Guide to the Human Genome
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Search of human proteins with 222537754

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222537754 hypothetical protein LOC375337 [Homo sapiens]
         (1692 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222537754 hypothetical protein LOC375337 [Homo sapiens]           3381   0.0  
gi|211059431 RANBP2-like and GRIP domain containing 4 [Homo sapi...    47   2e-04
gi|147903302 MAP7 domain containing 3 [Homo sapiens]                   47   2e-04
gi|150418007 RAN binding protein 2 [Homo sapiens]                      45   6e-04
gi|157266273 RANBP2-like and GRIP domain containing 1 [Homo sapi...    43   0.002
gi|118200331 RANBP2-like and GRIP domain containing 2 [Homo sapi...    43   0.002
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]         43   0.002
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]         43   0.002
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo...    43   0.003
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo...    43   0.003
gi|58530840 desmoplakin isoform I [Homo sapiens]                       42   0.007
gi|55770834 centromere protein F [Homo sapiens]                        40   0.015
gi|38044112 restin isoform b [Homo sapiens]                            39   0.033
gi|4506751 restin isoform a [Homo sapiens]                             39   0.033
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    39   0.033
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    39   0.043
gi|58535453 CDK5 regulatory subunit associated protein 2 isoform...    39   0.056
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform...    39   0.056
gi|45505178 cancer antigen 1 [Homo sapiens]                            39   0.056
gi|156139122 CXXC finger 6 [Homo sapiens]                              38   0.073
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 38   0.073
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    38   0.095
gi|38788333 remodeling and spacing factor 1 [Homo sapiens]             37   0.12 
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             37   0.12 
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]    37   0.12 
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    37   0.12 
gi|45439327 periplakin [Homo sapiens]                                  37   0.12 
gi|221219020 NYD-SP11 protein [Homo sapiens]                           37   0.16 
gi|169214154 PREDICTED: hypothetical protein [Homo sapiens]            37   0.16 
gi|169213511 PREDICTED: hypothetical protein [Homo sapiens]            37   0.16 

>gi|222537754 hypothetical protein LOC375337 [Homo sapiens]
          Length = 1692

 Score = 3381 bits (8767), Expect = 0.0
 Identities = 1692/1692 (100%), Positives = 1692/1692 (100%)

Query: 1    MRRPPPLGPTTASGPEGNVRNLQKRQAPGPGAAGGCGPEAGGCRENKQKRRMVARATPGR 60
            MRRPPPLGPTTASGPEGNVRNLQKRQAPGPGAAGGCGPEAGGCRENKQKRRMVARATPGR
Sbjct: 1    MRRPPPLGPTTASGPEGNVRNLQKRQAPGPGAAGGCGPEAGGCRENKQKRRMVARATPGR 60

Query: 61   GEVESDKSVAASGAGKAARRQVEGRRGPVSPSDSSDPRGLEAAKEAELPLQTERHTKEKR 120
            GEVESDKSVAASGAGKAARRQVEGRRGPVSPSDSSDPRGLEAAKEAELPLQTERHTKEKR
Sbjct: 61   GEVESDKSVAASGAGKAARRQVEGRRGPVSPSDSSDPRGLEAAKEAELPLQTERHTKEKR 120

Query: 121  KVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQSLGKESIIEGIKRRIRNKKLKSLEN 180
            KVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQSLGKESIIEGIKRRIRNKKLKSLEN
Sbjct: 121  KVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQSLGKESIIEGIKRRIRNKKLKSLEN 180

Query: 181  PPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCND 240
            PPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCND
Sbjct: 181  PPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCND 240

Query: 241  ENNLPYKPDGGCMHVAENFSKKENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDL 300
            ENNLPYKPDGGCMHVAENFSKKENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDL
Sbjct: 241  ENNLPYKPDGGCMHVAENFSKKENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDL 300

Query: 301  YQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELML 360
            YQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELML
Sbjct: 301  YQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELML 360

Query: 361  QENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTI 420
            QENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTI
Sbjct: 361  QENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTI 420

Query: 421  EPLLKEETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKL 480
            EPLLKEETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKL
Sbjct: 421  EPLLKEETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKL 480

Query: 481  SCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTH 540
            SCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTH
Sbjct: 481  SCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTH 540

Query: 541  LTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEE 600
            LTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEE
Sbjct: 541  LTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEE 600

Query: 601  LSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQEANNSAGKTIH 660
            LSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQEANNSAGKTIH
Sbjct: 601  LSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQEANNSAGKTIH 660

Query: 661  RKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSEREAYSPLELLDN 720
            RKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSEREAYSPLELLDN
Sbjct: 661  RKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSEREAYSPLELLDN 720

Query: 721  LSGADVRQNRSKENVSMMMLGPQTLSIRNSVTPVQASSDSFYNKKSYSISPSFTKQGNNS 780
            LSGADVRQNRSKENVSMMMLGPQTLSIRNSVTPVQASSDSFYNKKSYSISPSFTKQGNNS
Sbjct: 721  LSGADVRQNRSKENVSMMMLGPQTLSIRNSVTPVQASSDSFYNKKSYSISPSFTKQGNNS 780

Query: 781  KPSNHVSEPGNIVSNKEVASLTVENNAFSCDPGYVEKSPSFCCNEQETFRPVSSEVRGRK 840
            KPSNHVSEPGNIVSNKEVASLTVENNAFSCDPGYVEKSPSFCCNEQETFRPVSSEVRGRK
Sbjct: 781  KPSNHVSEPGNIVSNKEVASLTVENNAFSCDPGYVEKSPSFCCNEQETFRPVSSEVRGRK 840

Query: 841  ITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPKISQEPNVAGE 900
            ITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPKISQEPNVAGE
Sbjct: 841  ITKNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGELSFTSEVPKISQEPNVAGE 900

Query: 901  HQSTDSKYMETPVKKEPSDDLRELPVLDCGWIKPDICASNSAESEIKRDPKDVNTSLGEV 960
            HQSTDSKYMETPVKKEPSDDLRELPVLDCGWIKPDICASNSAESEIKRDPKDVNTSLGEV
Sbjct: 901  HQSTDSKYMETPVKKEPSDDLRELPVLDCGWIKPDICASNSAESEIKRDPKDVNTSLGEV 960

Query: 961  ANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVCKSKDSRNADFMVGEC 1020
            ANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVCKSKDSRNADFMVGEC
Sbjct: 961  ANETSENETLGDFSEQIKGSDLDEKHRFTDKVITKEEKENIYEVCKSKDSRNADFMVGEC 1020

Query: 1021 QFAVPVPKPLCLLVPPLNLSGRQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKN 1080
            QFAVPVPKPLCLLVPPLNLSGRQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKN
Sbjct: 1021 QFAVPVPKPLCLLVPPLNLSGRQEDTILNTWMNDFRFLGKHSVLKLQNPETCEIFKREKN 1080

Query: 1081 VGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELC 1140
            VGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELC
Sbjct: 1081 VGVFQKSLGLMIPYKYCKFHFNTLRGCERPLCKFAHVPEQGDEKVCMDVFKKYININELC 1140

Query: 1141 LLQRAVNIFMEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLK 1200
            LLQRAVNIFMEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLK
Sbjct: 1141 LLQRAVNIFMEYYRKFPPGVYFDLQVLNDLLNSLLKHCLLKEVFQIVNLSIMVKMLPSLK 1200

Query: 1201 ILLNIFEYVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAV 1260
            ILLNIFEYVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAV
Sbjct: 1201 ILLNIFEYVATMKLRNAVPALIDIFCKLVEAGMVLDPEHFNYIVKLLYQVQASKQEITAV 1260

Query: 1261 LEMKSRLQMRRFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFC 1320
            LEMKSRLQMRRFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFC
Sbjct: 1261 LEMKSRLQMRRFKKNWKCDLDSALNKLEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFC 1320

Query: 1321 ACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSK 1380
            ACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSK
Sbjct: 1321 ACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGISAMYFYHKLLQWSK 1380

Query: 1381 GRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMRESEWI 1440
            GRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMRESEWI
Sbjct: 1381 GRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMRESEWI 1440

Query: 1441 INTPLWPCDRLDVLNRHNLLCTIAHEILAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSL 1500
            INTPLWPCDRLDVLNRHNLLCTIAHEILAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSL
Sbjct: 1441 INTPLWPCDRLDVLNRHNLLCTIAHEILAKSLYRQTFEVLQNLPGFQNSQETVEVSQYSL 1500

Query: 1501 LFNKLLGSCIESSSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSA 1560
            LFNKLLGSCIESSSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSA
Sbjct: 1501 LFNKLLGSCIESSSLGMSSSVAEFMISKSIPIDFSFLRRLITSLGRSRLWLKARAHYKSA 1560

Query: 1561 LSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKR 1620
            LSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKR
Sbjct: 1561 LSLGCYPPLEGNLYRKLLLIPSYLSEIEMLLAIEIFMVSNASSIQSPGTSTQILQIVLKR 1620

Query: 1621 CEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENM 1680
            CEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENM
Sbjct: 1621 CEDNQSRSNDDYQAAVERLIMAARISDPKLFVKHMTVNVNKEQVYSLEHCSALKWLKENM 1680

