2723 HGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSLSHGRHGSGSGQS 2782

Query: 684  RSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHY 741
             S   +  G   SS  +++G G   + Y      +N  G S  +Y     SS+    Y
Sbjct: 2783 SSYGQHGSGSGQSSGYSQHGSGSGQDGYSYCKGGSNHDGGSSGSYFLSFPSSTSPYEY 2840


>gi|239752336 PREDICTED: similar to RNA binding motif protein,
           X-linked [Homo sapiens]
          Length = 138

 Score =  147 bits (370), Expect = 7e-35
 Identities = 81/141 (57%), Positives = 94/141 (66%), Gaps = 10/141 (7%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M EADR  K FIGGLN +T++KAL+A FGKYG I++V LMKD +TNKSRGFAF+TFE PA
Sbjct: 1   MGEADRLGKFFIGGLNTETNKKALEAVFGKYGQIVEVHLMKDCETNKSRGFAFITFERPA 60

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSS-RWVPPTPGSGSRSRFSHRTRGGGSSPQ 119
           DAK AARDMNGK LDGKAI V Q  KP+F+S  R  PP P S    R     RGG    +
Sbjct: 61  DAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRVLRGGRGGSGGTR 120

Query: 120 RPPSQGRPDDGRGYAGYFDLW 140
            PPS+G         G+ D W
Sbjct: 121 EPPSRG---------GHMDDW 132


>gi|239746849 PREDICTED: hypothetical protein XP_002343863 [Homo
           sapiens]
          Length = 138

 Score =  147 bits (370), Expect = 7e-35
 Identities = 81/141 (57%), Positives = 94/141 (66%), Gaps = 10/141 (7%)

Query: 1   MMEADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPA 60
           M EADR  K FIGGLN +T++KAL+A FGKYG I++V LMKD +TNKSRGFAF+TFE PA
Sbjct: 1   MGEADRLGKFFIGGLNTETNKKALEAVFGKYGQIVEVHLMKDCETNKSRGFAFITFERPA 60

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSS-RWVPPTPGSGSRSRFSHRTRGGGSSPQ 119
           DAK AARDMNGK LDGKAI V Q  KP+F+S  R  PP P S    R     RGG    +
Sbjct: 61  DAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGPPPPPRSRGPPRVLRGGRGGSGGTR 120

Query: 120 RPPSQGRPDDGRGYAGYFDLW 140
            PPS+G         G+ D W
Sbjct: 121 EPPSRG---------GHMDDW 132


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score =  145 bits (365), Expect = 3e-34
 Identities = 238/1030 (23%), Positives = 382/1030 (37%), Gaps = 170/1030 (16%)

Query: 115  GSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRAT--PSSLAH 172
            GS      SQ R D  RG +G   +   +    ++ G   RH  S  H+ ++   SS   
Sbjct: 1840 GSHHSHTTSQERSDVSRGQSGSRSV-SRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHS 1898

Query: 173  SVGCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQD 232
             VG G +   P  S   G S  Q     G  H     R S     GS       + W Q 
Sbjct: 1899 QVGQG-QSSGPRTSRNQGSSVSQDSDSQG--HSEDSERWS-----GSASRNHLGSAWEQS 1950

Query: 233  GYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYT 292
                          RD G   P      R  +GHS+            Q+G R     +T
Sbjct: 1951 --------------RD-GSRHPGSHHEDRAGHGHSA--------DSSRQSGTR-----HT 1982

Query: 293  DHPSKG---SYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEAL 349
            +  S+G   S  E  +S  G             +G   + +    +       G++S A+
Sbjct: 1983 ESSSRGQAASSHEQARSSAGE-----------RHGSHHQLQSADSSRHSGIGHGQASSAV 2031

Query: 350  PVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSD------RYGEEGCYEEYRGRSPDAHSGG 403
                     RD   + YSG ++S S G+S           G+ G +++    S    SG 
Sbjct: 2032 ---------RDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGE 2082

Query: 404  RNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSG---GHDSSS 460
             +  S S+   +      + E   G+S  + +GGR    + + +    +S    G D+  
Sbjct: 2083 SSGRSGSF--LYQVSTHEQSESTHGQSAPS-TGGRQGSHYDQAQDSSRHSASQEGQDTIR 2139

Query: 461  WSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDA 520
                   GGR   +Q +S+D +        +SG H + + S      G  + +RG S   
Sbjct: 2140 GHPGPSRGGRQGSHQEQSVDRSG-------HSGSHHSHTTSQ-----GRSDASRGQSGSR 2187

Query: 521  NSGGRSPDT--------HSGGHSSSSNSYGQSHRYGGEGRYEYRG-RSHDAHSGGCSADA 571
            ++  ++ D         HSG H   ++S+  S R+   G+ +  G R+        S D+
Sbjct: 2188 SASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDS 2247

Query: 572  YSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYS---GGHDSSSWSHRYGGGG 628
             S GH  S  S R  G      +      +  G R P ++     GH  S+ S R  G  
Sbjct: 2248 DSEGH--SEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTH 2305

Query: 629  RYEEYRG-RSLDANSGGRSP--DAYSGGHDSSGQSNCYGGGG--------RYEEYRGRLL 677
              E   G ++  ++   RS   + +   H  S  S+ + G G        R   +RG   
Sbjct: 2306 HAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRG--- 2362

Query: 678  DANSGGRSPDAYSGGHDSSSQS-NRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSS 736
              +SG ++ D+     DS +QS + +G  G +++    S    S GRS  + S  +  S+
Sbjct: 2363 --SSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVST 2420

Query: 737  QSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSP 796
                    GR+   ++ GR    +    DSS  S    G      + G S    SGGR  
Sbjct: 2421 HEQSESAHGRT-GTSTGGRQGSHHKQARDSSRHSTSQEGQDTIHGHPGSS----SGGRQG 2475

Query: 797  NAYS-----GGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPN---AYSGGRDSSSNS 848
            + Y       GH S S +      GR + + GHS   ++   + N   +  G R S S  
Sbjct: 2476 SHYEQLVDRSGH-SGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRH 2534

Query: 849  YDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYG 908
            ++ S R    GH +  +G+S    +      + S D  ++ +S   + +S S  R+ H  
Sbjct: 2535 HEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHH-- 2592

Query: 909  RGGCYEEYQ--GRSPNAY-----GGGRGLNSSNNSHGRSHRYGGGGR----YEEYRGPSP 957
             G   E+ +   R P ++     G G   +SS  S  R  +   GG+    +E+ R  + 
Sbjct: 2593 -GSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAG 2651

Query: 958  DAHSGGRDSSIKSYGLSDRYGGGGH--------------YEEYQGSLPDAYSGDHD-RSS 1002
            + H      S      S R+ G GH              Y   Q S  + +S D D +S 
Sbjct: 2652 ERHGSHHQQSAD----SSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSV 2707

Query: 1003 NSYGRSDRYSRGRDRVGRPDRGLPLPMETGS-----PPLHDSYSRSGCRVPRGGGRQGGR 1057
            +++G++  + +      R   G      +GS          S S  G   P   GRQG R
Sbjct: 2708 SAHGQAGSHQQSHQESARGRSG-ETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSR 2766

Query: 1058 FERGEGRSRY 1067
             E+ +  SR+
Sbjct: 2767 HEQAQDSSRH 2776



 Score =  143 bits (360), Expect = 1e-33
 Identities = 250/1060 (23%), Positives = 380/1060 (35%), Gaps = 164/1060 (15%)

Query: 91   SSRWVPPTPGSGSRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKR 150
            SSR      G  S  R S     G S  Q   SQG  +D   ++G      + +   + R
Sbjct: 597  SSRHSQVGQGQSSGPRTSRNQ--GSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSR 654

Query: 151  GPPPRHWASPPHKRATPSSLAHSVG-CGMRGKAPTVSGQDGYSGLQPRRWAGPPH--KRA 207
                RH  S    RA     A S    G R    + SGQ   S  Q R  AG  H  +  
Sbjct: 655  DGS-RHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQ 713

Query: 208  VPRSSLARIGGSGMPGKAPAVW--GQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYG 265
            +  +  +R  G+G    + AV   G  G SG +  +                       G
Sbjct: 714  LQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDS---------------------EG 752

Query: 266  HSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKG--------------SYREPLKSYGGPC 311
            HS   D + + G G Q G+  + H+ +     G              ++++   S+G   
Sbjct: 753  HSEDSDTQSVSGHG-QAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSHG--- 808

Query: 312  GAAPVWGTPPSYG--GGCRYEEYQGNS---------------PDACSEGRS-SEALPVVL 353
                 W T PS G   G  +E+ + NS               P +   GR  S     V 
Sbjct: 809  -----W-TGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVD 862

Query: 354  PDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQ 413
               +S  H     S GRS +S G S S R        E + R    HSG R+  ++S+  
Sbjct: 863  RSGHSGSHHSHTTSQGRSDASRGQSGS-RSASRTTRNEEQSRDGSRHSGSRHHEASSHAD 921

Query: 414  SHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEE 473
               +   G+ +    R+   +    S D+ S G S+D       S  WS     G     
Sbjct: 922  ISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSED-------SERWS-----GSASRN 969

Query: 474  YQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSL---DANSGGRSPDTH 530
            ++G + + +  G         H  S   DR G G   + +R       + +SGG++  +H
Sbjct: 970  HRGSAQEQSRHGSR-------HPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSH 1022

Query: 531  SGGHSSSSNSYGQSH-------RYGGEGRYE----YRGRSHDAHSGGCSADAYSGGHDSS 579
                SS    +G  H       R+ G  R +     R   H   SG  ++D+     +S 
Sbjct: 1023 EQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESD 1082

Query: 580  SQS-NRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSL 638
            +QS + +G  G +++    S    SGGRS  + S  +  S+        GR     GR  
Sbjct: 1083 TQSVSGHGQDGPHQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQ 1142

Query: 639  DAN-SGGRSPDAYSGGHDSSGQSNCYGG---GGRYEEYRGRLLDAN-----------SGG 683
             ++    R    +S   +       + G   GGR   +  + +D +           S G
Sbjct: 1143 GSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQG 1202

Query: 684  RSPDAY--SGGHDSSSQSNR---YGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQS 738
            RS  ++  SG   +S Q+ +    G G R+   R H   + +         +   S S++
Sbjct: 1203 RSDASHGQSGSRSASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRT 1262

Query: 739  DHYGGGGRSLDANS------SGRLPDAYSGGHDSSSRSHRYGGG---GRYEEYR---GRS 786
              + G   S D++S      S RL  + S  H  SSR     G    G ++E R   G S
Sbjct: 1263 SRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHS 1322

Query: 787  LDANSGGRSPNAYSGGHNSS-SRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSS 845
             D++    + +  S  H  + S ++  R          H   A+S  HS     G R +S
Sbjct: 1323 ADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSG---IGHRQAS 1379

Query: 846  SNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSD 905
            S   D  HR   G       G S D+ ++  S    +G H        R     S GRS 
Sbjct: 1380 SAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSR 1439

Query: 906  HYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGG---GGRYEEYRGPSPDAHSG 962
             +        YQ  S            S ++HG++    G   G R+E+ R  S  + S 
Sbjct: 1440 SF-------LYQVSSH---------EQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQ 1483

Query: 963  GRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPD 1022
                +I+ +  S R G  G Y E Q      +SG H   +   GRSD  S G+       
Sbjct: 1484 DGQDTIRGHPGSSRGGRQGSYHE-QSVDRSGHSGYHHSHTTPQGRSDA-SHGQSGPRSAS 1541

Query: 1023 RGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGE 1062
            R      ++G    H S SR      R G  +  +  +GE
Sbjct: 1542 RQTRNEEQSGDGSRH-SGSRHHEPSTRAGSSRHSQVGQGE 1580



 Score =  142 bits (358), Expect = 2e-33
 Identities = 241/1000 (24%), Positives = 369/1000 (36%), Gaps = 172/1000 (17%)

Query: 104  RSRFSHRTRGGGSS-PQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPH 162
            +S  S R+R  GSS  Q   S+G  +D   ++G      + +   + R    RH  S   
Sbjct: 2877 QSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGS-RHPRSHQE 2935

Query: 163  KRATPSSLAHSVG-CGMRGKAPTVSGQDGYSGLQPRRWAGPPH----KRAVPRSSLARIG 217
             RA     A S    G R    +  GQ   S  Q R  AG  H    +++   S  + IG
Sbjct: 2936 DRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIG 2995

Query: 218  GSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRG 277
              G    A    G  GYSG +  +                       GHS   D + +  
Sbjct: 2996 -HGQASSAVRDSGHRGYSGSQASDN---------------------EGHSEDSDTQSVSA 3033

Query: 278  DG--------NQNGYRGRDHEYTDHPSKGSYR----EPLKSYGGPCGAAPVWGTPPSYGG 325
             G        +Q   RGR  E + H     Y+    E  +S  G       W  P + G 
Sbjct: 3034 HGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHG-------WTGPSTRGR 3086

Query: 326  -GCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYG 384
             G R+E+ Q +S  + S+              Y +D            +  G+  S R G
Sbjct: 3087 QGSRHEQAQDSSRHSASQ--------------YGQD------------TIRGHPGSSRGG 3120

Query: 385  EEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGE-GRYEEYRGRSHEARSGGRSTDAH 443
             +G + E+   S   HSG  +S + S G+S    G+ G     R   +E +SG  S  + 
Sbjct: 3121 RQGYHHEHSVDS-SGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSV 3179

Query: 444  SRGRSDDAYSGGHDSSSWSDCCGG---GGRYEEYQGRSL--DANSGGCSP--EAYSGGHD 496
            SR      ++   D S  S    G   G R    QG S+  D++S G S   E +SG   
Sbjct: 3180 SRHHEASTHA---DISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSAS 3236

Query: 497  NS-----SWSDRYGVG---GHYEENRGHSLDAN----SGGRSPDTHSGGHSSSSNSYGQS 544
             +         R+G      H+E+  GH   A+    SG R  +T SGG ++SS+   +S
Sbjct: 3237 RNHRGSVQEQSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARS 3296

Query: 545  ---HRYG-----------------GEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQS-N 583
                R+G                 G+     R   H   SG  ++D+     +S +QS +
Sbjct: 3297 SPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVS 3356

Query: 584  RYGGGGCYEEYRGRSLDANSGGRSPNAYS-----GGHDSSSWSH---RYGGGGRYEEYRG 635
             +G  G +++    S    SGGRS  + S       H+ S  +H   R   G R   +  
Sbjct: 3357 GHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHE 3416

Query: 636  RSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDS 695
            ++ D++    S +         G S     G  YE+   R    +SG       S G   
Sbjct: 3417 QARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDR--SGHSGSHHSHTTSQGRSD 3474

Query: 696  SSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDH----YGGGGRSLDAN 751
            +S+    G  G     R    D  SG  S  ++S  H++S+Q+D       G G+S    
Sbjct: 3475 ASR----GQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPR 3530

Query: 752  SSGRLPDAYSGGHDS---SSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYS---GGHNS 805
            +S     + S   DS   S  S R+ G             +  G R P ++     GH  
Sbjct: 3531 TSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGH 3590

Query: 806  SSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYR 865
            S+ +          ++  H  + +SGG + +++   R S+   +   H+         + 
Sbjct: 3591 SAESS--------RQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADS--SRHS 3640

Query: 866  GRSHDTHSRGRSPDAHSGDHYTEAY-SRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAY 924
            G  H   S       H G   ++A  S G    S++   S H G+ G +++    S    
Sbjct: 3641 GIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAH-GQAGPHQQSHQESTRGR 3699

Query: 925  GGGRGLNS------------SNNSHGRSHRYGGG---GRYEEYRGPSPDAHSGGRDSSIK 969
              GR   S            S ++HGR+    GG    R+E+ R  S  + S     +I+
Sbjct: 3700 SAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIR 3759

Query: 970  SYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSD 1009
             +  S R G  G Y E Q      +SG H   + S GRSD
Sbjct: 3760 GHPGSRRGGRQGSYHE-QSVDRSGHSGSHHSHTTSQGRSD 3798



 Score =  140 bits (352), Expect = 8e-33
 Identities = 243/984 (24%), Positives = 352/984 (35%), Gaps = 150/984 (15%)

Query: 114  GGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHS 173
            G S  Q   SQG  +D   ++G      + +   + R    RH  S    RA     A S
Sbjct: 2564 GSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGS-RHPRSHQEDRAGHGHSADS 2622

Query: 174  VG-CGMRGKAPTVSGQDGYSGLQPRRWAGPPH----KRAVPRSSLARIGGSGMPGKAPAV 228
                G R    +  GQ   S  Q R  AG  H    +++   S  + IG  G    A   
Sbjct: 2623 SRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIG-HGQASSAVRD 2681

Query: 229  WGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDG--------N 280
             G  GYSG +  +                       GHS   D + +   G        +
Sbjct: 2682 SGHRGYSGSQASDN---------------------EGHSEDSDTQSVSAHGQAGSHQQSH 2720

Query: 281  QNGYRGRDHEYTDHPSKGSYR----EPLKSYGGPCGAAPVWGTPPSYGG-GCRYEEYQGN 335
            Q   RGR  E + H     Y+    E  +S  G       W  P + G  G R+E+ Q +
Sbjct: 2721 QESARGRSGETSGHSGSFLYQVSTHEQSESSHG-------WTGPSTRGRQGSRHEQAQDS 2773

Query: 336  SPDACSEG-----RSSEALPVVLPDAYSRDHS--PKAYSGGRSSSSNGYSRSDRY-GEEG 387
            S  + S+      R            Y  +HS     +SG   S +    RSD   G+ G
Sbjct: 2774 SRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSG 2833

Query: 388  CYEEYRGRSPDAHSG--GRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSR 445
                 R    +  SG   R+S S  +  S H       +  +G+S  +R   R   + S+
Sbjct: 2834 SRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQ 2893

Query: 446  GRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGG--HDNSSWSDR 503
                + +S   DS  WS               S   N  G + E    G  H  S   DR
Sbjct: 2894 DSDSEGHS--EDSERWSG--------------SASRNHHGSAQEQLRDGSRHPRSHQEDR 2937

Query: 504  YGVGGHYEENRGHSLDAN--SGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHD 561
             G         GHS D++  SG R   T SGG ++SS+   +S      G +  +     
Sbjct: 2938 AG--------HGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSS 2989

Query: 562  AHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWS 621
             HSG     A S   DS    +R   G    +  G S D+++   S +  +G H     S
Sbjct: 2990 RHSGIGHGQASSAVRDS---GHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQ---S 3043

Query: 622  HRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANS 681
            H+    GR  E  G S        + +     H  +G S     G R+E+ +      +S
Sbjct: 3044 HQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDS--SRHS 3101

Query: 682  GGRSPDAYSGGHDSSSQSNRYG--------GGGRYEEYRGHSLD--------ANSGGRSP 725
              +       GH  SS+  R G          G    +  H+            SG RS 
Sbjct: 3102 ASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSA 3161

Query: 726  DTYSRGHDSSSQSDHYGGGGRSLDANSS---GRLPDAYSGGHDSSSRSHRYGGG-GRYEE 781
               +R  + S  S  +    R  +A++     R   A  G  + S RS R G    +  +
Sbjct: 3162 SRTTRNEEQSGDSSRH-SVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSD 3220

Query: 782  YRGRSLDAN--SGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDAN----SGGHSP 835
              G S D+   SG  S N + G     SR+        +E+  GH   A+    SG    
Sbjct: 3221 SEGHSEDSERWSGSASRN-HRGSVQEQSRHGSRHPRSHHEDRAGHGHSADRSRQSGTRHA 3279

Query: 836  NAYSGGRDSSSNSYDRSH--RYGGGGHYEEYRGRSHDTHSRGRSPDA-----HSGDHYTE 888
               SGG+ +SS+   RS      G  H +      H    RG++  A     H G   ++
Sbjct: 3280 ETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQ 3339

Query: 889  AY-SRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNS------------SNN 935
            A  S G    S++   S H G+ G +++    S     GGR   S            S +
Sbjct: 3340 ASDSEGHSEESDTQSVSGH-GQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSES 3398

Query: 936  SHGRSHRYGG---GGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYG-GGGHYEEYQGSLP 991
            +HGR+    G   G  +E+ R  S  + S     +I+ +  S R G  G HYE  Q    
Sbjct: 3399 AHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYE--QSVDR 3456

Query: 992  DAYSGDHDRSSNSYGRSDRYSRGR 1015
              +SG H   + S GRSD  SRG+
Sbjct: 3457 SGHSGSHHSHTTSQGRSDA-SRGQ 3479



 Score =  137 bits (346), Expect = 4e-32
 Identities = 240/1000 (24%), Positives = 360/1000 (36%), Gaps = 151/1000 (15%)

Query: 110  RTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSS 169
            R R G    Q   S+G  +D   ++G      + +   + R    RH  S    RA+   
Sbjct: 290  RKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGS-RHPRSHDEDRASHGH 348

Query: 170  LAHSVG-CGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRS---SLARIGGSGMPGKA 225
             A S    G R    +  GQ   S  Q R   G  H     +S   S     G G    A
Sbjct: 349  SADSSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQASSA 408

Query: 226  PAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDG------ 279
             +  G  G SG +  +                       GHS   D + + G G      
Sbjct: 409  VSDRGHRGSSGSQASDS---------------------EGHSENSDTQSVSGHGKAGLRQ 447

Query: 280  --NQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSP 337
              +Q   RGR  E +       Y+  + ++  P  A    GT      G  +E+ + +S 
Sbjct: 448  QSHQESTRGRSGERSGRSGSSLYQ--VSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSSR 505

Query: 338  DACSE---------------GRS-SEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSD 381
             + S+               GR  S     V    +S  H     S GRS +S+G S S 
Sbjct: 506  HSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDASHGQSGSR 565

Query: 382  RYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTD 441
                +   EE  G     HSG R+  ++S   S  +   G+ +    R+   +    S D
Sbjct: 566  SASRQTRNEEQSG-DGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQD 624

Query: 442  AHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWS 501
            + S+G S+       DS  WS        +   Q +S D +    S      GH +S+ S
Sbjct: 625  SDSQGHSE-------DSERWSG-SASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADS 676

Query: 502  DRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSH--------RYGGEGRY 553
             R   G  + +N       +S G++  +H    SS+   +G  H        R+ G G  
Sbjct: 677  SRKS-GTRHTQN-------SSSGQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHG 728

Query: 554  E----YRGRSHDAHSGGCSADAYSGGHDSSSQS-NRYGGGGCYEEYRGRSLDANSGGRSP 608
            +     R   H   SG  + D+     DS +QS + +G  G +++    S    SG RS 
Sbjct: 729  QASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERSR 788

Query: 609  NAYS-----GGHDSSSWSHRYGG---GGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQS 660
             + S       H  S  SH + G   G R   +  ++ D +    S D         GQ 
Sbjct: 789  RSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQD---------GQD 839

Query: 661  NCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANS 720
               G  G     RGR    +        +SG H S + S      GR +  RG      S
Sbjct: 840  TIRGHPG--SSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQ-----GRSDASRG-----QS 887

Query: 721  GGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSS---GRLPDAYSGGHDSSSRSHRYGGG- 776
            G RS    +R  + S     +  G R  +A+S     R   A  G  + S  S R G   
Sbjct: 888  GSRSASRTTRNEEQSRDGSRH-SGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSV 946

Query: 777  GRYEEYRGRSLDAN--SGGRSPNAYSGGHNSSSRNDPCRGGGRYEE--NRGHSLDANSGG 832
             +  +  G S D+   SG  S N + G     SR+        +E+    GHS D++   
Sbjct: 947  SQDSDSEGHSEDSERWSGSASRN-HRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQS 1005

Query: 833  HSPNA--YSGGRDSSSNSYDRS---HRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYT 887
             +P+A   SGG+ +SS+   RS    R+G          R      R  S       H+ 
Sbjct: 1006 GTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWG 1065

Query: 888  EAYSRGRDSFSNSYGRSDH----YGRGGCYEEYQGRSPNAYGGGRGLNS----------- 932
             + S+  DS  +S          +G+ G +++    S   + GGR   S           
Sbjct: 1066 SSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDWSGGRSGRSGSFIYQVSTHE 1125

Query: 933  -SNNSHGRSHRYGG---GGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQG 988
             S ++HGR+    G   G  +E+ R  S  + S     +I+++  S R G  G + E Q 
Sbjct: 1126 QSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHE-QS 1184

Query: 989  SLPDAYSGDHDRSSNSYGRSDRY-----SRGRDRVGRPDR 1023
                 +SG H   + S GRSD       SR   R  R D+
Sbjct: 1185 VDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDK 1224



 Score =  137 bits (344), Expect = 7e-32
 Identities = 197/804 (24%), Positives = 303/804 (37%), Gaps = 98/804 (12%)

Query: 326  GCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGE 385
            G +    +G+S D+ ++  S+         A     S K  + G+S  S+G SRS  Y  
Sbjct: 1392 GSQVTNSEGHSEDSDTQSVSAHG------QAGPHQQSHKESARGQSGESSGRSRSFLYQV 1445

Query: 386  EGCYEEYRGRSPDAHS-GGRNSSSNSYGQ--SHHYGGEGRYEEYRGRSHEARSGGRSTDA 442
                +        A S GGR  S +   +  S H   +   +  RG    +R GGR    
Sbjct: 1446 SSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSR-GGRQGSY 1504

Query: 443  HSRGRSDDAYSGGHDSSSW----SDCCGG--GGRYEEYQGRSLDANSGGC--------SP 488
            H +      +SG H S +     SD   G  G R    Q R+ + +  G          P
Sbjct: 1505 HEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEP 1564

Query: 489  EAYSGGHDNSSWSDRYGVGGHYEENRGHSL--DANSGGRSPDTHSGGHSSSSNSYGQSHR 546
               +G   +S        G      +G S+  D +S G S D+     S+S N YG +  
Sbjct: 1565 STRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSARE 1624

Query: 547  YGGEGRYEYRGRSHDAHSGGCSADAY-----------SGGHDSSSQSNRYGG-----GGC 590
                G    R    D  S G SA++            SGG  +SSQ           G  
Sbjct: 1625 QSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSR 1684

Query: 591  YEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAY 650
            +++    S D+ +G R  ++  G  DS +   R   G +  +  G S ++++   S    
Sbjct: 1685 HQQSADSSTDSGTGRRQDSSVVG--DSGN---RGSSGSQASDSEGHSEESDTQSVSAHGQ 1739

Query: 651  SGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEE 710
            +G H  S Q +  G  G      G  L   S     ++  G    S+     GG  R   
Sbjct: 1740 AGPHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPST-----GGRQRSRH 1794

Query: 711  YRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRS 770
             +      +S  +      RGH  SS+    G        +SSG     +SG H S + S
Sbjct: 1795 EQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQ-SVDSSG-----HSGSHHSHTTS 1848

Query: 771  HRY-----GGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR---------GGG 816
                    G  G     R    +  SG  S ++ S  H +SSR D  R          G 
Sbjct: 1849 QERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGP 1908

Query: 817  RYEENRGHSL--DANSGGHSPNAY----SGGRDSSSNSYDRSHRYGG---GGHYEEYRGR 867
            R   N+G S+  D++S GHS ++     S  R+   +++++S R G    G H+E+  G 
Sbjct: 1909 RTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQS-RDGSRHPGSHHEDRAGH 1967

Query: 868  SHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGG 927
             H   S        SG  +TE+ SRG+ + S+   RS    R G + + Q    + + G 
Sbjct: 1968 GHSADS-----SRQSGTRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRHSGI 2022

Query: 928  RGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHS------GGRDSSIKSYGLSDRYGGGG 981
                +S+      HR   G +  +  G S D+ +      G      +S+  S R G  G
Sbjct: 2023 GHGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESAR-GQSG 2081

Query: 982  HYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYS 1041
                  GS     S  H++S +++G+S   + GR +    D+       + S    D+  
Sbjct: 2082 ESSGRSGSFLYQVS-THEQSESTHGQSAPSTGGR-QGSHYDQAQDSSRHSASQEGQDTI- 2138

Query: 1042 RSGCRVPRGGGRQGGRFERGEGRS 1065
              G   P  GGRQG   E+   RS
Sbjct: 2139 -RGHPGPSRGGRQGSHQEQSVDRS 2161



 Score =  130 bits (327), Expect = 7e-30
 Identities = 214/889 (24%), Positives = 330/889 (37%), Gaps = 125/889 (14%)

