Guide to the Human Genome
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Search of human proteins with 222352127

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222352127 sidekick 2 [Homo sapiens]
         (2172 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222352127 sidekick 2 [Homo sapiens]                               4389   0.0  
gi|119220552 sidekick 1 [Homo sapiens]                               2611   0.0  
gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken) ...   582   e-165
gi|75709184 contactin 3 [Homo sapiens]                                331   5e-90
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...   330   7e-90
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa...   323   1e-87
gi|7657361 contactin 6 [Homo sapiens]                                 311   6e-84
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            310   1e-83
gi|4827022 contactin 2 precursor [Homo sapiens]                       282   2e-75
gi|28373129 contactin 5 isoform short [Homo sapiens]                  275   4e-73
gi|7657359 contactin 5 isoform long [Homo sapiens]                    274   6e-73
gi|27894376 cell adhesion molecule with homology to L1CAM precur...   270   1e-71
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...   264   8e-70
gi|81158226 neuronal cell adhesion molecule isoform A precursor ...   264   8e-70
gi|81158224 neuronal cell adhesion molecule isoform B precursor ...   264   8e-70
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...   260   9e-69
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           251   5e-66
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo...   248   5e-65
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ...   248   6e-65
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s...   248   6e-65
gi|110349719 titin isoform N2-A [Homo sapiens]                        246   1e-64
gi|110349717 titin isoform novex-2 [Homo sapiens]                     246   1e-64
gi|110349713 titin isoform novex-1 [Homo sapiens]                     246   1e-64
gi|110349715 titin isoform N2-B [Homo sapiens]                        246   1e-64
gi|28373119 contactin 1 isoform 2 precursor [Homo sapiens]            245   3e-64
gi|28373117 contactin 1 isoform 1 precursor [Homo sapiens]            245   4e-64
gi|157311649 neogenin homolog 1 [Homo sapiens]                        243   2e-63
gi|28373126 contactin 4 isoform c precursor [Homo sapiens]            241   7e-63
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]            240   1e-62
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]           239   2e-62

>gi|222352127 sidekick 2 [Homo sapiens]
          Length = 2172

 Score = 4389 bits (11384), Expect = 0.0
 Identities = 2172/2172 (100%), Positives = 2172/2172 (100%)

Query: 1    MWGLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW 60
            MWGLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW
Sbjct: 1    MWGLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW 60

Query: 61   LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEK 120
            LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEK
Sbjct: 61   LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEK 120

Query: 121  HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGR 180
            HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGR
Sbjct: 121  HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGR 180

Query: 181  YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVAN 240
            YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVAN
Sbjct: 181  YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVAN 240

Query: 241  ARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA 300
            ARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA
Sbjct: 241  ARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA 300

Query: 301  YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 360
            YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR
Sbjct: 301  YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 360

Query: 361  NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
            NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV
Sbjct: 361  NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420

Query: 421  LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480
            LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS
Sbjct: 421  LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480

Query: 481  RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540
            RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT
Sbjct: 481  RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540

Query: 541  ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL 600
            ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL
Sbjct: 541  ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL 600

Query: 601  STVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARS 660
            STVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARS
Sbjct: 601  STVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARS 660

Query: 661  YQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQN 720
            YQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQN
Sbjct: 661  YQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQN 720

Query: 721  GILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS 780
            GILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS
Sbjct: 721  GILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS 780

Query: 781  KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEV 840
            KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEV
Sbjct: 781  KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEV 840

Query: 841  TMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGH 900
            TMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGH
Sbjct: 841  TMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGH 900

Query: 901  LSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTA 960
            LSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTA
Sbjct: 901  LSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTA 960

Query: 961  LTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGK 1020
            LTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGK
Sbjct: 961  LTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGK 1020

Query: 1021 TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTS 1080
            TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTS
Sbjct: 1021 TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTS 1080

Query: 1081 PPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR 1140
            PPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR
Sbjct: 1081 PPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR 1140

Query: 1141 SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPS 1200
            SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPS
Sbjct: 1141 SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPS 1200

Query: 1201 SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRS 1260
            SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRS
Sbjct: 1201 SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRS 1260

Query: 1261 AQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI 1320
            AQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI
Sbjct: 1261 AQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI 1320

Query: 1321 WQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR 1380
            WQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR
Sbjct: 1321 WQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTR 1380

Query: 1381 KGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTR 1440
            KGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTR
Sbjct: 1381 KGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTR 1440

Query: 1441 ELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA 1500
            ELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA
Sbjct: 1441 ELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA 1500

Query: 1501 PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNP 1560
            PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNP
Sbjct: 1501 PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNP 1560

Query: 1561 GATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE 1620
            GATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE
Sbjct: 1561 GATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE 1620

Query: 1621 AVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFL 1680
            AVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFL
Sbjct: 1621 AVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFL 1680

Query: 1681 AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSV 1740
            AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSV
Sbjct: 1681 AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSV 1740

Query: 1741 NVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFR 1800
            NVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFR
Sbjct: 1741 NVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFR 1800

Query: 1801 IRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE 1860
            IRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE
Sbjct: 1801 IRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE 1860

Query: 1861 ARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPA 1920
            ARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPA
Sbjct: 1861 ARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPA 1920

Query: 1921 QKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEM 1980
            QKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEM
Sbjct: 1921 QKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEM 1980

Query: 1981 MSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAE 2040
            MSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAE
Sbjct: 1981 MSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDLIPAE 2040

Query: 2041 SSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAY 2100
            SSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAY
Sbjct: 2041 SSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRAQAY 2100

Query: 2101 SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPG 2160
            SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPG
Sbjct: 2101 SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPG 2160

Query: 2161 SRAPIAGFSSFV 2172
            SRAPIAGFSSFV
Sbjct: 2161 SRAPIAGFSSFV 2172


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score = 2611 bits (6767), Expect = 0.0
 Identities = 1274/2172 (58%), Positives = 1636/2172 (75%), Gaps = 48/2172 (2%)

Query: 7    WTLLAL--HQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNN 64
            W LLAL  H +RA  AQDDV+PYFKTEP   Q+HLEGNRLVLTC+AEGSWPLEFKW+ ++
Sbjct: 84   WALLALQLHLLRAL-AQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDD 142

Query: 65   RELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSV 124
             ELT +S EY+Y+I SL +  AGFYRC+VRNRMGALLQR++EVQVAYMGSF + ++ ++V
Sbjct: 143  SELTTYSSEYKYIIPSLQKLDAGFYRCVVRNRMGALLQRKSEVQVAYMGSFMDTDQRKTV 202

Query: 125  SHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQ 184
            S G AA++    I S+P+PQVTWFR+G KI PS+RIAITLEN LVIL+T   DAG YYVQ
Sbjct: 203  SQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYYVQ 262

Query: 185  AVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPL 244
            AVN+KNG+NKTS  I L++    G  + +APTI++PP N SVVAG+SE TLEC+A+ARP+
Sbjct: 263  AVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASARPV 322

Query: 245  IKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304
              L + WK++GV ++ G+    RRLTI NPT +D G Y CEA L  S+       A+L +
Sbjct: 323  EDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFI 382

Query: 305  LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG 364
            +EPP F  EPE  I+AE+E+ VDI CQA GVP P++ WYKDA  +   +  R++    GG
Sbjct: 383  IEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLASGG 442

Query: 365  LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACE 424
            L+I  L P+D+G+FQCFA N  GE+QT TYL VT+IAP  T+ P+D+TV DGM+ +L CE
Sbjct: 443  LRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCE 502

Query: 425  TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
             SGAP+PAITW++   ILASGSV++PRF  LESG L I+P  I DAG YTC A N+ G  
Sbjct: 503  VSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSL 562

Query: 485  EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHP 544
             ASA L VW RT I  PP+D  VIKGT A++ CG THDPRV++RY+W+KD   L   S  
Sbjct: 563  NASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTS 622

Query: 545  RIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVE 604
            RI ++++GSL ISQTWSGDIG Y+C ++S GGNDSR A L V +LPH+P++ + + ++  
Sbjct: 623  RIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSH 682

Query: 605  RRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFR 664
              A+ L+W +PFDGNSP++ YI+E+SENN+PW V L++V P+ T VTV GL PAR+YQFR
Sbjct: 683  SHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFR 742

Query: 665  LCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILK 724
            +CAVN+VG+GQ+S +T R+ LPEEPP+APP+N++ASGRTNQSIM+QWQPPPE+  NG+L+
Sbjct: 743  VCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLR 802

Query: 725  GYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTE 784
            GYI+RY LAGLP  YQ +NIT  +VN  L+ DLIIWT YEI+VAAYN AGLGV+S  VTE
Sbjct: 803  GYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTE 862

Query: 785  WTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVT 844
            +TLQGVPT PP NV  EA NSTTI+F WN P  QFINGINQGYKL+AW  +  E VT+VT
Sbjct: 863  YTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVT 922

Query: 845  ARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFS 904
              P+F   +H G ++ LKKFT YFTSVLCFTTPGDGP STPQLV T ED PG VGHLSF+
Sbjct: 923  IAPDFH-GVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFT 981

Query: 905  EILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTY 964
            EILDTSLKVSWQEP EKNGI+TGY+ISWE Y R ++R+TH L + T EY++ GL++LTTY
Sbjct: 982  EILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTY 1041

Query: 965  TIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSIS 1024
            TI+VAA+T+ G G V++STISSGVPP+LPG P+NL ISNI PRS TLQFRPGYDGKTSIS
Sbjct: 1042 TIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSIS 1101

Query: 1025 RWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQ 1084
            RW+VE QVG +G+ EEW+ +++  NEPDA+ +E+P+L P+T Y FRM+QVNIVG SP S 
Sbjct: 1102 RWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSP 1161

Query: 1085 PSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGH 1144
             SR IQTLQAPPD+AP +V++RTASETSL LRW+PLP+ +YNGNPESVGY+IKY RSD  
Sbjct: 1162 SSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQ 1221

Query: 1145 GKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPT 1204
               ++ VV DR+ER++TIE+LEEW EY +Q+QAFNA+G+GPWS+ V GRTRESVPS+ P 
Sbjct: 1222 SSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPE 1281

Query: 1205 NVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLT 1264
            NVSA A +S+ +L+ W+ VPE D+NGL+LGYK++++ KD D +PR  +V GN ++SA L 
Sbjct: 1282 NVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLA 1341

Query: 1265 GLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPP 1324
            GL K+VLYE+QVLAFTRIG+G PS P ILERT DD PGPP+ ++FPEVR TSVR++WQPP
Sbjct: 1342 GLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPP 1401

Query: 1325 AAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG 1384
              PNGIIL YQI +RL +++ +T T   +  + RQ+TAT L PES Y+FR++A+TR+GWG
Sbjct: 1402 EEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWG 1461

Query: 1385 EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPS 1444
            E  EA V+TTEKR+RP PP   +V Q +V ARS+ L W PGSDG SP+RY+T+Q RELP 
Sbjct: 1462 EPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPR 1521

Query: 1445 GRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA 1504
            G W  +S+S+SH A++ +VDRL+PFTSYK R+KATNDIGDS+FS E+E++TTLQ  P E 
Sbjct: 1522 GEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEP 1581

Query: 1505 PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATW 1564
            P  +S TPHTT+SVLI+WQPP ++ +NG+L G+RI YREL YE   G   + + NP A  
Sbjct: 1582 PGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALH 1641

Query: 1565 AELTSMYSMRNLSRPSL-TQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVP 1623
            AELT+  S + ++  S  T  EL +L K+RRYE+ M+ YN +GE P+S P EVFVGEA P
Sbjct: 1642 AELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAP 1701

Query: 1624 TAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAEN 1683
              AP+NV V   TA+QL+VTW+PPP +SQNG+IQGYKIY+WEA   N TE++K LFL E 
Sbjct: 1702 AMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEP 1761

Query: 1684 SVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743
             V+LKNLT +T Y+VS++AFNAAGDGP+S P QG+T QAAP APS + FSE+T+T++NVS
Sbjct: 1762 VVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVS 1821

Query: 1744 WEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 1803
            W  P   NGIL+GYR+VYEP +PV GVSK+VTV+V+GN   WLKV+DL +GVTY FR++A
Sbjct: 1822 WGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA 1881

Query: 1804 KTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARP 1863
            +T TYGPE++AN+T GP EG+PG P   ++ + +S + + W+ G  G  P T YVIEARP
Sbjct: 1882 RTITYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARP 1941

Query: 1864 SDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKA 1923
            SDEGLWD+ +KDIP+  +SYT S+D L+ GV+Y+FRV+AVN+ G+G PS+PS +V AQ  
Sbjct: 1942 SDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVAVNEAGYGEPSNPSTAVSAQVE 2001

Query: 1924 NPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGHSEMMSL 1983
             PFYEEWWFL+V+AL  LI ILL+VF L++ GQ+KKY K   +G     G     E ++L
Sbjct: 2002 APFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY-KNCSTG----KGISTMEESVTL 2056

Query: 1984 DESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDV-TKYNDLIPAESS 2042
            D   F ALEL++R L+VK++F +KNG  TRSPPRPSPG LHYSDED+  KYN  +  ES 
Sbjct: 2057 DNGGFAALELSSRHLNVKSTFSKKNG--TRSPPRPSPGGLHYSDEDICNKYNGAVLTESV 2114

Query: 2043 SLTEKPSEISDSQGSDSEYEVDSNHQKAHSFVNHYISDPTYYNSWRRQQKGISRA--QAY 2100
            SL EK ++ S+S+ +DS+YE   +    HSFVNHY+SDPTYYNSW+R+ +G + A  +  
Sbjct: 2115 SLKEKSADASESEATDSDYE---DALPKHSFVNHYMSDPTYYNSWKRRAQGRAPAPHRYE 2171

Query: 2101 SYTESDSGEPDHTTVTNSTSTQQGSLFRPKASRTPTPQNPPNPPSQQSTLYRPPSSLAPG 2160
            +   S++G   H  +T  ++   G ++ P                             PG
Sbjct: 2172 AVAGSEAGAQLHPVITTQSA---GGVYTP---------------------------AGPG 2201

Query: 2161 SRAPIAGFSSFV 2172
            +R P+ GFSSFV
Sbjct: 2202 ARTPLTGFSSFV 2213


>gi|169217528 PREDICTED: similar to sidekick homolog 2 (chicken)
           [Homo sapiens]
          Length = 399

 Score =  582 bits (1500), Expect = e-165
 Identities = 295/314 (93%), Positives = 299/314 (95%), Gaps = 9/314 (2%)

Query: 242 RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 301
           RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY
Sbjct: 54  RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 113

Query: 302 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 361
           LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN
Sbjct: 114 LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 173

Query: 362 DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 421
           DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL
Sbjct: 174 DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVL 233

Query: 422 ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR 481
           ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR
Sbjct: 234 ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSR 293

Query: 482 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE 541
           GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIR +  + GA  G  
Sbjct: 294 GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRQL--RPGAPSGGH 351

Query: 542 -------SHPRIRL 548
                  SHP++RL
Sbjct: 352 WTYDSLYSHPQMRL 365



 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 78/254 (30%), Positives = 107/254 (42%), Gaps = 17/254 (6%)

Query: 340 ITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFA---RNAAGEVQTSTYLA 396
           I W KD  ++        R+     L I      D G ++C A    ++   V    YL+
Sbjct: 61  IIWKKDGVLLSGGISDHNRR-----LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 115

Query: 397 VTSIAPNITRGPLDSTVIDGMSVV-LACETSGAPRPAITWQKGERILASGSVQLPRFTPL 455
           V    P   + P      +   VV + C+  G P P+ITW K   ++     +L RF   
Sbjct: 116 VLE-PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE--KLTRFRQR 172

Query: 456 ESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWA-RTRITKPPQDQSVIKGTQAS 514
             G L IS     D G + C A N+ G  + S  L V +    IT+ P D +VI G    
Sbjct: 173 NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 232

Query: 515 MVCGVTHDPRVTIRYIWEKDGATL--GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVI 572
           + C  +  PR  I   W+K    L  G+   PR     +GSL IS T   D GTYTC   
Sbjct: 233 LACETSGAPRPAIT--WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 290

Query: 573 SAGGNDSRSAHLRV 586
           ++ G D  SA L V
Sbjct: 291 NSRGVDEASADLVV 304



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 61/249 (24%), Positives = 100/249 (40%), Gaps = 27/249 (10%)

Query: 75  RYMITSLDRTHAGFYRC--IVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVI 132
           R  I +   + AG+Y C  ++R+     + R   + V     F +  +    +  E  V 
Sbjct: 80  RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 139

Query: 133 RAPRIASFPQPQVTWFRDGR--KIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKN 190
              +    P P +TW++D    ++   +R     +  L I   V  D G +   A N   
Sbjct: 140 IPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARN-AA 198

Query: 191 GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHII 250
           G+ +TS  + +T          IAP I   P +++V+ G S V L C  +  P  +  I 
Sbjct: 199 GEVQTSTYLAVT---------SIAPNITRGPLDSTVIDGMS-VVLACETSGAP--RPAIT 246

Query: 251 WKK-DGVLLSGGIS------DHNRRLTIPNPTGSDAGYYECEAVLR---SSSVPSVVRGA 300
           W+K + +L SG +         +  L I     SDAG Y C A        +   +V  A
Sbjct: 247 WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWA 306

Query: 301 YLSVLEPPQ 309
              + +PPQ
Sbjct: 307 RTRITKPPQ 315



 Score = 36.6 bits (83), Expect = 0.28
 Identities = 44/164 (26%), Positives = 62/164 (37%), Gaps = 19/164 (11%)

Query: 433 ITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 492
           I W+K   +L+ G     R   + +      PT  SDAG Y C A        +   +V 
Sbjct: 61  IIWKKDGVLLSGGISDHNRRLTIPN------PTG-SDAGYYECEAVLR---SSSVPSVVR 110

Query: 493 WARTRITKPPQ----DQSVIKGTQASMV---CGVTHDPRVTIRYIWEKDGATLGTESHPR 545
            A   + +PPQ     +  I      +V   C     P  +I   W KD A +  E   R
Sbjct: 111 GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT--WYKDAAVVEVEKLTR 168

Query: 546 IRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
            R   +G L IS     D G + C   +A G    S +L V  +
Sbjct: 169 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI 212


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score =  331 bits (848), Expect = 5e-90
 Identities = 289/1017 (28%), Positives = 454/1017 (44%), Gaps = 63/1017 (6%)

Query: 26   PYFKTEPVRT--QVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRY------- 76
            P F  EP  +   V  E  ++ L C A G+    ++W  N  ++   S+E+RY       
Sbjct: 26   PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNGSDID-MSMEHRYKLNGGNL 84

Query: 77   -MITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQ-SVSHGEAAVIRA 134
             +I        G Y+C   N +G ++ R+ ++Q AY+ +F+   +   SV  G+  V+  
Sbjct: 85   VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREGQGVVLLC 144

Query: 135  PRIASFPQPQVTWFRDGRK--IPPSSRIAITLENTLVILSTVAP-DAGRYYVQAVNDKNG 191
                   +    W  +     +   SR  ++ E   + +S V P D G Y     +    
Sbjct: 145  GPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCVVTSMVTN 204

Query: 192  DNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIW 251
                  P  L + + G   +   P I +    T   A  S V LEC A   P+ +++  W
Sbjct: 205  ARVLGSPTPLVLRSDGVMGE-YEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQIN--W 261

Query: 252  KK-DGVLLSGGIS--DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 308
            ++ DG+  S  I     +  L IPN    DAG YEC  +  +S   +V RG      +P 
Sbjct: 262  RRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYEC--IAENSRGKNVARGRLTYYAKPH 319

Query: 309  --QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQ 366
              Q +K+ E      +E  +   C+A G P PS  W K+ A + +E+ T   Q  +G L 
Sbjct: 320  WVQLIKDVE----IAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERT---QIENGALT 372

Query: 367  ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVLACE 424
            IS L   D+GMFQC A N  G V +S  L V + AP+ ++ P+   V    G  V L C+
Sbjct: 373  ISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCK 432

Query: 425  TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
               +PR   +W+KG+  +        R + L  G L I+    +DAGTYTC+A N  G  
Sbjct: 433  PRASPRALSSWKKGDVSVQEHE----RISLLNDGGLKIANVTKADAGTYTCMAENQFGKA 488

Query: 485  EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE--- 541
              +  LVV   TRIT  P +  V  G    + C V HDP + I + W  +GA    +   
Sbjct: 489  NGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDG 548

Query: 542  SH-PRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL 600
            SH  ++    +G L I        G Y C V +   + S +A L VR  P  PE+    +
Sbjct: 549  SHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRGSPGPPEN--VKV 606

Query: 601  STVERRAINLTWTKPFDGNSPLIRYILEM-SENNAPW---TVLLASVDPKATSVTVKGLV 656
              +      L+W +  D +SP+I Y ++  +  +  W   T +   +D K  + TV  L 
Sbjct: 607  DEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTATVVELN 666

Query: 657  PARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPE 716
            P   Y+FR+ A N +G G+ S  +E+V   E  P  PP  V   G +   ++I W P PE
Sbjct: 667  PWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSELVITWDPVPE 726

Query: 717  SHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL--EDLIIWTNYEIEVAAYNSAG 774
              QNG   GY++ +   G+    Q   +T  D    +   E ++ ++ YE++V  YN+ G
Sbjct: 727  ELQNGEGFGYVVAFRPLGVTTWIQ-TVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKG 785

Query: 775  LGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEP 834
             G +S   T ++ +  PTV P  V A + +S+ I  +WN    +  NG   GY++  W  
Sbjct: 786  EGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNG 845

Query: 835  EQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDV 894
              +EE +        + S     + GLK    Y+T+V  + + G GP S    V T +  
Sbjct: 846  GGKEESSSKMKVAGNETSAR---LRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTP 902

Query: 895  PG-PVGHLSFSEILDTSLKVSWQE--PGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTL 951
            P  P G++ ++   DT + ++W++    E    +TGY++ +   ++ N +V +   N T 
Sbjct: 903  PSQPPGNVVWN-ATDTKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLN--TNKTS 959

Query: 952  EYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRS 1008
               V  L     Y IEV A T  G G  S+  I       +    +   ISN+ P S
Sbjct: 960  AELV--LPIKEDYIIEVKATTDGGDG-TSSEQIRIPRITSMDARGSTSAISNVHPMS 1013



 Score =  157 bits (396), Expect = 1e-37
 Identities = 111/376 (29%), Positives = 175/376 (46%), Gaps = 31/376 (8%)

Query: 1397 RDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSAS--- 1453
            R  P PP    V+ +++   +  LSW+ G D  SPV  Y+IQ R   S  W   +     
Sbjct: 595  RGSPGPPEN--VKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEV 652

Query: 1454 VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPH 1513
            +     +  V  L P+  Y+FRV A+N IG  E S  SE + T +A P+  P+ ++    
Sbjct: 653  IDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGG 712

Query: 1514 TTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSM 1573
            + + ++I W P  E+  NG   G+ + +R L   G+  +    + +P       T  Y  
Sbjct: 713  SRSELVITWDPVPEELQNGEGFGYVVAFRPL---GVTTWIQTVVTSPD------TPRYVF 763

Query: 1574 RNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVH 1633
            RN           +++  +  YE+++ VYN  GEGP SP   VF  E  PT AP  V  +
Sbjct: 764  RN-----------ESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSAN 812

Query: 1634 GATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLA--ENSVKLKNLT 1691
              ++++++V+W   P    NG + GY++ +W    G   E    + +A  E S +L+ L 
Sbjct: 813  SLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNG--GGKEESSSKMKVAGNETSARLRGLK 870

Query: 1692 GYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPN 1751
               AY  +V A+N+AG GP S      T++  PS P        T T V ++WE  +   
Sbjct: 871  SNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAME 930

Query: 1752 GILE--GYRLVYEPCS 1765
               E  GY++ Y   S
Sbjct: 931  NESEVTGYKVFYRTSS 946



 Score =  132 bits (332), Expect = 4e-30
 Identities = 119/433 (27%), Positives = 189/433 (43%), Gaps = 40/433 (9%)

Query: 977  GQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGV-V 1035
            G  S S+ +  +    PGPP N+ +  I   +  L ++ G D  + +  + ++A+    V
Sbjct: 582  GVDSVSSAADLIVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSV 641

Query: 1036 GEGEEWLLIHQLSNEPDARS--MEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ 1093
            G    W  +  +    D ++    V +LNP+  Y FR+   N +G   PS PS K++T +
Sbjct: 642  G----WQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEE 697

Query: 1094 APPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQ 1153
            A P++ P+ V+    S + L + W P+PE   NG  E  GY + + R  G    +  VV 
Sbjct: 698  AVPEVPPSEVNGGGGSRSELVITWDPVPEELQNG--EGFGYVVAF-RPLGVTTWIQTVVT 754

Query: 1154 DRVERDYTI--EDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALAT 1211
                  Y    E +  ++ Y V+V  +N  G GP+S      + E  P+  P+ VSA + 
Sbjct: 755  SPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSL 814

Query: 1212 TSSSMLVRWSEVPEADRNGLVLGYKVMY-----KEKDSDTQPRFWLVEGNSSRSAQLTGL 1266
            +SS + V W+ +P    NG +LGY+V Y     KE+ S        V GN + SA+L GL
Sbjct: 815  SSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMK----VAGNET-SARLRGL 869

Query: 1267 GKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAA 1326
               + Y   V A+   G G P    +   T    P  P G +      T V L W+   A
Sbjct: 870  KSNLAYYTAVRAYNSAGAG-PFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKA 928

Query: 1327 ------PNGIILAYQITHRLNTTTANT--ATVEVLAPSARQYT---------ATGLKPES 1369
                    G  + Y+ + + N    NT   + E++ P    Y            G   E 
Sbjct: 929  MENESEVTGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKEDYIIEVKATTDGGDGTSSEQ 988

Query: 1370 VYLFRITAQTRKG 1382
            + + RIT+   +G
Sbjct: 989  IRIPRITSMDARG 1001



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 111/476 (23%), Positives = 188/476 (39%), Gaps = 53/476 (11%)

Query: 1250 FWLVEGNSS-----RSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1304
            F  V G+SS     R+ QL   GKYV           +  G  S     +  +   PGPP
Sbjct: 551  FEKVGGSSSGDLMIRNIQLKHSGKYVCM---------VQTGVDSVSSAADLIVRGSPGPP 601

Query: 1305 MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTA---NTATVEVLAPSARQYT 1361
              +   E+  T+ +L W+     +  +++Y I  R   +      T   EV+       T
Sbjct: 602  ENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKTHTAT 661

Query: 1362 ATGLKPESVYLFRITAQTRKGWGEAA-EALVVTTEKRDRPQPPSRPMVQQEDVRARSVLL 1420
               L P   Y FR+ A  + G GE +  +  V TE+     PPS   V         +++
Sbjct: 662  VVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSE--VNGGGGSRSELVI 719

Query: 1421 SWEPGSDGLSPVRY--YTIQTRELPSGRWALHSASVSHNASSFIV--DRLKPFTSYKFRV 1476
            +W+P  + L       Y +  R L    W + +   S +   ++   + + P++ Y+ +V
Sbjct: 720  TWDPVPEELQNGEGFGYVVAFRPLGVTTW-IQTVVTSPDTPRYVFRNESIVPYSPYEVKV 778

Query: 1477 KATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLG 1536
               N+ G+  FS  + ++ + +  P  AP+ +S    +++ + + W        NG LLG
Sbjct: 779  GVYNNKGEGPFSPVT-TVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLLG 837

Query: 1537 FRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYE 1596
            + +RY                 N G      + M    N      T   L  L  +  Y 
Sbjct: 838  YEVRYW----------------NGGGKEESSSKMKVAGNE-----TSARLRGLKSNLAYY 876

Query: 1597 IRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDI 1656
              +  YN+ G GP S    V   +  P+  P NVV + AT T++ + WE         ++
Sbjct: 877  TAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWN-ATDTKVLLNWEQVKAMENESEV 935

Query: 1657 QGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRS 1712
             GYK+++  + + N+         AE  + +K       Y++ V A    GDG  S
Sbjct: 936  TGYKVFYRTSSQNNVQVLNTNKTSAELVLPIKE-----DYIIEVKATTDGGDGTSS 986



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 100/400 (25%), Positives = 169/400 (42%), Gaps = 21/400 (5%)

Query: 1100 PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHG-KTLSHV--VQDRV 1156
            P NV +   ++T+  L W    E + N +P  + Y I+       G +T++ V  V D  
Sbjct: 601  PENVKVDEITDTTAQLSWK---EGKDNHSPV-ISYSIQARTPFSVGWQTVTTVPEVIDGK 656

Query: 1157 ERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGPTNVSALATTSSS 1215
                T+ +L  W EY  +V A N IG G P   +   RT E+VP   P+ V+    + S 
Sbjct: 657  THTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVPEVPPSEVNGGGGSRSE 716

Query: 1216 MLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYVLYEV 1274
            +++ W  VPE  +NG   GY V ++     T  +  +   ++ R   +   +  Y  YEV
Sbjct: 717  LVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEV 776

Query: 1275 QVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQ--PPAAPNGIIL 1332
            +V  +   G+G  S    +    ++    P  +    + ++ + + W   P    NG +L
Sbjct: 777  KVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNTIPWKLSNGHLL 836

Query: 1333 AYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392
             Y++ +        +++   +A +       GLK    Y   + A    G G  +  + V
Sbjct: 837  GYEVRYWNGGGKEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNV 896

Query: 1393 TTEKRDRPQPPSRPMVQQEDVRARSVLLSWEP--GSDGLSPVRYYTIQTRELPSGRWALH 1450
            TT+K    QPP   +    D +   VLL+WE     +  S V  Y +  R        + 
Sbjct: 897  TTKKTPPSQPPGNVVWNATDTK---VLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVL 953

Query: 1451 SASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEE 1490
            +   ++  S+ +V  +K    Y   VKAT D GD   SE+
Sbjct: 954  N---TNKTSAELVLPIKE--DYIIEVKATTDGGDGTSSEQ 988



 Score = 58.2 bits (139), Expect = 9e-08
 Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 4/106 (3%)

Query: 1823 GAPGPP-GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
            G+PGPP  V +     +   + W  G     P+  Y I+AR      W   +  +P+ + 
Sbjct: 596  GSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQT-VTTVPEVID 654

Query: 1882 SYTFSMDI--LKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
              T +  +  L P V Y+FRV+A N  G G PS PS+ V  ++A P
Sbjct: 655  GKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVRTEEAVP 700


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
            precursor [Homo sapiens]
          Length = 2012

 Score =  330 bits (847), Expect = 7e-90
 Identities = 352/1291 (27%), Positives = 541/1291 (41%), Gaps = 135/1291 (10%)

Query: 41   GNRLVLTCMAEGSWPLEFKWLHN--------NRELTKFSLEYRYMITSLDRTHAGFYRCI 92
            G+++ L+C   G+   E  W  N        N  +T  + E   ++  + ++  G Y+C 
Sbjct: 328  GSQVSLSCSVTGTEDQELSWYRNGEILNPGKNVRITGINHE-NLIMDHMVKSDGGAYQCF 386

Query: 93   VRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF------PQPQVT 146
            VR      L  Q  VQV      E+G      +  E  V  A  ++        P P +T
Sbjct: 387  VRKDK---LSAQDYVQVV----LEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTIT 439

Query: 147  WFRDGRKIPP--SSRIA--ITLENTLV----ILSTVAPDAGRYYVQAVNDKNGDNKTSQP 198
            W  D   I    S RI+  IT E  +V    I S+   D G Y   A      +N     
Sbjct: 440  WTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTA------NNSAGVV 493

Query: 199  ITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL 258
            +     NV GPA       I P KN + +AG  +  + C     P   +   W K+  LL
Sbjct: 494  LYQARINVRGPAS------IRPMKNITAIAGR-DTYIHCRVIGYPYYSIK--WYKNSNLL 544

Query: 259  SGG----ISDHNRRLTIPNPTGS-DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKE 313
                     ++N  L + +     D G Y C  +++     S  +  +++V  PP F+ +
Sbjct: 545  PFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQL--STSQSVHVTVKVPP-FI-Q 600

Query: 314  PERHITAEMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEK-LTRFRQRNDGGLQISGLV 371
            P       + + V IPC    G  P +ITW KD   +     +T         L+IS L 
Sbjct: 601  PFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLS 660

Query: 372  PDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRP 431
                G + C ARN A  V+  + L V  + P     P D   I G +V+L C   G P P
Sbjct: 661  LMHNGNYTCIARNEAAAVEHQSQLIVR-VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVP 719

Query: 432  AITWQ--KGERILASGSVQLP-RFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEA-S 487
             I W+  KG  +     + L  R   L +GSLLI      D+G Y C  +N  G D + S
Sbjct: 720  TIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKS 779

Query: 488  ADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE------ 541
              L V     IT  P      +G +  M C    +  + +R  WEK+   +  E      
Sbjct: 780  MYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVR--WEKEDRIINPEMARYLV 837

Query: 542  SHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLS 601
            S   +  +   +L I  T   D G ++C  I++ G D     L V++ P  PE     + 
Sbjct: 838  STKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDPPE---IEIK 894

Query: 602  TVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVD--PKATSVTVKGLVPAR 659
             V+ R I L WT  FDGNSP+  Y +E    +  W     + D  P+  S T+  + P+ 
Sbjct: 895  DVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSS 954

Query: 660  SYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQ 719
            +Y  R+ A N +GK + S +   ++  E  P  PPQ V     ++QSI + W+ P +  Q
Sbjct: 955  TYSIRMYAKNRIGKSEPSNELT-ITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQ 1013

Query: 720  NGILKGYIIRYCLAGLPVGYQFKNI---TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLG 776
            NGI++GY I Y        +QF  I   T  D     L++L  +T Y + V A N AG G
Sbjct: 1014 NGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTG 1073

Query: 777  VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQ 836
              S ++   TL+ VP+ PP NV A AT+  +I  +W+  S + +NGI QG+++I W    
Sbjct: 1074 PSSQEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLM 1133

Query: 837  EEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPG 896
            + E+  +      Q S+    + GL+K+T Y   VL FT  GDG RS     RT EDVPG
Sbjct: 1134 DGELGEIKNITTTQPSLE---LDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPG 1190

Query: 897  PVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVT 956
            P   +  +    + + VSW  P + NGI+  Y +       T        P+ +  YR+ 
Sbjct: 1191 PPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTVFCSHPYPTVISEFEASPD-SFSYRIP 1249

Query: 957  GLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPG 1016
             L+    Y++ V A+TS G+G  S+  I+  V P    P   L  S              
Sbjct: 1250 NLSRNRQYSVWVVAVTSAGRGN-SSEIIT--VEPLAKAPARILTFSG------------- 1293

Query: 1017 YDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD--LNPFTCYSFRMRQV 1074
                T  + W+ +  +     G+    +  + +     S+   D   + F+  SF +R V
Sbjct: 1294 ----TVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTV 1349

Query: 1075 N---------IVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY 1125
                      I   +  S        +Q PPD     VS  T+S  S+ L W+P      
Sbjct: 1350 KAEDSGYYSCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSS--SITLSWLP----GD 1403

Query: 1126 NGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGP 1185
            NG     GY ++Y  S+ + +          ER Y +E+L+  T Y+  + A N +G G 
Sbjct: 1404 NGGSSIRGYILQY--SEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGR 1461

Query: 1186 WSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSD 1245
             S+ +  +T    P    +    L  + ++  VR + +   D    +  + + Y+   + 
Sbjct: 1462 ISEIIEAKTLGKEPQF--SKEQELFASINTTRVRLNLIGWNDGGCPITSFTLEYRPFGTT 1519

Query: 1246 TQPRFWLVEGNSSRSAQLTGLGK-YVLYEVQ 1275
                 W        +AQ T L K Y+LY++Q
Sbjct: 1520 V----W-------TTAQRTSLSKSYILYDLQ 1539



 Score =  195 bits (496), Expect = 4e-49
 Identities = 184/697 (26%), Positives = 299/697 (42%), Gaps = 73/697 (10%)

Query: 930  ISWEEYNRT-NTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISS-- 986
            + WE+ +R  N  +  YL +     +  G   ++T  +++     +  G  S   I+S  
Sbjct: 819  VRWEKEDRIINPEMARYLVST----KEVGEEVIST--LQILPTVREDSGFFSCHAINSYG 872

Query: 987  ------GVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEE 1040
                   +  + P  P  + I ++  R++TL++  G+DG + I+ + +E +     + + 
Sbjct: 873  EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECK----NKSDS 928

Query: 1041 WLLIHQLSN-EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA 1099
            W    +  +  P   S  + D++P + YS RM   N +G S PS     I   +A PD  
Sbjct: 929  WDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSN-ELTITADEAAPDGP 987

Query: 1100 PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD 1159
            P  V L   S  S+ + W    +   NG     GY+I Y      G    +++      D
Sbjct: 988  PQEVHLEPISSQSIRVTWKAPKKHLQNGIIR--GYQIGYREYSTGGNFQFNIISVDTSGD 1045

Query: 1160 ---YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSM 1216
               YT+++L ++T+Y + VQA N  G+GP SQ ++  T E VPS  P NV A+AT+  S+
Sbjct: 1046 SEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPESI 1105

Query: 1217 LVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQV 1276
             + WS + +   NG++ G++V+Y     D +         +  S +L GL KY  Y +QV
Sbjct: 1106 SISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQV 1165

Query: 1277 LAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQI 1336
            LAFTR GDG  S   I  RT +DVPGPP G+       + V + W PP   NGII  Y +
Sbjct: 1166 LAFTRAGDGVRSE-QIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKYTV 1224

Query: 1337 --THRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTT 1394
              +H   T  +        +P +  Y    L     Y   + A T  G G ++E + V  
Sbjct: 1225 FCSHPYPTVISEFEA----SPDSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITV-- 1278

Query: 1395 EKRDRPQPPSRPMVQQEDVRA---RSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHS 1451
                  + P+R +     V     + ++L  +   D  SP   +   +   PS       
Sbjct: 1279 --EPLAKAPARILTFSGTVTTPWMKDIVLPCKAVGDP-SPAVKWMKDSNGTPSLVTIDGR 1335

Query: 1452 ASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVT 1511
             S+  N  SFI+  +K   S  +   A N+ G  E     +    +Q  PD+    L+V+
Sbjct: 1336 RSIFSN-GSFIIRTVKAEDSGYYSCIANNNWGSDEIILNLQ----VQVPPDQPR--LTVS 1388

Query: 1512 PHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMY 1571
              T++S+ + W P   D     + G+ ++Y E   E    F +                 
Sbjct: 1389 KTTSSSITLSWLP--GDNGGSSIRGYILQYSEDNSEQWGSFPI----------------- 1429

Query: 1572 SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG 1608
                   PS   Y L+NL     Y+  ++  N VG G
Sbjct: 1430 ------SPSERSYRLENLKCGTWYKFTLTAQNGVGPG 1460



 Score =  176 bits (445), Expect = 3e-43
 Identities = 110/359 (30%), Positives = 174/359 (48%), Gaps = 22/359 (6%)

Query: 1401 QPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRW--ALHSASVSHNA 1458
            +PP  P ++ +DV+AR++ L W  G DG SP+  Y I+ +   S  W  A  +  VS   
Sbjct: 884  EPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKN-KSDSWDSAQRTKDVSPQL 942

Query: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSV 1518
            +S  +  + P ++Y  R+ A N IG SE S E  ++T  +AAPD  P  + + P ++ S+
Sbjct: 943  NSATIIDIHPSSTYSIRMYAKNRIGKSEPSNEL-TITADEAAPDGPPQEVHLEPISSQSI 1001

Query: 1519 LIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSR 1578
             + W+ P +   NGI+ G++I YRE    G   F +  ++  G +               
Sbjct: 1002 RVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEV------------- 1048

Query: 1579 PSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATAT 1638
                 Y LDNLNK  +Y + +   N  G GPSS        E VP+  P NV     +  
Sbjct: 1049 -----YTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDVPSYPPENVQAIATSPE 1103

Query: 1639 QLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMV 1698
             + ++W     ++ NG +QG+++ +W          +K +   + S++L  L  YT Y +
Sbjct: 1104 SISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSI 1163

Query: 1699 SVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGY 1757
             V AF  AGDG RS     +T++  P  P+ VK +  + + V VSW  P   NGI+  Y
Sbjct: 1164 QVLAFTRAGDGVRSEQIFTRTKEDVPGPPAGVKAAAASASMVFVSWLPPLKLNGIIRKY 1222



 Score =  160 bits (405), Expect = 1e-38
 Identities = 318/1528 (20%), Positives = 561/1528 (36%), Gaps = 161/1528 (10%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTH 85
            PY  T  V  Q  + GN  V  C+   S       +   ++        R++ITS    +
Sbjct: 125  PY--TVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITSTGALY 182

Query: 86   AGF---------YRCIVRNRMGALLQRQTEVQVAYMG------SFEEGEKHQSVSHGEAA 130
                        YRCI R+R     ++    ++          S  +G  H+    G+  
Sbjct: 183  IKDVQNEDGLYNYRCITRHRYTGETRQSNSARLFVSDPANSAPSILDGFDHRKAMAGQRV 242

Query: 131  VIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKN 190
             +    +   P+P   W +D   +  S R   T+  T +++  + P     YV  V+++ 
Sbjct: 243  ELPCKALGH-PEPDYRWLKDNMPLELSGRFQKTV--TGLLIENIRPSDSGSYVCEVSNRY 299

Query: 191  GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHII 250
            G  K    + +          P+  TI  P K  S V   S+V+L C        +L   
Sbjct: 300  GTAKVIGRLYVK--------QPLKATIS-PRKVKSSVG--SQVSLSCSVTGTEDQELS-- 346

Query: 251  WKKDGVLLSGG-----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 305
            W ++G +L+ G        ++  L + +   SD G Y+C            VR   LS  
Sbjct: 347  WYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQC-----------FVRKDKLSAQ 395

Query: 306  EPPQFVKEP--ERHITAEMEKVVD------IPCQAKGVPPPSITWYKDAAVVEVEKLTRF 357
            +  Q V E    + I+A  EKVV       + C  KG P P+ITW  D   +      R 
Sbjct: 396  DYVQVVLEDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRI 455

Query: 358  RQR--NDGG----LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS 411
             Q   ++G     L IS     D G+++C A N+AG V     + V    P   R   + 
Sbjct: 456  SQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRG--PASIRPMKNI 513

Query: 412  TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS-DA 470
            T I G    + C   G P  +I W K   +L     Q+       +G+L +S      D 
Sbjct: 514  TAIAGRDTYIHCRVIGYPYYSIKWYKNSNLLPFNHRQVAFEN---NGTLKLSDVQKEVDE 570

Query: 471  GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYI 530
            G YTC       +  + +  V        +P +      G +  + C V     + I   
Sbjct: 571  GEYTCNVLVQPQLSTSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVSGD-LPITIT 629

Query: 531  WEKDGATL-GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
            W+KDG  + G+       +D   SL IS       G YTC   +        + L VR  
Sbjct: 630  WQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVP 689

Query: 590  PHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKAT- 648
            P     P      +  +A+ L  +       P+   + + S+          +++ +   
Sbjct: 690  PKFVVQP-RDQDGIYGKAVILNCSAE---GYPVPTIVWKFSKGAGVPQFQPIALNGRIQV 745

Query: 649  ----SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTN 704
                S+ +K +V   S  +     NDVG          V +P    + P   +   G+  
Sbjct: 746  LSNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKK 805

Query: 705  QS---------IMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLE 755
            +          I+++W+      ++ I+   + RY ++   VG +   I+   +   + E
Sbjct: 806  EMSCTAHGEKPIIVRWEK-----EDRIINPEMARYLVSTKEVGEEV--ISTLQILPTVRE 858

Query: 756  DLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAP 815
            D   ++ + I     NS G       + + T+Q  P  P   +      + T+R+T    
Sbjct: 859  DSGFFSCHAI-----NSYG---EDRGIIQLTVQEPPDPPEIEIKDVKARTITLRWTMGFD 910

Query: 816  SPQFING--INQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLC 873
                I G  I    K  +W+  Q  +        +    ++   +  +   + Y   +  
Sbjct: 911  GNSPITGYDIECKNKSDSWDSAQRTK--------DVSPQLNSATIIDIHPSSTYSIRMYA 962

Query: 874  FTTPGDGPRSTPQLVRTHEDVP-GPVGHLSFSEILDTSLKVSWQEPGE--KNGILTGYRI 930
                G    S    +   E  P GP   +    I   S++V+W+ P +  +NGI+ GY+I
Sbjct: 963  KNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIRGYQI 1022

Query: 931  SWEEYNRTNTRVTHYLPNVTLE-----YRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
             + EY+ T       + +V        Y +  L   T Y + V A    G G  S   I+
Sbjct: 1023 GYREYS-TGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIIT 1081

Query: 986  SGVPPELPGPPTNLGISNIGPRSVTLQFRP-GYDGKTSISRWLVEAQVGVVGEGEEWLLI 1044
            + +      PP N+      P S+++ +     +    I +         + +GE   + 
Sbjct: 1082 TTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLMDGELGEIK 1141

Query: 1045 HQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP--SRKIQTLQAPPDMAPAN 1102
            +  + +P   S+E+  L  +T YS ++      G    S+   +R  + +  PP    A 
Sbjct: 1142 NITTTQP---SLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVPGPP----AG 1194

Query: 1103 VSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTI 1162
            V    AS + +++ W  LP ++ NG    +  K     S  +   +S          Y I
Sbjct: 1195 VKAAAASASMVFVSW--LPPLKLNG----IIRKYTVFCSHPYPTVISEFEASPDSFSYRI 1248

Query: 1163 EDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSE 1222
             +L    +Y V V A  + G G  S+ +        P+        + T S ++   W +
Sbjct: 1249 PNLSRNRQYSVWVVAVTSAGRGNSSEIITVEPLAKAPAR-------ILTFSGTVTTPWMK 1301

Query: 1223 VPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA---F 1279
                    +      +   KDS+  P    ++G  S    +   G +++  V+      +
Sbjct: 1302 DIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS----IFSNGSFIIRTVKAEDSGYY 1357

Query: 1280 TRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR 1339
            + I + +     I+      VP     +   +  ++S+ L W P       I  Y + + 
Sbjct: 1358 SCIANNNWGSDEIILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYS 1417

Query: 1340 LNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VVTTEKRD 1398
             + +    +    ++PS R Y    LK  + Y F +TAQ   G G  +E +   T  K  
Sbjct: 1418 EDNSEQWGSFP--ISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEP 1475

Query: 1399 RPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNA 1458
            +              R R  L+ W   +DG  P+  +T++ R  P G     +A  +  +
Sbjct: 1476 QFSKEQELFASINTTRVRLNLIGW---NDGGCPITSFTLEYR--PFGTTVWTTAQRTSLS 1530

Query: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSE 1486
             S+I+  L+  T Y+ +++  N  G +E
Sbjct: 1531 KSYILYDLQEATWYELQMRVCNSAGCAE 1558



 Score =  137 bits (344), Expect = 1e-31
 Identities = 163/659 (24%), Positives = 270/659 (40%), Gaps = 76/659 (11%)

Query: 1292 ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTAT-V 1350
            I++ T+ + P PP  I   +V+  ++ L W      N  I  Y I  +  + + ++A   
Sbjct: 877  IIQLTVQEPPDPPE-IEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRT 935

Query: 1351 EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ 1410
            + ++P     T   + P S Y  R+ A+ R G  E +  L +T ++     PP    V  
Sbjct: 936  KDVSPQLNSATIIDIHPSSTYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQE--VHL 993

Query: 1411 EDVRARSVLLSWEPGSDGLSP--VRYYTIQTRELPSG---RWALHSASVSHNASSFIVDR 1465
            E + ++S+ ++W+     L    +R Y I  RE  +G   ++ + S   S ++  + +D 
Sbjct: 994  EPISSQSIRVTWKAPKKHLQNGIIRGYQIGYREYSTGGNFQFNIISVDTSGDSEVYTLDN 1053

Query: 1466 LKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPP 1525
            L  FT Y   V+A N  G    S+E  + TTL+  P   P  +     +  S+ I W   
Sbjct: 1054 LNKFTQYGLVVQACNRAGTGPSSQEIIT-TTLEDVPSYPPENVQAIATSPESISISWSTL 1112

Query: 1526 AEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLS--RPSLTQ 1583
            +++ +NGIL GFR+ Y   L +G  G                     ++N++  +PSL  
Sbjct: 1113 SKEALNGILQGFRVIYWANLMDGELG--------------------EIKNITTTQPSL-- 1150

Query: 1584 YELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVT 1643
             ELD L K+  Y I++  +   G+G  S        E VP   P  V    A+A+ + V+
Sbjct: 1151 -ELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKAAAASASMVFVS 1208

Query: 1644 WEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAEN---SVKLKNLTGYTAYMVSV 1700
            W PP     NG I+ Y ++        ++E     F A     S ++ NL+    Y V V
Sbjct: 1209 WLPPL--KLNGIIRKYTVFCSHPYPTVISE-----FEASPDSFSYRIPNLSRNRQYSVWV 1261

Query: 1701 AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLV 1760
             A  +AG G  S     +    AP+    + FS   TT          +   I+   + V
Sbjct: 1262 VAVTSAGRGNSSEIITVEPLAKAPAR--ILTFSGTVTTP---------WMKDIVLPCKAV 1310

Query: 1761 YEPCSPV------DGVSKIVTVD----VKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
             +P   V      +G   +VT+D    +  N    ++    AE   Y +   A       
Sbjct: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVK-AEDSGY-YSCIANNNWGSD 1368

Query: 1811 EIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWD 1870
            EI  N+     +  P  P + +    SS+I + W  GD G   I  Y+++    +   W 
Sbjct: 1369 EIILNLQV---QVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQWG 1425

Query: 1871 ILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANPFYEE 1929
                  P   S  ++ ++ LK G  Y F + A N  G G  S   ++    K   F +E
Sbjct: 1426 ----SFPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKE 1480



 Score =  134 bits (337), Expect = 1e-30
 Identities = 155/614 (25%), Positives = 238/614 (38%), Gaps = 46/614 (7%)

Query: 6   IWTL-LALHQIRAARAQDDV--SPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW-- 60
           +W L L+L Q  A    +D+  S YF    ++  V       ++ C A G  P+  +W  
Sbjct: 1   MWILALSLFQSFANVFSEDLHSSLYFVNASLQEVVFASTTGTLVPCPAAGIPPVTLRWYL 60

Query: 61  --------------LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTE 106
                         +H N  L  F        T +   H   Y C   N  G +  +   
Sbjct: 61  ATGEEIYDVPGIRHVHPNGTLQIFPFPPSSFSTLI---HDNTYYCTAENPSGKIRSQDVH 117

Query: 107 VQVAYMGSFEEGEKHQSVSHGEAAVIRA--PRIASFPQPQVTWFRDGRKIPPSSRIAITL 164
           ++      +    + Q    G  AV +   P         V+W +D   +   SR  IT 
Sbjct: 118 IKAVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEAYITVVSWEKDTVSLVSGSRFLITS 177

Query: 165 ENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNT 224
              L I   V  + G Y  + +       +T Q  +  +  V  PA+  AP+I+    + 
Sbjct: 178 TGALYI-KDVQNEDGLYNYRCITRHRYTGETRQSNSARLF-VSDPANS-APSILDGFDHR 234

Query: 225 SVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL--SGGISDHNRRLTIPNPTGSDAGYY 282
             +AG   V L C A   P  +    W KD + L  SG        L I N   SD+G Y
Sbjct: 235 KAMAG-QRVELPCKALGHP--EPDYRWLKDNMPLELSGRFQKTVTGLLIENIRPSDSGSY 291

Query: 283 ECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW 342
            CE   R  +   + R   L V +P +    P R + + +   V + C   G     ++W
Sbjct: 292 VCEVSNRYGTAKVIGR---LYVKQPLKATISP-RKVKSSVGSQVSLSCSVTGTEDQELSW 347

Query: 343 YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP 402
           Y++  ++   K  R    N   L +  +V  D G +QCF R      Q    + +    P
Sbjct: 348 YRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLEDGTP 407

Query: 403 NITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLES---G 458
            I     +  V     V L C   G P P ITW    + IL  GS ++ +    E     
Sbjct: 408 KIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVS 467

Query: 459 SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCG 518
            L IS + + D G Y C A NS GV    A + V     I +P ++ + I G    + C 
Sbjct: 468 YLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPASI-RPMKNITAIAGRDTYIHCR 526

Query: 519 VTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSG-DIGTYTCRV-ISAGG 576
           V   P  +I+  W K+ + L   +H ++  + NG+L +S      D G YTC V +    
Sbjct: 527 VIGYPYYSIK--WYKN-SNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQL 583

Query: 577 NDSRSAHLRVRQLP 590
           + S+S H+ V+  P
Sbjct: 584 STSQSVHVTVKVPP 597



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 75/283 (26%), Positives = 124/283 (43%), Gaps = 18/283 (6%)

Query: 517  CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGG 576
            C    DP   ++++ + +G         R  +  NGS  I    + D G Y+C   +  G
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366

Query: 577  NDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAP- 635
            +D    +L+V Q+P  P+ P  T+S     +I L+W    +G S +  YIL+ SE+N+  
Sbjct: 1367 SDEIILNLQV-QVP--PDQPRLTVSKTTSSSITLSWLPGDNGGSSIRGYILQYSEDNSEQ 1423

Query: 636  WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ 695
            W      + P   S  ++ L     Y+F L A N VG G+ S+  E  +L +EP  +  Q
Sbjct: 1424 WGSF--PISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQ 1481

Query: 696  NVIASGRTN--QSIMIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNITDADVNNL 752
             + AS  T   +  +I W      +  G  +  + + Y   G  V    +  + +   + 
Sbjct: 1482 ELFASINTTRVRLNLIGW------NDGGCPITSFTLEYRPFGTTVWTTAQRTSLS--KSY 1533

Query: 753  LLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPP 795
            +L DL   T YE+++   NSAG     +        G  T+PP
Sbjct: 1534 ILYDLQEATWYELQMRVCNSAGCAEKQANFATLNYDG-STIPP 1575



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 54/221 (24%), Positives = 91/221 (41%), Gaps = 23/221 (10%)

Query: 1622 VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWE---AQRGNLTERVKTL 1678
            VP   PR + V   T++ + ++W P   D+    I+GY + + E    Q G+       +
Sbjct: 1378 VPPDQPR-LTVSKTTSSSITLSWLPG--DNGGSSIRGYILQYSEDNSEQWGSFP-----I 1429

Query: 1679 FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS-APSSVKFSELTT 1737
              +E S +L+NL   T Y  ++ A N  G G  S   + +T    P  +     F+ + T
Sbjct: 1430 SPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQFSKEQELFASINT 1489

Query: 1738 TSVN---VSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
            T V    + W     P   +  + L Y P     G +   T      S  ++ + DL E 
Sbjct: 1490 TRVRLNLIGWNDGGCP---ITSFTLEYRPF----GTTVWTTAQRTSLSKSYI-LYDLQEA 1541

Query: 1795 VTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
              Y  ++R        E +AN  T   +G+  PP +  +V+
Sbjct: 1542 TWYELQMRVCNSAGCAEKQANFATLNYDGSTIPPLIKSVVQ 1582


>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
            sapiens]
          Length = 2113

 Score =  323 bits (828), Expect = 1e-87
 Identities = 337/1312 (25%), Positives = 546/1312 (41%), Gaps = 145/1312 (11%)

Query: 41   GNRLVLTCMAEGSWPLEFKWLHNNR-ELTKFSLEYR------YMITSLDRTHAGFYRCIV 93
            G+ ++L+C   GS     +W  N    L   ++  R       +ITS  ++H+G Y+C  
Sbjct: 389  GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF- 447

Query: 94   RNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF------PQPQVTW 147
                 A  + QT    A + + E+G      S  E  V    + +        P P VTW
Sbjct: 448  -----ATRKAQTAQDFAII-ALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW 501

Query: 148  FRDGRKIPP-----SSRIAITLENTLVILSTVAP---DAGRYYVQAVNDKNGDNKTSQPI 199
              D   I       +++  ++   T+  ++   P   D G Y   A N        ++  
Sbjct: 502  ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI- 560

Query: 200  TLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLS 259
                 NV GP        I   +N + VAG  +  + C     P   +   W KD +LL 
Sbjct: 561  -----NVRGPPS------IRAMRNITAVAGR-DTLINCRVIGYPYYSIK--WYKDALLLP 606

Query: 260  GGISDHNRRLTIPNPT--------GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311
                D++R++   N T        G D G Y C  +++     S+ +  +++V  PP   
Sbjct: 607  ----DNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL--SISQSVHVAVKVPPLI- 659

Query: 312  KEPERHITAEMEKVVDIPCQ-AKGVPPPSITWYKDAAVV-EVEKLTRFRQRNDGGLQISG 369
             +P     A + +++ IPC  + G  P  ITW KD  V+     +T   +     LQIS 
Sbjct: 660  -QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISS 718

Query: 370  LVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAP 429
            +     G + C A NAA  V     L V  + P     P +   I G + VL C   G P
Sbjct: 719  VSLKHNGNYTCIASNAAATVSRERQLIVR-VPPRFVVQPNNQDGIYGKAGVLNCSVDGYP 777

Query: 430  RPAITWQKGERILASGSVQLPRFTPLE-------SGSLLISPTHISDAGTYTCLATNSRG 482
             P + W+  +    SG+ Q     PL        + SLLI      D G Y C A+N  G
Sbjct: 778  PPKVMWKHAK---GSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG 834

Query: 483  VD-EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTE 541
             D   S  L V     IT  P     IKG    + C    +  + IR  WEK    +  +
Sbjct: 835  TDISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIR--WEKGDTVIDPD 892

Query: 542  SHPR--IRLDRNG-----SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPE 594
               R  I    NG     +L +     GD   ++C  I++ G D     L V++ P  PE
Sbjct: 893  RVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPE 952

Query: 595  HPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLAS--VDPKATSVTV 652
                 +  V+ R++NL WT+ FDGNS +  + +E    +  W    ++  + P      +
Sbjct: 953  ---LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANI 1009

Query: 653  KGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQ 712
              L PA  Y  R+ + N +G+ + SK+   +S  E  P  PP +V     T+QSI + W+
Sbjct: 1010 VDLHPASVYSIRMYSFNKIGRSEPSKELT-ISTEEAAPDGPPMDVTLQPVTSQSIQVTWK 1068

Query: 713  PPPESHQNGILKGYIIRYCLAGLPVGYQFKNI---TDADVNNLLLEDLIIWTNYEIEVAA 769
             P +  QNG+++GY I Y         Q+  +      D     L++L  +  Y + V A
Sbjct: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128

Query: 770  YNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKL 829
            +N AG G  SS++   TL+ VP+ PP NV A +  S     +W+ P    +NG+ +GY++
Sbjct: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRV 1188

Query: 830  IAW----EPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP 885
            I W    + E  E   + T R   +       + G++KFT Y   VL +T  GDG RS+ 
Sbjct: 1189 IFWSLYVDGEWGEMQNITTTRERVE-------LRGMEKFTNYSVQVLAYTQAGDGVRSSV 1241

Query: 886  QLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHY 945
              ++T EDVPGP   +       +S+ VSW  P + NG++  Y I            + Y
Sbjct: 1242 LYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEY 1301

Query: 946  LPN-VTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNI 1004
              +   L YR+  L     Y + VAA+TS G+G  S+  ++     + P    + G +  
Sbjct: 1302 ETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGN-SSEKVTIEPAGKAPAKIISFGGTVT 1360

Query: 1005 GP--RSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN 1062
             P  + V L      D   ++ +W  +++   +    +   +   +     R+++  D  
Sbjct: 1361 TPWMKDVRLPCNSVGDPAPAV-KWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419

Query: 1063 PFTCYS-----FRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRW 1117
             +TC +     F    VN++   PP QP                 +++   S +S+ L W
Sbjct: 1420 YYTCTATNTGGFDTIIVNLLVQVPPDQP----------------RLTVSKTSASSITLTW 1463

Query: 1118 MPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQA 1177
            +P      NG     G+ ++YS    + +    V     ER + ++ L+  T Y+V++ A
Sbjct: 1464 IP----GDNGGSSIRGFVLQYSVD--NSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAA 1517

Query: 1178 FNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237
             N++GSG  S+ +  +T    PS   +    L T  +S   R +     +    +    +
Sbjct: 1518 KNSVGSGRISEIIEAKTHGREPSF--SKDQHLFTHINSTHARLNLQGWNNGGCPITAIVL 1575

Query: 1238 MYKEKDSDTQPRFWLVEG---NSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS 1286
             Y+ K +      W  +G   NSS    LT L +   YE+++ A    G G+
Sbjct: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRACNSAGCGN 1621



 Score =  218 bits (555), Expect = 5e-56
 Identities = 356/1569 (22%), Positives = 598/1569 (38%), Gaps = 169/1569 (10%)

Query: 1    MWGLLIWTLLALHQIRAARAQD-DVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFK 59
            MW  L+  LL L  +  AR +D   S YF  + ++         +V+ C A GS     +
Sbjct: 61   MW--LVTFLLLLDSLHKARPEDVGTSLYFVNDSLQQVTFSSSVGVVVPCPAAGSPSAALR 118

Query: 60   W----------------LHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQR 103
            W                +H N  L  +        + +   H   Y C   N  G +   
Sbjct: 119  WYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFI---HDNDYFCTAENAAGKIRSP 175

Query: 104  QTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQ--PQVTWFRDGRKIPPSSRIA 161
               V+  +   +    + Q    G  AV +    +S  +    V+W +D   I P  R  
Sbjct: 176  NIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVSWEKDTVSIIPEHRFF 235

Query: 162  ITLENTLVILSTVAPDAGRYYVQAVNDK-NGDNKTSQPITLTVENVGGPADPIAPTIIIP 220
            IT    L I      DA   Y      K +G+ + S    L+V +   PA+ I PTI+  
Sbjct: 236  ITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD---PAESI-PTILDG 291

Query: 221  PKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNR--RLTIPNPTGSD 278
              +  V AG + V L C A+  P+  +   W KDG  L        R   LTI +    D
Sbjct: 292  FHSQEVWAGHT-VELPCTASGYPIPAIR--WLKDGRPLPADSRWTKRITGLTISDLRTED 348

Query: 279  AGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP 338
            +G Y CE    +++  S      L V++P      P++  T     V+ + C   G P  
Sbjct: 349  SGTYICEV---TNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI-LSCALTGSPEF 404

Query: 339  SITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT 398
            +I WY++  +V  ++    R  ++  L I+      +G +QCFA   A   Q    +A+ 
Sbjct: 405  TIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALE 464

Query: 399  SIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLES 457
               P I     +  V  G    L C   GAP P +TW    E I+  GS +  ++T +  
Sbjct: 465  DGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYT-MSD 523

Query: 458  GSLL----ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQA 513
            G+ +    ++   I D G Y C A N  G  E  A + V     I +  ++ + + G   
Sbjct: 524  GTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVRGPPSI-RAMRNITAVAGRDT 582

Query: 514  SMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSG-DIGTYTCRV- 571
             + C V   P  +I+  W KD A L  ++H ++  + NG+L ++    G D G Y C V 
Sbjct: 583  LINCRVIGYPYYSIK--WYKD-ALLLPDNHRQVVFE-NGTLKLTDVQKGMDEGEYLCSVL 638

Query: 572  ISAGGNDSRSAHLRVRQLP--HAPEHPVATLSTV---------ERRAINLTWTKPFDGNS 620
            I    + S+S H+ V+  P     E P A++  +             I +TW K  DG  
Sbjct: 639  IQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRK--DG-- 694

Query: 621  PLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT 680
               + I+  S         ++S+   + S+   G        +   A N       +   
Sbjct: 695  ---QVIISGSGVTIESKEFMSSLQISSVSLKHNG-------NYTCIASNAAA----TVSR 740

Query: 681  ERVSLPEEPP--TAPPQNVIA----SGRTNQSIMIQWQPPPE---SHQNGILKGYIIRYC 731
            ER  +   PP     P N       +G  N S  +   PPP+    H  G   G   +Y 
Sbjct: 741  ERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCS--VDGYPPPKVMWKHAKG--SGNPQQYH 796

Query: 732  LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVP 791
               L    Q    +   + ++L ED+  +        A N  G  +  S      +  + 
Sbjct: 797  PVPLTGRIQILPNSSLLIRHVLEEDIGYYL-----CQASNGVGTDISKSMFLTVKIPAMI 851

Query: 792  TVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQD 851
            T  P    A   ++  +  T     P  I    +G  +I  +P++     + T + N  +
Sbjct: 852  TSHPNTTIAIKGHAKELNCTARGERPIIIRW-EKGDTVI--DPDRVMRYAIAT-KDNGDE 907

Query: 852  SIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSL 911
             +    +    +    F S     + G+        V+   D P     L   E+   S+
Sbjct: 908  VVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPP----ELEIREVKARSM 963

Query: 912  KVSWQEPGEKNGILTGYRISWEEYNRTNT----RVTHYLPNVTLEYRVTGLTALTTYTIE 967
             + W +  + N I+TG+ I ++  N++++    + T  +     +  +  L   + Y+I 
Sbjct: 964  NLRWTQRFDGNSIITGFDIEYK--NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIR 1021

Query: 968  VAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISR- 1025
            + +    G+ + S     S       GPP ++ +  +  +S+ + ++ P  + +  + R 
Sbjct: 1022 MYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVIRG 1081

Query: 1026 WLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP 1085
            + +  +    G   ++ ++ ++    D+    + +L  F  Y   ++  N  GT  PS  
Sbjct: 1082 YQIGYRENSPGSNGQYSIV-EMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSS 1139

Query: 1086 SRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY--SRSDG 1143
                 TL+  P   P NV   + +     + W   P    NG  +  GY++ +     DG
Sbjct: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLK--GYRVIFWSLYVDG 1197

Query: 1144 HGKTLSHV--VQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSS 1201
                + ++   ++RVE    +  +E++T Y VQV A+   G G  S  +  +T+E VP  
Sbjct: 1198 EWGEMQNITTTRERVE----LRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGP 1253

Query: 1202 GPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA 1261
             P  + A+ +++SS++V W  +P    NG++  Y +      S                 
Sbjct: 1254 -PAGIKAVPSSASSVVVSW--LPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFY 1310

Query: 1262 QLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT----SV 1317
            ++  L +   Y + V A T  G G+ S    +E        P   I F    TT     V
Sbjct: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPA---GKAPAKIISFGGTVTTPWMKDV 1367

Query: 1318 RL----IWQPPAA-------PNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLK 1366
            RL    +  P  A        +  I      HRL  T        V A  +  YT     
Sbjct: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTC---- 1423

Query: 1367 PESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS 1426
                     TA    G+      L+V         PP +P +      A S+ L+W PG 
Sbjct: 1424 ---------TATNTGGFDTIIVNLLVQV-------PPDQPRLTVSKTSASSITLTWIPGD 1467

Query: 1427 DGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSE 1486
            +G S +R + +Q     S  W      +S +  SF +D LK  T YK ++ A N +G   
Sbjct: 1468 NGGSSIRGFVLQYSVDNSEEW--KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGR 1525

Query: 1487 FSEESESLT 1495
             SE  E+ T
Sbjct: 1526 ISEIIEAKT 1534



 Score =  184 bits (468), Expect = 6e-46
 Identities = 186/739 (25%), Positives = 315/739 (42%), Gaps = 87/739 (11%)

Query: 993  PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN-EP 1051
            P  P  L I  +  RS+ L++   +DG + I+ + +E +     + + W       N  P
Sbjct: 947  PPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYK----NKSDSWDFKQSTRNISP 1002

Query: 1052 DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111
                  + DL+P + YS RM   N +G S PS+    I T +A PD  P +V+L+  +  
Sbjct: 1003 TINQANIVDLHPASVYSIRMYSFNKIGRSEPSK-ELTISTEEAAPDGPPMDVTLQPVTSQ 1061

Query: 1112 SLWLRWM-PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD---YTIEDLEE 1167
            S+ + W  P  E++   N    GY+I Y  +         +V+ +   D   YT+++L++
Sbjct: 1062 SIQVTWKAPKKELQ---NGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118

Query: 1168 WTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEAD 1227
            + +Y V VQAFN  G+GP S  +   T E VPS  P NV AL+ TS   ++ WSE P + 
Sbjct: 1119 FAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRST 1178

Query: 1228 RNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 1287
             NG++ GY+V++     D +         +    +L G+ K+  Y VQVLA+T+ GDG  
Sbjct: 1179 LNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVR 1238

Query: 1288 SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANT 1347
            S    ++ T +DVPGPP GI       +SV + W PP  PNG+I  Y I      +    
Sbjct: 1239 SSVLYIQ-TKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPA 1297

Query: 1348 ATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQ------ 1401
             +    +P    Y    L     YL  + A T  G G ++E + +    +   +      
Sbjct: 1298 PSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGG 1357

Query: 1402 PPSRPMVQQEDVRARSV-----LLSWEPGS-DGLSPVRYYTIQTRELPSGRWALHSASVS 1455
              + P ++   +   SV      + W   S D   PV               ++    + 
Sbjct: 1358 TVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPV---------------SMDGHRLI 1402

Query: 1456 HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTT 1515
            H   + ++  +K   S  +   ATN  G      ++  +  L   P + P  L+V+  + 
Sbjct: 1403 HTNGTLLLRAVKAEDSGYYTCTATNTGG-----FDTIIVNLLVQVPPDQPR-LTVSKTSA 1456

Query: 1516 TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
            +S+ + W P      NG                +RGF L+   +    W ++    S R+
Sbjct: 1457 SSITLTWIPGD----NG-------------GSSIRGFVLQYSVDNSEEWKDVFISSSERS 1499

Query: 1576 LSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPT-AAPRNVVVH- 1633
                    ++LD+L     Y+++++  N+VG G  S   E       P+ +  +++  H 
Sbjct: 1500 --------FKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKTHGREPSFSKDQHLFTHI 1551

Query: 1634 GATATQLDVT-WEPP--PLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNL 1690
             +T  +L++  W     P+ +   + +    + W+  R N          +   V L  L
Sbjct: 1552 NSTHARLNLQGWNNGGCPITAIVLEYRPKGTWAWQGLRAN----------SSGEVFLTEL 1601

Query: 1691 TGYTAYMVSVAAFNAAGDG 1709
               T Y + + A N+AG G
Sbjct: 1602 REATWYELRMRACNSAGCG 1620



 Score =  177 bits (449), Expect = 1e-43
 Identities = 126/461 (27%), Positives = 207/461 (44%), Gaps = 41/461 (8%)

Query: 1401 QPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSAS--VSHNA 1458
            +PP  P ++  +V+ARS+ L W    DG S +  + I+ +   S  W    ++  +S   
Sbjct: 946  EPPDPPELEIREVKARSMNLRWTQRFDGNSIITGFDIEYKN-KSDSWDFKQSTRNISPTI 1004

Query: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSV 1518
            +   +  L P + Y  R+ + N IG SE S+E  +++T +AAPD  P  +++ P T+ S+
Sbjct: 1005 NQANIVDLHPASVYSIRMYSFNKIGRSEPSKEL-TISTEEAAPDGPPMDVTLQPVTSQSI 1063

Query: 1519 LIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSR 1578
             + W+ P ++  NG++ G++I YRE              N+PG+        YS+  +  
Sbjct: 1064 QVTWKAPKKELQNGVIRGYQIGYRE--------------NSPGSN-----GQYSIVEMKA 1104

Query: 1579 PSLTQ-YELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATA 1637
               ++ Y LDNL K  +Y + +  +N  G GPSS        E VP+  P NV     T+
Sbjct: 1105 TGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITS 1164

Query: 1638 TQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYM 1697
                ++W  PP  + NG ++GY++ FW          ++ +      V+L+ +  +T Y 
Sbjct: 1165 DVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS 1224

Query: 1698 VSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGY 1757
            V V A+  AGDG RS+    QT++  P  P+ +K    + +SV VSW  P  PNG++  Y
Sbjct: 1225 VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKY 1284

Query: 1758 RLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVT 1817
             +    CS         +        L+ ++  L  G  Y   + A T          VT
Sbjct: 1285 TIF---CSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVT 1341

Query: 1818 TGPGEGAPGPPGVPIIVRYSSAIAIHW---------SSGDP 1849
              P   AP       I+ +   +   W         S GDP
Sbjct: 1342 IEPAGKAPAK-----IISFGGTVTTPWMKDVRLPCNSVGDP 1377



 Score =  133 bits (335), Expect = 2e-30
 Identities = 148/631 (23%), Positives = 259/631 (41%), Gaps = 58/631 (9%)

Query: 1292 ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTAN-TATV 1350
            +++ T+ + P PP  +   EV+  S+ L W      N II  + I ++  + + +   + 
Sbjct: 939  LIQLTVQEPPDPPE-LEIREVKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQST 997

Query: 1351 EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ 1410
              ++P+  Q     L P SVY  R+ +  + G  E ++ L ++TE+     PP    V  
Sbjct: 998  RNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMD--VTL 1055

Query: 1411 EDVRARSVLLSWEPGSDGL--SPVRYYTIQTREL---PSGRWALHSASVSHNASSFIVDR 1465
            + V ++S+ ++W+     L    +R Y I  RE     +G++++     + ++  + +D 
Sbjct: 1056 QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDN 1115

Query: 1466 LKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPP 1525
            LK F  Y   V+A N  G    S E  + TTL+  P + P  +     T+   +I W  P
Sbjct: 1116 LKKFAQYGVVVQAFNRAGTGPSSSEINA-TTLEDVPSQPPENVRALSITSDVAVISWSEP 1174

Query: 1526 AEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYE 1585
                +NG+L G+R+ +  L  +G               W E+ ++ + R        + E
Sbjct: 1175 PRSTLNGVLKGYRVIFWSLYVDG--------------EWGEMQNITTTRE-------RVE 1213

Query: 1586 LDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWE 1645
            L  + K   Y +++  Y   G+G  S    +   E VP   P  +    ++A+ + V+W 
Sbjct: 1214 LRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVP-GPPAGIKAVPSSASSVVVSWL 1272

Query: 1646 PPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNA 1705
            PP     NG I+ Y I+      G            +   ++ +L     Y++ VAA  +
Sbjct: 1273 PP--TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTS 1330

Query: 1706 AGDGPRSTPTQGQTQQAAPSAPSS-VKFSELTTT----SVNVSWEAPQFPNGILEGYRLV 1760
            AG   R   ++  T + A  AP+  + F    TT     V +   +   P   ++  +  
Sbjct: 1331 AG---RGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDS 1387

Query: 1761 YEPCSPV--DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTT 1818
             +   PV  DG   I T     N  L L+    AE   Y       T  +   I   +  
Sbjct: 1388 EDSAIPVSMDGHRLIHT-----NGTLLLRAVK-AEDSGYYTCTATNTGGFDTIIVNLLVQ 1441

Query: 1819 GPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPK 1878
             P    P  P + +    +S+I + W  GD G   I  +V++    +   W    KD+  
Sbjct: 1442 VP----PDQPRLTVSKTSASSITLTWIPGDNGGSSIRGFVLQYSVDNSEEW----KDVFI 1493

Query: 1879 EVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909
              S  +F +D LK G  Y  ++ A N  G G
Sbjct: 1494 SSSERSFKLDSLKCGTWYKVKLAAKNSVGSG 1524



 Score =  122 bits (307), Expect = 3e-27
 Identities = 135/523 (25%), Positives = 213/523 (40%), Gaps = 65/523 (12%)

Query: 1416 RSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFT---SY 1472
            R +++ WE G   + P R            R+A+ +        S +  +LKP     S 
Sbjct: 876  RPIIIRWEKGDTVIDPDRVM----------RYAIATKDNGDEVVSTL--KLKPADRGDSV 923

Query: 1473 KFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKING 1532
             F   A N  G+    +      T+Q  PD  P  L +      S+ +RW    +   N 
Sbjct: 924  FFSCHAINSYGE----DRGLIQLTVQEPPD--PPELEIREVKARSMNLRWTQRFDG--NS 975

Query: 1533 ILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKH 1592
            I+ GF I Y+                N   +W       S RN+S P++ Q  + +L+  
Sbjct: 976  IITGFDIEYK----------------NKSDSW---DFKQSTRNIS-PTINQANIVDLHPA 1015

Query: 1593 RRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQ 1652
              Y IRM  +N +G    S    +   EA P   P +V +   T+  + VTW+ P  + Q
Sbjct: 1016 SVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQ 1075

Query: 1653 NGDIQGYKIYFWEAQRGNLTER--VKTLFLAENSV-KLKNLTGYTAYMVSVAAFNAAGDG 1709
            NG I+GY+I + E   G+  +   V+     ++ V  L NL  +  Y V V AFN AG G
Sbjct: 1076 NGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG 1135

Query: 1710 PRSTPTQGQTQQAAPSAP-SSVKFSELTTTSVNVSWEAPQFP--NGILEGYRLVYEPCSP 1766
            P S+     T +  PS P  +V+   +T+    +SW  P     NG+L+GYR+++     
Sbjct: 1136 PSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLY- 1194

Query: 1767 VDG----VSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVT-TGPG 1821
            VDG    +  I T   +      ++++ + +   Y  ++ A T   G  + ++V      
Sbjct: 1195 VDGEWGEMQNITTTRER------VELRGMEKFTNYSVQVLAYTQA-GDGVRSSVLYIQTK 1247

Query: 1822 EGAPGPP-GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEV 1880
            E  PGPP G+  +   +S++ + W       G I +Y I    S  G       +     
Sbjct: 1248 EDVPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFC--SSPGSGQPAPSEYETSP 1305

Query: 1881 SSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKA 1923
                + +  L  G  Y   V AV   G G  S      PA KA
Sbjct: 1306 EQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score =  311 bits (796), Expect = 6e-84
 Identities = 272/1020 (26%), Positives = 452/1020 (44%), Gaps = 80/1020 (7%)

Query: 5   LIWTLLALHQIRAARAQDDV--SPYFKTEP--VRTQVHLEGNRLVLTCMAEGSWPLEFKW 60
           L+W L+ L  +  + A D +   P F  EP  V   + L  + ++L C A G     ++W
Sbjct: 3   LLWKLVILLPLINSSAGDGLLSRPIFTQEPHDVIFPLDLSKSEVILNCAANGYPSPHYRW 62

Query: 61  LHNNRELTKFSLEYRYMIT----SLDRTHA----GFYRCIVRNRMGALLQRQTEVQVAYM 112
             N  ++  F++ Y Y +     +++  H     G Y+C+  N +G +L R+ ++Q AY+
Sbjct: 63  KQNGTDID-FTMSYHYRLDGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYI 121

Query: 113 GSFEEGEKHQ-SVSHGEAAVIRAPRIASFPQPQVTW-FRDGRK-IPPSSRIAITLENTLV 169
             FE   +   SV  G+  V+       F      W F D    +   +R  ++ E   +
Sbjct: 122 EDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNL 181

Query: 170 ILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAG 229
            ++ V P     Y   + +K        P T  V+   G      P I +    T   A 
Sbjct: 182 YIAKVEPSDVGNYTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAK 241

Query: 230 TSEVTLECVANARPLIKLHIIWKK-DGVLLSGGI--SDHNRRLTIPNPTGSDAGYYECEA 286
            S V LEC A   P+    I W++ DG  L G +  S     L IPN    D G+YEC A
Sbjct: 242 DSSVKLECFALGNPVPD--ISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIA 299

Query: 287 V-LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKD 345
             LR  ++    +G  +    P    K    H++     + +  C+A G P P  TW K+
Sbjct: 300 SNLRGRNL---AKGQLIFYAPPEWEQKIQNTHLSIYDNLLWE--CKASGKPNPWYTWLKN 354

Query: 346 AAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT 405
              +  E+     Q  +G L I+ L   D+G++QC A N    +  +  L V + AP+ +
Sbjct: 355 GERLNPEERI---QIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFS 411

Query: 406 RGPLD--STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLIS 463
           + P+   S V  G  +V+ C+ +  PR AI+W++G   L     Q  R   LE GSL I 
Sbjct: 412 KSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLR----QSKRIFLLEDGSLKIY 467

Query: 464 PTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDP 523
               SDAG+YTC+ATN  G  + +  L+V  RT IT PP    V  G    + C V+HDP
Sbjct: 468 NITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDP 527

Query: 524 RVTIRYIWEKDGATL----GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDS 579
            + + ++W  +G  +    G     RI  +  G L I        G Y C V +   + S
Sbjct: 528 SIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLS 587

Query: 580 RSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVL 639
             A + VR  P  PE     +  +      L+W    D NSP+  + +   +   P++V 
Sbjct: 588 AVADIIVRGPPGPPED--VQVEDISSTTSQLSWRAGPDNNSPIQIFTI---QTRTPFSVG 642

Query: 640 LASV-------DPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTA 692
             +V       + K  + TV GL P   Y+FR+ A N +G G+ S+ +E +      P  
Sbjct: 643 WQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVV 702

Query: 693 PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVG---YQFKNITDADV 749
            P N+   G +   ++I W+  PE  QNG   GYII +     PVG   +  + ++  + 
Sbjct: 703 APVNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMF----RPVGSTTWSKEKVSSVES 758

Query: 750 NNLLL--EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTT 807
           +  +   E +I  + +E++V  YN+ G G  S+    ++ +  P + P     ++ +++ 
Sbjct: 759 SRFVYRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASE 818

Query: 808 IRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEY 867
           +  +WNA +     G   GY+++ W  + +E    +  +     ++    ++GLK  T Y
Sbjct: 819 MEVSWNAIAWNRNTGRVLGYEVLYWTDDSKES---MIGKIRVSGNVTTKNITGLKANTIY 875

Query: 868 FTSVLCFTTPGDGPRSTPQLVRTHEDVPG-PVGHLSFSEILDTSLKVSWQ--EPGEKNGI 924
           F SV  + T G GP S P  V T +  P  P  ++++ ++ ++ L ++W+  +  E    
Sbjct: 876 FASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAW-KLTNSKLCLNWEHVKTMENESE 934

Query: 925 LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALT----TYTIEVAAMTSKGQGQVS 980
           + GY+I + +  ++ T +        LE   T    L      Y IE+  ++  G G  S
Sbjct: 935 VLGYKILYRQNRQSKTHI--------LETNNTSAELLVPFEEDYLIEIRTVSDGGDGSSS 986



 Score =  146 bits (369), Expect = 2e-34
 Identities = 110/376 (29%), Positives = 182/376 (48%), Gaps = 39/376 (10%)

Query: 1397 RDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRW-ALHSASVS 1455
            R  P PP    VQ ED+ + +  LSW  G D  SP++ +TIQTR   S  W A+ +    
Sbjct: 595  RGPPGPPED--VQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEI 652

Query: 1456 HNASSF--IVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPH 1513
             N  ++   V  L P+  Y+FRV A N IG  E SE SE L T  + P  AP  +     
Sbjct: 653  LNGKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGG 712

Query: 1514 TTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAE--LTSMY 1571
            + + ++I W+   E+  NG   G+ I +R +                  TW++  ++S+ 
Sbjct: 713  SRSELVITWESIPEELQNGEGFGYIIMFRPV---------------GSTTWSKEKVSSVE 757

Query: 1572 SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVV 1631
            S R +       Y  +++     +E+++ VYN  GEG  S    V+ GE  P  APR   
Sbjct: 758  SSRFV-------YRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTS 810

Query: 1632 VHGATATQLDVTWEPPPLDSQNGDIQGYKIYFW-EAQRGNLTERVKTLFLAENSVKLKNL 1690
            +   +A++++V+W     +   G + GY++ +W +  + ++  +++       +V  KN+
Sbjct: 811  LQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIR----VSGNVTTKNI 866

Query: 1691 TGY---TAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAP 1747
            TG    T Y  SV A+N AG GP S P    T+++ PS P +    +LT + + ++WE  
Sbjct: 867  TGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHV 926

Query: 1748 QFPNGILE--GYRLVY 1761
            +      E  GY+++Y
Sbjct: 927  KTMENESEVLGYKILY 942



 Score =  115 bits (287), Expect = 6e-25
 Identities = 96/392 (24%), Positives = 165/392 (42%), Gaps = 17/392 (4%)

Query: 980  SASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGE 1039
            S S ++  +    PGPP ++ + +I   +  L +R G D  + I  + ++ +       +
Sbjct: 585  SLSAVADIIVRGPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQ 644

Query: 1040 EWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA 1099
                + ++ N     +  V  L+P+  Y FR+   N +G   PS+PS  ++T  + P +A
Sbjct: 645  AVATVPEILNGKTYNATVV-GLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVA 703

Query: 1100 PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY---SRSDGHGKTLSHVVQDRV 1156
            P N+     S + L + W  +PE   NG  E  GY I +     +    + +S V   R 
Sbjct: 704  PVNIHGGGGSRSELVITWESIPEELQNG--EGFGYIIMFRPVGSTTWSKEKVSSVESSRF 761

Query: 1157 ERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSM 1216
               Y  E +   + + V+V  +N  G G  S   +  + E  P   P   S  + ++S M
Sbjct: 762  V--YRNESIIPLSPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEM 819

Query: 1217 LVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQV 1276
             V W+ +      G VLGY+V+Y   DS       +    +  +  +TGL    +Y   V
Sbjct: 820  EVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASV 879

Query: 1277 LAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQ--PPAAPNGIILAY 1334
             A+   G G PS PP+   T    P  P   +  ++  + + L W+          +L Y
Sbjct: 880  RAYNTAGTG-PSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLNWEHVKTMENESEVLGY 938

Query: 1335 QITHRLNTTT------ANTATVEVLAPSARQY 1360
            +I +R N  +       N  + E+L P    Y
Sbjct: 939  KILYRQNRQSKTHILETNNTSAELLVPFEEDY 970



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 95/406 (23%), Positives = 172/406 (42%), Gaps = 25/406 (6%)

Query: 1096 PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDR 1155
            P   P +V +   S T+  L W   P+        ++  +  +S       T+  ++  +
Sbjct: 597  PPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGK 656

Query: 1156 VERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGPTNVSALATTSS 1214
               + T+  L  W EY  +V A N+IG G P   + + RT+ SVP   P N+     + S
Sbjct: 657  TY-NATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRS 715

Query: 1215 SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSS-RSAQLTGLGKYVL-- 1271
             +++ W  +PE  +NG   GY +M++   S T    W  E  SS  S++     + ++  
Sbjct: 716  ELVITWESIPEELQNGEGFGYIIMFRPVGSTT----WSKEKVSSVESSRFVYRNESIIPL 771

Query: 1272 --YEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPA--AP 1327
              +EV+V  +   G+GS S   I+    D+    P G        + + + W   A    
Sbjct: 772  SPFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRN 831

Query: 1328 NGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAA 1387
             G +L Y++ +  + +  +      ++ +      TGLK  ++Y   + A    G G ++
Sbjct: 832  TGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSS 891

Query: 1388 EALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE--PGSDGLSPVRYYTIQTRELPSG 1445
              + VTT+K    QPP+    +  + +   + L+WE     +  S V  Y I  R+    
Sbjct: 892  PPVNVTTKKSPPSQPPANIAWKLTNSK---LCLNWEHVKTMENESEVLGYKILYRQNRQS 948

Query: 1446 RWALHSASVSHNASSFIVDRLKPF-TSYKFRVKATNDIGDSEFSEE 1490
            +   H    ++ ++  +V    PF   Y   ++  +D GD   SEE
Sbjct: 949  K--THILETNNTSAELLV----PFEEDYLIEIRTVSDGGDGSSSEE 988



 Score = 61.6 bits (148), Expect = 8e-09
 Identities = 70/293 (23%), Positives = 123/293 (41%), Gaps = 16/293 (5%)

Query: 1260 SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPG-PPMGILFPEVRTTSVR 1318
            +A + GL  +V YE +V+A   IG G PS P  L RT   VP   P+ I       + + 
Sbjct: 659  NATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELV 718

Query: 1319 LIWQ--PPAAPNGIILAYQITHR-LNTTTANTATVEVLAPSARQYTATGLKPESVYLFRI 1375
            + W+  P    NG    Y I  R + +TT +   V  +  S   Y    + P S +  ++
Sbjct: 719  ITWESIPEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIPLSPFEVKV 778

Query: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSV---LLSWEPGSDGLS-- 1430
                 +G G  +   +V + + +    P    +Q        V    ++W   +  +   
Sbjct: 779  GVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQSFSASEMEVSWNAIAWNRNTGRVLGY 838

Query: 1431 PVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEE 1490
             V Y+T  ++E   G+       VS N ++  +  LK  T Y   V+A N  G    S  
Sbjct: 839  EVLYWTDDSKESMIGK-----IRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGP-SSP 892

Query: 1491 SESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRE 1543
              ++TT ++ P + P  ++    T + + + W+     +    +LG++I YR+
Sbjct: 893  PVNVTTKKSPPSQPPANIA-WKLTNSKLCLNWEHVKTMENESEVLGYKILYRQ 944



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 32/106 (30%), Positives = 52/106 (49%), Gaps = 7/106 (6%)

Query: 1826 GPPGVPIIVRY----SSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
            GPPG P  V+     S+   + W +G     PI  + I+ R      W   +  +P+ ++
Sbjct: 596  GPPGPPEDVQVEDISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQA-VATVPEILN 654

Query: 1882 SYTFSMDI--LKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
              T++  +  L P V Y+FRV+A N  G G PS PS+ +  + + P
Sbjct: 655  GKTYNATVVGLSPWVEYEFRVVAGNSIGIGEPSEPSELLRTKASVP 700


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  310 bits (794), Expect = 1e-83
 Identities = 274/1010 (27%), Positives = 436/1010 (43%), Gaps = 62/1010 (6%)

Query: 5   LIWTLLALHQIRAARAQDDV--SPYFKTEP--VRTQVHLEGNRLVLTCMAEGSWPLEFKW 60
           L W LL L       A D     P F  EP  V   +  E  ++ L C  +G+     +W
Sbjct: 3   LPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRW 62

Query: 61  LHNNRELTKFSLEYRY-------MITSLDRTH-AGFYRCIVRNRMGALLQRQTEVQVAYM 112
             N  ++    +++RY       +I + ++T  AG Y+C   N  G ++ R+ ++Q AY+
Sbjct: 63  KLNGTDVDT-GMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYL 121

Query: 113 GSFEEGEKHQ-SVSHGEAAVIRAPRIASFPQPQVTW-FRDGRKIPPSSRIAITLENTLVI 170
            +F+   +   SV  G+  V+         +    W F +      + R        L I
Sbjct: 122 DNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181

Query: 171 LSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGT 230
                 D G Y     N          P  L + N G   +   P I +    T   A  
Sbjct: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGE-YEPKIEVQFPETVPTAKG 240

Query: 231 SEVTLECVANARPLIKLHIIWKK-DGVLLSGGISDH--NRRLTIPNPTGSDAGYYECEAV 287
           + V LEC A   P+    IIW++ DG  ++     H  N  L IPN    DAG YEC  V
Sbjct: 241 ATVKLECFALGNPVPT--IIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYEC--V 296

Query: 288 LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
             +S   +V RG      +P    K  + H+   ME+ V   C+A G P P+  W K+  
Sbjct: 297 AENSRGKNVARGQLTFYAQPNWIQKINDIHVA--MEENVFWECKANGRPKPTYKWLKNGE 354

Query: 348 VVEVEKLTRFR-QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITR 406
            +    LTR R Q   G L I+ +   D GM+QC A N  G + ++  L+V ++ P+ +R
Sbjct: 355 PL----LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSR 410

Query: 407 GPLDSTVID--GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISP 464
             L    +   G  VV+ C+   +P+P  TW+KG  IL        R T  E G+L I  
Sbjct: 411 TLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENE----RITISEDGNLRIIN 466

Query: 465 THISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 524
              SDAG+YTC+ATN  G   ++ +LVV   TR+  PP    V  G    + C VTHD  
Sbjct: 467 VTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHS 526

Query: 525 VTIRYIWEKDGATL-----GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDS 579
           + I + W  +G  +     G         D  G L I        G Y C V ++    S
Sbjct: 527 LDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLS 586

Query: 580 RSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE-MSENNAPW-- 636
            +A L VR  P  PE    T+  +      L+W    D +SP+  Y+++  +  +  W  
Sbjct: 587 AAADLIVRGPPGPPE--AVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA 644

Query: 637 -TVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQ 695
            + +   +D K  + TV GL P   Y+FR  A N +G G+ S+ +E+    E  P   P 
Sbjct: 645 VSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPA 704

Query: 696 NVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL- 754
           NV   G +   ++I W+  PE  QNG   GY++ +   G  + +    +  AD +  +  
Sbjct: 705 NVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMI-WMLTVLASADASRYVFR 763

Query: 755 -EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWN 813
            E +  ++ +E++V  +N+ G G +S     ++ +  PT PP ++ A + ++T I   W 
Sbjct: 764 NESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWA 823

Query: 814 APSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLC 873
           +P  +   G  QGY++  W  E +EE          Q S     ++ LK    Y  +V  
Sbjct: 824 SPLEK-NRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTK---ITNLKGSVLYHLAVKA 879

Query: 874 FTTPGDGPRSTPQLVRTHEDVPG-PVGHLSFSEILDTSLKVSWQEPG--EKNGILTGYRI 930
           + + G GP S    V T +  P  P G++ ++   D+ + ++W +    +    + GY++
Sbjct: 880 YNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNS-SDSKIILNWDQVKALDNESEVKGYKV 938

Query: 931 SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVS 980
            +  +NR ++         ++E     L     Y IE+   +  G G  S
Sbjct: 939 LY-RWNRQSSTSVIETNKTSVE---LSLPFDEDYIIEIKPFSDGGDGSSS 984



 Score =  141 bits (356), Expect = 6e-33
 Identities = 106/381 (27%), Positives = 171/381 (44%), Gaps = 32/381 (8%)

Query: 1386 AAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSG 1445
            AA  L+V    R  P PP    +  +++   +  LSW PG D  SP+  Y IQ R   S 
Sbjct: 587  AAADLIV----RGPPGPPEAVTI--DEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSV 640

Query: 1446 RWALHSAS---VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 1502
             W   S     +     +  V  L P+  Y+FR  A N IG  E S  SE   T +A P+
Sbjct: 641  GWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPE 700

Query: 1503 EAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGA 1562
              P  +S    + + ++I W+   E+  NG   G+ + +R     G   + L  + +  A
Sbjct: 701  VTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPY---GKMIWMLTVLASADA 757

Query: 1563 TWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV 1622
                  S Y  RN           ++++    +E+++ V+N  GEGP SP   V+  E  
Sbjct: 758  ------SRYVFRN-----------ESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEE 800

Query: 1623 PTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
            PT  P ++     +AT ++V W   PL+   G IQGY++ +W  +      R       +
Sbjct: 801  PTKPPASIFARSLSATDIEVFW-ASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQ 859

Query: 1683 NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
             S K+ NL G   Y ++V A+N+AG GP S      T++  PS P        + + + +
Sbjct: 860  TSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIIL 919

Query: 1743 SWEAPQFPNGILE--GYRLVY 1761
            +W+  +  +   E  GY+++Y
Sbjct: 920  NWDQVKALDNESEVKGYKVLY 940



 Score =  130 bits (326), Expect = 2e-29
 Identities = 108/384 (28%), Positives = 179/384 (46%), Gaps = 28/384 (7%)

Query: 993  PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGV-VGEGEEWLLIHQLSNEP 1051
            PGPP  + I  I   +  L +RPG D  + I+ ++++A+    VG    W  +  +    
Sbjct: 597  PGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVG----WQAVSTVPELI 652

Query: 1052 DARSME--VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
            D ++    V  LNP+  Y FR    N++G   PS+PS K +T +A P++ PANVS    S
Sbjct: 653  DGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGS 712

Query: 1110 ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVV----QDRVERDYTIEDL 1165
            ++ L + W  +PE   NG     GY + +     +GK +  +      D     +  E +
Sbjct: 713  KSELVITWETVPEELQNG--RGFGYVVAFR---PYGKMIWMLTVLASADASRYVFRNESV 767

Query: 1166 EEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPE 1225
              ++ + V+V  FN  G GP+S T V  + E  P+  P ++ A + +++ + V W+   E
Sbjct: 768  HPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLE 827

Query: 1226 ADRNGLVLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGD 1284
             +R G + GY+V Y + +D +   R     GN + S ++T L   VLY + V A+   G 
Sbjct: 828  KNR-GRIQGYEVKYWRHEDKEENARKIRTVGNQT-STKITNLKGSVLYHLAVKAYNSAGT 885

Query: 1285 GSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIW-QPPAAPN-GIILAYQITHRLNT 1342
            G PS   +   T    P  P G +      + + L W Q  A  N   +  Y++ +R N 
Sbjct: 886  G-PSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNR 944

Query: 1343 TTA------NTATVEVLAPSARQY 1360
             ++      N  +VE+  P    Y
Sbjct: 945  QSSTSVIETNKTSVELSLPFDEDY 968



 Score =  101 bits (252), Expect = 7e-21
 Identities = 98/404 (24%), Positives = 163/404 (40%), Gaps = 22/404 (5%)

Query: 1096 PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDR 1155
            P   P  V++   ++T+  L W P P+   N +P ++ Y I+       G      V + 
Sbjct: 596  PPGPPEAVTIDEITDTTAQLSWRPGPD---NHSPITM-YVIQARTPFSVGWQAVSTVPEL 651

Query: 1156 VERDY---TIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGPTNVSALAT 1211
            ++      T+  L  W EY  +  A N IG G P   +   RT E++P   P NVS    
Sbjct: 652  IDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGG 711

Query: 1212 TSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYV 1270
            + S +++ W  VPE  +NG   GY V ++           L   ++SR   +   +  + 
Sbjct: 712  SKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFS 771

Query: 1271 LYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPN-G 1329
             +EV+V  F   G+G  S   ++    ++   PP  I    +  T + + W  P   N G
Sbjct: 772  PFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRG 831

Query: 1330 IILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEA 1389
             I  Y++ +  +      A       +      T LK   +Y   + A    G G ++  
Sbjct: 832  RIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSAT 891

Query: 1390 LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE--PGSDGLSPVRYYTIQTRELPSGRW 1447
            + VTT K    QPP   +    D +   ++L+W+     D  S V+ Y +        RW
Sbjct: 892  VNVTTRKPPPSQPPGNIIWNSSDSK---IILNWDQVKALDNESEVKGYKVLY------RW 942

Query: 1448 ALHSASVSHNASSFIVDRLKPF-TSYKFRVKATNDIGDSEFSEE 1490
               S++     +   V+   PF   Y   +K  +D GD   SE+
Sbjct: 943  NRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQ 986



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 37/106 (34%), Positives = 51/106 (48%), Gaps = 4/106 (3%)

Query: 1823 GAPGPPGVPIIVRYSSAIA-IHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
            G PGPP    I   +   A + W  G     PIT YVI+AR      W   +  +P+ + 
Sbjct: 595  GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQA-VSTVPELID 653

Query: 1882 SYTFSMDI--LKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
              TF+  +  L P V Y+FR +A N  G G PS PS+    ++A P
Sbjct: 654  GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALP 699



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 90/450 (20%), Positives = 168/450 (37%), Gaps = 39/450 (8%)

Query: 791  PTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQ 850
            P  PP  V  +    TT + +W  P P   + I   Y + A  P       + T      
Sbjct: 596  PPGPPEAVTIDEITDTTAQLSWR-PGPDNHSPITM-YVIQARTPFSVGWQAVSTVPELID 653

Query: 851  DSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP-QLVRTHEDVPGPV-GHLSFSEILD 908
                   V GL  + EY    +     G G  S P +  RT E +P     ++S      
Sbjct: 654  GKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSK 713

Query: 909  TSLKVSWQEPGEK--NGILTGYRISWEEYNRTNTRVTHYLPNVTLEY--RVTGLTALTTY 964
            + L ++W+   E+  NG   GY +++  Y +    +T         Y  R   +   + +
Sbjct: 714  SELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPF 773

Query: 965  TIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSV------TLQFRPGYD 1018
             ++V    +KG+G  S +T+      E   PP ++   ++    +       L+   G  
Sbjct: 774  EVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRI 833

Query: 1019 GKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVG 1078
                +  W  E       + E    I  + N+    S ++ +L     Y   ++  N  G
Sbjct: 834  QGYEVKYWRHE------DKEENARKIRTVGNQ---TSTKITNLKGSVLYHLAVKAYNSAG 884

Query: 1079 TSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY 1138
            T  PS  +  + T + PP   P N+ +  +S++ + L W  +  ++     E  GYK+ Y
Sbjct: 885  TG-PSSATVNVTTRKPPPSQPPGNI-IWNSSDSKIILNWDQVKALD--NESEVKGYKVLY 940

Query: 1139 SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV-------V 1191
              +     ++    +  VE     ++     +Y ++++ F+  G G  S+ +        
Sbjct: 941  RWNRQSSTSVIETNKTSVELSLPFDE-----DYIIEIKPFSDGGDGSSSEQIRIPKISNA 995

Query: 1192 GRTRESVPSSGPTNVSALATTSSSMLVRWS 1221
                    +S    +SA++T   S+  R S
Sbjct: 996  YARGSGASTSNACTLSAISTIMISLTARSS 1025


>gi|4827022 contactin 2 precursor [Homo sapiens]
          Length = 1040

 Score =  282 bits (722), Expect = 2e-75
 Identities = 245/954 (25%), Positives = 408/954 (42%), Gaps = 66/954 (6%)

Query: 17  AARAQDDVSPYFKTEPVRTQVHLEGN--RLVLTCMAEGSWPLEFKWLHNNRELTKFSLEY 74
           A  +Q    P F+ +P+      E    +++L C A  S P  ++W  N  E+ K     
Sbjct: 28  ALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEM-KLEPGS 86

Query: 75  RYMITS--------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSH 126
           R+ +               AG Y+C+  N +G ++ R+  ++  ++  F + E+    +H
Sbjct: 87  RHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAH 146

Query: 127 -GEAAVIRAPRIASFPQPQVTWFRDG--RKIPPSSRIAIT-LENTLVILSTVAPDAGRYY 182
            G   ++     A +P     W  +     IP   R  ++     L I  T A D G Y 
Sbjct: 147 EGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYS 206

Query: 183 VQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIP-PKNTSVVAGTSEVTLECVANA 241
             A +  +   K+       +          AP+I    P  T  + G  +VTLEC A  
Sbjct: 207 CLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVG-QQVTLECFAFG 265

Query: 242 RPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 301
            P+ ++   W+K    LS   +     L IP+ +  D G YECEA   +S     V+G  
Sbjct: 266 NPVPRIK--WRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEA--ENSKGRDTVQGRI 321

Query: 302 LSVLEPP--QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKD----AAVVEVEKLT 355
           +   +P   + + + E  I + +       C A G P P++ W ++    A+   VE L 
Sbjct: 322 IVQAQPEWLKVISDTEADIGSNLRW----GCAAAGKPRPTVRWLRNGEPLASQNRVEVLA 377

Query: 356 RFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTV-- 413
                  G L+ S L  +D+GM+QC A N  G +  S  LAV ++AP+    P+   +  
Sbjct: 378 -------GDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPA 430

Query: 414 IDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTY 473
             G  +++ C+   AP+  + W KG  IL + S    R T    G+L+I     SD G Y
Sbjct: 431 ARGGEILIPCQPRAAPKAVVLWSKGTEILVNSS----RVTVTPDGTLIIRNISRSDEGKY 486

Query: 474 TCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEK 533
           TC A N  G   ++  L V   T+IT  P    +  G   ++ C  +HDP + + + W  
Sbjct: 487 TCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTL 546

Query: 534 DGATLGTES----HPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ 588
           D   +  +     + R  +    G L I        G YTC   +   + S+ A + VR 
Sbjct: 547 DDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRG 606

Query: 589 LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNA-PWTVLL---ASVD 644
            P  P   V  +  +    I L+W++ FD +SP+ +Y L+     A  W  +    A+++
Sbjct: 607 PPGPPGGVV--VRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIE 664

Query: 645 PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTN 704
             A +  V GL P   Y+FR+ A N +G G+ S  + ++   E  P+  P  +   G   
Sbjct: 665 GNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAP 724

Query: 705 QSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL--EDLIIWTN 762
             +++ W P    +QNG   GY++ +   G    +Q   +  AD    +   E +  +T 
Sbjct: 725 GELIVNWTPMSREYQNGDGFGYLLSFRRQG-STHWQTARVPGADAQYFVYSNESVRPYTP 783

Query: 763 YEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFING 822
           +E+++ +YN  G G  S     ++ +  P V P  V A+  +S+ +  TW  P  Q +NG
Sbjct: 784 FEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWE-PVQQDMNG 842

Query: 823 INQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPR 882
           I  GY++  W+   +E             S     VSGL   T+Y  +V  +   G GP 
Sbjct: 843 ILLGYEIRYWKAGDKEAAADRVRTAGLDTSAR---VSGLHPNTKYHVTVRAYNRAGTGPA 899

Query: 883 STPQLVRTHEDVP-GPVGHLSFSEILDTSLKVSWQE--PGEKNGILTGYRISWE 933
           S      T +  P  P G++S++    +SL + W    P      +TGY++ ++
Sbjct: 900 SPSANATTMKPPPRRPPGNISWT-FSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952



 Score =  160 bits (405), Expect = 1e-38
 Identities = 120/417 (28%), Positives = 196/417 (47%), Gaps = 38/417 (9%)

Query: 1360 YTATGLKPESVYLFRITAQTRKGWGEAAEALVV--------TTEKRDRPQPPSRPMVQQE 1411
            Y  T +K     L  + AQ R G      A  V        T   R  P PP   +V+  
Sbjct: 560  YRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVR-- 617

Query: 1412 DVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWA---LHSASVSHNASSFIVDRLKP 1468
            D+   ++ LSW  G D  SP+  YT+Q R  P+G+W     + A++  NA +  V  L P
Sbjct: 618  DIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTP 677

Query: 1469 FTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAED 1528
            +  Y+FRV A+N +G  E S  S  + T +AAP  AP+ LS        +++ W P + +
Sbjct: 678  WMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSRE 737

Query: 1529 KINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDN 1588
              NG   G+ + +R    +G   +    +  PGA      + Y +          Y  ++
Sbjct: 738  YQNGDGFGYLLSFRR---QGSTHWQTARV--PGA-----DAQYFV----------YSNES 777

Query: 1589 LNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPP 1648
            +  +  +E+++  YN  G+GP S    V+  E  P  AP  V   G ++++++VTWEP  
Sbjct: 778  VRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQ 837

Query: 1649 LDSQNGDIQGYKIYFWEA-QRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAG 1707
             D  NG + GY+I +W+A  +    +RV+T  L + S ++  L   T Y V+V A+N AG
Sbjct: 838  QD-MNGILLGYEIRYWKAGDKEAAADRVRTAGL-DTSARVSGLHPNTKYHVTVRAYNRAG 895

Query: 1708 DGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE--APQFPNGILEGYRLVYE 1762
             GP S      T +  P  P        +++S+++ W+   P      + GY+++Y+
Sbjct: 896  TGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQ 952



 Score =  149 bits (376), Expect = 3e-35
 Identities = 130/485 (26%), Positives = 215/485 (44%), Gaps = 46/485 (9%)

Query: 880  GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTN 939
            G   T Q   +H+    P   L+F+  LD    + + +PG               Y RTN
Sbjct: 523  GDNLTLQCHASHD----PTMDLTFTWTLD-DFPIDFDKPGG-------------HYRRTN 564

Query: 940  TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQV-SASTISSGVPPELPGPPTN 998
             + T           +  LT L          T   Q  V SAS  ++ +    PGPP  
Sbjct: 565  VKET-----------IGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGG 613

Query: 999  LGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEV 1058
            + + +IG  ++ L +  G+D  + I+++ ++A+    G+ ++ +  +  + E +A + +V
Sbjct: 614  VVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQ-VRTNPANIEGNAETAQV 672

Query: 1059 PDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWM 1118
              L P+  Y FR+   NI+GT  PS PS KI+T +A P +AP+ +S    +   L + W 
Sbjct: 673  LGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWT 732

Query: 1119 PLPEMEYNGNPESVGYKIKYSRSDG-HGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQA 1177
            P+     NG  +  GY + + R    H +T      D     Y+ E +  +T + V++++
Sbjct: 733  PMSREYQNG--DGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRS 790

Query: 1178 FNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKV 1237
            +N  G GP S T +  + E  P   PT V A   +SS M V W  V + D NG++LGY++
Sbjct: 791  YNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPV-QQDMNGILLGYEI 849

Query: 1238 MYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTL 1297
             Y +          +       SA+++GL     Y V V A+ R G G P+ P     T+
Sbjct: 850  RYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTG-PASPSANATTM 908

Query: 1298 DDVPGPPMGILFPEVRTTSVRLIWQP------PAAPNGIILAYQ----ITHRLNTTTANT 1347
               P  P G +     ++S+ + W P       +A  G  + YQ    +T  L+ T  N 
Sbjct: 909  KPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNW 968

Query: 1348 ATVEV 1352
              + V
Sbjct: 969  IEIPV 973



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 79/305 (25%), Positives = 139/305 (45%), Gaps = 22/305 (7%)

Query: 1253 VEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPG-PPMGILFPE 1311
            +EGN+  +AQ+ GL  ++ YE +V+A   +G G PS P    RT +  P   P G+    
Sbjct: 663  IEGNAE-TAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGG 721

Query: 1312 VRTTSVRLIWQPPAAP--NGIILAYQITHRLNTTTA-NTATVEVLAPSARQYTATGLKPE 1368
                 + + W P +    NG    Y ++ R   +T   TA V         Y+   ++P 
Sbjct: 722  GAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPY 781

Query: 1369 SVYLFRITAQTRKGWG-EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSD 1427
            + +  +I +  R+G G E+  ALV + E+  R  P     V  + V +  + ++WEP   
Sbjct: 782  TPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTK---VWAKGVSSSEMNVTWEPVQQ 838

Query: 1428 GLS------PVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATND 1481
             ++       +RY+    +E  + R  + +A +  +A    V  L P T Y   V+A N 
Sbjct: 839  DMNGILLGYEIRYWKAGDKEAAADR--VRTAGLDTSAR---VSGLHPNTKYHVTVRAYNR 893

Query: 1482 IGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY 1541
             G    S  S + TT++  P   P  +S T  +++S+ I+W P    +    + G+++ Y
Sbjct: 894  AGTGPASP-SANATTMKPPPRRPPGNISWT-FSSSSLSIKWDPVVPFRNESAVTGYKMLY 951

Query: 1542 RELLY 1546
            +  L+
Sbjct: 952  QNDLH 956



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 42/132 (31%), Positives = 62/132 (46%), Gaps = 9/132 (6%)

Query: 1798 RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRY--SSAIAIHWSSGDPGKGPIT 1855
            ++   A+T       EA V      G PGPPG  ++VR    + I + WS G     PI 
Sbjct: 584  KYTCMAQTVVDSASKEATVLV---RGPPGPPG-GVVVRDIGDTTIQLSWSRGFDNHSPIA 639

Query: 1856 RYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDIL--KPGVSYDFRVIAVNDYGFGTPSS 1913
            +Y ++AR    G W   ++  P  +     +  +L   P + Y+FRVIA N  G G PS 
Sbjct: 640  KYTLQARTPPAGKWK-QVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSG 698

Query: 1914 PSQSVPAQKANP 1925
            PS  +  ++A P
Sbjct: 699  PSSKIRTREAAP 710


>gi|28373129 contactin 5 isoform short [Homo sapiens]
          Length = 1026

 Score =  275 bits (703), Expect = 4e-73
 Identities = 263/1007 (26%), Positives = 415/1007 (41%), Gaps = 59/1007 (5%)

Query: 7   WTLLALHQIRAARAQD-DVSPYFKTEP--VRTQVHLEGNRLVLTCMAEGSWPLEFKWLHN 63
           W L+    +    ++  D  P F  EP  +      +  ++ L C   G+    ++WL N
Sbjct: 5   WKLMLFLSVTMCLSESVDYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRN 64

Query: 64  NRELTKFSLEYRYMITS--------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSF 115
             E+   S +YRY +           +   +G Y+C+  N +G++L R+  +Q AY+G+F
Sbjct: 65  GTEIDLES-DYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNF 123

Query: 116 EEGEKHQ-SVSHGEAAVIRAPRIASFPQPQVTW-FRDGRK-IPPSSRIAITLENTLVILS 172
               +   SV  G+  V+        P+   +W F +    +   SR  I+ E   + +S
Sbjct: 124 SGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYIS 183

Query: 173 TV-APDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTS 231
            V   D G Y     N        S P  LT+ N G   +   P I +    T   A  +
Sbjct: 184 KVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGE-YEPKIEVHFPFTVTAAKGT 242

Query: 232 EVTLECVANARPLIKLHIIWKK-DGVLLSGG-ISDHNRRLTIPNPTGSDAGYYECEAVLR 289
            V +EC A   P+    I W K +G + S   +      L IPN    DAG YEC A   
Sbjct: 243 TVKMECFALGNPVPT--ITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA--E 298

Query: 290 SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV 349
           +S   +  RG  L V   P +V E       +    +   C+A G P P+  W K+   V
Sbjct: 299 NSRGKNSFRGQ-LQVYTYPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--V 354

Query: 350 EVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL 409
            +   +R    N G L I  +   D GM+QC A N  G +  S  L + + AP      L
Sbjct: 355 PLSPQSRVEMVN-GVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQL 413

Query: 410 DSTVI--DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHI 467
             T+I      VV+ C+  G+P+P I+W+KG+R +        R   L  GSL I     
Sbjct: 414 KKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILNASK 469

Query: 468 SDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI 527
           SD G Y C   N  G  E  A L V   TRI   P+   +  G    + C   HD  + +
Sbjct: 470 SDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDV 529

Query: 528 RYIWEKDGATLGTESH----PRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSA 582
            + W   G  +  E        IR   + + L I        G Y CRV +   + S  A
Sbjct: 530 TFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEA 589

Query: 583 HLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEM-SENNAPWTVLLA 641
            L VR  P  P   +  +  +      L+W+   D +SP+  Y L+  S  +  W  +  
Sbjct: 590 ELLVRGPPGPPG--IVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKT 647

Query: 642 S---VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVI 698
               +     S     L P   Y+FR+ A N +G G  S  +  +   E  P   P NV 
Sbjct: 648 VPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVS 707

Query: 699 ASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLI 758
                   ++I W+P  E  QNG   GYI+ +   G   G++ K +T ++ +  +  D  
Sbjct: 708 GRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDES 766

Query: 759 I--WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPS 816
           +   T +E++V  YN+ G G +S  V   + +G P+  P +V A + + + I   W    
Sbjct: 767 VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 826

Query: 817 PQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTT 876
                G  QG+++  W+ + E+E T  T +    +S  +  ++GL+  T Y  +V  +  
Sbjct: 827 ESL--GRPQGFEVGYWK-DMEQEDTAETVKTRGNESFVI--LTGLEGNTLYHFTVRAYNG 881

Query: 877 PGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQE--PGEKNGILTGYRISWEE 934
            G GP S+     T +  P         E   + + + W+   P      + GY++ + +
Sbjct: 882 AGYGPPSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQ 941

Query: 935 YNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA 981
              +N++V   +    L+  V  L     Y IEV A +  G G  S+
Sbjct: 942 EGHSNSQV---IETQKLQ-AVVPLPDAGVYIIEVRAYSEGGDGTASS 984



 Score =  142 bits (357), Expect = 5e-33
 Identities = 114/384 (29%), Positives = 185/384 (48%), Gaps = 38/384 (9%)

Query: 1385 EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPS 1444
            + AE LV     R  P PP   +V  E++   +  LSW P +D  SP+  Y +Q R   S
Sbjct: 587  DEAELLV-----RGPPGPPGIVIV--EEITESTATLSWSPAADNHSPISSYNLQARSPFS 639

Query: 1445 GRWALHSAS---VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501
              W         ++ +  S +   L P+  Y+FRV ATN IG  + S  S  + T +A P
Sbjct: 640  LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 699

Query: 1502 DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
              APT +S        ++I W+P +E+  NG   G+ + +R     G RG+  + + +  
Sbjct: 700  KTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRP---NGTRGWKEKMVTSSE 756

Query: 1562 ATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEA 1621
            A      S +  R+ S P LT            +E+++ VYN  G+GP S    +   E 
Sbjct: 757  A------SKFIYRDESVPPLTP-----------FEVKVGVYNNKGDGPFSQIVVICSAEG 799

Query: 1622 VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFW-EAQRGNLTERVKTLFL 1680
             P+AAP +V     + +++ V W+   +    G  QG+++ +W + ++ +  E VKT   
Sbjct: 800  EPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRG- 856

Query: 1681 AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS-APSSVKFSELTTTS 1739
             E+ V L  L G T Y  +V A+N AG GP S+     T+++ PS APS++++ E   + 
Sbjct: 857  NESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQ 915

Query: 1740 VNVSWE--APQFPNGILEGYRLVY 1761
            V++ WE   P      + GY++ Y
Sbjct: 916  VSLGWEPVIPLANESEVVGYKVFY 939



 Score =  139 bits (351), Expect = 2e-32
 Identities = 118/408 (28%), Positives = 180/408 (44%), Gaps = 24/408 (5%)

Query: 993  PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPD 1052
            PGPP  + +  I   + TL + P  D  + IS + ++A+       +    + ++    D
Sbjct: 597  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG-D 655

Query: 1053 ARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETS 1112
              S    DLNP+  Y FR+   N +GT  PS PSR I+T +A P  AP NVS R+     
Sbjct: 656  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHE 715

Query: 1113 LWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER-DYTIEDLEEWTEY 1171
            L + W P+ E   NG  E  GY + +  +   G     V      +  Y  E +   T +
Sbjct: 716  LVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 773

Query: 1172 RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGL 1231
             V+V  +N  G GP+SQ VV  + E  PS+ PT+V A + + S +LV W  + E+   G 
Sbjct: 774  EVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKES--LGR 831

Query: 1232 VLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP 1290
              G++V Y K+ + +         GN S    LTGL    LY   V A+   G G PS  
Sbjct: 832  PQGFEVGYWKDMEQEDTAETVKTRGNES-FVILTGLEGNTLYHFTVRAYNGAGYGPPS-S 889

Query: 1291 PILERTLDDVPGPPMGILFPEVRTTSVRLIWQP--PAAPNGIILAYQITHR----LNTTT 1344
             +   T    P      L  E + + V L W+P  P A    ++ Y++ +R     N+  
Sbjct: 890  EVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQV 949

Query: 1345 ANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392
              T  ++ + P         L    VY+  + A +  G G A+  + V
Sbjct: 950  IETQKLQAVVP---------LPDAGVYIIEVRAYSEGGDGTASSQIRV 988



 Score =  138 bits (347), Expect = 7e-32
 Identities = 235/1057 (22%), Positives = 403/1057 (38%), Gaps = 115/1057 (10%)

Query: 208  GPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNR 267
            GP     P  II P ++       +V L C     P+      W ++G  +    SD+  
Sbjct: 24   GPVFVQEPDDIIFPTDSD----EKKVALNCEVRGNPVPSYR--WLRNGTEIDLE-SDYRY 76

Query: 268  RLT-----IPNPT-GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAE 321
             L      I NP+   D+G+Y+C A     S+ S  R A L       F       ++  
Sbjct: 77   SLIDGTFIISNPSEAKDSGHYQCLATNTVGSILS--REATLQFAYLGNFSGRTRSAVSVR 134

Query: 322  MEKVVDIPCQAKGVPPPSI-TW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 379
              + V + C      P  I +W + +      E   RF  +  G L IS +   D G + 
Sbjct: 135  EGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYI 194

Query: 380  CFARNAAGEVQTSTYLAVTSIAPNITRG----------PLDSTVIDGMSVVLACETSGAP 429
            C  +N     +  +     ++  +   G          P   T   G +V + C   G P
Sbjct: 195  CLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNP 254

Query: 430  RPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASAD 489
             P ITW K      +G +            L I    + DAG Y C A NSRG +     
Sbjct: 255  VPTITWMK-----VNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQ 309

Query: 490  LVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD 549
            L V+      +   D  +  G+     C  T  PR T R  W K+G  L  +S   +   
Sbjct: 310  LQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYR--WLKNGVPLSPQSRVEMV-- 365

Query: 550  RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAIN 609
             NG L I      D G Y C   +  G    SA L++  L  AP   +  L    ++ I 
Sbjct: 366  -NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI--LASAPTFALNQL----KKTII 418

Query: 610  LTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK-GLVPARSYQFRLCAV 668
            +T  +           ++E     +P   +      +A     +  ++P  S +    + 
Sbjct: 419  VTKDQ---------EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 469

Query: 669  NDVGK------GQFSKDTERVSLPEEPPT----APPQNVIASGRTNQSIMIQWQPPPESH 718
            +D GK        F       SL  + PT     P +  +  G   +SI++  +   ++ 
Sbjct: 470  SDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVG---ESIVLNCKAIHDAS 526

Query: 719  QNGILKGYIIRYCLAGLPVGYQ-----FKNI-TDADVNNLLLEDLIIWTNYEIEVAAYNS 772
             +         + L G P+ ++     F++I   A   +L++ ++++            +
Sbjct: 527  LD-----VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 581

Query: 773  AGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAW 832
            A      S   E  ++G P  PPG V  E    +T   +W+ P+    + I+  Y L A 
Sbjct: 582  ADS---VSDEAELLVRGPPG-PPGIVIVEEITESTATLSWS-PAADNHSPISS-YNLQAR 635

Query: 833  EPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP-QLVRTH 891
             P      T+ T        +       L  + EY   V+     G G  STP +++RT+
Sbjct: 636  SPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTN 695

Query: 892  EDVPGPVG-HLSFSEILDTSLKVSWQEPGEK--NGILTGYRIS--------WEEYNRTNT 940
            E VP     ++S        L ++W+   E+  NG   GY ++        W+E   T++
Sbjct: 696  EAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSS 755

Query: 941  RVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLG 1000
              + ++      YR   +  LT + ++V    +KG G  S   +      E    PT++ 
Sbjct: 756  EASKFI------YRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVK 809

Query: 1001 ISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD 1060
             +++    + + ++     K S+ R     +VG   + E+      +    +   + +  
Sbjct: 810  ATSVSVSEILVAWK---HIKESLGR-PQGFEVGYWKDMEQEDTAETVKTRGNESFVILTG 865

Query: 1061 LNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL 1120
            L   T Y F +R  N  G  PPS       T ++PP  AP+N+       + + L W P+
Sbjct: 866  LEGNTLYHFTVRAYNGAGYGPPSS-EVSATTKKSPPSQAPSNLRWEQQG-SQVSLGWEPV 923

Query: 1121 PEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNA 1180
              +      E VGYK+ Y R +GH    S V++   ++   +  L +   Y ++V+A++ 
Sbjct: 924  --IPLANESEVVGYKVFY-RQEGHSN--SQVIE--TQKLQAVVPLPDAGVYIIEVRAYSE 976

Query: 1181 IGSGPWSQTV-VGRTRESVPSSGPTNVSALATTSSSM 1216
             G G  S  + V        +S  + + +L+T+SSS+
Sbjct: 977  GGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSV 1013



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 100/453 (22%), Positives = 179/453 (39%), Gaps = 45/453 (9%)

Query: 1301 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR----LNTTTANTATVEVLAPS 1356
            PGPP  ++  E+  ++  L W P A  +  I +Y +  R    L   T  T   E++   
Sbjct: 597  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVP-EIITGD 655

Query: 1357 ARQYTATGLKPESVYLFRITAQTRKGWGEAA--EALVVTTEKRDRPQPPSRPMVQQEDVR 1414
                 A  L P   Y FR+ A    G G+ +    ++ T E   +  P +   V     R
Sbjct: 656  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGR 712

Query: 1415 ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASV-SHNASSFIV--DRLKPFTS 1471
               ++++WEP S+       +       P+G        V S  AS FI   + + P T 
Sbjct: 713  RHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP 772

Query: 1472 YKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKIN 1531
            ++ +V   N+ GD  FS+    + + +  P  APT +  T  + + +L+ W+   E    
Sbjct: 773  FEVKVGVYNNKGDGPFSQ-IVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL-- 829

Query: 1532 GILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL-SRPSLTQYELDNLN 1590
            G   GF + Y                      W ++    +   + +R + +   L  L 
Sbjct: 830  GRPQGFEVGY----------------------WKDMEQEDTAETVKTRGNESFVILTGLE 867

Query: 1591 KHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLD 1650
             +  Y   +  YN  G GP S        ++ P+ AP N+       +Q+ + WEP    
Sbjct: 868  GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPL 926

Query: 1651 SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710
            +   ++ GYK+++   Q G+   +V      +  V L +      Y++ V A++  GDG 
Sbjct: 927  ANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDA---GVYIIEVRAYSEGGDGT 981

Query: 1711 RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743
             S+  +  +        +      L+T+S +V+
Sbjct: 982  ASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVT 1014



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 82/349 (23%), Positives = 144/349 (41%), Gaps = 22/349 (6%)

Query: 1086 SRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL-----PEMEYN---GNPESVGYKIK 1137
            S + + L   P   P  V +   +E++  L W P      P   YN    +P S+G++  
Sbjct: 586  SDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV 645

Query: 1138 YSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRE 1196
                    KT+  ++   +E    + DL  W EY  +V A N IG+G P + + + RT E
Sbjct: 646  --------KTVPEIITGDMESAMAV-DLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNE 696

Query: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256
            +VP + PTNVS  +     +++ W  V E  +NG   GY V ++   +       +    
Sbjct: 697  AVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSE 756

Query: 1257 SSRSAQLT-GLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT 1315
            +S+       +     +EV+V  +   GDG  S   ++     +    P  +    V  +
Sbjct: 757  ASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVS 816

Query: 1316 SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRI 1375
             + + W+      G    +++ +  +    +TA       +      TGL+  ++Y F +
Sbjct: 817  EILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTV 876

Query: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEP 1424
             A    G+G  +  +  TT+K    Q PS    +Q+      V L WEP
Sbjct: 877  RAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQ---GSQVSLGWEP 922



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 41/132 (31%), Positives = 65/132 (49%), Gaps = 9/132 (6%)

Query: 1798 RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIA-IHWSSGDPGKGPITR 1856
            R+  R +T       EA +      G PGPPG+ I+   + + A + WS       PI+ 
Sbjct: 573  RYGCRVQTTADSVSDEAELLV---RGPPGPPGIVIVEEITESTATLSWSPAADNHSPISS 629

Query: 1857 YVIEARPSDEGLWDILIKDIPKEVSS---YTFSMDILKPGVSYDFRVIAVNDYGFGTPSS 1913
            Y ++AR      W   +K +P+ ++       ++D L P V Y+FRV+A N  G G PS+
Sbjct: 630  YNLQARSPFSLGWQT-VKTVPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPST 687

Query: 1914 PSQSVPAQKANP 1925
            PS+ +   +A P
Sbjct: 688  PSRMIRTNEAVP 699



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 74/324 (22%), Positives = 121/324 (37%), Gaps = 40/324 (12%)

Query: 1623 PTAAPRNVVVHGATATQLDVTWEPP-----PLDSQNGDIQGYKIYFWEAQRGNLTERVKT 1677
            P   P  V+V   T +   ++W P      P+ S N   +      W+       + V  
Sbjct: 596  PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-----VKTVPE 650

Query: 1678 LFLAE-NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQG-QTQQAAP-SAPSSVKFSE 1734
            +   +  S    +L  +  Y   V A N  G G  STP++  +T +A P +AP++V    
Sbjct: 651  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 710

Query: 1735 LTTTSVNVSWE--APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLA 1792
                 + ++WE  + +F NG   GY + + P        K+VT             +D +
Sbjct: 711  GRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASK----FIYRDES 766

Query: 1793 EGVTYRFRIRAKTFTY---GPEIEANVT-TGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD 1848
                  F ++   +     GP  +  V  +  GE +  P  V       S I + W    
Sbjct: 767  VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 826

Query: 1849 PGKGPITRYVIEARPS--DEGLW-DILIKDIPKEVSSYTFSMDILKPGVS----YDFRVI 1901
               G         RP   + G W D+  +D  + V +      ++  G+     Y F V 
Sbjct: 827  ESLG---------RPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 877

Query: 1902 AVNDYGFGTPSSPSQSVPAQKANP 1925
            A N  G+G PSS   S   +K+ P
Sbjct: 878  AYNGAGYGPPSS-EVSATTKKSPP 900


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score =  274 bits (701), Expect = 6e-73
 Identities = 261/990 (26%), Positives = 409/990 (41%), Gaps = 58/990 (5%)

Query: 23   DVSPYFKTEP--VRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS 80
            D  P F  EP  +      +  ++ L C   G+    ++WL N  E+   S +YRY +  
Sbjct: 96   DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLES-DYRYSLID 154

Query: 81   --------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQ-SVSHGEAAV 131
                     +   +G Y+C+  N +G++L R+  +Q AY+G+F    +   SV  G+  V
Sbjct: 155  GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVV 214

Query: 132  IRAPRIASFPQPQVTW-FRDGRK-IPPSSRIAITLENTLVILSTV-APDAGRYYVQAVND 188
            +        P+   +W F +    +   SR  I+ E   + +S V   D G Y     N 
Sbjct: 215  LMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKNT 274

Query: 189  KNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLH 248
                   S P  LT+ N G   +   P I +    T   A  + V +EC A   P+    
Sbjct: 275  VTNARVLSPPTPLTLRNDGVMGE-YEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPT-- 331

Query: 249  IIWKK-DGVLLSGG-ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE 306
            I W K +G + S   +      L IPN    DAG YEC A   +S   +  RG  L V  
Sbjct: 332  ITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA--ENSRGKNSFRGQ-LQVYT 388

Query: 307  PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQ 366
             P +V E       +    +   C+A G P P+  W K+   V +   +R    N G L 
Sbjct: 389  YPHWV-EKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--VPLSPQSRVEMVN-GVLM 444

Query: 367  ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI--DGMSVVLACE 424
            I  +   D GM+QC A N  G +  S  L + + AP      L  T+I      VV+ C+
Sbjct: 445  IHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECK 504

Query: 425  TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
              G+P+P I+W+KG+R +        R   L  GSL I     SD G Y C   N  G  
Sbjct: 505  PQGSPKPTISWKKGDRAVRENK----RIAILPDGSLRILNASKSDEGKYVCRGENVFGSA 560

Query: 485  EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESH- 543
            E  A L V   TRI   P+   +  G    + C   HD  + + + W   G  +  E   
Sbjct: 561  EIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEG 620

Query: 544  ---PRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVAT 599
                 IR   + + L I        G Y CRV +   + S  A L VR  P  P   +  
Sbjct: 621  GHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRGPPGPPG--IVI 678

Query: 600  LSTVERRAINLTWTKPFDGNSPLIRYILEM-SENNAPWTVLLAS---VDPKATSVTVKGL 655
            +  +      L+W+   D +SP+  Y L+  S  +  W  +      +     S     L
Sbjct: 679  VEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDL 738

Query: 656  VPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPP 715
             P   Y+FR+ A N +G G  S  +  +   E  P   P NV         ++I W+P  
Sbjct: 739  NPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVIAWEPVS 798

Query: 716  ESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLII--WTNYEIEVAAYNSA 773
            E  QNG   GYI+ +   G   G++ K +T ++ +  +  D  +   T +E++V  YN+ 
Sbjct: 799  EEFQNGEGFGYIVAFRPNGTR-GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNK 857

Query: 774  GLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWE 833
            G G +S  V   + +G P+  P +V A + + + I   W         G  QG+++  W+
Sbjct: 858  GDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL--GRPQGFEVGYWK 915

Query: 834  PEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHED 893
             + E+E T  T +    +S  +  ++GL+  T Y  +V  +   G GP S+     T + 
Sbjct: 916  -DMEQEDTAETVKTRGNESFVI--LTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKS 972

Query: 894  VPGPVGHLSFSEILDTSLKVSWQE--PGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTL 951
             P         E   + + + W+   P      + GY++ + +   +N++V   +    L
Sbjct: 973  PPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQV---IETQKL 1029

Query: 952  EYRVTGLTALTTYTIEVAAMTSKGQGQVSA 981
            +  V  L     Y IEV A +  G G  S+
Sbjct: 1030 Q-AVVPLPDAGVYIIEVRAYSEGGDGTASS 1058



 Score =  142 bits (357), Expect = 5e-33
 Identities = 114/384 (29%), Positives = 185/384 (48%), Gaps = 38/384 (9%)

Query: 1385 EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPS 1444
            + AE LV     R  P PP   +V  E++   +  LSW P +D  SP+  Y +Q R   S
Sbjct: 661  DEAELLV-----RGPPGPPGIVIV--EEITESTATLSWSPAADNHSPISSYNLQARSPFS 713

Query: 1445 GRWALHSAS---VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501
              W         ++ +  S +   L P+  Y+FRV ATN IG  + S  S  + T +A P
Sbjct: 714  LGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVP 773

Query: 1502 DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
              APT +S        ++I W+P +E+  NG   G+ + +R     G RG+  + + +  
Sbjct: 774  KTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRP---NGTRGWKEKMVTSSE 830

Query: 1562 ATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEA 1621
            A      S +  R+ S P LT            +E+++ VYN  G+GP S    +   E 
Sbjct: 831  A------SKFIYRDESVPPLTP-----------FEVKVGVYNNKGDGPFSQIVVICSAEG 873

Query: 1622 VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFW-EAQRGNLTERVKTLFL 1680
             P+AAP +V     + +++ V W+   +    G  QG+++ +W + ++ +  E VKT   
Sbjct: 874  EPSAAPTDVKATSVSVSEILVAWK--HIKESLGRPQGFEVGYWKDMEQEDTAETVKTRG- 930

Query: 1681 AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS-APSSVKFSELTTTS 1739
             E+ V L  L G T Y  +V A+N AG GP S+     T+++ PS APS++++ E   + 
Sbjct: 931  NESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRW-EQQGSQ 989

Query: 1740 VNVSWE--APQFPNGILEGYRLVY 1761
            V++ WE   P      + GY++ Y
Sbjct: 990  VSLGWEPVIPLANESEVVGYKVFY 1013



 Score =  139 bits (351), Expect = 2e-32
 Identities = 118/408 (28%), Positives = 180/408 (44%), Gaps = 24/408 (5%)

Query: 993  PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPD 1052
            PGPP  + +  I   + TL + P  D  + IS + ++A+       +    + ++    D
Sbjct: 671  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITG-D 729

Query: 1053 ARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETS 1112
              S    DLNP+  Y FR+   N +GT  PS PSR I+T +A P  AP NVS R+     
Sbjct: 730  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHE 789

Query: 1113 LWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER-DYTIEDLEEWTEY 1171
            L + W P+ E   NG  E  GY + +  +   G     V      +  Y  E +   T +
Sbjct: 790  LVIAWEPVSEEFQNG--EGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPF 847

Query: 1172 RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGL 1231
             V+V  +N  G GP+SQ VV  + E  PS+ PT+V A + + S +LV W  + E+   G 
Sbjct: 848  EVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKES--LGR 905

Query: 1232 VLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP 1290
              G++V Y K+ + +         GN S    LTGL    LY   V A+   G G PS  
Sbjct: 906  PQGFEVGYWKDMEQEDTAETVKTRGNES-FVILTGLEGNTLYHFTVRAYNGAGYGPPS-S 963

Query: 1291 PILERTLDDVPGPPMGILFPEVRTTSVRLIWQP--PAAPNGIILAYQITHR----LNTTT 1344
             +   T    P      L  E + + V L W+P  P A    ++ Y++ +R     N+  
Sbjct: 964  EVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSNSQV 1023

Query: 1345 ANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392
              T  ++ + P         L    VY+  + A +  G G A+  + V
Sbjct: 1024 IETQKLQAVVP---------LPDAGVYIIEVRAYSEGGDGTASSQIRV 1062



 Score =  138 bits (347), Expect = 7e-32
 Identities = 235/1057 (22%), Positives = 403/1057 (38%), Gaps = 115/1057 (10%)

Query: 208  GPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNR 267
            GP     P  II P ++       +V L C     P+      W ++G  +    SD+  
Sbjct: 98   GPVFVQEPDDIIFPTDSD----EKKVALNCEVRGNPVPSYR--WLRNGTEIDLE-SDYRY 150

Query: 268  RLT-----IPNPT-GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAE 321
             L      I NP+   D+G+Y+C A     S+ S  R A L       F       ++  
Sbjct: 151  SLIDGTFIISNPSEAKDSGHYQCLATNTVGSILS--REATLQFAYLGNFSGRTRSAVSVR 208

Query: 322  MEKVVDIPCQAKGVPPPSI-TW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 379
              + V + C      P  I +W + +      E   RF  +  G L IS +   D G + 
Sbjct: 209  EGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYI 268

Query: 380  CFARNAAGEVQTSTYLAVTSIAPNITRG----------PLDSTVIDGMSVVLACETSGAP 429
            C  +N     +  +     ++  +   G          P   T   G +V + C   G P
Sbjct: 269  CLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNP 328

Query: 430  RPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASAD 489
             P ITW K      +G +            L I    + DAG Y C A NSRG +     
Sbjct: 329  VPTITWMK-----VNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQ 383

Query: 490  LVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD 549
            L V+      +   D  +  G+     C  T  PR T R  W K+G  L  +S   +   
Sbjct: 384  LQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYR--WLKNGVPLSPQSRVEMV-- 439

Query: 550  RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAIN 609
             NG L I      D G Y C   +  G    SA L++  L  AP   +  L    ++ I 
Sbjct: 440  -NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI--LASAPTFALNQL----KKTII 492

Query: 610  LTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK-GLVPARSYQFRLCAV 668
            +T  +           ++E     +P   +      +A     +  ++P  S +    + 
Sbjct: 493  VTKDQ---------EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASK 543

Query: 669  NDVGK------GQFSKDTERVSLPEEPPT----APPQNVIASGRTNQSIMIQWQPPPESH 718
            +D GK        F       SL  + PT     P +  +  G   +SI++  +   ++ 
Sbjct: 544  SDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVG---ESIVLNCKAIHDAS 600

Query: 719  QNGILKGYIIRYCLAGLPVGYQ-----FKNI-TDADVNNLLLEDLIIWTNYEIEVAAYNS 772
             +         + L G P+ ++     F++I   A   +L++ ++++            +
Sbjct: 601  LD-----VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTT 655

Query: 773  AGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAW 832
            A      S   E  ++G P  PPG V  E    +T   +W+ P+    + I+  Y L A 
Sbjct: 656  ADS---VSDEAELLVRGPPG-PPGIVIVEEITESTATLSWS-PAADNHSPISS-YNLQAR 709

Query: 833  EPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTP-QLVRTH 891
             P      T+ T        +       L  + EY   V+     G G  STP +++RT+
Sbjct: 710  SPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTN 769

Query: 892  EDVPGPVG-HLSFSEILDTSLKVSWQEPGEK--NGILTGYRIS--------WEEYNRTNT 940
            E VP     ++S        L ++W+   E+  NG   GY ++        W+E   T++
Sbjct: 770  EAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSS 829

Query: 941  RVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLG 1000
              + ++      YR   +  LT + ++V    +KG G  S   +      E    PT++ 
Sbjct: 830  EASKFI------YRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVK 883

Query: 1001 ISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD 1060
             +++    + + ++     K S+ R     +VG   + E+      +    +   + +  
Sbjct: 884  ATSVSVSEILVAWK---HIKESLGR-PQGFEVGYWKDMEQEDTAETVKTRGNESFVILTG 939

Query: 1061 LNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL 1120
            L   T Y F +R  N  G  PPS       T ++PP  AP+N+       + + L W P+
Sbjct: 940  LEGNTLYHFTVRAYNGAGYGPPSS-EVSATTKKSPPSQAPSNLRWEQQG-SQVSLGWEPV 997

Query: 1121 PEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNA 1180
              +      E VGYK+ Y R +GH    S V++   ++   +  L +   Y ++V+A++ 
Sbjct: 998  --IPLANESEVVGYKVFY-RQEGHSN--SQVIE--TQKLQAVVPLPDAGVYIIEVRAYSE 1050

Query: 1181 IGSGPWSQTV-VGRTRESVPSSGPTNVSALATTSSSM 1216
             G G  S  + V        +S  + + +L+T+SSS+
Sbjct: 1051 GGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSV 1087



 Score = 95.1 bits (235), Expect = 7e-19
 Identities = 100/453 (22%), Positives = 179/453 (39%), Gaps = 45/453 (9%)

Query: 1301 PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHR----LNTTTANTATVEVLAPS 1356
            PGPP  ++  E+  ++  L W P A  +  I +Y +  R    L   T  T   E++   
Sbjct: 671  PGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVP-EIITGD 729

