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Search of human proteins with 223029410
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223029410 talin 1 [Homo sapiens]
(2541 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223029410 talin 1 [Homo sapiens] 4855 0.0
gi|156938343 talin 2 [Homo sapiens] 3768 0.0
gi|38045919 huntingtin interacting protein 1 [Homo sapiens] 127 1e-28
gi|48762942 huntingtin interacting protein-1-related [Homo sapiens] 109 4e-23
gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens] 109 4e-23
gi|13446229 mesoderm development candidate 1 [Homo sapiens] 101 8e-21
gi|29789006 fermitin family homolog 2 isoform 1 [Homo sapiens] 70 3e-11
gi|201861813 fermitin family homolog 2 isoform 2 [Homo sapiens] 69 6e-11
gi|4505257 moesin [Homo sapiens] 68 1e-10
gi|4506467 radixin [Homo sapiens] 68 1e-10
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 68 1e-10
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 65 7e-10
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 65 7e-10
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 65 7e-10
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 65 7e-10
gi|116686114 kindlin-1 [Homo sapiens] 64 2e-09
gi|28626504 fermitin family homolog 3 short form [Homo sapiens] 64 2e-09
gi|41281905 fermitin family homolog 3 long form [Homo sapiens] 64 2e-09
gi|161702986 ezrin [Homo sapiens] 63 4e-09
gi|21614499 ezrin [Homo sapiens] 63 4e-09
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 63 4e-09
gi|201861823 fermitin family homolog 2 isoform 3 [Homo sapiens] 62 6e-09
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 62 7e-09
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 60 3e-08
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 60 3e-08
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 60 3e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 60 4e-08
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 60 4e-08
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 60 4e-08
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 57 2e-07
>gi|223029410 talin 1 [Homo sapiens]
Length = 2541
Score = 4855 bits (12593), Expect = 0.0
Identities = 2541/2541 (100%), Positives = 2541/2541 (100%)
Query: 1 MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGI 60
MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGI
Sbjct: 1 MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGI 60
Query: 61 WLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIG 120
WLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIG
Sbjct: 61 WLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIG 120
Query: 121 ITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTL 180
ITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTL
Sbjct: 121 ITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTL 180
Query: 181 REQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAG 240
REQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAG
Sbjct: 181 REQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAG 240
Query: 241 FQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVK 300
FQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVK
Sbjct: 241 FQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVK 300
Query: 301 LARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWA 360
LARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWA
Sbjct: 301 LARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWA 360
Query: 361 ASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTML 420
ASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTML
Sbjct: 361 ASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTML 420
Query: 421 EDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQM 480
EDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQM
Sbjct: 421 EDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQM 480
Query: 481 HRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESK 540
HRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESK
Sbjct: 481 HRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESK 540
Query: 541 HEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLED 600
HEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLED
Sbjct: 541 HEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLED 600
Query: 601 EGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDT 660
EGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDT
Sbjct: 601 EGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDT 660
Query: 661 DPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACT 720
DPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACT
Sbjct: 661 DPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACT 720
Query: 721 KVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNE 780
KVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNE
Sbjct: 721 KVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNE 780
Query: 781 LLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAI 840
LLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAI
Sbjct: 781 LLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAI 840
Query: 841 KADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMA 900
KADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMA
Sbjct: 841 KADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMA 900
Query: 901 TNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVA 960
TNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVA
Sbjct: 901 TNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVA 960
Query: 961 EQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQL 1020
EQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQL
Sbjct: 961 EQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQL 1020
Query: 1021 SQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLP 1080
SQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLP
Sbjct: 1021 SQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLP 1080
Query: 1081 GETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAA 1140
GETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAA
Sbjct: 1081 GETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAA 1140
Query: 1141 LTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCV 1200
LTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCV
Sbjct: 1141 LTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCV 1200
Query: 1201 SCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQAS 1260
SCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQAS
Sbjct: 1201 SCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQAS 1260
Query: 1261 RGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK 1320
RGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK
Sbjct: 1261 RGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAK 1320
Query: 1321 ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENP 1380
ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENP
Sbjct: 1321 ALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENP 1380
Query: 1381 VQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAA 1440
VQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAA
Sbjct: 1381 VQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAA 1440
Query: 1441 AQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAK 1500
AQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAK
Sbjct: 1441 AQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAK 1500
Query: 1501 HTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRA 1560
HTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRA
Sbjct: 1501 HTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRA 1560
Query: 1561 ATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARAL 1620
ATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARAL
Sbjct: 1561 ATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARAL 1620
Query: 1621 AVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASL 1680
AVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASL
Sbjct: 1621 AVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASL 1680
Query: 1681 AAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEP 1740
AAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEP
Sbjct: 1681 AAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEP 1740
Query: 1741 LTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAV 1800
LTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAV
Sbjct: 1741 LTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAV 1800
Query: 1801 QMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRT 1860
QMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRT
Sbjct: 1801 QMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRT 1860
Query: 1861 AKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRV 1920
AKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRV
