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Search of human proteins with 222144290
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222144290 fibronectin type III domain containing 7 [Homo
sapiens]
(733 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222144290 fibronectin type III domain containing 7 [Homo sapi... 1488 0.0
gi|47132557 fibronectin 1 isoform 1 preproprotein [Homo sapiens] 78 3e-14
gi|47132551 fibronectin 1 isoform 2 preproprotein [Homo sapiens] 78 3e-14
gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens] 76 1e-13
gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens] 76 1e-13
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens] 72 1e-12
gi|16933542 fibronectin 1 isoform 3 preproprotein [Homo sapiens] 72 2e-12
gi|47132555 fibronectin 1 isoform 4 preproprotein [Homo sapiens] 72 2e-12
gi|157384973 tenascin R [Homo sapiens] 65 2e-10
gi|62988324 tenascin N [Homo sapiens] 65 3e-10
gi|241896924 protein tyrosine phosphatase, receptor type, H isof... 64 4e-10
gi|205360934 fibronectin type III domain containing 3B [Homo sap... 61 4e-09
gi|205360932 fibronectin type III domain containing 3B [Homo sap... 61 4e-09
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 59 2e-08
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 59 2e-08
gi|112734845 collagen, type XX, alpha 1 [Homo sapiens] 54 4e-07
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 54 5e-07
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 54 5e-07
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 54 7e-07
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 54 7e-07
gi|241896926 protein tyrosine phosphatase, receptor type, H isof... 53 1e-06
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 52 2e-06
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 52 2e-06
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 50 6e-06
gi|110349719 titin isoform N2-A [Homo sapiens] 50 7e-06
gi|110349717 titin isoform novex-2 [Homo sapiens] 50 7e-06
gi|110349713 titin isoform novex-1 [Homo sapiens] 50 7e-06
gi|110349715 titin isoform N2-B [Homo sapiens] 50 7e-06
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 49 1e-05
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 49 2e-05
>gi|222144290 fibronectin type III domain containing 7 [Homo
sapiens]
Length = 733
Score = 1488 bits (3853), Expect = 0.0
Identities = 733/733 (100%), Positives = 733/733 (100%)
Query: 1 MAGGRETCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLL 60
MAGGRETCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLL
Sbjct: 1 MAGGRETCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLL 60
Query: 61 TAEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILE 120
TAEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILE
Sbjct: 61 TAEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILE 120
Query: 121 VSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKA 180
VSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKA
Sbjct: 121 VSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKA 180
Query: 181 YAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSS 240
YAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSS
Sbjct: 181 YAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSS 240
Query: 241 ELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPP 300
ELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPP
Sbjct: 241 ELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPP 300
Query: 301 GHLSVAWSSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQS 360
GHLSVAWSSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQS
Sbjct: 301 GHLSVAWSSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQS 360
Query: 361 PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVECNDTTPA 420
PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVECNDTTPA
Sbjct: 361 PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVECNDTTPA 420
Query: 421 CTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRS 480
CTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRS
Sbjct: 421 CTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRS 480
Query: 481 TNDDATYTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLE 540
TNDDATYTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLE
Sbjct: 481 TNDDATYTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLE 540
Query: 541 TVPCCPTGLTVTQITQSVINVSWTIGRVAQTHVAVLESHTGQSKCHTHQNHCLLGCITCG 600
TVPCCPTGLTVTQITQSVINVSWTIGRVAQTHVAVLESHTGQSKCHTHQNHCLLGCITCG
Sbjct: 541 TVPCCPTGLTVTQITQSVINVSWTIGRVAQTHVAVLESHTGQSKCHTHQNHCLLGCITCG 600
Query: 601 INYTVTLKAISATGLTADCSYQSYFSGACCPLGVKLYRLGPNGIRIYWQASRGSANYSTD 660
INYTVTLKAISATGLTADCSYQSYFSGACCPLGVKLYRLGPNGIRIYWQASRGSANYSTD
Sbjct: 601 INYTVTLKAISATGLTADCSYQSYFSGACCPLGVKLYRLGPNGIRIYWQASRGSANYSTD 660
Query: 661 LYGSKGIFTCTPSAGLSFCDVTEIPCGDVYTVMVSPVAKTGLKLTFCPKKIYSVTCSGST 720
LYGSKGIFTCTPSAGLSFCDVTEIPCGDVYTVMVSPVAKTGLKLTFCPKKIYSVTCSGST
Sbjct: 661 LYGSKGIFTCTPSAGLSFCDVTEIPCGDVYTVMVSPVAKTGLKLTFCPKKIYSVTCSGST 720
Query: 721 LGMVIYRGKRNEE 733
LGMVIYRGKRNEE
Sbjct: 721 LGMVIYRGKRNEE 733
>gi|47132557 fibronectin 1 isoform 1 preproprotein [Homo sapiens]
Length = 2477
Score = 77.8 bits (190), Expect = 3e-14
Identities = 136/591 (23%), Positives = 237/591 (40%), Gaps = 62/591 (10%)
Query: 29 PEIPTI-DQAYSKLSNS-ITVEW-----ATVPGATSYLLTAEDGDTVIETTVANSPG--T 79
PE+P + D ++ +++S I + W +T+ G ++ A +G + E V +S G T
Sbjct: 1265 PEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYT 1324
Query: 80 VTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMA 139
VTGL+ Y+I++ ++ G S + Q V L ++ D++ V W A +
Sbjct: 1325 VTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTW-APPPS 1383
Query: 140 IAFSVSIMRANGLGSIWKENTTNTSLT-------FTSLEAGTLYTIKAYAWNANRIPGDD 192
I + ++R + + + +E+ S++ T+L GT Y + ++ +
Sbjct: 1384 IDLTNFLVRYSPVKN--EEDVAELSISPSDNAVVLTNLLPGTEYVVSV----SSVYEQHE 1437
Query: 193 STC---NQRTSPRAPANIQVSFDSGALKASFSWARAEGAFN-YTVMALSDS-----SELT 243
ST Q+T +P I S D A + W Y + + E
Sbjct: 1438 STPLRGRQKTGLDSPTGIDFS-DITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDR 1496
Query: 244 CSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHL 303
+ +S T+++L GTEY++S++A N S TV+ P + + P L
Sbjct: 1497 VPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQ-STVSDVPRDLEVVAATPTSL 1555
Query: 304 SVAWSSVDLGDYYVVFVKSDDG-------LEVHCNTSLTQCNFLSECGFTYFISVFVYNK 356
++W + + Y + G V + S + L G Y I+V+
Sbjct: 1556 LISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP-GVDYTITVYAVTG 1614
Query: 357 AGQSPLGD---IFNYTTAPCCPSDINPVLVSSDRVEIVW----SPVRGAELYETKAVDGY 409
G SP NY T PS + V + + + W SPV G + T +G
Sbjct: 1615 RGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPK-NGP 1673
Query: 410 NMVECNDTTP---ACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNV 466
+ P T+ L+ +Y ++VY+ N G + +T +
Sbjct: 1674 GPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNP-SGESQPLVQTAVTNIDRPKGLAFT 1732
Query: 467 SRDAFSMINVHWRSTNDDAT-YTVT-AQGEKGLYQC--SSTGESCT--MRGLPCGSVFSV 520
D S I + W S + Y VT + E G+++ + GE T ++GL GS ++V
Sbjct: 1733 DVDVDS-IKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTV 1791
Query: 521 TAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQT 571
+ VA S P +P PT L TQ+T + ++ WT V T
Sbjct: 1792 SVVALHDDMESQPLIGTQSTAIPA-PTDLKFTQVTPTSLSAQWTPPNVQLT 1841
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/562 (22%), Positives = 207/562 (36%), Gaps = 49/562 (8%)
Query: 42 SNSITVEW----ATVPGATSYLLTAEDGDTVIETTVANSPG--TVTGLKAATWYEITIRS 95
+NS TV W AT+ G E V +S T+T L T Y ++I +
Sbjct: 1462 ANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVA 1521
Query: 96 ISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
++ S +Q+ LEV + + S+L+ W+A + + + G S
Sbjct: 1522 LNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSP 1581
Query: 156 WKENT---TNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDS------TCNQRTSPRAPAN 206
+E T + ++ T + L+ G YTI YA GD + N RT P+
Sbjct: 1582 VQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR---GDSPASSKPISINYRTEIDKPSQ 1638
Query: 207 IQVSFDSGALKASFSWARAEG-AFNYTVMAL-----SDSSELTCSTTFSSCTISSLQCGT 260
+QV+ D S W + Y V + T + TI LQ
Sbjct: 1639 MQVT-DVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV 1697
Query: 261 EYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSV--DLGDYYVV 318
EY++SV A N +G S+ T T P + + + +AW S + Y V
Sbjct: 1698 EYVVSVYAQNPSGESQ-PLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVT 1756
Query: 319 FVKSDDGLE-----VHCNTSLTQCNFLSECGFTYFISVF-VYNKAGQSPLGDIFNYTTAP 372
+ +DG+ + L G Y +SV +++ PL I +TA
Sbjct: 1757 YSSPEDGIHELFPAPDGEEDTAELQGLRP-GSEYTVSVVALHDDMESQPL--IGTQSTAI 1813
Query: 373 CCPSDINPVLVSSDRVEIVWSP----VRGAELYETKAVDGYNMVECN--DTTPACTLSAL 426
P+D+ V+ + W+P + G + T M E N + + +S L
Sbjct: 1814 PAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGL 1873
Query: 427 ECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT 486
TKY ++VY+ + S + P V+ + I + WR+ + T
Sbjct: 1874 MVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETIT 1933
Query: 487 ----YTVTAQGEKGLYQCSSTG-ESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLET 541
V A G+ + + S T+ GL G+ + + RS P + T
Sbjct: 1934 GFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSP-VVIDAST 1992
Query: 542 VPCCPTGLTVTQITQSVINVSW 563
P+ L T + + VSW
Sbjct: 1993 AIDAPSNLRFLATTPNSLLVSW 2014
Score = 60.5 bits (145), Expect = 6e-09
Identities = 137/675 (20%), Positives = 248/675 (36%), Gaps = 65/675 (9%)
Query: 75 NSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQW- 133
N+ VTGL Y + ++S S+ +Q + A L+ + + ++LV+W
Sbjct: 959 NTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWT 1018
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGD 191
A +V + R G + + + +L+ + YT+ A N+
Sbjct: 1019 PPRAQITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK 1077
Query: 192 DS---TCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT- 247
+ T Q S P N +V+ + + +W A + S E T
Sbjct: 1078 ATGVFTTLQPGSSIPPYNTEVTETTIVI----TWTPAPRIGFKLGVRPSQGGEAPREVTS 1133
Query: 248 -FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDP-PGHLSV 305
S +S L G EY+ ++ D + + T P + ++ +P G L+V
Sbjct: 1134 DSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTV 1193
Query: 306 AW---SSVDLGDYYVVFVKSD----DGLEVHCNTSLTQCNFLS-ECGFTYFISVFVYNKA 357
+W ++ D+ Y + ++ + LE + + C F + G Y +SV+
Sbjct: 1194 SWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Query: 358 GQS-PLGDIFNYTTAPCCP--SDINPVLVSSDRVEIVWSPVR-----GAELYETKAVDGY 409
+S P+ D T P P +D++ V ++ + + W+P+ G + A +G
Sbjct: 1254 KESVPISD----TIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGI 1309
Query: 410 NMVE--CNDTTPACTLSALECDTKYNITVYS-FNEVRGSNMSCTPQFITTAPCSPEIKNV 466
+ E + + T++ LE Y+I+V + N + + T Q P N+
Sbjct: 1310 PIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNI 1369
Query: 467 SRDAFSMINVHWRS------TNDDATYT-VTAQGEKGLYQCSSTGESCTMRGLPCGS--V 517
D + V W TN Y+ V + + S + + + L G+ V
Sbjct: 1370 GPDT---MRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYV 1426
Query: 518 FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQT------ 571
SV++V E L +T PTG+ + IT + V W R T
Sbjct: 1427 VSVSSVYEQHESTPLRGRQ---KTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRH 1483
Query: 572 HVAVLESHTGQSKCHTHQNHCLLGCITCGINYTVTLKAISATGLT-ADCSYQSYFSGACC 630
H + + +N L +T G Y V++ A++ + QS S
Sbjct: 1484 HPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV-- 1541
Query: 631 PLGVKLYRLGPNGIRIYWQASRGSANYSTDLYGSKG----IFTCTPSAGLSFCDVTEIPC 686
P +++ P + I W A + Y YG G + T S ++ +
Sbjct: 1542 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1601
Query: 687 GDVYTVMVSPVAKTG 701
G YT+ V V G
Sbjct: 1602 GVDYTITVYAVTGRG 1616
Score = 56.2 bits (134), Expect = 1e-07
Identities = 90/374 (24%), Positives = 140/374 (37%), Gaps = 47/374 (12%)
Query: 241 ELTCSTTFSSCTISSLQCGTEY---LISV------------LASNDAGSSKSSSAMTLKT 285
E T +S TI L+ G Y LIS+ + + +S+ +T +T
Sbjct: 656 EATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET 715
Query: 286 VACAPGRVT---IQEDPPGHLSVAWSSVD--LGDYYVVFVKSDDGLE---VHCNTSLTQC 337
+P T + E V+W S + + V + S++G E + ++ T
Sbjct: 716 TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSV 775
Query: 338 NFLSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWS--- 393
N G Y ++V+ ++ G+ L + TTAP P D V + + WS
Sbjct: 776 NIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQ 835
Query: 394 -PVRGAELYETKAVDGYNMVECN--DTTPACTLSALECDTKYNITVYSFNEVRGSNMSCT 450
P+ G + + +V+G + E N +T + TLS L+ +YNIT+Y+ E + S
Sbjct: 836 APITGYRIVYSPSVEG-SSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVI 894
Query: 451 PQFITTAPCSPEIKNVSRDAF-----SMINVHWRSTNDDAT------YTVTAQGEKGLYQ 499
Q T P S + + F + + W T V GE G
Sbjct: 895 QQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRL 954
Query: 500 CSSTGESCTMRGLPCGSV--FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQS 557
S + GL G F V AV+ GR + T PT L T S
Sbjct: 955 PISRNTFAEVTGLSPGVTYYFKVFAVSH---GRESKPLTAQQTTKLDAPTNLQFVNETDS 1011
Query: 558 VINVSWTIGRVAQT 571
+ V WT R T
Sbjct: 1012 TVLVRWTPPRAQIT 1025
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/462 (21%), Positives = 167/462 (36%), Gaps = 54/462 (11%)
Query: 21 MVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLLTAEDGDT-----VIETTV-- 73
++ + ++P + + S+ + W P T G+T V E TV
Sbjct: 1531 LIGQQSTVSDVPRDLEVVAATPTSLLISW-DAPAVTVRYYRITYGETGGNSPVQEFTVPG 1589
Query: 74 ANSPGTVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAPI-LEVSSPSSDSI 129
+ S T++GLK Y IT+ +++ G S AS +T + P ++V+ +SI
Sbjct: 1590 SKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSI 1649
Query: 130 LVQW-EAVYMAIAFSVSIMRANGLGSIWKENT--TNTSLTFTSLEAGTLYTIKAYAWN-- 184
V+W + + V+ NG G + T +T L+ Y + YA N
Sbjct: 1650 SVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPS 1709
Query: 185 ANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFN-YTVMALSDSSEL- 242
P + P+ A V DS +W +G + Y V S +
Sbjct: 1710 GESQPLVQTAVTNIDRPKGLAFTDVDVDS----IKIAWESPQGQVSRYRVTYSSPEDGIH 1765
Query: 243 ----TCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQED 298
+ + L+ G+EY +SV+A +D S+ T T AP + +
Sbjct: 1766 ELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIG-TQSTAIPAPTDLKFTQV 1824
Query: 299 PPGHLSVAWS--SVDLGDYYV-VFVKSDDGLEVHCNTSLTQCNFLSE---CGFTYFISVF 352
P LS W+ +V L Y V V K G N + + + Y +SV+
Sbjct: 1825 TPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVY 1884
Query: 353 VYNKAGQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNM 411
S P + P + + I W +T+ + G+ +
Sbjct: 1885 ALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRT-------KTETITGFQV 1937
Query: 412 --VECNDTTP----------ACTLSALECDTKYNITVYSFNE 441
V N TP + T++ L+ T Y I +Y+ N+
Sbjct: 1938 DAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1979
Score = 39.7 bits (91), Expect = 0.010
Identities = 42/154 (27%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 44 SITVEWAT-VPGATSYLLTA--EDGDTVIETTVANSPG--TVTGLKAATWYEITIRSISA 98
+IT+ W T T + + A +G T I+ T+ T+TGL+ T Y+I + +++
Sbjct: 1920 TITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1979
Query: 99 AGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKE 158
RS + + A L + + +S+LV W+ I + I++ GS +E
Sbjct: 1980 NARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARI--TGYIIKYEKPGSPPRE 2037
Query: 159 NTTN-----TSLTFTSLEAGTLYTIKAYAWNANR 187
T T T LE GT YTI A N+
Sbjct: 2038 VVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
>gi|47132551 fibronectin 1 isoform 2 preproprotein [Homo sapiens]
Length = 2421
Score = 77.8 bits (190), Expect = 3e-14
Identities = 136/591 (23%), Positives = 237/591 (40%), Gaps = 62/591 (10%)
Query: 29 PEIPTI-DQAYSKLSNS-ITVEW-----ATVPGATSYLLTAEDGDTVIETTVANSPG--T 79
PE+P + D ++ +++S I + W +T+ G ++ A +G + E V +S G T
Sbjct: 1265 PEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYT 1324
Query: 80 VTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMA 139
VTGL+ Y+I++ ++ G S + Q V L ++ D++ V W A +
Sbjct: 1325 VTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTW-APPPS 1383
Query: 140 IAFSVSIMRANGLGSIWKENTTNTSLT-------FTSLEAGTLYTIKAYAWNANRIPGDD 192
I + ++R + + + +E+ S++ T+L GT Y + ++ +
Sbjct: 1384 IDLTNFLVRYSPVKN--EEDVAELSISPSDNAVVLTNLLPGTEYVVSV----SSVYEQHE 1437
Query: 193 STC---NQRTSPRAPANIQVSFDSGALKASFSWARAEGAFN-YTVMALSDS-----SELT 243
ST Q+T +P I S D A + W Y + + E
Sbjct: 1438 STPLRGRQKTGLDSPTGIDFS-DITANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDR 1496
Query: 244 CSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHL 303
+ +S T+++L GTEY++S++A N S TV+ P + + P L
Sbjct: 1497 VPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQ-STVSDVPRDLEVVAATPTSL 1555
Query: 304 SVAWSSVDLGDYYVVFVKSDDG-------LEVHCNTSLTQCNFLSECGFTYFISVFVYNK 356
++W + + Y + G V + S + L G Y I+V+
Sbjct: 1556 LISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP-GVDYTITVYAVTG 1614
Query: 357 AGQSPLGD---IFNYTTAPCCPSDINPVLVSSDRVEIVW----SPVRGAELYETKAVDGY 409
G SP NY T PS + V + + + W SPV G + T +G
Sbjct: 1615 RGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPK-NGP 1673
Query: 410 NMVECNDTTP---ACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNV 466
+ P T+ L+ +Y ++VY+ N G + +T +
Sbjct: 1674 GPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNP-SGESQPLVQTAVTNIDRPKGLAFT 1732
Query: 467 SRDAFSMINVHWRSTNDDAT-YTVT-AQGEKGLYQC--SSTGESCT--MRGLPCGSVFSV 520
D S I + W S + Y VT + E G+++ + GE T ++GL GS ++V
Sbjct: 1733 DVDVDS-IKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTV 1791
Query: 521 TAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQT 571
+ VA S P +P PT L TQ+T + ++ WT V T
Sbjct: 1792 SVVALHDDMESQPLIGTQSTAIPA-PTDLKFTQVTPTSLSAQWTPPNVQLT 1841
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/562 (22%), Positives = 207/562 (36%), Gaps = 49/562 (8%)
Query: 42 SNSITVEW----ATVPGATSYLLTAEDGDTVIETTVANSPG--TVTGLKAATWYEITIRS 95
+NS TV W AT+ G E V +S T+T L T Y ++I +
Sbjct: 1462 ANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVA 1521
Query: 96 ISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
++ S +Q+ LEV + + S+L+ W+A + + + G S
Sbjct: 1522 LNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSP 1581
Query: 156 WKENT---TNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDS------TCNQRTSPRAPAN 206
+E T + ++ T + L+ G YTI YA GD + N RT P+
Sbjct: 1582 VQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR---GDSPASSKPISINYRTEIDKPSQ 1638
Query: 207 IQVSFDSGALKASFSWARAEG-AFNYTVMAL-----SDSSELTCSTTFSSCTISSLQCGT 260
+QV+ D S W + Y V + T + TI LQ
Sbjct: 1639 MQVT-DVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV 1697
Query: 261 EYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSV--DLGDYYVV 318
EY++SV A N +G S+ T T P + + + +AW S + Y V
Sbjct: 1698 EYVVSVYAQNPSGESQ-PLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVT 1756
Query: 319 FVKSDDGLE-----VHCNTSLTQCNFLSECGFTYFISVF-VYNKAGQSPLGDIFNYTTAP 372
+ +DG+ + L G Y +SV +++ PL I +TA
Sbjct: 1757 YSSPEDGIHELFPAPDGEEDTAELQGLRP-GSEYTVSVVALHDDMESQPL--IGTQSTAI 1813
Query: 373 CCPSDINPVLVSSDRVEIVWSP----VRGAELYETKAVDGYNMVECN--DTTPACTLSAL 426
P+D+ V+ + W+P + G + T M E N + + +S L
Sbjct: 1814 PAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGL 1873
Query: 427 ECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT 486
TKY ++VY+ + S + P V+ + I + WR+ + T
Sbjct: 1874 MVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETIT 1933
Query: 487 ----YTVTAQGEKGLYQCSSTG-ESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLET 541
V A G+ + + S T+ GL G+ + + RS P + T
Sbjct: 1934 GFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSP-VVIDAST 1992
Query: 542 VPCCPTGLTVTQITQSVINVSW 563
P+ L T + + VSW
Sbjct: 1993 AIDAPSNLRFLATTPNSLLVSW 2014
Score = 60.5 bits (145), Expect = 6e-09
Identities = 137/675 (20%), Positives = 248/675 (36%), Gaps = 65/675 (9%)
Query: 75 NSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQW- 133
N+ VTGL Y + ++S S+ +Q + A L+ + + ++LV+W
Sbjct: 959 NTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWT 1018
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGD 191
A +V + R G + + + +L+ + YT+ A N+
Sbjct: 1019 PPRAQITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK 1077
Query: 192 DS---TCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT- 247
+ T Q S P N +V+ + + +W A + S E T
Sbjct: 1078 ATGVFTTLQPGSSIPPYNTEVTETTIVI----TWTPAPRIGFKLGVRPSQGGEAPREVTS 1133
Query: 248 -FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDP-PGHLSV 305
S +S L G EY+ ++ D + + T P + ++ +P G L+V
Sbjct: 1134 DSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTV 1193
Query: 306 AW---SSVDLGDYYVVFVKSD----DGLEVHCNTSLTQCNFLS-ECGFTYFISVFVYNKA 357
+W ++ D+ Y + ++ + LE + + C F + G Y +SV+
Sbjct: 1194 SWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Query: 358 GQS-PLGDIFNYTTAPCCP--SDINPVLVSSDRVEIVWSPVR-----GAELYETKAVDGY 409
+S P+ D T P P +D++ V ++ + + W+P+ G + A +G
Sbjct: 1254 KESVPISD----TIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGI 1309
Query: 410 NMVE--CNDTTPACTLSALECDTKYNITVYS-FNEVRGSNMSCTPQFITTAPCSPEIKNV 466
+ E + + T++ LE Y+I+V + N + + T Q P N+
Sbjct: 1310 PIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNI 1369
Query: 467 SRDAFSMINVHWRS------TNDDATYT-VTAQGEKGLYQCSSTGESCTMRGLPCGS--V 517
D + V W TN Y+ V + + S + + + L G+ V
Sbjct: 1370 GPDT---MRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYV 1426
Query: 518 FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQT------ 571
SV++V E L +T PTG+ + IT + V W R T
Sbjct: 1427 VSVSSVYEQHESTPLRGRQ---KTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRH 1483
Query: 572 HVAVLESHTGQSKCHTHQNHCLLGCITCGINYTVTLKAISATGLT-ADCSYQSYFSGACC 630
H + + +N L +T G Y V++ A++ + QS S
Sbjct: 1484 HPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV-- 1541
Query: 631 PLGVKLYRLGPNGIRIYWQASRGSANYSTDLYGSKG----IFTCTPSAGLSFCDVTEIPC 686
P +++ P + I W A + Y YG G + T S ++ +
Sbjct: 1542 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1601
Query: 687 GDVYTVMVSPVAKTG 701
G YT+ V V G
Sbjct: 1602 GVDYTITVYAVTGRG 1616
Score = 56.2 bits (134), Expect = 1e-07
Identities = 90/374 (24%), Positives = 140/374 (37%), Gaps = 47/374 (12%)
Query: 241 ELTCSTTFSSCTISSLQCGTEY---LISV------------LASNDAGSSKSSSAMTLKT 285
E T +S TI L+ G Y LIS+ + + +S+ +T +T
Sbjct: 656 EATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET 715
Query: 286 VACAPGRVT---IQEDPPGHLSVAWSSVD--LGDYYVVFVKSDDGLE---VHCNTSLTQC 337
+P T + E V+W S + + V + S++G E + ++ T
Sbjct: 716 TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSV 775
Query: 338 NFLSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWS--- 393
N G Y ++V+ ++ G+ L + TTAP P D V + + WS
Sbjct: 776 NIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQ 835
Query: 394 -PVRGAELYETKAVDGYNMVECN--DTTPACTLSALECDTKYNITVYSFNEVRGSNMSCT 450
P+ G + + +V+G + E N +T + TLS L+ +YNIT+Y+ E + S
Sbjct: 836 APITGYRIVYSPSVEG-SSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVI 894
Query: 451 PQFITTAPCSPEIKNVSRDAF-----SMINVHWRSTNDDAT------YTVTAQGEKGLYQ 499
Q T P S + + F + + W T V GE G
Sbjct: 895 QQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRL 954
Query: 500 CSSTGESCTMRGLPCGSV--FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQS 557
S + GL G F V AV+ GR + T PT L T S
Sbjct: 955 PISRNTFAEVTGLSPGVTYYFKVFAVSH---GRESKPLTAQQTTKLDAPTNLQFVNETDS 1011
Query: 558 VINVSWTIGRVAQT 571
+ V WT R T
Sbjct: 1012 TVLVRWTPPRAQIT 1025
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/462 (21%), Positives = 167/462 (36%), Gaps = 54/462 (11%)
Query: 21 MVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLLTAEDGDT-----VIETTV-- 73
++ + ++P + + S+ + W P T G+T V E TV
Sbjct: 1531 LIGQQSTVSDVPRDLEVVAATPTSLLISW-DAPAVTVRYYRITYGETGGNSPVQEFTVPG 1589
Query: 74 ANSPGTVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAPI-LEVSSPSSDSI 129
+ S T++GLK Y IT+ +++ G S AS +T + P ++V+ +SI
Sbjct: 1590 SKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSI 1649
Query: 130 LVQW-EAVYMAIAFSVSIMRANGLGSIWKENT--TNTSLTFTSLEAGTLYTIKAYAWN-- 184
V+W + + V+ NG G + T +T L+ Y + YA N
Sbjct: 1650 SVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPS 1709
Query: 185 ANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFN-YTVMALSDSSEL- 242
P + P+ A V DS +W +G + Y V S +
Sbjct: 1710 GESQPLVQTAVTNIDRPKGLAFTDVDVDS----IKIAWESPQGQVSRYRVTYSSPEDGIH 1765
Query: 243 ----TCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQED 298
+ + L+ G+EY +SV+A +D S+ T T AP + +
Sbjct: 1766 ELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIG-TQSTAIPAPTDLKFTQV 1824
Query: 299 PPGHLSVAWS--SVDLGDYYV-VFVKSDDGLEVHCNTSLTQCNFLSE---CGFTYFISVF 352
P LS W+ +V L Y V V K G N + + + Y +SV+
Sbjct: 1825 TPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVY 1884
Query: 353 VYNKAGQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNM 411
S P + P + + I W +T+ + G+ +
Sbjct: 1885 ALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRT-------KTETITGFQV 1937
Query: 412 --VECNDTTP----------ACTLSALECDTKYNITVYSFNE 441
V N TP + T++ L+ T Y I +Y+ N+
Sbjct: 1938 DAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1979
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/181 (25%), Positives = 78/181 (43%), Gaps = 13/181 (7%)
Query: 44 SITVEWAT-VPGATSYLLTA--EDGDTVIETTVANSPG--TVTGLKAATWYEITIRSISA 98
+IT+ W T T + + A +G T I+ T+ T+TGL+ T Y+I + +++
Sbjct: 1920 TITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1979
Query: 99 AGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKE 158
RS + + A L + + +S+LV W+ I + I++ GS +E
Sbjct: 1980 NARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARI--TGYIIKYEKPGSPPRE 2037
Query: 159 NTTN-----TSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDS 213
T T T LE GT YTI A N+ + ++T + P +D+
Sbjct: 2038 VVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ-KSEPLIGRKKTVQKTPFVTHPGYDT 2096
Query: 214 G 214
G
Sbjct: 2097 G 2097
>gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]
Length = 2296
Score = 76.3 bits (186), Expect = 1e-13
Identities = 130/570 (22%), Positives = 215/570 (37%), Gaps = 53/570 (9%)
Query: 44 SITVEWATVP--GATSYLLTAEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGR 101
+I + W P G + ++ G+ E T + V+GL Y TI+ +
Sbjct: 1102 TIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQE 1161
Query: 102 SQASPPKQAKTVLAAPI---LEVSSPSSDSILVQWEAVYMA--IAFSVSIMRANGL-GSI 155
A + T L+ P LE ++P + + V WE + ++ NG G+
Sbjct: 1162 RDAPIVNKVVTPLSPPTNLHLE-ANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNS 1220
Query: 156 WKE--NTTNTSLTFTSLEAGTLYTIKAYAWNANR--IPGDDSTCNQRTSPRAPANIQVSF 211
+E + +S TF +L G Y + Y ++ +P D+ P P + F
Sbjct: 1221 LEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTII-----PAVPPPTDLRF 1275
Query: 212 DS-GALKASFSWARAEGA------FNYT-VMALSDSSELTCSTTFSSCTISSLQCGTEYL 263
+ G +WA Y+ V D +EL+ S + ++ +++L GTEY+
Sbjct: 1276 TNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYV 1335
Query: 264 ISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYV---- 317
+SV + + S KT +P + + +V W + + Y +
Sbjct: 1336 VSVSSVYEQHESTPLRGRQ-KTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHP 1394
Query: 318 --VFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCP 375
+ + H S+T N G Y +S+ N +SPL I +T P
Sbjct: 1395 EHFSGRPREDRVPHSRNSITLTNLTP--GTEYVVSIVALNGREESPLL-IGQQSTVSDVP 1451
Query: 376 SDINPVLVSSDRVEIVW-SPVRGAELYE-TKAVDGYNMVECNDTTPA----CTLSALECD 429
D+ V + + I W +P Y T G N T P T+S L+
Sbjct: 1452 RDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPG 1511
Query: 430 TKYNITVYSFNEVRGSNMSCTPQFIT--TAPCSPEIKNVSRDAFSMINVHWRSTNDDAT- 486
Y ITVY+ S S P I T P V+ + I+V W ++ T
Sbjct: 1512 VDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTG 1571
Query: 487 --YTVTAQGEKGLYQCSSTGES---CTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLET 541
T T + G + + G T+ GL + V+ A+ +G S P + T
Sbjct: 1572 YRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTT 1631
Query: 542 VPCCPTGLTVTQITQSVINVSWTIGRVAQT 571
+P PT L TQ+T + ++ WT V T
Sbjct: 1632 IPA-PTDLKFTQVTPTSLSAQWTPPNVQLT 1660
Score = 59.7 bits (143), Expect = 9e-09
Identities = 111/578 (19%), Positives = 216/578 (37%), Gaps = 49/578 (8%)
Query: 75 NSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQW- 133
N+ VTGL Y + ++S S+ +Q + A L+ + + ++LV+W
Sbjct: 959 NTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWT 1018
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGD 191
A +V + R G + + + +L+ + YT+ A N+
Sbjct: 1019 PPRAQITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK 1077
Query: 192 DS---TCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT- 247
+ T Q S P N +V+ + + +W A + S E T
Sbjct: 1078 ATGVFTTLQPGSSIPPYNTEVTETTIVI----TWTPAPRIGFKLGVRPSQGGEAPREVTS 1133
Query: 248 -FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDP-PGHLSV 305
S +S L G EY+ ++ D + + T P + ++ +P G L+V
Sbjct: 1134 DSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTV 1193
Query: 306 AW---SSVDLGDYYVVFVKSD----DGLEVHCNTSLTQCNFLS-ECGFTYFISVFVYNKA 357
+W ++ D+ Y + ++ + LE + + C F + G Y +SV+