Query: 265  GHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKG--SYREPLKSYGGPCGAAPVWGTP-- 320
            GHS   D     G  ++N +RG   E + H S+   S+ E    +G    ++   GTP  
Sbjct: 954  GHSE--DSERWSGSASRN-HRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHA 1010

Query: 321  --PSYGGGCRYEEYQGNSPDACSEGRSSEA--------LPVVLPDAYSRDHSPKAYSGGR 370
               S G      E   +SP      R  ++        +P     +  RD      SG +
Sbjct: 1011 ETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSGSQ 1070

Query: 371  SSSSNGYSRSDR------YGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYE 424
            +S S G+S          +G++G +++    S    SGGR+  S S+   +      + E
Sbjct: 1071 ASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDWSGGRSGRSGSF--IYQVSTHEQSE 1128

Query: 425  EYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGG---GGRYEEYQGRSLDA 481
               GR+  + +G R    H + R    +S   +         G   GGR   +  +S+D 
Sbjct: 1129 SAHGRTRTS-TGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGSHHEQSVDR 1187

Query: 482  NSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSY 541
            +    S  +++     S  S  +G  G    +R    D  SG  S   HSG     + S+
Sbjct: 1188 SGHSGSHHSHTTSQGRSDAS--HGQSGSRSASRQTRKDKQSGDGS--RHSGSRHHEAASW 1243

Query: 542  GQSHRYGGEGRYEYRGRSHDAHSGGC-SADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLD 600
              S R+   G+ +  G     H G   S D+ S  H  S  S R  G      +      
Sbjct: 1244 ADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERH--SDDSERLSGSASRNHHGSSREQ 1301

Query: 601  ANSGGRSPNAYS---GGHDSSSWSHRYGGGGRYEEY-RGRSLDANSGGRSP--DAYSGGH 654
            +  G R P  +      H  S+ S R  G    E    G+++ ++   RS   + +   H
Sbjct: 1302 SRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRH 1361

Query: 655  DSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAY--SGGH--DSSSQS-NRYGGGGRYE 709
              S  S+ + G G + +    + D+   G S      S GH  DS +QS + +G  G ++
Sbjct: 1362 QQSADSSRHSGIG-HRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQ 1420

Query: 710  EYRGHSLDANSG---GRSPD-TYSRGHDSSSQSDH------YGG--GGRSLDANSSGRLP 757
            +    S    SG   GRS    Y       S+S H       GG  G R   A +S R  
Sbjct: 1421 QSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHS 1480

Query: 758  DAYSG-----GHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPC 812
             +  G     GH  SSR      GGR   Y  +S+D +        +SG H+S +     
Sbjct: 1481 ASQDGQDTIRGHPGSSR------GGRQGSYHEQSVDRSG-------HSGYHHSHTTPQ-- 1525

Query: 813  RGGGRYEENRGHSLDANSGGHSPN---AYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSH 869
               GR + + G S   ++   + N   +  G R S S  ++ S R G   H +  +G S 
Sbjct: 1526 ---GRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESA 1582

Query: 870  DTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAY----- 924
             + +  R   + S D  +E +S   +  S S  R+ HYG       +  R+P ++     
Sbjct: 1583 GSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRN-HYGSAREQSRHGSRNPRSHQEDRA 1641

Query: 925  GGGRGLNSSNNSHGRSHRYGGGG-------------------RYEEYRGPSPDAHSGGRD 965
              G    SS  S  R      GG                   R+++    S D+ +G R 
Sbjct: 1642 SHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQ 1701

Query: 966  SSIKSYGLSDRYGGG-------GHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRV 1018
             S       +R   G       GH EE       A+ G       S+  S R   G +R 
Sbjct: 1702 DSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAH-GQAGPHQQSHQESTRGQSG-ERS 1759

Query: 1019 GRPDRGLPLPMETGSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
            GR   G  L   +       ++ R+G   P  GGRQ  R E+    SR+
Sbjct: 1760 GRS--GSFLYQVSTHEQSESAHGRTG---PSTGGRQRSRHEQARDSSRH 1803



 Score =  129 bits (324), Expect = 1e-29
 Identities = 236/983 (24%), Positives = 334/983 (33%), Gaps = 156/983 (15%)

Query: 149  KRGPPPRHWASPPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAV 208
            +  P  RH +   H+++  SS     G          SG  G SG Q     G  H    
Sbjct: 1674 RSSPGERHGSR--HQQSADSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEG--HSEES 1729

Query: 209  PRSSLARIGGSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSS 268
               S++  G +G P +        G SG R           G F+  +  + +    H  
Sbjct: 1730 DTQSVSAHGQAG-PHQQSHQESTRGQSGERSGRS-------GSFLYQVSTHEQSESAHGR 1781

Query: 269  VPDYRPLRGDGNQNGYRGRD-HEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGC 327
                      G   G R R  HE     S+ S  +         G   + G P S  GG 
Sbjct: 1782 T---------GPSTGGRQRSRHEQARDSSRHSASQE--------GQDTIRGHPGSSRGGR 1824

Query: 328  RYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEG 387
            +   Y+ +                V    +S  H     S  RS  S G S S     + 
Sbjct: 1825 QGSHYEQS----------------VDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQT 1868

Query: 388  CYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGR 447
              E+  G     HSG R+  ++S   S  +   G+ +    R+   +    S D+ S+G 
Sbjct: 1869 RNEKQSGDG-SRHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGH 1927

Query: 448  SDDA--YSGG----HDSSSWSDCCGG----GGRYEEYQGRSLDANS----GGCSPEAYSG 493
            S+D+  +SG     H  S+W     G    G  +E+  G    A+S    G    E+ S 
Sbjct: 1928 SEDSERWSGSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESSSR 1987

Query: 494  GHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSG-GHSSSSNSYGQS-HR-YGGE 550
            G   SS        G    +  H L +    R    HSG GH  +S++   S HR Y G 
Sbjct: 1988 GQAASSHEQARSSAGERHGSH-HQLQSADSSR----HSGIGHGQASSAVRDSGHRGYSGS 2042

Query: 551  GRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLD---------- 600
               +  G S D+ +   SA   +G H  S + +  G  G   E  GRS            
Sbjct: 2043 QASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSG---ESSGRSGSFLYQVSTHEQ 2099

Query: 601  ---------ANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYS 651
                      ++GGR  + Y    DSS  S    G      + G S     G     +  
Sbjct: 2100 SESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVD 2159

Query: 652  -GGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYE- 709
              GH  S  S+     GR +  RG+     SG RS    +   + S   +R+ G   +E 
Sbjct: 2160 RSGHSGSHHSHT-TSQGRSDASRGQ-----SGSRSASRKTYDKEQSGDGSRHSGSHHHEA 2213

Query: 710  ----EYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHD 765
                +   HSL        P T SR   SS   D    G        SG     + G   
Sbjct: 2214 SSWADSSRHSLVGQGQSSGPRT-SRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQ 2272

Query: 766  SSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAY---SGGHNSSSRNDPCRGGGRYEENR 822
              SR         +E+  G    A S  +S   +   S G  ++S ++  R         
Sbjct: 2273 EQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGS 2332

Query: 823  GHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHS 882
             H   A+S  HS     G   +SS   D  HR   G    +  G S D+ ++  S    +
Sbjct: 2333 HHQQSADSSRHSG---IGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQA 2389

Query: 883  GDHYT--EAYSRGRDSFSNSYGRSDHYGRGGCY----------EEYQGRSPNAYGGGRGL 930
            G H    +  +RGR     S GRS   GR G +          E   GR+  + GG +G 
Sbjct: 2390 GPHQQSHQESTRGR-----SAGRS---GRSGSFLYQVSTHEQSESAHGRTGTSTGGRQG- 2440

Query: 931  NSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSL 990
             S +     S R+      ++     P + SGGR               G HYE+     
Sbjct: 2441 -SHHKQARDSSRHSTSQEGQDTIHGHPGSSSGGRQ--------------GSHYEQLVDR- 2484

Query: 991  PDAYSGDHDRSSNSYGRSDRY-----SRGRDRVGRPDRGLPLPMETGSPPLHDSYSR--- 1042
               +SG H   + S GRSD       SR   R  R D              H++ SR   
Sbjct: 2485 -SGHSGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADS 2543

Query: 1043 SGCRVPRGGGRQGGRFERGEGRS 1065
            SG      G  +G R  R  G S
Sbjct: 2544 SGHSQVGQGQSEGPRTSRNWGSS 2566



 Score =  127 bits (318), Expect = 7e-29
 Identities = 214/959 (22%), Positives = 329/959 (34%), Gaps = 137/959 (14%)

Query: 162  HKRATPSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGM 221
            H+++  SS    +G G    A   SG  GYSG Q     G          S     GS  
Sbjct: 2982 HQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQ 3041

Query: 222  PGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHS-SVPDYRPLRGDGN 280
                 +  G+ G +              G F+  +  + +    H  + P  R  +G  +
Sbjct: 3042 QSHQESARGRSGETSGH----------SGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRH 3091

Query: 281  QNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEY--QGNSPD 338
            +       H  + +        P  S GG  G         S   G  +     QG S  
Sbjct: 3092 EQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDA 3151

Query: 339  ACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSS---------------SNGYSRSDRY 383
            +  +  S  A      +  S D S  + S    +S               S G  RS R 
Sbjct: 3152 SRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQ 3211

Query: 384  GEEGCYE-EYRGRSPDAHSGGRNSSSNSYG----QSHHYGGEGR--YEEYRGRSH----- 431
            G     + +  G S D+     ++S N  G    QS H     R  +E+  G  H     
Sbjct: 3212 GSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRSHHEDRAGHGHSADRS 3271

Query: 432  --------EARSGGRSTDAHSRGRSD--DAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDA 481
                    E  SGG++  +H + RS   + +   H  S+ S    G  R +       D+
Sbjct: 3272 RQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQA-SSAVRDS 3330

Query: 482  NSGGCSPEAYSGGHDNSSWSDRYGVGGH-----YEENRGHSLDANSGGRSPDTHS----- 531
               G S    S    +S  SD   V GH     ++++   S    SGGRS  + S     
Sbjct: 3331 RHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQV 3390

Query: 532  GGHSSSSNSYGQSHRYGG--EGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGG 589
              H  S +++G++    G  +G +  + R    HS          GH  SS+  R G   
Sbjct: 3391 STHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSH- 3449

Query: 590  CYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDA 649
             YE+   RS   +SG    +  S G   +S     G  G     R    D  SG  S  +
Sbjct: 3450 -YEQSVDRS--GHSGSHHSHTTSQGRSDAS----RGQSGSRSASRQTRNDEQSGDGSRHS 3502

Query: 650  YSGGHDSSGQ--SNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGR 707
            +S  H++S Q  S+ +   G+ +    R         S D+ S GH  S  S R+ G   
Sbjct: 3503 WSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGH--SEDSERWSGSAS 3560

Query: 708  YEEYRGHSLDANSGGRSPDTYSR---GHDSSSQSDHYGG--------GGRSLDANSSGRL 756
                      +  G R P ++     GH  S++S    G        GG++  ++   R 
Sbjct: 3561 RNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARS 3620

Query: 757  P---------------DAYSG-GHDSSSRS-----HRYGGGGRYEEYRGRSLDANSGGRS 795
                              +SG GH  +S +     HR   G +  +  G S D+++   S
Sbjct: 3621 SAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVS 3680

Query: 796  PNAYSGGHNSSSRNDPC-RGGGR---------------YEENRGHSLDANSGGHSPNAYS 839
             +  +G H  S +     R  GR                 E+       ++GG   + + 
Sbjct: 3681 AHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHE 3740

Query: 840  GGRDSSSNSYDRSHRYGGGGHYEEYRG-RSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFS 898
              RDSS +S  +  +    GH    RG R    H +      HSG H++   S+GR   S
Sbjct: 3741 QARDSSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDAS 3800

Query: 899  NSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGG-----GGRYEEYR 953
            +    S    R    EE  G   + + G R   +S  +    H   G     G R    +
Sbjct: 3801 HGQSGSRSASRETRNEEQSG-DGSRHSGSRHHEASTQADSSRHSQSGQGESAGSRRSRRQ 3859

Query: 954  GPS----PDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRS 1008
            G S     D+ +   DS  +S   S  + G    +   GS    + G   R + S+ +S
Sbjct: 3860 GSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGS---RHPGSSHRDTASHVQS 3915



 Score =  126 bits (316), Expect = 1e-28
 Identities = 173/754 (22%), Positives = 270/754 (35%), Gaps = 80/754 (10%)

Query: 358  SRDHS--PKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSH 415
            SRD S  P+++   R+S  +    S + G        RG++  +H   R+S    +G  H
Sbjct: 329  SRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGH 388

Query: 416  HYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQ 475
                +       GR  +A S            S  + S GH  +S +    G G+     
Sbjct: 389  QQSADSSRHSATGRG-QASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGK----- 442

Query: 476  GRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANS-GGRSPDTHSGGH 534
               L   S   S    SG     S S  Y V  H + +  H     S GGR    H    
Sbjct: 443  -AGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHEQAR 501

Query: 535  SSSSNSYGQ-----------SHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSN 583
             SS +S  Q           S R G +G +  +  +   HSG   +   S G   +S   
Sbjct: 502  DSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDAS--- 558

Query: 584  RYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSW--SHRYGGGGRYEEYRGRSLDAN 641
             +G  G     R    +  SG  + ++ S  H++SS   S R+   G+ +    R+    
Sbjct: 559  -HGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQ 617

Query: 642  SGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAY---SGGHDSSSQ 698
                S D+ S GH  S  S  + G      +      +  G R P ++     GH  S+ 
Sbjct: 618  GSSVSQDSDSQGH--SEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAD 675

Query: 699  SNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPD 758
            S+R  G         H+ +++SG  +    S     SS  + +G   +   A+SS     
Sbjct: 676  SSRKSG-------TRHTQNSSSGQAAS---SHEQARSSAGERHGSRHQLQSADSS----- 720

Query: 759  AYSG-GHDSSSRS-----HRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPC 812
             +SG GH  +S +     HR   G +  +  G S D+++   S +  +G H  S +    
Sbjct: 721  RHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESAR 780

Query: 813  RGGGRYEENRG---HSLDANSGGHSPNAYSG-------------GRDSSSNSYDRSHRYG 856
               G      G   + +  +    S + ++G              RD+S +S  +  +  
Sbjct: 781  DRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDT 840

Query: 857  GGGH-YEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEE 915
              GH     RGR    H +      HSG H++   S+GR   S     S    R    EE
Sbjct: 841  IRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEE 900

Query: 916  YQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSD 975
             Q R  + + G R   +S+++    H   G G+ E  R       S  +DS  + +    
Sbjct: 901  -QSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDS 959

Query: 976  RYGGGGHYEEYQGSLPD--AYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGS 1033
                G     ++GS  +   +   H RS +     DR   G         G P   ET S
Sbjct: 960  ERWSGSASRNHRGSAQEQSRHGSRHPRSHH----EDRAGHGHSADSSRQSGTP-HAETSS 1014

Query: 1034 PPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
                 S        P  G R G R ++    SR+
Sbjct: 1015 GGQAASSHEQARSSP--GERHGSRHQQSADSSRH 1046



 Score =  112 bits (280), Expect = 2e-24
 Identities = 155/684 (22%), Positives = 250/684 (36%), Gaps = 67/684 (9%)

Query: 359  RDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYG 418
            R  SP+   G R  SS+       Y      EEY     ++    +N + N+    +   
Sbjct: 140  RSKSPRETGGKRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKR 199

Query: 419  GEGRYEEYRGRS---HEARSGGRSTDAH-SRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY 474
               R EE        ++  + GR T      G     Y+   ++   +D      +  E 
Sbjct: 200  LSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYE- 258

Query: 475  QGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGH 534
            + RS D  S   S +     H+N+S                 S D +S G S D+     
Sbjct: 259  RSRSSDGKS---SSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSG 315

Query: 535  SSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSAD-AYSGGHDSSSQSNRYGGGGCYEE 593
            S+S N +G +     +G    R    D  S G SAD +   G   +  S+R      +E+
Sbjct: 316  SASRNHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQ 375

Query: 594  YRGRSLDANSGGRSPNAYSGGHDS----------SSWSHRYGGGGRYEEYRGRSLDANSG 643
             R    + +  G   +A S  H +          S   HR   G +  +  G S ++++ 
Sbjct: 376  ARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQ 435

Query: 644  GRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYG 703
              S    +G    S Q +  G  G      G  L   S    PD+  G   +S+   +  
Sbjct: 436  SVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQ-- 493

Query: 704  GGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGG 763
             G  +E+ R  S   +S  +      RGH  SS+      GGR    +        +SG 
Sbjct: 494  -GSHHEQARDSS--RHSASQEGQDTIRGHPGSSR------GGRQGSHHEQSVNRSGHSGS 544

Query: 764  HDSSSRSH-----RYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR----- 813
            H S + S       +G  G     R    +  SG  + ++ S  H +SS+ D  R     
Sbjct: 545  HHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQVG 604

Query: 814  ----GGGRYEENRGHSL--DANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGG------HY 861
                 G R   N+G S+  D++S GHS ++      +S N +  +      G      H+
Sbjct: 605  QGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSRDGSRHPRSHH 664

Query: 862  EEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSP 921
            E+  G  H   S  +     SG  +T+  S G+ + S+   RS    R G   + Q    
Sbjct: 665  EDRAGHGHSADSSRK-----SGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQLQSADS 719

Query: 922  NAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGG 981
            + + G     +S+      HR   G +  +  G S D+ +     S+  +G +     G 
Sbjct: 720  SRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDT----QSVSGHGQA-----GH 770

Query: 982  HYEEYQGSLPDAYSGDHDRSSNSY 1005
            H + +Q S  D  SG+  R S S+
Sbjct: 771  HQQSHQESARDR-SGERSRRSGSF 793



 Score =  106 bits (265), Expect = 1e-22
 Identities = 242/1091 (22%), Positives = 370/1091 (33%), Gaps = 191/1091 (17%)

Query: 103  SRSRFSHRTRGGGSSPQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPH 162
            +R R   R+   GSS  +  +  +PD   G  G               G    H     H
Sbjct: 454  TRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTG-----------TSTGGRQGSH-----H 497

Query: 163  KRATPSSLAHSVGCGMRGKAPTVSGQD---GYSGLQPRRWAGPPHKRAVPRS--SLARIG 217
            ++A  SS  HS          +  GQD   G+ G       G  H+++V RS  S +   
Sbjct: 498  EQARDSS-RHSA---------SQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHS 547

Query: 218  GSGMPGKAPAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPD--YRPL 275
             +   G++ A  GQ G      R      R+        R    R++  SS  D      
Sbjct: 548  HTTSQGRSDASHGQSG-----SRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQ 602

Query: 276  RGDGNQNGYRGRDHEYT----DHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEE 331
             G G  +G R   ++ +    D  S+G + E  + + G                G R+  
Sbjct: 603  VGQGQSSGPRTSRNQGSSVSQDSDSQG-HSEDSERWSGSASRNHHGSAQEQSRDGSRHP- 660

Query: 332  YQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEE 391
             + +  D    G S+++         S     +  S G+++SS+  +RS      G   +
Sbjct: 661  -RSHHEDRAGHGHSADS------SRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQ 713

Query: 392  YRGRSPDAHSG-GRNSSSNSYGQSHH-------------------------YGGEGRYEE 425
             +      HSG G   +S++   S H                         +G  G +++
Sbjct: 714  LQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQ 773

Query: 426  YRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGG---GGRYEEYQGRSLDAN 482
                S   RSG RS  + S       +     S  W+    G   G  +E  Q R    +
Sbjct: 774  SHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHE--QARDNSRH 831

Query: 483  SGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYG 542
            S     +    GH  SS   R   G H+E++   S   +SG     T S G S +S    
Sbjct: 832  SASQDGQDTIRGHPGSSRRGRQ--GSHHEQSVDRS--GHSGSHHSHTTSQGRSDASRGQS 887

Query: 543  QSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQS--NRYGGGGCYEEYRGRSLD 600
             S       R E + R    HSG       S  H++SS +  +R+   G  +    R+  
Sbjct: 888  GSRSASRTTRNEEQSRDGSRHSG-------SRHHEASSHADISRHSQAGQGQSEGSRTSR 940

Query: 601  ANSGGRSPNAYSGGH--DSSSWSHRYGGGGRYEEYRGRSLD-ANSGGRSPDAY---SGGH 654
                  S ++ S GH  DS  WS     G     +RG + + +  G R P ++     GH
Sbjct: 941  RQGSSVSQDSDSEGHSEDSERWS-----GSASRNHRGSAQEQSRHGSRHPRSHHEDRAGH 995

Query: 655  DSSGQSNCYGGGGRYE-EYRGRLLDANSGGRSP--DAYSGGHDSSSQSNRYGGGGRYE-- 709
              S  S+   G    E    G+   ++   RS   + +   H  S+ S+R+ G  R +  
Sbjct: 996  GHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRRQAS 1055

Query: 710  ---EYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDS 766
                  GH   + S     + +S   D+ S S H   G        S R    +SGG   
Sbjct: 1056 SAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESAR---DWSGGRSG 1112

Query: 767  SSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDP-------------CR 813
             S S  Y      +          S GR   ++      SSR+                R
Sbjct: 1113 RSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSR 1172

Query: 814  GGGRYEENRGHSLD--ANSGGHSPNAYSGGRDSSSNSYDRSH----------------RY 855
             GGR   +   S+D   +SG H  +  S GR  +S+    S                 R+
Sbjct: 1173 RGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQSGDGSRH 1232

Query: 856  GGGGHYEEYRGRSHDTHSR-------GRSPDAHSG-----DHYTEAYSRGRDSFSNSYGR 903
             G  H+E         HS+       G     H G     D  +E +S   +  S S  R
Sbjct: 1233 SGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASR 1292

Query: 904  SDHYGRGGCYEEYQGRSPNAY-----GGGRGLNSSNNS---HGRSHRYGGGGRYEEYRGP 955
             +H+G          R P  +       G   +SS  S   H  S  +G      E    
Sbjct: 1293 -NHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARS 1351

Query: 956  SPDAHSGGRDSSIKSYGLSDRYGGGGHYEE--------YQGSL------PDAYSGDHD-R 1000
            SP    G R         S R+ G GH +         ++GS        + +S D D +
Sbjct: 1352 SPGERHGSRHQQSAD---SSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQ 1408

Query: 1001 SSNSYGRSDRYSRGRDRVGRPDRGLPLPMETG---SPPLHD-SYSRSGCRVPRGGGRQGG 1056
            S +++G++  + +      R   G               H+ S S  G   P  GGRQG 
Sbjct: 1409 SVSAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPSTGGRQGS 1468

Query: 1057 RFERGEGRSRY 1067
            R E+    SR+
Sbjct: 1469 RHEQARNSSRH 1479



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 170/720 (23%), Positives = 241/720 (33%), Gaps = 130/720 (18%)

Query: 155  RHWASPPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLA 214
            RHW S      + S  + S G        +VSG  G +G         PH+++   S+  
Sbjct: 3331 RHWGS------SGSQASDSEGHSEESDTQSVSGH-GQAG---------PHQQSHQESARD 3374

Query: 215  RIGG-SGMPGK-APAVWGQDGYSGPRVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDY 272
            R GG SG  G     V   +       R      R  G      RD SR           
Sbjct: 3375 RSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTI 3434

Query: 273  RPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEY 332
            R   G       RGR         +GS+ E      G  G+     T        R    
Sbjct: 3435 RGHPGSSR----RGR---------QGSHYEQSVDRSGHSGSHHSHTTSQGRSDASRG--- 3478

Query: 333  QGNSPDACSEGRSSEALPVVLPDAYSRDH--SPKAYSGGRSSSSNGYSRSDRYGEE---- 386
            Q  S  A  + R+ E        ++S  H  S +A S   S S  G S   R        
Sbjct: 3479 QSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSS 3538

Query: 387  -GCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEG------RYEEYRGRSHEARSGGRS 439
                 + +G S D+     ++S N  G +     +G       +E+  G  H A S  +S
Sbjct: 3539 VSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQS 3598

Query: 440  TDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANS------GGCSPEAYSG 493
               H+   S    +  H+ +  S     G R+  +  +S D++       G  S      
Sbjct: 3599 GTHHAENSSGGQAASSHEQARSS----AGERHGSHHQQSADSSRHSGIGHGQASSAVRDS 3654

Query: 494  GHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRY 553
            GH  SS S      GH E++   S+ A+ G   P   S   S+   S G+S   G  G +
Sbjct: 3655 GHRGSSGSQASDSEGHSEDSDTQSVSAH-GQAGPHQQSHQESTRGRSAGRS---GRSGSF 3710

Query: 554  EYRGRSHD----AH------SGGCSADAYSGGHDSSSQSNRYGG------------GGCY 591
             Y+  +H+    AH      +GG     +    DSS  S    G            GG  
Sbjct: 3711 LYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQ 3770

Query: 592  EEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGG------RYEEYRGRSLDANSGGR 645
              Y  +S+D +    S ++++     S  SH   G        R EE  G     +SG R
Sbjct: 3771 GSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDG-SRHSGSR 3829

Query: 646  ----SPDAYSGGHDSSGQSNCYG-------GGGRYEEYRGRLLDANSGGRSPDAYSGGHD 694
                S  A S  H  SGQ    G       G    ++        +S  RS  A    H 
Sbjct: 3830 HHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHG 3889

Query: 695  SSSQSNRYGG---GGRYEEYRGH--------------------SLDANSGGRSPDTYSRG 731
            SS + +R G    G  + +   H                    SL  +S   S    SRG
Sbjct: 3890 SSREQSRDGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYHS-GIQSRG 3948

Query: 732  HDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGG-RYEEYRGRSLDAN 790
               SS S HY   G       SG +    S G    S  + YG  G R+ ++   S ++N
Sbjct: 3949 SPHSSSSYHYQSEGTERQKGQSGLVWRHGSYG----SADYDYGESGFRHSQHGSVSYNSN 4004



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 133/605 (21%), Positives = 196/605 (32%), Gaps = 84/605 (13%)

Query: 498  SSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRY---- 553
            S+  +   + GH  ++R HS          + +       S+   +++R G +GR     
Sbjct: 88   STRKENLPISGH--KHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPR 145

Query: 554  EYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLD-ANSGGRSPNAYS 612
            E  G+ H++ S       YS  H        +      E+ +  +    ++  R      
Sbjct: 146  ETGGKRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLE 205

Query: 613  GGHDSSSWSHRYGGGGR-------------YEEYRGRSLDANSGGRSPDA-YSGGHDSSG 658
               D+    + Y   GR             Y   +  + D        +  Y     S G
Sbjct: 206  EKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDG 265

Query: 659  QSNCYGGGGRYEE------YRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYR 712
            +S+      R+E          R         S D  S GH  S  S R+ G      + 
Sbjct: 266  KSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGH--SEDSERHSGSASRNHHG 323

Query: 713  GHSLDANSGGRSP-----DTYSRGH--DSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHD 765
                 +  G R P     D  S GH  DSS QS     G R  + +S G+   ++     
Sbjct: 324  SAWEQSRDGSRHPRSHDEDRASHGHSADSSRQS-----GTRHAETSSRGQTASSHEQAR- 377

Query: 766  SSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHS 825
             SS   R+G G +      R      G  S      GH  SS       G +  ++ GHS
Sbjct: 378  -SSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSS-------GSQASDSEGHS 429

Query: 826  LDANSGGHSPNAYSGGRDSS------SNSYDRSHRYGGGGHYEEYRGRSHDTHSR-GRSP 878
             ++++   S +  +G R  S        S +RS R G   +      +    H R G S 
Sbjct: 430  ENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTST 489

Query: 879  DAHSGDHYTEAYSRGRDSFSNSYGRSDHYG-----RGGCYEEYQGRSPNAYGGGRGLNSS 933
                G H+ +A    R S S   G+    G     RGG    +  +S N  G     +S 
Sbjct: 490  GGRQGSHHEQARDSSRHSASQE-GQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSH 548

Query: 934  NNSHGRSH-RYGGGG--------RYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYE 984
              S GRS   +G  G        R EE  G     HSG R     S   S R+   G  +
Sbjct: 549  TTSQGRSDASHGQSGSRSASRQTRNEEQSGDG-TRHSGSRHHEASSQADSSRHSQVGQGQ 607

Query: 985  EYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSG 1044
                           + S+S G S+   R      R   G                SR G
Sbjct: 608  SSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSA-----------QEQSRDG 656