Sbjct: 1861 AKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRV 1920
Query: 1921 QELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACIT 1980
QELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACIT
Sbjct: 1921 QELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACIT 1980
Query: 1981 AASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGS 2040
AASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGS
Sbjct: 1981 AASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGS 2040
Query: 2041 QEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKA 2100
QEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKA
Sbjct: 2041 QEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKA 2100
Query: 2101 AAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVF 2160
AAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVF
Sbjct: 2101 AAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVF 2160
Query: 2161 CSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACK 2220
CSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACK
Sbjct: 2161 CSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACK 2220
Query: 2221 EAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSV 2280
EAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSV
Sbjct: 2221 EAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSV 2280
Query: 2281 TELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLN 2340
TELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLN
Sbjct: 2281 TELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLN 2340
Query: 2341 FEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMV 2400
FEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMV
Sbjct: 2341 FEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMV 2400
Query: 2401 AAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAG 2460
AAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAG
Sbjct: 2401 AAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAG 2460
Query: 2461 NAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARK 2520
NAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARK
Sbjct: 2461 NAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARK 2520
Query: 2521 KLAQIRQQQYKFLPSELRDEH 2541
KLAQIRQQQYKFLPSELRDEH
Sbjct: 2521 KLAQIRQQQYKFLPSELRDEH 2541
>gi|156938343 talin 2 [Homo sapiens]
Length = 2542
Score = 3768 bits (9772), Expect = 0.0
Identities = 1936/2543 (76%), Positives = 2250/2543 (88%), Gaps = 6/2543 (0%)
Query: 1 MVALSLKISIG--NVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKK 58
MVALSLKI + NVVKTMQFEPST VYDACR+IRER+PEA G SD+GLFLSD+DP+K
Sbjct: 1 MVALSLKICVRHCNVVKTMQFEPSTAVYDACRVIRERVPEAQTGQASDYGLFLSDEDPRK 60
Query: 59 GIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICAR 118
GIWLEAG+ LDYYMLRNGD +EY+KKQRP KIRMLDG+VKT+MVDDSKTV ++L+TIC+R
Sbjct: 61 GIWLEAGRTLDYYMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSR 120
Query: 119 IGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGR 178
IGITN++EYSL++E +EEKKEE TGTL+KD+TLLRDE+KMEKLK KLHTDD+LNWLDH R
Sbjct: 121 IGITNYEEYSLIQETIEEKKEEGTGTLKKDRTLLRDERKMEKLKAKLHTDDDLNWLDHSR 180
Query: 179 TLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEF 238
T REQGV+E+ETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSF+KACEF
Sbjct: 181 TFREQGVDENETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFEKACEF 240
Query: 239 AGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKG-ERKIFQAHKNCGQMSEIEAKVR 297
GFQ QIQFGPH E KHK GFLDLK+FLPKEY+KQ+G E++IFQ HKNCG+MSEIEAKV+
Sbjct: 241 GGFQAQIQFGPHVEHKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVK 300
Query: 298 YVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIK 357
YVKLARSL+TYGVSFFLVKEKMKGKNKLVPRLLGITK+ VMRVDEKTKEV+QEW LT +K
Sbjct: 301 YVKLARSLRTYGVSFFLVKEKMKGKNKLVPRLLGITKDSVMRVDEKTKEVLQEWPLTTVK 360
Query: 358 RWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEES 417
RWAASPKSFTLDFG+YQ+ YYSVQTTEGEQI+QLIAGYIDIILKKK+SKD FGLEGDEES
Sbjct: 361 RWAASPKSFTLDFGEYQESYYSVQTTEGEQISQLIAGYIDIILKKKQSKDRFGLEGDEES 420
Query: 418 TMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITS 477
TMLE+SVSPKKST+LQQQ+NR GK EHGSVALPA+MRSG+SGPE F VGSMP QQQ+
Sbjct: 421 TMLEESVSPKKSTILQQQFNRTGKAEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMV 480
Query: 478 GQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMD 537
GQMHRGHMPPLTSAQQAL GTIN+SM AVQ AQ L + D+LPPLGQD AS+ W +NK+D
Sbjct: 481 GQMHRGHMPPLTSAQQALMGTINTSMHAVQQAQDDLSELDSLPPLGQDMASRVWVQNKVD 540
Query: 538 ESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAAL 597
ESKHEIHSQVDAITAGTASVVNLTAGDPA+TDYTAVGCA+TTISSNLTEMS+GVKLLAAL
Sbjct: 541 ESKHEIHSQVDAITAGTASVVNLTAGDPADTDYTAVGCAITTISSNLTEMSKGVKLLAAL 600
Query: 598 LEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGE 657
++DE GSG LL+AA+ LAGAVS+LL++ QP S EPRQ +L AAG++GQASG+LL+QIGE
Sbjct: 601 MDDEVGSGEDLLRAARTLAGAVSDLLKAVQPTSGEPRQTVLTAAGSIGQASGDLLRQIGE 660
Query: 658 SDTDPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLV 717
++TD FQD LM LAKAVA+AAA LVLKAK+VAQ ED+ LQ +VIAAATQCALSTSQLV
Sbjct: 661 NETDERFQDVLMSLAKAVANAAAMLVLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLV 720
Query: 718 ACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQA 777
AC KVV+PTISSPVCQEQL+EAG+LV ++VE CV A QAAT D +LL+ V AAA+ V+QA
Sbjct: 721 ACAKVVSPTISSPVCQEQLIEAGKLVDRSVENCVRACQAATTDSELLKQVSAAASVVSQA 780
Query: 778 LNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLV 837
L++LLQHV+ A+ P GRYDQATDTI+ VTE+IFSSMGDAGEMVRQAR+LAQATSDLV
Sbjct: 781 LHDLLQHVRQFASRGEPIGRYDQATDTIMCVTESIFSSMGDAGEMVRQARVLAQATSDLV 840
Query: 838 NAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGL 897
NA+++DAE E D+ENS+KLL+AAK+LAD+TA+MVEAAKGAAA+P++E+QQQRLREAAEGL
Sbjct: 841 NAMRSDAEAEIDMENSKKLLAAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGL 900
Query: 898 RMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCK 957
R+ATNAAAQNAIKKK+V RLE AAKQAAA+ATQTIAA+Q+AA + K A Q L VQSCK
Sbjct: 901 RVATNAAAQNAIKKKIVNRLEVAAKQAAAAATQTIAASQNAAVSNKNPAAQQQL-VQSCK 959
Query: 958 AVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASA 1017
AVA+ IP LVQGVRGSQAQ + SAQLALI +SQ+FLQPG KMV++AKA+VPT+ DQA+A
Sbjct: 960 AVADHIPQLVQGVRGSQAQAEDLSAQLALIISSQNFLQPGSKMVSSAKAAVPTVSDQAAA 1019
Query: 1018 MQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLK 1077
MQLSQCAKNL T+LAELRTA+QKA EACGP+E+DSAL+ VQ L+ +LQ+ K AA + +LK
Sbjct: 1020 MQLSQCAKNLATSLAELRTASQKAHEACGPMEIDSALNTVQTLKNELQDAKMAAVESQLK 1079
Query: 1078 PLPGETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARG 1137
PLPGET+EKC QDLG+++KAV S++AQLL AQGNE+Y G+AAR+ A L++LAQAARG
Sbjct: 1080 PLPGETLEKCAQDLGSTSKAVGSSMAQLLTCAAQGNEHYTGVAARETAQALKTLAQAARG 1139
Query: 1138 VAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALN 1197
VAA T+DPA +LD+A DV++ ++ LI+EAK+A PGD E QQRLAQVAKAV+ +LN
Sbjct: 1140 VAASTTDPAAAHAMLDSARDVMEGSAMLIQEAKQALIAPGDAERQQRLAQVAKAVSHSLN 1199
Query: 1198 RCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELV 1257
CV+CLPGQ+DVD AL+++G++SK+LL DSLPPST FQEAQS LN+AAA LNQ+A E+V
Sbjct: 1200 NCVNCLPGQKDVDVALKSIGESSKKLLVDSLPPSTKPFQEAQSELNQAAADLNQSAGEVV 1259
Query: 1258 QASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLL 1317
A+RG +LA ASG+F DF FL+AG+EMAGQA ++ED+ QV+ NLK ISM+SSKLLL
Sbjct: 1260 HATRGQSGELAAASGKFSDDFDEFLDAGIEMAGQAQTKEDQIQVIGNLKNISMASSKLLL 1319
Query: 1318 AAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELL 1377
AAK+LS DP APN K+ LAAAARAVT+SINQLIT+CTQQAPGQKECDNALRELETV+ +L
Sbjct: 1320 AAKSLSVDPGAPNAKNLLAAAARAVTESINQLITLCTQQAPGQKECDNALRELETVKGML 1379
Query: 1378 ENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFT 1437
+NP +P++D+SYF C++SVMENSKVLGE+M GISQNAK G+LP FG+ + ASKALCG T
Sbjct: 1380 DNPNEPVSDLSYFDCIESVMENSKVLGESMAGISQNAKTGDLPAFGECVGIASKALCGLT 1439
Query: 1438 EAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATI 1497
EAAAQAAYLVG+SDPNSQAG QGLV+P QFARANQAIQMACQ+L +PG + +QVLSAATI
Sbjct: 1440 EAAAQAAYLVGISDPNSQAGHQGLVDPIQFARANQAIQMACQNLVDPGSSPSQVLSAATI 1499
Query: 1498 VAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQ 1557
VAKHTSALCN+CR+AS++T NP AKR FVQSAKEVANSTANLVKTIKALDG F+E+NR +
Sbjct: 1500 VAKHTSALCNACRIASSKTANPVAKRHFVQSAKEVANSTANLVKTIKALDGDFSEDNRNK 1559
Query: 1558 CRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTA 1617
CR ATAPL+EAV+NL+AFASNPEF SIPAQIS EG A EPI++SAKTMLES+ LI+TA
Sbjct: 1560 CRIATAPLIEAVENLTAFASNPEFVSIPAQISSEGSQAQEPILVSAKTMLESSSYLIRTA 1619
Query: 1618 RALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQ 1677
R+LA+NP+DPP+WSVLAGHS TVSDSIK LITS+RDKAPGQ EC+ +I +N C+RD++Q
Sbjct: 1620 RSLAINPKDPPTWSVLAGHSHTVSDSIKSLITSIRDKAPGQRECDYSIDGINRCIRDIEQ 1679
Query: 1678 ASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQY 1737
ASLAAVSQ LA R+ IS EAL Q+ + VQEI HLI+P+A AAR EA+QLGHKV+Q+A Y
Sbjct: 1680 ASLAAVSQSLATRDDISVEALQEQLTSVVQEIGHLIDPIATAARGEAAQLGHKVTQLASY 1739