Sbjct: 1194 SWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Query: 358 GQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYE-------TKAVDGY 409
+S P+ D P P+D+ + D + + W+P +L K +
Sbjct: 1254 KESVPISDTIIPAVPP--PTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDV 1311
Query: 410 NMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSN-MSCTPQFITTAPCSPEIKNVSR 468
+ + + A L+ L T+Y ++V S E S + + +P + +++
Sbjct: 1312 AELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITA 1371
Query: 469 DAFSMINVHWRSTNDDAT------YTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTA 522
++F+ VHW + T + G + + S T+ L G+ + V+
Sbjct: 1372 NSFT---VHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSI 1428
Query: 523 VAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQTHVAVLESHTG- 581
VA S P TV P L V T + + +SW V + + TG
Sbjct: 1429 VALNGREES-PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGG 1487
Query: 582 -----QSKCHTHQNHCLLGCITCGINYTVTLKAISATG 614
+ ++ + + G++YT+T+ A++ G
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1525
Score = 56.2 bits (134), Expect = 1e-07
Identities = 90/374 (24%), Positives = 140/374 (37%), Gaps = 47/374 (12%)
Query: 241 ELTCSTTFSSCTISSLQCGTEY---LISV------------LASNDAGSSKSSSAMTLKT 285
E T +S TI L+ G Y LIS+ + + +S+ +T +T
Sbjct: 656 EATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET 715
Query: 286 VACAPGRVT---IQEDPPGHLSVAWSSVD--LGDYYVVFVKSDDGLE---VHCNTSLTQC 337
+P T + E V+W S + + V + S++G E + ++ T
Sbjct: 716 TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSV 775
Query: 338 NFLSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWS--- 393
N G Y ++V+ ++ G+ L + TTAP P D V + + WS
Sbjct: 776 NIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQ 835
Query: 394 -PVRGAELYETKAVDGYNMVECN--DTTPACTLSALECDTKYNITVYSFNEVRGSNMSCT 450
P+ G + + +V+G + E N +T + TLS L+ +YNIT+Y+ E + S
Sbjct: 836 APITGYRIVYSPSVEG-SSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVI 894
Query: 451 PQFITTAPCSPEIKNVSRDAF-----SMINVHWRSTNDDAT------YTVTAQGEKGLYQ 499
Q T P S + + F + + W T V GE G
Sbjct: 895 QQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRL 954
Query: 500 CSSTGESCTMRGLPCGSV--FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQS 557
S + GL G F V AV+ GR + T PT L T S
Sbjct: 955 PISRNTFAEVTGLSPGVTYYFKVFAVSH---GRESKPLTAQQTTKLDAPTNLQFVNETDS 1011
Query: 558 VINVSWTIGRVAQT 571
+ V WT R T
Sbjct: 1012 TVLVRWTPPRAQIT 1025
Score = 56.2 bits (134), Expect = 1e-07
Identities = 101/440 (22%), Positives = 161/440 (36%), Gaps = 52/440 (11%)
Query: 42 SNSITVEW----ATVPGATSYLLTAEDGDTVIETTVANSPG--TVTGLKAATWYEITIRS 95
+NS TV W AT+ G E V +S T+T L T Y ++I +
Sbjct: 1371 ANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVA 1430
Query: 96 ISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
++ S +Q+ LEV + + S+L+ W+A + + + G S
Sbjct: 1431 LNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSP 1490
Query: 156 WKENT---TNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDS------TCNQRTSPRAPAN 206
+E T + ++ T + L+ G YTI YA GD + N RT P+
Sbjct: 1491 VQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR---GDSPASSKPISINYRTEIDKPSQ 1547
Query: 207 IQVSFDSGALKASFSWARAEG-AFNYTVMAL-----SDSSELTCSTTFSSCTISSLQCGT 260
+QV+ D S W + Y V + T + TI LQ
Sbjct: 1548 MQVT-DVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV 1606
Query: 261 EYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWS--SVDLGDYYV- 317
EY++SV A N +G S+ T T AP + + P LS W+ +V L Y V
Sbjct: 1607 EYVVSVYAQNPSGESQ-PLVQTAVTTIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVR 1665
Query: 318 VFVKSDDGLEVHCNTSLTQCNFLSE---CGFTYFISVFVYNKAGQS-PLGDIFNYTTAPC 373
V K G N + + + Y +SV+ S P +
Sbjct: 1666 VTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVS 1725
Query: 374 CPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNM--VECNDTTP----------AC 421
P + + I W +T+ + G+ + V N TP +
Sbjct: 1726 PPRRARVTDATETTITISWRT-------KTETITGFQVDAVPANGQTPIQRTIKPDVRSY 1778
Query: 422 TLSALECDTKYNITVYSFNE 441
T++ L+ T Y I +Y+ N+
Sbjct: 1779 TITGLQPGTDYKIYLYTLND 1798
Score = 53.9 bits (128), Expect = 5e-07
Identities = 84/406 (20%), Positives = 161/406 (39%), Gaps = 38/406 (9%)
Query: 21 MVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLLTAEDGDT-----VIETTV-- 73
++ + ++P + + S+ + W P T G+T V E TV
Sbjct: 1440 LIGQQSTVSDVPRDLEVVAATPTSLLISW-DAPAVTVRYYRITYGETGGNSPVQEFTVPG 1498
Query: 74 ANSPGTVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAPI-LEVSSPSSDSI 129
+ S T++GLK Y IT+ +++ G S AS +T + P ++V+ +SI
Sbjct: 1499 SKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSI 1558
Query: 130 LVQW-EAVYMAIAFSVSIMRANGLGSIWKENT--TNTSLTFTSLEAGTLYTIKAYAWNAN 186
V+W + + V+ NG G + T +T L+ Y + YA N +
Sbjct: 1559 SVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPS 1618
Query: 187 RIPGDDSTCNQRTSPRAPANIQVSFDS---GALKASFSWARAEGAFNYTVMA-----LSD 238
G+ Q PA + F +L A ++ + Y V
Sbjct: 1619 ---GESQPLVQTAVTTIPAPTDLKFTQVTPTSLSAQWTPPNVQ-LTGYRVRVTPKEKTGP 1674
Query: 239 SSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAM--TLKTVACAPGRVTIQ 296
E+ + SS +S L T+Y +SV A D +S+ + + TL+ V+ P R +
Sbjct: 1675 MKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVS-PPRRARVT 1733
Query: 297 EDPPGHLSVAW--SSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFL---SECGFTYFISV 351
+ ++++W + + + V V ++ + ++ + G Y I +
Sbjct: 1734 DATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYL 1793
Query: 352 FVYN-KAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVR 396
+ N A SP+ + + +TA PS++ + + + + + W P R
Sbjct: 1794 YTLNDNARSSPV--VIDASTAIDAPSNLRFLATTPNSLLVSWQPPR 1837
Score = 39.7 bits (91), Expect = 0.010
Identities = 42/154 (27%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 44 SITVEWAT-VPGATSYLLTA--EDGDTVIETTVANSPG--TVTGLKAATWYEITIRSISA 98
+IT+ W T T + + A +G T I+ T+ T+TGL+ T Y+I + +++
Sbjct: 1739 TITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1798
Query: 99 AGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKE 158
RS + + A L + + +S+LV W+ I + I++ GS +E
Sbjct: 1799 NARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARI--TGYIIKYEKPGSPPRE 1856
Query: 159 NTTN-----TSLTFTSLEAGTLYTIKAYAWNANR 187
T T T LE GT YTI A N+
Sbjct: 1857 VVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1890
>gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]
Length = 2176
Score = 76.3 bits (186), Expect = 1e-13
Identities = 130/570 (22%), Positives = 215/570 (37%), Gaps = 53/570 (9%)
Query: 44 SITVEWATVP--GATSYLLTAEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGR 101
+I + W P G + ++ G+ E T + V+GL Y TI+ +
Sbjct: 1102 TIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQE 1161
Query: 102 SQASPPKQAKTVLAAPI---LEVSSPSSDSILVQWEAVYMA--IAFSVSIMRANGL-GSI 155
A + T L+ P LE ++P + + V WE + ++ NG G+
Sbjct: 1162 RDAPIVNKVVTPLSPPTNLHLE-ANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNS 1220
Query: 156 WKE--NTTNTSLTFTSLEAGTLYTIKAYAWNANR--IPGDDSTCNQRTSPRAPANIQVSF 211
+E + +S TF +L G Y + Y ++ +P D+ P P + F
Sbjct: 1221 LEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDTII-----PAVPPPTDLRF 1275
Query: 212 DS-GALKASFSWARAEGA------FNYT-VMALSDSSELTCSTTFSSCTISSLQCGTEYL 263
+ G +WA Y+ V D +EL+ S + ++ +++L GTEY+
Sbjct: 1276 TNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYV 1335
Query: 264 ISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYV---- 317
+SV + + S KT +P + + +V W + + Y +
Sbjct: 1336 VSVSSVYEQHESTPLRGRQ-KTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHP 1394
Query: 318 --VFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCP 375
+ + H S+T N G Y +S+ N +SPL I +T P
Sbjct: 1395 EHFSGRPREDRVPHSRNSITLTNLTP--GTEYVVSIVALNGREESPLL-IGQQSTVSDVP 1451
Query: 376 SDINPVLVSSDRVEIVW-SPVRGAELYE-TKAVDGYNMVECNDTTPA----CTLSALECD 429
D+ V + + I W +P Y T G N T P T+S L+
Sbjct: 1452 RDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPG 1511
Query: 430 TKYNITVYSFNEVRGSNMSCTPQFIT--TAPCSPEIKNVSRDAFSMINVHWRSTNDDAT- 486
Y ITVY+ S S P I T P V+ + I+V W ++ T
Sbjct: 1512 VDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTG 1571
Query: 487 --YTVTAQGEKGLYQCSSTGES---CTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLET 541
T T + G + + G T+ GL + V+ A+ +G S P + T
Sbjct: 1572 YRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTT 1631
Query: 542 VPCCPTGLTVTQITQSVINVSWTIGRVAQT 571
+P PT L TQ+T + ++ WT V T
Sbjct: 1632 IPA-PTDLKFTQVTPTSLSAQWTPPNVQLT 1660
Score = 63.9 bits (154), Expect = 5e-10
Identities = 110/545 (20%), Positives = 206/545 (37%), Gaps = 61/545 (11%)
Query: 21 MVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLLTAEDGDT-----VIETTV-- 73
++ + ++P + + S+ + W P T G+T V E TV
Sbjct: 1440 LIGQQSTVSDVPRDLEVVAATPTSLLISW-DAPAVTVRYYRITYGETGGNSPVQEFTVPG 1498
Query: 74 ANSPGTVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAPI-LEVSSPSSDSI 129
+ S T++GLK Y IT+ +++ G S AS +T + P ++V+ +SI
Sbjct: 1499 SKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSI 1558
Query: 130 LVQW-EAVYMAIAFSVSIMRANGLGSIWKENT--TNTSLTFTSLEAGTLYTIKAYAWNAN 186
V+W + + V+ NG G + T +T L+ Y + YA N +
Sbjct: 1559 SVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPS 1618
Query: 187 RIPGDDSTCNQRTSPRAPANIQVSFDS---GALKASFSWARAEGAFNYTVMA-----LSD 238
G+ Q PA + F +L A ++ + Y V
Sbjct: 1619 ---GESQPLVQTAVTTIPAPTDLKFTQVTPTSLSAQWTPPNVQ-LTGYRVRVTPKEKTGP 1674
Query: 239 SSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAM--TLKTVACAPGRVTIQ 296
E+ + SS +S L T+Y +SV A D +S+ + + TL+ V+ P R +
Sbjct: 1675 MKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVS-PPRRARVT 1733
Query: 297 EDPPGHLSVAW--SSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFL---SECGFTYFISV 351
+ ++++W + + + V V ++ + ++ + G Y I +
Sbjct: 1734 DATETTITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYL 1793
Query: 352 FVYN-KAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAEL-----YETKA 405
+ N A SP+ + + +TA PS++ + + + + + W P R YE
Sbjct: 1794 YTLNDNARSSPV--VIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPG 1851
Query: 406 VDGYNMV-ECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIK 464
+V T++ LE T+Y I V + +N P K
Sbjct: 1852 SPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALK----NNQKSEPLI--------GRK 1899
Query: 465 NVSRDAFSMINVHWRSTNDDATYTVT-----AQGEKGLYQCSSTGESCTMRGLPCGSVFS 519
++A S + W D + Y ++ E ++ T S T+ GL G+ ++
Sbjct: 1900 KTGQEALSQTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYN 1959
Query: 520 VTAVA 524
+ A
Sbjct: 1960 IIVEA 1964
Score = 59.7 bits (143), Expect = 9e-09
Identities = 111/578 (19%), Positives = 216/578 (37%), Gaps = 49/578 (8%)
Query: 75 NSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQW- 133
N+ VTGL Y + ++S S+ +Q + A L+ + + ++LV+W
Sbjct: 959 NTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWT 1018
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGD 191
A +V + R G + + + +L+ + YT+ A N+
Sbjct: 1019 PPRAQITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK 1077
Query: 192 DS---TCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT- 247
+ T Q S P N +V+ + + +W A + S E T
Sbjct: 1078 ATGVFTTLQPGSSIPPYNTEVTETTIVI----TWTPAPRIGFKLGVRPSQGGEAPREVTS 1133
Query: 248 -FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDP-PGHLSV 305
S +S L G EY+ ++ D + + T P + ++ +P G L+V
Sbjct: 1134 DSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTV 1193
Query: 306 AW---SSVDLGDYYVVFVKSD----DGLEVHCNTSLTQCNFLS-ECGFTYFISVFVYNKA 357
+W ++ D+ Y + ++ + LE + + C F + G Y +SV+
Sbjct: 1194 SWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Query: 358 GQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYE-------TKAVDGY 409
+S P+ D P P+D+ + D + + W+P +L K +
Sbjct: 1254 KESVPISDTIIPAVPP--PTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDV 1311
Query: 410 NMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSN-MSCTPQFITTAPCSPEIKNVSR 468
+ + + A L+ L T+Y ++V S E S + + +P + +++
Sbjct: 1312 AELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITA 1371
Query: 469 DAFSMINVHWRSTNDDAT------YTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTA 522
++F+ VHW + T + G + + S T+ L G+ + V+
Sbjct: 1372 NSFT---VHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSI 1428
Query: 523 VAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQTHVAVLESHTG- 581
VA S P TV P L V T + + +SW V + + TG
Sbjct: 1429 VALNGREES-PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGG 1487
Query: 582 -----QSKCHTHQNHCLLGCITCGINYTVTLKAISATG 614
+ ++ + + G++YT+T+ A++ G
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1525
Score = 56.2 bits (134), Expect = 1e-07
Identities = 90/374 (24%), Positives = 140/374 (37%), Gaps = 47/374 (12%)
Query: 241 ELTCSTTFSSCTISSLQCGTEY---LISV------------LASNDAGSSKSSSAMTLKT 285
E T +S TI L+ G Y LIS+ + + +S+ +T +T
Sbjct: 656 EATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET 715
Query: 286 VACAPGRVT---IQEDPPGHLSVAWSSVD--LGDYYVVFVKSDDGLE---VHCNTSLTQC 337
+P T + E V+W S + + V + S++G E + ++ T
Sbjct: 716 TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSV 775
Query: 338 NFLSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWS--- 393
N G Y ++V+ ++ G+ L + TTAP P D V + + WS
Sbjct: 776 NIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQ 835
Query: 394 -PVRGAELYETKAVDGYNMVECN--DTTPACTLSALECDTKYNITVYSFNEVRGSNMSCT 450
P+ G + + +V+G + E N +T + TLS L+ +YNIT+Y+ E + S
Sbjct: 836 APITGYRIVYSPSVEG-SSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVI 894
Query: 451 PQFITTAPCSPEIKNVSRDAF-----SMINVHWRSTNDDAT------YTVTAQGEKGLYQ 499
Q T P S + + F + + W T V GE G
Sbjct: 895 QQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRL 954
Query: 500 CSSTGESCTMRGLPCGSV--FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQS 557
S + GL G F V AV+ GR + T PT L T S
Sbjct: 955 PISRNTFAEVTGLSPGVTYYFKVFAVSH---GRESKPLTAQQTTKLDAPTNLQFVNETDS 1011
Query: 558 VINVSWTIGRVAQT 571
+ V WT R T
Sbjct: 1012 TVLVRWTPPRAQIT 1025
Score = 56.2 bits (134), Expect = 1e-07
Identities = 101/440 (22%), Positives = 161/440 (36%), Gaps = 52/440 (11%)
Query: 42 SNSITVEW----ATVPGATSYLLTAEDGDTVIETTVANSPG--TVTGLKAATWYEITIRS 95
+NS TV W AT+ G E V +S T+T L T Y ++I +
Sbjct: 1371 ANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVA 1430
Query: 96 ISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
++ S +Q+ LEV + + S+L+ W+A + + + G S
Sbjct: 1431 LNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSP 1490
Query: 156 WKENT---TNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDS------TCNQRTSPRAPAN 206
+E T + ++ T + L+ G YTI YA GD + N RT P+
Sbjct: 1491 VQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR---GDSPASSKPISINYRTEIDKPSQ 1547
Query: 207 IQVSFDSGALKASFSWARAEG-AFNYTVMAL-----SDSSELTCSTTFSSCTISSLQCGT 260
+QV+ D S W + Y V + T + TI LQ
Sbjct: 1548 MQVT-DVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV 1606
Query: 261 EYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWS--SVDLGDYYV- 317
EY++SV A N +G S+ T T AP + + P LS W+ +V L Y V
Sbjct: 1607 EYVVSVYAQNPSGESQ-PLVQTAVTTIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVR 1665
Query: 318 VFVKSDDGLEVHCNTSLTQCNFLSE---CGFTYFISVFVYNKAGQS-PLGDIFNYTTAPC 373
V K G N + + + Y +SV+ S P +
Sbjct: 1666 VTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLENVS 1725
Query: 374 CPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNM--VECNDTTP----------AC 421
P + + I W +T+ + G+ + V N TP +
Sbjct: 1726 PPRRARVTDATETTITISWRT-------KTETITGFQVDAVPANGQTPIQRTIKPDVRSY 1778
Query: 422 TLSALECDTKYNITVYSFNE 441
T++ L+ T Y I +Y+ N+
Sbjct: 1779 TITGLQPGTDYKIYLYTLND 1798
Score = 42.0 bits (97), Expect = 0.002
Identities = 58/243 (23%), Positives = 97/243 (39%), Gaps = 29/243 (11%)
Query: 44 SITVEWAT-VPGATSYLLTA--EDGDTVIETTVANSPG--TVTGLKAATWYEITIRSISA 98
+IT+ W T T + + A +G T I+ T+ T+TGL+ T Y+I + +++
Sbjct: 1739 TITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1798
Query: 99 AGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKE 158
RS + + A L + + +S+LV W+ I + I++ GS +E
Sbjct: 1799 NARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARI--TGYIIKYEKPGSPPRE 1856
Query: 159 NTTN-----TSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDS 213
T T T LE GT YTI A N+ + ++T A +
Sbjct: 1857 VVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ-KSEPLIGRKKTGQEALS-------- 1907
Query: 214 GALKASFSWARAEGAFNYTVMAL-----SDSSELTCSTTFSSCTISSLQCGTEYLISVLA 268
+ + SWA + Y + + + T +S T++ L G Y I V A
Sbjct: 1908 ---QTTISWAPFQDTSEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNIIVEA 1964
Query: 269 SND 271
D
Sbjct: 1965 LKD 1967
>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
Length = 2944
Score = 72.4 bits (176), Expect = 1e-12
Identities = 122/561 (21%), Positives = 209/561 (37%), Gaps = 48/561 (8%)
Query: 42 SNSITVEWATVPG-ATSYL-----LTAEDGDTVIETTVANSPGTVT-----GLKAATWYE 90
S S+ V+W G T Y LT E N P T GL+ T Y+
Sbjct: 245 SQSLRVQWTAASGPVTGYKVQYTPLTGLGQPLPSERQEVNVPAGETSVRLRGLRPLTEYQ 304
Query: 91 ITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRAN 150
+T+ ++ A +A T L P L + + ++ S+LV W +V A + V+ +
Sbjct: 305 VTVIALYANSIGEAVSGTARTTALEGPELTIQNTTAHSLLVAWRSVPGATGYRVTWRVLS 364
Query: 151 GLGSIWKE-NTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQV 209
G + +E S+ LE GT Y + + R G ++ RT ++
Sbjct: 365 GGPTQQQELGPGQGSVLLRDLEPGTDYEV-TVSTLFGRSVGPATSLMARTDASVEQTLRP 423
Query: 210 SFDSGALKASFSWARAEGAFNYTV-----MALSDSSELTCSTTFSSCTISSLQCGTEYLI 264
G SW A Y + L ++ + + + LQ GTEY +
Sbjct: 424 VI-LGPTSILLSWNLVPEARGYRLEWRRETGLEPPQKVVLPSDVTRYQLDGLQPGTEYRL 482
Query: 265 SVLASNDAGSSKSSSAMTLKTVACAP----GRVTIQEDPPGHLSVAWSSVDLGDYYVVFV 320
++ + G ++ A + T P + E P + V+WS V Y + V
Sbjct: 483 TLYTLLE-GHEVATPATVVPTGPELPVSPVTDLQATELPGQRVRVSWSPVPGATQYRIIV 541
Query: 321 KSDDGLE-----VHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCP 375
+S G+E T+ + + +T +S V + G + + + P
Sbjct: 542 RSTQGVERTLVLPGSQTAFDLDDVQAGLSYTVRVSARVGPREGSASVLTVRREPETPLAV 601
Query: 376 SDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVECNDTTP----ACTLSALECDTK 431
+ V+ + RV + W PV GA + G + E + T P A ++ L+ T
Sbjct: 602 PGLRVVVSDATRVRVAWGPVPGASGFRISWSTG-SGPESSQTLPPDSTATDITGLQPGTT 660
Query: 432 YNITVYSFNEVRGSNMSCTPQFIT-TAPCSP-EIKNVSRDAFSMINVHWRSTNDDATYTV 489
Y + V + +RG + T P P +V++ + S + + W Y V
Sbjct: 661 YQVAV---SVLRGREEGPAAVIVARTDPLGPVRTVHVTQASSSSVTITWTRVPGATGYRV 717
Query: 490 ---TAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCP 546
+A G + S + GL + ++V A AG P SV + T P P
Sbjct: 718 SWHSAHGPEKSQLVSGEATVAELDGLEPDTEYTVHVRAHV-AGVDGPPASVVVRTAP-EP 775
Query: 547 TG----LTVTQITQSVINVSW 563
G L + + V+ ++W
Sbjct: 776 VGRVSRLQILNASSDVLRITW 796
Score = 72.4 bits (176), Expect = 1e-12
Identities = 135/570 (23%), Positives = 214/570 (37%), Gaps = 57/570 (10%)
Query: 21 MVASAKSAPEIPTID-QAYSKLSNSITVEWATVPGATSYLLTAEDGDTVIETTVANSPGT 79
+V + P P D QA + V W+ VPGAT Y + V T V PG+
Sbjct: 499 VVPTGPELPVSPVTDLQATELPGQRVRVSWSPVPGATQYRIIVRSTQGVERTLVL--PGS 556
Query: 80 VTGL---KAATWYEITIRSISAAGRSQASPP-----KQAKTVLAAPILEVSSPSSDSILV 131
T T+R + G + S ++ +T LA P L V + + V
Sbjct: 557 QTAFDLDDVQAGLSYTVRVSARVGPREGSASVLTVRREPETPLAVPGLRVVVSDATRVRV 616
Query: 132 QWEAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGD 191
W V A F +S +G S +T+ T L+ GT Y + A + R G
Sbjct: 617 AWGPVPGASGFRISWSTGSGPESSQTLPPDSTATDITGLQPGTTYQV-AVSVLRGREEGP 675
Query: 192 DSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALS----DSSELTCSTT 247
+ RT P P + + + +W R GA Y V S + S+L S
Sbjct: 676 AAVIVARTDPLGPVRTVHVTQASSSSVTITWTRVPGATGYRVSWHSAHGPEKSQLV-SGE 734
Query: 248 FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVT---IQEDPPGHLS 304
+ + L+ TEY + V A + AG +++ ++T GRV+ I L
Sbjct: 735 ATVAELDGLEPDTEYTVHVRA-HVAGVDGPPASVVVRTAPEPVGRVSRLQILNASSDVLR 793
Query: 305 VAWSSV-DLGDYYVVFVKSDDGLEVH----CNTSLTQCNFLSECGFTYFISV--FVYNKA 357
+ W V Y + + +S+ G H NT + L E G +Y + V V ++
Sbjct: 794 ITWVGVTGATAYRLAWGRSEGGPMRHQILPGNTDSAEIRGL-EGGVSYSVRVTALVGDRE 852
Query: 358 GQSPLGDIFNYTTAPCCPSDINPVLV---SSDRVEIVWSPVRGAE--LYETKAVDGYNMV 412
G +P+ + TT P P + + V + + W PV A+ L + G
Sbjct: 853 G-TPVSIV--VTTPPEAPPALGTLHVVQRGEHSLRLRWEPVPRAQGFLLHWQPEGGQEQS 909
Query: 413 E-CNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIK-NVSRDA 470
+ L LE T+Y + + S G S T +P P I+ V +
Sbjct: 910 RVLGPELSSYHLDGLEPATQYRVRL-SVLGPAGEGPSAEVTARTESPRVPSIELRVVDTS 968
Query: 471 FSMINVHWRSTNDDATYTVTAQGEKGLYQCSSTGESCTMRGLPCGS-----------VFS 519
+ + W + ++Y ++ + +G Q G T+ G+ +FS
Sbjct: 969 IDSVTLAWTPVSRASSYILSWRPLRGPGQ-EVPGSPQTLPGISSSQRVTGLEPGVSYIFS 1027
Query: 520 VTAVAETQAGRSLPSYSVPLETVPCCPTGL 549
+T V + G P SV P CP GL
Sbjct: 1028 LTPVLDGVRG---PEASV--TQTPVCPRGL 1052
Score = 53.9 bits (128), Expect = 5e-07
Identities = 109/502 (21%), Positives = 193/502 (38%), Gaps = 46/502 (9%)
Query: 97 SAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAI-AFSVSIMRANGLGSI 155
+A G PP + + A L +S PSS S+ VQW A + + V GLG
Sbjct: 218 TAGGVPVTRPPDDSTS--APRDLVLSEPSSQSLRVQWTAASGPVTGYKVQYTPLTGLGQP 275
Query: 156 WKEN-------TTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQ 208
TS+ L T Y + A AN I G+ + RT+ +
Sbjct: 276 LPSERQEVNVPAGETSVRLRGLRPLTEYQVTVIALYANSI-GEAVSGTARTTALEGPELT 334
Query: 209 VSFDSGALKASFSWARAEGAFNY----TVMALSDSSELTCSTTFSSCTISSLQCGTEY-- 262
+ ++ A +W GA Y V++ + + S + L+ GT+Y
Sbjct: 335 IQ-NTTAHSLLVAWRSVPGATGYRVTWRVLSGGPTQQQELGPGQGSVLLRDLEPGTDYEV 393
Query: 263 LISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYYVVFVKS 322
+S L G + S A T +V V + P + ++W+ V Y + +
Sbjct: 394 TVSTLFGRSVGPATSLMARTDASVEQTLRPVIL---GPTSILLSWNLVPEARGYRLEWRR 450
Query: 323 DDGLE------VHCNTSLTQCNFLSECGFTYFISVFVYNKAGQ--SPLGDIFNYTTAPCC 374
+ GLE + + + Q + L + G Y ++++ + + +P + P
Sbjct: 451 ETGLEPPQKVVLPSDVTRYQLDGL-QPGTEYRLTLYTLLEGHEVATPATVVPTGPELPVS 509
Query: 375 P-SDINPVLVSSDRVEIVWSPVRGAELY-----ETKAVDGYNMVECNDTTPACTLSALEC 428
P +D+ + RV + WSPV GA Y T+ V+ ++ + T A L ++
Sbjct: 510 PVTDLQATELPGQRVRVSWSPVPGATQYRIIVRSTQGVERTLVLPGSQT--AFDLDDVQA 567
Query: 429 DTKYNITVYS-FNEVRGSNMSCTPQFITTAPCS-PEIKNVSRDAFSMINVHWRSTNDDAT 486
Y + V + GS T + P + P ++ V DA + + V W +
Sbjct: 568 GLSYTVRVSARVGPREGSASVLTVRREPETPLAVPGLRVVVSDA-TRVRVAWGPVPGASG 626
Query: 487 YTV---TAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVP 543
+ + T G + + + GL G+ + V AV+ + P+ + T P
Sbjct: 627 FRISWSTGSGPESSQTLPPDSTATDITGLQPGTTYQV-AVSVLRGREEGPAAVIVARTDP 685
Query: 544 CCPT-GLTVTQITQSVINVSWT 564
P + VTQ + S + ++WT
Sbjct: 686 LGPVRTVHVTQASSSSVTITWT 707
>gi|16933542 fibronectin 1 isoform 3 preproprotein [Homo sapiens]
Length = 2355
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/562 (22%), Positives = 207/562 (36%), Gaps = 49/562 (8%)
Query: 42 SNSITVEW----ATVPGATSYLLTAEDGDTVIETTVANSPG--TVTGLKAATWYEITIRS 95
+NS TV W AT+ G E V +S T+T L T Y ++I +
Sbjct: 1371 ANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVA 1430
Query: 96 ISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
++ S +Q+ LEV + + S+L+ W+A + + + G S
Sbjct: 1431 LNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSP 1490
Query: 156 WKENT---TNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDS------TCNQRTSPRAPAN 206
+E T + ++ T + L+ G YTI YA GD + N RT P+
Sbjct: 1491 VQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR---GDSPASSKPISINYRTEIDKPSQ 1547
Query: 207 IQVSFDSGALKASFSWARAEG-AFNYTVMAL-----SDSSELTCSTTFSSCTISSLQCGT 260
+QV+ D S W + Y V + T + TI LQ
Sbjct: 1548 MQVT-DVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV 1606
Query: 261 EYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSV--DLGDYYVV 318
EY++SV A N +G S+ T T P + + + +AW S + Y V
Sbjct: 1607 EYVVSVYAQNPSGESQ-PLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVT 1665
Query: 319 FVKSDDGLE-----VHCNTSLTQCNFLSECGFTYFISVF-VYNKAGQSPLGDIFNYTTAP 372
+ +DG+ + L G Y +SV +++ PL I +TA
Sbjct: 1666 YSSPEDGIHELFPAPDGEEDTAELQGLRP-GSEYTVSVVALHDDMESQPL--IGTQSTAI 1722
Query: 373 CCPSDINPVLVSSDRVEIVWSP----VRGAELYETKAVDGYNMVECN--DTTPACTLSAL 426
P+D+ V+ + W+P + G + T M E N + + +S L
Sbjct: 1723 PAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGL 1782
Query: 427 ECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT 486
TKY ++VY+ + S + P V+ + I + WR+ + T
Sbjct: 1783 MVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETIT 1842
Query: 487 ----YTVTAQGEKGLYQCSSTG-ESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLET 541
V A G+ + + S T+ GL G+ + + RS P + T
Sbjct: 1843 GFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSP-VVIDAST 1901
Query: 542 VPCCPTGLTVTQITQSVINVSW 563
P+ L T + + VSW
Sbjct: 1902 AIDAPSNLRFLATTPNSLLVSW 1923
Score = 64.3 bits (155), Expect = 4e-10
Identities = 84/346 (24%), Positives = 137/346 (39%), Gaps = 29/346 (8%)
Query: 249 SSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWS 308
+S T+++L GTEY++S++A N S TV+ P + + P L ++W
Sbjct: 1411 NSITLTNLTPGTEYVVSIVALNGREESPLLIGQQ-STVSDVPRDLEVVAATPTSLLISWD 1469
Query: 309 SVDLGDYYVVFVKSDDG-------LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSP 361
+ + Y + G V + S + L G Y I+V+ G SP
Sbjct: 1470 APAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP-GVDYTITVYAVTGRGDSP 1528
Query: 362 LGD---IFNYTTAPCCPSDINPVLVSSDRVEIVW----SPVRGAELYETKAVDGYNMVEC 414
NY T PS + V + + + W SPV G + T +G +
Sbjct: 1529 ASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPK-NGPGPTKT 1587
Query: 415 NDTTP---ACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAF 471
P T+ L+ +Y ++VY+ N G + +T + D
Sbjct: 1588 KTAGPDQTEMTIEGLQPTVEYVVSVYAQNP-SGESQPLVQTAVTNIDRPKGLAFTDVDVD 1646
Query: 472 SMINVHWRSTNDDAT-YTVT-AQGEKGLYQC--SSTGESCT--MRGLPCGSVFSVTAVAE 525
S I + W S + Y VT + E G+++ + GE T ++GL GS ++V+ VA
Sbjct: 1647 S-IKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVAL 1705
Query: 526 TQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQT 571
S P +P PT L TQ+T + ++ WT V T
Sbjct: 1706 HDDMESQPLIGTQSTAIPA-PTDLKFTQVTPTSLSAQWTPPNVQLT 1750
Score = 59.7 bits (143), Expect = 9e-09
Identities = 111/578 (19%), Positives = 216/578 (37%), Gaps = 49/578 (8%)
Query: 75 NSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQW- 133
N+ VTGL Y + ++S S+ +Q + A L+ + + ++LV+W
Sbjct: 959 NTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWT 1018
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGD 191
A +V + R G + + + +L+ + YT+ A N+
Sbjct: 1019 PPRAQITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK 1077
Query: 192 DS---TCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT- 247
+ T Q S P N +V+ + + +W A + S E T
Sbjct: 1078 ATGVFTTLQPGSSIPPYNTEVTETTIVI----TWTPAPRIGFKLGVRPSQGGEAPREVTS 1133
Query: 248 -FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDP-PGHLSV 305
S +S L G EY+ ++ D + + T P + ++ +P G L+V
Sbjct: 1134 DSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTV 1193
Query: 306 AW---SSVDLGDYYVVFVKSD----DGLEVHCNTSLTQCNFLS-ECGFTYFISVFVYNKA 357
+W ++ D+ Y + ++ + LE + + C F + G Y +SV+
Sbjct: 1194 SWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Query: 358 GQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYE-------TKAVDGY 409
+S P+ D P P+D+ + D + + W+P +L K +
Sbjct: 1254 KESVPISDTIIPAVPP--PTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDV 1311
Query: 410 NMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSN-MSCTPQFITTAPCSPEIKNVSR 468
+ + + A L+ L T+Y ++V S E S + + +P + +++
Sbjct: 1312 AELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITA 1371
Query: 469 DAFSMINVHWRSTNDDAT------YTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTA 522
++F+ VHW + T + G + + S T+ L G+ + V+
Sbjct: 1372 NSFT---VHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSI 1428
Query: 523 VAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQTHVAVLESHTG- 581
VA S P TV P L V T + + +SW V + + TG
Sbjct: 1429 VALNGREES-PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGG 1487
Query: 582 -----QSKCHTHQNHCLLGCITCGINYTVTLKAISATG 614
+ ++ + + G++YT+T+ A++ G
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1525
Score = 56.2 bits (134), Expect = 1e-07
Identities = 90/374 (24%), Positives = 140/374 (37%), Gaps = 47/374 (12%)
Query: 241 ELTCSTTFSSCTISSLQCGTEY---LISV------------LASNDAGSSKSSSAMTLKT 285
E T +S TI L+ G Y LIS+ + + +S+ +T +T
Sbjct: 656 EATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET 715
Query: 286 VACAPGRVT---IQEDPPGHLSVAWSSVD--LGDYYVVFVKSDDGLE---VHCNTSLTQC 337
+P T + E V+W S + + V + S++G E + ++ T
Sbjct: 716 TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSV 775
Query: 338 NFLSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWS--- 393
N G Y ++V+ ++ G+ L + TTAP P D V + + WS
Sbjct: 776 NIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQ 835
Query: 394 -PVRGAELYETKAVDGYNMVECN--DTTPACTLSALECDTKYNITVYSFNEVRGSNMSCT 450
P+ G + + +V+G + E N +T + TLS L+ +YNIT+Y+ E + S
Sbjct: 836 APITGYRIVYSPSVEG-SSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVI 894
Query: 451 PQFITTAPCSPEIKNVSRDAF-----SMINVHWRSTNDDAT------YTVTAQGEKGLYQ 499
Q T P S + + F + + W T V GE G
Sbjct: 895 QQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRL 954