Query: 1045 CRVPR 1049
             R PR
Sbjct: 657  SRHPR 661



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 55/282 (19%), Positives = 90/282 (31%), Gaps = 36/282 (12%)

Query: 779  YEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEE-NRGHSLDANSGGHSPNA 837
            YE  R  +L  +      +++   H  + + +      R     R ++   N G      
Sbjct: 86   YESTRKENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPR 145

Query: 838  YSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHS---RGRSPDAHSGDHYTEAYSRGR 894
             +GG+   S+S  +  +     H EE  G++H   S   + ++ +   GD+      R  
Sbjct: 146  ETGGKRHESSSEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLE 205

Query: 895  DSFSNSYGRSDHYGRG---------GCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGG 945
            +   N  G  D+   G         G    Y      AY     L   N  + RS    G
Sbjct: 206  EKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDG 265

Query: 946  --------------------GGRYEEYRGP--SPDAHSGGR-DSSIKSYGLSDRYGGGGH 982
                                  R  + RG   S D  S G  + S +  G + R   G  
Sbjct: 266  KSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSA 325

Query: 983  YEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRG 1024
            +E+ +       S D DR+S+ +        G        RG
Sbjct: 326  WEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRG 367


>gi|62122917 filaggrin family member 2 [Homo sapiens]
          Length = 2391

 Score =  116 bits (291), Expect = 1e-25
 Identities = 178/743 (23%), Positives = 261/743 (35%), Gaps = 81/743 (10%)

Query: 368  GGRSSSSNGYSRSDRY-GEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEY 426
            G  S  S+G+ +     G+   + ++  RS  +  G   S S+   QS  YG  G   E 
Sbjct: 509  GSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSS---QSSGYGQYGS-RET 564

Query: 427  RGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRS-LDANSGG 485
             G        G+ST     G      SG     S S    G G++E   G+S    +S G
Sbjct: 565  SGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSG 624

Query: 486  CSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSH 545
             S  +  G H +   S     G    ++ G     +  G+S  +  G H S S   GQS 
Sbjct: 625  SSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQS--SGFGQHVSGS---GQS- 678

Query: 546  RYGGEGRYEYRG--RSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANS 603
               G G++E R    S+  H  G S  +  G H SSS   +  G G +E   G+S     
Sbjct: 679  --SGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSS--GQTSGFGQHELSSGQSSSFGQ 734

Query: 604  GGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCY 663
             G      SG     S S +  G G++E   G+S        S  +   G   S Q++ +
Sbjct: 735  HGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGF 794

Query: 664  G----------GGGRYEEYRGRL--LDANSGGRSPDAYSGGHDSSSQSNRYG-GGGRYEE 710
            G          G G+Y    G+      +  G    +  G H+S S  + YG  G    +
Sbjct: 795  GQHGSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQ 854

Query: 711  YRGHSLDANSGGRSPDTYSRGHDSSSQ----SDHYGGGGRSLDANSSGRLPDAYSGGHDS 766
              G+    +S G++   + +   SS Q      H  G G+S      G     YSG    
Sbjct: 855  SSGYGQHGSSSGQT-SGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQH 913

Query: 767  SSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSL 826
             SRSH+             S   +  G S ++  G H SSS      G G++    G S 
Sbjct: 914  ESRSHQ------------SSYGQHGSGSSQSSGYGQHGSSS--GQTFGFGQHRSGSGQSS 959

Query: 827  DANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDH- 885
                 G      SG     S S   S   G G H       ++  H  G S  +  G H 
Sbjct: 960  GFGQHGSGSGQSSGFGQHESGSGKSS---GFGQHESRSSQSNYGQHGSGSSQSSGYGQHG 1016

Query: 886  ----YTEAYSRGRDSFSNSYGRSDH----------------YGRGGCYEEYQGRSPNAYG 925
                 T  + + R S     G   H                 G+   + +Y+ RS  +  
Sbjct: 1017 SSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSY 1076

Query: 926  GGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGL-SDRYGGGGHYE 984
            G  G  SS +S    H    G    +  G        G+ S    YG  S +  G G + 
Sbjct: 1077 GQHGSGSSQSSGYGQH----GSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHG 1132

Query: 985  EYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPL-HDSYSRS 1043
               G        ++    +SYG+    S      G+ + G       G      D++S S
Sbjct: 1133 SGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSS 1192

Query: 1044 GCRVPRGGGRQG-GRFERGEGRS 1065
            G  +   G   G G++  G G+S
Sbjct: 1193 GQHISDSGQSTGFGQYGSGSGQS 1215



 Score =  115 bits (288), Expect = 2e-25
 Identities = 165/743 (22%), Positives = 244/743 (32%), Gaps = 108/743 (14%)

Query: 358  SRDH-SPKAYSGGRSSSSNGYSR-SDRYGEEGCYEEYRGRSPDAHSGGRNSSSN--SYGQ 413
            SR H S     G  SS S+GY +     G+   + ++R  S      G++ S +  S G 
Sbjct: 838  SRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGF 897

Query: 414  SHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEE 473
              H  G G+Y  +    HE+RS   S   H  G S  +  G H SSS      G  R   
Sbjct: 898  GQHGTGSGQYSGFG--QHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGS 955

Query: 474  YQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGG 533
             Q      +  G    +  G H++ S     G G H   +   +   +  G S  +  G 
Sbjct: 956  GQSSGFGQHGSGSGQSSGFGQHESGSGKSS-GFGQHESRSSQSNYGQHGSGSSQSSGYGQ 1014

Query: 534  HSSSS----------NSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSN 583
            H SSS          +S GQ   +G  G    +      H  G    +  G ++S S+ +
Sbjct: 1015 HGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQS 1074

Query: 584  RYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGG-----GRYEEYRGRSL 638
             YG  G        S  + S G   +  + G  S    HR G G     G+Y    G+S 
Sbjct: 1075 SYGQHG--------SGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSS 1126

Query: 639  --------DANSGGRSPDAYSGGHDSSGQ----SNCYGGGGRYEEYRGRLLDANSGGRSP 686
                       S G +   Y  G  S GQ    S+   G G++E   G            
Sbjct: 1127 GFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFGQHVSGS 1186

Query: 687  DAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSG------------GRSPDTYSR---- 730
            D +S      S S +  G G+Y    G S     G            GR   T+ +    
Sbjct: 1187 DNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTHGQTINT 1246

Query: 731  -GHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSH----------RYGGGGRY 779
              H  S Q      G R      S +  ++ S  H   S  H           Y   G  
Sbjct: 1247 TRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQAGSHYPKSGST 1306

Query: 780  EEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSG-GHSP--- 835
               R  +     G  + + +SG   S+       G  R+  +     + +SG  H P   
Sbjct: 1307 VRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQ 1366

Query: 836  ---NAYSGGRDSSSNS---------YDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSG 883
               ++ +G +   S S         Y ++    G GH    +     + + GR    HS 
Sbjct: 1367 EQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQRGSRTTGRRGSGHSE 1426

Query: 884  DHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNA-YGGGRGLNSSNNSHGRSHR 942
               +E +S G         +   +G+ G      G + +  +G   G       H   H 
Sbjct: 1427 SSDSEVHSGGS---HRPQSQEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHH 1483

Query: 943  YGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSG-DHDRS 1001
                 R     G     HS   DS + S        GG H           +SG  H +S
Sbjct: 1484 GKSTQRGSSTTGRRGSGHSESSDSEVHS--------GGSH----------THSGHTHGQS 1525

Query: 1002 SNSYGRSDRYSRGRDRVGRPDRG 1024
             + +G S+     R R+     G
Sbjct: 1526 GSQHGESESIIHDRHRITHGQTG 1548



 Score =  114 bits (286), Expect = 4e-25
 Identities = 199/871 (22%), Positives = 291/871 (33%), Gaps = 124/871 (14%)

Query: 277  GDGNQNGY-----RGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGG------ 325
            G G  +G+     R     Y  H S  S       +G   G    +G   S  G      
Sbjct: 980  GSGKSSGFGQHESRSSQSNYGQHGSGSSQSSGYGQHGSSSGQTTGFGQHRSSSGQYSGFG 1039

Query: 326  --GCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRY 383
              G   ++  G        G+SS        ++ SR  S   +  G S SS         
Sbjct: 1040 QHGSGSDQSSGFGQHGTGSGQSSGFGQY---ESRSRQSSYGQHGSGSSQSSGYGQHGSNS 1096

Query: 384  GEEGCYEEYRGRSPDAHSGGR--NSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTD 441
            G+   + ++R  S  +   G+  + S  S G   H  G G+   +    HE RSG  S  
Sbjct: 1097 GQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGKSSGFA--QHEYRSGQSSYG 1154

Query: 442  AHSRGRSDDAYSGGHDSS-----------SWSDCCGGGGRYEEYQGRSLDANSGGCSPEA 490
             H  G S  +  G H+S            S SD     G++    G+S      G     
Sbjct: 1155 QHGTGSSQSSGCGQHESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQ 1214

Query: 491  YSGGHDNSSWSDRYG--VGGHYEENRGHSLDA---NSGGRSPDTHSGGH-------SSSS 538
             +G     S     G  V G  E   G +++    +  G+   T +G         S S 
Sbjct: 1215 STGLGQGESQQVESGSTVHGRQETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSE 1274

Query: 539  NSYGQSHRYGGEGRYEY---RGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYR 595
            NS  + H        E+   +  SH   SG          H     + R+G  G      
Sbjct: 1275 NSDSEVHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSG-----H 1329

Query: 596  GRSLDANS--GGRSPNAYSGGHDS---SSWSHR----------YGGGGRYEEYRGRSLDA 640
            G+S    S   GR   ++S   DS   S  SHR           G      E        
Sbjct: 1330 GQSTQTGSRTSGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHE 1389

Query: 641  NSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGG-HDSSSQS 699
             + G++ +A   GH   GQS   G         GR    +S     + +SGG H   SQ 
Sbjct: 1390 TTYGQTGEATGHGHSGHGQSTQRG-----SRTTGRRGSGHSESSDSEVHSGGSHRPQSQE 1444

Query: 700  NRYGGGGRYEEYRGHSLDANSG---GRSPDTYSRGHDSSSQSDHYGGG--GRSLDANSSG 754
              +G  G      G ++    G   G++ DT    H    +S   G    GR    +S  
Sbjct: 1445 QTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSES 1504

Query: 755  RLPDAYSGG-HDSSSRSHRYGGGGRYEEY-----RGRSLDANSGGRSPNAYSGGHNSSSR 808
               + +SGG H  S  +H   G    E       R R     +G  + ++YSG   ++  
Sbjct: 1505 SDSEVHSGGSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQT 1564

Query: 809  NDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYG-GGGHYEEYRGR 867
                 G  R   +     + +SGG            S   + R H YG  G  +EE    
Sbjct: 1565 GSRTTGRQRTSHSESTDSEVHSGG------------SHRPHSREHTYGQAGSQHEEPEFT 1612

Query: 868  SHDTH--SRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYG------RGGCYEEYQGR 919
             H+ H  + G+  D     H     S  R S +    RS H          G    + G 
Sbjct: 1613 VHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSGVSHTHTGH 1672

Query: 920  SPNAYGGGRGLNSS--NNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRY 977
            +    G   G + S     HG +H   G      +        +G R +  +        
Sbjct: 1673 THGQAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRR-------- 1724

Query: 978  GGGGHYEEYQGSLPDAYSG-DHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPL 1036
             G GH  EY  S  + YSG  H  S +++G++ R   G       +R   +  +TG    
Sbjct: 1725 -GSGH-SEYSDS--EGYSGVSHTHSGHTHGQA-RSQHGESESIVHERHGTIHGQTGDTTR 1779

Query: 1037 HDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
            H ++S  G +  + G R  GR  R  G S Y
Sbjct: 1780 H-AHSGHG-QSTQTGSRTTGR--RSSGHSEY 1806



 Score =  112 bits (281), Expect = 1e-24
 Identities = 185/849 (21%), Positives = 269/849 (31%), Gaps = 145/849 (17%)

Query: 275  LRGDGNQNGYRGRDHEYTDHPS-------KGSYREPLKSYGGPCGAAPVWGTPPSY--GG 325
            L   GNQ G + R H  +   S        GS    L+        +P   +   Y  G 
Sbjct: 168  LSSSGNQEGSQKRYHRSSCGHSWSGGKDRHGSSSVELRERINKSHISPSRESGEEYESGS 227

Query: 326  GCRYEEYQGNSPDAC---SEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDR 382
            G    E +G+   +C   + G  S +    + +         +   GR S + GYS S  
Sbjct: 228  GSNSWERKGHGGLSCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSNSS- 286

Query: 383  YGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEY----------RGRSHE 432
                GC              GR  +++S  QSH +GG+G    Y           G+ H 
Sbjct: 287  ----GC--------------GRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHG 328

Query: 433  ARSGG-------------------RSTDAHSRGRSDDAYSGGHDSSSWSDCCG----GGG 469
              SGG                   R   A   G+  +        SS S CCG    GG 
Sbjct: 329  CVSGGQPSGCGQPESNPCSQSYSQRGYGARENGQPQNCGGQWRTGSSQSSCCGQYGSGGS 388

Query: 470  R-----YEEYQGRSLDANSGGCSP----EAYSGGHDNSSWSDRYGVG------------- 507
            +       EY      +NS   +     + Y  G   S+  +++G G             
Sbjct: 389  QSCSNGQHEYGSCGRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQSSGFEQHVCG 448

Query: 508  -----GHYEENRGHSLDANSGGRSPDTHSG------------GHSSSSNSYGQSHRYGGE 550
                 G +E     SL  +  G S    SG            G     +  GQS  +G  
Sbjct: 449  SGQTCGQHESTSSQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGFGQCGSGSGQSSGFGQH 508

Query: 551  GRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGC-------YEEY--------- 594
            G    +      H       +  G H+S S+ + YG  G        Y +Y         
Sbjct: 509  GSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFG 568

Query: 595  -----RGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDA 649
                  G+S      G      SG     S S +  G G++E   G+S        S  +
Sbjct: 569  QHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQS 628

Query: 650  YSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYE 709
               G   S Q++ +G  G             SG      +      S QS+   G G++E
Sbjct: 629  SGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSS---GFGQHE 685

Query: 710  EYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSR 769
               GHS     G  S  +   G   SS     G G   L +  S       SG   SS  
Sbjct: 686  SRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGF 745

Query: 770  SHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDAN 829
                 G G+   +     ++ SG  S   +S G + SS      G G++   +      +
Sbjct: 746  GQHGSGSGQSSGFGQH--ESRSGQSSYGQHSSGSSQSS------GYGQHGSRQTSGFGQH 797

Query: 830  SGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAH-SGDHYTE 888
              G S +   G   S S       ++G G       G+ H++ S   S   H SG   + 
Sbjct: 798  GSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQ-HESRSHQSSYGQHGSGSSQSS 856

Query: 889  AYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGR-SHRYGGGG 947
             Y +   S   + G   H    G Y  +       +G G G +S    HG  S +Y G G
Sbjct: 857  GYGQHGSSSGQTSGFGQHRSSSGQYSGF-----GQHGSGSGQSSGFGQHGTGSGQYSGFG 911

Query: 948  RYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGG--GHYEEYQGSLPDAYSGDHDRSSNSY 1005
            ++E     S     G   S    YG      G   G  +   GS   +  G H   S   
Sbjct: 912  QHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQS 971

Query: 1006 GRSDRYSRG 1014
                ++  G
Sbjct: 972  SGFGQHESG 980



 Score =  112 bits (280), Expect = 2e-24
 Identities = 191/756 (25%), Positives = 268/756 (35%), Gaps = 98/756 (12%)

Query: 370  RSSSSNGYSRSDRYGEEGCY-EEYRGRSPDAHSGGRNSSSNSYGQSHHY-GGEGRYEEYR 427
            ++S S  + R  R+ EE    EE    +P   SG R+SS  S G+ H Y  G  R     
Sbjct: 95   KASGSKKHRRGHRHQEEESETEEDEEDTPGHKSGYRHSSW-SEGEEHGYSSGHSRGTVKC 153

Query: 428  GRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLD-ANSGGC 486
                 +R  GR  +  S G  + +    H SS      GG  R+        +  N    
Sbjct: 154  RHGSNSRRLGRQGNLSSSGNQEGSQKRYHRSSCGHSWSGGKDRHGSSSVELRERINKSHI 213

Query: 487  SP-----EAYSGGHDNSSWSDRYGVGG-----------------HYEENRGHSLDANSGG 524
            SP     E Y  G  ++SW +R G GG                    E +  S  + SG 
Sbjct: 214  SPSRESGEEYESGSGSNSW-ERKGHGGLSCGLETSGHESNSTQSRIREQKLGSSCSGSGD 272

Query: 525  RSPDTHSGGHSSSS--------NSYGQSHRYGGEG-RYEY-RGRSHDAHSGGCSADAYSG 574
                +H+ G+S+SS        +S  QSHR+GG+G ++ Y +        GG      SG
Sbjct: 273  SGRRSHACGYSNSSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSG 332

Query: 575  GHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNA---YSGGHDSSSWSHRYGGGGRYE 631
            G  S     +     C + Y  R   A   G+  N    +  G   SS   +YG GG   
Sbjct: 333  GQPSG--CGQPESNPCSQSYSQRGYGARENGQPQNCGGQWRTGSSQSSCCGQYGSGGSQS 390

Query: 632  EYRGRSLDANSGGRSPDAYSGGHDSSGQSNC--YGGGGRYE---EYRGRLLDANSGGRSP 686
               G+  +  S GR    +S    S+  S C  YG G       E  G  L  +SG    
Sbjct: 391  CSNGQH-EYGSCGR----FSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQSSGFEQH 445

Query: 687  DAYSG---GHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYG- 742
               SG   G   S+ S   G    Y+++ G S    SG      + +    S QS  +G 
Sbjct: 446  VCGSGQTCGQHESTSSQSLG----YDQH-GSSSGKTSG------FGQHGSGSGQSSGFGQ 494

Query: 743  ---GGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAY 799
               G G+S      G +    SG     S S +  G G++E  R R       G   +  
Sbjct: 495  CGSGSGQSSGFGQHGSVSGQSSGFGQHGSVSGQSSGFGQHES-RSRQSSYGQHGSGSSQS 553

Query: 800  SGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGG 859
            SG     SR     G G++    G S      G      SG     S S   S    G G
Sbjct: 554  SGYGQYGSRE--TSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQHGSGSGQSS----GFG 607

Query: 860  HYEEYRGR-SHDTHSRGRSPDAHSGDH---YTEAYSRGRDSFSNSYGRSDHYGRGGCYEE 915
             +E   G+ S+  HS G S  +  G H    T  + +     S S G    YG G     
Sbjct: 608  QHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTG-FGQYGSGSGQSS 666

Query: 916  YQGR--SPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGP--SPDAHSGGRDSSIKSY 971
              G+  S +    G G + S + H    ++G G       G   S    + G      S 
Sbjct: 667  GFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSS 726

Query: 972  GLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMET 1031
            G S  +G  G      GS   +  G H   S   G+S  + +   R G+   G      +
Sbjct: 727  GQSSSFGQHG-----SGSGQSSGFGQHGSGS---GQSSGFGQHESRSGQSSYG----QHS 774

Query: 1032 GSPPLHDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
                    Y + G R   G G+ G    +  G  +Y
Sbjct: 775  SGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQY 810



 Score =  112 bits (280), Expect = 2e-24
 Identities = 174/787 (22%), Positives = 260/787 (33%), Gaps = 115/787 (14%)

Query: 360  DHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRN---SSSNSYGQ--S 414
            D +  +YSG   ++  G   + R  +   + E      + HSGG +   S  ++YGQ  S
Sbjct: 1549 DTTRHSYSGHEQTTQTGSRTTGR--QRTSHSE--STDSEVHSGGSHRPHSREHTYGQAGS 1604

Query: 415  HHYGGEGRYEEYRGRSH--------EARSG-GRSTDAHSR--GRSDDAYSGGHDSSSWSD 463
             H   E    E  G +H         + SG G+ST   SR  GR   ++S   DS   S 
Sbjct: 1605 QHEEPEFTVHERHGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHSESSDSEVHSG 1664

Query: 464  CCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSG 523
                   +   Q  S    S    PE +   H  +  + R+    HY     H L   +G
Sbjct: 1665 VSHTHTGHTHGQAGSQHGQSESIVPERHGTTHGQTGDTTRHA---HYH----HGLTTQTG 1717

Query: 524  GRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSG-GHDSSSQS 582
             R+      GHS  S+S G            Y G SH  HSG     A S  G   S   
Sbjct: 1718 SRTTGRRGSGHSEYSDSEG------------YSGVSH-THSGHTHGQARSQHGESESIVH 1764

Query: 583  NRYG------GGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGR 636
             R+G      G      + G      +G R+    S GH   S S  + G  +    RG 
Sbjct: 1765 ERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQRPHSRGH 1824

Query: 637  SLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSS 696
            +    +G +  ++ S   +  G ++   G        G      SG  +      GH  S
Sbjct: 1825 T-HGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSES 1883

Query: 697  SQSNRYGGGGRYEEYRGHSLDANSGGRSP---------------DTYSRGHDSSSQSDHY 741
            S S  + GG        HS   +  G S                DT   GH S  Q+   
Sbjct: 1884 SDSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQTTHGQTGDTTEHGHPSHGQTIQT 1943

Query: 742  G-------GGGRSLDANSSG------------------RLPDAYSGGHDSSSRSHRYGGG 776
            G       G G S  ++S G                    P++ S  H+    +H     
Sbjct: 1944 GSRTTGRRGSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPESGSSVHERHGTTHGQTAD 2003

Query: 777  GRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPN 836
                 + G       G R+    + GH+  S ++   G         H    +  G S +
Sbjct: 2004 TTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGESGS 2063

Query: 837  AYSGGRDSSSNSYDRSHRYGGGGHYEEYR------GRSHDTHSRGRSPDAHSG-DHYTEA 889
            +      ++      + R+   GH +  +      GR    HS     + HSG  H    
Sbjct: 2064 SVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSG 2123

Query: 890  YSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSH--GRSHRYGGGG 947
            ++ G+    +    S  +GR G      G +      G G ++   S   GR        
Sbjct: 2124 HTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQSGHGQSTQTGSRTTGRQRSSHSES 2183

Query: 948  RYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGR 1007
               E    +   HSG   S   S     R+G  G     +       +GD  R ++ YG 
Sbjct: 2184 SDSEVHSEASPTHSGHTHSQAGS-----RHGQSGSSGHGRQGTTHGQTGDTTRHAH-YGY 2237

Query: 1008 SDRYSRGRDRVGRPDRGLPLPMETGSPPLHD--SYSRSGCRVPRGGGRQ-------GGRF 1058
                 RG    GR   G     E+    +H   S++ SG    + G +Q        GR 
Sbjct: 2238 GQSTQRGSRTTGRRGSG---HSESSDSEVHSWGSHTHSGHIQGQAGSQQRQPGSTVHGRL 2294

Query: 1059 ERGEGRS 1065
            E   G++
Sbjct: 2295 ETTHGQT 2301



 Score =  107 bits (268), Expect = 5e-23
 Identities = 185/829 (22%), Positives = 273/829 (32%), Gaps = 120/829 (14%)

Query: 277  GDGNQNGY-----RGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEE 331
            G G  +G+     R     Y  H S  S       +G   G    +G   S  G     +
Sbjct: 826  GSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSG-----Q 880

Query: 332  YQGNSPDACSEGRSSE-ALPVVLPDAYSR--DHSPKAYSGGRSSSSNGYSRSDRYGEEGC 388
            Y G        G+SS           YS    H  +++        +G S+S  YG+ G 
Sbjct: 881  YSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGS 940

Query: 389  YEEY-----RGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRS-----HEARSGGR 438
                     + RS    S G     +  GQS    G G++E   G+S     HE+RS   
Sbjct: 941  SSGQTFGFGQHRSGSGQSSGFGQHGSGSGQS---SGFGQHESGSGKSSGFGQHESRSSQS 997

Query: 439  STDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSG-GHDN 497
            +   H  G S  +  G H SSS      G G++    G+       G   +  SG G   
Sbjct: 998  NYGQHGSGSSQSSGYGQHGSSSGQTT--GFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHG 1055

Query: 498  SSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSN----------SYGQSHRY 547
            +      G G +   +R  S   +  G S  +  G H S+S             GQS  +
Sbjct: 1056 TGSGQSSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGF 1115

Query: 548  GGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYG--------GGGCYEEYRG--- 596
            G  G    +      H  G    +    H+  S  + YG          GC +   G   
Sbjct: 1116 GQYGSGSGQSSGFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGP 1175

Query: 597  -RSLDANSGGRSPNAYSGGHDSSSWSH----RYGGGGRYEE--YRGRSLDANSG----GR 645
              S   +  G    + SG H S S       +YG G        +G S    SG    GR
Sbjct: 1176 TTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGR 1235

Query: 646  SPDAY-----SGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSN 700
                +     +  H  SGQ      G R    R      NS        S  H     + 
Sbjct: 1236 QETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSEVHSKVSHRHSEHIHTQ 1295

Query: 701  RYGGGGRYEEYRGHSLDANSG---GRSPDTYSRGHDSSSQSDHYGG--GGRSLDANSSGR 755
                 G +    G ++    G   G+  DT   GH    QS   G    GR   ++S   
Sbjct: 1296 ----AGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRTSGRQRFSHSDAT 1351

Query: 756  LPDAYSG-GHDSSSRSHRYG-GGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR 813
              + +SG  H   S+   +   G ++ E      + +         + GH  S      +
Sbjct: 1352 DSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEATGHGHSGHGQSTQ 1411

Query: 814  GGGRYEENR--GHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEE---YRGRS 868
             G R    R  GHS  ++S  HS      G      S +++H   G  H E      GR 
Sbjct: 1412 RGSRTTGRRGSGHSESSDSEVHS------GGSHRPQSQEQTHGQAGSQHGESGSTVHGRH 1465

Query: 869  HDTHSRGRSPDAHSGDHYTEAYSRGRDSF----SNSYGRSDHYGRGGCYEEYQGRSPNAY 924
              TH +      H+  H+ ++  RG  +     S     SD     G    + G +    
Sbjct: 1466 GTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSGHTHGQS 1525

Query: 925  GGGRGLNSS------NNSHGRS-----HRYGG-----------GGRYEEYRGPSPDA--H 960
            G   G + S        +HG++     H Y G            GR       S D+  H
Sbjct: 1526 GSQHGESESIIHDRHRITHGQTGDTTRHSYSGHEQTTQTGSRTTGRQRTSHSESTDSEVH 1585

Query: 961  SGGRDSSIKSYGLSDRYG-GGGHYEEYQGSLPDAYSGDHDRSSNSYGRS 1008
            SGG   S + +     YG  G  +EE + ++ + +   H +  ++ G S
Sbjct: 1586 SGG---SHRPHSREHTYGQAGSQHEEPEFTVHERHGTTHGQIGDTTGHS 1631



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 91/418 (21%), Positives = 133/418 (31%), Gaps = 76/418 (18%)

Query: 257  RDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPV 316
            R   RR  GHS   D     G  + +         + H   GS     + +G   G    
Sbjct: 2021 RTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGESGSSVH--ERHGTTHGQT-- 2076

Query: 317  WGTPPSYGGGCRYEEYQGNSPDACSEGRS-SEALPVVLPDAYSRDHSPKAYSGGRSSSSN 375
             G    +      +  Q  S  A   G   SE+    +    S  HS   Y  G++ S +
Sbjct: 2077 -GDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEVHSGVSHTHSGHTY--GQARSQH 2133

Query: 376  GYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHE--A 433
            G S S  +G +G               G+   +  +GQS H           G+S +  +
Sbjct: 2134 GESGSAIHGRQGTIH------------GQTGDTTRHGQSGH-----------GQSTQTGS 2170

Query: 434  RSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSG 493
            R+ GR   +HS     + +S    + S       G R+           SG         
Sbjct: 2171 RTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRH---------GQSGSSGHGRQGT 2221

Query: 494  GHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGG---E 550
             H  +  + R+    HY    G+      G R+      GHS SS+S  + H +G     
Sbjct: 2222 THGQTGDTTRH---AHY----GYGQSTQRGSRTTGRRGSGHSESSDS--EVHSWGSHTHS 2272

Query: 551  GRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNA 610
            G  + +  S     G          H  +  + R+G       + G      +G RS  A
Sbjct: 2273 GHIQGQAGSQQRQPGSTVHGRLETTHGQTGDTTRHG-------HSGYGQSTQTGSRSSRA 2325