Query: 1681 KWAGKVWLFSNH 1692
            KWAGKVWLFSNH
Sbjct: 1681 KWAGKVWLFSNH 1692


>gi|211059431 RANBP2-like and GRIP domain containing 4 [Homo sapiens]
          Length = 1758

 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 62/243 (25%), Positives = 99/243 (40%), Gaps = 30/243 (12%)

Query: 699  RKEVNAKSSEREAYSPLELLDNLSGADVR---QNRSKENVSMMMLGPQTLSIRNSVTPVQ 755
            R+EV A   E +    L+L  + S +  R   +N   ++V     G QT     +   V 
Sbjct: 816  RQEVKAIKEEMQE---LKLNSSKSASHHRWPTENYGPDSVPDGYQGSQTF--HGAPLTVA 870

Query: 756  ASSDSFYNKKSYSISPSFTKQGNNSKPSNHVSEPGN----IVSNKEVASLTVENNAFS-- 809
             +  S Y    YS SP++  Q      +N     G+      S KE  S+ V  + F   
Sbjct: 871  TTGPSVY----YSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIPVSADGFKFG 926

Query: 810  -CDPGYVEKSPSFCCNEQETFRP--VSSEVRGRKIT--KNFSEVGFPDILKAYEDDVLLI 864
              +PG  EK           F+   +S +  GR +   +  S   F D+ K+   +    
Sbjct: 927  ISEPGNQEKESEKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQF 986

Query: 865  DVIQDDPDLFGVSNEGELSFTSEVPKISQEPNVAGEHQSTDSKYMETPVKKEPSDDLREL 924
               + DP+  G S  GE  F+S+  K++ + N +G+ +  D  Y     K E SDD+   
Sbjct: 987  G--KKDPNFKGFSGAGEKLFSSQCGKMANKANTSGDFEKDDDAY-----KTEDSDDIHFE 1039

Query: 925  PVL 927
            PV+
Sbjct: 1040 PVV 1042


>gi|147903302 MAP7 domain containing 3 [Homo sapiens]
          Length = 876

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 120/588 (20%), Positives = 224/588 (38%), Gaps = 51/588 (8%)

Query: 104 KEAELPLQTERHTKEK-RKVTEASSDDPQPGLDLVRK---ESLTSSESFQTVECLQSLGK 159
           KE +  LQ E+  +E+ RK+ E    + Q  +    K   +     E F  +   ++L +
Sbjct: 94  KERKTKLQYEKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAI-LYRTLER 152

Query: 160 ESIIEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEF-QDELYKNTPKYSCNILSP-- 216
             + +  +++  +    ++ N   K     +    K+E     L +  P  S  + +   
Sbjct: 153 RRLADDYQQKRWSWGGSAMANSESKTANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVA 212

Query: 217 ----EVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFS------KKENLR 266
               + E +S L  RD N   HS    ++     +  G   +V +  +        + LR
Sbjct: 213 KRKTDKERSSSLNRRDSNL--HSSTDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELR 270

Query: 267 SLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEESSV 326
           ++     T  IP   + EE+ +   +  P+ S     + N  + C     +  +  ++ V
Sbjct: 271 AVMFPMSTMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFC---NTSMEASPKAGV 327

Query: 327 GRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSH 386
           G  P             V+ +  + +   SE+ +  +  ++   EA  K  L  + KVS 
Sbjct: 328 GMAPEVSTDSFPVVSVDVSPVVSTYD---SEMSMDASPELSI--EALPKVDLETVPKVS- 381

Query: 387 NTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDF 446
             V+  +  L  P  V  E   E  V A  + ++E   K   E A  P      + KE  
Sbjct: 382 -IVASPEASLEAPPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVA--PKESVKGSPKESM 438

Query: 447 KSMKSFIGKSPNEYHIE---RRSSREDLRSASEELKLSCQRTIPMTGKRTWPYYSCARIS 503
           ++    + K+  +  +E     S +   R A ++ ++  Q  IP+  KR   Y  C + S
Sbjct: 439 EASPEAMVKASPKTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWS 498

Query: 504 AWCWKKASLPESSYFLRGSQESCRQVDVP--KHQTNQTHLTDSKLLLQSSLTETNTESSS 561
           +       LP      R  Q++C    +P    Q+ QT      + +Q +L+  +  S+ 
Sbjct: 499 SSPENACGLPSPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTV 558

Query: 562 KEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEELS-------RRGSEVISNTTE 614
           K+K ++ S   +   A+    M+ +E   K    I + E +       RR +       E
Sbjct: 559 KKKKETVSKTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEE 618

Query: 615 DTQLTSETQSLTGNK-----KKARGNLTKLNLTATSKDGQEANNSAGK 657
           + +   E Q     K     K+A G   + +L    KDGQ+ N +  K
Sbjct: 619 EERQREEMQQRVIKKSKDMAKEAVGGQAEDHLKL--KDGQQQNETKKK 664


>gi|150418007 RAN binding protein 2 [Homo sapiens]
          Length = 3224

 Score = 45.1 bits (105), Expect = 6e-04
 Identities = 44/165 (26%), Positives = 70/165 (42%), Gaps = 23/165 (13%)

Query: 770  SPSFTKQGNNSKPSNHVSEPGNIVSNKEVASLTVENNAFS---CDPGYVEKSPSFCCNEQ 826
            SPSF  QG+++             S KE  S+ V  + F     +PG  EK         
Sbjct: 1869 SPSFMFQGSSNT---------EFKSTKEGFSIPVSADGFKFGISEPGNQEKKSEKPLENG 1919

Query: 827  ETFRP--VSSEVRGRKIT--KNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFGVSNEGEL 882
              F+   +S +  GR +   +  S   F D+ K+   +       + DP+  G S  GE 
Sbjct: 1920 TGFQAQDISGQKNGRGVIFGQTSSTFTFADLAKSTSGEGFQFG--KKDPNFKGFSGAGEK 1977

Query: 883  SFTSEVPKISQEPNVAGEHQSTDSKYMETPVKKEPSDDLRELPVL 927
             F+S+  K++ + N +G+ +  D  Y     K E SDD+   PV+
Sbjct: 1978 LFSSQYGKMANKANTSGDFEKDDDAY-----KTEDSDDIHFEPVV 2017


>gi|157266273 RANBP2-like and GRIP domain containing 1 [Homo sapiens]
          Length = 1756

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 44/172 (25%), Positives = 71/172 (41%), Gaps = 18/172 (10%)

Query: 767  YSISPSFTKQGNNSKPSNHVSEPGN----IVSNKEVASLTVENNAFS---CDPGYVEKSP 819
            YS SP++  Q      +N     G+      S KE  S+ V  + F     +PG  EK  
Sbjct: 870  YSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIAVSADGFKFGISEPGNQEKKS 929

Query: 820  SFCCNEQETFRP--VSSEVRGRKIT--KNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFG 875
                     F+   +S +  GR +   +  S   F D+ K+   +       + DP+  G
Sbjct: 930  EKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFG--KKDPNFKG 987

Query: 876  VSNEGELSFTSEVPKISQEPNVAGEHQSTDSKYMETPVKKEPSDDLRELPVL 927
             S  GE  F+S+  K++ + N +G+ +  D        K E SDD+   PV+
Sbjct: 988  FSGAGEKLFSSQCGKMANKANTSGDFEKDDD-----ACKTEDSDDIHFEPVV 1034


>gi|118200331 RANBP2-like and GRIP domain containing 2 [Homo
           sapiens]
          Length = 1013

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 44/172 (25%), Positives = 71/172 (41%), Gaps = 18/172 (10%)

Query: 767 YSISPSFTKQGNNSKPSNHVSEPGN----IVSNKEVASLTVENNAFS---CDPGYVEKSP 819
           YS SP++  Q      +N     G+      S KE  S+ V  + F     +PG  EK  
Sbjct: 127 YSQSPAYNSQYLLRPAANVTPTKGSSNTEFKSTKEGFSIAVSADGFKFGISEPGNQEKKS 186

Query: 820 SFCCNEQETFRP--VSSEVRGRKIT--KNFSEVGFPDILKAYEDDVLLIDVIQDDPDLFG 875
                    F+   +S +  GR +   +  S   F D+ K+   +       + DP+  G
Sbjct: 187 EKPLENDTGFQAQDISGQKNGRGVIFGQTSSTFTFADVAKSTSGEGFQFG--KKDPNFKG 244

Query: 876 VSNEGELSFTSEVPKISQEPNVAGEHQSTDSKYMETPVKKEPSDDLRELPVL 927
            S  GE  F+S+  K++ + N +G+ +  D        K E SDD+   PV+
Sbjct: 245 FSGAGEKLFSSQCGKMANKANTSGDFEKDDD-----ACKTEDSDDIHFEPVV 291


>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
          Length = 2039

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 83/400 (20%), Positives = 149/400 (37%), Gaps = 58/400 (14%)

Query: 100  LEAAKEAELPLQTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQ---- 155
            LE   + E  ++ ++ TKEK    E +  + +   D ++KES  S    +  +  +    
Sbjct: 697  LEKKSKLEKNIKDDKSTKEKHVSKERNFKEER---DKIKKESEKSFREEKIKDLKEEREN 753

Query: 156  ----------SLGKESIIEGIKRRIRNKKLKSLENPPLKITEN----EATQNIKVEFQDE 201
                      SLG  +I E I   +  K++  +E     I E+    E    IK +  ++
Sbjct: 754  IPTDKDSEFTSLGMSAIEESIGLHLVEKEI-DIEKQEKHIKESKEKPEKRSQIKEKDIEK 812