Query: 1357 ARQYTATGLKPESVYLFRITAQTRKGWGEAA--EALVVTTEKRDRPQPPSRPMVQQEDVR 1414
                 A  L P   Y FR+ A    G G+ +    ++ T E   +  P +   V     R
Sbjct: 730  MESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTN---VSGRSGR 786

Query: 1415 ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASV-SHNASSFIV--DRLKPFTS 1471
               ++++WEP S+       +       P+G        V S  AS FI   + + P T 
Sbjct: 787  RHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP 846

Query: 1472 YKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKIN 1531
            ++ +V   N+ GD  FS+    + + +  P  APT +  T  + + +L+ W+   E    
Sbjct: 847  FEVKVGVYNNKGDGPFSQ-IVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIKESL-- 903

Query: 1532 GILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL-SRPSLTQYELDNLN 1590
            G   GF + Y                      W ++    +   + +R + +   L  L 
Sbjct: 904  GRPQGFEVGY----------------------WKDMEQEDTAETVKTRGNESFVILTGLE 941

Query: 1591 KHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLD 1650
             +  Y   +  YN  G GP S        ++ P+ AP N+       +Q+ + WEP    
Sbjct: 942  GNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWE-QQGSQVSLGWEPVIPL 1000

Query: 1651 SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710
            +   ++ GYK+++   Q G+   +V      +  V L +      Y++ V A++  GDG 
Sbjct: 1001 ANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDA---GVYIIEVRAYSEGGDGT 1055

Query: 1711 RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVS 1743
             S+  +  +        +      L+T+S +V+
Sbjct: 1056 ASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVT 1088



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 82/349 (23%), Positives = 144/349 (41%), Gaps = 22/349 (6%)

Query: 1086 SRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPL-----PEMEYN---GNPESVGYKIK 1137
            S + + L   P   P  V +   +E++  L W P      P   YN    +P S+G++  
Sbjct: 660  SDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTV 719

Query: 1138 YSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRE 1196
                    KT+  ++   +E    + DL  W EY  +V A N IG+G P + + + RT E
Sbjct: 720  --------KTVPEIITGDMESAMAV-DLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNE 770

Query: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256
            +VP + PTNVS  +     +++ W  V E  +NG   GY V ++   +       +    
Sbjct: 771  AVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSE 830

Query: 1257 SSRSAQLT-GLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT 1315
            +S+       +     +EV+V  +   GDG  S   ++     +    P  +    V  +
Sbjct: 831  ASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVS 890

Query: 1316 SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRI 1375
             + + W+      G    +++ +  +    +TA       +      TGL+  ++Y F +
Sbjct: 891  EILVAWKHIKESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTV 950

Query: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEP 1424
             A    G+G  +  +  TT+K    Q PS    +Q+      V L WEP
Sbjct: 951  RAYNGAGYGPPSSEVSATTKKSPPSQAPSNLRWEQQ---GSQVSLGWEP 996



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 41/132 (31%), Positives = 65/132 (49%), Gaps = 9/132 (6%)

Query: 1798 RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIA-IHWSSGDPGKGPITR 1856
            R+  R +T       EA +      G PGPPG+ I+   + + A + WS       PI+ 
Sbjct: 647  RYGCRVQTTADSVSDEAELLV---RGPPGPPGIVIVEEITESTATLSWSPAADNHSPISS 703

Query: 1857 YVIEARPSDEGLWDILIKDIPKEVSS---YTFSMDILKPGVSYDFRVIAVNDYGFGTPSS 1913
            Y ++AR      W   +K +P+ ++       ++D L P V Y+FRV+A N  G G PS+
Sbjct: 704  YNLQARSPFSLGWQT-VKTVPEIITGDMESAMAVD-LNPWVEYEFRVVATNPIGTGDPST 761

Query: 1914 PSQSVPAQKANP 1925
            PS+ +   +A P
Sbjct: 762  PSRMIRTNEAVP 773



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 74/324 (22%), Positives = 121/324 (37%), Gaps = 40/324 (12%)

Query: 1623 PTAAPRNVVVHGATATQLDVTWEPP-----PLDSQNGDIQGYKIYFWEAQRGNLTERVKT 1677
            P   P  V+V   T +   ++W P      P+ S N   +      W+       + V  
Sbjct: 670  PPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQT-----VKTVPE 724

Query: 1678 LFLAE-NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQG-QTQQAAP-SAPSSVKFSE 1734
            +   +  S    +L  +  Y   V A N  G G  STP++  +T +A P +AP++V    
Sbjct: 725  IITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRS 784

Query: 1735 LTTTSVNVSWE--APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLA 1792
                 + ++WE  + +F NG   GY + + P        K+VT             +D +
Sbjct: 785  GRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASK----FIYRDES 840

Query: 1793 EGVTYRFRIRAKTFTY---GPEIEANVT-TGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD 1848
                  F ++   +     GP  +  V  +  GE +  P  V       S I + W    
Sbjct: 841  VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK 900

Query: 1849 PGKGPITRYVIEARPS--DEGLW-DILIKDIPKEVSSYTFSMDILKPGVS----YDFRVI 1901
               G         RP   + G W D+  +D  + V +      ++  G+     Y F V 
Sbjct: 901  ESLG---------RPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVR 951

Query: 1902 AVNDYGFGTPSSPSQSVPAQKANP 1925
            A N  G+G PSS   S   +K+ P
Sbjct: 952  AYNGAGYGPPSS-EVSATTKKSPP 974


>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
            [Homo sapiens]
          Length = 1224

 Score =  270 bits (690), Expect = 1e-71
 Identities = 244/953 (25%), Positives = 418/953 (43%), Gaps = 78/953 (8%)

Query: 87   GFYRCIVRNRMGALLQRQTEVQVAYMGSF-EEGEKHQSVSHGEAAVIRAPRIASFPQPQV 145
            G YRC   N++G  +  + E  V  +  F +E      V  G+  V+        P   +
Sbjct: 105  GKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLPPLHI 164

Query: 146  TWFR-DGRKIPPSSRIAITLENTLVILSTVAPDAGR-YYVQAVNDKNGDNKTSQPITLTV 203
             W   +   I    R+ ++ +  L   +    D+   Y   A   +        P+ LTV
Sbjct: 165  YWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKMPMKLTV 224

Query: 204  EN------------VGGPADPIA---PTIIIPP----KNTSVVAGTSEVTL-ECVANARP 243
             +            +G  A+ I    P +++PP      +S+     E+ L EC A   P
Sbjct: 225  NSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLLECFAEGLP 284

Query: 244  LIKLHIIWKKDGVLLSGGIS---DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA 300
              ++   W K G  L  G     ++ + L I N +  D G Y C A   S+ + +     
Sbjct: 285  TPQVD--WNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTA---SNFLGTATHDF 339

Query: 301  YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR---F 357
            ++ V EPP++ K+P+  + +     + + C+A+G P P+I W  + + V+         F
Sbjct: 340  HVIVEEPPRWTKKPQSAVYSTGSNGI-LLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVF 398

Query: 358  RQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDG 416
             +     +  + L P+ T ++QC A N  G +  +  + V  + P I T+   +   + G
Sbjct: 399  PRE----ISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVVG 454

Query: 417  MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
             S  L CE   +P   ++WQK E +     ++  R+   E+G+L I+ T   DAG+Y+C 
Sbjct: 455  YSAFLHCEFFASPEAVVSWQKVEEVKP---LEGRRYHIYENGTLQINRTTEEDAGSYSCW 511

Query: 477  ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV--TIRYIWEKD 534
              N+ G    +A+L +   T++   P++  + K     + C    D  +  +++  W KD
Sbjct: 512  VENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKLSWSKD 571

Query: 535  GATL---GTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPH 591
            G      GTE   RI +D   +L IS     D G Y C   +A  + +    + V  +P 
Sbjct: 572  GEAFEINGTEDG-RIIID-GANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPD 629

Query: 592  APEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAP---WTVLLASVDPKAT 648
             PE+    LS  + R++ LTW    D NS +  YI+E   N      W  L   V  K T
Sbjct: 630  PPEN--LHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEEL-TRVQGKKT 686

Query: 649  SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIM 708
            +V +  L P   YQFR+ AVN+VG+ Q S+ ++    P   P   PQN+       + ++
Sbjct: 687  TVILP-LAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMI 745

Query: 709  IQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768
            I+W+P     QNG    Y + +   G PV ++ + +T+   + L +    ++  Y+++V 
Sbjct: 746  IKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTN---HTLRVMTPAVYAPYDVKVQ 802

Query: 769  AYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYK 828
            A N  G G     VT ++ +  P   P     +  NST ++ TW+      ++G  +GY+
Sbjct: 803  AINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQ 862

Query: 829  LIAWEPE-------QEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGP 881
            +  W+ +         +EV ++     F    + G V  L  F+E+  +VL + + G GP
Sbjct: 863  INWWKTKSLLDGRTHPKEVNIL----RFSGQRNSGMVPSLDAFSEFHLTVLAYNSKGAGP 918

Query: 882  RSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTR 941
             S P + +T E VP     L   ++   +  +SW  P + NG LTGY + ++  N T   
Sbjct: 919  ESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYEI 978

Query: 942  VTHYLPNVTL----EYRVTGLTALTTYTIEVAAMTSKGQGQ---VSASTISSG 987
                  N+T      + ++ L A T Y   + A TS+G G+     +ST+  G
Sbjct: 979  GELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESSTLGEG 1031



 Score =  156 bits (395), Expect = 2e-37
 Identities = 164/702 (23%), Positives = 285/702 (40%), Gaps = 133/702 (18%)

Query: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQ---TRELPSGRWALHSASV 1454
            D P PP    + +   + RSV L+WE G+D  S +  Y ++    +E P GRW     + 
Sbjct: 626  DVPDPPENLHLSER--QNRSVRLTWEAGADHNSNISEYIVEFEGNKEEP-GRW--EELTR 680

Query: 1455 SHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHT 1514
                 + ++  L PF  Y+FRV A N++G S+ S+ S+   T  AAPD  P  + V    
Sbjct: 681  VQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQ 740

Query: 1515 TTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMR 1574
               ++I+W+P    + NG  L +R+ ++                     W E T      
Sbjct: 741  PKEMIIKWEPLKSMEQNGPGLEYRVTWKP--------------QGAPVEWEEETVTNHTL 786

Query: 1575 NLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHG 1634
             +  P++          +  Y++++   N +G GP      ++ GE  P  AP   V+HG
Sbjct: 787  RVMTPAV----------YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP---VIHG 833

Query: 1635 A---TATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR----GNLTERVKTLFLA--ENSV 1685
                 +T + VTW   P D  +G ++GY+I +W+ +         + V  L  +   NS 
Sbjct: 834  VDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSG 893

Query: 1686 KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE 1745
             + +L  ++ + ++V A+N+ G GP S P   QT +  P  P+ +K  ++   +  +SW 
Sbjct: 894  MVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWG 953

Query: 1746 APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNS-PLWLKVKDLAEGVTYRFRIRAK 1804
             P+  NG L GY L Y+  +    + ++  +++   S P W  + +L     Y+F +RA 
Sbjct: 954  LPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSW-HLSNLNATTKYKFYLRA- 1011

Query: 1805 TFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPS 1864
                         T  G G P       I   SS +      G  G G I+         
Sbjct: 1012 ------------CTSQGCGKP-------ITEESSTL----GEGSKGIGKISGV------- 1041

Query: 1865 DEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKAN 1924
                           ++  T  +++ +PG  +  R++  N   +G   S  Q V   +  
Sbjct: 1042 --------------NLTQKTHPIEVFEPGAEHIVRLMTKN---WGDNDSIFQDVIETRGR 1084

Query: 1925 PF---YE----EWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALGH 1977
             +   Y+    + WF+ ++  + L+ +LLL    + R +  KY+ K       K      
Sbjct: 1085 EYAGLYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVK------EKEDLHPD 1138

Query: 1978 SEMMSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDV--TKYND 2035
             E+ S+ + +F                    G Y+ S  +P  GSL   + D+  T+  D
Sbjct: 1139 PEIQSVKDETF--------------------GEYSDSDEKPLKGSLRSLNRDMQPTESAD 1178

Query: 2036 LI----PAESSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSF 2073
             +      +    +E  S I    GS  +  V+SN     +F
Sbjct: 1179 SLVEYGEGDHGLFSEDGSFIGAYAGSKEKGSVESNGSSTATF 1220



 Score =  149 bits (377), Expect = 2e-35
 Identities = 138/491 (28%), Positives = 215/491 (43%), Gaps = 43/491 (8%)

Query: 907  LDTSLKVSWQEPGEK---NGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTT 963
            L  SLK+SW + GE    NG   G RI  +  N T       + NVTLE +  G+   + 
Sbjct: 560  LKHSLKLSWSKDGEAFEINGTEDG-RIIIDGANLT-------ISNVTLEDQ--GIYCCSA 609

Query: 964  YTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSI 1023
            +T              SA+ I+     ++P PP NL +S    RSV L +  G D  ++I
Sbjct: 610  HT-----------ALDSAADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNI 658

Query: 1024 SRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPS 1083
            S ++VE +    G  EE     +L+     ++  +  L PF  Y FR+  VN VG S PS
Sbjct: 659  SEYIVEFE----GNKEEPGRWEELTRVQGKKTTVILPLAPFVRYQFRVIAVNEVGRSQPS 714

Query: 1084 QPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDG 1143
            QPS   +T  A PD  P N+ ++ +    + ++W PL  ME NG    + Y++ +     
Sbjct: 715  QPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNG--PGLEYRVTWKPQGA 772

Query: 1144 HGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGP 1203
              +     V +   R  T      +  Y V+VQA N +GSGP  Q+V   + E  P + P
Sbjct: 773  PVEWEEETVTNHTLRVMT---PAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP 829

Query: 1204 TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSR---- 1259
                     S+ + V WS VP+   +G + GY++ + +  S    R    E N  R    
Sbjct: 830  VIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQ 889

Query: 1260 --SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSV 1317
              S  +  L  +  + + VLA+   G G  S P I + T + VP  P  +   +V   + 
Sbjct: 890  RNSGMVPSLDAFSEFHLTVLAYNSKGAGPESEPYIFQ-TPEGVPEQPTFLKVIKVDKDTA 948

Query: 1318 RLIWQPPAAPNGIILAYQITHRLNTTT---ANTATVEVLAPSARQYTATGLKPESVYLFR 1374
             L W  P   NG +  Y + +++   T        + +  PS   +  + L   + Y F 
Sbjct: 949  TLSWGLPKKLNGNLTGYLLQYQIINDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFY 1008

Query: 1375 ITAQTRKGWGE 1385
            + A T +G G+
Sbjct: 1009 LRACTSQGCGK 1019



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 81/306 (26%), Positives = 117/306 (38%), Gaps = 35/306 (11%)

Query: 30  TEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTK--------FSLEYRYMITSL 81
           T+  ++ V+  G+  +L C AEG      KW  N   +          F  E  +  T+L
Sbjct: 350 TKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPFAGDVVFPREISF--TNL 407

Query: 82  DRTHAGFYRCIVRNRMGALLQRQT--EVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIAS 139
              H   Y+C   N  G +L       V V  +   ++GE + +V  G +A +     AS
Sbjct: 408 QPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYATVV-GYSAFLHCEFFAS 466

Query: 140 FPQPQVTWFRDGRKIPPSSRIAITLEN-TLVILSTVAPDAGRYYVQAVNDKNGDNKTSQP 198
            P+  V+W +     P   R     EN TL I  T   DAG Y       +N   KT+  
Sbjct: 467 -PEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSYSCWV---ENAIGKTAVT 522

Query: 199 ITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIK--LHIIWKKDGV 256
             L + N        A  + + PKN   +     + L C +     +K  L + W KDG 
Sbjct: 523 ANLDIRN--------ATKLRVSPKNPR-IPKLHMLELHCESKCDSHLKHSLKLSWSKDGE 573

Query: 257 LL------SGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQF 310
                    G I      LTI N T  D G Y C A     S   + +   L V +PP+ 
Sbjct: 574 AFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTVLDVPDPPEN 633

Query: 311 VKEPER 316
           +   ER
Sbjct: 634 LHLSER 639



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 74/347 (21%), Positives = 121/347 (34%), Gaps = 48/347 (13%)

Query: 303 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 362
           SV + P  +K+ +  +    ++   I C+AKG P P+ +W KD               N 
Sbjct: 30  SVQQVPTIIKQSKVQVAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNS 89

Query: 363 GGLQI--SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS-TVIDGMSV 419
           G  +I   G +    G ++CFA N  G   +     +    P   +  +D   V +G  +
Sbjct: 90  GTFRIPNEGHISHFQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPI 149

Query: 420 VLACE-TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDA-GTYTCLA 477
           VL C    G P   I W     I      Q  R    + G L  +     D+   Y C A
Sbjct: 150 VLPCNPPKGLPPLHIYWM---NIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFA 206

Query: 478 TNSR-------------------GVDEAS-------ADLVVWARTRITKPPQDQ------ 505
              R                     D +S       A+ +   + ++  PP +       
Sbjct: 207 AFPRLRTIVQKMPMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSI 266

Query: 506 SVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL--GTESHPRIRLDRNGSLHISQTWSGD 563
           +++KG    + C     P  T +  W K G  L  G E+    + +   +L I      D
Sbjct: 267 TILKGEILLLECFAEGLP--TPQVDWNKIGGDLPKGRET----KENYGKTLKIENVSYQD 320

Query: 564 IGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINL 610
            G Y C   +  G  +   H+ V + P   + P + + +     I L
Sbjct: 321 KGNYRCTASNFLGTATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILL 367



 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 35/115 (30%), Positives = 53/115 (46%), Gaps = 7/115 (6%)

Query: 1814 ANVTTGPGEGAPGPP-GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDE--GLWD 1870
            A++T       P PP  + +  R + ++ + W +G      I+ Y++E   + E  G W+
Sbjct: 617  ADITQVTVLDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWE 676

Query: 1871 ILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
             L +   K+    T  +  L P V Y FRVIAVN+ G   PS PS       A P
Sbjct: 677  ELTRVQGKK----TTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAP 727


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score =  264 bits (674), Expect = 8e-70
 Identities = 290/1109 (26%), Positives = 466/1109 (42%), Gaps = 119/1109 (10%)

Query: 198  PITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVL 257
            P  + +  V G      P  I  P++ + ++G    +  C A   P  K  I W K G  
Sbjct: 16   PALVMLGLVAGAHGDSKPVFIKVPEDQTGLSG-GVASFVCQATGEP--KPRITWMKKGKK 72

Query: 258  LSGGISDHNRRLTIPNPTGS-----------DAGYYECEAVLRSSSVPSVVRGAYLSVLE 306
            +S   S     +   +  GS           D   YEC A   ++S+  +   A LSVLE
Sbjct: 73   VS---SQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTA---TNSLGEINTSAKLSVLE 126

Query: 307  ----PPQFVK---EPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT-RFR 358
                PP F      P+  +  E  +   + C A G P P I+W+KD   V+      R +
Sbjct: 127  EEQLPPGFPSIDMGPQLKVV-EKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIK 185

Query: 359  QRNDGGLQISGLVPDDTGMFQCFARNAAG---EVQTSTYLAVTSIAPNITRGPLDSTVID 415
            Q   G LQI      D G ++C A N+AG       + Y+ V  +AP  +  P    V+ 
Sbjct: 186  QLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMP 245

Query: 416  GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTC 475
            G SV L C   GAP P + W  G         +L +   +  G  ++  +++  +  YTC
Sbjct: 246  GGSVNLTCVAVGAPMPYVKWMMGAE-------ELTKEDEMPVGRNVLELSNVVRSANYTC 298

Query: 476  LATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDG 535
            +A +S G+ EA+A + V A   + KPP D  V + T  S+           + Y   +  
Sbjct: 299  VAISSLGMIEATAQVTVKA---LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYR 355

Query: 536  ATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG--GNDSRSAHLRVRQLPHAP 593
            A  GTE  P   +D   +   S         Y  RV++    G    S  +R R    AP
Sbjct: 356  AA-GTEG-PFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAP 413

Query: 594  EHPVATLST--VERRAINLTWTKPFDGNSPLIRY-ILEMSENNAPWTVLLASVDPKATSV 650
              P   +    +    + + W  P + N  +  Y +    ++  P               
Sbjct: 414  SSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLT 473

Query: 651  TVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQ 710
            TV  L+P  +Y  R+ A   VG G  S  T +V   +  P A P +  A   ++  I + 
Sbjct: 474  TVGSLLPGITYSLRVLAFTAVGDGPPSP-TIQVKTQQGVP-AQPADFQAEVESDTRIQLS 531

Query: 711  WQPPPESHQNGILKGYIIRYCL---AGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEV 767
            W  PP+          II Y L   A      Q K +T    ++  LEDL   T Y  ++
Sbjct: 532  WLLPPQER--------IIMYELVYWAAEDEDQQHK-VTFDPTSSYTLEDLKPDTLYRFQL 582

Query: 768  AAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGI---- 823
            AA +  G+GV++  +   T Q  P+ PP  V   +  STT+R +W  P     NG+    
Sbjct: 583  AARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQY 642

Query: 824  NQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRS 883
            +  Y+ +  E      V  ++   +  D +      GL+K+TEY   V   T  G GP S
Sbjct: 643  SVAYEAVDGEDRGRHVVDGISREHSSWDLV------GLEKWTEYRVWVRAHTDVGPGPES 696

Query: 884  TPQLVRTHEDVP-GPVGHLSFSEILDTSLKVSWQ--EPGEKNGILTGYRISWEEYNRTNT 940
            +P LVRT EDVP GP   +    +  T++ V W+   P +++G + GY++++        
Sbjct: 697  SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEP 756

Query: 941  RVTHYLPNVTL----EYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPP 996
            R    + +V L    E  ++GLT  TTY++ VAA T+KG G  S   I +     +PG P
Sbjct: 757  RGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVT-TTGAVPGRP 815

Query: 997  TNLGISNIGPRSVTLQFRPGYDGKTSISRWLV------EAQVGVVGEGEEWLLIHQLSNE 1050
            T + IS     +  LQ+ P  +    +  + +      EA+   +  G+           
Sbjct: 816  TMM-ISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGK----------- 863

Query: 1051 PDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASE 1110
             D +   V  L+  T Y FR+   N  G     +  ++I+T +  P   P N+ +   + 
Sbjct: 864  -DDQHFTVTGLHKGTTYIFRLAAKNRAGLG--EEFEKEIRTPEDLPSGFPQNLHVTGLTT 920

Query: 1111 TSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTE 1170
            ++  L W P    E NG    + Y + + R     + L ++  D     +T+  L+  T 
Sbjct: 921  STTELAWDPPVLAERNG--RIISYTVVF-RDINSQQELQNITTD---TRFTLTGLKPDTT 974

Query: 1171 YRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNG 1230
            Y ++V+A+ + GSGP S ++  RT   V      N    A   +S+L+ W EVP++ ++ 
Sbjct: 975  YDIKVRAWTSKGSGPLSPSIQSRTM-PVEQVFAKNFRVAAAMKTSVLLSW-EVPDSYKS- 1031

Query: 1231 LVLGYKVMYKEKDSDTQPRFWLVEGNSSR 1259
              + +K++Y  +  +       V+G+S R
Sbjct: 1032 -AVPFKILYNGQSVE-------VDGHSMR 1052



 Score =  212 bits (540), Expect = 3e-54
 Identities = 199/766 (25%), Positives = 326/766 (42%), Gaps = 61/766 (7%)

Query: 890  THEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNV 949
            T + +P P   L  +E   TS+ ++W     +   +T Y I +     T           
Sbjct: 314  TVKALPKPPIDLVVTETTATSVTLTWDSGNSEP--VTYYGIQYRAAG-TEGPFQEVDGVA 370

Query: 950  TLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSV 1009
            T  Y + GL+  + Y   V A+ S G+G  S +  +         PP  +    +   ++
Sbjct: 371  TTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTM 430

Query: 1010 TLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSF 1069
             +Q+ P  +    +  + V            W       N        V  L P   YS 
Sbjct: 431  LVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW----HKHNTDAGLLTTVGSLLPGITYSL 486

Query: 1070 RMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNP 1129
            R+     VG  PPS P+ +++T Q  P   PA+      S+T + L W+ LP  E     
Sbjct: 487  RVLAFTAVGDGPPS-PTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWL-LPPQE----- 538

Query: 1130 ESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQT 1189
              + Y++ Y  ++   +   H V       YT+EDL+  T YR Q+ A + +G G ++ T
Sbjct: 539  RIIMYELVYWAAEDEDQ--QHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596

Query: 1190 VVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPR 1249
            +  RT +S PS+ P  V  ++  S+++ V W   P   RNG++  Y V Y+  D + + R
Sbjct: 597  IEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR 656

Query: 1250 FWLVEGNSSR--SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVP-GPPMG 1306
              +V+G S    S  L GL K+  Y V V A T +G G P   P+L RT +DVP GPP  
Sbjct: 657  H-VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPSGPPRK 714

Query: 1307 ILFPEVRTTSVRLIWQ--PPAAPNGIILAYQITH-RLNTTTANTATV--EVLAPSARQYT 1361
            +    + +T+V + W+   P+  +G I  YQ+T+ RL         +  +V+   A++ T
Sbjct: 715  VEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETT 774

Query: 1362 ATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLS 1421
             +GL PE+ Y   + A T KG G  ++  +VTT        P RP +        + LL 
Sbjct: 775  ISGLTPETTYSVTVAAYTTKGDGARSKPKIVTT----TGAVPGRPTMMISTTAMNTALLQ 830

Query: 1422 WEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATND 1481
            W P  +    +  Y +Q       R   ++     +   F V  L   T+Y FR+ A N 
Sbjct: 831  WHPPKELPGELLGYRLQYCRADEAR--PNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 888

Query: 1482 IGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY 1541
             G  E  E  + + T +  P   P  L VT  TT++  + W PP   + NG ++ + + +
Sbjct: 889  AGLGE--EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF 946

Query: 1542 RELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSV 1601
            R                       ++ S   ++N++    T++ L  L     Y+I++  
Sbjct: 947  R-----------------------DINSQQELQNITTD--TRFTLTGLKPDTTYDIKVRA 981

Query: 1602 YNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPP 1647
            + + G GP SP  +      V     +N  V  A  T + ++WE P
Sbjct: 982  WTSKGSGPLSPSIQSRT-MPVEQVFAKNFRVAAAMKTSVLLSWEVP 1026



 Score =  206 bits (524), Expect = 2e-52
 Identities = 192/740 (25%), Positives = 316/740 (42%), Gaps = 78/740 (10%)

Query: 1203 PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQ 1262
            P ++    TT++S+ + W    ++  +  V  Y + Y+   + T+  F  V+G ++    
Sbjct: 322  PIDLVVTETTATSVTLTW----DSGNSEPVTYYGIQYRA--AGTEGPFQEVDGVATTRYS 375

Query: 1263 LTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI-W 1321
            + GL  +  Y  +VLA   IG G PS   +  RT +  P  P   +   + + S  L+ W
Sbjct: 376  IGGLSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQARMLSASTMLVQW 434

Query: 1322 QPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRK 1381
            +PP  PNG++  Y++ +  ++     A  +    +    T   L P   Y  R+ A T  
Sbjct: 435  EPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAV 494

Query: 1382 GWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRE 1441
            G G  +  + V T++    QP       + D R   + LSW      L P +   I    
Sbjct: 495  GDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR---IQLSW------LLPPQERIIMYEL 545

Query: 1442 LPSGRWALHSASVSHNA-----SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTT 1496
            +    WA       H       SS+ ++ LKP T Y+F++ A +D+G   F+   E+ T 
Sbjct: 546  V---YWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602

Query: 1497 LQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRG 1556
             Q+ P   P  +      +T+V + W PP  D  NG++  + + Y  +  E      + G
Sbjct: 603  -QSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661

Query: 1557 INNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEV 1616
            I+   ++W                    +L  L K   Y + +  +  VG GP S P  V
Sbjct: 662  ISREHSSW--------------------DLVGLEKWTEYRVWVRAHTDVGPGPESSPVLV 701

Query: 1617 FVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNL--TER 1674
               E VP+  PR V V    +T + V W+ P    Q+G I+GY++ +   + G       
Sbjct: 702  RTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPI 761

Query: 1675 VKTLFLAE-NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFS 1733
            ++ + LAE     +  LT  T Y V+VAA+   GDG RS P    T  A P  P+ +   
Sbjct: 762  IQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMM--- 818

Query: 1734 ELTTTSVN---VSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKD 1790
             ++TT++N   + W  P+   G L GYRL Y  C   +  ++  T+D  G       V  
Sbjct: 819  -ISTTAMNTALLQWHPPKELPGELLGYRLQY--CRADE--ARPNTIDF-GKDDQHFTVTG 872

Query: 1791 LAEGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDP 1849
            L +G TY FR+ AK     G E E  + T     +  P  + +    +S   + W   DP
Sbjct: 873  LHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW---DP 929

Query: 1850 -----GKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVN 1904
                   G I  Y +  R  +        +++    +   F++  LKP  +YD +V A  
Sbjct: 930  PVLAERNGRIISYTVVFRDINSQ------QELQNITTDTRFTLTGLKPDTTYDIKVRAWT 983

Query: 1905 DYGFG--TPSSPSQSVPAQK 1922
              G G  +PS  S+++P ++
Sbjct: 984  SKGSGPLSPSIQSRTMPVEQ 1003



 Score =  197 bits (502), Expect = 7e-50
 Identities = 264/1045 (25%), Positives = 424/1045 (40%), Gaps = 96/1045 (9%)

Query: 141  PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAP-----DAGRYYVQAVNDKNGDNKT 195
            P+P++TW + G+K+       I  ++    +  + P     D   Y   A N   G+  T
Sbjct: 60   PKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL-GEINT 118

Query: 196  SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDG 255
            S  +++  E       P  P+I + P+   VV      T+ C A   P     I W KD 
Sbjct: 119  SAKLSVLEEE---QLPPGFPSIDMGPQ-LKVVEKARTATMLCAAGGNP--DPEISWFKDF 172

Query: 256  VLLSGGISD------HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQ 309
            + +    S+       +  L I +   SD G YEC A   + +  S     Y+ V     
Sbjct: 173  LPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAP 232

Query: 310  FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG--LQI 367
                P           V++ C A G P P + W   A     E+LT+  +   G   L++
Sbjct: 233  RFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGA-----EELTKEDEMPVGRNVLEL 287

Query: 368  SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVLACET 425
            S +V   +  + C A ++ G ++ +  + V +    + + P+D  V +    SV L  + 
Sbjct: 288  SNVV--RSANYTCVAISSLGMIEATAQVTVKA----LPKPPIDLVVTETTATSVTLTWD- 340

Query: 426  SGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG-------TYTCLAT 478
            SG   P   +  G +  A+G+     F  ++     ++ T  S  G        +  LA 
Sbjct: 341  SGNSEPVTYY--GIQYRAAGTE--GPFQEVDG----VATTRYSIGGLSPFSEYAFRVLAV 392

Query: 479  NSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL 538
            NS G    S    V ART    P    S  +  QA M+   T    V      E +G   
Sbjct: 393  NSIGRGPPSE--AVRARTGEQAP---SSPPRRVQARMLSAST--MLVQWEPPEEPNGLVR 445

Query: 539  GTESH--PRIRLDRNGSLHISQTWSG---DIG------TYTCRVI--SAGGNDSRSAHLR 585
            G   +  P  R   N + H   T +G    +G      TY+ RV+  +A G+   S  ++
Sbjct: 446  GYRVYYTPDSRRPPN-AWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQ 504

Query: 586  VRQLPHAPEHPVATLSTVER-RAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVD 644
            V+     P  P    + VE    I L+W  P      +   +   +E+      +  + D
Sbjct: 505  VKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKV--TFD 562

Query: 645  PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTN 704
            P  +S T++ L P   Y+F+L A +D+G G F+   E     +  P+APPQ V+     +
Sbjct: 563  P-TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIE-ARTAQSTPSAPPQKVMCVSMGS 620

Query: 705  QSIMIQWQPPPESHQNGILKGYIIRY-CLAGLPVGYQFKNITDADVNNLLLEDLIIWTNY 763
             ++ + W PPP   +NG++  Y + Y  + G   G    +    + ++  L  L  WT Y
Sbjct: 621  TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680

Query: 764  EIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGI 823
             + V A+   G G  SS V   T + VP+ PP  V  E  NST +   W  P P   +G 
Sbjct: 681  RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740

Query: 824  NQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRS 883
             +GY++     E  E   +   +           +SGL   T Y  +V  +TT GDG RS
Sbjct: 741  IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYSVTVAAYTTKGDGARS 800

Query: 884  TPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVT 943
             P++V T   VPG    +  +  ++T+L + W  P E  G L GYR+ +   +       
Sbjct: 801  KPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYCRADEARPNTI 859

Query: 944  HYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELP-GPPTNLGIS 1002
             +  +    + VTGL   TTY   +AA    G G+     I +  P +LP G P NL ++
Sbjct: 860  DFGKD-DQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRT--PEDLPSGFPQNLHVT 916

Query: 1003 NIGPRSVTLQFRPGYDGKTS---ISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVP 1059
             +   +  L + P    + +   IS  +V   +    E         L N        + 
Sbjct: 917  GLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQE---------LQNITTDTRFTLT 967

Query: 1060 DLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMP 1119
             L P T Y  ++R     G+ P S PS + +T+      A  N  +  A +TS+ L W  
Sbjct: 968  GLKPDTTYDIKVRAWTSKGSGPLS-PSIQSRTMPVEQVFA-KNFRVAAAMKTSVLLSW-E 1024

Query: 1120 LPEMEYNGNPESVGYKIKYSRSDGH 1144
            +P+   +  P  + Y  +    DGH
Sbjct: 1025 VPDSYKSAVPFKILYNGQSVEVDGH 1049



 Score =  187 bits (474), Expect = 1e-46
 Identities = 207/827 (25%), Positives = 345/827 (41%), Gaps = 97/827 (11%)

Query: 992  LPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
            LP PP +L ++     SVTL +  G     +       A  G  G  +E        +  
Sbjct: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA-AGTEGPFQE-------VDGV 369

Query: 1052 DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111
                  +  L+PF+ Y+FR+  VN +G  PPS+  R  +T +  P   P  V  R  S +
Sbjct: 370  ATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRA-RTGEQAPSSPPRRVQARMLSAS 428

Query: 1112 SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEY 1171
            ++ ++W P PE E NG     GY++ Y+          H          T+  L     Y
Sbjct: 429  TMLVQWEP-PE-EPNGLVR--GYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484

Query: 1172 RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGL 1231
             ++V AF A+G GP S T+  +T++ VP+  P +  A   + + + + W  +P  +R   
Sbjct: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWL-LPPQER--- 539

Query: 1232 VLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP 1290
            ++ Y+++Y   +D D Q +   V  + + S  L  L    LY  Q+ A + +G G  + P
Sbjct: 540  IIMYELVYWAAEDEDQQHK---VTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT-P 595

Query: 1291 PILERTLDDVPG-PPMGILFPEVRTTSVRLIWQPPAAP--NGIILAYQITHR-LNTTTAN 1346
             I  RT    P  PP  ++   + +T+VR+ W PP A   NG+I  Y + +  ++     
Sbjct: 596  TIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRG 655

Query: 1347 TATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRP 1406
               V+ ++     +   GL+  + Y   + A T  G G  +  ++V T++ D P  P R 
Sbjct: 656  RHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDE-DVPSGPPRK 714

Query: 1407 MVQQEDVRARSVLLSW-------EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNAS 1459
             V+ E + + +V + W       + G      V Y  ++  E P G   +    ++  A 
Sbjct: 715  -VEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGE-PRGLPIIQDVMLAE-AQ 771

Query: 1460 SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVL 1519
               +  L P T+Y   V A    GD   S+  + +TT  A P     ++S T   T   L
Sbjct: 772  ETTISGLTPETTYSVTVAAYTTKGDGARSKP-KIVTTTGAVPGRPTMMISTTAMNTA--L 828

Query: 1520 IRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRP 1579
            ++W PP E  + G LLG+R++Y                                 + +RP
Sbjct: 829  LQWHPPKE--LPGELLGYRLQY------------------------------CRADEARP 856

Query: 1580 SLTQYELDN-------LNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVV 1632
            +   +  D+       L+K   Y  R++  N  G G     +E+   E +P+  P+N+ V
Sbjct: 857  NTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE-KEIRTPEDLPSGFPQNLHV 915

Query: 1633 HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG 1692
             G T +  ++ W+PP L  +NG I  Y + F +       + + T    +    L  L  
Sbjct: 916  TGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITT----DTRFTLTGLKP 971

Query: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
             T Y + V A+ + G GP S   Q +T         + + +    TSV +SWE P     
Sbjct: 972  DTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPD---- 1027

Query: 1753 ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 1799
                    Y+   P   +    +V+V G+S   L + DL     Y F
Sbjct: 1028 -------SYKSAVPFKILYNGQSVEVDGHSMRKL-IADLQPNTEYSF 1066



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 61/221 (27%), Positives = 85/221 (38%), Gaps = 32/221 (14%)

Query: 1719 TQQAAPSAPSSVKFSELTTTSVNVSWEA----PQFPNGILEGYRLVYEPCSPVDGVSKIV 1774
            T +A P  P  +  +E T TSV ++W++    P    GI         P   VDGV+   
Sbjct: 314  TVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVA-TT 372

Query: 1775 TVDVKGNSPLWLKVKDLAEGVTYRFRIRA-KTFTYGPEIEANVTTGPGEGAPGPPGVPII 1833
               + G SP             Y FR+ A  +   GP  EA V    GE AP  P   + 
Sbjct: 373  RYSIGGLSPF----------SEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQ 421

Query: 1834 VRYSSA--IAIHWSSGDPGKGPITRYVIEARPSDE---GLWDILIKDIPKEVSSYTFSMD 1888
             R  SA  + + W   +   G +  Y +   P        W     D     +    ++ 
Sbjct: 422  ARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTD-----AGLLTTVG 476

Query: 1889 ILKPGVSYDFRVIAVNDYGFGTPS-----SPSQSVPAQKAN 1924
             L PG++Y  RV+A    G G PS        Q VPAQ A+
Sbjct: 477  SLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD 517



 Score = 38.9 bits (89), Expect = 0.056
 Identities = 35/116 (30%), Positives = 58/116 (50%), Gaps = 14/116 (12%)

Query: 1811 EIEANVTTGPGEGAPGPPGVPIIVRYSSA--IAIHWSSGDPGKGPITRYVIEARPSD-EG 1867
            E  A VT    +  P PP + ++V  ++A  + + W SG+    P+T Y I+ R +  EG
Sbjct: 308  EATAQVTV---KALPKPP-IDLVVTETTATSVTLTWDSGN--SEPVTYYGIQYRAAGTEG 361

Query: 1868 LWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKA 1923
             +  +       V++  +S+  L P   Y FRV+AVN  G G PS   ++   ++A
Sbjct: 362  PFQEV-----DGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412


>gi|81158226 neuronal cell adhesion molecule isoform A precursor [Homo
            sapiens]
          Length = 1304

 Score =  264 bits (674), Expect = 8e-70
 Identities = 257/1067 (24%), Positives = 439/1067 (41%), Gaps = 90/1067 (8%)

Query: 44   LVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLD---------------RTHAGF 88
            +V+ C A+G  P  F W  N    T F ++   ++T                   T+ G 
Sbjct: 64   IVIQCEAKGKPPPSFSWTRNG---THFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGV 120

Query: 89   YRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVS--HGEAAVIRAPRIASFPQPQVT 146
            Y+C  RN  GA +     V+ +    + + EK + ++   G++ V+        P P + 
Sbjct: 121  YQCTARNERGAAVSNNIVVRPSRSPLWTK-EKLEPITLQSGQSLVLPCRPPIGLPPPIIF 179

Query: 147  WFRDG-RKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDN-KTSQPITLTVE 204
            W  +  +++P S R++  L   L   + +  D    Y+      +    +  QPI++ V 
Sbjct: 180  WMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVI 239

Query: 205  NVGGPADPIA------------------PTIIIPPKNTSVVAGT--SEVTLECVANARPL 244
            +V    D IA                  PT + P  N S       + ++LEC+A   P 
Sbjct: 240  SVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPT 299

Query: 245  IKLHIIW-KKDGVLLSGGISDHN--RRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 301
              ++  W K+DG+L        N  + L I + + +D+G Y+C A    +++ ++     
Sbjct: 300  PIIY--WAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIA---KNALGAIHHTIS 354

Query: 302  LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 361
            + V   P ++  P+  + +  E    I C+A G P P I+W  +   +E+      R+ +
Sbjct: 355  VRVKAAPYWITAPQNLVLSPGEDGTLI-CRANGNPKPRISWLTNGVPIEIAPDDPSRKID 413

Query: 362  DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVV 420
               +  S +    + ++QC A N  G +  + ++ V +  P I T       VI     +
Sbjct: 414  GDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPAL 473

Query: 421  LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480
            L C   G+P P I W KG +     ++    +   E+G+L I        GTYTC+A N 
Sbjct: 474  LDCAFFGSPLPTIEWFKGAK---GSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNK 530

Query: 481  RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540
             G+ +    L +   T I K P+   V +G+  S  C V HD  +++  +W KD   L +
Sbjct: 531  LGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPS 590

Query: 541  ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPE------ 594
            +   R  +D++  L ++     D GTYTC   +   + S SA L V      P       
Sbjct: 591  DE--RFTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVAPTPTPAPVYDVP 647

Query: 595  HPVATLSTVER--RAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTV 652
            +P   L   ++  +++ L+WT   D NSP+ ++I+E  +      +     +   T  T 
Sbjct: 648  NPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTA 707

Query: 653  K-GLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQW 711
            +  L P  +Y FR+ AVN +GK   S+ +E+       P   P  V   G    +++I W
Sbjct: 708  QLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITW 767

Query: 712  QPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYN 771
            +P      NG   G   +          ++ ++  A+V+  ++     +  Y I+V A N
Sbjct: 768  KPLNGFESNG--PGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALN 825

Query: 772  SAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIA 831
              G     + V   + + +P V PGNV     NST     W+    + I G  QGY++  
Sbjct: 826  DMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYY 885

Query: 832  WEPEQEEEVTMVTARPN---FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLV 888
            W+ +   +            FQ S   G + GL+ F+ Y  +V      G+GP S  ++ 
Sbjct: 886  WKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVF 945

Query: 889  RTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTN---TRVTHY 945
             T E VP     L        SL + W  P   NGILT Y + ++  N T+     V   
Sbjct: 946  NTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLK 1005

Query: 946  LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG-QVSASTISSGVPPELPGPPTNLG-ISN 1003
            +P     + +  L   T Y     A TS G G Q++   +++     +  P    G +  
Sbjct: 1006 IPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTTVDEAGILPPDVGAGKVQA 1065

Query: 1004 IGPRSVTLQFRPG---------YDGKTSISRWLVEAQVGVVGEGEEW 1041
            + PR   L              Y+G   ++ ++   + GV G  EEW
Sbjct: 1066 VNPRISNLTAAAAETYANISWEYEGPEHVNFYV---EYGVAGSKEEW 1109



 Score =  203 bits (516), Expect = 2e-51
 Identities = 166/591 (28%), Positives = 259/591 (43%), Gaps = 59/591 (9%)

Query: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTREL--PSGRWALHSASVS 1455
            D P PP    ++  D   +SV LSW PG D  SP+  + I+  +     G W  H   VS
Sbjct: 645  DVPNPPFD--LELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWH-HQTEVS 701

Query: 1456 HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTT 1515
               ++  + +L P+ +Y FRV A N IG S  SE SE   T  + PD+ PT +       
Sbjct: 702  GTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEP 760

Query: 1516 TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
             +++I W+P    + NG  L +++ +R+               +    W  +     + N
Sbjct: 761  DNLVITWKPLNGFESNGPGLQYKVSWRQ--------------KDGDDEWTSVV----VAN 802

Query: 1576 LSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGA 1635
            +S+     Y +        Y I++   N +G  P         GE +P  AP NV V+  
Sbjct: 803  VSK-----YIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVV 857

Query: 1636 TATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQ------RGNLTERVKTLFLAENSVKLKN 1689
             +T  +V W+P PL S  G +QGY+IY+W+ Q      R ++ +++ T   ++    L  
Sbjct: 858  NSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPG 917

Query: 1690 LTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQF 1749
            L  ++ Y ++V   N  G+GP S      T +  PSAPSS+K    T  S+ + W+ P  
Sbjct: 918  LEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSH 977

Query: 1750 PNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT-Y 1808
            PNGIL  Y L Y+P +    +  +V + +  N   W  +K+L     Y+F   A+T    
Sbjct: 978  PNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRW-TLKNLNFSTRYKFYFYAQTSAGS 1036

Query: 1809 GPEIEANVTTGPGEGAPGPPGV---------PIIVRYSSAIA-----IHWSSGDPGKGPI 1854
            G +I     T   E    PP V         P I   ++A A     I W    P    +
Sbjct: 1037 GSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEH--V 1094

Query: 1855 TRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSP 1914
              YV       +  W    K+I     S+ F +  L PG +Y  RV AV D GF +    
Sbjct: 1095 NFYVEYGVAGSKEEWR---KEIVNGSRSF-FGLKGLMPGTAYKVRVGAVGDSGFVSSEDV 1150

Query: 1915 SQSVPAQKAN--PFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKK 1963
             ++ PA  +       + WF+ ++  V L+ ++LL+   I R +  KY  K
Sbjct: 1151 FETGPAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGKYPVK 1201



 Score =  166 bits (420), Expect = 2e-40
 Identities = 147/545 (26%), Positives = 232/545 (42%), Gaps = 43/545 (7%)

Query: 979  VSASTISSGVPP--------ELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEA 1030
            VSAS + S V P        ++P PP +L +++   +SV L + PG D  + I+++++E 
Sbjct: 625  VSASAVLSVVAPTPTPAPVYDVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEY 684

Query: 1031 QVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQ 1090
            +  +   G    L H  +     ++     L+P+  YSFR+  VN +G S PS+ S +  
Sbjct: 685  EDAMHKPG----LWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYL 740

Query: 1091 TLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSH 1150
            T  + PD  P  V    +   +L + W PL   E NG    + YK+ + + DG  +  S 
Sbjct: 741  TKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNG--PGLQYKVSWRQKDGDDEWTSV 798

Query: 1151 VVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALA 1210
            VV +  +  Y +     +  Y ++VQA N +G  P    V+G + E +P   P NV    
Sbjct: 799  VVANVSK--YIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNV 856

Query: 1211 TTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVE------GNSSRSAQLT 1264
              S+   V W  VP     G + GY++ Y +  S ++     +E        S     L 
Sbjct: 857  VNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLP 916

Query: 1265 GLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPP 1324
            GL  +  Y + V      G+G P+ P  +  T + VP  P  +        S+ L W PP
Sbjct: 917  GLEPFSHYTLNVRVVNGKGEG-PASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPP 975

Query: 1325 AAPNGIILAYQITHR-LNTTTANTATVEVLAPSAR-QYTATGLKPESVYLFRITAQTRKG 1382
            + PNGI+  Y + ++ +N+T      V++  P+ + ++T   L   + Y F   AQT  G
Sbjct: 976  SHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAG 1035

Query: 1383 WGEAAEALVVTTEKRDRPQPPS---------RPMVQQEDVRARSVL--LSWEPGSDGLSP 1431
             G       VTT       PP           P +      A      +SWE   +G   
Sbjct: 1036 SGSQITEEAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWE--YEGPEH 1093

Query: 1432 VRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEES 1491
            V +Y           W      V+ + S F +  L P T+YK RV A   +GDS F    
Sbjct: 1094 VNFYVEYGVAGSKEEW--RKEIVNGSRSFFGLKGLMPGTAYKVRVGA---VGDSGFVSSE 1148

Query: 1492 ESLTT 1496
            +   T
Sbjct: 1149 DVFET 1153



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 101/386 (26%), Positives = 151/386 (39%), Gaps = 40/386 (10%)

Query: 39  LEGNRLVLTCMAEG------SWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHAGFYRCI 92
           L GN L L C+AEG       W  E   L  NR + K + E    I  +    +G Y+CI
Sbjct: 283 LRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK-NFEKTLQIIHVSEADSGNYQCI 341

Query: 93  VRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR 152
            +N +GA +     V+V     +    ++  +S GE   +   R    P+P+++W  +G 
Sbjct: 342 AKNALGA-IHHTISVRVKAAPYWITAPQNLVLSPGEDGTLIC-RANGNPKPRISWLTNGV 399

Query: 153 KI-----PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVG 207
            I      PS +I    +   +I S V   +      AV   N  N+    +     NV 
Sbjct: 400 PIEIAPDDPSRKI----DGDTIIFSNVQERS-----SAVYQCNASNEYGYLLANAFVNV- 449

Query: 208 GPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGI--SDH 265
             A+P  P I+ P      V       L+C     PL  +       G  L   I     
Sbjct: 450 -LAEP--PRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHE 506

Query: 266 NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKV 325
           N  L IP       G Y C A  +     + V   +L + +P   VK+PE +   +   +
Sbjct: 507 NGTLEIPVAQKDSTGTYTCVARNKLGMAKNEV---HLEIKDPTWIVKQPE-YAVVQRGSM 562

Query: 326 VDIPCQAKGVPPPSIT--WYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFAR 383
           V   C+ K     S+T  W KD    E+    RF    D  L ++ +  DD+G + C A 
Sbjct: 563 VSFECKVKHDHTLSLTVLWLKDNR--ELPSDERFTVDKD-HLVVADVSDDDSGTYTCVAN 619

Query: 384 NAAGEVQTSTYLAVTSIAPNITRGPL 409
                V  S  L+V  +AP  T  P+
Sbjct: 620 TTLDSVSASAVLSV--VAPTPTPAPV 643



 Score = 61.6 bits (148), Expect = 8e-09
 Identities = 41/140 (29%), Positives = 70/140 (50%), Gaps = 9/140 (6%)

Query: 304 VLEPPQFVKE-PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 362
           +++PP   ++ P+ +I    E +V I C+AKG PPPS +W ++    +++K      +  
Sbjct: 42  LVQPPTITQQSPKDYIIDPRENIV-IQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKPG 100

Query: 363 GGLQISGLVPDD-----TGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS-TVIDG 416
            G  I  ++ +       G++QC ARN  G   ++  +   S +P  T+  L+  T+  G
Sbjct: 101 TGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSG 160

Query: 417 MSVVLACETS-GAPRPAITW 435
            S+VL C    G P P I W
Sbjct: 161 QSLVLPCRPPIGLPPPIIFW 180



 Score = 35.4 bits (80), Expect = 0.61
 Identities = 37/167 (22%), Positives = 65/167 (38%), Gaps = 6/167 (3%)

Query: 402 PNITR-GPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSL 460
           P IT+  P D  +    ++V+ CE  G P P+ +W +           L    P  +G+L
Sbjct: 46  PTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP-GTGTL 104

Query: 461 LISPTHISDA----GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 516
           +I+      A    G Y C A N RG   ++  +V  +R+ +    + + +   +  S+V
Sbjct: 105 IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 164

Query: 517 CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGD 563
                   +    I+  D +        R+    NG L+ S     D
Sbjct: 165 LPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPED 211


>gi|81158224 neuronal cell adhesion molecule isoform B precursor [Homo
            sapiens]
          Length = 1183

 Score =  264 bits (674), Expect = 8e-70
 Identities = 244/994 (24%), Positives = 417/994 (41%), Gaps = 71/994 (7%)

Query: 44   LVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLD---------------RTHAGF 88
            +V+ C A+G  P  F W  N    T F ++   ++T                   T+ G 
Sbjct: 58   IVIQCEAKGKPPPSFSWTRNG---THFDIDKDPLVTMKPGTGTLIINIMSEGKAETYEGV 114

Query: 89   YRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVS--HGEAAVIRAPRIASFPQPQVT 146
            Y+C  RN  GA +     V+ +    + + EK + ++   G++ V+        P P + 
Sbjct: 115  YQCTARNERGAAVSNNIVVRPSRSPLWTK-EKLEPITLQSGQSLVLPCRPPIGLPPPIIF 173

Query: 147  WFRDG-RKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDN-KTSQPITLTVE 204
            W  +  +++P S R++  L   L   + +  D    Y+      +    +  QPI++ V 
Sbjct: 174  WMDNSFQRLPQSERVSQGLNGDLYFSNVLPEDTREDYICYARFNHTQTIQQKQPISVKVI 233

Query: 205  NVGGPADPIA------------------PTIIIPPKNTSVVAGT--SEVTLECVANARPL 244
            +V    D IA                  PT + P  N S       + ++LEC+A   P 
Sbjct: 234  SVDELNDTIAANLSDTEFYGAKSSRERPPTFLTPEGNASNKEELRGNVLSLECIAEGLPT 293

Query: 245  IKLHIIW-KKDGVLLSGGISDHN--RRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAY 301
              ++  W K+DG+L        N  + L I + + +D+G Y+C A    +++ ++     
Sbjct: 294  PIIY--WAKEDGMLPKNRTVYKNFEKTLQIIHVSEADSGNYQCIA---KNALGAIHHTIS 348

Query: 302  LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRN 361
            + V   P ++  P+  + +  E    I C+A G P P I+W  +   +E+      R+ +
Sbjct: 349  VRVKAAPYWITAPQNLVLSPGEDGTLI-CRANGNPKPRISWLTNGVPIEIAPDDPSRKID 407

Query: 362  DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVIDGMSVV 420
               +  S +    + ++QC A N  G +  + ++ V +  P I T       VI     +
Sbjct: 408  GDTIIFSNVQERSSAVYQCNASNEYGYLLANAFVNVLAEPPRILTPANTLYQVIANRPAL 467

Query: 421  LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480
            L C   G+P P I W KG +     ++    +   E+G+L I        GTYTC+A N 
Sbjct: 468  LDCAFFGSPLPTIEWFKGAK---GSALHEDIYVLHENGTLEIPVAQKDSTGTYTCVARNK 524

Query: 481  RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540
             G+ +    L +   T I K P+   V +G+  S  C V HD  +++  +W KD   L +
Sbjct: 525  LGMAKNEVHLEIKDPTWIVKQPEYAVVQRGSMVSFECKVKHDHTLSLTVLWLKDNRELPS 584

Query: 541  ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATL 600
            +   R  +D++  L ++     D GTYTC   +   + S SA L V  +P+ P      L
Sbjct: 585  DE--RFTVDKD-HLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVDVPNPPFD--LEL 639

Query: 601  STVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVK-GLVPAR 659
            +    +++ L+WT   D NSP+ ++I+E  +      +     +   T  T +  L P  
Sbjct: 640  TDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQLKLSPYV 699

Query: 660  SYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQ 719
            +Y FR+ AVN +GK   S+ +E+       P   P  V   G    +++I W+P      
Sbjct: 700  NYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFES 759

Query: 720  NGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS 779
            NG   G   +          ++ ++  A+V+  ++     +  Y I+V A N  G     
Sbjct: 760  NG--PGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGFAPEP 817

Query: 780  SKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEE 839
            + V   + + +P V PGNV     NST     W+    + I G  QGY++  W+ +   +
Sbjct: 818  AVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSK 877

Query: 840  VTMVTARPN---FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPG 896
                        FQ S   G + GL+ F+ Y  +V      G+GP S  ++  T E VP 
Sbjct: 878  RNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPS 937

Query: 897  PVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTN---TRVTHYLPNVTLEY 953
                L        SL + W  P   NGILT Y + ++  N T+     V   +P     +
Sbjct: 938  APSSLKIVNPTLDSLTLEWDPPSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRW 997

Query: 954  RVTGLTALTTYTIEVAAMTSKGQG-QVSASTISS 986
             +  L   T Y     A TS G G Q++   +++
Sbjct: 998  TLKNLNFSTRYKFYFYAQTSAGSGSQITEEAVTT 1031



 Score =  173 bits (438), Expect = 2e-42
 Identities = 121/416 (29%), Positives = 192/416 (46%), Gaps = 36/416 (8%)

Query: 1398 DRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTREL--PSGRWALHSASVS 1455
            D P PP    ++  D   +SV LSW PG D  SP+  + I+  +     G W  H   VS
Sbjct: 629  DVPNPPFD--LELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWH-HQTEVS 685

Query: 1456 HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTT 1515
               ++  + +L P+ +Y FRV A N IG S  SE SE   T  + PD+ PT +       
Sbjct: 686  GTQTTAQL-KLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEP 744

Query: 1516 TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
             +++I W+P    + NG  L +++ +R+               +    W  +     + N
Sbjct: 745  DNLVITWKPLNGFESNGPGLQYKVSWRQ--------------KDGDDEWTSVV----VAN 786

Query: 1576 LSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGA 1635
            +S+     Y +        Y I++   N +G  P         GE +P  AP NV V+  
Sbjct: 787  VSK-----YIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVV 841

Query: 1636 TATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQ------RGNLTERVKTLFLAENSVKLKN 1689
             +T  +V W+P PL S  G +QGY+IY+W+ Q      R ++ +++ T   ++    L  
Sbjct: 842  NSTLAEVHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPG 901

Query: 1690 LTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQF 1749
            L  ++ Y ++V   N  G+GP S      T +  PSAPSS+K    T  S+ + W+ P  
Sbjct: 902  LEPFSHYTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSH 961

Query: 1750 PNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT 1805
            PNGIL  Y L Y+P +    +  +V + +  N   W  +K+L     Y+F   A+T
Sbjct: 962  PNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRW-TLKNLNFSTRYKFYFYAQT 1016



 Score =  155 bits (392), Expect = 4e-37
 Identities = 119/424 (28%), Positives = 194/424 (45%), Gaps = 19/424 (4%)

Query: 979  VSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEG 1038
            VSAS + S V  ++P PP +L +++   +SV L + PG D  + I+++++E +  +   G
Sbjct: 619  VSASAVLSVV--DVPNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPG 676

Query: 1039 EEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDM 1098
                L H  +     ++     L+P+  YSFR+  VN +G S PS+ S +  T  + PD 
Sbjct: 677  ----LWHHQTEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDK 732

Query: 1099 APANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER 1158
             P  V    +   +L + W PL   E NG    + YK+ + + DG  +  S VV +  + 
Sbjct: 733  NPTAVEGLGSEPDNLVITWKPLNGFESNG--PGLQYKVSWRQKDGDDEWTSVVVANVSK- 789

Query: 1159 DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLV 1218
             Y +     +  Y ++VQA N +G  P    V+G + E +P   P NV      S+   V
Sbjct: 790  -YIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEV 848

Query: 1219 RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVE------GNSSRSAQLTGLGKYVLY 1272
             W  VP     G + GY++ Y +  S ++     +E        S     L GL  +  Y
Sbjct: 849  HWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHY 908

Query: 1273 EVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIIL 1332
             + V      G+G P+ P  +  T + VP  P  +        S+ L W PP+ PNGI+ 
Sbjct: 909  TLNVRVVNGKGEG-PASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILT 967

Query: 1333 AYQITHR-LNTTTANTATVEVLAPSAR-QYTATGLKPESVYLFRITAQTRKGWGEAAEAL 1390
             Y + ++ +N+T      V++  P+ + ++T   L   + Y F   AQT  G G      
Sbjct: 968  EYTLKYQPINSTHELGPLVDLKIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITEE 1027

Query: 1391 VVTT 1394
             VTT
Sbjct: 1028 AVTT 1031



 Score = 79.3 bits (194), Expect = 4e-14
 Identities = 101/484 (20%), Positives = 177/484 (36%), Gaps = 62/484 (12%)

Query: 1505 PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATW 1564
            P  L +T     SV + W P   D  N  +  F I Y + +++            PG  W
Sbjct: 634  PFDLELTDQLDKSVQLSWTPG--DDNNSPITKFIIEYEDAMHK------------PGL-W 678

Query: 1565 AELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAVP 1623
               T +   +  ++  L+ Y          Y  R+   N++G+  PS   ++     + P
Sbjct: 679  HHQTEVSGTQTTAQLKLSPYV--------NYSFRVMAVNSIGKSLPSEASEQYLTKASEP 730

Query: 1624 TAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAEN 1683
               P  V   G+    L +TW+P      NG    YK+  W  + G+  E    +    +
Sbjct: 731  DKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGLQYKVS-WRQKDGD-DEWTSVVVANVS 788

Query: 1684 SVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS-APSSVKFSELTTTSVNV 1742
               +     +  Y++ V A N  G  P      G + +  P  AP +V+ + + +T   V
Sbjct: 789  KYIVSGTPTFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEV 848

Query: 1743 SWEAPQFPN--GILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFR 1800
             W+     +  G L+GYR+ Y          K  +   +    +  K+       T+   
Sbjct: 849  HWDPVPLKSIRGHLQGYRIYYW---------KTQSSSKRNRRHIEKKILTFQGSKTHGML 899

Query: 1801 IRAKTFTYGPEIEANVTTGPGEGAPGPP-------GVP-------IIVRYSSAIAIHWSS 1846
               + F++   +   V  G GEG   P        GVP       I+     ++ + W  
Sbjct: 900  PGLEPFSHYT-LNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDP 958

Query: 1847 GDPGKGPITRYVIEARP--SDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVN 1904
                 G +T Y ++ +P  S   L  ++   IP   + +T     L     Y F   A  
Sbjct: 959  PSHPNGILTEYTLKYQPINSTHELGPLVDLKIPANKTRWTLKN--LNFSTRYKFYFYAQT 1016

Query: 1905 DYGFGTPSSPSQSVPAQKANPFYE-----EWWFLVVIALVGLIFILLLVFVLIIRGQSKK 1959
              G G+  +        +A    +     + WF+ ++  V L+ ++LL+   I R +  K
Sbjct: 1017 SAGSGSQITEEAVTTVDEAMASRQVDIATQGWFIGLMCAVALLILILLIVCFIRRNKGGK 1076

Query: 1960 YAKK 1963
            Y  K
Sbjct: 1077 YPVK 1080



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 99/380 (26%), Positives = 148/380 (38%), Gaps = 39/380 (10%)

Query: 39  LEGNRLVLTCMAEG------SWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHAGFYRCI 92
           L GN L L C+AEG       W  E   L  NR + K + E    I  +    +G Y+CI
Sbjct: 277 LRGNVLSLECIAEGLPTPIIYWAKEDGMLPKNRTVYK-NFEKTLQIIHVSEADSGNYQCI 335

Query: 93  VRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR 152
            +N +GA +     V+V     +    ++  +S GE   +   R    P+P+++W  +G 
Sbjct: 336 AKNALGA-IHHTISVRVKAAPYWITAPQNLVLSPGEDGTLIC-RANGNPKPRISWLTNGV 393

Query: 153 KI-----PPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVG 207
            I      PS +I    +   +I S V   +      AV   N  N+    +     NV 
Sbjct: 394 PIEIAPDDPSRKI----DGDTIIFSNVQERS-----SAVYQCNASNEYGYLLANAFVNV- 443

Query: 208 GPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGI--SDH 265
             A+P  P I+ P      V       L+C     PL  +       G  L   I     
Sbjct: 444 -LAEP--PRILTPANTLYQVIANRPALLDCAFFGSPLPTIEWFKGAKGSALHEDIYVLHE 500

Query: 266 NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKV 325
           N  L IP       G Y C A  +     + V   +L + +P   VK+PE +   +   +
Sbjct: 501 NGTLEIPVAQKDSTGTYTCVARNKLGMAKNEV---HLEIKDPTWIVKQPE-YAVVQRGSM 556

Query: 326 VDIPCQAKGVPPPSIT--WYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFAR 383
           V   C+ K     S+T  W KD    E+    RF    D  L ++ +  DD+G + C A 
Sbjct: 557 VSFECKVKHDHTLSLTVLWLKDNR--ELPSDERFTVDKD-HLVVADVSDDDSGTYTCVAN 613

Query: 384 NAAGEVQTSTYLAVTSIAPN 403
                V  S  L+V  + PN
Sbjct: 614 TTLDSVSASAVLSVVDV-PN 632



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 42/142 (29%), Positives = 71/142 (50%), Gaps = 9/142 (6%)

Query: 302 LSVLEPPQFVKE-PERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 360
           L +++PP   ++ P+ +I    E +V I C+AKG PPPS +W ++    +++K      +
Sbjct: 34  LDLVQPPTITQQSPKDYIIDPRENIV-IQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMK 92

Query: 361 NDGGLQISGLVPDD-----TGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS-TVI 414
              G  I  ++ +       G++QC ARN  G   ++  +   S +P  T+  L+  T+ 
Sbjct: 93  PGTGTLIINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQ 152

Query: 415 DGMSVVLACETS-GAPRPAITW 435
            G S+VL C    G P P I W
Sbjct: 153 SGQSLVLPCRPPIGLPPPIIFW 174



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 90/411 (21%), Positives = 153/411 (37%), Gaps = 56/411 (13%)

Query: 1218 VRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW--LVEGNSSRSAQLTGLGKYVLYEVQ 1275
            V+ S  P  D N  +  + + Y+  D+  +P  W    E + +++     L  YV Y  +
Sbjct: 647  VQLSWTPGDDNNSPITKFIIEYE--DAMHKPGLWHHQTEVSGTQTTAQLKLSPYVNYSFR 704

Query: 1276 VLAFTRIGDGSPSHPPILERTLDDVPGP-PMGILFPEVRTTSVRLIWQPPAA--PNGIIL 1332
            V+A   IG   PS       T    P   P  +        ++ + W+P      NG  L
Sbjct: 705  VMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWKPLNGFESNGPGL 764

Query: 1333 AYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392
             Y+++ R      +     V+  +  +Y  +G      YL ++ A    G+  A E  VV
Sbjct: 765  QYKVSWRQKD--GDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMGF--APEPAVV 820

Query: 1393 TTEKRDRPQPPSRPMVQQEDVRARSVL-----LSWEPGSDGLSPVR--------YYTIQT 1439
                 +       PMV   +VR   V      + W+P    L  +R        YY    
Sbjct: 821  MGHSGE-----DLPMVAPGNVRVNVVNSTLAEVHWDPVP--LKSIRGHLQGYRIYYWKTQ 873

Query: 1440 RELPSGRWALHSASVSHNASSF--IVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTL 1497
                  R  +    ++   S    ++  L+PF+ Y   V+  N  G+   S +     T 
Sbjct: 874  SSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSHYTLNVRVVNGKGEGPASPD-RVFNTP 932

Query: 1498 QAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGI 1557
            +  P  AP+ L +   T  S+ + W PP+    NGIL  + ++Y+               
Sbjct: 933  EGVPS-APSSLKIVNPTLDSLTLEWDPPSHP--NGILTEYTLKYQ--------------- 974

Query: 1558 NNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG 1608
              P  +  EL  +  ++  +    T++ L NLN   RY+       + G G
Sbjct: 975  --PINSTHELGPLVDLKIPANK--TRWTLKNLNFSTRYKFYFYAQTSAGSG 1021



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 32/105 (30%), Positives = 50/105 (47%), Gaps = 9/105 (8%)

Query: 1825 PGPP-GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPS--DEGLWDILIKDIPKEVS 1881
            P PP  + +  +   ++ + W+ GD    PIT+++IE   +    GLW         EVS
Sbjct: 631  PNPPFDLELTDQLDKSVQLSWTPGDDNNSPITKFIIEYEDAMHKPGLWHH-----QTEVS 685

Query: 1882 SYTFSMDI-LKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
                +  + L P V+Y FRV+AVN  G   PS  S+    + + P
Sbjct: 686  GTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEP 730



 Score = 35.4 bits (80), Expect = 0.61
 Identities = 37/167 (22%), Positives = 65/167 (38%), Gaps = 6/167 (3%)

Query: 402 PNITR-GPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSL 460
           P IT+  P D  +    ++V+ CE  G P P+ +W +           L    P  +G+L
Sbjct: 40  PTITQQSPKDYIIDPRENIVIQCEAKGKPPPSFSWTRNGTHFDIDKDPLVTMKP-GTGTL 98

Query: 461 LISPTHISDA----GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMV 516
           +I+      A    G Y C A N RG   ++  +V  +R+ +    + + +   +  S+V
Sbjct: 99  IINIMSEGKAETYEGVYQCTARNERGAAVSNNIVVRPSRSPLWTKEKLEPITLQSGQSLV 158

Query: 517 CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGD 563
                   +    I+  D +        R+    NG L+ S     D
Sbjct: 159 LPCRPPIGLPPPIIFWMDNSFQRLPQSERVSQGLNGDLYFSNVLPED 205


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score =  260 bits (665), Expect = 9e-69
 Identities = 290/1118 (25%), Positives = 466/1118 (41%), Gaps = 128/1118 (11%)

Query: 198  PITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVL 257
            P  + +  V G      P  I  P++ + ++G    +  C A   P  K  I W K G  
Sbjct: 16   PALVMLGLVAGAHGDSKPVFIKVPEDQTGLSG-GVASFVCQATGEP--KPRITWMKKGKK 72

Query: 258  LSGGISDHNRRLTIPNPTGS-----------DAGYYECEAVLRSSSVPSVVRGAYLSVLE 306
            +S   S     +   +  GS           D   YEC A   ++S+  +   A LSVLE
Sbjct: 73   VS---SQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTA---TNSLGEINTSAKLSVLE 126

Query: 307  ----PPQFVK---EPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLT-RFR 358
                PP F      P+  +  E  +   + C A G P P I+W+KD   V+      R +
Sbjct: 127  EEQLPPGFPSIDMGPQLKVV-EKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIK 185

Query: 359  QRNDGGLQISGLVPDDTGMFQCFARNAAG---EVQTSTYLAVTSIAPNITRGPLDSTVID 415
            Q   G LQI      D G ++C A N+AG       + Y+ V  +AP  +  P    V+ 
Sbjct: 186  QLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMP 245

Query: 416  GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTC 475
            G SV L C   GAP P + W  G         +L +   +  G  ++  +++  +  YTC
Sbjct: 246  GGSVNLTCVAVGAPMPYVKWMMGAE-------ELTKEDEMPVGRNVLELSNVVRSANYTC 298

Query: 476  LATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDG 535
            +A +S G+ EA+A + V A   + KPP D  V + T  S+           + Y   +  
Sbjct: 299  VAISSLGMIEATAQVTVKA---LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYR 355

Query: 536  ATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG--GNDSRSAHLRVRQLPHAP 593
            A  GTE  P   +D   +   S         Y  RV++    G    S  +R R    AP
Sbjct: 356  AA-GTEG-PFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAP 413

Query: 594  EHPVATLST--VERRAINLTWTKPFDGNSPLIRY-ILEMSENNAPWTVLLASVDPKATSV 650
              P   +    +    + + W  P + N  +  Y +    ++  P               
Sbjct: 414  SSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLT 473

Query: 651  TVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQ 710
            TV  L+P  +Y  R+ A   VG G  S  T +V   +  P A P +  A   ++  I + 
Sbjct: 474  TVGSLLPGITYSLRVLAFTAVGDGPPSP-TIQVKTQQGVP-AQPADFQAEVESDTRIQLS 531

Query: 711  WQPPPESHQNGILKGYIIRYCL---AGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEV 767
            W  PP+          II Y L   A      Q K +T    ++  LEDL   T Y  ++
Sbjct: 532  WLLPPQER--------IIMYELVYWAAEDEDQQHK-VTFDPTSSYTLEDLKPDTLYRFQL 582

Query: 768  AAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGI---- 823
            AA +  G+GV++  +   T Q  P+ PP  V   +  STT+R +W  P     NG+    
Sbjct: 583  AARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQY 642

Query: 824  NQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRS 883
            +  Y+ +  E      V  ++   +  D +      GL+K+TEY   V   T  G GP S
Sbjct: 643  SVAYEAVDGEDRGRHVVDGISREHSSWDLV------GLEKWTEYRVWVRAHTDVGPGPES 696

Query: 884  TPQLVRTHEDVP-GPVGHLSFSEILDTSLKVSWQ--EPGEKNGILTGYRISWEEYNRTNT 940
            +P LVRT EDVP GP   +    +  T++ V W+   P +++G + GY++++        
Sbjct: 697  SPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEP 756

Query: 941  RVTHYLPNVTL-------------EYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSG 987
            R    + +V L             E  ++GLT  TTY++ VAA T+KG G  S   I + 
Sbjct: 757  RGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVT- 815

Query: 988  VPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLV------EAQVGVVGEGEEW 1041
                +PG PT + IS     +  LQ+ P  +    +  + +      EA+   +  G+  
Sbjct: 816  TTGAVPGRPTMM-ISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGK-- 872

Query: 1042 LLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPA 1101
                      D +   V  L+  T Y FR+   N  G     +  ++I+T +  P   P 
Sbjct: 873  ----------DDQHFTVTGLHKGTTYIFRLAAKNRAGLG--EEFEKEIRTPEDLPSGFPQ 920

Query: 1102 NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYT 1161
            N+ +   + ++  L W P    E NG    + Y + + R     + L ++  D     +T
Sbjct: 921  NLHVTGLTTSTTELAWDPPVLAERNG--RIISYTVVF-RDINSQQELQNITTD---TRFT 974

Query: 1162 IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWS 1221
            +  L+  T Y ++V+A+ + GSGP S ++  RT   V      N    A   +S+L+ W 
Sbjct: 975  LTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM-PVEQVFAKNFRVAAAMKTSVLLSW- 1032

Query: 1222 EVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSR 1259
            EVP++ ++   + +K++Y  +  +       V+G+S R
Sbjct: 1033 EVPDSYKS--AVPFKILYNGQSVE-------VDGHSMR 1061



 Score =  204 bits (520), Expect = 6e-52
 Identities = 199/775 (25%), Positives = 326/775 (42%), Gaps = 70/775 (9%)

Query: 890  THEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNV 949
            T + +P P   L  +E   TS+ ++W     +   +T Y I +     T           
Sbjct: 314  TVKALPKPPIDLVVTETTATSVTLTWDSGNSEP--VTYYGIQYRAAG-TEGPFQEVDGVA 370

Query: 950  TLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSV 1009
            T  Y + GL+  + Y   V A+ S G+G  S +  +         PP  +    +   ++
Sbjct: 371  TTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTM 430

Query: 1010 TLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSF 1069
             +Q+ P  +    +  + V            W       N        V  L P   YS 
Sbjct: 431  LVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAW----HKHNTDAGLLTTVGSLLPGITYSL 486

Query: 1070 RMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNP 1129
            R+     VG  PPS P+ +++T Q  P   PA+      S+T + L W+ LP  E     
Sbjct: 487  RVLAFTAVGDGPPS-PTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWL-LPPQE----- 538

Query: 1130 ESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQT 1189
              + Y++ Y  ++   +   H V       YT+EDL+  T YR Q+ A + +G G ++ T
Sbjct: 539  RIIMYELVYWAAEDEDQ--QHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPT 596

Query: 1190 VVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPR 1249
            +  RT +S PS+ P  V  ++  S+++ V W   P   RNG++  Y V Y+  D + + R
Sbjct: 597  IEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGR 656

Query: 1250 FWLVEGNSSR--SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVP-GPPMG 1306
              +V+G S    S  L GL K+  Y V V A T +G G P   P+L RT +DVP GPP  
Sbjct: 657  H-VVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPG-PESSPVLVRTDEDVPSGPPRK 714

Query: 1307 ILFPEVRTTSVRLIWQ--PPAAPNGIILAYQITH-RLNTTTANTATV--EVLAPSAR--- 1358
            +    + +T+V + W+   P+  +G I  YQ+T+ RL         +  +V+   A+   
Sbjct: 715  VEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRP 774

Query: 1359 ------QYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQED 1412
                  + T +GL PE+ Y   + A T KG G  ++  +VTT        P RP +    
Sbjct: 775  EESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTT----TGAVPGRPTMMIST 830

Query: 1413 VRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSY 1472
                + LL W P  +    +  Y +Q       R   ++     +   F V  L   T+Y
Sbjct: 831  TAMNTALLQWHPPKELPGELLGYRLQYCRADEAR--PNTIDFGKDDQHFTVTGLHKGTTY 888

Query: 1473 KFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKING 1532
             FR+ A N  G  E  E  + + T +  P   P  L VT  TT++  + W PP   + NG
Sbjct: 889  IFRLAAKNRAGLGE--EFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNG 946

Query: 1533 ILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKH 1592
             ++ + + +R                       ++ S   ++N++    T++ L  L   
Sbjct: 947  RIISYTVVFR-----------------------DINSQQELQNITTD--TRFTLTGLKPD 981

Query: 1593 RRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPP 1647
              Y+I++  + + G GP SP  +      V     +N  V  A  T + ++WE P
Sbjct: 982  TTYDIKVRAWTSKGSGPLSPSIQSRT-MPVEQVFAKNFRVAAAMKTSVLLSWEVP 1035



 Score =  202 bits (513), Expect = 4e-51
 Identities = 192/749 (25%), Positives = 316/749 (42%), Gaps = 87/749 (11%)

Query: 1203 PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQ 1262
            P ++    TT++S+ + W    ++  +  V  Y + Y+   + T+  F  V+G ++    
Sbjct: 322  PIDLVVTETTATSVTLTW----DSGNSEPVTYYGIQYRA--AGTEGPFQEVDGVATTRYS 375

Query: 1263 LTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI-W 1321
            + GL  +  Y  +VLA   IG G PS   +  RT +  P  P   +   + + S  L+ W
Sbjct: 376  IGGLSPFSEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQARMLSASTMLVQW 434

Query: 1322 QPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRK 1381
            +PP  PNG++  Y++ +  ++     A  +    +    T   L P   Y  R+ A T  
Sbjct: 435  EPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAV 494

Query: 1382 GWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRE 1441
            G G  +  + V T++    QP       + D R   + LSW      L P +   I    
Sbjct: 495  GDGPPSPTIQVKTQQGVPAQPADFQAEVESDTR---IQLSW------LLPPQERIIMYEL 545

Query: 1442 LPSGRWALHSASVSHNA-----SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTT 1496
            +    WA       H       SS+ ++ LKP T Y+F++ A +D+G   F+   E+ T 
Sbjct: 546  V---YWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTA 602

Query: 1497 LQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRG 1556
             Q+ P   P  +      +T+V + W PP  D  NG++  + + Y  +  E      + G
Sbjct: 603  -QSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDG 661

Query: 1557 INNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEV 1616
            I+   ++W                    +L  L K   Y + +  +  VG GP S P  V
Sbjct: 662  ISREHSSW--------------------DLVGLEKWTEYRVWVRAHTDVGPGPESSPVLV 701

Query: 1617 FVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNL--TER 1674
               E VP+  PR V V    +T + V W+ P    Q+G I+GY++ +   + G       
Sbjct: 702  RTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPI 761

Query: 1675 VKTLFLAE----------NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAP 1724
            ++ + LAE              +  LT  T Y V+VAA+   GDG RS P    T  A P
Sbjct: 762  IQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVP 821

Query: 1725 SAPSSVKFSELTTTSVN---VSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGN 1781
              P+ +    ++TT++N   + W  P+   G L GYRL Y  C   +  ++  T+D  G 
Sbjct: 822  GRPTMM----ISTTAMNTALLQWHPPKELPGELLGYRLQY--CRADE--ARPNTIDF-GK 872

Query: 1782 SPLWLKVKDLAEGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAI 1840
                  V  L +G TY FR+ AK     G E E  + T     +  P  + +    +S  
Sbjct: 873  DDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTT 932

Query: 1841 AIHWSSGDP-----GKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVS 1895
             + W   DP       G I  Y +  R  +        +++    +   F++  LKP  +
Sbjct: 933  ELAW---DPPVLAERNGRIISYTVVFRDINSQ------QELQNITTDTRFTLTGLKPDTT 983

Query: 1896 YDFRVIAVNDYGFG--TPSSPSQSVPAQK 1922
            YD +V A    G G  +PS  S+++P ++
Sbjct: 984  YDIKVRAWTSKGSGPLSPSIQSRTMPVEQ 1012



 Score =  196 bits (498), Expect = 2e-49
 Identities = 268/1055 (25%), Positives = 429/1055 (40%), Gaps = 107/1055 (10%)

Query: 141  PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAP-----DAGRYYVQAVNDKNGDNKT 195
            P+P++TW + G+K+       I  ++    +  + P     D   Y   A N   G+  T
Sbjct: 60   PKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSL-GEINT 118

Query: 196  SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDG 255
            S  +++  E       P  P+I + P+   VV      T+ C A   P     I W KD 
Sbjct: 119  SAKLSVLEEE---QLPPGFPSIDMGPQ-LKVVEKARTATMLCAAGGNP--DPEISWFKDF 172

Query: 256  VLLSGGISD------HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQ 309
            + +    S+       +  L I +   SD G YEC A   + +  S     Y+ V     
Sbjct: 173  LPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAP 232

Query: 310  FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG--LQI 367
                P           V++ C A G P P + W   A     E+LT+  +   G   L++
Sbjct: 233  RFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGA-----EELTKEDEMPVGRNVLEL 287

Query: 368  SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID--GMSVVLACET 425
            S +V   +  + C A ++ G ++ +  + V +    + + P+D  V +    SV L  + 
Sbjct: 288  SNVV--RSANYTCVAISSLGMIEATAQVTVKA----LPKPPIDLVVTETTATSVTLTWD- 340

Query: 426  SGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG-------TYTCLAT 478
            SG   P   +  G +  A+G+     F  ++     ++ T  S  G        +  LA 
Sbjct: 341  SGNSEPVTYY--GIQYRAAGTE--GPFQEVDG----VATTRYSIGGLSPFSEYAFRVLAV 392

Query: 479  NSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL 538
            NS G    S    V ART    P    S  +  QA M+   T    V      E +G   
Sbjct: 393  NSIGRGPPSE--AVRARTGEQAP---SSPPRRVQARMLSAST--MLVQWEPPEEPNGLVR 445

Query: 539  GTESH--PRIRLDRNGSLHISQTWSG---DIG------TYTCRVI--SAGGNDSRSAHLR 585
            G   +  P  R   N + H   T +G    +G      TY+ RV+  +A G+   S  ++
Sbjct: 446  GYRVYYTPDSRRPPN-AWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQ 504

Query: 586  VRQLPHAPEHPVATLSTVER-RAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVD 644
            V+     P  P    + VE    I L+W  P      +   +   +E+      +  + D
Sbjct: 505  VKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKV--TFD 562

Query: 645  PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTN 704
            P  +S T++ L P   Y+F+L A +D+G G F+   E     +  P+APPQ V+     +
Sbjct: 563  P-TSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIE-ARTAQSTPSAPPQKVMCVSMGS 620

Query: 705  QSIMIQWQPPPESHQNGILKGYIIRY-CLAGLPVGYQFKNITDADVNNLLLEDLIIWTNY 763
             ++ + W PPP   +NG++  Y + Y  + G   G    +    + ++  L  L  WT Y
Sbjct: 621  TTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEY 680

Query: 764  EIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGI 823
             + V A+   G G  SS V   T + VP+ PP  V  E  NST +   W  P P   +G 
Sbjct: 681  RVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQ 740

Query: 824  NQGYKLIAWEPEQEE--------EVTMVTA--RPNFQDSIHVGFVSGLKKFTEYFTSVLC 873
             +GY++     E  E        +V +  A  RP   +      +SGL   T Y  +V  
Sbjct: 741  IRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYET-TISGLTPETTYSVTVAA 799

Query: 874  FTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWE 933
            +TT GDG RS P++V T   VPG    +  +  ++T+L + W  P E  G L GYR+ + 
Sbjct: 800  YTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTAL-LQWHPPKELPGELLGYRLQYC 858

Query: 934  EYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELP 993
              +        +  +    + VTGL   TTY   +AA    G G+     I +  P +LP
Sbjct: 859  RADEARPNTIDFGKD-DQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRT--PEDLP 915

Query: 994  -GPPTNLGISNIGPRSVTLQFRPGYDGKTS---ISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
             G P NL ++ +   +  L + P    + +   IS  +V   +    E         L N
Sbjct: 916  SGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQE---------LQN 966

Query: 1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
                    +  L P T Y  ++R     G+ P S PS + +T+      A  N  +  A 
Sbjct: 967  ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLS-PSIQSRTMPVEQVFA-KNFRVAAAM 1024

Query: 1110 ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGH 1144
            +TS+ L W  +P+   +  P  + Y  +    DGH
Sbjct: 1025 KTSVLLSW-EVPDSYKSAVPFKILYNGQSVEVDGH 1058



 Score =  181 bits (459), Expect = 7e-45
 Identities = 208/834 (24%), Positives = 344/834 (41%), Gaps = 102/834 (12%)

Query: 992  LPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
            LP PP +L ++     SVTL +  G     +       A  G  G  +E        +  
Sbjct: 318  LPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA-AGTEGPFQE-------VDGV 369

Query: 1052 DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111
                  +  L+PF+ Y+FR+  VN +G  PPS+  R  +T +  P   P  V  R  S +
Sbjct: 370  ATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRA-RTGEQAPSSPPRRVQARMLSAS 428

Query: 1112 SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEY 1171
            ++ ++W P PE E NG     GY++ Y+          H          T+  L     Y
Sbjct: 429  TMLVQWEP-PE-EPNGLVR--GYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITY 484

Query: 1172 RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGL 1231
             ++V AF A+G GP S T+  +T++ VP+  P +  A   + + + + W  +P  +R   
Sbjct: 485  SLRVLAFTAVGDGPPSPTIQVKTQQGVPAQ-PADFQAEVESDTRIQLSWL-LPPQER--- 539

Query: 1232 VLGYKVMY-KEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP 1290
            ++ Y+++Y   +D D Q +   V  + + S  L  L    LY  Q+ A + +G G  + P
Sbjct: 540  IIMYELVYWAAEDEDQQHK---VTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFT-P 595

Query: 1291 PILERTLDDVPG-PPMGILFPEVRTTSVRLIWQPPAAP--NGIILAYQITHR-LNTTTAN 1346
             I  RT    P  PP  ++   + +T+VR+ W PP A   NG+I  Y + +  ++     
Sbjct: 596  TIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRG 655

Query: 1347 TATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRP 1406
               V+ ++     +   GL+  + Y   + A T  G G  +  ++V T++ D P  P R 
Sbjct: 656  RHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDE-DVPSGPPRK 714

Query: 1407 MVQQEDVRARSVLLSWE--PGSDGLSPVRYYTIQTRELPSGR---------WALHSASVS 1455
             V+ E + + +V + W+    S     +R Y +    L +G            L  A   
Sbjct: 715  -VEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWR 773

Query: 1456 HNASS---FIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTP 1512
               S      +  L P T+Y   V A    GD   S+  + +TT  A P     ++S T 
Sbjct: 774  PEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKP-KIVTTTGAVPGRPTMMISTTA 832

Query: 1513 HTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYS 1572
              T   L++W PP E  + G LLG+R++Y                               
Sbjct: 833  MNTA--LLQWHPPKE--LPGELLGYRLQY------------------------------C 858

Query: 1573 MRNLSRPSLTQYELDN-------LNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTA 1625
              + +RP+   +  D+       L+K   Y  R++  N  G G     +E+   E +P+ 
Sbjct: 859  RADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE-KEIRTPEDLPSG 917

Query: 1626 APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSV 1685
             P+N+ V G T +  ++ W+PP L  +NG I  Y + F +       + + T    +   
Sbjct: 918  FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITT----DTRF 973

Query: 1686 KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE 1745
             L  L   T Y + V A+ + G GP S   Q +T         + + +    TSV +SWE
Sbjct: 974  TLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWE 1033

Query: 1746 APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 1799
             P             Y+   P   +    +V+V G+S   L + DL     Y F
Sbjct: 1034 VPD-----------SYKSAVPFKILYNGQSVEVDGHSMRKL-IADLQPNTEYSF 1075



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 61/221 (27%), Positives = 85/221 (38%), Gaps = 32/221 (14%)

Query: 1719 TQQAAPSAPSSVKFSELTTTSVNVSWEA----PQFPNGILEGYRLVYEPCSPVDGVSKIV 1774
            T +A P  P  +  +E T TSV ++W++    P    GI         P   VDGV+   
Sbjct: 314  TVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVA-TT 372

Query: 1775 TVDVKGNSPLWLKVKDLAEGVTYRFRIRA-KTFTYGPEIEANVTTGPGEGAPGPPGVPII 1833
               + G SP             Y FR+ A  +   GP  EA V    GE AP  P   + 
Sbjct: 373  RYSIGGLSPF----------SEYAFRVLAVNSIGRGPPSEA-VRARTGEQAPSSPPRRVQ 421

Query: 1834 VRYSSA--IAIHWSSGDPGKGPITRYVIEARPSDE---GLWDILIKDIPKEVSSYTFSMD 1888
             R  SA  + + W   +   G +  Y +   P        W     D     +    ++ 
Sbjct: 422  ARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTD-----AGLLTTVG 476

Query: 1889 ILKPGVSYDFRVIAVNDYGFGTPS-----SPSQSVPAQKAN 1924
             L PG++Y  RV+A    G G PS        Q VPAQ A+
Sbjct: 477  SLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD 517



 Score = 38.9 bits (89), Expect = 0.056
 Identities = 35/116 (30%), Positives = 58/116 (50%), Gaps = 14/116 (12%)

Query: 1811 EIEANVTTGPGEGAPGPPGVPIIVRYSSA--IAIHWSSGDPGKGPITRYVIEARPSD-EG 1867
            E  A VT    +  P PP + ++V  ++A  + + W SG+    P+T Y I+ R +  EG
Sbjct: 308  EATAQVTV---KALPKPP-IDLVVTETTATSVTLTWDSGN--SEPVTYYGIQYRAAGTEG 361

Query: 1868 LWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKA 1923
             +  +       V++  +S+  L P   Y FRV+AVN  G G PS   ++   ++A
Sbjct: 362  PFQEV-----DGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQA 412


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  251 bits (641), Expect = 5e-66
 Identities = 279/1029 (27%), Positives = 442/1029 (42%), Gaps = 111/1029 (10%)

Query: 233  VTLECVANAR---PLIKLHIIWKKDGVLLSGGISDHNRRLT-----IPNPTGS-----DA 279
            V L+C A +    P+IK    WKKDG+ L+ G+ +  ++L+     I N   S     D 
Sbjct: 57   VLLDCSAESDRGVPVIK----WKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDE 112

Query: 280  GYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPS 339
            G Y+CEA L  S    + R A ++V  P +F+ + E  +TA M   V + C+  G P P+
Sbjct: 113  GLYQCEASLGDSG-SIISRTAKVAVAGPLRFLSQTES-VTAFMGDTVLLKCEVIGEPMPT 170

Query: 340  ITWYKDAA-VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT 398
            I W K+   +  +   +R      G LQIS L P D G+++C ARN A   +T     V 
Sbjct: 171  IHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASS-RTGNEAEVR 229

Query: 399  SIA-PNITRG------PLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPR 451
             ++ P + R       P +   I+G   VL C  SG P P+ TW +GE ++    ++  +
Sbjct: 230  ILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVI---QLRSKK 286

Query: 452  FTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGT 511
            ++ L   +LLIS     D+G YTC+ T       ASA+L V         P +    +  
Sbjct: 287  YSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESM 346

Query: 512  QASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRV 571
                 C V+  P  T+   W K+G  +    +   ++    +L I      D G Y C  
Sbjct: 347  DIEFECTVSGKPVPTVN--WMKNGDVVIPSDY--FQIVGGSNLRILGVVKSDEGFYQCVA 402

Query: 572  ISAGGNDSRSAHLRVRQ--------LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLI 623
             +  GN   SA L V +        LP AP   V  L  V  R + L+W  P +    + 
Sbjct: 403  ENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVL--VSSRFVRLSWRPPAEAKGNIQ 460

Query: 624  RYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERV 683
             + +  S         L +  P +  +TV  L P   Y FR+ A N+ G G+ S+  +  
Sbjct: 461  TFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA 520

Query: 684  SLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKN 743
            + PE     P +N+ A   +  SI+I W+PP  ++ NG ++GY  R     +  G + +N
Sbjct: 521  TQPELQVPGPVENLQAVSTSPTSILITWEPP--AYANGPVQGY--RLFCTEVSTGKE-QN 575

Query: 744  ITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEAT 803
            I + D  +  LE L  +T Y +   AYN  G GV +  +T  TL  VP+ PP NV  E  
Sbjct: 576  I-EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVV 634

Query: 804  NSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKK 863
            NS +I+ +W  P     NG   GYK+   +  +  E  M T  PN   ++   F +GL+K
Sbjct: 635  NSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGE--METLEPN---NLWYLF-TGLEK 688

Query: 864  FTEYFTSVLCFTTPGDGPRS------TPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQE 917
             ++Y   V   T  G GP S      TP+       VP     L      +  + +SW  
Sbjct: 689  GSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTNCII-MSWTP 747

Query: 918  PGEKNGILTGYRIS------WEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAM 971
            P   N ++ GY I       + E  R +++  +        Y +  L + + Y I + A 
Sbjct: 748  PLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY--------YSIERLESSSHYVISLKAF 799

Query: 972  TSKGQG---QVSASTISSGVP-------PELPGPPTNLG------ISNIGPRSVTL---Q 1012
             + G+G     SA+T S   P       P L   PT++       +  +G ++V L    
Sbjct: 800  NNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDA 859

Query: 1013 FRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQL-SNEPDARSMEVPDLNPFTCYSFR 1070
             R  + D     ++   E ++  V     +    +  S +  + S     L P T Y F 
Sbjct: 860  VRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTMYEFS 919

Query: 1071 MRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSL--RTASETSLWLRWMPLPEMEYNGN 1128
            +       +S  S  +    T +A P  AP ++++  R     ++ + W   P +E NG 
Sbjct: 920  VMVTKNRRSSTWSMTAH-ATTYEAAPTSAPKDLTVITREGKPRAVIVSWQ--PPLEANG- 975

Query: 1129 PESVGYKIKYSRSDGHGKTLSHVVQDRVERD---YTIEDLEEWTEYRVQVQAFNAIGSGP 1185
             +   Y + Y+        +   + + +  D   + I DL   T Y  ++QA N+ G GP
Sbjct: 976  -KITAYILFYTLD--KNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGP 1032

Query: 1186 WSQTVVGRT 1194
             S  ++ RT
Sbjct: 1033 LSDPILFRT 1041



 Score =  157 bits (397), Expect = 1e-37
 Identities = 191/708 (26%), Positives = 285/708 (40%), Gaps = 105/708 (14%)

Query: 954  RVTGLTALTTYTIEVAAMTSKGQGQVSASTI--SSGVPPE--LPGPPTNLGISNIGPRSV 1009
            R+ G+        +  A    G  Q SA  I     +P    LP  P ++    +  R V
Sbjct: 386  RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFV 445

Query: 1010 TLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSF 1069
             L +RP  + K +I  + V       G+  E  L    + +P +  + V +L P   Y+F
Sbjct: 446  RLSWRPPAEAKGNIQTFTVF--FSREGDNRERALN---TTQPGSLQLTVGNLKPEAMYTF 500

Query: 1070 RMRQVNIVGTSPPSQPSRKIQT---LQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYN 1126
            R+   N  G    SQP  K+ T   LQ P  +   N+   + S TS+ + W P     Y 
Sbjct: 501  RVVAYNEWGPGESSQPI-KVATQPELQVPGPVE--NLQAVSTSPTSILITWEP---PAYA 554

Query: 1127 GNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD---YTIEDLEEWTEYRVQVQAFNAIGS 1183
              P   GY++ +      GK      +  +E D   Y +E L+++TEY ++  A+N  G 
Sbjct: 555  NGPVQ-GYRL-FCTEVSTGK------EQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGP 606

Query: 1184 GPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYK--- 1240
            G  +  +   T   VPS+ P NVS     S S+ V W   P   +NG + GYK+ ++   
Sbjct: 607  GVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTT 666

Query: 1241 ---EKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSH---PPILE 1294
               E ++      W +          TGL K   Y  QV A T  G G PS+       E
Sbjct: 667  RRGEMETLEPNNLWYL---------FTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPE 717

Query: 1295 RTLDD--VPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEV 1352
              LD+  VP  P   L    +T  + + W PP  PN ++  Y I + + +  A T  V+ 
Sbjct: 718  NDLDESQVPDQPSS-LHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVD- 775

Query: 1353 LAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPP--------- 1403
                 R Y+   L+  S Y+  + A    G G        T    D   P          
Sbjct: 776  --SKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDF 833

Query: 1404 -------SRPMVQQEDVRA-----RSVLLSWE----PGSDGLSPVRYYTIQTRELPSGRW 1447
                   S PM+    V+A      +V +SW     P +   S VR YT++ R   S   
Sbjct: 834  PTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASA 893

Query: 1448 ALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI 1507
               S   +  + S+    LKP T Y+F V  T +   S +S  + + TT +AAP  AP  
Sbjct: 894  KYKSEDTT--SLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHA-TTYEAAPTSAPKD 950

Query: 1508 LSVTPH--TTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWA 1565
            L+V        +V++ WQPP E   NG +  + + Y           TL   N P   W 
Sbjct: 951  LTVITREGKPRAVIVSWQPPLE--ANGKITAYILFY-----------TL-DKNIPIDDWI 996

Query: 1566 ELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPP 1613
                   M  +S   LT +++ +LN    Y  R+   N+ G GP S P
Sbjct: 997  -------METISGDRLT-HQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036



 Score =  136 bits (343), Expect = 2e-31
 Identities = 155/640 (24%), Positives = 252/640 (39%), Gaps = 82/640 (12%)

Query: 911  LKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA 970
            +++SW+ P E  G +  + + +        R  +     +L+  V  L     YT  V A
Sbjct: 445  VRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVA 504

Query: 971  MTSKGQGQVSASTISSGVPPEL--PGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLV 1028
                G G+ S+  I     PEL  PGP  NL   +  P S+ + + P       +  + +
Sbjct: 505  YNEWGPGE-SSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRL 563

Query: 1029 EAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
                  V  G+E  +      E D  S ++  L  FT YS R    N  G    S     
Sbjct: 564  FCT--EVSTGKEQNI------EVDGLSYKLEGLKKFTEYSLRFLAYNRYGPG-VSTDDIT 614

Query: 1089 IQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL 1148
            + TL   P   P NVSL   +  S+ + W+P P    NG     GYKI+      H KT 
Sbjct: 615  VVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNG--FITGYKIR------HRKTT 666

Query: 1149 SHVVQDRVERD---YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRES--VPSSGP 1203
                 + +E +   Y    LE+ ++Y  QV A    G+GP S      T E+    S  P
Sbjct: 667  RRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVP 726

Query: 1204 TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMY-------KEKDSDTQPRFWLVEGN 1256
               S+L     +  +  S  P  + N +V GY + Y       +    D++ R++ +E  
Sbjct: 727  DQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIERL 786

Query: 1257 SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERT-------------LDDVPG- 1302
             S S           Y + + AF   G+G P +     R+             LDD P  
Sbjct: 787  ESSSH----------YVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTS 836

Query: 1303 ---------PPMGILFPEVRTTSVRLIWQPPAAPNG--IILAYQITHRLNTTTANTATVE 1351
                     PP+G+    +   +VR+ W   + P           T R  T+ + +A  +
Sbjct: 837  VPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYK 896

Query: 1352 VLAPSARQYTATGLKPESVYLFRI-TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQ 1410
                ++  YTATGLKP ++Y F +   + R+    +  A   T E      P    ++ +
Sbjct: 897  SEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITR 956

Query: 1411 EDVRARSVLLSWEPGSDG----LSPVRYYTIQTRELPSGRWALHSAS---VSHNASSFIV 1463
            E  + R+V++SW+P  +      + + +YT+  + +P   W + + S   ++H      +
Sbjct: 957  EG-KPRAVIVSWQPPLEANGKITAYILFYTLD-KNIPIDDWIMETISGDRLTHQIMDLNL 1014

Query: 1464 DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDE 1503
            D     T Y FR++A N  G    S+     T     PD+
Sbjct: 1015 D-----TMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDK 1049



 Score =  134 bits (336), Expect = 1e-30
 Identities = 238/1075 (22%), Positives = 390/1075 (36%), Gaps = 168/1075 (15%)

Query: 28   FKTEPVRTQVHLEGNRLVLTCMAEGSWPLE-FKW----LH-------NNRELTKFSLEYR 75
            F +EP    V + G  ++L C AE    +   KW    +H         ++L+  SL  +
Sbjct: 42   FLSEP-SDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQ 100

Query: 76   YMITSLD-RTHAGFYRCIVR-NRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIR 133
             ++ S   +   G Y+C       G+++ R  +V VA    F    +  +   G+  +++
Sbjct: 101  NILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLK 160

Query: 134  APRIASFPQPQVTWFR---DGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKN 190
               I   P P + W +   D   IP  SR+ +     L I      D G Y   A N  +
Sbjct: 161  CEVIGE-PMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219

Query: 191  GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARP------- 243
                    + +    +  P        +  P N   + G   V LEC  +  P       
Sbjct: 220  SRTGNEAEVRI----LSDPGLHRQLYFLQRPSNVVAIEGKDAV-LECCVSGYPPPSFTWL 274

Query: 244  ----LIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 299
                +I+L     K   LL G        L I N T  D+G Y C    ++ ++ +    
Sbjct: 275  RGEEVIQLR---SKKYSLLGGS------NLLISNVTDDDSGMYTCVVTYKNENISA---S 322

Query: 300  AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQ 359
            A L+VL PP F+  P  ++ A     ++  C   G P P++ W K+  VV       F+ 
Sbjct: 323  AELTVLVPPWFLNHPS-NLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--FQI 379

Query: 360  RNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV-------TSIAPNITRGPLDST 412
                 L+I G+V  D G +QC A N AG  QTS  L V       +S+ P+  R  +   
Sbjct: 380  VGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVP-V 438

Query: 413  VIDGMSVVLA----CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS 468
            ++    V L+     E  G  +    +   E     G  +       + GSL ++  ++ 
Sbjct: 439  LVSSRFVRLSWRPPAEAKGNIQTFTVFFSRE-----GDNRERALNTTQPGSLQLTVGNLK 493

Query: 469  DAGTYT--CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT 526
                YT   +A N  G  E+S  + V  +  +  P      ++  QA     V+  P  +
Sbjct: 494  PEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVP----GPVENLQA-----VSTSP-TS 543

Query: 527  IRYIWEKDGATLG-------------TESHPRIRLDRNGSLHISQTWSGDIGTYTCRVIS 573
            I   WE      G             T     I +D    L            Y+ R ++
Sbjct: 544  ILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVD---GLSYKLEGLKKFTEYSLRFLA 600

Query: 574  -----AGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE 628
                  G +      + +  +P AP   V+ L  V  R+I ++W  P  G         +
Sbjct: 601  YNRYGPGVSTDDITVVTLSDVPSAPPQNVS-LEVVNSRSIKVSWLPPPSGTQNGFITGYK 659

Query: 629  MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ----FSKDTERVS 684
            +          + +++P        GL     Y F++ A+   G G     ++ +T    
Sbjct: 660  IRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPEND 719

Query: 685  LPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNI 744
            L E      P ++    +TN  I++ W PP   + N +++GYII Y   G+   Y     
Sbjct: 720  LDESQVPDQPSSLHVRPQTN-CIIMSWTPP--LNPNIVVRGYIIGY---GVGSPYAETVR 773

Query: 745  TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGV--YSSKVTEWTLQ-------------- 788
             D+      +E L   ++Y I + A+N+AG GV  Y S  T                   
Sbjct: 774  VDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDF 833

Query: 789  -------GVPTVPPGNVHAEATNSTTIRFTW---NAPSPQFINGINQGYKLIAWEPEQEE 838
                     P +PP  V A A     +R +W   + P  Q  + +      + W      
Sbjct: 834  PTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVR--LYTVRWRTSFS- 890

Query: 839  EVTMVTARPNFQDSIHVGFVS-GLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGP 897
                 +A+   +D+  + + + GLK  T Y  SV+          S      T+E  P  
Sbjct: 891  ----ASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTS 946

Query: 898  VGH---LSFSEILDTSLKVSWQEPGEKNGILTGYRI-----------SWEEYNRTNTRVT 943
                  +   E    ++ VSWQ P E NG +T Y +            W     +  R+T
Sbjct: 947  APKDLTVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLT 1006

Query: 944  HYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTN 998
            H + ++ L+         T Y   + A  SKG G +S   +   +  E P    N
Sbjct: 1007 HQIMDLNLD---------TMYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMAN 1052



 Score =  117 bits (293), Expect = 1e-25
 Identities = 208/925 (22%), Positives = 330/925 (35%), Gaps = 200/925 (21%)

Query: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256
            SV  S P +V  +    SS  VR S  P A+  G +  + V +  ++ D + R       
Sbjct: 426  SVLPSAPRDVVPVLV--SSRFVRLSWRPPAEAKGNIQTFTVFFS-REGDNRERALNTTQP 482

Query: 1257 SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP-PILERTLDDVPGPPMGILFPEVRTT 1315
             S    +  L    +Y  +V+A+   G G  S P  +  +    VPGP   +       T
Sbjct: 483  GSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPT 542

Query: 1316 SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRI 1375
            S+ + W+PPA  NG +  Y    RL  T  +T   + +      Y   GLK  + Y  R 
Sbjct: 543  SILITWEPPAYANGPVQGY----RLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRF 598

Query: 1376 TAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSP--VR 1433
             A  R G G + + + V T       PP    V  E V +RS+ +SW P   G     + 
Sbjct: 599  LAYNRYGPGVSTDDITVVTLSDVPSAPPQN--VSLEVVNSRSIKVSWLPPPSGTQNGFIT 656

Query: 1434 YYTIQTREL----------PSGRWALHS-----ASVSHNASSFIVDRLKPFTSYKFRVKA 1478
             Y I+ R+           P+  W L +     +  S   S+  V+   P +++      
Sbjct: 657  GYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETP 716

Query: 1479 TNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFR 1538
             ND+ +S+              PD+ P+ L V P T   +++ W PP    I  ++ G+ 
Sbjct: 717  ENDLDESQ-------------VPDQ-PSSLHVRPQTNC-IIMSWTPPLNPNI--VVRGYI 759

Query: 1539 IRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIR 1598
            I Y              G+ +P   +AE   + S +         Y ++ L     Y I 
Sbjct: 760  IGY--------------GVGSP---YAETVRVDSKQRY-------YSIERLESSSHYVIS 795

Query: 1599 MSVYNAVGEG--------------PSSPPQEVFVGEAVPTAAPR---------NVVVHGA 1635
            +  +N  GEG              P+ P     + +  PT+ P           V     
Sbjct: 796  LKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVAL 855

Query: 1636 TATQLDVTW--EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG- 1692
            T   + V+W     P + +  +++ Y            T R +T F A    K ++ T  
Sbjct: 856  THDAVRVSWADNSVPKNQKTSEVRLY------------TVRWRTSFSASAKYKSEDTTSL 903

Query: 1693 -YTA--------YMVSVAAFNAAGDGPRSTPTQGQTQQAAP-SAPS--SVKFSELTTTSV 1740
             YTA        Y  SV           S      T +AAP SAP   +V   E    +V
Sbjct: 904  SYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAV 963

Query: 1741 NVSWEAPQFPNGILEGYRLVY--EPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYR 1798
             VSW+ P   NG +  Y L Y  +   P+D       ++      L  ++ DL     Y 
Sbjct: 964  IVSWQPPLEANGKITAYILFYTLDKNIPIDD----WIMETISGDRLTHQIMDLNLDTMYY 1019

Query: 1799 FRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYV 1858
            FRI+A+                     GP   PI+ R          + D G        
Sbjct: 1020 FRIQAR----------------NSKGVGPLSDPILFRTLKVEHPDKMANDQG-------- 1055

Query: 1859 IEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSV 1918
               R  D G W +    I +                        +N+   G    P  SV
Sbjct: 1056 ---RHGDGGYWPVDTNLIDRS----------------------TLNEPPIGQMHPPHGSV 1090

Query: 1919 PAQKANPFYEEWWFLVVIALVGLIFILLLVFVLII--RGQSKKYAKKTDSGNSAKSGALG 1976
              QK +        ++++  VG+I +L++V V +I  R  S +  KK  + ++ K     
Sbjct: 1091 TPQKNSNL-----LVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKG-- 1143

Query: 1977 HSEMMSLDESSFPALELNNRRLSVKNSFCRKNGLYTRSPPRPSPGSLHYSDEDVTKYNDL 2036
                 S  +   P L +++  + +KN              +PS       D  +    DL
Sbjct: 1144 -----SQKDLRPPDLWIHHEEMEMKNI------------EKPSGTDPAGRDSPIQSCQDL 1186

Query: 2037 IP-AESSSLTEKPSEISDSQGSDSE 2060
             P + S S T+  S+ +   G D+E
Sbjct: 1187 TPVSHSQSETQLGSKSTSHSGQDTE 1211



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 87/344 (25%), Positives = 143/344 (41%), Gaps = 53/344 (15%)

Query: 1474 FRVKATNDIGDSEFSEES-------ESLTTLQAAP-DEAPTILSVTPHTTTSVLIRWQPP 1525
            ++  A N+ G+++ S +         S + L +AP D  P ++S     +  V + W+PP
Sbjct: 398  YQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVS-----SRFVRLSWRPP 452

Query: 1526 AEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYE 1585
            AE K  G +  F +            F+  G N   A            N ++P   Q  
Sbjct: 453  AEAK--GNIQTFTVF-----------FSREGDNRERAL-----------NTTQPGSLQLT 488

Query: 1586 LDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAP-RNVVVHGATATQLDVTW 1644
            + NL     Y  R+  YN  G G SS P +V     +    P  N+     + T + +TW
Sbjct: 489  VGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITW 548

Query: 1645 EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFN 1704
            EPP     NG +QGY+++  E   G    + + + +   S KL+ L  +T Y +   A+N
Sbjct: 549  EPPAY--ANGPVQGYRLFCTEVSTG----KEQNIEVDGLSYKLEGLKKFTEYSLRFLAYN 602

Query: 1705 AAGDGPRSTPTQGQTQQAAPSA-PSSVKFSELTTTSVNVSWEAPQ--FPNGILEGYRLVY 1761
              G G  +      T    PSA P +V    + + S+ VSW  P     NG + GY++ +
Sbjct: 603  RYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRH 662

Query: 1762 EPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT 1805
                     ++   ++    + LW     L +G  Y F++ A T
Sbjct: 663  RK------TTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMT 700



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 86/311 (27%), Positives = 137/311 (44%), Gaps = 29/311 (9%)

Query: 1613 PQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLT 1672
            P+      +V  +APR+VV    ++  + ++W PP      G+IQ + ++F  ++ G+  
Sbjct: 418  PKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPA--EAKGNIQTFTVFF--SREGDNR 473

Query: 1673 ER-VKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQA--APSAPSS 1729
            ER + T       + + NL     Y   V A+N  G G  S P +  TQ     P    +
Sbjct: 474  ERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVEN 533

Query: 1730 VKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVK 1789
            ++    + TS+ ++WE P + NG ++GYRL    C+ V    K   ++V G   L  K++
Sbjct: 534  LQAVSTSPTSILITWEPPAYANGPVQGYRLF---CTEV-STGKEQNIEVDG---LSYKLE 586

Query: 1790 DLAEGVTYRFRIRAKTFTYGPEIEAN----VTTGPGEGAPGPPGVPIIVRYSSAIAIHWS 1845
             L +   Y  R  A    YGP +  +    VT      AP P  V + V  S +I + W 
Sbjct: 587  GLKKFTEYSLRFLAYN-RYGPGVSTDDITVVTLSDVPSAP-PQNVSLEVVNSRSIKVSWL 644

Query: 1846 SGDPG--KGPITRYVIEARPSD-EGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
                G   G IT Y I  R +   G  + L      E ++  +    L+ G  Y F+V A
Sbjct: 645  PPPSGTQNGFITGYKIRHRKTTRRGEMETL------EPNNLWYLFTGLEKGSQYSFQVSA 698

Query: 1903 VNDYGFGTPSS 1913
            +   G G PS+
Sbjct: 699  MTVNGTGPPSN 709



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 47/200 (23%), Positives = 73/200 (36%), Gaps = 9/200 (4%)

Query: 27  YFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEY------RYMITS 80
           YF   P    V +EG   VL C   G  P  F WL     +   S +Y        +I++
Sbjct: 241 YFLQRPSNV-VAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISN 299

Query: 81  LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF 140
           +    +G Y C+V  +    +    E+ V     F         ++    +     ++  
Sbjct: 300 VTDDDSGMYTCVVTYK-NENISASAELTVLVPPWF-LNHPSNLYAYESMDIEFECTVSGK 357

Query: 141 PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPIT 200
           P P V W ++G  + PS    I   + L IL  V  D G Y   A N+      ++Q I 
Sbjct: 358 PVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIV 417

Query: 201 LTVENVGGPADPIAPTIIIP 220
                      P AP  ++P
Sbjct: 418 PKPAIPSSSVLPSAPRDVVP 437


>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
           sapiens]
          Length = 1248

 Score =  248 bits (633), Expect = 5e-65
 Identities = 255/1019 (25%), Positives = 419/1019 (41%), Gaps = 69/1019 (6%)

Query: 1   MWGLLIWTLLALHQIRAARAQDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKW 60
           +W LL+ +   L QI     +    P    +  R  V    + + L C A G   ++F+W
Sbjct: 8   VWPLLLCSPCLLIQIPEELMEP---PVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRW 64

Query: 61  LHNNRELTKFSLEYRYMITSLDRTHAG-----------------FYRCIVRNRMGALLQR 103
               R+   F  +    +T     H+G                  YRC   N++G  +  
Sbjct: 65  ---TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAMSH 121

Query: 104 QTEVQVAYMGSF-EEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDG-RKIPPSSRIA 161
           +  +       + +E  K   V  GE+ V+      S    ++ W       I    R+ 
Sbjct: 122 EIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT 181

Query: 162 ITLENTLVILSTVAPDAGRYYV-QAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIP 220
           +     L   + +  D    Y+  A           +PI L V+      D   P ++ P
Sbjct: 182 MGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDR-KPRLLFP 240

Query: 221 PKNTS--VVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS--DHNRRLTIPNPTG 276
             ++S  V      + LEC+A   P   +  + +  G + +  ++  +HN+ L +     
Sbjct: 241 TNSSSHLVALQGQPLVLECIAEGFPTPTIKWL-RPSGPMPADRVTYQNHNKTLQLLKVGE 299

Query: 277 SDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVP 336
            D G Y C   L  +S+ S     Y++V   P ++ +P+ H+    E    + CQ +G P
Sbjct: 300 EDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGE-TARLDCQVQGRP 355

Query: 337 PPSITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYL 395
            P +TW      V E+ K  ++R +  G L +S + P DT + QC ARN  G +  + Y+
Sbjct: 356 QPEVTWRINGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEARNRHGLLLANAYI 414

Query: 396 AVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPAITW--QKGERILASGSVQLPRF 452
            V  +   I T        + G +  L C+  GAP P++ W  + G  +L     Q  RF
Sbjct: 415 YVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-----QDERF 469

Query: 453 TPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQ 512
            P  +G+L I     +D G Y CLA N +      A+L V   T+IT+ P+     KG++
Sbjct: 470 FPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKGSR 529

Query: 513 ASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVI 572
            +  C  + DP +     W  DG  L            +G L I      D G Y+C V 
Sbjct: 530 VTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSC-VA 588

Query: 573 SAGGN--DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMS 630
           S   +  +SR+  L V      P   ++ L  + +  + ++W+   D N+P+ +Y +E  
Sbjct: 589 STELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFE 648

Query: 631 ENN-AP--WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE 687
           +   AP  W   L  V    TS T+K L P   Y FR+ A+N  G G+ S  +E V  PE
Sbjct: 649 DKEMAPEKW-YSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVTPE 706

Query: 688 EPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDA 747
             P   P +V   G    +++I W+P      N     Y +++   G    +Q + ++D 
Sbjct: 707 AAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVSDP 766

Query: 748 DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTT 807
               L++ +   +  YEI+V A NS G G        ++ +  P   P     E  NS+ 
Sbjct: 767 ---FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSA 823

Query: 808 IRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVG------FVSGL 861
           +   W       + G  +GY +  W   +E      + R   +D + V        +SGL
Sbjct: 824 VLVKWRPVDLAQVKGHLRGYNVTYW---REGSQRKHSKRHIHKDHVVVPANTTSVILSGL 880

Query: 862 KKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEK 921
           + ++ Y   V  F   G GP S      T E VPG    L      +TSL + WQ P   
Sbjct: 881 RPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSH 939

Query: 922 NGILTGYRISWEEYNRTNT-RVTHYLPNVTLE-YRVTGLTALTTYTIEVAAMTSKGQGQ 978
           NG+LTGY +S+   +     +++  L +  L  + +T L+    Y  ++ A T +G G+
Sbjct: 940 NGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGE 998



 Score =  149 bits (377), Expect = 2e-35
 Identities = 154/598 (25%), Positives = 257/598 (42%), Gaps = 67/598 (11%)

Query: 1400 PQPPSRPMVQQEDVRARS-VLLSWEPGSDGLSPVRYYTIQ--TRELPSGRWALHSASVSH 1456
            P P  R ++    +  +S V +SW P  D  +P+  Y I+   +E+   +W        +
Sbjct: 607  PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN 666

Query: 1457 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTT 1516
              S+ +  +L P+  Y FRV A N  G  E S  SE++ T +AAP++ P  +    + TT
Sbjct: 667  QTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETT 724

Query: 1517 SVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL 1576
            +++I W+P      N   + +R+++R    +G RG            W E       + +
Sbjct: 725  NMVITWKPLRWMDWNAPQVQYRVQWRP---QGTRG-----------PWQE-------QIV 763

Query: 1577 SRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGAT 1636
            S P L    + N +    YEI++   N+ G+GP       + GE  P A P    +    
Sbjct: 764  SDPFLV---VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILN 820

Query: 1637 ATQLDVTWEPPPLDSQNGDIQGYKIYFWE--AQRGNLTERVKTLFLA----ENSVKLKNL 1690
            ++ + V W P  L    G ++GY + +W   +QR +    +    +       SV L  L
Sbjct: 821  SSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGL 880

Query: 1691 TGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFP 1750
              Y++Y + V AFN  G GP S  T   T +  P  P ++     + TS+ + W+ P   
Sbjct: 881  RPYSSYHLEVQAFNGRGSGPASEFT-FSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSH 939

Query: 1751 NGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
            NG+L GY L Y P    +G    ++ +++        + DL+  + YRF+++A T   GP
Sbjct: 940  NGVLTGYVLSYHPLD--EGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATT-KEGP 996

Query: 1811 EIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWS--SGDPGKGPIT---RYVIEARPSD 1865
              EA V  G   G     G+      S+    ++S  S  P +G        + +A   +
Sbjct: 997  G-EAIVREG---GTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEE 1052

Query: 1866 EGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRV---------IAVNDYGFGTPSSPSQ 1916
            +G   +  + +    SSYT   D L+P   Y+  +         +AV   G G    P  
Sbjct: 1053 KGGASLSPQYVSYNQSSYT-QWD-LQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLP-- 1108

Query: 1917 SVPAQKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGA 1974
              PA     F  E WF+  ++ + L+ ++LL+   I R +  KY+ K        S A
Sbjct: 1109 --PA----GFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEA 1160



 Score =  146 bits (369), Expect = 2e-34
 Identities = 246/1090 (22%), Positives = 416/1090 (38%), Gaps = 117/1090 (10%)

Query: 141  PQPQVTWFRDGRKIPPSSRIAITL-----ENTLVILSTVAPDAGRYYVQAVNDKNGDNKT 195
            P+ Q  W RDG    P   + +T+       +  I    +  A R+  Q +      NK 
Sbjct: 58   PEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF--QGIYRCFASNKL 115

Query: 196  SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIK-LHIIWKKD 254
               ++  +  +   A P  P   + P    V  G S V L C  N  P  + L I W   
Sbjct: 116  GTAMSHEIRLMAEGA-PKWPKETVKP--VEVEEGES-VVLPC--NPPPSAEPLRIYWMNS 169

Query: 255  GVLL----SGGISDHNRRLTIPNPTGSDA-GYYECEA-------VLRSSSVPSVVRGAYL 302
             +L            N  L   N   SD    Y C A       +++   +   V+    
Sbjct: 170  KILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNS 229

Query: 303  SVLEPPQ--FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 360
             +   P+  F      H+ A   + + + C A+G P P+I W + +  +  +++T   Q 
Sbjct: 230  MIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTY--QN 287

Query: 361  NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
            ++  LQ+  +  +D G ++C A N+ G  + + Y+ V + AP     P       G +  
Sbjct: 288  HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEA-APYWLHKPQSHLYGPGETAR 346

Query: 421  LACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATN 479
            L C+  G P+P +TW+  G  +      Q  R   ++ G+L++S    SD     C A N
Sbjct: 347  LDCQVQGRPQPEVTWRINGIPVEELAKDQKYR---IQRGALILSNVQPSDTMVTQCEARN 403

Query: 480  SRGVDEASADL-VVWARTRI-TKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGAT 537
              G+  A+A + VV    +I T   Q    ++G+ A ++C     P  +++++ ++DG T
Sbjct: 404  RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGTT 462

Query: 538  LGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPV 597
            +  +   R     NG+L I    + D G Y C   +   N +  A+L+V+      + P 
Sbjct: 463  VLQDE--RFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP- 519

Query: 598  ATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVP 657
               ST+E++   +T+T     +  L   I    +        L  +          G + 
Sbjct: 520  --RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFIEDGRLV 572

Query: 658  ARSYQFRLCAVNDVGKGQFSKDTE------RVSLPEEPPTAPPQNVIASGR---TNQSIM 708
              S  +     +D G       TE      R  L       P   ++ S     T   + 
Sbjct: 573  IHSLDY-----SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR 627

Query: 709  IQWQPPPESHQNGILKGYIIRYCLAGLPVG--YQFKNITDADVNNLLLEDLIIWTNYEIE 766
            + W P  E H N  ++ Y I +    +     Y    +     +  L   L  + +Y   
Sbjct: 628  VSWSPA-EDH-NAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL--KLSPYVHYTFR 683

Query: 767  VAAYNSAGLGVYSS-KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTW--------NAPSP 817
            V A N  G G  S    T  T +  P   P +V  E   +T +  TW        NAP  
Sbjct: 684  VTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQV 743

Query: 818  QFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF--VSGLKKFTEYFTSVLCFT 875
            Q+          + W P+        T  P  +  +   F  VS    F  Y   V    
Sbjct: 744  QY---------RVQWRPQG-------TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVN 787

Query: 876  TPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTS-LKVSWQ--EPGEKNGILTGYRIS- 931
            + G GP     +  + ED P  +  L   EIL++S + V W+  +  +  G L GY ++ 
Sbjct: 788  SQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTY 847

Query: 932  WEEYNRTNTRVTHY------LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
            W E ++      H       +P  T    ++GL   ++Y +EV A   +G G  S  T S
Sbjct: 848  WREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFS 907

Query: 986  SGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIH 1045
            +  P  +PG P  L +      S+ L+++P       ++ +++      + EG +  L  
Sbjct: 908  T--PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH--PLDEGGKGQLSF 963

Query: 1046 QLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSL 1105
             L  +P+ R+  + DL+P   Y F+++     G             L    D    N+S 
Sbjct: 964  NL-RDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDF--GNIS- 1019

Query: 1106 RTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDL 1165
             TA E    + W+P  E + N     +    K    +  G +LS       +  YT  DL
Sbjct: 1020 ATAGENYSVVSWVP-KEGQCNFRFHIL---FKALGEEKGGASLSPQYVSYNQSSYTQWDL 1075

Query: 1166 EEWTEYRVQV 1175
            +  T+Y + +
Sbjct: 1076 QPDTDYEIHL 1085



 Score =  145 bits (367), Expect = 3e-34
 Identities = 127/495 (25%), Positives = 213/495 (43%), Gaps = 27/495 (5%)

Query: 993  PGPPTNLGISNIG---PRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
            PGP   L +S++       V + + P  D    I ++ +E +   +   E+W   + L  
Sbjct: 607  PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP-EKW---YSLGK 662

Query: 1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
             P  ++     L+P+  Y+FR+  +N  G   PS  S  + T +A P+  P +V      
Sbjct: 663  VPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNE 722

Query: 1110 ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWT 1169
             T++ + W PL  M++N     V Y++++      G     +V D       + +   + 
Sbjct: 723  TTNMVITWKPLRWMDWNA--PQVQYRVQWRPQGTRGPWQEQIVSDPF---LVVSNTSTFV 777

Query: 1170 EYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRN 1229
             Y ++VQA N+ G GP  Q  +G + E  P + P         SS++LV+W  V  A   
Sbjct: 778  PYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVK 837

Query: 1230 GLVLGYKVMYKEKDSDTQ------PRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG 1283
            G + GY V Y  + S  +       +  +V   ++ S  L+GL  Y  Y ++V AF   G
Sbjct: 838  GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 897

Query: 1284 DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQIT-HRLNT 1342
             G  S       T + VPG P  +       TS+ L WQPP + NG++  Y ++ H L+ 
Sbjct: 898  SGPASE--FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDE 955

Query: 1343 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQP 1402
                  +  +  P  R +  T L P   Y F++ A T++G GEA      T         
Sbjct: 956  GGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDF 1015

Query: 1403 PSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTI-QTRELPSGRWALHSASVSHNASSF 1461
             +      E+      ++SW P  +G    R++ + +      G  +L    VS+N SS+
Sbjct: 1016 GNISATAGENYS----VVSWVP-KEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSY 1070

Query: 1462 IVDRLKPFTSYKFRV 1476
                L+P T Y+  +
Sbjct: 1071 TQWDLQPDTDYEIHL 1085


>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
            sapiens]
          Length = 1253

 Score =  248 bits (632), Expect = 6e-65
 Identities = 256/1021 (25%), Positives = 419/1021 (41%), Gaps = 68/1021 (6%)

Query: 1    MWGLLIWTLLALHQIRAARAQDDVS--PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEF 58
            +W LL+ +   L QI        V   P    +  R  V    + + L C A G   ++F
Sbjct: 8    VWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQF 67

Query: 59   KWLHNNRELTKFSLEYRYMITSLDRTHAG-----------------FYRCIVRNRMGALL 101
            +W    R+   F  +    +T     H+G                  YRC   N++G  +
Sbjct: 68   RW---TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAM 124

Query: 102  QRQTEVQVAYMGSF-EEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDG-RKIPPSSR 159
              +  +       + +E  K   V  GE+ V+      S    ++ W       I    R
Sbjct: 125  SHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDER 184

Query: 160  IAITLENTLVILSTVAPDAGRYYV-QAVNDKNGDNKTSQPITLTVENVGGPADPIAPTII 218
            + +     L   + +  D    Y+  A           +PI L V+      D   P ++
Sbjct: 185  VTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDR-KPRLL 243

Query: 219  IPPKNTS--VVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS--DHNRRLTIPNP 274
             P  ++S  V      + LEC+A   P   +  + +  G + +  ++  +HN+ L +   
Sbjct: 244  FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL-RPSGPMPADRVTYQNHNKTLQLLKV 302

Query: 275  TGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKG 334
               D G Y C   L  +S+ S     Y++V   P ++ +P+ H+    E    + CQ +G
Sbjct: 303  GEEDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGE-TARLDCQVQG 358

Query: 335  VPPPSITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTST 393
             P P +TW      V E+ K  ++R +  G L +S + P DT + QC ARN  G +  + 
Sbjct: 359  RPQPEVTWRINGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEARNRHGLLLANA 417

Query: 394  YLAVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPAITW--QKGERILASGSVQLP 450
            Y+ V  +   I T        + G +  L C+  GAP P++ W  + G  +L     Q  
Sbjct: 418  YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-----QDE 472

Query: 451  RFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKG 510
            RF P  +G+L I     +D G Y CLA N +      A+L V   T+IT+ P+     KG
Sbjct: 473  RFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKG 532

Query: 511  TQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCR 570
            ++ +  C  + DP +     W  DG  L            +G L I      D G Y+C 
Sbjct: 533  SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSC- 591

Query: 571  VISAGGN--DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE 628
            V S   +  +SR+  L V      P   ++ L  + +  + ++W+   D N+P+ +Y +E
Sbjct: 592  VASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIE 651

Query: 629  MSENN-AP--WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL 685
              +   AP  W   L  V    TS T+K L P   Y FR+ A+N  G G+ S  +E V  
Sbjct: 652  FEDKEMAPEKW-YSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVT 709

Query: 686  PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNIT 745
            PE  P   P +V   G    +++I W+P      N     Y +++   G    +Q + ++
Sbjct: 710  PEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS 769

Query: 746  DADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNS 805
            D     L++ +   +  YEI+V A NS G G        ++ +  P   P     E  NS
Sbjct: 770  DP---FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNS 826

Query: 806  TTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVG------FVS 859
            + +   W       + G  +GY +  W   +E      + R   +D + V        +S
Sbjct: 827  SAVLVKWRPVDLAQVKGHLRGYNVTYW---REGSQRKHSKRHIHKDHVVVPANTTSVILS 883

Query: 860  GLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPG 919
            GL+ ++ Y   V  F   G GP S      T E VPG    L      +TSL + WQ P 
Sbjct: 884  GLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPL 942

Query: 920  EKNGILTGYRISWEEYNRTNT-RVTHYLPNVTLE-YRVTGLTALTTYTIEVAAMTSKGQG 977
              NG+LTGY +S+   +     +++  L +  L  + +T L+    Y  ++ A T +G G
Sbjct: 943  SHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002

Query: 978  Q 978
            +
Sbjct: 1003 E 1003



 Score =  149 bits (377), Expect = 2e-35
 Identities = 154/598 (25%), Positives = 257/598 (42%), Gaps = 67/598 (11%)

Query: 1400 PQPPSRPMVQQEDVRARS-VLLSWEPGSDGLSPVRYYTIQ--TRELPSGRWALHSASVSH 1456
            P P  R ++    +  +S V +SW P  D  +P+  Y I+   +E+   +W        +
Sbjct: 612  PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN 671

Query: 1457 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTT 1516
              S+ +  +L P+  Y FRV A N  G  E S  SE++ T +AAP++ P  +    + TT
Sbjct: 672  QTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETT 729

Query: 1517 SVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL 1576
            +++I W+P      N   + +R+++R    +G RG            W E       + +
Sbjct: 730  NMVITWKPLRWMDWNAPQVQYRVQWRP---QGTRG-----------PWQE-------QIV 768

Query: 1577 SRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGAT 1636
            S P L    + N +    YEI++   N+ G+GP       + GE  P A P    +    
Sbjct: 769  SDPFLV---VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILN 825

Query: 1637 ATQLDVTWEPPPLDSQNGDIQGYKIYFWE--AQRGNLTERVKTLFLA----ENSVKLKNL 1690
            ++ + V W P  L    G ++GY + +W   +QR +    +    +       SV L  L
Sbjct: 826  SSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGL 885

Query: 1691 TGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFP 1750
              Y++Y + V AFN  G GP S  T   T +  P  P ++     + TS+ + W+ P   
Sbjct: 886  RPYSSYHLEVQAFNGRGSGPASEFT-FSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSH 944

Query: 1751 NGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
            NG+L GY L Y P    +G    ++ +++        + DL+  + YRF+++A T   GP
Sbjct: 945  NGVLTGYVLSYHPLD--EGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATT-KEGP 1001

Query: 1811 EIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWS--SGDPGKGPIT---RYVIEARPSD 1865
              EA V  G   G     G+      S+    ++S  S  P +G        + +A   +
Sbjct: 1002 G-EAIVREG---GTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEE 1057

Query: 1866 EGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRV---------IAVNDYGFGTPSSPSQ 1916
            +G   +  + +    SSYT   D L+P   Y+  +         +AV   G G    P  
Sbjct: 1058 KGGASLSPQYVSYNQSSYT-QWD-LQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLP-- 1113

Query: 1917 SVPAQKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGA 1974
              PA     F  E WF+  ++ + L+ ++LL+   I R +  KY+ K        S A
Sbjct: 1114 --PA----GFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEA 1165



 Score =  146 bits (369), Expect = 2e-34
 Identities = 246/1090 (22%), Positives = 416/1090 (38%), Gaps = 117/1090 (10%)

Query: 141  PQPQVTWFRDGRKIPPSSRIAITL-----ENTLVILSTVAPDAGRYYVQAVNDKNGDNKT 195
            P+ Q  W RDG    P   + +T+       +  I    +  A R+  Q +      NK 
Sbjct: 63   PEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF--QGIYRCFASNKL 120

Query: 196  SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIK-LHIIWKKD 254
               ++  +  +   A P  P   + P    V  G S V L C  N  P  + L I W   
Sbjct: 121  GTAMSHEIRLMAEGA-PKWPKETVKP--VEVEEGES-VVLPC--NPPPSAEPLRIYWMNS 174

Query: 255  GVLL----SGGISDHNRRLTIPNPTGSDA-GYYECEA-------VLRSSSVPSVVRGAYL 302
             +L            N  L   N   SD    Y C A       +++   +   V+    
Sbjct: 175  KILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNS 234

Query: 303  SVLEPPQ--FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 360
             +   P+  F      H+ A   + + + C A+G P P+I W + +  +  +++T   Q 
Sbjct: 235  MIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTY--QN 292

Query: 361  NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
            ++  LQ+  +  +D G ++C A N+ G  + + Y+ V + AP     P       G +  
Sbjct: 293  HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEA-APYWLHKPQSHLYGPGETAR 351

Query: 421  LACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATN 479
            L C+  G P+P +TW+  G  +      Q  R   ++ G+L++S    SD     C A N
Sbjct: 352  LDCQVQGRPQPEVTWRINGIPVEELAKDQKYR---IQRGALILSNVQPSDTMVTQCEARN 408

Query: 480  SRGVDEASADL-VVWARTRI-TKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGAT 537
              G+  A+A + VV    +I T   Q    ++G+ A ++C     P  +++++ ++DG T
Sbjct: 409  RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGTT 467

Query: 538  LGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPV 597
            +  +   R     NG+L I    + D G Y C   +   N +  A+L+V+      + P 
Sbjct: 468  VLQDE--RFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP- 524

Query: 598  ATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVP 657
               ST+E++   +T+T     +  L   I    +        L  +          G + 
Sbjct: 525  --RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFIEDGRLV 577

Query: 658  ARSYQFRLCAVNDVGKGQFSKDTE------RVSLPEEPPTAPPQNVIASGR---TNQSIM 708
              S  +     +D G       TE      R  L       P   ++ S     T   + 
Sbjct: 578  IHSLDY-----SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR 632

Query: 709  IQWQPPPESHQNGILKGYIIRYCLAGLPVG--YQFKNITDADVNNLLLEDLIIWTNYEIE 766
            + W P  E H N  ++ Y I +    +     Y    +     +  L   L  + +Y   
Sbjct: 633  VSWSPA-EDH-NAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL--KLSPYVHYTFR 688

Query: 767  VAAYNSAGLGVYSS-KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTW--------NAPSP 817
            V A N  G G  S    T  T +  P   P +V  E   +T +  TW        NAP  
Sbjct: 689  VTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQV 748

Query: 818  QFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF--VSGLKKFTEYFTSVLCFT 875
            Q+          + W P+        T  P  +  +   F  VS    F  Y   V    
Sbjct: 749  QY---------RVQWRPQG-------TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVN 792

Query: 876  TPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTS-LKVSWQ--EPGEKNGILTGYRIS- 931
            + G GP     +  + ED P  +  L   EIL++S + V W+  +  +  G L GY ++ 
Sbjct: 793  SQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTY 852

Query: 932  WEEYNRTNTRVTHY------LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
            W E ++      H       +P  T    ++GL   ++Y +EV A   +G G  S  T S
Sbjct: 853  WREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFS 912

Query: 986  SGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIH 1045
            +  P  +PG P  L +      S+ L+++P       ++ +++      + EG +  L  
Sbjct: 913  T--PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH--PLDEGGKGQLSF 968

Query: 1046 QLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSL 1105
             L  +P+ R+  + DL+P   Y F+++     G             L    D    N+S 
Sbjct: 969  NL-RDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDF--GNIS- 1024

Query: 1106 RTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDL 1165
             TA E    + W+P  E + N     +    K    +  G +LS       +  YT  DL
Sbjct: 1025 ATAGENYSVVSWVP-KEGQCNFRFHIL---FKALGEEKGGASLSPQYVSYNQSSYTQWDL 1080

Query: 1166 EEWTEYRVQV 1175
            +  T+Y + +
Sbjct: 1081 QPDTDYEIHL 1090



 Score =  145 bits (367), Expect = 3e-34
 Identities = 127/495 (25%), Positives = 213/495 (43%), Gaps = 27/495 (5%)

Query: 993  PGPPTNLGISNIG---PRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
            PGP   L +S++       V + + P  D    I ++ +E +   +   E+W   + L  
Sbjct: 612  PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP-EKW---YSLGK 667

Query: 1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
             P  ++     L+P+  Y+FR+  +N  G   PS  S  + T +A P+  P +V      
Sbjct: 668  VPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNE 727

Query: 1110 ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWT 1169
             T++ + W PL  M++N     V Y++++      G     +V D       + +   + 
Sbjct: 728  TTNMVITWKPLRWMDWNA--PQVQYRVQWRPQGTRGPWQEQIVSDPF---LVVSNTSTFV 782

Query: 1170 EYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRN 1229
             Y ++VQA N+ G GP  Q  +G + E  P + P         SS++LV+W  V  A   
Sbjct: 783  PYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVK 842

Query: 1230 GLVLGYKVMYKEKDSDTQ------PRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG 1283
            G + GY V Y  + S  +       +  +V   ++ S  L+GL  Y  Y ++V AF   G
Sbjct: 843  GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902

Query: 1284 DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQIT-HRLNT 1342
             G  S       T + VPG P  +       TS+ L WQPP + NG++  Y ++ H L+ 
Sbjct: 903  SGPASE--FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDE 960

Query: 1343 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQP 1402
                  +  +  P  R +  T L P   Y F++ A T++G GEA      T         
Sbjct: 961  GGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDF 1020

Query: 1403 PSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTI-QTRELPSGRWALHSASVSHNASSF 1461
             +      E+      ++SW P  +G    R++ + +      G  +L    VS+N SS+
Sbjct: 1021 GNISATAGENYS----VVSWVP-KEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSY 1075

Query: 1462 IVDRLKPFTSYKFRV 1476
                L+P T Y+  +
Sbjct: 1076 TQWDLQPDTDYEIHL 1090


>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
            sapiens]
          Length = 1257

 Score =  248 bits (632), Expect = 6e-65
 Identities = 256/1021 (25%), Positives = 419/1021 (41%), Gaps = 68/1021 (6%)

Query: 1    MWGLLIWTLLALHQIRAARAQDDVS--PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEF 58
            +W LL+ +   L QI        V   P    +  R  V    + + L C A G   ++F
Sbjct: 8    VWPLLLCSPCLLIQIPEEYEGHHVMEPPVITEQSPRRLVVFPTDDISLKCEASGKPEVQF 67

Query: 59   KWLHNNRELTKFSLEYRYMITSLDRTHAG-----------------FYRCIVRNRMGALL 101
            +W    R+   F  +    +T     H+G                  YRC   N++G  +
Sbjct: 68   RW---TRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRFQGIYRCFASNKLGTAM 124

Query: 102  QRQTEVQVAYMGSF-EEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDG-RKIPPSSR 159
              +  +       + +E  K   V  GE+ V+      S    ++ W       I    R
Sbjct: 125  SHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDER 184

Query: 160  IAITLENTLVILSTVAPDAGRYYV-QAVNDKNGDNKTSQPITLTVENVGGPADPIAPTII 218
            + +     L   + +  D    Y+  A           +PI L V+      D   P ++
Sbjct: 185  VTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDR-KPRLL 243

Query: 219  IPPKNTS--VVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS--DHNRRLTIPNP 274
             P  ++S  V      + LEC+A   P   +  + +  G + +  ++  +HN+ L +   
Sbjct: 244  FPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWL-RPSGPMPADRVTYQNHNKTLQLLKV 302

Query: 275  TGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKG 334
               D G Y C   L  +S+ S     Y++V   P ++ +P+ H+    E    + CQ +G
Sbjct: 303  GEEDDGEYRC---LAENSLGSARHAYYVTVEAAPYWLHKPQSHLYGPGE-TARLDCQVQG 358

Query: 335  VPPPSITW-YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTST 393
             P P +TW      V E+ K  ++R +  G L +S + P DT + QC ARN  G +  + 
Sbjct: 359  RPQPEVTWRINGIPVEELAKDQKYRIQR-GALILSNVQPSDTMVTQCEARNRHGLLLANA 417

Query: 394  YLAVTSIAPNI-TRGPLDSTVIDGMSVVLACETSGAPRPAITW--QKGERILASGSVQLP 450
            Y+ V  +   I T        + G +  L C+  GAP P++ W  + G  +L     Q  
Sbjct: 418  YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-----QDE 472