Query: 500 CSSTGESCTMRGLPCGSV--FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQS 557
S + GL G F V AV+ GR + T PT L T S
Sbjct: 955 PISRNTFAEVTGLSPGVTYYFKVFAVSH---GRESKPLTAQQTTKLDAPTNLQFVNETDS 1011
Query: 558 VINVSWTIGRVAQT 571
+ V WT R T
Sbjct: 1012 TVLVRWTPPRAQIT 1025
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/462 (21%), Positives = 167/462 (36%), Gaps = 54/462 (11%)
Query: 21 MVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLLTAEDGDT-----VIETTV-- 73
++ + ++P + + S+ + W P T G+T V E TV
Sbjct: 1440 LIGQQSTVSDVPRDLEVVAATPTSLLISW-DAPAVTVRYYRITYGETGGNSPVQEFTVPG 1498
Query: 74 ANSPGTVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAPI-LEVSSPSSDSI 129
+ S T++GLK Y IT+ +++ G S AS +T + P ++V+ +SI
Sbjct: 1499 SKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSI 1558
Query: 130 LVQW-EAVYMAIAFSVSIMRANGLGSIWKENT--TNTSLTFTSLEAGTLYTIKAYAWN-- 184
V+W + + V+ NG G + T +T L+ Y + YA N
Sbjct: 1559 SVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPS 1618
Query: 185 ANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFN-YTVMALSDSSEL- 242
P + P+ A V DS +W +G + Y V S +
Sbjct: 1619 GESQPLVQTAVTNIDRPKGLAFTDVDVDS----IKIAWESPQGQVSRYRVTYSSPEDGIH 1674
Query: 243 ----TCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQED 298
+ + L+ G+EY +SV+A +D S+ T T AP + +
Sbjct: 1675 ELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIG-TQSTAIPAPTDLKFTQV 1733
Query: 299 PPGHLSVAWS--SVDLGDYYV-VFVKSDDGLEVHCNTSLTQCNFLSE---CGFTYFISVF 352
P LS W+ +V L Y V V K G N + + + Y +SV+
Sbjct: 1734 TPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVY 1793
Query: 353 VYNKAGQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNM 411
S P + P + + I W +T+ + G+ +
Sbjct: 1794 ALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRT-------KTETITGFQV 1846
Query: 412 --VECNDTTP----------ACTLSALECDTKYNITVYSFNE 441
V N TP + T++ L+ T Y I +Y+ N+
Sbjct: 1847 DAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1888
Score = 39.7 bits (91), Expect = 0.010
Identities = 42/154 (27%), Positives = 68/154 (44%), Gaps = 12/154 (7%)
Query: 44 SITVEWAT-VPGATSYLLTA--EDGDTVIETTVANSPG--TVTGLKAATWYEITIRSISA 98
+IT+ W T T + + A +G T I+ T+ T+TGL+ T Y+I + +++
Sbjct: 1829 TITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1888
Query: 99 AGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKE 158
RS + + A L + + +S+LV W+ I + I++ GS +E
Sbjct: 1889 NARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARI--TGYIIKYEKPGSPPRE 1946
Query: 159 NTTN-----TSLTFTSLEAGTLYTIKAYAWNANR 187
T T T LE GT YTI A N+
Sbjct: 1947 VVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
>gi|47132555 fibronectin 1 isoform 4 preproprotein [Homo sapiens]
Length = 2330
Score = 71.6 bits (174), Expect = 2e-12
Identities = 126/562 (22%), Positives = 207/562 (36%), Gaps = 49/562 (8%)
Query: 42 SNSITVEW----ATVPGATSYLLTAEDGDTVIETTVANSPG--TVTGLKAATWYEITIRS 95
+NS TV W AT+ G E V +S T+T L T Y ++I +
Sbjct: 1371 ANSFTVHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVA 1430
Query: 96 ISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
++ S +Q+ LEV + + S+L+ W+A + + + G S
Sbjct: 1431 LNGREESPLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSP 1490
Query: 156 WKENT---TNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDS------TCNQRTSPRAPAN 206
+E T + ++ T + L+ G YTI YA GD + N RT P+
Sbjct: 1491 VQEFTVPGSKSTATISGLKPGVDYTITVYAVTGR---GDSPASSKPISINYRTEIDKPSQ 1547
Query: 207 IQVSFDSGALKASFSWARAEG-AFNYTVMAL-----SDSSELTCSTTFSSCTISSLQCGT 260
+QV+ D S W + Y V + T + TI LQ
Sbjct: 1548 MQVT-DVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV 1606
Query: 261 EYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSV--DLGDYYVV 318
EY++SV A N +G S+ T T P + + + +AW S + Y V
Sbjct: 1607 EYVVSVYAQNPSGESQ-PLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVT 1665
Query: 319 FVKSDDGLE-----VHCNTSLTQCNFLSECGFTYFISVF-VYNKAGQSPLGDIFNYTTAP 372
+ +DG+ + L G Y +SV +++ PL I +TA
Sbjct: 1666 YSSPEDGIHELFPAPDGEEDTAELQGLRP-GSEYTVSVVALHDDMESQPL--IGTQSTAI 1722
Query: 373 CCPSDINPVLVSSDRVEIVWSP----VRGAELYETKAVDGYNMVECN--DTTPACTLSAL 426
P+D+ V+ + W+P + G + T M E N + + +S L
Sbjct: 1723 PAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGL 1782
Query: 427 ECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT 486
TKY ++VY+ + S + P V+ + I + WR+ + T
Sbjct: 1783 MVATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETIT 1842
Query: 487 ----YTVTAQGEKGLYQCSSTG-ESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLET 541
V A G+ + + S T+ GL G+ + + RS P + T
Sbjct: 1843 GFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSP-VVIDAST 1901
Query: 542 VPCCPTGLTVTQITQSVINVSW 563
P+ L T + + VSW
Sbjct: 1902 AIDAPSNLRFLATTPNSLLVSW 1923
Score = 64.3 bits (155), Expect = 4e-10
Identities = 84/346 (24%), Positives = 137/346 (39%), Gaps = 29/346 (8%)
Query: 249 SSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWS 308
+S T+++L GTEY++S++A N S TV+ P + + P L ++W
Sbjct: 1411 NSITLTNLTPGTEYVVSIVALNGREESPLLIGQQ-STVSDVPRDLEVVAATPTSLLISWD 1469
Query: 309 SVDLGDYYVVFVKSDDG-------LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSP 361
+ + Y + G V + S + L G Y I+V+ G SP
Sbjct: 1470 APAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP-GVDYTITVYAVTGRGDSP 1528
Query: 362 LGD---IFNYTTAPCCPSDINPVLVSSDRVEIVW----SPVRGAELYETKAVDGYNMVEC 414
NY T PS + V + + + W SPV G + T +G +
Sbjct: 1529 ASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPK-NGPGPTKT 1587
Query: 415 NDTTP---ACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAF 471
P T+ L+ +Y ++VY+ N G + +T + D
Sbjct: 1588 KTAGPDQTEMTIEGLQPTVEYVVSVYAQNP-SGESQPLVQTAVTNIDRPKGLAFTDVDVD 1646
Query: 472 SMINVHWRSTNDDAT-YTVT-AQGEKGLYQC--SSTGESCT--MRGLPCGSVFSVTAVAE 525
S I + W S + Y VT + E G+++ + GE T ++GL GS ++V+ VA
Sbjct: 1647 S-IKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVAL 1705
Query: 526 TQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQT 571
S P +P PT L TQ+T + ++ WT V T
Sbjct: 1706 HDDMESQPLIGTQSTAIPA-PTDLKFTQVTPTSLSAQWTPPNVQLT 1750
Score = 59.7 bits (143), Expect = 9e-09
Identities = 111/578 (19%), Positives = 216/578 (37%), Gaps = 49/578 (8%)
Query: 75 NSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQW- 133
N+ VTGL Y + ++S S+ +Q + A L+ + + ++LV+W
Sbjct: 959 NTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWT 1018
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGD 191
A +V + R G + + + +L+ + YT+ A N+
Sbjct: 1019 PPRAQITGYRLTVGLTR-RGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPK 1077
Query: 192 DS---TCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT- 247
+ T Q S P N +V+ + + +W A + S E T
Sbjct: 1078 ATGVFTTLQPGSSIPPYNTEVTETTIVI----TWTPAPRIGFKLGVRPSQGGEAPREVTS 1133
Query: 248 -FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDP-PGHLSV 305
S +S L G EY+ ++ D + + T P + ++ +P G L+V
Sbjct: 1134 DSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTV 1193
Query: 306 AW---SSVDLGDYYVVFVKSD----DGLEVHCNTSLTQCNFLS-ECGFTYFISVFVYNKA 357
+W ++ D+ Y + ++ + LE + + C F + G Y +SV+
Sbjct: 1194 SWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Query: 358 GQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYE-------TKAVDGY 409
+S P+ D P P+D+ + D + + W+P +L K +
Sbjct: 1254 KESVPISDTIIPAVPP--PTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDV 1311
Query: 410 NMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSN-MSCTPQFITTAPCSPEIKNVSR 468
+ + + A L+ L T+Y ++V S E S + + +P + +++
Sbjct: 1312 AELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITA 1371
Query: 469 DAFSMINVHWRSTNDDAT------YTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTA 522
++F+ VHW + T + G + + S T+ L G+ + V+
Sbjct: 1372 NSFT---VHWIAPRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSI 1428
Query: 523 VAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQTHVAVLESHTG- 581
VA S P TV P L V T + + +SW V + + TG
Sbjct: 1429 VALNGREES-PLLIGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGG 1487
Query: 582 -----QSKCHTHQNHCLLGCITCGINYTVTLKAISATG 614
+ ++ + + G++YT+T+ A++ G
Sbjct: 1488 NSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1525
Score = 56.2 bits (134), Expect = 1e-07
Identities = 90/374 (24%), Positives = 140/374 (37%), Gaps = 47/374 (12%)
Query: 241 ELTCSTTFSSCTISSLQCGTEY---LISV------------LASNDAGSSKSSSAMTLKT 285
E T +S TI L+ G Y LIS+ + + +S+ +T +T
Sbjct: 656 EATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET 715
Query: 286 VACAPGRVT---IQEDPPGHLSVAWSSVD--LGDYYVVFVKSDDGLE---VHCNTSLTQC 337
+P T + E V+W S + + V + S++G E + ++ T
Sbjct: 716 TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSV 775
Query: 338 NFLSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWS--- 393
N G Y ++V+ ++ G+ L + TTAP P D V + + WS
Sbjct: 776 NIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQ 835
Query: 394 -PVRGAELYETKAVDGYNMVECN--DTTPACTLSALECDTKYNITVYSFNEVRGSNMSCT 450
P+ G + + +V+G + E N +T + TLS L+ +YNIT+Y+ E + S
Sbjct: 836 APITGYRIVYSPSVEG-SSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVI 894
Query: 451 PQFITTAPCSPEIKNVSRDAF-----SMINVHWRSTNDDAT------YTVTAQGEKGLYQ 499
Q T P S + + F + + W T V GE G
Sbjct: 895 QQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRL 954
Query: 500 CSSTGESCTMRGLPCGSV--FSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQS 557
S + GL G F V AV+ GR + T PT L T S
Sbjct: 955 PISRNTFAEVTGLSPGVTYYFKVFAVSH---GRESKPLTAQQTTKLDAPTNLQFVNETDS 1011
Query: 558 VINVSWTIGRVAQT 571
+ V WT R T
Sbjct: 1012 TVLVRWTPPRAQIT 1025
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/462 (21%), Positives = 167/462 (36%), Gaps = 54/462 (11%)
Query: 21 MVASAKSAPEIPTIDQAYSKLSNSITVEWATVPGATSYLLTAEDGDT-----VIETTV-- 73
++ + ++P + + S+ + W P T G+T V E TV
Sbjct: 1440 LIGQQSTVSDVPRDLEVVAATPTSLLISW-DAPAVTVRYYRITYGETGGNSPVQEFTVPG 1498
Query: 74 ANSPGTVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAPI-LEVSSPSSDSI 129
+ S T++GLK Y IT+ +++ G S AS +T + P ++V+ +SI
Sbjct: 1499 SKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSI 1558
Query: 130 LVQW-EAVYMAIAFSVSIMRANGLGSIWKENT--TNTSLTFTSLEAGTLYTIKAYAWN-- 184
V+W + + V+ NG G + T +T L+ Y + YA N
Sbjct: 1559 SVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPS 1618
Query: 185 ANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFN-YTVMALSDSSEL- 242
P + P+ A V DS +W +G + Y V S +
Sbjct: 1619 GESQPLVQTAVTNIDRPKGLAFTDVDVDS----IKIAWESPQGQVSRYRVTYSSPEDGIH 1674
Query: 243 ----TCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQED 298
+ + L+ G+EY +SV+A +D S+ T T AP + +
Sbjct: 1675 ELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIG-TQSTAIPAPTDLKFTQV 1733
Query: 299 PPGHLSVAWS--SVDLGDYYV-VFVKSDDGLEVHCNTSLTQCNFLSE---CGFTYFISVF 352
P LS W+ +V L Y V V K G N + + + Y +SV+
Sbjct: 1734 TPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVY 1793
Query: 353 VYNKAGQS-PLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNM 411
S P + P + + I W +T+ + G+ +
Sbjct: 1794 ALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRT-------KTETITGFQV 1846
Query: 412 --VECNDTTP----------ACTLSALECDTKYNITVYSFNE 441
V N TP + T++ L+ T Y I +Y+ N+
Sbjct: 1847 DAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1888
Score = 41.2 bits (95), Expect = 0.003
Identities = 46/181 (25%), Positives = 78/181 (43%), Gaps = 13/181 (7%)
Query: 44 SITVEWAT-VPGATSYLLTA--EDGDTVIETTVANSPG--TVTGLKAATWYEITIRSISA 98
+IT+ W T T + + A +G T I+ T+ T+TGL+ T Y+I + +++
Sbjct: 1829 TITISWRTKTETITGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLND 1888
Query: 99 AGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKE 158
RS + + A L + + +S+LV W+ I + I++ GS +E
Sbjct: 1889 NARSSPVVIDASTAIDAPSNLRFLATTPNSLLVSWQPPRARI--TGYIIKYEKPGSPPRE 1946
Query: 159 NTTN-----TSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDS 213
T T T LE GT YTI A N+ + ++T + P +D+
Sbjct: 1947 VVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ-KSEPLIGRKKTVQKTPFVTHPGYDT 2005
Query: 214 G 214
G
Sbjct: 2006 G 2006
>gi|157384973 tenascin R [Homo sapiens]
Length = 1358
Score = 65.5 bits (158), Expect = 2e-10
Identities = 132/619 (21%), Positives = 227/619 (36%), Gaps = 77/619 (12%)
Query: 47 VEWATVPGATSYLLT------AEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAG 100
VEW ++L E G T S +V L+ + YE+++ ++
Sbjct: 522 VEWIPPRAKVDFILLKYGLVGGEGGRTTFRLQPPLSQYSVQALRPGSRYEVSVSAVRGTN 581
Query: 101 RSQASPPKQAKTVLAAPILEVSSPSSDSILVQWE----------AVYMAIAFSV--SIMR 148
S ++ + + A L V S ++ S+ ++W+ VY +A ++
Sbjct: 582 ESDSATTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEVQEYKVVYSTLAGEQYHEVLV 641
Query: 149 ANGLGSIWKENTTNTSLTFTSLEAGTLYT--IKAYAWNANRIPGDDSTCNQRTSPRAPAN 206
G+G T T T L GT Y I A + +P +T N RT +P +
Sbjct: 642 PRGIGP-------TTRATLTDLVPGTEYGVGISAVMNSQQSVP---ATMNARTELDSPRD 691
Query: 207 IQVSFDSGALKASFSWARAEGAFNYTVMALSDSS----ELTCSTTFSSCTISSLQCGTEY 262
+ V+ S S W +A G ++ + + SS E+T +S T++ L+ G EY
Sbjct: 692 LMVTASSET-SISLIWTKASGPIDHYRITFTPSSGIASEVTVPKDRTSYTLTDLEPGAEY 750
Query: 263 LISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVD-----LGDYYV 317
+ISV A S S+ T + +++ WS L Y
Sbjct: 751 IISVTAERGRQQSLESTVDAF-TGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYS 809
Query: 318 VFVKSDDGLEVHCNTSLTQCNFLSECGFTYFI--SVFVYNKAGQSPLGDIFNYTTAPCCP 375
+ ++ +EV + + + T +I V V+ P+ + + TT P
Sbjct: 810 PRDEEEEMMEVSLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPI--VGSITTGIDPP 867
Query: 376 SDINPVLVSSDRVEIVWS-PVRGAELYETK----AVDGYNMVECNDTTPACTLSALECDT 430
DI V+ D V + WS PV + Y V + +T T++ L T
Sbjct: 868 KDITISNVTKDSVMVSWSPPVASFDYYRVSYRPTQVGRLDSSVVPNTVTEFTITRLNPAT 927
Query: 431 KYNITVYSFNEVRG---SNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRS-TNDDAT 486
+Y I S N VRG S CT + TA +P + + + W++ +
Sbjct: 928 EYEI---SLNSVRGREESERICT--LVHTAMDNPVDLIATNITPTEALLQWKAPVGEVEN 982
Query: 487 YTVTAQGEKGLYQCSSTGESCTMRGLP--------CGSVFSVTAVAETQAGRSLPSYSVP 538
Y + L + GE+ + G+ S + T + + S
Sbjct: 983 YVIV------LTHFAVAGETILVDGVSEEFRLVDLLPSTHYTATMYATNGPLTSGTISTN 1036
Query: 539 LETVPCCPTGLTVTQITQSVINVSWTIGRV-AQTHVAVLESHTGQSK---CHTHQNHCLL 594
T+ P LT +++T+ +SW R + +V +S G K L
Sbjct: 1037 FSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTDGSRKELIVDAEDTWIRL 1096
Query: 595 GCITCGINYTVTLKAISAT 613
+ +YTV L+A T
Sbjct: 1097 EGLLENTDYTVLLQAAQDT 1115
Score = 52.0 bits (123), Expect = 2e-06
Identities = 114/557 (20%), Positives = 208/557 (37%), Gaps = 48/557 (8%)
Query: 44 SITVEWATVPGATSYLLTAED---GDTVIETTVAN--SPGTVTGLKAATWYEITIRSISA 98
SI +EW T Y+++ + G ++ V S T+T L+ Y I++ ++ +
Sbjct: 341 SIELEWDGPMAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVIS 400
Query: 99 AGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAI-AFSVSIMRANGLGSIWK 157
S K A + L+ + + ++ VQWE + + +S + N G +
Sbjct: 401 NILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFIPKNNEGGVIA 460
Query: 158 ENTTN-TSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGAL 216
+ ++ TS T L+ G Y + A + ++ + T P I V D
Sbjct: 461 QVPSDVTSFNQTGLKPGEEYIVNVVALK-EQARSPPTSASVSTVIDGPTQILVR-DVSDT 518
Query: 217 KASFSWARAEGAFNYTVMALSDSSELTCSTTF------SSCTISSLQCGTEYLISVLASN 270
A W ++ ++ TTF S ++ +L+ G+ Y +SV A
Sbjct: 519 VAFVEWIPPRAKVDFILLKYGLVGGEGGRTTFRLQPPLSQYSVQALRPGSRYEVSVSAVR 578
Query: 271 DAGSSKSSSAMT-LKTVACAPGRVTIQEDPPGHLSVAW--SSVDLGDYYVVF-------- 319
G+++S SA T T AP + + L + W S ++ +Y VV+
Sbjct: 579 --GTNESDSATTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEVQEYKVVYSTLAGEQY 636
Query: 320 --VKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSD 377
V G+ +LT G Y + + + QS + N T P D
Sbjct: 637 HEVLVPRGIGPTTRATLTDL----VPGTEYGVGISAVMNSQQS-VPATMNARTELDSPRD 691
Query: 378 INPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVECNDTTP----ACTLSALECDTKYN 433
+ S + ++W+ G + + + T P + TL+ LE +Y
Sbjct: 692 LMVTASSETSISLIWTKASGPIDHYRITFTPSSGIASEVTVPKDRTSYTLTDLEPGAEYI 751
Query: 434 ITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRSTNDDA-----TYT 488
I+V + + S S F P S + S S +N+ W + A Y+
Sbjct: 752 ISVTAERGRQQSLESTVDAFTGFRPISH--LHFSHVTSSSVNITWSDPSPPADRLILNYS 809
Query: 489 VTAQGEKGL-YQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPT 547
+ E+ + +T + GL + + V VA S P + T P
Sbjct: 810 PRDEEEEMMEVSLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVG-SITTGIDPPK 868
Query: 548 GLTVTQITQSVINVSWT 564
+T++ +T+ + VSW+
Sbjct: 869 DITISNVTKDSVMVSWS 885
Score = 42.0 bits (97), Expect = 0.002
Identities = 113/572 (19%), Positives = 215/572 (37%), Gaps = 43/572 (7%)
Query: 119 LEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKENTTN---TSLTFTSLEAGTL 175
L V+ S SI ++W+ MA+ V + LG + + + +T T LE G
Sbjct: 332 LRVAGISDRSIELEWDGP-MAVTEYVISYQPTALGGLQLQQRVPGDWSGVTITELEPGLT 390
Query: 176 YTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEGAFN-YTVM 234
Y I YA +N I T T P +Q + W +F+ + +
Sbjct: 391 YNISVYAVISN-ILSLPITAKVATHLSTPQGLQFKTIT-ETTVEVQWEPFSFSFDGWEIS 448
Query: 235 ALSDSSE----LTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAP 290
+ ++E + +S + L+ G EY+++V+A + S +SA ++ TV P
Sbjct: 449 FIPKNNEGGVIAQVPSDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSA-SVSTVIDGP 507
Query: 291 GRVTIQEDPPGHLSVAW----SSVDLGDYYVVFVKSDDG-LEVHCNTSLTQCNFLS-ECG 344
++ +++ V W + VD V + G L+Q + + G
Sbjct: 508 TQILVRDVSDTVAFVEWIPPRAKVDFILLKYGLVGGEGGRTTFRLQPPLSQYSVQALRPG 567
Query: 345 FTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRG-----AE 399
Y +SV +S +TT P ++ ++ +++ W
Sbjct: 568 SRYEVSVSAVRGTNESDSATT-QFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEVQEYKV 626
Query: 400 LYETKAVDGYNMV---ECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQF-IT 455
+Y T A + Y+ V T TL+ L T+Y + + + V S S
Sbjct: 627 VYSTLAGEQYHEVLVPRGIGPTTRATLTDLVPGTEYGVGI---SAVMNSQQSVPATMNAR 683
Query: 456 TAPCSPEIKNVSRDAFSMINVHW-RSTNDDATYTVTAQGEKGL---YQCSSTGESCTMRG 511
T SP V+ + + I++ W +++ Y +T G+ S T+
Sbjct: 684 TELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGIASEVTVPKDRTSYTLTD 743
Query: 512 LPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVAQT 571
L G+ + ++ AE +SL S +V T + L + +T S +N++W+
Sbjct: 744 LEPGAEYIISVTAERGRQQSLES-TVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPAD 802
Query: 572 HVAV------LESHTGQSKCHTHQNHCLLGCITCGINYTVTLKAISATGLTADCSYQSYF 625
+ + E + + H +L + Y V L A+ T +T++ S
Sbjct: 803 RLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATEYIVNLVAVHGT-VTSEPIVGSIT 861
Query: 626 SGACCPLGVKLYRLGPNGIRIYWQASRGSANY 657
+G P + + + + + + W S +Y
Sbjct: 862 TGIDPPKDITISNVTKDSVMVSWSPPVASFDY 893
Score = 35.4 bits (80), Expect = 0.19
Identities = 71/276 (25%), Positives = 110/276 (39%), Gaps = 26/276 (9%)
Query: 67 TVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-LEVSSPS 125
+V+ TV T+T L AT YEI++ S+ S+ T + P+ L ++ +
Sbjct: 909 SVVPNTVTEF--TITRLNPATEYEISLNSVRGREESERI-CTLVHTAMDNPVDLIATNIT 965
Query: 126 SDSILVQWEAVYMAIAFSVSIMRANGL-GSIWKENTTNTSLTFTSLEAGTLYTIKAYAWN 184
L+QW+A + V ++ + G + + L T YT YA N
Sbjct: 966 PTEALLQWKAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTATMYATN 1025
Query: 185 ANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSW--ARAEGAFNYTVMALS---DS 239
G ST N T PAN+ S + A SW RAE NY + S
Sbjct: 1026 GPLTSGTIST-NFSTLLDPPANLTAS-EVTRQSALISWQPPRAE-IENYVLTYKSTDGSR 1082
Query: 240 SELTCSTTFSSCTISSLQCGTEYLISVLASND-AGSSKSSSAMTLKTVACAPGRV-TIQE 297
EL + + L T+Y + + A+ D SS +S+A T GRV +
Sbjct: 1083 KELIVDAEDTWIRLEGLLENTDYTVLLQAAQDTTWSSITSTAFT------TGGRVFPHPQ 1136
Query: 298 DPPGHLSVAWSSVDLGDYYVVFVKSD--DGLEVHCN 331
D HL + L Y +F+ + L+V+C+
Sbjct: 1137 DCAQHL---MNGDTLSGVYPIFLNGELSQKLQVYCD 1169
Score = 31.2 bits (69), Expect = 3.6
Identities = 58/301 (19%), Positives = 108/301 (35%), Gaps = 24/301 (7%)
Query: 42 SNSITVEWATV-PGATSYLLTAEDGDTVIETTVANSPGT-----VTGLKAATWYEITIRS 95
S+S+ + W+ P A +L D E + T + GL+ AT Y + + +
Sbjct: 787 SSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVSLDATKRHAVLMGLQPATEYIVNLVA 846
Query: 96 ISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
+ S+ + + +S+ + DS++V W + + R +G +
Sbjct: 847 VHGTVTSEPIVGSITTGIDPPKDITISNVTKDSVMVSWSPPVASFDYYRVSYRPTQVGRL 906
Query: 156 WKENTTN--TSLTFTSLEAGTLYTIKAYAWNANRIPGDDST---CN-QRTSPRAPANIQV 209
N T T T L T Y I + N + G + + C T+ P ++ +
Sbjct: 907 DSSVVPNTVTEFTITRLNPATEYEI-----SLNSVRGREESERICTLVHTAMDNPVDL-I 960
Query: 210 SFDSGALKASFSWARAEGAFNYTVMALSD----SSELTCSTTFSSCTISSLQCGTEYLIS 265
+ + +A W G V+ L+ + + L T Y +
Sbjct: 961 ATNITPTEALLQWKAPVGEVENYVIVLTHFAVAGETILVDGVSEEFRLVDLLPSTHYTAT 1020
Query: 266 VLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLG-DYYVVFVKSDD 324
+ A+N +S + S T+ P +T E ++W + YV+ KS D
Sbjct: 1021 MYATNGPLTSGTIST-NFSTLLDPPANLTASEVTRQSALISWQPPRAEIENYVLTYKSTD 1079
Query: 325 G 325
G
Sbjct: 1080 G 1080
>gi|62988324 tenascin N [Homo sapiens]
Length = 1299
Score = 64.7 bits (156), Expect = 3e-10
Identities = 125/565 (22%), Positives = 196/565 (34%), Gaps = 68/565 (12%)
Query: 43 NSITVEWATVPGATSYLLTAED---GDTVIETTVANSPGT-----VTGLKAATWYEITIR 94
NS+ VEW Y G V E TV S +TGL T Y+IT+
Sbjct: 365 NSLDVEWENPSTEVDYYKLRYGPMTGQEVAEVTVPKSSDPKSRYDITGLHPGTEYKITV- 423
Query: 95 SISAAGRSQASPPKQAKTVLAAPILEVSSPSS--------DSILVQWEAVYMAI-AFSVS 145
+ G + P +L E+ SP++ D+ V W+ V I + V
Sbjct: 424 -VPMRGELEGKP------ILLNGRTEIDSPTNVVTDRVTEDTATVSWDPVQAVIDKYVVR 476
Query: 146 IMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPA 205
A+G + +S T L+ G Y + +A N+ + N T +PA
Sbjct: 477 YTSADGDTKEMAVHKDESSTVLTGLKPGEAYKVYVWAERGNQ-GSKKADTNALTEIDSPA 535
Query: 206 NIQVSFDSGALKASFSWARAEGAFN-----YTVMALSDSSELTCSTTFSSCTISSLQCGT 260
N+ V+ A+ SW + + YT ++ E+ SS ++ L+ G
Sbjct: 536 NL-VTDRVTENTATISWDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGV 594
Query: 261 EYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLG-DYYVVF 319
EY + V A SK + T +P + +V+W V D YVV
Sbjct: 595 EYTVHVWAQKGDRESKKADT-NAPTDIDSPKNLVTDRVTENMATVSWDPVQAAIDKYVVR 653
Query: 320 VKSDDG----LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCP 375
S G + V S T L G Y + V+ +S D T P
Sbjct: 654 YTSAGGETREVPVGKEQSSTVLTGLRP-GMEYMVHVWAQKGDQESKKADTKAQTDID-SP 711
Query: 376 SDINPVLVSSDRVEIVWSPVRGA----ELYETKAVDGYNM-VECNDTTPACTLSALECDT 430
++ V+ + + W PVR + T A DG V + L+ L
Sbjct: 712 QNLVTDRVTENMATVSWDPVRATIDRYVVRYTSAKDGETREVPVGKEQSSTVLTGLRPGV 771
Query: 431 KYNITVYSFNEVRGSNMSCT--------PQFITTAPCSPEIKNVSRD----AFSMINVHW 478
+Y + V++ + S + T PQ + T + VS D VH+
Sbjct: 772 EYTVHVWAQKGAQESKKADTKAQTDIDSPQNLVTDWVTENTATVSWDPVQATIDRYVVHY 831
Query: 479 RSTNDDATYTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVP 538
S N GE S + GL G ++V A+ + +
Sbjct: 832 TSAN----------GETREVPVGKEQSSTVLTGLRPGMEYTVHVWAQ-KGNQESKKADTK 880
Query: 539 LETVPCCPTGLTVTQITQSVINVSW 563
+T P L +T+++ VSW
Sbjct: 881 AQTEIDGPKNLVTDWVTENMATVSW 905
Score = 42.0 bits (97), Expect = 0.002
Identities = 78/372 (20%), Positives = 133/372 (35%), Gaps = 25/372 (6%)
Query: 43 NSITVEW----ATVPGATSYLLTAEDGDTVIETTVANSPGTV-TGLKAATWYEITIRSIS 97
N+ T+ W AT+ +A+D +T TV TGL+ Y + + +
Sbjct: 545 NTATISWDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGVEYTVHVWAQK 604
Query: 98 AAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWK 157
S+ + + + L + + V W+ V AI ++R G +
Sbjct: 605 GDRESKKADTNAPTDIDSPKNLVTDRVTENMATVSWDPVQAAI--DKYVVRYTSAGGETR 662
Query: 158 E---NTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSG 214
E +S T L G Y + +A ++ T Q T +P N+ +
Sbjct: 663 EVPVGKEQSSTVLTGLRPGMEYMVHVWAQKGDQESKKADTKAQ-TDIDSPQNLVTDRVTE 721
Query: 215 ALKASFSWARAEGAFN-----YTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLAS 269
+ A+ SW + YT ++ E+ SS ++ L+ G EY + V A
Sbjct: 722 NM-ATVSWDPVRATIDRYVVRYTSAKDGETREVPVGKEQSSTVLTGLRPGVEYTVHVWAQ 780
Query: 270 NDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLG-DYYVVFVKSDDG--- 325
A SK + +T +P + +V+W V D YVV S +G
Sbjct: 781 KGAQESKKADTKA-QTDIDSPQNLVTDWVTENTATVSWDPVQATIDRYVVHYTSANGETR 839
Query: 326 -LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVS 384
+ V S T L G Y + V+ +S D T P ++ V+
Sbjct: 840 EVPVGKEQSSTVLTGLRP-GMEYTVHVWAQKGNQESKKADTKAQTEID-GPKNLVTDWVT 897
Query: 385 SDRVEIVWSPVR 396
+ + W PV+
Sbjct: 898 ENMATVSWDPVQ 909
>gi|241896924 protein tyrosine phosphatase, receptor type, H isoform
1 precursor [Homo sapiens]
Length = 1115
Score = 64.3 bits (155), Expect = 4e-10
Identities = 98/432 (22%), Positives = 161/432 (37%), Gaps = 27/432 (6%)
Query: 153 GSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFD 212
G+ NTT T++T L G+LYT + + + T T+P N++V
Sbjct: 72 GTTETRNTTATNVTVDGLGPGSLYTCSVWV-EKDGVNSSVGTVTTATAPNPVRNLRVEAQ 130
Query: 213 SGALKASFSWARAEGA----FNYTVMALSDSSEL-TCSTTFSSCTISSLQCGTEYLISVL 267
+ + + +W +G Y V D T ST ++ T+ L+ G Y S+
Sbjct: 131 TNS-SIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEPGCLYAFSMW 189
Query: 268 ASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGD----YYVVFVKSD 323
+ G + S T + ++ +S++W D D Y V D
Sbjct: 190 VGKN-GINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNSTYCVQCTGD 248
Query: 324 DGLEVHCNTSLTQCNFLS-ECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVL 382
G NT+ T+ G Y SV+V K G + +I TAP ++
Sbjct: 249 GGRTETRNTTDTRVTVDGLGPGSLYTCSVWV-EKDGVNSSVEIVTSATAPNPVRNLTVEA 307
Query: 383 VSSDRVEIVWSPVRGAELYETK-----AVDGYNMVECNDTTPACTLSALECDTKYNITVY 437
++ + + W G + + DG + T+ LE Y +V+
Sbjct: 308 QTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVW 367
Query: 438 SFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRSTN----DDATYTVTAQG 493
G N S + TTAP ++ S I + W + D TY V G
Sbjct: 368 VGK--NGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTG 425
Query: 494 EKGLYQC-SSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVT 552
+ G + ++T S T L G++++ + AE R +V + TVP T L+
Sbjct: 426 DGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARG-SRQNVSISTVPNAVTSLSKQ 484
Query: 553 QITQSVINVSWT 564
T S I + WT
Sbjct: 485 DWTNSTIALRWT 496
Score = 49.3 bits (116), Expect = 1e-05
Identities = 62/273 (22%), Positives = 112/273 (41%), Gaps = 27/273 (9%)
Query: 39 SKLSNSITVEWATVPG-----ATSYLLTAEDGDTVIETTVANSPGTVTGLKAATWYEITI 93
++ ++SI + W G +T + DG + A++ TV L+ Y ++
Sbjct: 307 AQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSV 366
Query: 94 RSISAAGRSQASPPKQAKTVLAAPI----LEVSSPSSDSILVQWEAVYMAIA--FSVSIM 147
G++ + ++ + AP L + + ++ SI + WE ++ +
Sbjct: 367 W----VGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVE 422
Query: 148 RANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANI 207
G NTTNTS+T LE GTLYT +A N G + T P A ++
Sbjct: 423 YTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWA-EKNGARGSRQNVSISTVPNAVTSL 481
Query: 208 QVSFDSGALKASFSWARAEG----AFNYTVMALSD--SSELTCSTTFSSCTISSLQCGTE 261
D + W +G +++Y V + + + T ST+ + T+ L+ G+
Sbjct: 482 SKQ-DWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL 540
Query: 262 YLISVLASNDAGSSKSSSAMTLKTVACAPGRVT 294
Y ++V A + +S+ T A AP VT
Sbjct: 541 YHLTVWAERNEVRGYNSTL----TAATAPNEVT 569
>gi|205360934 fibronectin type III domain containing 3B [Homo sapiens]
Length = 1204
Score = 60.8 bits (146), Expect = 4e-09
Identities = 123/604 (20%), Positives = 227/604 (37%), Gaps = 90/604 (14%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATVPGAT-----SYLLTAED--GDTVIET--TVANSPGT 79
P++P+ + +T++W+ G + +Y L ++ D + T + T
Sbjct: 475 PQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
Query: 80 VTGLKAATWYEITIRSISAAGRSQAS-----------PPKQAKTVLAAPILEVSSPSSDS 128
V LK +T Y+ + + + G+S S P + ++ P+ +S
Sbjct: 535 VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPV------TSHG 588
Query: 129 ILVQWEAVY-----MAIAFSVSIMRANGLGSIWKE--NTTNTSLTFTSLEAGTLYTIKAY 181
V+W+ + + + I N + W+ + + T TFT L+ GTLY ++A
Sbjct: 589 FSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRAC 648
Query: 182 AWNANRIPGDDSTCNQ----RTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALS 237
+ G S C++ RT AP + G K + + + +S
Sbjct: 649 CIST----GGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVS 704
Query: 238 DSS-ELTCSTTFSS---------CTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVA 287
+ S E+T +S CT+ +L GT Y V A ND G S + T A
Sbjct: 705 EYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA 764
Query: 288 CAPGRV---TIQEDPPGHLSVAW-----SSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNF 339
PG+ I P G + V W S D+ +Y + + + ++ LE+ + + T+
Sbjct: 765 GPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEI 824
Query: 340 LSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGA 398
Y + +N+AG P ++ T P ++ + V + + A
Sbjct: 825 RDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSA 884
Query: 399 EL---YETKAVDGYNM----VECNDT------TPACTLSALECDTKYNITVYSFNEVRGS 445
L +E +G + ++ DT T + L +T Y I + + NE+
Sbjct: 885 CLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG 944
Query: 446 NMSCTPQFITT-----APCSPEIKNVSRDAFSMINVHWRSTN------DDATYTVTAQGE 494
S QFI P P ++ + S + + W +N +D YT+ +
Sbjct: 945 PFS---QFIKAKTRPLPPLPPRLECAAAGPQS-LKLKWGDSNSKTHAAEDIVYTLQLEDR 1000
Query: 495 KGLYQCSSTGESCT--MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVT 552
+ G S T ++ L + +S A ++AG S + T P +
Sbjct: 1001 NKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP 1060
Query: 553 QITQ 556
++TQ
Sbjct: 1061 RVTQ 1064