Query: 202  LYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSK 261
            + + T +    I          L L +C          +++ L       C    E   K
Sbjct: 813  MERKTFEKEKKIKHEHKSEKDKLDLSEC-----VDKIKEKDKLYSHHTEKCHKEGE---K 864

Query: 262  KENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPE-ESDLYQSKTNGLLSCLQHEKNKYS 320
             +N  ++ +  D     + +  + +     K  PE E  L +SK   L+     + +   
Sbjct: 865  SKNTAAIKKTDDREKSREKMDRKHD-----KEKPEKERHLAESKEKHLMEKKNKQSDNSE 919

Query: 321  IEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNV 380
              +S  G+   K  +L +K  E   +    N  N   +  ++   I DG +A+ + PL++
Sbjct: 920  YSKSEKGKNKEKDRELDKK--EKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSL 977

Query: 381  LRKVSHNTVSLMDHLLSVPETVEKETSS---------EHHVNAVFQKTIEPLLKEETENA 431
              K         D  L  P+  EK+            + H + +    I  LLK ++E A
Sbjct: 978  KEKTK-------DEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI---QINSLLKLKSE-A 1026

Query: 432  SEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDL 471
             +P    S ASK+     K  +     +   ER  S +DL
Sbjct: 1027 DKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDL 1066


>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
          Length = 2062

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 83/400 (20%), Positives = 149/400 (37%), Gaps = 58/400 (14%)

Query: 100  LEAAKEAELPLQTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQ---- 155
            LE   + E  ++ ++ TKEK    E +  + +   D ++KES  S    +  +  +    
Sbjct: 720  LEKKSKLEKNIKDDKSTKEKHVSKERNFKEER---DKIKKESEKSFREEKIKDLKEEREN 776

Query: 156  ----------SLGKESIIEGIKRRIRNKKLKSLENPPLKITEN----EATQNIKVEFQDE 201
                      SLG  +I E I   +  K++  +E     I E+    E    IK +  ++
Sbjct: 777  IPTDKDSEFTSLGMSAIEESIGLHLVEKEI-DIEKQEKHIKESKEKPEKRSQIKEKDIEK 835

Query: 202  LYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSK 261
            + + T +    I          L L +C          +++ L       C    E   K
Sbjct: 836  MERKTFEKEKKIKHEHKSEKDKLDLSEC-----VDKIKEKDKLYSHHTEKCHKEGE---K 887

Query: 262  KENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPE-ESDLYQSKTNGLLSCLQHEKNKYS 320
             +N  ++ +  D     + +  + +     K  PE E  L +SK   L+     + +   
Sbjct: 888  SKNTAAIKKTDDREKSREKMDRKHD-----KEKPEKERHLAESKEKHLMEKKNKQSDNSE 942

Query: 321  IEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNV 380
              +S  G+   K  +L +K  E   +    N  N   +  ++   I DG +A+ + PL++
Sbjct: 943  YSKSEKGKNKEKDRELDKK--EKSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSL 1000

Query: 381  LRKVSHNTVSLMDHLLSVPETVEKETSS---------EHHVNAVFQKTIEPLLKEETENA 431
              K         D  L  P+  EK+            + H + +    I  LLK ++E A
Sbjct: 1001 KEKTK-------DEPLKTPDGKEKDKKDKDIDRYKERDKHKDKI---QINSLLKLKSE-A 1049

Query: 432  SEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDL 471
             +P    S ASK+     K  +     +   ER  S +DL
Sbjct: 1050 DKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERMLSLKDL 1089


>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
            sapiens]
          Length = 1591

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 106/560 (18%), Positives = 221/560 (39%), Gaps = 83/560 (14%)

Query: 262  KENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEE---SDLYQSKTNGL---------L 309
            ++ L SL  + +      + +TEEN   + KL  E     ++ Q+K N           +
Sbjct: 864  QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAV 923

Query: 310  SCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTE----MNFSNEYNKSELMLQENQM 365
             CLQ+EK++  +E  ++       +K  +++ E V E    ++  N+  K +L+  E Q 
Sbjct: 924  ICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEND-EKLQLLRAELQS 982

Query: 366  IADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLK 425
            +      E +  L V R +      + DH +S+ E ++KE  ++  +N + +   E + +
Sbjct: 983  LEQSHLKELEDTLQV-RHIQEFEKVMTDHRVSLEE-LKKE--NQQIINQIQESHAEIIQE 1038

Query: 426  EETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIE---RRSSREDLRSASEELKLSC 482
            +E +              ++ K   S +  +  +  +E   + +  ++++   EE +   
Sbjct: 1039 KEKQ-------------LQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQ 1085

Query: 483  QRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLT 542
            + T+                      K+ L + +  LR       Q     ++  Q  L 
Sbjct: 1086 KETL----------------------KSLLEQETENLRTEISKLNQKIQDNNENYQVGLA 1123

Query: 543  DSKLLLQSSLTETNTESSSKEKLDSN--SNCLSSVSAVEPTLMVI----KEPIIKDDKKI 596
            + + L+     +  +E  S+ + +SN     L+ V+++      I    KE II+   K+
Sbjct: 1124 ELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL 1183

Query: 597  KSE--ELSRRGSEVISNTTEDTQ-----LTSETQSLTGNKKKARGNLT-KLNLTATSKDG 648
             SE   L R+  E I+   E  +     L  + Q L  ++++ R  L  KLN      + 
Sbjct: 1184 DSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNC-----EK 1238

Query: 649  QEANNSAGKTIHRKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSE 708
             EA  +A K    +  + ++  +  + VK L        K P + +       + A+  E
Sbjct: 1239 DEAIQTALKEFKLEREVVEKELL--EKVKHLENQIA---KSPAIDSTRGDSSSLVAELQE 1293

Query: 709  REAYSPLELLDNLSGADVRQNRSKENVSMMMLGPQTLSIRNSVTPVQASSDSFYNKKSYS 768
            +      + L+ L   + R+N   +NV   ++  Q  +    +T  +   ++  N  S  
Sbjct: 1294 KLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353

Query: 769  ISPSFTKQGNNSKPSNHVSE 788
            +  +  +Q  +      +SE
Sbjct: 1354 LKSTMQQQERDKDLIESLSE 1373


>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
            sapiens]
          Length = 1594

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 106/560 (18%), Positives = 221/560 (39%), Gaps = 83/560 (14%)

Query: 262  KENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEE---SDLYQSKTNGL---------L 309
            ++ L SL  + +      + +TEEN   + KL  E     ++ Q+K N           +
Sbjct: 864  QKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEAV 923

Query: 310  SCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTE----MNFSNEYNKSELMLQENQM 365
             CLQ+EK++  +E  ++       +K  +++ E V E    ++  N+  K +L+  E Q 
Sbjct: 924  ICLQNEKDQKLLEMENIMHSQNCEIKELKQSREIVLEDLKKLHVEND-EKLQLLRAELQS 982

Query: 366  IADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLK 425
            +      E +  L V R +      + DH +S+ E ++KE  ++  +N + +   E + +
Sbjct: 983  LEQSHLKELEDTLQV-RHIQEFEKVMTDHRVSLEE-LKKE--NQQIINQIQESHAEIIQE 1038

Query: 426  EETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIE---RRSSREDLRSASEELKLSC 482
            +E +              ++ K   S +  +  +  +E   + +  ++++   EE +   
Sbjct: 1039 KEKQ-------------LQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESRAQQ 1085

Query: 483  QRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLT 542
            + T+                      K+ L + +  LR       Q     ++  Q  L 
Sbjct: 1086 KETL----------------------KSLLEQETENLRTEISKLNQKIQDNNENYQVGLA 1123

Query: 543  DSKLLLQSSLTETNTESSSKEKLDSN--SNCLSSVSAVEPTLMVI----KEPIIKDDKKI 596
            + + L+     +  +E  S+ + +SN     L+ V+++      I    KE II+   K+
Sbjct: 1124 ELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKL 1183

Query: 597  KSE--ELSRRGSEVISNTTEDTQ-----LTSETQSLTGNKKKARGNLT-KLNLTATSKDG 648
             SE   L R+  E I+   E  +     L  + Q L  ++++ R  L  KLN      + 
Sbjct: 1184 DSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNC-----EK 1238

Query: 649  QEANNSAGKTIHRKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSE 708
             EA  +A K    +  + ++  +  + VK L        K P + +       + A+  E
Sbjct: 1239 DEAIQTALKEFKLEREVVEKELL--EKVKHLENQIA---KSPAIDSTRGDSSSLVAELQE 1293

Query: 709  REAYSPLELLDNLSGADVRQNRSKENVSMMMLGPQTLSIRNSVTPVQASSDSFYNKKSYS 768
            +      + L+ L   + R+N   +NV   ++  Q  +    +T  +   ++  N  S  
Sbjct: 1294 KLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDK 1353

Query: 769  ISPSFTKQGNNSKPSNHVSE 788
            +  +  +Q  +      +SE
Sbjct: 1354 LKSTMQQQERDKDLIESLSE 1373


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 110/547 (20%), Positives = 215/547 (39%), Gaps = 90/547 (16%)