Query: 451  RFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKG 510
            RF P  +G+L I     +D G Y CLA N +      A+L V   T+IT+ P+     KG
Sbjct: 473  RFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGPRSTIEKKG 532

Query: 511  TQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCR 570
            ++ +  C  + DP +     W  DG  L            +G L I      D G Y+C 
Sbjct: 533  SRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYSDQGNYSC- 591

Query: 571  VISAGGN--DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE 628
            V S   +  +SR+  L V      P   ++ L  + +  + ++W+   D N+P+ +Y +E
Sbjct: 592  VASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIE 651

Query: 629  MSENN-AP--WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL 685
              +   AP  W   L  V    TS T+K L P   Y FR+ A+N  G G+ S  +E V  
Sbjct: 652  FEDKEMAPEKW-YSLGKVPGNQTSTTLK-LSPYVHYTFRVTAINKYGPGEPSPVSETVVT 709

Query: 686  PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNIT 745
            PE  P   P +V   G    +++I W+P      N     Y +++   G    +Q + ++
Sbjct: 710  PEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQVQYRVQWRPQGTRGPWQEQIVS 769

Query: 746  DADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNS 805
            D     L++ +   +  YEI+V A NS G G        ++ +  P   P     E  NS
Sbjct: 770  DP---FLVVSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNS 826

Query: 806  TTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVG------FVS 859
            + +   W       + G  +GY +  W   +E      + R   +D + V        +S
Sbjct: 827  SAVLVKWRPVDLAQVKGHLRGYNVTYW---REGSQRKHSKRHIHKDHVVVPANTTSVILS 883

Query: 860  GLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPG 919
            GL+ ++ Y   V  F   G GP S      T E VPG    L      +TSL + WQ P 
Sbjct: 884  GLRPYSSYHLEVQAFNGRGSGPAS-EFTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPL 942

Query: 920  EKNGILTGYRISWEEYNRTNT-RVTHYLPNVTLE-YRVTGLTALTTYTIEVAAMTSKGQG 977
              NG+LTGY +S+   +     +++  L +  L  + +T L+    Y  ++ A T +G G
Sbjct: 943  SHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002

Query: 978  Q 978
            +
Sbjct: 1003 E 1003



 Score =  150 bits (378), Expect = 2e-35
 Identities = 161/633 (25%), Positives = 269/633 (42%), Gaps = 70/633 (11%)

Query: 1400 PQPPSRPMVQQEDVRARS-VLLSWEPGSDGLSPVRYYTIQ--TRELPSGRWALHSASVSH 1456
            P P  R ++    +  +S V +SW P  D  +P+  Y I+   +E+   +W        +
Sbjct: 612  PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGN 671

Query: 1457 NASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTT 1516
              S+ +  +L P+  Y FRV A N  G  E S  SE++ T +AAP++ P  +    + TT
Sbjct: 672  QTSTTL--KLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETT 729

Query: 1517 SVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL 1576
            +++I W+P      N   + +R+++R    +G RG            W E       + +
Sbjct: 730  NMVITWKPLRWMDWNAPQVQYRVQWRP---QGTRG-----------PWQE-------QIV 768

Query: 1577 SRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGAT 1636
            S P L    + N +    YEI++   N+ G+GP       + GE  P A P    +    
Sbjct: 769  SDPFLV---VSNTSTFVPYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILN 825

Query: 1637 ATQLDVTWEPPPLDSQNGDIQGYKIYFWE--AQRGNLTERVKTLFLA----ENSVKLKNL 1690
            ++ + V W P  L    G ++GY + +W   +QR +    +    +       SV L  L
Sbjct: 826  SSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGL 885

Query: 1691 TGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFP 1750
              Y++Y + V AFN  G GP S  T   T +  P  P ++     + TS+ + W+ P   
Sbjct: 886  RPYSSYHLEVQAFNGRGSGPASEFT-FSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSH 944

Query: 1751 NGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
            NG+L GY L Y P    +G    ++ +++        + DL+  + YRF+++A T   GP
Sbjct: 945  NGVLTGYVLSYHPLD--EGGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATT-KEGP 1001

Query: 1811 EIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWS--SGDPGKGPIT---RYVIEARPSD 1865
              EA V  G   G     G+      S+    ++S  S  P +G        + +A   +
Sbjct: 1002 G-EAIVREG---GTMALSGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKALGEE 1057

Query: 1866 EGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRV---------IAVNDYGFGTPSSPSQ 1916
            +G   +  + +    SSYT   D L+P   Y+  +         +AV   G G    P  
Sbjct: 1058 KGGASLSPQYVSYNQSSYT-QWD-LQPDTDYEIHLFKERMFRHQMAVKTNGTGRVRLP-- 1113

Query: 1917 SVPAQKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAKKTDSGNSAKSGALG 1976
              PA     F  E WF+  ++ + L+ ++LL+   I R +  KY+ K        S A  
Sbjct: 1114 --PA----GFATEGWFIGFVSAIILLLLVLLILCFIKRSKGGKYSVKDKEDTQVDSEA-- 1165

Query: 1977 HSEMMSLDESSFPALELNNRRLSVKNSFCRKNG 2009
               M       + +LE +N   +  +S    NG
Sbjct: 1166 -RPMKDETFGEYRSLESDNEEKAFGSSQPSLNG 1197



 Score =  146 bits (369), Expect = 2e-34
 Identities = 246/1090 (22%), Positives = 416/1090 (38%), Gaps = 117/1090 (10%)

Query: 141  PQPQVTWFRDGRKIPPSSRIAITL-----ENTLVILSTVAPDAGRYYVQAVNDKNGDNKT 195
            P+ Q  W RDG    P   + +T+       +  I    +  A R+  Q +      NK 
Sbjct: 63   PEVQFRWTRDGVHFKPKEELGVTVYQSPHSGSFTITGNNSNFAQRF--QGIYRCFASNKL 120

Query: 196  SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIK-LHIIWKKD 254
               ++  +  +   A P  P   + P    V  G S V L C  N  P  + L I W   
Sbjct: 121  GTAMSHEIRLMAEGA-PKWPKETVKP--VEVEEGES-VVLPC--NPPPSAEPLRIYWMNS 174

Query: 255  GVLL----SGGISDHNRRLTIPNPTGSDA-GYYECEA-------VLRSSSVPSVVRGAYL 302
             +L            N  L   N   SD    Y C A       +++   +   V+    
Sbjct: 175  KILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNS 234

Query: 303  SVLEPPQ--FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 360
             +   P+  F      H+ A   + + + C A+G P P+I W + +  +  +++T   Q 
Sbjct: 235  MIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTY--QN 292

Query: 361  NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
            ++  LQ+  +  +D G ++C A N+ G  + + Y+ V + AP     P       G +  
Sbjct: 293  HNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVEA-APYWLHKPQSHLYGPGETAR 351

Query: 421  LACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATN 479
            L C+  G P+P +TW+  G  +      Q  R   ++ G+L++S    SD     C A N
Sbjct: 352  LDCQVQGRPQPEVTWRINGIPVEELAKDQKYR---IQRGALILSNVQPSDTMVTQCEARN 408

Query: 480  SRGVDEASADL-VVWARTRI-TKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGAT 537
              G+  A+A + VV    +I T   Q    ++G+ A ++C     P  +++++ ++DG T
Sbjct: 409  RHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL-DEDGTT 467

Query: 538  LGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPV 597
            +  +   R     NG+L I    + D G Y C   +   N +  A+L+V+      + P 
Sbjct: 468  VLQDE--RFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQITQGP- 524

Query: 598  ATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVP 657
               ST+E++   +T+T     +  L   I    +        L  +          G + 
Sbjct: 525  --RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFIEDGRLV 577

Query: 658  ARSYQFRLCAVNDVGKGQFSKDTE------RVSLPEEPPTAPPQNVIASGR---TNQSIM 708
              S  +     +D G       TE      R  L       P   ++ S     T   + 
Sbjct: 578  IHSLDY-----SDQGNYSCVASTELDVVESRAQLLVVGSPGPVPRLVLSDLHLLTQSQVR 632

Query: 709  IQWQPPPESHQNGILKGYIIRYCLAGLPVG--YQFKNITDADVNNLLLEDLIIWTNYEIE 766
            + W P  E H N  ++ Y I +    +     Y    +     +  L   L  + +Y   
Sbjct: 633  VSWSPA-EDH-NAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTL--KLSPYVHYTFR 688

Query: 767  VAAYNSAGLGVYSS-KVTEWTLQGVPTVPPGNVHAEATNSTTIRFTW--------NAPSP 817
            V A N  G G  S    T  T +  P   P +V  E   +T +  TW        NAP  
Sbjct: 689  VTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAPQV 748

Query: 818  QFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF--VSGLKKFTEYFTSVLCFT 875
            Q+          + W P+        T  P  +  +   F  VS    F  Y   V    
Sbjct: 749  QY---------RVQWRPQG-------TRGPWQEQIVSDPFLVVSNTSTFVPYEIKVQAVN 792

Query: 876  TPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTS-LKVSWQ--EPGEKNGILTGYRIS- 931
            + G GP     +  + ED P  +  L   EIL++S + V W+  +  +  G L GY ++ 
Sbjct: 793  SQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVKGHLRGYNVTY 852

Query: 932  WEEYNRTNTRVTHY------LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
            W E ++      H       +P  T    ++GL   ++Y +EV A   +G G  S  T S
Sbjct: 853  WREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASEFTFS 912

Query: 986  SGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIH 1045
            +  P  +PG P  L +      S+ L+++P       ++ +++      + EG +  L  
Sbjct: 913  T--PEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYH--PLDEGGKGQLSF 968

Query: 1046 QLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSL 1105
             L  +P+ R+  + DL+P   Y F+++     G             L    D    N+S 
Sbjct: 969  NL-RDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDF--GNIS- 1024

Query: 1106 RTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDL 1165
             TA E    + W+P  E + N     +    K    +  G +LS       +  YT  DL
Sbjct: 1025 ATAGENYSVVSWVP-KEGQCNFRFHIL---FKALGEEKGGASLSPQYVSYNQSSYTQWDL 1080

Query: 1166 EEWTEYRVQV 1175
            +  T+Y + +
Sbjct: 1081 QPDTDYEIHL 1090



 Score =  145 bits (367), Expect = 3e-34
 Identities = 127/495 (25%), Positives = 213/495 (43%), Gaps = 27/495 (5%)

Query: 993  PGPPTNLGISNIG---PRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
            PGP   L +S++       V + + P  D    I ++ +E +   +   E+W   + L  
Sbjct: 612  PGPVPRLVLSDLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAP-EKW---YSLGK 667

Query: 1050 EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
             P  ++     L+P+  Y+FR+  +N  G   PS  S  + T +A P+  P +V      
Sbjct: 668  VPGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNE 727

Query: 1110 ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWT 1169
             T++ + W PL  M++N     V Y++++      G     +V D       + +   + 
Sbjct: 728  TTNMVITWKPLRWMDWNA--PQVQYRVQWRPQGTRGPWQEQIVSDPF---LVVSNTSTFV 782

Query: 1170 EYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRN 1229
             Y ++VQA N+ G GP  Q  +G + E  P + P         SS++LV+W  V  A   
Sbjct: 783  PYEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEILNSSAVLVKWRPVDLAQVK 842

Query: 1230 GLVLGYKVMYKEKDSDTQ------PRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG 1283
            G + GY V Y  + S  +       +  +V   ++ S  L+GL  Y  Y ++V AF   G
Sbjct: 843  GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902

Query: 1284 DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQIT-HRLNT 1342
             G  S       T + VPG P  +       TS+ L WQPP + NG++  Y ++ H L+ 
Sbjct: 903  SGPASE--FTFSTPEGVPGHPEALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPLDE 960

Query: 1343 TTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQP 1402
                  +  +  P  R +  T L P   Y F++ A T++G GEA      T         
Sbjct: 961  GGKGQLSFNLRDPELRTHNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMALSGISDF 1020

Query: 1403 PSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTI-QTRELPSGRWALHSASVSHNASSF 1461
             +      E+      ++SW P  +G    R++ + +      G  +L    VS+N SS+
Sbjct: 1021 GNISATAGENYS----VVSWVP-KEGQCNFRFHILFKALGEEKGGASLSPQYVSYNQSSY 1075

Query: 1462 IVDRLKPFTSYKFRV 1476
                L+P T Y+  +
Sbjct: 1076 TQWDLQPDTDYEIHL 1090


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  246 bits (629), Expect = 1e-64
 Identities = 395/1726 (22%), Positives = 665/1726 (38%), Gaps = 198/1726 (11%)

Query: 147   WFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203
             W ++G ++P  +R++  ++   + L I     PD G Y V A  DK      S    L +
Sbjct: 12766 WTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDK------SVAELLII 12819

Query: 204   ENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS 263
             E         APT  +       V    +    C  +     K ++ W ++G  +  G  
Sbjct: 12820 E---------APTEFVEHLEDQTVTEFDDAVFSCQLSRE---KANVKWYRNGREIKEGKK 12867

Query: 264   ------DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKE-PER 316
                       RL I +    D   Y C    R S     V    + ++ PPQ + E P  
Sbjct: 12868 YKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGA 12927

Query: 317   HIT--AEMEKVVDIPCQAKGVPPPSITWYKD-AAVVEVEKLTRFRQRNDGGLQISGLVPD 373
              +   AE+ K               + W ++   VV+ +K     +     LQI  + P 
Sbjct: 12928 DVVFLAELNK-----------DKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPR 12976

Query: 374   DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
             D G ++  A++   E +    LA    AP I     D  V  G  + +       P+   
Sbjct: 12977 DQGEYRFIAKDK--EARAKLELAA---APKIKTADQDLVVDVGKPLTMVVPYDAYPKAEA 13031

Query: 434   TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 493
              W K    L++ ++     T  E  S  I      D G Y  +  N  G  E   +L V 
Sbjct: 13032 EWFKENEPLSTKTID----TTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKV- 13086

Query: 494   ARTRITKPPQDQSVIKGTQASMVCG----VTHDPRVTIRYIWEKDGATLGTESHPRIRLD 549
                 +  P ++  V +     +       +T      I Y+ E+      T     +  D
Sbjct: 13087 --IDVPGPVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWV---LATD 13141

Query: 550   RNGSLHISQTWSGDIGT-YTCRV-----ISAGGNDSRSAHLRVRQLPHAPEHPV-ATLST 602
             R  S   + T     G  Y  RV     +  G        +  R     P  P+  T++ 
Sbjct: 13142 RAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD 13201

Query: 603   VERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSY 661
             V R  ++LTW  P +DG + +  Y++E+ +  +       +V  +  S TV  +V  + Y
Sbjct: 13202 VNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEY 13261

Query: 662   QFRLCAVNDVGKGQFSKDTE--RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQ 719
              FR+ A N +G G+ S  T   +V+ P E P+ PP N+ +S +T  S+ ++W+PP +   
Sbjct: 13262 SFRVRAQNRIGVGKPSAATPFVKVADPIERPS-PPVNLTSSDQTQSSVQLKWEPPLKDGG 13320

Query: 720   NGILKGYIIRYCLAGLP--VGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGV 777
             + IL GYII  C  G    +    K + +       LE       Y   V+A N AG+  
Sbjct: 13321 SPIL-GYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEK---GNKYLYRVSAENKAGVSD 13376

Query: 778   YSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQE 837
              S  +   T       P  ++ A       I      P+P  I   + GY          
Sbjct: 13377 PSEILGPLTADDAFVEPTMDLSAFKDGLEVI-----VPNPITILVPSTGYP--------- 13422

Query: 838   EEVTMVTARPNFQDSI-HVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPG 896
                   TA   F D +   G    +K  + Y   V+  +   D    T +L    + + G
Sbjct: 13423 ----RPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISG 13478

Query: 897   PVG-----------HLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNR-TNTRVT 943
              +             L F +I   S+ ++W+ P +  G  LTGY +   E +R T T+V 
Sbjct: 13479 EIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVM 13538

Query: 944   HYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA--STISSGVPPELPGPPTNLGI 1001
              ++ +  LE+ V  L     Y  +V A    G G+ +     ++   P  +P PP N+  
Sbjct: 13539 DFVTD--LEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKW 13596

Query: 1002  SNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARS-MEVP 1059
              +    S+ L + P   DG + I  ++VE         ++W+       EP A + MEV 
Sbjct: 13597 RDRTANSIFLTWDPPKNDGGSRIKGYIVER---CPRGSDKWVAC----GEPVAETKMEVT 13649

Query: 1060  DLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTL--QAPPDM-----APANVSLRTASETS 1112
              L     Y++R++ +N  G S PS+P+ +IQ +  Q  P++       A ++++  ++  
Sbjct: 13650 GLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIE 13709

Query: 1113  LWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER--DYTIEDLEEWTE 1170
             L             G PE    KI ++++D   K    +  + V +    TI D +    
Sbjct: 13710 L--------PATVTGKPEP---KITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDT 13758

Query: 1171  YRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNG 1230
                 ++A N  G      T V           P        T+ S L+ W+  P  D   
Sbjct: 13759 GTYIIEAVNVCGRA----TAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNP-PRDDGGS 13813

Query: 1231  LVLGYKVMYKEKDSDTQPRF-WLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP-S 1288
              +  Y V  +  DS+   +    V+  + ++ +L    +Y+    +V A    G G P  
Sbjct: 13814 KITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIF---RVAAENMYGVGEPVQ 13870

Query: 1289  HPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTA 1348
               PI  +   D PGPP  +   ++   +V L W  P    G  +      RL+  T    
Sbjct: 13871 ASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 13930

Query: 1349  TVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL--VVTTEKRDRPQPPSRP 1406
                 +      Y   GL  +  Y FR+ A+   G G+ +++   ++  +  D P PP +P
Sbjct: 13931 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 13990

Query: 1407  MVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDR 1465
              V  +DV   SV L+W +P  DG + +  Y I+  +  +  W   +  V    +  ++  
Sbjct: 13991 TV--KDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVP--TTQHLLPG 14046

Query: 1466  LKPFTSYKFRVKATNDIGDSEFSEESES-LTTLQAAPDEAPTILSVTPHTTTSVLIRWQP 1524
             L     Y FRV+A N  G+SE SE S+  L   +  P   P  L V   T  +  ++W  
Sbjct: 14047 LMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTV 14106

Query: 1525  PAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQY 1584
             P +D     +  + +  R++  +G               W  + +       +   LT+ 
Sbjct: 14107 PEKDG-GSPITNYIVEKRDVRRKG---------------WQTVDTTVKDTKCTVTPLTEG 14150

Query: 1585  ELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPT--AAPRNVVVHGATATQLDV 1642
              L        Y  R++  NA+G+   +  ++  + +   T    P  + V   T   +D+
Sbjct: 14151 SL--------YVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDL 14202

Query: 1643  TWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAA 1702
              WEPP  D     IQ Y I   E       +  KT    + + ++ ++   T     V A
Sbjct: 14203 KWEPPKNDG-GRPIQRYVIEKKERLGTRWVKAGKTAG-PDCNFRVTDVIEGTEVQFQVRA 14260

Query: 1703  FNAAGDGPRSTPTQ---GQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYR 1758
              N AG G  S PT+    +   + PS P  +  ++     + ++W+ P+   G  + GY 
Sbjct: 14261 ENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYH 14320

Query: 1759  LVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKD-LAEGVTYRFRIRA 1803
             +  E C PV G  K + V+ +    L  KV++ +     Y  R+RA
Sbjct: 14321 V--EMC-PV-GTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRA 14362



 Score =  225 bits (573), Expect = 4e-58
 Identities = 433/1960 (22%), Positives = 731/1960 (37%), Gaps = 276/1960 (14%)

Query: 72    LEYRYMITSLDRTHAGFYRCIVRNRMGAL---------LQRQTEVQVAYMGSFEEGEKHQ 122
             +E ++ ++ L       +R I +N  GA+         +  + EV++  +    +     
Sbjct: 23576 IETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTI 23635

Query: 123   SVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAIT---LENTLVILSTVAPDAG 179
              V+ GE   + A  +   P P + W R  ++I  S+R  I     +  L++   +  D G
Sbjct: 23636 VVNAGETFRLEAD-VHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGG 23694

Query: 180   RYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVA 239
             +Y ++A    N     S P+ + V +  GP          P     V   TSE       
Sbjct: 23695 QYILRA---SNVAGSKSFPVNVKVLDRPGP----------PEGPVQVTGVTSE------- 23734

Query: 240   NARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAG-YYECEAVLRSSSVPSVVR 298
                   K  + W      L  G SD +  +     T   A      E V  S  V  ++ 
Sbjct: 23735 ------KCSLTWSPP---LQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLE 23785

Query: 299   G---AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV------ 349
             G    +  +      V EP       M+    +P   K +   +I   KD+  V      
Sbjct: 23786 GNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIA--KDSMTVCWNRPD 23843

Query: 350   ----------EVEKLTRF---------RQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQ 390
                        VEK  R          R+  D  L+++GL  D    F+  A NAAG  +
Sbjct: 23844 SDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGE 23903

Query: 391   TS-TYLAVTSIAPNITRGP------LDST-----------VIDGMSVVLA-----CETSG 427
              S   +   +  P    GP      +D+T           + DG S +L      C+   
Sbjct: 23904 PSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADE 23963

Query: 428   APRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEA- 486
                  +T Q G R+           T  E   L    T   +     C A N  G+ EA 
Sbjct: 23964 EEWQIVTPQTGLRV-----------TRFEISKL----TEHQEYKIRVC-ALNKVGLGEAT 24007

Query: 487   SADLVVWARTRITKPPQD------QSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540
             S    V    ++  P  D      + ++     S    +    R T    W ++      
Sbjct: 24008 SVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEG---- 24063

Query: 541   ESHPRIRLDRNGS---LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPV 597
             E   ++++++  +   L I      D G Y  ++ ++ G+ S    ++V   P  P++  
Sbjct: 24064 EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQN-- 24121

Query: 598   ATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLV 656
               +  V + +  L W  P  DG + +  Y+++  E+       ++S   K TS  V+ L 
Sbjct: 24122 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSK-TSFKVENLT 24180

Query: 657   PARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPE 716
                 Y FR+ A N+ G G   +  + V   E  P +PP  V  +  +  S  + W+ P  
Sbjct: 24181 EGAIYYFRVMAENEFGVGVPVETVDAVKAAE--PPSPPGKVTLTDVSQTSASLMWEKPEH 24238

Query: 717   SHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLG 776
                + +L GY++     G     ++  + ++ V N ++  L     Y+  V AYN  G  
Sbjct: 24239 DGGSRVL-GYVVEMQPKGTE---KWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKG-- 24292

Query: 777   VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQF-------INGINQGYKL 829
                   ++  + GVP +       + T   +++  +N  S Q        I  I +    
Sbjct: 24293 -----KSDPRVLGVPVIA-----KDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPN 24342

Query: 830   IAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVR 889
             I+W   ++ E    T R N +++     V  +K+  +        T       +T  L  
Sbjct: 24343 ISW--VKDGEPLKQTTRVNVEETA-TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSV 24399

Query: 890   THEDVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHYLP 947
                + PG PVG + F E+    + +SW+ P    G  ++ Y +      R  T  T ++ 
Sbjct: 24400 IVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVE----KRDTTTTTWHMV 24455

Query: 948   NVTL---EYRVTGLTALTTYTIEVAAMTSKGQ-GQVSASTISSGVPPELPGPPTNLGISN 1003
             + T+     ++T L   T Y   + A    G+   + +  +    P + PGPP    +++
Sbjct: 24456 SATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS 24515

Query: 1004  IGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN 1062
             I    + +Q+  P  DG T I  + +E +     E    L +            +   L+
Sbjct: 24516 ISKDQMLVQWHEPVNDGGTKIIGYHLEQK-----EKNSILWVKLNKTPIQDTKFKTTGLD 24570

Query: 1063  PFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPE 1122
                 Y F++   NIVG   PS+ S     +   P   P        +  ++ L+W    +
Sbjct: 24571 EGLEYEFKVSAENIVGIGKPSKVSECF--VARDPCDPPGRPEAIVITRNNVTLKW---KK 24625

Query: 1123  MEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182
               Y+G  +  GY ++  +    G+ +     + +E ++T+  L E   Y  +V A NA G
Sbjct: 24626 PAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 24684

Query: 1183  --SGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSE--VPEADRNGLVLGYKVM 1238
               S P   +     R+ + +    N S        ++V   E  V EAD  G  +   V 
Sbjct: 24685 NFSEPSDSSGAITARDEIDA---PNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVW 24741

Query: 1239  YKE-KDSDTQPRFWLVEGNSSRSAQL------TGLGKYVLYEVQVLAFTRIGDGSPSHPP 1291
              K+ K+ +       ++    ++  +      T  G+Y+L    V        G     P
Sbjct: 24742 SKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV--------GGTKSIP 24793

Query: 1292  ILERTLDDVPGPPMGIL-FPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATV 1350
             I  + LD  PGPP G L    V      L W PP    G  +++ I  +  T+  +   V
Sbjct: 24794 ITVKVLDR-PGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV 24852

Query: 1351  EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTT-EKRDRPQPPSRPMVQ 1409
                   A  Y  T L P + Y+FR+ A  + G GE  E+  VT       P PPS P V 
Sbjct: 24853 ST-EVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVS 24911

Query: 1410  QEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKP 1468
                +   S++++W  P  DG + +  Y ++ R+    RW   +     +     V  L  
Sbjct: 24912 A--ITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDL-RLRVTGLTE 24968

Query: 1469  FTSYKFRVKATNDIGDSEFSEESESLTTLQAA-PDEAPTILSVTPHTTTSVLIRWQPPAE 1527
               SY+FRV A N  G  E SE S       A  P   P+   VT  + +SV + W  P  
Sbjct: 24969 GHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKP-- 25026

Query: 1528  DKINGILLGFRIRYRELLYEG---LRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQY 1584
                              +Y+G   ++G+ +         W   T    ++        Q+
Sbjct: 25027 -----------------IYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQG------KQF 25063

Query: 1585  ELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAVP------TAAPRNVVVHGATA 1637
              +  L ++  Y  R+   N+ G G P++ P  V   E +        A  R VVV  A+A
Sbjct: 25064 TVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASA 25123

Query: 1638  T-QLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE-NSVKLKNLTGYTA 1695
             T +L VT +  P               WE   G LT+R +    +    + + N+T + +
Sbjct: 25124 TLRLFVTIKGRPEPEVK----------WEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDS 25173

Query: 1696  YMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILE 1755
                ++   N +G     T         +PSAP ++   E+   SV +SWE P    G   
Sbjct: 25174 GRYNLTLENNSGS---KTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGA-- 25228

Query: 1756  GYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEAN 1815
               ++        +   K         +    ++++L EG +Y FR+ A    YG  + A 
Sbjct: 25229 --KITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASN-EYGIGLPAE 25285

Query: 1816  VTTGPGEGA--PGPPG-VPIIVRYSSAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDI 1871
              TT P + +  P PPG V ++    +   I W   +  G   IT YV+E +      W  
Sbjct: 25286 -TTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWST 25344

Query: 1872  LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP 1911
                    +V +   ++  L  G  Y FRV AVN+ G   P
Sbjct: 25345 C-----TQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDP 25379



 Score =  218 bits (556), Expect = 4e-56
 Identities = 418/1900 (22%), Positives = 731/1900 (38%), Gaps = 252/1900 (13%)

Query: 136   RIASFPQPQVTWFRDGRKIPPS----------SRIAITLENTLVILSTVAPDAGRYYVQA 185
             +I   P P +TWF+   K P +          +++ +    TLVI  +   D G Y + A
Sbjct: 16139 KIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITA 16198

Query: 186   VNDKNGDNKTSQPITLTVENVGGPADPIAPTII------------IPPKNTSVVAGTSEV 233
             VN+    +K      + +  +G P  P+ P                PPK+      T+ V
Sbjct: 16199 VNNLGTASKE-----MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYV 16253

Query: 234   TLECVANARPLIKLHIIWKKDGVLLSGGISDHNR--RLTIPNPTG-SDAGYYECEAVLRS 290
               +  AN +  + +    K+    +   +  H    R+   N  G  +    E E     
Sbjct: 16254 IEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 16313

Query: 291   SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWY--KDAAV 348
              SVP           + P         +T   E+      +  G  P +  W   KD   
Sbjct: 16314 FSVPGAP--------DKPTVSSVTRNSMTVNWEEP-----EYDGGSPVTGYWLEMKDTTS 16360

Query: 349   VEVEKLTR--FRQRNDG-GLQISGLVPDDTGMFQCFARNAAG----EVQTSTYLAVTSIA 401
                +++ R   +    G   +++GL+      F+ +A NAAG     + +    A   IA
Sbjct: 16361 KRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIA 16420

Query: 402   P---------NITRGPLD----STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQ 448
             P         + T+   D      + DG S V              W+KG+     G+  
Sbjct: 16421 PPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 16480

Query: 449   LPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDE-ASADLVVWARTRITKPP----- 502
             +   T L+ G+             +   A N  G+ E      V+  + R+  P      
Sbjct: 16481 V--VTGLKEGAFY----------KFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDA 16528

Query: 503   --QDQSVIK-GTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQT 559
               +D+ V+  G    ++  V+  P  T+   W  +  TL  E+        + S+ I   
Sbjct: 16529 SVRDRIVVHAGGVIRIIAYVSGKPPPTVT--WNMNERTLPQEATIETTAI-SSSMVIKNC 16585

Query: 560   WSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-G 618
                  G Y+    +  G   ++  + V  +P     P      +   +  LTW  P D G
Sbjct: 16586 QRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLA-HNLTNESCKLTWFSPEDDG 16644

Query: 619   NSPLIRYILEMSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFS 677
              SP+  Y++E  E++   WT +  +V  +  + TV+GL+  ++Y FR+ A N +G G F 
Sbjct: 16645 GSPITNYVIEKRESDRRAWTPVTYTVTRQ--NATVQGLIQGKAYFFRIAAENSIGMGPFV 16702

Query: 678   KDTERVSLPEEPPTAP--PQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGL 735
             + +E + +  EP T P  P+++     T  ++ + W PP   +  G     II Y L   
Sbjct: 16703 ETSEALVI-REPITVPERPEDLEVKEVTKNTVTLTWNPP--KYDGG---SEIINYVLESR 16756

Query: 736   PVGYQ-FKNITDADV--NNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPT 792
              +G + F  +T+ ++      ++ L     YE  V+A N  G G  S      T +    
Sbjct: 16757 LIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKD--E 16814

Query: 793   VPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQ----EEEVTMVTARPN 848
             + P  +H +  +  TIR           +G  +    ++W  ++    E++ T +   P 
Sbjct: 16815 LAPPTLHLDFRDKLTIRVGEAFALTGRYSG--KPKPKVSWFKDEADVLEDDRTHIKTTPA 16872

Query: 849   FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILD 908
                ++ +  +   +  +  +  V+  +T   G R     V   +    PVG +SF E+  
Sbjct: 16873 ---TLALEKIKAKRSDSGKYCVVVENST---GSRKGFCQVNVVDRPGPPVGPVSFDEVTK 16926

Query: 909   TSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTR-VTHYLPNVTLEYRVTGLTALTTYTI 966
               + +SW+ P +  G  +T Y I  +E  +     VT      T   +V+ L     Y  
Sbjct: 16927 DYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTC--KVSKLLEGKDYIF 16984

Query: 967   EVAAMTSKGQGQVSASTISSGVPPE----LPGPPTNLGISNIGPRSVTLQFRPGYDGKTS 1022
              + A    G   +S   +S  +  +    +P  P    ++ +   S  + +   +DG   
Sbjct: 16985 RIHAENLYG---ISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKP 17041

Query: 1023  ISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPP 1082
             I+ +++E +  +    + W  + +    P  +   VPDL     Y FR+   N +G   P
Sbjct: 17042 ITNYILEKRETM---SKRWARVTKDPIHPYTK-FRVPDLLEGCQYEFRVSAENEIGIGDP 17097

Query: 1083  SQPSRKIQTLQ--APPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR 1140
             S PS+ +      A P   P N      +  S+ L W P     ++G  + +GY ++Y +
Sbjct: 17098 SPPSKPVFAKDPIAKPS-PPVNPEAIDTTCNSVDLTWQP---PRHDGGSKILGYIVEYQK 17153

Query: 1141  -SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWS---QTVVGRTRE 1196
               D   +  +H  +   E  Y +  L +   Y+ +V A NA G    +   + V+ + R 
Sbjct: 17154 VGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRL 17213

Query: 1197  SVPS-------SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSD--TQ 1247
               P        +   ++    T   S +++    P           KV +K++D D  T+
Sbjct: 17214 EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFP-----------KVTWKKEDRDAPTK 17262

Query: 1248  PRFWLVEGNSS---RSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1304
              R  +    S    R+A     G Y L          + + + S    ++  + D PGPP
Sbjct: 17263 ARIDVTPVGSKLEIRNAAHEDGGIYSL---------TVENPAGSKTVSVKVLVLDKPGPP 17313

Query: 1305  MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATG 1364
               +   E+R  S  L W+ P    G ++   +  R +  +A  + +   +   + + A  
Sbjct: 17314 RDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKK-KSHFAKH 17372

Query: 1365  LKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPM-VQQEDVRARSVLLSW- 1422
             L   + YLFR+ A+ + G G   E      +  D   PP  P  +   DV    V L W 
Sbjct: 17373 LNEGNQYLFRVAAENQYGRGPFVET-PKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWN 17431

Query: 1423  EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDI 1482
             +P  DG SP+  Y ++ +E  +  W       +      +V  L+   +Y+FRVKA N +
Sbjct: 17432 KPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLEC---VVTGLQQGKTYRFRVKAENIV 17488

Query: 1483  GDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDK----INGILL--G 1536
             G                 PD      +  P      L+   PP+ +     I G+++  G
Sbjct: 17489 G--------------LGLPD------TTIPIECQEKLV---PPSVELDVKLIEGLVVKAG 17525

Query: 1537  FRIRYRELLYEGLRGFTLRGINNPGATWA------ELTSMYSMRNLSRPSLTQYELDNLN 1590
               +R+  ++         RG+  P A W       +    Y++   +  S+    + N  
Sbjct: 17526 TTVRFPAII---------RGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLT--IKNCL 17574

Query: 1591  KHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLD 1650
             +    E +++V NA G    +    V      PT  P N++    T   + ++W+PP  D
Sbjct: 17575 RRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG-PINIL--DVTPEHMTISWQPPK-D 17630

Query: 1651  SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710
                  +  Y +   + ++   T  V +   ++  +K+ +L     Y+  V A N  G GP
Sbjct: 17631 DGGSPVINYIVEKQDTRKD--TWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGP 17688

Query: 1711  R--STPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPV 1767
                STPT  + + + PS P     +++T  +  VSW  P+   G  + GY   Y     V
Sbjct: 17689 PLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGY---YMERREV 17745

Query: 1768  DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT----YGPEIEANVTTGPGEG 1823
              G  K V V+    + L  +V  L EG TY FR+ A+         P  +      P + 
Sbjct: 17746 TG--KWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIK- 17802

Query: 1824  APGPPGVPIIVRYSSAIA-IHWSSG-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
              PGPP  P +   S   A + W+     G  PI  YV+E +      W+ + KD  + + 
Sbjct: 17803 PPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKD--ELIR 17860

Query: 1882  SYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQ 1921
                F +  L  G  Y FR+ A N  G G P   ++SV A+
Sbjct: 17861 QCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAK 17900



 Score =  215 bits (548), Expect = 3e-55
 Identities = 424/1882 (22%), Positives = 697/1882 (37%), Gaps = 278/1882 (14%)

Query: 378   FQCFARNAAG-----EVQTSTYLAVTSIAPNITRGPLDSTVID---GMSVVLACETSGAP 429
             F+  A+N AG     E  +S  +    I P      + + +I    G    +    SG P
Sbjct: 28616 FRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRP 28675

Query: 430   RPAITWQKGE-RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488
              P +TW+  E R+  +  V +   T  +  +L +  +   D+G Y     N+ GV   S 
Sbjct: 28676 APKVTWKLEEMRLKETDRVSIT--TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSV 28733

Query: 489   DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT--IRYIWEK--DGATLGTESHP 544
              +VV  R      P + S +      +  G   D   T    YI EK   G T     + 
Sbjct: 28734 TVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNS 28793

Query: 545   RIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLST-- 602
              ++  +    H+++        Y+ RV S    +       +   P   EHP    S   
Sbjct: 28794 SVKRTQIKVTHLTKYME-----YSFRVSS---ENRFGVSKPLESAPIIAEHPFVPPSAPT 28845

Query: 603   ------VERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGL 655
                   V   A+++ W +P+ DG S +I Y +E  E N    V    V     +  V GL
Sbjct: 28846 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGL 28905

Query: 656   VPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPP 715
             V    YQFR  A+N  G  + S +  R  + + P  AP +  +    T  ++ + W  P 
Sbjct: 28906 VEGLEYQFRTYALNAAGVSKAS-EASRPIMAQNPVDAPGRPEVTDV-TRSTVSLIWSAPA 28963

Query: 716   ESHQNGILKGYII-RYCLAGLPVGYQFK-NITDADVNNLLLEDLIIWTNYEIEVAAYNSA 773
                 + ++ GYII R  ++ +  G   K N T    N   +  L     YE  V A N+A
Sbjct: 28964 YDGGSKVV-GYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAA 29022

Query: 774   GLGVYSSKVTEWTLQGVPTVPP-----GNVHAEATNSTTIRFTWNAPSPQFINGINQGYK 828
             G+    S+ T          PP       +H +     TIR   +      + G  +  K
Sbjct: 29023 GVISKGSESTGPVTCRDEYAPPKAELDARLHGDLV---TIRAGSDLVLDAAVGGKPEP-K 29078

Query: 829   LIAWEPEQE----EEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRST 884
             +I  + ++E    E+V++          I     S   K+T    +         G ++ 
Sbjct: 29079 IIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNA-------SGTKAV 29131

Query: 885   PQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVT 943
               +V+   D PGP G L+ S +      ++W  P E  G  +T Y +   E +R N  + 
Sbjct: 29132 SVMVKVL-DSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIV 29190

Query: 944   HYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG-QVSASTI---SSGVPPELPGPPTNL 999
                   TL Y VT L     Y   V A+   G G  V +  I   +S   P  PG P  +
Sbjct: 29191 EG-ECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEV 29249

Query: 1000  GISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEV 1058
             G    G   + +Q+ +P  DG   IS +LV+ +     +   W  +++     D R ++V
Sbjct: 29250 GT---GKEHIIIQWTKPESDGGNEISNYLVDKREK---KSLRWTRVNKDYVVYDTR-LKV 29302

Query: 1059  PDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAP----PDMAPANVSLRTASETSLW 1114
               L     Y FR+  VN  G S PS+ S  I   +      P  AP  V     S +  W
Sbjct: 29303 TSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAW 29362

Query: 1115  LRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQ 1174
              + M      Y+G  + VGY ++    D       H        ++T+ DL+   +Y  +
Sbjct: 29363 TKPM------YDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFR 29416

Query: 1175  VQAFNAIGSGPWSQTVVGRT---RESVPSSGPTN-----VSALATTSSSMLVRWSEVPEA 1226
             V A N  G   +S+++       R  +P     +     V+  A  S  ++V  S  P  
Sbjct: 29417 VAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPP 29476

Query: 1227  DRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS 1286
                       + + ++  D   R  +   +++ S  L  + K   Y+             
Sbjct: 29477 ---------VITWSKQGIDLASRAII---DTTESYSLLIVDKVNRYDAGKYTIEAENQSG 29524

Query: 1287  PSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTAN 1346
                  +L +  D  PGP   +   EV   SV + W+ P    G  +   I  +       
Sbjct: 29525 KKSATVLVKVYD-TPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRA 29583

Query: 1347  TATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEA--LVVTTEKRDRPQPPS 1404
               TV     S   Y  +GL   ++Y FR+  +   G GE  E    V+ +E    P  P+
Sbjct: 29584 FKTVTTKC-SKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEV---PLVPA 29639

Query: 1405  RPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIV 1463
             +  ++  DV   +V L+WE P  DG S +  Y ++  +  + RW +   ++        V
Sbjct: 29640 K--LEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERW-MKVVTLKPTVLEHTV 29696

Query: 1464  DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-LSVTPHTTTSVLIRW 1522
               L     Y FR++A N+ G SE  E   ++T         PTI LS  P  T  V    
Sbjct: 29697 TSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRV--LPTIDLSTMPQKTIHV---- 29750

Query: 1523  QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582
               PA   +  ++                   + G   P A+W    S   +R   R ++ 
Sbjct: 29751 --PAGRPVELVI------------------PIAGRPPPAASWFFAGS--KLRESERVTVE 29788

Query: 1583  QYELDNLNKHRRYEIRMSVYNAVGE---------GPSSPPQEVFV-GEAVPTAAPRNVVV 1632
              +      K  +  IR +     GE         G +S   +V +  +  P   P  + +
Sbjct: 29789 TH-----TKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP--IKI 29841

Query: 1633  HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG 1692
                 AT + ++WEPP LD     + GY +   +A R       +++    ++ K   LT 
Sbjct: 29842 DEIDATSITISWEPPELDG-GAPLSGYVVEQRDAHRPGWLPVSESV--TRSTFKFTRLTE 29898

Query: 1693  YTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFP 1750
                Y+  VAA N  G G   +S   + ++    P  P +++  +++   + ++W  P+  
Sbjct: 29899 GNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDD 29958

Query: 1751  NGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
              G                 V+  +    +  +  W++V  +   +T   R R+   T G 
Sbjct: 29959 GG---------------SQVTGYIVERKEVRADRWVRVNKVPVTMT---RYRSTGLTEGL 30000

Query: 1811  EIEANVTT--GPGEGAPGPPGVPIIVR-----------------YSSAIAIHWS-SGDPG 1850
             E E  VT     G G P  P  PI+                     +++++ WS   D G
Sbjct: 30001 EYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEG 30060

Query: 1851  KGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGT 1910
                +T Y+IE +  D+  W       P ++  YT +   L  G  Y FRV+A N  G G 
Sbjct: 30061 GSKVTGYLIEMQKVDQHEWT-KCNTTPTKIREYTLTH--LPQGAEYRFRVLACNAGGPGE 30117

Query: 1911  PSSPSQSV--------PAQKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAK 1962
             P+    +V        P  + +  Y+E  F+    ++ L         + I+G+     K
Sbjct: 30118 PAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRL--------TIPIKGKPFPICK 30169

Query: 1963  KTDSGNSAKSGAL-----GHSEMMSLD----ESSFPALELNNRRLSVKNSFCRKNGLYTR 2013
              T  G      A+      H+E++  +    +S    L L N+        C K  +Y +
Sbjct: 30170 WTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENK--------CGKKAVYIK 30221

Query: 2014  SPPRPSPGSLHYSDEDVTKYNDLIPAESSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSF 2073
                  SP     S E   +Y+D I   S  ++ +P   +D  G+D            +  
Sbjct: 30222 VRVIGSPN----SPEGPLEYDD-IQVRSVRVSWRPP--ADDGGADI---------LGYIL 30265

Query: 2074  VNHYISDPTYYNSWRRQQ------KGISRAQAYSYTESDSGEPDHTTVTNSTSTQQGSLF 2127
                 +    +Y    R +      KG+     Y +  S              +  Q  + 
Sbjct: 30266 ERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVS--------------AENQFGIS 30311

Query: 2128  RPKASRTP----TPQNPPNPPS 2145
             +P  S  P    TP NPP PPS
Sbjct: 30312 KPLKSEEPVTPKTPLNPPEPPS 30333



 Score =  213 bits (541), Expect = 2e-54
 Identities = 413/1864 (22%), Positives = 693/1864 (37%), Gaps = 243/1864 (13%)

Query: 147   WFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203
             WFR+   I  SS+  I  ++   TL I      D   Y V   N +  + K++  + +  
Sbjct: 12672 WFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEE 12731

Query: 204   ENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV------L 257
             E++          I+ P K+   +   S VT  C  N    + + + W K+G        
Sbjct: 12732 EDL---------RIVEPLKDIETMEKKS-VTFWCKVNR---LNVTLKWTKNGEEVPFDNR 12778

Query: 258   LSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP-QFVKEPER 316
             +S  +  +   LTI +    D G Y    ++ +    SV   A L ++E P +FV+  E 
Sbjct: 12779 VSYRVDKYKHMLTIKDCGFPDEGEY----IVTAGQDKSV---AELLIIEAPTEFVEHLED 12831

Query: 317   HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQ---ISGLVPD 373
                 E +  V   CQ       ++ WY++    E+++  +++   DG +    I     D
Sbjct: 12832 QTVTEFDDAV-FSCQLSR-EKANVKWYRNGR--EIKEGKKYKFEKDGSIHRLIIKDCRLD 12887

Query: 374   DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
             D   + C   +     +    L V  I   I R P D     G  VV   E +   +  +
Sbjct: 12888 DECEYACGVEDRKSRAR----LFVEEIPVEIIRPPQDILEAPGADVVFLAELN-KDKVEV 12942

Query: 434   TWQKGERILASGSVQLPRFTPLESGS---LLISPTHISDAGTYTCLATNSRGVDEASADL 490
              W +   ++  G     +   +  G    L I      D G Y  +A +     EA A L
Sbjct: 12943 QWLRNNMVVVQGD----KHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK----EARAKL 12994

Query: 491   VVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDR 550
              + A  +I    QD  V  G   +MV  V +D        W K+   L T++        
Sbjct: 12995 ELAAAPKIKTADQDLVVDVGKPLTMV--VPYDAYPKAEAEWFKENEPLSTKTIDTTA--E 13050

Query: 551   NGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVER--RAI 608
               S  I +   GD G Y   + +  G      +L+V  +P     PV  L   E     +
Sbjct: 13051 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPG----PVRNLEVTETFDGEV 13106

Query: 609   NLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPAR-SYQFRLC 666
             +L W +P  DG S +I Y++E  +     T +LA+   ++   TV GL      Y FR+ 
Sbjct: 13107 SLAWEEPLTDGGSKIIGYVVERRDIKRK-TWVLATDRAESCEFTVTGLQKGGVEYLFRVS 13165

Query: 667   AVNDVGKGQ-FSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKG 725
             A N VG G+    D    +  +     PP NV  +      + + W+ PPE      +  
Sbjct: 13166 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWE-PPEYDGGAEITN 13224

Query: 726   YIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEW 785
             Y+I        + +       A+  +  + D++    Y   V A N  G+G   S  T +
Sbjct: 13225 YVIE-LRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVG-KPSAATPF 13282

Query: 786   TLQGVP---TVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTM 842
                  P     PP N+ +     ++++  W  P        + G  ++ +  E+ EE   
Sbjct: 13283 VKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLK------DGGSPILGYIIERCEEGKD 13336

Query: 843   VTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHL 901
                R N +    + + V+GL+K  +Y   V      G         V    ++ GP+   
Sbjct: 13337 NWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAG---------VSDPSEILGPL--T 13385

Query: 902   SFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLE----YRVTG 957
             +    ++ ++ +S  + G +  +     I            T    +  LE     ++  
Sbjct: 13386 ADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKT 13445

Query: 958   LTALTTYTIEVAAMTSKG----QGQVSASTISSGVPPEL---PGPPTNLGISNIGPRSVT 1010
             L+A     I  +  + KG    + +    TIS  +   +   P  P  L   +I   SV 
Sbjct: 13446 LSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVH 13505

Query: 1011  LQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSF 1069
             L +  P  DG + ++ ++VE +       + W  +     + +     VPDL     Y F
Sbjct: 13506 LTWEPPDDDGGSPLTGYVVEKR---EVSRKTWTKVMDFVTDLE---FTVPDLVQGKEYLF 13559

Query: 1070  RMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNG 1127
             ++   N  G   P+     +   T    PD  P NV  R  +  S++L W P    + +G
Sbjct: 13560 KVCARNKCGPGEPAYVDEPVNMSTPATVPD-PPENVKWRDRTANSIFLTWDP---PKNDG 13615

Query: 1128  NPESVGYKIKY--SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG--- 1182
                  GY ++     SD        V + ++E    +  LEE   Y  +V+A N  G   
Sbjct: 13616 GSRIKGYIVERCPRGSDKWVACGEPVAETKME----VTGLEEGKWYAYRVKALNRQGASK 13671

Query: 1183  -SGPWSQTVVGRTRE--------------SVPSSGPTNVSALATTSSSMLVRWSEVPEAD 1227
              S P  +     T+E              +V +     + A  T      + W++     
Sbjct: 13672 PSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKA---- 13727

Query: 1228  RNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 1287
                ++L        ++   +    +V+   S +      G Y++  V V           
Sbjct: 13728 --DMILKQDKRITIENVPKKSTVTIVDSKRSDT------GTYIIEAVNVCG--------- 13770

Query: 1288  SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILA----------YQIT 1337
                 ++E  + D PGPP      +V   S  L W PP    G  +            ++ 
Sbjct: 13771 RATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVW 13830

Query: 1338  HRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKR 1397
             H+L++T  +T            + AT L P   Y+FR+ A+   G GE  +A  +T + +
Sbjct: 13831 HKLSSTVKDT-----------NFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 13879

Query: 1398  -DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVS 1455
              D P PP+R  ++  D+   +V L+W EP  DG SP+  Y ++  +  + +W +    + 
Sbjct: 13880 FDPPGPPTR--LEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKW-VRCNKMP 13936

Query: 1456  HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA----PDEAPTILSVT 1511
                +++ V  L     Y+FRV A N  G  + S+ +E +          P   PT+  V 
Sbjct: 13937 VKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDV- 13995

Query: 1512  PHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMY 1571
                 TSV + W  P  D       G +I            + +  +      W       
Sbjct: 13996 --GKTSVRLNWTKPEHDG------GAKI----------ESYVIEMLKTGTDEW------- 14030

Query: 1572  SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAV-PTAAPRN 1629
              +R       TQ+ L  L + + Y  R+   N  GE  PS P   V   E + P + PR 
Sbjct: 14031 -VRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRW 14089

Query: 1630  VVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKN 1689
             + V   T    D+ W  P  D     I  Y +   + +R    + V T  + +    +  
Sbjct: 14090 LEVINITKNTADLKWTVPEKDG-GSPITNYIVEKRDVRRKG-WQTVDTT-VKDTKCTVTP 14146

Query: 1690  LTGYTAYMVSVAAFNAAGDGPRS---TPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEA 1746
             LT  + Y+  VAA NA G    +        +     P  P ++   ++T   V++ WE 
Sbjct: 14147 LTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEP 14206

Query: 1747  PQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTF 1806
             P+   G     R V E    +   ++ V            +V D+ EG   +F++RA+  
Sbjct: 14207 PKNDGG-RPIQRYVIEKKERLG--TRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENE 14263

Query: 1807  TYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSA----IAIHWSSGDP-GKGPITRYVIEA 1861
                            E    PP  P+ +  + A    IAI W   +  G  PI  Y +E 
Sbjct: 14264 AGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEM 14323

Query: 1862  RPSDEGLWDIL----IKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQS 1917
              P     W  +    IKD+  +V       + + P   Y  RV AVN  G   PS  S++
Sbjct: 14324 CPVGTEKWMRVNSRPIKDLKFKVE------EGVVPDKEYVLRVRAVNAIGVSEPSEISEN 14377

Query: 1918  VPAQ 1921
             V A+
Sbjct: 14378 VVAK 14381



 Score =  213 bits (541), Expect = 2e-54
 Identities = 357/1619 (22%), Positives = 619/1619 (38%), Gaps = 152/1619 (9%)

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQ--TSTYLAVTSI----APNITRGPLDSTVI---DGM 417
             +SGLV D    F+  ARNAAG     + +  A+T+     APN +  P    VI    G 
Sbjct: 24664 VSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGE 24723

Query: 418   SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
             + VL  +  G P P + W K  + L   + ++   + ++  +L++     +D G Y    
Sbjct: 24724 TFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKL 24783

Query: 478   TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT------IRYIW 531
             +N  G       + V  R     PP+    + G  A   C +  +P +         YI 
Sbjct: 24784 SNVGGTKSIPITVKVLDRPG---PPEGPLKVTGVTAEK-CYLAWNPPLQDGGANISHYII 24839

Query: 532   EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG----GNDSRSAHLRVR 587
             EK   +  + +     +    +L+   T       Y  RV++      G    S  +   
Sbjct: 24840 EKRETSRLSWTQVSTEVQ---ALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTAC 24896

Query: 588   QLPHAPEHPVAT--LSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLASVD 644
               P+ P  P +T  +S + + ++ +TW +P D G + +  YILE  +             
Sbjct: 24897 N-PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKT 24955

Query: 645   PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP-PTAPPQNVIASGRT 703
                  + V GL    SY+FR+ A N  G G+ S+ +      +   P  PP N   +  +
Sbjct: 24956 LTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTS 25015

Query: 704   NQSIMIQWQPPPESHQNGI-LKGYIIRYCLAGL--------PVGYQFKNITDADVNNLLL 754
               S+ + W  P   +  G  +KGY++    A          P G Q K  T   +     
Sbjct: 25016 RSSVSLAWSKP--IYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKEN-- 25071

Query: 755   EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNA 814
                   T Y   + A NS G+G  ++       Q    + P  +  +A     +    +A
Sbjct: 25072 ------TEYNFRICAINSEGVGEPATLPGSVVAQ--ERIEPPEIELDADLRKVVVLRASA 25123

Query: 815   PSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCF 874
                 F+    +    + WE  + E +    A+     S  +  +  + +F     ++   
Sbjct: 25124 TLRLFVTIKGRPEPEVKWE--KAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLE 25181

Query: 875   TTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWE 933
                G   ++    VR  +    PV +L+  E+   S+ +SW+ P    G  +T Y +   
Sbjct: 25182 NNSGS--KTAFVNVRVLDSPSAPV-NLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKR 25238

Query: 934   EYNR-TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992
             E  R     +T+     T  +R+  L    +Y   V A    G G + A T       E 
Sbjct: 25239 ETTRKAYATITNNCTKTT--FRIENLQEGCSYYFRVLASNEYGIG-LPAETTEPVKVSEP 25295

Query: 993   PGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
             P PP  + + ++   + T+++ +P  DG + I+ ++VE Q       E+W    Q+    
Sbjct: 25296 PLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTK---GSEKWSTCTQVKT-- 25350

Query: 1052  DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPANVSLRTAS 1109
                   +  L     Y FR+  VN  G S P Q    +  + ++  P +     +    +
Sbjct: 25351 --LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKA 25408

Query: 1110  ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWT 1169
                L +      ++ + G P++    + + +    G+TL    +  V    T+  L    
Sbjct: 25409 REQLKI------DVPFKGRPQAT---VNWRKD---GQTLKETTRVNVSSSKTVTSLSIKE 25456

Query: 1170  EYRVQVQAF-----NAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVP 1224
               +  V  +     N+ GS     T++   R   P  GP  +  ++    S+ + W+  P
Sbjct: 25457 ASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPP--GPIRIDEVSC--DSITISWNP-P 25511

Query: 1225  EADRNGLVLGYKVMYKEKDSDTQPRFWLV--EGNSSRSAQLTGLGKYVLYEVQVLAFTRI 1282
             E D    +  Y V  KE  S T    W +  +  +  S ++  L     Y+ +V A  R 
Sbjct: 25512 EYDGGCQISNYIVEKKETTSTT----WHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRY 25567

Query: 1283  GDGSPSHPP-ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQITHRL 1340
             G  S S    ++       PGPP          +++ + WQ P    G  ++ Y + ++ 
Sbjct: 25568 GKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKE 25627

Query: 1341  NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRP 1400
              ++   +   ++L     Q   +GL    +Y +R+ A+   G G+ +++       RD  
Sbjct: 25628 RSSILWSKANKILIADT-QMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE-PVPARDPC 25685

Query: 1401  QPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNAS 1459
              PP +P V   ++  +SV L W +P  DG + +  Y ++ RELP GRW L     +   +
Sbjct: 25686 DPPGQPEVT--NITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRW-LKCNYTNIQET 25742

Query: 1460  SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVL 1519
              F V  L     Y+FRV A N       SE SES   +    D  P  + +       ++
Sbjct: 25743 YFEVTELTEDQRYEFRVFARN--AADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIV 25800

Query: 1520  IRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRP 1579
             ++       KIN  + G   R   ++     G  +           +  ++ ++++  R 
Sbjct: 25801 VKAGEVL--KINADIAG---RPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRR 25855

Query: 1580  SLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQ 1639
                QY L   N      + ++       GP + P E+                +G TA +
Sbjct: 25856 DTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEI----------------NGLTAEK 25899

Query: 1640  LDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVS 1699
               ++W  P  D    DI  Y +   + +  +L   +    L   S K+  L     Y+  
Sbjct: 25900 CSLSWGRPQEDG-GADIDYYIVE--KRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFR 25956

Query: 1700  VAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEG 1756
             V   N  G G    S   +       PS P+S++ + +T  S+ + W  P+   G  + G
Sbjct: 25957 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISG 26016

Query: 1757  YRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT---FTYGPEIE 1813
             Y +     + +    + V V+ K    L +K   L EG  Y +R+ A+     +   E  
Sbjct: 26017 YIIERREKNSL----RWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETS 26072

Query: 1814  ANVTTGPGEGAPGPPGVPIIVRYS-SAIAIHWSSG-DPGKGPITRYVIEARPSDEGLWDI 1871
               +        P PP  P IV    + I I W      G  PIT Y +E + SD+  W  
Sbjct: 26073 PLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKT 26132

Query: 1872  LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPS--QSVPAQKANPFYE 1928
              I+ +    + YT S   L  G  Y FRV +VN  G   PS  S  Q    ++  P ++
Sbjct: 26133 SIQSL--RGTEYTISG--LTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFD 26187



 Score =  211 bits (538), Expect = 5e-54
 Identities = 373/1635 (22%), Positives = 612/1635 (37%), Gaps = 185/1635 (11%)

Query: 361   NDGGLQISGLVPDDTGMFQCFARNAAGEVQ-----TSTYLAVTSIAPNITRGPLDS---- 411
             +D    ++ L   DT  F+  A+NAAG +      T         AP   +  LD+    
Sbjct: 28997 SDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAP--PKAELDARLHG 29054

Query: 412   ---TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS 468
                T+  G  +VL     G P P I W KG++ L        ++T  +  + +I     S
Sbjct: 29055 DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTG-KRATAVIKFCDRS 29113

Query: 469   DAGTYTCLATNSRGVDEASADLVVW------ARTRITKPPQDQSVIKGT--QASMVCGVT 520
             D+G YT    N+ G    S  + V        +  +++  Q++  +  +  Q      +T
Sbjct: 29114 DSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEIT 29173

Query: 521   H---DPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG-- 575
             H   + R T R  W        T S+   RL +N               Y  RV +    
Sbjct: 29174 HYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNE-------------YIFRVRAVNKY 29220

Query: 576   --GNDSRSAHLRVRQ---LPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEM 629
               G    S  +  R    +P  P  P    +  E   I + WTKP  DG + +  Y+++ 
Sbjct: 29221 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEH--IIIQWTKPESDGGNEISNYLVDK 29278

Query: 630   SENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEE 688
              E  +  WT +        T + V  L+    YQFR+ AVN  G  + S+ +  +S  E 
Sbjct: 29279 REKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREP 29338

Query: 689   PPT-APPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDA 747
               T  PP        T  SI + W  P       I+ GY++          Y+    T+A
Sbjct: 29339 SYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIV-GYVLEMQEKDTDQWYRVH--TNA 29395

Query: 748   DVNN--LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNS 805
              + N    + DL +   Y   VAA N  G+  YS  + E        +P   +  +   +
Sbjct: 29396 TIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKT 29455

Query: 806   TTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFT 865
              TIR    A     ++   +   +I W  +  +  +          S+ +     + K  
Sbjct: 29456 VTIRA--GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLI-----VDKVN 29508

Query: 866   EYFTSVLCFTTPGD-GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI 924
              Y             G +S   LV+ + D PGP   +   E+   S+ ++W+ P    G 
Sbjct: 29509 RYDAGKYTIEAENQSGKKSATVLVKVY-DTPGPCPSVKVKEVSRDSVTITWEIPTIDGGA 29567

Query: 925   -LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAST 983
              +  Y +   E      +      + TL YR++GL   T Y   V      G G+    T
Sbjct: 29568 PVNNYIVEKREAAMRAFKTVTTKCSKTL-YRISGLVEGTMYYFRVLPENIYGIGE-PCET 29625

Query: 984   ISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEA-QVGVVGEGEEW 1041
               + +  E+P  P  L + ++   +VTL + +P YDG + ++ +++EA + G     E W
Sbjct: 29626 SDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGT----ERW 29681

Query: 1042  LLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP--SRKIQTLQAPPDMA 1099
             + +  L  +P      V  LN    Y FR+R  N  G S P +   +  +Q L+  P + 
Sbjct: 29682 MKVVTL--KPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTID 29739

Query: 1100  PANVSLRTAS-------ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRS---DGHGKTLS 1149
              + +  +T         E  + +   P P   +       G K++ S     + H K   
Sbjct: 29740 LSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWF----FAGSKLRESERVTVETHTKVAK 29795

Query: 1150  HVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSAL 1209
               +     R+ TI D  E+T     ++  N  G+   +  V+   +   P +GP  +  +
Sbjct: 29796 LTI-----RETTIRDTGEYT-----LELKNVTGTTSETIKVIILDKPG-PPTGPIKIDEI 29844

Query: 1210  ATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGK 1268
               TS  + + W E PE D    + GY V   E+    +P +  V  + +RS  + T L +
Sbjct: 29845 DATS--ITISW-EPPELDGGAPLSGYVV---EQRDAHRPGWLPVSESVTRSTFKFTRLTE 29898

Query: 1269  YVLYEVQVLAFTRIGDGSPSHPPILE-RTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAP 1327
                Y  +V A  R G GS     ++E R+   +PGPP  +   +V    + L W PP   
Sbjct: 29899 GNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDD 29958

Query: 1328  NGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAA 1387
              G  +   I  R          V  +  +  +Y +TGL     Y  R+TA   +G G+ +
Sbjct: 29959 GGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPS 30018

Query: 1388  EAL--VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPS 1444
                  +V  +    P  P  P V   D    SV L+W  P  +G S V  Y I+ +++  
Sbjct: 30019 RPSKPIVAMDPIAPPGKPQNPRV--TDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQ 30076

Query: 1445  GRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA 1504
               W   + + +     + +  L     Y+FRV A N  G  E              P E 
Sbjct: 30077 HEWTKCNTTPT-KIREYTLTHLPQGAEYRFRVLACNAGGPGE--------------PAEV 30121

Query: 1505  PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRG-----FTLRGINN 1559
             P  + VT       ++ +     D+          RY+E ++    G       ++G   
Sbjct: 30122 PGTVKVTE------MLEYPDYELDE----------RYQEGIFVRQGGVIRLTIPIKGKPF 30165

Query: 1560  PGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVG 1619
             P   W +     S R +   S T  EL      R        Y+ V E      + V++ 
Sbjct: 30166 PICKWTKEGQDISKRAMIATSETHTELVIKEADRG---DSGTYDLVLENKCG-KKAVYIK 30221

Query: 1620  EAV---PTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRG---NLTE 1673
               V   P +    +         + V+W  PP D    DI GY +   E  +     +  
Sbjct: 30222 VRVIGSPNSPEGPLEYDDIQVRSVRVSWR-PPADDGGADILGYILERREVPKAAWYTIDS 30280

Query: 1674  RVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDG---PRSTPTQGQTQQAAPSAPSS- 1729
             RV+       S+ +K L     Y   V+A N  G         P   +T    P  PS+ 
Sbjct: 30281 RVR-----GTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNP 30335

Query: 1730  VKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKV 1788
              +  ++T +SV++SW  P+   G  + GY +  +  S      K V  +    +     V
Sbjct: 30336 PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETS----TDKWVRHNKTQITTTMYTV 30391

Query: 1789  KDLAEGVTYRFRIRAKT----FTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHW 1844
               L     Y+FRI A+         P  E  V   P +    P  + I+     ++ + W
Sbjct: 30392 TGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQW 30451

Query: 1845  SSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAV 1903
                +  G   I  Y +E R S +  W    K   + +    F++  L     Y+FRV A 
Sbjct: 30452 EKPECDGGKEILGYWVEYRQSGDSAWK---KSNKERIKDKQFTIGGLLEATEYEFRVFAE 30508

Query: 1904  NDYGFGTPSSPSQSV 1918
             N+ G   P   + S+
Sbjct: 30509 NETGLSRPRRTAMSI 30523



 Score =  211 bits (537), Expect = 6e-54
 Identities = 408/1878 (21%), Positives = 683/1878 (36%), Gaps = 218/1878 (11%)

Query: 136   RIASFPQPQVTWFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVNDKNGD 192
             R+   P+P +TW ++G+ +    R+ +  +     L I   V  D G+Y + A   KN  
Sbjct: 17931 RVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISA---KNSS 17987

Query: 193   NKTSQPITLTVENVGGPADPIAPTIIIPPKNT-----SVVAGTSEVTLECVANARPLIKL 247
                     + V +  GP   +  T +     T      +  G SE+T   V   +P  K 
Sbjct: 17988 GHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQK- 18046

Query: 248   HIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEP 307
                W       S   SD  +RL   N   ++  Y+   A  +    P++     +  + P
Sbjct: 18047 --GW-------SIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINP 18097

Query: 308   PQFVKEPER-HITAEMEKVVDIPCQAKGVP--PPSITWYKDAAVVEVEKLTRFRQRN--D 362
                  EPE  HI  + +  V +  +        P+++++ +  +   +   R  + +  +
Sbjct: 18098 IDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKE 18157

Query: 363   GGLQISGLVPDDTGMFQCFARNAAGE---VQTSTYLAVTSIAPNITRGPLDS--TVIDGM 417
                 +   V +    F+   +N  GE   V+T   +    +   +    L    TV  G 
Sbjct: 18158 THYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGD 18217

Query: 418   SVVLACETSGAPRPAITWQKGERILASGSVQLPRF---TPLESGSLLISPTHISDAGTYT 474
             ++ L     G P P + W K +   A+   + PR    T  +S    ++    SD G Y 
Sbjct: 18218 TIRLEAGVRGKPFPEVAWTKDKD--ATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 18275

Query: 475   CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR---------- 524
               ATN+ G   A A + V     + KP   +++     +S  C V  DP           
Sbjct: 18276 VTATNTAGSFVAYATVNV-----LDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQN 18330

Query: 525   ------VTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGND 578
                    T R +W    AT+ T      RL               IGT           +
Sbjct: 18331 YILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGT-------GPPTE 18383

Query: 579   SRSAHLRVR-QLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP- 635
             S+    + +   P  P+ P  T   V +  + + W  P +DG   +  Y LE  E ++  
Sbjct: 18384 SKPVIAKTKYDKPGRPDPPEVT--KVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTR 18441

Query: 636   WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL--PEEPPTAP 693
             W  +  S  P+   + V+ L+P   YQFR+ A N++G G+ S  +  V    P EPP  P
Sbjct: 18442 WVPVNKSAIPE-RRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPP-GP 18499

Query: 694   PQNVIASGRTNQSIMIQWQPPPESHQNGILKGYII---------------RYCLAGLPVG 738
             P N      T  SI + W  P       I+ GY++               + C A   + 
Sbjct: 18500 PTNFRVVDTTKHSITLGWGKPVYDGGAPII-GYVVEMRPKIADASPDEGWKRCNAAAQLV 18558

Query: 739   YQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNV 798
              +   +T  D N            YE  V A N  G+G   +++ E  ++    + P  +
Sbjct: 18559 RKEFTVTSLDENQ----------EYEFRVCAQNQVGIG-RPAELKE-AIKPKEILEPPEI 18606

Query: 799   HAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFV 858
               +A+    +      P   F     +    + W     + V     R    D +     
Sbjct: 18607 DLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNV----VRKGQVDLVDTMAF 18662

Query: 859   SGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEP 918
               +   T   +     T           +     D PGPV  L  S++  TS  VSW  P
Sbjct: 18663 LVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPP 18722

Query: 919   GEKNGI-LTGYRISWEEYNR-TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQ 976
                 G  +T Y +   E +R T + VT  +   +  + VT L     Y   V A+   G 
Sbjct: 18723 ENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTS--FHVTNLVPGNEYYFRVTAVNEYGP 18780

Query: 977   GQVS--ASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKTSISRWLV--EAQ 1031
             G  +     + +  P   P PP  L ++ +   S TL + P   DG   I  ++     +
Sbjct: 18781 GVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREE 18840

Query: 1032  VGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPS---RK 1088
                     E+ ++  L       S+ V  L     Y FR+   N VG S P +       
Sbjct: 18841 EQPADRWTEYSVVKDL-------SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA 18893

Query: 1089  IQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL 1148
              + L  P  + P  ++++   +  +        E    G P       K+ + +    T 
Sbjct: 18894 KEQLLPPKILMPEQITIKAGKKLRI--------EAHVYGKPHPT---CKWKKGEDEVVTS 18942

Query: 1149  SHVVQDRVERD--YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNV 1206
             SH+   + +      I+D+         + A N+ G+      VV       P   P ++
Sbjct: 18943 SHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPG-PPQPPFDI 19001

Query: 1207  SALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWL-----VEGNSSRSA 1261
             S +   + S+   W  +P  D    +  Y V    +  D     W+     V   S R  
Sbjct: 19002 SDIDADACSL--SW-HIPLEDGGSNITNYIV----EKCDVSRGDWVTALASVTKTSCRVG 19054

Query: 1262  QLTGLGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLI 1320
             +L    +Y+    +V A  R G   P + P ++ +    VP  P      +V    + + 
Sbjct: 19055 KLIPGQEYIF---RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVA 19111

Query: 1321  WQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQT 1379
             W  P +  G  I+ Y I  +   +       + L  S  +Y   GL     Y FRI A  
Sbjct: 19112 WDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRST-EYPCAGLVEGLEYSFRIYALN 19170

Query: 1380  RKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQ 1438
             + G    ++     T  R    PP +P V   DV   +V L W  P  DG S +  Y ++
Sbjct: 19171 KAGSSPPSKPTEYVT-ARMPVDPPGKPEV--IDVTKSTVSLIWARPKHDGGSKIIGYFVE 19227

Query: 1439  TRELPSGRWA-LHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTL 1497
               +LP  +W   ++A        +    L+    Y+FR  A   +  S  SE S+ +T L
Sbjct: 19228 ACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 19287

Query: 1498  QAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGI 1557
                        +V P    SV ++     +   N  L                  T+ G 
Sbjct: 19288 AE---------NVPPRIDLSVAMKSLLTVKAGTNVCL----------------DATVFGK 19322

Query: 1558  NNPGATWAE----LTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPP 1613
               P  +W +    L     ++   + +L   EL ++N+    +  ++  N+ G   ++  
Sbjct: 19323 PMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIK 19382

Query: 1614  QEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTE 1673
              +V          P +V ++   + +  ++WE PPL+    +I  Y +   E  R N  +
Sbjct: 19383 LKVL----DKPGPPASVKINKMYSDRAMLSWE-PPLEDGGSEITNYIVDKRETSRPNWAQ 19437

Query: 1674  RVKTLFLAENSVKLKNLTGYTAYMVSVAAFN--AAGDGPRSTPTQGQTQQAAPSAPSSVK 1731
                T+ +   SV+ K + G+  Y   + A N    GD   + P   +     P       
Sbjct: 19438 VSATVPITSCSVE-KLIEGH-EYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPV 19495

Query: 1732  FSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKD 1790
              S +T   + VSW+ P    G  + GY L       V+       V+ K      LK   
Sbjct: 19496 ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTK----VNRKPIIERTLKATG 19551

Query: 1791  LAEGVTYRFRIRAKTFTYGPEIEANVTTG----PGEGAPGPPGVPIIVRYS-SAIAIHWS 1845
             L EG  Y FR+ A     GP   ++ +        +  PGPP  P +   + S++++ W 
Sbjct: 19552 LQEGTEYEFRVTAIN-KAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSW- 19609

Query: 1846  SGDP---GKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
              G P   G  PI  Y++E + +D   W  +  ++P+ +    F +  L     Y FRV A
Sbjct: 19610 -GKPAYDGGSPIIGYLVEVKRADSDNW--VRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 19666

Query: 1903  VNDYGFGTPSS-PSQSVP 1919
             VN  G+  PS  P +  P
Sbjct: 19667 VNKIGYSDPSDVPDKHYP 19684



 Score =  211 bits (537), Expect = 6e-54
 Identities = 342/1451 (23%), Positives = 555/1451 (38%), Gaps = 168/1451 (11%)

Query: 531   WEKDGATLGTESHPRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
             W K G  +      +I      S L I      D G YT    +  G       + V  +
Sbjct: 20413 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDV 20472

Query: 590   PHAPEHPVATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAP-WTVLLASVDPKA 647
             P  P  PV  +S V      LTWT P  DG SP+  YILE  E +   WTV+  S D ++
Sbjct: 20473 P-GPPGPVE-ISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVV--SEDIQS 20528

Query: 648   TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSI 707
                    L+    Y FR+ AVN  GKG+  +      +    P  PP+    S  T  + 
Sbjct: 20529 CRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTA 20588

Query: 708   MIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKN-ITDADVNNLLLEDLIIWTNYEIE 766
              + W+ P +   + I   ++ R     L      K  ++D       L++    + YE  
Sbjct: 20589 TVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQE---GSTYEFR 20645

Query: 767   VAAYNSAGLGVYSSKVTEWTLQGV--PTVPPGNVHAEATNSTTIRFTWNAPSPQFINGIN 824
             V+A N AG+G  S       ++    P  PP N H   T   +    W  P        +
Sbjct: 20646 VSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPH------YD 20699

Query: 825   QGYKLIAWEPEQEEEVTMVTARPNFQDSIHVG--FVSGLKKFTEYFTSVLCFTTPGDGPR 882
              G ++  +  E ++       +     ++ +    V  L+   +Y   +      G G  
Sbjct: 20700 GGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEP 20759

Query: 883   STPQLVRTHEDVPGPVGHLSFSEILDT-------SLKVSWQEPGEKNGILTGYRISWEEY 935
             +    V   E    P   L  +E+  T       S+++     G     +T  + +    
Sbjct: 20760 AVIPDVEIVEREMAPDFELD-AELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLK 20818

Query: 936   NRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP 995
             NR N   T     + +       T     TIE  A   K  G V+   + +      PGP
Sbjct: 20819 NRANIENTESFTLLIIPECNRYDTGKFVMTIENPA--GKKSGFVNVRVLDT------PGP 20870

Query: 996   PTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDAR 1054
               NL  ++I   SVTL +  P  DG + I+ ++VE +                + +    
Sbjct: 20871 VLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS------YSTATTKCHKC 20924

Query: 1055  SMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLW 1114
             + +V  L+    Y FR+   N  G   P++ +  ++  +AP    P ++++   +++++ 
Sbjct: 20925 TYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PDSLNIMDITKSTVS 20982

Query: 1115  LRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQ 1174
             L W   P+ +++G  +  GY I+  R      T    V+     +  + +L E  EY  Q
Sbjct: 20983 LAW---PKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGL---ECVVRNLTEGEEYTFQ 21036

Query: 1175  VQAFNAIG-SGPW-SQTVVGRTRESVPS---SGPTNVSALATTSSSMLVRWSEVPEADRN 1229
             V A N+ G S P  S+ V+ + +  +P     G      +A    ++ V   E+P   R 
Sbjct: 21037 VMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKV---EIPVLGRP 21093

Query: 1230  GLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFT------RIG 1283
                + +K     K      +   V   ++ ++ +  + + V  +      T       +G
Sbjct: 21094 KPTVTWK-----KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVG 21148

Query: 1284  DGSPSHPPILERTLDDVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNT 1342
             D       ++   + D+PGPP G I F EV +  V   W PP    G+ ++  +     T
Sbjct: 21149 D-------VITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQT 21201

Query: 1343  TTANTATVEVLAPSARQ-YTATGLKPESVYLFRITAQTRKGWGEA-AEALVVTTEKRDRP 1400
              +  T  VE+     R  Y AT L     Y FR+ AQ R G G     A +V       P
Sbjct: 21202 DS--TTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVP 21259

Query: 1401  QPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRW-ALHSASVSHNA 1458
              PP  P V    V   S+ +SW EP SDG SP+  Y ++ +E     W  +  A V  N 
Sbjct: 21260 GPPGTPQVTA--VTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 21317

Query: 1459  --SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA-PDEAPTILSVTPHTT 1515
               SS + D +    +Y+FRV A N  G S+ S+ SE +  L    P   P  L++T HT 
Sbjct: 21318 FKSSGLTDGI----AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTV 21373

Query: 1516  TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
             T   ++W  P   +  G   GF+I            + +   + P   W +        N
Sbjct: 21374 T---LKWAKP---EYTG---GFKIT----------SYIVEKRDLPNGRWLKA-------N 21407

Query: 1576  LSRPSLTQYELDNLNKHRRYEIRMSVYNAVG--EGPSSPPQEVFVGEAVPTAAPR----- 1628
              S     ++ +  L +   YE R+   NA G    PS P   +   + V   AP+     
Sbjct: 21408 FSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVE--APKIKVDV 21465

Query: 1629  ----NVVVHGATATQL--DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
                  V++    A +L  DV+  PPP    + D         +   G     +K    + 
Sbjct: 21466 KFKDTVILKAGEAFRLEADVSGRPPPTMEWSKD--------GKELEGTAKLEIKIADFST 21517

Query: 1683  NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
             N V  K+ T   +   ++ A N  G        +   +   P  P +V  +E+T+    +
Sbjct: 21518 NLVN-KDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAV--TEVTSEKCVL 21574

Query: 1743  SWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLW-LKVKDLAEGVTYRFRI 1801
             SW  P    G    + +V +        S++   +V     +  LKV  L +G  Y FR+
Sbjct: 21575 SWFPPLDDGGAKIDHYIVQKR-----ETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRV 21629

Query: 1802  RA-KTFTYGPEIEANVTTGPGE-GAPGPPGVPIIVRYSS-AIAIHWSSGDP-GKGPITRY 1857
              A   +  G  +E+         G P PP  P +   +  ++ + W   D  G   I  Y
Sbjct: 21630 MAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINY 21689

Query: 1858  VIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQS 1917
             ++E R      W   IK   K ++   + +  L  G  Y+FR++A N  G   PS  S  
Sbjct: 21690 IVERRDKAGQRW---IKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTS-- 21744

Query: 1918  VPAQKANPFYE 1928
                    PFY+
Sbjct: 21745 -------PFYK 21748



 Score =  211 bits (537), Expect = 6e-54
 Identities = 438/1934 (22%), Positives = 700/1934 (36%), Gaps = 355/1934 (18%)

Query: 141   PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRY----YVQAVNDKNGDNKTS 196
             P P+VTW +D   +   + I  T   TL+I+    P+  RY    +V  + +  G  K S
Sbjct: 20804 PAPEVTWTKDNINLKNRANIENTESFTLLII----PECNRYDTGKFVMTIENPAG--KKS 20857

Query: 197   QPITLTVENVGGPADPIAPTIIIPPKNT-----SVVAGTSEVTLECVANARPLIKLHIIW 251
               + + V +  GP   + PT I     T      ++ G S +T             +I+ 
Sbjct: 20858 GFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRIT------------NYIVE 20905

Query: 252   KKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311
             K++    S   +           TG   G   CE   R  +      G      EP   V
Sbjct: 20906 KREATRKSYSTATTKCHKCTYKVTGLSEG---CEYFFRVMAENEYGIGEPTETTEP---V 20959

Query: 312   KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLV 371
             K  E     +   ++DI          S+ W K               ++DGG +I+G V
Sbjct: 20960 KASEAPSPPDSLNIMDITKST-----VSLAWPK--------------PKHDGGSKITGYV 21000

Query: 372   PD-------------DTGMFQCFARN-AAGEVQTSTYLAVTS------------------ 399
              +                  +C  RN   GE  T   +AV S                  
Sbjct: 21001 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQT 21060

Query: 400   IAPNI-TRGPLDSTVI--DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLE 456
             + P +  RG     VI   G ++ +     G P+P +TW+KG++IL     Q   F    
Sbjct: 21061 MLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILK--QTQRVNFETTA 21118

Query: 457   SGSLL-ISPTHISDAGTYTCLATNSRG----------------------VDEASADLVVW 493
             + ++L I+    SD+G Y   A N  G                       DE S+D V +
Sbjct: 21119 TSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTF 21178

Query: 494   ARTRITKPPQDQS-------VIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRI 546
             +      PP++         V++  Q      V     V IR  ++    T G E   R+
Sbjct: 21179 S----WDPPENDGGVPISNYVVEMRQTDSTTWVELATTV-IRTTYKATRLTTGLEYQFRV 21233

Query: 547   RLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERR 606
             +      +    T +  +  Y  +V                  P  P  P  T   V + 
Sbjct: 21234 KAQNRYGVGPGITSACIVANYPFKV------------------PGPPGTPQVT--AVTKD 21273

Query: 607   AINLTWTKPF-DGNSPLIRYILEMSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFR 664
             ++ ++W +P  DG SP++ Y +E  E N   W  +  ++ P        GL    +Y+FR
Sbjct: 21274 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVP-GNIFKSSGLTDGIAYEFR 21332

Query: 665   LCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI-L 723
             + A N  GK + SK +E +   +  P  PP   +    T  ++ ++W  P   +  G  +
Sbjct: 21333 VIAENMAGKSKPSKPSEPMLALD--PIDPPGKPVPLNITRHTVTLKWAKP--EYTGGFKI 21388

Query: 724   KGYIIRYCLAGLPVGYQFK-NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKV 782
               YI+      LP G   K N ++   N   +  L     YE  V A N+AG        
Sbjct: 21389 TSYIVE--KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAG-------- 21438

Query: 783   TEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTM 842
                        PP    +E +++ T R    AP  +          L A E  + E    
Sbjct: 21439 --------AISPP----SEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVS 21486

Query: 843   VTARPNFQDSIHVGFVSGLK----KFTEYFTSVL----------CFTTPGDGPRSTPQLV 888
                 P  + S     + G      K  ++ T+++           +T     P    + +
Sbjct: 21487 GRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHI 21546

Query: 889   RTHE--DVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTH 944
                +  D PG P G L+ +E+      +SW  P +  G  +  Y +   E +R       
Sbjct: 21547 FNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVA 21606

Query: 945   YLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPTNLGISN 1003
                 VT + +VT L     Y   V A+   G G+ + +  + +  P   P PP N  ++ 
Sbjct: 21607 SEVQVT-KLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTT 21665

Query: 1004  IGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN 1062
             I   S+ + +  P  DG + I  ++VE +      G+ W+  ++     D R  +V  L 
Sbjct: 21666 ITKDSMVVCWGHPDSDGGSEIINYIVERRDKA---GQRWIKCNK-KTLTDLR-YKVSGLT 21720

Query: 1063  PFTCYSFRMRQVNIVGTSPPSQPS---RKIQTLQAPPDMAPANVSLRTASETSLWLRW-M 1118
                 Y FR+   N  G S PS  S   +   T+  P    P N  +   S +S+ + W  
Sbjct: 21721 EGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPG--PPGNPRVLDTSRSSISIAWNK 21778

Query: 1119  PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 1178
             P+    Y+G  E  GY ++ +  +     +           YTI  L E  EY++++ A 
Sbjct: 21779 PI----YDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAM 21834

Query: 1179  NAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVR---------------WSEV 1223
             N+ G G     +V  T ++     P  +   A     + +R                 EV
Sbjct: 21835 NSEGLG--EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 21892

Query: 1224  PEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG 1283
               A  +G     + + K     T     L+ GN +R       GKY+L          + 
Sbjct: 21893 KWARDHG-----ESLDKASIESTSSYTLLIVGNVNRFDS----GKYIL---------TVE 21934

Query: 1284  DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTT 1343
             + S S    +   + D PGPP  +   EV  TSV L W PP    G  +   I  +  +T
Sbjct: 21935 NSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKREST 21994

Query: 1344  TANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPP 1403
                 +TV         +    L+    Y FR+ A+   G G  AE    + +  +RP PP
Sbjct: 21995 RKAYSTVATNCHKT-SWKVDQLQEGCSYYFRVLAENEYGIGLPAET-AESVKASERPLPP 22052

Query: 1404  SRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFI 1462
              +  +   DV   SV LSWE P  DG S +  Y ++ +   S +WA      +   +   
Sbjct: 22053 GK--ITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWA---TCATVKVTEAT 22107

Query: 1463  VDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRW 1522
             +  L     Y FRV A N+ G S+                  P  LSV P     ++I  
Sbjct: 22108 ITGLIQGEEYSFRVSAQNEKGISD------------------PRQLSV-PVIAKDLVI-- 22146

Query: 1523  QPPAEDKINGILLGFRIRYRELLYEGLRGFTLR------GINNPGATW------AELTSM 1570
              PPA          F++ +    +  L G  L+      G   P  TW       + T+ 
Sbjct: 22147 -PPA----------FKLLFN--TFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTR 22193

Query: 1571  YSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNV 1630
              +  +    SL   +         Y ++++  N+ GE   +    V      PT     V
Sbjct: 22194 VNAESTENNSLLTIKDACREDVGHYVVKLT--NSAGEAIETLNVIVLDKPGPPTGP---V 22248

Query: 1631  VVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNL 1690
              +   TA  + ++W PP  D     I  Y +   +      T ++ +  +A  ++K   L
Sbjct: 22249 KMDEVTADSITLSWGPPKYDG-GSSINNYIVE--KRDTSTTTWQIVSATVARTTIKACRL 22305

Query: 1691  TGYTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQ 1748
                  Y   +AA N  G      S PT  Q     P  P +   +  +  S+ V W    
Sbjct: 22306 KTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWN--- 22362

Query: 1749  FPNGILEGYRLVYEPCSPVDGVSKIVTVDV---KGNSPLWLKVK------------DLAE 1793
                          EP S  DG S+++   +   + NS LW+K+              L E
Sbjct: 22363 -------------EPIS--DGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEE 22407

Query: 1794  GVTYRFRIRAKTFT----YGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD- 1848
             GV Y FR+ A+            E  V   P +  PG P   I+ R  +++ + W     
Sbjct: 22408 GVEYEFRVSAENIVGIGKPSKVSECYVARDPCD-PPGRPEAIIVTR--NSVTLQWKKPTY 22464

Query: 1849  PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG- 1907
              G   IT Y++E +   EG W   +K     +    F +  L     Y+FRVIA N  G 
Sbjct: 22465 DGGSKITGYIVEKKELPEGRW---MKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGV 22521

Query: 1908  FGTPSSPSQSVPAQ 1921
             F  PS  + ++ A+
Sbjct: 22522 FSEPSESTGAITAR 22535



 Score =  210 bits (535), Expect = 1e-53
 Identities = 345/1488 (23%), Positives = 556/1488 (37%), Gaps = 155/1488 (10%)

Query: 506   SVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIR-LDRNGSLHISQTWSGDI 564
             +V  GT+  +   VT  P   I   W K    L  +    I  + +  ++ I  +   D 
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKIT--WTKADMILKQDKRITIENVPKKSTVTIVDSKRSDT 13758

Query: 565   GTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLI 623
             GTY    ++  G  +    + V   P  P      ++ V   +  LTW  P D G S + 
Sbjct: 13759 GTYIIEAVNVCGRATAVVEVNVLDKPGPPA--AFDITDVTNESCLLTWNPPRDDGGSKIT 13816

Query: 624   RYILEMSENNAP-WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTER 682
              Y++E    ++  W  L ++V  K T+     L+P + Y FR+ A N  G G+  + +  
Sbjct: 13817 NYVVERRATDSEVWHKLSSTV--KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPI 13874

Query: 683   VSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFK 742
              +  +  P  PP  +  S  T  ++ + W  P +   + I  GY +           +  
Sbjct: 13875 TAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPIT-GYWVERLDPDTDKWVRCN 13933

Query: 743   NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGV--PTVPPGNVHA 800
              +   D     ++ L     Y   V A N AG G  S       ++    P  PPG    
Sbjct: 13934 KMPVKDTT-YRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTV 13992

Query: 801   EATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSG 860
             +    T++R  W  P       I + Y +   +   +E V +    P  Q       + G
Sbjct: 13993 KDVGKTSVRLNWTKPEHDGGAKI-ESYVIEMLKTGTDEWVRVAEGVPTTQH-----LLPG 14046

Query: 861   LKKFTEYFTSVLCFTTPGDGPRSTPQ---LVRTHEDVPGPVGHLSFSEILDTSLKVSWQE 917
             L +  EY   V      G+   S P    L R     P P   L    I   +  + W  
Sbjct: 14047 LMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTV 14106

Query: 918   PGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQ 976
             P +  G  +T Y +   +  R   +        T +  VT LT  + Y   VAA  + GQ
Sbjct: 14107 PEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDT-KCTVTPLTEGSLYVFRVAAENAIGQ 14165

Query: 977   GQVSA--STISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVG 1033
                +    ++ +      PGPP  L + ++  R V L++ P   DG   I R+++E +  
Sbjct: 14166 SDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKER 14225

Query: 1034  VVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ 1093
             +   G  W+   + +  PD  +  V D+   T   F++R  N  G   PS+P+ +I +++
Sbjct: 14226 L---GTRWVKAGKTAG-PDC-NFRVTDVIEGTEVQFQVRAENEAGVGHPSEPT-EILSIE 14279

Query: 1094  AP--PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKI--------KYSRSDG 1143
              P  P   P ++ +  A    + + W P    E NG    +GY +        K+ R + 
Sbjct: 14280 DPTSPPSPPLDLHVTDAGRKHIAIAWKP---PEKNGGSPIIGYHVEMCPVGTEKWMRVNS 14336

Query: 1144  HG-KTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG---SGPWSQTVVGRTRESVP 1199
                K L   V++ V  D          EY ++V+A NAIG       S+ VV +  +  P
Sbjct: 14337 RPIKDLKFKVEEGVVPD---------KEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKP 14387

Query: 1200  SSG--PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNS 1257
             +      ++  +     S+ V +  VP       V  +K   + K SD      L   N 
Sbjct: 14388 TIDLETHDIIVIEGEKLSIPVPFRAVPVPT----VSWHKDGKEVKASDR-----LTMKND 14438

Query: 1258  SRSAQLTGLGKYVLYEVQVLAFT---RIGDGSPSHPPILERTLDDVPGPPMGILFPEVRT 1314
               SA L  + K V  +  +   T   ++G  + S    +   +  +PGP   I   ++  
Sbjct: 14439 HISAHLE-VPKSVRADAGIYTITLENKLGSATAS----INVKVIGLPGPCKDIKASDITK 14493

Query: 1315  TSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFR 1374
             +S +L W+PP    G  + + +  R          V +   +   +T   L P   Y FR
Sbjct: 14494 SSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPV-MSGENKLSWTVKDLIPNGEYFFR 14552

Query: 1375  ITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPM-VQQEDVRARSVLLSWEPGS-DGLSPV 1432
             + A  + G GE  E L      +D  QPP  P+ V+  +  A ++ ++W+P   DG S +
Sbjct: 14553 VKAVNKVGGGEYIE-LKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKI 14611

Query: 1433  RYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESE 1492
               Y I+       RW   +  +     ++    L+    Y+FRV+A N  G SE S  + 
Sbjct: 14612 MGYIIEKIAKGEERWKRCNEHLVP-ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATP 14670

Query: 1493  SLTTLQAAPDEAPTIL-------------------SVTPHTTTSVLIRWQP------PAE 1527
                T    P +AP ++                   S +P+ T    I W        P E
Sbjct: 14671 P--TKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPT----ITWIKDENVIVPEE 14724

Query: 1528  DKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELD 1587
              K     L   +R R+   +    F L            LT   S+ N  +        D
Sbjct: 14725 IKKRAAPL---VRRRKGEVQEEEPFVL-----------PLTQRLSIDNSKKGESQLRVRD 14770

Query: 1588  NLNK-HRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEP 1646
             +L   H  Y I++   + + + P +      V        P N V      T +   WEP
Sbjct: 14771 SLRPDHGLYMIKVENDHGIAKAPCT------VSVLDTPGPPINFVFEDIRKTSVLCKWEP 14824

Query: 1647  PPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAA 1706
             P LD    +I  Y +   +  + +    V T  L      +  L     Y+  V A N  
Sbjct: 14825 P-LDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRF 14883

Query: 1707  GDGPR--STPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPC 1764
             G GP   S P   +     P AP      ++T+ S+ V W  P+     + GY L     
Sbjct: 14884 GPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREV 14943

Query: 1765  SPV--DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT----YGPEIEANVTT 1818
             +      V+K +   +K N      V  L EG+TY FR+ A+       + P  +     
Sbjct: 14944 NSTHWSRVNKSLLNALKAN------VDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAH 14997

Query: 1819  GPGEGAPGPPGVPIIVRYSSAIAIHWSS-GDPGKGPITRYVIEARPSDEGLWDILIKDIP 1877
              P    PGPP   +    S+ I + W      G G I  Y ++ +      W    + + 
Sbjct: 14998 DP-ISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMI 15056

Query: 1878  KEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
             K V  YT     ++ G  Y  RV AVN  G G P        A+   P
Sbjct: 15057 K-VRQYTVKE--IREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEP 15101



 Score =  207 bits (527), Expect = 9e-53
 Identities = 337/1448 (23%), Positives = 550/1448 (37%), Gaps = 155/1448 (10%)

Query: 523   PRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGGNDSRS 581
             P+ T+   W KDG TL   +   +   +   SL I +    D+GTY   V ++ G+ +  
Sbjct: 25422 PQATVN--WRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 25479

Query: 582   AHLRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP-WTVL 639
               + V   P  P  P+  +  V   +I ++W  P +DG   +  YI+E  E  +  W ++
Sbjct: 25480 ITIIVLDRP-GPPGPIR-IDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIV 25537

Query: 640   LASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIA 699
               +V    TS+ +  L     YQFR+CA N  GK  +S+ +  V+     P  PP     
Sbjct: 25538 SQAV--ARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKV 25595

Query: 700   SGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLII 759
                T  ++++ WQ P     + ++ GY + Y      +  +   I  AD   + +  L  
Sbjct: 25596 VHATKSTMLVTWQVPVNDGGSRVI-GYHLEYKERSSILWSKANKILIADTQ-MKVSGLDE 25653

Query: 760   WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQF 819
                YE  V A N AG+G   SK  E      P  PPG          ++   W+ P    
Sbjct: 25654 GLMYEYRVYAENIAGIGK-CSKSCEPVPARDPCDPPGQPEVTNITRKSVSLKWSKPH--- 25709

Query: 820   INGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEY----FTSVLCF 874
                 + G K+  +  E+ E       + N+ +     F V+ L +   Y    F      
Sbjct: 25710 ---YDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAAD 25766

Query: 875   TTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTS----LKVSWQEPGEKNGILTGYRI 930
             +       + P +V+   + P  +  + F +++       LK++    G    +++  + 
Sbjct: 25767 SVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKD 25826

Query: 931   SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPP 990
               E   R  T +     +  L  +         Y + +  +       V+   +      
Sbjct: 25827 GIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDK---- 25882

Query: 991   ELPGPPTN-LGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLS 1048
               PGPP   L I+ +     +L + RP  DG   I  ++VE +         W +     
Sbjct: 25883 --PGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRET---SHLAWTICE--- 25934

Query: 1049  NEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPP--SQPSRKIQTLQAPPDMAPANVSLR 1106
              E    S +V  L     Y FR+  VN  G   P  S   + +     P    P ++ + 
Sbjct: 25935 GELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSP--PTSLEIT 25992

Query: 1107  TASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHV-VQDRVERDYTIED- 1164
             + ++ S+ L W      E +G  E  GY I+    +    +L  V V  +   D  ++  
Sbjct: 25993 SVTKESMTLCWS---RPESDGGSEISGYIIERREKN----SLRWVRVNKKPVYDLRVKST 26045

Query: 1165  -LEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESV----PSSGPTNVSALATTSSSMLV 1218
              L E  EY  +V A NA G S P   + + R  + V    P S P  V +  TT   + +
Sbjct: 26046 GLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT---ITI 26102

Query: 1219  RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLT--GLGKYVLYEVQV 1276
              W + P  D    + GY V YK+ D DT    W     S R  + T  GL     Y  +V
Sbjct: 26103 AWVK-PLFDGGAPITGYTVEYKKSD-DTD---WKTSIQSLRGTEYTISGLTTGAEYVFRV 26157

Query: 1277  LAFTRIGDGSPSH---PPILERTLDDVPGPPMGILFPEVRTTSV---RLIWQPPAAPNGI 1330
              +  ++G   PS    P I +   ++    P+  +  E+R T +      +       G 
Sbjct: 26158 KSVNKVGASDPSDSSDPQIAKEREEE----PLFDIDSEMRKTLIVKAGASFTMTVPFRGR 26213

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL 1390
              +   +  + +T     A V+    S    T           + +T Q       +A +L
Sbjct: 26214 PVPNVLWSKPDTDLRTRAYVDT-TDSRTSLTIENANRNDSGKYTLTIQNVL----SAASL 26268

Query: 1391  VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWAL 1449
              +  +  D P PP+   VQ  DV   S +LSW+ P +DG +PV+ Y I+ RE     W  
Sbjct: 26269 TLVVKVLDTPGPPTNITVQ--DVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWV- 26325

Query: 1450  HSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILS 1509
              S + + N  S+ V  L+    Y FRV   N+ G    +E  E +   +      P  L 
Sbjct: 26326 -SVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKP--SPPEKLG 26382

Query: 1510  VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 1569
             VT  +  SV + W  P  D       G RI +          + +  +      W +   
Sbjct: 26383 VTSISKDSVSLTWLKPEHDG------GSRIVH----------YVVEALEKGQKNWVKCAV 26426

Query: 1570  MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV------P 1623
               S         T + +  L ++  Y  R+   N  G    S P+E+ +   +      P
Sbjct: 26427 AKS---------THHVVSGLRENSEYFFRVFAENQAG---LSDPRELLLPVLIKEQLEPP 26474

Query: 1624  TAAPRN-----VVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTL 1678
                 +N     V V   +  ++D+     PL        G  +          T R  T 
Sbjct: 26475 EIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPL--------KATMRFNTE 26526

Query: 1679  FLAEN-SVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTT 1737
               AEN ++ LK      A    + A N++G            +   P+ P  V  S++T 
Sbjct: 26527 ITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGP--VVISDITE 26584

Query: 1738  TSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVT 1796
              SV + WE P++  G  +  Y L+    S         TV     +   +KV  L  G  
Sbjct: 26585 ESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATV-----ARTMMKVMKLTTGEE 26639

Query: 1797  YRFRIRAKT-FTYGPEIE-ANVTTGPGEGAPGPPGVPIIVRYS-SAIAIHWSSG-DPGKG 1852
             Y+FRI+A+  F     I+ A VT       PGPP  P +   +  +I + W      G  
Sbjct: 26640 YQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGS 26699

Query: 1853  PITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPS 1912
              +  Y +E +  +  LW    K +   + +  F +  +  G+ Y+FRV A N  G G PS
Sbjct: 26700 AVVGYHLEMKDRNSILWQKANKLV---IRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS 26756

Query: 1913  SPSQSVPA 1920
              PS+ V A
Sbjct: 26757 HPSEPVLA 26764



 Score =  207 bits (526), Expect = 1e-52
 Identities = 333/1443 (23%), Positives = 538/1443 (37%), Gaps = 164/1443 (11%)

Query: 531   WEKDGATLGTESHPRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
             W  DG+ + T+ H  +  D   S L I      D G Y   V +A G+ + + HL V  +
Sbjct: 17544 WTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDV 17603

Query: 590   PHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLASVDPKAT 648
             P  P  P+  L       + ++W  P D G SP+I YI+E  +       +++S   K T
Sbjct: 17604 PGPPTGPINILDVTPEH-MTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSK-T 17661

Query: 649   SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIM 708
              + +  L     Y FR+ A N +G G     T  V+  +  P +PP   + +  T  +  
Sbjct: 17662 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 17721

Query: 709   IQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768
             + W  P     + I   Y+ R  + G  V      I D       +  L     YE  V 
Sbjct: 17722 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADL---KFRVTGLYEGNTYEFRVF 17778

Query: 769   AYNSAGLG--VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQG 826
             A N AGL     SS   +      P  PP N   +  +  T    W  P        + G
Sbjct: 17779 AENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLS------DGG 17832

Query: 827   YKLIAWEPEQEEEVTMVTARPNFQDSIH--VGFVSGLKKFTEYFTSVLCFTTPGDG-PRS 883
               ++ +  E ++  T    R N  + I      V GL +  EY   +      G+G PR 
Sbjct: 17833 SPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRE 17892

Query: 884   TPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYR------ISWEEYNR 937
               + V     +   + H    E+  T   V     G+   IL   +      I+W +  +
Sbjct: 17893 LAESV-----IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGK 17947

Query: 938   TNTR-----VTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992
                R     +   LP V L+ +         Y I     +   QG    + +      + 
Sbjct: 17948 VLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVL------DR 18001

Query: 993   PGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
             PGP  NL ++N+   + T+ +  P  +G + I+ ++VE +       + W ++   +++ 
Sbjct: 18002 PGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR---KPNQKGWSIV---ASDV 18055

Query: 1052  DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQ---PSRKIQTLQAPPDMAPANVSLRTA 1108
               R ++  +L     Y FR+   N VG  P  +   P   I  +  P +  P N+ +   
Sbjct: 18056 TKRLIKA-NLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGE--PENLHIADK 18112

Query: 1109  SETSLWLRWMPLPEMEYNGNPESVGYKI--KYSRSDGHGKTLSHVVQDRVERDYTIEDLE 1166
              +T ++L+W      +Y+G   ++ Y +  +   SD   +     ++   E  Y ++   
Sbjct: 18113 GKTFVYLKWR---RPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIK---ETHYMVDRCV 18166

Query: 1167  EWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPS-------SGPTNVSALATTSSSMLVR 1219
             E   Y  +VQ  N  G   W +T     +E +         SG   V A  T      VR
Sbjct: 18167 ENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVR 18226

Query: 1220  WSEVPEA----DRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQ 1275
                 PE     D++   L      K        +F L +   S        GKYV     
Sbjct: 18227 GKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDG------GKYV----- 18275

Query: 1276  VLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQ 1335
             V A    G    S        + D PGP   +   +V +    + W PP    G  +   
Sbjct: 18276 VTATNTAG----SFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNY 18331

Query: 1336  ITHRLNTTTA--NTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VV 1392
             I  +  T     +T +  VL P     T T L   + Y+FR+ A+ + G G   E+  V+
Sbjct: 18332 ILEKCETKRMVWSTYSATVLTPGT---TVTRLIEGNEYIFRVRAENKIGTGPPTESKPVI 18388

Query: 1393  TTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSGRWA-LH 1450
                K D+P  P  P V +  V    + + W P   DG   +  Y ++ +E  S RW  ++
Sbjct: 18389 AKTKYDKPGRPDPPEVTK--VSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVN 18446

Query: 1451  SASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQ-AAPDEAPTILS 1509
              +++        V  L P   Y+FRVKA N+IG  E S  S  +       P   PT   
Sbjct: 18447 KSAIPERRMK--VQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFR 18504

Query: 1510  VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 1569
             V   T  S+ + W  P  D     ++G+ +  R  + +           +P   W    +
Sbjct: 18505 VVDTTKHSITLGWGKPVYDG-GAPIIGYVVEMRPKIADA----------SPDEGWKRCNA 18553

Query: 1570  MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG------PSSPPQEVFVGEAVP 1623
                +         ++ + +L++++ YE R+   N VG G       +  P+E+     + 
Sbjct: 18554 AAQLVR------KEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEID 18607

Query: 1624  TAAP--RNVVVHGATATQL--DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTL- 1678
               A   + V+V      +L   V   P P       +   K+      R    + V T+ 
Sbjct: 18608 LDASMRKLVIVRAGCPIRLFAIVRGRPAP------KVTWRKVGIDNVVRKGQVDLVDTMA 18661

Query: 1679  FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
             FL   +    +   Y+  +V+ A   A     R   T        P   S +K S++T T
Sbjct: 18662 FLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDT--------PGPVSDLKVSDVTKT 18713

Query: 1739  SVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYR 1798
             S +VSW  P+   G    + +V E           VT +VK  S     V +L  G  Y 
Sbjct: 18714 SCHVSWAPPENDGGSQVTHYIV-EKREADRKTWSTVTPEVKKTS---FHVTNLVPGNEYY 18769

Query: 1799  FRIRAKTFTYGPEIEANV-----TTGPGEGAPGPPGVPIIVRYSSAIAIHW-----SSGD 1848
             FR+ A    YGP +  +V      + P      P  + +     ++  + W       G 
Sbjct: 18770 FRVTAVN-EYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGA 18828

Query: 1849  PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGF 1908
                G IT Y  E +P+D      ++KD+   V+        LK G  Y FRV A N  G 
Sbjct: 18829 KIDGYITSYREEEQPADRWTEYSVVKDLSLVVTG-------LKEGKKYKFRVAARNAVGV 18881

Query: 1909  GTP 1911
               P
Sbjct: 18882 SLP 18884



 Score =  204 bits (520), Expect = 6e-52
 Identities = 375/1638 (22%), Positives = 639/1638 (39%), Gaps = 191/1638 (11%)

Query: 362   DGGLQISGLVPDDTGMFQCFARNAAG---EVQTSTYLAVTS----IAPNITRGP--LDST 412
             D   +++GLV D    F+  ARNAAG   E   ST  A+T+      P I+  P   D+ 
Sbjct: 22495 DTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTG-AITARDEVDPPRISMDPKYKDTI 22553

Query: 413   VID-GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
             V+  G S  +  +  G P P I W KG++ L S + +L   +   + SL +      D+G
Sbjct: 22554 VVHAGESFKVDADIYGKPIPTIQWIKGDQEL-SNTARLEIKSTDFATSLSVKDAVRVDSG 22612

Query: 472   TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQA---------------SMV 516
              Y   A N  G    + ++ V  R     PP+   VI G  A               S +
Sbjct: 22613 NYILKAKNVAGERSVTVNVKVLDR---PGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDI 22669

Query: 517   CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG- 575
                  + R T R +W    A + T            S  +++   G+   YT R+++   
Sbjct: 22670 INYIVERRETSRLVWTVVDANVQTL-----------SCKVTKLLEGN--EYTFRIMAVNK 22716

Query: 576   ---GNDSRSAHLRVRQ---LPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILE 628
                G    S  +  +    +P AP+ P  T  TV + ++ + W +P  DG S ++ Y+LE
Sbjct: 22717 YGVGEPLESEPVVAKNPFVVPDAPKAPEVT--TVTKDSMIVVWERPASDGGSEILGYVLE 22774

Query: 629   MSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT--ERVSL 685
               +     WT     +  +   + V GL+    Y+FR+ A N  G  + S  +  ++   
Sbjct: 22775 KRDKEGIRWTRCHKRLIGE-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACD 22833

Query: 686   PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNI 744
             P   P  PP N      T  S+ + W  P   +  G  ++GYI+  C   +         
Sbjct: 22834 PIYKP-GPPNNPKVIDITRSSVFLSWSKP--IYDGGCEIQGYIVEKCDVSVGEWTMCTPP 22890

Query: 745   TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATN 804
             T  +  N+ +E L+    Y   + A N AG+G ++       ++     P  ++  E   
Sbjct: 22891 TGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRK 22950

Query: 805   STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEE--EVTMVTARPNFQDSIHVGFVSGLK 862
                IR         F+    +    + W     E  +  ++    +F   +       L 
Sbjct: 22951 IINIRA--GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLV-------LD 23001

Query: 863   KFTEYFTSVLCFTTP-GDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEK 921
                 Y +     T     G +S    VR   D P P  +L  +EI   S+ ++W+ P   
Sbjct: 23002 NVNRYDSGKYTLTLENSSGTKSAFVTVRV-LDTPSPPVNLKVTEITKDSVSITWEPPLLD 23060

Query: 922   NGI-LTGYRISWEEYNRTN--TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ 978
              G  +  Y +   E  R +    VT+   N    +++  L    +Y   V A    G G 
Sbjct: 23061 GGSKIKNYIVEKREATRKSYAAVVTNCHKN---SWKIDQLQEGCSYYFRVTAENEYGIG- 23116

Query: 979   VSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGE 1037
             + A T       E+P PP  + + ++   SV+L + +P +DG + I +++VE Q      
Sbjct: 23117 LPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQ---AKH 23173

Query: 1038  GEEWLLIHQLSNEPDARSME--VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKI--QTLQ 1093
              E+W      S     +S++  + +L     Y FR+  VN  G S P   +  I  + L 
Sbjct: 23174 SEKW------SECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLV 23227

Query: 1094  APPDMAPA--NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHV 1151
               PD+ PA  + S++   +  +        E+  +G P+     I +++     K  + +
Sbjct: 23228 IEPDVKPAFSSYSVQVGQDLKI--------EVPISGRPKPT---ITWTKDGLPLKQTTRI 23276

Query: 1152  -VQDRVE-RDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSAL 1209
              V D ++    +I++  +    +  +   N +G    S  +V   +   P  GP     +
Sbjct: 23277 NVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPD-PPKGPVKFDDV 23335

Query: 1210  ATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW-LVEGNSSRSA-QLTGLG 1267
               ++ S+ + W+  P     G  +   ++ K    DT    W +V    +R+  ++T L 
Sbjct: 23336 --SAESITLSWN--PPLYTGGCQITNYIVQKR---DTTTTVWDVVSATVARTTLKVTKLK 23388

Query: 1268  KYVLYEVQVLAFTRIGDG-SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAA 1326
                 Y+ ++ A  R G   +    PI+ +     PGPP       +   S+ + W  P  
Sbjct: 23389 TGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVN 23448

Query: 1327  PNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGE 1385
               G  ++ Y +  +   +   T   + +     Q+ A  L+    Y FR+ A+   G G+
Sbjct: 23449 NGGSPVIGYHLERKERNSILWTKVNKTIIHDT-QFKAQNLEEGIEYEFRVYAENIVGVGK 23507

Query: 1386  AAE--ALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTREL 1442
             A++     V  +  D P  P   MV++ +     + L W +P  DG S +  Y ++ R+L
Sbjct: 23508 ASKNSECYVARDPCDPPGTPEPIMVKRNE-----ITLQWTKPVYDGGSMITGYIVEKRDL 23562

Query: 1443  PSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 1502
             P GRW + ++  +   + F V  L     Y+FRV A N  G    S+ S+S   + A  +
Sbjct: 23563 PDGRW-MKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG--AISKPSDSTGPITAKDE 23619

Query: 1503  EAPTILSVTPHTTTSVLIRWQPP--AEDKINGILLGFRIRYRELLYEGLRG-FTLRGINN 1559
                  +S+ P    ++++        E  ++G  L           E LRG   +     
Sbjct: 23620 VELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP--------TIEWLRGDKEIEESAR 23671

Query: 1560  PGATWAELTSMYSMRNLSRPSLTQYEL--DNLNKHRRYEIRMSVYNAVG--EGPSSPPQE 1615
                   +  ++  +++  R    QY L   N+   + + + + V +  G  EGP      
Sbjct: 23672 CEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGP------ 23725

Query: 1616  VFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERV 1675
                           V V G T+ +  +TW  PPL     DI  Y +   E  R  L   V
Sbjct: 23726 --------------VQVTGVTSEKCSLTWS-PPLQDGGSDISHYVVEKRETSR--LAWTV 23768

Query: 1676  KTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFS 1733
                 +  NS+K+  L     Y+  + A N  G G    S P   +     P  P S++ +
Sbjct: 23769 VASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVT 23828

Query: 1734  ELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLA 1792
              +   S+ V W  P    G  + GY +     S +    + +  + +  + L L+V  L 
Sbjct: 23829 NIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGI----RWIKCNKRRITDLRLRVTGLT 23884

Query: 1793  EGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGA--PGPP-GVPIIVRYSSAIAIHWSSGD 1848
             E   Y FR+ A+     G    A V     +    PGPP    I+    ++I + W  G 
Sbjct: 23885 EDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAW--GK 23942

Query: 1849  P---GKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVND 1905
             P   G   I  YV+E   +DE  W I+       V+ +  S   L     Y  RV A+N 
Sbjct: 23943 PIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISK--LTEHQEYKIRVCALNK 24000

Query: 1906  YGFGTPSS-PSQSVPAQK 1922
              G G  +S P    P  K
Sbjct: 24001 VGLGEATSVPGTVKPEDK 24018



 Score =  202 bits (515), Expect = 2e-51
 Identities = 431/1978 (21%), Positives = 725/1978 (36%), Gaps = 286/1978 (14%)

Query: 73    EYRYMITSLDRTHAGFYRCIVRNRMGAL----------LQRQTEVQ--VAYMGSFEEGEK 120
             E +Y +T L       +R I RN +G +          + R   V   V +   + +G  
Sbjct: 27910 ECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDG-- 27967

Query: 121   HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAIT--LENTLVILSTVAPDA 178
                +  GE+  I+A  +   P P+VTWF+DG +I     + IT  L +T + +     D 
Sbjct: 27968 -LIIKSGESLRIKA-LVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDH 28025

Query: 179   GRYYVQAVNDKNGDNKTSQPITL--TVENVGGPA-------------------DPIAPTI 217
                Y     + +G  K    + +  T   V GP                    D  AP  
Sbjct: 28026 RGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPIT 28085

Query: 218   --IIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPT 275
               II  + TS +A    +  +C A +   IKL      +G      +S  N+   +  P 
Sbjct: 28086 HYIIEKRETSRLAWAL-IEDKCEAQSYTAIKLI-----NGNEYQFRVSAVNK-FGVGRPL 28138

Query: 276   GSDAGYYECEAVLRSSS---VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQA 332
              SD    + +  +  +     PS + G  +++         PE    +E+++ +    + 
Sbjct: 28139 DSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWA-----RPESDGGSEIQQYILERREK 28193

Query: 333   KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTS 392
             K     S  W K  +   + + TRF+        ++GL   +   F   A NAAG    S
Sbjct: 28194 K-----STRWVKVISKRPISE-TRFK--------VTGLTEGNEYEFHVMAENAAGVGPAS 28239

Query: 393   ------------------TYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT 434
                               T + VT  +           V DG   ++             
Sbjct: 28240 GISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD 28299

Query: 435   WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGV-DEASADLVVW 493
             W K   + A   V+  R+T        ++     +   +   A N  G  D       + 
Sbjct: 28300 WHK---VNAEACVKT-RYT--------VTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIK 28347

Query: 494   ARTRITKPPQD------QSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIR 547
             A  R+T P  D      Q+ +    AS+   + +  R T   +W K  + L   +     
Sbjct: 28348 AVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTT 28407

Query: 548   LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRA 607
              D   +L +      D G YT  V +  G+ S +  ++V   P  P  P+ T   V R +
Sbjct: 28408 -DSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTP-GPPGPI-TFKDVTRGS 28464

Query: 608   INLTWTKPF-DGNSPLIRYILEMSE-NNAPWTVLLASVDPKATS--VTVKGLVPARSYQF 663
               L W  P  DG + +  Y++E  E +   W V    +  K T     V  L     Y F
Sbjct: 28465 ATLMWDAPLLDGGARIHHYVVEKREASRRSWQV----ISEKCTRQIFKVNDLAEGVPYYF 28520

Query: 664   RLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI- 722
             R+ AVN+ G G+  +  E +   E+P  APP+ +     +  S ++ W  P   H  G  
Sbjct: 28521 RVSAVNEYGVGEPYEMPEPIVATEQP--APPRRLDVVDTSKSSAVLAWLKP--DHDGGSR 28576

Query: 723   LKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLG----VY 778
             + GY++     G     +  +          +E L+  T YE  V A N AG       +
Sbjct: 28577 ITGYLLEMRQKGSDFWVEAGHTKQL---TFTVERLVEKTEYEFRVKAKNDAGYSEPREAF 28633

Query: 779   SSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQG-------YKLIA 831
             SS + +      P + P    A+ T  T    T  A SP  I+    G       +KL  
Sbjct: 28634 SSVIIK-----EPQIEPT---ADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEE 28685

Query: 832   WEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTH 891
                ++ + V++ T +     ++         +   YF ++    T G    S   +V   
Sbjct: 28686 MRLKETDRVSITTTKDRTTLTVKDSMRGDSGR---YFLTLE--NTAGVKTFSVTVVVIGR 28740

Query: 892   EDVPGPV-GHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNV 949
                PGPV G +  S +   S  +SW EP +  G  +T Y +   E   T  ++ +     
Sbjct: 28741 ---PGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKR 28797

Query: 950   TLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPTNLGISNIGPRS 1008
             T + +VT LT    Y+  V++    G  + + ++ I +  P   P  PT   + ++   +
Sbjct: 28798 T-QIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANA 28856

Query: 1009  VTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067
             +++++  P +DG + I  + VE +     E    L + +        + +V  L     Y
Sbjct: 28857 MSIRWEEPYHDGGSKIIGYWVEKK-----ERNTILWVKENKVPCLECNYKVTGLVEGLEY 28911

Query: 1068  SFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNG 1127
              FR   +N  G S  S+ SR I   Q P D AP    +   + +++ L W       Y+G
Sbjct: 28912 QFRTYALNAAGVSKASEASRPIMA-QNPVD-APGRPEVTDVTRSTVSLIWSA---PAYDG 28966

Query: 1128  NPESVGYKI--KYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGP 1185
               + VGY I  K     G G+ L        +  +T+  L E   Y  +V A NA G   
Sbjct: 28967 GSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAG--- 29023

Query: 1186  WSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSD 1245
                 V+ +  ES       +  A         +    V     + LVL   V  K     
Sbjct: 29024 ----VISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKP---- 29075

Query: 1246  TQPRFWLVEGNSSR------SAQLTGL--------------GKYVLYEVQVLAFTRIGDG 1285
              +P+    +G+         S Q TG               GKY L          +   
Sbjct: 29076 -EPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVS-- 29132

Query: 1286  SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTA 1345
                   ++ + LD  PGP   +    V      L W  P    G  + + I  R  T+  
Sbjct: 29133 ------VMVKVLDS-PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRL 29185

Query: 1346  NTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VVTTEKRDRPQPPS 1404
             N   VE   P+   Y  T L   + Y+FR+ A  + G G   E+  +V       P PP 
Sbjct: 29186 NWVIVEGECPTL-SYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG 29244

Query: 1405  RPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIV 1463
              P  ++       +++ W +P SDG + +  Y +  RE  S RW   +       +   V
Sbjct: 29245 IP--EEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKV 29302

Query: 1464  DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA----PDEAPTILSVTPHTTTSVL 1519
               L     Y+FRV A N  G+SE SE S  ++  + +    P  AP ++  T H   S+ 
Sbjct: 29303 TSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKH---SIS 29359

Query: 1520  IRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRP 1579
             + W  P  D    I+                G+ L         W  + +  ++RN    
Sbjct: 29360 LAWTKPMYDGGTDIV----------------GYVLEMQEKDTDQWYRVHTNATIRN---- 29399

Query: 1580  SLTQYELDNLNKHRRYEIRMSVYNAVGEGPSS-------PPQEVFVGE-AVPTAAPRNVV 1631
               T++ + +L   ++Y  R++  N  G    S       P + + + +  +     + V 
Sbjct: 29400 --TEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVT 29457

Query: 1632  VHGATATQL--DVTWEPPPL---DSQNGDIQGYKIY-FWEAQRGNLTERVKTLFLAENSV 1685
             +    + +L   V+  PPP+     Q  D+    I    E+    + ++V      + ++
Sbjct: 29458 IRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTI 29517

Query: 1686  KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE 1745
             + +N +G  +  V V  ++  G  P                  SVK  E++  SV ++WE
Sbjct: 29518 EAENQSGKKSATVLVKVYDTPGPCP------------------SVKVKEVSRDSVTITWE 29559

Query: 1746  APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT 1805
              P    G      +V +  +    +    TV  K +  L+ ++  L EG  Y FR+  + 
Sbjct: 29560 IPTIDGGAPVNNYIVEKREA---AMRAFKTVTTKCSKTLY-RISGLVEGTMYYFRVLPEN 29615

Query: 1806  -FTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSG-DPGKGPITRYVIEARP 1863
              +  G   E +      E    P  + ++    S + + W      G   +T YV+EA  
Sbjct: 29616 IYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACK 29675

Query: 1864  SDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQ 1921
             +    W   +K +  + +    ++  L  G  Y FR+ A N+ G   P     +V  Q
Sbjct: 29676 AGTERW---MKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQ 29730



 Score =  201 bits (512), Expect = 5e-51
 Identities = 369/1646 (22%), Positives = 603/1646 (36%), Gaps = 237/1646 (14%)

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP---LDSTVIDGMS----- 418
             ++ LV      F+  A+N AG +   +    T I  +    P   LD T+ DG++     
Sbjct: 20335 VTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGD 20394

Query: 419   --VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
               V+ A    G P P  +W K  + +    +     TP  S  L I      DAG YT  
Sbjct: 20395 TIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSS-MLTIKYATRKDAGEYTIT 20453

Query: 477   ATNSRGVDEASADLVVW------ARTRITKPPQDQSVIKGTQ-----ASMVCGVTHDPRV 525
             ATN  G       + V           I+    +++ +  T       S +     + R 
Sbjct: 20454 ATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRE 20513

Query: 526   TIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG----GNDSRS 581
             T R +W      + +  H   +L +                Y  RV +      G   +S
Sbjct: 20514 TSRLLWTVVSEDIQSCRHVATKLIQGNE-------------YIFRVSAVNHYGKGEPVQS 20560

Query: 582   AHLRVRQL---PHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWT 637
               +++      P  PE P   +S V +    ++W +P D G S +  Y +E  E  +   
Sbjct: 20561 EPVKMVDRFGPPGPPEKP--EVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRW 20618

Query: 638   VLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP-PTAPPQN 696
             V             V GL    +Y+FR+ A N  G G  S+ ++ V + +   P  PP N
Sbjct: 20619 VRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 20678

Query: 697   VIASGRTNQSIMIQWQPPPESHQNGILK--GYIIRYCLAGLPVGYQFKNITDADVNNLLL 754
                +  T +S  + W  P   H +G L+  GY++ +   G     +    T   +   ++
Sbjct: 20679 PHVTDTTKKSASLAWGKP---HYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVV 20735

Query: 755   EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNA 814
              DL     Y   ++A N AG+G   + + +  +      P   + AE   +  +R     
Sbjct: 20736 PDLQTKEKYNFRISAINDAGVGE-PAVIPDVEIVEREMAPDFELDAELRRTLVVR----- 20789

Query: 815   PSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCF 874
                        G  +  + P +      VT     +D+I++   + ++  TE FT ++  
Sbjct: 20790 ----------AGLSIRIFVPIKGRPAPEVTWT---KDNINLKNRANIEN-TESFTLLII- 20834

Query: 875   TTPGDGPRSTPQLVRTHE---------------DVPGPVGHLSFSEILDTSLKVSWQEPG 919
               P      T + V T E               D PGPV +L  ++I   S+ + W  P 
Sbjct: 20835 --PECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPL 20892

Query: 920   EKNGI-LTGYRISWEEYNR----TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSK 974
                G  +T Y +   E  R    T T   H        Y+VTGL+    Y   V A    
Sbjct: 20893 IDGGSRITNYIVEKREATRKSYSTATTKCH-----KCTYKVTGLSEGCEYFFRVMAENEY 20947

Query: 975   GQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVG 1033
             G G+ + +T       E P PP +L I +I   +V+L + +P +DG + I+ +++EAQ  
Sbjct: 20948 GIGEPTETT-EPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRK 21006

Query: 1034  VVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ 1093
                  ++W  I  +          V +L     Y+F++  VN  G S             
Sbjct: 21007 ---GSDQWTHITTVKG----LECVVRNLTEGEEYTFQVMAVNSAGRS------------- 21046

Query: 1094  APPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESV-------GYKIKYSRSDGHGK 1146
             AP +  P  V  +T            LPE++  G  + +         K++         
Sbjct: 21047 APRESRPVIVKEQTM-----------LPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKP 21095

Query: 1147  TLSHVVQDRVERDYTIEDLEEW-TEYRVQVQAFNAIGSGPWSQT---VVGRTRESV---- 1198
             T++    D++ +     + E   T   + +       SGP+  T   +VG   + +    
Sbjct: 21096 TVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQV 21155

Query: 1199  -----PSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLV 1253
                  P +GP     ++  S  +   W + PE D    +  Y V  ++ DS T       
Sbjct: 21156 HDIPGPPTGPIKFDEVS--SDFVTFSW-DPPENDGGVPISNYVVEMRQTDSTTWVELATT 21212

Query: 1254  EGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEV 1312
                ++  A  T L   + Y+ +V A  R G G   +   I+      VPGPP       V
Sbjct: 21213 VIRTTYKA--TRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAV 21270

Query: 1313  RTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVY 1371
                S+ + W  P +  G  IL Y +  +           + L P    + ++GL     Y
Sbjct: 21271 TKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPG-NIFKSSGLTDGIAY 21329

Query: 1372  LFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQE-----------DVRARSVLL 1420
              FR+ A+   G              + +P  PS PM+  +           ++   +V L
Sbjct: 21330 EFRVIAENMAG--------------KSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTL 21375

Query: 1421  SW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKAT 1479
              W +P   G   +  Y ++ R+LP+GRW   + S +   + F V  L    +Y+FRV A 
Sbjct: 21376 KWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFS-NILENEFTVSGLTEDAAYEFRVIAK 21434

Query: 1480  NDIGD-SEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFR 1538
             N  G  S  SE S+++T       EAP I        T +L   +             FR
Sbjct: 21435 NAAGAISPPSEPSDAITCRDDV--EAPKIKVDVKFKDTVILKAGE------------AFR 21480

Query: 1539  IRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIR 1598
             +              + G   P   W++              +  +  + +NK       
Sbjct: 21481 LEA-----------DVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRR-D 21528

Query: 1599  MSVYNAVGEGPSSPPQEVFVGEAVPTAAPRN--VVVHGATATQLDVTWEPPPLDSQNGDI 1656
                Y      P    + +F  + +    P    + V   T+ +  ++W PP LD     I
Sbjct: 21529 SGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPP-LDDGGAKI 21587

Query: 1657  QGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTP 1714
               Y +   E  R   T     + + +  +K+  L     Y+  V A N  G G    S P
Sbjct: 21588 DHYIVQKRETSRLAWTNVASEVQVTK--LKVTKLLKGNEYIFRVMAVNKYGVGEPLESEP 21645

Query: 1715  TQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIV 1774
                      P  P + + + +T  S+ V W  P    G  E    + E         + +
Sbjct: 21646 VLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGS-EIINYIVERRDKAG--QRWI 21702

Query: 1775  TVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGA------PGPP 1828
               + K  + L  KV  L EG  Y FRI A+       I A   T P   A      PGPP
Sbjct: 21703 KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN---AAGISAPSPTSPFYKACDTVFKPGPP 21759

Query: 1829  GVPIIVRYS-SAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFS 1886
             G P ++  S S+I+I W+     G   IT Y++E    +E  W I+      + +SYT +
Sbjct: 21760 GNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTIT 21819

Query: 1887  MDILKPGVSYDFRVIAVNDYGFGTPS 1912
                L     Y  R+ A+N  G G P+
Sbjct: 21820 G--LTENQEYKIRIYAMNSEGLGEPA 21843



 Score =  201 bits (510), Expect = 8e-51
 Identities = 370/1602 (23%), Positives = 611/1602 (38%), Gaps = 215/1602 (13%)

Query: 412   TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
             TV  G +V L     G P P ++W+K   +L      +         +L +   +  D+G
Sbjct: 19306 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAE-GIKMAMQRNLCTLELFSVNRKDSG 19364

Query: 472   TYTCLATNSRGVDEASADLVVW------ARTRITKPPQDQSVIKGTQ-----ASMVCGVT 520
              YT  A NS G   A+  L V       A  +I K   D++++          S +    
Sbjct: 19365 DYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYI 19424

Query: 521   HDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSR 580
              D R T R  W +  AT+   S    +L                    C     G  D  
Sbjct: 19425 VDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFR----------ICAENKYGVGDPV 19474

Query: 581   SAHLRVRQLPHAP----EHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAP 635
                  + + P+ P    + PV  +S + +  + ++W  P D G SP+  Y+LE  E  A 
Sbjct: 19475 FTEPAIAKNPYDPPGRCDPPV--ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV 19532

Query: 636   -WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP--PTA 692
              WT +      + T +   GL     Y+FR+ A+N  G G+ S D  + +   +P  P  
Sbjct: 19533 NWTKVNRKPIIERT-LKATGLQEGTEYEFRVTAINKAGPGKPS-DASKAAYARDPQYPPG 19590

Query: 693   PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIR--------YCLAGLPVGYQFKNI 744
             PP        T  S+ + W  P     + I+ GY++         +    LP   Q    
Sbjct: 19591 PPAFPKVYDTTRSSVSLSWGKPAYDGGSPII-GYLVEVKRADSDNWVRCNLPQNLQK--- 19646

Query: 745   TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATN 804
             T  +V  L+ ED    T Y+  V A N  G    S    +   + +   P G + A+   
Sbjct: 19647 TRFEVTGLM-ED----TQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRK 19701

Query: 805   STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVT-ARPNFQDSIHVGFVSGLKK 863
             +  +R                G  +  + P +      +T ++PN      +G      K
Sbjct: 19702 TLILR---------------AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDI---K 19743

Query: 864   FTEYFTSVLC------------FTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSL 911
              T++ T + C             T      +    +V    D PGP  +++  EI   S 
Sbjct: 19744 STDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSA 19803

Query: 912   KVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA 970
              V+W+ P    G  +  Y +   +  R +        + T  +RV  L    +Y   V A
Sbjct: 19804 YVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT-SFRVANLEEGKSYFFRVFA 19862

Query: 971   MTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVE 1029
                 G G     T  +    + PGP  +L + ++   S ++ ++ P  DG + I  ++V+
Sbjct: 19863 ENEYGIGD-PGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVD 19921

Query: 1030  AQVGVVGEGEEWL-LIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
                  + E  +W  ++  LS +  A+     DL     Y+FR+   N  G   PS+    
Sbjct: 19922 ----FLTEENKWQRVMKSLSLQYSAK-----DLTEGKEYTFRVSAENENGEGTPSEI--- 19969

Query: 1089  IQTLQAPPDMAPANVSLR-------TASETSLW-----LRWMPLPEMEYNGNPESVGYKI 1136
               T+ A  D+   ++ L+        A E S +     ++  P P + +    + +    
Sbjct: 19970 --TVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDT 20027

Query: 1137  KYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGS--GPWSQTVVGRT 1194
             + S           V    V     + D ++    +  +   N  G+  G  S  VVG+ 
Sbjct: 20028 RVS-----------VESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKP 20076

Query: 1195  RESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVE 1254
                +P+ GP     +  T+ +M ++W+  P+ D    +  Y  + +++DS          
Sbjct: 20077 --GIPT-GPIKFDEV--TAEAMTLKWAP-PKDDGGSEITNY--ILEKRDSVNNKWVTCAS 20128

Query: 1255  GNSSRSAQLTGLGKYVLYEVQVLAFTR--IGDGSPSHPPILERTLD--DVPGPPMGILFP 1310
                  + ++T L + + Y  +V A  +  +G+G  S P +     D  D P PP  +   
Sbjct: 20129 AVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIV--- 20185

Query: 1311  EVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTT----ANTATVEVLAPSARQYTATGL 1365
             +VR  SV L W  P    G  I  Y +  +   +     AN   + +     R +  TGL
Sbjct: 20186 DVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRM-----RDFKVTGL 20240

Query: 1366  KPESVYLFRITAQTRKGWGEAA---EALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW 1422
                  Y FR+ A    G G+ +   E +V      D   PP +P V   ++   SV L W
Sbjct: 20241 TEGLEYEFRVMAINLAGVGKPSLPSEPVVAL----DPIDPPGKPEVI--NITRNSVTLIW 20294

Query: 1423  -EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATND 1481
              EP  DG   +  Y ++ R+LPS  W + +  V+    +F V  L     Y+FR++A N 
Sbjct: 20295 TEPKYDGGHKLTGYIVEKRDLPSKSW-MKANHVNVPECAFTVTDLVEGGKYEFRIRAKNT 20353

Query: 1482  IGDSEFSEESESLTTLQAAPD-EAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIR 1540
              G    S  SES  T+    + EAPTI+               P  +D       G  I+
Sbjct: 20354 AG--AISAPSESTETIICKDEYEAPTIVL-------------DPTIKD-------GLTIK 20391

Query: 1541  YRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL----SRPSLTQYELDNLNKHRRYE 1596
               + +   L   ++ G   P ++W++        ++    S P+ +   +    +    E
Sbjct: 20392 AGDTIV--LNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGE 20449

Query: 1597  IRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDI 1656
               ++  N  G    +  + V V        P  V +   +A +  +TW PP L+     I
Sbjct: 20450 YTITATNPFG----TKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP-LEDGGSPI 20504

Query: 1657  QGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTP 1714
             + Y +   E  R  L   V     +   V  K + G   Y+  V+A N  G G   +S P
Sbjct: 20505 KSYILEKRETSR-LLWTVVSEDIQSCRHVATKLIQG-NEYIFRVSAVNHYGKGEPVQSEP 20562

Query: 1715  TQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKI 1773
              +   +   P  P   + S +T  +  VSW+ P    G  + GY +       +  V  I
Sbjct: 20563 VKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 20622

Query: 1774  VTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGA--PGPPGV 1830
              T      S L  KV  L EG TY FR+ A+     GP  EA+ +    + A  PGPP  
Sbjct: 20623 KTPV----SDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 20678

Query: 1831  PIIVRYSSAIA-IHWSSGDPGKG-PITRYVIEARPSDEGLWDILIKDIPKEVSSYT-FSM 1887
             P +   +   A + W       G  IT YV+E +   +  W   IKD        T F +
Sbjct: 20679 PHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAW---IKDTTGTALRITQFVV 20735

Query: 1888  DILKPGVSYDFRVIAVNDYGFGTPS-SPSQSVPAQKANPFYE 1928
               L+    Y+FR+ A+ND G G P+  P   +  ++  P +E
Sbjct: 20736 PDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFE 20777



 Score =  200 bits (508), Expect = 1e-50
 Identities = 369/1617 (22%), Positives = 631/1617 (39%), Gaps = 210/1617 (12%)

Query: 477   ATNSRGVDEASADLVVWARTRITKPP-----QDQSVIKGTQASMVCGVTHDPRVTIRYIW 531
             A N+ GV + SA +      R   PP     +   V +GT  ++V  +   P  T+   W
Sbjct: 16093 AVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLT--W 16150

Query: 532   EKDGATLGTESHP--------RIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
              K          P        ++ +D   +L I Q+   D G YT   ++  G  S+   
Sbjct: 16151 FKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMR 16210

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLAS 642
             L V   P  P  P+    +V    + L+W  P D G S +  Y++E  E N    V ++S
Sbjct: 16211 LNVLGRPGPPVGPIK-FESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSS 16269

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTA--------PP 694
              +PK  + T+  L+    Y FR+ A N  G G+         L  EP TA         P
Sbjct: 16270 -EPKECTYTIPKLLEGHEYVFRIMAQNKYGIGE--------PLDSEPETARNLFSVPGAP 16320

Query: 695   QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL 754
                  S  T  S+ + W+ P E      + GY +           ++K +    +  + L
Sbjct: 16321 DKPTVSSVTRNSMTVNWEEP-EYDGGSPVTGYWLEMKDT---TSKRWKRVNRDPIKAMTL 16376

Query: 755   ------EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNST-- 806
                     LI  ++Y+  V A N+AG+G  S      T +  P  PPG    + T+ T  
Sbjct: 16377 GVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPPGPPFPKVTDWTKS 16435

Query: 807   TIRFTWNAP---SPQFINGINQGYKLIA---WEPEQEEEVTMVTARPNFQDSIHVGFVSG 860
             +    W+ P       + G    YK      WE  +++EV                 V+G
Sbjct: 16436 SADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL-----------VVTG 16484

Query: 861   LKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEP- 918
             LK+   Y   V      G G P     ++   + +  P          D  L  S ++  
Sbjct: 16485 LKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSP----------DLQLDASVRDRI 16534

Query: 919   -GEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVT-GLTALTTYTI---------E 967
                  G++   RI      +    VT  +   TL    T   TA+++  +          
Sbjct: 16535 VVHAGGVI---RIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQG 16591

Query: 968   VAAMTSKGQGQVSASTISSGVPPELPGPP-TNLGISNIGPRSVTLQ-FRPGYDGKTSISR 1025
             V ++ +K +      TI   V  ++PGP  T     N+   S  L  F P  DG + I+ 
Sbjct: 16592 VYSLLAKNEAGERKKTIIVDVL-DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITN 16650

Query: 1026  WLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP 1085
             +++E +     +   W  +       +A    V  L     Y FR+   N +G  P  + 
Sbjct: 16651 YVIEKRES---DRRAWTPVTYTVTRQNAT---VQGLIQGKAYFFRIAAENSIGMGPFVET 16704

Query: 1086  SRKIQTLQAPPDMA--PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDG 1143
             S  +  ++ P  +   P ++ ++  ++ ++ L W P    +Y+G  E + Y ++ SR  G
Sbjct: 16705 SEAL-VIREPITVPERPEDLEVKEVTKNTVTLTWNP---PKYDGGSEIINYVLE-SRLIG 16759

Query: 1144  HGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWS---QTVVGRTRESVPS 1200
               K       + + R YT++ L+E   Y  +V A N +G G  S   + +  +   + P+
Sbjct: 16760 TEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPT 16819

Query: 1201  ---SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDS-DTQPRFWLVEGN 1256
                     ++     + ++  R+S  P+   +       V+  ++    T P    +E  
Sbjct: 16820 LHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALE-- 16877

Query: 1257  SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG-ILFPEVRTT 1315
                 A+ +  GKY +          + + + S     +  + D PGPP+G + F EV   
Sbjct: 16878 -KIKAKRSDSGKYCVV---------VENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKD 16927

Query: 1316  SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESV-YLFR 1374
              + + W+PP    G  +   I  +          + V + SA+         E   Y+FR
Sbjct: 16928 YMVISWKPPLDDGGSKITNYIIEKKEV--GKDVWMPVTSASAKTTCKVSKLLEGKDYIFR 16985

Query: 1375  ITAQTRKGWGEAAEALVVTTEKRDR-PQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR 1433
             I A+   G  +   +  +  + R R P  P +P+V +  V   S L++W    DG  P+ 
Sbjct: 16986 IHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTE--VTKDSALVTWNKPHDGGKPIT 17043

Query: 1434  YYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESES 1493
              Y ++ RE  S RWA  +    H  + F V  L     Y+FRV A N+IG  + S  S+ 
Sbjct: 17044 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 17103

Query: 1494  LTTLQAAPDEAPTILSVTPHTT-TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGF 1552
             +         +P +      TT  SV + WQPP  D     +LG+ + Y+++  E  R  
Sbjct: 17104 VFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDG-GSKILGYIVEYQKVGDEEWR-- 17160

Query: 1553  TLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSS 1611
               R  + P                S P  T+Y++  L   + Y+ R+   NA GE  P+ 
Sbjct: 17161 --RANHTPE---------------SCPE-TKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 17202

Query: 1612  PPQEVFVGEAVPTAAPRNVVVHGATATQLDV-TWEPPPLDSQNGDIQGYKIYFWEAQRGN 1670
              P+ V V + +    P  +++    A +  +   +   L +    +   K+ + +  R  
Sbjct: 17203 VPEPVLVKDRL---EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDA 17259

Query: 1671  LTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSV 1730
              T+    +    + ++++N       + S+   N AG     T +        P  P  +
Sbjct: 17260 PTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGS---KTVSVKVLVLDKPGPPRDL 17316

Query: 1731  KFSELTTTSVNVSWEAP------QFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPL 1784
             + SE+   S  ++W+ P         N ++E   +     SP+   SK      K +   
Sbjct: 17317 EVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSK-----KKSHF-- 17369

Query: 1785  WLKVKDLAEGVTYRFRIRAKT-FTYGPEIEANVTTGPGEGAP--GPPGVPIIVRY----S 1837
                 K L EG  Y FR+ A+  +  GP +E   T  P +      PPG P  + +     
Sbjct: 17370 ---AKHLNEGNQYLFRVAAENQYGRGPFVE---TPKPIKALDPLHPPGPPKDLHHVDVDK 17423

Query: 1838  SAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSY 1896
             + +++ W+  D  G  PIT Y++E +  +EG  D +     K V++    +  L+ G +Y
Sbjct: 17424 TEVSLVWNKPDRDGGSPITGYLVEYQ--EEGTQDWIKF---KTVTNLECVVTGLQQGKTY 17478