Score = 37.4 bits (85), Expect = 0.050
Identities = 82/417 (19%), Positives = 150/417 (35%), Gaps = 59/417 (14%)
Query: 251 CTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPG---RVTIQEDPPGHLSVAW 307
C + L+ T+Y + V A ++ S ++ T +CAP + L++ W
Sbjct: 340 CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQW 399
Query: 308 SS-VDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSE--CGFTYFISV--FVYNKAGQSPL 362
+ +D G ++ D E N+ QC F S+ C T + + A ++ +
Sbjct: 400 KAPIDNGSKITNYLLEWD--EGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
Query: 363 G------DIFNYT--TAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVEC 414
G ++ YT P PS V V + WS G E +
Sbjct: 458 GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDE 517
Query: 415 NDT---------TPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTA------PC 459
ND CT+ L+ T+Y + + N G + TT+ P
Sbjct: 518 NDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASN-TEGKSCPSEVLVCTTSPDRPGPPT 576
Query: 460 SPEIKN-VSRDAFSMINVHWRSTNDDATYTV--------TAQGEKGLYQCSSTGESC--T 508
P +K V+ FS V W D+ + E ++ + +G + T
Sbjct: 577 RPLVKGPVTSHGFS---VKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT 633
Query: 509 MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQI----TQSVINVSWT 564
L G+++ + A + G S S S+P+ T+ P ++ +++ W
Sbjct: 634 FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWD 693
Query: 565 IG------RVAQTHVAVLESHTGQSKC-HTHQNHCLLGCITCGINYTVTLKAISATG 614
+ V++ V + E S+ H + C +G + G Y ++A++ G
Sbjct: 694 VPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGG 750
>gi|205360932 fibronectin type III domain containing 3B [Homo sapiens]
Length = 1204
Score = 60.8 bits (146), Expect = 4e-09
Identities = 123/604 (20%), Positives = 227/604 (37%), Gaps = 90/604 (14%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATVPGAT-----SYLLTAED--GDTVIET--TVANSPGT 79
P++P+ + +T++W+ G + +Y L ++ D + T + T
Sbjct: 475 PQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCT 534
Query: 80 VTGLKAATWYEITIRSISAAGRSQAS-----------PPKQAKTVLAAPILEVSSPSSDS 128
V LK +T Y+ + + + G+S S P + ++ P+ +S
Sbjct: 535 VKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPV------TSHG 588
Query: 129 ILVQWEAVY-----MAIAFSVSIMRANGLGSIWKE--NTTNTSLTFTSLEAGTLYTIKAY 181
V+W+ + + + I N + W+ + + T TFT L+ GTLY ++A
Sbjct: 589 FSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRAC 648
Query: 182 AWNANRIPGDDSTCNQ----RTSPRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALS 237
+ G S C++ RT AP + G K + + + +S
Sbjct: 649 CIST----GGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVS 704
Query: 238 DSS-ELTCSTTFSS---------CTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVA 287
+ S E+T +S CT+ +L GT Y V A ND G S + T A
Sbjct: 705 EYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAA 764
Query: 288 CAPGRV---TIQEDPPGHLSVAW-----SSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNF 339
PG+ I P G + V W S D+ +Y + + + ++ LE+ + + T+
Sbjct: 765 GPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEI 824
Query: 340 LSEC-GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGA 398
Y + +N+AG P ++ T P ++ + V + + A
Sbjct: 825 RDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSA 884
Query: 399 EL---YETKAVDGYNM----VECNDT------TPACTLSALECDTKYNITVYSFNEVRGS 445
L +E +G + ++ DT T + L +T Y I + + NE+
Sbjct: 885 CLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAG 944
Query: 446 NMSCTPQFITT-----APCSPEIKNVSRDAFSMINVHWRSTN------DDATYTVTAQGE 494
S QFI P P ++ + S + + W +N +D YT+ +
Sbjct: 945 PFS---QFIKAKTRPLPPLPPRLECAAAGPQS-LKLKWGDSNSKTHAAEDIVYTLQLEDR 1000
Query: 495 KGLYQCSSTGESCT--MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVT 552
+ G S T ++ L + +S A ++AG S + T P +
Sbjct: 1001 NKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP 1060
Query: 553 QITQ 556
++TQ
Sbjct: 1061 RVTQ 1064
Score = 37.4 bits (85), Expect = 0.050
Identities = 82/417 (19%), Positives = 150/417 (35%), Gaps = 59/417 (14%)
Query: 251 CTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPG---RVTIQEDPPGHLSVAW 307
C + L+ T+Y + V A ++ S ++ T +CAP + L++ W
Sbjct: 340 CNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQW 399
Query: 308 SS-VDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSE--CGFTYFISV--FVYNKAGQSPL 362
+ +D G ++ D E N+ QC F S+ C T + + A ++ +
Sbjct: 400 KAPIDNGSKITNYLLEWD--EGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDI 457
Query: 363 G------DIFNYT--TAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVEC 414
G ++ YT P PS V V + WS G E +
Sbjct: 458 GTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDE 517
Query: 415 NDT---------TPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTA------PC 459
ND CT+ L+ T+Y + + N G + TT+ P
Sbjct: 518 NDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASN-TEGKSCPSEVLVCTTSPDRPGPPT 576
Query: 460 SPEIKN-VSRDAFSMINVHWRSTNDDATYTV--------TAQGEKGLYQCSSTGESC--T 508
P +K V+ FS V W D+ + E ++ + +G + T
Sbjct: 577 RPLVKGPVTSHGFS---VKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT 633
Query: 509 MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQI----TQSVINVSWT 564
L G+++ + A + G S S S+P+ T+ P ++ +++ W
Sbjct: 634 FTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWD 693
Query: 565 IG------RVAQTHVAVLESHTGQSKC-HTHQNHCLLGCITCGINYTVTLKAISATG 614
+ V++ V + E S+ H + C +G + G Y ++A++ G
Sbjct: 694 VPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGG 750
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 58.5 bits (140), Expect = 2e-08
Identities = 142/667 (21%), Positives = 254/667 (38%), Gaps = 68/667 (10%)
Query: 44 SITVEWAT-VPGATSYLLTAEDGDTVIETTVANSPG---TVTGLKAATWYEITIRSISAA 99
S+++ W T V Y+++ D D ++ + T T L Y T+ SIS
Sbjct: 700 SLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGD 759
Query: 100 GRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAF-SVSIMRANGLGSIWKE 158
++ +S + + + + S+ W + F V ++ N +
Sbjct: 760 LKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESI 819
Query: 159 NTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKA 218
++ + +F SL++G+LY++ + I RT P + + + V+
Sbjct: 820 SSETSRYSFHSLKSGSLYSVVVTTVSGG-ISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL 878
Query: 219 SFSWARAEGAF-NYTVMALSDSS---ELTCSTTFSSCTISSLQCGTEYLISVLASNDAGS 274
S SW A G NY V D L + + C+ SSL G Y +++ + +G
Sbjct: 879 SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTI--TTRSGK 936
Query: 275 SKSSSAMTLKTVACAPGRVTIQEDPPG-HLSVAW--SSVDLGDYYVVFVKSDDGLEVHCN 331
++ S +TV V++ +L V+W ++ D D+Y V +K+ + +
Sbjct: 937 YENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKS 995
Query: 332 TSLTQCNFLSECGFTYFI-----SVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSD 386
++ +EC F + SV V K+GQ + N T P D+ S++
Sbjct: 996 IPKSE----NECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTE 1051
Query: 387 RVEIVWSPVRG-AELYE-------TKAVDGYNMVECNDTTPACTLSALECDTKYNITVYS 438
+ + WS G + YE K +++V +T ++L +Y I V +
Sbjct: 1052 DLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLV---NTATEYRFTSLTPGRQYKILVLT 1108
Query: 439 FN-EVRGSNMSCTPQFITTAPCSPEIKNV---SRDAFSMINVHWRSTNDDA-TYTVTAQG 493
+ +V+ S FI +KN+ A + V+W D +YTV+A
Sbjct: 1109 ISGDVQQS------AFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFR 1162
Query: 494 EKGLYQCSSTGESC---TMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLT 550
+ + T L G + + + + +G +V TVP G+
Sbjct: 1163 HSQKVDSQTIPKHVFEHTFHRLEAGEQYQI--MIASVSGSLKNQINVVGRTVPASVQGVI 1220
Query: 551 VTQITQSV-INVSW-TIGRVAQTHVAVLESHTG-----QSKCHTHQNHCLLGCITCGINY 603
S + VSW VA+ + +L + G S+ T + H +T G Y
Sbjct: 1221 ADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQH-KFEDLTPGKKY 1279
Query: 604 TVTLKAISATGLTADCSYQSYFSGACCPLGVKLYRLGPNGIR---IYWQASRGSAN-YST 659
+ + +S GL S ++ G P V R+ N R W AS G + Y+
Sbjct: 1280 KIQILTVSG-GL---FSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNI 1335
Query: 660 DLYGSKG 666
LY G
Sbjct: 1336 FLYNPDG 1342
Score = 44.3 bits (103), Expect = 4e-04
Identities = 150/707 (21%), Positives = 258/707 (36%), Gaps = 83/707 (11%)
Query: 42 SNSITVEWATVPG-ATSYLLTAED-------GDTVIETTVANSPGTVTGLKAATWYEITI 93
S S+ V W G TSY + D G + E+T N T L A + Y I I
Sbjct: 343 STSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEY-TFFNLTAGSKYNIAI 401
Query: 94 RSISAAGRSQASPPKQAKTVLAAPILEVS-SPSSDSILVQWEAVYMAIAFSVSIMRANGL 152
++S RS S TV +P+ ++ S ++S+L+ W + ++ G+
Sbjct: 402 TAVSGGKRS-FSVYTNGSTV-PSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGI 459
Query: 153 ---GSIWKENTTNTSLTFTSLEAGTLYTIKA---------YAWNANRIPGDDSTCNQRTS 200
G + ++ T S F L G LY + Y W RT+
Sbjct: 460 LVHGGVVDKHAT--SYAFHGLTPGYLYNLTVMTEAAGLQNYRWKL-----------VRTA 506
Query: 201 PRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT----FSSCTISSL 256
P +N++V+ D W R G + + LS + S + L
Sbjct: 507 PMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKEL 566
Query: 257 QCGTEYLISV-LASNDAGSSKSSSAMTLKTVACAPGRV-TIQEDPPGH---LSVAWSSVD 311
G Y ++V S + + K + T P +V ++ + G L V+WS
Sbjct: 567 VPGRLYQVTVSCVSGELSAQKMAVGRTF------PDKVANLEANNNGRMRSLVVSWSP-P 619
Query: 312 LGDY--YVVFVKSDDGLEVHCNTSLTQCNFLSE-----CGFTYFISVFVYNKAGQSPLGD 364
GD+ Y + + +D + ++ + ++ + G Y + V V ++G +
Sbjct: 620 AGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIV--ESGNLKNSE 677
Query: 365 IFNYTTAPCCPSDINPVLVSSDRVEIVW-SPVRGAELYETKAVDGYNMV---ECNDTTPA 420
T P + + + I+W +PV E Y D ++ +
Sbjct: 678 RCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKE 737
Query: 421 CTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRS 480
T + L KY TV S + ++ S + + + N + S + +W
Sbjct: 738 FTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVAN--QGMTSSLFTNWTQ 795
Query: 481 TNDDAT-YTVTAQGEKGLYQ---CSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYS 536
D Y V E + + SS + L GS++SV V G S
Sbjct: 796 AQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 854
Query: 537 VPLETVPCCPTGLTVTQITQS-VINVSWTIGRVAQTHVAVLESHTG---QSKCHTHQ-NH 591
V TVP +G+TV ++ ++VSW + + V SH G QS
Sbjct: 855 VEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRE 914
Query: 592 CLLGCITCGINYTVTLKAISATGLTADCSYQSYFSGACCPLGVKLYRLGPNG-IRIYWQA 650
C +T G YTVT+ + +G + S+ + GV + + +R+ W
Sbjct: 915 CSFSSLTPGRLYTVTI--TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVH 972
Query: 651 SRGSANYSTDLYGSKGIFTCTPSAGLS--FCDVTEIPCGDVYTVMVS 695
+ G ++ +K F T S S C ++ G +Y+V V+
Sbjct: 973 ATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVT 1019
Score = 44.3 bits (103), Expect = 4e-04
Identities = 47/202 (23%), Positives = 90/202 (44%), Gaps = 20/202 (9%)
Query: 42 SNSITVEWATVPG-ATSYLLTA------EDGDTVIETTVANSPGTVTGLKAATWYEITIR 94
++S+TV W G SY ++A D T+ + + T L+A Y+I I
Sbjct: 1139 TDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---TFHRLEAGEQYQIMIA 1195
Query: 95 SISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWE-AVYMAIAFSVSIMRANGLG 153
S+S + ++Q + + ++ ++ SS S++V W+ A +A + + ++ NG
Sbjct: 1196 SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENG-- 1253
Query: 154 SIWKENTTNTSLT----FTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQV 209
I NT+ + T F L G Y I+ + + T RT P A ++++
Sbjct: 1254 -ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQT-EGRTVPAAVTDLRI 1311
Query: 210 SFDSGALKASFSWARAEGAFNY 231
+ ++ SF W +EG ++
Sbjct: 1312 T-ENSTRHLSFRWTASEGELSW 1332
Score = 36.2 bits (82), Expect = 0.11
Identities = 47/198 (23%), Positives = 78/198 (39%), Gaps = 24/198 (12%)
Query: 384 SSDRVEIVW----SPVRGAELYETKAVDGY--NMVECNDTTPACTLSALECDTKYNITVY 437
SS V I W SP + +Y + + ++TT C L L+ T YN +
Sbjct: 255 SSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRII 314
Query: 438 SFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVH--WRSTNDDAT-YTVTAQGE 494
S +E R + T P P VS++ + ++H W ++ T Y V E
Sbjct: 315 SLDEER-------TVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDE 367
Query: 495 KG------LYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTG 548
Q S++ T L GS +++ A + RS Y+ TVP
Sbjct: 368 NNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNG-STVPSPVKD 426
Query: 549 LTVTQITQSVINVSWTIG 566
+ ++ S++ +SW+ G
Sbjct: 427 IGISTKANSLL-ISWSHG 443
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 58.5 bits (140), Expect = 2e-08
Identities = 142/667 (21%), Positives = 254/667 (38%), Gaps = 68/667 (10%)
Query: 44 SITVEWAT-VPGATSYLLTAEDGDTVIETTVANSPG---TVTGLKAATWYEITIRSISAA 99
S+++ W T V Y+++ D D ++ + T T L Y T+ SIS
Sbjct: 482 SLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISGD 541
Query: 100 GRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWEAVYMAIAF-SVSIMRANGLGSIWKE 158
++ +S + + + + S+ W + F V ++ N +
Sbjct: 542 LKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNESI 601
Query: 159 NTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKA 218
++ + +F SL++G+LY++ + I RT P + + + V+
Sbjct: 602 SSETSRYSFHSLKSGSLYSVVVTTVSGG-ISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL 660
Query: 219 SFSWARAEGAF-NYTVMALSDSS---ELTCSTTFSSCTISSLQCGTEYLISVLASNDAGS 274
S SW A G NY V D L + + C+ SSL G Y +++ + +G
Sbjct: 661 SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTI--TTRSGK 718
Query: 275 SKSSSAMTLKTVACAPGRVTIQEDPPG-HLSVAW--SSVDLGDYYVVFVKSDDGLEVHCN 331
++ S +TV V++ +L V+W ++ D D+Y V +K+ + +
Sbjct: 719 YENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDF-DHYEVTIKNKNNFIQTKS 777
Query: 332 TSLTQCNFLSECGFTYFI-----SVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSD 386
++ +EC F + SV V K+GQ + N T P D+ S++
Sbjct: 778 IPKSE----NECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTE 833
Query: 387 RVEIVWSPVRG-AELYE-------TKAVDGYNMVECNDTTPACTLSALECDTKYNITVYS 438
+ + WS G + YE K +++V +T ++L +Y I V +
Sbjct: 834 DLHVTWSGANGDVDQYEIQLLFNDMKVFPPFHLV---NTATEYRFTSLTPGRQYKILVLT 890
Query: 439 FN-EVRGSNMSCTPQFITTAPCSPEIKNV---SRDAFSMINVHWRSTNDDA-TYTVTAQG 493
+ +V+ S FI +KN+ A + V+W D +YTV+A
Sbjct: 891 ISGDVQQS------AFIEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFR 944
Query: 494 EKGLYQCSSTGESC---TMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLT 550
+ + T L G + + + + +G +V TVP G+
Sbjct: 945 HSQKVDSQTIPKHVFEHTFHRLEAGEQYQI--MIASVSGSLKNQINVVGRTVPASVQGVI 1002
Query: 551 VTQITQSV-INVSW-TIGRVAQTHVAVLESHTG-----QSKCHTHQNHCLLGCITCGINY 603
S + VSW VA+ + +L + G S+ T + H +T G Y
Sbjct: 1003 ADNAYSSYSLIVSWQKAAGVAERYDILLLTENGILLRNTSEPATTKQH-KFEDLTPGKKY 1061
Query: 604 TVTLKAISATGLTADCSYQSYFSGACCPLGVKLYRLGPNGIR---IYWQASRGSAN-YST 659
+ + +S GL S ++ G P V R+ N R W AS G + Y+
Sbjct: 1062 KIQILTVSG-GL---FSKEAQTEGRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNI 1117
Query: 660 DLYGSKG 666
LY G
Sbjct: 1118 FLYNPDG 1124
Score = 44.3 bits (103), Expect = 4e-04
Identities = 150/707 (21%), Positives = 258/707 (36%), Gaps = 83/707 (11%)
Query: 42 SNSITVEWATVPG-ATSYLLTAED-------GDTVIETTVANSPGTVTGLKAATWYEITI 93
S S+ V W G TSY + D G + E+T N T L A + Y I I
Sbjct: 125 STSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEY-TFFNLTAGSKYNIAI 183
Query: 94 RSISAAGRSQASPPKQAKTVLAAPILEVS-SPSSDSILVQWEAVYMAIAFSVSIMRANGL 152
++S RS S TV +P+ ++ S ++S+L+ W + ++ G+
Sbjct: 184 TAVSGGKRS-FSVYTNGSTV-PSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKGI 241
Query: 153 ---GSIWKENTTNTSLTFTSLEAGTLYTIKA---------YAWNANRIPGDDSTCNQRTS 200
G + ++ T S F L G LY + Y W RT+
Sbjct: 242 LVHGGVVDKHAT--SYAFHGLTPGYLYNLTVMTEAAGLQNYRWKL-----------VRTA 288
Query: 201 PRAPANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTT----FSSCTISSL 256
P +N++V+ D W R G + + LS + S + L
Sbjct: 289 PMEVSNLKVTNDGSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKEL 348
Query: 257 QCGTEYLISV-LASNDAGSSKSSSAMTLKTVACAPGRV-TIQEDPPGH---LSVAWSSVD 311
G Y ++V S + + K + T P +V ++ + G L V+WS
Sbjct: 349 VPGRLYQVTVSCVSGELSAQKMAVGRTF------PDKVANLEANNNGRMRSLVVSWSP-P 401
Query: 312 LGDY--YVVFVKSDDGLEVHCNTSLTQCNFLSE-----CGFTYFISVFVYNKAGQSPLGD 364
GD+ Y + + +D + ++ + ++ + G Y + V V ++G +
Sbjct: 402 AGDWEQYRILLFNDSVVLLNITVGKEETQYVMDDTGLVPGRQYEVEVIV--ESGNLKNSE 459
Query: 365 IFNYTTAPCCPSDINPVLVSSDRVEIVW-SPVRGAELYETKAVDGYNMV---ECNDTTPA 420
T P + + + I+W +PV E Y D ++ +
Sbjct: 460 RCQGRTVPLAVLQLRVKHANETSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKE 519
Query: 421 CTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHWRS 480
T + L KY TV S + ++ S + + + N + S + +W
Sbjct: 520 FTFTDLVPGRKYMATVTSISGDLKNSSSVKGRTVPAQVTDLHVAN--QGMTSSLFTNWTQ 577
Query: 481 TNDDAT-YTVTAQGEKGLYQ---CSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYS 536
D Y V E + + SS + L GS++SV V G S
Sbjct: 578 AQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSV-VVTTVSGGISSRQVV 636
Query: 537 VPLETVPCCPTGLTVTQITQS-VINVSWTIGRVAQTHVAVLESHTG---QSKCHTHQ-NH 591
V TVP +G+TV ++ ++VSW + + V SH G QS
Sbjct: 637 VEGRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRE 696
Query: 592 CLLGCITCGINYTVTLKAISATGLTADCSYQSYFSGACCPLGVKLYRLGPNG-IRIYWQA 650
C +T G YTVT+ + +G + S+ + GV + + +R+ W
Sbjct: 697 CSFSSLTPGRLYTVTI--TTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVH 754
Query: 651 SRGSANYSTDLYGSKGIFTCTPSAGLS--FCDVTEIPCGDVYTVMVS 695
+ G ++ +K F T S S C ++ G +Y+V V+
Sbjct: 755 ATGDFDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVT 801
Score = 44.3 bits (103), Expect = 4e-04
Identities = 47/202 (23%), Positives = 90/202 (44%), Gaps = 20/202 (9%)
Query: 42 SNSITVEWATVPG-ATSYLLTA------EDGDTVIETTVANSPGTVTGLKAATWYEITIR 94
++S+TV W G SY ++A D T+ + + T L+A Y+I I
Sbjct: 921 TDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFEH---TFHRLEAGEQYQIMIA 977
Query: 95 SISAAGRSQASPPKQAKTVLAAPILEVSSPSSDSILVQWE-AVYMAIAFSVSIMRANGLG 153
S+S + ++Q + + ++ ++ SS S++V W+ A +A + + ++ NG
Sbjct: 978 SVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAAGVAERYDILLLTENG-- 1035
Query: 154 SIWKENTTNTSLT----FTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQV 209
I NT+ + T F L G Y I+ + + T RT P A ++++
Sbjct: 1036 -ILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQT-EGRTVPAAVTDLRI 1093
Query: 210 SFDSGALKASFSWARAEGAFNY 231
+ ++ SF W +EG ++
Sbjct: 1094 T-ENSTRHLSFRWTASEGELSW 1114
Score = 36.2 bits (82), Expect = 0.11
Identities = 47/198 (23%), Positives = 78/198 (39%), Gaps = 24/198 (12%)
Query: 384 SSDRVEIVW----SPVRGAELYETKAVDGY--NMVECNDTTPACTLSALECDTKYNITVY 437
SS V I W SP + +Y + + ++TT C L L+ T YN +
Sbjct: 37 SSHSVSIQWRILGSPCNFSLIYSSDTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRII 96
Query: 438 SFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVH--WRSTNDDAT-YTVTAQGE 494
S +E R + T P P VS++ + ++H W ++ T Y V E
Sbjct: 97 SLDEER-------TVVLQTDPLPPARFGVSKEKTTSTSLHVWWTPSSGKVTSYEVQLFDE 149
Query: 495 KG------LYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTG 548
Q S++ T L GS +++ A + RS Y+ TVP
Sbjct: 150 NNQKIQGVQIQESTSWNEYTFFNLTAGSKYNIAITAVSGGKRSFSVYTNG-STVPSPVKD 208
Query: 549 LTVTQITQSVINVSWTIG 566
+ ++ S++ +SW+ G
Sbjct: 209 IGISTKANSLL-ISWSHG 225
>gi|112734845 collagen, type XX, alpha 1 [Homo sapiens]
Length = 1284
Score = 54.3 bits (129), Expect = 4e-07
Identities = 69/284 (24%), Positives = 115/284 (40%), Gaps = 22/284 (7%)
Query: 44 SITVEWATVPGATSYLLTAEDG-----DTVIETTVANSPGTVTGLKAATWYEITIRSISA 98
++ + W GAT YL+ + E V + GL+ YE++++S+
Sbjct: 482 TVHLTWQPSAGATHYLVRCSPASPKGEEEEREVQVGRPEVLLDGLEPGRDYEVSVQSLRG 541
Query: 99 AGRSQASPPKQAKTVLAAP-ILEVSSPSSDSILVQWEAVYMAIAF-SVSIMRANGLGSIW 156
S+A + LA P L S S D+ V WE + V+ + + G S
Sbjct: 542 PEGSEARGIRARTPTLAPPRHLGFSDVSHDAARVFWEGAPRPVRLVRVTYVSSEGGHSGQ 601
Query: 157 KENTTN-TSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQR-TSPRAPANIQVS---F 211
E N TS T L + T YT++ G ST R T+ +AP+ Q+S
Sbjct: 602 TEAPGNATSATLGPLSSSTTYTVRVTCLYPG---GGSSTLTGRVTTKKAPSPSQLSMTEL 658
Query: 212 DSGALKASFSWARAEGAFNY----TVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVL 267
A++ ++ A G Y T + + E++ + + L TEY +++L
Sbjct: 659 PGDAVQLAWVAAAPSGVLVYQITWTPLGEGKAHEISVPGNLGTAVLPGLGRHTEYDVTIL 718
Query: 268 A--SNDAGSSKSSSAMTLKTVA-CAPGRVTIQEDPPGHLSVAWS 308
A + A S S T TV+ P + + + P L V+W+
Sbjct: 719 AYYRDGARSDPVSLRYTPSTVSRSPPSNLALASETPDSLQVSWT 762
Score = 44.3 bits (103), Expect = 4e-04
Identities = 85/391 (21%), Positives = 137/391 (35%), Gaps = 26/391 (6%)
Query: 249 SSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWS 308
+S + +L TEYL+SV + G + + P +T+ P + + W
Sbjct: 429 ASTELHNLASRTEYLVSVFPIYEGGVGEGLRGLVTTAPLPPPRALTLAAVTPRTVHLTWQ 488
Query: 309 SVDLGDYYVVFVK--SDDGLEVHCNTSLTQCNFL---SECGFTYFISVFVYNKAGQSPLG 363
+Y+V S G E + + L E G Y +SV S
Sbjct: 489 PSAGATHYLVRCSPASPKGEEEEREVQVGRPEVLLDGLEPGRDYEVSVQSLRGPEGSEAR 548
Query: 364 DIFNYTTAPCCPSDINPVLVSSDRVEIVWS----PVRGAELYETKAVDGYN-MVECNDTT 418
I T P + VS D + W PVR + + G++ E
Sbjct: 549 GIRARTPTLAPPRHLGFSDVSHDAARVFWEGAPRPVRLVRVTYVSSEGGHSGQTEAPGNA 608
Query: 419 PACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINVHW 478
+ TL L T Y + V GS+ + T + T SP +++ + + W
Sbjct: 609 TSATLGPLSSSTTYTVRVTCLYPGGGSS-TLTGRVTTKKAPSPSQLSMTELPGDAVQLAW 667
Query: 479 RSTNDDAT----YTVTAQGEKGLYQCSSTGE--SCTMRGLPCGSVFSVTAVAETQAGRSL 532
+ T T GE ++ S G + + GL + + VT +A + G
Sbjct: 668 VAAAPSGVLVYQITWTPLGEGKAHEISVPGNLGTAVLPGLGRHTEYDVTILAYYRDGARS 727
Query: 533 PSYSV---PLETVPCCPTGLTVTQITQSVINVSWT--IGRVAQTHVAVL-ESHTGQSKCH 586
S+ P P+ L + T + VSWT +GRV + S G K
Sbjct: 728 DPVSLRYTPSTVSRSPPSNLALASETPDSLQVSWTPPLGRVLHYWLTYAPASGLGPEKSV 787
Query: 587 T---HQNHCLLGCITCGINYTVTLKAISATG 614
+ ++H L + Y V + AI A G
Sbjct: 788 SVPGARSHVTLPDLQAATKYRVLVSAIYAAG 818
Score = 32.3 bits (72), Expect = 1.6
Identities = 31/142 (21%), Positives = 53/142 (37%), Gaps = 24/142 (16%)
Query: 530 RSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWT--------------IGRVAQTHVAV 575
R P+ + L+T+P PT L ++Q+T S I +SWT R V
Sbjct: 365 RQGPAAAPALDTLPA-PTSLVLSQVTSSSIRLSWTPAPRHPLKYLIVWRASRGGTPREVV 423
Query: 576 LESHTGQSKCHTHQNHCLLGCITCGINYTVTLKAISATGLTADCSYQSYFSGACCPLGVK 635
+E ++ H + Y V++ I G+ + P +
Sbjct: 424 VEGPAASTELHN---------LASRTEYLVSVFPIYEGGVGEGLRGLVTTAPLPPPRALT 474
Query: 636 LYRLGPNGIRIYWQASRGSANY 657
L + P + + WQ S G+ +Y
Sbjct: 475 LAAVTPRTVHLTWQPSAGATHY 496
Score = 31.2 bits (69), Expect = 3.6
Identities = 59/283 (20%), Positives = 108/283 (38%), Gaps = 36/283 (12%)
Query: 390 IVWSPVRGAELYETKAVDGYNMVECNDTTPACT--LSALECDTKYNITVYSFNEVRGSNM 447
IVW RG E V+G PA + L L T+Y ++V+ E G
Sbjct: 409 IVWRASRGGTPREV-VVEG----------PAASTELHNLASRTEYLVSVFPIYE--GGVG 455
Query: 448 SCTPQFITTAPCSPEIKNVSRDAFSMINVH--WRSTNDDATYTV-----TAQGEKGLYQC 500
+TTAP P + ++ A + VH W+ + Y V + +GE+ +
Sbjct: 456 EGLRGLVTTAPLPPP-RALTLAAVTPRTVHLTWQPSAGATHYLVRCSPASPKGEEEEREV 514
Query: 501 SSTGESCTMRGLPCGSVFSVTAVA----ETQAGRSLPSYSVPLETVPCCPTGLTVTQITQ 556
+ GL G + V+ + E R + + + L P L + ++
Sbjct: 515 QVGRPEVLLDGLEPGRDYEVSVQSLRGPEGSEARGIRARTPTLAP----PRHLGFSDVSH 570
Query: 557 SVINVSWT-----IGRVAQTHVAVLESHTGQSKCHTHQNHCLLGCITCGINYTVTLKAIS 611
V W + V T+V+ H+GQ++ + LG ++ YTV + +
Sbjct: 571 DAARVFWEGAPRPVRLVRVTYVSSEGGHSGQTEAPGNATSATLGPLSSSTTYTVRVTCLY 630
Query: 612 ATGLTADCSYQSYFSGACCPLGVKLYRLGPNGIRIYWQASRGS 654
G ++ + + A P + + L + +++ W A+ S
Sbjct: 631 PGGGSSTLTGRVTTKKAPSPSQLSMTELPGDAVQLAWVAAAPS 673
Score = 30.8 bits (68), Expect = 4.7
Identities = 23/72 (31%), Positives = 34/72 (47%), Gaps = 6/72 (8%)
Query: 39 SKLSNSITVEWATVPGAT-SYLLTAEDGDTVIETTVANSPG-----TVTGLKAATWYEIT 92
S+ +S+ V W G Y LT + + PG T+ L+AAT Y +
Sbjct: 751 SETPDSLQVSWTPPLGRVLHYWLTYAPASGLGPEKSVSVPGARSHVTLPDLQAATKYRVL 810
Query: 93 IRSISAAGRSQA 104
+ +I AAGRS+A
Sbjct: 811 VSAIYAAGRSEA 822
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 53.9 bits (128), Expect = 5e-07
Identities = 101/504 (20%), Positives = 185/504 (36%), Gaps = 89/504 (17%)
Query: 42 SNSITVEWAT--VPGAT----SYLLTAEDGDTVIETTVAN--SPGTVTGLKAATWYEITI 93
S+ + ++W+ +PG S+ + + DT+ ++ + + GL+ + Y I +
Sbjct: 1256 SDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRV 1315
Query: 94 RSISAAGR-SQASPPKQAKTVLAAPI----LEVSSPSSDSILVQWEAVYMAIAFSVSIMR 148
+ + G +Q S + T + P ++ + S S+LV+W+ A M
Sbjct: 1316 SAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV 1375
Query: 149 ANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCN----QRTSPRAP 204
S K + + TF L A T Y K A + + GD+STC+ T P P
Sbjct: 1376 TVERNST-KVSPQDHMYTFIKLLANTSYVFKVRA-STSAGEGDESTCHVSTLPETVPSVP 1433
Query: 205 ANIQVSFDSGALKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSC------------- 251
NI S D + A+ +W R + T++ + ++T C
Sbjct: 1434 TNIAFS-DVQSTSATLTWIRPD-----TILGYFQNYKITTQLRAQKCKEWESEECVEYQK 1487
Query: 252 ------------TISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPG----RVTI 295
T+ L+ Y V AS +AG +S+ ++ KT+ P V +
Sbjct: 1488 IQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHV 1547
Query: 296 QEDPPGHLSVAWS----------------SVDLGDYYVVFVKSDD--------GLEVHCN 331
P +S++WS SVD ++ + F+KS++ LE+
Sbjct: 1548 VATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTR 1607
Query: 332 TSLTQCNFLSECGFTYF---ISVFVYNKAGQSPLGDIFNYTTAPCCPSDIN-------PV 381
S+ F Y S + +S D N T P ++ P
Sbjct: 1608 YSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPP 1667
Query: 382 LVSSDRVEIVWSPVRGAELYETKAVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNE 441
+ +++ + V + + ++++ +T L L+ YNI+VY+ N
Sbjct: 1668 SQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNS 1727
Query: 442 V-RGSNMSCTPQFITTAPCSPEIK 464
G + AP P+ K
Sbjct: 1728 AGAGPKVPMRITMDIKAPARPKTK 1751
Score = 39.7 bits (91), Expect = 0.010
Identities = 123/627 (19%), Positives = 222/627 (35%), Gaps = 104/627 (16%)
Query: 22 VASAKSAPEIPTID-QAYSKLSNSITVEWATVPGATSYLLTAE----DGDTVIETTVANS 76
V +++ PE D + ++ I ++W+ ++ E + DT+ + +
Sbjct: 658 VRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTT 717
Query: 77 PGTVTGLKAATWYEITIRSISAAG-----------RSQASPPKQA------KTVLAAPI- 118
+ L+ T Y I++RS + G R+ + P A K + + I
Sbjct: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIE 777
Query: 119 LEVSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTI 178
L PSS + ++Q +Y+ R+NG +E T NT+ +++ YT
Sbjct: 778 LSFLPPSSPNGIIQKYTIYLK--------RSNGN----EERTINTTSLTQNIKVLKKYTQ 825
Query: 179 KAYAWNANRIPGDD------STCNQRTSPRAPANIQVSFDSGALKASFSWA---RAEGAF 229
+A+ + G+ S + +P +P + SW G
Sbjct: 826 YIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGII 885
Query: 230 -NYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKS-SSAMTLKTVA 287
YTV + SS T + T +S +S L EY V AS G K+ S+ ++ +T
Sbjct: 886 LYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPE 945
Query: 288 CAPGRVTIQEDPPG---HLSVAWSSVDLG-----------DYYVVFVKSDDGL------- 326
AP DPP + +++ SS+ L YY V+ ++ G
Sbjct: 946 GAP------SDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTL 999
Query: 327 --------EVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAP-CCPSD 377
+ +T + + S F S V N S + +++ P +
Sbjct: 1000 HEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGN 1059
Query: 378 INPVLVSSDRVEIVWSP---VRGAELYETKAVDGYNMVECNDTTPACT------LSALEC 428
+ +SS + + W P G Y + + P T LE
Sbjct: 1060 LTYESISSTAINVSWVPPAQPNGLVFYYVSLI--LQQTPRHVRPPLVTYERSIYFDNLEK 1117
Query: 429 DTKYNITVYSFNEVRGSNMSCTPQFITT----APCSPEIKNVSRDAFSMINVHW----RS 480
T Y + + E S+ +I T SP I + + + + W +
Sbjct: 1118 YTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKP 1177
Query: 481 TNDDATYTVTAQGEKGLYQCSSTGESCTMRGLPCGSVFSVTAVAETQAGRSLPS--YSVP 538
+Y +T QG Y ++ + L +++S A A T+ G S +
Sbjct: 1178 NGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYT 1237
Query: 539 LETVPCC-PTGLTVTQITQSVINVSWT 564
E+VP P LT+ T + + W+
Sbjct: 1238 DESVPLAPPQNLTLINCTSDFVWLKWS 1264
Score = 37.0 bits (84), Expect = 0.065
Identities = 81/355 (22%), Positives = 135/355 (38%), Gaps = 54/355 (15%)
Query: 250 SCTISSLQCGTEYLISVLASNDAGSSKSSSA-MTLKTVACAPGR--------------VT 294
S +L+ T+Y++ + S + G S + +A + +KT P V
Sbjct: 1109 SIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTSVL 1168
Query: 295 IQEDPPGHLSVAWSSVDLG----DYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFIS 350
+ DPP + A S DL + F+ SD+ + + + T +F +
Sbjct: 1169 LSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAAR------ 1222
Query: 351 VFVYNKAGQSPLGDIFNYT--TAPCCP-SDINPVLVSSDRVEIVWSP---------VRGA 398
+ G P +F YT + P P ++ + +SD V + WSP V
Sbjct: 1223 ----TRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSF 1278
Query: 399 ELYETKAVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNEV-RGSNMSCTPQFITTA 457
+++E + Y T A L LE + Y+I V +F +V G+ S +F T
Sbjct: 1279 KIHEHETDTIYYKNISGFKTEA-KLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQE 1337
Query: 458 PCSPEIKNVSRDAFSM--INVHW---RSTNDDAT-YTVTAQGEKGLYQCSSTGESCTMRG 511
++N+ A S + V W + N T Y VT E+ + S T
Sbjct: 1338 SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTV--ERNSTKVSPQDHMYTFIK 1395
Query: 512 LPCGSVFSVTAVAETQAGRSLPS---YSVPLETVPCCPTGLTVTQITQSVINVSW 563
L + + A T AG S S ETVP PT + + + + ++W
Sbjct: 1396 LLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTW 1450
Score = 34.7 bits (78), Expect = 0.32
Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 24/241 (9%)
Query: 347 YFISVFVYNKAGQSPLG---DIFNYTTAP---CCPSDINPVLVSSDRVEIVWSPVRGAE- 399
Y + V G+S L DIF T+ P D+ + V++D + + WSP
Sbjct: 635 YKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNG 694
Query: 400 ---LYETKAVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITT 456