Query: 611  YSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGR 668
                H  S  S R        +  G S     G   P  Y  GH   G S    GG R
Sbjct: 2326 ---SHFQSHSSER--------QRHGSSQVWKHGSYGPAEYDYGHTGYGPS----GGSR 2368



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 66/309 (21%), Positives = 102/309 (33%), Gaps = 34/309 (11%)

Query: 276  RGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGN 335
            RG G+        H    H   G      +S  G  G+A + G         R     G 
Sbjct: 2101 RGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSA-IHG---------RQGTIHGQ 2150

Query: 336  SPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGR 395
            + D    G+S            SR    +  S   SS S  +S +        + +   R
Sbjct: 2151 TGDTTRHGQSGHGQST---QTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSR 2207

Query: 396  SPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGG 455
               + S G      ++GQ+        Y   +     +R+ GR    HS     + +S G
Sbjct: 2208 HGQSGSSGHGRQGTTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGHSESSDSEVHSWG 2267

Query: 456  HDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRG 515
              + S     G  G  +   G ++               H  +  + R+G       + G
Sbjct: 2268 SHTHS-GHIQGQAGSQQRQPGSTVHGR--------LETTHGQTGDTTRHG-------HSG 2311

Query: 516  HSLDANSGGRSP-DTHSGGHSSSSNSYGQSH--RYGGEGRYEY-RGRSHDAHSGGCSADA 571
            +     +G RS   +H   HSS    +G S   ++G  G  EY  G +    SGG S  +
Sbjct: 2312 YGQSTQTGSRSSRASHFQSHSSERQRHGSSQVWKHGSYGPAEYDYGHTGYGPSGG-SRKS 2370

Query: 572  YSGGHDSSS 580
             S  H S S
Sbjct: 2371 ISNSHLSWS 2379


>gi|239757825 PREDICTED: hypothetical protein XP_002346350 [Homo
            sapiens]
          Length = 196

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 52/91 (57%), Positives = 58/91 (63%), Gaps = 3/91 (3%)

Query: 977  YGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPL 1036
            YGG   Y++Y  S  D Y G  D  S+S  RSD YS GRD+VGR +RGLP  ME G PP 
Sbjct: 109  YGGSSRYDDYSSSR-DGYGGSRDSYSSS--RSDLYSSGRDQVGRQERGLPPSMERGYPPP 165

Query: 1037 HDSYSRSGCRVPRGGGRQGGRFERGEGRSRY 1067
             DSYS S    PRGGGR G R +RG GRSRY
Sbjct: 166  RDSYSSSSRGTPRGGGRGGSRSDRGGGRSRY 196



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 37/109 (33%), Positives = 44/109 (40%), Gaps = 14/109 (12%)

Query: 682 GGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHY 741
           G R P   S  +  +  S  YGG  RY++Y   S D   G R   + SR    SS  D  
Sbjct: 91  GNRCPLVESSTYTRAPPS--YGGSSRYDDYSS-SRDGYGGSRDSYSSSRSDLYSSGRDQV 147

Query: 742 GGGGRSLDANSSGRLP---DAYS--------GGHDSSSRSHRYGGGGRY 779
           G   R L  +     P   D+YS        GG    SRS R GG  RY
Sbjct: 148 GRQERGLPPSMERGYPPPRDSYSSSSRGTPRGGGRGGSRSDRGGGRSRY 196



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 41/125 (32%), Positives = 49/125 (39%), Gaps = 41/125 (32%)

Query: 320 PPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSR 379
           PPSYGG  RY++Y                         SRD     Y G R S S+  SR
Sbjct: 106 PPSYGGSSRYDDYSS-----------------------SRD----GYGGSRDSYSS--SR 136

Query: 380 SDRY--GEEGCYEEYRGRSPDAHSG---GRNSSSNSYGQSHHYGGEGRYEEYRGRSHEAR 434
           SD Y  G +    + RG  P    G    R+S S+S   +   GG       RG S   R
Sbjct: 137 SDLYSSGRDQVGRQERGLPPSMERGYPPPRDSYSSSSRGTPRGGG-------RGGSRSDR 189

Query: 435 SGGRS 439
            GGRS
Sbjct: 190 GGGRS 194



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 43/156 (27%), Positives = 60/156 (38%), Gaps = 27/156 (17%)

Query: 497 NSSWSDRYGVGGHYEENRGHSLDAN------SGGRSPDTHSGGHSSSSNSYGQSHRYGGE 550
           N  W D++ V   +EE   + ++         G R P   S  ++ +  SYG      G 
Sbjct: 60  NKKW-DQFAVAVEWEEELLYHVEEIVTEVHLEGNRCPLVESSTYTRAPPSYG------GS 112

Query: 551 GRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNA 610
            RY+    S D + G  S D+Y     SSS+S+ Y  G      + R L  +     P  
Sbjct: 113 SRYDDYSSSRDGYGG--SRDSY-----SSSRSDLYSSGRDQVGRQERGLPPSMERGYPPP 165

Query: 611 YSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRS 646
                 SS  + R GG       RG S     GGRS
Sbjct: 166 RDSYSSSSRGTPRGGG-------RGGSRSDRGGGRS 194



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 33/112 (29%), Positives = 45/112 (40%), Gaps = 13/112 (11%)

Query: 860 HYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSF-----SNSYGRSDHY--GRGGC 912
           H E  R    ++ +  R+P ++ G    + YS  RD +     S S  RSD Y  GR   
Sbjct: 88  HLEGNRCPLVESSTYTRAPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSGRDQV 147

Query: 913 YEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGR 964
             + +G  P+   G      S +S  R    GGG      RG S     GGR
Sbjct: 148 GRQERGLPPSMERGYPPPRDSYSSSSRGTPRGGG------RGGSRSDRGGGR 193



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 36/111 (32%), Positives = 44/111 (39%), Gaps = 26/111 (23%)

Query: 417 YGGEGRYEEYRGRSHEARSG-GRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQ 475
           YGG  RY++Y      +R G G S D++S  RS D YS G D           GR E   
Sbjct: 109 YGGSSRYDDY----SSSRDGYGGSRDSYSSSRS-DLYSSGRDQV---------GRQERGL 154

Query: 476 GRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRS 526
             S++          Y    D+ S S R   G      RG S     GGRS
Sbjct: 155 PPSME--------RGYPPPRDSYSSSSR---GTPRGGGRGGSRSDRGGGRS 194



 Score = 30.4 bits (67), Expect = 9.3
 Identities = 29/86 (33%), Positives = 39/86 (45%), Gaps = 3/86 (3%)

Query: 898 SNSYGRSD-HYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPS 956
           S++Y R+   YG    Y++Y   S + YGG R   SS+ S   S      GR E    PS
Sbjct: 99  SSTYTRAPPSYGGSSRYDDYSS-SRDGYGGSRDSYSSSRSDLYSSGRDQVGRQERGLPPS 157

Query: 957 PD-AHSGGRDSSIKSYGLSDRYGGGG 981
            +  +   RDS   S   + R GG G
Sbjct: 158 MERGYPPPRDSYSSSSRGTPRGGGRG 183


>gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens]
          Length = 592

 Score = 92.0 bits (227), Expect = 3e-18
 Identities = 165/645 (25%), Positives = 224/645 (34%), Gaps = 105/645 (16%)

Query: 406  SSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCC 465
            S S SYGQS   GGE +     G       G  S      G++ D+  G           
Sbjct: 2    SDSGSYGQS---GGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYG----------- 47

Query: 466  GGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANS--G 523
                  + Y G S    S     ++Y GG++N   S  Y    +  + +  +++++   G
Sbjct: 48   ------QNYSGYSSYGQSQSGYSQSY-GGYENQKQSS-YSQQPYNNQGQQQNMESSGSQG 99

Query: 524  GRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSN 583
            GR+P       S     YGQ   Y  +  Y+    S+D  S       Y   HDS SQ+ 
Sbjct: 100  GRAP-------SYDQPDYGQQDSYDQQSGYDQHQGSYDEQSN------YDQQHDSYSQNQ 146

Query: 584  RYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSG 643
            +      + +    S       R  + Y  G D+  +    GGG      RGR    +  
Sbjct: 147  Q----SYHSQRENYSHHTQDDRRDVSRY--GEDNRGYGGSQGGG------RGRG-GYDKD 193

Query: 644  GRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPD---AYSGGHDSSSQSN 700
            GR P   S G D  G  N +GG   Y    G   DA+S   + D    +  G      ++
Sbjct: 194  GRGPMTGSSGGDRGGFKN-FGGHRDY----GPRTDADSESDNSDNNTIFVQGLGEGVSTD 248

Query: 701  RYG------GGGRYEEYRGHSL-----DANSG---GRSPDTYSRGHDSSSQSDHYGGG-- 744
            + G      G  +  +  G  +     D ++G   G +  ++     + +  D + G   
Sbjct: 249  QVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEF 308

Query: 745  -GRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGR-SPNAYSGG 802
             G  +  + + R P+   GG     R  R G  GR   ++GR  D  SG    PN   G 
Sbjct: 309  HGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGR-GGFQGRGGDPKSGDWVCPNPSCGN 367

Query: 803  HNSSSRNDPCR--GGGRYEENRGHSLDANS---GGHSPNAYSGGRDSSSNSYDRSHRYGG 857
             N + RN  C      R E++R    D      GG       GGR      Y      GG
Sbjct: 368  MNFARRNS-CNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGG 426

Query: 858  -GGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEY 916
             GG      G S D    G   D   G +  +            YG     G GG    Y
Sbjct: 427  YGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGY 486

Query: 917  QGRSPNAYGGGRGLNSSNNSHGRSHRYGG--GGRYEEYRGPSPDAHSGGRDSSIKSYGLS 974
             G     YGG RG             YGG  GG   +  G   D    G D S   YG  
Sbjct: 487  GGDRGGGYGGDRG------------GYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYG-G 533

Query: 975  DRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVG 1019
            DR GG G    Y G     Y G  DRS   YG       G DR G
Sbjct: 534  DRGGGSG----YGGDRSGGYGG--DRSGGGYGGDRGGGYGGDRGG 572



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 147/628 (23%), Positives = 216/628 (34%), Gaps = 85/628 (13%)

Query: 360 DHSPKAYSGGRSSSSNGYSR--SDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHY 417
           D      SGG   S + Y    S  YG+        G++ D+  G   S  +SYGQS   
Sbjct: 3   DSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQ-- 60

Query: 418 GGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY--- 474
              G  + Y G  ++ +S       +++G+  +  S G            GGR   Y   
Sbjct: 61  --SGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQ----------GGRAPSYDQP 108

Query: 475 ---QGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHS 531
              Q  S D  SG    + + G +D  S  D+        +   HS   N    + D   
Sbjct: 109 DYGQQDSYDQQSG---YDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRR 165

Query: 532 --GGHSSSSNSYGQSHRYG-GEGRYEYRGRSHDAHSGGCSADAYS--GGH-------DSS 579
               +   +  YG S   G G G Y+  GR     S G     +   GGH       D+ 
Sbjct: 166 DVSRYGEDNRGYGGSQGGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHRDYGPRTDAD 225

Query: 580 SQSNRYGGGGCYEEYRGRSLDANSGGR--------SPNAYSGGHDSSSWSHRYGGGGRYE 631
           S+S+       + +  G  +  +  G           N  +G    + ++ +  G  + E
Sbjct: 226 SESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGE 285

Query: 632 EYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSG 691
                  D  S   + D + G                 +E+ G ++  +   R P+   G
Sbjct: 286 ATVSFD-DPPSAKAAIDWFDG-----------------KEFHGNIIKVSFATRRPEFMRG 327

Query: 692 GHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQ--SDHYGGGGRSLD 749
           G     +  R G  GR   ++G   D  SG       S G+ + ++  S +     R  D
Sbjct: 328 GGSGGGRRGRGGYRGR-GGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQCNEPRPED 386

Query: 750 ANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRN 809
           +  SG     + G      R +R G GGR  +  G   D + GG   +  SGG  S  R+
Sbjct: 387 SRPSG---GDFRGRGYGGERGYR-GRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRS 442

Query: 810 ----DPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSY--DRSHRYGG--GGHY 861
                  R GG Y  +RG     + GG       GG       Y  DR   YGG  GG+ 
Sbjct: 443 GGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYG 502

Query: 862 EEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSP 921
            +  G   D    G     + GD     Y   R    + YG     G GG       RS 
Sbjct: 503 GDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGG-GSGYGGDRSGGYGG------DRSG 555

Query: 922 NAYGGGRGLNSSNNSHGRSHRYGGGGRY 949
             YGG RG     +  G   + GG   Y
Sbjct: 556 GGYGGDRGGGYGGDRGGYGGKMGGRNDY 583



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 157/605 (25%), Positives = 222/605 (36%), Gaps = 117/605 (19%)

Query: 259 YSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSY-----REPLKSYGGPCGA 313
           Y + Y G+SS    +     G    Y G +++     S+  Y     ++ ++S G   G 
Sbjct: 46  YGQNYSGYSSYGQSQ----SGYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGR 101

Query: 314 APVWGTPP-----SYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSG 368
           AP +  P      SY     Y+++QG+  +  +  +          D+YS++   ++Y  
Sbjct: 102 APSYDQPDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQH--------DSYSQNQ--QSYHS 151

Query: 369 GRSSSSNGYSRSDR-----YGEE-----GCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYG 418
            R + S+ +++ DR     YGE+     G     RGR       GR   + S G     G
Sbjct: 152 QRENYSH-HTQDDRRDVSRYGEDNRGYGGSQGGGRGRG-GYDKDGRGPMTGSSG-----G 204

Query: 419 GEGRYEEYRGRSHEARSGGRSTDAHSRGRSDD---AYSGGHDSSSWSDCCG------GGG 469
             G ++ + G     R  G  TDA S   + D    +  G      +D  G      G  
Sbjct: 205 DRGGFKNFGGH----RDYGPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGII 260

Query: 470 RYEEYQGRSL-----DANSGGCSPEAYSGGHDNSS------WSDRYGVGGHYEENRGHSL 518
           +  +  G+ +     D ++G    EA     D  S      W D        +E  G+ +
Sbjct: 261 KTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDG-------KEFHGNII 313

Query: 519 DANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDS 578
             +   R P+   GG S      G+  R G  GR  ++GR  D  SG       S G+ +
Sbjct: 314 KVSFATRRPEFMRGGGSGG----GRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMN 369

Query: 579 SSQSNRYGGGGCYEEYRGRSLDAN-SGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRS 637
            ++ N      C +    R  D+  SGG       GG          G GGR  +  G  
Sbjct: 370 FARRN-----SCNQCNEPRPEDSRPSGGDFRGRGYGGERGYR-----GRGGRGGDRGGYG 419

Query: 638 LDANSGGRSPDAYSGGHDSSGQSNC-YGG---GGRYEEYRGRLLDANSGGRSPDAYSGGH 693
            D + GG   D  SGG  S  +S   YGG   GG Y   RG       GG   D   GG 
Sbjct: 420 GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRG-------GGYGGDR--GGG 470

Query: 694 DSSSQSNRYGGG-GRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGG--GGRSLDA 750
               +   YGG  G Y   RG     + GG   D    G D       YGG  GG   D 
Sbjct: 471 YGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGG----YGGDRGGYGGDR 526

Query: 751 NSSGRLPDAYSGGHDSSSRSHRYGG---GGRYEEYRGRSLDANSGGRSPNAYSG--GHNS 805
           +  G   D   G      RS  YGG   GG Y   RG     + GG     Y G  G  +
Sbjct: 527 SRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGG-----YGGKMGGRN 581

Query: 806 SSRND 810
             RND
Sbjct: 582 DYRND 586



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 83/318 (26%), Positives = 102/318 (32%), Gaps = 60/318 (18%)

Query: 275 LRGDGNQNGYRGRDHEYTDHPSKGSYREP--LKSYGGPCGAAPVWGTPPSYGGGCRYEEY 332
           +RG G+  G RGR          G YR     +  GG   +   W  P    G   +   
Sbjct: 325 MRGGGSGGGRRGR----------GGYRGRGGFQGRGGDPKSGD-WVCPNPSCGNMNFA-- 371

Query: 333 QGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEY 392
           + NS + C+E R  ++ P                SGG      GY      GE G    Y
Sbjct: 372 RRNSCNQCNEPRPEDSRP----------------SGG-DFRGRGYG-----GERG----Y 405

Query: 393 RGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAY 452
           RGR      GGR      YG     GG G      G      SG RS   +   RS   Y
Sbjct: 406 RGR------GGRGGDRGGYGGDRSGGGYGGDRSSGG----GYSGDRSGGGYGGDRSGGGY 455

Query: 453 SGGHDSSSWSDCCGG-----GGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWS-DRYGV 506
            G        D  GG     GG Y   +G       GG   +    G D   +  DR G 
Sbjct: 456 GGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGY 515

Query: 507 GGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGG 566
           GG   +  G+  D + GG   D   G       S G      G G    RG  +    GG
Sbjct: 516 GG---DRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGG 572

Query: 567 CSADAYSGGHDSSSQSNR 584
                       + Q NR
Sbjct: 573 YGGKMGGRNDYRNDQRNR 590



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 113/430 (26%), Positives = 138/430 (32%), Gaps = 86/430 (20%)

Query: 10  LFIGGLN--LKTDEKALKAEFGKYGHIIK---------VFLMKDRKTNKSRGFAFVTFES 58
           +F+ GL   + TD+     EF K   IIK         + L  D+ T K +G A V+F+ 
Sbjct: 236 IFVQGLGEGVSTDQVG---EFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDD 292

Query: 59  PADAKAAARDMNGKYLDGKAIMVA-QTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSS 117
           P  AKAA    +GK   G  I V+  T +P F          G G R R  +R RGG   
Sbjct: 293 PPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRG----GGSGGGRRGRGGYRGRGG--- 345

Query: 118 PQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCG 177
                 QGR  D +    +    P    M   R         P  + + PS      G  
Sbjct: 346 -----FQGRGGDPKS-GDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPS------GGD 393

Query: 178 MRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGP 237
            RG+     G+ GY G   R   G        RS      G G  G   +     GYSG 
Sbjct: 394 FRGRG--YGGERGYRGRGGR--GGDRGGYGGDRS------GGGYGGDRSS---GGGYSGD 440

Query: 238 RVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSK 297
           R        R  G             YG      Y   RG G   G RG           
Sbjct: 441 RSGGGYGGDRSGGG------------YGGDRGGGYGGDRG-GGYGGDRG----------- 476

Query: 298 GSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAY 357
           G Y      YGG  G     G    YGG     +  G   D    G             Y
Sbjct: 477 GGYGGDRGGYGGDRGGG-YGGDRGGYGG-----DRGGYGGDRGGYGGDR--------GGY 522

Query: 358 SRDHSPKAYSGGRSSSSN-GYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHH 416
             D S   Y G R   S  G  RS  YG +     Y G     + G R       G  + 
Sbjct: 523 GGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRND 582

Query: 417 YGGEGRYEEY 426
           Y  + R   Y
Sbjct: 583 YRNDQRNRPY 592



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 76/290 (26%), Positives = 94/290 (32%), Gaps = 46/290 (15%)

Query: 207 AVPRSSLARIGGSGMPGKAPAVW-GQDGYSG----PRVREPLPPCRDPGDFVPALRDYSR 261
           A  R    R GGSG   +    + G+ G+ G    P+  + + P    G+   A R+ S 
Sbjct: 318 ATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRN-SC 376

Query: 262 RYYGHSSVPDYRPLRGD------GNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAP 315
                    D RP  GD      G + GYRGR     D    G  R    S GG      
Sbjct: 377 NQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDR----SGGG------ 426

Query: 316 VWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSN 375
            +G   S GGG     Y G+       G  S          Y  D     Y G R     
Sbjct: 427 -YGGDRSSGGG-----YSGDRSGGGYGGDRSGG-------GYGGDRGG-GYGGDRGGGYG 472

Query: 376 GYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARS 435
           G       G+ G Y   RG       GG       YG     G  G Y   RG       
Sbjct: 473 GDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYG-----GDRGGYGGDRG----GYG 523

Query: 436 GGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGG 485
           G RS   +   R   +  GG  S  +     GGG Y   +G     + GG
Sbjct: 524 GDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGG-YGGDRGGGYGGDRGG 572


>gi|5803137 RNA binding motif protein 3 [Homo sapiens]
          Length = 157

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 57/136 (41%), Positives = 73/136 (53%), Gaps = 23/136 (16%)

Query: 9   KLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADAKAAARD 68
           KLF+GGLN  TDE+AL+  F  +G I +V ++KDR+T +SRGF F+TF +P  A  A R 
Sbjct: 7   KLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASVAMRA 66

Query: 69  MNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQ---RPPSQG 125
           MNG+ LDG+ I V      A KS+R                 TRGGG       R  S+G
Sbjct: 67  MNGESLDGRQIRVDH----AGKSAR----------------GTRGGGFGAHGRGRSYSRG 106

Query: 126 RPDDGRGYAGYFDLWP 141
             D G G   Y+D  P
Sbjct: 107 GGDQGYGSGRYYDSRP 122



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 24/84 (28%), Positives = 35/84 (41%), Gaps = 6/84 (7%)

Query: 903 RSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSG 962
           R DH G+       +G    A+G GR  +      G    YG G  Y+   G     +  
Sbjct: 78  RVDHAGKSA--RGTRGGGFGAHGRGRSYSRGGGDQG----YGSGRYYDSRPGGYGYGYGR 131

Query: 963 GRDSSIKSYGLSDRYGGGGHYEEY 986
            RD + ++ G  DRY GG + + Y
Sbjct: 132 SRDYNGRNQGGYDRYSGGNYRDNY 155



 Score = 35.0 bits (79), Expect = 0.38
 Identities = 35/111 (31%), Positives = 43/111 (38%), Gaps = 25/111 (22%)

Query: 592 EEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEY-RGRSLDANSGGRSPDAY 650
           E   GR +  +  G+S     GG         +G  GR   Y RG        GR  D+ 
Sbjct: 70  ESLDGRQIRVDHAGKSARGTRGGG--------FGAHGRGRSYSRGGGDQGYGSGRYYDSR 121

Query: 651 SGGHDSSGQSNCYGGG-GRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSN 700
            GG         YG G GR  +Y GR    N GG   D YSGG+   +  N
Sbjct: 122 PGG---------YGYGYGRSRDYNGR----NQGGY--DRYSGGNYRDNYDN 157



 Score = 34.3 bits (77), Expect = 0.64
 Identities = 28/88 (31%), Positives = 30/88 (34%), Gaps = 22/88 (25%)

Query: 865 RGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAY 924
           RG     H RGRS            YSRG        G    YG G  Y+   G     Y
Sbjct: 90  RGGGFGAHGRGRS------------YSRG--------GGDQGYGSGRYYDSRPGGYGYGY 129

Query: 925 GGGRGLNSSNNSHGRSHRYGGGGRYEEY 952
           G  R  N  N   G   RY GG   + Y
Sbjct: 130 GRSRDYNGRN--QGGYDRYSGGNYRDNY 155



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 24/87 (27%), Positives = 34/87 (39%), Gaps = 3/87 (3%)

Query: 780 EEYRGRSLDANSGGRSPNAY-SGGHNSSSRNDP-CRGGGRYEENRGHSLDANSGGHSPNA 837
           E   GR +  +  G+S      GG  +  R     RGGG      G   D+  GG+    
Sbjct: 70  ESLDGRQIRVDHAGKSARGTRGGGFGAHGRGRSYSRGGGDQGYGSGRYYDSRPGGYG-YG 128

Query: 838 YSGGRDSSSNSYDRSHRYGGGGHYEEY 864
           Y   RD +  +     RY GG + + Y
Sbjct: 129 YGRSRDYNGRNQGGYDRYSGGNYRDNY 155



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 22/65 (33%), Positives = 26/65 (40%), Gaps = 2/65 (3%)

Query: 953  RGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYS 1012
            RG    AH  GR  S    G    YG G +Y+   G     Y    D +  + G  DRYS
Sbjct: 90   RGGGFGAHGRGR--SYSRGGGDQGYGSGRYYDSRPGGYGYGYGRSRDYNGRNQGGYDRYS 147

Query: 1013 RGRDR 1017
             G  R
Sbjct: 148  GGNYR 152



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 26/85 (30%), Positives = 34/85 (40%), Gaps = 14/85 (16%)

Query: 360 DHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEY-RGRSPDAHSGGRNSSSNSYGQSHHYG 418
           DH+ K+  G R      + R   Y   G  + Y  GR  D+  GG       YG+S  Y 
Sbjct: 80  DHAGKSARGTRGGGFGAHGRGRSYSRGGGDQGYGSGRYYDSRPGGYGYG---YGRSRDYN 136

Query: 419 G--EGRYEEYRGRSHEARSGGRSTD 441
           G  +G Y+ Y        SGG   D
Sbjct: 137 GRNQGGYDRY--------SGGNYRD 153


>gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens]
          Length = 589

 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 166/645 (25%), Positives = 223/645 (34%), Gaps = 108/645 (16%)

Query: 406  SSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCC 465
            S S SYGQS   GGE +     G       G  S      G++ D+  G           
Sbjct: 2    SDSGSYGQS---GGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYG----------- 47

Query: 466  GGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANS--G 523
                  + Y G S    S G S     GG++N   S  Y    +  + +  +++++   G
Sbjct: 48   ------QNYSGYS----SYGQSYSQSYGGYENQKQSS-YSQQPYNNQGQQQNMESSGSQG 96

Query: 524  GRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSN 583
            GR+P       S     YGQ   Y  +  Y+    S+D  S       Y   HDS SQ+ 
Sbjct: 97   GRAP-------SYDQPDYGQQDSYDQQSGYDQHQGSYDEQSN------YDQQHDSYSQNQ 143

Query: 584  RYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSG 643
            +      + +    S       R  + Y  G D+  +    GGG      RGR    +  
Sbjct: 144  Q----SYHSQRENYSHHTQDDRRDVSRY--GEDNRGYGGSQGGG------RGRG-GYDKD 190

Query: 644  GRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPD---AYSGGHDSSSQSN 700
            GR P   S G D  G  N +GG   Y    G   DA+S   + D    +  G      ++
Sbjct: 191  GRGPMTGSSGGDRGGFKN-FGGHRDY----GPRTDADSESDNSDNNTIFVQGLGEGVSTD 245

Query: 701  RYG------GGGRYEEYRGHSL-----DANSG---GRSPDTYSRGHDSSSQSDHYGGG-- 744
            + G      G  +  +  G  +     D ++G   G +  ++     + +  D + G   
Sbjct: 246  QVGEFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDGKEF 305

Query: 745  -GRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGR-SPNAYSGG 802
             G  +  + + R P+   GG     R  R G  GR   ++GR  D  SG    PN   G 
Sbjct: 306  HGNIIKVSFATRRPEFMRGGGSGGGRRGRGGYRGR-GGFQGRGGDPKSGDWVCPNPSCGN 364

Query: 803  HNSSSRNDPCR--GGGRYEENRGHSLDANS---GGHSPNAYSGGRDSSSNSYDRSHRYGG 857
             N + RN  C      R E++R    D      GG       GGR      Y      GG
Sbjct: 365  MNFARRNS-CNQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGG 423

Query: 858  -GGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEY 916
             GG      G S D    G   D   G +  +            YG     G GG    Y
Sbjct: 424  YGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGY 483

Query: 917  QGRSPNAYGGGRGLNSSNNSHGRSHRYGG--GGRYEEYRGPSPDAHSGGRDSSIKSYGLS 974
             G     YGG RG             YGG  GG   +  G   D    G D S   YG  
Sbjct: 484  GGDRGGGYGGDRG------------GYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYG-G 530

Query: 975  DRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVG 1019
            DR GG G    Y G     Y G  DRS   YG       G DR G
Sbjct: 531  DRGGGSG----YGGDRSGGYGG--DRSGGGYGGDRGGGYGGDRGG 569



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 149/625 (23%), Positives = 219/625 (35%), Gaps = 82/625 (13%)

Query: 360 DHSPKAYSGGRSSSSNGYSR--SDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHH- 416
           D      SGG   S + Y    S  YG+        G++ D+  G   S  +SYGQS+  
Sbjct: 3   DSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSYSQ 62

Query: 417 -YGGEGRYEEYRGRSHEAR-------------SGGRSTDAHSRGRSDDAYSGGHDSSSWS 462
            YGG   YE  +  S+  +             SG +   A S  + D      +D  S  
Sbjct: 63  SYGG---YENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQSGY 119