Query: 1897  DFRVIAVNDYGFGTPSSPSQSVPAQKANPFYEEWWFLVVIALVGLIFI--LLLVFVLIIR 1954
              FRV A N  G G P +   ++P +           L V  + GL+      + F  IIR
Sbjct: 17479 RFRVKAENIVGLGLPDT---TIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIR 17535

Query: 1955  GQSKKYAKKTDSGNSAKSGALGHSEMMSLDESSFPALELNNRRLSVKNSFCRKNGLY 2011
             G     AK T  G+  K+      E  +++  +F ++      L++KN   R  G Y
Sbjct: 17536 GVPVPTAKWTTDGSEIKT-----DEHYTVETDNFSSV------LTIKNCLRRDTGEY 17581



 Score =  200 bits (508), Expect = 1e-50
 Identities = 379/1720 (22%), Positives = 629/1720 (36%), Gaps = 216/1720 (12%)

Query: 124   VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAIT-LENTLVILSTVAPDAGRYY 182
             V H    +     ++  P P VTW  + R +P  + I  T + +++VI +      G Y 
Sbjct: 16535 VVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYS 16594

Query: 183   VQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANAR 242
             + A N+     KT   I + V +V GP      T  +    T+     +  + E   +  
Sbjct: 16595 LLAKNEAGERKKT---IIVDVLDVPGPVG----TPFLAHNLTNESCKLTWFSPE--DDGG 16645

Query: 243   PLIKLHIIWKKDG---VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 299
               I  ++I K++           +   +  T+       A ++   A       P V   
Sbjct: 16646 SPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETS 16705

Query: 300   AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPP------PSITWYKDAAVVEVEK 353
               L + EP   +  PER    E+++V          PP        I +  ++ ++  EK
Sbjct: 16706 EALVIREP---ITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEK 16762

Query: 354   LTRFRQRN--DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL-- 409
               +    N       + GL   DT  ++  A N  G+ + S      +    +    L  
Sbjct: 16763 FHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHL 16822

Query: 410   ----DSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT 465
                   T+  G +  L    SG P+P ++W K E  +        + TP       I   
Sbjct: 16823 DFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAK 16882

Query: 466   HISDAGTYTCLATNSRG----------------------VDEASADLVVWARTRITKPPQ 503
               SD+G Y  +  NS G                       DE + D +V +     KPP 
Sbjct: 16883 R-SDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVIS----WKPPL 16937

Query: 504   DQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGD 563
             D         S +     + +   + +W     +   ++  ++     G  +I +  + +
Sbjct: 16938 DDG------GSKITNYIIEKKEVGKDVW-MPVTSASAKTTCKVSKLLEGKDYIFRIHAEN 16990

Query: 564   IGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLI 623
             +   +  ++S    DS  A  R R +P AP+ P+ T   V + +  +TW KP DG  P+ 
Sbjct: 16991 LYGISDPLVS----DSMKAKDRFR-VPDAPDQPIVT--EVTKDSALVTWNKPHDGGKPIT 17043

Query: 624   RYILEMSEN-NAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTER 682
              YILE  E  +  W  +        T   V  L+    Y+FR+ A N++G G  S  ++ 
Sbjct: 17044 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 17103

Query: 683   VSLPEE-PPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF 741
             V   +     +PP N  A   T  S+ + WQPP     + IL GYI+ Y   G     + 
Sbjct: 17104 VFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKIL-GYIVEYQKVGDEEWRRA 17162

Query: 742   KNITDA-DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNV-H 799
              +  ++       +  L     Y+  V A N+AG     + V E  L      PP  +  
Sbjct: 17163 NHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGES-DPAHVPEPVLVKDRLEPPELILD 17221

Query: 800   AEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVS 859
             A       I+          I G+   +  + W+ E  +  T         D   VG   
Sbjct: 17222 ANMAREQHIKVGDTLRLSAIIKGV--PFPKVTWKKEDRDAPTKARI-----DVTPVGSKL 17274

Query: 860   GLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPG 919
              ++        +   T        T  +     D PGP   L  SEI   S  ++W+EP 
Sbjct: 17275 EIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPL 17334

Query: 920   EKNG-ILTGYRI--------SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA 970
             +  G ++T Y +         W   + T+ + +H+  +         L     Y   VAA
Sbjct: 17335 DDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH---------LNEGNQYLFRVAA 17385

Query: 971   MTSKGQGQV--SASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWL 1027
                 G+G    +   I +  P   PGPP +L   ++    V+L + +P  DG + I+ +L
Sbjct: 17386 ENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYL 17445

Query: 1028  VEAQVGVVGEG-EEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTS-PPSQP 1085
             VE Q     EG ++W+    ++N        V  L     Y FR++  NIVG   P +  
Sbjct: 17446 VEYQ----EEGTQDWIKFKTVTN----LECVVTGLQQGKTYRFRVKAENIVGLGLPDTTI 17497

Query: 1086  SRKIQTLQAPPD-------MAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY 1138
               + Q    PP        +    V   T       +R +P+P  ++  +   +      
Sbjct: 17498 PIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI------ 17551

Query: 1139  SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESV 1198
              ++D H      V  D      TI++         Q+   NA GS       V  T   V
Sbjct: 17552 -KTDEH----YTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGS---KTVAVHLTVLDV 17603

Query: 1199  PS--SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLV--E 1254
             P   +GP N+  L  T   M + W + P+ D    V+ Y V    +  DT+   W V   
Sbjct: 17604 PGPPTGPINI--LDVTPEHMTISW-QPPKDDGGSPVINYIV----EKQDTRKDTWGVVSS 17656

Query: 1255  GNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVR 1313
             G+S    ++  L K   Y  +V A  +IG G P    P + +     P PP   +  ++ 
Sbjct: 17657 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 17716

Query: 1314  TTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYL 1372
               +  + W  P +  G  I  Y +  R    T     V     +  ++  TGL   + Y 
Sbjct: 17717 ENAATVSWTLPKSDGGSPITGYYMERR--EVTGKWVRVNKTPIADLKFRVTGLYEGNTYE 17774

Query: 1373  FRITAQTRKGWGEAAEAL--VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLS 1430
             FR+ A+   G  + + +   +        P PP  P ++ +  R  + L+  +P SDG S
Sbjct: 17775 FRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKS-RETADLVWTKPLSDGGS 17833

Query: 1431  PVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEE 1490
             P+  Y ++ ++  + +W   +        +F V  L     Y+FR+KA N +G+ E  E 
Sbjct: 17834 PILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPREL 17893

Query: 1491  SESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLR 1550
             +ES+         A  IL   P     V  R        +  + +G  IR          
Sbjct: 17894 AESVI--------AKDILH-PPEVELDVTCR-------DVITVRVGQTIRILA------- 17930

Query: 1551  GFTLRGINNPGATWAELTSMY-------SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYN 1603
                ++G   P  TW +   +         +++L R  L   E    + H +Y I  S  N
Sbjct: 17931 --RVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRAD-HGKYII--SAKN 17985

Query: 1604  AVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYF 1663
             + G    S      V         +N+ V   T     ++WE  PLD+   +I  + + +
Sbjct: 17986 SSGHAQGS----AIVNVLDRPGPCQNLKVTNVTKENCTISWE-NPLDNGGSEITNFIVEY 18040

Query: 1664  -------WEAQRGNLTER-VKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP---RS 1712
                    W     ++T+R +K   LA N            Y   V A N  G GP     
Sbjct: 18041 RKPNQKGWSIVASDVTKRLIKANLLANNE-----------YYFRVCAENKVGVGPTIETK 18089

Query: 1713  TPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
             TP         P  P ++  ++   T V + W  P +  G
Sbjct: 18090 TPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGG 18129



 Score =  198 bits (503), Expect = 5e-50
 Identities = 328/1450 (22%), Positives = 557/1450 (38%), Gaps = 178/1450 (12%)

Query: 523   PRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA 582
             P+VT    W K G            +D    L I  +   D G Y+  +++  G  +   
Sbjct: 18636 PKVT----WRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFV 18691

Query: 583   HLRVRQLPHAPEHPVATL--STVERRAINLTWTKPF-DGNSPLIRYILEMSE-NNAPWTV 638
             ++RV   P     PV+ L  S V + + +++W  P  DG S +  YI+E  E +   W+ 
Sbjct: 18692 NVRVLDTPG----PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWST 18747

Query: 639   LLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTA--PPQN 696
             +   V  K TS  V  LVP   Y FR+ AVN+ G G    D  +  L  +P +   PP+ 
Sbjct: 18748 VTPEV--KKTSFHVTNLVPGNEYYFRVTAVNEYGPG-VPTDVPKPVLASDPLSEPDPPRK 18804

Query: 697   VIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLED 756
             +  +  T  S  + W PP        + GYI  Y     P     +     D+ +L++  
Sbjct: 18805 LEVTEMTKNSATLAWLPPLRD-GGAKIDGYITSYREEEQPADRWTEYSVVKDL-SLVVTG 18862

Query: 757   LIIWTNYEIEVAAYNSAGL-------GVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIR 809
             L     Y+  VAA N+ G+       GVY +K     L     + P  +  +A     I 
Sbjct: 18863 LKEGKKYKFRVAARNAVGVSLPREAEGVYEAKE---QLLPPKILMPEQITIKAGKKLRIE 18919

Query: 810   -FTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYF 868
                +  P P              W+  ++E VT      +  DS  +  +  + +    +
Sbjct: 18920 AHVYGKPHP-----------TCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGY 18968

Query: 869   TSVLCFTTPGDGPRSTPQLVRTHEDVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LT 926
              S+    + G   +    +V    D PG P      S+I   +  +SW  P E  G  +T
Sbjct: 18969 YSLTAENSSGTDTQKIKVVVM---DAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 19025

Query: 927   GYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTIS 985
              Y +   + +R +  VT          RV  L     Y   V A    G  + +++  + 
Sbjct: 19026 NYIVEKCDVSRGDW-VTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMV 19084

Query: 986   SGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLI 1044
             +  P  +P  P N  ++ +    + + + RP  DG + I  +L+E +       E   L+
Sbjct: 19085 AQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERK-------ERNSLL 19137

Query: 1045  HQLSNEPDARSMEVP--DLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQT-LQAPPDMAPA 1101
                +N+   RS E P   L     YSFR+  +N  G+SPPS+P+  +   +   P   P 
Sbjct: 19138 WVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPE 19197

Query: 1102  NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV-ERDY 1160
              + +  ++ + +W R       +++G  + +GY ++  +  G      +    ++ + +Y
Sbjct: 19198 VIDVTKSTVSLIWAR------PKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEY 19251

Query: 1161  TIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRW 1220
             T   LEE  +Y+ +  A  A+   P S+     T   +  + P  +       S + V+ 
Sbjct: 19252 TATGLEEKAQYQFRAIARTAVNISPPSEPSDPVT--ILAENVPPRIDLSVAMKSLLTVKA 19309

Query: 1221  SEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG-KYVLYEVQVLAF 1279
                       + L   V  K   + +    W  +G   + A+   +  +  L  +++ + 
Sbjct: 19310 G-------TNVCLDATVFGKPMPTVS----WKKDGTLLKPAEGIKMAMQRNLCTLELFSV 19358

Query: 1280  TRIGDG---------SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI 1330
              R   G         S S    ++  + D PGPP  +   ++ +    L W+PP    G 
Sbjct: 19359 NRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGS 19418

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAA-EA 1389
              +   I  +  T+  N A V    P     +   L     Y FRI A+ + G G+     
Sbjct: 19419 EITNYIVDKRETSRPNWAQVSATVP-ITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTE 19477

Query: 1390  LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWA 1448
               +     D P     P++   ++    + +SW+ P  DG SP+  Y ++ RE  +  W 
Sbjct: 19478 PAIAKNPYDPPGRCDPPVI--SNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWT 19535

Query: 1449  LHSASVSHNASSFIVDR------LKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA-P 1501
               +          I++R      L+  T Y+FRV A N  G  + S+ S++        P
Sbjct: 19536 KVNRKP-------IIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYP 19588

Query: 1502  DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
                P    V   T +SV + W  PA D  + I+                G+ +       
Sbjct: 19589 PGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPII----------------GYLVEVKRADS 19632

Query: 1562  ATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVG-EGPSSPPQE----- 1615
               W       +++       T++E+  L +  +Y+ R+   N +G   PS  P +     
Sbjct: 19633 DNWVRCNLPQNLQK------TRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKD 19686

Query: 1616  -VFVGEAVPTAAPRNVVVHGATATQ---LDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNL 1671
              +   E    A  R  ++  A  T    + V   PPP           KI  W     NL
Sbjct: 19687 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPP-----------KI-TWSKPNVNL 19734

Query: 1672  TERV-----KTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSA 1726
              +R+      T F  +  ++ +N+  Y A    +   N+ G   +   T        P  
Sbjct: 19735 RDRIGLDIKSTDF--DTFLRCENVNKYDAGKYILTLENSCG---KKEYTIVVKVLDTPGP 19789

Query: 1727  PSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWL 1786
             P +V   E++  S  V+WE P    G      +V +  +     S + T   K +     
Sbjct: 19790 PVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS----F 19845

Query: 1787  KVKDLAEGVTYRFRIRAKT-FTYGPEIEANVTTGPGEGAPGPPGVPIIVR--YSSAIAIH 1843
             +V +L EG +Y FR+ A+  +  G   E        +  PGP  V + VR    S+ +I 
Sbjct: 19846 RVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ-TPGPV-VDLKVRSVSKSSCSIG 19903

Query: 1844  WSS-GDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
             W      G   I  YV++   ++E  W  ++K +     S  +S   L  G  Y FRV A
Sbjct: 19904 WKKPHSDGGSRIIGYVVDFL-TEENKWQRVMKSL-----SLQYSAKDLTEGKEYTFRVSA 19957

Query: 1903  VNDYGFGTPS 1912
              N+ G GTPS
Sbjct: 19958 ENENGEGTPS 19967



 Score =  195 bits (495), Expect = 5e-49
 Identities = 428/1972 (21%), Positives = 746/1972 (37%), Gaps = 272/1972 (13%)

Query: 76    YMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAP 135
             ++++ L      F+R    N+ G    R+  + V      E  E            +RA 
Sbjct: 26432 HVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAG 26491

Query: 136   R-------IASFPQPQVTWFRDGRKIPPSSRI--AITLEN-TLVILSTVAPDAGRYYVQA 185
                     I+  P P+VT  RDG  +  + R    IT EN T+ +  +V  DAGRY + A
Sbjct: 26492 SNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITA 26551

Query: 186   VNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVA--------GTSEVTLEC 237
              N       T   I + V +  GP  P  P +I      SV          G S+VT   
Sbjct: 26552 ANSSG---TTKAFINIVVLDRPGP--PTGPVVISDITEESVTLKWEPPKYDGGSQVTNYI 26606

Query: 238   VANARPLIKLHIIWKKDGVLLSGGI---------SDHNRRLTIPNPTG-SDAGYYECEAV 287
             +           +W +    ++  +          ++  R+   N  G SD     C  V
Sbjct: 26607 LLKRETSTA---VWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTV 26663

Query: 288   LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
                 + P      +++ +            ++     VV    + K     SI W K   
Sbjct: 26664 KLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKD--RNSILWQKANK 26721

Query: 348   VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTS--------------- 392
             +V   + T F+         +GL+ +    F+ +A NAAG  + S               
Sbjct: 26722 LVI--RTTHFKVTTIS----AGLIYE----FRVYAENAAGVGKPSHPSEPVLAIDACEPP 26771

Query: 393   TYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRF 452
               + +T I+ N           DG S +          P   W K              F
Sbjct: 26772 RNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKAS------------F 26819

Query: 453   TPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV-------VWARTRITKPPQDQ 505
             T +     +IS    +    +   A N+ G     +++V        +    I  P +  
Sbjct: 26820 TNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYT 26879

Query: 506   SVIK---GTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQTWS 561
              V+K   GT   +  G++  P  TI   W KD   L T +   +    +  S+ I     
Sbjct: 26880 EVVKYRAGTSVKLRAGISGKPAPTIE--WYKDDKELQTNALVCVENTTDLASILIKDADR 26937

Query: 562   GDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNS 620
              + G Y  ++ +A G+ S +  +++   P  P  P+    TV    I L W  P D G +
Sbjct: 26938 LNSGCYELKLRNAMGSASATIRVQILDKPGPPGGPIE-FKTVTAEKITLLWRPPADDGGA 26996

Query: 621   PLIRYILEMSENN-APWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKD 679
              +  YI+E  E +   W+++   ++     +T   ++    Y FR+ AVN  G G+  + 
Sbjct: 26997 KITHYIVEKRETSRVVWSMVSEHLEE--CIITTTKIIKGNEYIFRVRAVNKYGIGEPLES 27054

Query: 680   TERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYII----RYCLAGL 735
                V+        PP     +  T  S+ + W  P     + I  GY +    +  L   
Sbjct: 27055 DSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDI-SGYFLEKRDKKSLGWF 27113

Query: 736   PVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPP 795
              V  +    T   V  L        ++Y+  V A N+AG G +S   +E+     P  PP
Sbjct: 27114 KVLKETIRDTRQKVTGLTEN-----SDYQYRVCAVNAAGQGPFSEP-SEFYKAADPIDPP 27167

Query: 796   G---NVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDS 852
             G    +    +  ++I   W+ P     + +  GY ++     +EEE T V+ +   + +
Sbjct: 27168 GPPAKIRIADSTKSSITLGWSKPVYDGGSAVT-GY-VVEIRQGEEEEWTTVSTKGEVRTT 27225

Query: 853   IHVGFVSGLKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFSEI-LDTS 910
              +V  VS LK    Y+  V      G G P    + V+  + +  P       EI LD +
Sbjct: 27226 EYV--VSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAP-------EIDLDVA 27276

Query: 911   LKVSW-QEPGEKNGILTGYR------ISWEEYNRTNTRVTHY-LPNVTLEYRVTGLTALT 962
             L+ S   + GE   +L  ++      ++W +  +       Y + N      +T      
Sbjct: 27277 LRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTR 27336

Query: 963   TYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKT 1021
               T +       G G+  +ST+S  V  + P     L + ++   +VTL + P   DG +
Sbjct: 27337 NDTGKYILTIENGVGEPKSSTVSVKVL-DTPAACQKLQVKHVSRGTVTLLWDPPLIDGGS 27395

Query: 1022  SISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSP 1081
              I  +++E +         W ++   S++  + S ++ DL+  T + FR+   N +G   
Sbjct: 27396 PIINYVIEKRDATK---RTWSVV---SHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGE 27449

Query: 1082  PSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRS 1141
             P + +  ++  + P  +   ++S++ +++TS+ L W    + +++G      Y ++  R 
Sbjct: 27450 PCETTEPVKAAEVPAPIR--DLSMKDSTKTSVILSWT---KPDFDGGSVITEYVVE--RK 27502

Query: 1142  DGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESVPS 1200
                 +T SH    +   +  +  L+E +    +V A N  G S P              +
Sbjct: 27503 GKGEQTWSHAGISKT-CEIEVSQLKEQSVLEFRVFAKNEKGLSDP-------------VT 27548

Query: 1201  SGPTNVSALATTSSSMLVRWSEVPEAD---RNGLVLGYKVMYKEKDSDTQPRFWLVEGNS 1257
              GP  V  L  T     V  S++P A    R G  +  ++ YK K   +    WL +G  
Sbjct: 27549 IGPITVKELIITPE---VDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSIS--WLKDGLP 27603

Query: 1258  SRSAQLTGLGKY---VLYEVQVLA------FTRIGDGSPSH--PPILERTLDDVPGPPMG 1306
              + ++     K    +   ++         +T I D +      PI   TL     P   
Sbjct: 27604 LKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGP 27663

Query: 1307  ILFPEVRTTSVRLIWQPPAAPNG-IILAYQITHRLNTTTANTATVEVLAPSARQ-YTATG 1364
             I F E++  SV L W  P    G  I  Y I  R    T+ T    V +  AR  +    
Sbjct: 27664 IRFDEIKADSVILSWDVPEDNGGGEITCYSIEKR---ETSQTNWKMVCSSVARTTFKVPN 27720

Query: 1365  LKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDR-PQPPSRPMVQQEDVRARSVLLSWE 1423
             L  ++ Y FR+ A+ R G  +   + ++  + + R P PP +P++   +V +  + L+W+
Sbjct: 27721 LVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY--NVTSDGMSLTWD 27778

Query: 1424  -PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDI 1482
              P  DG S V  + ++ +E  S  W   + S   +   +    L     Y+FRV A N  
Sbjct: 27779 APVYDGGSEVTGFHVEKKERNSILWQKVNTSPI-SGREYRATGLVEGLDYQFRVYAENSA 27837

Query: 1483  GDSEFSEESE-SLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY 1541
             G S  S+ S+ +L      P   P  + VT  T T   ++W PP  D  + I+ G+ I  
Sbjct: 27838 GLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETIT---LKWNPPLRDGGSKIV-GYSIEK 27893

Query: 1542  RELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSV 1601
             R+                    W          N +  S  QY +  L+   RYE R+  
Sbjct: 27894 RQ----------------GNERWVRC-------NFTDVSECQYTVTGLSPGDRYEFRIIA 27930

Query: 1602  YNAVGEGPSSPPQE-----VFVGEAVPTAAP------RNVVVHGATATQLDVTWEPPPLD 1650
              NAVG    SPP +     +   E VP            +++    + ++    +  P+ 
Sbjct: 27931 RNAVGT--ISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP 27988

Query: 1651  SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710
                    G +I     +R N+     T  L   S+ +++ T     + +V A NA+G   
Sbjct: 27989 RVTWFKDGVEI----EKRMNMEI---TDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAK 28041

Query: 1711  RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGV 1770
                  + Q        P  ++F+ +T   + + W+AP            + + C+P+   
Sbjct: 28042 AEIKVKVQDTPGKVVGP--IRFTNITGEKMTLWWDAP------------LNDGCAPITHY 28087

Query: 1771  SKIVTVDVKGNSPL-WLKVKDLAE-----------GVTYRFRIRA-KTFTYGPEIEANVT 1817
                  ++ +  S L W  ++D  E           G  Y+FR+ A   F  G  ++++  
Sbjct: 28088 ----IIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPV 28143

Query: 1818  TGPGE-GAPGPPGVPIIVRYS-SAIAIHWSSGDP-GKGPITRYVIEARPSDEGLWDILIK 1874
                 +   P  PG+P     + ++I + W+  +  G   I +Y++E R      W  +I 
Sbjct: 28144 VAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVIS 28203

Query: 1875  DIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQK-ANP 1925
               P  +S   F +  L  G  Y+F V+A N  G G  S  S+ +  ++  NP
Sbjct: 28204 KRP--ISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNP 28253



 Score =  193 bits (490), Expect = 2e-48
 Identities = 350/1604 (21%), Positives = 572/1604 (35%), Gaps = 169/1604 (10%)

Query: 378   FQCFARNAAGEVQTSTYLAVTS---IAPNIT-RGPLDSTVI--DGMSVVLACETSGAPRP 431
             F+  A N  GE   S    V     +AP++  +G  D   +  +  +  L     G P P
Sbjct: 19953 FRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAP 20012

Query: 432   AITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV 491
             +++W+KGE  LA+   ++   +   + +L++     SDAG YT    N  G  E +  + 
Sbjct: 20013 SVSWKKGEDPLAT-DTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIK 20071

Query: 492   VWARTRITKPPQDQSVIKGTQASMVCGVTHDP--RVTIRYIWEK----DGATLGTESHPR 545
             V  +  I   P     +     ++      D        YI EK    +   +   S  +
Sbjct: 20072 VVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQ 20131

Query: 546   IRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVER 605
                 R   LH    ++  +       +  G             +P AP  P   +  V  
Sbjct: 20132 KTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAP--PPPNIVDVRH 20189

Query: 606   RAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFR 664
              +++LTWT P   G SP+  Y LE  E N+           +     V GL     Y+FR
Sbjct: 20190 DSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFR 20249

Query: 665   LCAVNDVGKGQFSKDTERVSLPEEP-----PTAPPQNVIASGRTNQSIMIQWQPPPESHQ 719
             + A+N  G G       + SLP EP     P  PP        T  S+ + W  P   + 
Sbjct: 20250 VMAINLAGVG-------KPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEP--KYD 20300

Query: 720   NG-ILKGYIIRYCLAGLPVGYQFK-NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGV 777
              G  L GYI+      LP     K N  +       + DL+    YE  + A N+AG   
Sbjct: 20301 GGHKLTGYIVE--KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAIS 20358

Query: 778   YSSKVTEW----------TLQGVPTVPPG-NVHAEATNSTTIRFTWNAPSPQFINGINQG 826
               S+ TE           T+   PT+  G  + A  T           P P+  +  ++ 
Sbjct: 20359 APSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPK--SSWSKA 20416

Query: 827   YKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQ 886
              K I     +  ++T +T+ P          +  +K  T         T           
Sbjct: 20417 GKDI-----RPSDITQITSTP-------TSSMLTIKYATRKDAGEYTITATNPFGTKVEH 20464

Query: 887   LVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHY 945
             +  T  DVPGP G +  S +      ++W  P E  G  +  Y +   E +R    V   
Sbjct: 20465 VKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSE 20524

Query: 946   LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPTNLGISNI 1004
                 +  +  T L     Y   V+A+   G+G+ V +  +        PGPP    +SN+
Sbjct: 20525 -DIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNV 20583

Query: 1005  GPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNP 1063
                + T+ + RP  DG + I+ + VE +     E +    +  +         +V  L  
Sbjct: 20584 TKNTATVSWKRPVDDGGSEITGYHVERR-----EKKSLRWVRAIKTPVSDLRCKVTGLQE 20638

Query: 1064  FTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAP-PDMAPANVSLRTASETSLWLRWMPLPE 1122
              + Y FR+   N  G  PPS+ S  +    A  P   P+N  +   ++ S  L W    +
Sbjct: 20639 GSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAW---GK 20695

Query: 1123  MEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182
               Y+G  E  GY +++ +                   + + DL+   +Y  ++ A N  G
Sbjct: 20696 PHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG 20755

Query: 1183  SGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEK 1242
              G   +  V    E V      +    A    +++VR             L  ++    K
Sbjct: 20756 VG---EPAVIPDVEIVEREMAPDFELDAELRRTLVVRAG-----------LSIRIFVPIK 20801

Query: 1243  DSDTQPRFWLVEG-NSSRSAQLTGLGKYVL--------YEVQVLAFTRIGDGSPSHPPIL 1293
                     W  +  N    A +     + L        Y+      T           + 
Sbjct: 20802 GRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVN 20861

Query: 1294  ERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVL 1353
              R L D PGP + +   ++   SV L W  P    G  +   I  +   T  + +T    
Sbjct: 20862 VRVL-DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTK 20920

Query: 1354  APSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRP-MVQQED 1412
                   Y  TGL     Y FR+ A+   G GE  E    TTE     + PS P  +   D
Sbjct: 20921 CHKC-TYKVTGLSEGCEYFFRVMAENEYGIGEPTE----TTEPVKASEAPSPPDSLNIMD 20975

Query: 1413  VRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTS 1471
             +   +V L+W +P  DG S +  Y I+ +   S +W  H  +V       +V  L     
Sbjct: 20976 ITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWT-HITTV--KGLECVVRNLTEGEE 21032

Query: 1472  YKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKIN 1531
             Y F+V A N  G S                          P  +  V+++ Q    +   
Sbjct: 21033 YTFQVMAVNSAGRS-------------------------APRESRPVIVKEQTMLPE--- 21064

Query: 1532  GILLGFRIRYRELLY----EGLR-GFTLRGINNPGATWAELTSMYSM-RNLSRPSLTQYE 1585
                L  R  Y++L+     + ++    + G   P  TW +   +    + ++  +     
Sbjct: 21065 ---LDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATST 21121

Query: 1586  LDNLNKHRRYE---IRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 1642
             + N+N+  R +     ++  N VGE       +V      PT     +     ++  +  
Sbjct: 21122 ILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGP---IKFDEVSSDFVTF 21178

Query: 1643  TWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAA 1702
             +W+PP  D     I  Y +   +       E   T+     + K   LT    Y   V A
Sbjct: 21179 SWDPPENDG-GVPISNYVVEMRQTDSTTWVELATTVI--RTTYKATRLTTGLEYQFRVKA 21235

Query: 1703  FNAAGDGPRSTPT--QGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRL 1759
              N  G GP  T            P  P + + + +T  S+ +SW  P    G  + GY +
Sbjct: 21236 QNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHV 21295

Query: 1760  VYEPCSPV--DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVT 1817
               +  + +    VSK +   V GN     K   L +G+ Y FR+ A+      +      
Sbjct: 21296 ERKERNGILWQTVSKAL---VPGNI---FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE 21349

Query: 1818  TGPGEGAPGPPGVPIIVRYS-SAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKD 1875
                      PPG P+ +  +   + + W+  +  G   IT Y++E R    G W   +K 
Sbjct: 21350 PMLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRW---LKA 21406

Query: 1876  IPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG-FGTPSSPSQSV 1918
                 +    F++  L    +Y+FRVIA N  G    PS PS ++
Sbjct: 21407 NFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAI 21450



 Score =  193 bits (490), Expect = 2e-48
 Identities = 343/1510 (22%), Positives = 596/1510 (39%), Gaps = 171/1510 (11%)

Query: 473   YTCLATNSRG-VDEASADLVVWARTRITKPP-----QDQSVIKGTQASMVCGVTHDPRVT 526
             +  +A N +G  D  S  + + A+  + +P         SV  G    +   ++  P+ T
Sbjct: 23201 FRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPT 23260

Query: 527   IRYIWEKDGATLGTESHPRIR--LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHL 584
             I   W KDG  L   +   +   LD   +L I +T   D G Y   V +  G  + S  +
Sbjct: 23261 IT--WTKDGLPLKQTTRINVTDSLDLT-TLSIKETHKDDGGQYGITVANVVGQKTASIEI 23317

Query: 585   RVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP-WTVLLAS 642
                  P  P+ PV     V   +I L+W  P + G   +  YI++  +     W V+ A+
Sbjct: 23318 VTLDKPDPPKGPVK-FDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSAT 23376

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERV--SLPEEPPTAPPQNVIAS 700
             V    T++ V  L     YQFR+ A N  G+  F+ +++ +    P + P  PP    A+
Sbjct: 23377 V--ARTTLKVTKLKTGTEYQFRIFAENRYGQS-FALESDPIVAQYPYKEP-GPPGTPFAT 23432

Query: 701   GRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLED---- 756
               +  S++IQW  P  +  + ++  ++ R          +  +I    VN  ++ D    
Sbjct: 23433 AISKDSMVIQWHEPVNNGGSPVIGYHLERK---------ERNSILWTKVNKTIIHDTQFK 23483

Query: 757   ---LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWN 813
                L     YE  V A N  G+G  +SK +E  +   P  PPG           I   W 
Sbjct: 23484 AQNLEEGIEYEFRVYAENIVGVGK-ASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 23542

Query: 814   APSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVL 872
              P        + G  +  +  E+ +       + +F + I   F VSGL +   Y   V+
Sbjct: 23543 KPV------YDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVI 23596

Query: 873   CFTTPG--DGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRI 930
                  G    P  +   +   ++V  P   +S       ++ V+  E       + G  +
Sbjct: 23597 AKNAAGAISKPSDSTGPITAKDEVELP--RISMDPKFRDTIVVNAGETFRLEADVHGKPL 23654

Query: 931   SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI--SSGV 988
                E+ R +  +     +   E + T   AL    ++ A     GQ  + AS +  S   
Sbjct: 23655 PTIEWLRGDKEIEE---SARCEIKNTDFKALLI--VKDAIRIDGGQYILRASNVAGSKSF 23709

Query: 989   PPEL-----PGPPTN-LGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVGVVGEGEEW 1041
             P  +     PGPP   + ++ +     +L + P   DG + IS ++VE +         W
Sbjct: 23710 PVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRET---SRLAW 23766

Query: 1042  LLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPA 1101
              ++   ++E    S++V  L     Y FR+  VN  G   P + +  +          P 
Sbjct: 23767 TVV---ASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPK 23823

Query: 1102  NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV-ERDY 1160
             ++ +   ++ S+ + W      + +G  E +GY ++  + D  G       + R+ +   
Sbjct: 23824 SLEVTNIAKDSMTVCWN---RPDSDGGSEIIGYIVE--KRDRSGIRWIKCNKRRITDLRL 23878

Query: 1161  TIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGP-TNVSALATTSSSMLV 1218
              +  L E  EY  +V A NA G G P   TV  +  + V   GP TN   + TT +S+ +
Sbjct: 23879 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 23938

Query: 1219  RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA 1278
              W + P  D    +LGY V   + D +         G      +++ L ++  Y+++V A
Sbjct: 23939 AWGK-PIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCA 23997

Query: 1279  FTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITH 1338
               ++G G  +  P   +  D +  P +  L  E+R               GI++    + 
Sbjct: 23998 LNKVGLGEATSVPGTVKPEDKLEAPELD-LDSELR--------------KGIVVRAGGSA 24042

Query: 1339  RLNTTTANTATVEVL-APSARQYTATGLKPESVYLFRITAQT--RKGWGE---------A 1386
             R++       T E+  +    ++T      + V   +++     R   G+          
Sbjct: 24043 RIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG 24102

Query: 1387  AEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSG 1445
             +++  VT +  D P PP    V++  VR  S  L WEP   DG + V+ Y I  RE  S 
Sbjct: 24103 SKSAFVTVKVLDTPGPPQNLAVKE--VRKDSAFLVWEPPIIDGGAKVKNYVIDKRE--ST 24158

Query: 1446  RWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAP 1505
             R A  + S   + +SF V+ L     Y FRV A N+ G     E  +++    A P   P
Sbjct: 24159 RKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKA--AEPPSPP 24216

Query: 1506  TILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWA 1565
               +++T  + TS  + W+ P  D  + +L G+ +   E+  +G   +++           
Sbjct: 24217 GKVTLTDVSQTSASLMWEKPEHDGGSRVL-GYVV---EMQPKGTEKWSI----------- 24261

Query: 1566  ELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVP-- 1623
                       ++   +    +  L+  + Y+ R+  YN  G+   S P+ + V       
Sbjct: 24262 ----------VAESKVCNAVVTGLSSGQEYQFRVKAYNEKGK---SDPRVLGVPVIAKDL 24308

Query: 1624  TAAPRNVVVHGATATQL--DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLA 1681
             T  P   +     + Q   D+  E P +     +I   K    + +    T RV     A
Sbjct: 24309 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVK----DGEPLKQTTRVNVEETA 24364

Query: 1682  ENSV---KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
              ++V   K  N   +  Y  +V A N+AG    +       +   P  P  V+F E++  
Sbjct: 24365 TSTVLHIKEGNKDDFGKY--TVTATNSAGTATENLSVIVLEKPGPPVGP--VRFDEVSAD 24420

Query: 1739  SVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTY 1797
              V +SWE P +  G  +  Y  + E          +V+  V   +   +K+  L  G  Y
Sbjct: 24421 FVVISWEPPAYTGGCQISNY--IVEKRDTTTTTWHMVSATVARTT---IKITKLKTGTEY 24475

Query: 1798  RFRIRAKTFTYGP----EIEANVTTGPGEGAPGPPGVPIIVRYSS-AIAIHWSSG-DPGK 1851
             +FRI A+   YG     + +A +   P +  PGPPG P +   S   + + W    + G 
Sbjct: 24476 QFRIFAEN-RYGKSAPLDSKAVIVQYPFK-EPGPPGTPFVTSISKDQMLVQWHEPVNDGG 24533

Query: 1852  GPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP 1911
               I  Y +E +  +  LW  L K   ++    T  +D    G+ Y+F+V A N  G G P
Sbjct: 24534 TKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLD---EGLEYEFKVSAENIVGIGKP 24590

Query: 1912  SSPSQSVPAQ 1921
             S  S+   A+
Sbjct: 24591 SKVSECFVAR 24600



 Score =  192 bits (489), Expect = 2e-48
 Identities = 323/1397 (23%), Positives = 511/1397 (36%), Gaps = 198/1397 (14%)

Query: 547   RLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERR 606
             R +    L I +    D GTYT    +  G+  R+ H+ V   P  P +   T   ++  
Sbjct: 15455 RSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVT--DIKAE 15512

Query: 607   AINLTWTKPFD-GNSPLIRYILEM---SENNAPWTVLLASVDPKATSVTVKGLVPARSYQ 662
             +  LTW  P D G S +  Y+++    S   A W  +  +   K   +    L+P   Y+
Sbjct: 15513 SCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWK--LIPNGQYE 15570

Query: 663   FRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI 722
             FR+ AVN  G     K  + V         PP       RT  S+++ W PP ++  + I
Sbjct: 15571 FRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPI 15630

Query: 723   LKGYIIRYCLAGLPVGYQFKNITDADVNNLLLED-------LIIWTNYEIEVAAYNSAGL 775
               GY +     G P    +  ++ A +  + L+        L+    Y+    A N+AG+
Sbjct: 15631 -TGYWLEKREEGSP---YWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGI 15686

Query: 776   GVYSSKVTEWTLQGVPTVPPGNVHAEATNSTT---IRFTWNAPSPQFINGINQGYKLIAW 832
             G   S+ ++  + G P  PPG          T   I   W  P+       + G  +  +
Sbjct: 15687 GP-PSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAK------DGGSPIKGY 15739

Query: 833   EPEQEEEVTMVTARPNFQDSIHVG---FVSGLKKFTEYFTSVLCFTTPGDGPRS--TPQL 887
               E +EE T    R N  D +       V  LK+  +Y   V      G+   S  T ++
Sbjct: 15740 IVEMQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEI 15799

Query: 888   VRTH-EDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYL 946
               T  ++ P     +   + L        + P    G  T  + SWE   +    +   +
Sbjct: 15800 PATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTP-KSSWEFDGKAKKAMKDGV 15858

Query: 947   PNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA------STISSGVP-PELPGPPTNL 999
              ++  + ++      +   I     +  G+  ++A       T +  V   ++PGPP +L
Sbjct: 15859 HDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDL 15918

Query: 1000  GISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARS--M 1056
              +S+I   S  L ++ P  DG   I  +++E +     +G+ W  ++     PD  S   
Sbjct: 15919 KVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKR---TIDGKAWTKVN-----PDCGSTTF 15970

Query: 1057  EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQA--PPDMAPANVSLRTASETSLW 1114
              VPDL     Y FR+R  N  G  PP +  ++        PPD  P  + +   ++ ++ 
Sbjct: 15971 VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPD-PPIKLKIGLITKNTVH 16029

Query: 1115  LRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQ----DRVERDYTIEDLEEWTE 1170
             L W P    + +G      Y ++    D  G       Q    D  E  +T+EDL E  E
Sbjct: 16030 LSWKP---PKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGE 16086

Query: 1171  YRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNG 1230
             Y  +V+A NA G    S TV           GP +        S  L  + EV E     
Sbjct: 16087 YEFRVKAVNAAGVSKPSATV-----------GPCDCQRPDMPPSIDLKEFMEVEEGTNVN 16135

Query: 1231  LV-----------LGYKVMYKEKDS------DTQPRFWLVEGNSSRSAQLTGLGKYVLYE 1273
             +V             +K   K+ D+      DT     +V+   +     +      LY 
Sbjct: 16136 IVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY- 16194

Query: 1274  VQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIIL 1332
               + A   +G  S      +   +   PGPP+G I F  V    + L W PP    G  +
Sbjct: 16195 -TITAVNNLGTASKE----MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKI 16249

Query: 1333  AYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392
                +  +          V    P    YT   L     Y+FRI AQ + G GE  ++   
Sbjct: 16250 TNYVIEKREANRKTWVHVS-SEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPE 16308

Query: 1393  TTEKR-DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALH 1450
             T       P  P +P V    V   S+ ++W EP  DG SPV  Y ++ ++  S RW   
Sbjct: 16309 TARNLFSVPGAPDKPTV--SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRV 16366

Query: 1451  SASVSHNAS---SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI 1507
             +       +   S+ V  L   + Y+FRV A N  G    S  S+  T         P  
Sbjct: 16367 NRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 16426

Query: 1508  LSVTPHTTTSVLIRWQPPAED---KINGILLGFR--------------IRYRELLYEGL- 1549
               VT  T +S  + W PP +D   K+ G ++ ++              +R  +L+  GL 
Sbjct: 16427 PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLK 16486

Query: 1550  ---------RGFTLRGINNPGATWAELTSMYSMRN-LSRP--SLTQYELDNLNKHRRYEI 1597
                      R   + GI  PG    E+T +  M++ L  P   L     D +  H    I
Sbjct: 16487 EGAFYKFRVRAVNIAGIGEPG----EVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVI 16542

Query: 1598  RMSVYNAVGEGPS--------SPPQEVFV------------------------------G 1619
             R+  Y +    P+        + PQE  +                              G
Sbjct: 16543 RIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG 16602

Query: 1620  EA----------VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRG 1669
             E           VP       + H  T     +TW  P  D     I  Y I   E+ R 
Sbjct: 16603 ERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPE-DDGGSPITNYVIEKRESDRR 16661

Query: 1670  NLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQG---QTQQAAPSA 1726
               T    T  +   +  ++ L    AY   +AA N+ G GP    ++    +     P  
Sbjct: 16662 AWTP--VTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPER 16719

Query: 1727  PSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWL 1786
             P  ++  E+T  +V ++W  P++  G  E    V E  S + G  K   V          
Sbjct: 16720 PEDLEVKEVTKNTVTLTWNPPKYDGG-SEIINYVLE--SRLIGTEKFHKVTNDNLLSRKY 16776

Query: 1787  KVKDLAEGVTYRFRIRA 1803
              VK L EG TY +R+ A
Sbjct: 16777 TVKGLKEGDTYEYRVSA 16793



 Score =  190 bits (483), Expect = 1e-47
 Identities = 365/1536 (23%), Positives = 598/1536 (38%), Gaps = 180/1536 (11%)

Query: 448   QLPRFTPLESGSLLISPTHISDAGT-------YTCLATNSRGV--DEASADLVVWARTRI 498
             +LP    +++    I  TH    G        +  +A N+ GV  + + +   + AR  +
Sbjct: 22479 ELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEV 22538

Query: 499   TKPP-------QDQSVIKGTQASMV-CGVTHDPRVTIRYIWEKDGATLGTESHPRIR-LD 549
               P        +D  V+   ++  V   +   P  TI+  W K    L   +   I+  D
Sbjct: 22539 DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQ--WIKGDQELSNTARLEIKSTD 22596

Query: 550   RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAIN 609
                SL +      D G Y  +  +  G  S + +++V   P  PE PV  +S V      
Sbjct: 22597 FATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVV-ISGVTAEKCT 22655

Query: 610   LTWTKPF-DGNSPLIRYILEMSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCA 667
             L W  P  DG S +I YI+E  E +   WTV+ A+V   +  VT   L+    Y FR+ A
Sbjct: 22656 LAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK--LLEGNEYTFRIMA 22713

Query: 668   VNDVGKGQFSKDTERVSL-PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGY 726
             VN  G G+  +    V+  P   P AP    + +  T  S+++ W+ P     + IL GY
Sbjct: 22714 VNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTV-TKDSMIVVWERPASDGGSEIL-GY 22771

Query: 727   IIRYCLAGLPVGYQFKNITDADVNNLLLE--DLIIWTNYEIEVAAYNSAGLGVYS--SKV 782
             ++         G ++       +  L L    LI   +YE  V+A N+AGL   S  S  
Sbjct: 22772 VLE---KRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAY 22828

Query: 783   TEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGIN-QGYKLIAWEPEQEEEVT 841
              +         PP N        +++  +W+ P   +  G   QGY ++        E T
Sbjct: 22829 QKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPI--YDGGCEIQGY-IVEKCDVSVGEWT 22885

Query: 842   MVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPV--- 898
             M T  P   +  ++     L+K  EY   +      G G          H DVPGP+   
Sbjct: 22886 MCTP-PTGINKTNIEVEKLLEKH-EYNFRICAINKAGVGE---------HADVPGPIIVE 22934

Query: 899   GHLSFSEI-LDTSLK--VSWQEPGEKNGI--LTGYRISWEEYNRTNTRVTHY-LPNVTLE 952
               L   +I LD  L+  ++ +  G       + G      ++ + +  +    + +VT  
Sbjct: 22935 EKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSS 22994

Query: 953   YRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQ 1012
             +    L  +  Y      +T +      ++ ++  V  + P PP NL ++ I   SV++ 
Sbjct: 22995 FTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVL-DTPSPPVNLKVTEITKDSVSIT 23053

Query: 1013  FRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRM 1071
             + P   DG + I  ++VE +     E         ++N     S ++  L     Y FR+
Sbjct: 23054 WEPPLLDGGSKIKNYIVEKR-----EATRKSYAAVVTN-CHKNSWKIDQLQEGCSYYFRV 23107

Query: 1072  RQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPES 1131
                N  G   P+Q +  I+  + P    P  +++   +  S+ L W    + E++G  + 
Sbjct: 23108 TAENEYGIGLPAQTADPIKVAEVP--QPPGKITVDDVTRNSVSLSWT---KPEHDGGSKI 23162

Query: 1132  VGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTV 1190
             + Y ++      H +  S   + +      I +L +  EY  +V A N  G S P S  V
Sbjct: 23163 IQYIVEMQAK--HSEKWSECARVK-SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAV 23219

Query: 1191  VGRTRESV--PSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQP 1248
                 ++ V  P   P   S        + +   EVP + R    + +         D  P
Sbjct: 23220 PIVAKDLVIEPDVKPAFSSYSVQVGQDLKI---EVPISGRPKPTITWT-------KDGLP 23269

Query: 1249  RFWLVEGNSSRSAQLTGL----------GKYVLYEVQVLAFTRIGDGSPSHPPILERTLD 1298
                    N + S  LT L          G+Y +    V     +G  + S    +E    
Sbjct: 23270 LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANV-----VGQKTAS----IEIVTL 23320

Query: 1299  DVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSA 1357
             D P PP G + F +V   S+ L W PP    G  +   I  + +TTT  T    V A  A
Sbjct: 23321 DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTT--TVWDVVSATVA 23378

Query: 1358  R-QYTATGLKPESVYLFRITAQTRKGWGEAAEA-LVVTTEKRDRPQPPSRPMVQQEDVRA 1415
             R     T LK  + Y FRI A+ R G   A E+  +V       P PP  P      +  
Sbjct: 23379 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATA--ISK 23436

Query: 1416  RSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKF 1474
              S+++ W EP ++G SPV  Y ++ +E  S  W   + ++ H+ + F    L+    Y+F
Sbjct: 23437 DSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHD-TQFKAQNLEEGIEYEF 23495

Query: 1475  RVKATNDIGDSEFSEESESLTTLQAA-PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGI 1533
             RV A N +G  + S+ SE         P   P  + V  +  T   ++W  P  D    +
Sbjct: 23496 RVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEIT---LQWTKPVYDG-GSM 23551

Query: 1534  LLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHR 1593
             + G+ +  R+L               P   W +     S  N+     TQ+ +  L + +
Sbjct: 23552 ITGYIVEKRDL---------------PDGRWMKA----SFTNVIE---TQFTVSGLTEDQ 23589

Query: 1594  RYEIRMSVYNAVG--------EGPSSPPQEVFVGEAVPTAAPRNVVVHGATAT---QLDV 1642
             RYE R+   NA G         GP +   EV +         R+ +V  A  T   + DV
Sbjct: 23590 RYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADV 23649

Query: 1643  TWEP-PPLDSQNGDIQGYKIYFWEAQRGNLTER-VKTLFLAENSVKLKNLTGYTAYMVSV 1700
               +P P ++   GD +       E+ R  +     K L + ++++++            +
Sbjct: 23650 HGKPLPTIEWLRGDKE-----IEESARCEIKNTDFKALLIVKDAIRI------DGGQYIL 23698

Query: 1701  AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLV 1760
              A N AG   +S P   +           V+ + +T+   +++W +P   +G  +    V
Sbjct: 23699 RASNVAGS--KSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTW-SPPLQDGGSDISHYV 23755

Query: 1761  YEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA-KTFTYGPEIE-ANVTT 1818
              E          +V  +V  NS   LKV  L EG  Y FRI A   +  G  +E A V  
Sbjct: 23756 VEKRETSRLAWTVVASEVVTNS---LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 23812

Query: 1819  GPGEGAPGPP-GVPIIVRYSSAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDI 1876
                   PGPP  + +      ++ + W+  D  G   I  Y++E R      W   IK  
Sbjct: 23813 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRW---IKCN 23869

Query: 1877  PKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPS 1912
              + ++     +  L     Y+FRV A N  G G PS
Sbjct: 23870 KRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPS 23905



 Score =  190 bits (482), Expect = 1e-47
 Identities = 360/1569 (22%), Positives = 576/1569 (36%), Gaps = 242/1569 (15%)

Query: 412   TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
             TV  G  + L    +G P P ITW K + IL           P +S ++ I  +  SD G
Sbjct: 13701 TVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKS-TVTIVDSKRSDTG 13759

Query: 472   TYTCLATNSRGVDEASADLVVWAR---------TRITK--------PPQDQSVIKGTQAS 514
             TY   A N  G   A  ++ V  +         T +T         PP+D         S
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDG------GS 13813

Query: 515   MVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA 574
              +     + R T   +W K  +T+   +    +L  N               Y  RV + 
Sbjct: 13814 KITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKE-------------YIFRVAAE 13860

Query: 575   ---GGNDSRSAHLRVRQLPHAPEHPVATL--STVERRAINLTWTKPFD-GNSPLIRYILE 628
                G  +   A     +    P  P   L  S + + A+ LTW +P D G SP+  Y +E
Sbjct: 13861 NMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVE 13920

Query: 629   MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL--P 686
               + +    V    +  K T+  VKGL   + Y+FR+ A N  G G+ SK TE + +  P
Sbjct: 13921 RLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDP 13980

Query: 687   EEPPTAPPQNVIAS-GRTNQSIMIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNI 744
              +PP  P +  +   G+T  S+ + W  P   H  G  ++ Y+I     G     +    
Sbjct: 13981 IDPPWPPGKPTVKDVGKT--SVRLNWTKP--EHDGGAKIESYVIEMLKTGTDEWVRVAE- 14035

Query: 745   TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGNVHAEA 802
                     LL  L+    Y   V A N AG    S  S       +  P  PP  +    
Sbjct: 14036 -GVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVIN 14094

Query: 803   TNSTTIRFTWNAPSPQFINGI------NQGYKLIAWEP-EQEEEVTMVTARPNFQDSIHV 855
                 T    W  P     + I       +  +   W+  +   + T  T  P  + S++V
Sbjct: 14095 ITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYV 14154

Query: 856   GFVS-----GLKKFTEYFTSVLC---FTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEIL 907
               V+     G   +TE   SVL    FTT                  PGP   L+  ++ 
Sbjct: 14155 FRVAAENAIGQSDYTEIEDSVLAKDTFTT------------------PGPPYALAVVDVT 14196

Query: 908   DTSLKVSWQEPGEKNG-ILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTI 966
                + + W+ P    G  +  Y I  +E   T              +RVT +   T    
Sbjct: 14197 KRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQF 14256

Query: 967   EVAAMTSKGQGQVSAST--ISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSI 1023
             +V A    G G  S  T  +S   P   P PP +L +++ G + + + ++ P  +G + I
Sbjct: 14257 QVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPI 14316

Query: 1024  SRWLVE-AQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPP 1082
               + VE   VG     E+W+ ++    + D +      + P   Y  R+R VN +G S P
Sbjct: 14317 IGYHVEMCPVGT----EKWMRVNSRPIK-DLKFKVEEGVVPDKEYVLRVRAVNAIGVSEP 14371

Query: 1083  SQPSRKIQTLQAPPDMAPANVSLRTAS---------ETSLWLRWMPLPEMEYNGNPESVG 1133
             S+ S  +  +   PD  P  + L T              +  R +P+P + ++ + + V 
Sbjct: 14372 SEISENV--VAKDPDCKP-TIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVK 14428

Query: 1134  YKIKYSRSDGHGKTLSHV-VQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVG 1192
                + +  + H    +H+ V   V  D  I        Y + ++  N +GS   S  V  
Sbjct: 14429 ASDRLTMKNDH--ISAHLEVPKSVRADAGI--------YTITLE--NKLGSATASINV-- 14474

Query: 1193  RTRESVPSSGP-TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW 1251
                + +   GP  ++ A   T SS  + W E PE D    +L Y  + + +++  +    
Sbjct: 14475 ---KVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPILHY--VLERREAGRRTYIP 14528

Query: 1252  LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS--PSHPPILERTLDDVPGPPMGILF 1309
             ++ G +  S  +  L     Y  +V A  ++G G       P++ +     P PP+ +  
Sbjct: 14529 VMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEV 14588

Query: 1310  PEVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPE 1368
                   ++ + W+PP    G  I+ Y I              E L P    YTA GL+  
Sbjct: 14589 HNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP-ILTYTAKGLEEG 14647

Query: 1369  SVYLFRITAQTRKGWGEAAEALVVT--TEKRDRPQPPSRPM--VQQEDVRARSVLLS--- 1421
               Y FR+ A+   G  E + A   T   +  D P+   R    V++ D  A    +S   
Sbjct: 14648 KEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSP 14707

Query: 1422  -----WEPGSDGLSPV------------RYYTIQTRE---LPSGRWALHSASVSHNASSF 1461
                  W    + + P             R   +Q  E   LP  +      S    +   
Sbjct: 14708 YPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLR 14767

Query: 1462  IVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPH-TTTSVLI 1520
             + D L+P     + +K  ND G       +++  T+       P I  V      TSVL 
Sbjct: 14768 VRDSLRPDHGL-YMIKVENDHG------IAKAPCTVSVLDTPGPPINFVFEDIRKTSVLC 14820

Query: 1521  RWQPPAEDKINGILLGFRIRYRELLYEGLRGFTL--RGINNPGATWAELTSMYSMRNLSR 1578
             +W+PP +D  + I+                 +TL  +    P + W  +TS  ++R+   
Sbjct: 14821 KWEPPLDDGGSEII----------------NYTLEKKDKTKPDSEWIVVTS--TLRH--- 14859

Query: 1579  PSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV-PTAAPRNVVVHGATA 1637
                 +Y +  L + + Y  R+   N  G GP    + +   +   P  AP   +V   T+
Sbjct: 14860 ---CKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTS 14916

Query: 1638  TQLDVTWEPPPLDSQNGD-IQGYKIYFWEAQRGNLT--ERVKTLFLAENSVKLKNLTGYT 1694
               + V W  P     NG  I G   Y+ E +  N T   RV    L      +  L    
Sbjct: 14917 NSMLVKWNEP---KDNGSPILG---YWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGL 14970

Query: 1695  AYMVSVAAFNAAGDGPRSTPTQGQT--QQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
              Y+  V A NAAG G  S P+  +T     +P  P   + ++ ++T++ + WE P F  G
Sbjct: 14971 TYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGG 15030

Query: 1753  ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEI 1812
                G  + Y     + G ++      K        VK++ EG  Y+ R+ A         
Sbjct: 15031 ---GEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSA--------- 15078

Query: 1813  EANVTTGPGEGAPG------------PPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE 1860
                     GEG PG            PP V + V     I I       GK      V+ 
Sbjct: 15079 ----VNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIM-----AGKTLRIPAVVT 15129

Query: 1861  ARPSDEGLW 1869
              RP    +W
Sbjct: 15130 GRPVPTKVW 15138



 Score =  189 bits (481), Expect = 2e-47
 Identities = 331/1484 (22%), Positives = 562/1484 (37%), Gaps = 198/1484 (13%)

Query: 416   GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG--SLLISPTHISDAGTY 473
             G S+ L     G P P + W K       G ++      + S   SL++   +  D+G Y
Sbjct: 22957 GGSLRLFVPIKGRPTPEVKWGK-----VDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKY 23011

Query: 474   TCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI------ 527
             T    NS G   A   + V        PP +  V + T+ S+   +T +P +        
Sbjct: 23012 TLTLENSSGTKSAFVTVRV---LDTPSPPVNLKVTEITKDSV--SITWEPPLLDGGSKIK 23066

Query: 528   RYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG----GNDSRSAH 583
              YI EK  AT  + +       +N S  I Q   G   +Y  RV +      G  +++A 
Sbjct: 23067 NYIVEKREATRKSYAAVVTNCHKN-SWKIDQLQEGC--SYYFRVTAENEYGIGLPAQTAD 23123

Query: 584   -LRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLA 641
              ++V ++P  P     T+  V R +++L+WTKP  DG S +I+YI+EM   ++      A
Sbjct: 23124 PIKVAEVPQPPGK--ITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECA 23181

Query: 642   SVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ--------FSKDTERVSLPEEPPTAP 693
              V  K+    +  L     Y FR+ AVN+ G+           +KD   V  P+  P   
Sbjct: 23182 RV--KSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDL--VIEPDVKPAFS 23237

Query: 694   PQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFK-NITDADVNNL 752
               +V         + I  +P P            I +   GLP+    + N+TD+    L
Sbjct: 23238 SYSVQVGQDLKIEVPISGRPKPT-----------ITWTKDGLPLKQTTRINVTDS----L 23282

Query: 753   LLEDLIIWTNYEIEVAAYNSAGLGVYSSKVT--EWTLQGVPTVPPGNVHAEATNSTTIRF 810
              L  L I   ++ +   Y      V   K    E      P  P G V  +  ++ +I  
Sbjct: 23283 DLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITL 23342

Query: 811   TWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTS 870
             +WN P          G ++  +  ++ +  T V    +   +     V+ LK  TEY   
Sbjct: 23343 SWNPPL------YTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFR 23396

Query: 871   VLCFTTPGDG--PRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTG 927
             +      G      S P + +     PGP G    + I   S+ + W EP    G  + G
Sbjct: 23397 IFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIG 23456

Query: 928   YRISWEEYN-----RTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAS 982
             Y +  +E N     + N  + H       +++   L     Y   V A    G G+ S +
Sbjct: 23457 YHLERKERNSILWTKVNKTIIH-----DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKN 23511

Query: 983   T--ISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGE 1039
             +    +  P + PG P  + +       +TLQ+ +P YDG + I+ ++VE +    G   
Sbjct: 23512 SECYVARDPCDPPGTPEPIMVKR---NEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWM 23568

Query: 1040  EWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA 1099
             +    + +  +       V  L     Y FR+   N  G    S+PS     + A  ++ 
Sbjct: 23569 KASFTNVIETQ-----FTVSGLTEDQRYEFRVIAKNAAGAI--SKPSDSTGPITAKDEVE 23621

Query: 1100  PANVSLR---------TASET---SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKT 1147
                +S+           A ET      +   PLP +E+    + +    +    +   K 
Sbjct: 23622 LPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKA 23681

Query: 1148  LSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVS 1207
             L  +V+D +  D            +  ++A N  GS  +   V    R   P  GP  V+
Sbjct: 23682 LL-IVKDAIRIDGG----------QYILRASNVAGSKSFPVNVKVLDRPG-PPEGPVQVT 23729

Query: 1208  ALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNS--SRSAQLTG 1265
              +  TS    + WS  P     G  + + V+ K    +T    W V  +   + S ++T 
Sbjct: 23730 GV--TSEKCSLTWS--PPLQDGGSDISHYVVEKR---ETSRLAWTVVASEVVTNSLKVTK 23782

Query: 1266  LGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPP 1324
             L +   Y  +++A  + G G P    P+L +    +PGPP  +    +   S+ + W  P
Sbjct: 23783 LLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRP 23842

Query: 1325  AAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG 1384
              +  G  +   I  + + +            +  +   TGL  +  Y FR++A+   G G
Sbjct: 23843 DSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVG 23902

Query: 1385  EAAEALVV--TTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRE 1441
             E + A V     +   +P PP+   +   D    S+ L+W +P  DG S +  Y ++  +
Sbjct: 23903 EPSPATVYYKACDPVFKPGPPTNAHIV--DTTKNSITLAWGKPIYDGGSEILGYVVEICK 23960

Query: 1442  LPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501
                  W + +       + F + +L     YK RV A N +G  E +  S   T      
Sbjct: 23961 ADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEAT--SVPGTVKPEDK 24018

Query: 1502  DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
              EAP  L +       +++R    A   I                        +G   P 
Sbjct: 24019 LEAPE-LDLDSELRKGIVVRAGGSARIHI----------------------PFKGRPTPE 24055

Query: 1562  ATWAELTSMYS--MRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVG 1619
              TW+     ++  ++     + TQ  +DN +++   +  + + N+ G    S    V V 
Sbjct: 24056 ITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG----SKSAFVTVK 24111

Query: 1620  EAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR---GNLTERVK 1676
                    P+N+ V         + WEPP +D     ++ Y I   E+ R    N++ +  
Sbjct: 24112 VLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDG-GAKVKNYVIDKRESTRKAYANVSSK-- 24168

Query: 1677  TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELT 1736
                 ++ S K++NLT    Y   V A N  G G              PS P  V  ++++
Sbjct: 24169 ---CSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVS 24225

Query: 1737  TTSVNVSWEAPQFPNGI-LEGYRLVYEPCS----PVDGVSKIVTVDVKGNSPLWLKVKDL 1791
              TS ++ WE P+   G  + GY +  +P       +   SK+    V G          L
Sbjct: 24226 QTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTG----------L 24275

Query: 1792  AEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
             + G  Y+FR++A    Y  +         G+  P   GVP+I +
Sbjct: 24276 SSGQEYQFRVKA----YNEK---------GKSDPRVLGVPVIAK 24306



 Score =  189 bits (479), Expect = 3e-47
 Identities = 429/1885 (22%), Positives = 716/1885 (37%), Gaps = 273/1885 (14%)

Query: 124   VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENT---LVILSTVAPDAGR 180
             V  GE   I  P   + P P V+W +DG+++  S R+ +  ++    L +  +V  DAG 
Sbjct: 14398 VIEGEKLSIPVP-FRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGI 14456

Query: 181   YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVAN 240
             Y +   N K G    S  I + V  + GP   I        K + +   + ++T E    
Sbjct: 14457 YTITLEN-KLGSATAS--INVKVIGLPGPCKDI--------KASDITKSSCKLTWEPPEF 14505

Query: 241   ARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVL-------RSSSV 293
                   LH + ++          +  RR  IP  +G +   +  + ++       R  +V
Sbjct: 14506 DGGTPILHYVLER---------REAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAV 14556

Query: 294   PSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW----YKDAAVV 349
               V  G Y+  L+ P   ++P++      +  VD+          +ITW    Y   + +
Sbjct: 14557 NKVGGGEYIE-LKNPVIAQDPKQ----PPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKI 14611

Query: 350   E---VEKLTRFRQR----NDGGLQI-----SGLVPDDTGMFQCFARNAAGEVQTSTYLAV 397
                 +EK+ +  +R    N+  + I      GL       F+  A NAAG  + S     
Sbjct: 14612 MGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPP 14671

Query: 398   TSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLES 457
             T     I          D   V+L        R ++  ++G+ I    S+         S
Sbjct: 14672 TKAVDPI----------DAPKVIL--------RTSLEVKRGDEIALDASI---------S 14704

Query: 458   GSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVC 517
             GS   + T I D             + + +A LV   +  + +  ++  V+  TQ     
Sbjct: 14705 GSPYPTITWIKDENVIV-----PEEIKKRAAPLVRRRKGEVQE--EEPFVLPLTQ----- 14752

Query: 518   GVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGN 577
                   R++I      D +  G ES  R+R           +   D G Y  +V +  G 
Sbjct: 14753 ------RLSI------DNSKKG-ESQLRVR----------DSLRPDHGLYMIKVENDHGI 14789

Query: 578   DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAP- 635
                   + V   P  P + V     + + ++   W  P D G S +I Y LE  +   P 
Sbjct: 14790 AKAPCTVSVLDTPGPPINFV--FEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPD 14847

Query: 636   --WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL-PEEPPTA 692
               W V+ +++     SVT   L+  + Y FR+ A N  G G        V+  P  PP A
Sbjct: 14848 SEWIVVTSTLRHCKYSVTK--LIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDA 14905

Query: 693   PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNL 752
             P + ++    +N S++++W  P +   NG     I+ Y L    V     +  +  + N 
Sbjct: 14906 PDKPIVEDVTSN-SMLVKWNEPKD---NG---SPILGYWLEKREVNSTHWSRVNKSLLNA 14958

Query: 753   L---LEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNV--HAEATNSTT 807
             L   ++ L+    Y   V A N+AG G +S      T    P  PPG        T+STT
Sbjct: 14959 LKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHD-PISPPGPPIPRVTDTSSTT 15017

Query: 808   IRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTAR-PNFQDSIHVGFVSGLKKFTE 866
             I   W  P+       N G +++ +  +++   T   +R       +    V  +++  +
Sbjct: 15018 IELEWEPPA------FNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGAD 15071

Query: 867   YFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKN---- 922
             Y   V      G+GP    Q V   E    P   L      D S+K   Q    K     
Sbjct: 15072 YKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVEL------DVSVKGGIQIMAGKTLRIP 15125

Query: 923   GILTGYRIS---W--EEYNRTNTRVTHYLPNVTLEYRVTGLTALTT-YTIEVAAMTSKGQ 976
              ++TG  +    W  EE      RV   + NV  +  +    AL   +   V   T+   
Sbjct: 15126 AVVTGRPVPTKVWTKEEGELDKDRVV--IDNVGTKSELIIKDALRKDHGRYVITATNSCG 15183

Query: 977   GQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVV 1035
              + +A+ +      ++PGP  +L       +   L +  P  DG + I+ +++E +   +
Sbjct: 15184 SKFAAARVEVF---DVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKM 15240

Query: 1036  GEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAP 1095
                 + +       E +    ++  L     Y FR+   N  G  PP +    +      
Sbjct: 15241 HTWRQPI-------ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLG 15293

Query: 1096  PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDR 1155
             P  +P  ++    +++++ L W    E   NG     GY I+  R   H K     V  R
Sbjct: 15294 PPTSPERLTYTERTKSTITLDWK---EPRSNGGSPIQGYIIEKRR---HDKPDFERVNKR 15347

Query: 1156  V--ERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESVPSSGPTNVSALATT 1212
             +     + +E+L+E   Y  +V+A N IG S P     V    + VP   PT    L+  
Sbjct: 15348 LCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVP---PTIKLRLSVR 15404

Query: 1213  SSSMLVRWSE---VPEADRNGLVLGYKVMYKEKDSDTQPR--FWLVEGNSSRSAQLTGLG 1267
               ++ V+  E   +P AD  GL +      K +    +P     + +   SRS   T L 
Sbjct: 15405 GDTIKVKAGEPVHIP-ADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELS 15463

Query: 1268  --KYVLYE---VQVLAFTRIGDGSPS-HPPILERTLDDVPGPPMGILFPEVRTTSVRLIW 1321
               K V  +     V A  R+G    + H  + +R     P PP  +   +++  S  L W
Sbjct: 15464 IPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDR-----PSPPRNLAVTDIKAESCYLTW 15518

Query: 1322  QPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSA-RQYTATGLKPESVYLFRITAQTR 1380
               P    G  + + +  + + +       EV   +  ++Y    L P   Y FR+ A  +
Sbjct: 15519 DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNK 15578

Query: 1381  KGWGEAAEA-LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSD-GLSPVRYYTIQ 1438
              G  +  ++  VV  +    P PP +P V        S+L+SW P  D G SP+  Y ++
Sbjct: 15579 YGISDECKSDKVVIQDPYRLPGPPGKPKVLART--KGSMLVSWTPPLDNGGSPITGYWLE 15636

Query: 1439  TRELPSGRWALHSAS----VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESE-S 1493
              RE  S  W+  S +    V      F V RL     Y+FR  A N  G    SE S+  
Sbjct: 15637 KREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPE 15696

Query: 1494  LTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFT 1553
             +      P   P+   V   T +S+ + W+PPA+D  + I  G+ +  +E   EG   + 
Sbjct: 15697 VAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIK-GYIVEMQE---EGTTDW- 15751

Query: 1554  LRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSP 1612
              + +N P         +               + NL + R+Y  R+   N  GE  PS  
Sbjct: 15752 -KRVNEPDKLITTCECV---------------VPNLKELRKYRFRVKAVNEAGESEPSDT 15795

Query: 1613  PQEVFVGEA-------VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWE 1665
               E+   +        +   A   +V    +  ++    +  P    + +  G      +
Sbjct: 15796 TGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMK 15855

Query: 1666  AQRGNLTERVKTLFLAENSVKL------KNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQT 1719
                 ++ E  + L  AENS  +      ++ TG      S+ A N AG   + T      
Sbjct: 15856 DGVHDIPEDAQ-LETAENSSVIIIPECKRSHTG----KYSITAKNKAG---QKTANCRVK 15907

Query: 1720  QQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDV 1778
                 P  P  +K S++T  S  +SW+ P    G  ++GY +       +DG +       
Sbjct: 15908 VMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRT---IDGKAWTKVNPD 15964

Query: 1779  KGNSPLWLKVKDLAEGVTYRFRIRAKT-FTYGPEIEA-NVTTGPGEGAPGPPGVPIIVRY 1836
              G++     V DL     Y FR+RA+  F  GP +E    TT      P  P + + +  
Sbjct: 15965 CGSTTF--VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGL 16022

Query: 1837  SSAIAIHWSSGDP---GKGPITRYVIEARPSD-----EGLWDILIKDIPKEVSSYTFSMD 1888
              +   +H S   P   G  P+T Y++E    D     +  W    K   ++V    F+++
Sbjct: 16023 ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNK---RDVEELQFTVE 16079

Query: 1889  ILKPGVSYDFRVIAVNDYGFGTPSS 1913
              L  G  Y+FRV AVN  G   PS+
Sbjct: 16080 DLVEGGEYEFRVKAVNAAGVSKPSA 16104



 Score =  187 bits (474), Expect = 1e-46
 Identities = 315/1447 (21%), Positives = 553/1447 (38%), Gaps = 151/1447 (10%)

Query: 524   RVTIRYIWEKDGATLGTESHPRIRLDRNGSL-HISQTWSGDIGTYTCRVISAGGNDSRSA 582
             R T    W KD   L   +        N SL  I      D+G Y  ++ ++ G    + 
Sbjct: 22174 RPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETL 22233

Query: 583   HLRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP-WTVLL 640
             ++ V   P  P  PV  +  V   +I L+W  P +DG S +  YI+E  + +   W ++ 
Sbjct: 22234 NVIVLDKPGPPTGPVK-MDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVS 22292

Query: 641   ASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIAS 700
             A+V    T++    L     YQFR+ A N  GK  +      V+        PP   + +
Sbjct: 22293 ATV--ARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVT 22350

Query: 701   GRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIW 760
               +  S+ +QW  P     + ++  ++ R       + +   N T           L   
Sbjct: 22351 LSSRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEG 22408

Query: 761   TNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFI 820
               YE  V+A N  G+G   SKV+E  +   P  PPG   A      ++   W  P+    
Sbjct: 22409 VEYEFRVSAENIVGIGK-PSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPT---- 22463

Query: 821   NGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPG- 878
                + G K+  +  E++E       + +F + I   F V+GL +   Y   V+     G 
Sbjct: 22464 --YDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGV 22521

Query: 879   -DGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNR 937
                P  +   +   ++V  P   +S       ++ V   E  + +  + G  I   ++ +
Sbjct: 22522 FSEPSESTGAITARDEVDPP--RISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIK 22579

Query: 938   TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL----- 992
              +  +++     T    +      T+ +++ A     G   + A  ++      +     
Sbjct: 22580 GDQELSN-----TARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVL 22634

Query: 993   --PGPPTN-LGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQLS 1048
               PGPP   + IS +     TL ++P   DG + I  ++VE +          L+   + 
Sbjct: 22635 DRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRE------TSRLVWTVVD 22688

Query: 1049  NEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTA 1108
                   S +V  L     Y+FR+  VN  G   P +    +         AP    + T 
Sbjct: 22689 ANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTV 22748

Query: 1109  SETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV--ERDYTIEDLE 1166
             ++ S+ + W        +G  E +GY ++    +G   T  H    R+  E    +  L 
Sbjct: 22749 TKDSMIVVW---ERPASDGGSEILGYVLEKRDKEGIRWTRCH---KRLIGELRLRVTGLI 22802

Query: 1167  EWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESVPSSGP-TNVSALATTSSSMLVRWSEVP 1224
             E  +Y  +V A NA G S P   +   +  + +   GP  N   +  T SS+ + WS+ P
Sbjct: 22803 ENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSK-P 22861

Query: 1225  EADRNGLVLGYKVMYKEKDSDTQPRFWLV----EGNSSRSAQLTGLGKYVLYEVQVLAFT 1280
               D    + GY V    +  D     W +     G +  + ++  L +   Y  ++ A  
Sbjct: 22862 IYDGGCEIQGYIV----EKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAIN 22917

Query: 1281  RIGDGSPSHPP---ILERTLDDVPGPPMGILFPEVRTT----SVRLIWQPPAAPNGIILA 1333
             + G G  +  P   I+E  L+  P   + +   ++       S+RL       P   +  
Sbjct: 22918 KAGVGEHADVPGPIIVEEKLE-APDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW 22976

Query: 1334  YQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVY---LFRITAQTRKGWGEAAEAL 1390
              ++   +     + A ++V +     +T+  L   + Y    + +T +   G     ++ 
Sbjct: 22977 GKVDGEIR----DAAIIDVTS----SFTSLVLDNVNRYDSGKYTLTLENSSG----TKSA 23024

Query: 1391  VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSGRWAL 1449
              VT    D P PP    V +  +   SV ++WEP   DG S ++ Y ++ RE     +A 
Sbjct: 23025 FVTVRVLDTPSPPVNLKVTE--ITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAA 23082

Query: 1450  HSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILS 1509
                +   N  S+ +D+L+   SY FRV A N+ G    ++ ++ +   +    + P  ++
Sbjct: 23083 VVTNCHKN--SWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVP--QPPGKIT 23138

Query: 1510  VTPHTTTSVLIRWQPPAED---KINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAE 1566
             V   T  SV + W  P  D   KI   ++  + ++ E                    W+E
Sbjct: 23139 VDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSE-------------------KWSE 23179

Query: 1567  LTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-------PSSPPQEVFVG 1619
                + S+         Q  + NL +   Y  R+   N  G         P      V   
Sbjct: 23180 CARVKSL---------QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEP 23230

Query: 1620  EAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLF 1679
             +  P  +  +V V      ++ ++  P P  +   D    K    +  R N+T+   +L 
Sbjct: 23231 DVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLK----QTTRINVTD---SLD 23283

Query: 1680  LAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTS 1739
             L   S+K  +      Y ++VA  N  G    S       +   P  P  VKF +++  S
Sbjct: 23284 LTTLSIKETHKDDGGQYGITVA--NVVGQKTASIEIVTLDKPDPPKGP--VKFDDVSAES 23339

Query: 1740  VNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 1799
             + +SW  P +  G  +    + +       V  +V+  V   +   LKV  L  G  Y+F
Sbjct: 23340 ITLSWNPPLYTGGC-QITNYIVQKRDTTTTVWDVVSATVARTT---LKVTKLKTGTEYQF 23395

Query: 1800  RIRAKTF---TYGPEIEANVTTGPGEGAPGPPGVPIIVRYSS-AIAIHWSSG-DPGKGPI 1854
             RI A+     ++  E +  V   P +  PGPPG P     S  ++ I W    + G  P+
Sbjct: 23396 RIFAENRYGQSFALESDPIVAQYPYK-EPGPPGTPFATAISKDSMVIQWHEPVNNGGSPV 23454

Query: 1855  TRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSP 1914
               Y +E +  +  LW  + K I   +    F    L+ G+ Y+FRV A N  G G  S  
Sbjct: 23455 IGYHLERKERNSILWTKVNKTI---IHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKN 23511

Query: 1915  SQSVPAQ 1921
             S+   A+
Sbjct: 23512 SECYVAR 23518



 Score =  177 bits (449), Expect = 1e-43
 Identities = 352/1605 (21%), Positives = 600/1605 (37%), Gaps = 162/1605 (10%)

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP-------LDSTVI--DGM 417
             +SGL  D    F+  A+NAAG +   +  +      +    P          TVI   G 
Sbjct: 21418 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 21477

Query: 418   SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
             +  L  + SG P P + W K  + L  G+ +L       S +L+   +   D+G YT  A
Sbjct: 21478 AFRLEADVSGRPPPTMEWSKDGKEL-EGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTA 21536

Query: 478   TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDP-------RVTIRYI 530
             TN  G  +   ++ V  R     PP+    +     S  C ++  P       ++    +
Sbjct: 21537 TNPGGFAKHIFNVKVLDRPG---PPEGPLAVTEV-TSEKCVLSWFPPLDDGGAKIDHYIV 21592

Query: 531   WEKDGATLG-TESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA---GGNDSRSAHLRV 586
              +++ + L  T     +++ +   L +++   G+   Y  RV++    G  +   +   +
Sbjct: 21593 QKRETSRLAWTNVASEVQVTK---LKVTKLLKGN--EYIFRVMAVNKYGVGEPLESEPVL 21647

Query: 587   RQLPHAPEHPVAT--LSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASV 643
                P+ P  P     ++T+ + ++ + W  P  DG S +I YI+E  +      +     
Sbjct: 21648 AVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKK 21707

Query: 644   DPKATSVTVKGLVPARSYQFRLCAVNDVG------KGQFSKDTERVSLPEEPPTAPPQNV 697
                     V GL     Y+FR+ A N  G         F K  + V  P      PP N 
Sbjct: 21708 TLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKP-----GPPGNP 21762

Query: 698   IASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDA---DVNNLLL 754
                  +  SI I W  P     + I  GY++   L   P   +++ +T        +  +
Sbjct: 21763 RVLDTSRSSISIAWNKPIYDGGSEIT-GYMVEIAL---PEEDEWQIVTPPAGLKATSYTI 21818

Query: 755   EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNA 814
               L     Y+I + A NS GLG     +   T +    + P  +  +A     +      
Sbjct: 21819 TGLTENQEYKIRIYAMNSEGLG--EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACC 21876

Query: 815   PSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFT--EYFTSVL 872
                 F+    +    + W  +  E +   +       ++ +  V  + +F   +Y  +V 
Sbjct: 21877 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLI--VGNVNRFDSGKYILTV- 21933

Query: 873   CFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRIS 931
                    G +S    VR   D PGP   L   E+  TS+ ++W  P    G  +  Y + 
Sbjct: 21934 ---ENSSGSKSAFVNVRVL-DTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVE 21989

Query: 932   WEEYNR-------TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 984
               E  R       TN   T         ++V  L    +Y   V A    G G + A T 
Sbjct: 21990 KRESTRKAYSTVATNCHKT--------SWKVDQLQEGCSYYFRVLAENEYGIG-LPAETA 22040

Query: 985   SSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLL 1043
              S    E P PP  + + ++   SV+L + +P +DG + I  ++VE Q       ++W  
Sbjct: 22041 ESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQ---TKGSDKWAT 22097

Query: 1044  IHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPA 1101
                +          +  L     YSFR+   N  G S P Q S  +  + L  PP     
Sbjct: 22098 CATVK----VTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLL 22153

Query: 1102  NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD-- 1159
               +    +   L +      ++ + G P      + + + +   K  + V  +  E +  
Sbjct: 22154 FNTFTVLAGEDLKV------DVPFIGRPTPA---VTWHKDNVPLKQTTRVNAESTENNSL 22204

Query: 1160  YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVR 1219
              TI+D          V+  N+ G    +  V+   +   P +GP  +  +  T+ S+ + 
Sbjct: 22205 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPG-PPTGPVKMDEV--TADSITLS 22261

Query: 1220  WSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYVLYEVQVLA 1278
             W   P+ D    +  Y V   EK   +   + +V    +R+  +   L     Y+ ++ A
Sbjct: 22262 WGP-PKYDGGSSINNYIV---EKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAA 22317

Query: 1279  FTRIGDGS--PSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQ 1335
               R G  +   S P + +     VPGPP   +       S+ + W  P +  G  ++ Y 
Sbjct: 22318 ENRYGKSTYLNSEPTVAQYPF-KVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYH 22376

Query: 1336  ITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTE 1395
             +  +   +       +   P  + +  TGL+    Y FR++A+   G G+ ++       
Sbjct: 22377 LERKERNSILWVKLNKTPIPQTK-FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYV- 22434

Query: 1396  KRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASV 1454
              RD   PP RP  +   V   SV L W +P  DG S +  Y ++ +ELP GRW + ++  
Sbjct: 22435 ARDPCDPPGRP--EAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRW-MKASFT 22491

Query: 1455  SHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHT 1514
             +   + F V  L     Y+FRV A N  G   FSE SES   + A  +  P  +S+ P  
Sbjct: 22492 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--VFSEPSESTGAITARDEVDPPRISMDPKY 22549

Query: 1515  TTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRG-FTLRGINNPGATWAELTSMYSM 1573
               ++++        K++  + G  I       + ++G   L           +  +  S+
Sbjct: 22550 KDTIVV--HAGESFKVDADIYGKPIP----TIQWIKGDQELSNTARLEIKSTDFATSLSV 22603

Query: 1574  RNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVH 1633
             ++  R     Y L   N      + ++V      GP   P                VV+ 
Sbjct: 22604 KDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGP----------------VVIS 22647

Query: 1634  GATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY 1693
             G TA +  + W+ PPL     DI  Y +   E  R  L   V    +   S K+  L   
Sbjct: 22648 GVTAEKCTLAWK-PPLQDGGSDIINYIVERRETSR--LVWTVVDANVQTLSCKVTKLLEG 22704

Query: 1694  TAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPN 1751
               Y   + A N  G G    S P   +     P AP + + + +T  S+ V WE P    
Sbjct: 22705 NEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDG 22764

Query: 1752  GI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT--- 1807
             G  + GY L       +    +      +    L L+V  L E   Y FR+ A+      
Sbjct: 22765 GSEILGYVLEKRDKEGI----RWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLS 22820

Query: 1808  -YGPEIEANVTTGPGEGAPGPPGVPIIVRYS-SAIAIHWSSG-DPGKGPITRYVIEARPS 1864
                P         P    PGPP  P ++  + S++ + WS     G   I  Y++E    
Sbjct: 22821 EPSPPSAYQKACDP-IYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDV 22879

Query: 1865  DEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909
               G W +     P  ++     ++ L     Y+FR+ A+N  G G
Sbjct: 22880 SVGEWTMCTP--PTGINKTNIEVEKLLEKHEYNFRICAINKAGVG 22922



 Score =  177 bits (449), Expect = 1e-43
 Identities = 292/1333 (21%), Positives = 502/1333 (37%), Gaps = 167/1333 (12%)

Query: 647   ATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGR-TNQ 705
             +T++  K      S  + L A N    G F+K    V + + P   PP+  +A    T++
Sbjct: 21516 STNLVNKDSTRRDSGAYTLTATNP---GGFAKHIFNVKVLDRP--GPPEGPLAVTEVTSE 21570

Query: 706   SIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNI-TDADVNNLLLEDLIIWTNYE 764
               ++ W PP +      +  YI++           + N+ ++  V  L +  L+    Y 
Sbjct: 21571 KCVLSWFPPLDDG-GAKIDHYIVQKRETSR---LAWTNVASEVQVTKLKVTKLLKGNEYI 21626

Query: 765   IEVAAYNSAGLG--VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFING 822
               V A N  G+G  + S  V      G P  PP N         ++   W  P       
Sbjct: 21627 FRVMAVNKYGVGEPLESEPVLAVNPYGPPD-PPKNPEVTTITKDSMVVCWGHPDS----- 21680

Query: 823   INQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPG-DG 880
              + G ++I +  E+ ++      + N +    + + VSGL +  EY   ++     G   
Sbjct: 21681 -DGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISA 21739

Query: 881   PRSTPQLVRTHEDV--PGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNR 937
             P  T    +  + V  PGP G+    +   +S+ ++W +P    G  +TGY +       
Sbjct: 21740 PSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEE 21799

Query: 938   TNTRVTHYLPNVTLE---YRVTGLTALTTYTIEVAAMTSKGQGQVSA-----STISSGVP 989
                ++    P   L+   Y +TGLT    Y I + AM S+G G+ +            +P
Sbjct: 21800 DEWQIV--TPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLP 21857

Query: 990   PELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
             PE+        +  I        F P         +W  +      GE  +   I   S+
Sbjct: 21858 PEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDH-----GESLDKASIESTSS 21912

Query: 1050  EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
                   + V ++N F    + +   N  G+       R + T   P D+      ++  +
Sbjct: 21913 YT---LLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDL-----KVKEVT 21964

Query: 1110  ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWT 1169
             +TS+ L W P P ++  G  +   Y ++  + +   K  S V  +  +  + ++ L+E  
Sbjct: 21965 KTSVTLTWDP-PLLD--GGSKIKNYIVE--KRESTRKAYSTVATNCHKTSWKVDQLQEGC 22019

Query: 1170  EYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSG----PTNVSALATTSSSMLVRWSEVPE 1225
              Y  +V A N  G G     +   T ESV +S     P  ++ +  T +S+ + W E PE
Sbjct: 22020 SYYFRVLAENEYGIG-----LPAETAESVKASERPLPPGKITLMDVTRNSVSLSW-EKPE 22073

Query: 1226  ADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDG 1285
              D    +LGY V  + K SD       V+      A +TGL +   Y  +V A    G  
Sbjct: 22074 HDGGSRILGYIVEMQTKGSDKWATCATVKVTE---ATITGLIQGEEYSFRVSAQNEKGIS 22130

Query: 1286  SPSH------------PP---ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI 1330
              P              PP   +L  T   + G  + +  P +   +  + W     P   
Sbjct: 22131 DPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVP--- 22187

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL 1390
                 + T R+N  +    ++  +  + R+           Y+ ++T       GEA E L
Sbjct: 22188 ---LKQTTRVNAESTENNSLLTIKDACREDVGH-------YVVKLTNSA----GEAIETL 22233

Query: 1391  VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSGRWAL 1449
              V     D+P PP+ P V+ ++V A S+ LSW P   DG S +  Y ++ R+  +  W +
Sbjct: 22234 NVIV--LDKPGPPTGP-VKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQI 22290

Query: 1450  HSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILS 1509
              SA+V+   ++    RLK    Y+FR+ A N  G S +     ++          P    
Sbjct: 22291 VSATVAR--TTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPV 22348

Query: 1510  VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 1569
             VT  +  S+ ++W  P  D  + ++                G+ L         W +L  
Sbjct: 22349 VTLSSRDSMEVQWNEPISDGGSRVI----------------GYHLERKERNSILWVKL-- 22390

Query: 1570  MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE--AVPTAAP 1627
                  N +    T+++   L +   YE R+S  N VG G  S   E +V      P   P
Sbjct: 22391 -----NKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRP 22445

Query: 1628  RNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKL 1687
               ++V   T   + + W+ P  D     I GY +   E   G   +   T  + +   ++
Sbjct: 22446 EAIIV---TRNSVTLQWKKPTYDG-GSKITGYIVEKKELPEGRWMKASFTNII-DTHFEV 22500

Query: 1688  KNLTGYTAYMVSVAAFNAAGDGPRSTPTQG----QTQQAAPSAPSSVKFSELTTTSVNVS 1743
               L     Y   V A NAAG     + + G    + +   P      K+ +        S
Sbjct: 22501 TGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGES 22560

Query: 1744  WEAPQFPNGILEGYRLVYEPCSPVDGV------SKIVTVDVKGNS-PLWLKVKDLAEGVT 1796
             ++      G         +P   +  +      S    +++K       L VKD     +
Sbjct: 22561 FKVDADIYG---------KPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDS 22611

Query: 1797  YRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSA--IAIHWSSG-DPGKGP 1853
               + ++AK       +  NV        PGPP  P+++   +A    + W      G   
Sbjct: 22612 GNYILKAKNVAGERSVTVNVKV---LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSD 22668

Query: 1854  ITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSS 1913
             I  Y++E R +   +W +    +   V + +  +  L  G  Y FR++AVN YG G    
Sbjct: 22669 IINYIVERRETSRLVWTV----VDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVG---E 22721

Query: 1914  PSQSVPAQKANPF 1926
             P +S P    NPF
Sbjct: 22722 PLESEPVVAKNPF 22734



 Score =  171 bits (433), Expect = 7e-42
 Identities = 352/1639 (21%), Positives = 604/1639 (36%), Gaps = 203/1639 (12%)

Query: 366   QISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL--------DSTVIDGM 417
             +++ L  D    F+ FARNAA  V   +      I  +    P         D  V+   
Sbjct: 25745 EVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAG 25804

Query: 418   SVV-LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
              V+ +  + +G P P I+W K + I      +    +      L +      D G Y   
Sbjct: 25805 EVLKINADIAGRPLPVISWAK-DGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLT 25863

Query: 477   ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGA 536
               N  G    + +  V  +     PP     I G  A   C ++          W +   
Sbjct: 25864 LKNVAGTRSVAVNCKVLDKPG---PPAGPLEINGLTAEK-CSLS----------WGRPQE 25909

Query: 537   TLGTESHPRIRLDRNGSLHISQT-WSGDIGTYTCRVIS-----------------AGGND 578
               G +    I +++  + H++ T   G++   +C+V                     G  
Sbjct: 25910 DGGADIDYYI-VEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEP 25968

Query: 579   SRSAHLRVRQLPHAPEHPVAT-LSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPW 636
               S  ++       P  P +  +++V + ++ L W++P  DG S +  YI+E  E N+  
Sbjct: 25969 LESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLR 26028

Query: 637   TVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT------ERVSLPEEPP 690
              V +         V   GL     Y++R+ A N  G    S+ +      + V LP  PP
Sbjct: 26029 WVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPS-PP 26087

Query: 691   TAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVN 750
             + P   ++ SG+T  +I I W  P        + GY + Y           K   D D  
Sbjct: 26088 SKP--KIVDSGKT--TITIAWVKPLFDG-GAPITGYTVEY-----------KKSDDTDWK 26131

Query: 751   NLL---------LEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAE 801
               +         +  L     Y   V + N  G    S        +     P  ++ +E
Sbjct: 26132 TSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSE 26191

Query: 802   ATNSTTIR----FTWNAPS-----PQFI-NGINQGYKLIAWEPEQEEEVTMVTARPNFQD 851
                +  ++    FT   P      P  + +  +   +  A+    +   ++     N  D
Sbjct: 26192 MRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRND 26251

Query: 852   SIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSL 911
             S          K+T    +VL          ++  LV    D PGP  +++  ++   S 
Sbjct: 26252 S---------GKYTLTIQNVLS--------AASLTLVVKVLDTPGPPTNITVQDVTKESA 26294

Query: 912   KVSWQEPGEKNGI-LTGYRISWEEYNRTN-TRVTHYLPNVTLEYRVTGLTALTTYTIEVA 969
              +SW  P    G  +  Y I   E ++     VT+      L Y+VT L     Y   V+
Sbjct: 26295 VLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNR--LSYKVTNLQEGAIYYFRVS 26352

Query: 970   AMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLV 1028
                  G G + A T       E P PP  LG+++I   SV+L + +P +DG + I  ++V
Sbjct: 26353 GENEFGVG-IPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV 26411

Query: 1029  EAQVGVVGEGEE-WLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSR 1087
             EA    + +G++ W+      +        V  L   + Y FR+   N  G S P +   
Sbjct: 26412 EA----LEKGQKNWVKCAVAKSTHHV----VSGLRENSEYFFRVFAENQAGLSDPRE--- 26460

Query: 1088  KIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY--NGNPESVGYKIKYSRSDGHG 1145
              +  +     + P  + ++     ++++R     +++   +G P     K+  SR     
Sbjct: 26461 LLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLP---KVTLSRDGVPL 26517

Query: 1146  KTLSHVVQDRVERDYTIEDLEEWTEY--RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGP 1203
             K       +    + TI   E  T    R ++ A N+ G+      +V   R   P +GP
Sbjct: 26518 KATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPG-PPTGP 26576

Query: 1204  TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQL 1263
               +S +  T  S+ ++W E P+ D    V  Y ++ +E  +            +      
Sbjct: 26577 VVISDI--TEESVTLKW-EPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMK 26633

Query: 1264  TGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLD-DVPGPPMGILFPEVRTTSVRLIWQ 1322
                G+   Y+ ++ A  R G         +   L    PGPP       V   S+ + W 
Sbjct: 26634 LTTGEE--YQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWH 26691

Query: 1323  PPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382
              P +  G  +        +  +        L      +  T +    +Y FR+ A+   G
Sbjct: 26692 EPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAG 26751

Query: 1383  WGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRE 1441
              G+ +          D  +PP    V+  D+   SV LSW+ P  DG S +  Y ++ R+
Sbjct: 26752 VGKPSHPSEPVLAI-DACEPPRN--VRITDISKNSVSLSWQQPAFDGGSKITGYIVERRD 26808

Query: 1442  LPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501
             LP GRW   S + +   + FI+  L   + Y+FRV A N +G    S  SE +  +    
Sbjct: 26809 LPDGRWTKASFT-NVTETQFIISGLTQNSQYEFRVFARNAVGS--ISNPSEVVGPITCID 26865

Query: 1502  DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
                  ++ + P   T V                    ++YR      LR   + G   P 
Sbjct: 26866 SYGGPVIDL-PLEYTEV--------------------VKYRAGTSVKLRA-GISGKPAPT 26903

Query: 1562  ATW------AELTSMYSMRNLSR-PSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQ 1614
               W       +  ++  + N +   S+   + D LN    YE+++   NA+G   ++   
Sbjct: 26904 IEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGC-YELKLR--NAMGSASATIRV 26960

Query: 1615  EVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTER 1674
             ++ + +  P   P  +     TA ++ + W PP  D       G KI  +  ++   +  
Sbjct: 26961 QI-LDKPGPPGGP--IEFKTVTAEKITLLWRPPADDG------GAKITHYIVEKRETSRV 27011

Query: 1675  VKTLF---LAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSS 1729
             V ++    L E  +    +     Y+  V A N  G G    S     +     P  P  
Sbjct: 27012 VWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI 27071

Query: 1730  VKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKV 1788
              + +++T  S+ V W  P    G  + GY L       + G  K++   ++       KV
Sbjct: 27072 PEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSL-GWFKVLKETIRDTRQ---KV 27127

Query: 1789  KDLAEGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGAPGPPGVPIIVRYS----SAIAIH 1843
               L E   Y++R+ A      GP  E +      +    PPG P  +R +    S+I + 
Sbjct: 27128 TGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPID-PPGPPAKIRIADSTKSSITLG 27186

Query: 1844  WSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
             WS     G   +T YV+E R  +E  W  +      EV +  + +  LKPGV+Y FRV A
Sbjct: 27187 WSKPVYDGGSAVTGYVVEIRQGEEEEWTTV--STKGEVRTTEYVVSNLKPGVNYYFRVSA 27244

Query: 1903  VNDYGFGTPSSPSQSVPAQ 1921
             VN  G G P   ++ V A+
Sbjct: 27245 VNCAGQGEPIEMNEPVQAK 27263



 Score =  167 bits (423), Expect = 1e-40
 Identities = 305/1309 (23%), Positives = 495/1309 (37%), Gaps = 158/1309 (12%)

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLAS 642
             +++ + P  PE    T  ++ + +++LTW KP  DG S ++ Y++E  E      V  A 
Sbjct: 26369 VKITEKPSPPEKLGVT--SISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAV 26426

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE--EPPTAPPQN---- 696
                K+T   V GL     Y FR+ A N  G     +    V + E  EPP    +N    
Sbjct: 26427 A--KSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSH 26484

Query: 697   ---VIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLL 753
                V A       I I  +P P+           +     G+P+    +  T+    NL 
Sbjct: 26485 TVYVRAGSNLKVDIPISGKPLPK-----------VTLSRDGVPLKATMRFNTEITAENLT 26533

Query: 754   --LEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 811
               L++ +       E+ A NS+G       +      G PT P   V        ++   
Sbjct: 26534 INLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGP---VVISDITEESVTLK 26590

Query: 812   WNAPSPQFINGINQGYKLIAWEPEQEE----EVTMVTARPNFQDSIHVGFVSGLKKFTEY 867
             W  P     +G +Q    I  + E       EV+   AR   +       V  L    EY
Sbjct: 26591 WEPPK---YDGGSQVTNYILLKRETSTAVWTEVSATVARTMMK-------VMKLTTGEEY 26640

Query: 868   FTSVLCFTTPG--DGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG-I 924
                +      G  D   S    V+     PGP      + +   S+ V W EP    G  
Sbjct: 26641 QFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA 26700

Query: 925   LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 984
             + GY +  ++ N    +  + L   T  ++VT ++A   Y   V A  + G G+ S  + 
Sbjct: 26701 VVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPS- 26759

Query: 985   SSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLL 1043
                +  +   PP N+ I++I   SV+L ++ P +DG + I+ ++VE +    G   +   
Sbjct: 26760 EPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTK--- 26816

Query: 1044  IHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGT-SPPSQ---PSRKIQTLQAPPDMA 1099
                 +N  + + + +  L   + Y FR+   N VG+ S PS+   P   I +   P    
Sbjct: 26817 -ASFTNVTETQFI-ISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDL 26874

Query: 1100  PANVS--LRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVE 1157
             P   +  ++  + TS+ LR         +G P      I++ + D   +T + V  +   
Sbjct: 26875 PLEYTEVVKYRAGTSVKLR------AGISGKPAPT---IEWYKDDKELQTNALVCVENTT 26925

Query: 1158  --RDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV-VGRTRESVPSSGPTNVSALATTSS 1214
                   I+D +       +++  NA+GS   S T+ V    +  P  GP     +     
Sbjct: 26926 DLASILIKDADRLNSGCYELKLRNAMGSA--SATIRVQILDKPGPPGGPIEFKTVTAEKI 26983

Query: 1215  SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTG--LGKYVLY 1272
             ++L R    P AD  G  + + ++ K + S      W +         +T   + K   Y
Sbjct: 26984 TLLWR----PPADDGGAKITHYIVEKRETSRV---VWSMVSEHLEECIITTTKIIKGNEY 27036

Query: 1273  EVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI- 1330
               +V A  + G G P     ++ +     PGPP      ++   S+ ++W  P A  G  
Sbjct: 27037 IFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSD 27096

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEA- 1389
             I  Y +  R   +      ++      RQ   TGL   S Y +R+ A    G G  +E  
Sbjct: 27097 ISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQGPFSEPS 27155

Query: 1390  -LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRW 1447
                   +  D P PP++  ++  D    S+ L W +P  DG S V  Y ++ R+     W
Sbjct: 27156 EFYKAADPIDPPGPPAK--IRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEW 27213

Query: 1448  ALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI 1507
                S       + ++V  LKP  +Y FRV A N  G  E  E +E +        EAP I
Sbjct: 27214 TTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDIL--EAPEI 27271

Query: 1508  LSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAE- 1566
               +     TSV+ +     ED    +L+ F                 +G   P  TW + 
Sbjct: 27272 -DLDVALRTSVIAK---AGEDV--QVLIPF-----------------KGRPPPTVTWRKD 27308

Query: 1567  -----LTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEA 1621
                    + YS+ N    SL        N   +Y   +++ N VGE P S    V V + 
Sbjct: 27309 EKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY--ILTIENGVGE-PKSSTVSVKVLD- 27364

Query: 1622  VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLF-- 1679
              P A  +  V H +  T + + W+PP +D       G  I  +  ++ + T+R  ++   
Sbjct: 27365 TPAACQKLQVKHVSRGT-VTLLWDPPLIDG------GSPIINYVIEKRDATKRTWSVVSH 27417

Query: 1680  -LAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
               +  S KL +L+  T +   V A N  G G     T+       P+    +   + T T
Sbjct: 27418 KCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKT 27477

Query: 1739  SVNVSWEAPQFPNGILEGYRLVY-----EPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAE 1793
             SV +SW  P F  G +    +V      E      G+SK   ++          V  L E
Sbjct: 27478 SVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIE----------VSQLKE 27527

Query: 1794  GVTYRFRIRAKT-------FTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
                  FR+ AK         T GP     +   P       PG  + VR
Sbjct: 27528 QSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVR 27576



 Score =  164 bits (414), Expect = 1e-39
 Identities = 332/1511 (21%), Positives = 556/1511 (36%), Gaps = 169/1511 (11%)

Query: 473   YTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRY--- 529
             +   A N +G+ +      +  +  I  P  D S I G Q ++  G  H+  + + Y   
Sbjct: 27533 FRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIG--HNVHLELPYKGK 27590

Query: 530   -----IWEKDGATLGTESHPRIRLDRNG-SLHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
                   W KDG  L      R     N  +L I        G YT  + +A    +    
Sbjct: 27591 PKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT 27650

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAP-WTVLLA 641
             +     P  P+ P+     ++  ++ L+W  P D G   +  Y +E  E +   W ++ +
Sbjct: 27651 VITLGPPSKPKGPIR-FDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCS 27709

Query: 642   SVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASG 701
             SV    T+  V  LV    YQFR+ A N  G  Q    +  V+  +     PP   +   
Sbjct: 27710 SV--ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 27767

Query: 702   RTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWT 761
              T+  + + W  P     + +   ++ +       + +Q  N +           L+   
Sbjct: 27768 VTSDGMSLTWDAPVYDGGSEVTGFHVEKK--ERNSILWQKVNTSPISGREYRATGLVEGL 27825

Query: 762   NYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFIN 821
             +Y+  V A NSAGL   S   +++TL   P  PPG          TI   WN P      
Sbjct: 27826 DYQFRVYAENSAGLSSPSDP-SKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLR---- 27880

Query: 822   GINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPG-- 878
               + G K++ +  E+ +       R NF D     + V+GL     Y   ++     G  
Sbjct: 27881 --DGGSKIVGYSIEKRQGNER-WVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTI 27937

Query: 879   DGPRSTPQLVRTHEDVPGPV---GHLSFSEIL---DTSLKVSWQEPGEKNGILTGYRISW 932
               P  +  ++ T ++   P+   G   F  ++     SL++     G     +T ++   
Sbjct: 27938 SPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGV 27997

Query: 933   EEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992
             E   R N  +T  L + +L  R         YT+E  A  + G  +          P ++
Sbjct: 27998 EIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVE--AKNASGSAKAEIKVKVQDTPGKV 28055

Query: 993   PGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
              GP   +  +NI    +TL +  P  DG   I+ +++E +         W LI    ++ 
Sbjct: 28056 VGP---IRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRET---SRLAWALIE---DKC 28106

Query: 1052  DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111
             +A+S     L     Y FR+  VN  G   P      +  +Q     AP        +  
Sbjct: 28107 EAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGN 28166

Query: 1112  SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV--ERDYTIEDLEEWT 1169
             S+ L W      E +G  E   Y ++  R +        V+  R   E  + +  L E  
Sbjct: 28167 SITLTWA---RPESDGGSEIQQYILE--RREKKSTRWVKVISKRPISETRFKVTGLTEGN 28221

Query: 1170  EYRVQVQAFNAIGSGPWSQ-TVVGRTRESV-PSSGPTNVSALATTSSSMLVRWSEVPEAD 1227
             EY   V A NA G GP S  + + + RE V P   PT V    T+ +++ + WS+ P  D
Sbjct: 28222 EYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSK-PVFD 28280

Query: 1228  RNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 1287
                 ++GY +   + D     +    E        +T L     Y+ +V A    G G  
Sbjct: 28281 GGMEIIGYIIEMCKADLGDWHKV-NAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDS 28339

Query: 1288  SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQ-------ITHRL 1340
                    + +D +  P + I     +T  VR       A   + +AYQ       +  + 
Sbjct: 28340 CEVTGTIKAVDRLTAPELDIDANFKQTHVVRA-----GASIRLFIAYQGRPTPTAVWSKP 28394

Query: 1341  NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRP 1400
             ++  +  A +     S    T           + +T +   G    ++++  T +  D P
Sbjct: 28395 DSNLSLRADIHT-TDSFSTLTVENCNRNDAGKYTLTVENNSG----SKSITFTVKVLDTP 28449

Query: 1401  QPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNAS 1459
              PP    +  +DV   S  L W+ P  DG + + +Y ++ RE     W + S   +    
Sbjct: 28450 GPPGP--ITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQI- 28506

Query: 1460  SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLT-TLQAAPDEAPTILSVTPHTTTSV 1518
              F V+ L     Y FRV A N+ G  E  E  E +  T Q AP   P  L V   + +S 
Sbjct: 28507 -FKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAP---PRRLDVVDTSKSSA 28562

Query: 1519  LIRWQPPAED---KINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
             ++ W  P  D   +I G LL  R +  +   E   G T            +LT       
Sbjct: 28563 VLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA--GHT-----------KQLT------- 28602

Query: 1576  LSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV------PTA---- 1625
                     + ++ L +   YE R+   N  G    S P+E F    +      PTA    
Sbjct: 28603 --------FTVERLVEKTEYEFRVKAKNDAGY---SEPREAFSSVIIKEPQIEPTADLTG 28651

Query: 1626  -APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTE-RVKTLFLAEN 1683
                + +     +   +DV     P       ++  ++   E  R ++T  + +T    ++
Sbjct: 28652 ITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLK--ETDRVSITTTKDRTTLTVKD 28709

Query: 1684  SVK---------LKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSE 1734
             S++         L+N  G   + V+V      G      P  G  + ++ SA S V    
Sbjct: 28710 SMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPG------PVTGPIEVSSVSAESCV---- 28759

Query: 1735  LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
                    +SW  P+   G  E    + E         ++V   VK      +KV  L + 
Sbjct: 28760 -------LSWGEPKDGGGT-EITNYIVEKRESGTTAWQLVNSSVKRTQ---IKVTHLTKY 28808

Query: 1795  VTYRFRIRAKT-FTYGPEIE-ANVTTGPGEGAPGPPGVPIIVRYSS-AIAIHWSSG-DPG 1850
             + Y FR+ ++  F     +E A +        P  P  P +   S+ A++I W      G
Sbjct: 28809 MEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDG 28868

Query: 1851  KGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGT 1910
                I  Y +E +  +  LW   +K+         + +  L  G+ Y FR  A+N  G   
Sbjct: 28869 GSKIIGYWVEKKERNTILW---VKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSK 28925

Query: 1911  PSSPSQSVPAQ 1921
              S  S+ + AQ
Sbjct: 28926 ASEASRPIMAQ 28936



 Score =  161 bits (408), Expect = 6e-39
 Identities = 283/1169 (24%), Positives = 437/1169 (37%), Gaps = 141/1169 (12%)

Query: 412   TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLI-SPTHISDA 470
             T+  G S+ L    SG P P ITW K    LAS ++        ES SLLI    +  DA
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAI----IDTTESYSLLIVDKVNRYDA 29512

Query: 471   GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV----- 525
             G YT  A N  G   A+  + V+     T  P     +K      V      P +     
Sbjct: 29513 GKYTIEAENQSGKKSATVLVKVYD----TPGPCPSVKVKEVSRDSVTITWEIPTIDGGAP 29568

Query: 526   TIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVI-----SAGGNDSR 580
                YI EK  A +        +  +     IS    G +  Y  RV+       G     
Sbjct: 29569 VNNYIVEKREAAMRAFKTVTTKCSKT-LYRISGLVEGTM--YYFRVLPENIYGIGEPCET 29625

Query: 581   SAHLRVRQLPHAPEHPVATLSTVE--RRAINLTWTKP-FDGNSPLIRYILEMSENNAPWT 637
             S  + V ++P  P    A L  V+  +  + L W KP +DG S L  Y+LE  +      
Sbjct: 29626 SDAVLVSEVPLVP----AKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERW 29681

Query: 638   VLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVS------LPEEPPT 691
             + + ++ P     TV  L     Y FR+ A N+ G  +  +    V+      LP    +
Sbjct: 29682 MKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLS 29741

Query: 692   APPQNVI--ASGRTNQSIM-IQWQPPPESHQNGILKGYIIRYCLAG--LPVGYQFKNITD 746
               PQ  I   +GR  + ++ I  +PPP +            +  AG  L    +    T 
Sbjct: 29742 TMPQKTIHVPAGRPVELVIPIAGRPPPAAS-----------WFFAGSKLRESERVTVETH 29790

Query: 747   ADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNST 806
               V  L + +  I    E  +   N  G    + KV      G PT P   +  +  ++T
Sbjct: 29791 TKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP---IKIDEIDAT 29847

Query: 807   TIRFTWNAPSPQFINGINQGYKLIAWEPEQEEE-------VTMVTARPNFQDSIHVGFVS 859
             +I  +W  P       ++ G  L  +  EQ +        V+    R  F+        +
Sbjct: 29848 SITISWEPPE------LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFK-------FT 29894

Query: 860   GLKKFTEYFTSVLCFTTPGDGPRSTPQLV--RTHEDVPGPVGHLSFSEILDTSLKVSWQE 917
              L +  EY   V      G G     +++  R+   +PGP   L   ++    + ++W  
Sbjct: 29895 RLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYP 29954

Query: 918   PGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQ 976
             P +  G  +TGY +  +E         + +P     YR TGLT    Y   V A+ ++G 
Sbjct: 29955 PEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGS 30014

Query: 977   GQVS--ASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVG 1033
             G+ S  +  I +  P   PG P N  +++    SV+L +  P  +G + ++ +L+E Q  
Sbjct: 30015 GKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKV 30074

Query: 1034  VVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP--SRKIQT 1091
                +  EW   +    +   R   +  L     Y FR+   N  G   P++   + K+  
Sbjct: 30075 ---DQHEWTKCNTTPTK--IREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTE 30129

Query: 1092  LQAPPDMA-----PANVSLRTASETSLWL--RWMPLPEMEYNGNPESVGYKIKYSRSDGH 1144
             +   PD          + +R      L +  +  P P  ++    + +  +   + S+ H
Sbjct: 30130 MLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETH 30189

Query: 1145  GKTLSHVVQDRVERDYTIEDL--EEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSS- 1201
              +    V+++    D    DL  E     +        IGS               P+S 
Sbjct: 30190 TEL---VIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS---------------PNSP 30231

Query: 1202  -GPTNVSALATTSSSMLVRWSEVPEADRNGL-VLGYKVMYKEKDSDTQPRFWLVEGNSSR 1259
              GP     +   S    VR S  P AD  G  +LGY +  +E         W    +  R
Sbjct: 30232 EGPLEYDDIQVRS----VRVSWRPPADDGGADILGYILERREVPKAA----WYTIDSRVR 30283

Query: 1260  SAQLT--GLGKYVLYEVQVLAFTRIGDGSP--SHPPILERTLDDVPGPPMGILFPEV--- 1312
                L   GL + V Y  +V A  + G   P  S  P+  +T  + P PP     PEV   
Sbjct: 30284 GTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNP--PEVLDV 30341

Query: 1313  RTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYL 1372
               +SV L W  P    G  +      R  T+T           +   YT TGL P++ Y 
Sbjct: 30342 TKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQ 30401

Query: 1373  FRITAQTRKGWGEAAEAL--VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGL 1429
             FRI AQ   G  E + A   VV  +  D+P  P    ++   +   SV L WE P  DG 
Sbjct: 30402 FRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGE--LEILSISKDSVTLQWEKPECDGG 30459

Query: 1430  SPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE 1489
               +  Y ++ R+     W   S         F +  L   T Y+FRV A N+ G S    
Sbjct: 30460 KEILGYWVEYRQSGDSAWK-KSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 30518

Query: 1490  ESESLTTLQAAPDEAPTILSVTPHTTTSV 1518
              + S+ T +    EAP I       TT +
Sbjct: 30519 TAMSIKT-KLTSGEAPGIRKEMKDVTTKL 30546



 Score =  158 bits (400), Expect = 5e-38
 Identities = 355/1546 (22%), Positives = 567/1546 (36%), Gaps = 189/1546 (12%)

Query: 334   GVPPPSITWYKDAAVVEVEKLTRFRQRND-GGLQISGLVPDDTGMFQCFARNAAGEVQTS 392
             G P P+I WYKD   ++   L       D   + I      ++G ++   RNA G    +
Sbjct: 26898 GKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASAT 26957

Query: 393   TYLAVTSIAPNITRGPLDSTVIDGMSVVL----ACETSGAPRPAITWQKGERILASGSVQ 448
               + +    P    GP++   +    + L      +  GA       +K E      S+ 
Sbjct: 26958 IRVQILD-KPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMV 27016

Query: 449   LPRFTPLESGSLLISPTHISDAGTY--TCLATNSRGVDE-ASADLVVWARTRITK-PPQD 504
                         +I+ T I     Y     A N  G+ E   +D VV     +T  PP  
Sbjct: 27017 SEHLE-----ECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI 27071

Query: 505   QSVIKGTQASMVCGVTH-----DPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQT 559
               V K T+ SM    +         ++  ++ ++D  +LG     +  +          T
Sbjct: 27072 PEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLT 27131

Query: 560   WSGDIGTYTCRVISAG-GNDSRSAHLRVRQLPHAPEHPVATLSTVE--RRAINLTWTKP- 615
              + D     C V +AG G  S  +       P  P  P A +   +  + +I L W+KP 
Sbjct: 27132 ENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPV 27191

Query: 616   FDGNSPLIRYILEMSE-NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKG 674
             +DG S +  Y++E+ +     WT +    + + T   V  L P  +Y FR+ AVN  G+G
Sbjct: 27192 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 27251

Query: 675   QFSKDTERVSLPE--EPP-----TAPPQNVIASGRTNQSIMIQW--QPPPESHQNGILKG 725
             +  +  E V   +  E P      A   +VIA    +  ++I +  +PPP        K 
Sbjct: 27252 EPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKN 27311

Query: 726   YIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEW 785
                     G    Y  +N    D ++LL    +   +    +    + G+G   S     
Sbjct: 27312 -------LGSDARYSIEN---TDSSSLLTIPQVTRNDTGKYILTIEN-GVGEPKSSTVSV 27360

Query: 786   TLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTA 845
              +   P      +  +  +  T+   W+ P       I+ G  +I +  E+ +      +
Sbjct: 27361 KVLDTPAACQ-KLQVKHVSRGTVTLLWDPPL------IDGGSPIINYVIEKRDATKRTWS 27413

Query: 846   RPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFS 904
               + + S     +  L + T +F  VL     G G P  T + V+  E VP P+  LS  
Sbjct: 27414 VVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAE-VPAPIRDLSMK 27472

Query: 905   EILDTSLKVSWQEPGEKNG-ILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTT 963
             +   TS+ +SW +P    G ++T Y +  E   +     +H   + T E  V+ L   + 
Sbjct: 27473 DSTKTSVILSWTKPDFDGGSVITEYVV--ERKGKGEQTWSHAGISKTCEIEVSQLKEQSV 27530

Query: 964   YTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPG------Y 1017
                 V A   KG       TI      EL   P  + +S+I    VT++          Y
Sbjct: 27531 LEFRVFAKNEKGLS--DPVTIGPITVKELIITP-EVDLSDIPGAQVTVRIGHNVHLELPY 27587

Query: 1018  DGKTSIS-RW------LVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFR 1070
              GK   S  W      L E++     + E  + +   + + +        L+   C    
Sbjct: 27588 KGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRI-- 27645

Query: 1071  MRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPE 1130
                + ++   PPS+P   I+  +   D              S+ L W  +P  E NG  E
Sbjct: 27646 AVPITVITLGPPSKPKGPIRFDEIKAD--------------SVILSW-DVP--EDNGGGE 27688

Query: 1131  SVGYKI-KYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPW-S 1187
                Y I K   S  + K +   V       + + +L +  EY+ +V+A N  G S P  S
Sbjct: 27689 ITCYSIEKRETSQTNWKMVCSSV---ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVS 27745

Query: 1188  QTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDS--- 1244
               +V + +  +P   P        TS  M + W + P  D    V G+ V  KE++S   
Sbjct: 27746 SIIVAKHQFRIPGP-PGKPVIYNVTSDGMSLTW-DAPVYDGGSEVTGFHVEKKERNSILW 27803

Query: 1245  ---DTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLD--D 1299
                +T P        S R  + TGL + + Y+ +V A    G  SPS P      +   D
Sbjct: 27804 QKVNTSP-------ISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVD 27856

Query: 1300  VPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQITHRL-NTTTANTATVEVLAPSA 1357
              PG P  I   +V   ++ L W PP    G  I+ Y I  R  N         +V   S 
Sbjct: 27857 PPGTPDYI---DVTRETITLKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDV---SE 27910

Query: 1358  RQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARS 1417
              QYT TGL P   Y FRI A+   G              RD   P   P+V+        
Sbjct: 27911 CQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP---PIVEFGPEYFDG 27967

Query: 1418  VLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSY----- 1472
             +++       G S      +Q R +P   W      +    +  I D L   + +     
Sbjct: 27968 LII-----KSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDAT 28022

Query: 1473  -----KFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAE 1527
                   + V+A N  G    S ++E    +Q  P +    +  T  T   + + W  P  
Sbjct: 28023 RDHRGVYTVEAKNASG----SAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLN 28078

Query: 1528  DKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELD 1587
             D    I   + I  RE                    WA +            S T  +L 
Sbjct: 28079 DGCAPI-THYIIEKRE---------------TSRLAWALIED-----KCEAQSYTAIKLI 28117

Query: 1588  NLNKHRRYEIRMSVYNAVGEGP--SSPPQEVFVGEAVPTA----APRNVVVHGATATQLD 1641
             N N+   Y+ R+S  N  G G    S P    +   VP A     P N+     T   + 
Sbjct: 28118 NGNE---YQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNI-----TGNSIT 28169

Query: 1642  VTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVA 1701
             +TW  P  D    +IQ Y +   E +     + +    ++E   K+  LT    Y   V 
Sbjct: 28170 LTWARPESDG-GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 28228

Query: 1702  AFNAAGDGPRSTPT---QGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGY 1757
             A NAAG GP S  +   + +     P  P+ VK ++ + T+V++ W  P F  G+ + GY
Sbjct: 28229 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 28288

Query: 1758  RLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 1803
               + E C     +     V+ +        V DL  G  Y+FR+ A
Sbjct: 28289 --IIEMCKA--DLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSA 28330



 Score =  158 bits (399), Expect = 6e-38
 Identities = 319/1434 (22%), Positives = 534/1434 (37%), Gaps = 160/1434 (11%)

Query: 531   WEKDGATLGTESHPRIRLD-RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
             W KD A +  +    I+      +L   +    D G Y   V ++ G+      + V   
Sbjct: 16852 WFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDR 16911

Query: 590   PHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLASVDPKAT 648
             P  P  PV+    V +  + ++W  P D G S +  YI+E  E      + + S   K T
Sbjct: 16912 PGPPVGPVS-FDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAK-T 16969

Query: 649   SVTVKGLVPARSYQFRLCAVNDVG-KGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSI 707
             +  V  L+  + Y FR+ A N  G       D+ +       P AP Q ++    T  S 
Sbjct: 16970 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEV-TKDSA 17028

Query: 708   MIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNITDADVN---NLLLEDLIIWTNY 763
             ++ W  P   H  G  +  YI+        +  ++  +T   ++      + DL+    Y
Sbjct: 17029 LVTWNKP---HDGGKPITNYILE---KRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQY 17082

Query: 764   EIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFIN 821
             E  V+A N  G+G  S  SK            PP N  A  T   ++  TW  P     +
Sbjct: 17083 EFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGS 17142

Query: 822   GINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDG- 880
              I  GY ++ ++   +EE       P          V+GL+    Y   VL     G+  
Sbjct: 17143 KI-LGY-IVEYQKVGDEEWRRANHTPESCPETKYK-VTGLRDGQTYKFRVLAVNAAGESD 17199

Query: 881   PRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGY---RISWEEYNR 937
             P   P+ V   + +  P   L  +   +  +KV   +    + I+ G    +++W++ +R
Sbjct: 17200 PAHVPEPVLVKDRLEPPELILDANMAREQHIKVG--DTLRLSAIIKGVPFPKVTWKKEDR 17257

Query: 938   ---TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGV-PPELP 993
                T  R+        LE R         Y++ V       +    + T+S  V   + P
Sbjct: 17258 DAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTV-------ENPAGSKTVSVKVLVLDKP 17310

Query: 994   GPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPD 1052
             GPP +L +S I   S  L ++ P  DG + I+ ++VE +        +W     LS    
Sbjct: 17311 GPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVA---SAQW---SPLSATSK 17364

Query: 1053  ARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ-APPDMAPANVSLRTASET 1111
              +S     LN    Y FR+   N  G  P  +  + I+ L    P   P ++      +T
Sbjct: 17365 KKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKT 17424

Query: 1112  SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHG----KTLSHVVQDRVERDYTIEDLEE 1167
              + L W    + + +G     GY ++Y           KT++++       +  +  L++
Sbjct: 17425 EVSLVW---NKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNL-------ECVVTGLQQ 17474

Query: 1168  WTEYRVQVQAFNAIGSGPWSQTVVGRTRES-VPSSGPTNVSAL--------ATTSSSMLV 1218
                YR +V+A N +G G    T+    +E  VP S   +V  +         T     ++
Sbjct: 17475 GKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAII 17534

Query: 1219  RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA 1278
             R   VP A         K      +  T   + +   N S    +    +    E Q+  
Sbjct: 17535 RGVPVPTA---------KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQI-- 17583

Query: 1279  FTRIGDGSPSHPPILERTLDDVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIILAYQIT 1337
                + + + S    +  T+ DVPGPP G I   +V    + + WQPP    G  +   I 
Sbjct: 17584 --TVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIV 17641

Query: 1338  HRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VVTTEK 1396
              +   T  +T  V     S  +     L+    Y+FR+ A+ + G G   ++   V   K
Sbjct: 17642 EK-QDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHK 17700

Query: 1397  RDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVS 1455
                P PP +P+V   D+   +  +SW  P SDG SP+  Y ++ RE+ +G+W   + +  
Sbjct: 17701 FSPPSPPGKPVV--TDITENAATVSWTLPKSDGGSPITGYYMERREV-TGKWVRVNKTPI 17757

Query: 1456  HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-LSVTPHT 1514
              +   F V  L    +Y+FRV A N  G S+ S  S+ +   +      P I   +   +
Sbjct: 17758 ADL-KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKS 17816

Query: 1515  TTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMR 1574
               +  + W  P  D  + IL                G+ +       A W  +     +R
Sbjct: 17817 RETADLVWTKPLSDGGSPIL----------------GYVVECQKPGTAQWNRINKDELIR 17860

Query: 1575  NLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV--PTAAPRNVVV 1632
               +      + +  L +   Y  R+   N VGEG      E  + + +  P     +V  
Sbjct: 17861 QCA------FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTC 17914

Query: 1633  HGATATQLDVTW----------EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
                   ++  T           EP    ++ G +           R    + ++ L   E
Sbjct: 17915 RDVITVRVGQTIRILARVKGRPEPDITWTKEGKV---------LVREKRVDLIQDLPRVE 17965

Query: 1683  NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
               +K      +  Y++S  A N++G    S       +   P    ++K + +T  +  +
Sbjct: 17966 LQIKEAVRADHGKYIIS--AKNSSGHAQGSAIVNVLDR---PGPCQNLKVTNVTKENCTI 18020

Query: 1743  SWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIR 1802
             SWE P   NG  E    + E   P      IV  DV   +   +K   LA    Y FR+ 
Sbjct: 18021 SWENP-LDNGGSEITNFIVEYRKPNQKGWSIVASDV---TKRLIKANLLANN-EYYFRVC 18075

Query: 1803  AKT-FTYGPEIEA-------NVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD-PGKGP 1853
             A+     GP IE        N    PGE    P  + I  +  + + + W   D  G  P
Sbjct: 18076 AENKVGVGPTIETKTPILAINPIDRPGE----PENLHIADKGKTFVYLKWRRPDYDGGSP 18131

Query: 1854  ITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG 1907
                Y +E R      W+ + K   KE     + +D       Y+FRV   N+ G
Sbjct: 18132 NLSYHVERRLKGSDDWERVHKGSIKETH---YMVDRCVENQIYEFRVQTKNEGG 18182



 Score =  158 bits (399), Expect = 6e-38
 Identities = 293/1278 (22%), Positives = 490/1278 (38%), Gaps = 155/1278 (12%)

Query: 302   LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW-YKDAAVVEVEKLTRFRQR 360
             L VL        P++ I     + V++     G PPP+ +W +  + + E E++T     
Sbjct: 29732 LRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHT 29791

Query: 361   NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
                 L I      DTG +    +N  G   + T   +    P    GP+    ID  S+ 
Sbjct: 29792 KVAKLTIRETTIRDTGEYTLELKNVTG-TTSETIKVIILDKPGPPTGPIKIDEIDATSIT 29850

Query: 421   LACE----TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISP---THISDAGTY 473
             ++ E      GAP           ++       P + P+ S S+  S    T +++   Y
Sbjct: 29851 ISWEPPELDGGAPLSGY-------VVEQRDAHRPGWLPV-SESVTRSTFKFTRLTEGNEY 29902

Query: 474   T--CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIW 531
                  ATN  G+       V+  R+ I  P   +++        +  V+ D      Y  
Sbjct: 29903 VFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETL-------QIFDVSRDGMTLTWYPP 29955

Query: 532   EKDGATLGT---ESHPRIRLD---RNGSLHISQTWSGDIG-----TYTCRVIS----AGG 576
             E DG +  T        +R D   R   + ++ T     G      Y  RV +      G
Sbjct: 29956 EDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSG 30015

Query: 577   NDSRSAHLRVRQLPHA----PEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSE 631
               SR +   V   P A    P++P  T +T  R +++L W+ P D G S +  Y++EM +
Sbjct: 30016 KPSRPSKPIVAMDPIAPPGKPQNPRVTDTT--RTSVSLAWSVPEDEGGSKVTGYLIEMQK 30073

Query: 632   NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFS------KDTERVSL 685
              +        +   K    T+  L     Y+FR+ A N  G G+ +      K TE +  
Sbjct: 30074 VDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEY 30133

Query: 686   PEEPPTAPPQN---VIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFK 742
             P+       Q    V   G    +I I+ +P P           I ++   G  +  +  
Sbjct: 30134 PDYELDERYQEGIFVRQGGVIRLTIPIKGKPFP-----------ICKWTKEGQDISKRAM 30182

Query: 743   NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEA 802
               T      L++++     +   ++   N  G      KV    + G P  P G +  + 
Sbjct: 30183 IATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKV---RVIGSPNSPEGPLEYDD 30239

Query: 803   TNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEE--EVTMVTARPNFQDSIHVGFVSG 860
                 ++R +W  P+       + G  ++ +  E+ E  +    T     + +  V  V G
Sbjct: 30240 IQVRSVRVSWRPPAD------DGGADILGYILERREVPKAAWYTIDSRVRGTSLV--VKG 30291

Query: 861   LKKFTEYFTSVLCFTTPG-DGPRSTPQLVRTHEDVPGPVGHLSFSEILD---TSLKVSWQ 916
             LK+  EY   V      G   P  + + V     +  P    +  E+LD   +S+ +SW 
Sbjct: 30292 LKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWS 30351

Query: 917   EPGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLE-YRVTGLTALTTYTIEVAAMTSK 974
              P +  G  +TGY I  +E   T+  V H    +T   Y VTGL     Y   + A    
Sbjct: 30352 RPKDDGGSRVTGYYIERKE-TSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 30410

Query: 975   GQGQVSAST--ISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYD-GKTSISRWLVEA 1030
             G  + S ++  +    P + P  P  L I +I   SVTLQ+ +P  D GK  +  W+   
Sbjct: 30411 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 30470

Query: 1031  QVGVVGEGEEWLLIHQLSNEPDARSME--VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
             Q G       W    + SN+   +  +  +  L   T Y FR+   N  G S P + +  
Sbjct: 30471 QSG----DSAW----KKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMS 30522

Query: 1089  IQTL----QAP---PDMAPANVSLRTASETSLWLRWMPLPEME-YNGNPESVGYKIKYSR 1140
             I+T     +AP    +M      L  A++ S  +   PLP+++ Y    E +  +     
Sbjct: 30523 IKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMS 30582

Query: 1141  SDGHGKTLSHVVQDRVERDY-----TIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRT 1194
             SDG   TL+ + +++ +        T E  E  T  ++ +QA      G P  +   G  
Sbjct: 30583 SDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG-- 30640

Query: 1195  RESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKD---SDTQPRFW 1251
               +V S+   +V  +     +M   W             G K++   ++    +T+    
Sbjct: 30641 --AVGSTLRLHVMYIGRPVPAM--TWFH-----------GQKLLQNSENITIENTEHYTH 30685

Query: 1252  LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG-ILFP 1310
             LV  N  R    T  GKY +    V           +   IL+  + D P  P G I+  
Sbjct: 30686 LVMKNVQRK---THAGKYKVQLSNVFG---------TVDAILDVEIQDKPDKPTGPIVIE 30733

Query: 1311  EVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESV 1370
              +   S  + W+PPA   G  +   +  +          +   A S        L   + 
Sbjct: 30734 ALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAG 30793

Query: 1371  YLFRITAQTRKGWGEAAE--ALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSD 1427
             Y FR++AQ   G  +  E  ++V+     ++P  P +P +    V   S +++W+ P SD
Sbjct: 30794 YYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITA--VTKDSCVVAWKPPASD 30851

Query: 1428  GLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEF 1487
             G + +R Y ++ RE    +W +   +     + F V  L     Y+FRVK  N  G+SE+
Sbjct: 30852 GGAKIRNYYLEKREKKQNKW-ISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEW 30910

Query: 1488  SEESESLTTLQAAPDEAP 1505
             SE SE +T     P +AP
Sbjct: 30911 SEISEPITPKSDVPIQAP 30928



 Score =  155 bits (392), Expect = 4e-37
 Identities = 154/607 (25%), Positives = 250/607 (41%), Gaps = 52/607 (8%)

Query: 24   VSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS--- 80
            V P F T  ++    L G+ +V+ C   GS P+   W H   E++    +Y+  +T    
Sbjct: 7680 VPPSF-TRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISS-GRKYQTTLTDNTC 7737

Query: 81   ------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRA 134
                  L+ + +G Y CI  N  G+  +    + V    SF +      V  G      +
Sbjct: 7738 ALTVNMLEESDSGDYTCIATNMAGSD-ECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTS 7796

Query: 135  PRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNK 194
              +   P   V+WF+   ++ P  R  ++LE+++  L     D  +         N   K
Sbjct: 7797 I-VKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGK 7855

Query: 195  TSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKD 254
             S    L ++         AP   +   N   +     + LE      P I   + WKK+
Sbjct: 7856 ASCTTHLYIK---------APAKFVKRLNDYSIEKGKPLILEGTFTGTPPIS--VTWKKN 7904

Query: 255  GVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 308
            G+ ++         ++ +  L IP+ T  DAG Y C  +  +S   S    A + +LEPP
Sbjct: 7905 GINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCY-IENASGKDSC--SAQILILEPP 7961

Query: 309  QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQIS 368
             FVK+ E  +   +     + CQ  G P   ++WYK    +      +   RN+    + 
Sbjct: 7962 YFVKQLEP-VKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVF 8020

Query: 369  GLVP-DDTGMFQCFARNAAGEVQTSTYLAVTS--IAPNITRGPLDSTVIDGMSVVLACET 425
              V  +D+G + C A N+ GEV  ST+L V    + P+ +R   D     G+ VV  C  
Sbjct: 8021 NQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAI 8080

Query: 426  SGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
            SG+   +++W K G+ +  S +VQ        + +L I  T  S AG Y+C ATN  G  
Sbjct: 8081 SGSEPISVSWYKDGKPLKDSPNVQTSFLD--NTATLNIFKTDRSLAGQYSCTATNPIGSA 8138

Query: 485  EASADLVVWARTRITKPP------QDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL 538
             +SA L++   T    PP           + G  A   C VT    + +   W KD   +
Sbjct: 8139 SSSARLIL---TEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVS--WAKDSREI 8193

Query: 539  GTESHPRIR-LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPV 597
             +    +I  L+ +  L + +   GD G YTC  ++  G DS +A L +++    P    
Sbjct: 8194 RSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTK 8253

Query: 598  ATLSTVE 604
                TVE
Sbjct: 8254 RLSETVE 8260



 Score =  154 bits (390), Expect = 7e-37
 Identities = 325/1603 (20%), Positives = 591/1603 (36%), Gaps = 176/1603 (10%)

Query: 317   HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV-EVEKLTRFRQRNDGGLQISGLVPDDT 375
             ++ A  +  +D+P   KG P  ++ W KD   + E  ++     +    L I     +D 
Sbjct: 25405 NVKAREQLKIDVPF--KGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDV 25462

Query: 376   GMFQCFARNAAGEVQTS-TYLAVTSIAPNITRGPLDSTVIDGMSVVLA---------CET 425
             G ++    N+AG +    T + +    P    GP+    +   S+ ++         C+ 
Sbjct: 25463 GTYELCVSNSAGSITVPITIIVLDRPGPP---GPIRIDEVSCDSITISWNPPEYDGGCQI 25519

Query: 426   SG-----APRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480
             S          + TW    + +A  S+++ R T   +GS             +   A N 
Sbjct: 25520 SNYIVEKKETTSTTWHIVSQAVARTSIKIVRLT---TGSEY----------QFRVCAENR 25566

Query: 481   RGVDEASADLVVWARTRITKP--PQDQSVIKGTQASM--------------VCGVTHDPR 524
              G    S    V A    + P  P    V+  T+++M              V G   + +
Sbjct: 25567 YGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYK 25626

Query: 525   VTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAH- 583
                  +W K    L  ++  ++     G ++  + ++ +I           G  S+S   
Sbjct: 25627 ERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGI--------GKCSKSCEP 25678

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLAS 642
             +  R     P  P  T   + R++++L W+KP +DG + +  YI+E  E      +    
Sbjct: 25679 VPARDPCDPPGQPEVT--NITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNY 25736

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGK-GQFSKDTERVSLPEEPPTAPPQNVIASG 701
              + + T   V  L   + Y+FR+ A N      + S+ T  + + ++     P  V+   
Sbjct: 25737 TNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDD---VEPPRVMMDV 25793

Query: 702   RTNQSIMIQWQPPPESHQNGILKGY---IIRYCLAGLPVGYQFKN-ITDADVNNLL-LED 756
             +    I+++     +   N  + G    +I +   G+ +  + +  I   D + LL ++D
Sbjct: 25794 KFRDVIVVKAGEVLKI--NADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKD 25851

Query: 757   LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPS 816
              I     +  +   N AG     S      +   P  P G +      +     +W  P 
Sbjct: 25852 CIRRDTGQYVLTLKNVAGT---RSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQ 25908

Query: 817   PQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTT 876
                  G +  Y ++  E  +   +         Q +     V+ L K  EY   V     
Sbjct: 25909 ED--GGADIDYYIV--EKRETSHLAWTICEGELQMTSCK--VTKLLKGNEYIFRVTGVNK 25962

Query: 877   PGDGPRSTPQLVRTHED--VPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWE 933
              G G       ++  +   VP P   L  + +   S+ + W  P    G  ++GY I   
Sbjct: 25963 YGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERR 26022

Query: 934   EYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAST--ISSGVPPE 991
             E N       +  P   L  + TGL     Y   V A  + G    S ++  I +  P  
Sbjct: 26023 EKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVF 26082

Query: 992   LPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNE 1050
             LP PP+   I + G  ++T+ + +P +DG   I+ + VE +     +  +W    Q    
Sbjct: 26083 LPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKS---DDTDWKTSIQSLRG 26139

Query: 1051  PDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPS-------RKIQTL-QAPPDMAPAN 1102
              +     +  L     Y FR++ VN VG S PS  S       R+ + L     +M    
Sbjct: 26140 TE---YTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTL 26196

Query: 1103  VSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTI 1162
             +    AS T      M +P   + G P      + +S+ D   +T ++V         TI
Sbjct: 26197 IVKAGASFT------MTVP---FRGRPVP---NVLWSKPDTDLRTRAYVDTTDSRTSLTI 26244

Query: 1163  EDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSE 1222
             E+       +  +   N + +   S T+V +  ++     PTN++    T  S ++ W +
Sbjct: 26245 ENANRNDSGKYTLTIQNVLSAA--SLTLVVKVLDT--PGPPTNITVQDVTKESAVLSW-D 26299

Query: 1223  VPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSR-SAQLTGLGKYVLYEVQVLAFTR 1281
             VPE D    V  Y +   EK   ++  +  V  N +R S ++T L +  +Y  +V     
Sbjct: 26300 VPENDGGAPVKNYHI---EKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENE 26356

Query: 1282  IGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLN 1341
              G G P+      + + + P PP  +    +   SV L W  P    G  + + +   L 
Sbjct: 26357 FGVGIPAETKEGVK-ITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALE 26415

Query: 1342  TTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQ 1401
                 N   V+     +  +  +GL+  S Y FR+ A+ + G  +  E L+    K ++ +
Sbjct: 26416 KGQKNW--VKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIK-EQLE 26472

Query: 1402  PPSRPMVQQED----VRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHN 1457
             PP   M         VRA S L    P S    P+   T+    +P       +  ++  
Sbjct: 26473 PPEIDMKNFPSHTVYVRAGSNLKVDIPISG--KPLPKVTLSRDGVPLKATMRFNTEITAE 26530

Query: 1458  ASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTS 1517
               +  +       + ++ + A N  G ++       L   +  P   P ++S    T  S
Sbjct: 26531 NLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLD--RPGPPTGPVVISDI--TEES 26586

Query: 1518  VLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLS 1577
             V ++W+PP  D  + +                  + L       A W E+++  +   + 
Sbjct: 26587 VTLKWEPPKYDGGSQVT----------------NYILLKRETSTAVWTEVSATVARTMMK 26630

Query: 1578  RPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVV-VHGAT 1636
                LT  E         Y+ R+   N  G         V V     T  P +   V   T
Sbjct: 26631 VMKLTTGE--------EYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVT 26682

Query: 1637  ATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAY 1696
                + V W  P + +    + GY +   + +   L ++   L +     K+  ++    Y
Sbjct: 26683 RESITVGWHEP-VSNGGSAVVGYHLEMKD-RNSILWQKANKLVIRTTHFKVTTISAGLIY 26740

Query: 1697  MVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LE 1755
                V A NAAG G  S P++      A   P +V+ ++++  SV++SW+ P F  G  + 
Sbjct: 26741 EFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKIT 26800

Query: 1756  GYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK----TFTYGPE 1811
             GY  + E     DG  +         +     +  L +   Y FR+ A+    + +   E
Sbjct: 26801 GY--IVERRDLPDG--RWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSE 26856

Query: 1812  IEANVTTGPGEGAPG---PPGVPIIVRYSSAIAIHWSSGDPGK 1851
             +   +T     G P    P     +V+Y +  ++   +G  GK
Sbjct: 26857 VVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK 26899



 Score =  152 bits (385), Expect = 3e-36
 Identities = 144/585 (24%), Positives = 243/585 (41%), Gaps = 44/585 (7%)

Query: 22   DDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYM---- 77
            D + P   T+ ++    ++G+ + L C+  GS P+  +W  +++E++  S +Y++     
Sbjct: 4670 DLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISA-SEKYKFSFHDN 4728

Query: 78   -----ITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVI 132
                 I+ L+ T +G Y C   N+ G   Q    + V     F E  + Q V+      +
Sbjct: 4729 TAFLEISQLEGTDSGTYTCSATNKAGHN-QCSGHLTVKEPPYFVEKPQSQDVNPNTRVQL 4787

Query: 133  RAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENT---LVILSTVAPDAGRYYVQAVNDK 189
            +A    + P   + WF+D +++   +  ++  ++T   L + +  A D+G Y  Q  ND 
Sbjct: 4788 KALVGGTAPMT-IKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSNDV 4846

Query: 190  NGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHI 249
                  +   TL V+          P  I  P    V+      T EC     P  K+ +
Sbjct: 4847 G---TATSKATLFVKE--------PPQFIKKPSPVLVLRNGQSTTFECQITGTP--KIRV 4893

Query: 250  IWKKDG----VLLSGGIS--DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLS 303
             W  DG     +   GIS  D      I      ++G Y CEA   + +    +    L 
Sbjct: 4894 SWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIE---LK 4950

Query: 304  VLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR-ND 362
            V EPP F++E  + +       V++ C+  G PP  +TW K+   +   K      R + 
Sbjct: 4951 VKEPPTFIREL-KPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSV 5009

Query: 363  GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLA 422
              L I+   P DTG +QC   N  G    ST +A+    P+  +   ++T +   S    
Sbjct: 5010 FNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKE-PPSFIKKIENTTTVLKSSATFQ 5068

Query: 423  CETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRG 482
               +G+P  +ITW K ++IL         F      +L I       +G YTC A N  G
Sbjct: 5069 STVAGSPPISITWLKDDQILDEDDNVYISFVD-SVATLQIRSVDNGHSGRYTCQAKNESG 5127

Query: 483  VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTES 542
            V+   A L+V    +I +  +   V +    ++ C V   P + ++  W KDG  +    
Sbjct: 5128 VERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPELKVK--WLKDGKQIVPSR 5185