Query: 1738 FEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALE 1797
FEPL LAAVG ASK L H QQM +LDQTKTLAESALQ+LY AKE GGNPK A HT +A+
Sbjct: 1740 FEPLILAAVGVASKILDHQQQMTVLDQTKTLAESALQMLYAAKEGGGNPK-AQHTHDAIT 1798
Query: 1798 EAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTM 1857
EA Q+M EAV+D+ TLNEAAS G+VGGMVD+I +A+++LDEG EP+G+FVDYQTT+
Sbjct: 1799 EAAQLMKEAVDDIMVTLNEAASEVGLVGGMVDAIAEAMSKLDEGTPPEPKGTFVDYQTTV 1858
Query: 1858 VRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIK 1917
V+ +KAIAVT QEM+TKS T+PEELG LA+Q+TSDYG LA + + AA AE EEIG I+
Sbjct: 1859 VKYSKAIAVTAQEMMTKSVTNPEELGGLASQMTSDYGHLAFQGQMAAATAEPEEIGFQIR 1918
Query: 1918 HRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQA 1977
RVQ+LGHGC LV KAGALQ P+D+YTK+ELIECAR V+EKVS VL+ALQAGN+GTQA
Sbjct: 1919 TRVQDLGHGCIFLVQKAGALQVCPTDSYTKRELIECARAVTEKVSLVLSALQAGNKGTQA 1978
Query: 1978 CITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNA 2037
CITAA+AVSGIIADLDTTIMFATAGTLN E +ETFADHRE ILKTAK LVEDTK+LV A
Sbjct: 1979 CITAATAVSGIIADLDTTIMFATAGTLNAENSETFADHRENILKTAKALVEDTKLLVSGA 2038
Query: 2038 AGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISA 2097
A + +KLAQAAQSS ATIT+LA+VVKLGAASLG++DPETQVVLINA+KDVAKAL DLISA
Sbjct: 2039 ASTPDKLAQAAQSSAATITQLAEVVKLGAASLGSDDPETQVVLINAIKDVAKALSDLISA 2098
Query: 2098 TKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQEL 2157
TK AA K DDP+++QLK +AKVMVTNVTSLLKTVKAVEDEAT+GTRALEAT E I+QEL
Sbjct: 2099 TKGAASKPVDDPSMYQLKGAAKVMVTNVTSLLKTVKAVEDEATRGTRALEATIECIKQEL 2158
Query: 2158 AVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLR 2217
VF S + P KTS+PE+ IRMTKGITMATAKAVAAGNSCRQEDVIATANLSR+A++DML
Sbjct: 2159 TVFQSKDVPEKTSSPEESIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRKAVSDMLT 2218
Query: 2218 ACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVA 2277
ACK+A++HP+V+ +VR RAL +G EC GYL+LL+HVL+ LQKP+PE KQQL SKRVA
Sbjct: 2219 ACKQASFHPDVSDEVRTRALRFGTECTLGYLDLLEHVLVILQKPTPEFKQQLAAFSKRVA 2278
Query: 2278 GSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADE 2337
G+VTELIQAAEAMKGTEWVDPEDPTVIAE ELLGAAA+IEAAAKKLEQLKPRAKPK+ADE
Sbjct: 2279 GAVTELIQAAEAMKGTEWVDPEDPTVIAETELLGAAASIEAAAKKLEQLKPRAKPKQADE 2338
Query: 2338 SLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAA 2397
+L+FEEQILEAAKSIAAATSALVK+ASAAQRELVAQGKVG+IPANA DDGQWSQGLISAA
Sbjct: 2339 TLDFEEQILEAAKSIAAATSALVKSASAAQRELVAQGKVGSIPANAADDGQWSQGLISAA 2398
Query: 2398 RMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQ 2457
RMVAAAT++LCEAANA+VQGHAS+EKLISSAKQVAASTAQLLVACKVKADQDSEAM+RLQ
Sbjct: 2399 RMVAAATSSLCEAANASVQGHASEEKLISSAKQVAASTAQLLVACKVKADQDSEAMRRLQ 2458
Query: 2458 AAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEE 2517
AAGNAVKRASDNLV+AAQK AAF + +++ VVVK K VGGIAQIIAAQEEML+KERELEE
Sbjct: 2459 AAGNAVKRASDNLVRAAQK-AAFGKADDDDVVVKTKFVGGIAQIIAAQEEMLKKERELEE 2517
Query: 2518 ARKKLAQIRQQQYKFLPSELRDE 2540
ARKKLAQIRQQQYKFLP+ELR++
Sbjct: 2518 ARKKLAQIRQQQYKFLPTELRED 2540
>gi|38045919 huntingtin interacting protein 1 [Homo sapiens]
Length = 1037
Score = 127 bits (319), Expect = 1e-28
Identities = 156/641 (24%), Positives = 260/641 (40%), Gaps = 106/641 (16%)
Query: 1906 AAENEEIGSHIKHRVQELGHGCAALVTKAG--------ALQCSPSDAYTKKELIECARRV 1957
A NE+ S +K + EL A L+ K A Q KKEL + R+
Sbjct: 461 AQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERI 520
Query: 1958 SEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHRE 2017
S++ G R TQ + ++ +A + G+L ET A
Sbjct: 521 SDQ----------GQRKTQEQLEVLESLKQELATSQRELQ-VLQGSL-----ETSAQSEA 564
Query: 2018 GILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQ 2077
L ++ LV AA +E+L+ + T +LA T+
Sbjct: 565 NWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLAS---------------TE 609
Query: 2078 VVLINAVKDVAKALGDLISATKAAAGKVGD------DPAVWQLKNSAKVMVTNVTSLLKT 2131
+ KD K L L+ + KAA + D +P + SA +++ VTS+
Sbjct: 610 ESMCQLAKDQRKML--LVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSC 667
Query: 2132 VKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVA 2191
++ +E + Q LA PED + IT+
Sbjct: 668 IEQLEKSWS--------------QYLAC------------PEDISGLLHSITLL------ 695
Query: 2192 AGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELL 2251
A+L+ AIA C A PE A + YGRE YL L
Sbjct: 696 -------------AHLTSDAIAHGATTCLRAP--PEPADSLTEACKQYGRETL-AYLASL 739
Query: 2252 DHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLG 2311
+ S ++ L+ ++ EL+ +K E D + + E+
Sbjct: 740 EEEGSLENADSTAMRNCLS----KIKAIGEELLPRGLDIKQEELGD------LVDKEMAA 789
Query: 2312 AAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELV 2371
+AAIE A ++E++ +++ + L E+IL S+ A L+ A+ QRE+V
Sbjct: 790 TSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIV 849
Query: 2372 AQGKVGAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQ 2430
G+ A P + +W++GLISA++ V + +AA+ VQG E+L+ + +
Sbjct: 850 ESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHE 909
Query: 2431 VAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVV 2490
+AASTAQL+ A KVKAD+DS + +LQ A V +A+ +V + + E+ +
Sbjct: 910 IAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFS 969
Query: 2491 KEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYK 2531
+ Q + +Q +L E EL++ R+KL ++R++ Y+
Sbjct: 970 SMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYE 1010
Score = 40.0 bits (92), Expect = 0.029
Identities = 47/195 (24%), Positives = 88/195 (45%), Gaps = 24/195 (12%)
Query: 563 GDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSEL 622
GD + + A A+ T ++ + EM L + G L+ + + G + L
Sbjct: 780 GDLVDKEMAATSAAIETATARIEEM---------LSKSRAGDTGVKLEVNERILGCCTSL 830
Query: 623 LRSAQP---ASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAA 679
+++ Q AS + ++ ++++ G AS + + + + L+ +KAV A
Sbjct: 831 MQAIQVLIVASKDLQREIVESGR--GTASPKEFYA-----KNSRWTEGLISASKAVGWGA 883
Query: 680 AALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEA 739
+V A V Q G +++ + + A ST+QLVA +KV A S + QL +A
Sbjct: 884 TVMVDAADLVVQ---GRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLA--QLQQA 938
Query: 740 GRLVAKAVEGCVSAS 754
R V +A G V+++
Sbjct: 939 SRGVNQATAGVVAST 953
>gi|48762942 huntingtin interacting protein-1-related [Homo sapiens]
Length = 1068
Score = 109 bits (272), Expect = 4e-23
Identities = 156/756 (20%), Positives = 295/756 (39%), Gaps = 36/756 (4%)
Query: 1781 EAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDE 1840
E N +A+ E ++ V + EA ED E + + G + L +
Sbjct: 284 EGPPNFLRASALAEHIKPVVVIPEEAPED-----EEPENLIEISTGPPAGEPVVVADLFD 338
Query: 1841 GPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEE-LGPLANQLTSDYGRLASE 1899
G P GS D + + + K ++ + K + + L +Q+ + G L +
Sbjct: 339 QTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ 398
Query: 1900 AKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSE 1959
K A + E ++H + +L G + + A + +
Sbjct: 399 RKQKQKALVDNE---QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHS 455
Query: 1960 KVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGI 2019
++ HV A L N T +T +A + + F + RE + + +
Sbjct: 456 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE-QVKRESELKLEEKSDQL 514
Query: 2020 LKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVV 2079
K L + + A +QE L+ QS +RL D + +L + +
Sbjct: 515 EK----LKRELEAKAGELARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREAD 569
Query: 2080 LINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEA 2139
L+ A V + L + ++ + G+ + S + + L + + A
Sbjct: 570 LLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ-RLLDEQFAVLRGAA 628
Query: 2140 TKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQE 2199
+ L+ + L + C+ P S ++ + + A+ + +
Sbjct: 629 AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 688
Query: 2200 DVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQ 2259
V A S A ++ + P D R + REC LEL+ +
Sbjct: 689 -VAALTRFSHLAADTIINGGATSHLAPTDPAD---RLIDTCRECGARALELMGQLQ---- 740
Query: 2260 KPSPELKQQLTGHSKR--VAGSVTELIQAAEAMKGTEW-VDPEDPTVIAENELLGAAAAI 2316
QQ H + V + ++Q + +K V E+ + + E+ +AAI
Sbjct: 741 ------DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAI 794
Query: 2317 EAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKV 2376
E A +++E + +A+ + L E+IL + + A LV +++ Q+E+V G+
Sbjct: 795 EDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG 854
Query: 2377 GAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAAST 2435
A + +W++GLISA++ V L EAA+ V E+LI + ++AAST
Sbjct: 855 AATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAAST 914
Query: 2436 AQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKE-KM 2494
AQL+ A KVKA++ S + RLQ V + N+V A+ K+ + ++ +T+ +
Sbjct: 915 AQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-ASTKSGQEQIEDRDTMDFSGLSL 973
Query: 2495 VGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQY 2530
+ Q + Q +L E+ LE R +L ++R+Q Y
Sbjct: 974 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 1009
Score = 37.4 bits (85), Expect = 0.19
Identities = 73/376 (19%), Positives = 131/376 (34%), Gaps = 88/376 (23%)