YE + + N +T L L T YNI+V S+ N + + T
Sbjct: 695 IIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRT 754
Query: 457 APCSPE-------IKNVSRDAFSMINVHWRSTND-DATYTVTAQGEKGLYQ--CSSTGES 506
+ P+ KN+S + + S N YT+ + G + ++T +
Sbjct: 755 SETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLT 814
Query: 507 CTMRGLPCGSVFSVTAVAETQAG---RSLPSYSVPLETVP-CCPTGLTVTQITQSVINVS 562
++ L + + + A T G RS P + E P P +V Q++ + +S
Sbjct: 815 QNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLS 874
Query: 563 W 563
W
Sbjct: 875 W 875
Score = 33.9 bits (76), Expect = 0.55
Identities = 75/357 (21%), Positives = 124/357 (34%), Gaps = 62/357 (17%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVT-----------------I 295
+++L GT Y I V A N AG S +T APG+V +
Sbjct: 118 LTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYL 177
Query: 296 QEDPPGHLSVAWSSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYN 355
P G ++ SV +V +E L +CN SE F+++
Sbjct: 178 PRQPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSES--------FLWS 229
Query: 356 KAGQSP-LGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVEC 414
A SP LG + T P + + L ++ + VW + + Y
Sbjct: 230 TASPSPTLGRV----TPPSRTTHSSSTLTQNE-ISSVWKEPISFVVTHLRPYTTYLFEVS 284
Query: 415 NDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIK-NVSRDAFSM 473
TT A + S + TP+ + P + N++ +FS+
Sbjct: 285 AATTEAGYID--------------------STIVRTPESVPEGPPQNCVTGNITGKSFSI 324
Query: 474 INVHWRSTNDDATYTVTAQGEKGLYQCSSTGE-SCTMRGLPCGSVFSVTAVAETQAGRSL 532
+ +Y V G G +ST + L +++ V AET AG
Sbjct: 325 LWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTG- 383
Query: 533 PSYSVPLETVPCCPTG---LTVTQITQSVINVSW-----TIGRVAQTHVAVLESHTG 581
P ++ + T P P L + ++ + + ++W G + Q V VL TG
Sbjct: 384 PKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETG 440
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 53.9 bits (128), Expect = 5e-07
Identities = 141/709 (19%), Positives = 254/709 (35%), Gaps = 124/709 (17%)
Query: 7 TCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATVPG------ATSYLL 60
TC+ + +I + K+ P+ P + S+T+ W + Y
Sbjct: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
Query: 61 TAEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-- 118
+G VA + ++ GL + Y + ++++ GR S +A+T AP
Sbjct: 357 AGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP 416
Query: 119 ---LEVSSPSSDSILVQWEAVY--------MAIAFSVSIMRANGLGSIWKENTTNTSL-- 165
++ S+ ++LVQWE + ++ R + W ++ T+ L
Sbjct: 417 PRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRP---PNAWHKHNTDAGLLT 473
Query: 166 TFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTS---PRAPANIQVSFDSGA-LKASFS 221
T SL G Y+++ A+ A T +T P PA+ Q +S ++ S+
Sbjct: 474 TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWL 533
Query: 222 WARAEGAFNY-TVMALSDSSELTCSTTF---SSCTISSLQCGTEYLISVLASNDAG---- 273
E Y V ++ + TF SS T+ L+ T Y + A +D G
Sbjct: 534 LPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593
Query: 274 --------SSKSSSAMTLKTVACAPGRVTIQED---PPG--------HLSVAWSSVDLGD 314
+ + SA K + + G T++ PP SVA+ +VD D
Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653
Query: 315 --YYVVFVKSDDGL-EVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTA 371
+VV DG+ H + L +E Y + V + G P T
Sbjct: 654 RGRHVV-----DGISREHSSWDLVGLEKWTE----YRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 372 PCCPS------DINPVLVSSDRVEIVW---------SPVRGAELYETKAVDG-------- 408
PS ++ P ++S V + W +RG ++ + +G
Sbjct: 705 EDVPSGPPRKVEVEP--LNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPII 762
Query: 409 --YNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSP--EIK 464
+ E +T T+S L +T Y++TV ++ +G P+ +TT P
Sbjct: 763 QDVMLAEAQET----TISGLTPETTYSVTVAAYT-TKGDGARSKPKIVTTTGAVPGRPTM 817
Query: 465 NVSRDAFSMINVHWRSTND--------DATYTVTAQGEKGLYQCSSTGESCTMRGLPCGS 516
+S A + + W + Y + + T+ GL G+
Sbjct: 818 MISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGT 877
Query: 517 VFSVTAVAETQAGRSLPSYSVPLETVPCCPTG----LTVTQITQSVINVSWTIGRVAQTH 572
+ A+ +AG + + T P+G L VT +T S ++W +A+ +
Sbjct: 878 TYIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERN 936
Query: 573 VAVLESHTGQSKCHTHQNHCLLGCITCGINYTVTLKAISATGLTADCSY 621
++ ++ Q L IT +T+ TGL D +Y
Sbjct: 937 GRIISYTVVFRDINSQQE---LQNITTDTRFTL-------TGLKPDTTY 975
Score = 46.6 bits (109), Expect = 8e-05
Identities = 56/231 (24%), Positives = 94/231 (40%), Gaps = 28/231 (12%)
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKT---VLAAPILEVSSPSSDSILVQW-- 133
T++GL T Y +T+ + + G S PK T V P + +S+ + ++ L+QW
Sbjct: 774 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHP 833
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENT-----TNTSLTFTSLEAGTLYTIKAYAWNAN 186
E + + + RA+ + NT + T T L GT Y + A N
Sbjct: 834 PKELPGELLGYRLQYCRADEA----RPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRA 889
Query: 187 RIPGDDSTCNQRTSPRAPANIQVSFDSGALKAS---FSW------ARAEGAFNYTVM--A 235
+ G++ RT P+ + L S +W R +YTV+
Sbjct: 890 GL-GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 948
Query: 236 LSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTV 286
++ EL TT + T++ L+ T Y I V A GS S ++ +T+
Sbjct: 949 INSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 999
Score = 37.4 bits (85), Expect = 0.050
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTV----LAAPILEVSSPSSDSILVQWE 134
T+TGLK T Y+I +R+ ++ G SP Q++T+ + A V++ S+L+ WE
Sbjct: 965 TLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWE 1024
Query: 135 -------AVYMAIAFSVSIMRANG--LGSIWKENTTNTSLTFTSLEAGT 174
AV I ++ + +G + + + NT +F + G+
Sbjct: 1025 VPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGS 1073
Score = 36.2 bits (82), Expect = 0.11
Identities = 46/201 (22%), Positives = 81/201 (40%), Gaps = 22/201 (10%)
Query: 20 KMVASAKSAPEIPTIDQAYSKLSNSITVEW---ATVPGAT-----SYLLTAEDGDTVIET 71
K+V + + P PT+ + + + N+ ++W +PG Y E I+
Sbjct: 803 KIVTTTGAVPGRPTMMISTTAM-NTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDF 861
Query: 72 TVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-----LEVSSPSS 126
+ TVTGL T Y + + + AG + K+ +T P L V+ ++
Sbjct: 862 GKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE-KEIRTPEDLPSGFPQNLHVTGLTT 920
Query: 127 DSILVQWEAVYMA------IAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKA 180
+ + W+ +A I+++V N + + TT+T T T L+ T Y IK
Sbjct: 921 STTELAWDPPVLAERNGRIISYTVVFRDINSQQEL-QNITTDTRFTLTGLKPDTTYDIKV 979
Query: 181 YAWNANRIPGDDSTCNQRTSP 201
AW + + RT P
Sbjct: 980 RAWTSKGSGPLSPSIQSRTMP 1000
Score = 31.2 bits (69), Expect = 3.6
Identities = 55/243 (22%), Positives = 90/243 (37%), Gaps = 49/243 (20%)
Query: 252 TISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVT------------IQEDP 299
TIS L T Y ++V A G S + T PGR T +Q P
Sbjct: 774 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHP 833
Query: 300 PGHLSVAWSSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFL---SECGFTYFISVFVYNK 356
P L +L Y + + ++D+ + +F G TY + N+
Sbjct: 834 PKEL-----PGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 888
Query: 357 AGQSPLGDIF--NYTTAPCCPS----DINPVLVSSDRVEIVWSPVRGAE--------LYE 402
AG LG+ F T PS +++ +++ E+ W P AE
Sbjct: 889 AG---LGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVV 945
Query: 403 TKAVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPE 462
+ ++ ++ T TL+ L+ DT Y+I V ++ +GS P SP
Sbjct: 946 FRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTS-KGS-----------GPLSPS 993
Query: 463 IKN 465
I++
Sbjct: 994 IQS 996
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 53.5 bits (127), Expect = 7e-07
Identities = 63/309 (20%), Positives = 123/309 (39%), Gaps = 25/309 (8%)
Query: 7 TCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATV-PGATSYLLT---- 61
TC+ + +I + KS P+ P + SIT+ W + P SY +
Sbjct: 297 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356
Query: 62 -AEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-- 118
++DG I+ + + ++ GL + YEI + ++++ G+ S +T AP
Sbjct: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
Query: 119 ---LEVSSPSSDSILVQWE------AVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFT- 168
++ S+ +++VQWE + ++ + +G+ K N ++ LT
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
Query: 169 SLEAGTLYTIKAYAWNA---NRIPGDDSTCNQRTSPRAPANIQVSFDS-GALKASFSWAR 224
SL YT++ A+ + + Q+ P P N++ S ++ S+S R
Sbjct: 477 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 536
Query: 225 AEGAFNYTVMALSDSSELTCSTTF---SSCTISSLQCGTEYLISVLASNDAGSSKSSSAM 281
E Y ++ TF +S + L+ TEY + A + G + +
Sbjct: 537 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 596
Query: 282 TLKTVACAP 290
+T+ P
Sbjct: 597 RQRTLQSKP 605
Score = 41.6 bits (96), Expect = 0.003
Identities = 67/269 (24%), Positives = 104/269 (38%), Gaps = 52/269 (19%)
Query: 252 TISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGR---VTIQEDPPGHLSVAWS 308
T+ SL Y + VLA G S + +KT PG+ + + ++++WS
Sbjct: 474 TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 533
Query: 309 ---SVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLG-- 363
+ Y ++F + D G EV T + + + + + A +SP G
Sbjct: 534 PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPN---TEYAFRLAARSPQGLG 590
Query: 364 ---------DIFNYTTAPCCPSDINPVLVSSDRVEIVWSP--------------VR---- 396
+ + +AP P D+ V V S + + W P VR
Sbjct: 591 AFTPVVRQRTLQSKPSAP--PQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 648
Query: 397 GAELYETKAVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITT 456
G+E E K V+G TT L ALE T+Y IT + EV G +P + T
Sbjct: 649 GSEDPEPKEVNG-----IPPTTTQILLEALEKWTQYRITTVAHTEV-GPGPESSPVVVRT 702
Query: 457 ---APCSPEIKNVSRDAF--SMINVHWRS 480
P +P + V +A + I V WRS
Sbjct: 703 DEDVPSAPP-RKVEAEALNATAIRVLWRS 730
Score = 37.4 bits (85), Expect = 0.050
Identities = 54/232 (23%), Positives = 93/232 (40%), Gaps = 24/232 (10%)
Query: 267 LASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--KS 322
+A + G ++ + +T+K++ APG + E+ +++ W S D YYV+ KS
Sbjct: 299 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKS 358
Query: 323 DDG---LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTT---APC-CP 375
DG ++ T+ LS Y I V N GQ P + T AP P
Sbjct: 359 QDGPYQIKEDITTTRYSIGGLSP-NSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417
Query: 376 SDINPVLVSSDRVEIVWSP-------VRGAELYET----KAVDGYNMVECNDTTPACTLS 424
++ ++S+ + + W +RG +Y T V + +D+ S
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477
Query: 425 ALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINV 476
LE D Y + V +F V +S Q T + N+ +A S ++
Sbjct: 478 LLE-DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 528
Score = 35.0 bits (79), Expect = 0.25
Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 3/58 (5%)
Query: 80 VTGLKAATWYEITIRSISAAGRSQASPPKQAKT---VLAAPILEVSSPSSDSILVQWE 134
+T L+ T Y IT+ + + G S PK T VL P L V S+L +WE
Sbjct: 774 ITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWE 831
Score = 32.7 bits (73), Expect = 1.2
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 9/74 (12%)
Query: 70 ETTVANSPG-----TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI----LE 120
E A PG T+ GLK T Y++ +R+ + G SPP + +T L + +
Sbjct: 960 ELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFK 1019
Query: 121 VSSPSSDSILVQWE 134
V S+L+ WE
Sbjct: 1020 VKMIMKTSVLLSWE 1033
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 53.5 bits (127), Expect = 7e-07
Identities = 63/309 (20%), Positives = 123/309 (39%), Gaps = 25/309 (8%)
Query: 7 TCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATV-PGATSYLLT---- 61
TC+ + +I + KS P+ P + SIT+ W + P SY +
Sbjct: 310 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 369
Query: 62 -AEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-- 118
++DG I+ + + ++ GL + YEI + ++++ G+ S +T AP
Sbjct: 370 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 429
Query: 119 ---LEVSSPSSDSILVQWE------AVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFT- 168
++ S+ +++VQWE + ++ + +G+ K N ++ LT
Sbjct: 430 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 489
Query: 169 SLEAGTLYTIKAYAWNA---NRIPGDDSTCNQRTSPRAPANIQVSFDS-GALKASFSWAR 224
SL YT++ A+ + + Q+ P P N++ S ++ S+S R
Sbjct: 490 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 549
Query: 225 AEGAFNYTVMALSDSSELTCSTTF---SSCTISSLQCGTEYLISVLASNDAGSSKSSSAM 281
E Y ++ TF +S + L+ TEY + A + G + +
Sbjct: 550 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 609
Query: 282 TLKTVACAP 290
+T+ P
Sbjct: 610 RQRTLQSKP 618
Score = 42.4 bits (98), Expect = 0.002
Identities = 79/338 (23%), Positives = 115/338 (34%), Gaps = 55/338 (16%)
Query: 22 VASAKSAPEIPTIDQAYSKLSNSITVEWATV--PGATSYLLTAEDGDTVIETTVANSPGT 79
V + + P P +A ++ SIT+ W+ Y L +GD E P T
Sbjct: 518 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 577
Query: 80 ---VTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-----LEVSSPSSDSILV 131
V LK T Y + + S G +P + +T+ + P ++ S S +ILV
Sbjct: 578 SYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILV 637
Query: 132 QWEAVY------MAIAFSVSIMRANGLGSIWKENT-------TNTSLTFTSLEAGTLYTI 178
W + +SV R LGS E T T + +LE T Y I
Sbjct: 638 SWRPPPPETHNGALVGYSV---RYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRI 694
Query: 179 KAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKAS------------------- 219
A + S RT P+ ++ AL A+
Sbjct: 695 TTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIR 754
Query: 220 --------FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASND 271
A A G + L+D+ T T I++LQ T Y I+V A
Sbjct: 755 GYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTAEYEMVITNLQPETAYSITVAAYTM 814
Query: 272 AGSSKSSSAMTLKTVACAPGRVT--IQEDPPGHLSVAW 307
G S + T GR T +Q+ P G L W
Sbjct: 815 KGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARW 852
Score = 41.6 bits (96), Expect = 0.003
Identities = 67/269 (24%), Positives = 104/269 (38%), Gaps = 52/269 (19%)
Query: 252 TISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGR---VTIQEDPPGHLSVAWS 308
T+ SL Y + VLA G S + +KT PG+ + + ++++WS
Sbjct: 487 TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS 546
Query: 309 ---SVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLG-- 363
+ Y ++F + D G EV T + + + + + A +SP G
Sbjct: 547 PPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPN---TEYAFRLAARSPQGLG 603
Query: 364 ---------DIFNYTTAPCCPSDINPVLVSSDRVEIVWSP--------------VR---- 396
+ + +AP P D+ V V S + + W P VR
Sbjct: 604 AFTPVVRQRTLQSKPSAP--PQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 661
Query: 397 GAELYETKAVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITT 456
G+E E K V+G TT L ALE T+Y IT + EV G +P + T
Sbjct: 662 GSEDPEPKEVNG-----IPPTTTQILLEALEKWTQYRITTVAHTEV-GPGPESSPVVVRT 715
Query: 457 ---APCSPEIKNVSRDAF--SMINVHWRS 480
P +P + V +A + I V WRS
Sbjct: 716 DEDVPSAPP-RKVEAEALNATAIRVLWRS 743
Score = 37.4 bits (85), Expect = 0.050
Identities = 54/232 (23%), Positives = 93/232 (40%), Gaps = 24/232 (10%)
Query: 267 LASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--KS 322
+A + G ++ + +T+K++ APG + E+ +++ W S D YYV+ KS
Sbjct: 312 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKS 371
Query: 323 DDG---LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTT---APC-CP 375
DG ++ T+ LS Y I V N GQ P + T AP P
Sbjct: 372 QDGPYQIKEDITTTRYSIGGLSP-NSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 430
Query: 376 SDINPVLVSSDRVEIVWSP-------VRGAELYET----KAVDGYNMVECNDTTPACTLS 424
++ ++S+ + + W +RG +Y T V + +D+ S
Sbjct: 431 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 490
Query: 425 ALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINV 476
LE D Y + V +F V +S Q T + N+ +A S ++
Sbjct: 491 LLE-DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 541
Score = 35.0 bits (79), Expect = 0.25
Identities = 20/58 (34%), Positives = 27/58 (46%), Gaps = 3/58 (5%)
Query: 80 VTGLKAATWYEITIRSISAAGRSQASPPKQAKT---VLAAPILEVSSPSSDSILVQWE 134
+T L+ T Y IT+ + + G S PK T VL P L V S+L +WE
Sbjct: 796 ITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWE 853
Score = 32.7 bits (73), Expect = 1.2
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 9/74 (12%)
Query: 70 ETTVANSPG-----TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI----LE 120
E A PG T+ GLK T Y++ +R+ + G SPP + +T L + +
Sbjct: 982 ELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFK 1041
Query: 121 VSSPSSDSILVQWE 134
V S+L+ WE
Sbjct: 1042 VKMIMKTSVLLSWE 1055
>gi|241896926 protein tyrosine phosphatase, receptor type, H isoform
2 precursor [Homo sapiens]
Length = 937
Score = 52.8 bits (125), Expect = 1e-06
Identities = 75/357 (21%), Positives = 136/357 (38%), Gaps = 38/357 (10%)
Query: 153 GSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFD 212
G+ NTT T++T L G+LYT + + + T T+P N+ V
Sbjct: 72 GTTETRNTTATNVTVDGLGPGSLYTCSVWV-EKDGVNSSVGTVTTATAPNPVRNLTVEAQ 130
Query: 213 SGALKASFSWARAEGA----FNYTVMALSDSSEL-TCSTTFSSCTISSLQCGTEYLISVL 267
+ + + +W +G Y V D T ST ++ T+ L+ G Y+ SV
Sbjct: 131 TNS-SIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVW 189
Query: 268 ASNDAGSSKSSSAMTLKTVACAPGRVT---IQEDPPGHLSVAWSSVDLG-----DYYVVF 319
G + +S+ + AP V ++ +++ W D Y+V +
Sbjct: 190 ----VGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEY 245
Query: 320 VKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDIN 379
G E T+ + E G Y SV+ + ++ + +T P + ++
Sbjct: 246 TGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNV-SISTVPNAVTSLS 304
Query: 380 PVLVSSDRVEIVWSPVRGA-----ELYETKAVDGYNMVECNDTTPA-CTLSALECDTKYN 433
++ + + W+ +G + + +G T+ TL LE + Y+
Sbjct: 305 KQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSLYH 364
Query: 434 ITVYS-FNEVRGSNMSCT----PQFITTAPCSPEIKN-------VSRDAFSMINVHW 478
+TV++ NEVRG N + T P +T + KN D S + V+W
Sbjct: 365 LTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYW 421
Score = 49.3 bits (116), Expect = 1e-05
Identities = 62/273 (22%), Positives = 112/273 (41%), Gaps = 27/273 (9%)
Query: 39 SKLSNSITVEWATVPG-----ATSYLLTAEDGDTVIETTVANSPGTVTGLKAATWYEITI 93
++ ++SI + W G +T + DG + A++ TV L+ Y ++
Sbjct: 129 AQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSV 188
Query: 94 RSISAAGRSQASPPKQAKTVLAAPI----LEVSSPSSDSILVQWEAVYMAIA--FSVSIM 147
G++ + ++ + AP L + + ++ SI + WE ++ +
Sbjct: 189 W----VGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVE 244
Query: 148 RANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANI 207
G NTTNTS+T LE GTLYT +A N G + T P A ++
Sbjct: 245 YTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWA-EKNGARGSRQNVSISTVPNAVTSL 303
Query: 208 QVSFDSGALKASFSWARAEG----AFNYTVMALSD--SSELTCSTTFSSCTISSLQCGTE 261
D + W +G +++Y V + + + T ST+ + T+ L+ G+
Sbjct: 304 SKQ-DWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL 362
Query: 262 YLISVLASNDAGSSKSSSAMTLKTVACAPGRVT 294
Y ++V A + +S+ T A AP VT
Sbjct: 363 YHLTVWAERNEVRGYNSTL----TAATAPNEVT 391
Score = 43.9 bits (102), Expect = 5e-04
Identities = 69/291 (23%), Positives = 109/291 (37%), Gaps = 20/291 (6%)
Query: 290 PGR-VTIQEDPPGHLSVAWSSVDLGDY----YVVFVKSDDGLEVHCNTSLTQCNFLS-EC 343
PGR +T++ +S++W D D Y V D G NT+ T
Sbjct: 32 PGRNLTVETQTTSSISLSWEVPDGLDSQNSNYWVQCTGDGGTTETRNTTATNVTVDGLGP 91
Query: 344 GFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRGAELYET 403
G Y SV+V S +G + TAP ++ ++ + + W G + +
Sbjct: 92 GSLYTCSVWVEKDGVNSSVGTVTT-ATAPNPVRNLTVEAQTNSSIALTWEVPDGPDPQNS 150
Query: 404 K-----AVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAP 458
DG + T+ LE Y +V+ G N S + TTAP
Sbjct: 151 TYGVEYTGDGGRAGTRSTAHTNITVDRLEPGCLYVFSVWVGKN--GINSSRETRNATTAP 208
Query: 459 CSPEIKNVSRDAFSMINVHWRSTN----DDATYTVTAQGEKGLYQC-SSTGESCTMRGLP 513
++ S I + W + D TY V G+ G + ++T S T L
Sbjct: 209 NPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYWVEYTGDGGGTETRNTTNTSVTAERLE 268
Query: 514 CGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWT 564
G++++ + AE R +V + TVP T L+ T S I + WT
Sbjct: 269 PGTLYTFSVWAEKNGARG-SRQNVSISTVPNAVTSLSKQDWTNSTIALRWT 318
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 52.0 bits (123), Expect = 2e-06
Identities = 62/305 (20%), Positives = 122/305 (40%), Gaps = 25/305 (8%)
Query: 7 TCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATV-PGATSYLLT---- 61
TC+ + +I + KS P+ P + SIT+ W + P SY +
Sbjct: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360
Query: 62 -AEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-- 118
++DG I+ + + ++ GL + YEI + ++++ G+ S +T AP
Sbjct: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420
Query: 119 ---LEVSSPSSDSILVQWE------AVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFT- 168
++ S+ +++VQWE + ++ + +G+ K N ++ LT
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480
Query: 169 SLEAGTLYTIKAYAWNA---NRIPGDDSTCNQRTSPRAPANIQVSFDS-GALKASFSWAR 224
SL YT++ A+ + + Q+ P P N++ S ++ S+S R
Sbjct: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540
Query: 225 AEGAFNYTVMALSDSSELTCSTTF---SSCTISSLQCGTEYLISVLASNDAGSSKSSSAM 281
E Y ++ TF +S + L+ TEY + A + G + +
Sbjct: 541 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 600
Query: 282 TLKTV 286
+T+
Sbjct: 601 RQRTL 605
Score = 37.4 bits (85), Expect = 0.050
Identities = 54/232 (23%), Positives = 93/232 (40%), Gaps = 24/232 (10%)
Query: 267 LASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--KS 322
+A + G ++ + +T+K++ APG + E+ +++ W S D YYV+ KS
Sbjct: 303 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKS 362
Query: 323 DDG---LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTT---APC-CP 375
DG ++ T+ LS Y I V N GQ P + T AP P
Sbjct: 363 QDGPYQIKEDITTTRYSIGGLSP-NSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 421
Query: 376 SDINPVLVSSDRVEIVWSP-------VRGAELYET----KAVDGYNMVECNDTTPACTLS 424
++ ++S+ + + W +RG +Y T V + +D+ S
Sbjct: 422 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 481
Query: 425 ALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINV 476
LE D Y + V +F V +S Q T + N+ +A S ++
Sbjct: 482 LLE-DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 532
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 52.0 bits (123), Expect = 2e-06
Identities = 62/305 (20%), Positives = 122/305 (40%), Gaps = 25/305 (8%)
Query: 7 TCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATV-PGATSYLLT---- 61
TC+ + +I + KS P+ P + SIT+ W + P SY +
Sbjct: 297 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356
Query: 62 -AEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-- 118
++DG I+ + + ++ GL + YEI + ++++ G+ S +T AP
Sbjct: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
Query: 119 ---LEVSSPSSDSILVQWE------AVYMAIAFSVSIMRANGLGSIWKENTTNTSLTFT- 168
++ S+ +++VQWE + ++ + +G+ K N ++ LT
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
Query: 169 SLEAGTLYTIKAYAWNA---NRIPGDDSTCNQRTSPRAPANIQVSFDS-GALKASFSWAR 224
SL YT++ A+ + + Q+ P P N++ S ++ S+S R
Sbjct: 477 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 536
Query: 225 AEGAFNYTVMALSDSSELTCSTTF---SSCTISSLQCGTEYLISVLASNDAGSSKSSSAM 281
E Y ++ TF +S + L+ TEY + A + G + +
Sbjct: 537 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 596
Query: 282 TLKTV 286
+T+
Sbjct: 597 RQRTL 601
Score = 37.4 bits (85), Expect = 0.050
Identities = 54/232 (23%), Positives = 93/232 (40%), Gaps = 24/232 (10%)
Query: 267 LASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--KS 322
+A + G ++ + +T+K++ APG + E+ +++ W S D YYV+ KS
Sbjct: 299 VAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKS 358
Query: 323 DDG---LEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTT---APC-CP 375
DG ++ T+ LS Y I V N GQ P + T AP P
Sbjct: 359 QDGPYQIKEDITTTRYSIGGLSP-NSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417
Query: 376 SDINPVLVSSDRVEIVWSP-------VRGAELYET----KAVDGYNMVECNDTTPACTLS 424
++ ++S+ + + W +RG +Y T V + +D+ S
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477
Query: 425 ALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPEIKNVSRDAFSMINV 476
LE D Y + V +F V +S Q T + N+ +A S ++
Sbjct: 478 LLE-DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSI 528
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform
1 precursor [Homo sapiens]
Length = 1337
Score = 50.4 bits (119), Expect = 6e-06
Identities = 98/460 (21%), Positives = 167/460 (36%), Gaps = 47/460 (10%)
Query: 168 TSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKASFSWARAEG 227
T L T Y N GD T P ++++V+ +G KA+ SW+ G
Sbjct: 174 TGLRPATSYVFSITPGIGNETWGDPRVIKVITEPIPVSDLRVAL-TGVRKAALSWSNGNG 232
Query: 228 AFNYTVM--ALSDSSELTCSTTFSSCTISSLQCGTEYLIS--VLASNDAGSSKSSS---- 279
+ V+ ++ ELT + IS L+ G +Y I+ +L SN +
Sbjct: 233 TASCRVLLESIGSHEELTQDSRLQ-VNISGLKPGVQYNINPYLLQSNKTKGDPLGTEGGL 291
Query: 280 --AMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYYVVFVKSDDGLEVHCNTSLTQC 337
+ T ++ A +P E G + + S D V+ V GLE
Sbjct: 292 DASNTERSRAGSPTAPVHDESLVGPVDPS-SGQQSRDTEVLLV----GLEP--------- 337
Query: 338 NFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCCPSDINPVLVSSDRVEIVWSPVRG 397
G Y +V+ G + T D+ V +S+ + ++W
Sbjct: 338 ------GTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISATSLTLIWKVSDN 391
Query: 398 AE----LYETKAVDGYNMVECNDTTPACTLSALECDTKYNITVYS-FNEVRGSNMSCTPQ 452
Y+ + N + P + L T YNITV ++ G TP
Sbjct: 392 ESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEG-----TPG 446
Query: 453 FIT--TAPCSPEIKNVSRDAFSMINVHWRSTNDDATYT-VTAQGEKGLYQCSSTGESCTM 509
F+ T P V+ + + I + W S + ++ +T +G +T +S +
Sbjct: 447 FLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITTNQSIII 506
Query: 510 RGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTGLTVTQITQSVINVSWTIGRVA 569
GL G+ + V + G S +V TVP + V +T + + + W A
Sbjct: 507 GGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGA 566
Query: 570 QTHV--AVLESHTGQSKCHTHQNHCLLGCITCGINYTVTL 607
+V V+ES G + T+ L + G Y +T+
Sbjct: 567 SEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITI 606
Score = 47.0 bits (110), Expect = 6e-05
Identities = 57/233 (24%), Positives = 98/233 (42%), Gaps = 13/233 (5%)
Query: 42 SNSITVEWATVPGATSYLLTAE---DGDTVIETTVANSP-GTVTGLKAATWYEITIRSIS 97
+ S+T+ W +S T + G+T + P + GL+++T+Y IT+ +
Sbjct: 379 ATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNLNVSEPRAVIPGLRSSTFYNITVCPV- 437
Query: 98 AAGRSQASPPKQAKTVLAAPILE--VSSPSSDSILVQWEAVYMAIAFSVSIMRANGLGSI 155
G + +P P+ + V+ S+ I + W + + A +F + I + G G+
Sbjct: 438 -LGDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSS-HDAESFQMHITQ-EGAGNS 494
Query: 156 WKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGA 215
E TTN S+ L GT Y + N G T RT P A +I V + +
Sbjct: 495 RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVT-T 553
Query: 216 LKASFSWARAEGAFNYTVMALSDSSELT--CSTTFSSCTISSLQCGTEYLISV 266
+ W +GA Y + +S + ST + T+ L GT Y I++
Sbjct: 554 TEMWLDWKSPDGASEYVYHLVIESKHGSNHTSTYDKAITLQGLIPGTLYNITI 606
Score = 42.0 bits (97), Expect = 0.002
Identities = 61/283 (21%), Positives = 120/283 (42%), Gaps = 28/283 (9%)
Query: 29 PEIPTIDQAYSKLSNS-ITVEWATVPGATSYLLTAEDG--DTVIETTVANSPGTVTGLKA 85
P +P D + +S + I + W++ + + ++G ++ +E T N + GL
Sbjct: 453 PPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHITQEGAGNSRVEITT-NQSIIIGGLFP 511
Query: 86 ATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-LEVSSPSSDSILVQWEAVYMAIAFSV 144
T Y I G AS +TV +A + V ++ + + W++ A +
Sbjct: 512 GTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYVTTTEMWLDWKSPDGASEYVY 571
Query: 145 SIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTSPRAP 204
++ + GS +T + ++T L GTLY I + + + GD ++ Q T P
Sbjct: 572 HLVIESKHGSN-HTSTYDKAITLQGLIPGTLYNI-TISPEVDHVWGDPNSTAQYTRPSNV 629
Query: 205 ANIQVSFDSGALKASFSWARAEGA---FNYTVMA-----LSDSSELTCSTTFSSCTISSL 256
+NI VS ++ A A+ SW + A ++Y ++ S+++++ + T++ L
Sbjct: 630 SNIDVSTNTTA--ATLSWQNFDDASPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTEL 687
Query: 257 QCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDP 299
G+ Y + + A G + PGR + DP
Sbjct: 688 IPGSSYTVEIFAQVGDGIK-----------SLEPGRKSFCTDP 719
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 50.1 bits (118), Expect = 7e-06
Identities = 100/423 (23%), Positives = 152/423 (35%), Gaps = 64/423 (15%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEW--------ATVPG-ATSYLLTAEDGDTVIETTVANSP 77
S P+ P + NS T+ W A + G TSY + D E +V
Sbjct: 18797 SEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDL 18856
Query: 78 G-TVTGLKAATWYEITIRSISAAGRS---QASPPKQAKTVLAAPILEVSSPSSDSILVQW 133
VTGLK Y+ + + +A G S +A +AK L P ++ P +I
Sbjct: 18857 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPP--KILMPEQITIKAGK 18914
Query: 134 EAVYMAIAFSVSIMRANGLGSIWK----ENTTNTSLTFTSLEAGTLYTIKA--------Y 181
+ A + WK E T++ L ++ ++ IK Y
Sbjct: 18915 KLRIEAHVYGKPHPTCK-----WKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYY 18969
Query: 182 AWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKA---SFSWA-----RAEGAFNYTV 233
+ A G D+ + AP Q FD + A S SW NY V
Sbjct: 18970 SLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIV 19029
Query: 234 ----MALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKT---- 285
++ D S T +SC + L G EY+ V A N G S+ ++ +
Sbjct: 19030 EKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPF 19089