Query: 463 DCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSW---SDRYGVGGHYEENRGHSLD 519
           D     G Y+E        +S   + ++Y    +N S     DR  V  + E+NRG+   
Sbjct: 120 D--QHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYG-G 176

Query: 520 ANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSS 579
           +  GGR      GG+             G  G ++  G  H  +     AD+ S   D++
Sbjct: 177 SQGGGRG----RGGYDKDGRGPMTGSSGGDRGGFKNFG-GHRDYGPRTDADSESDNSDNN 231

Query: 580 SQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLD 639
           +   +  G G   +  G       G    N  +G    + ++ +  G  + E       D
Sbjct: 232 TIFVQGLGEGVSTDQVGEFFK-QIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFD-D 289

Query: 640 ANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQS 699
             S   + D + G                 +E+ G ++  +   R P+   GG     + 
Sbjct: 290 PPSAKAAIDWFDG-----------------KEFHGNIIKVSFATRRPEFMRGGGSGGGRR 332

Query: 700 NRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDA 759
            R G  GR   ++G   D  SG       S G+ + ++ +       S +  +  R  D+
Sbjct: 333 GRGGYRGR-GGFQGRGGDPKSGDWVCPNPSCGNMNFARRN-------SCNQCNEPRPEDS 384

Query: 760 YSGGHDSSSRSHRYGG-------GGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRN--- 809
              G D   R   YGG       GGR  +  G   D + GG   +  SGG  S  R+   
Sbjct: 385 RPSGGDFRGRG--YGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGG 442

Query: 810 -DPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSY--DRSHRYGG--GGHYEEY 864
               R GG Y  +RG     + GG       GG       Y  DR   YGG  GG+  + 
Sbjct: 443 YGGDRSGGGYGGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDR 502

Query: 865 RGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAY 924
            G   D    G     + GD     Y   R    + YG     G GG       RS   Y
Sbjct: 503 GGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGG-GSGYGGDRSGGYGG------DRSGGGY 555

Query: 925 GGGRGLNSSNNSHGRSHRYGGGGRY 949
           GG RG     +  G   + GG   Y
Sbjct: 556 GGDRGGGYGGDRGGYGGKMGGRNDY 580



 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 157/605 (25%), Positives = 221/605 (36%), Gaps = 120/605 (19%)

Query: 259 YSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSY-----REPLKSYGGPCGA 313
           Y + Y G+SS        G      Y G +++     S+  Y     ++ ++S G   G 
Sbjct: 46  YGQNYSGYSSY-------GQSYSQSYGGYENQKQSSYSQQPYNNQGQQQNMESSGSQGGR 98

Query: 314 APVWGTPP-----SYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSG 368
           AP +  P      SY     Y+++QG+  +  +  +          D+YS++   ++Y  
Sbjct: 99  APSYDQPDYGQQDSYDQQSGYDQHQGSYDEQSNYDQQH--------DSYSQNQ--QSYHS 148

Query: 369 GRSSSSNGYSRSDR-----YGEE-----GCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYG 418
            R + S+ +++ DR     YGE+     G     RGR       GR   + S G     G
Sbjct: 149 QRENYSH-HTQDDRRDVSRYGEDNRGYGGSQGGGRGRG-GYDKDGRGPMTGSSG-----G 201

Query: 419 GEGRYEEYRGRSHEARSGGRSTDAHSRGRSDD---AYSGGHDSSSWSDCCG------GGG 469
             G ++ + G     R  G  TDA S   + D    +  G      +D  G      G  
Sbjct: 202 DRGGFKNFGGH----RDYGPRTDADSESDNSDNNTIFVQGLGEGVSTDQVGEFFKQIGII 257

Query: 470 RYEEYQGRSL-----DANSGGCSPEAYSGGHDNSS------WSDRYGVGGHYEENRGHSL 518
           +  +  G+ +     D ++G    EA     D  S      W D        +E  G+ +
Sbjct: 258 KTNKKTGKPMINLYTDKDTGKPKGEATVSFDDPPSAKAAIDWFDG-------KEFHGNII 310

Query: 519 DANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDS 578
             +   R P+   GG S      G+  R G  GR  ++GR  D  SG       S G+ +
Sbjct: 311 KVSFATRRPEFMRGGGSGG----GRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMN 366

Query: 579 SSQSNRYGGGGCYEEYRGRSLDAN-SGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRS 637
            ++ N      C +    R  D+  SGG       GG          G GGR  +  G  
Sbjct: 367 FARRN-----SCNQCNEPRPEDSRPSGGDFRGRGYGGERGYR-----GRGGRGGDRGGYG 416

Query: 638 LDANSGGRSPDAYSGGHDSSGQSNC-YGG---GGRYEEYRGRLLDANSGGRSPDAYSGGH 693
            D + GG   D  SGG  S  +S   YGG   GG Y   RG       GG   D   GG 
Sbjct: 417 GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSGGGYGGDRG-------GGYGGDR--GGG 467

Query: 694 DSSSQSNRYGGG-GRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGG--GGRSLDA 750
               +   YGG  G Y   RG     + GG   D    G D       YGG  GG   D 
Sbjct: 468 YGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGG----YGGDRGGYGGDR 523

Query: 751 NSSGRLPDAYSGGHDSSSRSHRYGG---GGRYEEYRGRSLDANSGGRSPNAYSG--GHNS 805
           +  G   D   G      RS  YGG   GG Y   RG     + GG     Y G  G  +
Sbjct: 524 SRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGG-----YGGKMGGRN 578

Query: 806 SSRND 810
             RND
Sbjct: 579 DYRND 583



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 83/318 (26%), Positives = 102/318 (32%), Gaps = 60/318 (18%)

Query: 275 LRGDGNQNGYRGRDHEYTDHPSKGSYREP--LKSYGGPCGAAPVWGTPPSYGGGCRYEEY 332
           +RG G+  G RGR          G YR     +  GG   +   W  P    G   +   
Sbjct: 322 MRGGGSGGGRRGR----------GGYRGRGGFQGRGGDPKSGD-WVCPNPSCGNMNFA-- 368

Query: 333 QGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEY 392
           + NS + C+E R  ++ P                SGG      GY      GE G    Y
Sbjct: 369 RRNSCNQCNEPRPEDSRP----------------SGG-DFRGRGYG-----GERG----Y 402

Query: 393 RGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAY 452
           RGR      GGR      YG     GG G      G      SG RS   +   RS   Y
Sbjct: 403 RGR------GGRGGDRGGYGGDRSGGGYGGDRSSGG----GYSGDRSGGGYGGDRSGGGY 452

Query: 453 SGGHDSSSWSDCCGG-----GGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWS-DRYGV 506
            G        D  GG     GG Y   +G       GG   +    G D   +  DR G 
Sbjct: 453 GGDRGGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGY 512

Query: 507 GGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGG 566
           GG   +  G+  D + GG   D   G       S G      G G    RG  +    GG
Sbjct: 513 GG---DRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGG 569

Query: 567 CSADAYSGGHDSSSQSNR 584
                       + Q NR
Sbjct: 570 YGGKMGGRNDYRNDQRNR 587



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 113/430 (26%), Positives = 138/430 (32%), Gaps = 86/430 (20%)

Query: 10  LFIGGLN--LKTDEKALKAEFGKYGHIIK---------VFLMKDRKTNKSRGFAFVTFES 58
           +F+ GL   + TD+     EF K   IIK         + L  D+ T K +G A V+F+ 
Sbjct: 233 IFVQGLGEGVSTDQVG---EFFKQIGIIKTNKKTGKPMINLYTDKDTGKPKGEATVSFDD 289

Query: 59  PADAKAAARDMNGKYLDGKAIMVA-QTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSS 117
           P  AKAA    +GK   G  I V+  T +P F          G G R R  +R RGG   
Sbjct: 290 PPSAKAAIDWFDGKEFHGNIIKVSFATRRPEFMRG----GGSGGGRRGRGGYRGRGG--- 342

Query: 118 PQRPPSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCG 177
                 QGR  D +    +    P    M   R         P  + + PS      G  
Sbjct: 343 -----FQGRGGDPKS-GDWVCPNPSCGNMNFARRNSCNQCNEPRPEDSRPS------GGD 390

Query: 178 MRGKAPTVSGQDGYSGLQPRRWAGPPHKRAVPRSSLARIGGSGMPGKAPAVWGQDGYSGP 237
            RG+     G+ GY G   R   G        RS      G G  G   +     GYSG 
Sbjct: 391 FRGRG--YGGERGYRGRGGR--GGDRGGYGGDRS------GGGYGGDRSS---GGGYSGD 437

Query: 238 RVREPLPPCRDPGDFVPALRDYSRRYYGHSSVPDYRPLRGDGNQNGYRGRDHEYTDHPSK 297
           R        R  G             YG      Y   RG G   G RG           
Sbjct: 438 RSGGGYGGDRSGGG------------YGGDRGGGYGGDRG-GGYGGDRG----------- 473

Query: 298 GSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAY 357
           G Y      YGG  G     G    YGG     +  G   D    G             Y
Sbjct: 474 GGYGGDRGGYGGDRGGG-YGGDRGGYGG-----DRGGYGGDRGGYGGDR--------GGY 519

Query: 358 SRDHSPKAYSGGRSSSSN-GYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHH 416
             D S   Y G R   S  G  RS  YG +     Y G     + G R       G  + 
Sbjct: 520 GGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMGGRND 579

Query: 417 YGGEGRYEEY 426
           Y  + R   Y
Sbjct: 580 YRNDQRNRPY 589



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 76/290 (26%), Positives = 94/290 (32%), Gaps = 46/290 (15%)

Query: 207 AVPRSSLARIGGSGMPGKAPAVW-GQDGYSG----PRVREPLPPCRDPGDFVPALRDYSR 261
           A  R    R GGSG   +    + G+ G+ G    P+  + + P    G+   A R+ S 
Sbjct: 315 ATRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRN-SC 373

Query: 262 RYYGHSSVPDYRPLRGD------GNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAP 315
                    D RP  GD      G + GYRGR     D    G  R    S GG      
Sbjct: 374 NQCNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDR----SGGG------ 423

Query: 316 VWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSN 375
            +G   S GGG     Y G+       G  S          Y  D     Y G R     
Sbjct: 424 -YGGDRSSGGG-----YSGDRSGGGYGGDRSGG-------GYGGDRGG-GYGGDRGGGYG 469

Query: 376 GYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARS 435
           G       G+ G Y   RG       GG       YG     G  G Y   RG       
Sbjct: 470 GDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYG-----GDRGGYGGDRG----GYG 520

Query: 436 GGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGG 485
           G RS   +   R   +  GG  S  +     GGG Y   +G     + GG
Sbjct: 521 GDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGG-YGGDRGGGYGGDRGG 569



 Score = 30.4 bits (67), Expect = 9.3
 Identities = 31/140 (22%), Positives = 49/140 (35%), Gaps = 22/140 (15%)

Query: 923  AYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRG--PSPDAHSGGRDSSIKSYGLSDRYGGG 980
            +YG   G   S +++G     G G   + Y G   + D+  G   S   SYG S     G
Sbjct: 6    SYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSYSQSYG 65

Query: 981  GHYEEYQGSLPDAYSGDHDRSSN-----------------SYGRSDRYSRGRDRVGRPDR 1023
            G+  + Q S       +  +  N                  YG+ D Y +   + G    
Sbjct: 66   GYENQKQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQ---QSGYDQH 122

Query: 1024 GLPLPMETGSPPLHDSYSRS 1043
                  ++     HDSYS++
Sbjct: 123  QGSYDEQSNYDQQHDSYSQN 142


>gi|4502847 cold inducible RNA binding protein [Homo sapiens]
          Length = 172

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 58/127 (45%), Positives = 74/127 (58%), Gaps = 8/127 (6%)

Query: 9   KLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADAKAAARD 68
           KLF+GGL+  T+E++L+  F KYG I +V ++KDR+T +SRGF FVTFE+  DAK A   
Sbjct: 7   KLFVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMA 66

Query: 69  MNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQRPPSQGRPD 128
           MNGK +DG+ I V Q  K +   SR      GS     F    RG G    R  S+G  D
Sbjct: 67  MNGKSVDGRQIRVDQAGKSSDNRSRGY--RGGSAGGRGFFRGGRGRG----RGFSRGGGD 120

Query: 129 DGRGYAG 135
             RGY G
Sbjct: 121 --RGYGG 125



 Score = 37.7 bits (86), Expect = 0.058
 Identities = 30/93 (32%), Positives = 40/93 (43%), Gaps = 8/93 (8%)

Query: 713 GHSLDANSGGRSPDTYSRGHDSSSQSDH---YGGGGRSLDANSSGRLPDAYSGGHDSSSR 769
           G  +  +  G+S D  SRG+   S        GG GR    +  G   D   GG+   SR
Sbjct: 74  GRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGG--DRGYGGNRFESR 131

Query: 770 SHRYGGGGRYEEYRGRS---LDANSGGRSPNAY 799
           S  YGG   Y   R +S    D +SGG   ++Y
Sbjct: 132 SGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSY 164



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 31/100 (31%), Positives = 42/100 (42%), Gaps = 12/100 (12%)

Query: 515 GHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSG 574
           G  +  +  G+S D  S G+   S   G+    GG GR    GR      G    D   G
Sbjct: 74  GRQIRVDQAGKSSDNRSRGYRGGSAG-GRGFFRGGRGR----GRGFSRGGG----DRGYG 124

Query: 575 GHDSSSQSNRYGGGGCYEEYRGRS---LDANSGGRSPNAY 611
           G+   S+S  YGG   Y   R +S    D +SGG   ++Y
Sbjct: 125 GNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSY 164



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 36/125 (28%), Positives = 49/125 (39%), Gaps = 27/125 (21%)

Query: 596 GRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHD 655
           G+S+D    GR       G  S + S  Y GG             ++GGR    + GG  
Sbjct: 69  GKSVD----GRQIRVDQAGKSSDNRSRGYRGG-------------SAGGRG--FFRGGR- 108

Query: 656 SSGQSNCYGGGGRYEEYRGRLLDANSGGR--SPDAYSGGHDSSSQSNRYGGGG---RYEE 710
             G+   +  GG    Y G   ++ SGG   S D YS    S   S+R  GG     Y+ 
Sbjct: 109 --GRGRGFSRGGGDRGYGGNRFESRSGGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDS 166

Query: 711 YRGHS 715
           Y  H+
Sbjct: 167 YATHN 171



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 30/92 (32%), Positives = 35/92 (38%), Gaps = 15/92 (16%)

Query: 866 GRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGR----SP 921
           G+S D  SRG          Y    + GR  F    GR   + RGG    Y G       
Sbjct: 83  GKSSDNRSRG----------YRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFESRS 132

Query: 922 NAYGGGRGLNSS-NNSHGRSHRYGGGGRYEEY 952
             YGG R   SS + S G S R  GG   + Y
Sbjct: 133 GGYGGSRDYYSSRSQSGGYSDRSSGGSYRDSY 164



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 35/114 (30%), Positives = 46/114 (40%), Gaps = 20/114 (17%)

Query: 428 GRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCS 487
           GR       G+S+D  SRG     Y GG          GG G +   +GR    + GG  
Sbjct: 74  GRQIRVDQAGKSSDNRSRG-----YRGGS--------AGGRGFFRGGRGRGRGFSRGG-G 119

Query: 488 PEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSY 541
              Y GG+   S S  YG    Y  +R     + SGG S  +  G +  S +SY
Sbjct: 120 DRGY-GGNRFESRSGGYGGSRDYYSSR-----SQSGGYSDRSSGGSYRDSYDSY 167



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 31/105 (29%), Positives = 45/105 (42%), Gaps = 11/105 (10%)

Query: 745 GRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHN 804
           GR +  + +G+  D  S G+   S     GG G +   RGR    + GG     Y GG+ 
Sbjct: 74  GRQIRVDQAGKSSDNRSRGYRGGSA----GGRGFFRGGRGRGRGFSRGG-GDRGY-GGNR 127

Query: 805 SSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSY 849
             SR+    G   Y  +R     + SGG+S  +  G    S +SY
Sbjct: 128 FESRSGGYGGSRDYYSSR-----SQSGGYSDRSSGGSYRDSYDSY 167



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 31/107 (28%), Positives = 41/107 (38%), Gaps = 16/107 (14%)

Query: 784 GRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRD 843
           GR +  +  G+S +  S G+   S      G G +   RG     + GG     Y G R 
Sbjct: 74  GRQIRVDQAGKSSDNRSRGYRGGSAG----GRGFFRGGRGRGRGFSRGG-GDRGYGGNRF 128

Query: 844 SSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAY 890
            S     RS  YGG   Y   R +S      G   D  SG  Y ++Y
Sbjct: 129 ES-----RSGGYGGSRDYYSSRSQS------GGYSDRSSGGSYRDSY 164



 Score = 33.9 bits (76), Expect = 0.84
 Identities = 31/102 (30%), Positives = 38/102 (37%), Gaps = 22/102 (21%)

Query: 373 SSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHE 432
           SS+  SR            YRG S    +GGR       G+   +   G    Y G   E
Sbjct: 85  SSDNRSRG-----------YRGGS----AGGRGFFRGGRGRGRGFSRGGGDRGYGGNRFE 129

Query: 433 ARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY 474
           +RSGG        G S D YS    S  +SD   GG   + Y
Sbjct: 130 SRSGG-------YGGSRDYYSSRSQSGGYSDRSSGGSYRDSY 164



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 31/90 (34%), Positives = 39/90 (43%), Gaps = 18/90 (20%)

Query: 904 SDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGG 963
           SD+  RG     Y+G S     GGRG        GR   +  GG    Y G   ++ SGG
Sbjct: 86  SDNRSRG-----YRGGS----AGGRGFFRGGRGRGRG--FSRGGGDRGYGGNRFESRSGG 134

Query: 964 ----RD---SSIKSYGLSDRYGGGGHYEEY 986
               RD   S  +S G SDR  GG + + Y
Sbjct: 135 YGGSRDYYSSRSQSGGYSDRSSGGSYRDSY 164



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 31/109 (28%), Positives = 40/109 (36%), Gaps = 18/109 (16%)

Query: 674 GRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHD 733
           GR +  +  G+S D  S G+   S     GG G +   RG     + GG   D    G+ 
Sbjct: 74  GRQIRVDQAGKSSDNRSRGYRGGSA----GGRGFFRGGRGRGRGFSRGGG--DRGYGGNR 127

Query: 734 SSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEY 782
             S+S  YGG              D YS    S   S R  GG   + Y
Sbjct: 128 FESRSGGYGGSR------------DYYSSRSQSGGYSDRSSGGSYRDSY 164


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 151/695 (21%), Positives = 240/695 (34%), Gaps = 68/695 (9%)

Query: 322  SYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSD 381
            S  G  + +    +S D+ +   SS++      D+ S   S  + S    SS +  S S 
Sbjct: 540  SDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS 599

Query: 382  RYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTD 441
               +     +    S D+     + S +S  +S     + + +     S ++     S+D
Sbjct: 600  NSSDSSDSSD-SSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSD 658

Query: 442  AHSRGRSDDAY--SGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSS 499
            + +   S D+   S   DSSS SD        +     S  +NS   S  + S   D+S 
Sbjct: 659  SSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS----SDSSNSSESSDSSDSSDSDSSD 714

Query: 500  WSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRS 559
             SD          +  +S D++S   S  + S   S SS+S   S+             S
Sbjct: 715  SSD---------SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD-------S 758

Query: 560  HDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNA--YSGGHDS 617
             D+ +   S+D+ S   DSS  SN              S D+N    S ++   S   DS
Sbjct: 759  SDSSNSSDSSDS-SDSSDSSDSSN--------------SSDSNDSSNSSDSSDSSNSSDS 803

Query: 618  SSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLL 677
            S+ S         +     S D+++   S D+ S   DSS  S+   G            
Sbjct: 804  SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS-SNSSDSSDSSDSSDGS----------- 851

Query: 678  DANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQ 737
            D++S  RS  + S     SS S+              S D+N    S D+    + S S 
Sbjct: 852  DSDSSNRSDSSNSSDSSDSSDSSNSSDS-------SDSSDSNESSNSSDSSDSSNSSDSD 904

Query: 738  SDHYGGGGRSLD-ANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSP 796
            S        S D +NSS     + S  + +SS S          +    S  +NS   S 
Sbjct: 905  SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964

Query: 797  NAYSGGHNSSSRNDPCRGGGRYE--ENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHR 854
            ++ S   NSS  +D        +  ++   S  ++S   S ++ S     SSNS D S+ 
Sbjct: 965  SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024

Query: 855  YGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYE 914
                   +     S  + S   S  + S D    + S      S+S   SD        +
Sbjct: 1025 SDSSNSSDS----SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1080

Query: 915  EYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLS 974
              +    +        + S++S   S         +     +    S   DSS  S   S
Sbjct: 1081 SSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD--S 1138

Query: 975  DRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYGRSD 1009
                      E   S   + S D   SS+S   SD
Sbjct: 1139 SNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD 1173



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 134/635 (21%), Positives = 210/635 (33%), Gaps = 29/635 (4%)

Query: 335  NSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRG 394
            +S D+     SSE+       + S D S    S    SS++  S SD        +    
Sbjct: 688  DSSDSSDSSNSSES-------SDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740

Query: 395  RSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSG 454
                  S   NSS +S         +         S ++ +   S D+ +   S D+ S 
Sbjct: 741  SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDS-SN 799

Query: 455  GHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENR 514
              DSS+ SD        +     S D+++   S ++ S   D+S  SD          NR
Sbjct: 800  SSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS-SNSSDSSDSSDSSDGSDSDSSNR 858

Query: 515  GHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYG--GEGRYEYRGRSHDAHSGGCSADAY 572
              S +++    S D+ +   SS S+   +S       +        S D+ +   S+D+ 
Sbjct: 859  SDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDS- 917

Query: 573  SGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEE 632
            S   DSS  SN        +         +S   + +  S   DSS+ S           
Sbjct: 918  SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977

Query: 633  YRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGG 692
                S D++    S D+ S   DSS  S+        +        +NS   S  + S  
Sbjct: 978  DSSNSSDSSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDS-------SNSSDSSNSSDSSN 1029

Query: 693  HDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANS 752
               SS S+         +    S  +NS   S  + S     SS S        S D++ 
Sbjct: 1030 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSD 1089

Query: 753  SGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPC 812
            S    D+ S   DSS  S         +     S  +NS   S ++ S   + SS +   
Sbjct: 1090 SSNSSDS-SDSSDSSDSSDSSDSSDSSDS----SDSSNSSDSSDSSDSSDSSDSSNSSDS 1144

Query: 813  RGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTH 872
                   ++   S  ++S   S ++ S     SSNS D S          +    S  + 
Sbjct: 1145 SDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSSDSSD 1203

Query: 873  SRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNS 932
            S   S  + S D    + S      S+S   SD        +       +         S
Sbjct: 1204 SSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTS 1263

Query: 933  SNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSS 967
             +N    S    G G      G   D+ S G DS+
Sbjct: 1264 DSNDESDSQSKSGNG---NNNGSDSDSDSEGSDSN 1295



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 115/562 (20%), Positives = 183/562 (32%), Gaps = 24/562 (4%)

Query: 335  NSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRG 394
            NS D+     SS +      D+     S  +     SS SN  S S    +     +   
Sbjct: 751  NSSDSSDSSDSSNS-----SDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSN 805

Query: 395  RSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSG 454
             S  + S   + S +S         +         S ++      +D+ S  RSD + S 
Sbjct: 806  SSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSS 865

Query: 455  ----GHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHY 510
                  DSS+ SD        E     S D++    S ++ S    NSS S         
Sbjct: 866  DSSDSSDSSNSSDSSDSSDSNES--SNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDS 923

Query: 511  EENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYR-GRSHDAHSGGCSA 569
             E+   S ++NS   S  + S   S SSNS   S+        +     S D+     S+
Sbjct: 924  SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983

Query: 570  DAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGR 629
            D+      S S  +              S D+++   S N+    + S S          
Sbjct: 984  DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043

Query: 630  YEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAY 689
                   S D+++   S D+ S   DSS  S+        E       D+++   S D+ 
Sbjct: 1044 DSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSSDSSDSSESSDSS--DSSNSSDSSDSS 1100

Query: 690  SGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDS--SSQSDHYGGGGRS 747
                 S S  +              S D++    S D+ S   DS  SS+S        S
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS-SNSSDSSDSSESSDSSDSSDS 1159

Query: 748  LDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSS 807
             D++ S    D+      S+S                 S D++    S ++     +S S
Sbjct: 1160 SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1219

Query: 808  RNDPCRGGGRYEENRGHSLDANSGGHSPNA-----YSGGRDSSSNSYDRSHRYGGGGHYE 862
             +               S D++    S N+      S   DS+S+S D S      G+  
Sbjct: 1220 SDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGN 1279

Query: 863  EYRGRSHDTHSRGRSPDAHSGD 884
               G   D+ S G   +  + D
Sbjct: 1280 N-NGSDSDSDSEGSDSNHSTSD 1300



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 142/685 (20%), Positives = 241/685 (35%), Gaps = 92/685 (13%)

Query: 341  SEGRSSEALPVVLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRY----GEEGCYEEYRGRS 396
            +EG +SE  P +      R+ + +A     +    G   SD      G +   +E  G  
Sbjct: 206  NEGNTSEITPQINS---KRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDD 262

Query: 397  PDAHSG-GRNSSSNSYGQS-HHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSG 454
             D  +G G++SS+NS GQ    +G E  ++   G++ +++      D   +    +   G
Sbjct: 263  EDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKE---YYDPEGKEDPHNEVDG 319

Query: 455  GHDSSSWSDCCG-----GGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGH 509
               S S  +  G     G  R E+ Q  +          E+    +  +  S+ + VG  
Sbjct: 320  DKTSKSEENSAGIPEDNGSQRIEDTQKLN--------HRESKRVENRITKESETHAVGK- 370

Query: 510  YEENRGHSLDA-NSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCS 568
              +++G  +   +SG R+     G  +      GQ     G+G  + +G   +    G  
Sbjct: 371  -SQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQK 429

Query: 569  ADAYSG-GHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGG 627
            ++  +  GH ++   +   G   Y+ +  +S+  +    S  + +G  D++S S      
Sbjct: 430  SEPGNKVGHSNTGSDSNSDGYDSYD-FDDKSMQGDDPNSSDES-NGNDDANSES------ 481

Query: 628  GRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPD 687
                       D NS  R   +Y+                          D  +G  S  
Sbjct: 482  -----------DNNSSSRGDASYNSDESK---------------------DNGNGSDSKG 509

Query: 688  AYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSG-GRSPDTYSRGHDSSSQSDHYGGGGR 746
            A     DS+S +N     G        +  ++SG G+S  + S   DSS+ SD       
Sbjct: 510  AEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSD--SSDSS 567

Query: 747  SLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSS 806
              D++ S    D+ S   DSS  S               S D++    S ++     +S 
Sbjct: 568  DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDS------SNSSDSSDSSDSSDSSDSSDSSD 621

Query: 807  SRNDPCR--GGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEY 864
            S++D  +        +++  S D+NS   S N+ S    +SSNS D S            
Sbjct: 622  SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD----- 676

Query: 865  RGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAY 924
               S D+ +   S D+    + +E+      S S+S   SD         +    S N+ 
Sbjct: 677  SSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSD----SSNSS 732

Query: 925  GGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYE 984
                  NSS++S                   S D+ S   DSS  S   S          
Sbjct: 733  DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS-SDSSDSSDSSD--SSNSSDSNDSS 789

Query: 985  EYQGSLPDAYSGDHDRSSNSYGRSD 1009
                S   + S D   SS+S   SD
Sbjct: 790  NSSDSSDSSNSSDSSNSSDSSDSSD 814


>gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma)
            [Homo sapiens]
          Length = 526

 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 141/555 (25%), Positives = 193/555 (34%), Gaps = 88/555 (15%)

Query: 505  GVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHS 564
            G G   + ++ +   + SG       SG   SS +SYGQS   G      Y  +S     
Sbjct: 22   GQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTG------YGTQSTPQGY 75

Query: 565  GGCSADAYSGGHDSSSQS-NRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHR 623
            G       +GG+ SS  S + YG    Y  Y  +         +P++ SG + SSS S  
Sbjct: 76   GS------TGGYGSSQSSQSSYGQQSSYPGYGQQP--------APSSTSGSYGSSSQSSS 121