Query: 576 AVTTISSN----LTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASA 631
AV+T+ LT ++ L+AAL + ++ GA S L A
Sbjct: 667 AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIING-----GATSHL------APT 715
Query: 632 EPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALM---------------------- 669
+P L+ G + EL+ Q+ + H Q +L+
Sbjct: 716 DPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVR 775
Query: 670 --QLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAP-- 725
+L V AA + +R ED Q + ++ + ++ L +CT ++
Sbjct: 776 QEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIR 835
Query: 726 --TISSPVCQEQLVEAGRLVA----------KAVEGCVSASQAATEDGQLLRGVGAAATA 773
+S Q+++VE+GR A + EG +SAS+A VG AT
Sbjct: 836 LLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKA----------VGWGATQ 885
Query: 774 VTQALNELLQH--------VKAHATGAGPA-----------------GRYDQATDTILTV 808
+ +A ++++ H V +H A A R + + T+
Sbjct: 886 LVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNER 945
Query: 809 TENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATA 868
N+ +S E + + + L+ K + E + + K L A ++
Sbjct: 946 AANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 1005
Query: 869 KMVEAAKGAAAHPDSE 884
K GA+ P E
Sbjct: 1006 KQHYVLAGASGSPGEE 1021
>gi|239750456 PREDICTED: similar to KIAA0655 protein [Homo sapiens]
Length = 1048
Score = 109 bits (272), Expect = 4e-23
Identities = 156/756 (20%), Positives = 295/756 (39%), Gaps = 36/756 (4%)
Query: 1781 EAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDE 1840
E N +A+ E ++ V + EA ED E + + G + L +
Sbjct: 264 EGPPNFLRASALAEHIKPVVVIPEEAPED-----EEPENLIEISTGPPAGEPVVVADLFD 318
Query: 1841 GPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEE-LGPLANQLTSDYGRLASE 1899
G P GS D + + + K ++ + K + + L +Q+ + G L +
Sbjct: 319 QTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQ 378
Query: 1900 AKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSE 1959
K A + E ++H + +L G + + A + +
Sbjct: 379 RKQKQKALVDNE---QLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHS 435
Query: 1960 KVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGI 2019
++ HV A L N T +T +A + + F + RE + + +
Sbjct: 436 ELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVE-QVKRESELKLEEKSDQL 494
Query: 2020 LKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVV 2079
K L + + A +QE L+ QS +RL D + +L + +
Sbjct: 495 EK----LKRELEAKAGELARAQEALSHTEQSKSELSSRL-DTLSAEKDALSGAVRQREAD 549
Query: 2080 LINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEA 2139
L+ A V + L + ++ + G+ + S + + L + + A
Sbjct: 550 LLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQ-RLLDEQFAVLRGAA 608
Query: 2140 TKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQE 2199
+ L+ + L + C+ P S ++ + + A+ + +
Sbjct: 609 AEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASAL 668
Query: 2200 DVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQ 2259
V A S A ++ + P D R + REC LEL+ +
Sbjct: 669 -VAALTRFSHLAADTIINGGATSHLAPTDPAD---RLIDTCRECGARALELMGQLQ---- 720
Query: 2260 KPSPELKQQLTGHSKR--VAGSVTELIQAAEAMKGTEW-VDPEDPTVIAENELLGAAAAI 2316
QQ H + V + ++Q + +K V E+ + + E+ +AAI
Sbjct: 721 ------DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAI 774
Query: 2317 EAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKV 2376
E A +++E + +A+ + L E+IL + + A LV +++ Q+E+V G+
Sbjct: 775 EDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRG 834
Query: 2377 GAIPANAL-DDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAAST 2435
A + +W++GLISA++ V L EAA+ V E+LI + ++AAST
Sbjct: 835 AATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAAST 894
Query: 2436 AQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKE-KM 2494
AQL+ A KVKA++ S + RLQ V + N+V A+ K+ + ++ +T+ +
Sbjct: 895 AQLVAASKVKANKHSPHLSRLQECSRTVNERAANVV-ASTKSGQEQIEDRDTMDFSGLSL 953
Query: 2495 VGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQY 2530
+ Q + Q +L E+ LE R +L ++R+Q Y
Sbjct: 954 IKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHY 989
Score = 37.4 bits (85), Expect = 0.19
Identities = 73/376 (19%), Positives = 131/376 (34%), Gaps = 88/376 (23%)
Query: 576 AVTTISSN----LTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASA 631
AV+T+ LT ++ L+AAL + ++ GA S L A
Sbjct: 647 AVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIING-----GATSHL------APT 695
Query: 632 EPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALM---------------------- 669
+P L+ G + EL+ Q+ + H Q +L+
Sbjct: 696 DPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVR 755
Query: 670 --QLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAP-- 725
+L V AA + +R ED Q + ++ + ++ L +CT ++
Sbjct: 756 QEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIR 815
Query: 726 --TISSPVCQEQLVEAGRLVA----------KAVEGCVSASQAATEDGQLLRGVGAAATA 773
+S Q+++VE+GR A + EG +SAS+A VG AT
Sbjct: 816 LLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKA----------VGWGATQ 865
Query: 774 VTQALNELLQH--------VKAHATGAGPA-----------------GRYDQATDTILTV 808
+ +A ++++ H V +H A A R + + T+
Sbjct: 866 LVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNER 925
Query: 809 TENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATA 868
N+ +S E + + + L+ K + E + + K L A ++
Sbjct: 926 AANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELR 985
Query: 869 KMVEAAKGAAAHPDSE 884
K GA+ P E
Sbjct: 986 KQHYVLAGASGSPGEE 1001
>gi|13446229 mesoderm development candidate 1 [Homo sapiens]
Length = 362
Score = 101 bits (252), Expect = 8e-21
Identities = 75/294 (25%), Positives = 134/294 (45%), Gaps = 5/294 (1%)
Query: 1336 AAAARAVTDSINQLITMCTQ-QAPGQKECDNALRELETVRELLENPVQP-INDMSYFGCL 1393
+A A + +L+++C + Q D L E L E P S+ C
Sbjct: 20 SAIGGASSQPRKRLVSVCDHCKGKMQLVADLLLLSSEARPVLFEGPASSGAGAESFEQCR 79
Query: 1394 DSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAAAQAAYLVGVSDPN 1453
D+++ +K L + G E GD++ + TE +A AAYL V+ P
Sbjct: 80 DTIIARTKGLSILTHDVQSQLNMGRFGEAGDSLVELGDLVVSLTECSAHAAYLAAVATPG 139
Query: 1454 SQAGQQGLVEPTQFARANQAIQMACQSLGEP---GCTQAQVLSAATIVAKHTSALCNSCR 1510
+Q Q GLV+ + R ++ C L T +L + ++++ L ++C
Sbjct: 140 AQPAQPGLVDRYRVTRCRHEVEQGCAVLRATPLADMTPQLLLEVSQGLSRNLKFLTDACA 199
Query: 1511 LASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATAPLLEAVD 1570
LAS ++ + ++ QF K ++ S + L+ ++ + A +E R++C + PL++AV
Sbjct: 200 LASDKSRDRFSREQFKLGVKCMSTSASALLACVREVKVAPSELARSRCALFSGPLVQAVS 259
Query: 1571 NLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNP 1624
L FA+ P+F A +S EG+A I+ A +++ + L Q R LA +P
Sbjct: 260 ALVGFATEPQFLGRAAAVSAEGKAVQTAILGGAMSVVSACVLLTQCLRDLAQHP 313
>gi|29789006 fermitin family homolog 2 isoform 1 [Homo sapiens]
Length = 680
Score = 69.7 bits (169), Expect = 3e-11
Identities = 40/142 (28%), Positives = 77/142 (54%), Gaps = 6/142 (4%)
Query: 268 KEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVP 327
K+Y ++ +I +AH+N QMS IEAK+R+++ +SL +G++ F+ + +G K
Sbjct: 528 KKYKNKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIA--RFQGGKK--E 583
Query: 328 RLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAAS--PKSFTLDFGDYQDGYYSVQTTEG 385
L+GI ++R+D T + I+ W +N+K+W + K T++F D + +
Sbjct: 584 ELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDC 643
Query: 386 EQIAQLIAGYIDIILKKKKSKD 407
+ + + I GYI + + K +
Sbjct: 644 KVVHEFIGGYIFLSTRAKDQNE 665
Score = 44.7 bits (104), Expect = 0.001
Identities = 27/73 (36%), Positives = 39/73 (53%)
Query: 173 WLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSF 232
WLD R+L EQ V+E+E LLLR K++ D +++N LY QA+ IL +
Sbjct: 252 WLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTE 311
Query: 233 DKACEFAGFQCQI 245
++ FA Q I
Sbjct: 312 EEMMMFAALQYHI 324
>gi|201861813 fermitin family homolog 2 isoform 2 [Homo sapiens]
Length = 687
Score = 68.9 bits (167), Expect = 6e-11
Identities = 42/150 (28%), Positives = 80/150 (53%), Gaps = 8/150 (5%)
Query: 262 LKDFLPKE--YVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKM 319
LK + K+ Y++ +I +AH+N QMS IEAK+R+++ +SL +G++ F+ +
Sbjct: 527 LKKYKNKQPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIA--RF 584
Query: 320 KGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAAS--PKSFTLDFGDYQDGY 377
+G K L+GI ++R+D T + I+ W +N+K+W + K T++F D
Sbjct: 585 QGGKK--EELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLS 642
Query: 378 YSVQTTEGEQIAQLIAGYIDIILKKKKSKD 407
+ + + + + I GYI + + K +
Sbjct: 643 FICTEVDCKVVHEFIGGYIFLSTRAKDQNE 672
Score = 44.7 bits (104), Expect = 0.001
Identities = 27/73 (36%), Positives = 39/73 (53%)
Query: 173 WLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSF 232
WLD R+L EQ V+E+E LLLR K++ D +++N LY QA+ IL +
Sbjct: 252 WLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTE 311
Query: 233 DKACEFAGFQCQI 245
++ FA Q I
Sbjct: 312 EEMMMFAALQYHI 324
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 68.2 bits (165), Expect = 1e-10
Identities = 57/243 (23%), Positives = 113/243 (46%), Gaps = 15/243 (6%)