Query: 543  HPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRV 586
            +  +  + N  S  I      D G YT +V +  G+ S  A+LRV
Sbjct: 5186 YFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRV 5230



 Score =  149 bits (376), Expect = 3e-35
 Identities = 359/1701 (21%), Positives = 599/1701 (35%), Gaps = 236/1701 (13%)

Query: 305   LEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR---FRQ 359
             +EPP+ + + +    I  +  +V+ I     G P P I+W KD   +E+E+  R      
Sbjct: 25784 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDG--IEIEERARTEIIST 25841

Query: 360   RNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSV 419
              N   L +   +  DTG +    +N AG    +    V    P    GPL+   +     
Sbjct: 25842 DNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLD-KPGPPAGPLEINGLTAEKC 25900

Query: 420   VLAC----ETSGAPRPAITWQKGER-----ILASGSVQLP--RFTPLESGSLLISPTHIS 468
              L+     E  GA       +K E       +  G +Q+   + T L  G+  I      
Sbjct: 25901 SLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYI------ 25954

Query: 469   DAGTYTCLATNSRGVDEASADLVVWARTRIT--KPPQDQSVIKGTQASMVCGVTHDPRVT 526
                 +     N  GV E    + + A    T   PP    +   T+ SM           
Sbjct: 25955 ----FRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMT---------- 26000

Query: 527   IRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRV 586
                 W +  +  G+E    I ++R     +          Y  RV S G  +      RV
Sbjct: 26001 --LCWSRPESDGGSEISGYI-IERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRV 26057

Query: 587   RQ-----------------------LPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPL 622
                                      LP  P  P    S   +  I + W KP FDG +P+
Sbjct: 26058 YAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDS--GKTTITIAWVKPLFDGGAPI 26115

Query: 623   IRYILEMSE-NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681
               Y +E  + ++  W   + S+  + T  T+ GL     Y FR+ +VN VG    S  ++
Sbjct: 26116 TGYTVEYKKSDDTDWKTSIQSL--RGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSD 26173

Query: 682   RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILK---GYIIRYCLAGLPVG 738
                         PQ  IA  R  + +   +    E  +  I+K    + +     G PV 
Sbjct: 26174 ------------PQ--IAKEREEEPL---FDIDSEMRKTLIVKAGASFTMTVPFRGRPVP 26216

Query: 739   YQFKNITDADVNNLLLEDLI-IWTNYEIEVAAYNSAG------LGVYSSKVTEWTLQGVP 791
                 +  D D+      D     T+  IE A  N +G        V S+      ++ + 
Sbjct: 26217 NVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLD 26276

Query: 792   TV-PPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQ 850
             T  PP N+  +     +   +W+ P     N      K    E  +  +   V+   N  
Sbjct: 26277 TPGPPTNITVQDVTKESAVLSWDVPE----NDGGAPVKNYHIEKREASKKAWVSVTNNCN 26332

Query: 851   DSIHVGFVSGLKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFSEILDT 909
                +   V+ L++   Y+  V      G G P  T + V+  E  P P   L  + I   
Sbjct: 26333 RLSYK--VTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEK-PSPPEKLGVTSISKD 26389

Query: 910   SLKVSWQEPGEKNGI-LTGYRISWEEYNRTN------TRVTHYLPNVTLEYRVTGLTALT 962
             S+ ++W +P    G  +  Y +   E  + N       + TH++        V+GL   +
Sbjct: 26390 SVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--------VSGLRENS 26441

Query: 963   TYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTS 1022
              Y   V A    G        +   +  +L   P  + + N    S T+  R G + K  
Sbjct: 26442 EYFFRVFAENQAGLSDPRELLLPVLIKEQL--EPPEIDMKNF--PSHTVYVRAGSNLKVD 26497

Query: 1023  IS-RWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSP 1081
             I        +V +  +G       + + E  A ++ +      T  + R  ++    +S 
Sbjct: 26498 IPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRY-EITAANSSG 26556

Query: 1082  PSQPSRKIQTLQAP-PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGY-KIKYS 1139
              ++    I  L  P P   P  +S    +E S+ L+W P    +Y+G  +   Y  +K  
Sbjct: 26557 TTKAFINIVVLDRPGPPTGPVVIS--DITEESVTLKWEP---PKYDGGSQVTNYILLKRE 26611

Query: 1140  RSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVP 1199
              S      +S  V   + +   +  L    EY+ +++A N  G      +     +    
Sbjct: 26612 TSTAVWTEVSATVARTMMK---VMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYT 26668

Query: 1200  SSGPTNVSALA-TTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN-- 1256
             + GP +   +   T  S+ V W E P ++    V+GY +  K+++S      W       
Sbjct: 26669 TPGPPSTPWVTNVTRESITVGWHE-PVSNGGSAVVGYHLEMKDRNS----ILWQKANKLV 26723

Query: 1257  -SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP--PILERTLDDVPGPPMGILFPEVR 1313
               +   ++T +   ++YE +V A    G G PSHP  P+L     D   PP  +   ++ 
Sbjct: 26724 IRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVL---AIDACEPPRNVRITDIS 26780

Query: 1314  TTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLF 1373
               SV L WQ PA   G  +   I  R +              +  Q+  +GL   S Y F
Sbjct: 26781 KNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEF 26840

Query: 1374  RITAQTRKGWGEAAEALVVTTEKRDRPQPP--SRPMVQQEDVRARS-VLLSWEPGSDGL- 1429
             R+ A+   G       +V      D    P    P+   E V+ R+   +    G  G  
Sbjct: 26841 RVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKP 26900

Query: 1430  SPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE 1489
             +P   +    +EL +   AL     + + +S ++       S  + +K  N +G +  + 
Sbjct: 26901 APTIEWYKDDKELQTN--ALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATI 26958

Query: 1490  ESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGL 1549
               + L   +  P   P  +     T   + + W+PPA+D       G +I +        
Sbjct: 26959 RVQILD--KPGPPGGP--IEFKTVTAEKITLLWRPPADDG------GAKITH-------- 27000

Query: 1550  RGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGP 1609
               + +         W+ ++      +L    +T      + K   Y  R+   N  G G 
Sbjct: 27001 --YIVEKRETSRVVWSMVS-----EHLEECIIT---TTKIIKGNEYIFRVRAVNKYGIGE 27050

Query: 1610  SSPPQEVFVGEAVPTAAPRNV-VVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR 1668
                   V    A  T  P  +  V   T   + V W  P  D    DI G   YF E + 
Sbjct: 27051 PLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADG-GSDISG---YFLEKRD 27106

Query: 1669  GNLTERVKTL--FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQ---GQTQQAA 1723
                    K L   + +   K+  LT  + Y   V A NAAG GP S P++          
Sbjct: 27107 KKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDP 27166

Query: 1724  PSAPSSVKFSELTTTSVNVSWEAPQFPNG-ILEGYRLVYEPCSPVDGVSKIVTVDVKGN- 1781
             P  P+ ++ ++ T +S+ + W  P +  G  + GY +            +  TV  KG  
Sbjct: 27167 PGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEE----EEWTTVSTKGEV 27222

Query: 1782  SPLWLKVKDLAEGVTYRFR------------------IRAKTFTYGPEIEANVTTGPGEG 1823
                   V +L  GV Y FR                  ++AK     PEI+ +V       
Sbjct: 27223 RTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVI 27282

Query: 1824  APGPPGVPIIVRYSS--AIAIHWSSGDPGKGPITRYVIEARPS------------DEGLW 1869
             A     V +++ +       + W   +   G   RY IE   S            D G +
Sbjct: 27283 AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY 27342

Query: 1870  DILIKDIPKEVSSYTFSMDIL 1890
              + I++   E  S T S+ +L
Sbjct: 27343 ILTIENGVGEPKSSTVSVKVL 27363



 Score =  149 bits (376), Expect = 3e-35
 Identities = 360/1644 (21%), Positives = 594/1644 (36%), Gaps = 223/1644 (13%)

Query: 367   ISGLVPDDTGMFQCFARNAAG-----EVQTSTYLAVTSIAPNITRGPLDSTVID---GMS 418
             ++ L   +  +F+  A+N  G     E  T+  +    + P I    +    I    G  
Sbjct: 29696 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRP 29755

Query: 419   VVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
             V L    +G P PA +W   G ++  S  V +   T +    L I  T I D G YT   
Sbjct: 29756 VELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKV--AKLTIRETTIRDTGEYTLEL 29813

Query: 478   TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASM------------VCGVTHDPRV 525
              N  G    +  +++  +      P     I  T  ++            + G   + R 
Sbjct: 29814 KNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRD 29873

Query: 526   TIRYIW--EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
               R  W    +  T  T    R+         ++ T    IG+Y    + +   + RS+ 
Sbjct: 29874 AHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSY----LQSEVIECRSSI 29929

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLAS 642
                 ++P  PE     +  V R  + LTW  P D G S +  YI+E  E  A   V +  
Sbjct: 29930 ----RIPGPPE--TLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNK 29983

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTER-VSLPEEPPTAPPQNVIASG 701
             V    T     GL     Y+ R+ A+N  G G+ S+ ++  V++    P   PQN   + 
Sbjct: 29984 VPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTD 30043

Query: 702   RTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWT 761
              T  S+ + W  P E      + GY+I           +  N T   +    L  L    
Sbjct: 30044 TTRTSVSLAWSVP-EDEGGSKVTGYLIEMQKVDQHEWTKC-NTTPTKIREYTLTHLPQGA 30101

Query: 762   NYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFIN 821
              Y   V A N+ G              G P   PG V      +  + +       ++  
Sbjct: 30102 EYRFRVLACNAGG-------------PGEPAEVPGTVKV----TEMLEYPDYELDERYQE 30144

Query: 822   GI--NQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGD 879
             GI   QG  +    P + +   +       QD      ++  +  TE    V+     GD
Sbjct: 30145 GIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTEL---VIKEADRGD 30201

Query: 880   ------------GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LT 926
                         G ++    VR       P G L + +I   S++VSW+ P +  G  + 
Sbjct: 30202 SGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADIL 30261

Query: 927   GYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQV--SASTI 984
             GY +   E  +            T    V GL     Y   V+A    G  +   S   +
Sbjct: 30262 GYILERREVPKAAWYTIDSRVRGT-SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPV 30320

Query: 985   SSGVPPELPGPPTNLG-ISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWL 1042
             +   P   P PP+N   + ++   SV+L + RP  DG + ++ + +E +       ++W 
Sbjct: 30321 TPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETST---DKW- 30376

Query: 1043  LIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVG---TSPPSQPSRKIQTLQAPPDMA 1099
              +     +       V  L P   Y FR+   N VG   TSP S+P         P    
Sbjct: 30377 -VRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQ-- 30433

Query: 1100  PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV-ER 1158
             P  + + + S+ S+ L+W    + E +G  E +GY ++Y +S       S+  ++R+ ++
Sbjct: 30434 PGELEILSISKDSVTLQW---EKPECDGGKEILGYWVEYRQSGDSAWKKSN--KERIKDK 30488

Query: 1159  DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGP----------TNVSA 1208
              +TI  L E TEY  +V A N  G     +T +    +      P          T +  
Sbjct: 30489 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGE 30548

Query: 1209  LATTSSSMLVRWSEVPEADRNGLVLGYKVMYK-EKDSDTQPRFWLVEGNSSRSAQLTGLG 1267
              A  S  ++ R     +  R G  L     YK   D  T     + E            G
Sbjct: 30549 AAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE-------G 30601

Query: 1268  KYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRL----IWQP 1323
              Y       +A   +G+   S   +L+ T    PG P+   +     +++RL    I +P
Sbjct: 30602 VYTC-----IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRP 30656

Query: 1324  PAAPNGIILAYQITHRLNTTTANTAT-VEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382
               A         + +  N T  NT     ++  + ++ T  G        +++      G
Sbjct: 30657 VPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGK-------YKVQLSNVFG 30709

Query: 1383  WGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEP-GSDGLSPVRYYTIQTRE 1441
               +A    ++  E +D+P  P+ P+V  E +   S ++SW+P   DG S +  Y ++  E
Sbjct: 30710 TVDA----ILDVEIQDKPDKPTGPIVI-EALLKNSAVISWKPPADDGGSWITNYVVEKCE 30764

Query: 1442  LPSG-RWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA 1500
                G  W L S+++S      +   L     Y FRV A N  G S+  E S     +  +
Sbjct: 30765 AKEGAEWQLVSSAISVTTCRIV--NLTENAGYYFRVSAQNTFGISDPLEVSS--VVIIKS 30820

Query: 1501  PDE---APTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGI 1557
             P E   AP   ++T  T  S ++ W+PPA D       G +IR           + L   
Sbjct: 30821 PFEKPGAPGKPTITAVTKDSCVVAWKPPASDG------GAKIR----------NYYLEKR 30864

Query: 1558  NNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVF 1617
                   W  +T+            T + + NL +   YE R+   N  GE   S   E  
Sbjct: 30865 EKKQNKWISVTTEEIRE-------TVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPI 30917

Query: 1618  VGEA-VPTAAPR--------NVVVHGATATQLDVTWEPPPL------------DSQNGDI 1656
               ++ VP  AP         NV           VT  P P+            D     I
Sbjct: 30918 TPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRI 30977

Query: 1657  QGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQ 1716
             Q +K  + +    ++T+   T++    + +  +++G  +  V V A       P++    
Sbjct: 30978 QEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHL---PKTLEGM 31034

Query: 1717  GQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTV 1776
             G    A      S+K          ++W+  Q        Y+++         V++  T 
Sbjct: 31035 GAVH-ALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVI---------VTRSFTS 31084

Query: 1777  DVKGNSPLWLKVKDLAEGVTY---RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPII 1833
              V  N    ++ KD    V     RF I  KT      +E +V   P      P GV + 
Sbjct: 31085 LVFPNG---VERKDAGFYVVCAKNRFGIDQKT------VELDVADVPDP----PRGVKVS 31131

Query: 1834  VRYSSAIAIHWSS-GDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKP 1892
                  ++ + W+     G   IT Y++E   +    W  +      +     +++  L  
Sbjct: 31132 DVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRV-----GQARETRYTVINLFG 31186

Query: 1893  GVSYDFRVIAVNDYGFGTPSSPSQ 1916
               SY FRVIA N +G   PS PS+
Sbjct: 31187 KTSYQFRVIAENKFGLSKPSEPSE 31210



 Score =  147 bits (372), Expect = 8e-35
 Identities = 327/1497 (21%), Positives = 538/1497 (35%), Gaps = 177/1497 (11%)

Query: 361   NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
             ND G+    ++PD     +   R  A + +    L  T +            V  G+S+ 
Sbjct: 20752 NDAGVGEPAVIPD----VEIVEREMAPDFELDAELRRTLV------------VRAGLSIR 20795

Query: 421   LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT-HISDAGTYTCLATN 479
             +     G P P +TW K    L + +         ES +LLI P  +  D G +     N
Sbjct: 20796 IFVPIKGRPAPEVTWTKDNINLKNRA----NIENTESFTLLIIPECNRYDTGKFVMTIEN 20851

Query: 480   SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH--------DPRVTIRYIW 531
               G          +   R+   P     ++ T  +      H          R+T  YI 
Sbjct: 20852 PAGKKSG------FVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRIT-NYIV 20904

Query: 532   EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA-----GGNDSRSAHLRV 586
             EK  AT  + S    +  +        T   +   Y  RV++      G     +  ++ 
Sbjct: 20905 EKREATRKSYSTATTKCHK---CTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 20961

Query: 587   RQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASVDP 645
              + P  P+     +  + +  ++L W KP  DG S +  Y++E     +     + +V  
Sbjct: 20962 SEAPSPPDS--LNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV-- 21017

Query: 646   KATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT-----ERVSLPEEPPTAPPQN-VIA 699
             K     V+ L     Y F++ AVN  G+    +       E+  LPE       Q  VIA
Sbjct: 21018 KGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIA 21077

Query: 700   SGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLII 759
                 N  + I     P+          I++       V ++    T A    L + + + 
Sbjct: 21078 KAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQR---VNFE----TTATSTILNINECVR 21130

Query: 760   WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQF 819
               +    + A N  G       V    +  +P  P G +  +  +S  + F+W+ P    
Sbjct: 21131 SDSGPYPLTARNIVG---EVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPEND- 21186

Query: 820   INGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGD 879
               G+     ++  E  Q +  T V        + +    + L    EY   V      G 
Sbjct: 21187 -GGVPISNYVV--EMRQTDSTTWVELATTVIRTTYKA--TRLTTGLEYQFRVKAQNRYGV 21241

Query: 880   GPRSTPQLVRTHED--VPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYN 936
             GP  T   +  +    VPGP G    + +   S+ +SW EP    G  + GY +  +E N
Sbjct: 21242 GPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERN 21301

Query: 937   RTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA--MTSKGQGQVSASTISSGVPPELPG 994
                 +           ++ +GLT    Y   V A  M  K +    +  + +  P + PG
Sbjct: 21302 GILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPG 21361

Query: 995   PPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDA 1053
              P  L   NI   +VTL++ +P Y G   I+ ++VE +    G   +    + L NE   
Sbjct: 21362 KPVPL---NITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENE--- 21415

Query: 1054  RSMEVPDLNPFTCYSFRMRQVNIVGT-SPPSQPSRKI---QTLQAPP---DMAPANVSLR 1106
                 V  L     Y FR+   N  G  SPPS+PS  I     ++AP    D+   +  + 
Sbjct: 21416 --FTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVIL 21473

Query: 1107  TASET---SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIE 1163
              A E       +   P P ME++ + + +    K          ++    + V +D T  
Sbjct: 21474 KAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIK------IADFSTNLVNKDSTRR 21527

Query: 1164  DLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEV 1223
             D   +T     + A N  G       V    R   P  GP  V+ +  TS   ++ W   
Sbjct: 21528 DSGAYT-----LTATNPGGFAKHIFNVKVLDRPG-PPEGPLAVTEV--TSEKCVLSW--F 21577

Query: 1224  PEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQL--TGLGKYVLYEVQVLAFTR 1281
             P  D  G  + + ++ K    +T    W    +  +  +L  T L K   Y  +V+A  +
Sbjct: 21578 PPLDDGGAKIDHYIVQKR---ETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNK 21634

Query: 1282  IGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRL 1340
              G G P    P+L       P PP       +   S+ + W  P +  G  +   I  R 
Sbjct: 21635 YGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERR 21694

Query: 1341  NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG--EAAEALVVTTEKRD 1398
             +              +  +Y  +GL     Y FRI A+   G              +   
Sbjct: 21695 DKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVF 21754

Query: 1399  RPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHN 1457
             +P PP  P V   D    S+ ++W +P  DG S +  Y ++        W + +      
Sbjct: 21755 KPGPPGNPRVL--DTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLK 21812

Query: 1458  ASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTS 1517
             A+S+ +  L     YK R+ A N  G  E                  P ++  TP     
Sbjct: 21813 ATSYTITGLTENQEYKIRIYAMNSEGLGE------------------PALVPGTPKAEDR 21854

Query: 1518  VLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFT-LRGINNPGATWAELTSMYSMRNL 1576
             +L     P E +++  L    +  R      LR F  ++G   P   WA      S+   
Sbjct: 21855 ML-----PPEIELDADLRKV-VTIRACC--TLRLFVPIKGRPAPEVKWAR-DHGESLDKA 21905

Query: 1577  SRPSLTQYEL---DNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV--PTAAPRNVV 1631
             S  S + Y L    N+N+    +  ++V N      SS  +  FV   V      P+++ 
Sbjct: 21906 SIESTSSYTLLIVGNVNRFDSGKYILTVEN------SSGSKSAFVNVRVLDTPGPPQDLK 21959

Query: 1632  VHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLA---ENSVKLK 1688
             V   T T + +TW+PP LD       G KI  +  ++   T +  +       + S K+ 
Sbjct: 21960 VKEVTKTSVTLTWDPPLLDG------GSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVD 22013

Query: 1689  NLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQ 1748
              L    +Y   V A N  G G  +   +       P  P  +   ++T  SV++SWE P+
Sbjct: 22014 QLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPE 22073

Query: 1749  FPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK 1804
                G  + GY +V       D  +   TV V   +     +  L +G  Y FR+ A+
Sbjct: 22074 HDGGSRILGY-IVEMQTKGSDKWATCATVKVTEAT-----ITGLIQGEEYSFRVSAQ 22124



 Score =  143 bits (361), Expect = 2e-33
 Identities = 145/585 (24%), Positives = 238/585 (40%), Gaps = 50/585 (8%)

Query: 31   EPVRTQVHLEGNRLV-------LTCMAEGSWPLEFKWLHNNREL---TKFSLEYRYMITS 80
            EP R    LE +R+V         C   GS  ++  W  +  E+   +KF + +   +  
Sbjct: 7303 EPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAV 7362

Query: 81   LDRTH-----AGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAP 135
            L+  +     +G Y C   N  G+     T ++V     F + + H   +   A V    
Sbjct: 7363 LEMHNLSVEDSGDYTCEAHNAAGSA-SSSTSLKVKEPPIFRK-KPHPIETLKGADVHLEC 7420

Query: 136  RIASFPQPQVTWFRDGRKIPPSSRIAITLENTLV---ILSTVAPDAGRYYVQAVNDKNGD 192
             +   P   V+W++D R++    +  I  EN L    IL+  A D G Y  +A ND   D
Sbjct: 7421 ELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSD 7480

Query: 193  NKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLI------K 246
                         VG  A    P  +    + S V G        +  A P+       K
Sbjct: 7481 TC-----------VGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDK 7529

Query: 247  LHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE 306
              I+ + D + +S   S++   L       ++AG Y C+ +   + +      A LSVLE
Sbjct: 7530 GEIVRESDNIWIS--YSENIATLQFSRVEPANAGKYTCQ-IKNDAGMQECF--ATLSVLE 7584

Query: 307  PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND-GGL 365
            P   V++PE  I         + C   G P  S  W+KD   +  +   +    N   GL
Sbjct: 7585 PATIVEKPES-IKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGL 7643

Query: 366  QISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT--SIAPNITRGPLDSTVIDGMSVVLAC 423
            +I  + P D+G++    +N  G+   +  L V+  ++ P+ TR   ++  + G SVV+ C
Sbjct: 7644 KIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMEC 7703

Query: 424  ETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGV 483
            +  G+P  +++W      ++SG       T   + +L ++    SD+G YTC+ATN  G 
Sbjct: 7704 KVYGSPPISVSWFHEGNEISSGRKYQTTLTD-NTCALTVNMLEESDSGDYTCIATNMAGS 7762

Query: 484  DEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESH 543
            DE SA L V       + P    V+ GT  +    V   P  ++   W K  + L     
Sbjct: 7763 DECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVS--WFKGSSELVPGDR 7820

Query: 544  PRIRL-DRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVR 587
              + L D    L +    +   G YTC V +  G  S + HL ++
Sbjct: 7821 CNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKASCTTHLYIK 7865



 Score =  142 bits (359), Expect = 3e-33
 Identities = 154/583 (26%), Positives = 222/583 (38%), Gaps = 65/583 (11%)

Query: 41   GNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMIT-----------SLDRTHAGFY 89
            G   +L C   GS P+   W H   E TK     +Y  T           SLD +  G Y
Sbjct: 5814 GASCILECKVAGSSPISVAWFH---EKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNY 5870

Query: 90   RCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFR 149
             C+  N  G+   R   + V    SF +  +   V  G+     +  I   P  +V WFR
Sbjct: 5871 TCVAANVAGSDECRAV-LTVQEPPSFVKEPEPLEVLPGKNVTFTSV-IRGTPPFKVNWFR 5928

Query: 150  DGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGP 209
              R++    R  I  E+T+  L                  N D   S   T  V N  G 
Sbjct: 5929 GARELVKGDRCNIYFEDTVAELELF---------------NIDISQSGEYTCVVSNNAGQ 5973

Query: 210  ADPIAPTIIIPP-------KNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGG- 261
            A       +  P        + SV  G S +         P+    + WKKDG  ++   
Sbjct: 5974 ASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPI---SVTWKKDGFNITTSE 6030

Query: 262  -----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPER 316
                  ++    L I N T  DAG Y CE     +     V GA +S LEPP FV E E 
Sbjct: 6031 KCNIVTTEKTCILEILNSTKRDAGQYSCEI---ENEAGRDVCGALVSTLEPPYFVTELE- 6086

Query: 317  HITAEMEKVVDIPCQAKGVPPPSITWYK-DAAVVEVEKLTRFRQRNDGGLQISGLVPDDT 375
             + A +   V + CQ  G P  +++WYK D  +    +   +   N   L  + +  +D+
Sbjct: 6087 PLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDS 6146

Query: 376  GMFQCFARNAAGEVQTSTYLAV--TSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
            G + C A N+ G   + T   +    + P+  R   D     G+ V L C  +G+    +
Sbjct: 6147 GEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQV 6206

Query: 434  TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 493
             W + + +L      L         +L I  T +S +G Y+C A+N  G   +SA L   
Sbjct: 6207 CWYR-DGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLT-- 6263

Query: 494  ARTRITKP-----PQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIR- 547
            AR     P     P    VI G  A   C VT      +R  W KD   +    +  I  
Sbjct: 6264 AREPKKSPFFDIKPVSIDVIAGESADFECHVT--GAQPMRITWSKDNKEIRPGGNYTITC 6321

Query: 548  LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLP 590
            +     L I +   GD G YTC+  +  G D  SA L V++ P
Sbjct: 6322 VGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVKEPP 6364



 Score =  142 bits (358), Expect = 4e-33
 Identities = 142/602 (23%), Positives = 256/602 (42%), Gaps = 41/602 (6%)

Query: 41   GNRLVLTCMAEGSWPLEFKWLHNNRELTKFS----LEYRYMITSL-----DRTHAGFYRC 91
            G  + L    EG+ P+   W  +  E+ + S    + Y   I +L     +  +AG Y C
Sbjct: 7506 GKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTC 7565

Query: 92   IVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDG 151
             ++N  G + +    + V    +  E  +   V+ G+   +    +A  P+    WF+DG
Sbjct: 7566 QIKNDAG-MQECFATLSVLEPATIVEKPESIKVTTGDTCTLECT-VAGTPELSTKWFKDG 7623

Query: 152  RKIPPSSRIAITLENT---LVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGG 208
            +++   ++  I+  N    L I++    D+G Y  +  N    D+ T+   +L V +   
Sbjct: 7624 KELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTA---SLQVSDRTV 7680

Query: 209  PADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGG------I 262
            P     P+     K T+ ++G+S V +EC     P I   + W  +G  +S G      +
Sbjct: 7681 P-----PSFTRKLKETNGLSGSS-VVMECKVYGSPPIS--VSWFHEGNEISSGRKYQTTL 7732

Query: 263  SDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEM 322
            +D+   LT+     SD+G Y C A   + S       A L+V EPP FV++P+       
Sbjct: 7733 TDNTCALTVNMLEESDSGDYTCIATNMAGSDEC---SAPLTVREPPSFVQKPDPMDVLTG 7789

Query: 323  EKVVDIPCQAKGVPPPSITWYKDAA-VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCF 381
              V       KG PP S++W+K ++ +V  ++     + +   L++  +    +G + C 
Sbjct: 7790 TNVT-FTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848

Query: 382  ARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERI 441
              N AG+   +T+L + + A  + R   D ++  G  ++L    +G P  ++TW+K   I
Sbjct: 7849 VSNEAGKASCTTHLYIKAPAKFVKRLN-DYSIEKGKPLILEGTFTGTPPISVTWKKNG-I 7906

Query: 442  LASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKP 501
              + S +    T  +S  L I  + + DAG Y C   N+ G D  SA +++       K 
Sbjct: 7907 NVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQ 7966

Query: 502  PQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQTW 560
             +   V  G  AS+ C +   P + +   W K    L   +  ++    N  +L  +Q  
Sbjct: 7967 LEPVKVSVGDSASLQCQLAGTPEIGVS--WYKGDTKLRPTTTYKMHFRNNVATLVFNQVD 8024

Query: 561  SGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNS 620
              D G Y C+  ++ G  S S  L V++    P          E   + + +     G+ 
Sbjct: 8025 INDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSE 8084

Query: 621  PL 622
            P+
Sbjct: 8085 PI 8086



 Score =  142 bits (357), Expect = 5e-33
 Identities = 172/697 (24%), Positives = 274/697 (39%), Gaps = 62/697 (8%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTK---FSLEYRYMITSL- 81
            PYF  EP+     + G    L C  +G+  +   W   + +L     + ++++  + SL 
Sbjct: 7020 PYF-IEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLV 7078

Query: 82   ----DRTHAGFYRCIVRNRMGALLQRQTEVQVAYM--GSFEEGEKHQSVSHGEAAVIRAP 135
                D +  G Y C   N +GA+      V  A      F    K    + G        
Sbjct: 7079 INKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFEC- 7137

Query: 136  RIASFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDKNGD 192
            RI      QV+W++DG  +   + +  +  +   TL IL T     G+Y   A N   G 
Sbjct: 7138 RINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPL-GT 7196

Query: 193  NKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWK 252
              +S  + L+   V        P   + P +  +  G S  T +C       IK  I W 
Sbjct: 7197 ASSSAKLILSEHEV-------PPFFDLKPVSVDLALGESG-TFKCHVTGTAPIK--ITWA 7246

Query: 253  KDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE 306
            KD   +  G      + ++   LT+      DAG Y C A   S+        A L V E
Sbjct: 7247 KDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYA---SNIAGKDSCSAQLGVQE 7303

Query: 307  PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDG 363
            PP+F+K+ E     + ++     C+  G P   + WYKD    E+++ ++FR     +  
Sbjct: 7304 PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDE--TEIQESSKFRMSFVDSVA 7361

Query: 364  GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLAC 423
             L++  L  +D+G + C A NAAG   +ST L V    P   + P     + G  V L C
Sbjct: 7362 VLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKE-PPIFRKKPHPIETLKGADVHLEC 7420

Query: 424  ETSGAPRPAITWQKGERILASG---SVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480
            E  G P   ++W K +R L SG    +    F      S+ I     +D G Y C ATN 
Sbjct: 7421 ELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLT----SIHILNVDAADIGEYQCKATND 7476

Query: 481  RGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540
             G D     + + A  R  K   D S + G +  +    T +    I  +W KD   +  
Sbjct: 7477 VGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQL--QTTIEGAEPISVVWFKDKGEIVR 7534

Query: 541  ES-HPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVA 598
            ES +  I    N  +L  S+    + G YTC++ +  G     A L V +     E P +
Sbjct: 7535 ESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIVEKPES 7594

Query: 599  -TLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVP 657
              ++T +   +  T     + ++   +   E++ +N        S   K + + +  + P
Sbjct: 7595 IKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNK----YKISFFNKVSGLKIINVAP 7650

Query: 658  ARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPP 694
            + S  +     N VG     KD+   SL     T PP
Sbjct: 7651 SDSGVYSFEVQNPVG-----KDSCTASLQVSDRTVPP 7682



 Score =  142 bits (357), Expect = 5e-33
 Identities = 357/1681 (21%), Positives = 598/1681 (35%), Gaps = 218/1681 (12%)

Query: 289   RSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAV 348
             RS +VP V +     V+EP   VK      + ++ + + I     G P P+ITW KD   
Sbjct: 23215 RSLAVPIVAKDL---VIEPD--VKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDG-- 23267

Query: 349   VEVEKLTRFRQRND---GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT 405
             + +++ TR    +      L I     DD G +     N  G+ +T++   VT   P+  
Sbjct: 23268 LPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQ-KTASIEIVTLDKPDPP 23326

Query: 406   RGPLDSTVIDGMSVVLACE----TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461
             +GP+    +   S+ L+      T G        QK +       V       +   +L 
Sbjct: 23327 KGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVV---SATVARTTLK 23383

Query: 462   ISPTHISDAGTYTCLATNSRGVDEA--SADLVVWARTRITKPP---------QDQSVIK- 509
             ++         +   A N  G   A  S  +V     +   PP         +D  VI+ 
Sbjct: 23384 VTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQW 23443

Query: 510   ----GTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIG 565
                     S V G   + +     +W K   T+  ++  + +       ++ +    +  
Sbjct: 23444 HEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQ-------NLEEGIEYEFR 23496

Query: 566   TYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIR 624
              Y   ++  G     S     R     P  P   +  V+R  I L WTKP +DG S +  
Sbjct: 23497 VYAENIVGVGKASKNSECYVARDPCDPPGTPEPIM--VKRNEITLQWTKPVYDGGSMITG 23554

Query: 625   YILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT---- 680
             YI+E  +      +  +  +   T  TV GL   + Y+FR+ A N  G      D+    
Sbjct: 23555 YIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPI 23614

Query: 681   ---ERVSLP--EEPPTAPPQNVIASGRT-NQSIMIQWQPPPESHQNGILKGYIIRYCLAG 734
                + V LP     P      V+ +G T      +  +P P                +  
Sbjct: 23615 TAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP---------------TIEW 23659

Query: 735   LPVGYQFKNITDADVNN------LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQ 788
             L    + +     ++ N      L+++D I     +  + A N AG   +   V    + 
Sbjct: 23660 LRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNV---KVL 23716

Query: 789   GVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPN 848
               P  P G V      S     TW   SP   +G +     +  + E       V A   
Sbjct: 23717 DRPGPPEGPVQVTGVTSEKCSLTW---SPPLQDGGSDISHYVVEKRETSRLAWTVVASEV 23773

Query: 849   FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGP--RSTPQLVRTHEDVPGPVGHLSFSEI 906
               +S+    V+ L +  EY   ++     G G    S P L++    +PGP   L  + I
Sbjct: 23774 VTNSLK---VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNI 23830

Query: 907   LDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTR-VTHYLPNVT-LEYRVTGLTALTT 963
                S+ V W  P    G  + GY +  E+ +R+  R +      +T L  RVTGLT    
Sbjct: 23831 AKDSMTVCWNRPDSDGGSEIIGYIV--EKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHE 23888

Query: 964   YTIEVAAMTSKGQGQVSASTI--SSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGK 1020
             Y   V+A  + G G+ S +T+   +  P   PGPPTN  I +    S+TL + +P YDG 
Sbjct: 23889 YEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGG 23948

Query: 1021  TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVG-- 1078
             + I  ++VE       + EEW ++   +     R  E+  L     Y  R+  +N VG  
Sbjct: 23949 SEILGYVVEI---CKADEEEWQIVTPQTGLRVTR-FEISKLTEHQEYKIRVCALNKVGLG 24004

Query: 1079  --TSPPS--QPSRKIQTLQAPPDM-APANVSLRTASETSLWLRWMPLPEMEYNGNPESVG 1133
               TS P   +P  K++  +   D      + +R      +         + + G P    
Sbjct: 24005 EATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARI--------HIPFKGRPTP-- 24054

Query: 1134  YKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGR 1193
              +I +SR +G       + +       +I++ +     +  ++  N+ GS     TV   
Sbjct: 24055 -EITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTV--- 24110

Query: 1194  TRESVPSSG-PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWL 1252
               + + + G P N++       S  + W E P  D    V  Y +   +K   T+  +  
Sbjct: 24111 --KVLDTPGPPQNLAVKEVRKDSAFLVW-EPPIIDGGAKVKNYVI---DKRESTRKAYAN 24164

Query: 1253  VEGNSSR-SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPE 1311
             V    S+ S ++  L +  +Y  +V+A    G G P       +  +  P PP  +   +
Sbjct: 24165 VSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEP-PSPPGKVTLTD 24223

Query: 1312  VRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESV 1370
             V  TS  L+W+ P    G  +L Y +  +   T   +   E    +A     TGL     
Sbjct: 24224 VSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNA---VVTGLSSGQE 24280

Query: 1371  YLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVL----------- 1419
             Y FR+ A   KG  +     V    K    QP  +       ++A   L           
Sbjct: 24281 YQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR 24340

Query: 1420  --LSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVK 1477
               +SW    DG  P++  T    E  +    LH      N   F           K+ V 
Sbjct: 24341 PNISWV--KDG-EPLKQTTRVNVEETATSTVLHIK--EGNKDDF----------GKYTVT 24385

Query: 1478  ATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGF 1537
             ATN  G +  +E    +   +  P   P        +   V+I W+PPA           
Sbjct: 24386 ATNSAGTA--TENLSVIVLEKPGPPVGPVRFDEV--SADFVVISWEPPA----------- 24430

Query: 1538  RIRYRELLYEG---LRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRR 1594
                     Y G   +  + +   +    TW  +++  +         T  ++  L     
Sbjct: 24431 --------YTGGCQISNYIVEKRDTTTTTWHMVSATVAR--------TTIKITKLKTGTE 24474

Query: 1595  YEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNV-VVHGATATQLDVTWEPPPLDSQN 1653
             Y+ R+   N  G+      + V V        P     V   +  Q+ V W  P  D   
Sbjct: 24475 YQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDG-G 24533

Query: 1654  GDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRST 1713
               I GY +   E +   L  ++    + +   K   L     Y   V+A N  G G  S 
Sbjct: 24534 TKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSK 24592

Query: 1714  PTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSK 1772
              ++    +     P   +   +T  +V + W+ P +  G  + GY  + E     DG  +
Sbjct: 24593 VSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGY--IVEKKDLPDG--R 24648

Query: 1773  IVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK----TFTYGPEIEANVTTGPGEGAPGPP 1828
              +             V  L E   Y FR+ A+     F+   +    +T      AP   
Sbjct: 24649 WMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNAS 24708

Query: 1829  GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMD 1888
               P   +Y   I +H  +G+        +V+EA    + + D++     KE+      M+
Sbjct: 24709 LDP---KYKDVIVVH--AGE-------TFVLEADIRGKPIPDVVWSKDGKELEETAARME 24756

Query: 1889  I 1889
             I
Sbjct: 24757 I 24757



 Score =  139 bits (350), Expect = 3e-32
 Identities = 336/1554 (21%), Positives = 565/1554 (36%), Gaps = 218/1554 (14%)

Query: 378   FQCFARNAAGEVQ---TSTYLAVTSIAPN----ITRGPLDSTVID-GMSVVLACETSGAP 429
             F+  A N AGE +   T+  +  T I       I  G  D  V   G  + +     G P
Sbjct: 15779 FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 15838

Query: 430   RPAITWQ---KGERILASGSVQLPRFTPLE----SGSLLISPTHISDAGTYTCLATNSRG 482
              P  +W+   K ++ +  G   +P    LE    S  ++I     S  G Y+  A N  G
Sbjct: 15839 TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 15898

Query: 483   VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVT-----HDPRVTIR-YIWEKDGA 536
                A+  + V     +  PP+D  V   T+ S  C ++      D    I+ Y+ EK   
Sbjct: 15899 QKTANCRVKVMD---VPGPPKDLKVSDITRGS--CRLSWKMPDDDGGDRIKGYVIEK--R 15951

Query: 537   TLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRV-----ISAGGNDSRSAHLRVRQLPH 591
             T+  ++  ++  D   +  +      +   Y  RV        G           R   +
Sbjct: 15952 TIDGKAWTKVNPDCGSTTFVVPDLLSE-QQYFFRVRAENRFGIGPPVETIQRTTARDPIY 16010

Query: 592   APEHPVAT-LSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLA-----SVD 644
              P+ P+   +  + +  ++L+W  P  DG SP+  YI+E    +   T   A       D
Sbjct: 16011 PPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRD 16070

Query: 645   PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSK-----DTERVSLPE--------EPPT 691
              +    TV+ LV    Y+FR+ AVN  G  + S      D +R  +P         E   
Sbjct: 16071 VEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEE 16130

Query: 692   APPQNVIASGRTNQSIMIQW-QPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVN 750
                 N++A  +      + W + PP+   N               PV Y      D  VN
Sbjct: 16131 GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKE-------------PVLY------DTHVN 16171

Query: 751   NLLLED---LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQ--GVPTVPPGNVHAEATNS 805
              L+++D   L+I  +   +   Y    +    +   E  L   G P  P G +  E+ ++
Sbjct: 16172 KLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSA 16231

Query: 806   TTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFT 865
               +  +W  P        + G K+  +  E+ E         + +       +  L +  
Sbjct: 16232 DQMTLSWFPPKD------DGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGH 16285

Query: 866   EYFTSVLCFTTPGDGPR--STPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG 923
             EY   ++     G G    S P+  R    VPG     + S +   S+ V+W+EP    G
Sbjct: 16286 EYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGG 16345

Query: 924   I-LTGYRIS--------WEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSK 974
               +TGY +         W+  NR   +       + + Y+VTGL   + Y   V A+ + 
Sbjct: 16346 SPVTGYWLEMKDTTSKRWKRVNRDPIKAM----TLGVSYKVTGLIEGSDYQFRVYAINAA 16401

Query: 975   GQGQVS--ASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQ 1031
             G G  S  +   ++  P   PGPP    +++    S  L++ P   DG + ++ ++VE +
Sbjct: 16402 GVGPASLPSDPATARDPIAPPGPPFP-KVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYK 16460

Query: 1032  VGVVGEG-EEWLLIHQLSNEPDAR--SMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
                  EG EEW    +   + + R   + V  L     Y FR+R VNI G   P + +  
Sbjct: 16461 ----EEGKEEW----EKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDV 16512

Query: 1089  IQ---TLQAPPDMAPANVSLRTASETS------LWLRWMPLPEMEYNGNPESVGYKIKYS 1139
             I+    L +P     A+V  R             ++   P P + +N N  ++  +    
Sbjct: 16513 IEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQE---- 16568

Query: 1140  RSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVP 1199
                      + +    +     I++ +   +    + A N   +G   +T++    + VP
Sbjct: 16569 ---------ATIETTAISSSMVIKNCQRSHQGVYSLLAKNE--AGERKKTIIVDVLD-VP 16616

Query: 1200  SSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW--LVEGNS 1257
                 T   A   T+ S  + W   PE D    +  Y +  +E D     R W  +    +
Sbjct: 16617 GPVGTPFLAHNLTNESCKLTWFS-PEDDGGSPITNYVIEKRESDR----RAWTPVTYTVT 16671

Query: 1258  SRSAQLTGLGKYVLYEVQVLAFTRIGDGS--PSHPPILERTLDDVPGPPMGILFPEVRTT 1315
              ++A + GL +   Y  ++ A   IG G    +   ++ R    VP  P  +   EV   
Sbjct: 16672 RQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKN 16731

Query: 1316  SVRLIWQPPAAPNGI-ILAYQITHRL-NTTTANTATVEVLAPSARQYTATGLKPESVYLF 1373
             +V L W PP    G  I+ Y +  RL  T   +  T + L   +R+YT  GLK    Y +
Sbjct: 16732 TVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLL--SRKYTVKGLKEGDTYEY 16789

Query: 1374  RITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR 1433
             R++A    G G+ +      T K D   PP+  +    D R +   L+   G       R
Sbjct: 16790 RVSAVNIVGQGKPSFCTKPITCK-DELAPPTLHL----DFRDK---LTIRVGEAFALTGR 16841

Query: 1434  YYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATND------IGDSEF 1487
             Y     +  P   W    A V  +  + I          K + K ++       + +S  
Sbjct: 16842 Y---SGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTG 16898

Query: 1488  SEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYE 1547
             S +      +   P      +S    T   ++I W+PP +D     +  + I  +E+  +
Sbjct: 16899 SRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDG-GSKITNYIIEKKEVGKD 16957

Query: 1548  GLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGE 1607
                             W  +T        S  + T  ++  L + + Y  R+   N  G 
Sbjct: 16958 ---------------VWMPVT--------SASAKTTCKVSKLLEGKDYIFRIHAENLYGI 16994

Query: 1608  GPSSPPQEVFVGE--AVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWE 1665
                     +   +   VP  AP   +V   T     VTW  P        I  Y +   E
Sbjct: 16995 SDPLVSDSMKAKDRFRVPD-APDQPIVTEVTKDSALVTWNKP--HDGGKPITNYILEKRE 17051

Query: 1666  AQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDG---PRSTPTQGQTQQA 1722
                       K         ++ +L     Y   V+A N  G G   P S P   +   A
Sbjct: 17052 TMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIA 17111

Query: 1723  APSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGN 1781
              PS P + +  + T  SV+++W+ P+   G  + GY + Y+     D   +      +  
Sbjct: 17112 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVG--DEEWRRANHTPESC 17169

Query: 1782  SPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
                  KV  L +G TY+FR+ A                 GE  P     P++V+
Sbjct: 17170 PETKYKVTGLRDGQTYKFRVLA-------------VNAAGESDPAHVPEPVLVK 17210



 Score =  138 bits (347), Expect = 7e-32
 Identities = 278/1273 (21%), Positives = 477/1273 (37%), Gaps = 148/1273 (11%)

Query: 693   PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNI-TDADVNN 751
             PPQ++     T  S+ + W PP     + I K YI+    +       +  + T+    +
Sbjct: 21954 PPQDLKVKEVTKTSVTLTWDPPLLDGGSKI-KNYIVEKRESTRKA---YSTVATNCHKTS 22009

Query: 752   LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 811
               ++ L    +Y   V A N  G+G+  ++  E        +PPG +        ++  +
Sbjct: 22010 WKVDQLQEGCSYYFRVLAENEYGIGL-PAETAESVKASERPLPPGKITLMDVTRNSVSLS 22068

Query: 812   WNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSV 871
             W  P     + I  GY +       ++  T  T +      +    ++GL +  EY   V
Sbjct: 22069 WEKPEHDGGSRI-LGYIVEMQTKGSDKWATCATVK------VTEATITGLIQGEEYSFRV 22121

Query: 872   LCFTTPG-DGPRSTPQLVRTHEDVPGPVGHL---SFSEILDTSLKVSWQEPGEKNGILTG 927
                   G   PR     V   + V  P   L   +F+ +    LKV     G     +T 
Sbjct: 22122 SAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTW 22181

Query: 928   YR--ISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
             ++  +  ++  R N   T    N  L  +      +  Y +++    S G+   + + I 
Sbjct: 22182 HKDNVPLKQTTRVNAESTEN--NSLLTIKDACREDVGHYVVKLT--NSAGEAIETLNVIV 22237

Query: 986   SGVPPELPGPPTN-LGISNIGPRSVTLQFRPG-YDGKTSISRWLVEAQVGVVGEGEEWLL 1043
                  + PGPPT  + +  +   S+TL + P  YDG +SI+ ++VE +       +    
Sbjct: 22238 L----DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKR-------DTSTT 22286

Query: 1044  IHQLSNEPDARS-MEVPDLNPFTCYSFRMRQVNIVGTSP--PSQPSRKIQTLQAPPDMAP 1100
               Q+ +   AR+ ++   L     Y FR+   N  G S    S+P+      + P     
Sbjct: 22287 TWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGT 22346

Query: 1101  ANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV---E 1157
               V+L  +S  S+ ++W    E   +G    +GY ++    +    ++  V  ++    +
Sbjct: 22347 PVVTL--SSRDSMEVQWN---EPISDGGSRVIGYHLERKERN----SILWVKLNKTPIPQ 22397

Query: 1158  RDYTIEDLEEWTEYRVQVQAFNAIGSGP---WSQTVVGRTRESVPSSGPTNVSALATTSS 1214
               +    LEE  EY  +V A N +G G     S+  V R     P   P    A+  T +
Sbjct: 22398 TKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARD----PCDPPGRPEAIIVTRN 22453

Query: 1215  SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA---------QLTG 1265
             S+ ++W + P  D    + GY V  KE          L EG   +++         ++TG
Sbjct: 22454 SVTLQWKK-PTYDGGSKITGYIVEKKE----------LPEGRWMKASFTNIIDTHFEVTG 22502

Query: 1266  LGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI---WQ 1322
             L +   YE +V+A    G  S         T  D   PP   + P+ + T V      ++
Sbjct: 22503 LVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFK 22562

Query: 1323  PPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382
               A   G  +      + +   +NTA +E+ +       AT L  +            K 
Sbjct: 22563 VDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDF----ATSLSVKDAVRVDSGNYILKA 22618

Query: 1383  WGEAAE-ALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTR 1440
                A E ++ V  +  DRP PP  P+V    V A    L+W+P   DG S +  Y ++ R
Sbjct: 22619 KNVAGERSVTVNVKVLDRPGPPEGPVVIS-GVTAEKCTLAWKPPLQDGGSDIINYIVERR 22677

Query: 1441  ELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA 1500
             E     W +  A+V     S  V +L     Y FR+ A N  G  E  E    +      
Sbjct: 22678 ETSRLVWTVVDANVQ--TLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFV 22735

Query: 1501  PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNP 1560
               +AP    VT  T  S+++ W+ PA D  + IL                G+ L   +  
Sbjct: 22736 VPDAPKAPEVTTVTKDSMIVVWERPASDGGSEIL----------------GYVLEKRDKE 22779

Query: 1561  GATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQ--EVFV 1618
             G  W         R +    L    +  L ++  YE R+S  NA G    SPP   +   
Sbjct: 22780 GIRWTRC----HKRLIGELRL---RVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKAC 22832

Query: 1619  GEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTL 1678
                     P N  V   T + + ++W  P  D    +IQGY +   +   G  T      
Sbjct: 22833 DPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDG-GCEIQGYIVEKCDVSVGEWTMCTPPT 22891

Query: 1679  FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
              + + +++++ L     Y   + A N AG G          + A    P  V+  +L   
Sbjct: 22892 GINKTNIEVEKLLEKHEYNFRICAINKAGVG----------EHADVPGPIIVE-EKLEAP 22940

Query: 1739  SVNVSWEAPQFPNGILEGYRLVYEPC----------SPVDG-VSKIVTVDVKGN-SPLWL 1786
              +++  E  +  N    G   ++ P             VDG +     +DV  + + L L
Sbjct: 22941 DIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVL 23000

Query: 1787  KVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSS 1846
                +  +   Y   +   + T    +   V   P      P  + +      +++I W  
Sbjct: 23001 DNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSP----PVNLKVTEITKDSVSITWEP 23056

Query: 1847  G-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVND 1905
                 G   I  Y++E R +    +  ++ +  K     ++ +D L+ G SY FRV A N+
Sbjct: 23057 PLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKN----SWKIDQLQEGCSYYFRVTAENE 23112

Query: 1906  YGFGTPSSPSQSV 1918
             YG G P+  +  +
Sbjct: 23113 YGIGLPAQTADPI 23125



 Score =  136 bits (343), Expect = 2e-31
 Identities = 147/574 (25%), Positives = 232/574 (40%), Gaps = 47/574 (8%)

Query: 41   GNRLVLTCMAEGSWPLEFKWLHNNREL-------TKFSLEYRYM-ITSLDRTHAGFYRCI 92
            G  +VL C   GS P+   W  +  E+       + FS     + ++ L+ +  G Y C+
Sbjct: 6755 GASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCV 6814

Query: 93   VRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGR 152
              N  G+  +    + V    SFE+      V  G +    +  I   P  +V WF+  R
Sbjct: 6815 AANVAGSD-ECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSV-IRGTPPFKVKWFKGSR 6872

Query: 153  KIPPSSRIAITLEN--TLVILSTVAP-DAGRYYVQAVNDKNGDNKTSQPITLTVENVGGP 209
            ++ P     I+LE+  T + L  V P ++G Y     ND    + T+         V  P
Sbjct: 6873 ELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLF------VKEP 6926

Query: 210  ADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGG------IS 263
            A     T +    + SV  G S + LE      P I   + W KD  L+S        ++
Sbjct: 6927 A-----TFVKRLADFSVETG-SPIVLEATYTGTPPIS--VSWIKDEYLISQSERCSITMT 6978

Query: 264  DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEME 323
            + +  L I   T  D   Y C   L  +     +  A +SVLEPP F+ EP  H+ A + 
Sbjct: 6979 EKSTILEILESTIEDYAQYSC---LIENEAGQDICEALVSVLEPPYFI-EPLEHVEAVIG 7034

Query: 324  KVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND-GGLQISGLVPDDTGMFQCFA 382
            +   + C+  G P   I+WYK+   +      + + +N+   L I+ +   D G + C A
Sbjct: 7035 EPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKA 7094

Query: 383  RNAAGEVQTSTYLAVTS--IAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGER 440
             N+ G V +S  L + +  + P   R   D     G  V   C  +G+    ++W K + 
Sbjct: 7095 DNSVGAVASSAVLVIKARKLPPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYK-DG 7153

Query: 441  ILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWAR---TR 497
            +L      L         +L I  T  S  G Y C A+N  G   +SA L++        
Sbjct: 7154 VLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPF 7213

Query: 498  ITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHI 556
                P    +  G   +  C VT      I+  W KD   +    + ++ L  N  +L +
Sbjct: 7214 FDLKPVSVDLALGESGTFKCHVT--GTAPIKITWAKDNREIRPGGNYKMTLVENTATLTV 7271

Query: 557  SQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLP 590
             +   GD G YTC   +  G DS SA L V++ P
Sbjct: 7272 LKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPP 7305



 Score =  136 bits (342), Expect = 3e-31
 Identities = 142/582 (24%), Positives = 240/582 (41%), Gaps = 58/582 (9%)

Query: 32   PVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNREL--------TKFSLEYRYMITSLDR 83
            P++  V  EG      C   G+  L+  W   ++++        T+F   Y+  I     
Sbjct: 3350 PLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYP 3408

Query: 84   THAGFYRCIVRNRMGAL------------------LQRQTEVQVAYMGSFEEGEKHQSVS 125
               G Y  +  N +G +                  ++++ E+++      +   +   V+
Sbjct: 3409 EDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVA 3468

Query: 126  HGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYY 182
             G  A      I S P  +  WF+ GR+I  S + +I      ++L IL T   D G Y 
Sbjct: 3469 LGHLAKFTC-EIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYT 3527

Query: 183  VQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANAR 242
             +A N+    + T+   TLTV       +   PT +  PK+ +   G +   + C     
Sbjct: 3528 CKASNEYGSVSCTA---TLTV------TEAYPPTFLSRPKSLTTFVGKAAKFI-CTVTGT 3577

Query: 243  PLIKLHIIWKKDGVLLSGG----ISDHNRR--LTIPNPTGSDAGYYECEAVLRSSSVPSV 296
            P+I+   IW+KDG  LS      ISD   +  L + N T  D G Y C+A   S+   + 
Sbjct: 3578 PVIET--IWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKA---SNKFGAD 3632

Query: 297  VRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR 356
            +  A L +++ P F+KE E  + + + K V + CQ       ++TW KD   +   K  +
Sbjct: 3633 ICQAELIIIDKPHFIKELEP-VQSAINKKVHLECQVDEDRKVTVTWSKDGQKLPPGKDYK 3691

Query: 357  FRQRND-GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVID 415
                +    L+I      D+G + C A N AG    S  + V      + +      ++ 
Sbjct: 3692 ICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVKKVDPSYLMLP 3751

Query: 416  GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTC 475
            G S  L C+  G+P   +TW K  + L+  +     F   E+  L I+   + D+G+Y+C
Sbjct: 3752 GESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEA-ILDITDVKVEDSGSYSC 3810

Query: 476  LATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDG 535
             A N  G D  S ++V+       K  +   +++GT A + C V+      I   W KD 
Sbjct: 3811 EAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEIS--WFKDK 3868

Query: 536  ATLGTESHPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGG 576
              + +    R+   ++   L I    S D+G Y C V +  G
Sbjct: 3869 KQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910



 Score =  136 bits (342), Expect = 3e-31
 Identities = 157/600 (26%), Positives = 242/600 (40%), Gaps = 56/600 (9%)

Query: 26   PYFKTE--PVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS--- 80
            PYF TE  P+   V   G+ + L C   G+  +   W   + +L   + EYR   T+   
Sbjct: 6079 PYFVTELEPLEAAV---GDSVSLQCQVAGTPEITVSWYKGDTKLRP-TPEYRTYFTNNVA 6134

Query: 81   ------LDRTHAGFYRCIVRNRMGALLQRQT-EVQVAYMG-SFEEGEKHQSVSHGEAAVI 132
                  ++   +G Y C   N +G    +    +Q   +  SF    K    + G    +
Sbjct: 6135 TLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTL 6194

Query: 133  RAPRIASFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDK 189
                  S P  QV W+RDG  +     +  +  +   TL IL T    +G+Y   A N  
Sbjct: 6195 TCRLNGSAPI-QVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPL 6253

Query: 190  NGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLEC-VANARPLIKLH 248
             G   +S  +T             +P   I P +  V+AG S    EC V  A+P+    
Sbjct: 6254 -GTASSSARLTAREPKK-------SPFFDIKPVSIDVIAGES-ADFECHVTGAQPM---R 6301

Query: 249  IIWKKDG---------VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 299
            I W KD           +   G + H R L +      D+G Y C+A   ++ V   +  
Sbjct: 6302 ITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGK---GDSGQYTCQA---TNDVGKDMCS 6355

Query: 300  AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYK-DAAVVEVEKLTRFR 358
            A LSV EPP+FVK+ E    A+  + + + C+  G P   ++W++ D+ + E  K     
Sbjct: 6356 AQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSF 6415

Query: 359  QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMS 418
              +   L I+    +D+G + C A N  G+   ST L V +  P  T+ P     + G  
Sbjct: 6416 INSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKA-PPVFTQKPSPVGALKGSD 6474

Query: 419  VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 478
            V+L CE SG P   + W K +R     S +    +     SL I     SD G Y C AT
Sbjct: 6475 VILQCEISGTPPFEVVWVK-DRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKAT 6533

Query: 479  NSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKD-GAT 537
            N  G D  S  +      R  K   D S + G    +   V     +++  +W KD G  
Sbjct: 6534 NEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISV--VWLKDRGEV 6591

Query: 538  LGTESHPRIR-LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHP 596
            +    + RI  +D   +L +    + + G Y C++ +  G    SA L V +     E P
Sbjct: 6592 IRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKP 6651



 Score =  133 bits (335), Expect = 2e-30
 Identities = 151/578 (26%), Positives = 242/578 (41%), Gaps = 49/578 (8%)

Query: 37   VHLEGNRLVLTCMAEGSWPLEFKWLHNN---RELTKFSLEYR-----YMITSLDRTHAGF 88
            + L G  + L     GS P+   W+      RE  K  + +       +I  +  +  G 
Sbjct: 3934 IALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGK 3993

Query: 89   YRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWF 148
            Y C+  N  G+      E+ V       E  +   V+ G+ A +    +A  P+ +  W+
Sbjct: 3994 YTCLAENEAGSQTS-VGELIVKEPAKIIERAELIQVTAGDPATLEYT-VAGTPELKPKWY 4051

Query: 149  RDGRKIPPSSRIAITLENTLVIL---STVAPDAGRYYVQAVNDKNGDNKTSQPITLTVEN 205
            +DGR +  S +  I+ +N +  L   S    D+G+Y  +  N+      +S   T TV +
Sbjct: 4052 KDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGS---SSCETTFTVLD 4108

Query: 206  VGGPADPIAPTIIIPPKNT-SVVAGTSEVTLEC-VANARPLIKLHIIWKKDGVLLSGGIS 263
                   IAP    P +N  SVV GT    L+C +A + P+    + W KDG  ++   S
Sbjct: 4109 -----RDIAPFFTKPLRNVDSVVNGTCR--LDCKIAGSLPM---RVSWFKDGKEIAA--S 4156

Query: 264  DHNR--------RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE 315
            D  R         L I     +DAG + C A   ++SV S      L V EPP FV +P 
Sbjct: 4157 DRYRIAFVEGTASLEIIRVDMNDAGNFTCRA---TNSVGSKDSSGALIVQEPPSFVTKPG 4213

Query: 316  RHITAEMEKVVDIPCQAKGVPPPSITWYK-DAAVVEVEKLTRFRQRNDGGLQISGLVPDD 374
                     V  +    +G  P +I W+K +  +V        ++  +  L++  +   D
Sbjct: 4214 SKDVLPGSAVC-LKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSD 4272

Query: 375  TGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT 434
            +G + C   N AG V+ S  L V   A  + +      +  G +  LAC+ +G P   IT
Sbjct: 4273 SGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKIT 4332

Query: 435  WQKGERILASGSVQLPRFTPLESGSLL-ISPTHISDAGTYTCLATNSRGVDEASADLVVW 493
            W   +R +   S    R + +ES ++L ++   I D+G Y C A N  G D  S+ ++V 
Sbjct: 4333 WFANDREIKESSKH--RMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVK 4390

Query: 494  ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT-ESHPRIRLDRNG 552
                 TK  +   V+K     ++  V   P   I   W KD   L +   +     D   
Sbjct: 4391 ESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEI--TWFKDNTILRSGRKYKTFIQDHLV 4448

Query: 553  SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLP 590
            SL I +  + D G Y CRV +  G+   SA + +R+ P
Sbjct: 4449 SLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPP 4486



 Score =  132 bits (331), Expect = 5e-30
 Identities = 149/604 (24%), Positives = 242/604 (40%), Gaps = 45/604 (7%)

Query: 41   GNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRY---------MITSLDRTHAGFYRC 91
            G    L    EG+ P+  +WL    E+ + S   R               +  +AG Y C
Sbjct: 5624 GEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYIC 5683

Query: 92   IVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDG 151
             ++N  G + +    + V       E     +V+ GE   +   ++A  P+  V W++DG
Sbjct: 5684 QIKND-GGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLEC-KVAGTPELSVEWYKDG 5741

Query: 152  RKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGG 208
            + +  S +   +  N   +L ILS    DAG Y  Q  N+    + T+      V +V  
Sbjct: 5742 KLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTA------VVDVSD 5795

Query: 209  PADPIAPTIIIPPKNTSVVAGTSEVTLEC-VANARPLIKLHIIWKKDGVLLSGG------ 261
             A P  P+     KNT  V G S + LEC VA + P+    + W  +   +  G      
Sbjct: 5796 RAVP--PSFTRRLKNTGGVLGASCI-LECKVAGSSPI---SVAWFHEKTKIVSGAKYQTT 5849

Query: 262  ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAE 321
             SD+   L + +   SD G Y C A   + S       A L+V EPP FVKEPE  +   
Sbjct: 5850 FSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDEC---RAVLTVQEPPSFVKEPEP-LEVL 5905

Query: 322  MEKVVDIPCQAKGVPPPSITWYKDAA-VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQC 380
              K V      +G PP  + W++ A  +V+ ++   + +     L++  +    +G + C
Sbjct: 5906 PGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTC 5965

Query: 381  FARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GE 439
               N AG+   +T L V   A  + R   D +V  G S++L    +G    ++TW+K G 
Sbjct: 5966 VVSNNAGQASCTTRLFVKEPAAFLKRLS-DHSVEPGKSIILESTYTGTLPISVTWKKDGF 6024

Query: 440  RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRIT 499
             I  S    +   T  ++  L I  +   DAG Y+C   N  G D   A +         
Sbjct: 6025 NITTSEKCNI--VTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFV 6082

Query: 500  KPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQ 558
               +      G   S+ C V   P +T+   W K    L      R     N  +L  ++
Sbjct: 6083 TELEPLEAAVGDSVSLQCQVAGTPEITVS--WYKGDTKLRPTPEYRTYFTNNVATLVFNK 6140

Query: 559  TWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDG 618
                D G YTC+  ++ G  S     R+++    P          +   + +T T   +G
Sbjct: 6141 VNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNG 6200

Query: 619  NSPL 622
            ++P+
Sbjct: 6201 SAPI 6204



 Score =  130 bits (326), Expect = 2e-29
 Identities = 330/1569 (21%), Positives = 558/1569 (35%), Gaps = 197/1569 (12%)

Query: 222   KNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV-LLSGGISDHNRR---LTIPNPTGS 277
             K  ++ AG S   +  V+   P +   I W K G+ L S  I D       L +      
Sbjct: 29454 KTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTESYSLLIVDKVNRY 29510

Query: 278   DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVV-DIPCQAKGVP 336
             DAG Y  EA  +S    + V         P   VK  E  ++ +   +  +IP    G P
Sbjct: 29511 DAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKE--VSRDSVTITWEIPTIDGGAP 29568

Query: 337   PPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 396
               +    K  A +   K T   + +    +ISGLV      F+    N  G  +      
Sbjct: 29569 VNNYIVEKREAAMRAFK-TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCE--- 29624

Query: 397   VTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILA-------SGSVQL 449
              TS A  ++  PL    ++ + V  +  T    +P   +  G R+         +G+ + 
Sbjct: 29625 -TSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPL--YDGGSRLTGYVLEACKAGTERW 29681

Query: 450   PRFTPLESGSLLISPTHISDAGTYT--CLATNSRGVDEASA--------DLVVWARTRIT 499
              +   L+   L  + T +++   Y     A N +GV E           DL V     ++
Sbjct: 29682 MKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLS 29741

Query: 500   KPPQDQ-SVIKGTQASMVCGVTHDPRVTIRYIWE----KDGATLGTESHPRIRLDRNGSL 554
               PQ    V  G    +V  +   P     + +     ++   +  E+H ++       L
Sbjct: 29742 TMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKV-----AKL 29796

Query: 555   HISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614
              I +T   D G YT  + +  G  S +  + +   P  P  P+  +  ++  +I ++W  
Sbjct: 29797 TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIK-IDEIDATSITISWEP 29855

Query: 615   P-FDGNSPLIRYILEMSENNAP-WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVG 672
             P  DG +PL  Y++E  + + P W  +  SV       T   L     Y FR+ A N  G
Sbjct: 29856 PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFT--RLTEGNEYVFRVAATNRFG 29913

Query: 673   KGQFSKDT-----ERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYI 727
              G + +         + +P  P T    +V   G T     + W PP E      + GYI
Sbjct: 29914 IGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMT-----LTWYPP-EDDGGSQVTGYI 29967

Query: 728   IRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTL 787
             +           +   +    +       L     YE  V A N+ G G   S+ ++  +
Sbjct: 29968 VERKEVRADRWVRVNKVP-VTMTRYRSTGLTEGLEYEHRVTAINARGSGK-PSRPSKPIV 30025

Query: 788   QGVPTVPPG---NVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVT 844
                P  PPG   N     T  T++   W+ P  +  + +  GY LI  +   + E T   
Sbjct: 30026 AMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVT-GY-LIEMQKVDQHEWTKCN 30083

Query: 845   ARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFS 904
               P     I    ++ L +  EY   VL     G G  +         +VPG V      
Sbjct: 30084 TTPT---KIREYTLTHLPQGAEYRFRVLACNAGGPGEPA---------EVPGTVKVTEML 30131

Query: 905   EILDTSLKVSWQE----------------PGEKNGILTGYRISWEEYNRTNTRVTHYLPN 948
             E  D  L   +QE                 G+   I    +   +   R     +     
Sbjct: 30132 EYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTE 30191

Query: 949   VTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRS 1008
             + ++    G +   TY + +     K    +    I S   PE P     L   +I  RS
Sbjct: 30192 LVIKEADRGDSG--TYDLVLENKCGKKAVYIKVRVIGSPNSPEGP-----LEYDDIQVRS 30244

Query: 1009  VTLQFRP-GYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067
             V + +RP   DG   I  +++E +         W   + + +     S+ V  L     Y
Sbjct: 30245 VRVSWRPPADDGGADILGYILERREVPKAA---W---YTIDSRVRGTSLVVKGLKENVEY 30298

Query: 1068  SFRMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY 1125
              FR+   N  G S P +    +  +T   PP+       +   +++S+ L W    +   
Sbjct: 30299 HFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKD--- 30355

Query: 1126  NGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG--- 1182
             +G     GY I+  +     K + H         YT+  L    EY+ ++ A N +G   
Sbjct: 30356 DGGSRVTGYYIE-RKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSE 30414

Query: 1183  SGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEK 1242
             + P S+ VV +     PS  P  +  L+ +  S+ ++W E PE D    +LGY V Y++ 
Sbjct: 30415 TSPASEPVVCKDPFDKPSQ-PGELEILSISKDSVTLQW-EKPECDGGKEILGYWVEYRQS 30472

Query: 1243  DSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERT-LDDVP 1301
               D+  +    E    +   + GL +   YE +V A    G   P    +  +T L    
Sbjct: 30473 -GDSAWKKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGE 30531

Query: 1302  GPPMGILFPEVRTT---SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSAR 1358
              P +     +V T    + +L  Q    P   I  Y+    L  +         ++   R
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYK-----MSSDGR 30586

Query: 1359  QYTATGL--KPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRAR 1416
              +T T +  + E   ++   A    G  E +  L++    +  P  P +           
Sbjct: 30587 THTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYY------- 30639

Query: 1417  SVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSY---- 1472
                     G+ G +   +     R +P+  W  H   +  N+ +  ++  + +T      
Sbjct: 30640 --------GAVGSTLRLHVMYIGRPVPAMTW-FHGQKLLQNSENITIENTEHYTHLVMKN 30690

Query: 1473  --------KFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQP 1524
                     K++V+ +N  G  +   + E    +Q  PD+    + +      S +I W+P
Sbjct: 30691 VQRKTHAGKYKVQLSNVFGTVDAILDVE----IQDKPDKPTGPIVIEALLKNSAVISWKP 30746

Query: 1525  PAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQY 1584
             PA+D     +  + +   E                 GA W  ++S          S+T  
Sbjct: 30747 PADDG-GSWITNYVVEKCEA--------------KEGAEWQLVSSAI--------SVTTC 30783

Query: 1585  ELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPT-----AAPRNVVVHGATATQ 1639
              + NL ++  Y  R+S  N  G    S P EV     + +      AP    +   T   
Sbjct: 30784 RIVNLTENAGYYFRVSAQNTFG---ISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDS 30840

Query: 1640  LDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVS 1699
               V W+PP  D     I+ Y +   E ++ N    V T  + E    +KNL     Y   
Sbjct: 30841 CVVAWKPPASDG-GAKIRNYYLEKRE-KKQNKWISVTTEEIRETVFSVKNLIEGLEYEFR 30898

Query: 1700  VAAFNAAGD 1708
             V   N  G+
Sbjct: 30899 VKCENLGGE 30907



 Score =  129 bits (325), Expect = 2e-29
 Identities = 159/625 (25%), Positives = 253/625 (40%), Gaps = 67/625 (10%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNREL------------TKFSLE 73
            PYF  +P    V+    R+ L  +  G+ P+  KW  +N+EL            T  SLE
Sbjct: 4768 PYFVEKPQSQDVN-PNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLE 4826

Query: 74   YRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIR 133
                + +   T +G Y C + N +G    + T          ++      + +G++    
Sbjct: 4827 ----LFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFE 4882

Query: 134  APRIASFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDKN 190
              +I   P+ +V+W+ DG +I    +  I+  +   T  I      ++G Y  +A ND  
Sbjct: 4883 C-QITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAG 4941

Query: 191  GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHII 250
                 S  I L V+          PT I   K   VV   S+V LEC     P     + 
Sbjct: 4942 ---TASCSIELKVKE--------PPTFIRELKPVEVVK-YSDVELECEVTGTP--PFEVT 4987

Query: 251  WKKDG--------VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 302
            W K+           L+  +S  N  +T  +P  SD G Y+C       S     R   +
Sbjct: 4988 WLKNNREIRSSKKYTLTDRVSVFNLHITKCDP--SDTGEYQCIVSNEGGSCSCSTR---V 5042

Query: 303  SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND 362
            ++ EPP F+K+ E + T  ++          G PP SITW KD  +++ +        + 
Sbjct: 5043 ALKEPPSFIKKIE-NTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDS 5101

Query: 363  -GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP-LDSTVIDGMSVV 420
               LQI  +    +G + C A+N +G  +   +L V   A  + +   +D T  D M+  
Sbjct: 5102 VATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMT-- 5159

Query: 421  LACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATN 479
            L C  +G P   + W K G++I+ S    +     +   S  I      D+G YT    N
Sbjct: 5160 LECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNV--ASFRIQSVMKQDSGQYTFKVEN 5217

Query: 480  SRGVDEASADLVVWART---RITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGA 536
              G     A L V  +      TK       + G+   M C V+    ++ +  W KDG 
Sbjct: 5218 DFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQ--WFKDGK 5275

Query: 537  TLGTESHPRIRL-DRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEH 595
             + T +  R+   +R+ SL ++     D   YTC+V +  G+D+ S  L V++ P     
Sbjct: 5276 EISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVK 5335

Query: 596  P----VATLSTVERRAINLTWTKPF 616
            P        STVE +AI L  T PF
Sbjct: 5336 PGRQQAIPDSTVEFKAI-LKGTPPF 5359



 Score =  129 bits (324), Expect = 3e-29
 Identities = 151/641 (23%), Positives = 253/641 (39%), Gaps = 68/641 (10%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELT---KFSLEYRYMITSLD 82
            P F  +   ++V  +G  + L C   GS  ++  W  N+ EL    K+++ +   +  L 
Sbjct: 6364 PKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLT 6423

Query: 83   RTHA-----GFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRI 137
               A     G Y C   N +G      T + V     F +         G   +++   I
Sbjct: 6424 INEASAEDSGDYICEAHNGVGDA-SCSTALTVKAPPVFTQKPSPVGALKGSDVILQC-EI 6481

Query: 138  ASFPQPQVTWFRDGRKIPPSSRIAIT---LENTLVILSTVAPDAGRYYVQAVNDKNGDN- 193
            +  P  +V W +D +++  S +  IT    + +L IL+  A D G Y+ +A N+   D  
Sbjct: 6482 SGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTC 6541

Query: 194  ----KTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHI 249
                K  +P                P  +    +TS + G +      V   +P+    +
Sbjct: 6542 SCSVKFKEP----------------PRFVKKLSDTSTLIGDAVELRAIVEGFQPI---SV 6582

Query: 250  IWKKD-GVLLSGGIS------DHNRRLTIPNPTGSDAGYYECE----AVLRSSSVPSVVR 298
            +W KD G ++    +      D+   L + +P  S++G Y C+    A +R  S      
Sbjct: 6583 VWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECS------ 6636

Query: 299  GAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFR 358
             A L+VLEP + +++PE  +T        + C   G P  S  W+KD   +  +      
Sbjct: 6637 -AVLTVLEPARIIEKPEP-MTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHIT 6694

Query: 359  QRND-GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS--IAPNITRGPLDSTVID 415
              N    L+I      D G++    +N+ G+   +  + V+   + P+  R   D   I 
Sbjct: 6695 FINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL 6754

Query: 416  GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTC 475
            G SVVL C  SG+   ++ W +    + SG      F+     +L +S    SD G YTC
Sbjct: 6755 GASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSE-NVCTLNLSLLEPSDTGIYTC 6813

Query: 476  LATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDG 535
            +A N  G DE SA L V       + P    V+ G   +    +   P   ++  W K  
Sbjct: 6814 VAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVK--WFKGS 6871

Query: 536  ATLGTESHPRIRL-DRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ----LP 590
              L       I L D    L + +    + G Y+C V +  G+ S + HL V++    + 
Sbjct: 6872 RELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPATFVK 6931

Query: 591  HAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSE 631
               +  V T S +   A   T T P   +     Y++  SE
Sbjct: 6932 RLADFSVETGSPIVLEA-TYTGTPPISVSWIKDEYLISQSE 6971



 Score =  128 bits (321), Expect = 7e-29
 Identities = 170/673 (25%), Positives = 261/673 (38%), Gaps = 90/673 (13%)

Query: 1299  DVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSAR 1358
             DVPGP   +   E     V L W+ P    G  +   +  R +            A S  
Sbjct: 13088 DVPGPVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESC- 13146

Query: 1359  QYTATGLKPESV-YLFRITAQTRKGWGEAAEA--LVVTTEKRDRPQPPSRPMVQQEDVRA 1415
             ++T TGL+   V YLFR++A+ R G GE  E    V    K D P PP    +   DV  
Sbjct: 13147 EFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTIT--DVNR 13204

Query: 1416  RSVLLSWEPGS-DGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKF 1474
               V L+WEP   DG + +  Y I+ R+  S RW       + + S+ + D ++    Y F
Sbjct: 13205 FGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEG-QEYSF 13263

Query: 1475  RVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-LSVTPHTTTSVLIRWQPPAEDKINGI 1533
             RV+A N IG  + S  +  +         +P + L+ +  T +SV ++W+PP +D  + I
Sbjct: 13264 RVRAQNRIGVGKPSAATPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPI 13323

Query: 1534  LLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHR 1593
             L                G+ +         W              P LT Y++  L K  
Sbjct: 13324 L----------------GYIIERCEEGKDNWIRCNMKLV------PELT-YKVTGLEKGN 13360

Query: 1594  RYEIRMSVYNAVGEGPSSP------PQEVFVGEAVPTAAPRN---VVVHGATATQLDVTW 1644
             +Y  R+S  N  G    S         + FV   +  +A ++   V+V       +  T 
Sbjct: 13361 KYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTG 13420

Query: 1645  EPPPLDSQN-GDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAF 1703
              P P  +   GD                    K L   +  VK+K L+ Y   ++S +  
Sbjct: 13421 YPRPTATWCFGD--------------------KVLETGDR-VKMKTLSAYAELVISPSER 13459

Query: 1704  NAAGDGPRSTPTQGQTQQ--------AAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-L 1754
             +  G        + +T          A PSAP  +KF ++T  SV+++WE P    G  L
Sbjct: 13460 SDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPL 13519

Query: 1755  EGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP---- 1810
              GY +     S      K  T  +   + L   V DL +G  Y F++ A+    GP    
Sbjct: 13520 TGYVVEKREVS-----RKTWTKVMDFVTDLEFTVPDLVQGKEYLFKVCARN-KCGPGEPA 13573

Query: 1811  EIEANVTTGPGEGAPGPP-GVPIIVRYSSAIAIHWS-SGDPGKGPITRYVIEARPSDEGL 1868
              ++  V        P PP  V    R +++I + W    + G   I  Y++E  P     
Sbjct: 13574 YVDEPVNMSTPATVPDPPENVKWRDRTANSIFLTWDPPKNDGGSRIKGYIVERCPRGSDK 13633

Query: 1869  WDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANPFYE 1928
             W        + V+     +  L+ G  Y +RV A+N  G   PS P++ + A       E
Sbjct: 13634 W----VACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPE 13689

Query: 1929  EWWFLVVIALVGL 1941
                FL V  L GL
Sbjct: 13690 --IFLDVKLLAGL 13700



 Score =  127 bits (320), Expect = 9e-29
 Identities = 317/1464 (21%), Positives = 519/1464 (35%), Gaps = 187/1464 (12%)

Query: 366   QISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP---LDSTVID------G 416
             ++ GL+  +   F+  A N  GE +    LA + IA +I   P   LD T  D      G
Sbjct: 17865 RVPGLIEGNEYRFRIKAANIVGEGEPRE-LAESVIAKDILHPPEVELDVTCRDVITVRVG 17923

Query: 417   MSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
              ++ +     G P P ITW K  ++L     ++     L    L I     +D G Y   
Sbjct: 17924 QTIRILARVKGRPEPDITWTKEGKVLVR-EKRVDLIQDLPRVELQIKEAVRADHGKYIIS 17982

Query: 477   ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGA 536
             A NS G  + SA + V  R     P Q+  V   T+ +  C ++          WE    
Sbjct: 17983 AKNSSGHAQGSAIVNVLDR---PGPCQNLKVTNVTKEN--CTIS----------WENPLD 18027

Query: 537   TLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRV---RQLPHAP 593
               G+E    I   R  +    + WS      T R+I A    +   + RV    ++   P
Sbjct: 18028 NGGSEITNFIVEYRKPN---QKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGP 18084

Query: 594   ----EHPVATLSTVERRA--------------INLTWTKP-FDGNSPLIRYILEMSENNA 634
                 + P+  ++ ++R                + L W +P +DG SP + Y +E     +
Sbjct: 18085 TIETKTPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGS 18144

Query: 635   PWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEE---PPT 691
                  +     K T   V   V  + Y+FR+   N+ G+  + K TE V + E+   P  
Sbjct: 18145 DDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVK-TEEVVVKEDLQKPVL 18203

Query: 692   APPQNVIASGRTNQSIM----IQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDA 747
                 + + + +   +I     ++ +P PE         +        L    + K  T A
Sbjct: 18204 DLKLSGVLTVKAGDTIRLEAGVRGKPFPE-------VAWTKDKDATDLTRSPRVKIDTRA 18256

Query: 748   DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTT 807
             D +   L         +  V A N+AG  V  + V      G    P  N+     +S  
Sbjct: 18257 DSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPG----PVRNLKIVDVSSDR 18312

Query: 808   IRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEY 867
                 W+ P        + G ++  +  E+ E   MV +  +         V+ L +  EY
Sbjct: 18313 CTVCWDPPED------DGGCEIQNYILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEY 18366

Query: 868   FTSVLCFTTPGDGP--RSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG-I 924
                V      G GP   S P + +T  D PG       +++    + V W  P    G  
Sbjct: 18367 IFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPPEVTKVSKEEMTVVWNPPEYDGGKS 18426

Query: 925   LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVS--AS 982
             +TGY +  +E + T     +         +V  L     Y   V A    G G+ S  + 
Sbjct: 18427 ITGYFLEKKEKHSTRWVPVNKSAIPERRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSR 18486

Query: 983   TISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVE--AQVGVVGEGE 1039
              + +  P E PGPPTN  + +    S+TL + +P YDG   I  ++VE   ++      E
Sbjct: 18487 PVVAKDPIEPPGPPTNFRVVDTTKHSITLGWGKPVYDGGAPIIGYVVEMRPKIADASPDE 18546

Query: 1040  EWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA 1099
              W   +  + +   +   V  L+    Y FR+   N VG   P++    I+  +    + 
Sbjct: 18547 GWKRCNAAA-QLVRKEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEI---LE 18602

Query: 1100  PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD 1159
             P  + L  +    + +R          G P  +   ++       G+    V   +V  D
Sbjct: 18603 PPEIDLDASMRKLVIVR---------AGCPIRLFAIVR-------GRPAPKVTWRKVGID 18646

Query: 1160  YTIE----DLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRES--------VPSSGP-TNV 1206
               +     DL +   + V +       SG +S T+V    E         + + GP +++
Sbjct: 18647 NVVRKGQVDLVDTMAFLV-IPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDL 18705

Query: 1207  SALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGL 1266
                  T +S  V W+  PE D    V  Y V  +E D  T     +       S  +T L
Sbjct: 18706 KVSDVTKTSCHVSWAP-PENDGGSQVTHYIVEKREADRKTWST--VTPEVKKTSFHVTNL 18762

Query: 1267  GKYVLYEVQVLAFTRIGDGSPSH--PPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPP 1324
                  Y  +V A    G G P+    P+L       P PP  +   E+   S  L W PP
Sbjct: 18763 VPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPP 18822

Query: 1325  AAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG 1384
                 G  +   IT             E           TGLK    Y FR+ A+   G  
Sbjct: 18823 LRDGGAKIDGYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVS 18882

Query: 1385  EAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVL-------------LSWEPGSDGLSP 1431
                EA  V  E +++  PP   M +Q  ++A   L               W+ G D +  
Sbjct: 18883 LPREAEGV-YEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEV-- 18939

Query: 1432  VRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEES 1491
                       + S   A+H A    ++S  I+  +    S  + + A N  G    ++  
Sbjct: 18940 ----------VTSSHLAVHKAD---SSSILIIKDVTRKDSGYYSLTAENSSG----TDTQ 18982

Query: 1492  ESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRG 1551
             +    +  AP        ++     +  + W  P ED  + I                  
Sbjct: 18983 KIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNI----------------TN 19026

Query: 1552  FTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVG--EGP 1609
             + +   +     W  +T++ S+      + T   +  L   + Y  R+   N  G  E  
Sbjct: 19027 YIVEKCDVSRGDW--VTALASV------TKTSCRVGKLIPGQEYIFRVRAENRFGISEPL 19078

Query: 1610  SSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGD-IQGYKIYFWEAQR 1668
             +SP         VP + P+N  V       + V W+ P  DS  G  I GY I   E + 
Sbjct: 19079 TSPKMVAQFPFGVP-SEPKNARVTKVNKDCIFVAWDRP--DSDGGSPIIGYLIERKE-RN 19134

Query: 1669  GNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPS 1728
               L  +     +         L     Y   + A N AG  P S PT+  T +     P 
Sbjct: 19135 SLLWVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPG 19194

Query: 1729  SVKFSELTTTSVNVSWEAPQFPNG 1752
               +  ++T ++V++ W  P+   G
Sbjct: 19195 KPEVIDVTKSTVSLIWARPKHDGG 19218



 Score =  127 bits (319), Expect = 1e-28
 Identities = 190/818 (23%), Positives = 304/818 (37%), Gaps = 69/818 (8%)

Query: 1126  NGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER-DYTIEDLEEW-TEYRVQVQAFNAIGS 1183
             +G  + +GY ++  R D   KT   +  DR E  ++T+  L++   EY  +V A N +G+
Sbjct: 13116 DGGSKIIGYVVE--RRDIKRKTWV-LATDRAESCEFTVTGLQKGGVEYLFRVSARNRVGT 13172

Query: 1184  GPWSQT---VVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYK 1240
             G   +T   V  R++  VP   P NV+        + + W E PE D    +  Y +  +
Sbjct: 13173 GEPVETDNPVEARSKYDVPGP-PLNVTITDVNRFGVSLTW-EPPEYDGGAEITNYVIELR 13230

Query: 1241  EKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDV 1300
             +K S        V      SA +T + +   Y  +V A  RIG G PS      +  D +
Sbjct: 13231 DKTSIRWDTAMTVRAEDL-SATVTDVVEGQEYSFRVRAQNRIGVGKPSAATPFVKVADPI 13289

Query: 1301  --PGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSAR 1358
               P PP+ +   +   +SV+L W+PP    G  +   I  R      N     +      
Sbjct: 13290 ERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIERCEEGKDNWIRCNMKLVPEL 13349

Query: 1359  QYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQE--DVRAR 1416
              Y  TGL+  + YL+R++A+ + G  + +E L   T      +P       ++  +V   
Sbjct: 13350 TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADDAFVEPTMDLSAFKDGLEVIVP 13409

Query: 1417  SVLLSWEPGSDGLSPVRYYTIQTRELPSG-RWALHSASVSHNASSFIVDRLKPFTSYKFR 1475
             + +    P +    P   +    + L +G R  + + S     +  ++   +      + 
Sbjct: 13410 NPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKTLSAY---AELVISPSERSDKGIYT 13466

Query: 1476  VKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILL 1535
             +K  N +        S  +     A   AP  L     T  SV + W+PP +D     L 
Sbjct: 13467 LKLENRV-----KTISGEIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDG-GSPLT 13520

Query: 1536  GFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRY 1595
             G+ +  RE+  +               TW ++    +    + P L Q         + Y
Sbjct: 13521 GYVVEKREVSRK---------------TWTKVMDFVTDLEFTVPDLVQ--------GKEY 13557

Query: 1596  EIRMSVYNAVGEGPSS---PPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQ 1652
               ++   N  G G  +    P  +     VP   P NV     TA  + +TW+PP  D  
Sbjct: 13558 LFKVCARNKCGPGEPAYVDEPVNMSTPATVPDP-PENVKWRDRTANSIFLTWDPPKNDG- 13615

Query: 1653  NGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRS 1712
                I+GY +      RG+         +AE  +++  L     Y   V A N  G    S
Sbjct: 13616 GSRIKGYIVE--RCPRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPS 13673

Query: 1713  TPT---QGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDG 1769
              PT   Q    Q AP     VK     T       E P    G  E  ++ +     +  
Sbjct: 13674 RPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEP-KITWTKADMILK 13732

Query: 1770  VSKIVTVD-VKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPP 1828
               K +T++ V   S + +     ++  TY              +E NV   PG     P 
Sbjct: 13733 QDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKPGP----PA 13788

Query: 1829  GVPIIVRYSSAIAIHWSSG-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSM 1887
                I    + +  + W+   D G   IT YV+E R +D  +W  L       V    F  
Sbjct: 13789 AFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWHKL----SSTVKDTNFKA 13844

Query: 1888  DILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
               L P   Y FRV A N YG G P   S      + +P
Sbjct: 13845 TKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQFDP 13882



 Score =  127 bits (318), Expect = 2e-28
 Identities = 153/659 (23%), Positives = 269/659 (40%), Gaps = 54/659 (8%)

Query: 39   LEGNRLVLTCMAEGSWPLEFKWLHNNRELTK---FSLEYRYMITSL-----DRTHAGFYR 90
            L G         +GS P+   WL ++ E+T+     + +   + SL     +  H G Y 
Sbjct: 4498 LRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYV 4557

Query: 91   CIVRNRMGALLQRQTEV-QVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFR 149
            C  +N  G  +QR + +  V    +  E      V+ G+ A ++  + +   +    WF+
Sbjct: 4558 CQAKNDAG--IQRCSALLSVKEPATITEEAVSIDVTQGDPATLQV-KFSGTKEITAKWFK 4614

Query: 150  DGRKIPPSSRIAITLENT---LVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENV 206
            DG+++   S+  I++ +T   L I+ST   D+G Y  +  ND    +  ++   L +   
Sbjct: 4615 DGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLI-- 4672

Query: 207  GGPADPIAPTIIIPPKNTSVVAGTSEVTLEC-VANARPLIKLHIIWKKDGVLLSGG---- 261
                  I P+     K    + G S + LEC VA + P+    I W KD   +S      
Sbjct: 4673 ------IPPSFTKKLKKMDSIKG-SFIDLECIVAGSHPI---SIQWFKDDQEISASEKYK 4722

Query: 262  --ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHIT 319
                D+   L I    G+D+G Y C A  ++          +L+V EPP FV++P+    
Sbjct: 4723 FSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQC---SGHLTVKEPPYFVEKPQSQDV 4779

Query: 320  AEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR-FRQRNDGGLQISGLVPDDTGMF 378
                +V  +     G  P +I W+KD   +        ++      L++      D+G +
Sbjct: 4780 NPNTRV-QLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTY 4838

Query: 379  QCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI-DGMSVVLACETSGAPRPAITWQ- 436
             C   N  G   +   L V    P   + P    V+ +G S    C+ +G P+  ++W  
Sbjct: 4839 ICQLSNDVGTATSKATLFVKE-PPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYL 4897

Query: 437  KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWART 496
             G  I A     +     L   +  IS   + ++GTY C A N  G    S +L V    
Sbjct: 4898 DGNEITAIQKHGISFIDGL--ATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEPP 4955

Query: 497  RITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNG--SL 554
               +  +   V+K +   + C VT  P   +   W K+   +   S      DR    +L
Sbjct: 4956 TFIRELKPVEVVKYSDVELECEVTGTPPFEV--TWLKNNREI-RSSKKYTLTDRVSVFNL 5012

Query: 555  HISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614
            HI++    D G Y C V + GG+ S S  + +++ P   +    T + ++  A   T+  
Sbjct: 5013 HITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSA---TFQS 5069

Query: 615  PFDGNSPL-IRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVG 672
               G+ P+ I ++ +    +    V ++ VD  AT + ++ +    S ++   A N+ G
Sbjct: 5070 TVAGSPPISITWLKDDQILDEDDNVYISFVDSVAT-LQIRSVDNGHSGRYTCQAKNESG 5127



 Score =  124 bits (311), Expect = 1e-27
 Identities = 299/1315 (22%), Positives = 478/1315 (36%), Gaps = 170/1315 (12%)

Query: 683   VSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFK 742
             VS+ + P   PP N +       S++ +W+PP +   + I     I Y L       + K
Sbjct: 14796 VSVLDTP--GPPINFVFEDIRKTSVLCKWEPPLDDGGSEI-----INYTL-------EKK 14841

Query: 743   NITDADVNNLLLED-----------LIIWTNYEIEVAAYNSAGLG--VYSSKVTEWTLQG 789
             + T  D   +++             LI    Y   V A N  G G    S  +      G
Sbjct: 14842 DKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFG 14901

Query: 790   VPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPN- 848
              P  P   +  + T+++ +   WN P        + G  ++ +  E+ E  +   +R N 
Sbjct: 14902 PPDAPDKPIVEDVTSNSML-VKWNEPK-------DNGSPILGYWLEKREVNSTHWSRVNK 14953

Query: 849   -FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEIL 907
                +++    V GL +   Y   V      G G  S P   +T  D   P G      + 
Sbjct: 14954 SLLNALKAN-VDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGP-PIPRVT 15011

Query: 908   DTS---LKVSWQEPG-EKNGILTGYRISWEEYNRTN--TRVTHYLPNVTLEYRVTGLTAL 961
             DTS   +++ W+ P     G + GY +  ++   TN  +R T  +  V  +Y V  +   
Sbjct: 15012 DTSSTTIELEWEPPAFNGGGEIVGYFVD-KQLVGTNEWSRCTEKMIKVR-QYTVKEIREG 15069

Query: 962   TTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSV----TLQFRPGY 1017
               Y + V+A+ + G+G    +   +   P+ P P   L +S  G   +    TL+     
Sbjct: 15070 ADYKLRVSAVNAAGEGPPGETQPVTVAEPQEP-PAVELDVSVKGGIQIMAGKTLRIPAVV 15128

Query: 1018  DGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIV 1077
              G+       V  +V    EGE       + N      + + D        + +   N  
Sbjct: 15129 TGRP------VPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSC 15182

Query: 1078  GTSPPSQPSRKIQTLQAPP---DMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGY 1134
             G+      + +++    P    D+ P        +     L W    + E +G  E  G+
Sbjct: 15183 GSK---FAAARVEVFDVPGPVLDLKPV-----VTNRKMCLLNWS---DPEDDGGSEITGF 15231

Query: 1135  KIKYSRSDGHGKTLSHVVQ-DRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGR 1193
              I+  R D    T    ++ +R + D T   L E  EY+ +V A N  G GP     +G 
Sbjct: 15232 IIE--RKDAKMHTWRQPIETERSKCDIT--GLLEGQEYKFRVIAKNKFGCGP--PVEIGP 15285

Query: 1194  TRESVPSSGPTNVSALA---TTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRF 1250
                  P   PT+   L     T S++ + W E P ++    + GY +   EK    +P F
Sbjct: 15286 ILAVDPLGPPTSPERLTYTERTKSTITLDWKE-PRSNGGSPIQGYII---EKRRHDKPDF 15341

Query: 1251  WLVEGN--SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGIL 1308
               V      + S  +  L ++ +YE +V A   IG+  PS P  L   + D   PP   L
Sbjct: 15342 ERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLP--LNVVIQDDEVPPTIKL 15399

Query: 1309  FPEVRTTSVRL-IWQP---PAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATG 1364
                VR  ++++   +P   PA   G+ +  +I    N T     T + L  +  + + + 
Sbjct: 15400 RLSVRGDTIKVKAGEPVHIPADVTGLPMP-KIEWSKNETVIEKPT-DALQITKEEVSRSE 15457

Query: 1365  LK-----PESVY----LFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRA 1415
              K     P++V      + +TA  R G    +    V  E  DRP PP    V   D++A
Sbjct: 15458 AKTELSIPKAVREDKGTYTVTASNRLG----SVFRNVHVEVYDRPSPPRNLAVT--DIKA 15511

Query: 1416  RSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKF 1474
              S  L+W+ P  +G S + +Y I  R+    +      + +     + + +L P   Y+F
Sbjct: 15512 ESCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEF 15571

Query: 1475  RVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGIL 1534
             RV+A N  G S+  +  + +          P    V   T  S+L+ W PP  D     +
Sbjct: 15572 RVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPL-DNGGSPI 15630

Query: 1535  LGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSL--TQYELDNLNKH 1592
              G+ +  RE   EG                +   S  S   +++  L   ++ +  L + 
Sbjct: 15631 TGYWLEKRE---EG----------------SPYWSRVSRAPITKVGLKGVEFNVPRLLEG 15671

Query: 1593  RRYEIRMSVYNAVGEGPSSPPQ--EVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLD 1650
              +Y+ R    NA G GP S P   EV      P   P    V   T + + + W+PP  D
Sbjct: 15672 VKYQFRAMAINAAGIGPPSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKD 15731

Query: 1651  SQNGDIQGYKIYFWE---AQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAG 1707
                  I+GY +   E        + E  K +   E  V   NL     Y   V A N AG
Sbjct: 15732 G-GSPIKGYIVEMQEEGTTDWKRVNEPDKLITTCECVV--PNLKELRKYRFRVKAVNEAG 15788

Query: 1708  DGPRSTPT---QGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPC 1764
             +   S  T        Q  P     +   +            P    G     R   +  
Sbjct: 15789 ESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKG-----RPTPKSS 15843

Query: 1765  SPVDGVSKIVTVDVKGNSP-----------LWLKVKDLAEGVTYRFRIRAKTFTYGPEIE 1813
                DG +K    D   + P             + + +     T ++ I AK         
Sbjct: 15844 WEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTAN 15903

Query: 1814  ANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWS-SGDPGKGPITRYVIEARPSDEGLWDIL 1872
               V      G P    V  I R S  ++  W    D G   I  YVIE R  D   W   
Sbjct: 15904 CRVKVMDVPGPPKDLKVSDITRGSCRLS--WKMPDDDGGDRIKGYVIEKRTIDGKAW--- 15958

Query: 1873  IKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANPFY 1927
                +  +  S TF +  L     Y FRV A N +G G P    Q   A+  +P Y
Sbjct: 15959 -TKVNPDCGSTTFVVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTAR--DPIY 16010



 Score =  122 bits (307), Expect = 3e-27
 Identities = 293/1394 (21%), Positives = 498/1394 (35%), Gaps = 169/1394 (12%)

Query: 590   PHAPEHPVATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKAT 648
             P  P  P  T  T  + + +L W+ P  DG S +  YI+E  E            + + T
Sbjct: 16421 PPGPPFPKVTDWT--KSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGT 16478

Query: 649   SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIM 708
              + V GL     Y+FR+ AVN  G G+  + T+ + + +    +P   + AS R    + 
Sbjct: 16479 KLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRL-VSPDLQLDASVRDRIVV- 16536

Query: 709   IQWQPPPESHQNGILKGYIIRYCLAGLP---VGYQFKNIT---DADVNNLLLEDLIIWTN 762
                      H  G+++  II Y ++G P   V +     T   +A +    +   ++  N
Sbjct: 16537 ---------HAGGVIR--IIAY-VSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKN 16584

Query: 763   YE------IEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPS 816
              +        + A N AG    +  V    + G P   P   H   TN +  + TW +P 
Sbjct: 16585 CQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPG-PVGTPFLAH-NLTNESC-KLTWFSPE 16641

Query: 817   PQFINGINQGYKLIAWEPEQEE--EVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCF 874
                 + I   Y +   E ++     VT    R N         V GL +   YF  +   
Sbjct: 16642 DDGGSPITN-YVIEKRESDRRAWTPVTYTVTRQN-------ATVQGLIQGKAYFFRIAAE 16693

Query: 875   TTPGDGP---RSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG------IL 925
              + G GP    S   ++R    VP     L   E+   ++ ++W  P    G      +L
Sbjct: 16694 NSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVL 16753

Query: 926   TGYRISWEEYNR-TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 984
                 I  E++++ TN  +      ++ +Y V GL    TY   V+A+   GQG+ S  T 
Sbjct: 16754 ESRLIGTEKFHKVTNDNL------LSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTK 16807

Query: 985   SSGVPPELPGPPTNLGISNIGPRSVTLQFRPG--------YDGKTSISRWLVEAQVGVVG 1036
                   EL  P  +L   +       L  R G        Y GK        + +  V+ 
Sbjct: 16808 PITCKDELAPPTLHLDFRD------KLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLE 16861

Query: 1037  EGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAP- 1095
             +         +   P   ++E           + +   N  G+    +   ++  +  P 
Sbjct: 16862 DDRT-----HIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSR---KGFCQVNVVDRPG 16913

Query: 1096  PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL-SHVVQD 1154
             P + P  VS    ++  + + W P  +   +G  +   Y I+       GK +   V   
Sbjct: 16914 PPVGP--VSFDEVTKDYMVISWKPPLD---DGGSKITNYIIEKKEV---GKDVWMPVTSA 16965

Query: 1155  RVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPW-SQTVVGRTRESVPSSGPTNVSALATT 1212
               +    +  L E  +Y  ++ A N  G S P  S ++  + R  VP + P        T
Sbjct: 16966 SAKTTCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDA-PDQPIVTEVT 17024

Query: 1213  SSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLY 1272
               S LV W++  +  +   +  Y +  +E  S    R      +     ++  L +   Y
Sbjct: 17025 KDSALVTWNKPHDGGKP--ITNYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQY 17082

Query: 1273  EVQVLAFTRIGDGSPSHP--PILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI 1330
             E +V A   IG G PS P  P+  +     P PP+     +    SV L WQPP    G 
Sbjct: 17083 EFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGS 17142

Query: 1331  -ILAYQITH-RLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAE 1388
              IL Y + + ++       A     +    +Y  TGL+    Y FR+ A    G  + A 
Sbjct: 17143 KILGYIVEYQKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 17202

Query: 1389  ALVVTTEKRDRPQPPS----RPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPS 1444
                    K DR +PP       M +++ ++    L         LS +    I+    P 
Sbjct: 17203 VPEPVLVK-DRLEPPELILDANMAREQHIKVGDTLR--------LSAI----IKGVPFPK 17249

Query: 1445  GRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIG------DSEFSEESESLTTLQ 1498
               W          A    +D     +  + R  A  D G      ++    ++ S+  L 
Sbjct: 17250 VTWKKEDRDAPTKAR---IDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLV 17306

Query: 1499  AAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGIN 1558
                   P  L V+     S  + W+ P +D    ++  + +  R++              
Sbjct: 17307 LDKPGPPRDLEVSEIRKDSCYLTWKEPLDDG-GSVITNYVVERRDVA------------- 17352

Query: 1559  NPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGP--SSPPQEV 1616
                A W+ L++    ++        +   +LN+  +Y  R++  N  G GP   +P    
Sbjct: 17353 --SAQWSPLSATSKKKS--------HFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIK 17402

Query: 1617  FVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVK 1676
              +    P   P+++       T++ + W  P  D     I GY +   E Q     + +K
Sbjct: 17403 ALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDG-GSPITGYLV---EYQEEGTQDWIK 17458

Query: 1677  TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRST--PTQGQTQQAAPSAPSSVKFSE 1734
                +      +  L     Y   V A N  G G   T  P + Q +   PS    VK  E
Sbjct: 17459 FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIE 17518

Query: 1735  LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
                     +   P    G+           S +    +  TV+    S + L +K+    
Sbjct: 17519 GLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIK-TDEHYTVETDNFSSV-LTIKNCLRR 17576

Query: 1795  VTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSA--IAIHWSSG-DPGK 1851
              T  ++I          +  ++T       PGPP  PI +   +   + I W    D G 
Sbjct: 17577 DTGEYQITVSNAAGSKTVAVHLTV---LDVPGPPTGPINILDVTPEHMTISWQPPKDDGG 17633

Query: 1852  GPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP 1911
              P+  Y++E + + +  W +    +    S     +  L+ G  Y FRV A N  G G P
Sbjct: 17634 SPVINYIVEKQDTRKDTWGV----VSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPP 17689

Query: 1912  SSPSQSVPAQKANP 1925
                + +V   K +P
Sbjct: 17690 LDSTPTVAKHKFSP 17703



 Score =  119 bits (299), Expect = 2e-26
 Identities = 335/1620 (20%), Positives = 584/1620 (36%), Gaps = 266/1620 (16%)

Query: 302   LSVLEPPQFVKEPERHITAEMEKVVDIPCQAK--------GVPPPSITWYKDAAVVEVEK 353
             ++ +EP + ++ P+  +  +++K V I   A         G PPP ITW K    +    
Sbjct: 29432 IAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRA 29491

Query: 354   LTRFRQRNDGGLQISGLVPD-----DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP 408
             +       D     S L+ D     D G +   A N +G+   +  + V       T GP
Sbjct: 29492 II------DTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYD-----TPGP 29540

Query: 409   LDSTVI-----DGMSVVLACET--SGAPRPAITWQKGER-------ILASGSVQLPRFTP 454
               S  +     D +++     T   GAP      +K E        +    S  L R + 
Sbjct: 29541 CPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISG 29600

Query: 455   LESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQAS 514
             L  G++            +  L  N  G+ E          + +   P    V+  T++ 
Sbjct: 29601 LVEGTMYY----------FRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKS- 29649

Query: 515   MVCGVTHDPRVTIRYIWEK---DGAT-----------LGTESHPRIRLDRNGSLHISQTW 560
                        T+   WEK   DG +            GTE   ++   +   L  + T 
Sbjct: 29650 -----------TVTLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTS 29698

Query: 561   SGDIGTYTCRVISA---GGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD 617
               +   Y  R+ +    G ++ R     V  +      P   LST+ ++ I++   +P +
Sbjct: 29699 LNEGEQYLFRIRAQNEKGVSEPRETVTAVT-VQDLRVLPTIDLSTMPQKTIHVPAGRPVE 29757

Query: 618   GNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGK---- 673
                 L+  I       A W     S   ++  VTV+          R   + D G+    
Sbjct: 29758 ----LVIPIAGRPPPAASW-FFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 29812

Query: 674   -----GQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYII 728
                  G  S+  + + L +  P   P  +     T  SI I W+PP E      L GY++
Sbjct: 29813 LKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDAT--SITISWEPP-ELDGGAPLSGYVV 29869

Query: 729   RYCLAG----LPVG-------YQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGV 777
                 A     LPV        ++F  +T+ +              Y   VAA N  G+G 
Sbjct: 29870 EQRDAHRPGWLPVSESVTRSTFKFTRLTEGN-------------EYVFRVAATNRFGIGS 29916

Query: 778   Y-SSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGY-------KL 829
             Y  S+V E         PP  +     +   +  TW  P     + +  GY       + 
Sbjct: 29917 YLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDDGGSQVT-GYIVERKEVRA 29975

Query: 830   IAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVR 889
               W    +  VTM   R            +GL +  EY   V      G G  S P    
Sbjct: 29976 DRWVRVNKVPVTMTRYRS-----------TGLTEGLEYEHRVTAINARGSGKPSRPSKPI 30024

Query: 890   THEDVPGPVGHLSFSEILDT---SLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHY 945
                D   P G      + DT   S+ ++W  P ++ G  +TGY I  ++ ++      + 
Sbjct: 30025 VAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNT 30084

Query: 946   LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLG----- 1000
              P    EY +T L     Y   V A  + G G+ +    +  V   L  P   L      
Sbjct: 30085 TPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQE 30144

Query: 1001  ---ISNIGPRSVTLQFRPGYDGKT-SISRWLVEAQ------VGVVGEGEEWLLIHQLSNE 1050
                +   G   +T+  +    GK   I +W  E Q      +    E    L+I + ++ 
Sbjct: 30145 GIFVRQGGVIRLTIPIK----GKPFPICKWTKEGQDISKRAMIATSETHTELVIKE-ADR 30199

Query: 1051  PDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASE 1110
              D+ + ++   N     +  ++ V ++G+  P+ P   ++           ++ +R    
Sbjct: 30200 GDSGTYDLVLENKCGKKAVYIK-VRVIGS--PNSPEGPLEY---------DDIQVR---- 30243

Query: 1111  TSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVE-RDYTIEDLEEWT 1169
              S+ + W P  +   +G  + +GY ++        K   + +  RV      ++ L+E  
Sbjct: 30244 -SVRVSWRPPAD---DGGADILGYILERREVP---KAAWYTIDSRVRGTSLVVKGLKENV 30296

Query: 1170  EYRVQVQAFNAIG-SGPWS--QTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEA 1226
             EY  +V A N  G S P    + V  +T  + P         L  T SS+ + WS  P+ 
Sbjct: 30297 EYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSR-PKD 30355

Query: 1227  DRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG--D 1284
             D    V GY +  KE  +D   R    +  ++    +TGL     Y+ +++A   +G  +
Sbjct: 30356 DGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYT-VTGLVPDAEYQFRIIAQNDVGLSE 30414

Query: 1285  GSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTT 1343
              SP+  P++ +   D P  P  +    +   SV L W+ P    G  IL Y + +R +  
Sbjct: 30415 TSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGD 30474

Query: 1344  TANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAE-ALVVTTEKRDRPQP 1402
             +A   + +      +Q+T  GL   + Y FR+ A+   G       A+ + T+      P
Sbjct: 30475 SAWKKSNKERIKD-KQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAP 30533

Query: 1403  PSRPMVQQEDVR-ARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSF 1461
               R  ++    +   +  LS +     L  +++Y      + S ++ + S   +H  +  
Sbjct: 30534 GIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVM 30593

Query: 1462  IVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIR 1521
               ++        +   ATN++G+ E S    S   LQA P   P                
Sbjct: 30594 TEEQEDEGV---YTCIATNEVGEVETS----SKLLLQATPQFHPGY-------------- 30632

Query: 1522  WQPPAEDKINGILLGFRIRYRELLYEGLRGFTLR------GINNPGATWAELTSMY-SMR 1574
                P ++K                Y G  G TLR      G   P  TW     +  +  
Sbjct: 30633 ---PLKEK----------------YYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSE 30673

Query: 1575  NLSRPSLTQYE---LDNLNKHR---RYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPR 1628
             N++  +   Y    + N+ +     +Y++++S  N  G   +    E+      PT    
Sbjct: 30674 NITIENTEHYTHLVMKNVQRKTHAGKYKVQLS--NVFGTVDAILDVEIQDKPDKPTGP-- 30729

Query: 1629  NVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLK 1688
              +V+         ++W+PP  D     I  Y +   EA+ G   + V +  ++  + ++ 
Sbjct: 30730 -IVIEALLKNSAVISWKPPA-DDGGSWITNYVVEKCEAKEGAEWQLVSSA-ISVTTCRIV 30786

Query: 1689  NLTGYTAYMVSVAAFNAAGDGPR---STPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE 1745
             NLT    Y   V+A N  G       S+    ++    P AP     + +T  S  V+W+
Sbjct: 30787 NLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWK 30846

Query: 1746  APQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK 1804
              P    G  +  Y L           +K ++V  +        VK+L EG+ Y FR++ +
Sbjct: 30847 PPASDGGAKIRNYYLEKREKKQ----NKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCE 30902



 Score =  118 bits (296), Expect = 6e-26
 Identities = 156/702 (22%), Positives = 269/702 (38%), Gaps = 67/702 (9%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELT-----KFSLE---YRYM 77
            P F  +P    V L G  +  T + +G+ P    W   + EL        SLE       
Sbjct: 7775 PSFVQKPDPMDV-LTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELE 7833

Query: 78   ITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRI 137
            +  +D + +G Y CIV N  G      T + +     F +     S+  G+  ++     
Sbjct: 7834 LFDVDTSQSGEYTCIVSNEAGKA-SCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGT-F 7891

Query: 138  ASFPQPQVTWFRDGRKIPPSSRIAITLENTLVIL---STVAPDAGRYYVQAVNDKNGDNK 194
               P   VTW ++G  + PS R  IT      IL   S+   DAG+Y     N    D+ 
Sbjct: 7892 TGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSC 7951

Query: 195  TSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECV---ANARPLIKLHIIW 251
            ++Q + L         +P+  ++         +AGT E+ +         RP     + +
Sbjct: 7952 SAQILILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHF 8011

Query: 252  KKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLE---PP 308
            + +   L     D N           D+G Y C+A    +SV  V    +L+V E   PP
Sbjct: 8012 RNNVATLVFNQVDIN-----------DSGEYICKA---ENSVGEVSASTFLTVQEQKLPP 8057

Query: 309  QFVKEPERHITAEMEKVVDIP----CQAKGVPPPSITWYKDAAVVEVEK--LTRFRQRND 362
             F ++       ++++ V +P    C   G  P S++WYKD   ++      T F   N 
Sbjct: 8058 SFSRQ-----LRDVQETVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLD-NT 8111

Query: 363  GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAP----NITRGPLDSTVIDGMS 418
              L I        G + C A N  G   +S  L +T        +I   P+D+ V  G S
Sbjct: 8112 ATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVV--GES 8169

Query: 419  VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 478
                C  +G     ++W K  R + SG      +    S  L +      D+G YTC A 
Sbjct: 8170 ADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLE-NSAHLTVLKVDKGDSGQYTCYAV 8228

Query: 479  NSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT----IRYIWEKD 534
            N  G D  +A L +  + R+  P   + + +  + +       + RV     I   W K+
Sbjct: 8229 NEVGKDSCTAQLNI--KERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKN 8286

Query: 535  GATLGTESHPRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAP 593
               +   S+  I    N   L + +    D G YTC+V +  G+   ++ + +++    P
Sbjct: 8287 NIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPP 8346

Query: 594  --EHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVT 651
              +  +  ++  E   + L+      G+ P+    L+      P      S       + 
Sbjct: 8347 VFDQHLTPVTVSEGEYVQLSC--HVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLE 8404

Query: 652  VKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAP 693
            ++ +  A S  + +C  ++V     +K   +V++ ++P  AP
Sbjct: 8405 LRDVAKADSGDY-VCKASNVAGSDTTK--SKVTIKDKPAVAP 8443



 Score =  115 bits (288), Expect = 5e-25
 Identities = 161/653 (24%), Positives = 252/653 (38%), Gaps = 89/653 (13%)

Query: 1299  DVPGPPMGIL-FPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTAN--TATVEVLAP 1355
             D PGPP       ++   +  L W  P    G  +   I  + + +  +  TA   V   
Sbjct: 18990 DAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIVEKCDVSRGDWVTALASVTKT 19049

Query: 1356  SARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQP---PSRPM-VQQE 1411
             S R      L P   Y+FR+ A+ R G  E      +T+ K     P   PS P   +  
Sbjct: 19050 SCR---VGKLIPGQEYIFRVRAENRFGISEP-----LTSPKMVAQFPFGVPSEPKNARVT 19101

Query: 1412  DVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFT 1470
              V    + ++W+ P SDG SP+  Y I+ +E  S  W   + ++  + + +    L    
Sbjct: 19102 KVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRS-TEYPCAGLVEGL 19160

Query: 1471  SYKFRVKATNDIGDSEFSEESESLTT-LQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDK 1529
              Y FR+ A N  G S  S+ +E +T  +   P   P ++ VT  T + +   W  P  D 
Sbjct: 19161 EYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSLI---WARPKHDG 19217

Query: 1530  INGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQ--YELD 1587
              + I+                G+ +     PG  W          N +   + Q  Y   
Sbjct: 19218 GSKII----------------GYFVEACKLPGDKWVRC-------NTAPHQIPQEEYTAT 19254

Query: 1588  NLNKHRRYEIRMSVYNAVGEGPSSPPQE--VFVGEAVPTAAPRNVV------VHGATATQ 1639
              L +  +Y+ R     AV   P S P +    + E VP     +V       V   T   
Sbjct: 19255 GLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVC 19314

Query: 1640  LDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVS 1699
             LD T    P+ + +    G  +   E  +  +   + TL L   SV  K+   YT     
Sbjct: 19315 LDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELF--SVNRKDSGDYT----- 19367

Query: 1700  VAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYR 1758
             + A N++G    +   +   +   P  P+SVK +++ +    +SWE P    G  +  Y 
Sbjct: 19368 ITAENSSGSKSATIKLKVLDK---PGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYI 19424

Query: 1759  LVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYG--------P 1810
             +     S  +      TV +   S     V+ L EG  Y+FRI A+   YG        P
Sbjct: 19425 VDKRETSRPNWAQVSATVPITSCS-----VEKLIEGHEYQFRICAEN-KYGVGDPVFTEP 19478

Query: 1811  EIEANVTTGPGEGAPGPPGVPIIVRYSSA-IAIHWSS-GDPGKGPITRYVIEARPSDEGL 1868
              I  N    PG   P     P+I   +   + + W    D G  PIT Y++E R +    
Sbjct: 19479 AIAKNPYDPPGRCDP-----PVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVN 19533

Query: 1869  WDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQ 1921
             W  + +   K +   T     L+ G  Y+FRV A+N  G G PS  S++  A+
Sbjct: 19534 WTKVNR---KPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYAR 19583



 Score =  115 bits (287), Expect = 6e-25
 Identities = 158/689 (22%), Positives = 275/689 (39%), Gaps = 62/689 (8%)

Query: 29   KTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYM---------IT 79
            K EP  +Q+  +G+   L C   G+ P++  W  N+RE+ K S ++R           +T
Sbjct: 4304 KLEP--SQLLKKGDATQLACKVTGTPPIKITWFANDREI-KESSKHRMSFVESTAVLRLT 4360

Query: 80   SLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIAS 139
             +    +G Y C  +N  G+     + + +     +   E        E  V+    +A 
Sbjct: 4361 DVGIEDSGEYMCEAQNEAGS--DHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAG 4418

Query: 140  FPQPQVTWFRDGRKIPPSSRIAITLENTLV---ILSTVAPDAGRYYVQAVNDKNGDNKTS 196
             P  ++TWF+D   +    +    +++ LV   IL  VA DAG Y  +  N+  G +  S
Sbjct: 4419 TPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEV-GSSICS 4477

Query: 197  QPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV 256
              +TL         +P  P+ I   ++TS + G +      +  + P+    + W KD  
Sbjct: 4478 ARVTLR--------EP--PSFIKKIESTSSLRGGTAAFQATLKGSLPIT---VTWLKDSD 4524

Query: 257  LLSGGISDHNRRLTIPNPTGS---------DAGYYECEAVLRSSSVPSVVRGAYLSVLEP 307
             ++    D N R+T  N   S           G Y C+A     +   + R + L  ++ 
Sbjct: 4525 EIT---EDDNIRMTFENNVASLYLSGIEVKHDGKYVCQA----KNDAGIQRCSALLSVKE 4577

Query: 308  PQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG-LQ 366
            P  + E    I         +  +  G    +  W+KD   + +    +    +    L+
Sbjct: 4578 PATITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELTLGSKYKISVTDTVSILK 4637

Query: 367  ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTS--IAPNITRGPLDSTVIDGMSVVLACE 424
            I      D+G +    +N  G       + V    I P+ T+       I G  + L C 
Sbjct: 4638 IISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECI 4697

Query: 425  TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
             +G+   +I W K ++ +++       F    +  L IS    +D+GTYTC ATN  G +
Sbjct: 4698 VAGSHPISIQWFKDDQEISASEKYKFSFHD-NTAFLEISQLEGTDSGTYTCSATNKAGHN 4756

Query: 485  EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHP 544
            + S  L V       + PQ Q V   T+  +   V     +TI+  W KD   L + +  
Sbjct: 4757 QCSGHLTVKEPPYFVEKPQSQDVNPNTRVQLKALVGGTAPMTIK--WFKDNKELHSGAAR 4814

Query: 545  RI-RLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTV 603
             + + D + SL +    + D GTY C++ +  G  +  A L V++ P   + P   L  V
Sbjct: 4815 SVWKDDTSTSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVL--V 4872

Query: 604  ERRAINLTWTKPFDGNSPL-IRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQ 662
             R   + T+     G   + + + L+ +E  A     ++ +D  AT   + G     S  
Sbjct: 4873 LRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLAT-FQISGARVENSGT 4931

Query: 663  FRLCAVNDVGKGQFSKDTERVSLPEEPPT 691
            +   A ND G    S + +     +EPPT
Sbjct: 4932 YVCEARNDAGTASCSIELK----VKEPPT 4956



 Score =  114 bits (285), Expect = 1e-24
 Identities = 351/1625 (21%), Positives = 576/1625 (35%), Gaps = 260/1625 (16%)

Query: 326   VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARN 384
             V+IP    G P P++TW K   +++  +   F        L I+  V  D+G +   ARN
Sbjct: 21085 VEIP--VLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARN 21142

Query: 385   AAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILAS 444
               GEV     + V  I P    GP+    +    V              +W   E     
Sbjct: 21143 IVGEVGDVITIQVHDI-PGPPTGPIKFDEVSSDFV------------TFSWDPPEN---D 21186

Query: 445   GSVQLPRF----------TPLESGSLLISPTHISDAGT------YTCLATNSRGVDE--A 486
             G V +  +          T +E  + +I  T+ +   T      +   A N  GV     
Sbjct: 21187 GGVPISNYVVEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGIT 21246

Query: 487   SADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRI 546
             SA +V     ++  PP    V   T+ SM     H+P          DG +     H   
Sbjct: 21247 SACIVANYPFKVPGPPGTPQVTAVTKDSMTIS-WHEPL--------SDGGSPILGYHVE- 21296

Query: 547   RLDRNGSLHISQTWS-----GDIGTYTCRVISAGGNDSRSAHLRV-------RQLPHAPE 594
             R +RNG L   QT S     G+I        S+G  D  +   RV       +  P  P 
Sbjct: 21297 RKERNGILW--QTVSKALVPGNI------FKSSGLTDGIAYEFRVIAENMAGKSKPSKPS 21348

Query: 595   HPVATLSTVE-----------RRAINLTWTKP-FDGNSPLIRYILEMSE-NNAPWTVLLA 641
              P+  L  ++           R  + L W KP + G   +  YI+E  +  N  W     
Sbjct: 21349 EPMLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANF 21408

Query: 642   SVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASG 701
             S +      TV GL    +Y+FR+ A N  G      +        +   AP   V    
Sbjct: 21409 S-NILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKF 21467

Query: 702   RTNQSIM----------IQWQPPPE---SHQNGILKGYIIRYCLAGLPVGYQFKNITDAD 748
             +    +           +  +PPP    S     L+G       A L +      I D  
Sbjct: 21468 KDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEG------TAKLEI-----KIADFS 21516

Query: 749   VNNLLLEDLIIWTNYEIEVAAYNSAGLG--VYSSKVTEWTLQGVPTVPPGNVHAEATNST 806
               NL+ +D     +    + A N  G    +++ KV +      P  P G +      S 
Sbjct: 21517 -TNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLD-----RPGPPEGPLAVTEVTSE 21570

Query: 807   TIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTE 866
                 +W  P        + G K+  +  ++ E   +       +  +    V+ L K  E
Sbjct: 21571 KCVLSWFPPLD------DGGAKIDHYIVQKRETSRLAWTNVASEVQVTKLKVTKLLKGNE 21624

Query: 867   YFTSVLCFTTPGDGP--RSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI 924
             Y   V+     G G    S P L       P P  +   + I   S+ V W  P    G 
Sbjct: 21625 YIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGS 21684

Query: 925   -LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAST 983
              +  Y +   +         +      L Y+V+GLT    Y   + A  + G   +SA +
Sbjct: 21685 EIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAG---ISAPS 21741

Query: 984   ISSGVPPEL-----PGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGE 1037
              +S           PGPP N  + +    S+++ + +P YDG + I+ ++VE     + E
Sbjct: 21742 PTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEI---ALPE 21798

Query: 1038  GEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPS--QPSRKIQTLQAP 1095
              +EW ++   +    A S  +  L     Y  R+  +N  G   P+    + K +    P
Sbjct: 21799 EDEWQIVTPPAG-LKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLP 21857

Query: 1096  PDM-----APANVSLRTASETSLW--LRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL 1148
             P++         V++R      L+  ++  P PE             +K++R   HG++L
Sbjct: 21858 PEIELDADLRKVVTIRACCTLRLFVPIKGRPAPE-------------VKWARD--HGESL 21902

Query: 1149  SHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSA 1208
                         +IE    +T   + V   N   SG +  TV      S   S   NV  
Sbjct: 21903 DKA---------SIESTSSYT--LLIVGNVNRFDSGKYILTV---ENSSGSKSAFVNVRV 21948

Query: 1209  LAT------------TSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256
             L T            T +S+ + W + P  D    +  Y V   EK   T+  +  V  N
Sbjct: 21949 LDTPGPPQDLKVKEVTKTSVTLTW-DPPLLDGGSKIKNYIV---EKRESTRKAYSTVATN 22004

Query: 1257  SSRSA-QLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT 1315
               +++ ++  L +   Y  +VLA    G G P+      +   + P PP  I   +V   
Sbjct: 22005 CHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKA-SERPLPPGKITLMDVTRN 22063

Query: 1316  SVRLIWQPPAAPNGI-ILAY--QITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYL 1372
             SV L W+ P    G  IL Y  ++  + +   A  ATV+V      + T TGL     Y 
Sbjct: 22064 SVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWATCATVKV-----TEATITGLIQGEEYS 22118

Query: 1373  FRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPM-------VQQEDVRARSVLLSWEPG 1425
             FR++AQ  KG  +  + L V    +D   PP+  +       +  ED++     +     
Sbjct: 22119 FRVSAQNEKGISDPRQ-LSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIG---- 22173

Query: 1426  SDGLSPVRYYTIQTRELPSGRWA-LHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGD 1484
                  P    T     +P  +   +++ S  +N+   I D  +    + + VK TN  G 
Sbjct: 22174 ----RPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGH-YVVKLTNSAG- 22227

Query: 1485  SEFSEESESLTTLQAAPDEAPT-ILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRE 1543
                 E  E+L  +       PT  + +   T  S+ + W PP  D  + I          
Sbjct: 22228 ----EAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSI---------- 22273

Query: 1544  LLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYN 1603
                     + +   +    TW  +++  +         T  +   L     Y+ R++  N
Sbjct: 22274 ------NNYIVEKRDTSTTTWQIVSATVAR--------TTIKACRLKTGCEYQFRIAAEN 22319

Query: 1604  AVGEGP--SSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKI 1661
               G+    +S P        VP   P   VV  ++   ++V W  P  D     + GY +
Sbjct: 22320 RYGKSTYLNSEPTVAQYPFKVP-GPPGTPVVTLSSRDSMEVQWNEPISDG-GSRVIGYHL 22377

Query: 1662  YFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQ 1721
                E +   L  ++    + +   K   L     Y   V+A N  G G  S  ++    +
Sbjct: 22378 ERKE-RNSILWVKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVAR 22436

Query: 1722  AAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKG 1780
                  P   +   +T  SV + W+ P +  G  + GY +V +   P     K    ++  
Sbjct: 22437 DPCDPPGRPEAIIVTRNSVTLQWKKPTYDGGSKITGY-IVEKKELPEGRWMKASFTNIID 22495

Query: 1781  NSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTG--PGEGAPGPPGVPIIVRYSS 1838
                   +V  L E   Y FR+ A+    G   E + +TG         PP + +  +Y  
Sbjct: 22496 TH---FEVTGLVEDHRYEFRVIARN-AAGVFSEPSESTGAITARDEVDPPRISMDPKYKD 22551

Query: 1839  AIAIH 1843
              I +H
Sbjct: 22552 TIVVH 22556



 Score =  112 bits (280), Expect = 4e-24
 Identities = 148/591 (25%), Positives = 244/591 (41%), Gaps = 58/591 (9%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITS---LD 82
            P F  +   + + L G    L C  +GS  ++  W  NN+EL++ +    Y + S   LD
Sbjct: 3737 PSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILD 3796

Query: 83   RT-----HAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRI 137
             T      +G Y C   N +G+     TE+ +    SF +  +   +  G  A+++    
Sbjct: 3797 ITDVKVEDSGSYSCEAVNDVGS-DSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVS 3855

Query: 138  ASFPQPQVTWFRDGRKIPPSSRIAITLENTLV---ILSTVAPDAGRYYVQAVNDKNGDNK 194
             + P  +++WF+D ++I  S +  +  + +LV   I S  + D G Y     N+      
Sbjct: 3856 GTGPF-EISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANE------ 3908

Query: 195  TSQPITLTVENVGGPADPI--APTIIIPPKNTSVVAGTSEVTLE-CVANARPL----IKL 247
                    V   G  A  +   P   +   +  +  G   VTL+  V  + P+    +K 
Sbjct: 3909 --------VGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKG 3960

Query: 248  HIIWKKDGVL---LSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304
              + ++DG +    S G++     L IP+   S  G Y C A   + S  SV     L V
Sbjct: 3961 QEVIREDGKIKMSFSNGVA----VLIIPDVQISFGGKYTCLAENEAGSQTSV---GELIV 4013

Query: 305  LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND-G 363
             EP + ++  E  I         +     G P     WYKD   +   K  R   +N+  
Sbjct: 4014 KEPAKIIERAEL-IQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVA 4072

Query: 364  GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV--TSIAPNITRGPLDS--TVIDGMSV 419
             L+       D+G +     N  G     T   V    IAP  T+ PL +  +V++G + 
Sbjct: 4073 QLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTK-PLRNVDSVVNG-TC 4130

Query: 420  VLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLAT 478
             L C+ +G+    ++W K G+ I AS   ++       + SL I    ++DAG +TC AT
Sbjct: 4131 RLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVE--GTASLEIIRVDMNDAGNFTCRAT 4188

Query: 479  NSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL 538
            NS G  ++S  L+V         P  + V+ G+   +         +TIR  W K    L
Sbjct: 4189 NSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIR--WFKGNKEL 4246

Query: 539  GTESHPRIRLDR-NGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ 588
             +     I  +    SL +    + D GTYTC+V +  G    SA+L V++
Sbjct: 4247 VSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKE 4297



 Score =  112 bits (279), Expect = 5e-24
 Identities = 145/601 (24%), Positives = 232/601 (38%), Gaps = 58/601 (9%)

Query: 137  IASFPQPQVTWFRDGRKIPPSSRIAIT---LENTLVILSTVAPDAGRYYVQAVNDKNGDN 193
            I+  PQP+++W+++ + +    +        E TL+++     DA  Y  +A ND  G  
Sbjct: 3262 ISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDY-GVA 3320

Query: 194  KTSQPITLTVENVGGPAD--PIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIW 251
             TS  +++ V  V  P    P+ P  II P   +V +       +C  +   L    + W
Sbjct: 3321 TTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQPARFQCRVSGTDL---KVSW 3377

Query: 252  -KKDGVLLSGGIS-----DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 305
              KD  +           +   +L I      D G Y   A   S++V  V   A LS+ 
Sbjct: 3378 YSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVA---SNAVGQVSSTANLSLE 3434

Query: 306  EPPQFVKEP-ERHITAEMEK-----------------VVDIPCQAKGVPPPSITWYKDAA 347
             P   + E  E+ I  EM+                  +    C+ +  P     W+K   
Sbjct: 3435 APESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGR 3494

Query: 348  -VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT-SIAPNIT 405
             + E +K +    +    L+I      D G + C A N  G V  +  L VT +  P   
Sbjct: 3495 EIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFL 3554

Query: 406  RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL-ISP 464
              P   T   G +    C  +G P     WQK    L+       R +  E+  +L +S 
Sbjct: 3555 SRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNW--RISDAENKHILELSN 3612

Query: 465  THISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 524
              I D G Y+C A+N  G D   A+L++  +    K  +        +  + C V  D +
Sbjct: 3613 LTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKVHLECQVDEDRK 3672

Query: 525  VTIRYIWEKDGATLGTESHPRIRL-DRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
            VT+   W KDG  L      +I   D+  +L I      D GTY C   +  G+ S SA 
Sbjct: 3673 VTVT--WSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSAT 3730

Query: 584  LRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYI-----LEMSENNAPWTV 638
            + VR+ P   +    +   +   +  L         SP+I+        E+SE+N   TV
Sbjct: 3731 VTVREPPSFVKKVDPSYLMLPGESARLHCKLK---GSPVIQVTWFKNNKELSESN---TV 3784

Query: 639  LLASVDPKA-TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNV 697
             +  V+ +A   +T   +  + SY     AVNDVG    S +      P    T  P ++
Sbjct: 3785 RMYFVNSEAILDITDVKVEDSGSYSCE--AVNDVGSDSCSTEIVIKEPPSFIKTLEPADI 3842

Query: 698  I 698
            +
Sbjct: 3843 V 3843



 Score =  110 bits (275), Expect = 2e-23
 Identities = 139/629 (22%), Positives = 246/629 (39%), Gaps = 71/629 (11%)

Query: 30   TEPVRTQVHLEGNRLV-------LTCMAEGSWPLEFKWLHNNRELTKFSLEYR------- 75
            TEP +    LE +++V       L C   GS  +   W  N  EL   S +YR       
Sbjct: 5420 TEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPA-SDKYRMTFIDSV 5478

Query: 76   --YMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEK-HQSVSHGEAAVI 132
                + +L    +G + C  +N  G+     T+V V     F       +++ + E ++ 
Sbjct: 5479 AVIQMNNLSTEDSGDFICEAQNPAGS-TSCSTKVIVKEPPVFSSFPPIVETLKNAEVSL- 5536

Query: 133  RAPRIASFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDK 189
                ++  P  +V W++D R++  S +  I  +N   ++ IL+    D G Y+ +A N+ 
Sbjct: 5537 -ECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEV 5595

Query: 190  NGDN-----KTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPL 244
              D      K  +P                P  +    + +VVAG        +  A+P+
Sbjct: 5596 GSDTCVCTVKLKEP----------------PRFVSKLNSLTVVAGEPAELQASIEGAQPI 5639

Query: 245  IKLHIIWKKDGVLLSGGIS----DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA 300
                +  K++ +  S  I     ++   L       ++AG Y C+         ++   A
Sbjct: 5640 FVQWLKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENM---A 5696

Query: 301  YLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR 360
             L VLEP   V E    +T  + +   + C+  G P  S+ WYKD  ++   +  +F   
Sbjct: 5697 TLMVLEPAVIV-EKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFY 5755

Query: 361  ND-GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVT--SIAPNITRGPLDSTVIDGM 417
            N    L+I  +   D G +    +N  G+   +  + V+  ++ P+ TR   ++  + G 
Sbjct: 5756 NKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGA 5815

Query: 418  SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
            S +L C+ +G+   ++ W   +  + SG+     F+     +L ++    SD G YTC+A
Sbjct: 5816 SCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSD-NVCTLQLNSLDSSDMGNYTCVA 5874

Query: 478  TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGAT 537
             N  G DE  A L V       K P+   V+ G   +    +   P   +   W +    
Sbjct: 5875 ANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPPFKVN--WFRGARE 5932

Query: 538  LGTESHPRIRL-DRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ----LPHA 592
            L       I   D    L +        G YTC V +  G  S +  L V++    L   
Sbjct: 5933 LVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAAFLKRL 5992

Query: 593  PEHPVATLSTVERRA-------INLTWTK 614
             +H V    ++   +       I++TW K
Sbjct: 5993 SDHSVEPGKSIILESTYTGTLPISVTWKK 6021



 Score =  110 bits (274), Expect = 2e-23
 Identities = 129/573 (22%), Positives = 230/573 (40%), Gaps = 52/573 (9%)

Query: 40   EGNRLVLTCMAEGSWPLEFKWLHNNRELTK---FSLEYR-----YMITSLDRTHAGFYRC 91
            E + + L C+  G+  L+ KWL + +++     FS+ +      + I S+ +  +G Y  
Sbjct: 5154 EKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTF 5213

Query: 92   IVRNRMGA------LLQRQTEVQVAYMGSFEEGEKHQSVS-HGEAAVIRAPRIASFPQPQ 144
             V N  G+      L      +  ++     + +K    S H E  V  +  I++     
Sbjct: 5214 KVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISA----- 5268

Query: 145  VTWFRDGRKIPPSSRIAITLENTLVIL--STVAPDAGRYYVQAVNDKNGDNKTSQPITLT 202
              WF+DG++I  S++  +      V L  + +  +    Y   V++  GD+  S  +T+ 
Sbjct: 5269 -QWFKDGKEISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVK 5327

Query: 203  VENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV-LLSG- 260
                    +P  P+ ++ P     +   S V  + +    P  K+   W KD V L+SG 
Sbjct: 5328 --------EP--PSFLVKPGRQQAIPD-STVEFKAILKGTPPFKIK--WFKDDVELVSGP 5374

Query: 261  ----GISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPER 316
                G+      L + +   S  G Y C     ++ V S      L V EPP+FVK+ E 
Sbjct: 5375 KCFIGLEGSTSFLNLYSVDASKTGQYTCHV---TNDVGSDSCTTMLLVTEPPKFVKKLEA 5431

Query: 317  HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQR---NDGGLQISGLVPD 373
                +      + C+  G P   + W+++    E+    ++R     +   +Q++ L  +
Sbjct: 5432 SKIVKAGDSSRLECKIAGSPEIRVVWFRNEH--ELPASDKYRMTFIDSVAVIQMNNLSTE 5489

Query: 374  DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
            D+G F C A+N AG    ST + V    P  +  P     +    V L CE SG P   +
Sbjct: 5490 DSGDFICEAQNPAGSTSCSTKVIVKE-PPVFSSFPPIVETLKNAEVSLECELSGTPPFEV 5548

Query: 434  TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 493
             W K +R L S            + S+ I     SD G Y C A N  G D     + + 
Sbjct: 5549 VWYKDKRQLRSSKKYKIASKNFHT-SIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLK 5607

Query: 494  ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGS 553
               R        +V+ G  A +   +     + ++++ EK+     +E+     ++   +
Sbjct: 5608 EPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVAT 5667

Query: 554  LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRV 586
            L  ++    + G Y C++ + GG     A L V
Sbjct: 5668 LQFAKAEPANAGKYICQIKNDGGMRENMATLMV 5700



 Score =  108 bits (269), Expect = 7e-23
 Identities = 140/589 (23%), Positives = 219/589 (37%), Gaps = 50/589 (8%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELT---KFSLEY-----RYM 77
            P F  +P    V   G      C   G+  +   W  +  E+T   K  + +      + 
Sbjct: 4861 PQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQ 4920

Query: 78   ITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRI 137
            I+     ++G Y C  RN  G       E++V    +F    K   V       +    +
Sbjct: 4921 ISGARVENSGTYVCEARNDAGTA-SCSIELKVKEPPTFIRELKPVEVVKYSDVELEC-EV 4978

Query: 138  ASFPQPQVTWFRDGRKIPPSSRIAITLENT---LVILSTVAPDAGRYYVQAVNDKNGDNK 194
               P  +VTW ++ R+I  S +  +T   +   L I      D G Y    V+++ G   
Sbjct: 4979 TGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQC-IVSNEGGSCS 5037

Query: 195  TSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKD 254
             S  + L         +P  P+ I   +NT+ V  +S      VA + P+    I W KD
Sbjct: 5038 CSTRVALK--------EP--PSFIKKIENTTTVLKSSATFQSTVAGSPPI---SITWLKD 5084

Query: 255  GVLLSG------GISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP 308
              +L           D    L I +     +G Y C+A   S         A+L V EP 
Sbjct: 5085 DQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCY---AFLLVQEPA 5141

Query: 309  QFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA-VVEVEKLTRFRQRNDGGLQI 367
            Q V++ +     E + +  + C   G P   + W KD   +V     +   + N    +I
Sbjct: 5142 QIVEKAKSVDVTEKDPMT-LECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRI 5200

Query: 368  SGLVPDDTGMFQCFARNAAGEVQTSTYLAVT--SIAPNITRGPLDSTVIDGMSVVLACET 425
              ++  D+G +     N  G      YL V   +I P+ T+       + G S+ + C+ 
Sbjct: 5201 QSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKV 5260

Query: 426  SGAPRPAITWQK-GERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
            SG+   +  W K G+ I  S   +L       S SL ++   + D   YTC  +N  G D
Sbjct: 5261 SGSLPISAQWFKDGKEISTSAKYRLVCHE--RSVSLEVNNLELEDTANYTCKVSNVAGDD 5318

Query: 485  EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHP 544
              S  L V         P  Q  I  +       +   P   I+  W KD   L   S P
Sbjct: 5319 ACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIK--WFKDDVEL--VSGP 5374

Query: 545  RIRLDRNGSLHISQTWSGDI---GTYTCRVISAGGNDSRSAHLRVRQLP 590
            +  +   GS      +S D    G YTC V +  G+DS +  L V + P
Sbjct: 5375 KCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPP 5423



 Score =  105 bits (263), Expect = 4e-22
 Identities = 280/1353 (20%), Positives = 493/1353 (36%), Gaps = 159/1353 (11%)

Query: 621   PLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT 680
             P  +   +  + +AP T     V P  + + ++         + L   N  G    S   
Sbjct: 17246 PFPKVTWKKEDRDAP-TKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSV-- 17302

Query: 681   ERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQ 740
              +V + ++P   PP+++  S     S  + W+ P +   + I    + R  +A      Q
Sbjct: 17303 -KVLVLDKP--GPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASA----Q 17355

Query: 741   FKNIT-DADVNNLLLEDLIIWTNYEIEVAAYNSAGLG--VYSSKVTEWTLQGVPTVPPGN 797
             +  ++  +   +   + L     Y   VAA N  G G  V + K  +      P  PP +
Sbjct: 17356 WSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKD 17415

Query: 798   VHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF 857
             +H    + T +   WN P     + I  GY L+ ++ E  ++        N +       
Sbjct: 17416 LHHVDVDKTEVSLVWNKPDRDGGSPIT-GY-LVEYQEEGTQDWIKFKTVTNLEC-----V 17468

Query: 858   VSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVS--- 914
             V+GL++   Y   V      G G   T   +   E +  P   L    I    +K     
Sbjct: 17469 VTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTV 17528

Query: 915   ---------------WQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLT 959
                            W   G +      Y +  + ++   T + + L   T EY++T   
Sbjct: 17529 RFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLT-IKNCLRRDTGEYQITVSN 17587