Query: 286 -VACAPGRVTIQEDPPGHLSVAWSSVD------LGDYYVVFVKSDDGLEVHCNTSLTQ-- 336
V P + + + VAW D + Y + + + L V N +L +
Sbjct: 19090 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRST 19149
Query: 337 ---CNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTA--PCCPSDINPVL-VSSDRVEI 390
C L E G Y ++ NKAG SP Y TA P P V+ V+ V +
Sbjct: 19150 EYPCAGLVE-GLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSL 19208
Query: 391 VWS 393
+W+
Sbjct: 19209 IWA 19211
Score = 47.8 bits (112), Expect = 4e-05
Identities = 84/426 (19%), Positives = 164/426 (38%), Gaps = 69/426 (16%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEWATVPG-----ATSYLLTAEDGDT------VIETTVAN 75
+ P+ P I + + NSIT+ WA Y+L + + + + ++
Sbjct: 28150 TVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISE 28209
Query: 76 SPGTVTGLKAATWYEITIRSISAAGRSQASPPKQ---AKTVLAAP----ILEVSSPSSDS 128
+ VTGL YE + + +AAG AS + + + P +++V+ S +
Sbjct: 28210 TRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTT 28269
Query: 129 ILVQWEAVYM-----AIAFSVSIMRANGLGSIWKENT---TNTSLTFTSLEAGTLYTIKA 180
+ ++W I + + + +A+ LG K N T T T L+AG Y +
Sbjct: 28270 VSLEWSKPVFDGGMEIIGYIIEMCKAD-LGDWHKVNAEACVKTRYTVTDLQAGEEYKFRV 28328
Query: 181 YAWNAN------RIPGDDSTCNQRTSP--------------RAPANIQVSFD-SGALKAS 219
A N + G ++ T+P RA A+I++ G +
Sbjct: 28329 SAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPT 28388
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W++ + LS +++ + +FS+ T+ + ++ N++GS +
Sbjct: 28389 AVWSKPDSN-------LSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITF 28441
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLG---DYYVV-----FVKSDDGLEVH 329
+ + PG +T ++ G ++ W + +D G +YVV +S +
Sbjct: 28442 TVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEK 28501
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAGQS---PLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + N L+E G Y+ V N+ G + + T P P ++ V S
Sbjct: 28502 CTRQIFKVNDLAE-GVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKS 28560
Query: 387 RVEIVW 392
+ W
Sbjct: 28561 SAVLAW 28566
Score = 46.2 bits (108), Expect = 1e-04
Identities = 93/435 (21%), Positives = 153/435 (35%), Gaps = 74/435 (17%)
Query: 24 SAKSAPEIPTIDQAYSKLSNSITVEWATVP-----GATSYLLTAEDGDTVIETTVANSP- 77
S AP+ PT+ S NS+TV W T Y L +D + V P
Sbjct: 16315 SVPGAPDKPTVS---SVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPI 16371
Query: 78 --------GTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVL------AAPILEVSS 123
VTGL + Y+ + +I+AAG AS P T P +V+
Sbjct: 16372 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTD 16431
Query: 124 PSSDSILVQWEAVYMAIAFSVS--IMRANGLG-SIWK----ENTTNTSLTFTSLEAGTLY 176
+ S ++W V+ I+ G W+ + T L T L+ G Y
Sbjct: 16432 WTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFY 16491
Query: 177 TIKAYAWNANRI--PGD------------------DSTCNQRTSPRAPANIQ-VSFDSGA 215
+ A N I PG+ D++ R A I+ +++ SG
Sbjct: 16492 KFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 16551
Query: 216 LKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSS 275
+ +W N L + + + SS I + Q + + S+LA N+AG
Sbjct: 16552 PPPTVTW-------NMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGER 16604
Query: 276 KSSSAMTLKTVACAPGRVTIQEDPPGH-LSVAWSSVD------LGDYYVVFVKSDDGLEV 328
K + + + V G + + + W S + + +Y + +SD
Sbjct: 16605 KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWT 16664
Query: 329 HCNTSLTQCNFLSE---CGFTYFISVFVYNKAGQSPLGD------IFNYTTAPCCPSDIN 379
++T+ N + G YF + N G P + I T P P D+
Sbjct: 16665 PVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLE 16724
Query: 380 PVLVSSDRVEIVWSP 394
V+ + V + W+P
Sbjct: 16725 VKEVTKNTVTLTWNP 16739
Score = 41.2 bits (95), Expect = 0.003
Identities = 102/484 (21%), Positives = 185/484 (38%), Gaps = 83/484 (17%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV--PGATS---YLLTAEDGDTVIET-----TVANSPG 78
P P+ + + +S+ V WA G T Y+L D + V T T+ +
Sbjct: 24902 PGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRL 24961
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAP----ILEVSSPSSDSILV 131
VTGL YE + + +AAG + S P +A L P +V+ S S+ +
Sbjct: 24962 RVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSL 25021
Query: 132 QW-EAVYMAIA----FSVSIMRANGLGSIWKENTTNTSL-----TFTSLEAGTLYTIKAY 181
W + +Y A + V + A W T T L T T L+ T Y +
Sbjct: 25022 AWSKPIYDGGAPVKGYVVEVKEA--AADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRIC 25079
Query: 182 AWNANRIPGDDST------CNQRTSP---------------RAPANIQVSFD-SGALKAS 219
A N+ + G+ +T +R P RA A +++ G +
Sbjct: 25080 AINSEGV-GEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPE 25138
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W +AEG L+D +++ +++F+ I ++ ++ N++GS +
Sbjct: 25139 VKWEKAEG-------ILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFV 25191
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--------KSDDGLEVH 329
+ + AP +TI+E ++++W +D G ++ K+ + +
Sbjct: 25192 NVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNN 25251
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAG---QSPLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + L E G +Y+ V N+ G + + + P P + V V+ +
Sbjct: 25252 CTKTTFRIENLQE-GCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 25310
Query: 387 RVEIVW--------SPVRGAEL-YETKAVDGYNMVECNDTTPACTLSALECDTKYNITVY 437
I W S + G + +TK + ++ T A T+S L +Y V
Sbjct: 25311 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA-TISGLTAGEEYVFRVA 25369
Query: 438 SFNE 441
+ NE
Sbjct: 25370 AVNE 25373
Score = 40.8 bits (94), Expect = 0.005
Identities = 129/605 (21%), Positives = 217/605 (35%), Gaps = 114/605 (18%)
Query: 56 TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAK 111
++Y++ D T ++ TVA + +T LK T Y+ I + + G+S +P
Sbjct: 24438 SNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKS--APLDSKA 24495
Query: 112 TVLAAPILE--------VSSPSSDSILVQW-----EAVYMAIAFSVSIMRANGLGSIW-K 157
++ P E V+S S D +LVQW + I + + N + +W K
Sbjct: 24496 VIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSI--LWVK 24553
Query: 158 ENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFD 212
N T +T T L+ G Y K A N I P S C P P +
Sbjct: 24554 LNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIV 24613
Query: 213 SGALKASFSWARA--EGAFNYT-----VMALSDSSELTCSTT---FSSCTISSLQCGTEY 262
+ W + +G T L D + S T + T+S L Y
Sbjct: 24614 ITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRY 24673
Query: 263 LISVLASNDAGS----SKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYYVV 318
V+A N AG+ S SS A+T + AP P + V V G+ +V+
Sbjct: 24674 EFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASL----DPKYKDVI--VVHAGETFVL 24727
Query: 319 -----------FVKSDDGLEVH------------CNTSLTQCNFLSECGFTYFISVFVYN 355
V S DG E+ T+L + + G Y + + N
Sbjct: 24728 EADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILK--LSN 24785
Query: 356 KAGQSPLGDIFNYTTAPCCP-SDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVEC 414
G + P P + V++++ + W+P L + A + ++E
Sbjct: 24786 VGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNP----PLQDGGANISHYIIEK 24841
Query: 415 NDT-----TPACT--------LSALECDTKYNITVYSFNEV-------RGSNMSCTPQFI 454
+T T T ++ L +Y V + N+ G +C P
Sbjct: 24842 RETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKP 24901
Query: 455 TTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT----YTVTAQGEKGLYQCSSTGESCT-- 508
P +PE+ +++D SM+ R +D T Y + + ++G+ ++ T
Sbjct: 24902 PGPPSTPEVSAITKD--SMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDL 24959
Query: 509 ---MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETV------PCCPTGLTVTQITQSVI 559
+ GL G + AE AG PS P P+ VT ++S +
Sbjct: 24960 RLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSV 25019
Query: 560 NVSWT 564
+++W+
Sbjct: 25020 SLAWS 25024
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/242 (23%), Positives = 94/242 (38%), Gaps = 27/242 (11%)
Query: 68 VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP-PKQAKTVLAAPILEVSSPSS 126
+I+TT + S V + + TI + + +G+ A+ K T P ++V S
Sbjct: 29492 IIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR 29551
Query: 127 DSILVQWEAVYM---AIAFSVSIMRANGLGSIWKENTTNTSLT---FTSLEAGTLYTIKA 180
DS+ + WE + A + + + +K TT S T + L GT+Y +
Sbjct: 29552 DSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 29611
Query: 181 YAWNANRIPGDDSTCNQRTS------PRAPANIQVSFDSGALKASFSWAR-----AEGAF 229
N I G C + P PA ++V D + +W +
Sbjct: 29612 LPEN---IYGIGEPCETSDAVLVSEVPLVPAKLEV-VDVTKSTVTLAWEKPLYDGGSRLT 29667
Query: 230 NYTVMALSDSSE-----LTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLK 284
Y + A +E +T T T++SL G +YL + A N+ G S+ +T
Sbjct: 29668 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 29727
Query: 285 TV 286
TV
Sbjct: 29728 TV 29729
Score = 38.1 bits (87), Expect = 0.029
Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 18/123 (14%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSA---MTLKTVACAPGRVTIQEDPPGHLSVAWS- 308
++ L G EY A N AG SK+S A + + APGR + + +S+ WS
Sbjct: 28902 VTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSA 28961
Query: 309 -SVDLGDYYVVFV-------KSDDGLEVHCNTSLTQCNF-----LSECGFTYFISVFVYN 355
+ D G V ++ + DG + CN ++ NF LSE G TY V N
Sbjct: 28962 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSE-GDTYEFRVLAKN 29020
Query: 356 KAG 358
AG
Sbjct: 29021 AAG 29023
Score = 37.7 bits (86), Expect = 0.038
Identities = 86/369 (23%), Positives = 131/369 (35%), Gaps = 69/369 (18%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGH---------- 302
+S L G Y V A N AG K S + C P DPPG
Sbjct: 25648 VSGLDEGLMYEYRVYAENIAGIGKCSKS-------CEPVPARDPCDPPGQPEVTNITRKS 25700
Query: 303 LSVAWSS------VDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFT----YFISVF 352
+S+ WS + Y V + DG + CN + Q + T Y VF
Sbjct: 25701 VSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF 25760
Query: 353 VYNKAGQSPLGDIFNYTTAPCCPSDINP------------VLVSSDRVEIVWSPVRGAEL 400
N A + + T D+ P ++V + V + + + G L
Sbjct: 25761 ARNAADS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPL 25818
Query: 401 YETK-AVDGYNMVECNDTTPACT-----LSALEC---DT-KYNITVYSFNEVRGSNMSCT 450
A DG + E T T L+ +C DT +Y +T+ + R ++C
Sbjct: 25819 PVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 25878
Query: 451 PQFITTAPCSP-EIKNVSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKGLYQCSSTG 504
P P EI ++ + S+ W +D Y V + L G
Sbjct: 25879 VLDKPGPPAGPLEINGLTAEKCSL---SWGRPQEDGGADIDYYIVEKRETSHLAWTICEG 25935
Query: 505 E----SCTMRGLPCGS--VFSVTAVAETQAGRSLPSYSVPLE---TVPCCPTGLTVTQIT 555
E SC + L G+ +F VT V + G L S ++ TVP PT L +T +T
Sbjct: 25936 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 25995
Query: 556 QSVINVSWT 564
+ + + W+
Sbjct: 25996 KESMTLCWS 26004
Score = 36.6 bits (83), Expect = 0.085
Identities = 83/390 (21%), Positives = 134/390 (34%), Gaps = 58/390 (14%)
Query: 56 TSYLLTAEDGDTVIETTVANSPGT-----VTGLKAATWYEITIRSISAAG---RSQASPP 107
T YLL + V T V P TGL+ T YE + +I+ AG S AS
Sbjct: 19520 TGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKA 19579
Query: 108 KQAKTVLAAP----ILEVSSPSSDSILVQW-----EAVYMAIAFSVSIMRA---NGLGSI 155
A+ P +V + S+ + W + I + V + RA N +
Sbjct: 19580 AYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCN 19639
Query: 156 WKENTTNTSLTFTSLEAGTLYTIKAYAWNA-----------NRIPGD---------DSTC 195
+N T T L T Y + YA N P D D+
Sbjct: 19640 LPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADL 19699
Query: 196 NQRTSPRAPANIQVSFD-SGALKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTIS 254
+ RA +++ G +W++ + S++ TF C
Sbjct: 19700 RKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDF---DTFLRCENV 19756
Query: 255 SLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDL 312
+ +Y++++ N G + + + + P VT++E V W +D
Sbjct: 19757 NKYDAGKYILTL--ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDG 19814
Query: 313 GDYYVVF-VKSDDGLEVHCNTSLTQCNFLS------ECGFTYFISVFVYNKAGQSPLGDI 365
G + + V+ D +T T+C+ S E G +YF VF N+ G G+
Sbjct: 19815 GSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGET 19874
Query: 366 FNYTTAPCCPS---DINPVLVSSDRVEIVW 392
+ A P D+ VS I W
Sbjct: 19875 RDAVKASQTPGPVVDLKVRSVSKSSCSIGW 19904
Score = 36.6 bits (83), Expect = 0.085
Identities = 104/471 (22%), Positives = 156/471 (33%), Gaps = 97/471 (20%)
Query: 168 TSLEAGTLYTIKAYAWNANRIPGDDSTCNQ---RTSPRAPANIQVSFDSGALKASFSWAR 224
T L G Y + A N I T +P P ++ + D S +W +
Sbjct: 20929 TGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNI-MDITKSTVSLAWPK 20987
Query: 225 A--EGAFNYTVMALS----DSSELTCSTTFSS--CTISSLQCGTEYLISVLASNDAGSS- 275
+G T + S + T TT C + +L G EY V+A N AG S
Sbjct: 20988 PKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSA 21047
Query: 276 -KSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYY--VVFVKSDDGLEVHCNT 332
+ S + +K P +DL Y +V K+ D ++V
Sbjct: 21048 PRESRPVIVKEQTMLP------------------ELDLRGIYQKLVIAKAGDNIKVEIPV 21089
Query: 333 ------------------SLTQCNFLSECGFTYF-ISVFVYNKAGQSPL---------GD 364
+ NF + T I+ V + +G PL GD
Sbjct: 21090 LGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGD 21149
Query: 365 IFNYTTAPCCPSDINPVL---VSSDRVEIVWSPVRGAE-------LYETKAVDGYNMVEC 414
+ P+ VSSD V W P + E + D VE
Sbjct: 21150 VITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVEL 21209
Query: 415 NDTTPACTLSALECDT--KYNITVYSFNEVR---GSNMSCT----PQFITTAPCSPEIKN 465
T T A T +Y V + N G +C P + P +P++
Sbjct: 21210 ATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTA 21269
Query: 466 VSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKG-LYQCSST----GESCTMRGLPCG 515
V++D+ + + W D Y V + G L+Q S G GL G
Sbjct: 21270 VTKDSMT---ISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDG 21326
Query: 516 SVFSVTAVAETQAGRSLPSY-SVPLETV-PCCPTGLTV-TQITQSVINVSW 563
+ +AE AG+S PS S P+ + P P G V IT+ + + W
Sbjct: 21327 IAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLKW 21377
Score = 36.2 bits (82), Expect = 0.11
Identities = 68/279 (24%), Positives = 101/279 (36%), Gaps = 42/279 (15%)
Query: 42 SNSITVEW--ATVPGA---TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEIT 92
+ SIT+ W G T+Y++ D T V+ TVA + VT LK T Y+
Sbjct: 23337 AESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFR 23396
Query: 93 IRSISAAGRSQASPPKQAKTVLAAPILEVSSP--------SSDSILVQWEAVY-----MA 139
I + + G+S A + V P E P S DS+++QW
Sbjct: 23397 IFAENRYGQSFAL--ESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPV 23454
Query: 140 IAFSVSIMRANGLGSIW-KENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDS 193
I + + N + +W K N T +T +LE G Y + YA N + +S
Sbjct: 23455 IGYHLERKERNSI--LWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNS 23512
Query: 194 TCNQRTSPRAPANIQVSFDSGALKASFSWARA--EGAFNYT-----VMALSDSSELTCST 246
C P P + + W + +G T L D + S
Sbjct: 23513 ECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASF 23572
Query: 247 T---FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMT 282
T + T+S L Y V+A N AG+ S T
Sbjct: 23573 TNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDST 23611
Score = 35.4 bits (80), Expect = 0.19
Identities = 105/478 (21%), Positives = 169/478 (35%), Gaps = 71/478 (14%)
Query: 119 LEVSSPSSDSILVQWEAVYMAIAFSVS---IMRANGLGSIW----KENTTNTSLTFTSLE 171
LE++S + +S+ + W +S I R W K+ + + T L
Sbjct: 25989 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLR 26048
Query: 172 AGTLYTIKAYAWNAN--RIPGDDSTCNQRTSP---RAPANIQVSFDSGALKASFSWARA- 225
G Y + YA NA +P + S + P +P + DSG + +W +
Sbjct: 26049 EGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPL 26108
Query: 226 --EGA--FNYTVMALSDSSELTCSTTFSSC-----TISSLQCGTEYLISVLASNDAGSSK 276
GA YTV S + T+ S TIS L G EY+ V + N G+S
Sbjct: 26109 FDGGAPITGYTV-EYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASD 26167
Query: 277 SSSA----------------------MTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGD 314
S + TL A A +T+ +V WS D
Sbjct: 26168 PSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL 26227
Query: 315 YYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCC 374
+V + D TSLT N Y ++ + N + L + P
Sbjct: 26228 RTRAYVDTTDS-----RTSLTIENANRNDSGKYTLT--IQNVLSAASLTLVVKVLDTPGP 26280
Query: 375 PSDINPVLVSSDRVEIVW--------SPVRGAELYETKA-VDGYNMVECNDTTPACTLSA 425
P++I V+ + + W +PV+ + + +A + V N + ++
Sbjct: 26281 PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTN 26340
Query: 426 LECDTKYNITVYSFNEVRGSNMSCTPQ--FITTAPCSPEIKNVSRDAFSMINVHWRSTND 483
L+ Y V NE + T + IT P PE V+ + +++ W
Sbjct: 26341 LQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEH 26400
Query: 484 D-----ATYTVTA--QGEKGLYQCS-STGESCTMRGLPCGSVFSVTAVAETQAGRSLP 533
D Y V A +G+K +C+ + + GL S + AE QAG S P
Sbjct: 26401 DGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDP 26458
Score = 35.0 bits (79), Expect = 0.25
Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 10/127 (7%)
Query: 159 NTTNTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFDSGAL 216
N T T+ +L+ G Y + A N I P + + + + P P D
Sbjct: 25251 NCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 25310
Query: 217 KASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCT--------ISSLQCGTEYLISVLA 268
A+ W + E + + S +S+CT IS L G EY+ V A
Sbjct: 25311 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAA 25370
Query: 269 SNDAGSS 275
N+ G S
Sbjct: 25371 VNEKGRS 25377
Score = 33.1 bits (74), Expect = 0.94
Identities = 39/165 (23%), Positives = 61/165 (36%), Gaps = 25/165 (15%)
Query: 169 SLEAGTLYTIK--------AYAWNANRIPGDDST---CNQRTSPRAPANIQVSFDSGALK 217
S + TL T+K Y + G S C P PA A K
Sbjct: 25840 STDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEK 25899
Query: 218 ASFSWARAE---GA-FNYTVMALSDSSELTCSTT-----FSSCTISSLQCGTEYLISVLA 268
S SW R + GA +Y ++ ++S L + +SC ++ L G EY+ V
Sbjct: 25900 CSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTG 25959
Query: 269 SNDAGSSKSSSAMTLK-----TVACAPGRVTIQEDPPGHLSVAWS 308
N G + ++ +K TV P + I +++ WS
Sbjct: 25960 VNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWS 26004
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 7/72 (9%)
Query: 70 ETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP---PKQAKTVLAAPI----LEVS 122
+T + + TVTGL Y+ I + + G S+ SP P K P LE+
Sbjct: 30381 KTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEIL 30440
Query: 123 SPSSDSILVQWE 134
S S DS+ +QWE
Sbjct: 30441 SISKDSVTLQWE 30452
Score = 32.7 bits (73), Expect = 1.2
Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 17/179 (9%)
Query: 402 ETKAVDGYNMVECNDTTPACTLSALECDT-KYNITVYSFNEVRGSNMSCTPQFITTAPCS 460
E K + Y + N ++ + L DT +Y ITV + + + T + P
Sbjct: 17550 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG 17609
Query: 461 PEIKNVSRDAFSMINVHWRSTNDDA-----TYTVTAQG-EKGLYQCSSTGESCTMRGLP- 513
P N+ + + W+ DD Y V Q K + S+G S T +P
Sbjct: 17610 PI--NILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 17667
Query: 514 ----CGSVFSVTAVAETQAGRSL---PSYSVPLETVPCCPTGLTVTQITQSVINVSWTI 565
C VF V A + G L P+ + + P P VT IT++ VSWT+
Sbjct: 17668 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 17726
Score = 32.3 bits (72), Expect = 1.6
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 18/122 (14%)
Query: 28 APEIPTIDQAYSKLSNSITVEWATVPGATS----YLLTAEDGDTVIETTVANS-----PG 78
AP+ P ++ SNS+ V+W S Y L + ++ + V S
Sbjct: 14905 APDKPIVEDV---TSNSMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA 14961
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTV------LAAPILEVSSPSSDSILVQ 132
V GL Y + + +AAG + SPP KT PI V+ SS +I ++
Sbjct: 14962 NVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELE 15021
Query: 133 WE 134
WE
Sbjct: 15022 WE 15023
Score = 31.6 bits (70), Expect = 2.7
Identities = 23/91 (25%), Positives = 41/91 (45%), Gaps = 10/91 (10%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDT-----VIETTVANSPG 78
P P I + NS+TV W+ + Y L D + V++ T+ ++
Sbjct: 27066 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ 27125
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQ 109
VTGL + Y+ + +++AAG+ S P +
Sbjct: 27126 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSE 27156
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 514 CGSVFSVTAVAETQAGRSLPSYS---VPLETVPCCPTGLTVTQITQSVINVSWT 564
C F VTA E + G LP+ + + + VP P +TV +T++ +++SWT
Sbjct: 23101 CSYYFRVTA--ENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWT 23152
Score = 30.8 bits (68), Expect = 4.7
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 26/192 (13%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDTVIETTVANSPGT---- 79
P PT + Y +N++++ W Y + ++ +T++ P
Sbjct: 28841 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 28900
Query: 80 -VTGLKAATWYEITIRSISAAG---RSQASPPKQAKTVLAAP-ILEVSSPSSDSILVQWE 134
VTGL Y+ +++AAG S+AS P A+ + AP EV+ + ++ + W
Sbjct: 28901 KVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWS 28960
Query: 135 A-------VYMAIAFSVSIMRANGLGSIWKENTTNTS---LTFTSLEAGTLYTIKAYAWN 184
A + + G G K N T S T T+L G Y + A N
Sbjct: 28961 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKN 29020
Query: 185 ANRI--PGDDST 194
A + G +ST
Sbjct: 29021 AAGVISKGSEST 29032
Score = 30.0 bits (66), Expect = 8.0
Identities = 16/63 (25%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 249 SSCTISSLQCGTEYLISVLASNDAG---SSKSSSAMTLKTVACAPGRVTIQEDPPGHLSV 305
+S I LQ G Y V A N+ G ++++ + + V PG++T+ + +S+
Sbjct: 23090 NSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSL 23149
Query: 306 AWS 308
+W+
Sbjct: 23150 SWT 23152
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 50.1 bits (118), Expect = 7e-06
Identities = 100/423 (23%), Positives = 152/423 (35%), Gaps = 64/423 (15%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEW--------ATVPG-ATSYLLTAEDGDTVIETTVANSP 77
S P+ P + NS T+ W A + G TSY + D E +V
Sbjct: 12492 SEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDL 12551
Query: 78 G-TVTGLKAATWYEITIRSISAAGRS---QASPPKQAKTVLAAPILEVSSPSSDSILVQW 133
VTGLK Y+ + + +A G S +A +AK L P ++ P +I
Sbjct: 12552 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPP--KILMPEQITIKAGK 12609
Query: 134 EAVYMAIAFSVSIMRANGLGSIWK----ENTTNTSLTFTSLEAGTLYTIKA--------Y 181
+ A + WK E T++ L ++ ++ IK Y
Sbjct: 12610 KLRIEAHVYGKPHPTCK-----WKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYY 12664
Query: 182 AWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKA---SFSWA-----RAEGAFNYTV 233
+ A G D+ + AP Q FD + A S SW NY V
Sbjct: 12665 SLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIV 12724
Query: 234 ----MALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKT---- 285
++ D S T +SC + L G EY+ V A N G S+ ++ +
Sbjct: 12725 EKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPF 12784
Query: 286 -VACAPGRVTIQEDPPGHLSVAWSSVD------LGDYYVVFVKSDDGLEVHCNTSLTQ-- 336
V P + + + VAW D + Y + + + L V N +L +
Sbjct: 12785 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRST 12844
Query: 337 ---CNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTA--PCCPSDINPVL-VSSDRVEI 390
C L E G Y ++ NKAG SP Y TA P P V+ V+ V +
Sbjct: 12845 EYPCAGLVE-GLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSL 12903
Query: 391 VWS 393
+W+
Sbjct: 12904 IWA 12906
Score = 47.8 bits (112), Expect = 4e-05
Identities = 84/426 (19%), Positives = 164/426 (38%), Gaps = 69/426 (16%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEWATVPG-----ATSYLLTAEDGDT------VIETTVAN 75
+ P+ P I + + NSIT+ WA Y+L + + + + ++
Sbjct: 21845 TVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISE 21904
Query: 76 SPGTVTGLKAATWYEITIRSISAAGRSQASPPKQ---AKTVLAAP----ILEVSSPSSDS 128
+ VTGL YE + + +AAG AS + + + P +++V+ S +
Sbjct: 21905 TRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTT 21964
Query: 129 ILVQWEAVYM-----AIAFSVSIMRANGLGSIWKENT---TNTSLTFTSLEAGTLYTIKA 180
+ ++W I + + + +A+ LG K N T T T L+AG Y +
Sbjct: 21965 VSLEWSKPVFDGGMEIIGYIIEMCKAD-LGDWHKVNAEACVKTRYTVTDLQAGEEYKFRV 22023
Query: 181 YAWNAN------RIPGDDSTCNQRTSP--------------RAPANIQVSFD-SGALKAS 219
A N + G ++ T+P RA A+I++ G +
Sbjct: 22024 SAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPT 22083
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W++ + LS +++ + +FS+ T+ + ++ N++GS +
Sbjct: 22084 AVWSKPDSN-------LSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITF 22136
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLG---DYYVV-----FVKSDDGLEVH 329
+ + PG +T ++ G ++ W + +D G +YVV +S +
Sbjct: 22137 TVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEK 22196
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAGQS---PLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + N L+E G Y+ V N+ G + + T P P ++ V S
Sbjct: 22197 CTRQIFKVNDLAE-GVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKS 22255
Query: 387 RVEIVW 392
+ W
Sbjct: 22256 SAVLAW 22261
Score = 46.2 bits (108), Expect = 1e-04
Identities = 93/435 (21%), Positives = 153/435 (35%), Gaps = 74/435 (17%)
Query: 24 SAKSAPEIPTIDQAYSKLSNSITVEWATVP-----GATSYLLTAEDGDTVIETTVANSP- 77
S AP+ PT+ S NS+TV W T Y L +D + V P
Sbjct: 10010 SVPGAPDKPTVS---SVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPI 10066
Query: 78 --------GTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVL------AAPILEVSS 123
VTGL + Y+ + +I+AAG AS P T P +V+
Sbjct: 10067 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTD 10126
Query: 124 PSSDSILVQWEAVYMAIAFSVS--IMRANGLG-SIWK----ENTTNTSLTFTSLEAGTLY 176
+ S ++W V+ I+ G W+ + T L T L+ G Y
Sbjct: 10127 WTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFY 10186
Query: 177 TIKAYAWNANRI--PGD------------------DSTCNQRTSPRAPANIQ-VSFDSGA 215
+ A N I PG+ D++ R A I+ +++ SG
Sbjct: 10187 KFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 10246
Query: 216 LKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSS 275
+ +W N L + + + SS I + Q + + S+LA N+AG
Sbjct: 10247 PPPTVTW-------NMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGER 10299
Query: 276 KSSSAMTLKTVACAPGRVTIQEDPPGH-LSVAWSSVD------LGDYYVVFVKSDDGLEV 328
K + + + V G + + + W S + + +Y + +SD
Sbjct: 10300 KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWT 10359
Query: 329 HCNTSLTQCNFLSE---CGFTYFISVFVYNKAGQSPLGD------IFNYTTAPCCPSDIN 379
++T+ N + G YF + N G P + I T P P D+
Sbjct: 10360 PVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLE 10419
Query: 380 PVLVSSDRVEIVWSP 394
V+ + V + W+P
Sbjct: 10420 VKEVTKNTVTLTWNP 10434
Score = 41.2 bits (95), Expect = 0.003
Identities = 102/484 (21%), Positives = 185/484 (38%), Gaps = 83/484 (17%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV--PGATS---YLLTAEDGDTVIET-----TVANSPG 78
P P+ + + +S+ V WA G T Y+L D + V T T+ +
Sbjct: 18597 PGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRL 18656
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAP----ILEVSSPSSDSILV 131
VTGL YE + + +AAG + S P +A L P +V+ S S+ +
Sbjct: 18657 RVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSL 18716
Query: 132 QW-EAVYMAIA----FSVSIMRANGLGSIWKENTTNTSL-----TFTSLEAGTLYTIKAY 181
W + +Y A + V + A W T T L T T L+ T Y +
Sbjct: 18717 AWSKPIYDGGAPVKGYVVEVKEA--AADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRIC 18774
Query: 182 AWNANRIPGDDST------CNQRTSP---------------RAPANIQVSFD-SGALKAS 219
A N+ + G+ +T +R P RA A +++ G +
Sbjct: 18775 AINSEGV-GEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPE 18833
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W +AEG L+D +++ +++F+ I ++ ++ N++GS +
Sbjct: 18834 VKWEKAEG-------ILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFV 18886
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--------KSDDGLEVH 329
+ + AP +TI+E ++++W +D G ++ K+ + +
Sbjct: 18887 NVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNN 18946
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAG---QSPLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + L E G +Y+ V N+ G + + + P P + V V+ +
Sbjct: 18947 CTKTTFRIENLQE-GCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 19005
Query: 387 RVEIVW--------SPVRGAEL-YETKAVDGYNMVECNDTTPACTLSALECDTKYNITVY 437
I W S + G + +TK + ++ T A T+S L +Y V
Sbjct: 19006 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA-TISGLTAGEEYVFRVA 19064
Query: 438 SFNE 441
+ NE
Sbjct: 19065 AVNE 19068
Score = 40.8 bits (94), Expect = 0.005
Identities = 129/605 (21%), Positives = 217/605 (35%), Gaps = 114/605 (18%)
Query: 56 TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAK 111
++Y++ D T ++ TVA + +T LK T Y+ I + + G+S +P
Sbjct: 18133 SNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKS--APLDSKA 18190
Query: 112 TVLAAPILE--------VSSPSSDSILVQW-----EAVYMAIAFSVSIMRANGLGSIW-K 157
++ P E V+S S D +LVQW + I + + N + +W K
Sbjct: 18191 VIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSI--LWVK 18248
Query: 158 ENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFD 212
N T +T T L+ G Y K A N I P S C P P +
Sbjct: 18249 LNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIV 18308
Query: 213 SGALKASFSWARA--EGAFNYT-----VMALSDSSELTCSTT---FSSCTISSLQCGTEY 262
+ W + +G T L D + S T + T+S L Y
Sbjct: 18309 ITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRY 18368
Query: 263 LISVLASNDAGS----SKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYYVV 318
V+A N AG+ S SS A+T + AP P + V V G+ +V+