Query: 156  SLGKESIIEGIKRRI----RNKKLKSLENPPLKITENEATQNIK-VEFQDELYKNT-PKY 209
            ++ KE    G + +I    R  +  S E   LK T  + T+N++ VE   +  K T  + 
Sbjct: 1381 TMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEV 1440

Query: 210  SCNILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLA 269
            S      EVE   V ++R      + +  +D        +     + +   K+ N R   
Sbjct: 1441 SQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCL 1500

Query: 270  EKSDTNSIPQLLQTEENVMG------VNKLLPEESDLYQ-------------------SK 304
            E  D N+  Q +Q +           +NKL  +E +L +                   ++
Sbjct: 1501 E--DENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558

Query: 305  TNGLLSCLQHEKNKYSIEESSVGRKPR----KRMKLSEKAD--------ETVTEMNFSNE 352
                L  LQ +K K   E + + R       KR KL E+ +        + +   N + +
Sbjct: 1559 FQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618

Query: 353  YNKSELM-------LQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKE 405
              ++ ++       L++ + + DG   E +     LR++S    +L   LL   E+V++ 
Sbjct: 1619 LEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQ- 1677

Query: 406  TSSEHHVNAVFQKTIEPLLK---------EETENASEPLGYESMASKEDFKSMK---SFI 453
                H  N  FQK IE   +         E  ++ +E L  E +  +E+ ++++     +
Sbjct: 1678 ---AHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDL 1734

Query: 454  GKSPNEYHIERRSSREDLRSASEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASL- 512
             +  +E   ++ ++  +LRS   +L++S  RT+ + G           I+    ++ +L 
Sbjct: 1735 RRGRSEADSDKNATILELRS---QLQISNNRTLELQG----------LINDLQRERENLR 1781

Query: 513  PESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLLQSSLTETNTESSSK--EKLDSNSN 570
             E   F + + E+  ++   K+Q  Q       LL++  + E +     +  ++L+   +
Sbjct: 1782 QEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKS 1841

Query: 571  CLSSVSAVEPTLMVIKEPIIKD------DKKIKSEELSRRGSEVISNTTEDTQLTSETQS 624
             L + + V+  L   K+ I  D          K E + +  SE   +  E   L SE + 
Sbjct: 1842 TLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIER 1901

Query: 625  LTGNKKK 631
            L    K+
Sbjct: 1902 LQAEIKR 1908


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 40.4 bits (93), Expect = 0.015
 Identities = 78/386 (20%), Positives = 135/386 (34%), Gaps = 70/386 (18%)

Query: 260  SKKENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKY 319
            +K++NL S  E  +     QLLQ  +       +L       QS  NGL+  ++  K K 
Sbjct: 2466 AKEQNLSSQVECLELEKA-QLLQGLDEAKNNYIVL-------QSSVNGLIQEVEDGKQKL 2517

Query: 320  SIEESSVGRKPRK---RMKLSEKADETVTEMNFSNEYN------------KSELMLQENQ 364
              ++  + R   +   + +L  K  +   E     E N            K +++  +N 
Sbjct: 2518 EKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNA 2577

Query: 365  MIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLL 424
             + D  E    S  N+  ++    +  M  +  V +   KET  +  ++ + QKT E  L
Sbjct: 2578 SLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAE--L 2635

Query: 425  KEETENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQR 484
            +EE       L  E     E+ KS K  +               ++L   + ELK S   
Sbjct: 2636 QEELSGEKNRLAGELQLLLEEIKSSKDQL---------------KELTLENSELKKSLD- 2679

Query: 485  TIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTDS 544
                                 C  K  + +        +E   +  +  H+  + H    
Sbjct: 2680 ---------------------CMHKDQVEKEGKV----REEIAEYQLRLHEAEKKH---Q 2711

Query: 545  KLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEELSRR 604
             LLL ++        + +EKL S   CLSS   +E  L+   +  + +  K  ++ L   
Sbjct: 2712 ALLLDTNKQYEVEIQTYREKLTSKEECLSS-QKLEIDLLKSSKEELNNSLKATTQILEEL 2770

Query: 605  GSEVISNTTEDTQLTSETQSLTGNKK 630
                + N     QL  E +   G  K
Sbjct: 2771 KKTKMDNLKYVNQLKKENERAQGKMK 2796



 Score = 38.5 bits (88), Expect = 0.056
 Identities = 52/231 (22%), Positives = 95/231 (41%), Gaps = 20/231 (8%)

Query: 257  ENFSKKEN--LRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKT----NGLLS 310
            E F   EN   R  +EK+        L+ +  V+   KL  E+ +  + K        LS
Sbjct: 1895 ERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELS 1954

Query: 311  CLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGK 370
             +  E+N+   E  ++ +K     +LSEK  E   E+    E ++SE +           
Sbjct: 1955 VVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQEL----ESHQSECL-----HCIQVA 2005

Query: 371  EAETKSPLNVLRKVSHNTVSLM---DHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEE 427
            EAE K    +L+ +S +   L+    HL    +++EK++ +        +  I  L KE+
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065

Query: 428  TENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEEL 478
                 E    ++  S+ D++ +   + K+     +E+      L S  EE+
Sbjct: 2066 ELLVKESESLQARLSESDYEKLN--VSKALEAALVEKGEFALRLSSTQEEV 2114



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 56/327 (17%), Positives = 133/327 (40%), Gaps = 24/327 (7%)

Query: 138 RKESLTSSESFQTV--ECLQSLGKESIIEGIKRRIRNKKLKSLENPPLKITENEATQNIK 195
           ++E      SFQT+  EC+Q   K  + + +++      +   E   L   + +   N++
Sbjct: 397 QEELSRQQRSFQTLDQECIQM--KARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLE 454

Query: 196 VEFQDELYKNTPKYSCNILSPEVENNSVLKLRDCNCFPHSKG-------CNDENNLPYKP 248
            EF+ +L +    +  + +       S+ +++  N    S         C+ E  L  K 
Sbjct: 455 -EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAEL--KN 511

Query: 249 DGGCMHVAENFSKKENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSK--TN 306
              C++ ++NF+++   ++ ++++    + + +  +EN + + KL    +DL + +  + 
Sbjct: 512 IKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQ 571

Query: 307 GLLSCLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMI 366
            LL   +H   + + + S   ++ +  +   E   +   E+    E         EN+ +
Sbjct: 572 DLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL--KEEKTLFSCWKSENEKL 629

Query: 367 ADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSE---HHVNAVFQKTIEPL 423
               E+E +   N+  K++H    L    +   E  E+  + E    +++   +     L
Sbjct: 630 LTQMESEKE---NLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686

Query: 424 LKEETENASEPLGYESMASKEDFKSMK 450
             +  E  ++ L Y  +  K +F   K
Sbjct: 687 DSKSVEVETQKLAYMELQQKAEFSDQK 713



 Score = 35.0 bits (79), Expect = 0.62
 Identities = 60/290 (20%), Positives = 115/290 (39%), Gaps = 30/290 (10%)

Query: 321  IEESSVGRKPRKRMKLSE--KADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPL 378
            + +S V    ++  KL E   A + V     S   NK +    E Q++ D  E E ++ +
Sbjct: 873  MHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEK----ELQLLNDKVETE-QAEI 927

Query: 379  NVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEE--TENASEPLG 436
              L+K +H     +  L  + ET+  E      + ++ ++ IE L +E    +  +  L 
Sbjct: 928  QELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN 987

Query: 437  YESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQRTIPMTG------ 490
             E M   +  +S  ++I         ER  S  +L    ++ KL   +    TG      
Sbjct: 988  QEKMNLIQKSESFANYID--------EREKSISELSDQYKQEKLILLQRCEETGNAYEDL 1039

Query: 491  --KRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLL 548
              K        +++     +  SL E+    +   E  ++    +HQ   T L  ++   
Sbjct: 1040 SQKYKAAQEKNSKLECLLNECTSLCENR---KNELEQLKEAFAKEHQEFLTKLAFAEERN 1096

Query: 549  QSSLTETNT--ESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKI 596
            Q+ + E  T  ++   E  D+ +N  S    ++  +M +KE   K  K++
Sbjct: 1097 QNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEV 1146


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 39.3 bits (90), Expect = 0.033
 Identities = 74/405 (18%), Positives = 153/405 (37%), Gaps = 66/405 (16%)

Query: 275  NSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGL----------LSCLQHEKNKYSIEES 324
            N   QL  TEE ++ ++ L    S+  +S+   L          +  L+ EKN  S + S
Sbjct: 715  NFTSQLKATEEKLLDLDALRKASSE-GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773

Query: 325  SVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEA-----ETKSPLN 379
            S+ R+ + R        E ++E++   E  + EL + + +     +EA       +  +N
Sbjct: 774  SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 833

Query: 380  VLRKVSHNTVSLMDHLLSVPETV--------EKETSSEHHVNA--VFQKTIEPLLKEETE 429
             L +       L   L  + E +        EK+   E  + A    +  I  ++K   +
Sbjct: 834  KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 893

Query: 430  NASE--PLGYESMASKEDFKSMK----------SFIGKSPNEYHIERRSSREDLRSASEE 477
            N+S+   +  E    + D + ++          SF+ KS  +  ++   S+++     EE
Sbjct: 894  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 953

Query: 478  LKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVP-KHQT 536
             K   +R +    K+                          +  S   C+++    +  T
Sbjct: 954  EKKELERKLSDLEKK--------------------------METSHNQCQELKARYERAT 987