Query: 960   ALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTN-LGISNIGPRSVTLQFRPGYD 1018
             A  + T+ V                      ++PGPPT  + I ++ P  +T+ ++P  D
Sbjct: 17588 AAGSKTVAVHLTVL-----------------DVPGPPTGPINILDVTPEHMTISWQPPKD 17630

Query: 1019  -GKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIV 1077
              G + +  ++VE Q       + W ++   S++     +++P L     Y FR+R  N +
Sbjct: 17631 DGGSPVINYIVEKQDT---RKDTWGVVSSGSSKT---KLKIPHLQKGCEYVFRVRAENKI 17684

Query: 1078  GTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIK 1137
             G  PP   +  +   +  P   P    +   +E +  + W  LP+ +  G     GY ++
Sbjct: 17685 GVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWT-LPKSD--GGSPITGYYME 17741

Query: 1138  YSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPW-SQTVVGRTR 1195
               R +  GK +        +  + +  L E   Y  +V A N  G S P  S   +   R
Sbjct: 17742 --RREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACR 17799

Query: 1196  ESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEG 1255
                P   P N      +  +  + W++ P +D    +LGY V  ++  +    R    E 
Sbjct: 17800 PIKPPGPPINPKLKDKSRETADLVWTK-PLSDGGSPILGYVVECQKPGTAQWNRINKDEL 17858

Query: 1256  NSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSH--PPILERTLDDVPGPPMGILFPEVR 1313
                 + ++ GL +   Y  ++ A   +G+G P      ++ + +   P   + +   +V 
Sbjct: 17859 IRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVI 17918

Query: 1314  TT----SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPES 1369
             T     ++R++ +    P   I  +    ++         ++ L     Q          
Sbjct: 17919 TVRVGQTIRILARVKGRPEPDI-TWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHG 17977

Query: 1370  VYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDG 1428
              Y+  I+A+   G  + +  + V     DRP P     V   +V   +  +SWE P  +G
Sbjct: 17978 KYI--ISAKNSSGHAQGSAIVNVL----DRPGPCQNLKVT--NVTKENCTISWENPLDNG 18029

Query: 1429  LSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFS 1488
              S +  + ++ R+     W++ ++ V+      I   L     Y FRV A N +G     
Sbjct: 18030 GSEITNFIVEYRKPNQKGWSIVASDVTKR---LIKANLLANNEYYFRVCAENKVGVGPTI 18086

Query: 1489  EESESLTTLQAA--PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLY 1546
             E    +  +     P E P  L +     T V ++W+ P  D      L + +  R    
Sbjct: 18087 ETKTPILAINPIDRPGE-PENLHIADKGKTFVYLKWRRPDYDG-GSPNLSYHVERR---- 18140

Query: 1547  EGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVG 1606
                    L+G ++    W E     S++       T Y +D   +++ YE R+   N  G
Sbjct: 18141 -------LKGSDD----W-ERVHKGSIKE------THYMVDRCVENQIYEFRVQTKNEGG 18182

Query: 1607  EGPSSPPQEVFVGEAVPT-------AAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGY 1659
             E      +EV V E +         +    V        +  V  +P P  +   D    
Sbjct: 18183 ESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDAT 18242

Query: 1660  KIYFWEAQRGNLTERVKTLFLAENS----VKLKNLTGYTAYMVSVAAFNAAGDGPRSTPT 1715
              +          + RVK    A++S     K K   G   Y+V+  A N AG        
Sbjct: 18243 DL--------TRSPRVKIDTRADSSKFSLTKAKRSDG-GKYVVT--ATNTAGSFVAYATV 18291

Query: 1716  QGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGV--SKI 1773
                 +   P    ++K  ++++    V W+ P+   G  E    + E C     V  +  
Sbjct: 18292 NVLDK---PGPVRNLKIVDVSSDRCTVCWDPPEDDGGC-EIQNYILEKCETKRMVWSTYS 18347

Query: 1774  VTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT-FTYGPEIEANVTTGPGE----GAPGPP 1828
              TV   G +     V  L EG  Y FR+RA+     GP  E+       +    G P PP
Sbjct: 18348 ATVLTPGTT-----VTRLIEGNEYIFRVRAENKIGTGPPTESKPVIAKTKYDKPGRPDPP 18402

Query: 1829  GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMD 1888
              V  + +    +  +    D GK  IT Y +E +      W  + K     +      + 
Sbjct: 18403 EVTKVSKEEMTVVWNPPEYDGGKS-ITGYFLEKKEKHSTRWVPVNKSA---IPERRMKVQ 18458

Query: 1889  ILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQ 1921
              L P   Y FRV A N+ G G PS PS+ V A+
Sbjct: 18459 NLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAK 18491



 Score =  100 bits (248), Expect = 2e-20
 Identities = 154/690 (22%), Positives = 263/690 (38%), Gaps = 56/690 (8%)

Query: 76    YMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRA- 134
             + +TSLD      +R   +N++G     + +  +      E  E     S  +  ++RA 
Sbjct: 18562 FTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAG 18621

Query: 135   ------PRIASFPQPQVTWFRDG--RKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAV 186
                     +   P P+VTW + G    +       +     LVI ++   D+G+Y +  V
Sbjct: 18622 CPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLV 18681

Query: 187   NDKNGDNKTSQPITLTVENVGGPADPIAPTIII---------PPKNTSVVAGTSEVTLEC 237
             N      + +  + + V +  GP   +  + +          PP+N      T  +  + 
Sbjct: 18682 NPAG---EKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKR 18738

Query: 238   VANARPLIKLHIIWKKDGVLLSGGI--SDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPS 295
              A+ +    +    KK    ++  +  +++  R+T  N  G        + VL S     
Sbjct: 18739 EADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDP--- 18795

Query: 296   VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPS--ITWYKDAAVVEVEK 353
                   LS  +PP+ ++  E  +T     +  +P    G       IT Y++      ++
Sbjct: 18796 ------LSEPDPPRKLEVTE--MTKNSATLAWLPPLRDGGAKIDGYITSYREEEQ-PADR 18846

Query: 354   LTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAG----EVQTSTYLAVTSIAPNITRGPL 409
              T +    D  L ++GL       F+  ARNA G          Y A   + P     P 
Sbjct: 18847 WTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKILMPE 18906

Query: 410   DSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISD 469
               T+  G  + +     G P P   W+KGE  + + S  L       S  L+I      D
Sbjct: 18907 QITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSS-HLAVHKADSSSILIIKDVTRKD 18965

Query: 470   AGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT--I 527
             +G Y+  A NS G D     +VV       +PP D S I     S+   +  +   +   
Sbjct: 18966 SGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 19025

Query: 528   RYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGG-NDSRSAHLRV 586
              YI EK   + G        + +  S  + +   G    +  R  +  G ++  ++   V
Sbjct: 19026 NYIVEKCDVSRGDWVTALASVTKT-SCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMV 19084

Query: 587   RQLPHA-PEHPV-ATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASV 643
              Q P   P  P  A ++ V +  I + W +P  DG SP+I Y++E  E N+   V     
Sbjct: 19085 AQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDT 19144

Query: 644   DPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVS--LPEEPPTAPPQNVIASG 701
               ++T     GLV    Y FR+ A+N  G    SK TE V+  +P +PP  P    +   
Sbjct: 19145 LVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDV--- 19201

Query: 702   RTNQSIMIQWQPPPESHQNGILKGYIIRYC 731
              T  ++ + W  P     + I+ GY +  C
Sbjct: 19202 -TKSTVSLIWARPKHDGGSKII-GYFVEAC 19229



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 141/605 (23%), Positives = 223/605 (36%), Gaps = 65/605 (10%)

Query: 26   PYF--KTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNREL---TKFSLEYRYMITS 80
            PYF  + EPV+  V   G+   L C   G+  +   W   + +L   T + + +R  + +
Sbjct: 7961 PYFVKQLEPVKVSV---GDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVAT 8017

Query: 81   L-----DRTHAGFYRCIVRNRMGALLQRQ--TEVQVAYMGSFEEGEKHQSVSHGEAAVIR 133
            L     D   +G Y C   N +G +      T  +     SF    +    + G   V  
Sbjct: 8018 LVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFD 8077

Query: 134  APRIASFPQPQVTWFRDGRKIPPSSRIAIT-LENT--LVILSTVAPDAGRYYVQAVNDKN 190
                 S P   V+W++DG+ +  S  +  + L+NT  L I  T    AG+Y   A N   
Sbjct: 8078 CAISGSEPI-SVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPI- 8135

Query: 191  GDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHII 250
            G   +S  + LT     G   P     + P      V G S    EC       IK  + 
Sbjct: 8136 GSASSSARLILTE----GKNPPFFDIRLAP---VDAVVGES-ADFECHVTGTQPIK--VS 8185

Query: 251  WKKDG-VLLSGG-----ISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304
            W KD   + SGG       +++  LT+      D+G Y C AV          +      
Sbjct: 8186 WAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKER 8245

Query: 305  LEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG- 363
            L PP F K     +         +  +  G  P ++ WYK+   ++         +N+  
Sbjct: 8246 LIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTL 8305

Query: 364  GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA--PNITRGPLDSTVIDGMSVVL 421
             LQ+     +D G++ C   N AG    ++ + +      P   +     TV +G  V L
Sbjct: 8306 VLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQL 8365

Query: 422  ACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS--DAGTYTCLATN 479
            +C   G+    I W K  R +         F    SG+ ++    ++  D+G Y C A+N
Sbjct: 8366 SCHVQGSEPIRIQWLKAGREIKPSDRCSFSFA---SGTAVLELRDVAKADSGDYVCKASN 8422

Query: 480  SRGVDE---------------ASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR 524
              G D                A+    V  R      PQ   V++ T A+ +  V  DP 
Sbjct: 8423 VAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPI 8482

Query: 525  VTIRYIWEKDGATLGTESHPRIRLDRNG---SLHISQTWSGDIGTYTCRVISAGGNDSRS 581
              ++  W K G         R+ + + G    L I  T   D G Y C   +  G    +
Sbjct: 8483 PNVK--WTK-GKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESN 8539

Query: 582  AHLRV 586
             +L+V
Sbjct: 8540 VNLQV 8544



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 163/705 (23%), Positives = 268/705 (38%), Gaps = 83/705 (11%)

Query: 41    GNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHA-----------GFY 89
             G    L+C   G    + KW    +EL +     +Y ++S  RTH            G Y
Sbjct: 30547 GEAAQLSCQIVGRPLPDIKWYRFGKELIQ---SRKYKMSSDGRTHTLTVMTEEQEDEGVY 30603

Query: 90    RCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASF--PQPQVTW 147
              CI  N +G + +  +++ +     F  G   +   +G         +     P P +TW
Sbjct: 30604 TCIATNEVGEV-ETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTW 30662

Query: 148   FRDGRKIPPSSRIAITLENTLVILSTVAPD------AGRYYVQAVNDKNGDNKTSQPITL 201
             F  G+K+  +S   IT+ENT      V  +      AG+Y VQ  N        +    L
Sbjct: 30663 FH-GQKLLQNSE-NITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFG-----TVDAIL 30715

Query: 202   TVENVGGPADPIAPTIIIPP-KNTSVVA-------GTSEVTLECVANARPLIKLHIIWKK 253
              VE    P  P  P +I    KN++V++       G S +T   V       K    W+ 
Sbjct: 30716 DVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEA--KEGAEWQ- 30772

Query: 254   DGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKE 313
                L+S  IS    R+   N T  +AGYY   +   +  +   +  + + +++ P   ++
Sbjct: 30773 ---LVSSAISVTTCRIV--NLT-ENAGYYFRVSAQNTFGISDPLEVSSVVIIKSP--FEK 30824

Query: 314   PERHITAEMEKVVDIPCQAKGVPPPSI------TWYKDAAVVEVEKLTRF--RQRNDGGL 365
             P       +  V    C     PP S        +Y +    +  K       +  +   
Sbjct: 30825 PGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVTTEEIRETVF 30884

Query: 366   QISGLVPDDTGMFQCFARNAAGEVQTSTYLA-------VTSIAPNITRGPLDSTVIDGMS 418
              +  L+      F+    N  GE + S           V   AP+      +  V    +
Sbjct: 30885 SVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSN 30944

Query: 419   VVLACETSGAPRPAITW-QKGERILASGSVQLPRFTPLESG--SLLISPTHISDAGTYTC 475
               L C+ +G P+P + W ++G+ I+A G     R    + G   L+I+     DA  Y  
Sbjct: 30945 ATLVCKVTGHPKPIVKWYRQGKEIIADGLKY--RIQEFKGGYHQLIIASVTDDDATVYQV 31002

Query: 476   LATNSRGVDEASADLVVWARTRITKPPQDQSV-----IKGTQASMVCGVTHDPRVTIRYI 530
              ATN  G    +A L V    +I  P   + +     ++G   S+    +  P   I   
Sbjct: 31003 RATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVIT-- 31060

Query: 531   WEKDGATLGTESHPRIRLDRNGSLHI--SQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ 588
             W+K    +    H ++ + R+ +  +  +     D G Y     +  G D ++  L V  
Sbjct: 31061 WQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 31120

Query: 589   LPHAPEHPVATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKA 647
             +P  P      +S V R ++NLTWT+P  DG S +  YI+E     A   + +     + 
Sbjct: 31121 VPDPPRG--VKVSDVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRVGQA--RE 31176

Query: 648   TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTA 692
             T  TV  L    SYQFR+ A N  G  + S+ +E     E+   A
Sbjct: 31177 TRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDKTRA 31221



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 155/724 (21%), Positives = 278/724 (38%), Gaps = 106/724 (14%)

Query: 311   VKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG---GLQI 367
             +++  + +T ++ +   + CQ  G P P I WY+     E+ +  +++  +DG    L +
Sbjct: 30535 IRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGK--ELIQSRKYKMSSDGRTHTLTV 30592

Query: 368   SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETS- 426
                  +D G++ C A N  GEV+TS+ L + +        PL       +   L      
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMY 30652

Query: 427   -GAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDE 485
              G P PA+TW  G+++L +        T   +  ++ +    + AG Y    +N  G  +
Sbjct: 30653 IGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVD 30712

Query: 486   ASADLVVWAR-TRITKPPQDQSVIKGTQASMVCGVTHDPRVTI-RYIWEKDGATLGTESH 543
             A  D+ +  +  + T P   ++++K +          D    I  Y+ EK  A  G E  
Sbjct: 30713 AILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAE-- 30770

Query: 544   PRIRLDRNGSLHISQTWSGDIGTYTCRV------------ISAGGNDSRSAHLRVRQL-- 589
                           Q  S  I   TCR+            +SA      S  L V  +  
Sbjct: 30771 -------------WQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVI 30817

Query: 590   -------PHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLA 641
                    P AP  P  T++ V + +  + W  P  DG + +  Y LE  E      + + 
Sbjct: 30818 IKSPFEKPGAPGKP--TITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISVT 30875

Query: 642   SVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPP------Q 695
             + + + T  +VK L+    Y+FR+   N  G+ ++S+ +E ++   + P   P      +
Sbjct: 30876 TEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELR 30935

Query: 696   NVIASGRTNQSIMIQWQPPPESHQNGILKGYI---------IRYCLAGLPVGYQ---FKN 743
             N+    ++N +++ +       H   I+K Y          ++Y +     GY      +
Sbjct: 30936 NLNVRYQSNATLVCK----VTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIAS 30991

Query: 744   ITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEAT 803
             +TD D     +      TN    V+   S  + V +      TL+G+     G VHA   
Sbjct: 30992 VTDDDATVYQVRA----TNQGGSVSGTASLEVEVPAKIHLPKTLEGM-----GAVHALRG 31042

Query: 804   NSTTIRFTWNA-PSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVS--- 859
                +I+  ++  P P           +I W+  Q+    ++    ++Q  +   F S   
Sbjct: 31043 EVVSIKIPFSGKPDP-----------VITWQKGQD----LIDNNGHYQVIVTRSFTSLVF 31087

Query: 860   --GLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQE 917
               G+++    F  V+C        + T +L     DVP P   +  S++   S+ ++W E
Sbjct: 31088 PNGVERKDAGF-YVVCAKNRFGIDQKTVEL--DVADVPDPPRGVKVSDVSRDSVNLTWTE 31144

Query: 918   PGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQ 976
             P    G  +T Y +  E+   T  R           Y V  L   T+Y   V A    G 
Sbjct: 31145 PASDGGSKITNYIV--EKCATTAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGL 31202

Query: 977   GQVS 980
              + S
Sbjct: 31203 SKPS 31206



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 117/518 (22%), Positives = 207/518 (39%), Gaps = 71/518 (13%)

Query: 41   GNRLVLTCMAEGSWPLEFKWLHNNRELTKF-SLEYRYM-------ITSLDRTHAGFYRCI 92
            G  +V  C   GS P+   W  + + L    +++  ++       I   DR+ AG Y C 
Sbjct: 8071 GLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130

Query: 93   VRNRMGALLQRQTEVQVAYMGS--FEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRD 150
              N +G+       +         F+          GE+A        + P  +V+W +D
Sbjct: 8131 ATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPI-KVSWAKD 8189

Query: 151  GRKIPPSSRIAIT-LENT--LVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVG 207
             R+I    +  I+ LEN+  L +L     D+G+Y   AVN+   D+ T+Q   L ++   
Sbjct: 8190 SREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQ---LNIKER- 8245

Query: 208  GPADPIAPTIIIPPKNTSVVAGTSEVT------LEC-VANARPLIKLHIIWKKDGVLLSG 260
                      +IPP  T  ++ T E T      LE  VA ++P+    + W K+ + +  
Sbjct: 8246 ----------LIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPIT---VAWYKNNIEIQ- 8291

Query: 261  GISDHNRRLTIPNPT---------GSDAGYYECEAVLRSSSVPSVVRGAYLSVLEP--PQ 309
                 N  +T  N T          +DAG Y C+    S+   S +  + + + EP  P 
Sbjct: 8292 --PTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKV---SNDAGSALCTSSIVIKEPKKPP 8346

Query: 310  FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG-LQIS 368
               +    +T    + V + C  +G  P  I W K    ++      F   +    L++ 
Sbjct: 8347 VFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELR 8406

Query: 369  GLVPDDTGMFQCFARNAAGEVQTSTYLAVT---SIAPNITRGPLDST-----------VI 414
             +   D+G + C A N AG   T + + +    ++AP   +  +D             V+
Sbjct: 8407 DVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVV 8466

Query: 415  DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYT 474
            +  +     +  G P P + W KG+    +   ++      +   L I  T  +D+G Y 
Sbjct: 8467 EKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYR 8526

Query: 475  CLATNSRGVDEASADLVVWARTRITKPPQD-QSVIKGT 511
            C+A N  G  E++ +L V  R +  K   D ++++K T
Sbjct: 8527 CVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKT 8564



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 113/486 (23%), Positives = 191/486 (39%), Gaps = 71/486 (14%)

Query: 120   KHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLE---NTLVILSTVAP 176
             K  +V+ GE A        S+    V W+  G+K+ PS ++    E   +TL +      
Sbjct: 12203 KDVTVTAGETATFDCE--LSYEDIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 12260

Query: 177   DAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLE 236
             DAG   + A + K   N       L V+          P     P     V   +   LE
Sbjct: 12261 DAGEVQLTAKDFKTHAN-------LFVKE--------PPVEFTKPLEDQTVEEGATAVLE 12305

Query: 237   CVANARPLIKLHIIWKKDGVLLSGG-----ISDHN-RRLTIPNPTGSDAGYYECEAVLRS 290
             C  +        + W K+G  +        ++D   R+L I + T  D   Y C+A    
Sbjct: 12306 CEVSRE---NAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFK 12362

Query: 291   SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVE 350
             +S         L+V+ P      P   +    +++    C+        + W+KD A  E
Sbjct: 12363 TS-------CNLNVVPPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVKWFKDGA--E 12412

Query: 351   VEKLTRFRQRNDGGLQI---SGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG 407
             ++K  ++   + G ++I   +  + DD   + C  R A    +TS  L V       T+ 
Sbjct: 12413 IKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFTKN 12468

Query: 408   PLDSTVIDGMSVVLACETSGAPRPAITWQKG-ERILASGSVQLPRFTPLESGSLLISPTH 466
               +  V +  ++ L CE S  P   + W KG E I+ +G  ++   T      L+I   H
Sbjct: 12469 LANIEVSETDTIKLVCEVS-KPGAEVIWYKGDEEIIETGRYEI--LTEGRKRILVIQNAH 12525

Query: 467   ISDAGTYTCLATNSR-----GVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH 521
             + DAG Y C   +SR      V E +A+ +          PQ+  +++G +A  VC ++ 
Sbjct: 12526 LEDAGNYNCRLPSSRTDGKVKVHELAAEFI--------SKPQNLEILEGEKAEFVCSISK 12577

Query: 522   DPRVTIRYIWEKDGATLGT-ESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSR 580
             +   +    W++D  TL + + +  I   +   L +      D+GTY   V    G    
Sbjct: 12578 E---SFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMV----GAARA 12630

Query: 581   SAHLRV 586
             +AHL V
Sbjct: 12631 AAHLTV 12636



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 101/443 (22%), Positives = 159/443 (35%), Gaps = 77/443 (17%)

Query: 118  GEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTV 174
            G K+ +V  GE+  +    I+ +P P VTW+R+  +I  S    IT ++    L+I    
Sbjct: 948  GLKNVTVIEGESVTLEC-HISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAF 1006

Query: 175  APDAGRYYVQAVNDKNGDNKT-------------------------------SQPITLT- 202
            A D+GR+   AVN+    + +                               S+ + +T 
Sbjct: 1007 AEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTD 1066

Query: 203  ---VENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLS 259
                E   GP +P AP  I  P    +V G S V   C     P  K H+ WKK GV L+
Sbjct: 1067 TSLTEEQAGPGEPAAPYFITKPVVQKLVEGGS-VVFGCQVGGNP--KPHVYWKKSGVPLT 1123

Query: 260  GGIS---DHNR-----RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQF- 310
             G      +N+     +L I      DAG Y    V+R+    +    A  S+LE   + 
Sbjct: 1124 TGYRYKVSYNKQTGECKLVISMTFADDAGEY--TIVVRNKHGET---SASASLLEEADYE 1178

Query: 311  -VKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISG 369
             + + ++ +  + +    +     G   P   + +     E E+    ++     + +  
Sbjct: 1179 LLMKSQQEMLYQTQVTAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRT 1238

Query: 370  LVPDDTGMFQCFARNAAGEVQ---------------TSTYLAVTSIAPNITRGPLDS--- 411
             V D       F      E++                   +AV            DS   
Sbjct: 1239 YVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIK 1298

Query: 412  --TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISD 469
               +++GM V   C+ SG P P I W K  + +  G      F      SL I      D
Sbjct: 1299 NYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPED 1358

Query: 470  AGTYTCLATNSRGVDEASADLVV 492
             G YT  A+N +G    S  L V
Sbjct: 1359 EGIYTAFASNIKGNAICSGKLYV 1381



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 71/269 (26%), Positives = 105/269 (39%), Gaps = 58/269 (21%)

Query: 307  PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG-- 364
            PP  V   +     E E V  + C   G P P++TWY++    ++E    F+     G  
Sbjct: 942  PPTLVSGLKNVTVIEGESVT-LECHISGYPSPTVTWYRED--YQIESSIDFQITFQSGIA 998

Query: 365  -LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV-------------------------- 397
             L I     +D+G F C A N AG V TS YLAV                          
Sbjct: 999  RLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVE 1058

Query: 398  --------TSI-----------APNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKG 438
                    TS+           AP     P+   +++G SVV  C+  G P+P + W+K 
Sbjct: 1059 SRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKS 1118

Query: 439  ERILASGSVQLPRFTPLESG--SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWART 496
               L +G      +   ++G   L+IS T   DAG YT +  N  G   ASA L+  A  
Sbjct: 1119 GVPLTTGYRYKVSYNK-QTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADY 1177

Query: 497  RITKPPQDQSVIKGTQASMVCGVTHDPRV 525
             +    Q + + +    + V     +P+V
Sbjct: 1178 ELLMKSQQEMLYQ----TQVTAFVQEPKV 1202



 Score = 69.3 bits (168), Expect = 4e-11
 Identities = 134/549 (24%), Positives = 214/549 (38%), Gaps = 78/549 (14%)

Query: 897   PVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRIS-WEEYNRTNTRVTHYLPNVTLEYR 954
             P G +    +L  S  +SW+ P +  G  +T Y +   E       ++     +VT   R
Sbjct: 30726 PTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTT-CR 30784

Query: 955   VTGLTALTTYTIEVAAMTSKGQG---QVSASTISSGVPPELPGPPTNLGISNIGPRSVTL 1011
             +  LT    Y   V+A  + G     +VS+  I    P E PG P    I+ +   S  +
Sbjct: 30785 IVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKS-PFEKPGAPGKPTITAVTKDSCVV 30843

Query: 1012  QFRP-GYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFR 1070
              ++P   DG   I  + +E +     +  +W+ +   + E       V +L     Y FR
Sbjct: 30844 AWKPPASDGGAKIRNYYLEKREK---KQNKWISV--TTEEIRETVFSVKNLIEGLEYEFR 30898

Query: 1071  MRQVNIVGTSPPSQPSRKIQTLQAPPDMAP------ANVSLRTASETSLWLRWM--PLPE 1122
             ++  N+ G S  S+ S  I      P  AP       N+++R  S  +L  +    P P 
Sbjct: 30899 VKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPI 30958

Query: 1123  ME-YNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAI 1181
             ++ Y    E +   +KY   +  G     ++    + D T+           QV+A N  
Sbjct: 30959 VKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATV----------YQVRATNQG 31008

Query: 1182  GS--GPWSQTVVGRTRESVPSS--GPTNVSALATTSSSMLVRWSEVPEA----------- 1226
             GS  G  S  V    +  +P +  G   V AL     S+ + +S  P+            
Sbjct: 31009 GSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQKGQDLI 31068

Query: 1227  DRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS 1286
             D NG    Y+V+     +       LV  N     +    G YV     V A  R G   
Sbjct: 31069 DNNG---HYQVIVTRSFTS------LVFPNG---VERKDAGFYV-----VCAKNRFGIDQ 31111

Query: 1287  PSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTAN 1346
              +    +E  + DVP PP G+   +V   SV L W  PA+  G     +IT+ +    A 
Sbjct: 31112 KT----VELDVADVPDPPRGVKVSDVSRDSVNLTWTEPASDGG----SKITNYIVEKCAT 31163

Query: 1347  TATVEVLAPSARQ--YTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPS 1404
             TA   +    AR+  YT   L  ++ Y FR+ A+ + G  + +E    T  K D+    +
Sbjct: 31164 TAERWLRVGQARETRYTVINLFGKTSYQFRVIAENKFGLSKPSEPSEPTITKEDK----T 31219

Query: 1405  RPMVQQEDV 1413
             R M   E+V
Sbjct: 31220 RAMNYDEEV 31228



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 85/414 (20%), Positives = 173/414 (41%), Gaps = 46/414 (11%)

Query: 16    RAARAQDDVSPYFKTEPVRTQVHL-EGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEY 74
             + ++A ++V  + + +   TQ+ + EG RLVL     G+   + KW+ N  ELT  S EY
Sbjct: 33027 KTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGA--TDVKWVLNGVELTN-SEEY 33083

Query: 75    RYMITSLDRT---------HAGFYRCIVRNRMGALLQRQTEV----QVAYMGSFEEGEKH 121
             RY ++  D+T           G   CI + + G +++ Q ++    +++   +F    + 
Sbjct: 33084 RYGVSGSDQTLTIKQASHRDEGILTCISKTKEG-IVKCQYDLTLSKELSDAPAFISQPRS 33142

Query: 122   QSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTVAPDA 178
             Q+++ G+  +     I+  P P++ WF++   I  SS ++I+      +L I +    D+
Sbjct: 33143 QNINEGQNVLFTC-EISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDS 33201

Query: 179   GRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECV 238
             G+Y ++A N +   + T+  + L +       +P    ++    +TS+    S  +++  
Sbjct: 33202 GKYTIKAKNFRGQCSATASLMVLPLVE-----EPSREVVLRTSGDTSLQGSFSSQSVQMS 33256

Query: 239   ANARPL-------IKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSS 291
             A+ +              + +     +S       +   +   + S  G      +  S+
Sbjct: 33257 ASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESST 33316

Query: 292   S--VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV 349
             S  + + +RG       PP+    P   I+ +  KV+ + C   G P P +TW      +
Sbjct: 33317 SKMLKAGIRGI------PPKIEALPS-DISIDEGKVLTVACAFTGEPTPEVTWSCGGRKI 33369

Query: 350   EVEKLTRFRQRNDGGLQ---ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI 400
               ++  RF   N   L    I  +   D G++     N  G    +  + + SI
Sbjct: 33370 HSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRSI 33423



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 107/426 (25%), Positives = 171/426 (40%), Gaps = 45/426 (10%)

Query: 283   ECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEP-ERHITAEMEKVVDIPCQA--KGVPPPS 339
             E EA +   S P+ +    LS+ +P      P + H+T    K + I  +   K    P 
Sbjct: 14261 ENEAGVGHPSEPTEI----LSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPI 14316

Query: 340   ITWYKDAAVVEVEKLTRFRQRNDGGLQIS---GLVPDDTGMFQCFARNAAG-----EVQT 391
             I ++ +   V  EK  R   R    L+     G+VPD   + +  A NA G     E+  
Sbjct: 14317 IGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISE 14376

Query: 392   STYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLP 450
             +         P I     D  VI+G  + +       P P ++W K G+ + AS  + + 
Sbjct: 14377 NVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMK 14436

Query: 451   RFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKG 510
                   S  L +  +  +DAG YT    N  G   AS ++ V     +  P +D      
Sbjct: 14437 N--DHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIG---LPGPCKDIKASDI 14491

Query: 511   TQASMVCGVTHDP------RVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDI 564
             T++S  C +T +P         + Y+ E+  A  G  ++  +    +G   +S T    I
Sbjct: 14492 TKSS--CKLTWEPPEFDGGTPILHYVLERREA--GRRTYIPVM---SGENKLSWTVKDLI 14544

Query: 565   --GTYTCRVISA----GGNDSRSAHLRVRQLPHAPEHPVATLSTVE--RRAINLTWTKP- 615
               G Y  RV +     GG      +  + Q P  P  P   +        A+ +TW  P 
Sbjct: 14545 PNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPL 14604

Query: 616   FDGNSPLIRYILE-MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKG 674
             +DG S ++ YI+E +++    W      + P  T  T KGL   + YQFR+ A N  G  
Sbjct: 14605 YDGGSKIMGYIIEKIAKGEERWKRCNEHLVPILT-YTAKGLEEGKEYQFRVRAENAAGIS 14663

Query: 675   QFSKDT 680
             + S+ T
Sbjct: 14664 EPSRAT 14669



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 75/363 (20%), Positives = 146/363 (40%), Gaps = 33/363 (9%)

Query: 251   WKKDGVLLSG------GISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSV 304
             W  +GV L+       G+S  ++ LTI   +  D G   C     S +   +V+  Y   
Sbjct: 33070 WVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCI----SKTKEGIVKCQYDLT 33125

Query: 305   L-----EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEV-EKLTRFR 358
             L     + P F+ +P      E + V+   C+  G P P I W+K+   + +   ++  R
Sbjct: 33126 LSKELSDAPAFISQPRSQNINEGQNVL-FTCEISGEPSPEIEWFKNNLPISISSNVSISR 33184

Query: 359   QRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL----DSTVI 414
              RN   L+I      D+G +   A+N  G+   +  L V  +    +R  +      T +
Sbjct: 33185 SRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSL 33244

Query: 415   DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYT 474
              G     + + S + + A ++       AS   ++ +F  + + S+        +  + +
Sbjct: 33245 QGSFSSQSVQMSASKQEA-SFSSFSSSSASSMTEM-KFASMSAQSMSSMQESFVEMSSSS 33302

Query: 475   CLATNSRGVDEASADLVVWARTRITKP-----PQDQSVIKGTQASMVCGVTHDPRVTIRY 529
              +  ++    E+S   ++ A  R   P     P D S+ +G   ++ C  T +P  T   
Sbjct: 33303 FMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEP--TPEV 33360

Query: 530   IWEKDGATLGTESHPRIRLDRNG---SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRV 586
              W   G  + ++   R  ++      +L I      D G YT  + +  G+DS + ++ +
Sbjct: 33361 TWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420

Query: 587   RQL 589
             R +
Sbjct: 33421 RSI 33423



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 118/468 (25%), Positives = 185/468 (39%), Gaps = 61/468 (13%)

Query: 122  QSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLEN----TLVILSTVAPD 177
            Q+V  G  A  R  R+   P P+  W+++G KI  S RI           LVI    A D
Sbjct: 2087 QTVGQGSDAHFRV-RVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAED 2145

Query: 178  AGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSE--VTL 235
            +    V+A+N      +TS    L V+            I    +   VVA   +   T 
Sbjct: 2146 SASIMVKAINIA---GETSSHAFLLVQ--------AKQLITFTQELQDVVAKEKDTMATF 2194

Query: 236  ECVANARPLIKLHIIWKKDGVLLSGG--ISDHNRR----LTIPNPTGSDAGYYECEAVLR 289
            EC   + P +K  + W KDG+ +  G     H+ R    L+I     SDA  Y C  V  
Sbjct: 2195 EC-ETSEPFVK--VKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVED 2251

Query: 290  ---SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWY-KD 345
                ++   +V GA +  ++  Q ++ PE + + E+E +V  P   +G       WY  D
Sbjct: 2252 ENVKTTAKLIVEGAVVEFVKELQDIEVPESY-SGELECIVS-PENIEG------KWYHND 2303

Query: 346  AAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT 405
              +    K T   +R    L +  +  +D G +           +T+  L +      I 
Sbjct: 2304 VELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGK----KTTCKLKMKPRPIAIL 2359

Query: 406  RGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT 465
            +G  D  V +G  V L  + S      +  + G+ +  S  V +      +S  LLI   
Sbjct: 2360 QGLSDQKVCEGDIVQLEVKVSLESVEGVWMKDGQEVQPSDRVHI--VIDKQSHMLLIEDM 2417

Query: 466  HISDAGTYTC------LATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGV 519
               DAG Y+       L+T+ R V   S D++         P +D +VI+GT+A + C V
Sbjct: 2418 TKEDAGNYSFTIPALGLSTSGR-VSVYSVDVIT--------PLKDVNVIEGTKAVLECKV 2468

Query: 520  THDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTY 567
            +  P VT    +  D      +    I       L I++T + D G Y
Sbjct: 2469 S-VPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2515



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 89/345 (25%), Positives = 132/345 (38%), Gaps = 38/345 (11%)

Query: 268  RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVD 327
            RL IP+   SDAG Y   A    S+    V G  + +    + +K+ E  +  +   VV+
Sbjct: 3113 RLLIPSTRMSDAGKYTVVAGGNVSTAKLFVEGRDVRI----RSIKK-EVQVIEKQRAVVE 3167

Query: 328  IPCQAKGVPPPSITWYKDAAVVEVEKLTRFR---QRNDGGLQISGLVPDDTGMFQCFARN 384
                   V      WYKD   +  +   R +   +R    + IS     D G +      
Sbjct: 3168 FEVNEDDV---DAHWYKDGIEINFQVQERHKYVVERRIHRMFISETRQSDAGEYTF---- 3220

Query: 385  AAGEVQTSTYLAVTSIAPNITRGPLDS-TVIDGMSVVLACETSGAPRPAITWQKGERILA 443
             AG  ++S  L V +  P      L   TV  G         SG P+P I+W K E++L+
Sbjct: 3221 VAGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLS 3280

Query: 444  SGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWA--------- 494
            +G  +       +  +LL+      DA  YTC A N  GV   SA L V           
Sbjct: 3281 TG-FKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQE 3339

Query: 495  ----RTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIW-EKDGATLGTESHPRIRLD 549
                   I  P QD    +G  A   C V+      ++  W  KD     +      + +
Sbjct: 3340 MPVYPPAIITPLQDTVTSEGQPARFQCRVS---GTDLKVSWYSKDKKIKPSRFFRMTQFE 3396

Query: 550  RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPE 594
                L I++ +  D GTYT    +A G  S +A+L +     APE
Sbjct: 3397 DTYQLEIAEAYPEDEGTYTFVASNAVGQVSSTANLSL----EAPE 3437



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 103/471 (21%), Positives = 164/471 (34%), Gaps = 106/471 (22%)

Query: 141   PQPQVTWFRDGRKIPPSSRIAITL---ENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQ 197
             P P VTW R G+ +  S+R  +T    ++T  I S  A D G Y V     +N + K   
Sbjct: 32588 PVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVV---ENSEGKQEA 32644

Query: 198   PITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVL 257
               TLT++     A      +  PP+               V +  P +K     K     
Sbjct: 32645 EFTLTIQK----ARVTEKAVTSPPR---------------VKSPEPRVKSPEAVKSP--- 32682

Query: 258   LSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGA-YLSVLEPPQFVKEPER 316
                      +R+  P P+         +AV  + + P+      +L V  PP+  +  + 
Sbjct: 32683 ---------KRVKSPEPSHP-------KAVSPTETKPTPTEKVQHLPVSAPPKITQFLKA 32726

Query: 317   HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG--LQISGLVPDD 374
               + E+ K+  +  ++  +    +TWYKD   ++     +F    DG   L+I+ L   D
Sbjct: 32727 EASKEIAKLTCV-VESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESD 32785

Query: 375   TGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT 434
              G +                                            CE SG       
Sbjct: 32786 QGEY-------------------------------------------VCEISG------- 32795

Query: 435   WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWA 494
               +G     +       F  +      IS T  SD  T     T      E  A   + +
Sbjct: 32796 --EGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKT---EPKAPEPISS 32850

Query: 495   RTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGS- 553
             +  I    QD +V   + A      T +PR T   IW KDG  +      ++  D+ G  
Sbjct: 32851 KPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTA--IWTKDGKAITQGGKYKLSEDKGGFF 32908

Query: 554   LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVE 604
             L I +T + D G YTC V ++ G+ S S  L ++ +       V+T  T E
Sbjct: 32909 LEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSE 32959



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 47/165 (28%), Positives = 78/165 (47%), Gaps = 8/165 (4%)

Query: 334 GVPPPSITWYKDAAVVEVEKLTRFRQRNDGG---LQISGLVPDDTGMFQCFARNAAGEVQ 390
           G P P ++W++D  V+    L   +     G   L I  +   ++G +   A N +G+  
Sbjct: 31  GFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYSLKATNGSGQAT 90

Query: 391 TSTYLAVTS--IAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSV 447
           ++  L V +    PN  +     TV  G  V L    +G P P + + + G  I +S   
Sbjct: 91  STAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDF 150

Query: 448 QLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 492
           Q+ +   L S  LLI+  +  D+GTY+  ATNS G   ++A+L+V
Sbjct: 151 QISQEGDLYS--LLIAEAYPEDSGTYSVNATNSVGRATSTAELLV 193



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 51/212 (24%), Positives = 104/212 (49%), Gaps = 13/212 (6%)

Query: 397 VTSIAPNITRGPLDSTVI-DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPL 455
           +T+ AP  T+ PL S V+ +G +       SG P P ++W +  +++++ ++   + +  
Sbjct: 1   MTTQAPTFTQ-PLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFS 59

Query: 456 ESGSLLISPTHI-SDAGTYTCLATNSRGVDEASADLVVWART---RITKPPQDQSVIKGT 511
           +  + L  P    +++G Y+  ATN  G   ++A+L+V A T      +  Q  +V +G+
Sbjct: 60  DGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGS 119

Query: 512 QASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLH---ISQTWSGDIGTYT 568
           Q  +   VT  P   +++   +DGA +  +S    ++ + G L+   I++ +  D GTY+
Sbjct: 120 QVRLQVRVTGIPTPVVKFY--RDGAEI--QSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175

Query: 569 CRVISAGGNDSRSAHLRVRQLPHAPEHPVATL 600
               ++ G  + +A L V+     P     T+
Sbjct: 176 VNATNSVGRATSTAELLVQGEEEVPAKKTKTI 207



 Score = 62.0 bits (149), Expect = 6e-09
 Identities = 50/193 (25%), Positives = 85/193 (44%), Gaps = 13/193 (6%)

Query: 214 APTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGG--------ISDH 265
           APT   P ++  V+ G S  T E   +  P+ +  + W +DG ++S           SD 
Sbjct: 5   APTFTQPLQSVVVLEG-STATFEAHISGFPVPE--VSWFRDGQVISTSTLPGVQISFSDG 61

Query: 266 NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKV 325
             +LTIP  T +++G Y  +A   S    S       +   PP FV+  +  +T      
Sbjct: 62  RAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQ-SMTVRQGSQ 120

Query: 326 VDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRND-GGLQISGLVPDDTGMFQCFARN 384
           V +  +  G+P P + +Y+D A ++     +  Q  D   L I+   P+D+G +   A N
Sbjct: 121 VRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180

Query: 385 AAGEVQTSTYLAV 397
           + G   ++  L V
Sbjct: 181 SVGRATSTAELLV 193



 Score = 61.6 bits (148), Expect = 8e-09
 Identities = 73/294 (24%), Positives = 108/294 (36%), Gaps = 64/294 (21%)

Query: 343  YKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA- 401
            YK  A VEV+K        + G+ I+G    +   F+      A   +T+   A   I  
Sbjct: 890  YKSEAGVEVKK--------EVGVSITGTTVREE-RFEVLHGREAKVTETARVPAPVEIPV 940

Query: 402  --PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS 459
              P +  G  + TVI+G SV L C  SG P P +TW + +  + S S+            
Sbjct: 941  TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIES-SIDFQITFQSGIAR 999

Query: 460  LLISPTHISDAGTYTCLATNSRGVDEASADL----------------------------- 490
            L+I      D+G +TC A N  G    S  L                             
Sbjct: 1000 LMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVES 1059

Query: 491  --VVWARTRITK---------------PPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEK 533
              VV   T +T+                P  Q +++G      C V  +P+  +   W+K
Sbjct: 1060 RDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHV--YWKK 1117

Query: 534  DGATLGTESHPRIRLDRNG---SLHISQTWSGDIGTYTCRVISAGGNDSRSAHL 584
             G  L T    ++  ++      L IS T++ D G YT  V +  G  S SA L
Sbjct: 1118 SGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 73/277 (26%), Positives = 111/277 (40%), Gaps = 21/277 (7%)

Query: 307   PPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSI--TWYKDAAVVEVEKLTRF-RQRNDG 363
             P +FVKE +  I  E E V         V P +   TW KD + +      RF     D 
Sbjct: 11114 PLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITTWMKDGSNIRESPKHRFIADGKDR 11173

Query: 364   GLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDS-TVIDGMSVVLA 422
              L I  +   D G + C  R    E  ++  L V  +     +   +  TV+ G  + L+
Sbjct: 11174 KLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 11233

Query: 423   CETSGAPRPAITWQKGERILASGSVQLP-RFTPLESG---SLLISPTHISDAGTYTCLAT 478
             CE +      + W+K  +I+    V+ P R  P   G   +L I+    +DAGTYT    
Sbjct: 11234 CELN--KERDVVWRKDGKIV----VEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVE 11287

Query: 479   NSRGVDEASADLVVWA-RTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGAT 537
             N+  ++ +S   VV   R  + KP +DQ V     A   C +  D   T    W K    
Sbjct: 11288 NANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIAKD---TPNIKWFKGYDE 11344

Query: 538   LGTESHPRIRLDRNGS---LHISQTWSGDIGTYTCRV 571
             +  E + +  + R+G+   L I      DI  Y   +
Sbjct: 11345 IPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEYAVEI 11381



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 119/615 (19%), Positives = 209/615 (33%), Gaps = 95/615 (15%)

Query: 22   DDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSL 81
            +  +PYF T+PV  Q  +EG  +V  C   G+      W  +   LT     YRY ++  
Sbjct: 1078 EPAAPYFITKPV-VQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTT---GYRYKVSYN 1133

Query: 82   DRT-------------HAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGE 128
             +T              AG Y  +VRN+ G      + ++ A      + ++        
Sbjct: 1134 KQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYELLMKSQQEMLYQTQV 1193

Query: 129  AAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVND 188
             A ++ P++       V    +       + I   +    V++ T   D   +++ +  +
Sbjct: 1194 TAFVQEPKVGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVVVRTYVEDQ-EFHISSFEE 1252

Query: 189  KNGDNKTSQPITLTVENVG------------GPADPIAPTIIIPPKNTSVVAGTSEVTLE 236
            +       + I  T+E +               ++ +        KN  ++ G   VT  
Sbjct: 1253 RLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMG-VTFH 1311

Query: 237  CVANARPLIKLHIIWKKDGVLLSGG-------ISDHNRRLTIPNPTGSDAGYYECEAVLR 289
            C  +  PL K  I W KDG  +  G       + D    L IP     D G Y   A   
Sbjct: 1312 CKMSGYPLPK--IAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFA--- 1366

Query: 290  SSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV 349
                 S ++G  +                           C  K    P+        + 
Sbjct: 1367 -----SNIKGNAI---------------------------CSGKLYVEPAAPLGAPTYIP 1394

Query: 350  EVEKLTRFRQRNDGGLQISGLVPDDTGMFQCF---ARNAAGEVQTSTYLAVTSIA----- 401
             +E ++R R  +   +  S +      M       AR +   +     L  T  +     
Sbjct: 1395 TLEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERL 1454

Query: 402  --PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGS 459
              P     P+    ++G +     +  G P P   W    + + +            + S
Sbjct: 1455 YKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQS 1514

Query: 460  LLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPP-----QDQSVIKGTQAS 514
            L+I P   SD+G +T +A N  G    S  L V A     KP      ++ ++ +G++  
Sbjct: 1515 LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLE 1574

Query: 515  MVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD---RNGSLHISQTWSGDIGTYTCRV 571
            M    T +P   I  +W K+   +    +P+IR++      +L I  T S D   YT   
Sbjct: 1575 MKVRATGNPNPDI--VWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATA 1632

Query: 572  ISAGGNDSRSAHLRV 586
            I+  G D+    + V
Sbjct: 1633 INKAGRDTTRCKVNV 1647



 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 63/252 (25%), Positives = 95/252 (37%), Gaps = 21/252 (8%)

Query: 262   ISDHNRRLTIPNPTGSDAGYYEC---------EAVLRSSSVPSVVRGAYLSVLEPPQFVK 312
             + D   R  + N  G D+ Y E          +   R +      R   + +LE P    
Sbjct: 31634 LDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFT 31693

Query: 313   EPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEV-EKLTRFRQRNDGGLQ---IS 368
              P  + TA + + V         P P +TWYK    ++  +   ++   +D GL    I+
Sbjct: 31694 LPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTIN 31753

Query: 369   GLVPDDTGMFQCFARNAAGEVQTSTYLAVT--------SIAPNITRGPLDSTVIDGMSVV 420
              +  DD   +   ARN  GE      L VT        ++ P   R   ++   +G SV 
Sbjct: 31754 SVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVC 31813

Query: 421   LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480
                  SG P P + W+K  + L+ G         L+  +L I  T   D G Y   ATN+
Sbjct: 31814 FEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNT 31873

Query: 481   RGVDEASADLVV 492
              G     A L V
Sbjct: 31874 AGSTSCQAHLQV 31885



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 84/361 (23%), Positives = 124/361 (34%), Gaps = 62/361 (17%)

Query: 279   AGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPP 338
             A    C   +RS    SV +    S+   P  V     H   E    V   C+ +     
Sbjct: 31540 AARISCGGAIRSQKGVSVAKVKVASIEIGP--VSGQIMHAVGEEGGHVKYVCKIENYDQS 31597

Query: 339   S-ITWYKDAAVVEVEKLTRFRQRNDGG---LQISGLVPDDTGMFQCFARNAAGEVQTSTY 394
             + +TWY    V ++E   ++    + G   L +  +   D G ++C   N  GE  +   
Sbjct: 31598 TQVTWY--FGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAE 31655

Query: 395   LAVTSIA---------------------------PNITRGPLDSTVIDGMSVVLACETSG 427
             L V  +                            P  T    + T   G +V      + 
Sbjct: 31656 LFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITV 31715

Query: 428   APRPAITWQKGERILASGSVQLPRFTPLESG--SLLISPTHISDAGTYTCLATNSRGVDE 485
              P P +TW K  + +  G          + G   L I+     D   YT +A N  G D 
Sbjct: 31716 HPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDS 31775

Query: 486   ASADLVVWARTRITKPPQDQSV---IKGTQASMVCG----------VTHDPRVTIRYIWE 532
               A L V     +  PP D ++    K   A+  C           V+  P  T++  WE
Sbjct: 31776 CKAKLTV----TLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLK--WE 31829

Query: 533   KDGATLGTESHPRIRLDRNG----SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQ 588
             KDG  L     P I +   G    +LHI  T   D G Y     +  G+ S  AHL+V +
Sbjct: 31830 KDGQPLSLG--PNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVER 31887

Query: 589   L 589
             L
Sbjct: 31888 L 31888



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 36/123 (29%), Positives = 59/123 (47%), Gaps = 5/123 (4%)

Query: 388   EVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSV 447
             E +++T    T++A  I   P   TV +G S   +C+T G P P +TW +  ++L++ + 
Sbjct: 32547 EEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSAR 32606

Query: 448   QLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW----ARTRITKPPQ 503
                  T  +S +  IS    SD G Y+ +  NS G  EA   L +         +T PP+
Sbjct: 32607 HQVTTTKYKS-TFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPR 32665

Query: 504   DQS 506
              +S
Sbjct: 32666 VKS 32668



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 90/391 (23%), Positives = 145/391 (37%), Gaps = 54/391 (13%)

Query: 56    LEFKWLHNN--RELTKF--SLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAY 111
             L+  WL     R  TK   +L++R    +L +          R   G  ++ Q  V VA 
Sbjct: 31500 LQHPWLKQKIERVSTKVIRTLKHRRYYHTLIKKDLNMVVSAARISCGGAIRSQKGVSVAK 31559

Query: 112   M--GSFEEGEKHQSVSH--GEAA--VIRAPRIASFPQP-QVTWFRDGRKIPPSSRIAITL 164
             +   S E G     + H  GE    V    +I ++ Q  QVTW+   R++  S +  IT 
Sbjct: 31560 VKVASIEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITY 31619

Query: 165   ENTLVIL---STVAPDAGRYYVQAVNDKNGDNKTSQPIT------------LTVENVGGP 209
             E+ + IL        D G Y  + VND   D+  ++                T++ +   
Sbjct: 31620 EDGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRR 31679

Query: 210   ADPI-----APTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISD 264
              D +      P   +P  N +   G   V         P  + H+ W K G  +  G +D
Sbjct: 31680 TDTMRLLERPPEFTLPLYNKTAYVG-ENVRFGVTITVHP--EPHVTWYKSGQKIKPGDND 31736

Query: 265   HN---------RRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP---QFVK 312
                         +LTI + T  D   Y    V R+       +      L PP     ++
Sbjct: 31737 KKYTFESDKGLYQLTINSVTTDDDAEY--TVVARNKYGEDSCKAKLTVTLHPPPTDSTLR 31794

Query: 313   EPERHITAEME----KVVDIPCQAKGVPPPSITWYKDAAVVEV-EKLTRFRQRND-GGLQ 366
                + + A  E    + V    +  G+PPP++ W KD   + +   +    +  D   L 
Sbjct: 31795 PMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALH 31854

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQTSTYLAV 397
             I   +P+DTG ++  A N AG      +L V
Sbjct: 31855 IRDTLPEDTGYYRVTATNTAGSTSCQAHLQV 31885



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 129/618 (20%), Positives = 223/618 (36%), Gaps = 82/618 (13%)

Query: 24   VSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFS---LEYR----- 75
            + P F      T    EGN   L     GS P+   W  NN E+   S   + ++     
Sbjct: 8247 IPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLV 8306

Query: 76   YMITSLDRTHAGFYRCIVRNRMGALLQRQTEV--QVAYMGSFEEGEKHQSVSHGEAAVIR 133
              +       AG Y C V N  G+ L   + V  +      F++     +VS GE   + 
Sbjct: 8307 LQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLS 8366

Query: 134  APRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVIL---STVAPDAGRYYVQAVNDKN 190
                 S P  ++ W + GR+I PS R + +  +   +L        D+G Y  +A N   
Sbjct: 8367 CHVQGSEP-IRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASN-VA 8424

Query: 191  GDNKTSQPITLTVENVGGPADPIAPT-----IIIPPKNTSVVAGTSEVTLECVANARPLI 245
            G + T   +T+  +    PA   A        +  P++  VV  T+  T        P+ 
Sbjct: 8425 GSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTT-ATFIAKVGGDPIP 8483

Query: 246  KLHIIWKKDGVLLSGG-ISDHNR----RLTIPNPTGSDAGYYECEAVLRSSSVPS----- 295
             +     K   L  GG +  H +    +L I + T +D+G Y C A      + S     
Sbjct: 8484 NVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543

Query: 296  --------VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
                     + G   ++L+    +K+      A  E+ +DI    K V P     Y    
Sbjct: 8544 VDERKKQEKIEGDLRAMLKKTPILKK-----GAGEEEEIDIMELLKNVDPKEYEKY---- 8594

Query: 348  VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQC--FARNAAGEVQTSTYLA-----VTSI 400
               +  +T FR        +     ++T   +     R+   E +    ++     ++  
Sbjct: 8595 -ARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQT 8653

Query: 401  AP-NITRGPLDSTVIDGMSVVLACETS-GAPRPAITWQKG-ERILASGSVQLPRFTPLES 457
             P  + +   + TV+     V   +     P   ++W KG E++  S   ++      + 
Sbjct: 8654 EPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPSDKFEIS--IDGDR 8711

Query: 458  GSLLISPTHISDAGTYTCLATNSRGVDEASADLVV----WARTRITKPPQDQSVIKGTQA 513
             +L +    + D G Y  +     G   ASA L V    W R       QD ++ +G   
Sbjct: 8712 HTLRVKNCQLKDQGNYRLVC----GPHIASAKLTVIEPAWERHL-----QDVTLKEGQTC 8762

Query: 514  SMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQTWSGDIGTYTCRVI 572
            +M C  +      ++  W ++G  L  +   +  ++     L I+   + D G YTC+  
Sbjct: 8763 TMTCQFSVP---NVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYE 8819

Query: 573  SAGGNDSRSAHLRVRQLP 590
                    SA LR+   P
Sbjct: 8820 DL----ETSAELRIEAEP 8833



 Score = 55.5 bits (132), Expect = 6e-07
 Identities = 62/224 (27%), Positives = 93/224 (41%), Gaps = 25/224 (11%)

Query: 1721  QAAPSAPSS-VKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVS-KIVTVD 1777
             Q  P  P+  +    L   S  +SW+ P    G  +  Y  V E C   +G   ++V+  
Sbjct: 30720 QDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNY--VVEKCEAKEGAEWQLVSSA 30777

Query: 1778  VKGNSPLWLKVKDLAEGVTYRFRIRAK-TFTYGPEIEAN---VTTGPGE--GAPGPPGVP 1831
             +   S    ++ +L E   Y FR+ A+ TF     +E +   +   P E  GAPG P + 
Sbjct: 30778 I---SVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTIT 30834

Query: 1832  IIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILK 1891
              + + S  +A    + D G   I  Y +E R   +  W   I    +E+    FS+  L 
Sbjct: 30835 AVTKDSCVVAWKPPASDGG-AKIRNYYLEKREKKQNKW---ISVTTEEIRETVFSVKNLI 30890

Query: 1892  PGVSYDFRVIAVNDYG------FGTPSSPSQSVPAQKANPFYEE 1929
              G+ Y+FRV   N  G         P +P   VP Q A  F EE
Sbjct: 30891 EGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQ-APHFKEE 30933



 Score = 55.1 bits (131), Expect = 7e-07
 Identities = 128/600 (21%), Positives = 208/600 (34%), Gaps = 102/600 (17%)

Query: 23    DVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELT---KFSLEYRYM-- 77
             +  PYF T  +  +  +E + + L C      P+  KW  +  E+    K+S++   +  
Sbjct: 11660 EADPYF-TVKLHDKTAVEKDEITLKCEVSKDVPV--KWFKDGEEIVPSPKYSIKADGLRR 11716

Query: 78    ---ITSLDRTHAGFYRCIV---RNRMGALLQRQ----------TEVQVAYMGSFEEGEKH 121
                I   D    G Y C     + +    ++ +           EV V     FE     
Sbjct: 11717 ILKIKKADLKDKGEYVCDCGTDKTKANVTVEARLIKVEKPLYGVEVFVGETAHFEIELSE 11776

Query: 122   QSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRY 181
               V HG+  +   P  AS   P      DG+K            + L++ +      G  
Sbjct: 11777 PDV-HGQWKLKGQPLTAS---PDCEIIEDGKK------------HILILHNCQLGMTGEV 11820

Query: 182   YVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANA 241
               QA N K+  N       L V+ +        P I I P +   V    E   EC  + 
Sbjct: 11821 SFQAANAKSAAN-------LKVKEL--------PLIFITPLSDVKVFEKDEAKFECEVSR 11865

Query: 242   RPLIKLHIIWKKDGVLLSGG-----ISDHNRR-LTIPNPTGSDAGYYECEAVLRSSSVPS 295
              P       W K    ++G      I D  +  + I +    D   Y  EA  + +S   
Sbjct: 11866 EPKT---FRWLKGTQEITGDDRFELIKDGTKHSMVIKSAAFEDEAKYMFEAEDKHTSGKL 11922

Query: 296   VVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYK-DAAVVEVEKL 354
             ++ G  L  L P + V   E+        V  +      +    + W+K D  +     +
Sbjct: 11923 IIEGIRLKFLTPLKDVTAKEKE-----SAVFTVELSHDNI---RVKWFKNDQRLHTTRSV 11974

Query: 355   TRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVI 414
             +   +     +    L  DDT   +  A   + E +    L V    P  T    D T +
Sbjct: 11975 SMQDEGKTHSITFKDLSIDDTSQIRVEAMGMSSEAK----LTVLEGDPYFTGKLQDYTGV 12030

Query: 415   DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYT 474
             +   V+L CE S A  P   ++ G+ I  S +  +      +   L++     SD G YT
Sbjct: 12031 EKDEVILQCEISKADAPVKWFKDGKEIKPSKNAVIK--ADGKKRMLILKKALKSDIGQYT 12088

Query: 475   CLATNSRGVDEASADLVVWAR-TRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEK 533
             C      G D+ S  L +  R  ++ +P     V++   A     ++ D    I   W+ 
Sbjct: 12089 C----DCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISED---DIHANWKL 12141

Query: 534   DGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGG------NDSRSAHLRVR 587
              G  L     P   +   G +H        +  + CR+   GG      N   SAHLRV+
Sbjct: 12142 KGEAL--LQTPDCEIKEEGKIH-------SLVLHNCRLDQTGGVDFQAANVKSSAHLRVK 12192



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 91/439 (20%), Positives = 152/439 (34%), Gaps = 53/439 (12%)

Query: 92   IVRNRMGALLQRQTEVQVAY--------MGSFEEGEKHQSVSHGEAAVIRAPRIASFPQP 143
            I++  +  LL+   E ++A            F+   K+  +  G        +++ +P P
Sbjct: 1262 IIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILEGMGVTFHC-KMSGYPLP 1320

Query: 144  QVTWFRDGRKIPPSSRIAITL----ENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPI 199
            ++ W++DG++I    R  +        +L I   +  D G Y   A N K     + +  
Sbjct: 1321 KIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGK-- 1378

Query: 200  TLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLS 259
             L VE    PA P+     IP             TLE V+  R L    +   +  + +S
Sbjct: 1379 -LYVE----PAAPLGAPTYIP-------------TLEPVSRIRSLSPRSV--SRSPIRMS 1418

Query: 260  GGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHIT 319
                   R     +P             L  +    + R      L  P FV +P     
Sbjct: 1419 PARMSPARM----SPARMSPARMSPGRRLEETDESQLER------LYKPVFVLKPVSFKC 1468

Query: 320  AEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG--GLQISGLVPDDTGM 377
             E +       +  G P P   W+ D   +  +   +   + DG   L I    P D+G 
Sbjct: 1469 LEGQ-TARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGE 1527

Query: 378  FQCFARNAAGEVQTSTYLAVTSIA----PNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
            +   A+N AG    S  L V ++     P       +  + +G  + +    +G P P I
Sbjct: 1528 WTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDI 1587

Query: 434  TWQKGERILASGSVQLPRFTPLES-GSLLISPTHISDAGTYTCLATNSRGVDEASADLVV 492
             W K   I+        R    +   +L I  T   D+  YT  A N  G D     + V
Sbjct: 1588 VWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNV 1647

Query: 493  WARTRITKPPQDQSVIKGT 511
                   +P +   + +GT
Sbjct: 1648 EVEFAEPEPERKLIIPRGT 1666



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 85/398 (21%), Positives = 146/398 (36%), Gaps = 47/398 (11%)

Query: 221   PKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGG-----ISDHNRRLTIPNPT 275
             P     V    +   ECV       + ++IW K   ++        I+D  + + + N +
Sbjct: 11491 PLKDVTVPERRQARFECVLTR----EANVIWSKGPDIIKSSDKFDIIADGKKHILVINDS 11546

Query: 276   G-SDAGYYECEAVLRSSSVPSVVRGAYLSVLEP--PQFVKEPERHITAEMEKVVDIPCQA 332
                D G Y  E   + +S    V G  L  + P   Q VKE E              C+ 
Sbjct: 11547 QFDDEGVYTAEVEGKKTSARLFVTGIRLKFMSPLEDQTVKEGE---------TATFVCEL 11597

Query: 333   KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGG-LQISGLVPDDTGMFQCFARNAAGEVQT 391
                    + W+K+ A +   +            L++  +  DD    +   +    E+ +
Sbjct: 11598 SH-EKMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVK----ELSS 11652

Query: 392   STYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPR 451
             +  L V    P  T    D T ++   + L CE S    P   ++ GE I+ S     P+
Sbjct: 11653 TAQLKVLEADPYFTVKLHDKTAVEKDEITLKCEVS-KDVPVKWFKDGEEIVPS-----PK 11706

Query: 452   FTPLESG---SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWAR-TRITKPPQDQSV 507
             ++    G    L I    + D G Y C      G D+  A++ V AR  ++ KP     V
Sbjct: 11707 YSIKADGLRRILKIKKADLKDKGEYVC----DCGTDKTKANVTVEARLIKVEKPLYGVEV 11762

Query: 508   IKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTY 567
               G  A     ++      +   W+  G  L   + P   +  +G  HI    +  +G  
Sbjct: 11763 FVGETAHFEIELSEP---DVHGQWKLKGQPL--TASPDCEIIEDGKKHILILHNCQLG-M 11816

Query: 568   TCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVER 605
             T  V     N   +A+L+V++LP     P++ +   E+
Sbjct: 11817 TGEVSFQAANAKSAANLKVKELPLIFITPLSDVKVFEK 11854



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 97/442 (21%), Positives = 163/442 (36%), Gaps = 51/442 (11%)

Query: 145   VTWFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITL 201
             V WF+DG++I PS    I  +     L++   +  D G+Y         G +KTS  + +
Sbjct: 12048 VKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDC-----GTDKTSGKLDI 12102

Query: 202   TVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLL--- 258
                 +      + P   +    T      +E++ +          +H  WK  G  L   
Sbjct: 12103 EDREI----KLVRPLHSVEVMETETARFETEISED---------DIHANWKLKGEALLQT 12149

Query: 259   -SGGISDHNR--RLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPE 315
                 I +  +   L + N      G  + +A    SS    V+   + +L P + V    
Sbjct: 12150 PDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAANVKSSAHLRVKPRVIGLLRPLKDVT--- 12206

Query: 316   RHITAEMEKVVDIPCQAKGVPPPSITWY-KDAAVVEVEKLTRFRQRNDGGLQISGLVPDD 374
               +TA      D     + +P   + WY K   +   +K+    +     L +  +  +D
Sbjct: 12207 --VTAGETATFDCELSYEDIP---VEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLED 12261

Query: 375   TGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT 434
              G  Q  A+    + +T   L V       T+   D TV +G + VL CE S        
Sbjct: 12262 AGEVQLTAK----DFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKW 12317

Query: 435   WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADL-VVW 493
             ++ G  IL S   ++     +    L+I      D  TYTC A + +     S +L VV 
Sbjct: 12318 FKNGTEILKSKKYEIVADGRVR--KLVIHDCTPEDIKTYTCDAKDFK----TSCNLNVVP 12371

Query: 494   ARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT-ESHPRIRLDRNG 552
                   +P  D  V +   A   C ++   R   +  W KDGA +   + +  I      
Sbjct: 12372 PHVEFLRPLTDLQVREKEMARFECELS---RENAKVKWFKDGAEIKKGKKYDIISKGAVR 12428

Query: 553   SLHISQTWSGDIGTYTCRVISA 574
              L I++    D   Y+C V +A
Sbjct: 12429 ILVINKCLLDDEAEYSCEVRTA 12450



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 68/294 (23%), Positives = 106/294 (36%), Gaps = 43/294 (14%)

Query: 326  VDIPCQAKGVPPPSITWYKDAAVVEVEKLTR--FRQRNDGGLQISGLVPDDTGMFQCFAR 383
            V   C+  G P P I WYKD   ++  +  +  F Q     L+I  ++P+D G++  FA 
Sbjct: 1308 VTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTAFAS 1367

Query: 384  NAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILA 443
            N  G    S  L V   AP                        GAP    T +   RI +
Sbjct: 1368 NIKGNAICSGKLYVEPAAP-----------------------LGAPTYIPTLEPVSRIRS 1404

Query: 444  SGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKP-- 501
                 + R +P+      +SP  +S A       +  R ++E     +     R+ KP  
Sbjct: 1405 LSPRSVSR-SPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQL----ERLYKPVF 1459

Query: 502  ---PQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNG--SLHI 556
               P     ++G  A     V   P       W  DG  +  +   ++ +  +G  SL I
Sbjct: 1460 VLKPVSFKCLEGQTARFDLKVVGRPMP--ETFWFHDGQQIVNDYTHKVVIKEDGTQSLII 1517

Query: 557  SQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINL 610
                  D G +T    +  G  S S  L V     A EH V  +   + + +N+
Sbjct: 1518 VPATPSDSGEWTVVAQNRAGRSSISVILTV----EAVEHQVKPMFVEKLKNVNI 1567



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 104/471 (22%), Positives = 175/471 (37%), Gaps = 66/471 (14%)

Query: 113  GSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLE---NTLV 169
            G+  +    Q+V+  + AV       + P  +  W RDG+ +P ++ I    +     L+
Sbjct: 2620 GAISKPLTDQTVAESQEAVFECE--VANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLI 2677

Query: 170  ILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAG 229
            I +T   D G Y  +    K           L VE V      I  T+    KN +V   
Sbjct: 2678 IAATKLDDIGEYTYKVATSKTS-------AKLKVEAV-----KIKKTL----KNLTVT-- 2719

Query: 230  TSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLR 289
             ++  +  V    P +K  + W K+GV+L     + N +  I     S  G      +  
Sbjct: 2720 ETQDAVFTVELTHPNVK-GVQWIKNGVVL-----ESNEKYAI-----SVKGTIYSLRIKN 2768

Query: 290  SSSVPSVVRGAYLSVL--------EPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSIT 341
             + V   V G  L  L        E  + +K+P + +TA     V           P   
Sbjct: 2769 CAIVDESVYGFRLGRLGASARLHVETVKIIKKP-KDVTALENATVAFEVSVSHDTVPVKW 2827

Query: 342  WYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA 401
            ++K   +   +K     +R    L +  + P D G +        G+++    L V ++ 
Sbjct: 2828 FHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTA----VVGQLECKAKLFVETL- 2882

Query: 402  PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461
             +IT+   +  V +  +    CE S    P++  + G  I  S   ++     L    L+
Sbjct: 2883 -HITKTMKNIEVPETKTASFECEVSHFNVPSMWLKNGVEIEMSEKFKIVVQGKLH--QLI 2939

Query: 462  ISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH 521
            I  T   D+  YT +  N    D+ SA L V        P    S++K   A     +T 
Sbjct: 2940 IMNTSTEDSAEYTFVCGN----DQVSATLTV-------TPIMITSMLKDINAEEKDTITF 2988

Query: 522  DPRVT---IRYIWEKDGATLGTESHPRIRLDR-NGSLHISQTWSGDIGTYT 568
            +  V    I Y W K+G  + +    ++R  +   SL+I     GD   YT
Sbjct: 2989 EVTVNYEGISYKWLKNGVEIKSTDKCQMRTKKLTHSLNIRNVHFGDAADYT 3039



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 86/350 (24%), Positives = 134/350 (38%), Gaps = 39/350 (11%)

Query: 232   EVTLEC-VANARPLIKLHIIWKKDGVLLSGG------ISDHNRRLTIPNPTGSDAGYYEC 284
             EV L+C ++ A   +K    W KDG  +              R L +     SD G Y C
Sbjct: 12034 EVILQCEISKADAPVK----WFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTC 12089

Query: 285   EAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVV---DIPCQAKGVPPPSIT 341
             +     +S    +    + ++ P   V+  E   TA  E  +   DI    K        
Sbjct: 12090 DCGTDKTSGKLDIEDREIKLVRPLHSVEVMETE-TARFETEISEDDIHANWK-------- 12140

Query: 342   WYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIA 401
               K  A+++        +     L +     D TG     A N    V++S +L V    
Sbjct: 12141 -LKGEALLQTPDCEIKEEGKIHSLVLHNCRLDQTGGVDFQAAN----VKSSAHLRVKPRV 12195

Query: 402   PNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461
               + R   D TV  G +    CE S    P   + KG+++  S  V +PR +  +  +L 
Sbjct: 12196 IGLLRPLKDVTVTAGETATFDCELSYEDIPVEWYLKGKKLEPSDKV-VPR-SEGKVHTLT 12253

Query: 462   ISPTHISDAGTYTCLATNSRGVDEASADLVV-WARTRITKPPQDQSVIKGTQASMVCGVT 520
             +    + DAG     A + +      A+L V       TKP +DQ+V +G  A + C V+
Sbjct: 12254 LRDVKLEDAGEVQLTAKDFK----THANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVS 12309

Query: 521   HDPRVTIRYIWEKDGA-TLGTESHPRIRLDRNGSLHISQTWSGDIGTYTC 569
                R   +  W K+G   L ++ +  +   R   L I      DI TYTC
Sbjct: 12310 ---RENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTC 12356



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 4/71 (5%)

Query: 1850  GKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909
             G   +T Y++E R +D   W      +  EV   +F +  L PG  Y FRV AVN+YG G
Sbjct: 18726 GGSQVTHYIVEKREADRKTWST----VTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPG 18781

Query: 1910  TPSSPSQSVPA 1920
              P+   + V A
Sbjct: 18782 VPTDVPKPVLA 18792



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 43/134 (32%), Positives = 61/134 (45%), Gaps = 10/134 (7%)

Query: 1364  GLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW- 1422
             G++ +    + + A+ R G  +    L V     D P PP    V+  DV   SV L+W 
Sbjct: 31090 GVERKDAGFYVVCAKNRFGIDQKTVELDVA----DVPDPPRG--VKVSDVSRDSVNLTWT 31143

Query: 1423  EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDI 1482
             EP SDG S +  Y ++     + RW     +     + + V  L   TSY+FRV A N  
Sbjct: 31144 EPASDGGSKITNYIVEKCATTAERWLRVGQA---RETRYTVINLFGKTSYQFRVIAENKF 31200

Query: 1483  GDSEFSEESESLTT 1496
             G S+ SE SE   T
Sbjct: 31201 GLSKPSEPSEPTIT 31214



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 66/318 (20%), Positives = 120/318 (37%), Gaps = 55/318 (17%)

Query: 30  TEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSL----------EYRYMIT 79
           T+P+++ V LEG+         G    E  W  + + ++  +L            +  I 
Sbjct: 9   TQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIP 68

Query: 80  SLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAP-RIA 138
           ++ + ++G Y     N  G        +  A        ++ QS++  + + +R   R+ 
Sbjct: 69  AVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVT 128

Query: 139 SFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDKNGDNKT 195
             P P V ++RDG +I  S    I+ E    +L+I      D+G Y V A N       T
Sbjct: 129 GIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATST 188

Query: 196 SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVT----------LECVANARPLI 245
           ++ +    E V             P K T  +  T++++          +E   +AR + 
Sbjct: 189 AELLVQGEEEV-------------PAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIA 235

Query: 246 KLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVL 305
            + ++   DG   +G    H     IP    S           RS + PS+   A L+  
Sbjct: 236 TVEMV--IDGA--AGQQLPHKTPPRIPPKPKS-----------RSPTPPSIAAKAQLARQ 280

Query: 306 EPPQFVK---EPERHITA 320
           + P  ++    P RH+ A
Sbjct: 281 QSPSPIRHSPSPVRHVRA 298



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 64/304 (21%), Positives = 114/304 (37%), Gaps = 32/304 (10%)

Query: 304   VLEPPQFVKEPERHITAEMEKVVDIPC--------QAKGVPPPSITWYKDAAVVEVEKLT 355
             VL    F  +    IT  M     +PC          +  P   + WY +   VE+++ +
Sbjct: 32362 VLSQQPFTLDHAPRITLRMRSH-RVPCGQNTRFILNVQSKPTAEVKWYHNG--VELQESS 32418

Query: 356   RFRQRNDGG---LQISGLVPDDTGMFQCFARNAAGEVQTSTYLAV-----TSIAPNITRG 407
             +    N  G   L+I     DD+G ++    N  GE      L V     T+ A      
Sbjct: 32419 KIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDE 32478

Query: 408   PLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHI 467
              +  +V   ++   A   S       +++K   + AS SV+  +    E+   L S  H 
Sbjct: 32479 EVPRSVFPELTRTEAYAVS-------SFKKTSEMEASSSVREVKSQMTETRESLSSYEHS 32531

Query: 468   SDAGTYTCLATNSRGVDEASA--DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV 525
             + A   +  A   + ++E S    +      RI   P+  +V +G  A   C    +P  
Sbjct: 32532 ASAEMKSA-ALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVP 32590

Query: 526   TIRYIWEKDGATLGTESHPRIRLDR-NGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHL 584
             T+   W + G  L T +  ++   +   +  IS   + D G Y+  V ++ G       L
Sbjct: 32591 TV--TWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTL 32648

Query: 585   RVRQ 588
              +++
Sbjct: 32649 TIQK 32652



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 102/543 (18%), Positives = 186/543 (34%), Gaps = 78/543 (14%)

Query: 137   IASFPQPQVTWFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDKNGDN 193
             + S P  +V W+ +G ++  SS+I  T  +   TL IL     D+G Y     N K    
Sbjct: 32397 VQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKG--- 32453

Query: 194   KTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKK 253
             + S   TL V   GG     A          SV    +      V++ +         K 
Sbjct: 32454 EASDYATLDV--TGGDYTTYASQRRDEEVPRSVFPELTRTEAYAVSSFK---------KT 32502

Query: 254   DGVLLSGGISDHNRRLTIPNPTGSD----AGYYECEAVLRSSSVPSVVRGAYLSVLEPPQ 309
               +  S  + +   ++T    + S     A      A L   S+        +      +
Sbjct: 32503 SEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAAR 32562

Query: 310   FVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVE---KLTRFRQRNDGGLQ 366
              + +P R +T    +     C   G P P++TW +   V+      ++T  + ++    +
Sbjct: 32563 ILTKP-RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKST--FE 32619

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETS 426
             IS +   D G +     N+ G+ +    L +      +T              V +    
Sbjct: 32620 ISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKA--RVTE-----------KAVTSPPRV 32666

Query: 427   GAPRPAITWQKGERILASGSVQLPRF--TPLESGSLLISPTHISDAGTYTCLATNSRGVD 484
              +P P        R+ +  +V+ P+   +P  S    +SPT      T            
Sbjct: 32667 KSPEP--------RVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPT------------ 32706

Query: 485   EASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHP 544
             E    L V A  +IT+  + ++      A + C V           W KDG  L    H 
Sbjct: 32707 EKVQHLPVSAPPKITQFLKAEA--SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHF 32764

Query: 545   RIRLDRNGS--LHISQTWSGDIGTYTCRVISAGGNDS----------RSAHLRVRQLPHA 592
             +     +G+  L I+     D G Y C +   GG             +S H +V ++   
Sbjct: 32765 QFHYSADGTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISET 32824

Query: 593   PEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILE--MSENNAPWTVLLASVDPKATSV 650
              +    T  +   R       +P      ++  + +  +S ++     + A+ +P+ T++
Sbjct: 32825 KKSDQKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAI 32884

Query: 651   TVK 653
               K
Sbjct: 32885 WTK 32887



 Score = 40.8 bits (94), Expect = 0.015
 Identities = 37/145 (25%), Positives = 60/145 (41%), Gaps = 11/145 (7%)

Query: 77    MITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGE-----KHQSVSHGEAAV 131
             +IT+L +     +R +  N  G    R   V +       E +        SV  G+   
Sbjct: 23189 VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLK 23248

Query: 132   IRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVND 188
             I  P I+  P+P +TW +DG  +  ++RI +T      TL I  T   D G+Y +   N 
Sbjct: 23249 IEVP-ISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANV 23307

Query: 189   KNGDNKTSQPITLTVENVGGPADPI 213
                  KT+    +T++    P  P+
Sbjct: 23308 VG--QKTASIEIVTLDKPDPPKGPV 23330



 Score = 40.4 bits (93), Expect = 0.019
 Identities = 30/105 (28%), Positives = 46/105 (43%), Gaps = 6/105 (5%)

Query: 123   SVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENT---LVILSTVAPDAG 179
             ++  G+  V+ A  I   P P+ +W + G+ I PS    IT   T   L I      DAG
Sbjct: 20389 TIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAG 20448

Query: 180   RYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNT 224
              Y + A N         + + +TV +V GP  P+  + +   K T
Sbjct: 20449 EYTITATNP---FGTKVEHVKVTVLDVPGPPGPVEISNVSAEKAT 20490



 Score = 40.0 bits (92), Expect = 0.025
 Identities = 51/175 (29%), Positives = 73/175 (41%), Gaps = 20/175 (11%)

Query: 416   GMSVVLACETSGAPRPAIT-WQKGERILASGSVQLPRFTPLESGS---LLISPTHISDAG 471
             G S +  C  S  P  AIT W K      S   + P+   +  G    L I    +SDAG
Sbjct: 11133 GSSAIFECLVS--PSTAITTWMKD----GSNIRESPKHRFIADGKDRKLHIIDVQLSDAG 11186

Query: 472   TYTCLATNSRGVDEASADLVV-WARTRITKPPQDQ-SVIKGTQASMVCGVTHDPRVTIRY 529
              YTC+         ++A LVV     R  K  +++ +V+KG    + C +  +  V    
Sbjct: 11187 EYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELNKERDV---- 11242

Query: 530   IWEKDGATLGTESHPRIRLDRNG---SLHISQTWSGDIGTYTCRVISAGGNDSRS 581
             +W KDG  +  E   RI     G   +L I+     D GTYT  V +A   +  S
Sbjct: 11243 VWRKDGKIV-VEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSS 11296



 Score = 39.3 bits (90), Expect = 0.043
 Identities = 54/219 (24%), Positives = 84/219 (38%), Gaps = 29/219 (13%)

Query: 26   PYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELT---------KFSLEYRY 76
            P F  +PV  +  LEG          G    E  W H+ +++          K       
Sbjct: 1457 PVFVLKPVSFKC-LEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSL 1515

Query: 77   MITSLDRTHAGFYRCIVRNRMGA------LLQRQTEVQVAYMGSFEEGEKHQSVSHGEAA 130
            +I     + +G +  + +NR G       L     E QV  M  F E  K+ ++  G   
Sbjct: 1516 IIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPM--FVEKLKNVNIKEGSRL 1573

Query: 131  VIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENT-----LVILSTVAPDAGRYYVQA 185
             ++  R    P P + W ++   I P     I +E T     L I STV+ D+  Y   A
Sbjct: 1574 EMKV-RATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATA 1632

Query: 186  VNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNT 224
            +N K G + T   + + VE     A+P     +I P+ T
Sbjct: 1633 IN-KAGRDTTRCKVNVEVEF----AEPEPERKLIIPRGT 1666



 Score = 38.9 bits (89), Expect = 0.056
 Identities = 39/150 (26%), Positives = 59/150 (39%), Gaps = 16/150 (10%)

Query: 76    YMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAY-----MGSFEEGEKHQSVSH---G 127
             + +TSL+      +R   +N  G    R+T   V       + + +     Q   H   G
Sbjct: 29694 HTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAG 29753

Query: 128   EAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAI---TLENTLVILSTVAPDAGRYYVQ 184
                 +  P IA  P P  +WF  G K+  S R+ +   T    L I  T   D G Y ++
Sbjct: 29754 RPVELVIP-IAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLE 29812

Query: 185   AVNDKNGDNKTSQPI-TLTVENVGGPADPI 213
                 KN    TS+ I  + ++  G P  PI
Sbjct: 29813 L---KNVTGTTSETIKVIILDKPGPPTGPI 29839



 Score = 38.9 bits (89), Expect = 0.056
 Identities = 58/210 (27%), Positives = 85/210 (40%), Gaps = 29/210 (13%)

Query: 137   IASFPQPQVTWFRDGRKIPPSSR-IAITLEN-----TLVILSTVAPDAGRYYVQAVNDKN 190
             I   P+P VTW++ G+KI P       T E+      L I S    D   Y V A N K 
Sbjct: 31713 ITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARN-KY 31771

Query: 191   GDNKTSQPITLTVENVGGPAD-PIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHI 249
             G++     +T+T+     P D  + P       N     G S V  E   +  P   L  
Sbjct: 31772 GEDSCKAKLTVTLH--PPPTDSTLRPMFKRLLANAECQEGQS-VCFEIRVSGIPPPTLK- 31827

Query: 250   IWKKDGVLLSGGISDH-------NRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 302
              W+KDG  LS G +            L I +    D GYY    V  +++  S    A+L
Sbjct: 31828 -WEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYR---VTATNTAGSTSCQAHL 31883

Query: 303   SV----LEPPQF--VKEPERHITAEMEKVV 326
              V     +  +F   +E ERH+  +++K +
Sbjct: 31884 QVERLRYKKQEFKSKEEHERHVQKQIDKTL 31913



 Score = 38.5 bits (88), Expect = 0.073
 Identities = 48/178 (26%), Positives = 71/178 (39%), Gaps = 11/178 (6%)

Query: 401  APNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQLPRFTPLESG- 458
            AP I       TV  G          G P P   W K G +I  S  +    + P ++  
Sbjct: 2077 APKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYW--YWPEDNVC 2134

Query: 459  SLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVI---KGTQASM 515
             L+I      D+ +    A N  G   + A L+V A+  IT   + Q V+   K T A+ 
Sbjct: 2135 ELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATF 2194

Query: 516  VCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQTWSGDIGTYTCRVI 572
             C  T +P V ++  W KDG  +      R+  DR    L I    + D   Y+C ++
Sbjct: 2195 ECE-TSEPFVKVK--WYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLV 2249



 Score = 37.4 bits (85), Expect = 0.16
 Identities = 40/183 (21%), Positives = 75/183 (40%), Gaps = 14/183 (7%)

Query: 40    EGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGA 99
             +G + +L    E     +  W  +N+E  K   + ++ I  L       +R    N  G 
Sbjct: 30457 DGGKEILGYWVEYRQSGDSAWKKSNKERIK---DKQFTIGGLLEATEYEFRVFAENETGL 30513

Query: 100   LLQRQTEVQVAYMGSFEEGE------KHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRK 153
                R+T + +    +  E        K  +   GEAA +   +I   P P + W+R G++
Sbjct: 30514 SRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSC-QIVGRPLPDIKWYRFGKE 30572

Query: 154   IPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPA 210
             +  S +  ++ +   +TL +++    D G Y   A N+  G+ +TS  + L       P 
Sbjct: 30573 LIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEV-GEVETSSKLLLQATPQFHPG 30631

Query: 211   DPI 213
              P+
Sbjct: 30632 YPL 30634



 Score = 37.0 bits (84), Expect = 0.21
 Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 7/87 (8%)

Query: 313  EPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDG--GLQISGL 370
            EP R +  E  +     C+  G P P + WY +  ++   K  RFR R DG   L I   
Sbjct: 1848 EPVRVLEGETAR---FRCRVTGYPQPKVNWYLNGQLIRKSK--RFRVRYDGIHYLDIVDC 1902

Query: 371  VPDDTGMFQCFARNAAGEVQTSTYLAV 397
               DTG  +  A N  G ++    L +
Sbjct: 1903 KSYDTGEVKVTAENPEGVIEHKVKLEI 1929



 Score = 37.0 bits (84), Expect = 0.21
 Identities = 56/211 (26%), Positives = 78/211 (36%), Gaps = 31/211 (14%)

Query: 139  SFPQPQVTWFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVNDKNGDNKT 195
            S P  +  WFR+GR + P  R    +E   + L I    A D G+Y       K  D +T
Sbjct: 8769 SVPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQY-----TCKYEDLET 8823

Query: 196  SQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDG 255
            S  + +        A+PI  T  I      VV+     T EC  +    I   + W K  
Sbjct: 8824 SAELRI-------EAEPIQFTKRI---QNIVVSEHQSATFECEVSFDDAI---VTWYKGP 8870

Query: 256  VLLSGGISDHNRR------LTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQ 309
              L+     + R       +TI N T  D G Y   A L            YL+  E   
Sbjct: 8871 TELTESQKYNFRNDGRCHYMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKL 8930

Query: 310  FVKEPERHITAEMEKVVDIPCQAKGVPPPSI 340
             +K P+  I      +  +P +A  VPP  I
Sbjct: 8931 ELKPPD--IPDSRVPIPTMPIRA--VPPEEI 8957



 Score = 36.6 bits (83), Expect = 0.28
 Identities = 34/162 (20%), Positives = 68/162 (41%), Gaps = 17/162 (10%)

Query: 56    LEFKWLHNN--------RELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEV 107
             +E +WL NN         ++      +R  I  +     G YR I +++     + + ++
Sbjct: 12940 VEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK-----EARAKL 12994

Query: 108   QVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENT 167
             ++A     +  ++   V  G+   +  P  A +P+ +  WF++   +   +      + +
Sbjct: 12995 ELAAAPKIKTADQDLVVDVGKPLTMVVPYDA-YPKAEAEWFKENEPLSTKTIDTTAEQTS 13053

Query: 168   LVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGP 209
               IL     D GRY +  + +K+G  K    I L V +V GP
Sbjct: 13054 FRILEAKKGDKGRYKI-VLQNKHG--KAEGFINLKVIDVPGP 13092



 Score = 36.2 bits (82), Expect = 0.36
 Identities = 35/147 (23%), Positives = 56/147 (38%), Gaps = 10/147 (6%)

Query: 73    EYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGE--------KHQSV 124
             E +Y +T L       +R +  N  G          V      E  E        + Q +
Sbjct: 17171 ETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHI 17230

Query: 125   SHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQ 184
               G+   + A  I   P P+VTW ++ R  P  +RI +T   + + +   A + G  Y  
Sbjct: 17231 KVGDTLRLSAI-IKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSL 17289

Query: 185   AVNDKNGDNKTSQPITLTVENVGGPAD 211
              V +  G +KT     L ++  G P D
Sbjct: 17290 TVENPAG-SKTVSVKVLVLDKPGPPRD 17315



 Score = 35.4 bits (80), Expect = 0.61
 Identities = 30/139 (21%), Positives = 56/139 (40%), Gaps = 14/139 (10%)

Query: 59    KWLHNNRELTKFSLEYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEG 118
             KW+     + +  +E    +T L+      YR    NR GA    +   ++  + + E  
Sbjct: 13633 KWVACGEPVAETKME----VTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAP 13688

Query: 119   EKHQSVSHGEAAVIRA-------PRIASFPQPQVTWFRDGRKIPPSSRIAIT---LENTL 168
             E    V       ++A         +   P+P++TW +    +    RI I     ++T+
Sbjct: 13689 EIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTV 13748

Query: 169   VILSTVAPDAGRYYVQAVN 187
              I+ +   D G Y ++AVN
Sbjct: 13749 TIVDSKRSDTGTYIIEAVN 13767



 Score = 35.0 bits (79), Expect = 0.80
 Identities = 22/66 (33%), Positives = 33/66 (50%), Gaps = 3/66 (4%)

Query: 124  VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLE--NTLVILSTVAPDAGRY 181
            V  GE A  R  R+  +PQP+V W+ +G+ I  S R  +  +  + L I+   + D G  
Sbjct: 1852 VLEGETARFRC-RVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIVDCKSYDTGEV 1910

Query: 182  YVQAVN 187
             V A N
Sbjct: 1911 KVTAEN 1916



 Score = 35.0 bits (79), Expect = 0.80
 Identities = 25/87 (28%), Positives = 37/87 (42%), Gaps = 4/87 (4%)

Query: 505   QSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLD-RNGSLHISQTWSGD 563
             +S   G+ A   C V+    +T    W KDG+ +      R   D ++  LHI      D
Sbjct: 11128 ESEFVGSSAIFECLVSPSTAITT---WMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSD 11184

Query: 564   IGTYTCRVISAGGNDSRSAHLRVRQLP 590
              G YTC +       + +A L V +LP
Sbjct: 11185 AGEYTCVLRLGNKEKTSTAKLVVEELP 11211



 Score = 34.7 bits (78), Expect = 1.0
 Identities = 41/184 (22%), Positives = 78/184 (42%), Gaps = 16/184 (8%)

Query: 53    SWPLEFKWLHNNREL-TKFS--LEYRYMITSLDRTHAGFYRCIVRNRMGALLQ-RQTEVQ 108
             S+ +E + L N R L   FS  LE  + ++ L    A  +R I +N  GA+    +    
Sbjct: 21390 SYIVEKRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDA 21449

Query: 109   VAYMGSFEEGEKHQSVSHGEAAVIRAPR-------IASFPQPQVTWFRDGRKIPPSSRIA 161
             +      E  +    V   +  +++A         ++  P P + W +DG+++  ++++ 
Sbjct: 21450 ITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLE 21509

Query: 162   ITL---ENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTII 218
             I +      LV   +   D+G Y + A N   G  K    + + ++  G P  P+A T +
Sbjct: 21510 IKIADFSTNLVNKDSTRRDSGAYTLTATN-PGGFAKHIFNVKV-LDRPGPPEGPLAVTEV 21567

Query: 219   IPPK 222
                K
Sbjct: 21568 TSEK 21571



 Score = 34.7 bits (78), Expect = 1.0
 Identities = 22/76 (28%), Positives = 35/76 (46%), Gaps = 6/76 (7%)

Query: 141   PQPQVTWFRDGRKIPPSSRIAITLENTLVILS---TVAPDAGRYYVQAVNDKNGDNKTSQ 197
             PQ  V W +DG+ +  ++R+ ++   T+  LS       D G Y +      N     + 
Sbjct: 25422 PQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCV---SNSAGSITV 25478

Query: 198   PITLTVENVGGPADPI 213
             PIT+ V +  GP  PI
Sbjct: 25479 PITIIVLDRPGPPGPI 25494



 Score = 33.5 bits (75), Expect = 2.3
 Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 6/94 (6%)

Query: 123   SVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRI-AITLENT--LVILSTVAPDAG 179
             +V  GE   +  P I   P P VTW +D   +  ++R+ A + EN   L I      D G
Sbjct: 22158 TVLAGEDLKVDVPFIGR-PTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVG 22216

Query: 180   RYYVQAVNDKNGDNKTSQPITLTVENVGGPADPI 213
              Y V+  N      +T   I L  +  G P  P+
Sbjct: 22217 HYVVKLTNSAGEAIETLNVIVL--DKPGPPTGPV 22248



 Score = 33.1 bits (74), Expect = 3.0
 Identities = 34/155 (21%), Positives = 67/155 (43%), Gaps = 18/155 (11%)

Query: 73    EYRYMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQV-----AYMG-------SFEEGEK 120
             E +++I+ L +     +R   RN +G++      V       +Y G        + E  K
Sbjct: 26824 ETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVK 26883

Query: 121   HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGR 180
             +++   G +  +RA  I+  P P + W++D +++  ++ + +  ENT  + S +  DA R
Sbjct: 26884 YRA---GTSVKLRAG-ISGKPAPTIEWYKDDKELQTNALVCV--ENTTDLASILIKDADR 26937

Query: 181   YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAP 215
                     K  +   S   T+ V+ +  P  P  P
Sbjct: 26938 LNSGCYELKLRNAMGSASATIRVQILDKPGPPGGP 26972



 Score = 31.6 bits (70), Expect = 8.9
 Identities = 24/86 (27%), Positives = 34/86 (39%), Gaps = 1/86 (1%)

Query: 427  GAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEA 486
            G P   + W    + L + + +L         SL     +  D+G  TC ATN  G D  
Sbjct: 1730 GDPTMVVEWLHDGKPLEAAN-RLRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHT 1788

Query: 487  SADLVVWARTRITKPPQDQSVIKGTQ 512
            SA L+V     + +  Q     KG Q
Sbjct: 1789 SATLIVKDEKSLVEESQLPEGRKGLQ 1814


>gi|110349717 titin isoform novex-2 [Homo sapiens]
          Length = 27118

 Score =  246 bits (629), Expect = 1e-64
 Identities = 395/1726 (22%), Positives = 665/1726 (38%), Gaps = 198/1726 (11%)

Query: 147  WFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203
            W ++G ++P  +R++  ++   + L I     PD G Y V A  DK      S    L +
Sbjct: 6461 WTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDK------SVAELLII 6514

Query: 204  ENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGIS 263
            E         APT  +       V    +    C  +     K ++ W ++G  +  G  
Sbjct: 6515 E---------APTEFVEHLEDQTVTEFDDAVFSCQLSRE---KANVKWYRNGREIKEGKK 6562

Query: 264  ------DHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKE-PER 316
                      RL I +    D   Y C    R S     V    + ++ PPQ + E P  
Sbjct: 6563 YKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGA 6622

Query: 317  HIT--AEMEKVVDIPCQAKGVPPPSITWYKD-AAVVEVEKLTRFRQRNDGGLQISGLVPD 373
             +   AE+ K               + W ++   VV+ +K     +     LQI  + P 
Sbjct: 6623 DVVFLAELNK-----------DKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPR 6671

Query: 374  DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
            D G ++  A++   E +    LA    AP I     D  V  G  + +       P+   
Sbjct: 6672 DQGEYRFIAKDK--EARAKLELAA---APKIKTADQDLVVDVGKPLTMVVPYDAYPKAEA 6726

Query: 434  TWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVW 493
             W K    L++ ++     T  E  S  I      D G Y  +  N  G  E   +L V 
Sbjct: 6727 EWFKENEPLSTKTID----TTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKV- 6781

Query: 494  ARTRITKPPQDQSVIKGTQASMVCG----VTHDPRVTIRYIWEKDGATLGTESHPRIRLD 549
                +  P ++  V +     +       +T      I Y+ E+      T     +  D
Sbjct: 6782 --IDVPGPVRNLEVTETFDGEVSLAWEEPLTDGGSKIIGYVVERRDIKRKTWV---LATD 6836

Query: 550  RNGSLHISQTWSGDIGT-YTCRV-----ISAGGNDSRSAHLRVRQLPHAPEHPV-ATLST 602
            R  S   + T     G  Y  RV     +  G        +  R     P  P+  T++ 
Sbjct: 6837 RAESCEFTVTGLQKGGVEYLFRVSARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITD 6896

Query: 603  VERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSY 661
            V R  ++LTW  P +DG + +  Y++E+ +  +       +V  +  S TV  +V  + Y
Sbjct: 6897 VNRFGVSLTWEPPEYDGGAEITNYVIELRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEY 6956

Query: 662  QFRLCAVNDVGKGQFSKDTE--RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQ 719
             FR+ A N +G G+ S  T   +V+ P E P+ PP N+ +S +T  S+ ++W+PP +   
Sbjct: 6957 SFRVRAQNRIGVGKPSAATPFVKVADPIERPS-PPVNLTSSDQTQSSVQLKWEPPLKDGG 7015

Query: 720  NGILKGYIIRYCLAGLP--VGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGV 777
            + IL GYII  C  G    +    K + +       LE       Y   V+A N AG+  
Sbjct: 7016 SPIL-GYIIERCEEGKDNWIRCNMKLVPELTYKVTGLEK---GNKYLYRVSAENKAGVSD 7071

Query: 778  YSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQE 837
             S  +   T       P  ++ A       I      P+P  I   + GY          
Sbjct: 7072 PSEILGPLTADDAFVEPTMDLSAFKDGLEVI-----VPNPITILVPSTGYP--------- 7117

Query: 838  EEVTMVTARPNFQDSI-HVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPG 896
                  TA   F D +   G    +K  + Y   V+  +   D    T +L    + + G
Sbjct: 7118 ----RPTATWCFGDKVLETGDRVKMKTLSAYAELVISPSERSDKGIYTLKLENRVKTISG 7173

Query: 897  PVG-----------HLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNR-TNTRVT 943
             +             L F +I   S+ ++W+ P +  G  LTGY +   E +R T T+V 
Sbjct: 7174 EIDVNVIARPSAPKELKFGDITKDSVHLTWEPPDDDGGSPLTGYVVEKREVSRKTWTKVM 7233

Query: 944  HYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA--STISSGVPPELPGPPTNLGI 1001
             ++ +  LE+ V  L     Y  +V A    G G+ +     ++   P  +P PP N+  
Sbjct: 7234 DFVTD--LEFTVPDLVQGKEYLFKVCARNKCGPGEPAYVDEPVNMSTPATVPDPPENVKW 7291

Query: 1002 SNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARS-MEVP 1059
             +    S+ L + P   DG + I  ++VE         ++W+       EP A + MEV 
Sbjct: 7292 RDRTANSIFLTWDPPKNDGGSRIKGYIVER---CPRGSDKWVAC----GEPVAETKMEVT 7344

Query: 1060 DLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTL--QAPPDM-----APANVSLRTASETS 1112
             L     Y++R++ +N  G S PS+P+ +IQ +  Q  P++       A ++++  ++  
Sbjct: 7345 GLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIE 7404

Query: 1113 LWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVER--DYTIEDLEEWTE 1170
            L             G PE    KI ++++D   K    +  + V +    TI D +    
Sbjct: 7405 L--------PATVTGKPEP---KITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDT 7453

Query: 1171 YRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNG 1230
                ++A N  G      T V           P        T+ S L+ W+  P  D   
Sbjct: 7454 GTYIIEAVNVCGRA----TAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNP-PRDDGGS 7508

Query: 1231 LVLGYKVMYKEKDSDTQPRF-WLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP-S 1288
             +  Y V  +  DS+   +    V+  + ++ +L    +Y+    +V A    G G P  
Sbjct: 7509 KITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKEYIF---RVAAENMYGVGEPVQ 7565

Query: 1289 HPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTA 1348
              PI  +   D PGPP  +   ++   +V L W  P    G  +      RL+  T    
Sbjct: 7566 ASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKWV 7625

Query: 1349 TVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL--VVTTEKRDRPQPPSRP 1406
                +      Y   GL  +  Y FR+ A+   G G+ +++   ++  +  D P PP +P
Sbjct: 7626 RCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKP 7685

Query: 1407 MVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDR 1465
             V  +DV   SV L+W +P  DG + +  Y I+  +  +  W   +  V    +  ++  
Sbjct: 7686 TV--KDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTDEWVRVAEGVP--TTQHLLPG 7741

Query: 1466 LKPFTSYKFRVKATNDIGDSEFSEESES-LTTLQAAPDEAPTILSVTPHTTTSVLIRWQP 1524
            L     Y FRV+A N  G+SE SE S+  L   +  P   P  L V   T  +  ++W  
Sbjct: 7742 LMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTV 7801

Query: 1525 PAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQY 1584
            P +D     +  + +  R++  +G               W  + +       +   LT+ 
Sbjct: 7802 PEKDG-GSPITNYIVEKRDVRRKG---------------WQTVDTTVKDTKCTVTPLTEG 7845

Query: 1585 ELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPT--AAPRNVVVHGATATQLDV 1642
             L        Y  R++  NA+G+   +  ++  + +   T    P  + V   T   +D+
Sbjct: 7846 SL--------YVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDL 7897

Query: 1643 TWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAA 1702
             WEPP  D     IQ Y I   E       +  KT    + + ++ ++   T     V A
Sbjct: 7898 KWEPPKNDG-GRPIQRYVIEKKERLGTRWVKAGKTAG-PDCNFRVTDVIEGTEVQFQVRA 7955

Query: 1703 FNAAGDGPRSTPTQ---GQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYR 1758
             N AG G  S PT+    +   + PS P  +  ++     + ++W+ P+   G  + GY 
Sbjct: 7956 ENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYH 8015

Query: 1759 LVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKD-LAEGVTYRFRIRA 1803
            +  E C PV G  K + V+ +    L  KV++ +     Y  R+RA
Sbjct: 8016 V--EMC-PV-GTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRA 8057



 Score =  225 bits (573), Expect = 4e-58
 Identities = 433/1960 (22%), Positives = 731/1960 (37%), Gaps = 276/1960 (14%)

Query: 72    LEYRYMITSLDRTHAGFYRCIVRNRMGAL---------LQRQTEVQVAYMGSFEEGEKHQ 122
             +E ++ ++ L       +R I +N  GA+         +  + EV++  +    +     
Sbjct: 17271 IETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTI 17330

Query: 123   SVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAIT---LENTLVILSTVAPDAG 179
              V+ GE   + A  +   P P + W R  ++I  S+R  I     +  L++   +  D G
Sbjct: 17331 VVNAGETFRLEAD-VHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGG 17389

Query: 180   RYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVA 239
             +Y ++A    N     S P+ + V +  GP          P     V   TSE       
Sbjct: 17390 QYILRA---SNVAGSKSFPVNVKVLDRPGP----------PEGPVQVTGVTSE------- 17429

Query: 240   NARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAG-YYECEAVLRSSSVPSVVR 298
                   K  + W      L  G SD +  +     T   A      E V  S  V  ++ 
Sbjct: 17430 ------KCSLTWSPP---LQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLE 17480

Query: 299   G---AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV------ 349
             G    +  +      V EP       M+    +P   K +   +I   KD+  V      
Sbjct: 17481 GNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIA--KDSMTVCWNRPD 17538

Query: 350   ----------EVEKLTRF---------RQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQ 390
                        VEK  R          R+  D  L+++GL  D    F+  A NAAG  +
Sbjct: 17539 SDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGE 17598

Query: 391   TS-TYLAVTSIAPNITRGP------LDST-----------VIDGMSVVLA-----CETSG 427
              S   +   +  P    GP      +D+T           + DG S +L      C+   
Sbjct: 17599 PSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEICKADE 17658

Query: 428   APRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEA- 486
                  +T Q G R+           T  E   L    T   +     C A N  G+ EA 
Sbjct: 17659 EEWQIVTPQTGLRV-----------TRFEISKL----TEHQEYKIRVC-ALNKVGLGEAT 17702

Query: 487   SADLVVWARTRITKPPQD------QSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGT 540
             S    V    ++  P  D      + ++     S    +    R T    W ++      
Sbjct: 17703 SVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEG---- 17758

Query: 541   ESHPRIRLDRNGS---LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPV 597
             E   ++++++  +   L I      D G Y  ++ ++ G+ S    ++V   P  P++  
Sbjct: 17759 EFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDTPGPPQN-- 17816

Query: 598   ATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLV 656
               +  V + +  L W  P  DG + +  Y+++  E+       ++S   K TS  V+ L 
Sbjct: 17817 LAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSK-TSFKVENLT 17875

Query: 657   PARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPE 716
                 Y FR+ A N+ G G   +  + V   E  P +PP  V  +  +  S  + W+ P  
Sbjct: 17876 EGAIYYFRVMAENEFGVGVPVETVDAVKAAE--PPSPPGKVTLTDVSQTSASLMWEKPEH 17933

Query: 717   SHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLG 776
                + +L GY++     G     ++  + ++ V N ++  L     Y+  V AYN  G  
Sbjct: 17934 DGGSRVL-GYVVEMQPKGTE---KWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKG-- 17987

Query: 777   VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQF-------INGINQGYKL 829
                   ++  + GVP +       + T   +++  +N  S Q        I  I +    
Sbjct: 17988 -----KSDPRVLGVPVIA-----KDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPN 18037

Query: 830   IAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVR 889
             I+W   ++ E    T R N +++     V  +K+  +        T       +T  L  
Sbjct: 18038 ISW--VKDGEPLKQTTRVNVEETA-TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSV 18094

Query: 890   THEDVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHYLP 947
                + PG PVG + F E+    + +SW+ P    G  ++ Y +      R  T  T ++ 
Sbjct: 18095 IVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVE----KRDTTTTTWHMV 18150

Query: 948   NVTL---EYRVTGLTALTTYTIEVAAMTSKGQ-GQVSASTISSGVPPELPGPPTNLGISN 1003
             + T+     ++T L   T Y   + A    G+   + +  +    P + PGPP    +++
Sbjct: 18151 SATVARTTIKITKLKTGTEYQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTS 18210

Query: 1004  IGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN 1062
             I    + +Q+  P  DG T I  + +E +     E    L +            +   L+
Sbjct: 18211 ISKDQMLVQWHEPVNDGGTKIIGYHLEQK-----EKNSILWVKLNKTPIQDTKFKTTGLD 18265

Query: 1063  PFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPE 1122
                 Y F++   NIVG   PS+ S     +   P   P        +  ++ L+W    +
Sbjct: 18266 EGLEYEFKVSAENIVGIGKPSKVSECF--VARDPCDPPGRPEAIVITRNNVTLKW---KK 18320

Query: 1123  MEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182
               Y+G  +  GY ++  +    G+ +     + +E ++T+  L E   Y  +V A NA G
Sbjct: 18321 PAYDGGSKITGYIVE-KKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAG 18379

Query: 1183  --SGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSE--VPEADRNGLVLGYKVM 1238
               S P   +     R+ + +    N S        ++V   E  V EAD  G  +   V 
Sbjct: 18380 NFSEPSDSSGAITARDEIDA---PNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVW 18436

Query: 1239  YKE-KDSDTQPRFWLVEGNSSRSAQL------TGLGKYVLYEVQVLAFTRIGDGSPSHPP 1291
              K+ K+ +       ++    ++  +      T  G+Y+L    V        G     P
Sbjct: 18437 SKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKLSNV--------GGTKSIP 18488

Query: 1292  ILERTLDDVPGPPMGIL-FPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATV 1350
             I  + LD  PGPP G L    V      L W PP    G  +++ I  +  T+  +   V
Sbjct: 18489 ITVKVLDR-PGPPEGPLKVTGVTAEKCYLAWNPPLQDGGANISHYIIEKRETSRLSWTQV 18547

Query: 1351  EVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTT-EKRDRPQPPSRPMVQ 1409
                   A  Y  T L P + Y+FR+ A  + G GE  E+  VT       P PPS P V 
Sbjct: 18548 ST-EVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVS 18606

Query: 1410  QEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKP 1468
                +   S++++W  P  DG + +  Y ++ R+    RW   +     +     V  L  
Sbjct: 18607 A--ITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDL-RLRVTGLTE 18663

Query: 1469  FTSYKFRVKATNDIGDSEFSEESESLTTLQAA-PDEAPTILSVTPHTTTSVLIRWQPPAE 1527
               SY+FRV A N  G  E SE S       A  P   P+   VT  + +SV + W  P  
Sbjct: 18664 GHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKP-- 18721

Query: 1528  DKINGILLGFRIRYRELLYEG---LRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQY 1584
                              +Y+G   ++G+ +         W   T    ++        Q+
Sbjct: 18722 -----------------IYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQG------KQF 18758

Query: 1585  ELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAVP------TAAPRNVVVHGATA 1637
              +  L ++  Y  R+   N+ G G P++ P  V   E +        A  R VVV  A+A
Sbjct: 18759 TVTKLKENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASA 18818

Query: 1638  T-QLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE-NSVKLKNLTGYTA 1695
             T +L VT +  P               WE   G LT+R +    +    + + N+T + +
Sbjct: 18819 TLRLFVTIKGRPEPEVK----------WEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDS 18868

Query: 1696  YMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILE 1755
                ++   N +G     T         +PSAP ++   E+   SV +SWE P    G   
Sbjct: 18869 GRYNLTLENNSGS---KTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGA-- 18923

Query: 1756  GYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEAN 1815
               ++        +   K         +    ++++L EG +Y FR+ A    YG  + A 
Sbjct: 18924 --KITNYIVEKRETTRKAYATITNNCTKTTFRIENLQEGCSYYFRVLASN-EYGIGLPAE 18980

Query: 1816  VTTGPGEGA--PGPPG-VPIIVRYSSAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDI 1871
              TT P + +  P PPG V ++    +   I W   +  G   IT YV+E +      W  
Sbjct: 18981 -TTEPVKVSEPPLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWST 19039

Query: 1872  LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP 1911
                    +V +   ++  L  G  Y FRV AVN+ G   P
Sbjct: 19040 C-----TQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDP 19074



 Score =  218 bits (556), Expect = 4e-56
 Identities = 418/1900 (22%), Positives = 731/1900 (38%), Gaps = 252/1900 (13%)

Query: 136   RIASFPQPQVTWFRDGRKIPPS----------SRIAITLENTLVILSTVAPDAGRYYVQA 185
             +I   P P +TWF+   K P +          +++ +    TLVI  +   D G Y + A
Sbjct: 9834  KIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITA 9893

Query: 186   VNDKNGDNKTSQPITLTVENVGGPADPIAPTII------------IPPKNTSVVAGTSEV 233
             VN+    +K      + +  +G P  P+ P                PPK+      T+ V
Sbjct: 9894  VNNLGTASKE-----MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKITNYV 9948

Query: 234   TLECVANARPLIKLHIIWKKDGVLLSGGISDHNR--RLTIPNPTG-SDAGYYECEAVLRS 290
               +  AN +  + +    K+    +   +  H    R+   N  G  +    E E     
Sbjct: 9949  IEKREANRKTWVHVSSEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPETARNL 10008

Query: 291   SSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWY--KDAAV 348
              SVP           + P         +T   E+      +  G  P +  W   KD   
Sbjct: 10009 FSVPGAP--------DKPTVSSVTRNSMTVNWEEP-----EYDGGSPVTGYWLEMKDTTS 10055

Query: 349   VEVEKLTR--FRQRNDG-GLQISGLVPDDTGMFQCFARNAAG----EVQTSTYLAVTSIA 401
                +++ R   +    G   +++GL+      F+ +A NAAG     + +    A   IA
Sbjct: 10056 KRWKRVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIA 10115

Query: 402   P---------NITRGPLD----STVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQ 448
             P         + T+   D      + DG S V              W+KG+     G+  
Sbjct: 10116 PPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL 10175

Query: 449   LPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDE-ASADLVVWARTRITKPP----- 502
             +   T L+ G+             +   A N  G+ E      V+  + R+  P      
Sbjct: 10176 V--VTGLKEGAFY----------KFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDA 10223

Query: 503   --QDQSVIK-GTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQT 559
               +D+ V+  G    ++  V+  P  T+   W  +  TL  E+        + S+ I   
Sbjct: 10224 SVRDRIVVHAGGVIRIIAYVSGKPPPTVT--WNMNERTLPQEATIETTAI-SSSMVIKNC 10280

Query: 560   WSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-G 618
                  G Y+    +  G   ++  + V  +P     P      +   +  LTW  P D G
Sbjct: 10281 QRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLA-HNLTNESCKLTWFSPEDDG 10339

Query: 619   NSPLIRYILEMSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFS 677
              SP+  Y++E  E++   WT +  +V  +  + TV+GL+  ++Y FR+ A N +G G F 
Sbjct: 10340 GSPITNYVIEKRESDRRAWTPVTYTVTRQ--NATVQGLIQGKAYFFRIAAENSIGMGPFV 10397

Query: 678   KDTERVSLPEEPPTAP--PQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGL 735
             + +E + +  EP T P  P+++     T  ++ + W PP   +  G     II Y L   
Sbjct: 10398 ETSEALVI-REPITVPERPEDLEVKEVTKNTVTLTWNPP--KYDGG---SEIINYVLESR 10451

Query: 736   PVGYQ-FKNITDADV--NNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPT 792
              +G + F  +T+ ++      ++ L     YE  V+A N  G G  S      T +    
Sbjct: 10452 LIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKD--E 10509

Query: 793   VPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQ----EEEVTMVTARPN 848
             + P  +H +  +  TIR           +G  +    ++W  ++    E++ T +   P 
Sbjct: 10510 LAPPTLHLDFRDKLTIRVGEAFALTGRYSG--KPKPKVSWFKDEADVLEDDRTHIKTTPA 10567

Query: 849   FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILD 908
                ++ +  +   +  +  +  V+  +T   G R     V   +    PVG +SF E+  
Sbjct: 10568 ---TLALEKIKAKRSDSGKYCVVVENST---GSRKGFCQVNVVDRPGPPVGPVSFDEVTK 10621

Query: 909   TSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTR-VTHYLPNVTLEYRVTGLTALTTYTI 966
               + +SW+ P +  G  +T Y I  +E  +     VT      T   +V+ L     Y  
Sbjct: 10622 DYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTC--KVSKLLEGKDYIF 10679

Query: 967   EVAAMTSKGQGQVSASTISSGVPPE----LPGPPTNLGISNIGPRSVTLQFRPGYDGKTS 1022
              + A    G   +S   +S  +  +    +P  P    ++ +   S  + +   +DG   
Sbjct: 10680 RIHAENLYG---ISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVTWNKPHDGGKP 10736

Query: 1023  ISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPP 1082
             I+ +++E +  +    + W  + +    P  +   VPDL     Y FR+   N +G   P
Sbjct: 10737 ITNYILEKRETM---SKRWARVTKDPIHPYTK-FRVPDLLEGCQYEFRVSAENEIGIGDP 10792

Query: 1083  SQPSRKIQTLQ--APPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSR 1140
             S PS+ +      A P   P N      +  S+ L W P     ++G  + +GY ++Y +
Sbjct: 10793 SPPSKPVFAKDPIAKPS-PPVNPEAIDTTCNSVDLTWQP---PRHDGGSKILGYIVEYQK 10848

Query: 1141  -SDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWS---QTVVGRTRE 1196
               D   +  +H  +   E  Y +  L +   Y+ +V A NA G    +   + V+ + R 
Sbjct: 10849 VGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRL 10908

Query: 1197  SVPS-------SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSD--TQ 1247
               P        +   ++    T   S +++    P           KV +K++D D  T+
Sbjct: 10909 EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFP-----------KVTWKKEDRDAPTK 10957

Query: 1248  PRFWLVEGNSS---RSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPP 1304
              R  +    S    R+A     G Y L          + + + S    ++  + D PGPP
Sbjct: 10958 ARIDVTPVGSKLEIRNAAHEDGGIYSL---------TVENPAGSKTVSVKVLVLDKPGPP 11008

Query: 1305  MGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATG 1364
               +   E+R  S  L W+ P    G ++   +  R +  +A  + +   +   + + A  
Sbjct: 11009 RDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKK-KSHFAKH 11067

Query: 1365  LKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPM-VQQEDVRARSVLLSW- 1422
             L   + YLFR+ A+ + G G   E      +  D   PP  P  +   DV    V L W 
Sbjct: 11068 LNEGNQYLFRVAAENQYGRGPFVET-PKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWN 11126

Query: 1423  EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDI 1482
             +P  DG SP+  Y ++ +E  +  W       +      +V  L+   +Y+FRVKA N +
Sbjct: 11127 KPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLEC---VVTGLQQGKTYRFRVKAENIV 11183

Query: 1483  GDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDK----INGILL--G 1536
             G                 PD      +  P      L+   PP+ +     I G+++  G
Sbjct: 11184 G--------------LGLPD------TTIPIECQEKLV---PPSVELDVKLIEGLVVKAG 11220

Query: 1537  FRIRYRELLYEGLRGFTLRGINNPGATWA------ELTSMYSMRNLSRPSLTQYELDNLN 1590
               +R+  ++         RG+  P A W       +    Y++   +  S+    + N  
Sbjct: 11221 TTVRFPAII---------RGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLT--IKNCL 11269

Query: 1591  KHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLD 1650
             +    E +++V NA G    +    V      PT  P N++    T   + ++W+PP  D
Sbjct: 11270 RRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG-PINIL--DVTPEHMTISWQPPK-D 11325

Query: 1651  SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710
                  +  Y +   + ++   T  V +   ++  +K+ +L     Y+  V A N  G GP
Sbjct: 11326 DGGSPVINYIVEKQDTRKD--TWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGP 11383

Query: 1711  R--STPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPV 1767
                STPT  + + + PS P     +++T  +  VSW  P+   G  + GY   Y     V
Sbjct: 11384 PLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKSDGGSPITGY---YMERREV 11440

Query: 1768  DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT----YGPEIEANVTTGPGEG 1823
              G  K V V+    + L  +V  L EG TY FR+ A+         P  +      P + 
Sbjct: 11441 TG--KWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIK- 11497

Query: 1824  APGPPGVPIIVRYSSAIA-IHWSSG-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVS 1881
              PGPP  P +   S   A + W+     G  PI  YV+E +      W+ + KD  + + 
Sbjct: 11498 PPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKD--ELIR 11555

Query: 1882  SYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQ 1921
                F +  L  G  Y FR+ A N  G G P   ++SV A+
Sbjct: 11556 QCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAK 11595



 Score =  215 bits (548), Expect = 3e-55
 Identities = 424/1882 (22%), Positives = 697/1882 (37%), Gaps = 278/1882 (14%)

Query: 378   FQCFARNAAG-----EVQTSTYLAVTSIAPNITRGPLDSTVID---GMSVVLACETSGAP 429
             F+  A+N AG     E  +S  +    I P      + + +I    G    +    SG P
Sbjct: 22311 FRVKAKNDAGYSEPREAFSSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRP 22370

Query: 430   RPAITWQKGE-RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASA 488
              P +TW+  E R+  +  V +   T  +  +L +  +   D+G Y     N+ GV   S 
Sbjct: 22371 APKVTWKLEEMRLKETDRVSIT--TTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSV 22428

Query: 489   DLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT--IRYIWEK--DGATLGTESHP 544
              +VV  R      P + S +      +  G   D   T    YI EK   G T     + 
Sbjct: 22429 TVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNS 22488

Query: 545   RIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLST-- 602
              ++  +    H+++        Y+ RV S    +       +   P   EHP    S   
Sbjct: 22489 SVKRTQIKVTHLTKYME-----YSFRVSS---ENRFGVSKPLESAPIIAEHPFVPPSAPT 22540

Query: 603   ------VERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGL 655
                   V   A+++ W +P+ DG S +I Y +E  E N    V    V     +  V GL
Sbjct: 22541 RPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGL 22600

Query: 656   VPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPP 715
             V    YQFR  A+N  G  + S +  R  + + P  AP +  +    T  ++ + W  P 
Sbjct: 22601 VEGLEYQFRTYALNAAGVSKAS-EASRPIMAQNPVDAPGRPEVTDV-TRSTVSLIWSAPA 22658

Query: 716   ESHQNGILKGYII-RYCLAGLPVGYQFK-NITDADVNNLLLEDLIIWTNYEIEVAAYNSA 773
                 + ++ GYII R  ++ +  G   K N T    N   +  L     YE  V A N+A
Sbjct: 22659 YDGGSKVV-GYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAA 22717

Query: 774   GLGVYSSKVTEWTLQGVPTVPP-----GNVHAEATNSTTIRFTWNAPSPQFINGINQGYK 828
             G+    S+ T          PP       +H +     TIR   +      + G  +  K
Sbjct: 22718 GVISKGSESTGPVTCRDEYAPPKAELDARLHGDLV---TIRAGSDLVLDAAVGGKPEP-K 22773

Query: 829   LIAWEPEQE----EEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRST 884
             +I  + ++E    E+V++          I     S   K+T    +         G ++ 
Sbjct: 22774 IIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNA-------SGTKAV 22826

Query: 885   PQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVT 943
               +V+   D PGP G L+ S +      ++W  P E  G  +T Y +   E +R N  + 
Sbjct: 22827 SVMVKVL-DSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRLNWVIV 22885

Query: 944   HYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG-QVSASTI---SSGVPPELPGPPTNL 999
                   TL Y VT L     Y   V A+   G G  V +  I   +S   P  PG P  +
Sbjct: 22886 EG-ECPTLSYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPGIPEEV 22944

Query: 1000  GISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEV 1058
             G    G   + +Q+ +P  DG   IS +LV+ +     +   W  +++     D R ++V
Sbjct: 22945 GT---GKEHIIIQWTKPESDGGNEISNYLVDKREK---KSLRWTRVNKDYVVYDTR-LKV 22997

Query: 1059  PDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAP----PDMAPANVSLRTASETSLW 1114
               L     Y FR+  VN  G S PS+ S  I   +      P  AP  V     S +  W
Sbjct: 22998 TSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKHSISLAW 23057

Query: 1115  LRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQ 1174
              + M      Y+G  + VGY ++    D       H        ++T+ DL+   +Y  +
Sbjct: 23058 TKPM------YDGGTDIVGYVLEMQEKDTDQWYRVHTNATIRNTEFTVPDLKMGQKYSFR 23111

Query: 1175  VQAFNAIGSGPWSQTVVGRT---RESVPSSGPTN-----VSALATTSSSMLVRWSEVPEA 1226
             V A N  G   +S+++       R  +P     +     V+  A  S  ++V  S  P  
Sbjct: 23112 VAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPP 23171

Query: 1227  DRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS 1286
                       + + ++  D   R  +   +++ S  L  + K   Y+             
Sbjct: 23172 ---------VITWSKQGIDLASRAII---DTTESYSLLIVDKVNRYDAGKYTIEAENQSG 23219

Query: 1287  PSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTAN 1346
                  +L +  D  PGP   +   EV   SV + W+ P    G  +   I  +       
Sbjct: 23220 KKSATVLVKVYD-TPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEKREAAMRA 23278

Query: 1347  TATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEA--LVVTTEKRDRPQPPS 1404
               TV     S   Y  +GL   ++Y FR+  +   G GE  E    V+ +E    P  P+
Sbjct: 23279 FKTVTTKC-SKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEV---PLVPA 23334

Query: 1405  RPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIV 1463
             +  ++  DV   +V L+WE P  DG S +  Y ++  +  + RW +   ++        V
Sbjct: 23335 K--LEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERW-MKVVTLKPTVLEHTV 23391

Query: 1464  DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-LSVTPHTTTSVLIRW 1522
               L     Y FR++A N+ G SE  E   ++T         PTI LS  P  T  V    
Sbjct: 23392 TSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRV--LPTIDLSTMPQKTIHV---- 23445

Query: 1523  QPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLT 1582
               PA   +  ++                   + G   P A+W    S   +R   R ++ 
Sbjct: 23446 --PAGRPVELVI------------------PIAGRPPPAASWFFAGS--KLRESERVTVE 23483

Query: 1583  QYELDNLNKHRRYEIRMSVYNAVGE---------GPSSPPQEVFV-GEAVPTAAPRNVVV 1632
              +      K  +  IR +     GE         G +S   +V +  +  P   P  + +
Sbjct: 23484 TH-----TKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP--IKI 23536

Query: 1633  HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG 1692
                 AT + ++WEPP LD     + GY +   +A R       +++    ++ K   LT 
Sbjct: 23537 DEIDATSITISWEPPELDG-GAPLSGYVVEQRDAHRPGWLPVSESV--TRSTFKFTRLTE 23593

Query: 1693  YTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFP 1750
                Y+  VAA N  G G   +S   + ++    P  P +++  +++   + ++W  P+  
Sbjct: 23594 GNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDD 23653

Query: 1751  NGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGP 1810
              G                 V+  +    +  +  W++V  +   +T   R R+   T G 
Sbjct: 23654 GG---------------SQVTGYIVERKEVRADRWVRVNKVPVTMT---RYRSTGLTEGL 23695

Query: 1811  EIEANVTT--GPGEGAPGPPGVPIIVR-----------------YSSAIAIHWS-SGDPG 1850
             E E  VT     G G P  P  PI+                     +++++ WS   D G
Sbjct: 23696 EYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEG 23755

Query: 1851  KGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGT 1910
                +T Y+IE +  D+  W       P ++  YT +   L  G  Y FRV+A N  G G 
Sbjct: 23756 GSKVTGYLIEMQKVDQHEWT-KCNTTPTKIREYTLTH--LPQGAEYRFRVLACNAGGPGE 23812

Query: 1911  PSSPSQSV--------PAQKANPFYEEWWFLVVIALVGLIFILLLVFVLIIRGQSKKYAK 1962
             P+    +V        P  + +  Y+E  F+    ++ L         + I+G+     K
Sbjct: 23813 PAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRL--------TIPIKGKPFPICK 23864

Query: 1963  KTDSGNSAKSGAL-----GHSEMMSLD----ESSFPALELNNRRLSVKNSFCRKNGLYTR 2013
              T  G      A+      H+E++  +    +S    L L N+        C K  +Y +
Sbjct: 23865 WTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDLVLENK--------CGKKAVYIK 23916

Query: 2014  SPPRPSPGSLHYSDEDVTKYNDLIPAESSSLTEKPSEISDSQGSDSEYEVDSNHQKAHSF 2073
                  SP     S E   +Y+D I   S  ++ +P   +D  G+D            +  
Sbjct: 23917 VRVIGSPN----SPEGPLEYDD-IQVRSVRVSWRPP--ADDGGADI---------LGYIL 23960

Query: 2074  VNHYISDPTYYNSWRRQQ------KGISRAQAYSYTESDSGEPDHTTVTNSTSTQQGSLF 2127
                 +    +Y    R +      KG+     Y +  S              +  Q  + 
Sbjct: 23961 ERREVPKAAWYTIDSRVRGTSLVVKGLKENVEYHFRVS--------------AENQFGIS 24006

Query: 2128  RPKASRTP----TPQNPPNPPS 2145
             +P  S  P    TP NPP PPS
Sbjct: 24007 KPLKSEEPVTPKTPLNPPEPPS 24028



 Score =  213 bits (541), Expect = 2e-54
 Identities = 413/1864 (22%), Positives = 693/1864 (37%), Gaps = 243/1864 (13%)

Query: 147  WFRDGRKIPPSSRIAITLEN---TLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPITLTV 203
            WFR+   I  SS+  I  ++   TL I      D   Y V   N +  + K++  + +  
Sbjct: 6367 WFRNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEE 6426

Query: 204  ENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV------L 257
            E++          I+ P K+   +   S VT  C  N    + + + W K+G        
Sbjct: 6427 EDL---------RIVEPLKDIETMEKKS-VTFWCKVNR---LNVTLKWTKNGEEVPFDNR 6473

Query: 258  LSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPP-QFVKEPER 316
            +S  +  +   LTI +    D G Y    ++ +    SV   A L ++E P +FV+  E 
Sbjct: 6474 VSYRVDKYKHMLTIKDCGFPDEGEY----IVTAGQDKSV---AELLIIEAPTEFVEHLED 6526

Query: 317  HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQ---ISGLVPD 373
                E +  V   CQ       ++ WY++    E+++  +++   DG +    I     D
Sbjct: 6527 QTVTEFDDAV-FSCQLSR-EKANVKWYRNGR--EIKEGKKYKFEKDGSIHRLIIKDCRLD 6582

Query: 374  DTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAI 433
            D   + C   +     +    L V  I   I R P D     G  VV   E +   +  +
Sbjct: 6583 DECEYACGVEDRKSRAR----LFVEEIPVEIIRPPQDILEAPGADVVFLAELN-KDKVEV 6637

Query: 434  TWQKGERILASGSVQLPRFTPLESGS---LLISPTHISDAGTYTCLATNSRGVDEASADL 490
             W +   ++  G     +   +  G    L I      D G Y  +A +     EA A L
Sbjct: 6638 QWLRNNMVVVQGD----KHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK----EARAKL 6689

Query: 491  VVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDR 550
             + A  +I    QD  V  G   +MV  V +D        W K+   L T++        
Sbjct: 6690 ELAAAPKIKTADQDLVVDVGKPLTMV--VPYDAYPKAEAEWFKENEPLSTKTIDTTA--E 6745

Query: 551  NGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVER--RAI 608
              S  I +   GD G Y   + +  G      +L+V  +P     PV  L   E     +
Sbjct: 6746 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPG----PVRNLEVTETFDGEV 6801

Query: 609  NLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPAR-SYQFRLC 666
            +L W +P  DG S +I Y++E  +     T +LA+   ++   TV GL      Y FR+ 
Sbjct: 6802 SLAWEEPLTDGGSKIIGYVVERRDIKRK-TWVLATDRAESCEFTVTGLQKGGVEYLFRVS 6860

Query: 667  AVNDVGKGQ-FSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKG 725
            A N VG G+    D    +  +     PP NV  +      + + W+ PPE      +  
Sbjct: 6861 ARNRVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWE-PPEYDGGAEITN 6919

Query: 726  YIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEW 785
            Y+I        + +       A+  +  + D++    Y   V A N  G+G   S  T +
Sbjct: 6920 YVIE-LRDKTSIRWDTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVG-KPSAATPF 6977

Query: 786  TLQGVP---TVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTM 842
                 P     PP N+ +     ++++  W  P        + G  ++ +  E+ EE   
Sbjct: 6978 VKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLK------DGGSPILGYIIERCEEGKD 7031

Query: 843  VTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHL 901
               R N +    + + V+GL+K  +Y   V      G         V    ++ GP+   
Sbjct: 7032 NWIRCNMKLVPELTYKVTGLEKGNKYLYRVSAENKAG---------VSDPSEILGPL--T 7080

Query: 902  SFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLE----YRVTG 957
            +    ++ ++ +S  + G +  +     I            T    +  LE     ++  
Sbjct: 7081 ADDAFVEPTMDLSAFKDGLEVIVPNPITILVPSTGYPRPTATWCFGDKVLETGDRVKMKT 7140

Query: 958  LTALTTYTIEVAAMTSKG----QGQVSASTISSGVPPEL---PGPPTNLGISNIGPRSVT 1010
            L+A     I  +  + KG    + +    TIS  +   +   P  P  L   +I   SV 
Sbjct: 7141 LSAYAELVISPSERSDKGIYTLKLENRVKTISGEIDVNVIARPSAPKELKFGDITKDSVH 7200

Query: 1011 LQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSF 1069
            L +  P  DG + ++ ++VE +       + W  +     + +     VPDL     Y F
Sbjct: 7201 LTWEPPDDDGGSPLTGYVVEKR---EVSRKTWTKVMDFVTDLE---FTVPDLVQGKEYLF 7254

Query: 1070 RMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNG 1127
            ++   N  G   P+     +   T    PD  P NV  R  +  S++L W P    + +G
Sbjct: 7255 KVCARNKCGPGEPAYVDEPVNMSTPATVPD-PPENVKWRDRTANSIFLTWDP---PKNDG 7310

Query: 1128 NPESVGYKIKY--SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG--- 1182
                 GY ++     SD        V + ++E    +  LEE   Y  +V+A N  G   
Sbjct: 7311 GSRIKGYIVERCPRGSDKWVACGEPVAETKME----VTGLEEGKWYAYRVKALNRQGASK 7366

Query: 1183 -SGPWSQTVVGRTRE--------------SVPSSGPTNVSALATTSSSMLVRWSEVPEAD 1227
             S P  +     T+E              +V +     + A  T      + W++     
Sbjct: 7367 PSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKA---- 7422

Query: 1228 RNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 1287
               ++L        ++   +    +V+   S +      G Y++  V V           
Sbjct: 7423 --DMILKQDKRITIENVPKKSTVTIVDSKRSDT------GTYIIEAVNVCG--------- 7465

Query: 1288 SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILA----------YQIT 1337
                ++E  + D PGPP      +V   S  L W PP    G  +            ++ 
Sbjct: 7466 RATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVW 7525

Query: 1338 HRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKR 1397
            H+L++T  +T            + AT L P   Y+FR+ A+   G GE  +A  +T + +
Sbjct: 7526 HKLSSTVKDT-----------NFKATKLIPNKEYIFRVAAENMYGVGEPVQASPITAKYQ 7574

Query: 1398 -DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVS 1455
             D P PP+R  ++  D+   +V L+W EP  DG SP+  Y ++  +  + +W +    + 
Sbjct: 7575 FDPPGPPTR--LEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDTDKW-VRCNKMP 7631

Query: 1456 HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA----PDEAPTILSVT 1511
               +++ V  L     Y+FRV A N  G  + S+ +E +          P   PT+  V 
Sbjct: 7632 VKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTVKDV- 7690

Query: 1512 PHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMY 1571
                TSV + W  P  D       G +I            + +  +      W       
Sbjct: 7691 --GKTSVRLNWTKPEHDG------GAKI----------ESYVIEMLKTGTDEW------- 7725

Query: 1572 SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSPPQEVFVGEAV-PTAAPRN 1629
             +R       TQ+ L  L + + Y  R+   N  GE  PS P   V   E + P + PR 
Sbjct: 7726 -VRVAEGVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRW 7784

Query: 1630 VVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKN 1689
            + V   T    D+ W  P  D     I  Y +   + +R    + V T  + +    +  
Sbjct: 7785 LEVINITKNTADLKWTVPEKDG-GSPITNYIVEKRDVRRKG-WQTVDTT-VKDTKCTVTP 7841

Query: 1690 LTGYTAYMVSVAAFNAAGDGPRS---TPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEA 1746
            LT  + Y+  VAA NA G    +        +     P  P ++   ++T   V++ WE 
Sbjct: 7842 LTEGSLYVFRVAAENAIGQSDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEP 7901

Query: 1747 PQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTF 1806
            P+   G     R V E    +   ++ V            +V D+ EG   +F++RA+  
Sbjct: 7902 PKNDGG-RPIQRYVIEKKERLG--TRWVKAGKTAGPDCNFRVTDVIEGTEVQFQVRAENE 7958

Query: 1807 TYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSA----IAIHWSSGDP-GKGPITRYVIEA 1861
                           E    PP  P+ +  + A    IAI W   +  G  PI  Y +E 
Sbjct: 7959 AGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEM 8018

Query: 1862 RPSDEGLWDIL----IKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQS 1917
             P     W  +    IKD+  +V       + + P   Y  RV AVN  G   PS  S++
Sbjct: 8019 CPVGTEKWMRVNSRPIKDLKFKVE------EGVVPDKEYVLRVRAVNAIGVSEPSEISEN 8072

Query: 1918 VPAQ 1921
            V A+
Sbjct: 8073 VVAK 8076



 Score =  213 bits (541), Expect = 2e-54
 Identities = 357/1619 (22%), Positives = 619/1619 (38%), Gaps = 152/1619 (9%)

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQ--TSTYLAVTSI----APNITRGPLDSTVI---DGM 417
             +SGLV D    F+  ARNAAG     + +  A+T+     APN +  P    VI    G 
Sbjct: 18359 VSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASLDPKYKDVIVVHAGE 18418

Query: 418   SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
             + VL  +  G P P + W K  + L   + ++   + ++  +L++     +D G Y    
Sbjct: 18419 TFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILKL 18478

Query: 478   TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVT------IRYIW 531
             +N  G       + V  R     PP+    + G  A   C +  +P +         YI 
Sbjct: 18479 SNVGGTKSIPITVKVLDRPG---PPEGPLKVTGVTAEK-CYLAWNPPLQDGGANISHYII 18534

Query: 532   EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG----GNDSRSAHLRVR 587
             EK   +  + +     +    +L+   T       Y  RV++      G    S  +   
Sbjct: 18535 EKRETSRLSWTQVSTEVQ---ALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTAC 18591

Query: 588   QLPHAPEHPVAT--LSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLASVD 644
               P+ P  P +T  +S + + ++ +TW +P D G + +  YILE  +             
Sbjct: 18592 N-PYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKT 18650

Query: 645   PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP-PTAPPQNVIASGRT 703
                  + V GL    SY+FR+ A N  G G+ S+ +      +   P  PP N   +  +
Sbjct: 18651 LTDLRLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTS 18710

Query: 704   NQSIMIQWQPPPESHQNGI-LKGYIIRYCLAGL--------PVGYQFKNITDADVNNLLL 754
               S+ + W  P   +  G  +KGY++    A          P G Q K  T   +     
Sbjct: 18711 RSSVSLAWSKP--IYDGGAPVKGYVVEVKEAAADEWTTCTPPTGLQGKQFTVTKLKEN-- 18766

Query: 755   EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNA 814
                   T Y   + A NS G+G  ++       Q    + P  +  +A     +    +A
Sbjct: 18767 ------TEYNFRICAINSEGVGEPATLPGSVVAQ--ERIEPPEIELDADLRKVVVLRASA 18818

Query: 815   PSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCF 874
                 F+    +    + WE  + E +    A+     S  +  +  + +F     ++   
Sbjct: 18819 TLRLFVTIKGRPEPEVKWE--KAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLE 18876

Query: 875   TTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWE 933
                G   ++    VR  +    PV +L+  E+   S+ +SW+ P    G  +T Y +   
Sbjct: 18877 NNSGS--KTAFVNVRVLDSPSAPV-NLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKR 18933

Query: 934   EYNR-TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992
             E  R     +T+     T  +R+  L    +Y   V A    G G + A T       E 
Sbjct: 18934 ETTRKAYATITNNCTKTT--FRIENLQEGCSYYFRVLASNEYGIG-LPAETTEPVKVSEP 18990

Query: 993   PGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
             P PP  + + ++   + T+++ +P  DG + I+ ++VE Q       E+W    Q+    
Sbjct: 18991 PLPPGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTK---GSEKWSTCTQVKT-- 19045

Query: 1052  DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPANVSLRTAS 1109
                   +  L     Y FR+  VN  G S P Q    +  + ++  P +     +    +
Sbjct: 19046 --LEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKA 19103

Query: 1110  ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWT 1169
                L +      ++ + G P++    + + +    G+TL    +  V    T+  L    
Sbjct: 19104 REQLKI------DVPFKGRPQAT---VNWRKD---GQTLKETTRVNVSSSKTVTSLSIKE 19151

Query: 1170  EYRVQVQAF-----NAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVP 1224
               +  V  +     N+ GS     T++   R   P  GP  +  ++    S+ + W+  P
Sbjct: 19152 ASKEDVGTYELCVSNSAGSITVPITIIVLDRPGPP--GPIRIDEVSC--DSITISWNP-P 19206

Query: 1225  EADRNGLVLGYKVMYKEKDSDTQPRFWLV--EGNSSRSAQLTGLGKYVLYEVQVLAFTRI 1282
             E D    +  Y V  KE  S T    W +  +  +  S ++  L     Y+ +V A  R 
Sbjct: 19207 EYDGGCQISNYIVEKKETTSTT----WHIVSQAVARTSIKIVRLTTGSEYQFRVCAENRY 19262

Query: 1283  GDGSPSHPP-ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQITHRL 1340
             G  S S    ++       PGPP          +++ + WQ P    G  ++ Y + ++ 
Sbjct: 19263 GKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKE 19322

Query: 1341  NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRP 1400
              ++   +   ++L     Q   +GL    +Y +R+ A+   G G+ +++       RD  
Sbjct: 19323 RSSILWSKANKILIADT-QMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCE-PVPARDPC 19380

Query: 1401  QPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNAS 1459
              PP +P V   ++  +SV L W +P  DG + +  Y ++ RELP GRW L     +   +
Sbjct: 19381 DPPGQPEVT--NITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRW-LKCNYTNIQET 19437

Query: 1460  SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVL 1519
              F V  L     Y+FRV A N       SE SES   +    D  P  + +       ++
Sbjct: 19438 YFEVTELTEDQRYEFRVFARN--AADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIV 19495

Query: 1520  IRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRP 1579
             ++       KIN  + G   R   ++     G  +           +  ++ ++++  R 
Sbjct: 19496 VKAGEVL--KINADIAG---RPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRR 19550

Query: 1580  SLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQ 1639
                QY L   N      + ++       GP + P E+                +G TA +
Sbjct: 19551 DTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEI----------------NGLTAEK 19594

Query: 1640  LDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVS 1699
               ++W  P  D    DI  Y +   + +  +L   +    L   S K+  L     Y+  
Sbjct: 19595 CSLSWGRPQEDG-GADIDYYIVE--KRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFR 19651

Query: 1700  VAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEG 1756
             V   N  G G    S   +       PS P+S++ + +T  S+ + W  P+   G  + G
Sbjct: 19652 VTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISG 19711

Query: 1757  YRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT---FTYGPEIE 1813
             Y +     + +    + V V+ K    L +K   L EG  Y +R+ A+     +   E  
Sbjct: 19712 YIIERREKNSL----RWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETS 19767