Query: 173 WLDHGRTLREQGVEEHETLLL--RRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPV 230
WL + + Q V + LL R KF+ D + + + L ++Q ++ ILN
Sbjct: 58 WLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYC 117
Query: 231 SFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQ------KGERKIFQAHK 284
+ A A + Q ++G N++ HK+G+L LP+ ++Q + E +I H+
Sbjct: 118 PPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHE 177
Query: 285 NCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKT 344
M +A + Y+K+A+ L+ YGV++F +K K + L LG+ + D T
Sbjct: 178 EHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGL--NIYEQNDRLT 235
Query: 345 KEVIQEWNLTNIKRWAASPKSFTLDFGDYQDG---YYSVQTTEGEQIAQLIAGYIDIILK 401
++ W + I+ + + K F + D + +Y+ + ++I L G ++ ++
Sbjct: 236 PKIGFPW--SEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMR 293
Query: 402 KKK 404
++K
Sbjct: 294 RRK 296
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 68.2 bits (165), Expect = 1e-10
Identities = 57/244 (23%), Positives = 116/244 (47%), Gaps = 17/244 (6%)
Query: 173 WLDHGRTLREQGVEEHETLLL--RRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPV 230
WL + + +Q V++ L R KFF D + + + L ++Q ++ ILN
Sbjct: 58 WLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYC 117
Query: 231 SFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPK------EYVKQKGERKIFQAHK 284
+ A A + Q ++G +N++ HK G+L LP+ + K++ E +I H+
Sbjct: 118 PPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHE 177
Query: 285 NCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEK- 343
M ++ + Y+K+A+ L+ YGV++F +K K + L LG+ + D+K
Sbjct: 178 EHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLN---IYEHDDKL 234
Query: 344 TKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDG---YYSVQTTEGEQIAQLIAGYIDIIL 400
T ++ W + I+ + + K F + D + +Y+ + ++I L G ++ +
Sbjct: 235 TPKIGFPW--SEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYM 292
Query: 401 KKKK 404
+++K
Sbjct: 293 RRRK 296
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 67.8 bits (164), Expect = 1e-10
Identities = 44/151 (29%), Positives = 76/151 (50%), Gaps = 4/151 (2%)
Query: 169 DELNWLDHGRTLREQGVEEHE-TLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGS 227
D WLD + +R+Q +L R KFF SD N + + ++Q + DIL G
Sbjct: 80 DNPRWLDPNKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQY-FLQIKQDILTGR 138
Query: 228 HPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCG 287
P + A A F Q + G +++ ++ +G+L F+P + Q E++I + H+
Sbjct: 139 LPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ--PQDFEKEIAKLHQQHI 196
Query: 288 QMSEIEAKVRYVKLARSLKTYGVSFFLVKEK 318
+S EA+ Y+ AR+L+ YGV F +++
Sbjct: 197 GLSPAEAEFNYLNTARTLELYGVEFHYARDQ 227
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 65.5 bits (158), Expect = 7e-10
Identities = 56/251 (22%), Positives = 114/251 (45%), Gaps = 21/251 (8%)
Query: 169 DELNWLDHGRTLREQGVEEHE--TLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNG 226
D + WL + + + V + E T KF+ + + + +L ++Q + IL+
Sbjct: 70 DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 227 SHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVK------QKGERKIF 280
+ + A + Q ++G ++ HK GFL ++ LPK + + E +I
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 281 QAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRV 340
+ + EA++ Y+K+A+ L+ YGV++F ++ K K LLG+ +
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNK-----KGTELLLGVDALGLHIY 244
Query: 341 DEK---TKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTE---GEQIAQLIAG 394
D + T ++ WN I+ + S K FT+ D + + +++ + I QL G
Sbjct: 245 DPENRLTPKISFPWN--EIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIG 302
Query: 395 YIDIILKKKKS 405
D+ ++++K+
Sbjct: 303 NHDLFMRRRKA 313
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 65.5 bits (158), Expect = 7e-10
Identities = 56/251 (22%), Positives = 114/251 (45%), Gaps = 21/251 (8%)
Query: 169 DELNWLDHGRTLREQGVEEHE--TLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNG 226
D + WL + + + V + E T KF+ + + + +L ++Q + IL+
Sbjct: 70 DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 227 SHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVK------QKGERKIF 280
+ + A + Q ++G ++ HK GFL ++ LPK + + E +I
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 281 QAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRV 340
+ + EA++ Y+K+A+ L+ YGV++F ++ K K LLG+ +
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNK-----KGTELLLGVDALGLHIY 244
Query: 341 DEK---TKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTE---GEQIAQLIAG 394
D + T ++ WN I+ + S K FT+ D + + +++ + I QL G
Sbjct: 245 DPENRLTPKISFPWN--EIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIG 302
Query: 395 YIDIILKKKKS 405
D+ ++++K+
Sbjct: 303 NHDLFMRRRKA 313
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 65.5 bits (158), Expect = 7e-10
Identities = 56/251 (22%), Positives = 114/251 (45%), Gaps = 21/251 (8%)
Query: 169 DELNWLDHGRTLREQGVEEHE--TLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNG 226
D + WL + + + V + E T KF+ + + + +L ++Q + IL+
Sbjct: 70 DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 227 SHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVK------QKGERKIF 280
+ + A + Q ++G ++ HK GFL ++ LPK + + E +I
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 281 QAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRV 340
+ + EA++ Y+K+A+ L+ YGV++F ++ K K LLG+ +
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNK-----KGTELLLGVDALGLHIY 244
Query: 341 DEK---TKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTE---GEQIAQLIAG 394
D + T ++ WN I+ + S K FT+ D + + +++ + I QL G
Sbjct: 245 DPENRLTPKISFPWN--EIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIG 302
Query: 395 YIDIILKKKKS 405
D+ ++++K+
Sbjct: 303 NHDLFMRRRKA 313
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 65.5 bits (158), Expect = 7e-10
Identities = 56/251 (22%), Positives = 114/251 (45%), Gaps = 21/251 (8%)
Query: 169 DELNWLDHGRTLREQGVEEHE--TLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNG 226
D + WL + + + V + E T KF+ + + + +L ++Q + IL+
Sbjct: 70 DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDE 129
Query: 227 SHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVK------QKGERKIF 280
+ + A + Q ++G ++ HK GFL ++ LPK + + E +I
Sbjct: 130 KIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERIT 189
Query: 281 QAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRV 340
+ + EA++ Y+K+A+ L+ YGV++F ++ K K LLG+ +
Sbjct: 190 AWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNK-----KGTELLLGVDALGLHIY 244
Query: 341 DEK---TKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTE---GEQIAQLIAG 394
D + T ++ WN I+ + S K FT+ D + + +++ + I QL G
Sbjct: 245 DPENRLTPKISFPWN--EIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIG 302
Query: 395 YIDIILKKKKS 405
D+ ++++K+
Sbjct: 303 NHDLFMRRRKA 313
>gi|116686114 kindlin-1 [Homo sapiens]
Length = 677
Score = 63.9 bits (154), Expect = 2e-09
Identities = 35/142 (24%), Positives = 76/142 (53%), Gaps = 6/142 (4%)
Query: 268 KEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVP 327
K + ++ +I +AH+N QM +EAK+R+++ +SL +G++++LV + KG K
Sbjct: 525 KRHKSKQLAARILEAHQNVAQMPLVEAKLRFIQAWQSLPEFGLTYYLV--RFKGSKK--D 580
Query: 328 RLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAAS--PKSFTLDFGDYQDGYYSVQTTEG 385
+LG++ ++++D T + W TNIK+W + + ++F ++ + +
Sbjct: 581 DILGVSYNRLIKIDAATGIPVTTWRFTNIKQWNVNWETRQVVIEFDQNVFTAFTCLSADC 640
Query: 386 EQIAQLIAGYIDIILKKKKSKD 407
+ + + I GYI + + K +
Sbjct: 641 KIVHEYIGGYIFLSTRSKDQNE 662
Score = 47.4 bits (111), Expect = 2e-04
Identities = 29/73 (39%), Positives = 39/73 (53%)
Query: 173 WLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSF 232
WLD R+L EQG++E E LLLR K++ D V++N LY QAR IL +
Sbjct: 250 WLDSSRSLMEQGIQEDEQLLLRFKYYSFFDLNPKYDAVRINQLYEQARWAILLEEIDCTE 309
Query: 233 DKACEFAGFQCQI 245
++ FA Q I
Sbjct: 310 EEMLIFAALQYHI 322
>gi|28626504 fermitin family homolog 3 short form [Homo sapiens]
Length = 663
Score = 63.9 bits (154), Expect = 2e-09
Identities = 44/180 (24%), Positives = 89/180 (49%), Gaps = 23/180 (12%)
Query: 226 GSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKN 285
G+HP D + E G P ++K KA K P+ I +AH+N
Sbjct: 484 GNHPHGPDASAE--GLNPYGLVAPRFQRKFKA-----KQLTPR----------ILEAHQN 526
Query: 286 CGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTK 345
Q+S EA++R+++ +SL +G+S+ +V + KG K +LGI ++R+D
Sbjct: 527 VAQLSLAEAQLRFIQAWQSLPDFGISYVMV--RFKGSRK--DEILGIANNRLIRIDLAVG 582
Query: 346 EVIQEWNLTNIKRWAAS--PKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKK 403
+V++ W +N+++W + + ++F ++ + +S + + + I GYI + +++
Sbjct: 583 DVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRER 642
Score = 46.6 bits (109), Expect = 3e-04
Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 50/238 (21%)
Query: 55 DPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMT 114