Query: 624  YGGGGRYEEYRGRSLDANSGGRSPD-AYSGGHDSSGQSNCYG---GGGRYEEYRGRLLDA 679
            YG                SG  S   +Y G   S GQ   Y    G G+  +Y      +
Sbjct: 122  YG-------------QPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNS---SS 165

Query: 680  NSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSD 739
              GG      + G D SS S+  G GG Y          + G    D   RG   S    
Sbjct: 166  GGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGG 225

Query: 740  HYGGGGRSLDANSSGRLPDAYS---GGHDSSSRSHRYG----GGGRYEEYRGRSLDANSG 792
              GGGG   + +S G  P       GG      S R G    GG R +  R  S   NS 
Sbjct: 226  --GGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSD 283

Query: 793  GRSPNAYSGGHNSS--SRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGG-----RDSS 845
              +      G N +  S  D  +  G  + N+       +G    N Y+       +  +
Sbjct: 284  NNTIFVQGLGENVTIESVADYFKQIGIIKTNK------KTGQPMINLYTDRETGKLKGEA 337

Query: 846  SNSYDRSHRYGGGGHY---EEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYG 902
            + S+D          +   +E+ G         R  D + G        RG        G
Sbjct: 338  TVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGG----GNGRGGRGRGGPMG 393

Query: 903  RSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSN-----NSHGRSHRYGGGGRYEEYRGPSP 957
            R   YG GG     +G  P+  GGG G   +      N    +  +       + + P P
Sbjct: 394  RGG-YGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKP 452

Query: 958  DAHSGGRDSSIK--SYGLSDRYGGGGHYEE--YQGSLPD-----AYSGDHDRSSNSYGRS 1008
            D   GG   S    +YG  DR GG G Y+   Y+G   D        G  DR     G+ 
Sbjct: 453  DGPGGGPGGSHMGGNYG-DDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKM 511

Query: 1009 DRYSRGRDRVGRPDR 1023
            D  SRG  R  R +R
Sbjct: 512  D--SRGEHRQDRRER 524



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 81/276 (29%), Positives = 114/276 (41%), Gaps = 35/276 (12%)

Query: 589 GCYEEYRGRSLDANS----GGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGG 644
           G Y    G+     S    G +S + YS   D+S +     G   Y  Y G+S +   G 
Sbjct: 15  GAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGY-----GQSSYSSY-GQSQNTGYGT 68

Query: 645 RS-PDAY--SGGHDSSGQS-NCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSN 700
           +S P  Y  +GG+ SS  S + YG    Y  Y  +         +P + SG + SSSQS+
Sbjct: 69  QSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQ--------PAPSSTSGSYGSSSQSS 120

Query: 701 RYGG--GGRYEEYRGHSLDANSGGRS-----PDTYSRG--HDSSSQSDHYGGGGRSLDAN 751
            YG    G Y +   +     S G+      P  Y +   ++SSS     GGGG +   +
Sbjct: 121 SYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQD 180

Query: 752 SSGRLPDAYS-GGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRND 810
            S       S GG+ +  +S   G GG  ++ RG      SGG       GG+N SS   
Sbjct: 181 QSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGG-GGGYNRSSGGY 239

Query: 811 PCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSS 846
             RG G     RG    ++ GG   N + G RD  S
Sbjct: 240 EPRGRGGGRGGRGGMGGSDRGGF--NKFGGPRDQGS 273



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 128/554 (23%), Positives = 190/554 (34%), Gaps = 78/554 (14%)

Query: 291 YTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALP 350
           Y   P +G  ++  + YG    +     T  S  G   Y  Y          G+S     
Sbjct: 17  YPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSY----------GQSQNT-- 64

Query: 351 VVLPDAYSRDHSPKAY--SGGRSSSSNGYSRSDRYGEEGCYEEYRGR-SPDAHSG--GRN 405
                 Y    +P+ Y  +GG  SS +  S    YG++  Y  Y  + +P + SG  G +
Sbjct: 65  -----GYGTQSTPQGYGSTGGYGSSQSSQSS---YGQQSSYPGYGQQPAPSSTSGSYGSS 116

Query: 406 SSSNSYGQSHHYGGEGRYEEYRGR--SHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSD 463
           S S+SYGQ    G   +   Y G+  S+  +        + +    ++ SGG        
Sbjct: 117 SQSSSYGQPQS-GSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGG---- 171

Query: 464 CCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGH-----SL 518
             GGGG Y + Q      +SGG S     GG+ N   S   G GG+ +++RG      S 
Sbjct: 172 --GGGGNYGQDQS---SMSSGGGS----GGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSG 222

Query: 519 DANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDS 578
               GG       GG++ SS  Y    R GG G     G S              G    
Sbjct: 223 GGGGGG------GGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHD 276

Query: 579 SSQSNRYGGGGCYEEYRGRSLDANS--------GGRSPNAYSGGHDSSSWSHRYGGGGRY 630
           S Q N       + +  G ++   S        G    N  +G    + ++ R    G+ 
Sbjct: 277 SEQDNS-DNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDR--ETGKL 333

Query: 631 EEYRGRSLDANSGGRSPDAYSGGHDSSG----------QSNCYGGGGRYEEYRGRLLDAN 680
           +     S D     ++   +  G + SG          +++   GGG     RGR     
Sbjct: 334 KGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG 393

Query: 681 SGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDH 740
            GG       GG      S   GGGG  ++  G     N    + +   R   +  ++  
Sbjct: 394 RGGYGGGGSGGGGRGGFPSG--GGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPK 451

Query: 741 YGG-GGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAY 799
             G GG    ++  G   D   GG     R    G GG    +RG     + GG  P   
Sbjct: 452 PDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKM 511

Query: 800 S--GGHNSSSRNDP 811
              G H    R  P
Sbjct: 512 DSRGEHRQDRRERP 525



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 135/548 (24%), Positives = 184/548 (33%), Gaps = 120/548 (21%)

Query: 358 SRDHSPKAYSG-GRSSSSNGYSRSD--RYGEE-----GCYEEYRGRSPDAHSGGRNSSSN 409
           S+ +  ++YSG  +S+ ++GY +S    YG+      G     +G       G   SS +
Sbjct: 30  SQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQS 89

Query: 410 SYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGG 469
           SYGQ   Y G   Y +    S  + S G S+ + S G+          S S+S     GG
Sbjct: 90  SYGQQSSYPG---YGQQPAPSSTSGSYGSSSQSSSYGQPQ--------SGSYSQQPSYGG 138

Query: 470 RYEEY-QGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGH--SLDANSGGRS 526
           + + Y Q +S +   G      Y+    +S      G GG+Y +++    S   + GG  
Sbjct: 139 QQQSYGQQQSYNPPQGYGQQNQYNS---SSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYG 195

Query: 527 PDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYG 586
               SGG    S  YGQ  R GG GR            GG      SGG          G
Sbjct: 196 NQDQSGG--GGSGGYGQQDR-GGRGR------------GG------SGG---------GG 225

Query: 587 GGGCYEEYRGRSLDANSGGRSPNAYS---GGHDSSSWSHRYG----GGGRYEEYRGRSLD 639
           GGG      G   + +SGG  P       GG      S R G    GG R +  R  S  
Sbjct: 226 GGG------GGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQ 279

Query: 640 ANSGGRSPDAYSGGHDSSGQS-------------NCYGGGGRYEEYRGRLLDANSGGRSP 686
            NS   +      G + + +S             N   G      Y     D  +G    
Sbjct: 280 DNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLY----TDRETGKLKG 335

Query: 687 DAYSGGHDSSS--------QSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQS 738
           +A     D  S            + G      +     D N GG +     RG       
Sbjct: 336 EATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGN-GRGGRGRGGPMGR 394

Query: 739 DHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNA 798
             YGGGG    +   GR      GG  S       GGGG  ++  G         + PN 
Sbjct: 395 GGYGGGG----SGGGGR------GGFPSG------GGGGGGQQRAG-------DWKCPNP 431

Query: 799 YSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGG 858
                N S RN+  +      +  G       G H    Y   R      YDR    G G
Sbjct: 432 TCENMNFSWRNECNQCKAPKPDGPG---GGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRG 488

Query: 859 GHYEEYRG 866
           G    +RG
Sbjct: 489 GDRGGFRG 496



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 81/312 (25%), Positives = 111/312 (35%), Gaps = 79/312 (25%)

Query: 752  SSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDP 811
            S G  P     G+   S S  YG     + Y G S   ++ G   ++YS    S      
Sbjct: 13   SYGAYPTQPGQGYSQQS-SQPYG----QQSYSGYSQSTDTSGYGQSSYSSYGQS------ 61

Query: 812  CRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDT 871
                    +N G+   +   G+      G   SS +SY +   Y G   Y +    S  +
Sbjct: 62   --------QNTGYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPG---YGQQPAPSSTS 110

Query: 872  HSRGRSPDAHS-GDHYTEAYSRGRDSFSN---SYGRSDHYGRGGCYEEYQGRSPNAYGGG 927
             S G S  + S G   + +YS+ + S+     SYG+   Y     Y +    + ++ GGG
Sbjct: 111  GSYGSSSQSSSYGQPQSGSYSQ-QPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGG 169

Query: 928  RGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQ 987
             G    N    +S    GGG             SGG       YG  D+ GGGG      
Sbjct: 170  GGGGGGNYGQDQSSMSSGGG-------------SGG------GYGNQDQSGGGG------ 204

Query: 988  GSLPDAYSGDHDRSSNSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSR-SGCR 1046
                          S  YG+ DR  RGR   G            G       Y+R SG  
Sbjct: 205  --------------SGGYGQQDRGGRGRGGSG-----------GGGGGGGGGYNRSSGGY 239

Query: 1047 VPRG-GGRQGGR 1057
             PRG GG +GGR
Sbjct: 240  EPRGRGGGRGGR 251



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 43/149 (28%), Positives = 60/149 (40%), Gaps = 15/149 (10%)

Query: 10  LFIGGLNLKTDEKALKAEFGKYGHIIK---------VFLMKDRKTNKSRGFAFVTFESPA 60
           +F+ GL      +++   F + G IIK         + L  DR+T K +G A V+F+ P 
Sbjct: 287 IFVQGLGENVTIESVADYFKQIG-IIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPP 345

Query: 61  DAKAAARDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRG--GGSSP 118
            AKAA    +GK   G  I V+   + A  +        G G R R     RG  GG   
Sbjct: 346 SAKAAIDWFDGKEFSGNPIKVSFATRRADFNR---GGGNGRGGRGRGGPMGRGGYGGGGS 402

Query: 119 QRPPSQGRPDDGRGYAGYFDLWPYRAPMP 147
                 G P  G G  G      ++ P P
Sbjct: 403 GGGGRGGFPSGGGGGGGQQRAGDWKCPNP 431


>gi|55956899 keratin 9 [Homo sapiens]
          Length = 623

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 61/179 (34%), Positives = 69/179 (38%), Gaps = 33/179 (18%)

Query: 492 SGGHDNSSWSDRYGVGGHY-EENRGHSLDANSGGRSPDTHSGGHSS---SSNSYGQSHRY 547
           S G        R G GG Y   +RG S  +  GG S   + GG  S   S  SYG     
Sbjct: 467 SSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGS 526

Query: 548 GGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRS 607
           GG     Y G S   HSGG      SGG  S      YGGG            + SGG S
Sbjct: 527 GGGSGGGYGGGSGGGHSGG------SGGGHSGGSGGNYGGG------------SGSGGGS 568

Query: 608 PNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGG 666
              Y GG  S   S    GGG           +  GG S  +Y GG ++SG    YGGG
Sbjct: 569 GGGYGGGSGSRGGSGGSHGGG-----------SGFGGESGGSYGGGEEASGSGGGYGGG 616



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 65/198 (32%), Positives = 76/198 (38%), Gaps = 42/198 (21%)

Query: 548 GGEGRYEYRGRSHDAHSG-GCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGR 606
           GG+  +E  G       G G S  +Y  G    S  + YGGGG    Y G S    S G 
Sbjct: 460 GGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGS-YGGGGSGGGYGGGS---GSRGG 515

Query: 607 SPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGG 666
           S  +Y GG  S        GGG    Y G S   +SGG      SGG  S G    YGGG
Sbjct: 516 SGGSYGGGSGS--------GGGSGGGYGGGSGGGHSGG------SGGGHSGGSGGNYGGG 561

Query: 667 GRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPD 726
                       + SGG S   Y GG  S   S    GGG           +  GG S  
Sbjct: 562 ------------SGSGGGSGGGYGGGSGSRGGSGGSHGGG-----------SGFGGESGG 598

Query: 727 TYSRGHDSSSQSDHYGGG 744
           +Y  G ++S     YGGG
Sbjct: 599 SYGGGEEASGSGGGYGGG 616



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 69/217 (31%), Positives = 75/217 (34%), Gaps = 55/217 (25%)

Query: 560 HDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSS 619
           H+   GG   D  S G        R G GG Y             GR     SGG     
Sbjct: 455 HNLLEGG-QEDFESSGAGKIGLGGRGGSGGSY-------------GRGSRGGSGGS---- 496

Query: 620 WSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDA 679
               YGGGG    Y G S    S G S  +Y GG  S G S    GGG            
Sbjct: 497 ----YGGGGSGGGYGGGS---GSRGGSGGSYGGGSGSGGGSGGGYGGG------------ 537

Query: 680 NSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSD 739
            SGG       GGH   S  N YGGG            + SGG S   Y  G  S   S 
Sbjct: 538 -SGGGHSGGSGGGHSGGSGGN-YGGG------------SGSGGGSGGGYGGGSGSRGGSG 583

Query: 740 HYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGG 776
              GGG      S G    +Y GG ++S     YGGG
Sbjct: 584 GSHGGGSGFGGESGG----SYGGGEEASGSGGGYGGG 616



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 56/177 (31%), Positives = 63/177 (35%), Gaps = 21/177 (11%)

Query: 683 GRSPDAYSGGHDSSSQSNRYGGGGRYEE-YRGHSLDANSGGRSPDTYSRGHDSSSQSDHY 741
           G   D  S G        R G GG Y    RG S  +  GG S   Y  G  S   S   
Sbjct: 460 GGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGS 519

Query: 742 GGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSG 801
            GGG      S G       GGH   S     GG G    Y G S    SGG S   Y G
Sbjct: 520 YGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSG--GNYGGGS---GSGGGSGGGYGG 574

Query: 802 GHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGG 858
           G  S   +    GGG           +  GG S  +Y GG ++S +       YGGG
Sbjct: 575 GSGSRGGSGGSHGGG-----------SGFGGESGGSYGGGEEASGS----GGGYGGG 616



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 59/172 (34%), Positives = 64/172 (37%), Gaps = 28/172 (16%)

Query: 532 GGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSN-RYGGGGC 590
           GG   S  SYG+  R G  G Y           GG S   Y GG  S   S   YGGG  
Sbjct: 476 GGRGGSGGSYGRGSRGGSGGSY----------GGGGSGGGYGGGSGSRGGSGGSYGGGSG 525

Query: 591 YEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGR--SPD 648
                G      SGG       GGH   S  + YGGG       G      SG R  S  
Sbjct: 526 SGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGN-YGGGSGSGGGSGGGYGGGSGSRGGSGG 584

Query: 649 AYSGGHDSSGQS-NCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQS 699
           ++ GG    G+S   YGGG   EE  G      SGG     Y GG   SS S
Sbjct: 585 SHGGGSGFGGESGGSYGGG---EEASG------SGG----GYGGGSGKSSHS 623



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 67/222 (30%), Positives = 81/222 (36%), Gaps = 64/222 (28%)

Query: 413 QSHHYGGEGRYEEYR-------GRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCC 465
           +++H   EG  E++        G      SGG S    SRG S  +Y GG          
Sbjct: 452 ETYHNLLEGGQEDFESSGAGKIGLGGRGGSGG-SYGRGSRGGSGGSYGGG---------- 500

Query: 466 GGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGR 525
           G GG Y    G      S G S  +Y GG  +       G GG Y            GG 
Sbjct: 501 GSGGGYGGGSG------SRGGSGGSYGGGSGSGG-----GSGGGY------------GGG 537

Query: 526 SPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRY 585
           S   HSGG S   +S G    YGG            + SGG S   Y GG  S   S   
Sbjct: 538 SGGGHSGG-SGGGHSGGSGGNYGG-----------GSGSGGGSGGGYGGGSGSRGGSGGS 585

Query: 586 GGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGG 627
            GGG           +  GG S  +Y GG ++S     YGGG
Sbjct: 586 HGGG-----------SGFGGESGGSYGGGEEASGSGGGYGGG 616



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 63/194 (32%), Positives = 73/194 (37%), Gaps = 52/194 (26%)

Query: 393 RGRSPDAHS-GGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDA 451
           RG S  ++  G R  S  SYG     GG G              GG    + SRG S  +
Sbjct: 478 RGGSGGSYGRGSRGGSGGSYGG----GGSG--------------GGYGGGSGSRGGSGGS 519

Query: 452 YSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYE 511
           Y GG  S        GGG    Y G S   +SGG       GGH         G GG+Y 
Sbjct: 520 YGGGSGS--------GGGSGGGYGGGSGGGHSGGS-----GGGHSG-------GSGGNYG 559

Query: 512 ENRGHSLDANSGGRSPDTHSGGHSS---SSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCS 568
              G      SGG S   + GG  S   S  S+G    +GGE    Y G    + SGG  
Sbjct: 560 GGSG------SGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGG-- 611

Query: 569 ADAYSGGHDSSSQS 582
              Y GG   SS S
Sbjct: 612 --GYGGGSGKSSHS 623



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 52/166 (31%), Positives = 60/166 (36%), Gaps = 21/166 (12%)

Query: 402 GGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSW 461
           GGR  S  SYG+    G  G Y            GG    + SRG S  +Y GG  S   
Sbjct: 476 GGRGGSGGSYGRGSRGGSGGSY------GGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGG 529

Query: 462 SDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDAN 521
           S    GGG    + G S   +SGG      SGG+         G GG Y    G      
Sbjct: 530 SGGGYGGGSGGGHSGGSGGGHSGG------SGGNYGGGSGSGGGSGGGYGGGSG------ 577

Query: 522 SGGRSPDTHSGGHS---SSSNSYGQSHRYGGEGRYEYRGRSHDAHS 564
           S G S  +H GG      S  SYG      G G     G    +HS
Sbjct: 578 SRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGKSSHS 623



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 60/171 (35%), Positives = 70/171 (40%), Gaps = 29/171 (16%)

Query: 840  GGRDSSSNSYDRSHR------YGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRG 893
            GGR  S  SY R  R      YGGGG    Y G S    SRG S  ++ G   +   S G
Sbjct: 476  GGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGS---GSRGGSGGSYGGGSGSGGGSGG 532

Query: 894  RDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYR 953
                 +  G S   G G     + G S   YGGG G     +  G    YGGG      R
Sbjct: 533  GYGGGSGGGHSGGSGGG-----HSGGSGGNYGGGSG-----SGGGSGGGYGGG---SGSR 579

Query: 954  GPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSSNS 1004
            G S  +H GG     +S G    YGGG   EE  GS    Y G   +SS+S
Sbjct: 580  GGSGGSHGGGSGFGGESGG---SYGGG---EEASGS-GGGYGGGSGKSSHS 623



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 68/201 (33%), Positives = 76/201 (37%), Gaps = 49/201 (24%)

Query: 735 SSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGR 794
           SS +   G GGR     S GR     SGG         YGGGG    Y G S    S G 
Sbjct: 467 SSGAGKIGLGGRGGSGGSYGRGSRGGSGGS--------YGGGGSGGGYGGGS---GSRGG 515

Query: 795 SPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNA---YSGGRDSSSNSYDR 851
           S  +Y GG  S   +    GGG      GHS   + GGHS  +   Y GG  S   S   
Sbjct: 516 SGGSYGGGSGSGGGSGGGYGGG---SGGGHS-GGSGGGHSGGSGGNYGGGSGSGGGS--- 568

Query: 852 SHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGG 911
              YGGG            + SRG S  +H G             F    G S  YG G 
Sbjct: 569 GGGYGGG------------SGSRGGSGGSHGGG----------SGFGGESGGS--YGGG- 603

Query: 912 CYEEYQGRSPNAYGGGRGLNS 932
             EE  G S   YGGG G +S
Sbjct: 604 --EEASG-SGGGYGGGSGKSS 621



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 55/165 (33%), Positives = 66/165 (40%), Gaps = 27/165 (16%)

Query: 695 SSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSG 754
           SSS  +R GGGG      G  L   SGG    +YSR   S       GGGG    ++SSG
Sbjct: 7   SSSYLSRSGGGG------GGGL--GSGGSIRSSYSRFSSSG------GGGGGGRFSSSSG 52

Query: 755 RLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRG 814
                Y GG   SSR    GGGG +    G     + GG S ++  GG    SR      
Sbjct: 53  -----YGGG---SSRVCGRGGGGSFGYSYG---GGSGGGFSASSLGGGFGGGSRGFGGAS 101

Query: 815 GGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGG 859
           GG Y  + G       GG S   + GG  S    +       GGG
Sbjct: 102 GGGYSSSGG--FGGGFGGGSGGGFGGGYGSGFGGFGGFGGGAGGG 144



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 46/153 (30%), Positives = 54/153 (35%), Gaps = 25/153 (16%)

Query: 368 GGRSSSSNGYSRSDRYGEEGCY------------EEYRGRSPDAHSGGRNSSSNSYGQSH 415
           GGR  S   Y R  R G  G Y               RG S  ++ GG  S   S G  +
Sbjct: 476 GGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGS-GGGY 534

Query: 416 HYGGEGRYEEYRGRSHEARSGGR-STDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY 474
             G  G +    G  H   SGG     + S G S   Y GG  S   S    GGG     
Sbjct: 535 GGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGG----- 589

Query: 475 QGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVG 507
                 +  GG S  +Y GG + S     YG G
Sbjct: 590 ------SGFGGESGGSYGGGEEASGSGGGYGGG 616



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 67/239 (28%), Positives = 80/239 (33%), Gaps = 83/239 (34%)

Query: 743 GGGRSLDANSSGRLPDAYSGGHDSS-SRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSG 801
           GG    +++ +G++     GG   S  R  R G GG Y            GG S   Y G
Sbjct: 460 GGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSY-----------GGGGSGGGYGG 508

Query: 802 GHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHY 861
           G  S       RGG              SGG    +Y GG  S           G GG Y
Sbjct: 509 GSGS-------RGG--------------SGG----SYGGGSGSGG---------GSGGGY 534

Query: 862 EEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSP 921
               G  H     G S   HSG                  G   +YG G       G S 
Sbjct: 535 GGGSGGGHS----GGSGGGHSG------------------GSGGNYGGG---SGSGGGSG 569

Query: 922 NAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGG 980
             YGGG G   S    G SH  G G     + G S  ++ GG ++S    G    YGGG
Sbjct: 570 GGYGGGSG---SRGGSGGSHGGGSG-----FGGESGGSYGGGEEAS----GSGGGYGGG 616



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 44/151 (29%), Positives = 53/151 (35%), Gaps = 20/151 (13%)

Query: 671 EYRGRLLDANSGGRSPDAYSGGHDSS-----SQSNRYGGGGRYEEYRGHSLDANSGGRSP 725
           ++    L  + GG      SGG   S     S S   GGGGR+    G+      GG S 
Sbjct: 5   QFSSSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGY------GGGSS 58

Query: 726 DTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGR 785
               RG   S    + GG G    A+S G       GG    SR      GG Y    G 
Sbjct: 59  RVCGRGGGGSFGYSYGGGSGGGFSASSLG-------GGFGGGSRGFGGASGGGYSSSGG- 110

Query: 786 SLDANSGGRSPNAYSGGHNSSSRNDPCRGGG 816
                 GG S   + GG+ S        GGG
Sbjct: 111 -FGGGFGGGSGGGFGGGYGSGFGGFGGFGGG 140



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 45/156 (28%), Positives = 53/156 (33%), Gaps = 20/156 (12%)

Query: 473 EYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSG 532
           ++    L  + GG      SGG   SS+S     GG     R  S     GG S     G
Sbjct: 5   QFSSSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRG 64

Query: 533 GHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYE 592
           G  S   SYG     GG G             GG SA +  GG    S+      GG Y 
Sbjct: 65  GGGSFGYSYG-----GGSG-------------GGFSASSLGGGFGGGSRGFGGASGGGYS 106

Query: 593 EYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGG 628
              G       GG S   + GG+ S        GGG
Sbjct: 107 SSGG--FGGGFGGGSGGGFGGGYGSGFGGFGGFGGG 140



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 45/164 (27%), Positives = 55/164 (33%), Gaps = 19/164 (11%)

Query: 593 EYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSG 652
           ++    L  + GG      SGG   SS+S     GG     R  S     GG S     G
Sbjct: 5   QFSSSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRG 64

Query: 653 GHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYR 712
           G  S G S  YGGG             + GG S  +  GG    S+      GG Y    
Sbjct: 65  GGGSFGYS--YGGG-------------SGGGFSASSLGGGFGGGSRGFGGASGGGYSSSG 109

Query: 713 GHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRL 756
           G       GG S   +  G+ S      +GG G        G L
Sbjct: 110 G--FGGGFGGGSGGGFGGGYGSGFGG--FGGFGGGAGGGDGGIL 149



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 48/154 (31%), Positives = 55/154 (35%), Gaps = 26/154 (16%)

Query: 555 YRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGG 614
           Y  RS     GG      SGG   SS S     GG              GGR  ++   G
Sbjct: 10  YLSRSGGGGGGGLG----SGGSIRSSYSRFSSSGG-----------GGGGGRFSSSSGYG 54

Query: 615 HDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGG--GGRYEEY 672
             SS    R GGG     Y G S     GG S  +  GG    G S  +GG  GG Y   
Sbjct: 55  GGSSRVCGRGGGGSFGYSYGGGS----GGGFSASSLGGGF--GGGSRGFGGASGGGYSSS 108

Query: 673 RGRLLDANSGGRSPDAYSGGHDSS-SQSNRYGGG 705
            G       GG S   + GG+ S       +GGG
Sbjct: 109 GG--FGGGFGGGSGGGFGGGYGSGFGGFGGFGGG 140



 Score = 38.9 bits (89), Expect = 0.026
 Identities = 54/191 (28%), Positives = 66/191 (34%), Gaps = 35/191 (18%)

Query: 883  GDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHR 942
            G    E+   G+       G    YGRG      +G S  +YGGG          G    
Sbjct: 461  GQEDFESSGAGKIGLGGRGGSGGSYGRGS-----RGGSGGSYGGG----------GSGGG 505

Query: 943  YGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGGGHYEEYQGSLPDAYSGDHDRSS 1002
            YGGG      RG S  ++ GG  S   S G      GGGH     G       G++   S
Sbjct: 506  YGGGSGS---RGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGS 562

Query: 1003 NSYGRSDRYSRGRDRVGRPDRGLPLPMETGSPPLHDSYSRSGCRV--PRGGGRQ----GG 1056
             S G S     G    G   RG       GS   H   S  G       GGG +    GG
Sbjct: 563  GSGGGSGGGYGG----GSGSRG-------GSGGSHGGGSGFGGESGGSYGGGEEASGSGG 611

Query: 1057 RFERGEGRSRY 1067
             +  G G+S +
Sbjct: 612  GYGGGSGKSSH 622



 Score = 37.7 bits (86), Expect = 0.058
 Identities = 48/169 (28%), Positives = 54/169 (31%), Gaps = 41/169 (24%)

Query: 308 GGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYS 367
           GG  G     G+  SYGGG     Y G S                     SR  S  +Y 
Sbjct: 482 GGSYGRGSRGGSGGSYGGGGSGGGYGGGSG--------------------SRGGSGGSYG 521

Query: 368 GGRSS---SSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNS-----SSNSYGQSHHYGG 419
           GG  S   S  GY      G       + G S   HSGG        S +  G    YGG
Sbjct: 522 GGSGSGGGSGGGYGGGSGGG-------HSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGG 574

Query: 420 EGRYEEYRGRSHEARSGGRSTDAHSRGRSDDA------YSGGHDSSSWS 462
                   G SH   SG       S G  ++A      Y GG   SS S
Sbjct: 575 GSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGKSSHS 623



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 47/165 (28%), Positives = 60/165 (36%), Gaps = 39/165 (23%)