Query: 537  NQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKI 596
            ++T     ++L     T  +TE   K   + NS  L  +  +       K     +D   
Sbjct: 988  SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ 1047

Query: 597  KSEELSRRGSEVISNTTEDTQLTSETQS-LTGNKKKARGNLTKLN 640
              E++++  +E +++  +  Q  ++ Q+ L   K+    N+ +LN
Sbjct: 1048 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN 1092


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 39.3 bits (90), Expect = 0.033
 Identities = 74/405 (18%), Positives = 153/405 (37%), Gaps = 66/405 (16%)

Query: 275  NSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGL----------LSCLQHEKNKYSIEES 324
            N   QL  TEE ++ ++ L    S+  +S+   L          +  L+ EKN  S + S
Sbjct: 750  NFTSQLKATEEKLLDLDALRKASSE-GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 808

Query: 325  SVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEA-----ETKSPLN 379
            S+ R+ + R        E ++E++   E  + EL + + +     +EA       +  +N
Sbjct: 809  SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 868

Query: 380  VLRKVSHNTVSLMDHLLSVPETV--------EKETSSEHHVNA--VFQKTIEPLLKEETE 429
             L +       L   L  + E +        EK+   E  + A    +  I  ++K   +
Sbjct: 869  KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 928

Query: 430  NASE--PLGYESMASKEDFKSMK----------SFIGKSPNEYHIERRSSREDLRSASEE 477
            N+S+   +  E    + D + ++          SF+ KS  +  ++   S+++     EE
Sbjct: 929  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 988

Query: 478  LKLSCQRTIPMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVP-KHQT 536
             K   +R +    K+                          +  S   C+++    +  T
Sbjct: 989  EKKELERKLSDLEKK--------------------------METSHNQCQELKARYERAT 1022

Query: 537  NQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKI 596
            ++T     ++L     T  +TE   K   + NS  L  +  +       K     +D   
Sbjct: 1023 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ 1082

Query: 597  KSEELSRRGSEVISNTTEDTQLTSETQS-LTGNKKKARGNLTKLN 640
              E++++  +E +++  +  Q  ++ Q+ L   K+    N+ +LN
Sbjct: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN 1127


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 39.3 bits (90), Expect = 0.033
 Identities = 64/324 (19%), Positives = 120/324 (37%), Gaps = 30/324 (9%)

Query: 337  SEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLL 396
            S+ A+E     N +   NK E+M+ + +     +E   +      RK+   T  L D + 
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072

Query: 397  SVPETVEK-----ETSSEHHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDFKSMKS 451
             +   +++         E    A+ +   E L K         L  +    +EDF+S K+
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132

Query: 452  FIGKSPNEYHIERRSSREDLRSASEELKLSCQRTIPMTGKRTWPYYSCARISAWCWKKAS 511
                S N+   ++R   E+L +   EL+ +   T      RT      A +      K +
Sbjct: 1133 ----SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL------KKA 1182

Query: 512  LPESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNC 571
            L E +       +  RQ    +H T    L  S+ L Q+   + N E + +     N   
Sbjct: 1183 LEEETKNHEAQIQDMRQ----RHATALEEL--SEQLEQAKRFKANLEKNKQGLETDNKEL 1236

Query: 572  LSSVSAVEPTLMVIKEPIIKDDKKIKSEELSRRGSEVISNTTEDTQLTSETQSLTGNKKK 631
               V  ++          +K + + K ++L  +  E+ +  +E  +L  E        + 
Sbjct: 1237 ACEVKVLQQ---------VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287

Query: 632  ARGNLTKLNLTATSKDGQEANNSA 655
               N++ L   A  K  + A ++A
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAA 1311



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 92/453 (20%), Positives = 182/453 (40%), Gaps = 68/453 (15%)

Query: 76   KAARRQVEGRRGPVSPSDSSDPRGLE-----AAKEAELPLQTERHTKEKRKVTEASSDDP 130
            KA+R + E ++  +S    +    LE      A + EL  + E+   E +K  E  + + 
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190

Query: 131  QPGLDLVRKESLTSSESF---------------QTVECLQSLGKE-----SIIEGIKRRI 170
            +  +  +R+   T+ E                 +  + L++  KE      +++ +K   
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250

Query: 171  RNKKLK---SLENPPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPEVENNSVLKLR 227
             +K+ K    ++    K++E +    ++VE  ++  K         L  E++N S L L 
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGD---RLRVELAEKASK---------LQNELDNVSTL-LE 1297

Query: 228  DCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEK--SDTNSIPQLLQTEE 285
            +       K   D  +L  +       + E   +K NL S   +   + NS+ +  + EE
Sbjct: 1298 EAEK-KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356

Query: 286  NVMG--VNKLLPEESDLYQSKTN-----GLLSCLQHEKNKYSIEESSVGRKPRKRMKLSE 338
                    ++L  +S L  +K       G +  L+  K K   +  ++ ++  ++    +
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYD 1416

Query: 339  KADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVL---RKVSHNTVSLMDHL 395
            K ++T   +    E +   + L   + +A   E + K    +L   + +S       D  
Sbjct: 1417 KLEKTKNRLQ--QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR- 1473

Query: 396  LSVPETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDFKSMKSFIGK 455
             +  E  EKET +     A+ ++ +E   KEE E  ++ L     A  ED  S K  +GK
Sbjct: 1474 -AEAEAREKETKALSLARAL-EEALEA--KEEFERQNKQL----RADMEDLMSSKDDVGK 1525

Query: 456  SPNEYHIERRSSR---EDLRSASEELKLSCQRT 485
            + +E    +R+     E++R+  EEL+   Q T
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 38.9 bits (89), Expect = 0.043
 Identities = 146/704 (20%), Positives = 280/704 (39%), Gaps = 118/704 (16%)

Query: 98   RGLEAAKEAELPL-QTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQS 156
            R +E+ K A + + Q +   KE     E+  +  + GL+L++        SF+  E L  
Sbjct: 708  RNVESLKCASMKMAQLQLENKE----LESEKEQLKKGLELLKA-------SFKKTERL-- 754

Query: 157  LGKESIIEGIKRRIRNKKL-KSLENPPLKITENEAT-QNIKVEFQDELYKNTP--KYSCN 212
               E   +G+   I N++L K+LEN   KI + E+  Q++++E Q  L KN    K S  
Sbjct: 755  ---EVSYQGLD--IENQRLQKTLENSNKKIQQLESELQDLEMENQT-LQKNLEELKISSK 808

Query: 213  ILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEKS 272
             L    + N  L+          K    EN                    + LR  AE  
Sbjct: 809  RLEQLEKENKSLEQETSQLEKDKKQLEKEN--------------------KRLRQQAEIK 848

Query: 273  DTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLL--SCLQ----HEKNKYSIEESSV 326
            DT         EEN + +  L  E   L  SK  G+   SC++     ++NK  ++ +++
Sbjct: 849  DTT-------LEENNVKIGNLEKENKTL--SKEIGIYKESCVRLKELEKENKELVKRATI 899

Query: 327  GRKPRKRMKLSEKADETVTEMNFSNEYNK-----------SELMLQENQMIADGK----E 371
              K    ++  +   E +     +N+  K            E +L + Q   D +    E
Sbjct: 900  DIKTLVTLR-EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE 958

Query: 372  AETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETEN- 430
            ++ +S L    ++    ++ ++  L       ++   E       +K  E L + + E  
Sbjct: 959  SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT---VKKNYEALKQRQDEER 1015

Query: 431  ---ASEPL-GYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQRTI 486
               +S P+ G ++   +E  ++ +  +        +ER ++   L++  + LK   ++  
Sbjct: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT--LQAEKQALKTQLKQLE 1073

Query: 487  PMTGKRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTD--S 544
                         A+I A   +  SL E +  L+ +Q +  QV+     +  T L +  +
Sbjct: 1074 TQNNNLQ------AQILALQRQTVSLQEQNTTLQ-TQNAKLQVENSTLNSQSTSLMNQNA 1126

Query: 545  KLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIK------EPIIKDDKKIKS 598
            +LL+Q S  E   ES  KE+ D  S   S +   E   ++ +      E +I     +KS
Sbjct: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKS 1186

Query: 599  EELSRRGSEVISNTTED--TQLTSETQSLTGNKKKARGNLTKL-----NLTATSKDGQEA 651
               + +  EV     ED   QL  +   L   +K  +    K+     N    + + ++ 
Sbjct: 1187 ---AHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKL 1243

Query: 652  NNSAGKTIHRKACIAQQTFIV----PDLVKILNTGRLTNFKIPLLKNK-SEKRKEVNAKS 706
                 +  H  + + ++T ++     +L  +LN  +L   ++    +K  E+ ++++  S
Sbjct: 1244 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1303

Query: 707  SEREAYSPLELLDNLSGADVRQNRS-KENVSMMMLGPQTLSIRN 749
            ++    +  ELL  L G    +NR   + +  +ML  +TL  +N
Sbjct: 1304 TKLN--NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1345


>gi|58535453 CDK5 regulatory subunit associated protein 2 isoform b
           [Homo sapiens]
          Length = 1814

 Score = 38.5 bits (88), Expect = 0.056
 Identities = 47/189 (24%), Positives = 75/189 (39%), Gaps = 6/189 (3%)