+ K+ L+ LD Y + + + + RP+ +R+ + + S+ + +
Sbjct: 67 EQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQAVAA 126
Query: 115 ICARIGITNHDEYSLVR--ELMEEKKEE--------------ITGTLRK----------- 147
IC + I + +E SL+R E E+KK+E + G +
Sbjct: 127 ICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEELYDLSKVVLAGGVAPALFRGMPAHFS 186
Query: 148 -------------------DKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEH 188
D LL+ + L K T WLD R L +QG++
Sbjct: 187 DSAQTEACYHMLSRPQPPPDPLLLQRLPRPSSLSDK--TQLHSRWLDSSRCLMQQGIKAG 244
Query: 189 ETLLLRRKFFYSDQNVDSR-DPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQI 245
+ L LR K +YS ++D + DPV+L LY QAR D+L + ++ FA Q I
Sbjct: 245 DALWLRFK-YYSFFDLDPKTDPVRLTQLYEQARWDLLLEEIDCTEEEMMVFAALQYHI 301
>gi|41281905 fermitin family homolog 3 long form [Homo sapiens]
Length = 667
Score = 63.9 bits (154), Expect = 2e-09
Identities = 44/180 (24%), Positives = 89/180 (49%), Gaps = 23/180 (12%)
Query: 226 GSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKN 285
G+HP D + E G P ++K KA K P+ I +AH+N
Sbjct: 488 GNHPHGPDASAE--GLNPYGLVAPRFQRKFKA-----KQLTPR----------ILEAHQN 530
Query: 286 CGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTK 345
Q+S EA++R+++ +SL +G+S+ +V + KG K +LGI ++R+D
Sbjct: 531 VAQLSLAEAQLRFIQAWQSLPDFGISYVMV--RFKGSRK--DEILGIANNRLIRIDLAVG 586
Query: 346 EVIQEWNLTNIKRWAAS--PKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKK 403
+V++ W +N+++W + + ++F ++ + +S + + + I GYI + +++
Sbjct: 587 DVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRER 646
Score = 46.6 bits (109), Expect = 3e-04
Identities = 57/238 (23%), Positives = 95/238 (39%), Gaps = 50/238 (21%)
Query: 55 DPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMT 114
+ K+ L+ LD Y + + + + RP+ +R+ + + S+ + +
Sbjct: 67 EQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRALRLRASFSQPLFQAVAA 126
Query: 115 ICARIGITNHDEYSLVR--ELMEEKKEE--------------ITGTLRK----------- 147
IC + I + +E SL+R E E+KK+E + G +
Sbjct: 127 ICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEELYDLSKVVLAGGVAPALFRGMPAHFS 186
Query: 148 -------------------DKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEH 188
D LL+ + L K T WLD R L +QG++
Sbjct: 187 DSAQTEACYHMLSRPQPPPDPLLLQRLPRPSSLSDK--TQLHSRWLDSSRCLMQQGIKAG 244
Query: 189 ETLLLRRKFFYSDQNVDSR-DPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQI 245
+ L LR K +YS ++D + DPV+L LY QAR D+L + ++ FA Q I
Sbjct: 245 DALWLRFK-YYSFFDLDPKTDPVRLTQLYEQARWDLLLEEIDCTEEEMMVFAALQYHI 301
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 62.8 bits (151), Expect = 4e-09
Identities = 54/243 (22%), Positives = 111/243 (45%), Gaps = 15/243 (6%)
Query: 173 WLDHGRTLREQGVEEHETLLL--RRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPV 230
WL + + Q V + L R KF+ D + + L ++Q ++ IL+
Sbjct: 58 WLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYC 117
Query: 231 SFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQ------KGERKIFQAHK 284
+ A + Q +FG +N++ HK+G+L + +P+ + Q + E +I H
Sbjct: 118 PPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHA 177
Query: 285 NCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKT 344
M + A + Y+K+A+ L+ YG+++F +K K L LG+ + D+ T
Sbjct: 178 EHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGL--NIYEKDDKLT 235
Query: 345 KEVIQEWNLTNIKRWAASPKSFTLDFGDYQDG---YYSVQTTEGEQIAQLIAGYIDIILK 401
++ W + I+ + + K F + D + +Y+ + ++I QL G ++ ++
Sbjct: 236 PKIGFPW--SEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMR 293
Query: 402 KKK 404
++K
Sbjct: 294 RRK 296
Score = 33.9 bits (76), Expect = 2.1
Identities = 41/171 (23%), Positives = 65/171 (38%), Gaps = 9/171 (5%)
Query: 2306 ENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASA 2365
E + + A A E K+LE+ + + K + +EQ++ + + +
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 2366 AQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLI 2425
A+REL Q + Q + A RM A E AV SQE+L
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKE--ELERQAVDQIKSQEQLA 418
Query: 2426 SSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQK 2476
+ + A A L A + K D+ E R K A D+LVK ++
Sbjct: 419 AELAEYTAKIALLEEARRRKEDEVEEWQHR-------AKEAQDDLVKTKEE 462
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 62.8 bits (151), Expect = 4e-09
Identities = 54/243 (22%), Positives = 111/243 (45%), Gaps = 15/243 (6%)
Query: 173 WLDHGRTLREQGVEEHETLLL--RRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPV 230
WL + + Q V + L R KF+ D + + L ++Q ++ IL+
Sbjct: 58 WLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYC 117
Query: 231 SFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQ------KGERKIFQAHK 284
+ A + Q +FG +N++ HK+G+L + +P+ + Q + E +I H
Sbjct: 118 PPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHA 177
Query: 285 NCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKT 344
M + A + Y+K+A+ L+ YG+++F +K K L LG+ + D+ T
Sbjct: 178 EHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGL--NIYEKDDKLT 235
Query: 345 KEVIQEWNLTNIKRWAASPKSFTLDFGDYQDG---YYSVQTTEGEQIAQLIAGYIDIILK 401
++ W + I+ + + K F + D + +Y+ + ++I QL G ++ ++
Sbjct: 236 PKIGFPW--SEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMR 293
Query: 402 KKK 404
++K
Sbjct: 294 RRK 296
Score = 33.9 bits (76), Expect = 2.1
Identities = 41/171 (23%), Positives = 65/171 (38%), Gaps = 9/171 (5%)
Query: 2306 ENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASA 2365
E + + A A E K+LE+ + + K + +EQ++ + + +
Sbjct: 301 EVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKK 360
Query: 2366 AQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLI 2425
A+REL Q + Q + A RM A E AV SQE+L
Sbjct: 361 AERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKE--ELERQAVDQIKSQEQLA 418
Query: 2426 SSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQK 2476
+ + A A L A + K D+ E R K A D+LVK ++
Sbjct: 419 AELAEYTAKIALLEEARRRKEDEVEEWQHR-------AKEAQDDLVKTKEE 462
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 62.8 bits (151), Expect = 4e-09
Identities = 53/232 (22%), Positives = 106/232 (45%), Gaps = 19/232 (8%)
Query: 186 EEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQI 245
EE T KF+ + + + +L ++Q + IL+ + + A + Q
Sbjct: 47 EEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQA 106
Query: 246 QFGPHNEQKHKAGFLDLKDFLPKEYVK------QKGERKIFQAHKNCGQMSEIEAKVRYV 299
++G ++ HK GFL ++ LPK + + E +I + + EA++ Y+
Sbjct: 107 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYL 166
Query: 300 KLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEK---TKEVIQEWNLTNI 356
K+A+ L+ YGV++F ++ K K LLG+ + D + T ++ WN I
Sbjct: 167 KIAQDLEMYGVNYFAIRNK-----KGTELLLGVDALGLHIYDPENRLTPKISFPWN--EI 219
Query: 357 KRWAASPKSFTLDFGDYQDGYYSVQTTE---GEQIAQLIAGYIDIILKKKKS 405
+ + S K FT+ D + + +++ + I QL G D+ ++++K+
Sbjct: 220 RNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKA 271
>gi|201861823 fermitin family homolog 2 isoform 3 [Homo sapiens]
Length = 633
Score = 62.4 bits (150), Expect = 6e-09
Identities = 33/100 (33%), Positives = 60/100 (60%), Gaps = 6/100 (6%)
Query: 262 LKDFLPKE--YVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKM 319
LK + K+ Y++ +I +AH+N QMS IEAK+R+++ +SL +G++ F+ +
Sbjct: 527 LKKYKNKQPGYIRDLITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIA--RF 584
Query: 320 KGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRW 359
+G K L+GI ++R+D T + I+ W +N+K+W
Sbjct: 585 QGGKK--EELIGIAYNRLIRMDASTGDAIKTWRFSNMKQW 622
Score = 44.7 bits (104), Expect = 0.001
Identities = 27/73 (36%), Positives = 39/73 (53%)
Query: 173 WLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSF 232
WLD R+L EQ V+E+E LLLR K++ D +++N LY QA+ IL +
Sbjct: 252 WLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWAILLEEIECTE 311
Query: 233 DKACEFAGFQCQI 245
++ FA Q I
Sbjct: 312 EEMMMFAALQYHI 324
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 62.0 bits (149), Expect = 7e-09
Identities = 41/154 (26%), Positives = 72/154 (46%), Gaps = 7/154 (4%)
Query: 173 WLDHGRTLREQ----GVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSH 228
WLD +TL E TL KF Y++ ++ + ++Q + D+L G
Sbjct: 70 WLDPAKTLAEHKELINTGPPYTLYFGIKF-YAEDPCKLKEEITRYQFFLQVKQDVLQGRL 128
Query: 229 PVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQ 288
P + A + + Q + G ++ KH AG++ F+P + K++ E I + HK
Sbjct: 129 PCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQ--KEELEEAIERIHKTLMG 186
Query: 289 MSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGK 322
EA++ Y++ A+SL+ YGV V + K +
Sbjct: 187 QIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSE 220
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 60.1 bits (144), Expect = 3e-08
Identities = 53/225 (23%), Positives = 89/225 (39%), Gaps = 42/225 (18%)
Query: 90 IRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDK 149
I LDG V+T V T +L + +G+T + + L
Sbjct: 33 IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQ------------------- 73