Query: 1814  ANVTTGPGEGAPGPPGVPIIVRYS-SAIAIHWSSG-DPGKGPITRYVIEARPSDEGLWDI 1871
               +        P PP  P IV    + I I W      G  PIT Y +E + SD+  W  
Sbjct: 19768 PLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKT 19827

Query: 1872  LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPS--QSVPAQKANPFYE 1928
              I+ +    + YT S   L  G  Y FRV +VN  G   PS  S  Q    ++  P ++
Sbjct: 19828 SIQSL--RGTEYTISG--LTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFD 19882



 Score =  211 bits (538), Expect = 5e-54
 Identities = 373/1635 (22%), Positives = 612/1635 (37%), Gaps = 185/1635 (11%)

Query: 361   NDGGLQISGLVPDDTGMFQCFARNAAGEVQ-----TSTYLAVTSIAPNITRGPLDS---- 411
             +D    ++ L   DT  F+  A+NAAG +      T         AP   +  LD+    
Sbjct: 22692 SDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAP--PKAELDARLHG 22749

Query: 412   ---TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHIS 468
                T+  G  +VL     G P P I W KG++ L        ++T  +  + +I     S
Sbjct: 22750 DLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTG-KRATAVIKFCDRS 22808

Query: 469   DAGTYTCLATNSRGVDEASADLVVW------ARTRITKPPQDQSVIKGT--QASMVCGVT 520
             D+G YT    N+ G    S  + V        +  +++  Q++  +  +  Q      +T
Sbjct: 22809 DSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEIT 22868

Query: 521   H---DPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG-- 575
             H   + R T R  W        T S+   RL +N               Y  RV +    
Sbjct: 22869 HYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNE-------------YIFRVRAVNKY 22915

Query: 576   --GNDSRSAHLRVRQ---LPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEM 629
               G    S  +  R    +P  P  P    +  E   I + WTKP  DG + +  Y+++ 
Sbjct: 22916 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEH--IIIQWTKPESDGGNEISNYLVDK 22973

Query: 630   SENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEE 688
              E  +  WT +        T + V  L+    YQFR+ AVN  G  + S+ +  +S  E 
Sbjct: 22974 REKKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREP 23033

Query: 689   PPT-APPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDA 747
               T  PP        T  SI + W  P       I+ GY++          Y+    T+A
Sbjct: 23034 SYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIV-GYVLEMQEKDTDQWYRVH--TNA 23090

Query: 748   DVNN--LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNS 805
              + N    + DL +   Y   VAA N  G+  YS  + E        +P   +  +   +
Sbjct: 23091 TIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKT 23150

Query: 806   TTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFT 865
              TIR    A     ++   +   +I W  +  +  +          S+ +     + K  
Sbjct: 23151 VTIRA--GASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLI-----VDKVN 23203

Query: 866   EYFTSVLCFTTPGD-GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI 924
              Y             G +S   LV+ + D PGP   +   E+   S+ ++W+ P    G 
Sbjct: 23204 RYDAGKYTIEAENQSGKKSATVLVKVY-DTPGPCPSVKVKEVSRDSVTITWEIPTIDGGA 23262

Query: 925   -LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAST 983
              +  Y +   E      +      + TL YR++GL   T Y   V      G G+    T
Sbjct: 23263 PVNNYIVEKREAAMRAFKTVTTKCSKTL-YRISGLVEGTMYYFRVLPENIYGIGE-PCET 23320

Query: 984   ISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEA-QVGVVGEGEEW 1041
               + +  E+P  P  L + ++   +VTL + +P YDG + ++ +++EA + G     E W
Sbjct: 23321 SDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGT----ERW 23376

Query: 1042  LLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP--SRKIQTLQAPPDMA 1099
             + +  L  +P      V  LN    Y FR+R  N  G S P +   +  +Q L+  P + 
Sbjct: 23377 MKVVTL--KPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTID 23434

Query: 1100  PANVSLRTAS-------ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRS---DGHGKTLS 1149
              + +  +T         E  + +   P P   +       G K++ S     + H K   
Sbjct: 23435 LSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWF----FAGSKLRESERVTVETHTKVAK 23490

Query: 1150  HVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSAL 1209
               +     R+ TI D  E+T     ++  N  G+   +  V+   +   P +GP  +  +
Sbjct: 23491 LTI-----RETTIRDTGEYT-----LELKNVTGTTSETIKVIILDKPG-PPTGPIKIDEI 23539

Query: 1210  ATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGK 1268
               TS  + + W E PE D    + GY V   E+    +P +  V  + +RS  + T L +
Sbjct: 23540 DATS--ITISW-EPPELDGGAPLSGYVV---EQRDAHRPGWLPVSESVTRSTFKFTRLTE 23593

Query: 1269  YVLYEVQVLAFTRIGDGSPSHPPILE-RTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAP 1327
                Y  +V A  R G GS     ++E R+   +PGPP  +   +V    + L W PP   
Sbjct: 23594 GNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYPPEDD 23653

Query: 1328  NGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAA 1387
              G  +   I  R          V  +  +  +Y +TGL     Y  R+TA   +G G+ +
Sbjct: 23654 GGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPS 23713

Query: 1388  EAL--VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPS 1444
                  +V  +    P  P  P V   D    SV L+W  P  +G S V  Y I+ +++  
Sbjct: 23714 RPSKPIVAMDPIAPPGKPQNPRV--TDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQ 23771

Query: 1445  GRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA 1504
               W   + + +     + +  L     Y+FRV A N  G  E              P E 
Sbjct: 23772 HEWTKCNTTPT-KIREYTLTHLPQGAEYRFRVLACNAGGPGE--------------PAEV 23816

Query: 1505  PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRG-----FTLRGINN 1559
             P  + VT       ++ +     D+          RY+E ++    G       ++G   
Sbjct: 23817 PGTVKVTE------MLEYPDYELDE----------RYQEGIFVRQGGVIRLTIPIKGKPF 23860

Query: 1560  PGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVG 1619
             P   W +     S R +   S T  EL      R        Y+ V E      + V++ 
Sbjct: 23861 PICKWTKEGQDISKRAMIATSETHTELVIKEADRG---DSGTYDLVLENKCG-KKAVYIK 23916

Query: 1620  EAV---PTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRG---NLTE 1673
               V   P +    +         + V+W  PP D    DI GY +   E  +     +  
Sbjct: 23917 VRVIGSPNSPEGPLEYDDIQVRSVRVSWR-PPADDGGADILGYILERREVPKAAWYTIDS 23975

Query: 1674  RVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDG---PRSTPTQGQTQQAAPSAPSS- 1729
             RV+       S+ +K L     Y   V+A N  G         P   +T    P  PS+ 
Sbjct: 23976 RVR-----GTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNP 24030

Query: 1730  VKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKV 1788
              +  ++T +SV++SW  P+   G  + GY +  +  S      K V  +    +     V
Sbjct: 24031 PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETS----TDKWVRHNKTQITTTMYTV 24086

Query: 1789  KDLAEGVTYRFRIRAKT----FTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHW 1844
               L     Y+FRI A+         P  E  V   P +    P  + I+     ++ + W
Sbjct: 24087 TGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQW 24146

Query: 1845  SSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAV 1903
                +  G   I  Y +E R S +  W    K   + +    F++  L     Y+FRV A 
Sbjct: 24147 EKPECDGGKEILGYWVEYRQSGDSAWK---KSNKERIKDKQFTIGGLLEATEYEFRVFAE 24203

Query: 1904  NDYGFGTPSSPSQSV 1918
             N+ G   P   + S+
Sbjct: 24204 NETGLSRPRRTAMSI 24218



 Score =  211 bits (537), Expect = 6e-54
 Identities = 408/1878 (21%), Positives = 683/1878 (36%), Gaps = 218/1878 (11%)

Query: 136   RIASFPQPQVTWFRDGRKIPPSSRIAITLE---NTLVILSTVAPDAGRYYVQAVNDKNGD 192
             R+   P+P +TW ++G+ +    R+ +  +     L I   V  D G+Y + A   KN  
Sbjct: 11626 RVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISA---KNSS 11682

Query: 193   NKTSQPITLTVENVGGPADPIAPTIIIPPKNT-----SVVAGTSEVTLECVANARPLIKL 247
                     + V +  GP   +  T +     T      +  G SE+T   V   +P  K 
Sbjct: 11683 GHAQGSAIVNVLDRPGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYRKPNQK- 11741

Query: 248   HIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEP 307
                W       S   SD  +RL   N   ++  Y+   A  +    P++     +  + P
Sbjct: 11742 --GW-------SIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPILAINP 11792

Query: 308   PQFVKEPER-HITAEMEKVVDIPCQAKGVP--PPSITWYKDAAVVEVEKLTRFRQRN--D 362
                  EPE  HI  + +  V +  +        P+++++ +  +   +   R  + +  +
Sbjct: 11793 IDRPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIKE 11852

Query: 363   GGLQISGLVPDDTGMFQCFARNAAGE---VQTSTYLAVTSIAPNITRGPLDS--TVIDGM 417
                 +   V +    F+   +N  GE   V+T   +    +   +    L    TV  G 
Sbjct: 11853 THYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGD 11912

Query: 418   SVVLACETSGAPRPAITWQKGERILASGSVQLPRF---TPLESGSLLISPTHISDAGTYT 474
             ++ L     G P P + W K +   A+   + PR    T  +S    ++    SD G Y 
Sbjct: 11913 TIRLEAGVRGKPFPEVAWTKDKD--ATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 11970

Query: 475   CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPR---------- 524
               ATN+ G   A A + V     + KP   +++     +S  C V  DP           
Sbjct: 11971 VTATNTAGSFVAYATVNV-----LDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQN 12025

Query: 525   ------VTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGND 578
                    T R +W    AT+ T      RL               IGT           +
Sbjct: 12026 YILEKCETKRMVWSTYSATVLTPGTTVTRLIEGNEYIFRVRAENKIGT-------GPPTE 12078

Query: 579   SRSAHLRVR-QLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP- 635
             S+    + +   P  P+ P  T   V +  + + W  P +DG   +  Y LE  E ++  
Sbjct: 12079 SKPVIAKTKYDKPGRPDPPEVT--KVSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTR 12136

Query: 636   WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL--PEEPPTAP 693
             W  +  S  P+   + V+ L+P   YQFR+ A N++G G+ S  +  V    P EPP  P
Sbjct: 12137 WVPVNKSAIPE-RRMKVQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPP-GP 12194

Query: 694   PQNVIASGRTNQSIMIQWQPPPESHQNGILKGYII---------------RYCLAGLPVG 738
             P N      T  SI + W  P       I+ GY++               + C A   + 
Sbjct: 12195 PTNFRVVDTTKHSITLGWGKPVYDGGAPII-GYVVEMRPKIADASPDEGWKRCNAAAQLV 12253

Query: 739   YQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNV 798
              +   +T  D N            YE  V A N  G+G   +++ E  ++    + P  +
Sbjct: 12254 RKEFTVTSLDENQ----------EYEFRVCAQNQVGIG-RPAELKE-AIKPKEILEPPEI 12301

Query: 799   HAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFV 858
               +A+    +      P   F     +    + W     + V     R    D +     
Sbjct: 12302 DLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNV----VRKGQVDLVDTMAF 12357

Query: 859   SGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEP 918
               +   T   +     T           +     D PGPV  L  S++  TS  VSW  P
Sbjct: 12358 LVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDTPGPVSDLKVSDVTKTSCHVSWAPP 12417

Query: 919   GEKNGI-LTGYRISWEEYNR-TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQ 976
                 G  +T Y +   E +R T + VT  +   +  + VT L     Y   V A+   G 
Sbjct: 12418 ENDGGSQVTHYIVEKREADRKTWSTVTPEVKKTS--FHVTNLVPGNEYYFRVTAVNEYGP 12475

Query: 977   GQVS--ASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKTSISRWLV--EAQ 1031
             G  +     + +  P   P PP  L ++ +   S TL + P   DG   I  ++     +
Sbjct: 12476 GVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREE 12535

Query: 1032  VGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPS---RK 1088
                     E+ ++  L       S+ V  L     Y FR+   N VG S P +       
Sbjct: 12536 EQPADRWTEYSVVKDL-------SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEA 12588

Query: 1089  IQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTL 1148
              + L  P  + P  ++++   +  +        E    G P       K+ + +    T 
Sbjct: 12589 KEQLLPPKILMPEQITIKAGKKLRI--------EAHVYGKPHPT---CKWKKGEDEVVTS 12637

Query: 1149  SHVVQDRVERD--YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNV 1206
             SH+   + +      I+D+         + A N+ G+      VV       P   P ++
Sbjct: 12638 SHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPG-PPQPPFDI 12696

Query: 1207  SALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWL-----VEGNSSRSA 1261
             S +   + S+   W  +P  D    +  Y V    +  D     W+     V   S R  
Sbjct: 12697 SDIDADACSL--SW-HIPLEDGGSNITNYIV----EKCDVSRGDWVTALASVTKTSCRVG 12749

Query: 1262  QLTGLGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLI 1320
             +L    +Y+    +V A  R G   P + P ++ +    VP  P      +V    + + 
Sbjct: 12750 KLIPGQEYIF---RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVA 12806

Query: 1321  WQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQT 1379
             W  P +  G  I+ Y I  +   +       + L  S  +Y   GL     Y FRI A  
Sbjct: 12807 WDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRST-EYPCAGLVEGLEYSFRIYALN 12865

Query: 1380  RKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQ 1438
             + G    ++     T  R    PP +P V   DV   +V L W  P  DG S +  Y ++
Sbjct: 12866 KAGSSPPSKPTEYVT-ARMPVDPPGKPEV--IDVTKSTVSLIWARPKHDGGSKIIGYFVE 12922

Query: 1439  TRELPSGRWA-LHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTL 1497
               +LP  +W   ++A        +    L+    Y+FR  A   +  S  SE S+ +T L
Sbjct: 12923 ACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISPPSEPSDPVTIL 12982

Query: 1498  QAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGI 1557
                        +V P    SV ++     +   N  L                  T+ G 
Sbjct: 12983 AE---------NVPPRIDLSVAMKSLLTVKAGTNVCL----------------DATVFGK 13017

Query: 1558  NNPGATWAE----LTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPP 1613
               P  +W +    L     ++   + +L   EL ++N+    +  ++  N+ G   ++  
Sbjct: 13018 PMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIK 13077

Query: 1614  QEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTE 1673
              +V          P +V ++   + +  ++WE PPL+    +I  Y +   E  R N  +
Sbjct: 13078 LKVL----DKPGPPASVKINKMYSDRAMLSWE-PPLEDGGSEITNYIVDKRETSRPNWAQ 13132

Query: 1674  RVKTLFLAENSVKLKNLTGYTAYMVSVAAFN--AAGDGPRSTPTQGQTQQAAPSAPSSVK 1731
                T+ +   SV+ K + G+  Y   + A N    GD   + P   +     P       
Sbjct: 13133 VSATVPITSCSVE-KLIEGH-EYQFRICAENKYGVGDPVFTEPAIAKNPYDPPGRCDPPV 13190

Query: 1732  FSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKD 1790
              S +T   + VSW+ P    G  + GY L       V+       V+ K      LK   
Sbjct: 13191 ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTK----VNRKPIIERTLKATG 13246

Query: 1791  LAEGVTYRFRIRAKTFTYGPEIEANVTTG----PGEGAPGPPGVPIIVRYS-SAIAIHWS 1845
             L EG  Y FR+ A     GP   ++ +        +  PGPP  P +   + S++++ W 
Sbjct: 13247 LQEGTEYEFRVTAIN-KAGPGKPSDASKAAYARDPQYPPGPPAFPKVYDTTRSSVSLSW- 13304

Query: 1846  SGDP---GKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
              G P   G  PI  Y++E + +D   W  +  ++P+ +    F +  L     Y FRV A
Sbjct: 13305 -GKPAYDGGSPIIGYLVEVKRADSDNW--VRCNLPQNLQKTRFEVTGLMEDTQYQFRVYA 13361

Query: 1903  VNDYGFGTPSS-PSQSVP 1919
             VN  G+  PS  P +  P
Sbjct: 13362 VNKIGYSDPSDVPDKHYP 13379



 Score =  211 bits (537), Expect = 6e-54
 Identities = 342/1451 (23%), Positives = 555/1451 (38%), Gaps = 168/1451 (11%)

Query: 531   WEKDGATLGTESHPRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
             W K G  +      +I      S L I      D G YT    +  G       + V  +
Sbjct: 14108 WSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLDV 14167

Query: 590   PHAPEHPVATLSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAP-WTVLLASVDPKA 647
             P  P  PV  +S V      LTWT P  DG SP+  YILE  E +   WTV+  S D ++
Sbjct: 14168 P-GPPGPVE-ISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVV--SEDIQS 14223

Query: 648   TSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSI 707
                    L+    Y FR+ AVN  GKG+  +      +    P  PP+    S  T  + 
Sbjct: 14224 CRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTA 14283

Query: 708   MIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKN-ITDADVNNLLLEDLIIWTNYEIE 766
              + W+ P +   + I   ++ R     L      K  ++D       L++    + YE  
Sbjct: 14284 TVSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQE---GSTYEFR 14340

Query: 767   VAAYNSAGLGVYSSKVTEWTLQGV--PTVPPGNVHAEATNSTTIRFTWNAPSPQFINGIN 824
             V+A N AG+G  S       ++    P  PP N H   T   +    W  P        +
Sbjct: 14341 VSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPH------YD 14394

Query: 825   QGYKLIAWEPEQEEEVTMVTARPNFQDSIHVG--FVSGLKKFTEYFTSVLCFTTPGDGPR 882
              G ++  +  E ++       +     ++ +    V  L+   +Y   +      G G  
Sbjct: 14395 GGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEP 14454

Query: 883   STPQLVRTHEDVPGPVGHLSFSEILDT-------SLKVSWQEPGEKNGILTGYRISWEEY 935
             +    V   E    P   L  +E+  T       S+++     G     +T  + +    
Sbjct: 14455 AVIPDVEIVEREMAPDFELD-AELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLK 14513

Query: 936   NRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP 995
             NR N   T     + +       T     TIE  A   K  G V+   + +      PGP
Sbjct: 14514 NRANIENTESFTLLIIPECNRYDTGKFVMTIENPA--GKKSGFVNVRVLDT------PGP 14565

Query: 996   PTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDAR 1054
               NL  ++I   SVTL +  P  DG + I+ ++VE +                + +    
Sbjct: 14566 VLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKS------YSTATTKCHKC 14619

Query: 1055  SMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLW 1114
             + +V  L+    Y FR+   N  G   P++ +  ++  +AP    P ++++   +++++ 
Sbjct: 14620 TYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSP--PDSLNIMDITKSTVS 14677

Query: 1115  LRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQ 1174
             L W   P+ +++G  +  GY I+  R      T    V+     +  + +L E  EY  Q
Sbjct: 14678 LAW---PKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGL---ECVVRNLTEGEEYTFQ 14731

Query: 1175  VQAFNAIG-SGPW-SQTVVGRTRESVPS---SGPTNVSALATTSSSMLVRWSEVPEADRN 1229
             V A N+ G S P  S+ V+ + +  +P     G      +A    ++ V   E+P   R 
Sbjct: 14732 VMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKV---EIPVLGRP 14788

Query: 1230  GLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFT------RIG 1283
                + +K     K      +   V   ++ ++ +  + + V  +      T       +G
Sbjct: 14789 KPTVTWK-----KGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVG 14843

Query: 1284  DGSPSHPPILERTLDDVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNT 1342
             D       ++   + D+PGPP G I F EV +  V   W PP    G+ ++  +     T
Sbjct: 14844 D-------VITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQT 14896

Query: 1343  TTANTATVEVLAPSARQ-YTATGLKPESVYLFRITAQTRKGWGEA-AEALVVTTEKRDRP 1400
              +  T  VE+     R  Y AT L     Y FR+ AQ R G G     A +V       P
Sbjct: 14897 DS--TTWVELATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVP 14954

Query: 1401  QPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRW-ALHSASVSHNA 1458
              PP  P V    V   S+ +SW EP SDG SP+  Y ++ +E     W  +  A V  N 
Sbjct: 14955 GPPGTPQVTA--VTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNI 15012

Query: 1459  --SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA-PDEAPTILSVTPHTT 1515
               SS + D +    +Y+FRV A N  G S+ S+ SE +  L    P   P  L++T HT 
Sbjct: 15013 FKSSGLTDGI----AYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTV 15068

Query: 1516  TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
             T   ++W  P   +  G   GF+I            + +   + P   W +        N
Sbjct: 15069 T---LKWAKP---EYTG---GFKIT----------SYIVEKRDLPNGRWLKA-------N 15102

Query: 1576  LSRPSLTQYELDNLNKHRRYEIRMSVYNAVG--EGPSSPPQEVFVGEAVPTAAPR----- 1628
              S     ++ +  L +   YE R+   NA G    PS P   +   + V   AP+     
Sbjct: 15103 FSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVE--APKIKVDV 15160

Query: 1629  ----NVVVHGATATQL--DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
                  V++    A +L  DV+  PPP    + D         +   G     +K    + 
Sbjct: 15161 KFKDTVILKAGEAFRLEADVSGRPPPTMEWSKD--------GKELEGTAKLEIKIADFST 15212

Query: 1683  NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
             N V  K+ T   +   ++ A N  G        +   +   P  P +V  +E+T+    +
Sbjct: 15213 NLVN-KDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAV--TEVTSEKCVL 15269

Query: 1743  SWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLW-LKVKDLAEGVTYRFRI 1801
             SW  P    G    + +V +        S++   +V     +  LKV  L +G  Y FR+
Sbjct: 15270 SWFPPLDDGGAKIDHYIVQKR-----ETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRV 15324

Query: 1802  RA-KTFTYGPEIEANVTTGPGE-GAPGPPGVPIIVRYSS-AIAIHWSSGDP-GKGPITRY 1857
              A   +  G  +E+         G P PP  P +   +  ++ + W   D  G   I  Y
Sbjct: 15325 MAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINY 15384

Query: 1858  VIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQS 1917
             ++E R      W   IK   K ++   + +  L  G  Y+FR++A N  G   PS  S  
Sbjct: 15385 IVERRDKAGQRW---IKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTS-- 15439

Query: 1918  VPAQKANPFYE 1928
                    PFY+
Sbjct: 15440 -------PFYK 15443



 Score =  211 bits (537), Expect = 6e-54
 Identities = 438/1934 (22%), Positives = 700/1934 (36%), Gaps = 355/1934 (18%)

Query: 141   PQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRY----YVQAVNDKNGDNKTS 196
             P P+VTW +D   +   + I  T   TL+I+    P+  RY    +V  + +  G  K S
Sbjct: 14499 PAPEVTWTKDNINLKNRANIENTESFTLLII----PECNRYDTGKFVMTIENPAG--KKS 14552

Query: 197   QPITLTVENVGGPADPIAPTIIIPPKNT-----SVVAGTSEVTLECVANARPLIKLHIIW 251
               + + V +  GP   + PT I     T      ++ G S +T             +I+ 
Sbjct: 14553 GFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRIT------------NYIVE 14600

Query: 252   KKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFV 311
             K++    S   +           TG   G   CE   R  +      G      EP   V
Sbjct: 14601 KREATRKSYSTATTKCHKCTYKVTGLSEG---CEYFFRVMAENEYGIGEPTETTEP---V 14654

Query: 312   KEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLV 371
             K  E     +   ++DI          S+ W K               ++DGG +I+G V
Sbjct: 14655 KASEAPSPPDSLNIMDITKST-----VSLAWPK--------------PKHDGGSKITGYV 14695

Query: 372   PD-------------DTGMFQCFARN-AAGEVQTSTYLAVTS------------------ 399
              +                  +C  RN   GE  T   +AV S                  
Sbjct: 14696 IEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQT 14755

Query: 400   IAPNI-TRGPLDSTVI--DGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLE 456
             + P +  RG     VI   G ++ +     G P+P +TW+KG++IL     Q   F    
Sbjct: 14756 MLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILK--QTQRVNFETTA 14813

Query: 457   SGSLL-ISPTHISDAGTYTCLATNSRG----------------------VDEASADLVVW 493
             + ++L I+    SD+G Y   A N  G                       DE S+D V +
Sbjct: 14814 TSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTF 14873

Query: 494   ARTRITKPPQDQS-------VIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRI 546
             +      PP++         V++  Q      V     V IR  ++    T G E   R+
Sbjct: 14874 S----WDPPENDGGVPISNYVVEMRQTDSTTWVELATTV-IRTTYKATRLTTGLEYQFRV 14928

Query: 547   RLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERR 606
             +      +    T +  +  Y  +V                  P  P  P  T   V + 
Sbjct: 14929 KAQNRYGVGPGITSACIVANYPFKV------------------PGPPGTPQVT--AVTKD 14968

Query: 607   AINLTWTKPF-DGNSPLIRYILEMSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFR 664
             ++ ++W +P  DG SP++ Y +E  E N   W  +  ++ P        GL    +Y+FR
Sbjct: 14969 SMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVP-GNIFKSSGLTDGIAYEFR 15027

Query: 665   LCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI-L 723
             + A N  GK + SK +E +   +  P  PP   +    T  ++ ++W  P   +  G  +
Sbjct: 15028 VIAENMAGKSKPSKPSEPMLALD--PIDPPGKPVPLNITRHTVTLKWAKP--EYTGGFKI 15083

Query: 724   KGYIIRYCLAGLPVGYQFK-NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKV 782
               YI+      LP G   K N ++   N   +  L     YE  V A N+AG        
Sbjct: 15084 TSYIVE--KRDLPNGRWLKANFSNILENEFTVSGLTEDAAYEFRVIAKNAAG-------- 15133

Query: 783   TEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTM 842
                        PP    +E +++ T R    AP  +          L A E  + E    
Sbjct: 15134 --------AISPP----SEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGEAFRLEADVS 15181

Query: 843   VTARPNFQDSIHVGFVSGLK----KFTEYFTSVL----------CFTTPGDGPRSTPQLV 888
                 P  + S     + G      K  ++ T+++           +T     P    + +
Sbjct: 15182 GRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTATNPGGFAKHI 15241

Query: 889   RTHE--DVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTH 944
                +  D PG P G L+ +E+      +SW  P +  G  +  Y +   E +R       
Sbjct: 15242 FNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIVQKRETSRLAWTNVA 15301

Query: 945   YLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPTNLGISN 1003
                 VT + +VT L     Y   V A+   G G+ + +  + +  P   P PP N  ++ 
Sbjct: 15302 SEVQVT-KLKVTKLLKGNEYIFRVMAVNKYGVGEPLESEPVLAVNPYGPPDPPKNPEVTT 15360

Query: 1004  IGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLN 1062
             I   S+ + +  P  DG + I  ++VE +      G+ W+  ++     D R  +V  L 
Sbjct: 15361 ITKDSMVVCWGHPDSDGGSEIINYIVERRDKA---GQRWIKCNK-KTLTDLR-YKVSGLT 15415

Query: 1063  PFTCYSFRMRQVNIVGTSPPSQPS---RKIQTLQAPPDMAPANVSLRTASETSLWLRW-M 1118
                 Y FR+   N  G S PS  S   +   T+  P    P N  +   S +S+ + W  
Sbjct: 15416 EGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKPG--PPGNPRVLDTSRSSISIAWNK 15473

Query: 1119  PLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAF 1178
             P+    Y+G  E  GY ++ +  +     +           YTI  L E  EY++++ A 
Sbjct: 15474 PI----YDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAM 15529

Query: 1179  NAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVR---------------WSEV 1223
             N+ G G     +V  T ++     P  +   A     + +R                 EV
Sbjct: 15530 NSEGLG--EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEV 15587

Query: 1224  PEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG 1283
               A  +G     + + K     T     L+ GN +R       GKY+L          + 
Sbjct: 15588 KWARDHG-----ESLDKASIESTSSYTLLIVGNVNRFDS----GKYIL---------TVE 15629

Query: 1284  DGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTT 1343
             + S S    +   + D PGPP  +   EV  TSV L W PP    G  +   I  +  +T
Sbjct: 15630 NSSGSKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVEKREST 15689

Query: 1344  TANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPP 1403
                 +TV         +    L+    Y FR+ A+   G G  AE    + +  +RP PP
Sbjct: 15690 RKAYSTVATNCHKT-SWKVDQLQEGCSYYFRVLAENEYGIGLPAET-AESVKASERPLPP 15747

Query: 1404  SRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFI 1462
              +  +   DV   SV LSWE P  DG S +  Y ++ +   S +WA      +   +   
Sbjct: 15748 GK--ITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKWA---TCATVKVTEAT 15802

Query: 1463  VDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRW 1522
             +  L     Y FRV A N+ G S+                  P  LSV P     ++I  
Sbjct: 15803 ITGLIQGEEYSFRVSAQNEKGISD------------------PRQLSV-PVIAKDLVI-- 15841

Query: 1523  QPPAEDKINGILLGFRIRYRELLYEGLRGFTLR------GINNPGATW------AELTSM 1570
              PPA          F++ +    +  L G  L+      G   P  TW       + T+ 
Sbjct: 15842 -PPA----------FKLLFN--TFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTR 15888

Query: 1571  YSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNV 1630
              +  +    SL   +         Y ++++  N+ GE   +    V      PT     V
Sbjct: 15889 VNAESTENNSLLTIKDACREDVGHYVVKLT--NSAGEAIETLNVIVLDKPGPPTGP---V 15943

Query: 1631  VVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNL 1690
              +   TA  + ++W PP  D     I  Y +   +      T ++ +  +A  ++K   L
Sbjct: 15944 KMDEVTADSITLSWGPPKYDG-GSSINNYIVE--KRDTSTTTWQIVSATVARTTIKACRL 16000

Query: 1691  TGYTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQ 1748
                  Y   +AA N  G      S PT  Q     P  P +   +  +  S+ V W    
Sbjct: 16001 KTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVTLSSRDSMEVQWN--- 16057

Query: 1749  FPNGILEGYRLVYEPCSPVDGVSKIVTVDV---KGNSPLWLKVK------------DLAE 1793
                          EP S  DG S+++   +   + NS LW+K+              L E
Sbjct: 16058 -------------EPIS--DGGSRVIGYHLERKERNSILWVKLNKTPIPQTKFKTTGLEE 16102

Query: 1794  GVTYRFRIRAKTFT----YGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD- 1848
             GV Y FR+ A+            E  V   P +  PG P   I+ R  +++ + W     
Sbjct: 16103 GVEYEFRVSAENIVGIGKPSKVSECYVARDPCD-PPGRPEAIIVTR--NSVTLQWKKPTY 16159

Query: 1849  PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG- 1907
              G   IT Y++E +   EG W   +K     +    F +  L     Y+FRVIA N  G 
Sbjct: 16160 DGGSKITGYIVEKKELPEGRW---MKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGV 16216

Query: 1908  FGTPSSPSQSVPAQ 1921
             F  PS  + ++ A+
Sbjct: 16217 FSEPSESTGAITAR 16230



 Score =  210 bits (535), Expect = 1e-53
 Identities = 345/1488 (23%), Positives = 556/1488 (37%), Gaps = 155/1488 (10%)

Query: 506  SVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIR-LDRNGSLHISQTWSGDI 564
            +V  GT+  +   VT  P   I   W K    L  +    I  + +  ++ I  +   D 
Sbjct: 7396 TVKAGTKIELPATVTGKPEPKIT--WTKADMILKQDKRITIENVPKKSTVTIVDSKRSDT 7453

Query: 565  GTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLI 623
            GTY    ++  G  +    + V   P  P      ++ V   +  LTW  P D G S + 
Sbjct: 7454 GTYIIEAVNVCGRATAVVEVNVLDKPGPPA--AFDITDVTNESCLLTWNPPRDDGGSKIT 7511

Query: 624  RYILEMSENNAP-WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTER 682
             Y++E    ++  W  L ++V  K T+     L+P + Y FR+ A N  G G+  + +  
Sbjct: 7512 NYVVERRATDSEVWHKLSSTV--KDTNFKATKLIPNKEYIFRVAAENMYGVGEPVQASPI 7569

Query: 683  VSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFK 742
             +  +  P  PP  +  S  T  ++ + W  P +   + I  GY +           +  
Sbjct: 7570 TAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPIT-GYWVERLDPDTDKWVRCN 7628

Query: 743  NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGV--PTVPPGNVHA 800
             +   D     ++ L     Y   V A N AG G  S       ++    P  PPG    
Sbjct: 7629 KMPVKDTT-YRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPWPPGKPTV 7687

Query: 801  EATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSG 860
            +    T++R  W  P       I + Y +   +   +E V +    P  Q       + G
Sbjct: 7688 KDVGKTSVRLNWTKPEHDGGAKI-ESYVIEMLKTGTDEWVRVAEGVPTTQH-----LLPG 7741

Query: 861  LKKFTEYFTSVLCFTTPGDGPRSTPQ---LVRTHEDVPGPVGHLSFSEILDTSLKVSWQE 917
            L +  EY   V      G+   S P    L R     P P   L    I   +  + W  
Sbjct: 7742 LMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVINITKNTADLKWTV 7801

Query: 918  PGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQ 976
            P +  G  +T Y +   +  R   +        T +  VT LT  + Y   VAA  + GQ
Sbjct: 7802 PEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDT-KCTVTPLTEGSLYVFRVAAENAIGQ 7860

Query: 977  GQVSA--STISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVG 1033
               +    ++ +      PGPP  L + ++  R V L++ P   DG   I R+++E +  
Sbjct: 7861 SDYTEIEDSVLAKDTFTTPGPPYALAVVDVTKRHVDLKWEPPKNDGGRPIQRYVIEKKER 7920

Query: 1034 VVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ 1093
            +   G  W+   + +  PD  +  V D+   T   F++R  N  G   PS+P+ +I +++
Sbjct: 7921 L---GTRWVKAGKTAG-PDC-NFRVTDVIEGTEVQFQVRAENEAGVGHPSEPT-EILSIE 7974

Query: 1094 AP--PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKI--------KYSRSDG 1143
             P  P   P ++ +  A    + + W P    E NG    +GY +        K+ R + 
Sbjct: 7975 DPTSPPSPPLDLHVTDAGRKHIAIAWKP---PEKNGGSPIIGYHVEMCPVGTEKWMRVNS 8031

Query: 1144 HG-KTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG---SGPWSQTVVGRTRESVP 1199
               K L   V++ V  D          EY ++V+A NAIG       S+ VV +  +  P
Sbjct: 8032 RPIKDLKFKVEEGVVPD---------KEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKP 8082

Query: 1200 SSG--PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNS 1257
            +      ++  +     S+ V +  VP       V  +K   + K SD      L   N 
Sbjct: 8083 TIDLETHDIIVIEGEKLSIPVPFRAVPVPT----VSWHKDGKEVKASDR-----LTMKND 8133

Query: 1258 SRSAQLTGLGKYVLYEVQVLAFT---RIGDGSPSHPPILERTLDDVPGPPMGILFPEVRT 1314
              SA L  + K V  +  +   T   ++G  + S    +   +  +PGP   I   ++  
Sbjct: 8134 HISAHLE-VPKSVRADAGIYTITLENKLGSATAS----INVKVIGLPGPCKDIKASDITK 8188

Query: 1315 TSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFR 1374
            +S +L W+PP    G  + + +  R          V +   +   +T   L P   Y FR
Sbjct: 8189 SSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPV-MSGENKLSWTVKDLIPNGEYFFR 8247

Query: 1375 ITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPM-VQQEDVRARSVLLSWEPGS-DGLSPV 1432
            + A  + G GE  E L      +D  QPP  P+ V+  +  A ++ ++W+P   DG S +
Sbjct: 8248 VKAVNKVGGGEYIE-LKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKI 8306

Query: 1433 RYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESE 1492
              Y I+       RW   +  +     ++    L+    Y+FRV+A N  G SE S  + 
Sbjct: 8307 MGYIIEKIAKGEERWKRCNEHLVP-ILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATP 8365

Query: 1493 SLTTLQAAPDEAPTIL-------------------SVTPHTTTSVLIRWQP------PAE 1527
               T    P +AP ++                   S +P+ T    I W        P E
Sbjct: 8366 P--TKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSPYPT----ITWIKDENVIVPEE 8419

Query: 1528 DKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELD 1587
             K     L   +R R+   +    F L            LT   S+ N  +        D
Sbjct: 8420 IKKRAAPL---VRRRKGEVQEEEPFVL-----------PLTQRLSIDNSKKGESQLRVRD 8465

Query: 1588 NLNK-HRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEP 1646
            +L   H  Y I++   + + + P +      V        P N V      T +   WEP
Sbjct: 8466 SLRPDHGLYMIKVENDHGIAKAPCT------VSVLDTPGPPINFVFEDIRKTSVLCKWEP 8519

Query: 1647 PPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAA 1706
            P LD    +I  Y +   +  + +    V T  L      +  L     Y+  V A N  
Sbjct: 8520 P-LDDGGSEIINYTLEKKDKTKPDSEWIVVTSTLRHCKYSVTKLIEGKEYLFRVRAENRF 8578

Query: 1707 GDGPR--STPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPC 1764
            G GP   S P   +     P AP      ++T+ S+ V W  P+     + GY L     
Sbjct: 8579 GPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTSNSMLVKWNEPKDNGSPILGYWLEKREV 8638

Query: 1765 SPV--DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT----YGPEIEANVTT 1818
            +      V+K +   +K N      V  L EG+TY FR+ A+       + P  +     
Sbjct: 8639 NSTHWSRVNKSLLNALKAN------VDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAH 8692

Query: 1819 GPGEGAPGPPGVPIIVRYSSAIAIHWSS-GDPGKGPITRYVIEARPSDEGLWDILIKDIP 1877
             P    PGPP   +    S+ I + W      G G I  Y ++ +      W    + + 
Sbjct: 8693 DP-ISPPGPPIPRVTDTSSTTIELEWEPPAFNGGGEIVGYFVDKQLVGTNEWSRCTEKMI 8751

Query: 1878 KEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKANP 1925
            K V  YT     ++ G  Y  RV AVN  G G P        A+   P
Sbjct: 8752 K-VRQYTVKE--IREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEP 8796



 Score =  207 bits (527), Expect = 9e-53
 Identities = 337/1448 (23%), Positives = 550/1448 (37%), Gaps = 155/1448 (10%)

Query: 523   PRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQTWSGDIGTYTCRVISAGGNDSRS 581
             P+ T+   W KDG TL   +   +   +   SL I +    D+GTY   V ++ G+ +  
Sbjct: 19117 PQATVN--WRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVP 19174

Query: 582   AHLRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP-WTVL 639
               + V   P  P  P+  +  V   +I ++W  P +DG   +  YI+E  E  +  W ++
Sbjct: 19175 ITIIVLDRP-GPPGPIR-IDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIV 19232

Query: 640   LASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIA 699
               +V    TS+ +  L     YQFR+CA N  GK  +S+ +  V+     P  PP     
Sbjct: 19233 SQAV--ARTSIKIVRLTTGSEYQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKV 19290

Query: 700   SGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLII 759
                T  ++++ WQ P     + ++ GY + Y      +  +   I  AD   + +  L  
Sbjct: 19291 VHATKSTMLVTWQVPVNDGGSRVI-GYHLEYKERSSILWSKANKILIADTQ-MKVSGLDE 19348

Query: 760   WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQF 819
                YE  V A N AG+G   SK  E      P  PPG          ++   W+ P    
Sbjct: 19349 GLMYEYRVYAENIAGIGK-CSKSCEPVPARDPCDPPGQPEVTNITRKSVSLKWSKPH--- 19404

Query: 820   INGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEY----FTSVLCF 874
                 + G K+  +  E+ E       + N+ +     F V+ L +   Y    F      
Sbjct: 19405 ---YDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAAD 19461

Query: 875   TTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTS----LKVSWQEPGEKNGILTGYRI 930
             +       + P +V+   + P  +  + F +++       LK++    G    +++  + 
Sbjct: 19462 SVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKD 19521

Query: 931   SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPP 990
               E   R  T +     +  L  +         Y + +  +       V+   +      
Sbjct: 19522 GIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDK---- 19577

Query: 991   ELPGPPTN-LGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLS 1048
               PGPP   L I+ +     +L + RP  DG   I  ++VE +         W +     
Sbjct: 19578 --PGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIVEKRET---SHLAWTICE--- 19629

Query: 1049  NEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPP--SQPSRKIQTLQAPPDMAPANVSLR 1106
              E    S +V  L     Y FR+  VN  G   P  S   + +     P    P ++ + 
Sbjct: 19630 GELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSP--PTSLEIT 19687

Query: 1107  TASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHV-VQDRVERDYTIED- 1164
             + ++ S+ L W      E +G  E  GY I+    +    +L  V V  +   D  ++  
Sbjct: 19688 SVTKESMTLCWS---RPESDGGSEISGYIIERREKN----SLRWVRVNKKPVYDLRVKST 19740

Query: 1165  -LEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESV----PSSGPTNVSALATTSSSMLV 1218
              L E  EY  +V A NA G S P   + + R  + V    P S P  V +  TT   + +
Sbjct: 19741 GLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTT---ITI 19797

Query: 1219  RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLT--GLGKYVLYEVQV 1276
              W + P  D    + GY V YK+ D DT    W     S R  + T  GL     Y  +V
Sbjct: 19798 AWVK-PLFDGGAPITGYTVEYKKSD-DTD---WKTSIQSLRGTEYTISGLTTGAEYVFRV 19852

Query: 1277  LAFTRIGDGSPSH---PPILERTLDDVPGPPMGILFPEVRTTSV---RLIWQPPAAPNGI 1330
              +  ++G   PS    P I +   ++    P+  +  E+R T +      +       G 
Sbjct: 19853 KSVNKVGASDPSDSSDPQIAKEREEE----PLFDIDSEMRKTLIVKAGASFTMTVPFRGR 19908

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL 1390
              +   +  + +T     A V+    S    T           + +T Q       +A +L
Sbjct: 19909 PVPNVLWSKPDTDLRTRAYVDT-TDSRTSLTIENANRNDSGKYTLTIQNVL----SAASL 19963

Query: 1391  VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWAL 1449
              +  +  D P PP+   VQ  DV   S +LSW+ P +DG +PV+ Y I+ RE     W  
Sbjct: 19964 TLVVKVLDTPGPPTNITVQ--DVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWV- 20020

Query: 1450  HSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILS 1509
              S + + N  S+ V  L+    Y FRV   N+ G    +E  E +   +      P  L 
Sbjct: 20021 -SVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKP--SPPEKLG 20077

Query: 1510  VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 1569
             VT  +  SV + W  P  D       G RI +          + +  +      W +   
Sbjct: 20078 VTSISKDSVSLTWLKPEHDG------GSRIVH----------YVVEALEKGQKNWVKCAV 20121

Query: 1570  MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV------P 1623
               S         T + +  L ++  Y  R+   N  G    S P+E+ +   +      P
Sbjct: 20122 AKS---------THHVVSGLRENSEYFFRVFAENQAG---LSDPRELLLPVLIKEQLEPP 20169

Query: 1624  TAAPRN-----VVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTL 1678
                 +N     V V   +  ++D+     PL        G  +          T R  T 
Sbjct: 20170 EIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPL--------KATMRFNTE 20221

Query: 1679  FLAEN-SVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTT 1737
               AEN ++ LK      A    + A N++G            +   P+ P  V  S++T 
Sbjct: 20222 ITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGP--VVISDITE 20279

Query: 1738  TSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVT 1796
              SV + WE P++  G  +  Y L+    S         TV     +   +KV  L  G  
Sbjct: 20280 ESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATV-----ARTMMKVMKLTTGEE 20334

Query: 1797  YRFRIRAKT-FTYGPEIE-ANVTTGPGEGAPGPPGVPIIVRYS-SAIAIHWSSG-DPGKG 1852
             Y+FRI+A+  F     I+ A VT       PGPP  P +   +  +I + W      G  
Sbjct: 20335 YQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGS 20394

Query: 1853  PITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPS 1912
              +  Y +E +  +  LW    K +   + +  F +  +  G+ Y+FRV A N  G G PS
Sbjct: 20395 AVVGYHLEMKDRNSILWQKANKLV---IRTTHFKVTTISAGLIYEFRVYAENAAGVGKPS 20451

Query: 1913  SPSQSVPA 1920
              PS+ V A
Sbjct: 20452 HPSEPVLA 20459



 Score =  207 bits (526), Expect = 1e-52
 Identities = 333/1443 (23%), Positives = 538/1443 (37%), Gaps = 164/1443 (11%)

Query: 531   WEKDGATLGTESHPRIRLDRNGS-LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
             W  DG+ + T+ H  +  D   S L I      D G Y   V +A G+ + + HL V  +
Sbjct: 11239 WTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDV 11298

Query: 590   PHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLASVDPKAT 648
             P  P  P+  L       + ++W  P D G SP+I YI+E  +       +++S   K T
Sbjct: 11299 PGPPTGPINILDVTPEH-MTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSK-T 11356

Query: 649   SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIM 708
              + +  L     Y FR+ A N +G G     T  V+  +  P +PP   + +  T  +  
Sbjct: 11357 KLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAAT 11416

Query: 709   IQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768
             + W  P     + I   Y+ R  + G  V      I D       +  L     YE  V 
Sbjct: 11417 VSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADL---KFRVTGLYEGNTYEFRVF 11473

Query: 769   AYNSAGLG--VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQG 826
             A N AGL     SS   +      P  PP N   +  +  T    W  P        + G
Sbjct: 11474 AENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLS------DGG 11527

Query: 827   YKLIAWEPEQEEEVTMVTARPNFQDSIH--VGFVSGLKKFTEYFTSVLCFTTPGDG-PRS 883
               ++ +  E ++  T    R N  + I      V GL +  EY   +      G+G PR 
Sbjct: 11528 SPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRE 11587

Query: 884   TPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYR------ISWEEYNR 937
               + V     +   + H    E+  T   V     G+   IL   +      I+W +  +
Sbjct: 11588 LAESV-----IAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGK 11642

Query: 938   TNTR-----VTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992
                R     +   LP V L+ +         Y I     +   QG    + +      + 
Sbjct: 11643 VLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVL------DR 11696

Query: 993   PGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
             PGP  NL ++N+   + T+ +  P  +G + I+ ++VE +       + W ++   +++ 
Sbjct: 11697 PGPCQNLKVTNVTKENCTISWENPLDNGGSEITNFIVEYR---KPNQKGWSIV---ASDV 11750

Query: 1052  DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQ---PSRKIQTLQAPPDMAPANVSLRTA 1108
               R ++  +L     Y FR+   N VG  P  +   P   I  +  P +  P N+ +   
Sbjct: 11751 TKRLIKA-NLLANNEYYFRVCAENKVGVGPTIETKTPILAINPIDRPGE--PENLHIADK 11807

Query: 1109  SETSLWLRWMPLPEMEYNGNPESVGYKI--KYSRSDGHGKTLSHVVQDRVERDYTIEDLE 1166
              +T ++L+W      +Y+G   ++ Y +  +   SD   +     ++   E  Y ++   
Sbjct: 11808 GKTFVYLKWR---RPDYDGGSPNLSYHVERRLKGSDDWERVHKGSIK---ETHYMVDRCV 11861

Query: 1167  EWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPS-------SGPTNVSALATTSSSMLVR 1219
             E   Y  +VQ  N  G   W +T     +E +         SG   V A  T      VR
Sbjct: 11862 ENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVR 11921

Query: 1220  WSEVPEA----DRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQ 1275
                 PE     D++   L      K        +F L +   S        GKYV     
Sbjct: 11922 GKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDG------GKYV----- 11970

Query: 1276  VLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQ 1335
             V A    G    S        + D PGP   +   +V +    + W PP    G  +   
Sbjct: 11971 VTATNTAG----SFVAYATVNVLDKPGPVRNLKIVDVSSDRCTVCWDPPEDDGGCEIQNY 12026

Query: 1336  ITHRLNTTTA--NTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VV 1392
             I  +  T     +T +  VL P     T T L   + Y+FR+ A+ + G G   E+  V+
Sbjct: 12027 ILEKCETKRMVWSTYSATVLTPGT---TVTRLIEGNEYIFRVRAENKIGTGPPTESKPVI 12083

Query: 1393  TTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSGRWA-LH 1450
                K D+P  P  P V +  V    + + W P   DG   +  Y ++ +E  S RW  ++
Sbjct: 12084 AKTKYDKPGRPDPPEVTK--VSKEEMTVVWNPPEYDGGKSITGYFLEKKEKHSTRWVPVN 12141

Query: 1451  SASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQ-AAPDEAPTILS 1509
              +++        V  L P   Y+FRVKA N+IG  E S  S  +       P   PT   
Sbjct: 12142 KSAIPERRMK--VQNLLPDHEYQFRVKAENEIGIGEPSLPSRPVVAKDPIEPPGPPTNFR 12199

Query: 1510  VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 1569
             V   T  S+ + W  P  D     ++G+ +  R  + +           +P   W    +
Sbjct: 12200 VVDTTKHSITLGWGKPVYDG-GAPIIGYVVEMRPKIADA----------SPDEGWKRCNA 12248

Query: 1570  MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG------PSSPPQEVFVGEAVP 1623
                +         ++ + +L++++ YE R+   N VG G       +  P+E+     + 
Sbjct: 12249 AAQLVR------KEFTVTSLDENQEYEFRVCAQNQVGIGRPAELKEAIKPKEILEPPEID 12302

Query: 1624  TAAP--RNVVVHGATATQL--DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTL- 1678
               A   + V+V      +L   V   P P       +   K+      R    + V T+ 
Sbjct: 12303 LDASMRKLVIVRAGCPIRLFAIVRGRPAP------KVTWRKVGIDNVVRKGQVDLVDTMA 12356

Query: 1679  FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
             FL   +    +   Y+  +V+ A   A     R   T        P   S +K S++T T
Sbjct: 12357 FLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRVLDT--------PGPVSDLKVSDVTKT 12408

Query: 1739  SVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYR 1798
             S +VSW  P+   G    + +V E           VT +VK  S     V +L  G  Y 
Sbjct: 12409 SCHVSWAPPENDGGSQVTHYIV-EKREADRKTWSTVTPEVKKTS---FHVTNLVPGNEYY 12464

Query: 1799  FRIRAKTFTYGPEIEANV-----TTGPGEGAPGPPGVPIIVRYSSAIAIHW-----SSGD 1848
             FR+ A    YGP +  +V      + P      P  + +     ++  + W       G 
Sbjct: 12465 FRVTAVN-EYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWLPPLRDGGA 12523

Query: 1849  PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGF 1908
                G IT Y  E +P+D      ++KD+   V+        LK G  Y FRV A N  G 
Sbjct: 12524 KIDGYITSYREEEQPADRWTEYSVVKDLSLVVTG-------LKEGKKYKFRVAARNAVGV 12576

Query: 1909  GTP 1911
               P
Sbjct: 12577 SLP 12579



 Score =  204 bits (520), Expect = 6e-52
 Identities = 375/1638 (22%), Positives = 639/1638 (39%), Gaps = 191/1638 (11%)

Query: 362   DGGLQISGLVPDDTGMFQCFARNAAG---EVQTSTYLAVTS----IAPNITRGP--LDST 412
             D   +++GLV D    F+  ARNAAG   E   ST  A+T+      P I+  P   D+ 
Sbjct: 16190 DTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTG-AITARDEVDPPRISMDPKYKDTI 16248

Query: 413   VID-GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
             V+  G S  +  +  G P P I W KG++ L S + +L   +   + SL +      D+G
Sbjct: 16249 VVHAGESFKVDADIYGKPIPTIQWIKGDQEL-SNTARLEIKSTDFATSLSVKDAVRVDSG 16307

Query: 472   TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQA---------------SMV 516
              Y   A N  G    + ++ V  R     PP+   VI G  A               S +
Sbjct: 16308 NYILKAKNVAGERSVTVNVKVLDR---PGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDI 16364

Query: 517   CGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG- 575
                  + R T R +W    A + T            S  +++   G+   YT R+++   
Sbjct: 16365 INYIVERRETSRLVWTVVDANVQTL-----------SCKVTKLLEGN--EYTFRIMAVNK 16411

Query: 576   ---GNDSRSAHLRVRQ---LPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILE 628
                G    S  +  +    +P AP+ P  T  TV + ++ + W +P  DG S ++ Y+LE
Sbjct: 16412 YGVGEPLESEPVVAKNPFVVPDAPKAPEVT--TVTKDSMIVVWERPASDGGSEILGYVLE 16469

Query: 629   MSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT--ERVSL 685
               +     WT     +  +   + V GL+    Y+FR+ A N  G  + S  +  ++   
Sbjct: 16470 KRDKEGIRWTRCHKRLIGE-LRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACD 16528

Query: 686   PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNI 744
             P   P  PP N      T  S+ + W  P   +  G  ++GYI+  C   +         
Sbjct: 16529 PIYKP-GPPNNPKVIDITRSSVFLSWSKP--IYDGGCEIQGYIVEKCDVSVGEWTMCTPP 16585

Query: 745   TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATN 804
             T  +  N+ +E L+    Y   + A N AG+G ++       ++     P  ++  E   
Sbjct: 16586 TGINKTNIEVEKLLEKHEYNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRK 16645

Query: 805   STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEE--EVTMVTARPNFQDSIHVGFVSGLK 862
                IR         F+    +    + W     E  +  ++    +F   +       L 
Sbjct: 16646 IINIRA--GGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLV-------LD 16696

Query: 863   KFTEYFTSVLCFTTP-GDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEK 921
                 Y +     T     G +S    VR   D P P  +L  +EI   S+ ++W+ P   
Sbjct: 16697 NVNRYDSGKYTLTLENSSGTKSAFVTVRV-LDTPSPPVNLKVTEITKDSVSITWEPPLLD 16755

Query: 922   NGI-LTGYRISWEEYNRTN--TRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ 978
              G  +  Y +   E  R +    VT+   N    +++  L    +Y   V A    G G 
Sbjct: 16756 GGSKIKNYIVEKREATRKSYAAVVTNCHKN---SWKIDQLQEGCSYYFRVTAENEYGIG- 16811

Query: 979   VSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGE 1037
             + A T       E+P PP  + + ++   SV+L + +P +DG + I +++VE Q      
Sbjct: 16812 LPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQ---AKH 16868

Query: 1038  GEEWLLIHQLSNEPDARSME--VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKI--QTLQ 1093
              E+W      S     +S++  + +L     Y FR+  VN  G S P   +  I  + L 
Sbjct: 16869 SEKW------SECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLV 16922

Query: 1094  APPDMAPA--NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHV 1151
               PD+ PA  + S++   +  +        E+  +G P+     I +++     K  + +
Sbjct: 16923 IEPDVKPAFSSYSVQVGQDLKI--------EVPISGRPKPT---ITWTKDGLPLKQTTRI 16971

Query: 1152  -VQDRVE-RDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSAL 1209
              V D ++    +I++  +    +  +   N +G    S  +V   +   P  GP     +
Sbjct: 16972 NVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPD-PPKGPVKFDDV 17030

Query: 1210  ATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW-LVEGNSSRSA-QLTGLG 1267
               ++ S+ + W+  P     G  +   ++ K    DT    W +V    +R+  ++T L 
Sbjct: 17031 --SAESITLSWN--PPLYTGGCQITNYIVQKR---DTTTTVWDVVSATVARTTLKVTKLK 17083

Query: 1268  KYVLYEVQVLAFTRIGDG-SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAA 1326
                 Y+ ++ A  R G   +    PI+ +     PGPP       +   S+ + W  P  
Sbjct: 17084 TGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVN 17143

Query: 1327  PNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGE 1385
               G  ++ Y +  +   +   T   + +     Q+ A  L+    Y FR+ A+   G G+
Sbjct: 17144 NGGSPVIGYHLERKERNSILWTKVNKTIIHDT-QFKAQNLEEGIEYEFRVYAENIVGVGK 17202

Query: 1386  AAE--ALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTREL 1442
             A++     V  +  D P  P   MV++ +     + L W +P  DG S +  Y ++ R+L
Sbjct: 17203 ASKNSECYVARDPCDPPGTPEPIMVKRNE-----ITLQWTKPVYDGGSMITGYIVEKRDL 17257

Query: 1443  PSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPD 1502
             P GRW + ++  +   + F V  L     Y+FRV A N  G    S+ S+S   + A  +
Sbjct: 17258 PDGRW-MKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAG--AISKPSDSTGPITAKDE 17314

Query: 1503  EAPTILSVTPHTTTSVLIRWQPP--AEDKINGILLGFRIRYRELLYEGLRG-FTLRGINN 1559
                  +S+ P    ++++        E  ++G  L           E LRG   +     
Sbjct: 17315 VELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP--------TIEWLRGDKEIEESAR 17366

Query: 1560  PGATWAELTSMYSMRNLSRPSLTQYEL--DNLNKHRRYEIRMSVYNAVG--EGPSSPPQE 1615
                   +  ++  +++  R    QY L   N+   + + + + V +  G  EGP      
Sbjct: 17367 CEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGP------ 17420

Query: 1616  VFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERV 1675
                           V V G T+ +  +TW  PPL     DI  Y +   E  R  L   V
Sbjct: 17421 --------------VQVTGVTSEKCSLTWS-PPLQDGGSDISHYVVEKRETSR--LAWTV 17463

Query: 1676  KTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFS 1733
                 +  NS+K+  L     Y+  + A N  G G    S P   +     P  P S++ +
Sbjct: 17464 VASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVT 17523

Query: 1734  ELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLA 1792
              +   S+ V W  P    G  + GY +     S +    + +  + +  + L L+V  L 
Sbjct: 17524 NIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGI----RWIKCNKRRITDLRLRVTGLT 17579

Query: 1793  EGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGA--PGPP-GVPIIVRYSSAIAIHWSSGD 1848
             E   Y FR+ A+     G    A V     +    PGPP    I+    ++I + W  G 
Sbjct: 17580 EDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAW--GK 17637

Query: 1849  P---GKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVND 1905
             P   G   I  YV+E   +DE  W I+       V+ +  S   L     Y  RV A+N 
Sbjct: 17638 PIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISK--LTEHQEYKIRVCALNK 17695

Query: 1906  YGFGTPSS-PSQSVPAQK 1922
              G G  +S P    P  K
Sbjct: 17696 VGLGEATSVPGTVKPEDK 17713



 Score =  202 bits (515), Expect = 2e-51
 Identities = 431/1978 (21%), Positives = 725/1978 (36%), Gaps = 286/1978 (14%)

Query: 73    EYRYMITSLDRTHAGFYRCIVRNRMGAL----------LQRQTEVQ--VAYMGSFEEGEK 120
             E +Y +T L       +R I RN +G +          + R   V   V +   + +G  
Sbjct: 21605 ECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDG-- 21662

Query: 121   HQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAIT--LENTLVILSTVAPDA 178
                +  GE+  I+A  +   P P+VTWF+DG +I     + IT  L +T + +     D 
Sbjct: 21663 -LIIKSGESLRIKA-LVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDH 21720

Query: 179   GRYYVQAVNDKNGDNKTSQPITL--TVENVGGPA-------------------DPIAPTI 217
                Y     + +G  K    + +  T   V GP                    D  AP  
Sbjct: 21721 RGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPIT 21780

Query: 218   --IIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPT 275
               II  + TS +A    +  +C A +   IKL      +G      +S  N+   +  P 
Sbjct: 21781 HYIIEKRETSRLAWAL-IEDKCEAQSYTAIKLI-----NGNEYQFRVSAVNK-FGVGRPL 21833

Query: 276   GSDAGYYECEAVLRSSS---VPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQA 332
              SD    + +  +  +     PS + G  +++         PE    +E+++ +    + 
Sbjct: 21834 DSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWA-----RPESDGGSEIQQYILERREK 21888

Query: 333   KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTS 392
             K     S  W K  +   + + TRF+        ++GL   +   F   A NAAG    S
Sbjct: 21889 K-----STRWVKVISKRPISE-TRFK--------VTGLTEGNEYEFHVMAENAAGVGPAS 21934

Query: 393   ------------------TYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAIT 434
                               T + VT  +           V DG   ++             
Sbjct: 21935 GISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD 21994

Query: 435   WQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGV-DEASADLVVW 493
             W K   + A   V+  R+T        ++     +   +   A N  G  D       + 
Sbjct: 21995 WHK---VNAEACVKT-RYT--------VTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIK 22042

Query: 494   ARTRITKPPQD------QSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIR 547
             A  R+T P  D      Q+ +    AS+   + +  R T   +W K  + L   +     
Sbjct: 22043 AVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTT 22102

Query: 548   LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRA 607
              D   +L +      D G YT  V +  G+ S +  ++V   P  P  P+ T   V R +
Sbjct: 22103 -DSFSTLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTP-GPPGPI-TFKDVTRGS 22159

Query: 608   INLTWTKPF-DGNSPLIRYILEMSE-NNAPWTVLLASVDPKATS--VTVKGLVPARSYQF 663
               L W  P  DG + +  Y++E  E +   W V    +  K T     V  L     Y F
Sbjct: 22160 ATLMWDAPLLDGGARIHHYVVEKREASRRSWQV----ISEKCTRQIFKVNDLAEGVPYYF 22215

Query: 664   RLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI- 722
             R+ AVN+ G G+  +  E +   E+P  APP+ +     +  S ++ W  P   H  G  
Sbjct: 22216 RVSAVNEYGVGEPYEMPEPIVATEQP--APPRRLDVVDTSKSSAVLAWLKP--DHDGGSR 22271

Query: 723   LKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLG----VY 778
             + GY++     G     +  +          +E L+  T YE  V A N AG       +
Sbjct: 22272 ITGYLLEMRQKGSDFWVEAGHTKQL---TFTVERLVEKTEYEFRVKAKNDAGYSEPREAF 22328

Query: 779   SSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQG-------YKLIA 831
             SS + +      P + P    A+ T  T    T  A SP  I+    G       +KL  
Sbjct: 22329 SSVIIK-----EPQIEPT---ADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEE 22380

Query: 832   WEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTH 891
                ++ + V++ T +     ++         +   YF ++    T G    S   +V   
Sbjct: 22381 MRLKETDRVSITTTKDRTTLTVKDSMRGDSGR---YFLTLE--NTAGVKTFSVTVVVIGR 22435

Query: 892   EDVPGPV-GHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNV 949
                PGPV G +  S +   S  +SW EP +  G  +T Y +   E   T  ++ +     
Sbjct: 22436 ---PGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKR 22492

Query: 950   TLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPTNLGISNIGPRS 1008
             T + +VT LT    Y+  V++    G  + + ++ I +  P   P  PT   + ++   +
Sbjct: 22493 T-QIKVTHLTKYMEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANA 22551

Query: 1009  VTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067
             +++++  P +DG + I  + VE +     E    L + +        + +V  L     Y
Sbjct: 22552 MSIRWEEPYHDGGSKIIGYWVEKK-----ERNTILWVKENKVPCLECNYKVTGLVEGLEY 22606

Query: 1068  SFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNG 1127
              FR   +N  G S  S+ SR I   Q P D AP    +   + +++ L W       Y+G
Sbjct: 22607 QFRTYALNAAGVSKASEASRPIMA-QNPVD-APGRPEVTDVTRSTVSLIWSA---PAYDG 22661

Query: 1128  NPESVGYKI--KYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGP 1185
               + VGY I  K     G G+ L        +  +T+  L E   Y  +V A NA G   
Sbjct: 22662 GSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKNAAG--- 22718

Query: 1186  WSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSD 1245
                 V+ +  ES       +  A         +    V     + LVL   V  K     
Sbjct: 22719 ----VISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKP---- 22770

Query: 1246  TQPRFWLVEGNSSR------SAQLTGL--------------GKYVLYEVQVLAFTRIGDG 1285
              +P+    +G+         S Q TG               GKY L          +   
Sbjct: 22771 -EPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVS-- 22827

Query: 1286  SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTA 1345
                   ++ + LD  PGP   +    V      L W  P    G  + + I  R  T+  
Sbjct: 22828 ------VMVKVLDS-PGPCGKLTVSRVTQEKCTLAWSLPQEDGGAEITHYIVERRETSRL 22880

Query: 1346  NTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VVTTEKRDRPQPPS 1404
             N   VE   P+   Y  T L   + Y+FR+ A  + G G   E+  +V       P PP 
Sbjct: 22881 NWVIVEGECPTL-SYVVTRLIKNNEYIFRVRAVNKYGPGVPVESEPIVARNSFTIPSPPG 22939

Query: 1405  RPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIV 1463
              P  ++       +++ W +P SDG + +  Y +  RE  S RW   +       +   V
Sbjct: 22940 IP--EEVGTGKEHIIIQWTKPESDGGNEISNYLVDKREKKSLRWTRVNKDYVVYDTRLKV 22997

Query: 1464  DRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA----PDEAPTILSVTPHTTTSVL 1519
               L     Y+FRV A N  G+SE SE S  ++  + +    P  AP ++  T H   S+ 
Sbjct: 22998 TSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPSYTPGPPSAPRVVDTTKH---SIS 23054

Query: 1520  IRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRP 1579
             + W  P  D    I+                G+ L         W  + +  ++RN    
Sbjct: 23055 LAWTKPMYDGGTDIV----------------GYVLEMQEKDTDQWYRVHTNATIRN---- 23094

Query: 1580  SLTQYELDNLNKHRRYEIRMSVYNAVGEGPSS-------PPQEVFVGE-AVPTAAPRNVV 1631
               T++ + +L   ++Y  R++  N  G    S       P + + + +  +     + V 
Sbjct: 23095 --TEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVT 23152

Query: 1632  VHGATATQL--DVTWEPPPL---DSQNGDIQGYKIY-FWEAQRGNLTERVKTLFLAENSV 1685
             +    + +L   V+  PPP+     Q  D+    I    E+    + ++V      + ++
Sbjct: 23153 IRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTI 23212

Query: 1686  KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWE 1745
             + +N +G  +  V V  ++  G  P                  SVK  E++  SV ++WE
Sbjct: 23213 EAENQSGKKSATVLVKVYDTPGPCP------------------SVKVKEVSRDSVTITWE 23254

Query: 1746  APQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKT 1805
              P    G      +V +  +    +    TV  K +  L+ ++  L EG  Y FR+  + 
Sbjct: 23255 IPTIDGGAPVNNYIVEKREA---AMRAFKTVTTKCSKTLY-RISGLVEGTMYYFRVLPEN 23310

Query: 1806  -FTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSG-DPGKGPITRYVIEARP 1863
              +  G   E +      E    P  + ++    S + + W      G   +T YV+EA  
Sbjct: 23311 IYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACK 23370

Query: 1864  SDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQ 1921
             +    W   +K +  + +    ++  L  G  Y FR+ A N+ G   P     +V  Q
Sbjct: 23371 AGTERW---MKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQ 23425



 Score =  201 bits (512), Expect = 5e-51
 Identities = 369/1646 (22%), Positives = 603/1646 (36%), Gaps = 237/1646 (14%)

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP---LDSTVIDGMS----- 418
             ++ LV      F+  A+N AG +   +    T I  +    P   LD T+ DG++     
Sbjct: 14030 VTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGD 14089

Query: 419   --VVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
               V+ A    G P P  +W K  + +    +     TP  S  L I      DAG YT  
Sbjct: 14090 TIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSS-MLTIKYATRKDAGEYTIT 14148

Query: 477   ATNSRGVDEASADLVVW------ARTRITKPPQDQSVIKGTQ-----ASMVCGVTHDPRV 525
             ATN  G       + V           I+    +++ +  T       S +     + R 
Sbjct: 14149 ATNPFGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRE 14208

Query: 526   TIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG----GNDSRS 581
             T R +W      + +  H   +L +                Y  RV +      G   +S
Sbjct: 14209 TSRLLWTVVSEDIQSCRHVATKLIQGNE-------------YIFRVSAVNHYGKGEPVQS 14255

Query: 582   AHLRVRQL---PHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWT 637
               +++      P  PE P   +S V +    ++W +P D G S +  Y +E  E  +   
Sbjct: 14256 EPVKMVDRFGPPGPPEKP--EVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRW 14313

Query: 638   VLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP-PTAPPQN 696
             V             V GL    +Y+FR+ A N  G G  S+ ++ V + +   P  PP N
Sbjct: 14314 VRAIKTPVSDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 14373

Query: 697   VIASGRTNQSIMIQWQPPPESHQNGILK--GYIIRYCLAGLPVGYQFKNITDADVNNLLL 754
                +  T +S  + W  P   H +G L+  GY++ +   G     +    T   +   ++
Sbjct: 14374 PHVTDTTKKSASLAWGKP---HYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVV 14430

Query: 755   EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNA 814
              DL     Y   ++A N AG+G   + + +  +      P   + AE   +  +R     
Sbjct: 14431 PDLQTKEKYNFRISAINDAGVGE-PAVIPDVEIVEREMAPDFELDAELRRTLVVR----- 14484

Query: 815   PSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCF 874
                        G  +  + P +      VT     +D+I++   + ++  TE FT ++  
Sbjct: 14485 ----------AGLSIRIFVPIKGRPAPEVTWT---KDNINLKNRANIEN-TESFTLLII- 14529

Query: 875   TTPGDGPRSTPQLVRTHE---------------DVPGPVGHLSFSEILDTSLKVSWQEPG 919
               P      T + V T E               D PGPV +L  ++I   S+ + W  P 
Sbjct: 14530 --PECNRYDTGKFVMTIENPAGKKSGFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPL 14587

Query: 920   EKNGI-LTGYRISWEEYNR----TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSK 974
                G  +T Y +   E  R    T T   H        Y+VTGL+    Y   V A    
Sbjct: 14588 IDGGSRITNYIVEKREATRKSYSTATTKCH-----KCTYKVTGLSEGCEYFFRVMAENEY 14642

Query: 975   GQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVG 1033
             G G+ + +T       E P PP +L I +I   +V+L + +P +DG + I+ +++EAQ  
Sbjct: 14643 GIGEPTETT-EPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRK 14701

Query: 1034  VVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ 1093
                  ++W  I  +          V +L     Y+F++  VN  G S             
Sbjct: 14702 ---GSDQWTHITTVKG----LECVVRNLTEGEEYTFQVMAVNSAGRS------------- 14741

Query: 1094  APPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESV-------GYKIKYSRSDGHGK 1146
             AP +  P  V  +T            LPE++  G  + +         K++         
Sbjct: 14742 APRESRPVIVKEQTM-----------LPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKP 14790

Query: 1147  TLSHVVQDRVERDYTIEDLEEW-TEYRVQVQAFNAIGSGPWSQT---VVGRTRESV---- 1198
             T++    D++ +     + E   T   + +       SGP+  T   +VG   + +    
Sbjct: 14791 TVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQV 14850

Query: 1199  -----PSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLV 1253
                  P +GP     ++  S  +   W + PE D    +  Y V  ++ DS T       
Sbjct: 14851 HDIPGPPTGPIKFDEVS--SDFVTFSW-DPPENDGGVPISNYVVEMRQTDSTTWVELATT 14907

Query: 1254  EGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEV 1312
                ++  A  T L   + Y+ +V A  R G G   +   I+      VPGPP       V
Sbjct: 14908 VIRTTYKA--TRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAV 14965

Query: 1313  RTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVY 1371
                S+ + W  P +  G  IL Y +  +           + L P    + ++GL     Y
Sbjct: 14966 TKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPG-NIFKSSGLTDGIAY 15024

Query: 1372  LFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQE-----------DVRARSVLL 1420
              FR+ A+   G              + +P  PS PM+  +           ++   +V L
Sbjct: 15025 EFRVIAENMAG--------------KSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTL 15070

Query: 1421  SW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKAT 1479
              W +P   G   +  Y ++ R+LP+GRW   + S +   + F V  L    +Y+FRV A 
Sbjct: 15071 KWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFS-NILENEFTVSGLTEDAAYEFRVIAK 15129

Query: 1480  NDIGD-SEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFR 1538
             N  G  S  SE S+++T       EAP I        T +L   +             FR
Sbjct: 15130 NAAGAISPPSEPSDAITCRDDV--EAPKIKVDVKFKDTVILKAGE------------AFR 15175

Query: 1539  IRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIR 1598
             +              + G   P   W++              +  +  + +NK       
Sbjct: 15176 LEA-----------DVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRR-D 15223

Query: 1599  MSVYNAVGEGPSSPPQEVFVGEAVPTAAPRN--VVVHGATATQLDVTWEPPPLDSQNGDI 1656
                Y      P    + +F  + +    P    + V   T+ +  ++W PP LD     I
Sbjct: 15224 SGAYTLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPP-LDDGGAKI 15282

Query: 1657  QGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTP 1714
               Y +   E  R   T     + + +  +K+  L     Y+  V A N  G G    S P
Sbjct: 15283 DHYIVQKRETSRLAWTNVASEVQVTK--LKVTKLLKGNEYIFRVMAVNKYGVGEPLESEP 15340

Query: 1715  TQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIV 1774
                      P  P + + + +T  S+ V W  P    G  E    + E         + +
Sbjct: 15341 VLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGS-EIINYIVERRDKAG--QRWI 15397

Query: 1775  TVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGA------PGPP 1828
               + K  + L  KV  L EG  Y FRI A+       I A   T P   A      PGPP
Sbjct: 15398 KCNKKTLTDLRYKVSGLTEGHEYEFRIMAEN---AAGISAPSPTSPFYKACDTVFKPGPP 15454

Query: 1829  GVPIIVRYS-SAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFS 1886
             G P ++  S S+I+I W+     G   IT Y++E    +E  W I+      + +SYT +
Sbjct: 15455 GNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLKATSYTIT 15514

Query: 1887  MDILKPGVSYDFRVIAVNDYGFGTPS 1912
                L     Y  R+ A+N  G G P+
Sbjct: 15515 G--LTENQEYKIRIYAMNSEGLGEPA 15538



 Score =  201 bits (510), Expect = 8e-51
 Identities = 370/1602 (23%), Positives = 611/1602 (38%), Gaps = 215/1602 (13%)

Query: 412   TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
             TV  G +V L     G P P ++W+K   +L      +         +L +   +  D+G
Sbjct: 13001 TVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAE-GIKMAMQRNLCTLELFSVNRKDSG 13059

Query: 472   TYTCLATNSRGVDEASADLVVW------ARTRITKPPQDQSVIKGTQ-----ASMVCGVT 520
              YT  A NS G   A+  L V       A  +I K   D++++          S +    
Sbjct: 13060 DYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGSEITNYI 13119

Query: 521   HDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSR 580
              D R T R  W +  AT+   S    +L                    C     G  D  
Sbjct: 13120 VDKRETSRPNWAQVSATVPITSCSVEKLIEGHEYQFR----------ICAENKYGVGDPV 13169

Query: 581   SAHLRVRQLPHAP----EHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAP 635
                  + + P+ P    + PV  +S + +  + ++W  P D G SP+  Y+LE  E  A 
Sbjct: 13170 FTEPAIAKNPYDPPGRCDPPV--ISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAV 13227

Query: 636   -WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEP--PTA 692
              WT +      + T +   GL     Y+FR+ A+N  G G+ S D  + +   +P  P  
Sbjct: 13228 NWTKVNRKPIIERT-LKATGLQEGTEYEFRVTAINKAGPGKPS-DASKAAYARDPQYPPG 13285

Query: 693   PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIR--------YCLAGLPVGYQFKNI 744
             PP        T  S+ + W  P     + I+ GY++         +    LP   Q    
Sbjct: 13286 PPAFPKVYDTTRSSVSLSWGKPAYDGGSPII-GYLVEVKRADSDNWVRCNLPQNLQK--- 13341

Query: 745   TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATN 804
             T  +V  L+ ED    T Y+  V A N  G    S    +   + +   P G + A+   
Sbjct: 13342 TRFEVTGLM-ED----TQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADLRK 13396

Query: 805   STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVT-ARPNFQDSIHVGFVSGLKK 863
             +  +R                G  +  + P +      +T ++PN      +G      K
Sbjct: 13397 TLILR---------------AGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDI---K 13438

Query: 864   FTEYFTSVLC------------FTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSL 911
              T++ T + C             T      +    +V    D PGP  +++  EI   S 
Sbjct: 13439 STDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSA 13498

Query: 912   KVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA 970
              V+W+ P    G  +  Y +   +  R +        + T  +RV  L    +Y   V A
Sbjct: 13499 YVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKT-SFRVANLEEGKSYFFRVFA 13557

Query: 971   MTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVE 1029
                 G G     T  +    + PGP  +L + ++   S ++ ++ P  DG + I  ++V+
Sbjct: 13558 ENEYGIGD-PGETRDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVD 13616

Query: 1030  AQVGVVGEGEEWL-LIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
                  + E  +W  ++  LS +  A+     DL     Y+FR+   N  G   PS+    
Sbjct: 13617 ----FLTEENKWQRVMKSLSLQYSAK-----DLTEGKEYTFRVSAENENGEGTPSEI--- 13664

Query: 1089  IQTLQAPPDMAPANVSLR-------TASETSLW-----LRWMPLPEMEYNGNPESVGYKI 1136
               T+ A  D+   ++ L+        A E S +     ++  P P + +    + +    
Sbjct: 13665 --TVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDT 13722

Query: 1137  KYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGS--GPWSQTVVGRT 1194
             + S           V    V     + D ++    +  +   N  G+  G  S  VVG+ 
Sbjct: 13723 RVS-----------VESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKP 13771

Query: 1195  RESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVE 1254
                +P+ GP     +  T+ +M ++W+  P+ D    +  Y  + +++DS          
Sbjct: 13772 --GIPT-GPIKFDEV--TAEAMTLKWAP-PKDDGGSEITNY--ILEKRDSVNNKWVTCAS 13823

Query: 1255  GNSSRSAQLTGLGKYVLYEVQVLAFTR--IGDGSPSHPPILERTLD--DVPGPPMGILFP 1310
                  + ++T L + + Y  +V A  +  +G+G  S P +     D  D P PP  +   
Sbjct: 13824 AVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAPPPPNIV--- 13880

Query: 1311  EVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTT----ANTATVEVLAPSARQYTATGL 1365
             +VR  SV L W  P    G  I  Y +  +   +     AN   + +     R +  TGL
Sbjct: 13881 DVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRM-----RDFKVTGL 13935

Query: 1366  KPESVYLFRITAQTRKGWGEAA---EALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW 1422
                  Y FR+ A    G G+ +   E +V      D   PP +P V   ++   SV L W
Sbjct: 13936 TEGLEYEFRVMAINLAGVGKPSLPSEPVVAL----DPIDPPGKPEVI--NITRNSVTLIW 13989

Query: 1423  -EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATND 1481
              EP  DG   +  Y ++ R+LPS  W + +  V+    +F V  L     Y+FR++A N 
Sbjct: 13990 TEPKYDGGHKLTGYIVEKRDLPSKSW-MKANHVNVPECAFTVTDLVEGGKYEFRIRAKNT 14048

Query: 1482  IGDSEFSEESESLTTLQAAPD-EAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIR 1540
              G    S  SES  T+    + EAPTI+               P  +D       G  I+
Sbjct: 14049 AG--AISAPSESTETIICKDEYEAPTIVL-------------DPTIKD-------GLTIK 14086

Query: 1541  YRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNL----SRPSLTQYELDNLNKHRRYE 1596
               + +   L   ++ G   P ++W++        ++    S P+ +   +    +    E
Sbjct: 14087 AGDTIV--LNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGE 14144

Query: 1597  IRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDI 1656
               ++  N  G    +  + V V        P  V +   +A +  +TW PP L+     I
Sbjct: 14145 YTITATNPFG----TKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP-LEDGGSPI 14199

Query: 1657  QGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTP 1714
             + Y +   E  R  L   V     +   V  K + G   Y+  V+A N  G G   +S P
Sbjct: 14200 KSYILEKRETSR-LLWTVVSEDIQSCRHVATKLIQG-NEYIFRVSAVNHYGKGEPVQSEP 14257

Query: 1715  TQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKI 1773
              +   +   P  P   + S +T  +  VSW+ P    G  + GY +       +  V  I
Sbjct: 14258 VKMVDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERREKKSLRWVRAI 14317

Query: 1774  VTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGA--PGPPGV 1830
              T      S L  KV  L EG TY FR+ A+     GP  EA+ +    + A  PGPP  
Sbjct: 14318 KTPV----SDLRCKVTGLQEGSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSN 14373

Query: 1831  PIIVRYSSAIA-IHWSSGDPGKG-PITRYVIEARPSDEGLWDILIKDIPKEVSSYT-FSM 1887
             P +   +   A + W       G  IT YV+E +   +  W   IKD        T F +
Sbjct: 14374 PHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEAW---IKDTTGTALRITQFVV 14430

Query: 1888  DILKPGVSYDFRVIAVNDYGFGTPS-SPSQSVPAQKANPFYE 1928
               L+    Y+FR+ A+ND G G P+  P   +  ++  P +E
Sbjct: 14431 PDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFE 14472



 Score =  200 bits (508), Expect = 1e-50
 Identities = 369/1617 (22%), Positives = 631/1617 (39%), Gaps = 210/1617 (12%)

Query: 477   ATNSRGVDEASADLVVWARTRITKPP-----QDQSVIKGTQASMVCGVTHDPRVTIRYIW 531
             A N+ GV + SA +      R   PP     +   V +GT  ++V  +   P  T+   W
Sbjct: 9788  AVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAKIKGVPFPTLT--W 9845

Query: 532   EKDGATLGTESHP--------RIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
              K          P        ++ +D   +L I Q+   D G YT   ++  G  S+   
Sbjct: 9846  FKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMR 9905

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLAS 642
             L V   P  P  P+    +V    + L+W  P D G S +  Y++E  E N    V ++S
Sbjct: 9906  LNVLGRPGPPVGPIK-FESVSADQMTLSWFPPKDDGGSKITNYVIEKREANRKTWVHVSS 9964

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTA--------PP 694
              +PK  + T+  L+    Y FR+ A N  G G+         L  EP TA         P
Sbjct: 9965  -EPKECTYTIPKLLEGHEYVFRIMAQNKYGIGE--------PLDSEPETARNLFSVPGAP 10015

Query: 695   QNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLL 754
                  S  T  S+ + W+ P E      + GY +           ++K +    +  + L
Sbjct: 10016 DKPTVSSVTRNSMTVNWEEP-EYDGGSPVTGYWLEMKDT---TSKRWKRVNRDPIKAMTL 10071

Query: 755   ------EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNST-- 806
                     LI  ++Y+  V A N+AG+G  S      T +  P  PPG    + T+ T  
Sbjct: 10072 GVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARD-PIAPPGPPFPKVTDWTKS 10130

Query: 807   TIRFTWNAP---SPQFINGINQGYKLIA---WEPEQEEEVTMVTARPNFQDSIHVGFVSG 860
             +    W+ P       + G    YK      WE  +++EV                 V+G
Sbjct: 10131 SADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKL-----------VVTG 10179

Query: 861   LKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEP- 918
             LK+   Y   V      G G P     ++   + +  P          D  L  S ++  
Sbjct: 10180 LKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKDRLVSP----------DLQLDASVRDRI 10229

Query: 919   -GEKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVT-GLTALTTYTI---------E 967
                  G++   RI      +    VT  +   TL    T   TA+++  +          
Sbjct: 10230 VVHAGGVI---RIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQG 10286

Query: 968   VAAMTSKGQGQVSASTISSGVPPELPGPP-TNLGISNIGPRSVTLQ-FRPGYDGKTSISR 1025
             V ++ +K +      TI   V  ++PGP  T     N+   S  L  F P  DG + I+ 
Sbjct: 10287 VYSLLAKNEAGERKKTIIVDVL-DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITN 10345

Query: 1026  WLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP 1085
             +++E +     +   W  +       +A    V  L     Y FR+   N +G  P  + 
Sbjct: 10346 YVIEKRES---DRRAWTPVTYTVTRQNAT---VQGLIQGKAYFFRIAAENSIGMGPFVET 10399

Query: 1086  SRKIQTLQAPPDMA--PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDG 1143
             S  +  ++ P  +   P ++ ++  ++ ++ L W P    +Y+G  E + Y ++ SR  G
Sbjct: 10400 SEAL-VIREPITVPERPEDLEVKEVTKNTVTLTWNP---PKYDGGSEIINYVLE-SRLIG 10454

Query: 1144  HGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWS---QTVVGRTRESVPS 1200
               K       + + R YT++ L+E   Y  +V A N +G G  S   + +  +   + P+
Sbjct: 10455 TEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPT 10514

Query: 1201  ---SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDS-DTQPRFWLVEGN 1256
                     ++     + ++  R+S  P+   +       V+  ++    T P    +E  
Sbjct: 10515 LHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALE-- 10572

Query: 1257  SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG-ILFPEVRTT 1315
                 A+ +  GKY +          + + + S     +  + D PGPP+G + F EV   
Sbjct: 10573 -KIKAKRSDSGKYCVV---------VENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKD 10622

Query: 1316  SVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESV-YLFR 1374
              + + W+PP    G  +   I  +          + V + SA+         E   Y+FR
Sbjct: 10623 YMVISWKPPLDDGGSKITNYIIEKKEV--GKDVWMPVTSASAKTTCKVSKLLEGKDYIFR 10680

Query: 1375  ITAQTRKGWGEAAEALVVTTEKRDR-PQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR 1433
             I A+   G  +   +  +  + R R P  P +P+V +  V   S L++W    DG  P+ 
Sbjct: 10681 IHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTE--VTKDSALVTWNKPHDGGKPIT 10738

Query: 1434  YYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESES 1493
              Y ++ RE  S RWA  +    H  + F V  L     Y+FRV A N+IG  + S  S+ 
Sbjct: 10739 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 10798

Query: 1494  LTTLQAAPDEAPTILSVTPHTT-TSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGF 1552
             +         +P +      TT  SV + WQPP  D     +LG+ + Y+++  E  R  
Sbjct: 10799 VFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDG-GSKILGYIVEYQKVGDEEWR-- 10855

Query: 1553  TLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSS 1611
               R  + P                S P  T+Y++  L   + Y+ R+   NA GE  P+ 
Sbjct: 10856 --RANHTPE---------------SCPE-TKYKVTGLRDGQTYKFRVLAVNAAGESDPAH 10897

Query: 1612  PPQEVFVGEAVPTAAPRNVVVHGATATQLDV-TWEPPPLDSQNGDIQGYKIYFWEAQRGN 1670
              P+ V V + +    P  +++    A +  +   +   L +    +   K+ + +  R  
Sbjct: 10898 VPEPVLVKDRL---EPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDA 10954

Query: 1671  LTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSV 1730
              T+    +    + ++++N       + S+   N AG     T +        P  P  +
Sbjct: 10955 PTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGS---KTVSVKVLVLDKPGPPRDL 11011

Query: 1731  KFSELTTTSVNVSWEAP------QFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPL 1784
             + SE+   S  ++W+ P         N ++E   +     SP+   SK      K +   
Sbjct: 11012 EVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSK-----KKSHF-- 11064

Query: 1785  WLKVKDLAEGVTYRFRIRAKT-FTYGPEIEANVTTGPGEGAP--GPPGVPIIVRY----S 1837
                 K L EG  Y FR+ A+  +  GP +E   T  P +      PPG P  + +     
Sbjct: 11065 ---AKHLNEGNQYLFRVAAENQYGRGPFVE---TPKPIKALDPLHPPGPPKDLHHVDVDK 11118

Query: 1838  SAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSY 1896
             + +++ W+  D  G  PIT Y++E +  +EG  D +     K V++    +  L+ G +Y
Sbjct: 11119 TEVSLVWNKPDRDGGSPITGYLVEYQ--EEGTQDWIKF---KTVTNLECVVTGLQQGKTY 11173

Query: 1897  DFRVIAVNDYGFGTPSSPSQSVPAQKANPFYEEWWFLVVIALVGLIFI--LLLVFVLIIR 1954
              FRV A N  G G P +   ++P +           L V  + GL+      + F  IIR
Sbjct: 11174 RFRVKAENIVGLGLPDT---TIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIR 11230

Query: 1955  GQSKKYAKKTDSGNSAKSGALGHSEMMSLDESSFPALELNNRRLSVKNSFCRKNGLY 2011
             G     AK T  G+  K+      E  +++  +F ++      L++KN   R  G Y
Sbjct: 11231 GVPVPTAKWTTDGSEIKT-----DEHYTVETDNFSSV------LTIKNCLRRDTGEY 11276



 Score =  200 bits (508), Expect = 1e-50
 Identities = 379/1720 (22%), Positives = 629/1720 (36%), Gaps = 216/1720 (12%)

Query: 124   VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAIT-LENTLVILSTVAPDAGRYY 182
             V H    +     ++  P P VTW  + R +P  + I  T + +++VI +      G Y 
Sbjct: 10230 VVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYS 10289

Query: 183   VQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANAR 242
             + A N+     KT   I + V +V GP      T  +    T+     +  + E   +  
Sbjct: 10290 LLAKNEAGERKKT---IIVDVLDVPGPVG----TPFLAHNLTNESCKLTWFSPE--DDGG 10340

Query: 243   PLIKLHIIWKKDG---VLLSGGISDHNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRG 299
               I  ++I K++           +   +  T+       A ++   A       P V   
Sbjct: 10341 SPITNYVIEKRESDRRAWTPVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETS 10400

Query: 300   AYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPP------PSITWYKDAAVVEVEK 353
               L + EP   +  PER    E+++V          PP        I +  ++ ++  EK
Sbjct: 10401 EALVIREP---ITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEIINYVLESRLIGTEK 10457

Query: 354   LTRFRQRN--DGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL-- 409
               +    N       + GL   DT  ++  A N  G+ + S      +    +    L  
Sbjct: 10458 FHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHL 10517

Query: 410   ----DSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT 465
                   T+  G +  L    SG P+P ++W K E  +        + TP       I   
Sbjct: 10518 DFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAK 10577

Query: 466   HISDAGTYTCLATNSRG----------------------VDEASADLVVWARTRITKPPQ 503
               SD+G Y  +  NS G                       DE + D +V +     KPP 
Sbjct: 10578 R-SDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVIS----WKPPL 10632

Query: 504   DQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGD 563
             D         S +     + +   + +W     +   ++  ++     G  +I +  + +
Sbjct: 10633 DDG------GSKITNYIIEKKEVGKDVW-MPVTSASAKTTCKVSKLLEGKDYIFRIHAEN 10685

Query: 564   IGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLI 623
             +   +  ++S    DS  A  R R +P AP+ P+ T   V + +  +TW KP DG  P+ 
Sbjct: 10686 LYGISDPLVS----DSMKAKDRFR-VPDAPDQPIVT--EVTKDSALVTWNKPHDGGKPIT 10738

Query: 624   RYILEMSEN-NAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTER 682
              YILE  E  +  W  +        T   V  L+    Y+FR+ A N++G G  S  ++ 
Sbjct: 10739 NYILEKRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKP 10798

Query: 683   VSLPEE-PPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF 741
             V   +     +PP N  A   T  S+ + WQPP     + IL GYI+ Y   G     + 
Sbjct: 10799 VFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKIL-GYIVEYQKVGDEEWRRA 10857

Query: 742   KNITDA-DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNV-H 799
              +  ++       +  L     Y+  V A N+AG     + V E  L      PP  +  
Sbjct: 10858 NHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGES-DPAHVPEPVLVKDRLEPPELILD 10916

Query: 800   AEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVS 859
             A       I+          I G+   +  + W+ E  +  T         D   VG   
Sbjct: 10917 ANMAREQHIKVGDTLRLSAIIKGV--PFPKVTWKKEDRDAPTKARI-----DVTPVGSKL 10969

Query: 860   GLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPG 919
              ++        +   T        T  +     D PGP   L  SEI   S  ++W+EP 
Sbjct: 10970 EIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPL 11029

Query: 920   EKNG-ILTGYRI--------SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA 970
             +  G ++T Y +         W   + T+ + +H+  +         L     Y   VAA
Sbjct: 11030 DDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKH---------LNEGNQYLFRVAA 11080

Query: 971   MTSKGQGQV--SASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWL 1027
                 G+G    +   I +  P   PGPP +L   ++    V+L + +P  DG + I+ +L
Sbjct: 11081 ENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYL 11140

Query: 1028  VEAQVGVVGEG-EEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTS-PPSQP 1085
             VE Q     EG ++W+    ++N        V  L     Y FR++  NIVG   P +  
Sbjct: 11141 VEYQ----EEGTQDWIKFKTVTN----LECVVTGLQQGKTYRFRVKAENIVGLGLPDTTI 11192

Query: 1086  SRKIQTLQAPPD-------MAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY 1138
               + Q    PP        +    V   T       +R +P+P  ++  +   +      
Sbjct: 11193 PIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI------ 11246

Query: 1139  SRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESV 1198
              ++D H      V  D      TI++         Q+   NA GS       V  T   V
Sbjct: 11247 -KTDEH----YTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGS---KTVAVHLTVLDV 11298

Query: 1199  PS--SGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLV--E 1254
             P   +GP N+  L  T   M + W + P+ D    V+ Y V    +  DT+   W V   
Sbjct: 11299 PGPPTGPINI--LDVTPEHMTISW-QPPKDDGGSPVINYIV----EKQDTRKDTWGVVSS 11351

Query: 1255  GNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVR 1313
             G+S    ++  L K   Y  +V A  +IG G P    P + +     P PP   +  ++ 
Sbjct: 11352 GSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDIT 11411

Query: 1314  TTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYL 1372
               +  + W  P +  G  I  Y +  R    T     V     +  ++  TGL   + Y 
Sbjct: 11412 ENAATVSWTLPKSDGGSPITGYYMERR--EVTGKWVRVNKTPIADLKFRVTGLYEGNTYE 11469

Query: 1373  FRITAQTRKGWGEAAEAL--VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLS 1430
             FR+ A+   G  + + +   +        P PP  P ++ +  R  + L+  +P SDG S
Sbjct: 11470 FRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKS-RETADLVWTKPLSDGGS 11528

Query: 1431  PVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEE 1490
             P+  Y ++ ++  + +W   +        +F V  L     Y+FR+KA N +G+ E  E 
Sbjct: 11529 PILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPREL 11588

Query: 1491  SESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLR 1550
             +ES+         A  IL   P     V  R        +  + +G  IR          
Sbjct: 11589 AESVI--------AKDILH-PPEVELDVTCR-------DVITVRVGQTIRILA------- 11625

Query: 1551  GFTLRGINNPGATWAELTSMY-------SMRNLSRPSLTQYELDNLNKHRRYEIRMSVYN 1603
                ++G   P  TW +   +         +++L R  L   E    + H +Y I  S  N
Sbjct: 11626 --RVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRAD-HGKYII--SAKN 11680

Query: 1604  AVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYF 1663
             + G    S      V         +N+ V   T     ++WE  PLD+   +I  + + +
Sbjct: 11681 SSGHAQGS----AIVNVLDRPGPCQNLKVTNVTKENCTISWE-NPLDNGGSEITNFIVEY 11735

Query: 1664  -------WEAQRGNLTER-VKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP---RS 1712
                    W     ++T+R +K   LA N            Y   V A N  G GP     
Sbjct: 11736 RKPNQKGWSIVASDVTKRLIKANLLANNE-----------YYFRVCAENKVGVGPTIETK 11784

Query: 1713  TPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
             TP         P  P ++  ++   T V + W  P +  G
Sbjct: 11785 TPILAINPIDRPGEPENLHIADKGKTFVYLKWRRPDYDGG 11824



 Score =  198 bits (503), Expect = 5e-50
 Identities = 328/1450 (22%), Positives = 557/1450 (38%), Gaps = 178/1450 (12%)

Query: 523   PRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSA 582
             P+VT    W K G            +D    L I  +   D G Y+  +++  G  +   
Sbjct: 12331 PKVT----WRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFV 12386

Query: 583   HLRVRQLPHAPEHPVATL--STVERRAINLTWTKPF-DGNSPLIRYILEMSE-NNAPWTV 638
             ++RV   P     PV+ L  S V + + +++W  P  DG S +  YI+E  E +   W+ 
Sbjct: 12387 NVRVLDTPG----PVSDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWST 12442

Query: 639   LLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTA--PPQN 696
             +   V  K TS  V  LVP   Y FR+ AVN+ G G    D  +  L  +P +   PP+ 
Sbjct: 12443 VTPEV--KKTSFHVTNLVPGNEYYFRVTAVNEYGPG-VPTDVPKPVLASDPLSEPDPPRK 12499

Query: 697   VIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLED 756
             +  +  T  S  + W PP        + GYI  Y     P     +     D+ +L++  
Sbjct: 12500 LEVTEMTKNSATLAWLPPLRD-GGAKIDGYITSYREEEQPADRWTEYSVVKDL-SLVVTG 12557

Query: 757   LIIWTNYEIEVAAYNSAGL-------GVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIR 809
             L     Y+  VAA N+ G+       GVY +K     L     + P  +  +A     I 
Sbjct: 12558 LKEGKKYKFRVAARNAVGVSLPREAEGVYEAKE---QLLPPKILMPEQITIKAGKKLRIE 12614

Query: 810   -FTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYF 868
                +  P P              W+  ++E VT      +  DS  +  +  + +    +
Sbjct: 12615 AHVYGKPHP-----------TCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGY 12663

Query: 869   TSVLCFTTPGDGPRSTPQLVRTHEDVPG-PVGHLSFSEILDTSLKVSWQEPGEKNGI-LT 926
              S+    + G   +    +V    D PG P      S+I   +  +SW  P E  G  +T
Sbjct: 12664 YSLTAENSSGTDTQKIKVVVM---DAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNIT 12720

Query: 927   GYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTIS 985
              Y +   + +R +  VT          RV  L     Y   V A    G  + +++  + 
Sbjct: 12721 NYIVEKCDVSRGDW-VTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMV 12779

Query: 986   SGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLI 1044
             +  P  +P  P N  ++ +    + + + RP  DG + I  +L+E +       E   L+
Sbjct: 12780 AQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERK-------ERNSLL 12832

Query: 1045  HQLSNEPDARSMEVP--DLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQT-LQAPPDMAPA 1101
                +N+   RS E P   L     YSFR+  +N  G+SPPS+P+  +   +   P   P 
Sbjct: 12833 WVKANDTLVRSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPE 12892

Query: 1102  NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV-ERDY 1160
              + +  ++ + +W R       +++G  + +GY ++  +  G      +    ++ + +Y
Sbjct: 12893 VIDVTKSTVSLIWAR------PKHDGGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEY 12946

Query: 1161  TIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRW 1220
             T   LEE  +Y+ +  A  A+   P S+     T   +  + P  +       S + V+ 
Sbjct: 12947 TATGLEEKAQYQFRAIARTAVNISPPSEPSDPVT--ILAENVPPRIDLSVAMKSLLTVKA 13004

Query: 1221  SEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLG-KYVLYEVQVLAF 1279
                       + L   V  K   + +    W  +G   + A+   +  +  L  +++ + 
Sbjct: 13005 G-------TNVCLDATVFGKPMPTVS----WKKDGTLLKPAEGIKMAMQRNLCTLELFSV 13053

Query: 1280  TRIGDG---------SPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI 1330
              R   G         S S    ++  + D PGPP  +   ++ +    L W+PP    G 
Sbjct: 13054 NRKDSGDYTITAENSSGSKSATIKLKVLDKPGPPASVKINKMYSDRAMLSWEPPLEDGGS 13113

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAA-EA 1389
              +   I  +  T+  N A V    P     +   L     Y FRI A+ + G G+     
Sbjct: 13114 EITNYIVDKRETSRPNWAQVSATVP-ITSCSVEKLIEGHEYQFRICAENKYGVGDPVFTE 13172

Query: 1390  LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWA 1448
               +     D P     P++   ++    + +SW+ P  DG SP+  Y ++ RE  +  W 
Sbjct: 13173 PAIAKNPYDPPGRCDPPVI--SNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWT 13230

Query: 1449  LHSASVSHNASSFIVDR------LKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA-P 1501
               +          I++R      L+  T Y+FRV A N  G  + S+ S++        P
Sbjct: 13231 KVNRKP-------IIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYP 13283

Query: 1502  DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
                P    V   T +SV + W  PA D  + I+                G+ +       
Sbjct: 13284 PGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPII----------------GYLVEVKRADS 13327

Query: 1562  ATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVG-EGPSSPPQE----- 1615
               W       +++       T++E+  L +  +Y+ R+   N +G   PS  P +     
Sbjct: 13328 DNWVRCNLPQNLQK------TRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKD 13381

Query: 1616  -VFVGEAVPTAAPRNVVVHGATATQ---LDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNL 1671
              +   E    A  R  ++  A  T    + V   PPP           KI  W     NL
Sbjct: 13382 ILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPP-----------KI-TWSKPNVNL 13429

Query: 1672  TERV-----KTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSA 1726
              +R+      T F  +  ++ +N+  Y A    +   N+ G   +   T        P  
Sbjct: 13430 RDRIGLDIKSTDF--DTFLRCENVNKYDAGKYILTLENSCG---KKEYTIVVKVLDTPGP 13484

Query: 1727  PSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWL 1786
             P +V   E++  S  V+WE P    G      +V +  +     S + T   K +     
Sbjct: 13485 PVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKSWSTVTTECSKTS----F 13540

Query: 1787  KVKDLAEGVTYRFRIRAKT-FTYGPEIEANVTTGPGEGAPGPPGVPIIVR--YSSAIAIH 1843
             +V +L EG +Y FR+ A+  +  G   E        +  PGP  V + VR    S+ +I 
Sbjct: 13541 RVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQ-TPGPV-VDLKVRSVSKSSCSIG 13598

Query: 1844  WSS-GDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
             W      G   I  YV++   ++E  W  ++K +     S  +S   L  G  Y FRV A
Sbjct: 13599 WKKPHSDGGSRIIGYVVDFL-TEENKWQRVMKSL-----SLQYSAKDLTEGKEYTFRVSA 13652

Query: 1903  VNDYGFGTPS 1912
              N+ G GTPS
Sbjct: 13653 ENENGEGTPS 13662



 Score =  195 bits (495), Expect = 5e-49
 Identities = 428/1972 (21%), Positives = 746/1972 (37%), Gaps = 272/1972 (13%)

Query: 76    YMITSLDRTHAGFYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAP 135
             ++++ L      F+R    N+ G    R+  + V      E  E            +RA 
Sbjct: 20127 HVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSHTVYVRAG 20186

Query: 136   R-------IASFPQPQVTWFRDGRKIPPSSRI--AITLEN-TLVILSTVAPDAGRYYVQA 185
                     I+  P P+VT  RDG  +  + R    IT EN T+ +  +V  DAGRY + A
Sbjct: 20187 SNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITA 20246

Query: 186   VNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVA--------GTSEVTLEC 237
              N       T   I + V +  GP  P  P +I      SV          G S+VT   
Sbjct: 20247 ANSSG---TTKAFINIVVLDRPGP--PTGPVVISDITEESVTLKWEPPKYDGGSQVTNYI 20301

Query: 238   VANARPLIKLHIIWKKDGVLLSGGI---------SDHNRRLTIPNPTG-SDAGYYECEAV 287
             +           +W +    ++  +          ++  R+   N  G SD     C  V
Sbjct: 20302 LLKRETSTA---VWTEVSATVARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTV 20358

Query: 288   LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
                 + P      +++ +            ++     VV    + K     SI W K   
Sbjct: 20359 KLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSAVVGYHLEMKD--RNSILWQKANK 20416

Query: 348   VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTS--------------- 392
             +V   + T F+         +GL+ +    F+ +A NAAG  + S               
Sbjct: 20417 LVI--RTTHFKVTTIS----AGLIYE----FRVYAENAAGVGKPSHPSEPVLAIDACEPP 20466

Query: 393   TYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRF 452
               + +T I+ N           DG S +          P   W K              F
Sbjct: 20467 RNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKAS------------F 20514

Query: 453   TPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV-------VWARTRITKPPQDQ 505
             T +     +IS    +    +   A N+ G     +++V        +    I  P +  
Sbjct: 20515 TNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYT 20574

Query: 506   SVIK---GTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRN-GSLHISQTWS 561
              V+K   GT   +  G++  P  TI   W KD   L T +   +    +  S+ I     
Sbjct: 20575 EVVKYRAGTSVKLRAGISGKPAPTIE--WYKDDKELQTNALVCVENTTDLASILIKDADR 20632

Query: 562   GDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNS 620
              + G Y  ++ +A G+ S +  +++   P  P  P+    TV    I L W  P D G +
Sbjct: 20633 LNSGCYELKLRNAMGSASATIRVQILDKPGPPGGPIE-FKTVTAEKITLLWRPPADDGGA 20691

Query: 621   PLIRYILEMSENN-APWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKD 679
              +  YI+E  E +   W+++   ++     +T   ++    Y FR+ AVN  G G+  + 
Sbjct: 20692 KITHYIVEKRETSRVVWSMVSEHLEE--CIITTTKIIKGNEYIFRVRAVNKYGIGEPLES 20749

Query: 680   TERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYII----RYCLAGL 735
                V+        PP     +  T  S+ + W  P     + I  GY +    +  L   
Sbjct: 20750 DSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDI-SGYFLEKRDKKSLGWF 20808

Query: 736   PVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPP 795
              V  +    T   V  L        ++Y+  V A N+AG G +S   +E+     P  PP
Sbjct: 20809 KVLKETIRDTRQKVTGLTEN-----SDYQYRVCAVNAAGQGPFSEP-SEFYKAADPIDPP 20862

Query: 796   G---NVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDS 852
             G    +    +  ++I   W+ P     + +  GY ++     +EEE T V+ +   + +
Sbjct: 20863 GPPAKIRIADSTKSSITLGWSKPVYDGGSAVT-GY-VVEIRQGEEEEWTTVSTKGEVRTT 20920

Query: 853   IHVGFVSGLKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFSEI-LDTS 910
              +V  VS LK    Y+  V      G G P    + V+  + +  P       EI LD +
Sbjct: 20921 EYV--VSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAP-------EIDLDVA 20971

Query: 911   LKVSW-QEPGEKNGILTGYR------ISWEEYNRTNTRVTHY-LPNVTLEYRVTGLTALT 962
             L+ S   + GE   +L  ++      ++W +  +       Y + N      +T      
Sbjct: 20972 LRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTR 21031

Query: 963   TYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKT 1021
               T +       G G+  +ST+S  V  + P     L + ++   +VTL + P   DG +
Sbjct: 21032 NDTGKYILTIENGVGEPKSSTVSVKVL-DTPAACQKLQVKHVSRGTVTLLWDPPLIDGGS 21090

Query: 1022  SISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSP 1081
              I  +++E +         W ++   S++  + S ++ DL+  T + FR+   N +G   
Sbjct: 21091 PIINYVIEKRDATK---RTWSVV---SHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGE 21144

Query: 1082  PSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRS 1141
             P + +  ++  + P  +   ++S++ +++TS+ L W    + +++G      Y ++  R 
Sbjct: 21145 PCETTEPVKAAEVPAPIR--DLSMKDSTKTSVILSWT---KPDFDGGSVITEYVVE--RK 21197

Query: 1142  DGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESVPS 1200
                 +T SH    +   +  +  L+E +    +V A N  G S P              +
Sbjct: 21198 GKGEQTWSHAGISKT-CEIEVSQLKEQSVLEFRVFAKNEKGLSDP-------------VT 21243

Query: 1201  SGPTNVSALATTSSSMLVRWSEVPEAD---RNGLVLGYKVMYKEKDSDTQPRFWLVEGNS 1257
              GP  V  L  T     V  S++P A    R G  +  ++ YK K   +    WL +G  
Sbjct: 21244 IGPITVKELIITPE---VDLSDIPGAQVTVRIGHNVHLELPYKGKPKPSIS--WLKDGLP 21298

Query: 1258  SRSAQLTGLGKY---VLYEVQVLA------FTRIGDGSPSH--PPILERTLDDVPGPPMG 1306
              + ++     K    +   ++         +T I D +      PI   TL     P   
Sbjct: 21299 LKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPITVITLGPPSKPKGP 21358

Query: 1307  ILFPEVRTTSVRLIWQPPAAPNG-IILAYQITHRLNTTTANTATVEVLAPSARQ-YTATG 1364
             I F E++  SV L W  P    G  I  Y I  R    T+ T    V +  AR  +    
Sbjct: 21359 IRFDEIKADSVILSWDVPEDNGGGEITCYSIEKR---ETSQTNWKMVCSSVARTTFKVPN 21415

Query: 1365  LKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDR-PQPPSRPMVQQEDVRARSVLLSWE 1423
             L  ++ Y FR+ A+ R G  +   + ++  + + R P PP +P++   +V +  + L+W+
Sbjct: 21416 LVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIY--NVTSDGMSLTWD 21473

Query: 1424  -PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDI 1482
              P  DG S V  + ++ +E  S  W   + S   +   +    L     Y+FRV A N  
Sbjct: 21474 APVYDGGSEVTGFHVEKKERNSILWQKVNTSPI-SGREYRATGLVEGLDYQFRVYAENSA 21532

Query: 1483  GDSEFSEESE-SLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRY 1541
             G S  S+ S+ +L      P   P  + VT  T T   ++W PP  D  + I+ G+ I  
Sbjct: 21533 GLSSPSDPSKFTLAVSPVDPPGTPDYIDVTRETIT---LKWNPPLRDGGSKIV-GYSIEK 21588

Query: 1542  RELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSV 1601
             R+                    W          N +  S  QY +  L+   RYE R+  
Sbjct: 21589 RQ----------------GNERWVRC-------NFTDVSECQYTVTGLSPGDRYEFRIIA 21625

Query: 1602  YNAVGEGPSSPPQE-----VFVGEAVPTAAP------RNVVVHGATATQLDVTWEPPPLD 1650
              NAVG    SPP +     +   E VP            +++    + ++    +  P+ 
Sbjct: 21626 RNAVGT--ISPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVP 21683

Query: 1651  SQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGP 1710
                    G +I     +R N+     T  L   S+ +++ T     + +V A NA+G   
Sbjct: 21684 RVTWFKDGVEI----EKRMNMEI---TDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAK 21736

Query: 1711  RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGV 1770
                  + Q        P  ++F+ +T   + + W+AP            + + C+P+   
Sbjct: 21737 AEIKVKVQDTPGKVVGP--IRFTNITGEKMTLWWDAP------------LNDGCAPITHY 21782

Query: 1771  SKIVTVDVKGNSPL-WLKVKDLAE-----------GVTYRFRIRA-KTFTYGPEIEANVT 1817
                  ++ +  S L W  ++D  E           G  Y+FR+ A   F  G  ++++  
Sbjct: 21783 ----IIEKRETSRLAWALIEDKCEAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPV 21838

Query: 1818  TGPGE-GAPGPPGVPIIVRYS-SAIAIHWSSGDP-GKGPITRYVIEARPSDEGLWDILIK 1874
                 +   P  PG+P     + ++I + W+  +  G   I +Y++E R      W  +I 
Sbjct: 21839 VAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVIS 21898

Query: 1875  DIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQK-ANP 1925
               P  +S   F +  L  G  Y+F V+A N  G G  S  S+ +  ++  NP
Sbjct: 21899 KRP--ISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNP 21948



 Score =  193 bits (490), Expect = 2e-48
 Identities = 350/1604 (21%), Positives = 572/1604 (35%), Gaps = 169/1604 (10%)

Query: 378   FQCFARNAAGEVQTSTYLAVTS---IAPNIT-RGPLDSTVI--DGMSVVLACETSGAPRP 431
             F+  A N  GE   S    V     +AP++  +G  D   +  +  +  L     G P P
Sbjct: 13648 FRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAP 13707

Query: 432   AITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLV 491
             +++W+KGE  LA+   ++   +   + +L++     SDAG YT    N  G  E +  + 
Sbjct: 13708 SVSWKKGEDPLAT-DTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIK 13766

Query: 492   VWARTRITKPPQDQSVIKGTQASMVCGVTHDP--RVTIRYIWEK----DGATLGTESHPR 545
             V  +  I   P     +     ++      D        YI EK    +   +   S  +
Sbjct: 13767 VVGKPGIPTGPIKFDEVTAEAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAVQ 13826

Query: 546   IRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVER 605
                 R   LH    ++  +       +  G             +P AP  P   +  V  
Sbjct: 13827 KTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVARHPFDVPDAP--PPPNIVDVRH 13884

Query: 606   RAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFR 664
              +++LTWT P   G SP+  Y LE  E N+           +     V GL     Y+FR
Sbjct: 13885 DSVSLTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFR 13944

Query: 665   LCAVNDVGKGQFSKDTERVSLPEEP-----PTAPPQNVIASGRTNQSIMIQWQPPPESHQ 719
             + A+N  G G       + SLP EP     P  PP        T  S+ + W  P   + 
Sbjct: 13945 VMAINLAGVG-------KPSLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEP--KYD 13995

Query: 720   NG-ILKGYIIRYCLAGLPVGYQFK-NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGV 777
              G  L GYI+      LP     K N  +       + DL+    YE  + A N+AG   
Sbjct: 13996 GGHKLTGYIVE--KRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAIS 14053

Query: 778   YSSKVTEW----------TLQGVPTVPPG-NVHAEATNSTTIRFTWNAPSPQFINGINQG 826
               S+ TE           T+   PT+  G  + A  T           P P+  +  ++ 
Sbjct: 14054 APSESTETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPK--SSWSKA 14111

Query: 827   YKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQ 886
              K I     +  ++T +T+ P          +  +K  T         T           
Sbjct: 14112 GKDI-----RPSDITQITSTP-------TSSMLTIKYATRKDAGEYTITATNPFGTKVEH 14159

Query: 887   LVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTRVTHY 945
             +  T  DVPGP G +  S +      ++W  P E  G  +  Y +   E +R    V   
Sbjct: 14160 VKVTVLDVPGPPGPVEISNVSAEKATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSE 14219

Query: 946   LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQ-VSASTISSGVPPELPGPPTNLGISNI 1004
                 +  +  T L     Y   V+A+   G+G+ V +  +        PGPP    +SN+
Sbjct: 14220 -DIQSCRHVATKLIQGNEYIFRVSAVNHYGKGEPVQSEPVKMVDRFGPPGPPEKPEVSNV 14278

Query: 1005  GPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNP 1063
                + T+ + RP  DG + I+ + VE +     E +    +  +         +V  L  
Sbjct: 14279 TKNTATVSWKRPVDDGGSEITGYHVERR-----EKKSLRWVRAIKTPVSDLRCKVTGLQE 14333

Query: 1064  FTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAP-PDMAPANVSLRTASETSLWLRWMPLPE 1122
              + Y FR+   N  G  PPS+ S  +    A  P   P+N  +   ++ S  L W    +
Sbjct: 14334 GSTYEFRVSAENRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAW---GK 14390

Query: 1123  MEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG 1182
               Y+G  E  GY +++ +                   + + DL+   +Y  ++ A N  G
Sbjct: 14391 PHYDGGLEITGYVVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAG 14450

Query: 1183  SGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEK 1242
              G   +  V    E V      +    A    +++VR             L  ++    K
Sbjct: 14451 VG---EPAVIPDVEIVEREMAPDFELDAELRRTLVVRAG-----------LSIRIFVPIK 14496

Query: 1243  DSDTQPRFWLVEG-NSSRSAQLTGLGKYVL--------YEVQVLAFTRIGDGSPSHPPIL 1293
                     W  +  N    A +     + L        Y+      T           + 
Sbjct: 14497 GRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVN 14556

Query: 1294  ERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVL 1353
              R L D PGP + +   ++   SV L W  P    G  +   I  +   T  + +T    
Sbjct: 14557 VRVL-DTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTK 14615

Query: 1354  APSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRP-MVQQED 1412
                   Y  TGL     Y FR+ A+   G GE  E    TTE     + PS P  +   D
Sbjct: 14616 CHKC-TYKVTGLSEGCEYFFRVMAENEYGIGEPTE----TTEPVKASEAPSPPDSLNIMD 14670

Query: 1413  VRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTS 1471
             +   +V L+W +P  DG S +  Y I+ +   S +W  H  +V       +V  L     
Sbjct: 14671 ITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWT-HITTV--KGLECVVRNLTEGEE 14727

Query: 1472  YKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKIN 1531
             Y F+V A N  G S                          P  +  V+++ Q    +   
Sbjct: 14728 YTFQVMAVNSAGRS-------------------------APRESRPVIVKEQTMLPE--- 14759

Query: 1532  GILLGFRIRYRELLY----EGLR-GFTLRGINNPGATWAELTSMYSM-RNLSRPSLTQYE 1585
                L  R  Y++L+     + ++    + G   P  TW +   +    + ++  +     
Sbjct: 14760 ---LDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATST 14816

Query: 1586  LDNLNKHRRYE---IRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDV 1642
             + N+N+  R +     ++  N VGE       +V      PT     +     ++  +  
Sbjct: 14817 ILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGP---IKFDEVSSDFVTF 14873

Query: 1643  TWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAA 1702
             +W+PP  D     I  Y +   +       E   T+     + K   LT    Y   V A
Sbjct: 14874 SWDPPENDG-GVPISNYVVEMRQTDSTTWVELATTVI--RTTYKATRLTTGLEYQFRVKA 14930

Query: 1703  FNAAGDGPRSTPT--QGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRL 1759
              N  G GP  T            P  P + + + +T  S+ +SW  P    G  + GY +
Sbjct: 14931 QNRYGVGPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHV 14990

Query: 1760  VYEPCSPV--DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVT 1817
               +  + +    VSK +   V GN     K   L +G+ Y FR+ A+      +      
Sbjct: 14991 ERKERNGILWQTVSKAL---VPGNI---FKSSGLTDGIAYEFRVIAENMAGKSKPSKPSE 15044

Query: 1818  TGPGEGAPGPPGVPIIVRYS-SAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKD 1875
                      PPG P+ +  +   + + W+  +  G   IT Y++E R    G W   +K 
Sbjct: 15045 PMLALDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRW---LKA 15101

Query: 1876  IPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG-FGTPSSPSQSV 1918
                 +    F++  L    +Y+FRVIA N  G    PS PS ++
Sbjct: 15102 NFSNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAI 15145



 Score =  193 bits (490), Expect = 2e-48
 Identities = 343/1510 (22%), Positives = 596/1510 (39%), Gaps = 171/1510 (11%)

Query: 473   YTCLATNSRG-VDEASADLVVWARTRITKPP-----QDQSVIKGTQASMVCGVTHDPRVT 526
             +  +A N +G  D  S  + + A+  + +P         SV  G    +   ++  P+ T
Sbjct: 16896 FRVVAVNEKGRSDPRSLAVPIVAKDLVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPT 16955

Query: 527   IRYIWEKDGATLGTESHPRIR--LDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHL 584
             I   W KDG  L   +   +   LD   +L I +T   D G Y   V +  G  + S  +
Sbjct: 16956 IT--WTKDGLPLKQTTRINVTDSLDLT-TLSIKETHKDDGGQYGITVANVVGQKTASIEI 17012

Query: 585   RVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP-WTVLLAS 642
                  P  P+ PV     V   +I L+W  P + G   +  YI++  +     W V+ A+
Sbjct: 17013 VTLDKPDPPKGPVK-FDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSAT 17071

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERV--SLPEEPPTAPPQNVIAS 700
             V    T++ V  L     YQFR+ A N  G+  F+ +++ +    P + P  PP    A+
Sbjct: 17072 V--ARTTLKVTKLKTGTEYQFRIFAENRYGQS-FALESDPIVAQYPYKEP-GPPGTPFAT 17127

Query: 701   GRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLED---- 756
               +  S++IQW  P  +  + ++  ++ R          +  +I    VN  ++ D    
Sbjct: 17128 AISKDSMVIQWHEPVNNGGSPVIGYHLERK---------ERNSILWTKVNKTIIHDTQFK 17178

Query: 757   ---LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWN 813
                L     YE  V A N  G+G  +SK +E  +   P  PPG           I   W 
Sbjct: 17179 AQNLEEGIEYEFRVYAENIVGVGK-ASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWT 17237

Query: 814   APSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVL 872
              P        + G  +  +  E+ +       + +F + I   F VSGL +   Y   V+
Sbjct: 17238 KPV------YDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVI 17291

Query: 873   CFTTPG--DGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRI 930
                  G    P  +   +   ++V  P   +S       ++ V+  E       + G  +
Sbjct: 17292 AKNAAGAISKPSDSTGPITAKDEVELP--RISMDPKFRDTIVVNAGETFRLEADVHGKPL 17349

Query: 931   SWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI--SSGV 988
                E+ R +  +     +   E + T   AL    ++ A     GQ  + AS +  S   
Sbjct: 17350 PTIEWLRGDKEIEE---SARCEIKNTDFKALLI--VKDAIRIDGGQYILRASNVAGSKSF 17404

Query: 989   PPEL-----PGPPTN-LGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVGVVGEGEEW 1041
             P  +     PGPP   + ++ +     +L + P   DG + IS ++VE +         W
Sbjct: 17405 PVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHYVVEKRET---SRLAW 17461

Query: 1042  LLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPA 1101
              ++   ++E    S++V  L     Y FR+  VN  G   P + +  +          P 
Sbjct: 17462 TVV---ASEVVTNSLKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPK 17518

Query: 1102  NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV-ERDY 1160
             ++ +   ++ S+ + W      + +G  E +GY ++  + D  G       + R+ +   
Sbjct: 17519 SLEVTNIAKDSMTVCWN---RPDSDGGSEIIGYIVE--KRDRSGIRWIKCNKRRITDLRL 17573

Query: 1161  TIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRTRESVPSSGP-TNVSALATTSSSMLV 1218
              +  L E  EY  +V A NA G G P   TV  +  + V   GP TN   + TT +S+ +
Sbjct: 17574 RVTGLTEDHEYEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITL 17633

Query: 1219  RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA 1278
              W + P  D    +LGY V   + D +         G      +++ L ++  Y+++V A
Sbjct: 17634 AWGK-PIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCA 17692

Query: 1279  FTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITH 1338
               ++G G  +  P   +  D +  P +  L  E+R               GI++    + 
Sbjct: 17693 LNKVGLGEATSVPGTVKPEDKLEAPELD-LDSELR--------------KGIVVRAGGSA 17737

Query: 1339  RLNTTTANTATVEVL-APSARQYTATGLKPESVYLFRITAQT--RKGWGE---------A 1386
             R++       T E+  +    ++T      + V   +++     R   G+          
Sbjct: 17738 RIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG 17797

Query: 1387  AEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSG 1445
             +++  VT +  D P PP    V++  VR  S  L WEP   DG + V+ Y I  RE  S 
Sbjct: 17798 SKSAFVTVKVLDTPGPPQNLAVKE--VRKDSAFLVWEPPIIDGGAKVKNYVIDKRE--ST 17853

Query: 1446  RWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAP 1505
             R A  + S   + +SF V+ L     Y FRV A N+ G     E  +++    A P   P
Sbjct: 17854 RKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKA--AEPPSPP 17911

Query: 1506  TILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWA 1565
               +++T  + TS  + W+ P  D  + +L G+ +   E+  +G   +++           
Sbjct: 17912 GKVTLTDVSQTSASLMWEKPEHDGGSRVL-GYVV---EMQPKGTEKWSI----------- 17956

Query: 1566  ELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVP-- 1623
                       ++   +    +  L+  + Y+ R+  YN  G+   S P+ + V       
Sbjct: 17957 ----------VAESKVCNAVVTGLSSGQEYQFRVKAYNEKGK---SDPRVLGVPVIAKDL 18003

Query: 1624  TAAPRNVVVHGATATQL--DVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLA 1681
             T  P   +     + Q   D+  E P +     +I   K    + +    T RV     A
Sbjct: 18004 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVK----DGEPLKQTTRVNVEETA 18059

Query: 1682  ENSV---KLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
              ++V   K  N   +  Y  +V A N+AG    +       +   P  P  V+F E++  
Sbjct: 18060 TSTVLHIKEGNKDDFGKY--TVTATNSAGTATENLSVIVLEKPGPPVGP--VRFDEVSAD 18115

Query: 1739  SVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTY 1797
              V +SWE P +  G  +  Y  + E          +V+  V   +   +K+  L  G  Y
Sbjct: 18116 FVVISWEPPAYTGGCQISNY--IVEKRDTTTTTWHMVSATVARTT---IKITKLKTGTEY 18170

Query: 1798  RFRIRAKTFTYGP----EIEANVTTGPGEGAPGPPGVPIIVRYSS-AIAIHWSSG-DPGK 1851
             +FRI A+   YG     + +A +   P +  PGPPG P +   S   + + W    + G 
Sbjct: 18171 QFRIFAEN-RYGKSAPLDSKAVIVQYPFK-EPGPPGTPFVTSISKDQMLVQWHEPVNDGG 18228

Query: 1852  GPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP 1911
               I  Y +E +  +  LW  L K   ++    T  +D    G+ Y+F+V A N  G G P
Sbjct: 18229 TKIIGYHLEQKEKNSILWVKLNKTPIQDTKFKTTGLD---EGLEYEFKVSAENIVGIGKP 18285

Query: 1912  SSPSQSVPAQ 1921
             S  S+   A+
Sbjct: 18286 SKVSECFVAR 18295



 Score =  192 bits (489), Expect = 2e-48
 Identities = 323/1397 (23%), Positives = 511/1397 (36%), Gaps = 198/1397 (14%)

Query: 547   RLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERR 606
             R +    L I +    D GTYT    +  G+  R+ H+ V   P  P +   T   ++  
Sbjct: 9150  RSEAKTELSIPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDRPSPPRNLAVT--DIKAE 9207

Query: 607   AINLTWTKPFD-GNSPLIRYILEM---SENNAPWTVLLASVDPKATSVTVKGLVPARSYQ 662
             +  LTW  P D G S +  Y+++    S   A W  +  +   K   +    L+P   Y+
Sbjct: 9208  SCYLTWDAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWK--LIPNGQYE 9265

Query: 663   FRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGI 722
             FR+ AVN  G     K  + V         PP       RT  S+++ W PP ++  + I
Sbjct: 9266  FRVRAVNKYGISDECKSDKVVIQDPYRLPGPPGKPKVLARTKGSMLVSWTPPLDNGGSPI 9325

Query: 723   LKGYIIRYCLAGLPVGYQFKNITDADVNNLLLED-------LIIWTNYEIEVAAYNSAGL 775
               GY +     G P    +  ++ A +  + L+        L+    Y+    A N+AG+
Sbjct: 9326  -TGYWLEKREEGSP---YWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGI 9381

Query: 776   GVYSSKVTEWTLQGVPTVPPGNVHAEATNSTT---IRFTWNAPSPQFINGINQGYKLIAW 832
             G   S+ ++  + G P  PPG          T   I   W  P+       + G  +  +
Sbjct: 9382  GP-PSEPSDPEVAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAK------DGGSPIKGY 9434

Query: 833   EPEQEEEVTMVTARPNFQDSIHVG---FVSGLKKFTEYFTSVLCFTTPGDGPRS--TPQL 887
               E +EE T    R N  D +       V  LK+  +Y   V      G+   S  T ++
Sbjct: 9435  IVEMQEEGTTDWKRVNEPDKLITTCECVVPNLKELRKYRFRVKAVNEAGESEPSDTTGEI 9494

Query: 888   VRTH-EDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTHYL 946
               T  ++ P     +   + L        + P    G  T  + SWE   +    +   +
Sbjct: 9495  PATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTP-KSSWEFDGKAKKAMKDGV 9553

Query: 947   PNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSA------STISSGVP-PELPGPPTNL 999
              ++  + ++      +   I     +  G+  ++A       T +  V   ++PGPP +L
Sbjct: 9554  HDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAGQKTANCRVKVMDVPGPPKDL 9613

Query: 1000  GISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARS--M 1056
              +S+I   S  L ++ P  DG   I  +++E +     +G+ W  ++     PD  S   
Sbjct: 9614  KVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKR---TIDGKAWTKVN-----PDCGSTTF 9665

Query: 1057  EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQA--PPDMAPANVSLRTASETSLW 1114
              VPDL     Y FR+R  N  G  PP +  ++        PPD  P  + +   ++ ++ 
Sbjct: 9666  VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPD-PPIKLKIGLITKNTVH 9724

Query: 1115  LRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQ----DRVERDYTIEDLEEWTE 1170
             L W P    + +G      Y ++    D  G       Q    D  E  +T+EDL E  E
Sbjct: 9725  LSWKP---PKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRDVEELQFTVEDLVEGGE 9781

Query: 1171  YRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNG 1230
             Y  +V+A NA G    S TV           GP +        S  L  + EV E     
Sbjct: 9782  YEFRVKAVNAAGVSKPSATV-----------GPCDCQRPDMPPSIDLKEFMEVEEGTNVN 9830

Query: 1231  LV-----------LGYKVMYKEKDS------DTQPRFWLVEGNSSRSAQLTGLGKYVLYE 1273
             +V             +K   K+ D+      DT     +V+   +     +      LY 
Sbjct: 9831  IVAKIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLY- 9889

Query: 1274  VQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIIL 1332
               + A   +G  S      +   +   PGPP+G I F  V    + L W PP    G  +
Sbjct: 9890  -TITAVNNLGTASKE----MRLNVLGRPGPPVGPIKFESVSADQMTLSWFPPKDDGGSKI 9944

Query: 1333  AYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVV 1392
                +  +          V    P    YT   L     Y+FRI AQ + G GE  ++   
Sbjct: 9945  TNYVIEKREANRKTWVHVS-SEPKECTYTIPKLLEGHEYVFRIMAQNKYGIGEPLDSEPE 10003

Query: 1393  TTEKR-DRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALH 1450
             T       P  P +P V    V   S+ ++W EP  DG SPV  Y ++ ++  S RW   
Sbjct: 10004 TARNLFSVPGAPDKPTV--SSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRV 10061

Query: 1451  SASVSHNAS---SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI 1507
             +       +   S+ V  L   + Y+FRV A N  G    S  S+  T         P  
Sbjct: 10062 NRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPF 10121

Query: 1508  LSVTPHTTTSVLIRWQPPAED---KINGILLGFR--------------IRYRELLYEGL- 1549
               VT  T +S  + W PP +D   K+ G ++ ++              +R  +L+  GL 
Sbjct: 10122 PKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLK 10181

Query: 1550  ---------RGFTLRGINNPGATWAELTSMYSMRN-LSRP--SLTQYELDNLNKHRRYEI 1597
                      R   + GI  PG    E+T +  M++ L  P   L     D +  H    I
Sbjct: 10182 EGAFYKFRVRAVNIAGIGEPG----EVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVI 10237

Query: 1598  RMSVYNAVGEGPS--------SPPQEVFV------------------------------G 1619
             R+  Y +    P+        + PQE  +                              G
Sbjct: 10238 RIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAG 10297

Query: 1620  EA----------VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRG 1669
             E           VP       + H  T     +TW  P  D     I  Y I   E+ R 
Sbjct: 10298 ERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPE-DDGGSPITNYVIEKRESDRR 10356

Query: 1670  NLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQG---QTQQAAPSA 1726
               T    T  +   +  ++ L    AY   +AA N+ G GP    ++    +     P  
Sbjct: 10357 AWTP--VTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPER 10414

Query: 1727  PSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWL 1786
             P  ++  E+T  +V ++W  P++  G  E    V E  S + G  K   V          
Sbjct: 10415 PEDLEVKEVTKNTVTLTWNPPKYDGG-SEIINYVLE--SRLIGTEKFHKVTNDNLLSRKY 10471

Query: 1787  KVKDLAEGVTYRFRIRA 1803
              VK L EG TY +R+ A
Sbjct: 10472 TVKGLKEGDTYEYRVSA 10488



 Score =  190 bits (483), Expect = 1e-47
 Identities = 365/1536 (23%), Positives = 598/1536 (38%), Gaps = 180/1536 (11%)

Query: 448   QLPRFTPLESGSLLISPTHISDAGT-------YTCLATNSRGV--DEASADLVVWARTRI 498
             +LP    +++    I  TH    G        +  +A N+ GV  + + +   + AR  +
Sbjct: 16174 ELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEV 16233

Query: 499   TKPP-------QDQSVIKGTQASMV-CGVTHDPRVTIRYIWEKDGATLGTESHPRIR-LD 549
               P        +D  V+   ++  V   +   P  TI+  W K    L   +   I+  D
Sbjct: 16234 DPPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQ--WIKGDQELSNTARLEIKSTD 16291

Query: 550   RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAIN 609
                SL +      D G Y  +  +  G  S + +++V   P  PE PV  +S V      
Sbjct: 16292 FATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVV-ISGVTAEKCT 16350

Query: 610   LTWTKPF-DGNSPLIRYILEMSENNA-PWTVLLASVDPKATSVTVKGLVPARSYQFRLCA 667
             L W  P  DG S +I YI+E  E +   WTV+ A+V   +  VT   L+    Y FR+ A
Sbjct: 16351 LAWKPPLQDGGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTK--LLEGNEYTFRIMA 16408

Query: 668   VNDVGKGQFSKDTERVSL-PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGY 726
             VN  G G+  +    V+  P   P AP    + +  T  S+++ W+ P     + IL GY
Sbjct: 16409 VNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTV-TKDSMIVVWERPASDGGSEIL-GY 16466

Query: 727   IIRYCLAGLPVGYQFKNITDADVNNLLLE--DLIIWTNYEIEVAAYNSAGLGVYS--SKV 782
             ++         G ++       +  L L    LI   +YE  V+A N+AGL   S  S  
Sbjct: 16467 VLE---KRDKEGIRWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAY 16523

Query: 783   TEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGIN-QGYKLIAWEPEQEEEVT 841
              +         PP N        +++  +W+ P   +  G   QGY ++        E T
Sbjct: 16524 QKACDPIYKPGPPNNPKVIDITRSSVFLSWSKPI--YDGGCEIQGY-IVEKCDVSVGEWT 16580

Query: 842   MVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPV--- 898
             M T  P   +  ++     L+K  EY   +      G G          H DVPGP+   
Sbjct: 16581 MCTP-PTGINKTNIEVEKLLEKH-EYNFRICAINKAGVGE---------HADVPGPIIVE 16629

Query: 899   GHLSFSEI-LDTSLK--VSWQEPGEKNGI--LTGYRISWEEYNRTNTRVTHY-LPNVTLE 952
               L   +I LD  L+  ++ +  G       + G      ++ + +  +    + +VT  
Sbjct: 16630 EKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSS 16689

Query: 953   YRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQ 1012
             +    L  +  Y      +T +      ++ ++  V  + P PP NL ++ I   SV++ 
Sbjct: 16690 FTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTVRVL-DTPSPPVNLKVTEITKDSVSIT 16748

Query: 1013  FRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRM 1071
             + P   DG + I  ++VE +     E         ++N     S ++  L     Y FR+
Sbjct: 16749 WEPPLLDGGSKIKNYIVEKR-----EATRKSYAAVVTN-CHKNSWKIDQLQEGCSYYFRV 16802

Query: 1072  RQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPES 1131
                N  G   P+Q +  I+  + P    P  +++   +  S+ L W    + E++G  + 
Sbjct: 16803 TAENEYGIGLPAQTADPIKVAEVP--QPPGKITVDDVTRNSVSLSWT---KPEHDGGSKI 16857

Query: 1132  VGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTV 1190
             + Y ++      H +  S   + +      I +L +  EY  +V A N  G S P S  V
Sbjct: 16858 IQYIVEMQAK--HSEKWSECARVK-SLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAV 16914

Query: 1191  VGRTRESV--PSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQP 1248
                 ++ V  P   P   S        + +   EVP + R    + +         D  P
Sbjct: 16915 PIVAKDLVIEPDVKPAFSSYSVQVGQDLKI---EVPISGRPKPTITWT-------KDGLP 16964

Query: 1249  RFWLVEGNSSRSAQLTGL----------GKYVLYEVQVLAFTRIGDGSPSHPPILERTLD 1298
                    N + S  LT L          G+Y +    V     +G  + S    +E    
Sbjct: 16965 LKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANV-----VGQKTAS----IEIVTL 17015

Query: 1299  DVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSA 1357
             D P PP G + F +V   S+ L W PP    G  +   I  + +TTT  T    V A  A
Sbjct: 17016 DKPDPPKGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTT--TVWDVVSATVA 17073

Query: 1358  R-QYTATGLKPESVYLFRITAQTRKGWGEAAEA-LVVTTEKRDRPQPPSRPMVQQEDVRA 1415
             R     T LK  + Y FRI A+ R G   A E+  +V       P PP  P      +  
Sbjct: 17074 RTTLKVTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATA--ISK 17131

Query: 1416  RSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKF 1474
              S+++ W EP ++G SPV  Y ++ +E  S  W   + ++ H+ + F    L+    Y+F
Sbjct: 17132 DSMVIQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHD-TQFKAQNLEEGIEYEF 17190

Query: 1475  RVKATNDIGDSEFSEESESLTTLQAA-PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGI 1533
             RV A N +G  + S+ SE         P   P  + V  +  T   ++W  P  D    +
Sbjct: 17191 RVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEIT---LQWTKPVYDG-GSM 17246

Query: 1534  LLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHR 1593
             + G+ +  R+L               P   W +     S  N+     TQ+ +  L + +
Sbjct: 17247 ITGYIVEKRDL---------------PDGRWMKA----SFTNVIE---TQFTVSGLTEDQ 17284

Query: 1594  RYEIRMSVYNAVG--------EGPSSPPQEVFVGEAVPTAAPRNVVVHGATAT---QLDV 1642
             RYE R+   NA G         GP +   EV +         R+ +V  A  T   + DV
Sbjct: 17285 RYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADV 17344

Query: 1643  TWEP-PPLDSQNGDIQGYKIYFWEAQRGNLTER-VKTLFLAENSVKLKNLTGYTAYMVSV 1700
               +P P ++   GD +       E+ R  +     K L + ++++++            +
Sbjct: 17345 HGKPLPTIEWLRGDKE-----IEESARCEIKNTDFKALLIVKDAIRI------DGGQYIL 17393

Query: 1701  AAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLV 1760
              A N AG   +S P   +           V+ + +T+   +++W +P   +G  +    V
Sbjct: 17394 RASNVAGS--KSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTW-SPPLQDGGSDISHYV 17450

Query: 1761  YEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA-KTFTYGPEIE-ANVTT 1818
              E          +V  +V  NS   LKV  L EG  Y FRI A   +  G  +E A V  
Sbjct: 17451 VEKRETSRLAWTVVASEVVTNS---LKVTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLM 17507

Query: 1819  GPGEGAPGPP-GVPIIVRYSSAIAIHWSSGD-PGKGPITRYVIEARPSDEGLWDILIKDI 1876
                   PGPP  + +      ++ + W+  D  G   I  Y++E R      W   IK  
Sbjct: 17508 KNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRW---IKCN 17564

Query: 1877  PKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPS 1912
              + ++     +  L     Y+FRV A N  G G PS
Sbjct: 17565 KRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPS 17600



 Score =  190 bits (482), Expect = 1e-47
 Identities = 360/1569 (22%), Positives = 576/1569 (36%), Gaps = 242/1569 (15%)

Query: 412  TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
            TV  G  + L    +G P P ITW K + IL           P +S ++ I  +  SD G
Sbjct: 7396 TVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKS-TVTIVDSKRSDTG 7454

Query: 472  TYTCLATNSRGVDEASADLVVWAR---------TRITK--------PPQDQSVIKGTQAS 514
            TY   A N  G   A  ++ V  +         T +T         PP+D         S
Sbjct: 7455 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDG------GS 7508

Query: 515  MVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA 574
             +     + R T   +W K  +T+   +    +L  N               Y  RV + 
Sbjct: 7509 KITNYVVERRATDSEVWHKLSSTVKDTNFKATKLIPNKE-------------YIFRVAAE 7555

Query: 575  ---GGNDSRSAHLRVRQLPHAPEHPVATL--STVERRAINLTWTKPFD-GNSPLIRYILE 628
               G  +   A     +    P  P   L  S + + A+ LTW +P D G SP+  Y +E
Sbjct: 7556 NMYGVGEPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVE 7615

Query: 629  MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL--P 686
              + +    V    +  K T+  VKGL   + Y+FR+ A N  G G+ SK TE + +  P
Sbjct: 7616 RLDPDTDKWVRCNKMPVKDTTYRVKGLTNKKKYRFRVLAENLAGPGKPSKSTEPILIKDP 7675

Query: 687  EEPPTAPPQNVIAS-GRTNQSIMIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNI 744
             +PP  P +  +   G+T  S+ + W  P   H  G  ++ Y+I     G     +    
Sbjct: 7676 IDPPWPPGKPTVKDVGKT--SVRLNWTKP--EHDGGAKIESYVIEMLKTGTDEWVRVAE- 7730

Query: 745  TDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGNVHAEA 802
                    LL  L+    Y   V A N AG    S  S       +  P  PP  +    
Sbjct: 7731 -GVPTTQHLLPGLMEGQEYSFRVRAVNKAGESEPSEPSDPVLCREKLYPPSPPRWLEVIN 7789

Query: 803  TNSTTIRFTWNAPSPQFINGI------NQGYKLIAWEP-EQEEEVTMVTARPNFQDSIHV 855
                T    W  P     + I       +  +   W+  +   + T  T  P  + S++V
Sbjct: 7790 ITKNTADLKWTVPEKDGGSPITNYIVEKRDVRRKGWQTVDTTVKDTKCTVTPLTEGSLYV 7849