Query: 430 SHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCC-----GGGGRYEEYQGRSLDANSG 484
           S+ +RSGG        G      SGG   SS+S        GGGGR+    G       G
Sbjct: 9   SYLSRSGG--------GGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSG-----YGG 55

Query: 485 GCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQS 544
           G S     GG  +  +S   G GG +  +   SL    GG S     G   +S   Y  S
Sbjct: 56  GSSRVCGRGGGGSFGYSYGGGSGGGFSAS---SLGGGFGGGS----RGFGGASGGGYSSS 108

Query: 545 HRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSS-SQSNRYGGG 588
             +GG               GG S   + GG+ S       +GGG
Sbjct: 109 GGFGG-------------GFGGGSGGGFGGGYGSGFGGFGGFGGG 140



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 42/154 (27%), Positives = 51/154 (33%), Gaps = 31/154 (20%)

Query: 392 YRGRSPDAHSGGRNSSSN---SYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRS 448
           Y  RS     GG  S  +   SY +    GG G              GGR +       S
Sbjct: 10  YLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGG-------------GGGRFS-------S 49

Query: 449 DDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGG 508
              Y GG   SS     GGGG +    G     + GG S  +  GG    S       GG
Sbjct: 50  SSGYGGG---SSRVCGRGGGGSFGYSYG---GGSGGGFSASSLGGGFGGGSRGFGGASGG 103

Query: 509 HYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYG 542
            Y  + G       GG S     GG+ S    +G
Sbjct: 104 GYSSSGG--FGGGFGGGSGGGFGGGYGSGFGGFG 135



 Score = 31.6 bits (70), Expect = 4.2
 Identities = 28/86 (32%), Positives = 32/86 (37%), Gaps = 19/86 (22%)

Query: 916 YQGRSPNAYGGGRGLNSS-NNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYG-- 972
           Y  RS    GGG G   S  +S+ R    GGGG              GGR SS   YG  
Sbjct: 10  YLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGG-------------GGGRFSSSSGYGGG 56

Query: 973 ---LSDRYGGGGHYEEYQGSLPDAYS 995
              +  R GGG     Y G     +S
Sbjct: 57  SSRVCGRGGGGSFGYSYGGGSGGGFS 82


>gi|14043070 heterogeneous nuclear ribonucleoprotein A1 isoform b
           [Homo sapiens]
          Length = 372

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 69/234 (29%), Positives = 92/234 (39%), Gaps = 57/234 (24%)

Query: 514 RGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYS 573
           RG S   N GG       GG    ++++G+   + G G +   G S      G S D Y+
Sbjct: 194 RGRSGSGNFGGGR-----GGGFGGNDNFGRGGNFSGRGGF---GGSRGGGGYGGSGDGYN 245

Query: 574 G-GHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEE 632
           G G+D       YGGGG    Y G S    SGG+       G         YGG G Y+ 
Sbjct: 246 GFGNDGG-----YGGGG--PGYSGGSRGYGSGGQGYGNQGSG---------YGGSGSYDS 289

Query: 633 YRGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGG 692
           Y       N+GG       GG    G  + +GGGG Y ++     + N+   +     GG
Sbjct: 290 Y-------NNGG-------GGGFGGGSGSNFGGGGSYNDFG----NYNNQSSNFGPMKGG 331

Query: 693 HDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGR 746
           +     S  YGGGG+Y      +   N G         G+  SS S  YG G R
Sbjct: 332 NFGGRSSGPYGGGGQY-----FAKPRNQG---------GYGGSSSSSSYGSGRR 371



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 67/223 (30%), Positives = 91/223 (40%), Gaps = 45/223 (20%)

Query: 634 RGRSLDANSGGRSPDAYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSG-G 692
           RGRS   N GG     + GG+D+ G+   + G G +   RG        G S D Y+G G
Sbjct: 194 RGRSGSGNFGGGRGGGF-GGNDNFGRGGNFSGRGGFGGSRG----GGGYGGSGDGYNGFG 248

Query: 693 HDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANS 752
           +D       YGGGG    Y G S    SGG+       G+  S   D Y  GG       
Sbjct: 249 NDGG-----YGGGG--PGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGG------- 294

Query: 753 SGRLPDAYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPC 812
                    GG    S S+ +GGGG Y ++   +  +++ G       GG +S     P 
Sbjct: 295 --------GGGFGGGSGSN-FGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSG----PY 341

Query: 813 RGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRY 855
            GGG+Y      +   N GG+       G  SSS+SY    R+
Sbjct: 342 GGGGQY-----FAKPRNQGGY-------GGSSSSSSYGSGRRF 372



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 68/242 (28%), Positives = 82/242 (33%), Gaps = 76/242 (31%)

Query: 783  RGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGR 842
            RGRS   N GG     + G       ND    GG +    G       GG+      GG 
Sbjct: 194  RGRSGSGNFGGGRGGGFGG-------NDNFGRGGNFSGRGGFGGSRGGGGY------GGS 240

Query: 843  DSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSNSYG 902
                N +     YGGGG                     +SG       SRG  S    YG
Sbjct: 241  GDGYNGFGNDGGYGGGG-------------------PGYSGG------SRGYGSGGQGYG 275

Query: 903  -RSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYR-------- 953
             +   YG  G Y+ Y       +GGG G N           +GGGG Y ++         
Sbjct: 276  NQGSGYGGSGSYDSYNNGGGGGFGGGSGSN-----------FGGGGSYNDFGNYNNQSSN 324

Query: 954  -GPSPDAHSGGRDSSIKSYGLSDRYGGGGHY---EEYQGSLPDAYSGDHDRSSNSYGRSD 1009
             GP    + GGR S          YGGGG Y      QG     Y G    SS+SYG   
Sbjct: 325  FGPMKGGNFGGRSSG--------PYGGGGQYFAKPRNQG----GYGG--SSSSSSYGSGR 370

Query: 1010 RY 1011
            R+
Sbjct: 371  RF 372



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 64/233 (27%), Positives = 79/233 (33%), Gaps = 50/233 (21%)

Query: 422 RYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDA 481
           +Y    G + E R      +  S   S    SG  +         GGGR   + G     
Sbjct: 166 KYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNF--------GGGRGGGFGGNDNFG 217

Query: 482 NSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSG--GHSSSSN 539
             G  S     GG          G GG  +   G   D   GG  P    G  G+ S   
Sbjct: 218 RGGNFSGRGGFGGSRGGG-----GYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQ 272

Query: 540 SYG-QSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYR--- 595
            YG Q   YGG G Y+        ++GG       GG    S SN +GGGG Y ++    
Sbjct: 273 GYGNQGSGYGGSGSYD------SYNNGG------GGGFGGGSGSN-FGGGGSYNDFGNYN 319

Query: 596 ------GRSLDANSGGRSPNAYSGG------------HDSSSWSHRYGGGGRY 630
                 G     N GGRS   Y GG            +  SS S  YG G R+
Sbjct: 320 NQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF 372



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 59/197 (29%), Positives = 78/197 (39%), Gaps = 37/197 (18%)

Query: 369 GRSSSSN-------GYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSS---NSYGQSHHYG 418
           GRS S N       G+  +D +G  G +    G       GG   S    N +G    YG
Sbjct: 195 GRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYG 254

Query: 419 GEGRYEEYRGRSHEARSGGRSTDAHSRGR----SDDAYS----GGHDSSSWSDCCGGGGR 470
           G G    Y G S    SGG+       G     S D+Y+    GG    S S+  GGGG 
Sbjct: 255 GGG--PGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNF-GGGGS 311

Query: 471 YEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTH 530
           Y ++   +  +++ G       GG+     S  YG GG Y      +   N GG      
Sbjct: 312 YNDFGNYNNQSSNFG----PMKGGNFGGRSSGPYGGGGQY-----FAKPRNQGGY----- 357

Query: 531 SGGHSSSSNSYGQSHRY 547
             G SSSS+SYG   R+
Sbjct: 358 --GGSSSSSSYGSGRRF 372



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 27/77 (35%), Positives = 48/77 (62%), Gaps = 1/77 (1%)

Query: 3  EADRPEKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADA 62
          E ++  KLFIGGL+ +T +++L++ F ++G +    +M+D  T +SRGF FVT+ +  + 
Sbjct: 9  EPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEV 68

Query: 63 KAAARDMNGKYLDGKAI 79
           AA      K +DG+ +
Sbjct: 69 DAAMNARPHK-VDGRVV 84



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 70/251 (27%), Positives = 95/251 (37%), Gaps = 70/251 (27%)

Query: 695 SSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSG 754
           SSSQ  R  G G +   RG     N      D + RG + S +    GG G S      G
Sbjct: 190 SSSQRGR-SGSGNFGGGRGGGFGGN------DNFGRGGNFSGR----GGFGGSRGGGGYG 238

Query: 755 RLPDAYSG-GHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCR 813
              D Y+G G+D       YGGGG    Y G S    SGG+       G+  S   D   
Sbjct: 239 GSGDGYNGFGNDGG-----YGGGG--PGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYN 291

Query: 814 GGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHS 873
            GG              GG     + GG  S+         +GGGG Y ++         
Sbjct: 292 NGG--------------GG----GFGGGSGSN---------FGGGGSYNDF--------- 315

Query: 874 RGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSD-HYGRGGCYEEYQGRSPNAYGGGRGLNS 932
                    G++  ++ + G     N  GRS   YG GG Y   + R+   YGG    +S
Sbjct: 316 ---------GNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFA-KPRNQGGYGG----SS 361

Query: 933 SNNSHGRSHRY 943
           S++S+G   R+
Sbjct: 362 SSSSYGSGRRF 372



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 57/201 (28%), Positives = 78/201 (38%), Gaps = 30/201 (14%)

Query: 393 RGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSG-GRSTDAHSRGRSDDA 451
           RGRS   + GG        G+   +GG   +   RG +   R G G S      G S D 
Sbjct: 194 RGRSGSGNFGG--------GRGGGFGGNDNFG--RGGNFSGRGGFGGSRGGGGYGGSGDG 243

Query: 452 YSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYE 511
           Y+G  +   +    GGGG    Y G S    SGG        G+  S   D Y  GG   
Sbjct: 244 YNGFGNDGGY----GGGG--PGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGG-- 295

Query: 512 ENRGHSLDANSGGRSPDTHSGGHSSSSNSYG--QSHRYGGEGRYEYRGRSHDAHSGG--C 567
              G    +N GG       G +++ S+++G  +   +GG     Y G       GG   
Sbjct: 296 GGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGG-------GGQYF 348

Query: 568 SADAYSGGHDSSSQSNRYGGG 588
           +     GG+  SS S+ YG G
Sbjct: 349 AKPRNQGGYGGSSSSSSYGSG 369



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 41/132 (31%), Positives = 59/132 (44%), Gaps = 11/132 (8%)

Query: 8   EKLFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADAKAAA- 66
           +K+F+GG+   T+E  L+  F +YG I  + +M DR + K RGFAFVTF+          
Sbjct: 105 KKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVI 164

Query: 67  ---RDMNGKYLDGKAIMVAQTIKPAFKSSRWVPPTPGSGSRSRFSHRTRGGGSSPQRPPS 123
                +NG   + +  +  Q +  A  S R      GSG+        RGGG        
Sbjct: 165 QKYHTVNGHNCEVRKALSKQEMASASSSQR---GRSGSGNFG----GGRGGGFGGNDNFG 217

Query: 124 QGRPDDGRGYAG 135
           +G    GRG  G
Sbjct: 218 RGGNFSGRGGFG 229



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 56/248 (22%), Positives = 78/248 (31%), Gaps = 67/248 (27%)

Query: 267 SSVPDYRPLRGDGNQNGYRGRDHEYTDHPSKGSYREPLKSYGGPCGAAPVWGTPPSYGGG 326
           S+    R   G GN  G RG      D+  +G        +GG  G     G+   Y G 
Sbjct: 188 SASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGF 247

Query: 327 CRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYSGGR---SSSSNGY-SRSDR 382
                Y G  P                            YSGG     S   GY ++   
Sbjct: 248 GNDGGYGGGGP---------------------------GYSGGSRGYGSGGQGYGNQGSG 280

Query: 383 YGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDA 442
           YG  G Y+ Y         GG  S         ++GG G Y ++   ++++ + G     
Sbjct: 281 YGGSGSYDSYNNGGGGGFGGGSGS---------NFGGGGSYNDFGNYNNQSSNFGPMKGG 331

Query: 443 HSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSD 502
           +  GRS   Y             GGGG+Y               +     GG+  SS S 
Sbjct: 332 NFGGRSSGPY-------------GGGGQY--------------FAKPRNQGGYGGSSSSS 364

Query: 503 RYGVGGHY 510
            YG G  +
Sbjct: 365 SYGSGRRF 372



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 35/131 (26%), Positives = 49/131 (37%), Gaps = 21/131 (16%)

Query: 892  RGRDSFSN-------SYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYG 944
            RGR    N        +G +D++GRGG +    G   +  GGG G        G    Y 
Sbjct: 194  RGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYG--------GSGDGYN 245

Query: 945  GGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDR---YGGGGHYEEYQGSLPDAYSGDHDRS 1001
            G G    Y G  P    G R       G  ++   YGG G Y+ Y       + G    S
Sbjct: 246  GFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGG---S 302

Query: 1002 SNSYGRSDRYS 1012
             +++G    Y+
Sbjct: 303  GSNFGGGGSYN 313


>gi|171916097 repetin [Homo sapiens]
          Length = 784

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 113/549 (20%), Positives = 191/549 (34%), Gaps = 65/549 (11%)

Query: 516  HSLDANS-GGRSPDTHSGGHSSSSNSY----GQSHRYGGEGRYEYRGRSHDAHSGGCSAD 570
            H LD  S GGR+     G   +    +    G+ HR   E   E R  SH +       D
Sbjct: 87   HKLDNKSHGGRTSQQERGQEGAQDCKFPGNTGRQHRQRHE---EERQNSHHSQPERQDGD 143

Query: 571  AYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRY 630
            ++ G  +   + + +G        +    D +S    P         +  S R      +
Sbjct: 144  SHHGQPERQDRDSHHG--------QSEKQDRDSHHSQPERQDRDSHHNQ-SERQDKDFSF 194

Query: 631  EEYRGRSLDANSGGR------SPDAYSGGH-------DSSGQSNCYGGGGRYEEYRGRLL 677
            ++   +S D++SG +      S  A   GH       +   Q + YG   R+ +    L 
Sbjct: 195  DQSERQSQDSSSGKKVSHKSTSGQAKWQGHIFALNRCEKPIQDSHYGQSERHTQQSETLG 254

Query: 678  DANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGRSPDTYSRGH-DSSS 736
             A+   ++    SG +   S+      G    + +G S       R   +Y  G  D   
Sbjct: 255  QASHFNQTNQQKSGSYCGQSERLGQELGCGQTDRQGQSSHYGQTDRQDQSYHYGQTDRQG 314

Query: 737  QSDHYGGGGRSLDANSSGRLPD-----AYSGGHDSSSRSHRY------GGGGRYEEYRGR 785
            QS HY    R   ++   + PD     ++ G  D   + + Y      G G  Y +   +
Sbjct: 315  QSSHYSQTDRQGQSSHYSQ-PDRQGQSSHYGQMDRKGQCYHYDQTNRQGQGSHYSQPNRQ 373

Query: 786  SLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEEN--RGHSLDANSGGHSPNAYSGGRD 843
               ++ G       S  +  + R D     G+ E      H    +  G   +     R 
Sbjct: 374  GQSSHYGQPDTQDQSSHYGQTDRQDQSSHYGQTERQGQSSHYSQMDRQGQGSHYGQTDRQ 433

Query: 844  SSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSF------ 897
              S+ Y +  R G   HY +   +   +H  G++       HY++   +G+ S       
Sbjct: 434  GQSSHYGQPDRQGQNSHYGQTDRQGQSSHY-GQTDRQGQSSHYSQPDKQGQSSHYGKIDR 492

Query: 898  ---SNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGGRYEEYRG 954
               S  YG+ D  G+   Y +   +  + + G       ++ + +  R G    Y +   
Sbjct: 493  QDQSYHYGQPDGQGQSSHYGQTDRQGQSFHYGQPDRQGQSSHYSQMDRQGQSSHYGQTDR 552

Query: 955  PSPDAHSGGRDSSIKS--YGLSDRYGGGGHYEEYQ-GSLPDA---YSGDHDRSSNSY--- 1005
                +H G  D   +S  YG +DR G   HY + Q G +      + G       SY   
Sbjct: 553  QGQSSHYGQTDRQGQSYHYGQTDRQGQSSHYIQSQTGEIQGQNKYFQGTEGTRKASYVEQ 612

Query: 1006 -GRSDRYSR 1013
             GRS R S+
Sbjct: 613  SGRSGRLSQ 621



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 132/613 (21%), Positives = 212/613 (34%), Gaps = 82/613 (13%)

Query: 370 RSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSH---HYGGEGRYEEY 426
           R    + +++S+R  ++  +++   +S D+ SG + S  ++ GQ+    H     R E+ 
Sbjct: 175 RQDRDSHHNQSERQDKDFSFDQSERQSQDSSSGKKVSHKSTSGQAKWQGHIFALNRCEKP 234

Query: 427 RGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGC 486
              SH  +S   +  + + G++          S     CG   R  +  G       G  
Sbjct: 235 IQDSHYGQSERHTQQSETLGQASHFNQTNQQKS--GSYCGQSERLGQELGCGQTDRQGQS 292

Query: 487 SPEAYSGGHDNS---SWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQ 543
           S    +   D S     +DR G   HY +        +  G+S           S+ YGQ
Sbjct: 293 SHYGQTDRQDQSYHYGQTDRQGQSSHYSQ-------TDRQGQSSHYSQPDRQGQSSHYGQ 345

Query: 544 SHRYGGEGRYEYRGR----SHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSL 599
             R G    Y+   R    SH +        ++ G  D+  QS+ YG          R  
Sbjct: 346 MDRKGQCYHYDQTNRQGQGSHYSQPNRQGQSSHYGQPDTQDQSSHYG-------QTDRQD 398

Query: 600 DANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSG---GRSPDAYSGGHDS 656
            ++  G++       H S     R G G  Y +   +   ++ G    +  +++ G  D 
Sbjct: 399 QSSHYGQTERQGQSSHYSQ--MDRQGQGSHYGQTDRQGQSSHYGQPDRQGQNSHYGQTDR 456

Query: 657 SGQSNCYGGGGR--------YEEYRGRLLDANSGGRSPDAYSGGH-DSSSQSNRYGGGGR 707
            GQS+ YG   R          + +G+        R   +Y  G  D   QS+ YG   R
Sbjct: 457 QGQSSHYGQTDRQGQSSHYSQPDKQGQSSHYGKIDRQDQSYHYGQPDGQGQSSHYGQTDR 516

Query: 708 --------YEEYRGHSLDANSGGRSPDTYSRGH-DSSSQSDHYGGGGRSLDANSSGRLPD 758
                     + +G S   +   R   +   G  D   QS HYG   R   +   G+   
Sbjct: 517 QGQSFHYGQPDRQGQSSHYSQMDRQGQSSHYGQTDRQGQSSHYGQTDRQGQSYHYGQTDR 576

Query: 759 AYSGGHDSSSRSHRYGGGGRY----EEYRGRSLDANSG--GRSPNAYSG-------GHNS 805
                H   S++    G  +Y    E  R  S    SG  GR      G       G   
Sbjct: 577 QGQSSHYIQSQTGEIQGQNKYFQGTEGTRKASYVEQSGRSGRLSQQTPGQEGYQNQGQGF 636

Query: 806 SSRNDPCRGGGRYE-----ENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYG---- 856
            SR+    G   +E     ++  H L A      P  +  GRD  S S ++ HR      
Sbjct: 637 QSRDSQQNGHQVWEPEEDSQHHQHKLLAQIQQERPLCHK-GRDWQSCSSEQGHRQAQTRQ 695

Query: 857 ----GGGHY--EEYRGRSHDTHS----RGRSPDAHSGDHYTEAYSRGRDSFSNSYGRSDH 906
               G  H+  EE   ++ D HS     G         H  E   + RD  ++ + +S  
Sbjct: 696 SHGEGLSHWAEEEQGHQTWDRHSHESQEGPCGTQDRRTHKDEQNHQRRDRQTHEHEQSHQ 755

Query: 907 YGRGGCYEEYQGR 919
                 +E+ Q R
Sbjct: 756 RRDRQTHEDKQNR 768



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 111/528 (21%), Positives = 182/528 (34%), Gaps = 79/528 (14%)

Query: 360 DHSPKAYSGG---RSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHH 416
           D   ++Y  G   R   S+ YS++DR G+   Y +   +   +H G      +  GQ +H
Sbjct: 299 DRQDQSYHYGQTDRQGQSSHYSQTDRQGQSSHYSQPDRQGQSSHYG----QMDRKGQCYH 354

Query: 417 YGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQG 476
           Y    R  +    S   R G  S       +   ++ G  D    S   G      E QG
Sbjct: 355 YDQTNRQGQGSHYSQPNRQGQSSHYGQPDTQDQSSHYGQTDRQDQSSHYG----QTERQG 410

Query: 477 RSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTH-SGGHS 535
           +S                  + S  DR G G HY +       ++ G   PD      H 
Sbjct: 411 QS-----------------SHYSQMDRQGQGSHYGQTDRQGQSSHYG--QPDRQGQNSHY 451

Query: 536 SSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYR 595
             ++  GQS  YG   R      SH +        ++ G  D   QS  YG         
Sbjct: 452 GQTDRQGQSSHYGQTDRQGQ--SSHYSQPDKQGQSSHYGKIDRQDQSYHYG--------- 500

Query: 596 GRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGR-SPDAYSGGH 654
                    G+  +++ G  D    S  YG   R    +G+S   +   R    ++ G  
Sbjct: 501 ------QPDGQGQSSHYGQTDRQGQSFHYGQPDR----QGQSSHYSQMDRQGQSSHYGQT 550

Query: 655 DSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGH 714
           D  GQS+ YG   R  +       +   G++       H   SQ+    G  +Y +    
Sbjct: 551 DRQGQSSHYGQTDRQGQ-------SYHYGQTDRQGQSSHYIQSQTGEIQGQNKYFQGTEG 603

Query: 715 SLDAN---SGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHDSSSRSH 771
           +  A+     GRS    S+         + G G +S D+  +G     +    DS    H
Sbjct: 604 TRKASYVEQSGRS-GRLSQQTPGQEGYQNQGQGFQSRDSQQNGH--QVWEPEEDSQHHQH 660

Query: 772 RYGGGGRYEE---YRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRY-EENRGHSLD 827
           +     + E    ++GR        +S ++  G   + +R     G   + EE +GH   
Sbjct: 661 KLLAQIQQERPLCHKGRD------WQSCSSEQGHRQAQTRQSHGEGLSHWAEEEQGHQTW 714

Query: 828 ANSGGHSPNAYSGGRDSSSNSYDRSHRYGG---GGHYEEYRGRSHDTH 872
                 S     G +D  ++  +++H+        H + ++ R   TH
Sbjct: 715 DRHSHESQEGPCGTQDRRTHKDEQNHQRRDRQTHEHEQSHQRRDRQTH 762



 Score = 35.8 bits (81), Expect = 0.22
 Identities = 71/342 (20%), Positives = 117/342 (34%), Gaps = 59/342 (17%)

Query: 266 HSSVPDYRPLRGDGNQNGYRGRDHEY--TDHPSKGS-YREPLKSYGGPCGAAPVWGTPPS 322
           H   PD +       Q   +G+   Y  TD   + S Y +P K            G    
Sbjct: 438 HYGQPDRQGQNSHYGQTDRQGQSSHYGQTDRQGQSSHYSQPDKQ-----------GQSSH 486

Query: 323 YGGGCRYEE-YQGNSPDACSEGRSSEALPVVLPDAYSR-DHSPKAYSGG---RSSSSNGY 377
           YG   R ++ Y    PD   +G+SS          Y + D   +++  G   R   S+ Y
Sbjct: 487 YGKIDRQDQSYHYGQPDG--QGQSSH---------YGQTDRQGQSFHYGQPDRQGQSSHY 535

Query: 378 SRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGG 437
           S+ DR G+   Y +   +   +H G     ++  GQS+HYG   R  +    SH  +S  
Sbjct: 536 SQMDRQGQSSHYGQTDRQGQSSHYG----QTDRQGQSYHYGQTDRQGQ---SSHYIQS-- 586

Query: 438 RSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGGHDN 497
           ++ +   + +      G   +S        G   ++  G+    N G       S  + +
Sbjct: 587 QTGEIQGQNKYFQGTEGTRKASYVEQSGRSGRLSQQTPGQEGYQNQGQGFQSRDSQQNGH 646

Query: 498 SSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSG----------GH--SSSSNSYGQSH 545
             W           ++  H L A      P  H G          GH  + +  S+G+  
Sbjct: 647 QVWEPE-----EDSQHHQHKLLAQIQQERPLCHKGRDWQSCSSEQGHRQAQTRQSHGEGL 701

Query: 546 RYGGE---GRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNR 584
            +  E   G   +   SH++  G C         D  +   R
Sbjct: 702 SHWAEEEQGHQTWDRHSHESQEGPCGTQDRRTHKDEQNHQRR 743


>gi|109255251 loricrin [Homo sapiens]
          Length = 312

 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 89/316 (28%), Positives = 107/316 (33%), Gaps = 46/316 (14%)

Query: 531 SGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGC 590
           SGG      S G     GG G +   G    +   GC    YSGG         Y GGGC
Sbjct: 20  SGGGGGGGGSGG-----GGCGFFGGGGSGGGSSGSGCG---YSGG-------GGYSGGGC 64

Query: 591 YEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAY 650
                      +SGG       G    S  S +Y GGG           +  GG    + 
Sbjct: 65  G--------GGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSS 116

Query: 651 SGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEE 710
            GG  S G S C+  GG            +SGG S    SGG   S Q+       + + 
Sbjct: 117 GGGGSSGGGSGCFSSGG----------GGSSGGGSGCFSSGGGGFSGQA------VQCQS 160

Query: 711 YRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSGGHD----S 766
           Y G S   +SGG S   +S G    S    Y GGG      SSG     Y         S
Sbjct: 161 YGGVSSGGSSGGGS-GCFSSGGGGGSVCG-YSGGGSGCGGGSSGGSGSGYVSSQQVTQTS 218

Query: 767 SSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSL 826
            +    YGGG       G S   +SGG   ++  GG  SS     C   G      G S 
Sbjct: 219 CAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGG-GSSGIGSGCIISGGGSVCGGGSS 277

Query: 827 DANSGGHSPNAYSGGR 842
               GG S      G+
Sbjct: 278 GGGGGGSSVGGSGSGK 293



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 93/319 (29%), Positives = 112/319 (35%), Gaps = 79/319 (24%)

Query: 466 GGGGRYEEYQGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGR 525
           GGGG           +  GGC    + GG  +   S   G G  Y    G+S     GG 
Sbjct: 25  GGGG-----------SGGGGCG---FFGGGGSGGGSSGSGCG--YSGGGGYSGGGCGGGS 68

Query: 526 SPDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRY 585
           S     GG        G S +Y G G            SGG S    SGG          
Sbjct: 69  SGGGGGGGIGGCGGGSGGSVKYSGGG----------GSSGGGSGCFSSGG---------- 108

Query: 586 GGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSS---SWSHRYGGGGRYEEYRGRSLDANS 642
           GG GC+    G S    SGG S    SGG  SS   S     GGGG    + G+++   S
Sbjct: 109 GGSGCFSSGGGGS----SGGGSGCFSSGGGGSSGGGSGCFSSGGGG----FSGQAVQCQS 160

Query: 643 GGRSPDAYSGGHDSSGQSNCY---GGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQS 699
            G      S G  S G S C+   GGGG    Y G    +  GG S      G+ SS Q 
Sbjct: 161 YG----GVSSGGSSGGGSGCFSSGGGGGSVCGYSGG--GSGCGGGSSGGSGSGYVSSQQV 214

Query: 700 NR--------YGGGGRYEEYRGHSLDANSGGRSPDTYSRGHDS---------------SS 736
            +        YGGG       G S   +SGG    +   G  S                 
Sbjct: 215 TQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGG 274

Query: 737 QSDHYGGGGRSLDANSSGR 755
            S   GGGG S+  + SG+
Sbjct: 275 GSSGGGGGGSSVGGSGSGK 293



 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 78/293 (26%), Positives = 99/293 (33%), Gaps = 29/293 (9%)