Query: 150 TLLRDEKKMEKLKQKLHTDDELN---WLDHGRTLREQGVEEHE-TLLLRRKFFYSDQNVD 205
H DD ++ WL+ + +R+Q TL R +FF D N
Sbjct: 74 ----------------HDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTL 117
Query: 206 SRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDF 265
++ + +L ++Q + DI G + A A + Q FG +N H G+L F
Sbjct: 118 QQEQTR-HLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHF 176
Query: 266 LPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGV 310
+P + + K+ H+ + + EA+ Y+ +AR+L YGV
Sbjct: 177 IPDQ--NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGV 219
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 60.1 bits (144), Expect = 3e-08
Identities = 53/225 (23%), Positives = 89/225 (39%), Gaps = 42/225 (18%)
Query: 90 IRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDK 149
I LDG V+T V T +L + +G+T + + L
Sbjct: 33 IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQ------------------- 73
Query: 150 TLLRDEKKMEKLKQKLHTDDELN---WLDHGRTLREQGVEEHE-TLLLRRKFFYSDQNVD 205
H DD ++ WL+ + +R+Q TL R +FF D N
Sbjct: 74 ----------------HDDDSVDSPRWLEASKAIRKQLKGGFPCTLHFRVRFFIPDPNTL 117
Query: 206 SRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDF 265
++ + +L ++Q + DI G + A A + Q FG +N H G+L F
Sbjct: 118 QQEQTR-HLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHF 176
Query: 266 LPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGV 310
+P + + K+ H+ + + EA+ Y+ +AR+L YGV
Sbjct: 177 IPDQ--NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGV 219
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 60.1 bits (144), Expect = 3e-08
Identities = 52/200 (26%), Positives = 91/200 (45%), Gaps = 20/200 (10%)
Query: 172 NWLDHGRTLREQ-GVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPV 230
+WLD +++++Q + L LR KF+ S+ N + R+ + L +Q + DIL+G
Sbjct: 96 HWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPN-NLREELTRYLFVLQLKQDILSGKLDC 154
Query: 231 SFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMS 290
FD A + A + Q + G ++ +H + F+P + ++ E IF+ K +
Sbjct: 155 PFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQ--TEEMELAIFEKWKEYRGQT 212
Query: 291 EIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQE 350
+A+ Y+ A+ L+ YGV +VK + LG+T V+ + TK +
Sbjct: 213 PAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYS-----LGLTPTGVLVFEGDTKIGLFF 267
Query: 351 WNLTNIKRWAASPKSFTLDF 370
W PK LDF
Sbjct: 268 W-----------PKITRLDF 276
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 59.7 bits (143), Expect = 4e-08
Identities = 170/787 (21%), Positives = 300/787 (38%), Gaps = 114/787 (14%)
Query: 567 ETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSA 626
E + A A + E +R ++ L+ LE+ GG+ + + + L R
Sbjct: 1168 EEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRREL 1227
Query: 627 QPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAAAALVLKA 686
+ A+ + + + EL +Q+ D+L ++ + + + L ++
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQV----------DSLQRVRQKLEKEKSELRMEV 1277
Query: 687 KSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEA----GRL 742
+A E T+ A+A + + ++ K+ + Q QL +A GRL
Sbjct: 1278 DDLAANVE---TLTRAKASAEKLCRTYEDQLSEAKIKVEEL-----QRQLADASTQRGRL 1329
Query: 743 VAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQAT 802
++ E + QL RG AA ++ + +L + KA + A
Sbjct: 1330 QTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDC 1389
Query: 803 DTILTVTENIFSSMGDAGEMVRQARILAQATSDLV---NAIKADAEGESDLENSRKLLSA 859
D + E +A R+L++A +++ + +ADA ++ + +L A
Sbjct: 1390 DLLREQHEE------EAEAQAELQRLLSKANAEVAQWRSKYEADA-----IQRTEELEEA 1438
Query: 860 AKILADATAKMVEAAKGAAAHPDS-EEQQQRLREAAEG----LRMATNAAAQNAIKKKLV 914
K LA + E + A A S E+ + RL+ +E L AT+AAA K++ +
Sbjct: 1439 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1498
Query: 915 QRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQ 974
+R ++ + + AAQ + + L + E + L + + Q
Sbjct: 1499 ERALEERRRQEEEMQRELEAAQRES---RGLGTELFRLRHGHEEALEALETLKRENKNLQ 1555
Query: 975 AQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAEL 1034
+ + Q++L GK S +L + K L +E+
Sbjct: 1556 EEISDLTDQVSL----------SGK----------------SIQELEKTKKALEGEKSEI 1589
Query: 1035 RTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKCTQDLGNS 1094
+ A ++A+ G LE++ ++ ++ +L +VKA D KL E E+C N
Sbjct: 1590 QAALEEAE---GALELEETKTL--RIQLELSQVKAEV-DRKL----AEKDEECANLRRNH 1639
Query: 1095 TKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDT 1154
+AV S A L E NE A + + G L L L A +
Sbjct: 1640 QRAVESLQASLDAETRARNE--ALRLKKKMEGDLNDL--------ELQLGHATRQATEAQ 1689
Query: 1155 ASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALR 1214
A+ L +A E+A + + +QRLA QAL R S L + + A
Sbjct: 1690 AATRLMQAQLKEEQAGR--------DEEQRLAAELHEQAQALERRASLLAAELEELRAAL 1741
Query: 1215 AVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRF 1274
G+ S+RL L EA RLN L+ T L+ + DLA+ SG
Sbjct: 1742 EQGERSRRLAEQEL-------LEATERLNL----LHSQNTGLLNQKKKLEADLAQLSGEV 1790
Query: 1275 GQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQ 1334
+ EA E A +A + D A + LK +S+ L K L + L+++
Sbjct: 1791 EEAAQERREA-EEKAKKAIT--DAAMMAEELKKEQDTSAHLERMKKTL--EQTVRELQAR 1845
Query: 1335 LAAAARA 1341
L A +A
Sbjct: 1846 LEEAEQA 1852
Score = 58.2 bits (139), Expect = 1e-07
Identities = 192/920 (20%), Positives = 344/920 (37%), Gaps = 130/920 (14%)
Query: 1658 QLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLA 1717
+++ E + L+ L D ++ V+ LA R + L + ++I L LA
Sbjct: 961 KVQLEGKVKELSERLEDEEE-----VNADLAAR----RRKLEDECTELKKDIDDLKLTLA 1011
Query: 1718 NAARAEASQLGHKVSQMAQYFEPL--TLAAVGAASKTLSHPQQMAL------LDQTKTLA 1769
A + E +KV + + L ++A + K L Q AL D+ L
Sbjct: 1012 KAEK-EKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSALT 1070
Query: 1770 ESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVD 1829
++ L+L ++ + +Q + E A + + DL T A AA
Sbjct: 1071 KAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEG---DLKLTQESVADAA-------- 1119
Query: 1830 SITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQL 1889
Q QL+E + + S + + V + + +Q+ + + EEL +L
Sbjct: 1120 ---QDKQQLEEKL--KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEEL---EEEL 1171
Query: 1890 TSDYGRLASEAKPAAVAAENEEIGSHIKHRVQELG-------HGCAALVTKAGALQCSPS 1942
++ A K A AA E + R++E G GC + G L+
Sbjct: 1172 EAERAARARVEKQRAEAARELE---ELSERLEEAGGASAGQREGCRKREAELGRLRRELE 1228
Query: 1943 DAYTKKELIECA--RRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFAT 2000
+A + E A R+ +E + + + + R Q S + + DL + T
Sbjct: 1229 EAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLT 1288
Query: 2001 AGTLNREGT-ETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKL-------AQAAQSSV 2052
+ E T+ D L AK+ VE+ + + +A+ + +L ++ +
Sbjct: 1289 RAKASAEKLCRTYEDQ----LSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE 1344
Query: 2053 ATITRLADVVKLGAASLGA------EDPETQVVLINAVK--------------DVAKALG 2092
I++L+ L A SL E+ + + L +AV+ + A+A
Sbjct: 1345 CLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQA 1404
Query: 2093 DLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEH 2152
+L + K + A W+ K A ++ + +E+ K L+ E
Sbjct: 1405 EL----QRLLSKANAEVAQWRSKYEADA--------IQRTEELEEAKKKLALRLQEAEEG 1452
Query: 2153 IRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAI 2212
+ A CS AK + +T + AT+ A A R + A RR
Sbjct: 1453 VEAANAK-CSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRH---LERALEERRRQ 1508
Query: 2213 ADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGH 2272
+ ++ EAA L L +G E A LE L LQ+ +L Q++
Sbjct: 1509 EEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLS 1568
Query: 2273 SKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLE----QLKP 2328
K S+ EL + +A++G + E + E E GA E +++ Q+K
Sbjct: 1569 GK----SIQELEKTKKALEGEK---SEIQAALEEAE--GALELEETKTLRIQLELSQVKA 1619
Query: 2329 RAKPKEAD---ESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALD 2385
K A+ E N A +S+ A+ A +A + A R + L+
Sbjct: 1620 EVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALR-------LKKKMEGDLN 1672
Query: 2386 DGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVK 2445
D + G + A A L +A Q +E+ ++AA + A + +
Sbjct: 1673 DLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ------RLAAELHEQAQALERR 1726
Query: 2446 ADQDSEAMKRLQAA---GNAVKR-ASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQI 2501
A + ++ L+AA G +R A L++A ++ Q + K+K+ +AQ+
Sbjct: 1727 ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQL 1786
Query: 2502 IAAQEEMLRKERELEEARKK 2521
EE ++ RE EE KK
Sbjct: 1787 SGEVEEAAQERREAEEKAKK 1806
Score = 38.1 bits (87), Expect = 0.11
Identities = 137/735 (18%), Positives = 268/735 (36%), Gaps = 103/735 (14%)
Query: 522 LGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAG------------------ 563
LG+ S + K+++ K E+ +VD + A ++ A
Sbjct: 1252 LGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIK 1311
Query: 564 ---------------DPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPL 608
+T+ + + ++++SRG L A LE+