Sbjct: 18369 EFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASL----DPKYKDVI--VVHAGETFVL 18422
Query: 319 -----------FVKSDDGLEVH------------CNTSLTQCNFLSECGFTYFISVFVYN 355
V S DG E+ T+L + + G Y + + N
Sbjct: 18423 EADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILK--LSN 18480
Query: 356 KAGQSPLGDIFNYTTAPCCP-SDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVEC 414
G + P P + V++++ + W+P L + A + ++E
Sbjct: 18481 VGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNP----PLQDGGANISHYIIEK 18536
Query: 415 NDT-----TPACT--------LSALECDTKYNITVYSFNEV-------RGSNMSCTPQFI 454
+T T T ++ L +Y V + N+ G +C P
Sbjct: 18537 RETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKP 18596
Query: 455 TTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT----YTVTAQGEKGLYQCSSTGESCT-- 508
P +PE+ +++D SM+ R +D T Y + + ++G+ ++ T
Sbjct: 18597 PGPPSTPEVSAITKD--SMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDL 18654
Query: 509 ---MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETV------PCCPTGLTVTQITQSVI 559
+ GL G + AE AG PS P P+ VT ++S +
Sbjct: 18655 RLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSV 18714
Query: 560 NVSWT 564
+++W+
Sbjct: 18715 SLAWS 18719
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/242 (23%), Positives = 94/242 (38%), Gaps = 27/242 (11%)
Query: 68 VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP-PKQAKTVLAAPILEVSSPSS 126
+I+TT + S V + + TI + + +G+ A+ K T P ++V S
Sbjct: 23187 IIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR 23246
Query: 127 DSILVQWEAVYM---AIAFSVSIMRANGLGSIWKENTTNTSLT---FTSLEAGTLYTIKA 180
DS+ + WE + A + + + +K TT S T + L GT+Y +
Sbjct: 23247 DSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 23306
Query: 181 YAWNANRIPGDDSTCNQRTS------PRAPANIQVSFDSGALKASFSWAR-----AEGAF 229
N I G C + P PA ++V D + +W +
Sbjct: 23307 LPEN---IYGIGEPCETSDAVLVSEVPLVPAKLEV-VDVTKSTVTLAWEKPLYDGGSRLT 23362
Query: 230 NYTVMALSDSSE-----LTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLK 284
Y + A +E +T T T++SL G +YL + A N+ G S+ +T
Sbjct: 23363 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23422
Query: 285 TV 286
TV
Sbjct: 23423 TV 23424
Score = 38.1 bits (87), Expect = 0.029
Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 18/123 (14%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSA---MTLKTVACAPGRVTIQEDPPGHLSVAWS- 308
++ L G EY A N AG SK+S A + + APGR + + +S+ WS
Sbjct: 22597 VTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSA 22656
Query: 309 -SVDLGDYYVVFV-------KSDDGLEVHCNTSLTQCNF-----LSECGFTYFISVFVYN 355
+ D G V ++ + DG + CN ++ NF LSE G TY V N
Sbjct: 22657 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSE-GDTYEFRVLAKN 22715
Query: 356 KAG 358
AG
Sbjct: 22716 AAG 22718
Score = 37.7 bits (86), Expect = 0.038
Identities = 86/369 (23%), Positives = 131/369 (35%), Gaps = 69/369 (18%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGH---------- 302
+S L G Y V A N AG K S + C P DPPG
Sbjct: 19343 VSGLDEGLMYEYRVYAENIAGIGKCSKS-------CEPVPARDPCDPPGQPEVTNITRKS 19395
Query: 303 LSVAWSS------VDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFT----YFISVF 352
+S+ WS + Y V + DG + CN + Q + T Y VF
Sbjct: 19396 VSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF 19455
Query: 353 VYNKAGQSPLGDIFNYTTAPCCPSDINP------------VLVSSDRVEIVWSPVRGAEL 400
N A + + T D+ P ++V + V + + + G L
Sbjct: 19456 ARNAADS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPL 19513
Query: 401 YETK-AVDGYNMVECNDTTPACT-----LSALEC---DT-KYNITVYSFNEVRGSNMSCT 450
A DG + E T T L+ +C DT +Y +T+ + R ++C
Sbjct: 19514 PVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 19573
Query: 451 PQFITTAPCSP-EIKNVSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKGLYQCSSTG 504
P P EI ++ + S+ W +D Y V + L G
Sbjct: 19574 VLDKPGPPAGPLEINGLTAEKCSL---SWGRPQEDGGADIDYYIVEKRETSHLAWTICEG 19630
Query: 505 E----SCTMRGLPCGS--VFSVTAVAETQAGRSLPSYSVPLE---TVPCCPTGLTVTQIT 555
E SC + L G+ +F VT V + G L S ++ TVP PT L +T +T
Sbjct: 19631 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 19690
Query: 556 QSVINVSWT 564
+ + + W+
Sbjct: 19691 KESMTLCWS 19699
Score = 36.6 bits (83), Expect = 0.085
Identities = 83/390 (21%), Positives = 134/390 (34%), Gaps = 58/390 (14%)
Query: 56 TSYLLTAEDGDTVIETTVANSPGT-----VTGLKAATWYEITIRSISAAG---RSQASPP 107
T YLL + V T V P TGL+ T YE + +I+ AG S AS
Sbjct: 13215 TGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKA 13274
Query: 108 KQAKTVLAAP----ILEVSSPSSDSILVQW-----EAVYMAIAFSVSIMRA---NGLGSI 155
A+ P +V + S+ + W + I + V + RA N +
Sbjct: 13275 AYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCN 13334
Query: 156 WKENTTNTSLTFTSLEAGTLYTIKAYAWNA-----------NRIPGD---------DSTC 195
+N T T L T Y + YA N P D D+
Sbjct: 13335 LPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADL 13394
Query: 196 NQRTSPRAPANIQVSFD-SGALKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTIS 254
+ RA +++ G +W++ + S++ TF C
Sbjct: 13395 RKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDF---DTFLRCENV 13451
Query: 255 SLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDL 312
+ +Y++++ N G + + + + P VT++E V W +D
Sbjct: 13452 NKYDAGKYILTL--ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDG 13509
Query: 313 GDYYVVF-VKSDDGLEVHCNTSLTQCNFLS------ECGFTYFISVFVYNKAGQSPLGDI 365
G + + V+ D +T T+C+ S E G +YF VF N+ G G+
Sbjct: 13510 GSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGET 13569
Query: 366 FNYTTAPCCPS---DINPVLVSSDRVEIVW 392
+ A P D+ VS I W
Sbjct: 13570 RDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13599
Score = 36.6 bits (83), Expect = 0.085
Identities = 104/471 (22%), Positives = 156/471 (33%), Gaps = 97/471 (20%)
Query: 168 TSLEAGTLYTIKAYAWNANRIPGDDSTCNQ---RTSPRAPANIQVSFDSGALKASFSWAR 224
T L G Y + A N I T +P P ++ + D S +W +
Sbjct: 14624 TGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNI-MDITKSTVSLAWPK 14682
Query: 225 A--EGAFNYTVMALS----DSSELTCSTTFSS--CTISSLQCGTEYLISVLASNDAGSS- 275
+G T + S + T TT C + +L G EY V+A N AG S
Sbjct: 14683 PKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSA 14742
Query: 276 -KSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYY--VVFVKSDDGLEVHCNT 332
+ S + +K P +DL Y +V K+ D ++V
Sbjct: 14743 PRESRPVIVKEQTMLP------------------ELDLRGIYQKLVIAKAGDNIKVEIPV 14784
Query: 333 ------------------SLTQCNFLSECGFTYF-ISVFVYNKAGQSPL---------GD 364
+ NF + T I+ V + +G PL GD
Sbjct: 14785 LGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGD 14844
Query: 365 IFNYTTAPCCPSDINPVL---VSSDRVEIVWSPVRGAE-------LYETKAVDGYNMVEC 414
+ P+ VSSD V W P + E + D VE
Sbjct: 14845 VITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVEL 14904
Query: 415 NDTTPACTLSALECDT--KYNITVYSFNEVR---GSNMSCT----PQFITTAPCSPEIKN 465
T T A T +Y V + N G +C P + P +P++
Sbjct: 14905 ATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTA 14964
Query: 466 VSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKG-LYQCSST----GESCTMRGLPCG 515
V++D+ + + W D Y V + G L+Q S G GL G
Sbjct: 14965 VTKDSMT---ISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDG 15021
Query: 516 SVFSVTAVAETQAGRSLPSY-SVPLETV-PCCPTGLTV-TQITQSVINVSW 563
+ +AE AG+S PS S P+ + P P G V IT+ + + W
Sbjct: 15022 IAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLKW 15072
Score = 36.2 bits (82), Expect = 0.11
Identities = 68/279 (24%), Positives = 101/279 (36%), Gaps = 42/279 (15%)
Query: 42 SNSITVEW--ATVPGA---TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEIT 92
+ SIT+ W G T+Y++ D T V+ TVA + VT LK T Y+
Sbjct: 17032 AESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFR 17091
Query: 93 IRSISAAGRSQASPPKQAKTVLAAPILEVSSP--------SSDSILVQWEAVY-----MA 139
I + + G+S A + V P E P S DS+++QW
Sbjct: 17092 IFAENRYGQSFAL--ESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPV 17149
Query: 140 IAFSVSIMRANGLGSIW-KENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDS 193
I + + N + +W K N T +T +LE G Y + YA N + +S
Sbjct: 17150 IGYHLERKERNSI--LWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNS 17207
Query: 194 TCNQRTSPRAPANIQVSFDSGALKASFSWARA--EGAFNYT-----VMALSDSSELTCST 246
C P P + + W + +G T L D + S
Sbjct: 17208 ECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASF 17267
Query: 247 T---FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMT 282
T + T+S L Y V+A N AG+ S T
Sbjct: 17268 TNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDST 17306
Score = 35.4 bits (80), Expect = 0.19
Identities = 105/478 (21%), Positives = 169/478 (35%), Gaps = 71/478 (14%)
Query: 119 LEVSSPSSDSILVQWEAVYMAIAFSVS---IMRANGLGSIW----KENTTNTSLTFTSLE 171
LE++S + +S+ + W +S I R W K+ + + T L
Sbjct: 19684 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLR 19743
Query: 172 AGTLYTIKAYAWNAN--RIPGDDSTCNQRTSP---RAPANIQVSFDSGALKASFSWARA- 225
G Y + YA NA +P + S + P +P + DSG + +W +
Sbjct: 19744 EGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPL 19803
Query: 226 --EGA--FNYTVMALSDSSELTCSTTFSSC-----TISSLQCGTEYLISVLASNDAGSSK 276
GA YTV S + T+ S TIS L G EY+ V + N G+S
Sbjct: 19804 FDGGAPITGYTV-EYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASD 19862
Query: 277 SSSA----------------------MTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGD 314
S + TL A A +T+ +V WS D
Sbjct: 19863 PSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL 19922
Query: 315 YYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCC 374
+V + D TSLT N Y ++ + N + L + P
Sbjct: 19923 RTRAYVDTTDS-----RTSLTIENANRNDSGKYTLT--IQNVLSAASLTLVVKVLDTPGP 19975
Query: 375 PSDINPVLVSSDRVEIVW--------SPVRGAELYETKA-VDGYNMVECNDTTPACTLSA 425
P++I V+ + + W +PV+ + + +A + V N + ++
Sbjct: 19976 PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTN 20035
Query: 426 LECDTKYNITVYSFNEVRGSNMSCTPQ--FITTAPCSPEIKNVSRDAFSMINVHWRSTND 483
L+ Y V NE + T + IT P PE V+ + +++ W
Sbjct: 20036 LQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEH 20095
Query: 484 D-----ATYTVTA--QGEKGLYQCS-STGESCTMRGLPCGSVFSVTAVAETQAGRSLP 533
D Y V A +G+K +C+ + + GL S + AE QAG S P
Sbjct: 20096 DGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDP 20153
Score = 35.0 bits (79), Expect = 0.25
Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 10/127 (7%)
Query: 159 NTTNTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFDSGAL 216
N T T+ +L+ G Y + A N I P + + + + P P D
Sbjct: 18946 NCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 19005
Query: 217 KASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCT--------ISSLQCGTEYLISVLA 268
A+ W + E + + S +S+CT IS L G EY+ V A
Sbjct: 19006 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAA 19065
Query: 269 SNDAGSS 275
N+ G S
Sbjct: 19066 VNEKGRS 19072
Score = 33.1 bits (74), Expect = 0.94
Identities = 39/165 (23%), Positives = 61/165 (36%), Gaps = 25/165 (15%)
Query: 169 SLEAGTLYTIK--------AYAWNANRIPGDDST---CNQRTSPRAPANIQVSFDSGALK 217
S + TL T+K Y + G S C P PA A K
Sbjct: 19535 STDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEK 19594
Query: 218 ASFSWARAE---GA-FNYTVMALSDSSELTCSTT-----FSSCTISSLQCGTEYLISVLA 268
S SW R + GA +Y ++ ++S L + +SC ++ L G EY+ V
Sbjct: 19595 CSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTG 19654
Query: 269 SNDAGSSKSSSAMTLK-----TVACAPGRVTIQEDPPGHLSVAWS 308
N G + ++ +K TV P + I +++ WS
Sbjct: 19655 VNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWS 19699
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 7/72 (9%)
Query: 70 ETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP---PKQAKTVLAAPI----LEVS 122
+T + + TVTGL Y+ I + + G S+ SP P K P LE+
Sbjct: 24076 KTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEIL 24135
Query: 123 SPSSDSILVQWE 134
S S DS+ +QWE
Sbjct: 24136 SISKDSVTLQWE 24147
Score = 32.7 bits (73), Expect = 1.2
Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 17/179 (9%)
Query: 402 ETKAVDGYNMVECNDTTPACTLSALECDT-KYNITVYSFNEVRGSNMSCTPQFITTAPCS 460
E K + Y + N ++ + L DT +Y ITV + + + T + P
Sbjct: 11245 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG 11304
Query: 461 PEIKNVSRDAFSMINVHWRSTNDDA-----TYTVTAQG-EKGLYQCSSTGESCTMRGLP- 513
P N+ + + W+ DD Y V Q K + S+G S T +P
Sbjct: 11305 PI--NILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 11362
Query: 514 ----CGSVFSVTAVAETQAGRSL---PSYSVPLETVPCCPTGLTVTQITQSVINVSWTI 565
C VF V A + G L P+ + + P P VT IT++ VSWT+
Sbjct: 11363 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11421
Score = 32.3 bits (72), Expect = 1.6
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 18/122 (14%)
Query: 28 APEIPTIDQAYSKLSNSITVEWATVPGATS----YLLTAEDGDTVIETTVANS-----PG 78
AP+ P ++ SNS+ V+W S Y L + ++ + V S
Sbjct: 8600 APDKPIVEDV---TSNSMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA 8656
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTV------LAAPILEVSSPSSDSILVQ 132
V GL Y + + +AAG + SPP KT PI V+ SS +I ++
Sbjct: 8657 NVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELE 8716
Query: 133 WE 134
WE
Sbjct: 8717 WE 8718
Score = 31.6 bits (70), Expect = 2.7
Identities = 23/91 (25%), Positives = 41/91 (45%), Gaps = 10/91 (10%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDT-----VIETTVANSPG 78
P P I + NS+TV W+ + Y L D + V++ T+ ++
Sbjct: 20761 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ 20820
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQ 109
VTGL + Y+ + +++AAG+ S P +
Sbjct: 20821 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSE 20851
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 514 CGSVFSVTAVAETQAGRSLPSYS---VPLETVPCCPTGLTVTQITQSVINVSWT 564
C F VTA E + G LP+ + + + VP P +TV +T++ +++SWT
Sbjct: 16796 CSYYFRVTA--ENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWT 16847
Score = 30.8 bits (68), Expect = 4.7
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 26/192 (13%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDTVIETTVANSPGT---- 79
P PT + Y +N++++ W Y + ++ +T++ P
Sbjct: 22536 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22595
Query: 80 -VTGLKAATWYEITIRSISAAG---RSQASPPKQAKTVLAAP-ILEVSSPSSDSILVQWE 134
VTGL Y+ +++AAG S+AS P A+ + AP EV+ + ++ + W
Sbjct: 22596 KVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWS 22655
Query: 135 A-------VYMAIAFSVSIMRANGLGSIWKENTTNTS---LTFTSLEAGTLYTIKAYAWN 184
A + + G G K N T S T T+L G Y + A N
Sbjct: 22656 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKN 22715
Query: 185 ANRI--PGDDST 194
A + G +ST
Sbjct: 22716 AAGVISKGSEST 22727
Score = 30.0 bits (66), Expect = 8.0
Identities = 16/63 (25%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 249 SSCTISSLQCGTEYLISVLASNDAG---SSKSSSAMTLKTVACAPGRVTIQEDPPGHLSV 305
+S I LQ G Y V A N+ G ++++ + + V PG++T+ + +S+
Sbjct: 16785 NSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSL 16844
Query: 306 AWS 308
+W+
Sbjct: 16845 SWT 16847
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 50.1 bits (118), Expect = 7e-06
Identities = 100/423 (23%), Positives = 152/423 (35%), Gaps = 64/423 (15%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEW--------ATVPG-ATSYLLTAEDGDTVIETTVANSP 77
S P+ P + NS T+ W A + G TSY + D E +V
Sbjct: 12425 SEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDL 12484
Query: 78 G-TVTGLKAATWYEITIRSISAAGRS---QASPPKQAKTVLAAPILEVSSPSSDSILVQW 133
VTGLK Y+ + + +A G S +A +AK L P ++ P +I
Sbjct: 12485 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPP--KILMPEQITIKAGK 12542
Query: 134 EAVYMAIAFSVSIMRANGLGSIWK----ENTTNTSLTFTSLEAGTLYTIKA--------Y 181
+ A + WK E T++ L ++ ++ IK Y
Sbjct: 12543 KLRIEAHVYGKPHPTCK-----WKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYY 12597
Query: 182 AWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKA---SFSWA-----RAEGAFNYTV 233
+ A G D+ + AP Q FD + A S SW NY V
Sbjct: 12598 SLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIV 12657
Query: 234 ----MALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKT---- 285
++ D S T +SC + L G EY+ V A N G S+ ++ +
Sbjct: 12658 EKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPF 12717
Query: 286 -VACAPGRVTIQEDPPGHLSVAWSSVD------LGDYYVVFVKSDDGLEVHCNTSLTQ-- 336
V P + + + VAW D + Y + + + L V N +L +
Sbjct: 12718 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRST 12777
Query: 337 ---CNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTA--PCCPSDINPVL-VSSDRVEI 390
C L E G Y ++ NKAG SP Y TA P P V+ V+ V +
Sbjct: 12778 EYPCAGLVE-GLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSL 12836
Query: 391 VWS 393
+W+
Sbjct: 12837 IWA 12839
Score = 47.8 bits (112), Expect = 4e-05
Identities = 84/426 (19%), Positives = 164/426 (38%), Gaps = 69/426 (16%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEWATVPG-----ATSYLLTAEDGDT------VIETTVAN 75
+ P+ P I + + NSIT+ WA Y+L + + + + ++
Sbjct: 21778 TVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISE 21837
Query: 76 SPGTVTGLKAATWYEITIRSISAAGRSQASPPKQ---AKTVLAAP----ILEVSSPSSDS 128
+ VTGL YE + + +AAG AS + + + P +++V+ S +
Sbjct: 21838 TRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTT 21897
Query: 129 ILVQWEAVYM-----AIAFSVSIMRANGLGSIWKENT---TNTSLTFTSLEAGTLYTIKA 180
+ ++W I + + + +A+ LG K N T T T L+AG Y +
Sbjct: 21898 VSLEWSKPVFDGGMEIIGYIIEMCKAD-LGDWHKVNAEACVKTRYTVTDLQAGEEYKFRV 21956
Query: 181 YAWNAN------RIPGDDSTCNQRTSP--------------RAPANIQVSFD-SGALKAS 219
A N + G ++ T+P RA A+I++ G +
Sbjct: 21957 SAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPT 22016
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W++ + LS +++ + +FS+ T+ + ++ N++GS +
Sbjct: 22017 AVWSKPDSN-------LSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITF 22069
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLG---DYYVV-----FVKSDDGLEVH 329
+ + PG +T ++ G ++ W + +D G +YVV +S +
Sbjct: 22070 TVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEK 22129
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAGQS---PLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + N L+E G Y+ V N+ G + + T P P ++ V S
Sbjct: 22130 CTRQIFKVNDLAE-GVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKS 22188
Query: 387 RVEIVW 392
+ W
Sbjct: 22189 SAVLAW 22194
Score = 46.2 bits (108), Expect = 1e-04
Identities = 93/435 (21%), Positives = 153/435 (35%), Gaps = 74/435 (17%)
Query: 24 SAKSAPEIPTIDQAYSKLSNSITVEWATVP-----GATSYLLTAEDGDTVIETTVANSP- 77
S AP+ PT+ S NS+TV W T Y L +D + V P
Sbjct: 9943 SVPGAPDKPTVS---SVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPI 9999
Query: 78 --------GTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVL------AAPILEVSS 123
VTGL + Y+ + +I+AAG AS P T P +V+
Sbjct: 10000 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTD 10059
Query: 124 PSSDSILVQWEAVYMAIAFSVS--IMRANGLG-SIWK----ENTTNTSLTFTSLEAGTLY 176
+ S ++W V+ I+ G W+ + T L T L+ G Y
Sbjct: 10060 WTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFY 10119
Query: 177 TIKAYAWNANRI--PGD------------------DSTCNQRTSPRAPANIQ-VSFDSGA 215
+ A N I PG+ D++ R A I+ +++ SG
Sbjct: 10120 KFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 10179
Query: 216 LKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSS 275
+ +W N L + + + SS I + Q + + S+LA N+AG
Sbjct: 10180 PPPTVTW-------NMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGER 10232
Query: 276 KSSSAMTLKTVACAPGRVTIQEDPPGH-LSVAWSSVD------LGDYYVVFVKSDDGLEV 328
K + + + V G + + + W S + + +Y + +SD
Sbjct: 10233 KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWT 10292
Query: 329 HCNTSLTQCNFLSE---CGFTYFISVFVYNKAGQSPLGD------IFNYTTAPCCPSDIN 379
++T+ N + G YF + N G P + I T P P D+
Sbjct: 10293 PVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLE 10352
Query: 380 PVLVSSDRVEIVWSP 394
V+ + V + W+P
Sbjct: 10353 VKEVTKNTVTLTWNP 10367
Score = 41.2 bits (95), Expect = 0.003
Identities = 102/484 (21%), Positives = 185/484 (38%), Gaps = 83/484 (17%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV--PGATS---YLLTAEDGDTVIET-----TVANSPG 78
P P+ + + +S+ V WA G T Y+L D + V T T+ +
Sbjct: 18530 PGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRL 18589
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAP----ILEVSSPSSDSILV 131
VTGL YE + + +AAG + S P +A L P +V+ S S+ +
Sbjct: 18590 RVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSL 18649
Query: 132 QW-EAVYMAIA----FSVSIMRANGLGSIWKENTTNTSL-----TFTSLEAGTLYTIKAY 181
W + +Y A + V + A W T T L T T L+ T Y +
Sbjct: 18650 AWSKPIYDGGAPVKGYVVEVKEA--AADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRIC 18707
Query: 182 AWNANRIPGDDST------CNQRTSP---------------RAPANIQVSFD-SGALKAS 219
A N+ + G+ +T +R P RA A +++ G +
Sbjct: 18708 AINSEGV-GEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPE 18766
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W +AEG L+D +++ +++F+ I ++ ++ N++GS +
Sbjct: 18767 VKWEKAEG-------ILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFV 18819
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--------KSDDGLEVH 329
+ + AP +TI+E ++++W +D G ++ K+ + +
Sbjct: 18820 NVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNN 18879
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAG---QSPLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + L E G +Y+ V N+ G + + + P P + V V+ +
Sbjct: 18880 CTKTTFRIENLQE-GCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 18938
Query: 387 RVEIVW--------SPVRGAEL-YETKAVDGYNMVECNDTTPACTLSALECDTKYNITVY 437
I W S + G + +TK + ++ T A T+S L +Y V
Sbjct: 18939 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA-TISGLTAGEEYVFRVA 18997
Query: 438 SFNE 441
+ NE
Sbjct: 18998 AVNE 19001
Score = 40.8 bits (94), Expect = 0.005
Identities = 129/605 (21%), Positives = 217/605 (35%), Gaps = 114/605 (18%)
Query: 56 TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAK 111
++Y++ D T ++ TVA + +T LK T Y+ I + + G+S +P
Sbjct: 18066 SNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKS--APLDSKA 18123
Query: 112 TVLAAPILE--------VSSPSSDSILVQW-----EAVYMAIAFSVSIMRANGLGSIW-K 157
++ P E V+S S D +LVQW + I + + N + +W K
Sbjct: 18124 VIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSI--LWVK 18181
Query: 158 ENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFD 212
N T +T T L+ G Y K A N I P S C P P +
Sbjct: 18182 LNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIV 18241
Query: 213 SGALKASFSWARA--EGAFNYT-----VMALSDSSELTCSTT---FSSCTISSLQCGTEY 262
+ W + +G T L D + S T + T+S L Y
Sbjct: 18242 ITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRY 18301
Query: 263 LISVLASNDAGS----SKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYYVV 318
V+A N AG+ S SS A+T + AP P + V V G+ +V+
Sbjct: 18302 EFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASL----DPKYKDVI--VVHAGETFVL 18355
Query: 319 -----------FVKSDDGLEVH------------CNTSLTQCNFLSECGFTYFISVFVYN 355
V S DG E+ T+L + + G Y + + N
Sbjct: 18356 EADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILK--LSN 18413
Query: 356 KAGQSPLGDIFNYTTAPCCP-SDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVEC 414
G + P P + V++++ + W+P L + A + ++E
Sbjct: 18414 VGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNP----PLQDGGANISHYIIEK 18469
Query: 415 NDT-----TPACT--------LSALECDTKYNITVYSFNEV-------RGSNMSCTPQFI 454
+T T T ++ L +Y V + N+ G +C P
Sbjct: 18470 RETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKP 18529
Query: 455 TTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT----YTVTAQGEKGLYQCSSTGESCT-- 508
P +PE+ +++D SM+ R +D T Y + + ++G+ ++ T
Sbjct: 18530 PGPPSTPEVSAITKD--SMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDL 18587
Query: 509 ---MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETV------PCCPTGLTVTQITQSVI 559
+ GL G + AE AG PS P P+ VT ++S +
Sbjct: 18588 RLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSV 18647
Query: 560 NVSWT 564
+++W+
Sbjct: 18648 SLAWS 18652
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/242 (23%), Positives = 94/242 (38%), Gaps = 27/242 (11%)
Query: 68 VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP-PKQAKTVLAAPILEVSSPSS 126
+I+TT + S V + + TI + + +G+ A+ K T P ++V S
Sbjct: 23120 IIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR 23179
Query: 127 DSILVQWEAVYM---AIAFSVSIMRANGLGSIWKENTTNTSLT---FTSLEAGTLYTIKA 180
DS+ + WE + A + + + +K TT S T + L GT+Y +
Sbjct: 23180 DSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 23239
Query: 181 YAWNANRIPGDDSTCNQRTS------PRAPANIQVSFDSGALKASFSWAR-----AEGAF 229
N I G C + P PA ++V D + +W +
Sbjct: 23240 LPEN---IYGIGEPCETSDAVLVSEVPLVPAKLEV-VDVTKSTVTLAWEKPLYDGGSRLT 23295
Query: 230 NYTVMALSDSSE-----LTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLK 284
Y + A +E +T T T++SL G +YL + A N+ G S+ +T
Sbjct: 23296 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23355
Query: 285 TV 286
TV
Sbjct: 23356 TV 23357
Score = 38.1 bits (87), Expect = 0.029
Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 18/123 (14%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSA---MTLKTVACAPGRVTIQEDPPGHLSVAWS- 308
++ L G EY A N AG SK+S A + + APGR + + +S+ WS
Sbjct: 22530 VTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSA 22589
Query: 309 -SVDLGDYYVVFV-------KSDDGLEVHCNTSLTQCNF-----LSECGFTYFISVFVYN 355
+ D G V ++ + DG + CN ++ NF LSE G TY V N
Sbjct: 22590 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSE-GDTYEFRVLAKN 22648
Query: 356 KAG 358
AG
Sbjct: 22649 AAG 22651
Score = 37.7 bits (86), Expect = 0.038
Identities = 86/369 (23%), Positives = 131/369 (35%), Gaps = 69/369 (18%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGH---------- 302
+S L G Y V A N AG K S + C P DPPG
Sbjct: 19276 VSGLDEGLMYEYRVYAENIAGIGKCSKS-------CEPVPARDPCDPPGQPEVTNITRKS 19328
Query: 303 LSVAWSS------VDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFT----YFISVF 352
+S+ WS + Y V + DG + CN + Q + T Y VF
Sbjct: 19329 VSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF 19388
Query: 353 VYNKAGQSPLGDIFNYTTAPCCPSDINP------------VLVSSDRVEIVWSPVRGAEL 400
N A + + T D+ P ++V + V + + + G L
Sbjct: 19389 ARNAADS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPL 19446
Query: 401 YETK-AVDGYNMVECNDTTPACT-----LSALEC---DT-KYNITVYSFNEVRGSNMSCT 450
A DG + E T T L+ +C DT +Y +T+ + R ++C
Sbjct: 19447 PVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 19506
Query: 451 PQFITTAPCSP-EIKNVSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKGLYQCSSTG 504
P P EI ++ + S+ W +D Y V + L G
Sbjct: 19507 VLDKPGPPAGPLEINGLTAEKCSL---SWGRPQEDGGADIDYYIVEKRETSHLAWTICEG 19563
Query: 505 E----SCTMRGLPCGS--VFSVTAVAETQAGRSLPSYSVPLE---TVPCCPTGLTVTQIT 555
E SC + L G+ +F VT V + G L S ++ TVP PT L +T +T
Sbjct: 19564 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 19623
Query: 556 QSVINVSWT 564
+ + + W+
Sbjct: 19624 KESMTLCWS 19632
Score = 36.6 bits (83), Expect = 0.085
Identities = 83/390 (21%), Positives = 134/390 (34%), Gaps = 58/390 (14%)
Query: 56 TSYLLTAEDGDTVIETTVANSPGT-----VTGLKAATWYEITIRSISAAG---RSQASPP 107
T YLL + V T V P TGL+ T YE + +I+ AG S AS
Sbjct: 13148 TGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKA 13207
Query: 108 KQAKTVLAAP----ILEVSSPSSDSILVQW-----EAVYMAIAFSVSIMRA---NGLGSI 155
A+ P +V + S+ + W + I + V + RA N +
Sbjct: 13208 AYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCN 13267
Query: 156 WKENTTNTSLTFTSLEAGTLYTIKAYAWNA-----------NRIPGD---------DSTC 195
+N T T L T Y + YA N P D D+
Sbjct: 13268 LPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADL 13327
Query: 196 NQRTSPRAPANIQVSFD-SGALKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTIS 254
+ RA +++ G +W++ + S++ TF C
Sbjct: 13328 RKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDF---DTFLRCENV 13384
Query: 255 SLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDL 312
+ +Y++++ N G + + + + P VT++E V W +D
Sbjct: 13385 NKYDAGKYILTL--ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDG 13442
Query: 313 GDYYVVF-VKSDDGLEVHCNTSLTQCNFLS------ECGFTYFISVFVYNKAGQSPLGDI 365
G + + V+ D +T T+C+ S E G +YF VF N+ G G+
Sbjct: 13443 GSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGET 13502
Query: 366 FNYTTAPCCPS---DINPVLVSSDRVEIVW 392
+ A P D+ VS I W
Sbjct: 13503 RDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13532
Score = 36.6 bits (83), Expect = 0.085
Identities = 104/471 (22%), Positives = 156/471 (33%), Gaps = 97/471 (20%)
Query: 168 TSLEAGTLYTIKAYAWNANRIPGDDSTCNQ---RTSPRAPANIQVSFDSGALKASFSWAR 224
T L G Y + A N I T +P P ++ + D S +W +
Sbjct: 14557 TGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNI-MDITKSTVSLAWPK 14615
Query: 225 A--EGAFNYTVMALS----DSSELTCSTTFSS--CTISSLQCGTEYLISVLASNDAGSS- 275
+G T + S + T TT C + +L G EY V+A N AG S
Sbjct: 14616 PKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSA 14675
Query: 276 -KSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYY--VVFVKSDDGLEVHCNT 332
+ S + +K P +DL Y +V K+ D ++V
Sbjct: 14676 PRESRPVIVKEQTMLP------------------ELDLRGIYQKLVIAKAGDNIKVEIPV 14717
Query: 333 ------------------SLTQCNFLSECGFTYF-ISVFVYNKAGQSPL---------GD 364
+ NF + T I+ V + +G PL GD
Sbjct: 14718 LGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGD 14777
Query: 365 IFNYTTAPCCPSDINPVL---VSSDRVEIVWSPVRGAE-------LYETKAVDGYNMVEC 414