Query: 436 GGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDA-NSGGCSPEAYSGG 494
           GG  +     G      SGG  S S     GGGG    Y G      +SGG       G 
Sbjct: 25  GGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGG----YSGGGCGGGSSGGGGGGGIGGC 80

Query: 495 HDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQSHRYGGEGRYE 554
              S  S +Y  GG           ++ GG    +  GG S   +S G     GG G + 
Sbjct: 81  GGGSGGSVKYSGGG----------GSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFS 130

Query: 555 YRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRS--LDANSGGRSPNAYS 612
             G        GC +    G    + Q   YGG        G S    +  GG S   YS
Sbjct: 131 SGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYS 190

Query: 613 GGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGRSPDAYSGGHDSSGQSNCY--GGGGRYE 670
           GG          G G  Y   +  +  + +   S    S G   SG S C+  GGGG   
Sbjct: 191 GGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSS 250

Query: 671 EYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRYEEYRGHSLDANSGGR 723
              G     +SG  S    SGG       +  GGGG      G S+  +  G+
Sbjct: 251 GCGG----GSSGIGSGCIISGGGSVCGGGSSGGGGG------GSSVGGSGSGK 293



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 81/305 (26%), Positives = 97/305 (31%), Gaps = 44/305 (14%)

Query: 306 SYGGPCGAAPVWGTPP-SYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPK 364
           S GG CG     G+   S G GC Y    G S   C  G S       +           
Sbjct: 29  SGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSV 88

Query: 365 AYSGGRSSSSNGYSR-SDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRY 423
            YSGG  SS  G    S   G  GC+    G S    SGG +   +S G     GG G +
Sbjct: 89  KYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGS----SGGGSGCFSSGGGGSSGGGSGCF 144

Query: 424 EEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANS 483
                    +  GG  +    + +S    S G  S   S C   GG              
Sbjct: 145 ---------SSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGG-------------- 181

Query: 484 GGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSYGQ 543
           GG S   YSGG          G G  Y      S        +P    GG SS     G 
Sbjct: 182 GGGSVCGYSGGGSGCGGGSSGGSGSGYVS----SQQVTQTSCAPQPSYGGGSSGGGGSGG 237

Query: 544 SHRY--GGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDA 601
           S  +  GG G     G        GC     SGG       +  GGGG      G S+  
Sbjct: 238 SGCFSSGGGGGSSGCGGGSSGIGSGC---IISGGGSVCGGGSSGGGGG------GSSVGG 288

Query: 602 NSGGR 606
           +  G+
Sbjct: 289 SGSGK 293



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 77/286 (26%), Positives = 87/286 (30%), Gaps = 44/286 (15%)

Query: 368 GGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYR 427
           GG S S  GYS    Y   GC             GG +      G     GG G   +Y 
Sbjct: 44  GGSSGSGCGYSGGGGYSGGGC------------GGGSSGGGGGGGIGGCGGGSGGSVKYS 91

Query: 428 GRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEYQGRSLDANSGGCS 487
           G      SGG S    S G     +S G   SS     GGG       G        GC 
Sbjct: 92  GGG--GSSGGGSGCFSSGGGGSGCFSSGGGGSS-----GGGSGCFSSGGGGSSGGGSGCF 144

Query: 488 PEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGHSSSSNSY--GQSH 545
                G    +     YG         G S   +SGG S    SGG   S   Y  G S 
Sbjct: 145 SSGGGGFSGQAVQCQSYG---------GVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSG 195

Query: 546 RYGGEGRYEYRG--RSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANS 603
             GG       G   S       C+     GG   SS     GG GC+    G       
Sbjct: 196 CGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGG--GSSGGGGSGGSGCFSSGGGGGSSGCG 253

Query: 604 GGRSPNA----YSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSGGR 645
           GG S        SGG          GGGG      G S+  +  G+
Sbjct: 254 GGSSGIGSGCIISGGGSVCGGGSSGGGGG------GSSVGGSGSGK 293



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 80/291 (27%), Positives = 90/291 (30%), Gaps = 62/291 (21%)

Query: 703 GGGGRYEEYRGHSLDANSGGRSPDTYSRGHDSSSQSDHYGGGGRSLDANSSGRLPDAYSG 762
           GGGG      G       GG S      G  SS     Y GGG              YSG
Sbjct: 21  GGGGGGGGSGGGGCGFFGGGGS------GGGSSGSGCGYSGGG-------------GYSG 61

Query: 763 GHDSSSRSHRYGGGG--RYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPC--RGGGRY 818
           G      S   GGGG        G S+  + GG S    SG  +S      C   GGG  
Sbjct: 62  GGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGG-- 119

Query: 819 EENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSHRYGGGGHYEEYRGRSHDTHSRGRSP 878
                     +SGG S    SGG  SS          GGG   +  + +S+   S G S 
Sbjct: 120 ---------GSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSS 170

Query: 879 DAHSGDHYTEAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSS----- 933
              SG      +S G              G GG    Y G      GG  G + S     
Sbjct: 171 GGGSG-----CFSSG--------------GGGGSVCGYSGGGSGCGGGSSGGSGSGYVSS 211

Query: 934 ----NNSHGRSHRYGGGGRYEEYRGPSPDAHSGGRDSSIKSYGLSDRYGGG 980
                 S      YGGG       G S    SGG   S    G S   G G
Sbjct: 212 QQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSG 262


>gi|9558733 transformer-2 alpha [Homo sapiens]
          Length = 282

 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 57/153 (37%), Positives = 75/153 (49%), Gaps = 18/153 (11%)

Query: 10  LFIGGLNLKTDEKALKAEFGKYGHIIKVFLMKDRKTNKSRGFAFVTFESPADAKAAARDM 69
           L + GL+L T E+ L+  F +YG +  V ++ D++T +SRGFAFV FE   D+K A    
Sbjct: 121 LGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRGFAFVYFERIDDSKEAMERA 180

Query: 70  NGKYLDGKAIMVAQTIKPAFKSSRWVPPTPG--------SGSRSRFSHRTRGGGSSPQRP 121
           NG  LDG+ I V  +I     + R   PTPG        SG          GGG   +R 
Sbjct: 181 NGMELDGRRIRVDYSI-----TKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRD 235

Query: 122 PSQGRPDDGRGYAGYFDLWPYRAPMPRKRGPPP 154
               R  D RGY  Y D + YR    R+R P P
Sbjct: 236 SYYDRGYD-RGYDRYED-YDYRY---RRRSPSP 263



 Score = 32.0 bits (71), Expect = 3.2
 Identities = 71/306 (23%), Positives = 93/306 (30%), Gaps = 52/306 (16%)

Query: 330 EEYQGNSPDACSEGRSSEALPV-VLPDAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGC 388
           EE      ++ S+ +S    P  V  ++ S   SP   S    S S   S+S        
Sbjct: 5   EENNFEGRESRSQSKSPTGTPARVKSESRSGSRSPSRVSKHSESHSRSRSKSRSRSRRHS 64

Query: 389 YEEYRGRSPDAHSGGRNSSSNSYGQSHHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRS 448
           +  Y      +HS  R S S SY           Y   R RSH   S  R     SR   
Sbjct: 65  HRRYTRSRSHSHSHRRRSRSRSY--------TPEYRRRRSRSHSPMS-NRRRHTGSRANP 115

Query: 449 D----------DAYSGGHD----SSSWSDCCGGGGRYEEYQGRSLDANSGGCSPEAYSGG 494
           D            Y+   D     S +    G    Y++  GRS            Y   
Sbjct: 116 DPNTCLGVFGLSLYTTERDLREVFSRYGPLSGVNVVYDQRTGRSRG------FAFVYFER 169

Query: 495 HDNSSWSDRYGVGGHYEENR---GHSLDANSGGRSP------DTHSGGHSSSSNSYGQSH 545
            D+S  +     G   +  R    +S+   +   +P       THSGG        G   
Sbjct: 170 IDDSKEAMERANGMELDGRRIRVDYSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGG 229

Query: 546 RYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEYRGRSLDANSGG 605
             GG  R  Y  R +D          Y    D   +  R      Y  YR RS    S  
Sbjct: 230 --GGRRRDSYYDRGYDR--------GYDRYEDYDYRYRRRSPSPYYSRYRSRS---RSRS 276

Query: 606 RSPNAY 611
            SP  Y
Sbjct: 277 YSPRRY 282



 Score = 31.6 bits (70), Expect = 4.2
 Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 7/104 (6%)

Query: 797 NAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRSH-RY 855
           N + G  + S    P     R +       ++ SG  SP+  S   +S S S  +S  R 
Sbjct: 7   NNFEGRESRSQSKSPTGTPARVKS------ESRSGSRSPSRVSKHSESHSRSRSKSRSRS 60

Query: 856 GGGGHYEEYRGRSHDTHSRGRSPDAHSGDHYTEAYSRGRDSFSN 899
               H    R RSH    R RS        Y    SR     SN
Sbjct: 61  RRHSHRRYTRSRSHSHSHRRRSRSRSYTPEYRRRRSRSHSPMSN 104


>gi|212549553 interleukin enhancer binding factor 3 isoform d [Homo
           sapiens]
          Length = 898

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 71/259 (27%), Positives = 101/259 (38%), Gaps = 29/259 (11%)

Query: 595 RGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDA------NSGGRSPD 648
           RGR    +  GR      GG +   + +   G G Y  Y G S  A      ++GG S +
Sbjct: 644 RGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYG-YGGNSATAGYSQFYSNGGHSGN 702

Query: 649 AYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRY 708
           A  GG    G S+ YG   + + Y   +   ++G + P    GG    S    YG G  Y
Sbjct: 703 ASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQP---HGGQQKPS----YGSG--Y 753

Query: 709 EEYRGHSLDANSGGRS--------PDTYSRGHDSSSQSDHYG--GGGRSLDANSSGRLPD 758
           + ++G     N    S           Y+ G  S S S+ Y   GGG   D N   +   
Sbjct: 754 QSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNY 813

Query: 759 AYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRY 818
           + SGG  S   S+  GG        G     + GG S     GG++ S+ N P  G G+ 
Sbjct: 814 SGSGGR-SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSP--GSGQN 870

Query: 819 EENRGHSLDANSGGHSPNA 837
                 S  ++ GG+  NA
Sbjct: 871 YSGPPSSYQSSQGGYGRNA 889



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 81/306 (26%), Positives = 111/306 (36%), Gaps = 52/306 (16%)

Query: 747  SLDANSSGRLPDAYSGGHDSSSRSHRYG---GGGRYEEY------RGRSLDANSGGRSPN 797
            +LDAN   R P    GG   +++ H  G   GG  + E       RGR    +  GR   
Sbjct: 599  ALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRG 658

Query: 798  AYSGGHNSSSRNDPCRGGGRY-----EENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRS 852
               GG N     +   G G Y         G+S   ++GGHS NA  GG      S    
Sbjct: 659  RGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYG 718

Query: 853  HRYGG------------------GGHYEEYRGRSHDTH-----SRGRSPDAHSGDHY--T 887
              Y G                  GG  +   G  + +H     S  +SP ++ G      
Sbjct: 719  SYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQ 778

Query: 888  EAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGG 947
            + Y+ G+ S+S S   +   G GG    Y+ +   +  GGR   +S  S G S+  G  G
Sbjct: 779  KGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHG 838

Query: 948  RYEEYRGPSPDAHSGGRDSSIKSYGLS-DRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYG 1006
             Y    G       GG     K  G S   Y   G  + Y G  P +Y      S   YG
Sbjct: 839  GYGGGSG-------GGSSYQGKQGGYSQSNYNSPGSGQNYSGP-PSSYQS----SQGGYG 886

Query: 1007 RSDRYS 1012
            R+  +S
Sbjct: 887  RNADHS 892



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 87/309 (28%), Positives = 120/309 (38%), Gaps = 54/309 (17%)

Query: 478 SLDANSGGCSPEAYSGGHDNSS--WSDRYGVGG--HYE---------ENRGHSLDANSGG 524
           +LDAN    +P    GG   ++   +  +G+GG  H E           RG S+     G
Sbjct: 599 ALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRG 658

Query: 525 RS-PDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSN 583
           R     + GG+ ++   YG    YG  G     G S    +GG S +A  GG      S+
Sbjct: 659 RGFGGANHGGYMNAGAGYGS---YGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSS 715

Query: 584 RYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSG 643
            YG     + Y       ++G + P+   GG    S    YG G  Y+ ++G+    N  
Sbjct: 716 GYGSYYQGDNYNSPVPPKHAGKKQPH---GGQQKPS----YGSG--YQSHQGQQQSYNQS 766

Query: 644 GRS--------PDAYSGGHDSSGQSNCY----GGGGRYEEYRGRLLDANSGGRS-PDAYS 690
             S           Y+ G  S   SN Y    GGGG    Y  +   + SGGRS  ++Y 
Sbjct: 767 PYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYG 826

Query: 691 GGHDSSSQSNR--YGGGGRYEEYRGHSLDANSGGRSPDTYS--------RGHDSSSQSDH 740
            G  S +  +   YGGG       G S     GG S   Y+         G  SS QS  
Sbjct: 827 SGGASYNPGSHGGYGGGSG----GGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQ 882

Query: 741 YGGGGRSLD 749
            GG GR+ D
Sbjct: 883 -GGYGRNAD 890



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 79/328 (24%), Positives = 118/328 (35%), Gaps = 47/328 (14%)

Query: 355 DAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQS 414
           DA  +  +P    GG   ++  ++    +G  G         P+    GR  S    G+ 
Sbjct: 601 DANKKKRAPVPVRGGPKFAAKPHNPG--FGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRG 658

Query: 415 HHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY 474
             +GG   +  Y        S G   ++ + G S    +GGH  ++     GGGG    Y
Sbjct: 659 RGFGG-ANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGY 717

Query: 475 QGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGH 534
                  N     P  ++G         +   G  Y+ ++G     N   +SP ++ G  
Sbjct: 718 GSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYN---QSPYSNYGPP 774

Query: 535 SSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEY 594
                 Y       G+G Y Y                      S+S ++  GGGG    Y
Sbjct: 775 QGKQKGYNH-----GQGSYSY----------------------SNSYNSPGGGGGSDYNY 807

Query: 595 RGRSLDANSGGRS-PNAY-SGGHDSSSWSH-RYGGGGRYEEYRGRSLDANSGGRSPDAYS 651
             +   + SGGRS  N+Y SGG   +  SH  YGGG       G S     GG S   Y+
Sbjct: 808 ESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSG----GGSSYQGKQGGYSQSNYN 863

Query: 652 ---GGHDSSGQSNCY----GGGGRYEEY 672
               G + SG  + Y    GG GR  ++
Sbjct: 864 SPGSGQNYSGPPSSYQSSQGGYGRNADH 891



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 75/306 (24%), Positives = 110/306 (35%), Gaps = 47/306 (15%)

Query: 677 LDANSGGRSPDAYSGGHDSSSQSNRYG---GGGRYEEY----------RGHSLDANSGGR 723
           LDAN   R+P    GG   +++ +  G   GG  + E           RG S+     GR
Sbjct: 600 LDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGR 659

Query: 724 SPDTYSRGHDSSSQSDH--YGGGGRSLDANSSGRLPDAYS-GGHDSSSRSHRYGGGGRYE 780
                + G   ++ + +  YG GG S  A  S      YS GGH  ++     GGGG   
Sbjct: 660 GFGGANHGGYMNAGAGYGSYGYGGNSATAGYS----QFYSNGGHSGNASGGGGGGGGGSS 715

Query: 781 EYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHS----PN 836
            Y       N     P  ++G             G  Y+ ++G     N   +S    P 
Sbjct: 716 GYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQ 775

Query: 837 AYSGGRDSSSNSYDRSHRY----GGGGHYEEYRGRSHDTHSRGRS-------------PD 879
               G +    SY  S+ Y    GGGG    Y  + + + S GRS             P 
Sbjct: 776 GKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPG 835

Query: 880 AHSGDHYTEAYSRGRDSFSNSYG--RSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSH 937
           +H G       S G  S+    G     +Y   G  + Y G  P++Y   +G    N  H
Sbjct: 836 SHGG---YGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSG-PPSSYQSSQGGYGRNADH 891

Query: 938 GRSHRY 943
             +++Y
Sbjct: 892 SMNYQY 897



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 91/352 (25%), Positives = 128/352 (36%), Gaps = 87/352 (24%)

Query: 143 RAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGP 202
           RAP+P + GP    +A+ PH          + G GM G          ++ + P     P
Sbjct: 607 RAPVPVRGGPK---FAAKPH----------NPGFGMGGPM--------HNEVPP-----P 640

Query: 203 PHKRAVPRSSLAR-------IGGSGMPG--KAPAVWGQDGYSGPRVREPLPPCRDPGDFV 253
           P+ R   R    R        GG+   G   A A +G  GY G                 
Sbjct: 641 PNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNS--------------- 685

Query: 254 PALRDYSRRYY--GHSSVPDYRPLRGDGNQNGY----RGRDHEYTDHPSKGSYREPLKSY 307
            A   YS+ Y   GHS         G G  +GY    +G ++     P     ++P   +
Sbjct: 686 -ATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQP---H 741

Query: 308 GGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYS 367
           GG           PSYG G  Y+ +QG          S+   P             K Y+
Sbjct: 742 GGQ--------QKPSYGSG--YQSHQGQQQSYNQSPYSNYGPP---------QGKQKGYN 782

Query: 368 GGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQ---SHHYGGEGRY- 423
            G+ S S   S +   G  G    Y  +   + SGGR S  NSYG    S++ G  G Y 
Sbjct: 783 HGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGR-SGGNSYGSGGASYNPGSHGGYG 841

Query: 424 -EEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY 474
                G S++ + GG S   ++   S   YSG    SS+    GG GR  ++
Sbjct: 842 GGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSG--PPSSYQSSQGGYGRNADH 891


>gi|24234750 interleukin enhancer binding factor 3 isoform a [Homo
           sapiens]
          Length = 894

 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 71/259 (27%), Positives = 101/259 (38%), Gaps = 29/259 (11%)

Query: 595 RGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDA------NSGGRSPD 648
           RGR    +  GR      GG +   + +   G G Y  Y G S  A      ++GG S +
Sbjct: 640 RGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYG-YGGNSATAGYSQFYSNGGHSGN 698

Query: 649 AYSGGHDSSGQSNCYGGGGRYEEYRGRLLDANSGGRSPDAYSGGHDSSSQSNRYGGGGRY 708
           A  GG    G S+ YG   + + Y   +   ++G + P    GG    S    YG G  Y
Sbjct: 699 ASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQP---HGGQQKPS----YGSG--Y 749

Query: 709 EEYRGHSLDANSGGRS--------PDTYSRGHDSSSQSDHYG--GGGRSLDANSSGRLPD 758
           + ++G     N    S           Y+ G  S S S+ Y   GGG   D N   +   
Sbjct: 750 QSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNY 809

Query: 759 AYSGGHDSSSRSHRYGGGGRYEEYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRY 818
           + SGG  S   S+  GG        G     + GG S     GG++ S+ N P  G G+ 
Sbjct: 810 SGSGGR-SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSP--GSGQN 866

Query: 819 EENRGHSLDANSGGHSPNA 837
                 S  ++ GG+  NA
Sbjct: 867 YSGPPSSYQSSQGGYGRNA 885



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 81/306 (26%), Positives = 111/306 (36%), Gaps = 52/306 (16%)

Query: 747  SLDANSSGRLPDAYSGGHDSSSRSHRYG---GGGRYEEY------RGRSLDANSGGRSPN 797
            +LDAN   R P    GG   +++ H  G   GG  + E       RGR    +  GR   
Sbjct: 595  ALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRG 654

Query: 798  AYSGGHNSSSRNDPCRGGGRY-----EENRGHSLDANSGGHSPNAYSGGRDSSSNSYDRS 852
               GG N     +   G G Y         G+S   ++GGHS NA  GG      S    
Sbjct: 655  RGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYG 714

Query: 853  HRYGG------------------GGHYEEYRGRSHDTH-----SRGRSPDAHSGDHY--T 887
              Y G                  GG  +   G  + +H     S  +SP ++ G      
Sbjct: 715  SYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQ 774

Query: 888  EAYSRGRDSFSNSYGRSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSHGRSHRYGGGG 947
            + Y+ G+ S+S S   +   G GG    Y+ +   +  GGR   +S  S G S+  G  G
Sbjct: 775  KGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHG 834

Query: 948  RYEEYRGPSPDAHSGGRDSSIKSYGLS-DRYGGGGHYEEYQGSLPDAYSGDHDRSSNSYG 1006
             Y    G       GG     K  G S   Y   G  + Y G  P +Y      S   YG
Sbjct: 835  GYGGGSG-------GGSSYQGKQGGYSQSNYNSPGSGQNYSGP-PSSYQS----SQGGYG 882

Query: 1007 RSDRYS 1012
            R+  +S
Sbjct: 883  RNADHS 888



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 87/309 (28%), Positives = 120/309 (38%), Gaps = 54/309 (17%)

Query: 478 SLDANSGGCSPEAYSGGHDNSS--WSDRYGVGG--HYE---------ENRGHSLDANSGG 524
           +LDAN    +P    GG   ++   +  +G+GG  H E           RG S+     G
Sbjct: 595 ALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRG 654

Query: 525 RS-PDTHSGGHSSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSN 583
           R     + GG+ ++   YG    YG  G     G S    +GG S +A  GG      S+
Sbjct: 655 RGFGGANHGGYMNAGAGYGS---YGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSS 711

Query: 584 RYGGGGCYEEYRGRSLDANSGGRSPNAYSGGHDSSSWSHRYGGGGRYEEYRGRSLDANSG 643
            YG     + Y       ++G + P+   GG    S    YG G  Y+ ++G+    N  
Sbjct: 712 GYGSYYQGDNYNSPVPPKHAGKKQPH---GGQQKPS----YGSG--YQSHQGQQQSYNQS 762

Query: 644 GRS--------PDAYSGGHDSSGQSNCY----GGGGRYEEYRGRLLDANSGGRS-PDAYS 690
             S           Y+ G  S   SN Y    GGGG    Y  +   + SGGRS  ++Y 
Sbjct: 763 PYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYG 822

Query: 691 GGHDSSSQSNR--YGGGGRYEEYRGHSLDANSGGRSPDTYS--------RGHDSSSQSDH 740
            G  S +  +   YGGG       G S     GG S   Y+         G  SS QS  
Sbjct: 823 SGGASYNPGSHGGYGGGSG----GGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQ 878

Query: 741 YGGGGRSLD 749
            GG GR+ D
Sbjct: 879 -GGYGRNAD 886



 Score = 63.9 bits (154), Expect = 8e-10
 Identities = 79/328 (24%), Positives = 118/328 (35%), Gaps = 47/328 (14%)

Query: 355 DAYSRDHSPKAYSGGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQS 414
           DA  +  +P    GG   ++  ++    +G  G         P+    GR  S    G+ 
Sbjct: 597 DANKKKRAPVPVRGGPKFAAKPHNPG--FGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRG 654

Query: 415 HHYGGEGRYEEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY 474
             +GG   +  Y        S G   ++ + G S    +GGH  ++     GGGG    Y
Sbjct: 655 RGFGG-ANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGY 713

Query: 475 QGRSLDANSGGCSPEAYSGGHDNSSWSDRYGVGGHYEENRGHSLDANSGGRSPDTHSGGH 534
                  N     P  ++G         +   G  Y+ ++G     N   +SP ++ G  
Sbjct: 714 GSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYN---QSPYSNYGPP 770

Query: 535 SSSSNSYGQSHRYGGEGRYEYRGRSHDAHSGGCSADAYSGGHDSSSQSNRYGGGGCYEEY 594
                 Y       G+G Y Y                      S+S ++  GGGG    Y
Sbjct: 771 QGKQKGYNH-----GQGSYSY----------------------SNSYNSPGGGGGSDYNY 803

Query: 595 RGRSLDANSGGRS-PNAY-SGGHDSSSWSH-RYGGGGRYEEYRGRSLDANSGGRSPDAYS 651
             +   + SGGRS  N+Y SGG   +  SH  YGGG       G S     GG S   Y+
Sbjct: 804 ESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSG----GGSSYQGKQGGYSQSNYN 859

Query: 652 ---GGHDSSGQSNCY----GGGGRYEEY 672
               G + SG  + Y    GG GR  ++
Sbjct: 860 SPGSGQNYSGPPSSYQSSQGGYGRNADH 887



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 75/306 (24%), Positives = 110/306 (35%), Gaps = 47/306 (15%)

Query: 677 LDANSGGRSPDAYSGGHDSSSQSNRYG---GGGRYEEY----------RGHSLDANSGGR 723
           LDAN   R+P    GG   +++ +  G   GG  + E           RG S+     GR
Sbjct: 596 LDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGR 655

Query: 724 SPDTYSRGHDSSSQSDH--YGGGGRSLDANSSGRLPDAYS-GGHDSSSRSHRYGGGGRYE 780
                + G   ++ + +  YG GG S  A  S      YS GGH  ++     GGGG   
Sbjct: 656 GFGGANHGGYMNAGAGYGSYGYGGNSATAGYS----QFYSNGGHSGNASGGGGGGGGGSS 711

Query: 781 EYRGRSLDANSGGRSPNAYSGGHNSSSRNDPCRGGGRYEENRGHSLDANSGGHS----PN 836
            Y       N     P  ++G             G  Y+ ++G     N   +S    P 
Sbjct: 712 GYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQ 771

Query: 837 AYSGGRDSSSNSYDRSHRY----GGGGHYEEYRGRSHDTHSRGRS-------------PD 879
               G +    SY  S+ Y    GGGG    Y  + + + S GRS             P 
Sbjct: 772 GKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPG 831

Query: 880 AHSGDHYTEAYSRGRDSFSNSYG--RSDHYGRGGCYEEYQGRSPNAYGGGRGLNSSNNSH 937
           +H G       S G  S+    G     +Y   G  + Y G  P++Y   +G    N  H
Sbjct: 832 SHGG---YGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSG-PPSSYQSSQGGYGRNADH 887

Query: 938 GRSHRY 943
             +++Y
Sbjct: 888 SMNYQY 893



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 91/352 (25%), Positives = 128/352 (36%), Gaps = 87/352 (24%)

Query: 143 RAPMPRKRGPPPRHWASPPHKRATPSSLAHSVGCGMRGKAPTVSGQDGYSGLQPRRWAGP 202
           RAP+P + GP    +A+ PH          + G GM G          ++ + P     P
Sbjct: 603 RAPVPVRGGPK---FAAKPH----------NPGFGMGGPM--------HNEVPP-----P 636

Query: 203 PHKRAVPRSSLAR-------IGGSGMPG--KAPAVWGQDGYSGPRVREPLPPCRDPGDFV 253
           P+ R   R    R        GG+   G   A A +G  GY G                 
Sbjct: 637 PNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNS--------------- 681

Query: 254 PALRDYSRRYY--GHSSVPDYRPLRGDGNQNGY----RGRDHEYTDHPSKGSYREPLKSY 307
            A   YS+ Y   GHS         G G  +GY    +G ++     P     ++P   +
Sbjct: 682 -ATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQP---H 737

Query: 308 GGPCGAAPVWGTPPSYGGGCRYEEYQGNSPDACSEGRSSEALPVVLPDAYSRDHSPKAYS 367
           GG           PSYG G  Y+ +QG          S+   P             K Y+
Sbjct: 738 GGQ--------QKPSYGSG--YQSHQGQQQSYNQSPYSNYGPP---------QGKQKGYN 778

Query: 368 GGRSSSSNGYSRSDRYGEEGCYEEYRGRSPDAHSGGRNSSSNSYGQ---SHHYGGEGRY- 423
            G+ S S   S +   G  G    Y  +   + SGGR S  NSYG    S++ G  G Y 
Sbjct: 779 HGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGR-SGGNSYGSGGASYNPGSHGGYG 837

Query: 424 -EEYRGRSHEARSGGRSTDAHSRGRSDDAYSGGHDSSSWSDCCGGGGRYEEY 474
                G S++ + GG S   ++   S   YSG    SS+    GG GR  ++
Sbjct: 838 GGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSG--PPSSYQSSQGGYGRNADH 887


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.134    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,481,079
Number of Sequences: 37866
Number of extensions: 3508201
Number of successful extensions: 18551
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 491
Number of HSP's that attempted gapping in prelim test: 9205
Number of HSP's gapped (non-prelim): 3894
length of query: 1067
length of database: 18,247,518
effective HSP length: 113
effective length of query: 954
effective length of database: 13,968,660
effective search space: 13326101640
effective search space used: 13326101640
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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