Sbjct: 1312 VEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEE 1371
Query: 609 LQAAKGLAGAVS------ELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDP 662
+A LA AV +LLR AE + L + + +A+ E+ Q + + D
Sbjct: 1372 SKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRL---LSKANAEVAQWRSKYEAD- 1427
Query: 663 HFQDALMQLAKAVASAAAALVLKAKSVAQRTED-----SGLQTQVIAAATQCALSTSQLV 717
+Q + + A L L+ + + E S L+ + T+ T +L
Sbjct: 1428 -----AIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELE 1482
Query: 718 ACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQA 777
T A E+ +E R + ++ + A+Q + RG+G +
Sbjct: 1483 RATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRES------RGLGTELFRLRHG 1536
Query: 778 LNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLV 837
E L+ ++ + I +T+ + S E+ + + L S++
Sbjct: 1537 HEEALEALETLKR------ENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQ 1590
Query: 838 NAIKADAEGESDLENSRKL---LSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAA 894
A++ +AEG +LE ++ L L +++ A+ K+ E + A + QR E+
Sbjct: 1591 AALE-EAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECA---NLRRNHQRAVESL 1646
Query: 895 EGLRMATNAAAQNAIKKK---------LVQRLEHAAKQA--AASATQTIAA---AQHAAS 940
+ A A A++ K L +L HA +QA A +AT+ + A + A
Sbjct: 1647 QASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGR 1706
Query: 941 TPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKM 1000
+ + L + +A+ + LL + +A + L A Q L+ ++
Sbjct: 1707 DEEQRLAAE--LHEQAQALERRASLLAAELEELRAALEQGERSRRL--AEQELLEATERL 1762
Query: 1001 VAAAKASVPTI-QDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQN 1059
+ + Q + L+Q + + A E R A +KA++A + A + +
Sbjct: 1763 NLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKA-----ITDAAMMAEE 1817
Query: 1060 LEKDLQEVKAAARDGKLKPLPGETMEKCTQDLGNSTKAV---SSAIAQLLGEVAQGNENY 1116
L+K E +A ++K +T+ + L + +A Q L + E
Sbjct: 1818 LKK---EQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAE 1874
Query: 1117 AGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHP 1176
+ A L+ + + R V L L D++DK S ++ K+
Sbjct: 1875 LDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQF-EE 1933
Query: 1177 GDPESQQRLAQVAKA 1191
+ ++ LA+ KA
Sbjct: 1934 AEQQANTNLAKYRKA 1948
Score = 37.4 bits (85), Expect = 0.19
Identities = 130/605 (21%), Positives = 222/605 (36%), Gaps = 91/605 (15%)
Query: 1958 SEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTE----TFA 2013
S + LAAL+A RG + + AA A + + +I + E A
Sbjct: 891 SAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADA 950
Query: 2014 DHREGILKTAKVLVED-TKVLVQNAAGSQEKLAQAA------QSSVATITRLADVVKLGA 2066
+ R +L +KV +E K L + +E A A + + + D +KL
Sbjct: 951 EERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTL 1010
Query: 2067 ASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVT 2126
A E T+ N VK++ + + L D +V +L K +
Sbjct: 1011 AKAEKEKQATE----NKVKNLTEEMAAL-------------DESVARLTKEKKALQEAHQ 1053
Query: 2127 SLLKTVKAVEDEATKGTRA---LEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGIT 2183
L ++A ED + T+A LE E + CS E K +RM
Sbjct: 1054 QALGDLQAEEDRVSALTKAKLRLEQQVEDLE------CSLEQEKK-------LRMDT--- 1097
Query: 2184 MATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGREC 2243
AK G+ ++ +A A ++ + + L+ D L L E
Sbjct: 1098 -ERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKK-----------KDSELSQLSLRVED 1145
Query: 2244 ANGYLELLDHVLLTLQKPSPELKQQLTGH-------SKRVAGSVTELIQAAEAMK--GTE 2294
+ + LQ + EL+++L K+ A + EL + +E ++ G
Sbjct: 1146 EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGA 1205
Query: 2295 WVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAA 2354
+ E EL +E AA + E + K+A+ + EQ+ S+
Sbjct: 1206 SAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQV----DSLQR 1261
Query: 2355 ATSALVKAAS---------AAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATN 2405
L K S AA E + + K A + Q S+ I + +
Sbjct: 1262 VRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 1321
Query: 2406 NLCEAANAAVQ-GHASQ-----EKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAA 2459
+ + G S+ E LIS + A AQ L + + +++S+A L A
Sbjct: 1322 ASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHA 1381
Query: 2460 GNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQE-EMLRKERELEEA 2518
A++ D L + ++ A E + E + K +AQ + E + +++ ELEEA
Sbjct: 1382 VQALRHDCDLLREQHEEEA---EAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEA 1438
Query: 2519 RKKLA 2523
+KKLA
Sbjct: 1439 KKKLA 1443
Score = 35.4 bits (80), Expect = 0.72
Identities = 62/298 (20%), Positives = 119/298 (39%), Gaps = 35/298 (11%)
Query: 2258 LQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTV------IAENELLG 2311
L+ + K++L G K SV + Q + ++ E + +D + + + +LLG
Sbjct: 1093 LRMDTERAKRKLEGDLKLTQESVADAAQDKQQLE--EKLKKKDSELSQLSLRVEDEQLLG 1150
Query: 2312 AAAAIEAAAKKLEQLKPRAKPKEAD------ESLNFEEQILEAAKSIAAATSALVKA--A 2363
A KK+++L+ RA+ E + E+Q EAA+ + + L +A A
Sbjct: 1151 AQMQ-----KKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGA 1205
Query: 2364 SAAQRE--LVAQGKVGAIPANALDDGQWSQGLISAARMVAA-ATNNLCEAANAAVQGHAS 2420
SA QRE + ++G + + + ++A R A L E ++ +
Sbjct: 1206 SAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQK 1265
Query: 2421 QEK-----------LISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDN 2469
EK L ++ + + + A C+ DQ SEA +++ + AS
Sbjct: 1266 LEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQ 1325
Query: 2470 LVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQ 2527
+ ++ E + ++ G A + EE+ R+ E +A+ LA Q
Sbjct: 1326 RGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQ 1383
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 59.7 bits (143), Expect = 4e-08
Identities = 42/154 (27%), Positives = 70/154 (45%), Gaps = 2/154 (1%)
Query: 163 QKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDD 222
Q L + +WLDH + +++Q L R +YS + + R+ L +Q R D
Sbjct: 129 QFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHD 188
Query: 223 ILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQA 282
IL+G ++ A E A Q + G +H + F+P + + E IFQ
Sbjct: 189 ILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQ--TEAMEFDIFQR 246
Query: 283 HKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVK 316
K C S +A++ Y+ A+ L+ YGV +V+
Sbjct: 247 WKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVR 280
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 59.7 bits (143), Expect = 4e-08
Identities = 42/154 (27%), Positives = 70/154 (45%), Gaps = 2/154 (1%)
Query: 163 QKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDD 222
Q L + +WLDH + +++Q L R +YS + + R+ L +Q R D
Sbjct: 129 QFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHD 188
Query: 223 ILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQA 282
IL+G ++ A E A Q + G +H + F+P + + E IFQ
Sbjct: 189 ILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQ--TEAMEFDIFQR 246
Query: 283 HKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVK 316
K C S +A++ Y+ A+ L+ YGV +V+
Sbjct: 247 WKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVR 280
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 57.4 bits (137), Expect = 2e-07
Identities = 64/315 (20%), Positives = 129/315 (40%), Gaps = 35/315 (11%)
Query: 85 QRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGT 144
+R + I +L+G + D D+ + A IG+ H ++L T
Sbjct: 571 RRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALA-------------T 617
Query: 145 LRKDKTLLRD-EKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQN 203
L+ ++ D + K+ K+ + W + + + V + TL R KFF D +
Sbjct: 618 LKDNEYFFVDPDLKLTKVAPE-------GWKEEPKKKTKATV--NFTLFFRIKFFMDDVS 668
Query: 204 VDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLK 263
+ + + + Y+Q R DIL + + A Q ++G + + H + ++
Sbjct: 669 L-IQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRME 727
Query: 264 DFLPKEYVKQKG----ERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKM 319
+LP +++ + ++ + H SE E ++ ++K+ + L YGV F V +
Sbjct: 728 HYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEK 787
Query: 320 KGKNKLVPRLLGITKE--CVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGY 377
K + + LLG+ + V V + ++ + K+ + S K TL + DG
Sbjct: 788 KSQTGI---LLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQ--NTSDGI 842
Query: 378 YSVQTTEGEQIAQLI 392
T+ +I Q +
Sbjct: 843 KHGFQTDNSKICQYL 857
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.125 0.338
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,009,635
Number of Sequences: 37866
Number of extensions: 3389913
Number of successful extensions: 13129
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 236
Number of HSP's that attempted gapping in prelim test: 11956
Number of HSP's gapped (non-prelim): 1229
length of query: 2541
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2422
effective length of database: 13,741,464
effective search space: 33281825808
effective search space used: 33281825808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.