Query: 294 LPEESDLYQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRM---KLSEKADET-VTEMNF 349
           L EE  L       L+ CL+ EK++ +  + +V     + +      EK  ET   +M  
Sbjct: 222 LIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH 281

Query: 350 SNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSE 409
             E N  E  +Q  +     KE E  +      K       L   L S  + VE+  S  
Sbjct: 282 QKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEI 341

Query: 410 HHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDFKS--MKSFIGKSPNEYHIERRSS 467
             ++A F K  E L K +T+       YE+  S ++  S  ++S       E H  RRS 
Sbjct: 342 EKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSI 401

Query: 468 REDLRSASE 476
           ++  +  S+
Sbjct: 402 KKITQELSD 410


>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
           [Homo sapiens]
          Length = 1893

 Score = 38.5 bits (88), Expect = 0.056
 Identities = 47/189 (24%), Positives = 75/189 (39%), Gaps = 6/189 (3%)

Query: 294 LPEESDLYQSKTNGLLSCLQHEKNKYSIEESSVGRKPRKRM---KLSEKADET-VTEMNF 349
           L EE  L       L+ CL+ EK++ +  + +V     + +      EK  ET   +M  
Sbjct: 222 LIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEH 281

Query: 350 SNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSE 409
             E N  E  +Q  +     KE E  +      K       L   L S  + VE+  S  
Sbjct: 282 QKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEI 341

Query: 410 HHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDFKS--MKSFIGKSPNEYHIERRSS 467
             ++A F K  E L K +T+       YE+  S ++  S  ++S       E H  RRS 
Sbjct: 342 EKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSI 401

Query: 468 REDLRSASE 476
           ++  +  S+
Sbjct: 402 KKITQELSD 410


>gi|45505178 cancer antigen 1 [Homo sapiens]
          Length = 641

 Score = 38.5 bits (88), Expect = 0.056
 Identities = 29/96 (30%), Positives = 53/96 (55%), Gaps = 5/96 (5%)

Query: 111 QTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTV-ECLQSLGKESIIEGIKRR 169
           + ER  + K+++ +A++      LDL+++E     + F ++ E  Q L KE++ E  K +
Sbjct: 315 EVERLQQLKKELEKATAS----ALDLLKREKEAQEQEFLSLQEEFQKLEKENLEERQKLK 370

Query: 170 IRNKKLKSLENPPLKITENEATQNIKVEFQDELYKN 205
            R +KL +       ++ENE T+NIK++ Q    KN
Sbjct: 371 SRLEKLLTQVRNLQFMSENERTKNIKLQQQINEVKN 406


>gi|156139122 CXXC finger 6 [Homo sapiens]
          Length = 2136

 Score = 38.1 bits (87), Expect = 0.073
 Identities = 102/530 (19%), Positives = 200/530 (37%), Gaps = 73/530 (13%)

Query: 237  GCNDENNLPYKPDGGCMHVAENFSKKENLRS--LAEKSDTNSIPQLLQTEE-----NVMG 289
            G  +E  L   P     H  EN +K E+  +    EK   N   QL    +     NV  
Sbjct: 678  GHGEEQKLELNP-----HTVENVTKNEDSMTGIEVEKWTQNKKSQLTDHVKGDFSANVPE 732

Query: 290  VNKLLPEESDLYQSKT---------NGL--LSCLQHEKN----KYSIEESSVGRKPRKRM 334
              K    E D  ++K+         NG+  + CL  E N    K++IEE     +     
Sbjct: 733  AEKSKNSEVDKKRTKSPKLFVQTVRNGIKHVHCLPAETNVSFKKFNIEEFGKTLENNSYK 792

Query: 335  KLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVLRKVSHNTVSLMDH 394
             L + A+      + + + +   L  + N ++         S       + H++ S+++H
Sbjct: 793  FLKDTANHKNAMSSVATDMSCDHLKGRSNVLVFQQPGFNCSS-------IPHSSHSIINH 845

Query: 395  LLSV------PETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYESMASKEDFKS 448
              S+      P+T E   S E    +  Q ++  L+K+      + +  E++    +  S
Sbjct: 846  HASIHNEGDQPKTPENIPSKEPKDGSPVQPSLLSLMKDRRLTLEQVVAIEALTQLSEAPS 905

Query: 449  MKSFIGKSPNEYHIERRSS-------------REDLRSASEELKLSCQRTIPMTGKRTWP 495
              S   KS  +   E+R++             R+DL+  + + +       P   K++  
Sbjct: 906  ENSSPSKSEKDEESEQRTASLLNSCKAILYTVRKDLQDPNLQGEPPKLNHCPSLEKQS-- 963

Query: 496  YYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLLQSSLTET 555
              SC  +  +  +  +L  S         +  Q     H+ ++   + S  + +S+ ++ 
Sbjct: 964  --SCNTV-VFNGQTTTLSNSHI-----NSATNQASTKSHEYSKVTNSLSLFIPKSNSSKI 1015

Query: 556  NTESSSKEKLDSNSNCLSSVSAVEPTLMVIK--EPIIKDDKKIKSEELSRRGSEVISNTT 613
            +T  S  + + +  NC + +  + P    ++    ++   KK+ S++LS + +   +   
Sbjct: 1016 DTNKSIAQGIITLDNCSNDLHQLPPRNNEVEYCNQLLDSSKKLDSDDLSCQDA-THTQIE 1074

Query: 614  ED--TQLTSETQSLTGNKKKARGNLTKLNLTATSK---DGQEANNSAGKTIHRKACIAQQ 668
            ED  TQLT     +  N  K      K+  T TS    + Q+  N    TI +K   +  
Sbjct: 1075 EDVATQLTQLASIIKINYIKPEDK--KVESTPTSLVTCNVQQKYNQEKGTIQQKPPSSVH 1132

Query: 669  TFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNAKSSEREAYSPLELL 718
                  L K  N  +      P    + +K   V+ + ++R+ +  L  +
Sbjct: 1133 NNHGSSLTKQKNPTQKKTKSTPSRDRRKKKPTVVSYQENDRQKWEKLSYM 1182


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 38.1 bits (87), Expect = 0.073
 Identities = 40/172 (23%), Positives = 70/172 (40%), Gaps = 29/172 (16%)

Query: 21  NLQKRQAPGPGAAGGCGPEAGGCRENKQKRRMVARATPGRGEVESDKSVAASGAGKAARR 80
           +LQ+ QAP P AA         C + K++        PG+ E E  +   A         
Sbjct: 523 SLQREQAPSPPAA---------CEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSP 573

Query: 81  QVEGRRGPVSPSDSSDPRGLEAAKE--AELPLQTERHTKEKRKVTEASSDDPQPGLDLVR 138
           +V     PV+P +      L+A +E  A++  Q +RH  E +          Q  +  +R
Sbjct: 574 EVRSTE-PVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESK----------QEKMQQLR 622

Query: 139 KESLTSSESFQTVECLQSLGKESIIEGIKRRIRNKKLKSLENPPLKITENEA 190
            E L   E  + +   Q   KE  +  ++ R++    K++E    ++ E E+
Sbjct: 623 -EKLCQEEEEEILRLHQQ--KEQSLSSLRERLQ----KAIEEEEARMREEES 667


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 37.7 bits (86), Expect = 0.095
 Identities = 144/700 (20%), Positives = 284/700 (40%), Gaps = 111/700 (15%)

Query: 98   RGLEAAKEAELPL-QTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQS 156
            R +E+ K A + + Q +   KE     E+  +  + GL+L++        SF+  E L  
Sbjct: 708  RNVESLKCASMKMAQLQLENKE----LESEKEQLKKGLELLKA-------SFKKTERL-- 754

Query: 157  LGKESIIEGIKRRIRNKKL-KSLENPPLKITENEAT-QNIKVEFQDELYKNTP--KYSCN 212
               E   +G+   I N++L K+LEN   KI + E+  Q++++E Q  L KN    K S  
Sbjct: 755  ---EVSYQGLD--IENQRLQKTLENSNKKIQQLESELQDLEMENQT-LQKNLEELKISSK 808

Query: 213  ILSPEVENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEKS 272
             L    + N  L+          K    EN                    + LR  AE  
Sbjct: 809  RLEQLEKENKSLEQETSQLEKDKKQLEKEN--------------------KRLRQQAEIK 848

Query: 273  DTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLL--SCLQ----HEKNKYSIEESSV 326
            DT         EEN + +  L  E   L  SK  G+   SC++     ++NK  ++ +++
Sbjct: 849  DTT-------LEENNVKIGNLEKENKTL--SKEIGIYKESCVRLKELEKENKELVKRATI 899

Query: 327  GRKPRKRMKLSEKADETVTEMNFSNEYNK-----SELMLQENQMIADGKEAETKSPL--N 379
              K    ++  +   E +     +N+  K      ++ L + +++ D +  + +  L  +
Sbjct: 900  DIKTLVTLR-EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958

Query: 380  VLRKVSHNTVSLMDHLLSVPET-VEKETSSEHHVNA---VFQKTIEPLLKEETEN----A 431
             L      ++ + +  ++  E  +E+ T+    +       +K  E L + + E     +
Sbjct: 959  KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1018

Query: 432  SEPL-GYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQRTIPMTG 490
            S P+ G ++   +E  ++ +  +        +ER ++   L++  + LK   ++      
Sbjct: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT--LQAEKQALKTQLKQLETQNN 1076