Query: 856  GFVS-----GLKKFTEYFTSVLC---FTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEIL 907
              V+     G   +TE   SVL    FTT                  PGP   L+  ++ 
Sbjct: 7850 FRVAAENAIGQSDYTEIEDSVLAKDTFTT------------------PGPPYALAVVDVT 7891

Query: 908  DTSLKVSWQEPGEKNG-ILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTI 966
               + + W+ P    G  +  Y I  +E   T              +RVT +   T    
Sbjct: 7892 KRHVDLKWEPPKNDGGRPIQRYVIEKKERLGTRWVKAGKTAGPDCNFRVTDVIEGTEVQF 7951

Query: 967  EVAAMTSKGQGQVSAST--ISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSI 1023
            +V A    G G  S  T  +S   P   P PP +L +++ G + + + ++ P  +G + I
Sbjct: 7952 QVRAENEAGVGHPSEPTEILSIEDPTSPPSPPLDLHVTDAGRKHIAIAWKPPEKNGGSPI 8011

Query: 1024 SRWLVE-AQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPP 1082
              + VE   VG     E+W+ ++    + D +      + P   Y  R+R VN +G S P
Sbjct: 8012 IGYHVEMCPVGT----EKWMRVNSRPIK-DLKFKVEEGVVPDKEYVLRVRAVNAIGVSEP 8066

Query: 1083 SQPSRKIQTLQAPPDMAPANVSLRTAS---------ETSLWLRWMPLPEMEYNGNPESVG 1133
            S+ S  +  +   PD  P  + L T              +  R +P+P + ++ + + V 
Sbjct: 8067 SEISENV--VAKDPDCKP-TIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVK 8123

Query: 1134 YKIKYSRSDGHGKTLSHV-VQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVG 1192
               + +  + H    +H+ V   V  D  I        Y + ++  N +GS   S  V  
Sbjct: 8124 ASDRLTMKNDH--ISAHLEVPKSVRADAGI--------YTITLE--NKLGSATASINV-- 8169

Query: 1193 RTRESVPSSGP-TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW 1251
               + +   GP  ++ A   T SS  + W E PE D    +L Y  + + +++  +    
Sbjct: 8170 ---KVIGLPGPCKDIKASDITKSSCKLTW-EPPEFDGGTPILHY--VLERREAGRRTYIP 8223

Query: 1252 LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGS--PSHPPILERTLDDVPGPPMGILF 1309
            ++ G +  S  +  L     Y  +V A  ++G G       P++ +     P PP+ +  
Sbjct: 8224 VMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEV 8283

Query: 1310 PEVRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPE 1368
                  ++ + W+PP    G  I+ Y I              E L P    YTA GL+  
Sbjct: 8284 HNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP-ILTYTAKGLEEG 8342

Query: 1369 SVYLFRITAQTRKGWGEAAEALVVT--TEKRDRPQPPSRPM--VQQEDVRARSVLLS--- 1421
              Y FR+ A+   G  E + A   T   +  D P+   R    V++ D  A    +S   
Sbjct: 8343 KEYQFRVRAENAAGISEPSRATPPTKAVDPIDAPKVILRTSLEVKRGDEIALDASISGSP 8402

Query: 1422 -----WEPGSDGLSPV------------RYYTIQTRE---LPSGRWALHSASVSHNASSF 1461
                 W    + + P             R   +Q  E   LP  +      S    +   
Sbjct: 8403 YPTITWIKDENVIVPEEIKKRAAPLVRRRKGEVQEEEPFVLPLTQRLSIDNSKKGESQLR 8462

Query: 1462 IVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPH-TTTSVLI 1520
            + D L+P     + +K  ND G       +++  T+       P I  V      TSVL 
Sbjct: 8463 VRDSLRPDHGL-YMIKVENDHG------IAKAPCTVSVLDTPGPPINFVFEDIRKTSVLC 8515

Query: 1521 RWQPPAEDKINGILLGFRIRYRELLYEGLRGFTL--RGINNPGATWAELTSMYSMRNLSR 1578
            +W+PP +D  + I+                 +TL  +    P + W  +TS  ++R+   
Sbjct: 8516 KWEPPLDDGGSEII----------------NYTLEKKDKTKPDSEWIVVTS--TLRH--- 8554

Query: 1579 PSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV-PTAAPRNVVVHGATA 1637
                +Y +  L + + Y  R+   N  G GP    + +   +   P  AP   +V   T+
Sbjct: 8555 ---CKYSVTKLIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDAPDKPIVEDVTS 8611

Query: 1638 TQLDVTWEPPPLDSQNGD-IQGYKIYFWEAQRGNLT--ERVKTLFLAENSVKLKNLTGYT 1694
              + V W  P     NG  I G   Y+ E +  N T   RV    L      +  L    
Sbjct: 8612 NSMLVKWNEP---KDNGSPILG---YWLEKREVNSTHWSRVNKSLLNALKANVDGLLEGL 8665

Query: 1695 AYMVSVAAFNAAGDGPRSTPTQGQT--QQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
             Y+  V A NAAG G  S P+  +T     +P  P   + ++ ++T++ + WE P F  G
Sbjct: 8666 TYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELEWEPPAFNGG 8725

Query: 1753 ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEI 1812
               G  + Y     + G ++      K        VK++ EG  Y+ R+ A         
Sbjct: 8726 ---GEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGADYKLRVSA--------- 8773

Query: 1813 EANVTTGPGEGAPG------------PPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE 1860
                    GEG PG            PP V + V     I I       GK      V+ 
Sbjct: 8774 ----VNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIM-----AGKTLRIPAVVT 8824

Query: 1861 ARPSDEGLW 1869
             RP    +W
Sbjct: 8825 GRPVPTKVW 8833



 Score =  189 bits (481), Expect = 2e-47
 Identities = 331/1484 (22%), Positives = 562/1484 (37%), Gaps = 198/1484 (13%)

Query: 416   GMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESG--SLLISPTHISDAGTY 473
             G S+ L     G P P + W K       G ++      + S   SL++   +  D+G Y
Sbjct: 16652 GGSLRLFVPIKGRPTPEVKWGK-----VDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKY 16706

Query: 474   TCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTI------ 527
             T    NS G   A   + V        PP +  V + T+ S+   +T +P +        
Sbjct: 16707 TLTLENSSGTKSAFVTVRV---LDTPSPPVNLKVTEITKDSV--SITWEPPLLDGGSKIK 16761

Query: 528   RYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAG----GNDSRSAH 583
              YI EK  AT  + +       +N S  I Q   G   +Y  RV +      G  +++A 
Sbjct: 16762 NYIVEKREATRKSYAAVVTNCHKN-SWKIDQLQEGC--SYYFRVTAENEYGIGLPAQTAD 16818

Query: 584   -LRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLA 641
              ++V ++P  P     T+  V R +++L+WTKP  DG S +I+YI+EM   ++      A
Sbjct: 16819 PIKVAEVPQPPGK--ITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECA 16876

Query: 642   SVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ--------FSKDTERVSLPEEPPTAP 693
              V  K+    +  L     Y FR+ AVN+ G+           +KD   V  P+  P   
Sbjct: 16877 RV--KSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDL--VIEPDVKPAFS 16932

Query: 694   PQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFK-NITDADVNNL 752
               +V         + I  +P P            I +   GLP+    + N+TD+    L
Sbjct: 16933 SYSVQVGQDLKIEVPISGRPKPT-----------ITWTKDGLPLKQTTRINVTDS----L 16977

Query: 753   LLEDLIIWTNYEIEVAAYNSAGLGVYSSKVT--EWTLQGVPTVPPGNVHAEATNSTTIRF 810
              L  L I   ++ +   Y      V   K    E      P  P G V  +  ++ +I  
Sbjct: 16978 DLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITL 17037

Query: 811   TWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTS 870
             +WN P          G ++  +  ++ +  T V    +   +     V+ LK  TEY   
Sbjct: 17038 SWNPPL------YTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFR 17091

Query: 871   VLCFTTPGDG--PRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTG 927
             +      G      S P + +     PGP G    + I   S+ + W EP    G  + G
Sbjct: 17092 IFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIG 17151

Query: 928   YRISWEEYN-----RTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAS 982
             Y +  +E N     + N  + H       +++   L     Y   V A    G G+ S +
Sbjct: 17152 YHLERKERNSILWTKVNKTIIH-----DTQFKAQNLEEGIEYEFRVYAENIVGVGKASKN 17206

Query: 983   T--ISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGE 1039
             +    +  P + PG P  + +       +TLQ+ +P YDG + I+ ++VE +    G   
Sbjct: 17207 SECYVARDPCDPPGTPEPIMVKR---NEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWM 17263

Query: 1040  EWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMA 1099
             +    + +  +       V  L     Y FR+   N  G    S+PS     + A  ++ 
Sbjct: 17264 KASFTNVIETQ-----FTVSGLTEDQRYEFRVIAKNAAGAI--SKPSDSTGPITAKDEVE 17316

Query: 1100  PANVSLR---------TASET---SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKT 1147
                +S+           A ET      +   PLP +E+    + +    +    +   K 
Sbjct: 17317 LPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKA 17376

Query: 1148  LSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVS 1207
             L  +V+D +  D            +  ++A N  GS  +   V    R   P  GP  V+
Sbjct: 17377 LL-IVKDAIRIDGG----------QYILRASNVAGSKSFPVNVKVLDRPG-PPEGPVQVT 17424

Query: 1208  ALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNS--SRSAQLTG 1265
              +  TS    + WS  P     G  + + V+ K    +T    W V  +   + S ++T 
Sbjct: 17425 GV--TSEKCSLTWS--PPLQDGGSDISHYVVEKR---ETSRLAWTVVASEVVTNSLKVTK 17477

Query: 1266  LGKYVLYEVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPP 1324
             L +   Y  +++A  + G G P    P+L +    +PGPP  +    +   S+ + W  P
Sbjct: 17478 LLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRP 17537

Query: 1325  AAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG 1384
              +  G  +   I  + + +            +  +   TGL  +  Y FR++A+   G G
Sbjct: 17538 DSDGGSEIIGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVG 17597

Query: 1385  EAAEALVV--TTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRE 1441
             E + A V     +   +P PP+   +   D    S+ L+W +P  DG S +  Y ++  +
Sbjct: 17598 EPSPATVYYKACDPVFKPGPPTNAHIV--DTTKNSITLAWGKPIYDGGSEILGYVVEICK 17655

Query: 1442  LPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501
                  W + +       + F + +L     YK RV A N +G  E +  S   T      
Sbjct: 17656 ADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEAT--SVPGTVKPEDK 17713

Query: 1502  DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
              EAP  L +       +++R    A   I                        +G   P 
Sbjct: 17714 LEAPE-LDLDSELRKGIVVRAGGSARIHI----------------------PFKGRPTPE 17750

Query: 1562  ATWAELTSMYS--MRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVG 1619
              TW+     ++  ++     + TQ  +DN +++   +  + + N+ G    S    V V 
Sbjct: 17751 ITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSG----SKSAFVTVK 17806

Query: 1620  EAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR---GNLTERVK 1676
                    P+N+ V         + WEPP +D     ++ Y I   E+ R    N++ +  
Sbjct: 17807 VLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDG-GAKVKNYVIDKRESTRKAYANVSSK-- 17863

Query: 1677  TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELT 1736
                 ++ S K++NLT    Y   V A N  G G              PS P  V  ++++
Sbjct: 17864 ---CSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVS 17920

Query: 1737  TTSVNVSWEAPQFPNGI-LEGYRLVYEPCS----PVDGVSKIVTVDVKGNSPLWLKVKDL 1791
              TS ++ WE P+   G  + GY +  +P       +   SK+    V G          L
Sbjct: 17921 QTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTG----------L 17970

Query: 1792  AEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
             + G  Y+FR++A    Y  +         G+  P   GVP+I +
Sbjct: 17971 SSGQEYQFRVKA----YNEK---------GKSDPRVLGVPVIAK 18001



 Score =  189 bits (479), Expect = 3e-47
 Identities = 429/1885 (22%), Positives = 716/1885 (37%), Gaps = 273/1885 (14%)

Query: 124  VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENT---LVILSTVAPDAGR 180
            V  GE   I  P   + P P V+W +DG+++  S R+ +  ++    L +  +V  DAG 
Sbjct: 8093 VIEGEKLSIPVP-FRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGI 8151

Query: 181  YYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVAN 240
            Y +   N K G    S  I + V  + GP   I        K + +   + ++T E    
Sbjct: 8152 YTITLEN-KLGSATAS--INVKVIGLPGPCKDI--------KASDITKSSCKLTWEPPEF 8200

Query: 241  ARPLIKLHIIWKKDGVLLSGGISDHNRRLTIPNPTGSDAGYYECEAVL-------RSSSV 293
                  LH + ++          +  RR  IP  +G +   +  + ++       R  +V
Sbjct: 8201 DGGTPILHYVLER---------REAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAV 8251

Query: 294  PSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW----YKDAAVV 349
              V  G Y+  L+ P   ++P++      +  VD+          +ITW    Y   + +
Sbjct: 8252 NKVGGGEYIE-LKNPVIAQDPKQ----PPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKI 8306

Query: 350  E---VEKLTRFRQR----NDGGLQI-----SGLVPDDTGMFQCFARNAAGEVQTSTYLAV 397
                +EK+ +  +R    N+  + I      GL       F+  A NAAG  + S     
Sbjct: 8307 MGYIIEKIAKGEERWKRCNEHLVPILTYTAKGLEEGKEYQFRVRAENAAGISEPSRATPP 8366

Query: 398  TSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLES 457
            T     I          D   V+L        R ++  ++G+ I    S+         S
Sbjct: 8367 TKAVDPI----------DAPKVIL--------RTSLEVKRGDEIALDASI---------S 8399

Query: 458  GSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVC 517
            GS   + T I D             + + +A LV   +  + +  ++  V+  TQ     
Sbjct: 8400 GSPYPTITWIKDENVIV-----PEEIKKRAAPLVRRRKGEVQE--EEPFVLPLTQ----- 8447

Query: 518  GVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGN 577
                  R++I      D +  G ES  R+R           +   D G Y  +V +  G 
Sbjct: 8448 ------RLSI------DNSKKG-ESQLRVR----------DSLRPDHGLYMIKVENDHGI 8484

Query: 578  DSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAP- 635
                  + V   P  P + V     + + ++   W  P D G S +I Y LE  +   P 
Sbjct: 8485 AKAPCTVSVLDTPGPPINFV--FEDIRKTSVLCKWEPPLDDGGSEIINYTLEKKDKTKPD 8542

Query: 636  --WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSL-PEEPPTA 692
              W V+ +++     SVT   L+  + Y FR+ A N  G G        V+  P  PP A
Sbjct: 8543 SEWIVVTSTLRHCKYSVTK--LIEGKEYLFRVRAENRFGPGPPCVSKPLVAKDPFGPPDA 8600

Query: 693  PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNL 752
            P + ++    +N S++++W  P +   NG     I+ Y L    V     +  +  + N 
Sbjct: 8601 PDKPIVEDVTSN-SMLVKWNEPKD---NG---SPILGYWLEKREVNSTHWSRVNKSLLNA 8653

Query: 753  L---LEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNV--HAEATNSTT 807
            L   ++ L+    Y   V A N+AG G +S      T    P  PPG        T+STT
Sbjct: 8654 LKANVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHD-PISPPGPPIPRVTDTSSTT 8712

Query: 808  IRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTAR-PNFQDSIHVGFVSGLKKFTE 866
            I   W  P+       N G +++ +  +++   T   +R       +    V  +++  +
Sbjct: 8713 IELEWEPPA------FNGGGEIVGYFVDKQLVGTNEWSRCTEKMIKVRQYTVKEIREGAD 8766

Query: 867  YFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKN---- 922
            Y   V      G+GP    Q V   E    P   L      D S+K   Q    K     
Sbjct: 8767 YKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVEL------DVSVKGGIQIMAGKTLRIP 8820

Query: 923  GILTGYRIS---W--EEYNRTNTRVTHYLPNVTLEYRVTGLTALTT-YTIEVAAMTSKGQ 976
             ++TG  +    W  EE      RV   + NV  +  +    AL   +   V   T+   
Sbjct: 8821 AVVTGRPVPTKVWTKEEGELDKDRVV--IDNVGTKSELIIKDALRKDHGRYVITATNSCG 8878

Query: 977  GQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVV 1035
             + +A+ +      ++PGP  +L       +   L +  P  DG + I+ +++E +   +
Sbjct: 8879 SKFAAARVEVF---DVPGPVLDLKPVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKM 8935

Query: 1036 GEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAP 1095
                + +       E +    ++  L     Y FR+   N  G  PP +    +      
Sbjct: 8936 HTWRQPI-------ETERSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLG 8988

Query: 1096 PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDR 1155
            P  +P  ++    +++++ L W    E   NG     GY I+  R   H K     V  R
Sbjct: 8989 PPTSPERLTYTERTKSTITLDWK---EPRSNGGSPIQGYIIEKRR---HDKPDFERVNKR 9042

Query: 1156 V--ERDYTIEDLEEWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESVPSSGPTNVSALATT 1212
            +     + +E+L+E   Y  +V+A N IG S P     V    + VP   PT    L+  
Sbjct: 9043 LCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVP---PTIKLRLSVR 9099

Query: 1213 SSSMLVRWSE---VPEADRNGLVLGYKVMYKEKDSDTQPR--FWLVEGNSSRSAQLTGLG 1267
              ++ V+  E   +P AD  GL +      K +    +P     + +   SRS   T L 
Sbjct: 9100 GDTIKVKAGEPVHIP-ADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELS 9158

Query: 1268 --KYVLYE---VQVLAFTRIGDGSPS-HPPILERTLDDVPGPPMGILFPEVRTTSVRLIW 1321
              K V  +     V A  R+G    + H  + +R     P PP  +   +++  S  L W
Sbjct: 9159 IPKAVREDKGTYTVTASNRLGSVFRNVHVEVYDR-----PSPPRNLAVTDIKAESCYLTW 9213

Query: 1322 QPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSA-RQYTATGLKPESVYLFRITAQTR 1380
              P    G  + + +  + + +       EV   +  ++Y    L P   Y FR+ A  +
Sbjct: 9214 DAPLDNGGSEITHYVIDKRDASRKKAEWEEVTNTAVEKRYGIWKLIPNGQYEFRVRAVNK 9273

Query: 1381 KGWGEAAEA-LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSD-GLSPVRYYTIQ 1438
             G  +  ++  VV  +    P PP +P V        S+L+SW P  D G SP+  Y ++
Sbjct: 9274 YGISDECKSDKVVIQDPYRLPGPPGKPKVLART--KGSMLVSWTPPLDNGGSPITGYWLE 9331

Query: 1439 TRELPSGRWALHSAS----VSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESE-S 1493
             RE  S  W+  S +    V      F V RL     Y+FR  A N  G    SE S+  
Sbjct: 9332 KREEGSPYWSRVSRAPITKVGLKGVEFNVPRLLEGVKYQFRAMAINAAGIGPPSEPSDPE 9391

Query: 1494 LTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFT 1553
            +      P   P+   V   T +S+ + W+PPA+D  + I  G+ +  +E   EG   + 
Sbjct: 9392 VAGDPIFPPGPPSCPEVKDKTKSSISLGWKPPAKDGGSPIK-GYIVEMQE---EGTTDW- 9446

Query: 1554 LRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-PSSP 1612
             + +N P         +               + NL + R+Y  R+   N  GE  PS  
Sbjct: 9447 -KRVNEPDKLITTCECV---------------VPNLKELRKYRFRVKAVNEAGESEPSDT 9490

Query: 1613 PQEVFVGEA-------VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWE 1665
              E+   +        +   A   +V    +  ++    +  P    + +  G      +
Sbjct: 9491 TGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRPTPKSSWEFDGKAKKAMK 9550

Query: 1666 AQRGNLTERVKTLFLAENSVKL------KNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQT 1719
                ++ E  + L  AENS  +      ++ TG      S+ A N AG   + T      
Sbjct: 9551 DGVHDIPEDAQ-LETAENSSVIIIPECKRSHTG----KYSITAKNKAG---QKTANCRVK 9602

Query: 1720 QQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDV 1778
                P  P  +K S++T  S  +SW+ P    G  ++GY +       +DG +       
Sbjct: 9603 VMDVPGPPKDLKVSDITRGSCRLSWKMPDDDGGDRIKGYVIEKRT---IDGKAWTKVNPD 9659

Query: 1779 KGNSPLWLKVKDLAEGVTYRFRIRAKT-FTYGPEIEA-NVTTGPGEGAPGPPGVPIIVRY 1836
             G++     V DL     Y FR+RA+  F  GP +E    TT      P  P + + +  
Sbjct: 9660 CGSTTF--VVPDLLSEQQYFFRVRAENRFGIGPPVETIQRTTARDPIYPPDPPIKLKIGL 9717

Query: 1837 SSAIAIHWSSGDP---GKGPITRYVIEARPSD-----EGLWDILIKDIPKEVSSYTFSMD 1888
             +   +H S   P   G  P+T Y++E    D     +  W    K   ++V    F+++
Sbjct: 9718 ITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNK---RDVEELQFTVE 9774

Query: 1889 ILKPGVSYDFRVIAVNDYGFGTPSS 1913
             L  G  Y+FRV AVN  G   PS+
Sbjct: 9775 DLVEGGEYEFRVKAVNAAGVSKPSA 9799



 Score =  187 bits (474), Expect = 1e-46
 Identities = 315/1447 (21%), Positives = 553/1447 (38%), Gaps = 151/1447 (10%)

Query: 524   RVTIRYIWEKDGATLGTESHPRIRLDRNGSL-HISQTWSGDIGTYTCRVISAGGNDSRSA 582
             R T    W KD   L   +        N SL  I      D+G Y  ++ ++ G    + 
Sbjct: 15869 RPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETL 15928

Query: 583   HLRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAP-WTVLL 640
             ++ V   P  P  PV  +  V   +I L+W  P +DG S +  YI+E  + +   W ++ 
Sbjct: 15929 NVIVLDKPGPPTGPVK-MDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVS 15987

Query: 641   ASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIAS 700
             A+V    T++    L     YQFR+ A N  GK  +      V+        PP   + +
Sbjct: 15988 ATV--ARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPVVT 16045

Query: 701   GRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIW 760
               +  S+ +QW  P     + ++  ++ R       + +   N T           L   
Sbjct: 16046 LSSRDSMEVQWNEPISDGGSRVIGYHLERK--ERNSILWVKLNKTPIPQTKFKTTGLEEG 16103

Query: 761   TNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFI 820
               YE  V+A N  G+G   SKV+E  +   P  PPG   A      ++   W  P+    
Sbjct: 16104 VEYEFRVSAENIVGIGK-PSKVSECYVARDPCDPPGRPEAIIVTRNSVTLQWKKPT---- 16158

Query: 821   NGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPG- 878
                + G K+  +  E++E       + +F + I   F V+GL +   Y   V+     G 
Sbjct: 16159 --YDGGSKITGYIVEKKELPEGRWMKASFTNIIDTHFEVTGLVEDHRYEFRVIARNAAGV 16216

Query: 879   -DGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNR 937
                P  +   +   ++V  P   +S       ++ V   E  + +  + G  I   ++ +
Sbjct: 16217 FSEPSESTGAITARDEVDPP--RISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIK 16274

Query: 938   TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL----- 992
              +  +++     T    +      T+ +++ A     G   + A  ++      +     
Sbjct: 16275 GDQELSN-----TARLEIKSTDFATSLSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVL 16329

Query: 993   --PGPPTN-LGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQVGVVGEGEEWLLIHQLS 1048
               PGPP   + IS +     TL ++P   DG + I  ++VE +          L+   + 
Sbjct: 16330 DRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSDIINYIVERRE------TSRLVWTVVD 16383

Query: 1049  NEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTA 1108
                   S +V  L     Y+FR+  VN  G   P +    +         AP    + T 
Sbjct: 16384 ANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTV 16443

Query: 1109  SETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV--ERDYTIEDLE 1166
             ++ S+ + W        +G  E +GY ++    +G   T  H    R+  E    +  L 
Sbjct: 16444 TKDSMIVVW---ERPASDGGSEILGYVLEKRDKEGIRWTRCH---KRLIGELRLRVTGLI 16497

Query: 1167  EWTEYRVQVQAFNAIG-SGPWSQTVVGRTRESVPSSGP-TNVSALATTSSSMLVRWSEVP 1224
             E  +Y  +V A NA G S P   +   +  + +   GP  N   +  T SS+ + WS+ P
Sbjct: 16498 ENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNPKVIDITRSSVFLSWSK-P 16556

Query: 1225  EADRNGLVLGYKVMYKEKDSDTQPRFWLV----EGNSSRSAQLTGLGKYVLYEVQVLAFT 1280
               D    + GY V    +  D     W +     G +  + ++  L +   Y  ++ A  
Sbjct: 16557 IYDGGCEIQGYIV----EKCDVSVGEWTMCTPPTGINKTNIEVEKLLEKHEYNFRICAIN 16612

Query: 1281  RIGDGSPSHPP---ILERTLDDVPGPPMGILFPEVRTT----SVRLIWQPPAAPNGIILA 1333
             + G G  +  P   I+E  L+  P   + +   ++       S+RL       P   +  
Sbjct: 16613 KAGVGEHADVPGPIIVEEKLE-APDIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKW 16671

Query: 1334  YQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVY---LFRITAQTRKGWGEAAEAL 1390
              ++   +     + A ++V +     +T+  L   + Y    + +T +   G     ++ 
Sbjct: 16672 GKVDGEIR----DAAIIDVTS----SFTSLVLDNVNRYDSGKYTLTLENSSG----TKSA 16719

Query: 1391  VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSGRWAL 1449
              VT    D P PP    V +  +   SV ++WEP   DG S ++ Y ++ RE     +A 
Sbjct: 16720 FVTVRVLDTPSPPVNLKVTE--ITKDSVSITWEPPLLDGGSKIKNYIVEKREATRKSYAA 16777

Query: 1450  HSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILS 1509
                +   N  S+ +D+L+   SY FRV A N+ G    ++ ++ +   +    + P  ++
Sbjct: 16778 VVTNCHKN--SWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVP--QPPGKIT 16833

Query: 1510  VTPHTTTSVLIRWQPPAED---KINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAE 1566
             V   T  SV + W  P  D   KI   ++  + ++ E                    W+E
Sbjct: 16834 VDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSE-------------------KWSE 16874

Query: 1567  LTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEG-------PSSPPQEVFVG 1619
                + S+         Q  + NL +   Y  R+   N  G         P      V   
Sbjct: 16875 CARVKSL---------QAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIEP 16925

Query: 1620  EAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLF 1679
             +  P  +  +V V      ++ ++  P P  +   D    K    +  R N+T+   +L 
Sbjct: 16926 DVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLK----QTTRINVTD---SLD 16978

Query: 1680  LAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTS 1739
             L   S+K  +      Y ++VA  N  G    S       +   P  P  VKF +++  S
Sbjct: 16979 LTTLSIKETHKDDGGQYGITVA--NVVGQKTASIEIVTLDKPDPPKGP--VKFDDVSAES 17034

Query: 1740  VNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRF 1799
             + +SW  P +  G  +    + +       V  +V+  V   +   LKV  L  G  Y+F
Sbjct: 17035 ITLSWNPPLYTGGC-QITNYIVQKRDTTTTVWDVVSATVARTT---LKVTKLKTGTEYQF 17090

Query: 1800  RIRAKTF---TYGPEIEANVTTGPGEGAPGPPGVPIIVRYSS-AIAIHWSSG-DPGKGPI 1854
             RI A+     ++  E +  V   P +  PGPPG P     S  ++ I W    + G  P+
Sbjct: 17091 RIFAENRYGQSFALESDPIVAQYPYK-EPGPPGTPFATAISKDSMVIQWHEPVNNGGSPV 17149

Query: 1855  TRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSP 1914
               Y +E +  +  LW  + K I   +    F    L+ G+ Y+FRV A N  G G  S  
Sbjct: 17150 IGYHLERKERNSILWTKVNKTI---IHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKN 17206

Query: 1915  SQSVPAQ 1921
             S+   A+
Sbjct: 17207 SECYVAR 17213



 Score =  177 bits (449), Expect = 1e-43
 Identities = 352/1605 (21%), Positives = 600/1605 (37%), Gaps = 162/1605 (10%)

Query: 367   ISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGP-------LDSTVI--DGM 417
             +SGL  D    F+  A+NAAG +   +  +      +    P          TVI   G 
Sbjct: 15113 VSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVILKAGE 15172

Query: 418   SVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
             +  L  + SG P P + W K  + L  G+ +L       S +L+   +   D+G YT  A
Sbjct: 15173 AFRLEADVSGRPPPTMEWSKDGKEL-EGTAKLEIKIADFSTNLVNKDSTRRDSGAYTLTA 15231

Query: 478   TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDP-------RVTIRYI 530
             TN  G  +   ++ V  R     PP+    +     S  C ++  P       ++    +
Sbjct: 15232 TNPGGFAKHIFNVKVLDRPG---PPEGPLAVTEV-TSEKCVLSWFPPLDDGGAKIDHYIV 15287

Query: 531   WEKDGATLG-TESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA---GGNDSRSAHLRV 586
              +++ + L  T     +++ +   L +++   G+   Y  RV++    G  +   +   +
Sbjct: 15288 QKRETSRLAWTNVASEVQVTK---LKVTKLLKGN--EYIFRVMAVNKYGVGEPLESEPVL 15342

Query: 587   RQLPHAPEHPVAT--LSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASV 643
                P+ P  P     ++T+ + ++ + W  P  DG S +I YI+E  +      +     
Sbjct: 15343 AVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIKCNKK 15402

Query: 644   DPKATSVTVKGLVPARSYQFRLCAVNDVG------KGQFSKDTERVSLPEEPPTAPPQNV 697
                     V GL     Y+FR+ A N  G         F K  + V  P      PP N 
Sbjct: 15403 TLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVFKP-----GPPGNP 15457

Query: 698   IASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDA---DVNNLLL 754
                  +  SI I W  P     + I  GY++   L   P   +++ +T        +  +
Sbjct: 15458 RVLDTSRSSISIAWNKPIYDGGSEIT-GYMVEIAL---PEEDEWQIVTPPAGLKATSYTI 15513

Query: 755   EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNA 814
               L     Y+I + A NS GLG     +   T +    + P  +  +A     +      
Sbjct: 15514 TGLTENQEYKIRIYAMNSEGLG--EPALVPGTPKAEDRMLPPEIELDADLRKVVTIRACC 15571

Query: 815   PSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFT--EYFTSVL 872
                 F+    +    + W  +  E +   +       ++ +  V  + +F   +Y  +V 
Sbjct: 15572 TLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLI--VGNVNRFDSGKYILTV- 15628

Query: 873   CFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRIS 931
                    G +S    VR   D PGP   L   E+  TS+ ++W  P    G  +  Y + 
Sbjct: 15629 ---ENSSGSKSAFVNVRVL-DTPGPPQDLKVKEVTKTSVTLTWDPPLLDGGSKIKNYIVE 15684

Query: 932   WEEYNR-------TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 984
               E  R       TN   T         ++V  L    +Y   V A    G G + A T 
Sbjct: 15685 KRESTRKAYSTVATNCHKT--------SWKVDQLQEGCSYYFRVLAENEYGIG-LPAETA 15735

Query: 985   SSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLL 1043
              S    E P PP  + + ++   SV+L + +P +DG + I  ++VE Q       ++W  
Sbjct: 15736 ESVKASERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQ---TKGSDKWAT 15792

Query: 1044  IHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPA 1101
                +          +  L     YSFR+   N  G S P Q S  +  + L  PP     
Sbjct: 15793 CATVK----VTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIPPAFKLL 15848

Query: 1102  NVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERD-- 1159
               +    +   L +      ++ + G P      + + + +   K  + V  +  E +  
Sbjct: 15849 FNTFTVLAGEDLKV------DVPFIGRPTPA---VTWHKDNVPLKQTTRVNAESTENNSL 15899

Query: 1160  YTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVR 1219
              TI+D          V+  N+ G    +  V+   +   P +GP  +  +  T+ S+ + 
Sbjct: 15900 LTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPG-PPTGPVKMDEV--TADSITLS 15956

Query: 1220  WSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA-QLTGLGKYVLYEVQVLA 1278
             W   P+ D    +  Y V   EK   +   + +V    +R+  +   L     Y+ ++ A
Sbjct: 15957 WGP-PKYDGGSSINNYIV---EKRDTSTTTWQIVSATVARTTIKACRLKTGCEYQFRIAA 16012

Query: 1279  FTRIGDGS--PSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQ 1335
               R G  +   S P + +     VPGPP   +       S+ + W  P +  G  ++ Y 
Sbjct: 16013 ENRYGKSTYLNSEPTVAQYPF-KVPGPPGTPVVTLSSRDSMEVQWNEPISDGGSRVIGYH 16071

Query: 1336  ITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTE 1395
             +  +   +       +   P  + +  TGL+    Y FR++A+   G G+ ++       
Sbjct: 16072 LERKERNSILWVKLNKTPIPQTK-FKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYV- 16129

Query: 1396  KRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASV 1454
              RD   PP RP  +   V   SV L W +P  DG S +  Y ++ +ELP GRW + ++  
Sbjct: 16130 ARDPCDPPGRP--EAIIVTRNSVTLQWKKPTYDGGSKITGYIVEKKELPEGRW-MKASFT 16186

Query: 1455  SHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHT 1514
             +   + F V  L     Y+FRV A N  G   FSE SES   + A  +  P  +S+ P  
Sbjct: 16187 NIIDTHFEVTGLVEDHRYEFRVIARNAAG--VFSEPSESTGAITARDEVDPPRISMDPKY 16244

Query: 1515  TTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRG-FTLRGINNPGATWAELTSMYSM 1573
               ++++        K++  + G  I       + ++G   L           +  +  S+
Sbjct: 16245 KDTIVV--HAGESFKVDADIYGKPIP----TIQWIKGDQELSNTARLEIKSTDFATSLSV 16298

Query: 1574  RNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVH 1633
             ++  R     Y L   N      + ++V      GP   P                VV+ 
Sbjct: 16299 KDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGP----------------VVIS 16342

Query: 1634  GATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGY 1693
             G TA +  + W+ PPL     DI  Y +   E  R  L   V    +   S K+  L   
Sbjct: 16343 GVTAEKCTLAWK-PPLQDGGSDIINYIVERRETSR--LVWTVVDANVQTLSCKVTKLLEG 16399

Query: 1694  TAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPN 1751
               Y   + A N  G G    S P   +     P AP + + + +T  S+ V WE P    
Sbjct: 16400 NEYTFRIMAVNKYGVGEPLESEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDG 16459

Query: 1752  GI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFT--- 1807
             G  + GY L       +    +      +    L L+V  L E   Y FR+ A+      
Sbjct: 16460 GSEILGYVLEKRDKEGI----RWTRCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLS 16515

Query: 1808  -YGPEIEANVTTGPGEGAPGPPGVPIIVRYS-SAIAIHWSSG-DPGKGPITRYVIEARPS 1864
                P         P    PGPP  P ++  + S++ + WS     G   I  Y++E    
Sbjct: 16516 EPSPPSAYQKACDP-IYKPGPPNNPKVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDV 16574

Query: 1865  DEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFG 1909
               G W +     P  ++     ++ L     Y+FR+ A+N  G G
Sbjct: 16575 SVGEWTMCTP--PTGINKTNIEVEKLLEKHEYNFRICAINKAGVG 16617



 Score =  177 bits (449), Expect = 1e-43
 Identities = 292/1333 (21%), Positives = 502/1333 (37%), Gaps = 167/1333 (12%)

Query: 647   ATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGR-TNQ 705
             +T++  K      S  + L A N    G F+K    V + + P   PP+  +A    T++
Sbjct: 15211 STNLVNKDSTRRDSGAYTLTATNP---GGFAKHIFNVKVLDRP--GPPEGPLAVTEVTSE 15265

Query: 706   SIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNI-TDADVNNLLLEDLIIWTNYE 764
               ++ W PP +      +  YI++           + N+ ++  V  L +  L+    Y 
Sbjct: 15266 KCVLSWFPPLDDG-GAKIDHYIVQKRETSR---LAWTNVASEVQVTKLKVTKLLKGNEYI 15321

Query: 765   IEVAAYNSAGLG--VYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFING 822
               V A N  G+G  + S  V      G P  PP N         ++   W  P       
Sbjct: 15322 FRVMAVNKYGVGEPLESEPVLAVNPYGPPD-PPKNPEVTTITKDSMVVCWGHPDS----- 15375

Query: 823   INQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPG-DG 880
              + G ++I +  E+ ++      + N +    + + VSGL +  EY   ++     G   
Sbjct: 15376 -DGGSEIINYIVERRDKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISA 15434

Query: 881   PRSTPQLVRTHEDV--PGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYNR 937
             P  T    +  + V  PGP G+    +   +S+ ++W +P    G  +TGY +       
Sbjct: 15435 PSPTSPFYKACDTVFKPGPPGNPRVLDTSRSSISIAWNKPIYDGGSEITGYMVEIALPEE 15494

Query: 938   TNTRVTHYLPNVTLE---YRVTGLTALTTYTIEVAAMTSKGQGQVSA-----STISSGVP 989
                ++    P   L+   Y +TGLT    Y I + AM S+G G+ +            +P
Sbjct: 15495 DEWQIV--TPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAEDRMLP 15552

Query: 990   PELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSN 1049
             PE+        +  I        F P         +W  +      GE  +   I   S+
Sbjct: 15553 PEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDH-----GESLDKASIESTSS 15607

Query: 1050  EPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTAS 1109
                   + V ++N F    + +   N  G+       R + T   P D+      ++  +
Sbjct: 15608 YT---LLIVGNVNRFDSGKYILTVENSSGSKSAFVNVRVLDTPGPPQDL-----KVKEVT 15659

Query: 1110  ETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWT 1169
             +TS+ L W P P ++  G  +   Y ++  + +   K  S V  +  +  + ++ L+E  
Sbjct: 15660 KTSVTLTWDP-PLLD--GGSKIKNYIVE--KRESTRKAYSTVATNCHKTSWKVDQLQEGC 15714

Query: 1170  EYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSG----PTNVSALATTSSSMLVRWSEVPE 1225
              Y  +V A N  G G     +   T ESV +S     P  ++ +  T +S+ + W E PE
Sbjct: 15715 SYYFRVLAENEYGIG-----LPAETAESVKASERPLPPGKITLMDVTRNSVSLSW-EKPE 15768

Query: 1226  ADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDG 1285
              D    +LGY V  + K SD       V+      A +TGL +   Y  +V A    G  
Sbjct: 15769 HDGGSRILGYIVEMQTKGSDKWATCATVKVTE---ATITGLIQGEEYSFRVSAQNEKGIS 15825

Query: 1286  SPSH------------PP---ILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI 1330
              P              PP   +L  T   + G  + +  P +   +  + W     P   
Sbjct: 15826 DPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVP--- 15882

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL 1390
                 + T R+N  +    ++  +  + R+           Y+ ++T       GEA E L
Sbjct: 15883 ---LKQTTRVNAESTENNSLLTIKDACREDVGH-------YVVKLTNSA----GEAIETL 15928

Query: 1391  VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGS-DGLSPVRYYTIQTRELPSGRWAL 1449
              V     D+P PP+ P V+ ++V A S+ LSW P   DG S +  Y ++ R+  +  W +
Sbjct: 15929 NVIV--LDKPGPPTGP-VKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQI 15985

Query: 1450  HSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILS 1509
              SA+V+   ++    RLK    Y+FR+ A N  G S +     ++          P    
Sbjct: 15986 VSATVAR--TTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGTPV 16043

Query: 1510  VTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTS 1569
             VT  +  S+ ++W  P  D  + ++                G+ L         W +L  
Sbjct: 16044 VTLSSRDSMEVQWNEPISDGGSRVI----------------GYHLERKERNSILWVKL-- 16085

Query: 1570  MYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGE--AVPTAAP 1627
                  N +    T+++   L +   YE R+S  N VG G  S   E +V      P   P
Sbjct: 16086 -----NKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRP 16140

Query: 1628  RNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKL 1687
               ++V   T   + + W+ P  D     I GY +   E   G   +   T  + +   ++
Sbjct: 16141 EAIIV---TRNSVTLQWKKPTYDG-GSKITGYIVEKKELPEGRWMKASFTNII-DTHFEV 16195

Query: 1688  KNLTGYTAYMVSVAAFNAAGDGPRSTPTQG----QTQQAAPSAPSSVKFSELTTTSVNVS 1743
               L     Y   V A NAAG     + + G    + +   P      K+ +        S
Sbjct: 16196 TGLVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGES 16255

Query: 1744  WEAPQFPNGILEGYRLVYEPCSPVDGV------SKIVTVDVKGNS-PLWLKVKDLAEGVT 1796
             ++      G         +P   +  +      S    +++K       L VKD     +
Sbjct: 16256 FKVDADIYG---------KPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDS 16306

Query: 1797  YRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSA--IAIHWSSG-DPGKGP 1853
               + ++AK       +  NV        PGPP  P+++   +A    + W      G   
Sbjct: 16307 GNYILKAKNVAGERSVTVNVKV---LDRPGPPEGPVVISGVTAEKCTLAWKPPLQDGGSD 16363

Query: 1854  ITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSS 1913
             I  Y++E R +   +W +    +   V + +  +  L  G  Y FR++AVN YG G    
Sbjct: 16364 IINYIVERRETSRLVWTV----VDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVG---E 16416

Query: 1914  PSQSVPAQKANPF 1926
             P +S P    NPF
Sbjct: 16417 PLESEPVVAKNPF 16429



 Score =  171 bits (433), Expect = 7e-42
 Identities = 352/1639 (21%), Positives = 604/1639 (36%), Gaps = 203/1639 (12%)

Query: 366   QISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPL--------DSTVIDGM 417
             +++ L  D    F+ FARNAA  V   +      I  +    P         D  V+   
Sbjct: 19440 EVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAG 19499

Query: 418   SVV-LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCL 476
              V+ +  + +G P P I+W K + I      +    +      L +      D G Y   
Sbjct: 19500 EVLKINADIAGRPLPVISWAK-DGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLT 19558

Query: 477   ATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGA 536
               N  G    + +  V  +     PP     I G  A   C ++          W +   
Sbjct: 19559 LKNVAGTRSVAVNCKVLDKPG---PPAGPLEINGLTAEK-CSLS----------WGRPQE 19604

Query: 537   TLGTESHPRIRLDRNGSLHISQT-WSGDIGTYTCRVIS-----------------AGGND 578
               G +    I +++  + H++ T   G++   +C+V                     G  
Sbjct: 19605 DGGADIDYYI-VEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEP 19663

Query: 579   SRSAHLRVRQLPHAPEHPVAT-LSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPW 636
               S  ++       P  P +  +++V + ++ L W++P  DG S +  YI+E  E N+  
Sbjct: 19664 LESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLR 19723

Query: 637   TVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT------ERVSLPEEPP 690
              V +         V   GL     Y++R+ A N  G    S+ +      + V LP  PP
Sbjct: 19724 WVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPS-PP 19782

Query: 691   TAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVN 750
             + P   ++ SG+T  +I I W  P        + GY + Y           K   D D  
Sbjct: 19783 SKP--KIVDSGKT--TITIAWVKPLFDG-GAPITGYTVEY-----------KKSDDTDWK 19826

Query: 751   NLL---------LEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAE 801
               +         +  L     Y   V + N  G    S        +     P  ++ +E
Sbjct: 19827 TSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSE 19886

Query: 802   ATNSTTIR----FTWNAPS-----PQFI-NGINQGYKLIAWEPEQEEEVTMVTARPNFQD 851
                +  ++    FT   P      P  + +  +   +  A+    +   ++     N  D
Sbjct: 19887 MRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRND 19946

Query: 852   SIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSL 911
             S          K+T    +VL          ++  LV    D PGP  +++  ++   S 
Sbjct: 19947 S---------GKYTLTIQNVLS--------AASLTLVVKVLDTPGPPTNITVQDVTKESA 19989

Query: 912   KVSWQEPGEKNGI-LTGYRISWEEYNRTN-TRVTHYLPNVTLEYRVTGLTALTTYTIEVA 969
              +SW  P    G  +  Y I   E ++     VT+      L Y+VT L     Y   V+
Sbjct: 19990 VLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNR--LSYKVTNLQEGAIYYFRVS 20047

Query: 970   AMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLV 1028
                  G G + A T       E P PP  LG+++I   SV+L + +P +DG + I  ++V
Sbjct: 20048 GENEFGVG-IPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVV 20106

Query: 1029  EAQVGVVGEGEE-WLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSR 1087
             EA    + +G++ W+      +        V  L   + Y FR+   N  G S P +   
Sbjct: 20107 EA----LEKGQKNWVKCAVAKSTHHV----VSGLRENSEYFFRVFAENQAGLSDPRE--- 20155

Query: 1088  KIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY--NGNPESVGYKIKYSRSDGHG 1145
              +  +     + P  + ++     ++++R     +++   +G P     K+  SR     
Sbjct: 20156 LLLPVLIKEQLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLP---KVTLSRDGVPL 20212

Query: 1146  KTLSHVVQDRVERDYTIEDLEEWTEY--RVQVQAFNAIGSGPWSQTVVGRTRESVPSSGP 1203
             K       +    + TI   E  T    R ++ A N+ G+      +V   R   P +GP
Sbjct: 20213 KATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPG-PPTGP 20271

Query: 1204  TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQL 1263
               +S +  T  S+ ++W E P+ D    V  Y ++ +E  +            +      
Sbjct: 20272 VVISDI--TEESVTLKW-EPPKYDGGSQVTNYILLKRETSTAVWTEVSATVARTMMKVMK 20328

Query: 1264  TGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLD-DVPGPPMGILFPEVRTTSVRLIWQ 1322
                G+   Y+ ++ A  R G         +   L    PGPP       V   S+ + W 
Sbjct: 20329 LTTGEE--YQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWH 20386

Query: 1323  PPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382
              P +  G  +        +  +        L      +  T +    +Y FR+ A+   G
Sbjct: 20387 EPVSNGGSAVVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAG 20446

Query: 1383  WGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRE 1441
              G+ +          D  +PP    V+  D+   SV LSW+ P  DG S +  Y ++ R+
Sbjct: 20447 VGKPSHPSEPVLAI-DACEPPRN--VRITDISKNSVSLSWQQPAFDGGSKITGYIVERRD 20503

Query: 1442  LPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAP 1501
             LP GRW   S + +   + FI+  L   + Y+FRV A N +G    S  SE +  +    
Sbjct: 20504 LPDGRWTKASFT-NVTETQFIISGLTQNSQYEFRVFARNAVGS--ISNPSEVVGPITCID 20560

Query: 1502  DEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPG 1561
                  ++ + P   T V                    ++YR      LR   + G   P 
Sbjct: 20561 SYGGPVIDL-PLEYTEV--------------------VKYRAGTSVKLRA-GISGKPAPT 20598

Query: 1562  ATW------AELTSMYSMRNLSR-PSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQ 1614
               W       +  ++  + N +   S+   + D LN    YE+++   NA+G   ++   
Sbjct: 20599 IEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGC-YELKLR--NAMGSASATIRV 20655

Query: 1615  EVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTER 1674
             ++ + +  P   P  +     TA ++ + W PP  D       G KI  +  ++   +  
Sbjct: 20656 QI-LDKPGPPGGP--IEFKTVTAEKITLLWRPPADDG------GAKITHYIVEKRETSRV 20706

Query: 1675  VKTLF---LAENSVKLKNLTGYTAYMVSVAAFNAAGDGP--RSTPTQGQTQQAAPSAPSS 1729
             V ++    L E  +    +     Y+  V A N  G G    S     +     P  P  
Sbjct: 20707 VWSMVSEHLEECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI 20766

Query: 1730  VKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKV 1788
              + +++T  S+ V W  P    G  + GY L       + G  K++   ++       KV
Sbjct: 20767 PEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSL-GWFKVLKETIRDTRQ---KV 20822

Query: 1789  KDLAEGVTYRFRIRAKTFT-YGPEIEANVTTGPGEGAPGPPGVPIIVRYS----SAIAIH 1843
               L E   Y++R+ A      GP  E +      +    PPG P  +R +    S+I + 
Sbjct: 20823 TGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPID-PPGPPAKIRIADSTKSSITLG 20881

Query: 1844  WSSGD-PGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIA 1902
             WS     G   +T YV+E R  +E  W  +      EV +  + +  LKPGV+Y FRV A
Sbjct: 20882 WSKPVYDGGSAVTGYVVEIRQGEEEEWTTV--STKGEVRTTEYVVSNLKPGVNYYFRVSA 20939

Query: 1903  VNDYGFGTPSSPSQSVPAQ 1921
             VN  G G P   ++ V A+
Sbjct: 20940 VNCAGQGEPIEMNEPVQAK 20958



 Score =  167 bits (423), Expect = 1e-40
 Identities = 305/1309 (23%), Positives = 495/1309 (37%), Gaps = 158/1309 (12%)

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLAS 642
             +++ + P  PE    T  ++ + +++LTW KP  DG S ++ Y++E  E      V  A 
Sbjct: 20064 VKITEKPSPPEKLGVT--SISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAV 20121

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPE--EPPTAPPQN---- 696
                K+T   V GL     Y FR+ A N  G     +    V + E  EPP    +N    
Sbjct: 20122 A--KSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSH 20179

Query: 697   ---VIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLL 753
                V A       I I  +P P+           +     G+P+    +  T+    NL 
Sbjct: 20180 TVYVRAGSNLKVDIPISGKPLPK-----------VTLSRDGVPLKATMRFNTEITAENLT 20228

Query: 754   --LEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 811
               L++ +       E+ A NS+G       +      G PT P   V        ++   
Sbjct: 20229 INLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGP---VVISDITEESVTLK 20285

Query: 812   WNAPSPQFINGINQGYKLIAWEPEQEE----EVTMVTARPNFQDSIHVGFVSGLKKFTEY 867
             W  P     +G +Q    I  + E       EV+   AR   +       V  L    EY
Sbjct: 20286 WEPPK---YDGGSQVTNYILLKRETSTAVWTEVSATVARTMMK-------VMKLTTGEEY 20335

Query: 868   FTSVLCFTTPG--DGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG-I 924
                +      G  D   S    V+     PGP      + +   S+ V W EP    G  
Sbjct: 20336 QFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVTRESITVGWHEPVSNGGSA 20395

Query: 925   LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTI 984
             + GY +  ++ N    +  + L   T  ++VT ++A   Y   V A  + G G+ S  + 
Sbjct: 20396 VVGYHLEMKDRNSILWQKANKLVIRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPS- 20454

Query: 985   SSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLL 1043
                +  +   PP N+ I++I   SV+L ++ P +DG + I+ ++VE +    G   +   
Sbjct: 20455 EPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTK--- 20511

Query: 1044  IHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGT-SPPSQ---PSRKIQTLQAPPDMA 1099
                 +N  + + + +  L   + Y FR+   N VG+ S PS+   P   I +   P    
Sbjct: 20512 -ASFTNVTETQFI-ISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDL 20569

Query: 1100  PANVS--LRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVE 1157
             P   +  ++  + TS+ LR         +G P      I++ + D   +T + V  +   
Sbjct: 20570 PLEYTEVVKYRAGTSVKLR------AGISGKPAPT---IEWYKDDKELQTNALVCVENTT 20620

Query: 1158  --RDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV-VGRTRESVPSSGPTNVSALATTSS 1214
                   I+D +       +++  NA+GS   S T+ V    +  P  GP     +     
Sbjct: 20621 DLASILIKDADRLNSGCYELKLRNAMGSA--SATIRVQILDKPGPPGGPIEFKTVTAEKI 20678

Query: 1215  SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTG--LGKYVLY 1272
             ++L R    P AD  G  + + ++ K + S      W +         +T   + K   Y
Sbjct: 20679 TLLWR----PPADDGGAKITHYIVEKRETSRV---VWSMVSEHLEECIITTTKIIKGNEY 20731

Query: 1273  EVQVLAFTRIGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI- 1330
               +V A  + G G P     ++ +     PGPP      ++   S+ ++W  P A  G  
Sbjct: 20732 IFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSD 20791

Query: 1331  ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEA- 1389
             I  Y +  R   +      ++      RQ   TGL   S Y +R+ A    G G  +E  
Sbjct: 20792 ISGYFLEKRDKKSLGWFKVLKETIRDTRQ-KVTGLTENSDYQYRVCAVNAAGQGPFSEPS 20850

Query: 1390  -LVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRW 1447
                   +  D P PP++  ++  D    S+ L W +P  DG S V  Y ++ R+     W
Sbjct: 20851 EFYKAADPIDPPGPPAK--IRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEW 20908

Query: 1448  ALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI 1507
                S       + ++V  LKP  +Y FRV A N  G  E  E +E +        EAP I
Sbjct: 20909 TTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDIL--EAPEI 20966

Query: 1508  LSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAE- 1566
               +     TSV+ +     ED    +L+ F                 +G   P  TW + 
Sbjct: 20967 -DLDVALRTSVIAK---AGEDV--QVLIPF-----------------KGRPPPTVTWRKD 21003

Query: 1567  -----LTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEA 1621
                    + YS+ N    SL        N   +Y   +++ N VGE P S    V V + 
Sbjct: 21004 EKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY--ILTIENGVGE-PKSSTVSVKVLD- 21059

Query: 1622  VPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLF-- 1679
              P A  +  V H +  T + + W+PP +D       G  I  +  ++ + T+R  ++   
Sbjct: 21060 TPAACQKLQVKHVSRGT-VTLLWDPPLIDG------GSPIINYVIEKRDATKRTWSVVSH 21112

Query: 1680  -LAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
               +  S KL +L+  T +   V A N  G G     T+       P+    +   + T T
Sbjct: 21113 KCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVPAPIRDLSMKDSTKT 21172

Query: 1739  SVNVSWEAPQFPNGILEGYRLVY-----EPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAE 1793
             SV +SW  P F  G +    +V      E      G+SK   ++          V  L E
Sbjct: 21173 SVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIE----------VSQLKE 21222

Query: 1794  GVTYRFRIRAKT-------FTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
                  FR+ AK         T GP     +   P       PG  + VR
Sbjct: 21223 QSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVR 21271



 Score =  164 bits (414), Expect = 1e-39
 Identities = 332/1511 (21%), Positives = 556/1511 (36%), Gaps = 169/1511 (11%)

Query: 473   YTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRY--- 529
             +   A N +G+ +      +  +  I  P  D S I G Q ++  G  H+  + + Y   
Sbjct: 21228 FRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRIG--HNVHLELPYKGK 21285

Query: 530   -----IWEKDGATLGTESHPRIRLDRNG-SLHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
                   W KDG  L      R     N  +L I        G YT  + +A    +    
Sbjct: 21286 PKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRIAVPIT 21345

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAP-WTVLLA 641
             +     P  P+ P+     ++  ++ L+W  P D G   +  Y +E  E +   W ++ +
Sbjct: 21346 VITLGPPSKPKGPIR-FDEIKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCS 21404

Query: 642   SVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASG 701
             SV    T+  V  LV    YQFR+ A N  G  Q    +  V+  +     PP   +   
Sbjct: 21405 SV--ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGPPGKPVIYN 21462

Query: 702   RTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWT 761
              T+  + + W  P     + +   ++ +       + +Q  N +           L+   
Sbjct: 21463 VTSDGMSLTWDAPVYDGGSEVTGFHVEKK--ERNSILWQKVNTSPISGREYRATGLVEGL 21520

Query: 762   NYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFIN 821
             +Y+  V A NSAGL   S   +++TL   P  PPG          TI   WN P      
Sbjct: 21521 DYQFRVYAENSAGLSSPSDP-SKFTLAVSPVDPPGTPDYIDVTRETITLKWNPPLR---- 21575

Query: 822   GINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPG-- 878
               + G K++ +  E+ +       R NF D     + V+GL     Y   ++     G  
Sbjct: 21576 --DGGSKIVGYSIEKRQGNER-WVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTI 21632

Query: 879   DGPRSTPQLVRTHEDVPGPV---GHLSFSEIL---DTSLKVSWQEPGEKNGILTGYRISW 932
               P  +  ++ T ++   P+   G   F  ++     SL++     G     +T ++   
Sbjct: 21633 SPPSQSSGIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGV 21692

Query: 933   EEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPEL 992
             E   R N  +T  L + +L  R         YT+E  A  + G  +          P ++
Sbjct: 21693 EIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVE--AKNASGSAKAEIKVKVQDTPGKV 21750

Query: 993   PGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEP 1051
              GP   +  +NI    +TL +  P  DG   I+ +++E +         W LI    ++ 
Sbjct: 21751 VGP---IRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRET---SRLAWALIE---DKC 21801

Query: 1052  DARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASET 1111
             +A+S     L     Y FR+  VN  G   P      +  +Q     AP        +  
Sbjct: 21802 EAQSYTAIKLINGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGN 21861

Query: 1112  SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV--ERDYTIEDLEEWT 1169
             S+ L W      E +G  E   Y ++  R +        V+  R   E  + +  L E  
Sbjct: 21862 SITLTWA---RPESDGGSEIQQYILE--RREKKSTRWVKVISKRPISETRFKVTGLTEGN 21916

Query: 1170  EYRVQVQAFNAIGSGPWSQ-TVVGRTRESV-PSSGPTNVSALATTSSSMLVRWSEVPEAD 1227
             EY   V A NA G GP S  + + + RE V P   PT V    T+ +++ + WS+ P  D
Sbjct: 21917 EYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSK-PVFD 21975

Query: 1228  RNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSP 1287
                 ++GY +   + D     +    E        +T L     Y+ +V A    G G  
Sbjct: 21976 GGMEIIGYIIEMCKADLGDWHKV-NAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDS 22034

Query: 1288  SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQ-------ITHRL 1340
                    + +D +  P + I     +T  VR       A   + +AYQ       +  + 
Sbjct: 22035 CEVTGTIKAVDRLTAPELDIDANFKQTHVVRA-----GASIRLFIAYQGRPTPTAVWSKP 22089

Query: 1341  NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRP 1400
             ++  +  A +     S    T           + +T +   G    ++++  T +  D P
Sbjct: 22090 DSNLSLRADIHT-TDSFSTLTVENCNRNDAGKYTLTVENNSG----SKSITFTVKVLDTP 22144

Query: 1401  QPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNAS 1459
              PP    +  +DV   S  L W+ P  DG + + +Y ++ RE     W + S   +    
Sbjct: 22145 GPPGP--ITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEKCTRQI- 22201

Query: 1460  SFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLT-TLQAAPDEAPTILSVTPHTTTSV 1518
              F V+ L     Y FRV A N+ G  E  E  E +  T Q AP   P  L V   + +S 
Sbjct: 22202 -FKVNDLAEGVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAP---PRRLDVVDTSKSSA 22257

Query: 1519  LIRWQPPAED---KINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRN 1575
             ++ W  P  D   +I G LL  R +  +   E   G T            +LT       
Sbjct: 22258 VLAWLKPDHDGGSRITGYLLEMRQKGSDFWVEA--GHT-----------KQLT------- 22297

Query: 1576  LSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV------PTA---- 1625
                     + ++ L +   YE R+   N  G    S P+E F    +      PTA    
Sbjct: 22298 --------FTVERLVEKTEYEFRVKAKNDAGY---SEPREAFSSVIIKEPQIEPTADLTG 22346

Query: 1626  -APRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTE-RVKTLFLAEN 1683
                + +     +   +DV     P       ++  ++   E  R ++T  + +T    ++
Sbjct: 22347 ITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLK--ETDRVSITTTKDRTTLTVKD 22404

Query: 1684  SVK---------LKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSE 1734
             S++         L+N  G   + V+V      G      P  G  + ++ SA S V    
Sbjct: 22405 SMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPG------PVTGPIEVSSVSAESCV---- 22454

Query: 1735  LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEG 1794
                    +SW  P+   G  E    + E         ++V   VK      +KV  L + 
Sbjct: 22455 -------LSWGEPKDGGGT-EITNYIVEKRESGTTAWQLVNSSVKRTQ---IKVTHLTKY 22503

Query: 1795  VTYRFRIRAKT-FTYGPEIE-ANVTTGPGEGAPGPPGVPIIVRYSS-AIAIHWSSG-DPG 1850
             + Y FR+ ++  F     +E A +        P  P  P +   S+ A++I W      G
Sbjct: 22504 MEYSFRVSSENRFGVSKPLESAPIIAEHPFVPPSAPTRPEVYHVSANAMSIRWEEPYHDG 22563

Query: 1851  KGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGT 1910
                I  Y +E +  +  LW   +K+         + +  L  G+ Y FR  A+N  G   
Sbjct: 22564 GSKIIGYWVEKKERNTILW---VKENKVPCLECNYKVTGLVEGLEYQFRTYALNAAGVSK 22620

Query: 1911  PSSPSQSVPAQ 1921
              S  S+ + AQ
Sbjct: 22621 ASEASRPIMAQ 22631



 Score =  161 bits (408), Expect = 6e-39
 Identities = 283/1169 (24%), Positives = 437/1169 (37%), Gaps = 141/1169 (12%)

Query: 412   TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLI-SPTHISDA 470
             T+  G S+ L    SG P P ITW K    LAS ++        ES SLLI    +  DA
Sbjct: 23152 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAI----IDTTESYSLLIVDKVNRYDA 23207

Query: 471   GTYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRV----- 525
             G YT  A N  G   A+  + V+     T  P     +K      V      P +     
Sbjct: 23208 GKYTIEAENQSGKKSATVLVKVYD----TPGPCPSVKVKEVSRDSVTITWEIPTIDGGAP 23263

Query: 526   TIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVI-----SAGGNDSR 580
                YI EK  A +        +  +     IS    G +  Y  RV+       G     
Sbjct: 23264 VNNYIVEKREAAMRAFKTVTTKCSKT-LYRISGLVEGTM--YYFRVLPENIYGIGEPCET 23320

Query: 581   SAHLRVRQLPHAPEHPVATLSTVE--RRAINLTWTKP-FDGNSPLIRYILEMSENNAPWT 637
             S  + V ++P  P    A L  V+  +  + L W KP +DG S L  Y+LE  +      
Sbjct: 23321 SDAVLVSEVPLVP----AKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERW 23376

Query: 638   VLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVS------LPEEPPT 691
             + + ++ P     TV  L     Y FR+ A N+ G  +  +    V+      LP    +
Sbjct: 23377 MKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLS 23436

Query: 692   APPQNVI--ASGRTNQSIM-IQWQPPPESHQNGILKGYIIRYCLAG--LPVGYQFKNITD 746
               PQ  I   +GR  + ++ I  +PPP +            +  AG  L    +    T 
Sbjct: 23437 TMPQKTIHVPAGRPVELVIPIAGRPPPAAS-----------WFFAGSKLRESERVTVETH 23485

Query: 747   ADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNST 806
               V  L + +  I    E  +   N  G    + KV      G PT P   +  +  ++T
Sbjct: 23486 TKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGP---IKIDEIDAT 23542

Query: 807   TIRFTWNAPSPQFINGINQGYKLIAWEPEQEEE-------VTMVTARPNFQDSIHVGFVS 859
             +I  +W  P       ++ G  L  +  EQ +        V+    R  F+        +
Sbjct: 23543 SITISWEPPE------LDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFK-------FT 23589

Query: 860   GLKKFTEYFTSVLCFTTPGDGPRSTPQLV--RTHEDVPGPVGHLSFSEILDTSLKVSWQE 917
              L +  EY   V      G G     +++  R+   +PGP   L   ++    + ++W  
Sbjct: 23590 RLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMTLTWYP 23649

Query: 918   PGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQ 976
             P +  G  +TGY +  +E         + +P     YR TGLT    Y   V A+ ++G 
Sbjct: 23650 PEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGS 23709

Query: 977   GQVS--ASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVG 1033
             G+ S  +  I +  P   PG P N  +++    SV+L +  P  +G + ++ +L+E Q  
Sbjct: 23710 GKPSRPSKPIVAMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKV 23769

Query: 1034  VVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQP--SRKIQT 1091
                +  EW   +    +   R   +  L     Y FR+   N  G   P++   + K+  
Sbjct: 23770 ---DQHEWTKCNTTPTK--IREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTE 23824

Query: 1092  LQAPPDMA-----PANVSLRTASETSLWL--RWMPLPEMEYNGNPESVGYKIKYSRSDGH 1144
             +   PD          + +R      L +  +  P P  ++    + +  +   + S+ H
Sbjct: 23825 MLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETH 23884

Query: 1145  GKTLSHVVQDRVERDYTIEDL--EEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSS- 1201
              +    V+++    D    DL  E     +        IGS               P+S 
Sbjct: 23885 TEL---VIKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGS---------------PNSP 23926

Query: 1202  -GPTNVSALATTSSSMLVRWSEVPEADRNGL-VLGYKVMYKEKDSDTQPRFWLVEGNSSR 1259
              GP     +   S    VR S  P AD  G  +LGY +  +E         W    +  R
Sbjct: 23927 EGPLEYDDIQVRS----VRVSWRPPADDGGADILGYILERREVPKAA----WYTIDSRVR 23978

Query: 1260  SAQLT--GLGKYVLYEVQVLAFTRIGDGSP--SHPPILERTLDDVPGPPMGILFPEV--- 1312
                L   GL + V Y  +V A  + G   P  S  P+  +T  + P PP     PEV   
Sbjct: 23979 GTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNP--PEVLDV 24036

Query: 1313  RTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYL 1372
               +SV L W  P    G  +      R  T+T           +   YT TGL P++ Y 
Sbjct: 24037 TKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLVPDAEYQ 24096

Query: 1373  FRITAQTRKGWGEAAEAL--VVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGL 1429
             FRI AQ   G  E + A   VV  +  D+P  P    ++   +   SV L WE P  DG 
Sbjct: 24097 FRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGE--LEILSISKDSVTLQWEKPECDGG 24154

Query: 1430  SPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE 1489
               +  Y ++ R+     W   S         F +  L   T Y+FRV A N+ G S    
Sbjct: 24155 KEILGYWVEYRQSGDSAWK-KSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRR 24213

Query: 1490  ESESLTTLQAAPDEAPTILSVTPHTTTSV 1518
              + S+ T +    EAP I       TT +
Sbjct: 24214 TAMSIKT-KLTSGEAPGIRKEMKDVTTKL 24241



 Score =  158 bits (400), Expect = 5e-38
 Identities = 355/1546 (22%), Positives = 567/1546 (36%), Gaps = 189/1546 (12%)

Query: 334   GVPPPSITWYKDAAVVEVEKLTRFRQRND-GGLQISGLVPDDTGMFQCFARNAAGEVQTS 392
             G P P+I WYKD   ++   L       D   + I      ++G ++   RNA G    +
Sbjct: 20593 GKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASAT 20652

Query: 393   TYLAVTSIAPNITRGPLDSTVIDGMSVVL----ACETSGAPRPAITWQKGERILASGSVQ 448
               + +    P    GP++   +    + L      +  GA       +K E      S+ 
Sbjct: 20653 IRVQILD-KPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRETSRVVWSMV 20711

Query: 449   LPRFTPLESGSLLISPTHISDAGTY--TCLATNSRGVDE-ASADLVVWARTRITK-PPQD 504
                         +I+ T I     Y     A N  G+ E   +D VV     +T  PP  
Sbjct: 20712 SEHLE-----ECIITTTKIIKGNEYIFRVRAVNKYGIGEPLESDSVVAKNAFVTPGPPGI 20766

Query: 505   QSVIKGTQASMVCGVTH-----DPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQT 559
               V K T+ SM    +         ++  ++ ++D  +LG     +  +          T
Sbjct: 20767 PEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQKVTGLT 20826

Query: 560   WSGDIGTYTCRVISAG-GNDSRSAHLRVRQLPHAPEHPVATLSTVE--RRAINLTWTKP- 615
              + D     C V +AG G  S  +       P  P  P A +   +  + +I L W+KP 
Sbjct: 20827 ENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKIRIADSTKSSITLGWSKPV 20886

Query: 616   FDGNSPLIRYILEMSE-NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKG 674
             +DG S +  Y++E+ +     WT +    + + T   V  L P  +Y FR+ AVN  G+G
Sbjct: 20887 YDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTEYVVSNLKPGVNYYFRVSAVNCAGQG 20946

Query: 675   QFSKDTERVSLPE--EPP-----TAPPQNVIASGRTNQSIMIQW--QPPPESHQNGILKG 725
             +  +  E V   +  E P      A   +VIA    +  ++I +  +PPP        K 
Sbjct: 20947 EPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKN 21006

Query: 726   YIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEW 785
                     G    Y  +N    D ++LL    +   +    +    + G+G   S     
Sbjct: 21007 -------LGSDARYSIEN---TDSSSLLTIPQVTRNDTGKYILTIEN-GVGEPKSSTVSV 21055

Query: 786   TLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTA 845
              +   P      +  +  +  T+   W+ P       I+ G  +I +  E+ +      +
Sbjct: 21056 KVLDTPAACQ-KLQVKHVSRGTVTLLWDPPL------IDGGSPIINYVIEKRDATKRTWS 21108

Query: 846   RPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFS 904
               + + S     +  L + T +F  VL     G G P  T + V+  E VP P+  LS  
Sbjct: 21109 VVSHKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAE-VPAPIRDLSMK 21167

Query: 905   EILDTSLKVSWQEPGEKNG-ILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTT 963
             +   TS+ +SW +P    G ++T Y +  E   +     +H   + T E  V+ L   + 
Sbjct: 21168 DSTKTSVILSWTKPDFDGGSVITEYVV--ERKGKGEQTWSHAGISKTCEIEVSQLKEQSV 21225

Query: 964   YTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPG------Y 1017
                 V A   KG       TI      EL   P  + +S+I    VT++          Y
Sbjct: 21226 LEFRVFAKNEKGLS--DPVTIGPITVKELIITP-EVDLSDIPGAQVTVRIGHNVHLELPY 21282

Query: 1018  DGKTSIS-RW------LVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFR 1070
              GK   S  W      L E++     + E  + +   + + +        L+   C    
Sbjct: 21283 KGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVILDNAVCRI-- 21340

Query: 1071  MRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPE 1130
                + ++   PPS+P   I+  +   D              S+ L W  +P  E NG  E
Sbjct: 21341 AVPITVITLGPPSKPKGPIRFDEIKAD--------------SVILSW-DVP--EDNGGGE 21383

Query: 1131  SVGYKI-KYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG-SGPW-S 1187
                Y I K   S  + K +   V       + + +L +  EY+ +V+A N  G S P  S
Sbjct: 21384 ITCYSIEKRETSQTNWKMVCSSV---ARTTFKVPNLVKDAEYQFRVRAENRYGVSQPLVS 21440

Query: 1188  QTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDS--- 1244
               +V + +  +P   P        TS  M + W + P  D    V G+ V  KE++S   
Sbjct: 21441 SIIVAKHQFRIPGP-PGKPVIYNVTSDGMSLTW-DAPVYDGGSEVTGFHVEKKERNSILW 21498

Query: 1245  ---DTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLD--D 1299
                +T P        S R  + TGL + + Y+ +V A    G  SPS P      +   D
Sbjct: 21499 QKVNTSP-------ISGREYRATGLVEGLDYQFRVYAENSAGLSSPSDPSKFTLAVSPVD 21551

Query: 1300  VPGPPMGILFPEVRTTSVRLIWQPPAAPNGI-ILAYQITHRL-NTTTANTATVEVLAPSA 1357
              PG P  I   +V   ++ L W PP    G  I+ Y I  R  N         +V   S 
Sbjct: 21552 PPGTPDYI---DVTRETITLKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDV---SE 21605

Query: 1358  RQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARS 1417
              QYT TGL P   Y FRI A+   G              RD   P   P+V+        
Sbjct: 21606 CQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP---PIVEFGPEYFDG 21662

Query: 1418  VLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSY----- 1472
             +++       G S      +Q R +P   W      +    +  I D L   + +     
Sbjct: 21663 LII-----KSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDAT 21717

Query: 1473  -----KFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAE 1527
                   + V+A N  G    S ++E    +Q  P +    +  T  T   + + W  P  
Sbjct: 21718 RDHRGVYTVEAKNASG----SAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLN 21773

Query: 1528  DKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELD 1587
             D    I   + I  RE                    WA +            S T  +L 
Sbjct: 21774 DGCAPI-THYIIEKRE---------------TSRLAWALIED-----KCEAQSYTAIKLI 21812

Query: 1588  NLNKHRRYEIRMSVYNAVGEGP--SSPPQEVFVGEAVPTA----APRNVVVHGATATQLD 1641
             N N+   Y+ R+S  N  G G    S P    +   VP A     P N+     T   + 
Sbjct: 21813 NGNE---YQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNI-----TGNSIT 21864

Query: 1642  VTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVA 1701
             +TW  P  D    +IQ Y +   E +     + +    ++E   K+  LT    Y   V 
Sbjct: 21865 LTWARPESDG-GSEIQQYILERREKKSTRWVKVISKRPISETRFKVTGLTEGNEYEFHVM 21923

Query: 1702  AFNAAGDGPRSTPT---QGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGY 1757
             A NAAG GP S  +   + +     P  P+ VK ++ + T+V++ W  P F  G+ + GY
Sbjct: 21924 AENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGY 21983

Query: 1758  RLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRA 1803
               + E C     +     V+ +        V DL  G  Y+FR+ A
Sbjct: 21984 --IIEMCKA--DLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSA 22025



 Score =  158 bits (399), Expect = 6e-38
 Identities = 319/1434 (22%), Positives = 534/1434 (37%), Gaps = 160/1434 (11%)

Query: 531   WEKDGATLGTESHPRIRLD-RNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQL 589
             W KD A +  +    I+      +L   +    D G Y   V ++ G+      + V   
Sbjct: 10547 WFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDR 10606

Query: 590   PHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLASVDPKAT 648
             P  P  PV+    V +  + ++W  P D G S +  YI+E  E      + + S   K T
Sbjct: 10607 PGPPVGPVS-FDEVTKDYMVISWKPPLDDGGSKITNYIIEKKEVGKDVWMPVTSASAK-T 10664

Query: 649   SVTVKGLVPARSYQFRLCAVNDVG-KGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSI 707
             +  V  L+  + Y FR+ A N  G       D+ +       P AP Q ++    T  S 
Sbjct: 10665 TCKVSKLLEGKDYIFRIHAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEV-TKDSA 10723

Query: 708   MIQWQPPPESHQNGI-LKGYIIRYCLAGLPVGYQFKNITDADVN---NLLLEDLIIWTNY 763
             ++ W  P   H  G  +  YI+        +  ++  +T   ++      + DL+    Y
Sbjct: 10724 LVTWNKP---HDGGKPITNYILE---KRETMSKRWARVTKDPIHPYTKFRVPDLLEGCQY 10777

Query: 764   EIEVAAYNSAGLGVYS--SKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFIN 821
             E  V+A N  G+G  S  SK            PP N  A  T   ++  TW  P     +
Sbjct: 10778 EFRVSAENEIGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGS 10837

Query: 822   GINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDG- 880
              I  GY ++ ++   +EE       P          V+GL+    Y   VL     G+  
Sbjct: 10838 KI-LGY-IVEYQKVGDEEWRRANHTPESCPETKYK-VTGLRDGQTYKFRVLAVNAAGESD 10894

Query: 881   PRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGY---RISWEEYNR 937
             P   P+ V   + +  P   L  +   +  +KV   +    + I+ G    +++W++ +R
Sbjct: 10895 PAHVPEPVLVKDRLEPPELILDANMAREQHIKVG--DTLRLSAIIKGVPFPKVTWKKEDR 10952

Query: 938   ---TNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGV-PPELP 993
                T  R+        LE R         Y++ V       +    + T+S  V   + P
Sbjct: 10953 DAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTV-------ENPAGSKTVSVKVLVLDKP 11005

Query: 994   GPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPD 1052
             GPP +L +S I   S  L ++ P  DG + I+ ++VE +        +W     LS    
Sbjct: 11006 GPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVA---SAQW---SPLSATSK 11059

Query: 1053  ARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQ-APPDMAPANVSLRTASET 1111
              +S     LN    Y FR+   N  G  P  +  + I+ L    P   P ++      +T
Sbjct: 11060 KKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKT 11119

Query: 1112  SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHG----KTLSHVVQDRVERDYTIEDLEE 1167
              + L W    + + +G     GY ++Y           KT++++       +  +  L++
Sbjct: 11120 EVSLVW---NKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNL-------ECVVTGLQQ 11169

Query: 1168  WTEYRVQVQAFNAIGSGPWSQTVVGRTRES-VPSSGPTNVSAL--------ATTSSSMLV 1218
                YR +V+A N +G G    T+    +E  VP S   +V  +         T     ++
Sbjct: 11170 GKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAII 11229

Query: 1219  RWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLA 1278
             R   VP A         K      +  T   + +   N S    +    +    E Q+  
Sbjct: 11230 RGVPVPTA---------KWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQI-- 11278

Query: 1279  FTRIGDGSPSHPPILERTLDDVPGPPMG-ILFPEVRTTSVRLIWQPPAAPNGIILAYQIT 1337
                + + + S    +  T+ DVPGPP G I   +V    + + WQPP    G  +   I 
Sbjct: 11279 --TVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIV 11336

Query: 1338  HRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEAL-VVTTEK 1396
              +   T  +T  V     S  +     L+    Y+FR+ A+ + G G   ++   V   K
Sbjct: 11337 EK-QDTRKDTWGVVSSGSSKTKLKIPHLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHK 11395

Query: 1397  RDRPQPPSRPMVQQEDVRARSVLLSWE-PGSDGLSPVRYYTIQTRELPSGRWALHSASVS 1455
                P PP +P+V   D+   +  +SW  P SDG SP+  Y ++ RE+ +G+W   + +  
Sbjct: 11396 FSPPSPPGKPVV--TDITENAATVSWTLPKSDGGSPITGYYMERREV-TGKWVRVNKTPI 11452

Query: 1456  HNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTI-LSVTPHT 1514
              +   F V  L    +Y+FRV A N  G S+ S  S+ +   +      P I   +   +
Sbjct: 11453 ADL-KFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKS 11511

Query: 1515  TTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMR 1574
               +  + W  P  D  + IL                G+ +       A W  +     +R
Sbjct: 11512 RETADLVWTKPLSDGGSPIL----------------GYVVECQKPGTAQWNRINKDELIR 11555

Query: 1575  NLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV--PTAAPRNVVV 1632
               +      + +  L +   Y  R+   N VGEG      E  + + +  P     +V  
Sbjct: 11556 QCA------FRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTC 11609

Query: 1633  HGATATQLDVTW----------EPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAE 1682
                   ++  T           EP    ++ G +           R    + ++ L   E
Sbjct: 11610 RDVITVRVGQTIRILARVKGRPEPDITWTKEGKV---------LVREKRVDLIQDLPRVE 11660

Query: 1683  NSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNV 1742
               +K      +  Y++S  A N++G    S       +   P    ++K + +T  +  +
Sbjct: 11661 LQIKEAVRADHGKYIIS--AKNSSGHAQGSAIVNVLDR---PGPCQNLKVTNVTKENCTI 11715

Query: 1743  SWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIR 1802
             SWE P   NG  E    + E   P      IV  DV   +   +K   LA    Y FR+ 
Sbjct: 11716 SWENP-LDNGGSEITNFIVEYRKPNQKGWSIVASDV---TKRLIKANLLANN-EYYFRVC 11770

Query: 1803  AKT-FTYGPEIEA-------NVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGD-PGKGP 1853
             A+     GP IE        N    PGE    P  + I  +  + + + W   D  G  P
Sbjct: 11771 AENKVGVGPTIETKTPILAINPIDRPGE----PENLHIADKGKTFVYLKWRRPDYDGGSP 11826

Query: 1854  ITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG 1907
                Y +E R      W+ + K   KE     + +D       Y+FRV   N+ G
Sbjct: 11827 NLSYHVERRLKGSDDWERVHKGSIKETH---YMVDRCVENQIYEFRVQTKNEGG 11877



 Score =  158 bits (399), Expect = 6e-38
 Identities = 293/1278 (22%), Positives = 490/1278 (38%), Gaps = 155/1278 (12%)

Query: 302   LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITW-YKDAAVVEVEKLTRFRQR 360
             L VL        P++ I     + V++     G PPP+ +W +  + + E E++T     
Sbjct: 23427 LRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHT 23486

Query: 361   NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
                 L I      DTG +    +N  G   + T   +    P    GP+    ID  S+ 
Sbjct: 23487 KVAKLTIRETTIRDTGEYTLELKNVTG-TTSETIKVIILDKPGPPTGPIKIDEIDATSIT 23545

Query: 421   LACE----TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISP---THISDAGTY 473
             ++ E      GAP           ++       P + P+ S S+  S    T +++   Y
Sbjct: 23546 ISWEPPELDGGAPLSGY-------VVEQRDAHRPGWLPV-SESVTRSTFKFTRLTEGNEY 23597

Query: 474   T--CLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIW 531
                  ATN  G+       V+  R+ I  P   +++        +  V+ D      Y  
Sbjct: 23598 VFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETL-------QIFDVSRDGMTLTWYPP 23650

Query: 532   EKDGATLGT---ESHPRIRLD---RNGSLHISQTWSGDIG-----TYTCRVIS----AGG 576
             E DG +  T        +R D   R   + ++ T     G      Y  RV +      G
Sbjct: 23651 EDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGSG 23710

Query: 577   NDSRSAHLRVRQLPHA----PEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSE 631
               SR +   V   P A    P++P  T +T  R +++L W+ P D G S +  Y++EM +
Sbjct: 23711 KPSRPSKPIVAMDPIAPPGKPQNPRVTDTT--RTSVSLAWSVPEDEGGSKVTGYLIEMQK 23768

Query: 632   NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFS------KDTERVSL 685
              +        +   K    T+  L     Y+FR+ A N  G G+ +      K TE +  
Sbjct: 23769 VDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEY 23828

Query: 686   PEEPPTAPPQN---VIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFK 742
             P+       Q    V   G    +I I+ +P P           I ++   G  +  +  
Sbjct: 23829 PDYELDERYQEGIFVRQGGVIRLTIPIKGKPFP-----------ICKWTKEGQDISKRAM 23877

Query: 743   NITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEA 802
               T      L++++     +   ++   N  G      KV    + G P  P G +  + 
Sbjct: 23878 IATSETHTELVIKEADRGDSGTYDLVLENKCGKKAVYIKV---RVIGSPNSPEGPLEYDD 23934

Query: 803   TNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEE--EVTMVTARPNFQDSIHVGFVSG 860
                 ++R +W  P+       + G  ++ +  E+ E  +    T     + +  V  V G
Sbjct: 23935 IQVRSVRVSWRPPAD------DGGADILGYILERREVPKAAWYTIDSRVRGTSLV--VKG 23986

Query: 861   LKKFTEYFTSVLCFTTPG-DGPRSTPQLVRTHEDVPGPVGHLSFSEILD---TSLKVSWQ 916
             LK+  EY   V      G   P  + + V     +  P    +  E+LD   +S+ +SW 
Sbjct: 23987 LKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWS 24046

Query: 917   EPGEKNGI-LTGYRISWEEYNRTNTRVTHYLPNVTLE-YRVTGLTALTTYTIEVAAMTSK 974
              P +  G  +TGY I  +E   T+  V H    +T   Y VTGL     Y   + A    
Sbjct: 24047 RPKDDGGSRVTGYYIERKE-TSTDKWVRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDV 24105

Query: 975   GQGQVSAST--ISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYD-GKTSISRWLVEA 1030
             G  + S ++  +    P + P  P  L I +I   SVTLQ+ +P  D GK  +  W+   
Sbjct: 24106 GLSETSPASEPVVCKDPFDKPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYR 24165

Query: 1031  QVGVVGEGEEWLLIHQLSNEPDARSME--VPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
             Q G       W    + SN+   +  +  +  L   T Y FR+   N  G S P + +  
Sbjct: 24166 QSG----DSAW----KKSNKERIKDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMS 24217

Query: 1089  IQTL----QAP---PDMAPANVSLRTASETSLWLRWMPLPEME-YNGNPESVGYKIKYSR 1140
             I+T     +AP    +M      L  A++ S  +   PLP+++ Y    E +  +     
Sbjct: 24218 IKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMS 24277

Query: 1141  SDGHGKTLSHVVQDRVERDY-----TIEDLEEWTEYRVQVQAFNAIGSG-PWSQTVVGRT 1194
             SDG   TL+ + +++ +        T E  E  T  ++ +QA      G P  +   G  
Sbjct: 24278 SDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYG-- 24335

Query: 1195  RESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKD---SDTQPRFW 1251
               +V S+   +V  +     +M   W             G K++   ++    +T+    
Sbjct: 24336 --AVGSTLRLHVMYIGRPVPAM--TWFH-----------GQKLLQNSENITIENTEHYTH 24380

Query: 1252  LVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMG-ILFP 1310
             LV  N  R    T  GKY +    V           +   IL+  + D P  P G I+  
Sbjct: 24381 LVMKNVQRK---THAGKYKVQLSNVFG---------TVDAILDVEIQDKPDKPTGPIVIE 24428

Query: 1311  EVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESV 1370
              +   S  + W+PPA   G  +   +  +          +   A S        L   + 
Sbjct: 24429 ALLKNSAVISWKPPADDGGSWITNYVVEKCEAKEGAEWQLVSSAISVTTCRIVNLTENAG 24488

Query: 1371  YLFRITAQTRKGWGEAAE--ALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWE-PGSD 1427
             Y FR++AQ   G  +  E  ++V+     ++P  P +P +    V   S +++W+ P SD
Sbjct: 24489 YYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGAPGKPTITA--VTKDSCVVAWKPPASD 24546

Query: 1428  GLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEF 1487
             G + +R Y ++ RE    +W +   +     + F V  L     Y+FRVK  N  G+SE+
Sbjct: 24547 GGAKIRNYYLEKREKKQNKW-ISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEW 24605

Query: 1488  SEESESLTTLQAAPDEAP 1505
             SE SE +T     P +AP
Sbjct: 24606 SEISEPITPKSDVPIQAP 24623



 Score =  154 bits (390), Expect = 7e-37
 Identities = 325/1603 (20%), Positives = 591/1603 (36%), Gaps = 176/1603 (10%)

Query: 317   HITAEMEKVVDIPCQAKGVPPPSITWYKDAAVV-EVEKLTRFRQRNDGGLQISGLVPDDT 375
             ++ A  +  +D+P   KG P  ++ W KD   + E  ++     +    L I     +D 
Sbjct: 19100 NVKAREQLKIDVPF--KGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDV 19157

Query: 376   GMFQCFARNAAGEVQTS-TYLAVTSIAPNITRGPLDSTVIDGMSVVLA---------CET 425
             G ++    N+AG +    T + +    P    GP+    +   S+ ++         C+ 
Sbjct: 19158 GTYELCVSNSAGSITVPITIIVLDRPGPP---GPIRIDEVSCDSITISWNPPEYDGGCQI 19214

Query: 426   SG-----APRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNS 480
             S          + TW    + +A  S+++ R T   +GS             +   A N 
Sbjct: 19215 SNYIVEKKETTSTTWHIVSQAVARTSIKIVRLT---TGSEY----------QFRVCAENR 19261

Query: 481   RGVDEASADLVVWARTRITKP--PQDQSVIKGTQASM--------------VCGVTHDPR 524
              G    S    V A    + P  P    V+  T+++M              V G   + +
Sbjct: 19262 YGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYK 19321

Query: 525   VTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAH- 583
                  +W K    L  ++  ++     G ++  + ++ +I           G  S+S   
Sbjct: 19322 ERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGI--------GKCSKSCEP 19373

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLAS 642
             +  R     P  P  T   + R++++L W+KP +DG + +  YI+E  E      +    
Sbjct: 19374 VPARDPCDPPGQPEVT--NITRKSVSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNY 19431

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGK-GQFSKDTERVSLPEEPPTAPPQNVIASG 701
              + + T   V  L   + Y+FR+ A N      + S+ T  + + ++     P  V+   
Sbjct: 19432 TNIQETYFEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDD---VEPPRVMMDV 19488

Query: 702   RTNQSIMIQWQPPPESHQNGILKGY---IIRYCLAGLPVGYQFKN-ITDADVNNLL-LED 756
             +    I+++     +   N  + G    +I +   G+ +  + +  I   D + LL ++D
Sbjct: 19489 KFRDVIVVKAGEVLKI--NADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKD 19546

Query: 757   LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPS 816
              I     +  +   N AG     S      +   P  P G +      +     +W  P 
Sbjct: 19547 CIRRDTGQYVLTLKNVAGT---RSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQ 19603

Query: 817   PQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTT 876
                  G +  Y ++  E  +   +         Q +     V+ L K  EY   V     
Sbjct: 19604 ED--GGADIDYYIV--EKRETSHLAWTICEGELQMTSCK--VTKLLKGNEYIFRVTGVNK 19657

Query: 877   PGDGPRSTPQLVRTHED--VPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWE 933
              G G       ++  +   VP P   L  + +   S+ + W  P    G  ++GY I   
Sbjct: 19658 YGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERR 19717

Query: 934   EYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAST--ISSGVPPE 991
             E N       +  P   L  + TGL     Y   V A  + G    S ++  I +  P  
Sbjct: 19718 EKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVF 19777

Query: 992   LPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNE 1050
             LP PP+   I + G  ++T+ + +P +DG   I+ + VE +     +  +W    Q    
Sbjct: 19778 LPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKS---DDTDWKTSIQSLRG 19834

Query: 1051  PDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPS-------RKIQTL-QAPPDMAPAN 1102
              +     +  L     Y FR++ VN VG S PS  S       R+ + L     +M    
Sbjct: 19835 TE---YTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTL 19891

Query: 1103  VSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTI 1162
             +    AS T      M +P   + G P      + +S+ D   +T ++V         TI
Sbjct: 19892 IVKAGASFT------MTVP---FRGRPVP---NVLWSKPDTDLRTRAYVDTTDSRTSLTI 19939

Query: 1163  EDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSE 1222
             E+       +  +   N + +   S T+V +  ++     PTN++    T  S ++ W +
Sbjct: 19940 ENANRNDSGKYTLTIQNVLSAA--SLTLVVKVLDT--PGPPTNITVQDVTKESAVLSW-D 19994

Query: 1223  VPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSR-SAQLTGLGKYVLYEVQVLAFTR 1281
             VPE D    V  Y +   EK   ++  +  V  N +R S ++T L +  +Y  +V     
Sbjct: 19995 VPENDGGAPVKNYHI---EKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENE 20051

Query: 1282  IGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLN 1341
              G G P+      + + + P PP  +    +   SV L W  P    G  + + +   L 
Sbjct: 20052 FGVGIPAETKEGVK-ITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALE 20110

Query: 1342  TTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQ 1401
                 N   V+     +  +  +GL+  S Y FR+ A+ + G  +  E L+    K ++ +
Sbjct: 20111 KGQKNW--VKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDPRELLLPVLIK-EQLE 20167

Query: 1402  PPSRPMVQQED----VRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHN 1457
             PP   M         VRA S L    P S    P+   T+    +P       +  ++  
Sbjct: 20168 PPEIDMKNFPSHTVYVRAGSNLKVDIPISG--KPLPKVTLSRDGVPLKATMRFNTEITAE 20225

Query: 1458  ASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTS 1517
               +  +       + ++ + A N  G ++       L   +  P   P ++S    T  S
Sbjct: 20226 NLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLD--RPGPPTGPVVISDI--TEES 20281

Query: 1518  VLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLS 1577
             V ++W+PP  D  + +                  + L       A W E+++  +   + 
Sbjct: 20282 VTLKWEPPKYDGGSQVT----------------NYILLKRETSTAVWTEVSATVARTMMK 20325

Query: 1578  RPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVV-VHGAT 1636
                LT  E         Y+ R+   N  G         V V     T  P +   V   T
Sbjct: 20326 VMKLTTGE--------EYQFRIKAENRFGISDHIDSACVTVKLPYTTPGPPSTPWVTNVT 20377

Query: 1637  ATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAY 1696
                + V W  P + +    + GY +   + +   L ++   L +     K+  ++    Y
Sbjct: 20378 RESITVGWHEP-VSNGGSAVVGYHLEMKD-RNSILWQKANKLVIRTTHFKVTTISAGLIY 20435

Query: 1697  MVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LE 1755
                V A NAAG G  S P++      A   P +V+ ++++  SV++SW+ P F  G  + 
Sbjct: 20436 EFRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISKNSVSLSWQQPAFDGGSKIT 20495

Query: 1756  GYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK----TFTYGPE 1811
             GY  + E     DG  +         +     +  L +   Y FR+ A+    + +   E
Sbjct: 20496 GY--IVERRDLPDG--RWTKASFTNVTETQFIISGLTQNSQYEFRVFARNAVGSISNPSE 20551

Query: 1812  IEANVTTGPGEGAPG---PPGVPIIVRYSSAIAIHWSSGDPGK 1851
             +   +T     G P    P     +V+Y +  ++   +G  GK
Sbjct: 20552 VVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGK 20594



 Score =  149 bits (376), Expect = 3e-35
 Identities = 359/1701 (21%), Positives = 599/1701 (35%), Gaps = 236/1701 (13%)

Query: 305   LEPPQFVKEPERH--ITAEMEKVVDIPCQAKGVPPPSITWYKDAAVVEVEKLTR---FRQ 359
             +EPP+ + + +    I  +  +V+ I     G P P I+W KD   +E+E+  R      
Sbjct: 19479 VEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDG--IEIEERARTEIIST 19536

Query: 360   RNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSV 419
              N   L +   +  DTG +    +N AG    +    V    P    GPL+   +     
Sbjct: 19537 DNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLD-KPGPPAGPLEINGLTAEKC 19595

Query: 420   VLAC----ETSGAPRPAITWQKGER-----ILASGSVQLP--RFTPLESGSLLISPTHIS 468
              L+     E  GA       +K E       +  G +Q+   + T L  G+  I      
Sbjct: 19596 SLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYI------ 19649

Query: 469   DAGTYTCLATNSRGVDEASADLVVWARTRIT--KPPQDQSVIKGTQASMVCGVTHDPRVT 526
                 +     N  GV E    + + A    T   PP    +   T+ SM           
Sbjct: 19650 ----FRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMT---------- 19695

Query: 527   IRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRV 586
                 W +  +  G+E    I ++R     +          Y  RV S G  +      RV
Sbjct: 19696 --LCWSRPESDGGSEISGYI-IERREKNSLRWVRVNKKPVYDLRVKSTGLREGCEYEYRV 19752

Query: 587   RQ-----------------------LPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPL 622
                                      LP  P  P    S   +  I + W KP FDG +P+
Sbjct: 19753 YAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDS--GKTTITIAWVKPLFDGGAPI 19810

Query: 623   IRYILEMSE-NNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681
               Y +E  + ++  W   + S+  + T  T+ GL     Y FR+ +VN VG    S  ++
Sbjct: 19811 TGYTVEYKKSDDTDWKTSIQSL--RGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSD 19868

Query: 682   RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILK---GYIIRYCLAGLPVG 738
                         PQ  IA  R  + +   +    E  +  I+K    + +     G PV 
Sbjct: 19869 ------------PQ--IAKEREEEPL---FDIDSEMRKTLIVKAGASFTMTVPFRGRPVP 19911

Query: 739   YQFKNITDADVNNLLLEDLI-IWTNYEIEVAAYNSAG------LGVYSSKVTEWTLQGVP 791
                 +  D D+      D     T+  IE A  N +G        V S+      ++ + 
Sbjct: 19912 NVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLTLVVKVLD 19971

Query: 792   TV-PPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQ 850
             T  PP N+  +     +   +W+ P     N      K    E  +  +   V+   N  
Sbjct: 19972 TPGPPTNITVQDVTKESAVLSWDVPE----NDGGAPVKNYHIEKREASKKAWVSVTNNCN 20027

Query: 851   DSIHVGFVSGLKKFTEYFTSVLCFTTPGDG-PRSTPQLVRTHEDVPGPVGHLSFSEILDT 909
                +   V+ L++   Y+  V      G G P  T + V+  E  P P   L  + I   
Sbjct: 20028 RLSYK--VTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKITEK-PSPPEKLGVTSISKD 20084

Query: 910   SLKVSWQEPGEKNGI-LTGYRISWEEYNRTN------TRVTHYLPNVTLEYRVTGLTALT 962
             S+ ++W +P    G  +  Y +   E  + N       + TH++        V+GL   +
Sbjct: 20085 SVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHV--------VSGLRENS 20136

Query: 963   TYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTS 1022
              Y   V A    G        +   +  +L   P  + + N    S T+  R G + K  
Sbjct: 20137 EYFFRVFAENQAGLSDPRELLLPVLIKEQL--EPPEIDMKNF--PSHTVYVRAGSNLKVD 20192

Query: 1023  IS-RWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSP 1081
             I        +V +  +G       + + E  A ++ +      T  + R  ++    +S 
Sbjct: 20193 IPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRY-EITAANSSG 20251

Query: 1082  PSQPSRKIQTLQAP-PDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGY-KIKYS 1139
              ++    I  L  P P   P  +S    +E S+ L+W P    +Y+G  +   Y  +K  
Sbjct: 20252 TTKAFINIVVLDRPGPPTGPVVIS--DITEESVTLKWEP---PKYDGGSQVTNYILLKRE 20306

Query: 1140  RSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVP 1199
              S      +S  V   + +   +  L    EY+ +++A N  G      +     +    
Sbjct: 20307 TSTAVWTEVSATVARTMMK---VMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLPYT 20363

Query: 1200  SSGPTNVSALA-TTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN-- 1256
             + GP +   +   T  S+ V W E P ++    V+GY +  K+++S      W       
Sbjct: 20364 TPGPPSTPWVTNVTRESITVGWHE-PVSNGGSAVVGYHLEMKDRNS----ILWQKANKLV 20418

Query: 1257  -SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHP--PILERTLDDVPGPPMGILFPEVR 1313
               +   ++T +   ++YE +V A    G G PSHP  P+L     D   PP  +   ++ 
Sbjct: 20419 IRTTHFKVTTISAGLIYEFRVYAENAAGVGKPSHPSEPVL---AIDACEPPRNVRITDIS 20475

Query: 1314  TTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLF 1373
               SV L WQ PA   G  +   I  R +              +  Q+  +GL   S Y F
Sbjct: 20476 KNSVSLSWQQPAFDGGSKITGYIVERRDLPDGRWTKASFTNVTETQFIISGLTQNSQYEF 20535

Query: 1374  RITAQTRKGWGEAAEALVVTTEKRDRPQPP--SRPMVQQEDVRARS-VLLSWEPGSDGL- 1429
             R+ A+   G       +V      D    P    P+   E V+ R+   +    G  G  
Sbjct: 20536 RVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISGKP 20595

Query: 1430  SPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSE 1489
             +P   +    +EL +   AL     + + +S ++       S  + +K  N +G +  + 
Sbjct: 20596 APTIEWYKDDKELQTN--ALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATI 20653

Query: 1490  ESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGL 1549
               + L   +  P   P  +     T   + + W+PPA+D       G +I +        
Sbjct: 20654 RVQILD--KPGPPGGP--IEFKTVTAEKITLLWRPPADDG------GAKITH-------- 20695

Query: 1550  RGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGP 1609
               + +         W+ ++      +L    +T      + K   Y  R+   N  G G 
Sbjct: 20696 --YIVEKRETSRVVWSMVS-----EHLEECIIT---TTKIIKGNEYIFRVRAVNKYGIGE 20745

Query: 1610  SSPPQEVFVGEAVPTAAPRNV-VVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR 1668
                   V    A  T  P  +  V   T   + V W  P  D    DI G   YF E + 
Sbjct: 20746 PLESDSVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADG-GSDISG---YFLEKRD 20801

Query: 1669  GNLTERVKTL--FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQ---GQTQQAA 1723
                    K L   + +   K+  LT  + Y   V A NAAG GP S P++          
Sbjct: 20802 KKSLGWFKVLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDP 20861

Query: 1724  PSAPSSVKFSELTTTSVNVSWEAPQFPNG-ILEGYRLVYEPCSPVDGVSKIVTVDVKGN- 1781
             P  P+ ++ ++ T +S+ + W  P +  G  + GY +            +  TV  KG  
Sbjct: 20862 PGPPAKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEE----EEWTTVSTKGEV 20917

Query: 1782  SPLWLKVKDLAEGVTYRFR------------------IRAKTFTYGPEIEANVTTGPGEG 1823
                   V +L  GV Y FR                  ++AK     PEI+ +V       
Sbjct: 20918 RTTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVI 20977

Query: 1824  APGPPGVPIIVRYSS--AIAIHWSSGDPGKGPITRYVIEARPS------------DEGLW 1869
             A     V +++ +       + W   +   G   RY IE   S            D G +
Sbjct: 20978 AKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY 21037

Query: 1870  DILIKDIPKEVSSYTFSMDIL 1890
              + I++   E  S T S+ +L
Sbjct: 21038 ILTIENGVGEPKSSTVSVKVL 21058



 Score =  149 bits (376), Expect = 3e-35
 Identities = 360/1644 (21%), Positives = 594/1644 (36%), Gaps = 223/1644 (13%)

Query: 367   ISGLVPDDTGMFQCFARNAAG-----EVQTSTYLAVTSIAPNITRGPLDSTVID---GMS 418
             ++ L   +  +F+  A+N  G     E  T+  +    + P I    +    I    G  
Sbjct: 23391 VTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAGRP 23450

Query: 419   VVLACETSGAPRPAITWQ-KGERILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLA 477
             V L    +G P PA +W   G ++  S  V +   T +    L I  T I D G YT   
Sbjct: 23451 VELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKV--AKLTIRETTIRDTGEYTLEL 23508

Query: 478   TNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASM------------VCGVTHDPRV 525
              N  G    +  +++  +      P     I  T  ++            + G   + R 
Sbjct: 23509 KNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRD 23568

Query: 526   TIRYIW--EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGNDSRSAH 583
               R  W    +  T  T    R+         ++ T    IG+Y    + +   + RS+ 
Sbjct: 23569 AHRPGWLPVSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSY----LQSEVIECRSSI 23624

Query: 584   LRVRQLPHAPEHPVATLSTVERRAINLTWTKPFD-GNSPLIRYILEMSENNAPWTVLLAS 642
                 ++P  PE     +  V R  + LTW  P D G S +  YI+E  E  A   V +  
Sbjct: 23625 ----RIPGPPE--TLQIFDVSRDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNK 23678

Query: 643   VDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTER-VSLPEEPPTAPPQNVIASG 701
             V    T     GL     Y+ R+ A+N  G G+ S+ ++  V++    P   PQN   + 
Sbjct: 23679 VPVTMTRYRSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPRVTD 23738

Query: 702   RTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWT 761
              T  S+ + W  P E      + GY+I           +  N T   +    L  L    
Sbjct: 23739 TTRTSVSLAWSVP-EDEGGSKVTGYLIEMQKVDQHEWTKC-NTTPTKIREYTLTHLPQGA 23796

Query: 762   NYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFIN 821
              Y   V A N+ G              G P   PG V      +  + +       ++  
Sbjct: 23797 EYRFRVLACNAGG-------------PGEPAEVPGTVKV----TEMLEYPDYELDERYQE 23839

Query: 822   GI--NQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGD 879
             GI   QG  +    P + +   +       QD      ++  +  TE    V+     GD
Sbjct: 23840 GIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTEL---VIKEADRGD 23896

Query: 880   ------------GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LT 926
                         G ++    VR       P G L + +I   S++VSW+ P +  G  + 
Sbjct: 23897 SGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADIL 23956

Query: 927   GYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQV--SASTI 984
             GY +   E  +            T    V GL     Y   V+A    G  +   S   +
Sbjct: 23957 GYILERREVPKAAWYTIDSRVRGT-SLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPV 24015

Query: 985   SSGVPPELPGPPTNLG-ISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWL 1042
             +   P   P PP+N   + ++   SV+L + RP  DG + ++ + +E +       ++W 
Sbjct: 24016 TPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETST---DKW- 24071

Query: 1043  LIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVG---TSPPSQPSRKIQTLQAPPDMA 1099
              +     +       V  L P   Y FR+   N VG   TSP S+P         P    
Sbjct: 24072 -VRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQ-- 24128

Query: 1100  PANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV-ER 1158
             P  + + + S+ S+ L+W    + E +G  E +GY ++Y +S       S+  ++R+ ++
Sbjct: 24129 PGELEILSISKDSVTLQW---EKPECDGGKEILGYWVEYRQSGDSAWKKSN--KERIKDK 24183

Query: 1159  DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGP----------TNVSA 1208
              +TI  L E TEY  +V A N  G     +T +    +      P          T +  
Sbjct: 24184 QFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGE 24243

Query: 1209  LATTSSSMLVRWSEVPEADRNGLVLGYKVMYK-EKDSDTQPRFWLVEGNSSRSAQLTGLG 1267
              A  S  ++ R     +  R G  L     YK   D  T     + E            G
Sbjct: 24244 AAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDE-------G 24296

Query: 1268  KYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRL----IWQP 1323
              Y       +A   +G+   S   +L+ T    PG P+   +     +++RL    I +P
Sbjct: 24297 VYTC-----IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRP 24351

Query: 1324  PAAPNGIILAYQITHRLNTTTANTAT-VEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382
               A         + +  N T  NT     ++  + ++ T  G        +++      G
Sbjct: 24352 VPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGK-------YKVQLSNVFG 24404

Query: 1383  WGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEP-GSDGLSPVRYYTIQTRE 1441
               +A    ++  E +D+P  P+ P+V  E +   S ++SW+P   DG S +  Y ++  E
Sbjct: 24405 TVDA----ILDVEIQDKPDKPTGPIVI-EALLKNSAVISWKPPADDGGSWITNYVVEKCE 24459

Query: 1442  LPSG-RWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA 1500
                G  W L S+++S      +   L     Y FRV A N  G S+  E S     +  +
Sbjct: 24460 AKEGAEWQLVSSAISVTTCRIV--NLTENAGYYFRVSAQNTFGISDPLEVSS--VVIIKS 24515

Query: 1501  PDE---APTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGI 1557
             P E   AP   ++T  T  S ++ W+PPA D       G +IR           + L   
Sbjct: 24516 PFEKPGAPGKPTITAVTKDSCVVAWKPPASDG------GAKIR----------NYYLEKR 24559

Query: 1558  NNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVF 1617
                   W  +T+            T + + NL +   YE R+   N  GE   S   E  
Sbjct: 24560 EKKQNKWISVTTEEIRE-------TVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPI 24612

Query: 1618  VGEA-VPTAAPR--------NVVVHGATATQLDVTWEPPPL------------DSQNGDI 1656
               ++ VP  AP         NV           VT  P P+            D     I
Sbjct: 24613 TPKSDVPIQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRI 24672

Query: 1657  QGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQ 1716
             Q +K  + +    ++T+   T++    + +  +++G  +  V V A       P++    
Sbjct: 24673 QEFKGGYHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHL---PKTLEGM 24729

Query: 1717  GQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTV 1776
             G    A      S+K          ++W+  Q        Y+++         V++  T 
Sbjct: 24730 GAVH-ALRGEVVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVI---------VTRSFTS 24779

Query: 1777  DVKGNSPLWLKVKDLAEGVTY---RFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPII 1833
              V  N    ++ KD    V     RF I  KT      +E +V   P      P GV + 
Sbjct: 24780 LVFPNG---VERKDAGFYVVCAKNRFGIDQKT------VELDVADVPDP----PRGVKVS 24826

Query: 1834  VRYSSAIAIHWSS-GDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKP 1892
                  ++ + W+     G   IT Y++E   +    W  +      +     +++  L  
Sbjct: 24827 DVSRDSVNLTWTEPASDGGSKITNYIVEKCATTAERWLRV-----GQARETRYTVINLFG 24881

Query: 1893  GVSYDFRVIAVNDYGFGTPSSPSQ 1916
               SY FRVIA N +G   PS PS+
Sbjct: 24882 KTSYQFRVIAENKFGLSKPSEPSE 24905



 Score =  147 bits (372), Expect = 8e-35
 Identities = 327/1497 (21%), Positives = 538/1497 (35%), Gaps = 177/1497 (11%)

Query: 361   NDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVV 420
             ND G+    ++PD     +   R  A + +    L  T +            V  G+S+ 
Sbjct: 14447 NDAGVGEPAVIPD----VEIVEREMAPDFELDAELRRTLV------------VRAGLSIR 14490

Query: 421   LACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPT-HISDAGTYTCLATN 479
             +     G P P +TW K    L + +         ES +LLI P  +  D G +     N
Sbjct: 14491 IFVPIKGRPAPEVTWTKDNINLKNRA----NIENTESFTLLIIPECNRYDTGKFVMTIEN 14546

Query: 480   SRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTH--------DPRVTIRYIW 531
               G          +   R+   P     ++ T  +      H          R+T  YI 
Sbjct: 14547 PAGKKSG------FVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRIT-NYIV 14599

Query: 532   EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISA-----GGNDSRSAHLRV 586
             EK  AT  + S    +  +        T   +   Y  RV++      G     +  ++ 
Sbjct: 14600 EKREATRKSYSTATTKCHK---CTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKA 14656

Query: 587   RQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIRYILEMSENNAPWTVLLASVDP 645
              + P  P+     +  + +  ++L W KP  DG S +  Y++E     +     + +V  
Sbjct: 14657 SEAPSPPDS--LNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTV-- 14712

Query: 646   KATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT-----ERVSLPEEPPTAPPQN-VIA 699
             K     V+ L     Y F++ AVN  G+    +       E+  LPE       Q  VIA
Sbjct: 14713 KGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIA 14772

Query: 700   SGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLII 759
                 N  + I     P+          I++       V ++    T A    L + + + 
Sbjct: 14773 KAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQR---VNFE----TTATSTILNINECVR 14825

Query: 760   WTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQF 819
               +    + A N  G       V    +  +P  P G +  +  +S  + F+W+ P    
Sbjct: 14826 SDSGPYPLTARNIVG---EVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPEND- 14881

Query: 820   INGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGD 879
               G+     ++  E  Q +  T V        + +    + L    EY   V      G 
Sbjct: 14882 -GGVPISNYVV--EMRQTDSTTWVELATTVIRTTYKA--TRLTTGLEYQFRVKAQNRYGV 14936

Query: 880   GPRSTPQLVRTHED--VPGPVGHLSFSEILDTSLKVSWQEPGEKNGI-LTGYRISWEEYN 936
             GP  T   +  +    VPGP G    + +   S+ +SW EP    G  + GY +  +E N
Sbjct: 14937 GPGITSACIVANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERN 14996

Query: 937   RTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAA--MTSKGQGQVSASTISSGVPPELPG 994
                 +           ++ +GLT    Y   V A  M  K +    +  + +  P + PG
Sbjct: 14997 GILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPG 15056

Query: 995   PPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDA 1053
              P  L   NI   +VTL++ +P Y G   I+ ++VE +    G   +    + L NE   
Sbjct: 15057 KPVPL---NITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILENE--- 15110

Query: 1054  RSMEVPDLNPFTCYSFRMRQVNIVGT-SPPSQPSRKI---QTLQAPP---DMAPANVSLR 1106
                 V  L     Y FR+   N  G  SPPS+PS  I     ++AP    D+   +  + 
Sbjct: 15111 --FTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTVIL 15168

Query: 1107  TASET---SLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIE 1163
              A E       +   P P ME++ + + +    K          ++    + V +D T  
Sbjct: 15169 KAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIK------IADFSTNLVNKDSTRR 15222

Query: 1164  DLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEV 1223
             D   +T     + A N  G       V    R   P  GP  V+ +  TS   ++ W   
Sbjct: 15223 DSGAYT-----LTATNPGGFAKHIFNVKVLDRPG-PPEGPLAVTEV--TSEKCVLSW--F 15272

Query: 1224  PEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQL--TGLGKYVLYEVQVLAFTR 1281
             P  D  G  + + ++ K    +T    W    +  +  +L  T L K   Y  +V+A  +
Sbjct: 15273 PPLDDGGAKIDHYIVQKR---ETSRLAWTNVASEVQVTKLKVTKLLKGNEYIFRVMAVNK 15329

Query: 1282  IGDGSP-SHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRL 1340
              G G P    P+L       P PP       +   S+ + W  P +  G  +   I  R 
Sbjct: 15330 YGVGEPLESEPVLAVNPYGPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERR 15389

Query: 1341  NTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWG--EAAEALVVTTEKRD 1398
             +              +  +Y  +GL     Y FRI A+   G              +   
Sbjct: 15390 DKAGQRWIKCNKKTLTDLRYKVSGLTEGHEYEFRIMAENAAGISAPSPTSPFYKACDTVF 15449

Query: 1399  RPQPPSRPMVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHN 1457
             +P PP  P V   D    S+ ++W +P  DG S +  Y ++        W + +      
Sbjct: 15450 KPGPPGNPRVL--DTSRSSISIAWNKPIYDGGSEITGYMVEIALPEEDEWQIVTPPAGLK 15507

Query: 1458  ASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTS 1517
             A+S+ +  L     YK R+ A N  G  E                  P ++  TP     
Sbjct: 15508 ATSYTITGLTENQEYKIRIYAMNSEGLGE------------------PALVPGTPKAEDR 15549

Query: 1518  VLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFT-LRGINNPGATWAELTSMYSMRNL 1576
             +L     P E +++  L    +  R      LR F  ++G   P   WA      S+   
Sbjct: 15550 ML-----PPEIELDADLRKV-VTIRACC--TLRLFVPIKGRPAPEVKWAR-DHGESLDKA 15600

Query: 1577  SRPSLTQYEL---DNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAV--PTAAPRNVV 1631
             S  S + Y L    N+N+    +  ++V N      SS  +  FV   V      P+++ 
Sbjct: 15601 SIESTSSYTLLIVGNVNRFDSGKYILTVEN------SSGSKSAFVNVRVLDTPGPPQDLK 15654

Query: 1632  VHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLA---ENSVKLK 1688
             V   T T + +TW+PP LD       G KI  +  ++   T +  +       + S K+ 
Sbjct: 15655 VKEVTKTSVTLTWDPPLLDG------GSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVD 15708

Query: 1689  NLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQ 1748
              L    +Y   V A N  G G  +   +       P  P  +   ++T  SV++SWE P+
Sbjct: 15709 QLQEGCSYYFRVLAENEYGIGLPAETAESVKASERPLPPGKITLMDVTRNSVSLSWEKPE 15768

Query: 1749  FPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK 1804
                G  + GY +V       D  +   TV V   +     +  L +G  Y FR+ A+
Sbjct: 15769 HDGGSRILGY-IVEMQTKGSDKWATCATVKVTEAT-----ITGLIQGEEYSFRVSAQ 15819



 Score =  142 bits (357), Expect = 5e-33
 Identities = 357/1681 (21%), Positives = 598/1681 (35%), Gaps = 218/1681 (12%)

Query: 289   RSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAAV 348
             RS +VP V +     V+EP   VK      + ++ + + I     G P P+ITW KD   
Sbjct: 16910 RSLAVPIVAKDL---VIEPD--VKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDG-- 16962

Query: 349   VEVEKLTRFRQRND---GGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNIT 405
             + +++ TR    +      L I     DD G +     N  G+ +T++   VT   P+  
Sbjct: 16963 LPLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQ-KTASIEIVTLDKPDPP 17021

Query: 406   RGPLDSTVIDGMSVVLACE----TSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLL 461
             +GP+    +   S+ L+      T G        QK +       V       +   +L 
Sbjct: 17022 KGPVKFDDVSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVV---SATVARTTLK 17078

Query: 462   ISPTHISDAGTYTCLATNSRGVDEA--SADLVVWARTRITKPP---------QDQSVIK- 509
             ++         +   A N  G   A  S  +V     +   PP         +D  VI+ 
Sbjct: 17079 VTKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQW 17138

Query: 510   ----GTQASMVCGVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIG 565
                     S V G   + +     +W K   T+  ++  + +       ++ +    +  
Sbjct: 17139 HEPVNNGGSPVIGYHLERKERNSILWTKVNKTIIHDTQFKAQ-------NLEEGIEYEFR 17191

Query: 566   TYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKP-FDGNSPLIR 624
              Y   ++  G     S     R     P  P   +  V+R  I L WTKP +DG S +  
Sbjct: 17192 VYAENIVGVGKASKNSECYVARDPCDPPGTPEPIM--VKRNEITLQWTKPVYDGGSMITG 17249

Query: 625   YILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT---- 680
             YI+E  +      +  +  +   T  TV GL   + Y+FR+ A N  G      D+    
Sbjct: 17250 YIVEKRDLPDGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPI 17309

Query: 681   ---ERVSLP--EEPPTAPPQNVIASGRT-NQSIMIQWQPPPESHQNGILKGYIIRYCLAG 734
                + V LP     P      V+ +G T      +  +P P                +  
Sbjct: 17310 TAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLP---------------TIEW 17354

Query: 735   LPVGYQFKNITDADVNN------LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQ 788
             L    + +     ++ N      L+++D I     +  + A N AG   +   V    + 
Sbjct: 17355 LRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNV---KVL 17411

Query: 789   GVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPN 848
               P  P G V      S     TW   SP   +G +     +  + E       V A   
Sbjct: 17412 DRPGPPEGPVQVTGVTSEKCSLTW---SPPLQDGGSDISHYVVEKRETSRLAWTVVASEV 17468

Query: 849   FQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGP--RSTPQLVRTHEDVPGPVGHLSFSEI 906
               +S+    V+ L +  EY   ++     G G    S P L++    +PGP   L  + I
Sbjct: 17469 VTNSLK---VTKLLEGNEYVFRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNI 17525

Query: 907   LDTSLKVSWQEPGEKNGI-LTGYRISWEEYNRTNTR-VTHYLPNVT-LEYRVTGLTALTT 963
                S+ V W  P    G  + GY +  E+ +R+  R +      +T L  RVTGLT    
Sbjct: 17526 AKDSMTVCWNRPDSDGGSEIIGYIV--EKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHE 17583

Query: 964   YTIEVAAMTSKGQGQVSASTI--SSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGK 1020
             Y   V+A  + G G+ S +T+   +  P   PGPPTN  I +    S+TL + +P YDG 
Sbjct: 17584 YEFRVSAENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYDGG 17643

Query: 1021  TSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVG-- 1078
             + I  ++VE       + EEW ++   +     R  E+  L     Y  R+  +N VG  
Sbjct: 17644 SEILGYVVEI---CKADEEEWQIVTPQTGLRVTR-FEISKLTEHQEYKIRVCALNKVGLG 17699

Query: 1079  --TSPPS--QPSRKIQTLQAPPDM-APANVSLRTASETSLWLRWMPLPEMEYNGNPESVG 1133
               TS P   +P  K++  +   D      + +R      +         + + G P    
Sbjct: 17700 EATSVPGTVKPEDKLEAPELDLDSELRKGIVVRAGGSARI--------HIPFKGRPTP-- 17749

Query: 1134  YKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGR 1193
              +I +SR +G       + +       +I++ +     +  ++  N+ GS     TV   
Sbjct: 17750 -EITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTV--- 17805

Query: 1194  TRESVPSSG-PTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWL 1252
               + + + G P N++       S  + W E P  D    V  Y +   +K   T+  +  
Sbjct: 17806 --KVLDTPGPPQNLAVKEVRKDSAFLVW-EPPIIDGGAKVKNYVI---DKRESTRKAYAN 17859

Query: 1253  VEGNSSR-SAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPE 1311
             V    S+ S ++  L +  +Y  +V+A    G G P       +  +  P PP  +   +
Sbjct: 17860 VSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEP-PSPPGKVTLTD 17918

Query: 1312  VRTTSVRLIWQPPAAPNGI-ILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESV 1370
             V  TS  L+W+ P    G  +L Y +  +   T   +   E    +A     TGL     
Sbjct: 17919 VSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNA---VVTGLSSGQE 17975

Query: 1371  YLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVL----------- 1419
             Y FR+ A   KG  +     V    K    QP  +       ++A   L           
Sbjct: 17976 YQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPR 18035

Query: 1420  --LSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVK 1477
               +SW    DG  P++  T    E  +    LH      N   F           K+ V 
Sbjct: 18036 PNISWV--KDG-EPLKQTTRVNVEETATSTVLHIK--EGNKDDF----------GKYTVT 18080

Query: 1478  ATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGF 1537
             ATN  G +  +E    +   +  P   P        +   V+I W+PPA           
Sbjct: 18081 ATNSAGTA--TENLSVIVLEKPGPPVGPVRFDEV--SADFVVISWEPPA----------- 18125

Query: 1538  RIRYRELLYEG---LRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRR 1594
                     Y G   +  + +   +    TW  +++  +         T  ++  L     
Sbjct: 18126 --------YTGGCQISNYIVEKRDTTTTTWHMVSATVAR--------TTIKITKLKTGTE 18169

Query: 1595  YEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNV-VVHGATATQLDVTWEPPPLDSQN 1653
             Y+ R+   N  G+      + V V        P     V   +  Q+ V W  P  D   
Sbjct: 18170 YQFRIFAENRYGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDG-G 18228

Query: 1654  GDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRST 1713
               I GY +   E +   L  ++    + +   K   L     Y   V+A N  G G  S 
Sbjct: 18229 TKIIGYHLEQKE-KNSILWVKLNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSK 18287

Query: 1714  PTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSK 1772
              ++    +     P   +   +T  +V + W+ P +  G  + GY  + E     DG  +
Sbjct: 18288 VSECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGY--IVEKKDLPDG--R 18343

Query: 1773  IVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAK----TFTYGPEIEANVTTGPGEGAPGPP 1828
              +             V  L E   Y FR+ A+     F+   +    +T      AP   
Sbjct: 18344 WMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITARDEIDAPNAS 18403

Query: 1829  GVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMD 1888
               P   +Y   I +H  +G+        +V+EA    + + D++     KE+      M+
Sbjct: 18404 LDP---KYKDVIVVH--AGE-------TFVLEADIRGKPIPDVVWSKDGKELEETAARME 18451

Query: 1889  I 1889
             I
Sbjct: 18452 I 18452



 Score =  139 bits (350), Expect = 3e-32
 Identities = 336/1554 (21%), Positives = 565/1554 (36%), Gaps = 218/1554 (14%)

Query: 378   FQCFARNAAGEVQ---TSTYLAVTSIAPN----ITRGPLDSTVID-GMSVVLACETSGAP 429
             F+  A N AGE +   T+  +  T I       I  G  D  V   G  + +     G P
Sbjct: 9474  FRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGRP 9533

Query: 430   RPAITWQ---KGERILASGSVQLPRFTPLE----SGSLLISPTHISDAGTYTCLATNSRG 482
              P  +W+   K ++ +  G   +P    LE    S  ++I     S  G Y+  A N  G
Sbjct: 9534  TPKSSWEFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNKAG 9593

Query: 483   VDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVT-----HDPRVTIR-YIWEKDGA 536
                A+  + V     +  PP+D  V   T+ S  C ++      D    I+ Y+ EK   
Sbjct: 9594  QKTANCRVKVMD---VPGPPKDLKVSDITRGS--CRLSWKMPDDDGGDRIKGYVIEK--R 9646

Query: 537   TLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRV-----ISAGGNDSRSAHLRVRQLPH 591
             T+  ++  ++  D   +  +      +   Y  RV        G           R   +
Sbjct: 9647  TIDGKAWTKVNPDCGSTTFVVPDLLSE-QQYFFRVRAENRFGIGPPVETIQRTTARDPIY 9705

Query: 592   APEHPVAT-LSTVERRAINLTWTKPF-DGNSPLIRYILEMSENNAPWTVLLA-----SVD 644
              P+ P+   +  + +  ++L+W  P  DG SP+  YI+E    +   T   A       D
Sbjct: 9706  PPDPPIKLKIGLITKNTVHLSWKPPKNDGGSPVTHYIVECLAWDPTGTKKEAWRQCNKRD 9765

Query: 645   PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSK-----DTERVSLPE--------EPPT 691
              +    TV+ LV    Y+FR+ AVN  G  + S      D +R  +P         E   
Sbjct: 9766  VEELQFTVEDLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEE 9825

Query: 692   APPQNVIASGRTNQSIMIQW-QPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVN 750
                 N++A  +      + W + PP+   N               PV Y      D  VN
Sbjct: 9826  GTNVNIVAKIKGVPFPTLTWFKAPPKKPDNKE-------------PVLY------DTHVN 9866

Query: 751   NLLLED---LIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQ--GVPTVPPGNVHAEATNS 805
              L+++D   L+I  +   +   Y    +    +   E  L   G P  P G +  E+ ++
Sbjct: 9867  KLVVDDTCTLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSA 9926

Query: 806   TTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFT 865
               +  +W  P        + G K+  +  E+ E         + +       +  L +  
Sbjct: 9927  DQMTLSWFPPKD------DGGSKITNYVIEKREANRKTWVHVSSEPKECTYTIPKLLEGH 9980

Query: 866   EYFTSVLCFTTPGDGPR--STPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG 923
             EY   ++     G G    S P+  R    VPG     + S +   S+ V+W+EP    G
Sbjct: 9981  EYVFRIMAQNKYGIGEPLDSEPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGG 10040

Query: 924   I-LTGYRIS--------WEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSK 974
               +TGY +         W+  NR   +       + + Y+VTGL   + Y   V A+ + 
Sbjct: 10041 SPVTGYWLEMKDTTSKRWKRVNRDPIKAM----TLGVSYKVTGLIEGSDYQFRVYAINAA 10096

Query: 975   GQGQVS--ASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGY-DGKTSISRWLVEAQ 1031
             G G  S  +   ++  P   PGPP    +++    S  L++ P   DG + ++ ++VE +
Sbjct: 10097 GVGPASLPSDPATARDPIAPPGPPFP-KVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYK 10155

Query: 1032  VGVVGEG-EEWLLIHQLSNEPDAR--SMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRK 1088
                  EG EEW    +   + + R   + V  L     Y FR+R VNI G   P + +  
Sbjct: 10156 ----EEGKEEW----EKGKDKEVRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDV 10207

Query: 1089  IQ---TLQAPPDMAPANVSLRTASETS------LWLRWMPLPEMEYNGNPESVGYKIKYS 1139
             I+    L +P     A+V  R             ++   P P + +N N  ++  +    
Sbjct: 10208 IEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQE---- 10263

Query: 1140  RSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVP 1199
                      + +    +     I++ +   +    + A N   +G   +T++    + VP
Sbjct: 10264 ---------ATIETTAISSSMVIKNCQRSHQGVYSLLAKNE--AGERKKTIIVDVLD-VP 10311

Query: 1200  SSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFW--LVEGNS 1257
                 T   A   T+ S  + W   PE D    +  Y +  +E D     R W  +    +
Sbjct: 10312 GPVGTPFLAHNLTNESCKLTWFS-PEDDGGSPITNYVIEKRESDR----RAWTPVTYTVT 10366

Query: 1258  SRSAQLTGLGKYVLYEVQVLAFTRIGDGS--PSHPPILERTLDDVPGPPMGILFPEVRTT 1315
              ++A + GL +   Y  ++ A   IG G    +   ++ R    VP  P  +   EV   
Sbjct: 10367 RQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLEVKEVTKN 10426

Query: 1316  SVRLIWQPPAAPNGI-ILAYQITHRL-NTTTANTATVEVLAPSARQYTATGLKPESVYLF 1373
             +V L W PP    G  I+ Y +  RL  T   +  T + L   +R+YT  GLK    Y +
Sbjct: 10427 TVTLTWNPPKYDGGSEIINYVLESRLIGTEKFHKVTNDNLL--SRKYTVKGLKEGDTYEY 10484

Query: 1374  RITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR 1433
             R++A    G G+ +      T K D   PP+  +    D R +   L+   G       R
Sbjct: 10485 RVSAVNIVGQGKPSFCTKPITCK-DELAPPTLHL----DFRDK---LTIRVGEAFALTGR 10536

Query: 1434  YYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATND------IGDSEF 1487
             Y     +  P   W    A V  +  + I          K + K ++       + +S  
Sbjct: 10537 Y---SGKPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTG 10593

Query: 1488  SEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYE 1547
             S +      +   P      +S    T   ++I W+PP +D     +  + I  +E+  +
Sbjct: 10594 SRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPPLDDG-GSKITNYIIEKKEVGKD 10652

Query: 1548  GLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGE 1607
                             W  +T        S  + T  ++  L + + Y  R+   N  G 
Sbjct: 10653 ---------------VWMPVT--------SASAKTTCKVSKLLEGKDYIFRIHAENLYGI 10689

Query: 1608  GPSSPPQEVFVGE--AVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWE 1665
                     +   +   VP  AP   +V   T     VTW  P        I  Y +   E
Sbjct: 10690 SDPLVSDSMKAKDRFRVPD-APDQPIVTEVTKDSALVTWNKP--HDGGKPITNYILEKRE 10746

Query: 1666  AQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDG---PRSTPTQGQTQQA 1722
                       K         ++ +L     Y   V+A N  G G   P S P   +   A
Sbjct: 10747 TMSKRWARVTKDPIHPYTKFRVPDLLEGCQYEFRVSAENEIGIGDPSPPSKPVFAKDPIA 10806

Query: 1723  APSAPSSVKFSELTTTSVNVSWEAPQFPNGI-LEGYRLVYEPCSPVDGVSKIVTVDVKGN 1781
              PS P + +  + T  SV+++W+ P+   G  + GY + Y+     D   +      +  
Sbjct: 10807 KPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEYQKVG--DEEWRRANHTPESC 10864

Query: 1782  SPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVR 1835
                  KV  L +G TY+FR+ A                 GE  P     P++V+
Sbjct: 10865 PETKYKVTGLRDGQTYKFRVLA-------------VNAAGESDPAHVPEPVLVK 10905



 Score =  138 bits (347), Expect = 7e-32
 Identities = 278/1273 (21%), Positives = 477/1273 (37%), Gaps = 148/1273 (11%)

Query: 693   PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNI-TDADVNN 751
             PPQ++     T  S+ + W PP     + I K YI+    +       +  + T+    +
Sbjct: 15649 PPQDLKVKEVTKTSVTLTWDPPLLDGGSKI-KNYIVEKRESTRKA---YSTVATNCHKTS 15704

Query: 752   LLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFT 811
               ++ L    +Y   V A N  G+G+  ++  E        +PPG +        ++  +
Sbjct: 15705 WKVDQLQEGCSYYFRVLAENEYGIGL-PAETAESVKASERPLPPGKITLMDVTRNSVSLS 15763

Query: 812   WNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSV 871
             W  P     + I  GY +       ++  T  T +      +    ++GL +  EY   V
Sbjct: 15764 WEKPEHDGGSRI-LGYIVEMQTKGSDKWATCATVK------VTEATITGLIQGEEYSFRV 15816

Query: 872   LCFTTPG-DGPRSTPQLVRTHEDVPGPVGHL---SFSEILDTSLKVSWQEPGEKNGILTG 927
                   G   PR     V   + V  P   L   +F+ +    LKV     G     +T 
Sbjct: 15817 SAQNEKGISDPRQLSVPVIAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTW 15876

Query: 928   YR--ISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTIS 985
             ++  +  ++  R N   T    N  L  +      +  Y +++    S G+   + + I 
Sbjct: 15877 HKDNVPLKQTTRVNAESTEN--NSLLTIKDACREDVGHYVVKLT--NSAGEAIETLNVIV 15932

Query: 986   SGVPPELPGPPTN-LGISNIGPRSVTLQFRPG-YDGKTSISRWLVEAQVGVVGEGEEWLL 1043
                  + PGPPT  + +  +   S+TL + P  YDG +SI+ ++VE +       +    
Sbjct: 15933 L----DKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSINNYIVEKR-------DTSTT 15981

Query: 1044  IHQLSNEPDARS-MEVPDLNPFTCYSFRMRQVNIVGTSP--PSQPSRKIQTLQAPPDMAP 1100
               Q+ +   AR+ ++   L     Y FR+   N  G S    S+P+      + P     
Sbjct: 15982 TWQIVSATVARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTVAQYPFKVPGPPGT 16041

Query: 1101  ANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRV---E 1157
               V+L  +S  S+ ++W    E   +G    +GY ++    +    ++  V  ++    +
Sbjct: 16042 PVVTL--SSRDSMEVQWN---EPISDGGSRVIGYHLERKERN----SILWVKLNKTPIPQ 16092

Query: 1158  RDYTIEDLEEWTEYRVQVQAFNAIGSGP---WSQTVVGRTRESVPSSGPTNVSALATTSS 1214
               +    LEE  EY  +V A N +G G     S+  V R     P   P    A+  T +
Sbjct: 16093 TKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARD----PCDPPGRPEAIIVTRN 16148

Query: 1215  SMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSA---------QLTG 1265
             S+ ++W + P  D    + GY V  KE          L EG   +++         ++TG
Sbjct: 16149 SVTLQWKK-PTYDGGSKITGYIVEKKE----------LPEGRWMKASFTNIIDTHFEVTG 16197

Query: 1266  LGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLI---WQ 1322
             L +   YE +V+A    G  S         T  D   PP   + P+ + T V      ++
Sbjct: 16198 LVEDHRYEFRVIARNAAGVFSEPSESTGAITARDEVDPPRISMDPKYKDTIVVHAGESFK 16257

Query: 1323  PPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKG 1382
               A   G  +      + +   +NTA +E+ +       AT L  +            K 
Sbjct: 16258 VDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDF----ATSLSVKDAVRVDSGNYILKA 16313

Query: 1383  WGEAAE-ALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTR 1440
                A E ++ V  +  DRP PP  P+V    V A    L+W+P   DG S +  Y ++ R
Sbjct: 16314 KNVAGERSVTVNVKVLDRPGPPEGPVVIS-GVTAEKCTLAWKPPLQDGGSDIINYIVERR 16372

Query: 1441  ELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAA 1500
             E     W +  A+V     S  V +L     Y FR+ A N  G  E  E    +      
Sbjct: 16373 ETSRLVWTVVDANVQ--TLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLESEPVVAKNPFV 16430

Query: 1501  PDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNP 1560
               +AP    VT  T  S+++ W+ PA D  + IL                G+ L   +  
Sbjct: 16431 VPDAPKAPEVTTVTKDSMIVVWERPASDGGSEIL----------------GYVLEKRDKE 16474

Query: 1561  GATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQ--EVFV 1618
             G  W         R +    L    +  L ++  YE R+S  NA G    SPP   +   
Sbjct: 16475 GIRWTRC----HKRLIGELRL---RVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKAC 16527

Query: 1619  GEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTL 1678
                     P N  V   T + + ++W  P  D    +IQGY +   +   G  T      
Sbjct: 16528 DPIYKPGPPNNPKVIDITRSSVFLSWSKPIYDG-GCEIQGYIVEKCDVSVGEWTMCTPPT 16586

Query: 1679  FLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTT 1738
              + + +++++ L     Y   + A N AG G          + A    P  V+  +L   
Sbjct: 16587 GINKTNIEVEKLLEKHEYNFRICAINKAGVG----------EHADVPGPIIVE-EKLEAP 16635

Query: 1739  SVNVSWEAPQFPNGILEGYRLVYEPC----------SPVDG-VSKIVTVDVKGN-SPLWL 1786
              +++  E  +  N    G   ++ P             VDG +     +DV  + + L L
Sbjct: 16636 DIDLDLELRKIINIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVL 16695

Query: 1787  KVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSS 1846
                +  +   Y   +   + T    +   V   P      P  + +      +++I W  
Sbjct: 16696 DNVNRYDSGKYTLTLENSSGTKSAFVTVRVLDTPSP----PVNLKVTEITKDSVSITWEP 16751

Query: 1847  G-DPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVND 1905
                 G   I  Y++E R +    +  ++ +  K     ++ +D L+ G SY FRV A N+
Sbjct: 16752 PLLDGGSKIKNYIVEKREATRKSYAAVVTNCHKN----SWKIDQLQEGCSYYFRVTAENE 16807

Query: 1906  YGFGTPSSPSQSV 1918
             YG G P+  +  +
Sbjct: 16808 YGIGLPAQTADPI 16820



 Score =  130 bits (326), Expect = 2e-29
 Identities = 330/1569 (21%), Positives = 558/1569 (35%), Gaps = 197/1569 (12%)

Query: 222   KNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGV-LLSGGISDHNRR---LTIPNPTGS 277
             K  ++ AG S   +  V+   P +   I W K G+ L S  I D       L +      
Sbjct: 23149 KTVTIRAGASLRLMVSVSGRPPPV---ITWSKQGIDLASRAIIDTTESYSLLIVDKVNRY 23205

Query: 278   DAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVV-DIPCQAKGVP 336
             DAG Y  EA  +S    + V         P   VK  E  ++ +   +  +IP    G P
Sbjct: 23206 DAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKE--VSRDSVTITWEIPTIDGGAP 23263

Query: 337   PPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLA 396
               +    K  A +   K T   + +    +ISGLV      F+    N  G  +      
Sbjct: 23264 VNNYIVEKREAAMRAFK-TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEPCE--- 23319

Query: 397   VTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILA-------SGSVQL 449
              TS A  ++  PL    ++ + V  +  T    +P   +  G R+         +G+ + 
Sbjct: 23320 -TSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPL--YDGGSRLTGYVLEACKAGTERW 23376

Query: 450   PRFTPLESGSLLISPTHISDAGTYT--CLATNSRGVDEASA--------DLVVWARTRIT 499
              +   L+   L  + T +++   Y     A N +GV E           DL V     ++
Sbjct: 23377 MKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLS 23436

Query: 500   KPPQDQ-SVIKGTQASMVCGVTHDPRVTIRYIWE----KDGATLGTESHPRIRLDRNGSL 554
               PQ    V  G    +V  +   P     + +     ++   +  E+H ++       L
Sbjct: 23437 TMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKV-----AKL 23491

Query: 555   HISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTK 614
              I +T   D G YT  + +  G  S +  + +   P  P  P+  +  ++  +I ++W  
Sbjct: 23492 TIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIK-IDEIDATSITISWEP 23550

Query: 615   P-FDGNSPLIRYILEMSENNAP-WTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVG 672
             P  DG +PL  Y++E  + + P W  +  SV       T   L     Y FR+ A N  G
Sbjct: 23551 PELDGGAPLSGYVVEQRDAHRPGWLPVSESVTRSTFKFT--RLTEGNEYVFRVAATNRFG 23608

Query: 673   KGQFSKDT-----ERVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYI 727
              G + +         + +P  P T    +V   G T     + W PP E      + GYI
Sbjct: 23609 IGSYLQSEVIECRSSIRIPGPPETLQIFDVSRDGMT-----LTWYPP-EDDGGSQVTGYI 23662

Query: 728   IRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTL 787
             +           +   +    +       L     YE  V A N+ G G   S+ ++  +
Sbjct: 23663 VERKEVRADRWVRVNKVP-VTMTRYRSTGLTEGLEYEHRVTAINARGSGK-PSRPSKPIV 23720

Query: 788   QGVPTVPPG---NVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVT 844
                P  PPG   N     T  T++   W+ P  +  + +  GY LI  +   + E T   
Sbjct: 23721 AMDPIAPPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVT-GY-LIEMQKVDQHEWTKCN 23778

Query: 845   ARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFS 904
               P     I    ++ L +  EY   VL     G G  +         +VPG V      
Sbjct: 23779 TTPT---KIREYTLTHLPQGAEYRFRVLACNAGGPGEPA---------EVPGTVKVTEML 23826

Query: 905   EILDTSLKVSWQE----------------PGEKNGILTGYRISWEEYNRTNTRVTHYLPN 948
             E  D  L   +QE                 G+   I    +   +   R     +     
Sbjct: 23827 EYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTE 23886

Query: 949   VTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRS 1008
             + ++    G +   TY + +     K    +    I S   PE P     L   +I  RS
Sbjct: 23887 LVIKEADRGDSG--TYDLVLENKCGKKAVYIKVRVIGSPNSPEGP-----LEYDDIQVRS 23939

Query: 1009  VTLQFRP-GYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCY 1067
             V + +RP   DG   I  +++E +         W   + + +     S+ V  L     Y
Sbjct: 23940 VRVSWRPPADDGGADILGYILERREVPKAA---W---YTIDSRVRGTSLVVKGLKENVEY 23993

Query: 1068  SFRMRQVNIVGTSPPSQPSRKI--QTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEY 1125
              FR+   N  G S P +    +  +T   PP+       +   +++S+ L W    +   
Sbjct: 23994 HFRVSAENQFGISKPLKSEEPVTPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKD--- 24050

Query: 1126  NGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIG--- 1182
             +G     GY I+  +     K + H         YT+  L    EY+ ++ A N +G   
Sbjct: 24051 DGGSRVTGYYIE-RKETSTDKWVRHNKTQITTTMYT