Query: 491  KRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTD--SKLLL 548
                     A+I A   +  SL E +  L+ +Q +  QV+     +  T L +  ++LL+
Sbjct: 1077 NLQ------AQILALQRQTVSLQEQNTTLQ-TQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129

Query: 549  QSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIK------EPIIKDDKKIKSEELS 602
            Q S  E   ES  KE+ D  S   S +   E   ++ +      E +I     +KS   +
Sbjct: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKS---A 1186

Query: 603  RRGSEVISNTTED--TQLTSETQSLTGNKKKARGNLTKL-----NLTATSKDGQEANNSA 655
             +  EV     ED   QL  +   L   +K  +    K+     N    + + ++     
Sbjct: 1187 HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1246

Query: 656  GKTIHRKACIAQQTFIV----PDLVKILNTGRLTNFKIPLLKNK-SEKRKEVNAKSSERE 710
             +  H  + + ++T ++     +L  +LN  +L   ++    +K  E+ ++++  S++  
Sbjct: 1247 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306

Query: 711  AYSPLELLDNLSGADVRQNRS-KENVSMMMLGPQTLSIRN 749
              +  ELL  L G    +NR   + +  +ML  +TL  +N
Sbjct: 1307 --NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQN 1344


>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
          Length = 1441

 Score = 37.4 bits (85), Expect = 0.12
 Identities = 58/221 (26%), Positives = 84/221 (38%), Gaps = 52/221 (23%)

Query: 853  ILKAYEDDVLLIDVIQDD------PDLFGVSNEGELSFTSEVPKI----------SQEPN 896
            +LKA  D VLL +  Q D      P L     + E     E PK           S+E  
Sbjct: 204  LLKAQIDPVLLKNSSQQDNSSRESPSL----EDEETKKEEETPKQEEQKESEKMKSEEQP 259

Query: 897  VAGEHQSTDSKYMETPVKKEPSD--DLRELPVL------------------DCGWIKPDI 936
            +  E++ST +   ET VKKE  D  +L +LPV+                  +    K ++
Sbjct: 260  MDLENRSTANVLEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENV 319

Query: 937  CASNSAESEIKRDPKDVNTSLGE-VANETSENETLGDFSEQIKGSDLDEKHRFTDKVITK 995
                    E + DPKD  +S+ + VA E    E          G ++   H  T+K  + 
Sbjct: 320  KPIKVEVKECRADPKDTKSSMEKPVAQEPERIEF---------GGNIKSSHEITEK--ST 368

Query: 996  EEKENIYEVCKSKDSRNADFMVGECQFAVPVPKPLCLLVPP 1036
            EE E +    ++K       +     F  PV  PLC  V P
Sbjct: 369  EETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTP 409


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 37.4 bits (85), Expect = 0.12
 Identities = 79/431 (18%), Positives = 164/431 (38%), Gaps = 55/431 (12%)

Query: 98   RGLEAAKEAELPLQTERHTK-EKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQS 156
            R  E +K+ E+  +    T+ + +K +EA     Q  L    +E     + F+T+     
Sbjct: 766  RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQK-LTKQEEEKQILKQDFETLSQETK 824

Query: 157  LGKESIIEGIKRRIRNKKLKSLENPPLKITENEATQNIKVEFQDELYKNTPKYSCNILSP 216
            +  E +   I+  +   +   +E   L +TE    ++   +  D L  +  ++       
Sbjct: 825  IQHEELNNRIQTTVTELQKVKMEKEAL-MTELSTVKDKLSKVSDSLKNSKSEF------- 876

Query: 217  EVENN----SVLKL-RDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEK 271
            E EN     ++L L + C    H      EN L  + +       +   +KE   S   K
Sbjct: 877  EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE------LKKSLEKEKEASHQLK 930

Query: 272  SDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEESSVGRKPR 331
             + NS+ + L   +N +  N+   +E    Q   N L    + +K +    +  +     
Sbjct: 931  LELNSMQEQLIQAQNTLKQNE---KEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVL 987

Query: 332  KRMKLSEKADETVTEMN------------FSNEYNKSELMLQENQMIADGKEAETKSPLN 379
            ++ +L  K  + +T+                N Y KS+   ++ Q    G+E+E  +   
Sbjct: 988  QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQ 1047

Query: 380  VLRKVSH-----------------NTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEP 422
             L+ V                   N   L+  L +   T+E++++ +        K ++ 
Sbjct: 1048 DLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQD 1107

Query: 423  LLKEETENASEPLGYES-MASKEDFK-SMKSFIGKSPNEYHIERRSSREDLRSASEELKL 480
            + KE++    E +  +S +A  E+ K   +  I K   E    +  S +++ +  +  +L
Sbjct: 1108 IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQL 1167

Query: 481  SCQRTIPMTGK 491
              Q+ + + GK
Sbjct: 1168 LIQQKLELQGK 1178



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 104/502 (20%), Positives = 192/502 (38%), Gaps = 90/502 (17%)

Query: 257 ENFSKKENLRSLAEKSD---TNSIPQLLQTE---ENVMGVNKLLPEESDLYQSKTNGLLS 310
           +   K + L+    K D   T+S  +L   E   E     N  + +  DL++ K   L +
Sbjct: 111 KELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLAT 170

Query: 311 CLQHEKNKYSIEESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGK 370
            +   K+KY  E S           L E A++ VT +  + E NK   ++Q+  +  +  
Sbjct: 171 EIADIKSKYDEERS-----------LREAAEQKVTRL--TEELNKEATVIQD--LKTELL 215

Query: 371 EAETKSPLNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETEN 430
           +      + VL+K      +LMD++     T+E+E  SE              LK+E + 
Sbjct: 216 QRPGIEDVAVLKKELVQVQTLMDNM-----TLERERESEK-------------LKDECKK 257

Query: 431 ASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQRTIPMTG 490
               L  +  +S+     ++S + K P E  +  +  ++ L+S+  EL    Q       
Sbjct: 258 ----LQSQYASSEATISQLRSELAKGPQEVAVYVQELQK-LKSSVNELTQKNQTLTENLL 312

Query: 491 KRTWPYYSCARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLLQS 550
           K+   Y            +    E S   +  Q +  Q D+   Q  Q+ L+ S    ++
Sbjct: 313 KKEQDYTKL---------EEKHNEESVSKKNIQATLHQKDLDCQQL-QSRLSAS----ET 358

Query: 551 SLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEELSRRGSEVIS 610
           SL   + E S  EK ++       +S VE     +K        + + EE  + G ++ S
Sbjct: 359 SLHRIHVELS--EKGEATQKLKEELSEVETKYQHLKAEF--KQLQQQREEKEQHGLQLQS 414

Query: 611 NTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQEANNSAGKTIHRKACIAQQTF 670
              +      ET+   G   +A G L            ++   S+ K + ++  +A    
Sbjct: 415 EINQLHSKLLETERQLG---EAHGRLK-----------EQRQLSSEKLMDKEQQVADLQL 460

Query: 671 IVPDLVKIL--NTGRLTNFKIPLLKNKSEKRKEVNAKSSE----REAYSPLELL------ 718
            +  L + L       T  +  L K K + +++   + S     REA + LE +      
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520

Query: 719 --DNLSGADVRQNRSKENVSMM 738
               +   +    +SKEN+S++
Sbjct: 521 KDQKIQNLEALLQKSKENISLL 542


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 37.4 bits (85), Expect = 0.12
 Identities = 46/227 (20%), Positives = 90/227 (39%), Gaps = 25/227 (11%)

Query: 265 LRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEES 324
           LRS  +  D     Q+L+ E+ V   N+    + + Y+ +   L S L+ E  + +   S
Sbjct: 304 LRSKTQSLDEEQKQQILELEKKV---NEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 360

Query: 325 SVGRKPRKRMKLSEKA-------DETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSP 377
               +   +  ++ +A       D+   +M+   ++NK +L L+E++   +  + E ++ 
Sbjct: 361 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDK---NQLQQELENL 417

Query: 378 LNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGY 437
             VL    +     + HL  +    E+   S   + A  Q            ++ E L  
Sbjct: 418 KEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQ------------DSQERLQN 465

Query: 438 ESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQR 484
           E   +K+  K  K  +     E   ER+   E + +  EE KL   +
Sbjct: 466 ELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDK 512


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 37.4 bits (85), Expect = 0.12
 Identities = 46/227 (20%), Positives = 90/227 (39%), Gaps = 25/227 (11%)

Query: 265 LRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEES 324
           LRS  +  D     Q+L+ E+ V   N+    + + Y+ +   L S L+ E  + +   S
Sbjct: 424 LRSKTQSLDEEQKQQILELEKKV---NEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHS 480

Query: 325 SVGRKPRKRMKLSEKA-------DETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSP 377
               +   +  ++ +A       D+   +M+   ++NK +L L+E++   +  + E ++ 
Sbjct: 481 KTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDK---NQLQQELENL 537

Query: 378 LNVLRKVSHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGY 437
             VL    +     + HL  +    E+   S   + A  Q            ++ E L  
Sbjct: 538 KEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAEGLIASLQ------------DSQERLQN 585

Query: 438 ESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQR 484
           E   +K+  K  K  +     E   ER+   E + +  EE KL   +
Sbjct: 586 ELDLTKDSLKETKDALLNVEGELEQERQQHEETIAAMKEEEKLKVDK 632


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 37.4 bits (85), Expect = 0.12
 Identities = 72/364 (19%), Positives = 135/364 (37%), Gaps = 43/364 (11%)

Query: 263  ENLRSLAEKSDTNSIPQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIE 322
            E  R+  E+       +L + +E V+    +  EE    +++ +     +  E  +    
Sbjct: 1326 ERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKL 1385

Query: 323  ESSVGRKPRKRMKLSEKADETVTEMNFSNEYNKSELMLQENQMIADGKEAETKSPLNVLR 382
             + + R  R+R +L  + +E   E     E  +    LQ+     + +EAE +  +   +
Sbjct: 1386 RAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQ 1445

Query: 383  KV--SHNTVSLMDHLLSVPETVEKETSSEHHVNAVFQKTIEPLLKEETENASEPLGYESM 440
            KV    +     +H L     +  +   E H   + +  +E L ++           E  
Sbjct: 1446 KVVLQQDPQQAREHAL-----LRLQLEEEQHRRQLLEGELETLRRKLA-------ALEKA 1493

Query: 441  ASKEDFKSMKSF-IGKSPNEYHIER-RSSREDLRSASEELKLSCQRTIPMTGKRTWPYYS 498
              KE     +S  + K   E  I+R +SS E+   +  EL +   R              
Sbjct: 1494 EVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLE------------ 1541

Query: 499  CARISAWCWKKASLPESSYFLRGSQESCRQVDVPKHQTNQTHLTDSKLLLQSSLTETNTE 558
             AR+S   +  +   +   FLR            K Q  + +L      LQS +    TE
Sbjct: 1542 -ARLSELEFHNSKSSKELDFLREENH--------KLQLERQNLQLETRRLQSEINMAATE 1592

Query: 559  SSSKEKL---DSNSNCLSSVSAVEPTLMVIKEPIIKDDKKIKSEELSRR-GSEVISNTTE 614
            +     +   DS +N  S + ++E  L  +K   +  DK ++ +EL +R GS  +     
Sbjct: 1593 TRDLRNMTVADSGTNHDSRLWSLERELDDLKR--LSKDKDLEIDELQKRLGSVAVKREQR 1650

Query: 615  DTQL 618
            +  L
Sbjct: 1651 ENHL 1654


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 37.0 bits (84), Expect = 0.16
 Identities = 85/420 (20%), Positives = 157/420 (37%), Gaps = 56/420 (13%)

Query: 99   GLEAAKEAELPLQTERHTKEKRKVTEASSDDPQPGLDLVRKESLTSSESFQTVECLQSLG 158
            G E   + E P      T  +RK+T+   +  +  L L  K  L         E   + G
Sbjct: 1980 GKETLSKGETP-----ETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKG 2034

Query: 159  KESIIEGIKRRIRN-KKLKSLENPPLKITENEATQNIKVEFQDELYKNTPKYSCNILSPE 217
            K     G +  ++  +KL       +K  E+ + +  K+   +++ K   K + +     
Sbjct: 2035 KLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKL---NKILKALQKLTRDERKLT 2091

Query: 218  VENNSVLKLRDCNCFPHSKGCNDENNLPYKPDGGCMHVAENFSKKENLRSLAEKSDTNSI 277
             E   + K++        +   +++ L  K +          +K E   +  ++   N +
Sbjct: 2092 QEEIKMTKMKRALFVKERRLSIEQSKLDIK-EWDFSEKRSELTKDEKKLARKQRKLANKM 2150

Query: 278  PQLLQTEENVMGVNKLLPEESDLYQSKTNGLLSCLQHEKNKYSIEESSV----------- 326
             +++  EE      K+  EES L +  +  +L     ++ +  IEE  V           
Sbjct: 2151 RRMINKEE------KMTEEESKLARKHSEVILD----DEEEGGIEEEEVIPFLKRRWRKR 2200

Query: 327  -----GRKPRKRMKLSEKADETVTEMNFSNEYNK--SELMLQENQMIADGKEAETKSPLN 379
                 G KP++  K S + DE  +E +FS E      EL  QE+    + +E E +    
Sbjct: 2201 KEAKRGDKPKE--KFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEERE 2258

Query: 380  VLRKVSHNTVSLMDHLLSVPETVEKETSSE------------HHVNAVFQKTIEPLLKEE 427
               +V        +      + VEKE   +                 VF++  E + +EE
Sbjct: 2259 E-EEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEE 2317

Query: 428  TENASEPLGYESMASKEDFKSMKSFIGKSPNEYHIERRSSREDLRSASEELKLSCQRTIP 487
            TE+ S+    E   S E+    +  I K   ++ ++ +  R+ LR    E  LS  R +P
Sbjct: 2318 TESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQ-RRKSLR--GRERVLSILRGVP 2374



 Score = 31.6 bits (70), Expect = 6.8
 Identities = 20/83 (24%), Positives = 41/83 (49%), Gaps = 2/83 (2%)

Query: 586  KEPIIKDDKKIKSEELSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATS 645
            +E ++++DKK+K EE  +    ++S+ +++ Q   E +     +    G   +  +T   
Sbjct: 1506 EEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQ 1565

Query: 646  KDGQEANNSAGKTIHRKACIAQQ 668
            +  QE +  A   IHRK   A++
Sbjct: 1566 RHIQEEHKWA--RIHRKRARAEK 1586


>gi|169214154 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 737

 Score = 37.0 bits (84), Expect = 0.16
 Identities = 52/263 (19%), Positives = 95/263 (36%), Gaps = 40/263 (15%)

Query: 531 VPKHQTNQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPII 590
           +  + +  +  T S     S +T + T S+S     S S+  +S +    ++ +     I
Sbjct: 110 ITSNSSTSSSSTTSSTSTSSFITSSFTTSTSITSTSSTSSFTTSTATTSTSISITSTSSI 169

Query: 591 KDDKKIKSEELSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQE 650
                I S   S   +   SN+T  T  ++ T + T          T    T+T+     
Sbjct: 170 SSS--ITSTSTSTTSTS--SNSTTSTVTSTSTSTSTSTSTSTSSTFTSTTSTSTTSTSTT 225

Query: 651 ANNSAGK------TIHRKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNA 704
           + +++        T H+K C A  +  +  L  +++TG            K   R  V  
Sbjct: 226 STSTSATSSIRKLTPHQKQCGALASAFLFGLSLLVSTG-----------TKGLGRSLVTP 274

Query: 705 KSSEREAYSPLELLDNLSGA----DVRQNRSKENVSMMMLG---------------PQTL 745
           + S     +P      +  A    + RQ R  + V+    G               PQ L
Sbjct: 275 RPSPPPPLTPQAESGGVDAAPRAPETRQVRKVDGVNPAAAGPRGGATACSGVQSRRPQGL 334

Query: 746 SIRNSVTPVQASSDSFYNKKSYS 768
           ++R ++ P + S+D  +N  S S
Sbjct: 335 ALRATLLPAKRSADMRWNSGSCS 357


>gi|169213511 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 737

 Score = 37.0 bits (84), Expect = 0.16
 Identities = 52/263 (19%), Positives = 95/263 (36%), Gaps = 40/263 (15%)

Query: 531 VPKHQTNQTHLTDSKLLLQSSLTETNTESSSKEKLDSNSNCLSSVSAVEPTLMVIKEPII 590
           +  + +  +  T S     S +T + T S+S     S S+  +S +    ++ +     I
Sbjct: 110 ITSNSSTSSSSTTSSTSTSSFITSSFTTSTSITSTSSTSSFTTSTATTSTSISITSTSSI 169

Query: 591 KDDKKIKSEELSRRGSEVISNTTEDTQLTSETQSLTGNKKKARGNLTKLNLTATSKDGQE 650
                I S   S   +   SN+T  T  ++ T + T          T    T+T+     
Sbjct: 170 SSS--ITSTSTSTTSTS--SNSTTSTVTSTSTSTSTSTSTSTSSTFTSTTSTSTTSTSTT 225

Query: 651 ANNSAGK------TIHRKACIAQQTFIVPDLVKILNTGRLTNFKIPLLKNKSEKRKEVNA 704
           + +++        T H+K C A  +  +  L  +++TG            K   R  V  
Sbjct: 226 STSTSATSSIRKLTPHQKQCGALASAFLFGLSLLVSTG-----------TKGLGRSLVTP 274

Query: 705 KSSEREAYSPLELLDNLSGA----DVRQNRSKENVSMMMLG---------------PQTL 745
           + S     +P      +  A    + RQ R  + V+    G               PQ L
Sbjct: 275 RPSPPPPLTPQAESGGVDAAPRAPETRQVRKVDGVNPAAAGPRGGATACSGVQSRRPQGL 334

Query: 746 SIRNSVTPVQASSDSFYNKKSYS 768
           ++R ++ P + S+D  +N  S S
Sbjct: 335 ALRATLLPAKRSADMRWNSGSCS 357


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,432,351
Number of Sequences: 37866
Number of extensions: 2990163
Number of successful extensions: 9323
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 197
Number of HSP's that attempted gapping in prelim test: 8919
Number of HSP's gapped (non-prelim): 618
length of query: 1692
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1576
effective length of database: 13,855,062
effective search space: 21835577712
effective search space used: 21835577712
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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