+ P+ VSSD V W P + E + D VE
Sbjct: 14778 VITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVEL 14837
Query: 415 NDTTPACTLSALECDT--KYNITVYSFNEVR---GSNMSCT----PQFITTAPCSPEIKN 465
T T A T +Y V + N G +C P + P +P++
Sbjct: 14838 ATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTA 14897
Query: 466 VSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKG-LYQCSST----GESCTMRGLPCG 515
V++D+ + + W D Y V + G L+Q S G GL G
Sbjct: 14898 VTKDSMT---ISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDG 14954
Query: 516 SVFSVTAVAETQAGRSLPSY-SVPLETV-PCCPTGLTV-TQITQSVINVSW 563
+ +AE AG+S PS S P+ + P P G V IT+ + + W
Sbjct: 14955 IAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLKW 15005
Score = 36.2 bits (82), Expect = 0.11
Identities = 68/279 (24%), Positives = 101/279 (36%), Gaps = 42/279 (15%)
Query: 42 SNSITVEW--ATVPGA---TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEIT 92
+ SIT+ W G T+Y++ D T V+ TVA + VT LK T Y+
Sbjct: 16965 AESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFR 17024
Query: 93 IRSISAAGRSQASPPKQAKTVLAAPILEVSSP--------SSDSILVQWEAVY-----MA 139
I + + G+S A + V P E P S DS+++QW
Sbjct: 17025 IFAENRYGQSFAL--ESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPV 17082
Query: 140 IAFSVSIMRANGLGSIW-KENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDS 193
I + + N + +W K N T +T +LE G Y + YA N + +S
Sbjct: 17083 IGYHLERKERNSI--LWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNS 17140
Query: 194 TCNQRTSPRAPANIQVSFDSGALKASFSWARA--EGAFNYT-----VMALSDSSELTCST 246
C P P + + W + +G T L D + S
Sbjct: 17141 ECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASF 17200
Query: 247 T---FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMT 282
T + T+S L Y V+A N AG+ S T
Sbjct: 17201 TNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDST 17239
Score = 35.4 bits (80), Expect = 0.19
Identities = 105/478 (21%), Positives = 169/478 (35%), Gaps = 71/478 (14%)
Query: 119 LEVSSPSSDSILVQWEAVYMAIAFSVS---IMRANGLGSIW----KENTTNTSLTFTSLE 171
LE++S + +S+ + W +S I R W K+ + + T L
Sbjct: 19617 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLR 19676
Query: 172 AGTLYTIKAYAWNAN--RIPGDDSTCNQRTSP---RAPANIQVSFDSGALKASFSWARA- 225
G Y + YA NA +P + S + P +P + DSG + +W +
Sbjct: 19677 EGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPL 19736
Query: 226 --EGA--FNYTVMALSDSSELTCSTTFSSC-----TISSLQCGTEYLISVLASNDAGSSK 276
GA YTV S + T+ S TIS L G EY+ V + N G+S
Sbjct: 19737 FDGGAPITGYTV-EYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASD 19795
Query: 277 SSSA----------------------MTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGD 314
S + TL A A +T+ +V WS D
Sbjct: 19796 PSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL 19855
Query: 315 YYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCC 374
+V + D TSLT N Y ++ + N + L + P
Sbjct: 19856 RTRAYVDTTDS-----RTSLTIENANRNDSGKYTLT--IQNVLSAASLTLVVKVLDTPGP 19908
Query: 375 PSDINPVLVSSDRVEIVW--------SPVRGAELYETKA-VDGYNMVECNDTTPACTLSA 425
P++I V+ + + W +PV+ + + +A + V N + ++
Sbjct: 19909 PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTN 19968
Query: 426 LECDTKYNITVYSFNEVRGSNMSCTPQ--FITTAPCSPEIKNVSRDAFSMINVHWRSTND 483
L+ Y V NE + T + IT P PE V+ + +++ W
Sbjct: 19969 LQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEH 20028
Query: 484 D-----ATYTVTA--QGEKGLYQCS-STGESCTMRGLPCGSVFSVTAVAETQAGRSLP 533
D Y V A +G+K +C+ + + GL S + AE QAG S P
Sbjct: 20029 DGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDP 20086
Score = 35.0 bits (79), Expect = 0.25
Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 10/127 (7%)
Query: 159 NTTNTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFDSGAL 216
N T T+ +L+ G Y + A N I P + + + + P P D
Sbjct: 18879 NCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 18938
Query: 217 KASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCT--------ISSLQCGTEYLISVLA 268
A+ W + E + + S +S+CT IS L G EY+ V A
Sbjct: 18939 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAA 18998
Query: 269 SNDAGSS 275
N+ G S
Sbjct: 18999 VNEKGRS 19005
Score = 33.1 bits (74), Expect = 0.94
Identities = 39/165 (23%), Positives = 61/165 (36%), Gaps = 25/165 (15%)
Query: 169 SLEAGTLYTIK--------AYAWNANRIPGDDST---CNQRTSPRAPANIQVSFDSGALK 217
S + TL T+K Y + G S C P PA A K
Sbjct: 19468 STDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEK 19527
Query: 218 ASFSWARAE---GA-FNYTVMALSDSSELTCSTT-----FSSCTISSLQCGTEYLISVLA 268
S SW R + GA +Y ++ ++S L + +SC ++ L G EY+ V
Sbjct: 19528 CSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTG 19587
Query: 269 SNDAGSSKSSSAMTLK-----TVACAPGRVTIQEDPPGHLSVAWS 308
N G + ++ +K TV P + I +++ WS
Sbjct: 19588 VNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWS 19632
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 7/72 (9%)
Query: 70 ETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP---PKQAKTVLAAPI----LEVS 122
+T + + TVTGL Y+ I + + G S+ SP P K P LE+
Sbjct: 24009 KTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEIL 24068
Query: 123 SPSSDSILVQWE 134
S S DS+ +QWE
Sbjct: 24069 SISKDSVTLQWE 24080
Score = 32.7 bits (73), Expect = 1.2
Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 17/179 (9%)
Query: 402 ETKAVDGYNMVECNDTTPACTLSALECDT-KYNITVYSFNEVRGSNMSCTPQFITTAPCS 460
E K + Y + N ++ + L DT +Y ITV + + + T + P
Sbjct: 11178 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG 11237
Query: 461 PEIKNVSRDAFSMINVHWRSTNDDA-----TYTVTAQG-EKGLYQCSSTGESCTMRGLP- 513
P N+ + + W+ DD Y V Q K + S+G S T +P
Sbjct: 11238 PI--NILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 11295
Query: 514 ----CGSVFSVTAVAETQAGRSL---PSYSVPLETVPCCPTGLTVTQITQSVINVSWTI 565
C VF V A + G L P+ + + P P VT IT++ VSWT+
Sbjct: 11296 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11354
Score = 32.3 bits (72), Expect = 1.6
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 18/122 (14%)
Query: 28 APEIPTIDQAYSKLSNSITVEWATVPGATS----YLLTAEDGDTVIETTVANS-----PG 78
AP+ P ++ SNS+ V+W S Y L + ++ + V S
Sbjct: 8533 APDKPIVEDV---TSNSMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA 8589
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTV------LAAPILEVSSPSSDSILVQ 132
V GL Y + + +AAG + SPP KT PI V+ SS +I ++
Sbjct: 8590 NVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELE 8649
Query: 133 WE 134
WE
Sbjct: 8650 WE 8651
Score = 31.6 bits (70), Expect = 2.7
Identities = 23/91 (25%), Positives = 41/91 (45%), Gaps = 10/91 (10%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDT-----VIETTVANSPG 78
P P I + NS+TV W+ + Y L D + V++ T+ ++
Sbjct: 20694 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ 20753
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQ 109
VTGL + Y+ + +++AAG+ S P +
Sbjct: 20754 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSE 20784
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 514 CGSVFSVTAVAETQAGRSLPSYS---VPLETVPCCPTGLTVTQITQSVINVSWT 564
C F VTA E + G LP+ + + + VP P +TV +T++ +++SWT
Sbjct: 16729 CSYYFRVTA--ENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWT 16780
Score = 30.8 bits (68), Expect = 4.7
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 26/192 (13%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDTVIETTVANSPGT---- 79
P PT + Y +N++++ W Y + ++ +T++ P
Sbjct: 22469 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22528
Query: 80 -VTGLKAATWYEITIRSISAAG---RSQASPPKQAKTVLAAP-ILEVSSPSSDSILVQWE 134
VTGL Y+ +++AAG S+AS P A+ + AP EV+ + ++ + W
Sbjct: 22529 KVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWS 22588
Query: 135 A-------VYMAIAFSVSIMRANGLGSIWKENTTNTS---LTFTSLEAGTLYTIKAYAWN 184
A + + G G K N T S T T+L G Y + A N
Sbjct: 22589 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKN 22648
Query: 185 ANRI--PGDDST 194
A + G +ST
Sbjct: 22649 AAGVISKGSEST 22660
Score = 30.0 bits (66), Expect = 8.0
Identities = 16/63 (25%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 249 SSCTISSLQCGTEYLISVLASNDAG---SSKSSSAMTLKTVACAPGRVTIQEDPPGHLSV 305
+S I LQ G Y V A N+ G ++++ + + V PG++T+ + +S+
Sbjct: 16718 NSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSL 16777
Query: 306 AWS 308
+W+
Sbjct: 16778 SWT 16780
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 50.1 bits (118), Expect = 7e-06
Identities = 100/423 (23%), Positives = 152/423 (35%), Gaps = 64/423 (15%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEW--------ATVPG-ATSYLLTAEDGDTVIETTVANSP 77
S P+ P + NS T+ W A + G TSY + D E +V
Sbjct: 12300 SEPDPPRKLEVTEMTKNSATLAWLPPLRDGGAKIDGYITSYREEEQPADRWTEYSVVKDL 12359
Query: 78 G-TVTGLKAATWYEITIRSISAAGRS---QASPPKQAKTVLAAPILEVSSPSSDSILVQW 133
VTGLK Y+ + + +A G S +A +AK L P ++ P +I
Sbjct: 12360 SLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPP--KILMPEQITIKAGK 12417
Query: 134 EAVYMAIAFSVSIMRANGLGSIWK----ENTTNTSLTFTSLEAGTLYTIKA--------Y 181
+ A + WK E T++ L ++ ++ IK Y
Sbjct: 12418 KLRIEAHVYGKPHPTCK-----WKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYY 12472
Query: 182 AWNANRIPGDDSTCNQRTSPRAPANIQVSFDSGALKA---SFSWA-----RAEGAFNYTV 233
+ A G D+ + AP Q FD + A S SW NY V
Sbjct: 12473 SLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACSLSWHIPLEDGGSNITNYIV 12532
Query: 234 ----MALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKT---- 285
++ D S T +SC + L G EY+ V A N G S+ ++ +
Sbjct: 12533 EKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLTSPKMVAQFPF 12592
Query: 286 -VACAPGRVTIQEDPPGHLSVAWSSVD------LGDYYVVFVKSDDGLEVHCNTSLTQ-- 336
V P + + + VAW D + Y + + + L V N +L +
Sbjct: 12593 GVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWVKANDTLVRST 12652
Query: 337 ---CNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTA--PCCPSDINPVL-VSSDRVEI 390
C L E G Y ++ NKAG SP Y TA P P V+ V+ V +
Sbjct: 12653 EYPCAGLVE-GLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDPPGKPEVIDVTKSTVSL 12711
Query: 391 VWS 393
+W+
Sbjct: 12712 IWA 12714
Score = 47.8 bits (112), Expect = 4e-05
Identities = 84/426 (19%), Positives = 164/426 (38%), Gaps = 69/426 (16%)
Query: 27 SAPEIPTIDQAYSKLSNSITVEWATVPG-----ATSYLLTAEDGDT------VIETTVAN 75
+ P+ P I + + NSIT+ WA Y+L + + + + ++
Sbjct: 21653 TVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKSTRWVKVISKRPISE 21712
Query: 76 SPGTVTGLKAATWYEITIRSISAAGRSQASPPKQ---AKTVLAAP----ILEVSSPSSDS 128
+ VTGL YE + + +AAG AS + + + P +++V+ S +
Sbjct: 21713 TRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTT 21772
Query: 129 ILVQWEAVYM-----AIAFSVSIMRANGLGSIWKENT---TNTSLTFTSLEAGTLYTIKA 180
+ ++W I + + + +A+ LG K N T T T L+AG Y +
Sbjct: 21773 VSLEWSKPVFDGGMEIIGYIIEMCKAD-LGDWHKVNAEACVKTRYTVTDLQAGEEYKFRV 21831
Query: 181 YAWNAN------RIPGDDSTCNQRTSP--------------RAPANIQVSFD-SGALKAS 219
A N + G ++ T+P RA A+I++ G +
Sbjct: 21832 SAINGAGKGDSCEVTGTIKAVDRLTAPELDIDANFKQTHVVRAGASIRLFIAYQGRPTPT 21891
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W++ + LS +++ + +FS+ T+ + ++ N++GS +
Sbjct: 21892 AVWSKPDSN-------LSLRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGSKSITF 21944
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLG---DYYVV-----FVKSDDGLEVH 329
+ + PG +T ++ G ++ W + +D G +YVV +S +
Sbjct: 21945 TVKVLDTPGPPGPITFKDVTRGSATLMWDAPLLDGGARIHHYVVEKREASRRSWQVISEK 22004
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAGQS---PLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + N L+E G Y+ V N+ G + + T P P ++ V S
Sbjct: 22005 CTRQIFKVNDLAE-GVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKS 22063
Query: 387 RVEIVW 392
+ W
Sbjct: 22064 SAVLAW 22069
Score = 46.2 bits (108), Expect = 1e-04
Identities = 93/435 (21%), Positives = 153/435 (35%), Gaps = 74/435 (17%)
Query: 24 SAKSAPEIPTIDQAYSKLSNSITVEWATVP-----GATSYLLTAEDGDTVIETTVANSP- 77
S AP+ PT+ S NS+TV W T Y L +D + V P
Sbjct: 9818 SVPGAPDKPTVS---SVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRWKRVNRDPI 9874
Query: 78 --------GTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVL------AAPILEVSS 123
VTGL + Y+ + +I+AAG AS P T P +V+
Sbjct: 9875 KAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASLPSDPATARDPIAPPGPPFPKVTD 9934
Query: 124 PSSDSILVQWEAVYMAIAFSVS--IMRANGLG-SIWK----ENTTNTSLTFTSLEAGTLY 176
+ S ++W V+ I+ G W+ + T L T L+ G Y
Sbjct: 9935 WTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDKEVRGTKLVVTGLKEGAFY 9994
Query: 177 TIKAYAWNANRI--PGD------------------DSTCNQRTSPRAPANIQ-VSFDSGA 215
+ A N I PG+ D++ R A I+ +++ SG
Sbjct: 9995 KFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 10054
Query: 216 LKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSS 275
+ +W N L + + + SS I + Q + + S+LA N+AG
Sbjct: 10055 PPPTVTW-------NMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGER 10107
Query: 276 KSSSAMTLKTVACAPGRVTIQEDPPGH-LSVAWSSVD------LGDYYVVFVKSDDGLEV 328
K + + + V G + + + W S + + +Y + +SD
Sbjct: 10108 KKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIEKRESDRRAWT 10167
Query: 329 HCNTSLTQCNFLSE---CGFTYFISVFVYNKAGQSPLGD------IFNYTTAPCCPSDIN 379
++T+ N + G YF + N G P + I T P P D+
Sbjct: 10168 PVTYTVTRQNATVQGLIQGKAYFFRIAAENSIGMGPFVETSEALVIREPITVPERPEDLE 10227
Query: 380 PVLVSSDRVEIVWSP 394
V+ + V + W+P
Sbjct: 10228 VKEVTKNTVTLTWNP 10242
Score = 41.2 bits (95), Expect = 0.003
Identities = 102/484 (21%), Positives = 185/484 (38%), Gaps = 83/484 (17%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV--PGATS---YLLTAEDGDTVIET-----TVANSPG 78
P P+ + + +S+ V WA G T Y+L D + V T T+ +
Sbjct: 18405 PGPPSTPEVSAITKDSMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDLRL 18464
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPK---QAKTVLAAP----ILEVSSPSSDSILV 131
VTGL YE + + +AAG + S P +A L P +V+ S S+ +
Sbjct: 18465 RVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSL 18524
Query: 132 QW-EAVYMAIA----FSVSIMRANGLGSIWKENTTNTSL-----TFTSLEAGTLYTIKAY 181
W + +Y A + V + A W T T L T T L+ T Y +
Sbjct: 18525 AWSKPIYDGGAPVKGYVVEVKEA--AADEWTTCTPPTGLQGKQFTVTKLKENTEYNFRIC 18582
Query: 182 AWNANRIPGDDST------CNQRTSP---------------RAPANIQVSFD-SGALKAS 219
A N+ + G+ +T +R P RA A +++ G +
Sbjct: 18583 AINSEGV-GEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPE 18641
Query: 220 FSWARAEGAFNYTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSS 279
W +AEG L+D +++ +++F+ I ++ ++ N++GS +
Sbjct: 18642 VKWEKAEG-------ILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFV 18694
Query: 280 AMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDLGDYYVVFV--------KSDDGLEVH 329
+ + AP +TI+E ++++W +D G ++ K+ + +
Sbjct: 18695 NVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNN 18754
Query: 330 CNTSLTQCNFLSECGFTYFISVFVYNKAG---QSPLGDIFNYTTAPCCPSDINPVLVSSD 386
C + + L E G +Y+ V N+ G + + + P P + V V+ +
Sbjct: 18755 CTKTTFRIENLQE-GCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 18813
Query: 387 RVEIVW--------SPVRGAEL-YETKAVDGYNMVECNDTTPACTLSALECDTKYNITVY 437
I W S + G + +TK + ++ T A T+S L +Y V
Sbjct: 18814 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEA-TISGLTAGEEYVFRVA 18872
Query: 438 SFNE 441
+ NE
Sbjct: 18873 AVNE 18876
Score = 40.8 bits (94), Expect = 0.005
Identities = 129/605 (21%), Positives = 217/605 (35%), Gaps = 114/605 (18%)
Query: 56 TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAK 111
++Y++ D T ++ TVA + +T LK T Y+ I + + G+S +P
Sbjct: 17941 SNYIVEKRDTTTTTWHMVSATVARTTIKITKLKTGTEYQFRIFAENRYGKS--APLDSKA 17998
Query: 112 TVLAAPILE--------VSSPSSDSILVQW-----EAVYMAIAFSVSIMRANGLGSIW-K 157
++ P E V+S S D +LVQW + I + + N + +W K
Sbjct: 17999 VIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSI--LWVK 18056
Query: 158 ENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFD 212
N T +T T L+ G Y K A N I P S C P P +
Sbjct: 18057 LNKTPIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVSECFVARDPCDPPGRPEAIV 18116
Query: 213 SGALKASFSWARA--EGAFNYT-----VMALSDSSELTCSTT---FSSCTISSLQCGTEY 262
+ W + +G T L D + S T + T+S L Y
Sbjct: 18117 ITRNNVTLKWKKPAYDGGSKITGYIVEKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRY 18176
Query: 263 LISVLASNDAGS----SKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYYVV 318
V+A N AG+ S SS A+T + AP P + V V G+ +V+
Sbjct: 18177 EFRVIARNAAGNFSEPSDSSGAITARDEIDAPNASL----DPKYKDVI--VVHAGETFVL 18230
Query: 319 -----------FVKSDDGLEVH------------CNTSLTQCNFLSECGFTYFISVFVYN 355
V S DG E+ T+L + + G Y + + N
Sbjct: 18231 EADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQKTTLVVKDCIRTDGGQYILK--LSN 18288
Query: 356 KAGQSPLGDIFNYTTAPCCP-SDINPVLVSSDRVEIVWSPVRGAELYETKAVDGYNMVEC 414
G + P P + V++++ + W+P L + A + ++E
Sbjct: 18289 VGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAWNP----PLQDGGANISHYIIEK 18344
Query: 415 NDT-----TPACT--------LSALECDTKYNITVYSFNEV-------RGSNMSCTPQFI 454
+T T T ++ L +Y V + N+ G +C P
Sbjct: 18345 RETSRLSWTQVSTEVQALNYKVTKLLPGNEYIFRVMAVNKYGIGEPLESGPVTACNPYKP 18404
Query: 455 TTAPCSPEIKNVSRDAFSMINVHWRSTNDDAT----YTVTAQGEKGLYQCSSTGESCT-- 508
P +PE+ +++D SM+ R +D T Y + + ++G+ ++ T
Sbjct: 18405 PGPPSTPEVSAITKD--SMVVTWARPVDDGGTEIEGYILEKRDKEGVRWTKCNKKTLTDL 18462
Query: 509 ---MRGLPCGSVFSVTAVAETQAGRSLPSYSVPLETV------PCCPTGLTVTQITQSVI 559
+ GL G + AE AG PS P P+ VT ++S +
Sbjct: 18463 RLRVTGLTEGHSYEFRVAAENAAGVGEPSEPSVFYRACDALYPPGPPSNPKVTDTSRSSV 18522
Query: 560 NVSWT 564
+++W+
Sbjct: 18523 SLAWS 18527
Score = 39.7 bits (91), Expect = 0.010
Identities = 56/242 (23%), Positives = 94/242 (38%), Gaps = 27/242 (11%)
Query: 68 VIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP-PKQAKTVLAAPILEVSSPSS 126
+I+TT + S V + + TI + + +G+ A+ K T P ++V S
Sbjct: 22995 IIDTTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSR 23054
Query: 127 DSILVQWEAVYM---AIAFSVSIMRANGLGSIWKENTTNTSLT---FTSLEAGTLYTIKA 180
DS+ + WE + A + + + +K TT S T + L GT+Y +
Sbjct: 23055 DSVTITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRV 23114
Query: 181 YAWNANRIPGDDSTCNQRTS------PRAPANIQVSFDSGALKASFSWAR-----AEGAF 229
N I G C + P PA ++V D + +W +
Sbjct: 23115 LPEN---IYGIGEPCETSDAVLVSEVPLVPAKLEV-VDVTKSTVTLAWEKPLYDGGSRLT 23170
Query: 230 NYTVMALSDSSE-----LTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLK 284
Y + A +E +T T T++SL G +YL + A N+ G S+ +T
Sbjct: 23171 GYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAV 23230
Query: 285 TV 286
TV
Sbjct: 23231 TV 23232
Score = 38.1 bits (87), Expect = 0.029
Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 18/123 (14%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSA---MTLKTVACAPGRVTIQEDPPGHLSVAWS- 308
++ L G EY A N AG SK+S A + + APGR + + +S+ WS
Sbjct: 22405 VTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSA 22464
Query: 309 -SVDLGDYYVVFV-------KSDDGLEVHCNTSLTQCNF-----LSECGFTYFISVFVYN 355
+ D G V ++ + DG + CN ++ NF LSE G TY V N
Sbjct: 22465 PAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSE-GDTYEFRVLAKN 22523
Query: 356 KAG 358
AG
Sbjct: 22524 AAG 22526
Score = 37.7 bits (86), Expect = 0.038
Identities = 86/369 (23%), Positives = 131/369 (35%), Gaps = 69/369 (18%)
Query: 253 ISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGH---------- 302
+S L G Y V A N AG K S + C P DPPG
Sbjct: 19151 VSGLDEGLMYEYRVYAENIAGIGKCSKS-------CEPVPARDPCDPPGQPEVTNITRKS 19203
Query: 303 LSVAWSS------VDLGDYYVVFVKSDDGLEVHCNTSLTQCNFLSECGFT----YFISVF 352
+S+ WS + Y V + DG + CN + Q + T Y VF
Sbjct: 19204 VSLKWSKPHYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVF 19263
Query: 353 VYNKAGQSPLGDIFNYTTAPCCPSDINP------------VLVSSDRVEIVWSPVRGAEL 400
N A + + T D+ P ++V + V + + + G L
Sbjct: 19264 ARNAADS--VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPL 19321
Query: 401 YETK-AVDGYNMVECNDTTPACT-----LSALEC---DT-KYNITVYSFNEVRGSNMSCT 450
A DG + E T T L+ +C DT +Y +T+ + R ++C
Sbjct: 19322 PVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCK 19381
Query: 451 PQFITTAPCSP-EIKNVSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKGLYQCSSTG 504
P P EI ++ + S+ W +D Y V + L G
Sbjct: 19382 VLDKPGPPAGPLEINGLTAEKCSL---SWGRPQEDGGADIDYYIVEKRETSHLAWTICEG 19438
Query: 505 E----SCTMRGLPCGS--VFSVTAVAETQAGRSLPSYSVPLE---TVPCCPTGLTVTQIT 555
E SC + L G+ +F VT V + G L S ++ TVP PT L +T +T
Sbjct: 19439 ELQMTSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVT 19498
Query: 556 QSVINVSWT 564
+ + + W+
Sbjct: 19499 KESMTLCWS 19507
Score = 36.6 bits (83), Expect = 0.085
Identities = 83/390 (21%), Positives = 134/390 (34%), Gaps = 58/390 (14%)
Query: 56 TSYLLTAEDGDTVIETTVANSPGT-----VTGLKAATWYEITIRSISAAG---RSQASPP 107
T YLL + V T V P TGL+ T YE + +I+ AG S AS
Sbjct: 13023 TGYLLEKRETQAVNWTKVNRKPIIERTLKATGLQEGTEYEFRVTAINKAGPGKPSDASKA 13082
Query: 108 KQAKTVLAAP----ILEVSSPSSDSILVQW-----EAVYMAIAFSVSIMRA---NGLGSI 155
A+ P +V + S+ + W + I + V + RA N +
Sbjct: 13083 AYARDPQYPPGPPAFPKVYDTTRSSVSLSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCN 13142
Query: 156 WKENTTNTSLTFTSLEAGTLYTIKAYAWNA-----------NRIPGD---------DSTC 195
+N T T L T Y + YA N P D D+
Sbjct: 13143 LPQNLQKTRFEVTGLMEDTQYQFRVYAVNKIGYSDPSDVPDKHYPKDILIPPEGELDADL 13202
Query: 196 NQRTSPRAPANIQVSFD-SGALKASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCTIS 254
+ RA +++ G +W++ + S++ TF C
Sbjct: 13203 RKTLILRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDF---DTFLRCENV 13259
Query: 255 SLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSS--VDL 312
+ +Y++++ N G + + + + P VT++E V W +D
Sbjct: 13260 NKYDAGKYILTL--ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDG 13317
Query: 313 GDYYVVF-VKSDDGLEVHCNTSLTQCNFLS------ECGFTYFISVFVYNKAGQSPLGDI 365
G + + V+ D +T T+C+ S E G +YF VF N+ G G+
Sbjct: 13318 GSPIINYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGET 13377
Query: 366 FNYTTAPCCPS---DINPVLVSSDRVEIVW 392
+ A P D+ VS I W
Sbjct: 13378 RDAVKASQTPGPVVDLKVRSVSKSSCSIGW 13407
Score = 36.6 bits (83), Expect = 0.085
Identities = 104/471 (22%), Positives = 156/471 (33%), Gaps = 97/471 (20%)
Query: 168 TSLEAGTLYTIKAYAWNANRIPGDDSTCNQ---RTSPRAPANIQVSFDSGALKASFSWAR 224
T L G Y + A N I T +P P ++ + D S +W +
Sbjct: 14432 TGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNI-MDITKSTVSLAWPK 14490
Query: 225 A--EGAFNYTVMALS----DSSELTCSTTFSS--CTISSLQCGTEYLISVLASNDAGSS- 275
+G T + S + T TT C + +L G EY V+A N AG S
Sbjct: 14491 PKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSA 14550
Query: 276 -KSSSAMTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGDYY--VVFVKSDDGLEVHCNT 332
+ S + +K P +DL Y +V K+ D ++V
Sbjct: 14551 PRESRPVIVKEQTMLP------------------ELDLRGIYQKLVIAKAGDNIKVEIPV 14592
Query: 333 ------------------SLTQCNFLSECGFTYF-ISVFVYNKAGQSPL---------GD 364
+ NF + T I+ V + +G PL GD
Sbjct: 14593 LGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGD 14652
Query: 365 IFNYTTAPCCPSDINPVL---VSSDRVEIVWSPVRGAE-------LYETKAVDGYNMVEC 414
+ P+ VSSD V W P + E + D VE
Sbjct: 14653 VITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVEMRQTDSTTWVEL 14712
Query: 415 NDTTPACTLSALECDT--KYNITVYSFNEVR---GSNMSCT----PQFITTAPCSPEIKN 465
T T A T +Y V + N G +C P + P +P++
Sbjct: 14713 ATTVIRTTYKATRLTTGLEYQFRVKAQNRYGVGPGITSACIVANYPFKVPGPPGTPQVTA 14772
Query: 466 VSRDAFSMINVHWRSTNDDAT-----YTVTAQGEKG-LYQCSST----GESCTMRGLPCG 515
V++D+ + + W D Y V + G L+Q S G GL G
Sbjct: 14773 VTKDSMT---ISWHEPLSDGGSPILGYHVERKERNGILWQTVSKALVPGNIFKSSGLTDG 14829
Query: 516 SVFSVTAVAETQAGRSLPSY-SVPLETV-PCCPTGLTV-TQITQSVINVSW 563
+ +AE AG+S PS S P+ + P P G V IT+ + + W
Sbjct: 14830 IAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPVPLNITRHTVTLKW 14880
Score = 36.2 bits (82), Expect = 0.11
Identities = 68/279 (24%), Positives = 101/279 (36%), Gaps = 42/279 (15%)
Query: 42 SNSITVEW--ATVPGA---TSYLLTAEDGDT----VIETTVANSPGTVTGLKAATWYEIT 92
+ SIT+ W G T+Y++ D T V+ TVA + VT LK T Y+
Sbjct: 16840 AESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFR 16899
Query: 93 IRSISAAGRSQASPPKQAKTVLAAPILEVSSP--------SSDSILVQWEAVY-----MA 139
I + + G+S A + V P E P S DS+++QW
Sbjct: 16900 IFAENRYGQSFAL--ESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPV 16957
Query: 140 IAFSVSIMRANGLGSIW-KENTT---NTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDS 193
I + + N + +W K N T +T +LE G Y + YA N + +S
Sbjct: 16958 IGYHLERKERNSI--LWTKVNKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNS 17015
Query: 194 TCNQRTSPRAPANIQVSFDSGALKASFSWARA--EGAFNYT-----VMALSDSSELTCST 246
C P P + + W + +G T L D + S
Sbjct: 17016 ECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASF 17075
Query: 247 T---FSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMT 282
T + T+S L Y V+A N AG+ S T
Sbjct: 17076 TNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDST 17114
Score = 35.4 bits (80), Expect = 0.19
Identities = 105/478 (21%), Positives = 169/478 (35%), Gaps = 71/478 (14%)
Query: 119 LEVSSPSSDSILVQWEAVYMAIAFSVS---IMRANGLGSIW----KENTTNTSLTFTSLE 171
LE++S + +S+ + W +S I R W K+ + + T L
Sbjct: 19492 LEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKKPVYDLRVKSTGLR 19551
Query: 172 AGTLYTIKAYAWNAN--RIPGDDSTCNQRTSP---RAPANIQVSFDSGALKASFSWARA- 225
G Y + YA NA +P + S + P +P + DSG + +W +
Sbjct: 19552 EGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPL 19611
Query: 226 --EGA--FNYTVMALSDSSELTCSTTFSSC-----TISSLQCGTEYLISVLASNDAGSSK 276
GA YTV S + T+ S TIS L G EY+ V + N G+S
Sbjct: 19612 FDGGAPITGYTV-EYKKSDDTDWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASD 19670
Query: 277 SSSA----------------------MTLKTVACAPGRVTIQEDPPGHLSVAWSSVDLGD 314
S + TL A A +T+ +V WS D
Sbjct: 19671 PSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDL 19730
Query: 315 YYVVFVKSDDGLEVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTAPCC 374
+V + D TSLT N Y ++ + N + L + P
Sbjct: 19731 RTRAYVDTTDS-----RTSLTIENANRNDSGKYTLT--IQNVLSAASLTLVVKVLDTPGP 19783
Query: 375 PSDINPVLVSSDRVEIVW--------SPVRGAELYETKA-VDGYNMVECNDTTPACTLSA 425
P++I V+ + + W +PV+ + + +A + V N + ++
Sbjct: 19784 PTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTNNCNRLSYKVTN 19843
Query: 426 LECDTKYNITVYSFNEVRGSNMSCTPQ--FITTAPCSPEIKNVSRDAFSMINVHWRSTND 483
L+ Y V NE + T + IT P PE V+ + +++ W
Sbjct: 19844 LQEGAIYYFRVSGENEFGVGIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEH 19903
Query: 484 D-----ATYTVTA--QGEKGLYQCS-STGESCTMRGLPCGSVFSVTAVAETQAGRSLP 533
D Y V A +G+K +C+ + + GL S + AE QAG S P
Sbjct: 19904 DGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLRENSEYFFRVFAENQAGLSDP 19961
Score = 35.0 bits (79), Expect = 0.25
Identities = 31/127 (24%), Positives = 47/127 (37%), Gaps = 10/127 (7%)
Query: 159 NTTNTSLTFTSLEAGTLYTIKAYAWNANRI--PGDDSTCNQRTSPRAPANIQVSFDSGAL 216
N T T+ +L+ G Y + A N I P + + + + P P D
Sbjct: 18754 NCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPPLPPGRVTLVDVTRN 18813
Query: 217 KASFSWARAEGAFNYTVMALSDSSELTCSTTFSSCT--------ISSLQCGTEYLISVLA 268
A+ W + E + + S +S+CT IS L G EY+ V A
Sbjct: 18814 TATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTCTQVKTLEATISGLTAGEEYVFRVAA 18873
Query: 269 SNDAGSS 275
N+ G S
Sbjct: 18874 VNEKGRS 18880
Score = 33.1 bits (74), Expect = 0.94
Identities = 39/165 (23%), Positives = 61/165 (36%), Gaps = 25/165 (15%)
Query: 169 SLEAGTLYTIK--------AYAWNANRIPGDDST---CNQRTSPRAPANIQVSFDSGALK 217
S + TL T+K Y + G S C P PA A K
Sbjct: 19343 STDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEK 19402
Query: 218 ASFSWARAE---GA-FNYTVMALSDSSELTCSTT-----FSSCTISSLQCGTEYLISVLA 268
S SW R + GA +Y ++ ++S L + +SC ++ L G EY+ V
Sbjct: 19403 CSLSWGRPQEDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTG 19462
Query: 269 SNDAGSSKSSSAMTLK-----TVACAPGRVTIQEDPPGHLSVAWS 308
N G + ++ +K TV P + I +++ WS
Sbjct: 19463 VNKYGVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWS 19507
Score = 33.1 bits (74), Expect = 0.94
Identities = 24/72 (33%), Positives = 34/72 (47%), Gaps = 7/72 (9%)
Query: 70 ETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASP---PKQAKTVLAAPI----LEVS 122
+T + + TVTGL Y+ I + + G S+ SP P K P LE+
Sbjct: 23884 KTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEIL 23943
Query: 123 SPSSDSILVQWE 134
S S DS+ +QWE
Sbjct: 23944 SISKDSVTLQWE 23955
Score = 32.7 bits (73), Expect = 1.2
Identities = 45/179 (25%), Positives = 69/179 (38%), Gaps = 17/179 (9%)
Query: 402 ETKAVDGYNMVECNDTTPACTLSALECDT-KYNITVYSFNEVRGSNMSCTPQFITTAPCS 460
E K + Y + N ++ + L DT +Y ITV + + + T + P
Sbjct: 11053 EIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTG 11112
Query: 461 PEIKNVSRDAFSMINVHWRSTNDDA-----TYTVTAQG-EKGLYQCSSTGESCTMRGLP- 513
P N+ + + W+ DD Y V Q K + S+G S T +P
Sbjct: 11113 PI--NILDVTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPH 11170
Query: 514 ----CGSVFSVTAVAETQAGRSL---PSYSVPLETVPCCPTGLTVTQITQSVINVSWTI 565
C VF V A + G L P+ + + P P VT IT++ VSWT+
Sbjct: 11171 LQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTL 11229
Score = 32.3 bits (72), Expect = 1.6
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 18/122 (14%)
Query: 28 APEIPTIDQAYSKLSNSITVEWATVPGATS----YLLTAEDGDTVIETTVANS-----PG 78
AP+ P ++ SNS+ V+W S Y L + ++ + V S
Sbjct: 8408 APDKPIVEDV---TSNSMLVKWNEPKDNGSPILGYWLEKREVNSTHWSRVNKSLLNALKA 8464
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTV------LAAPILEVSSPSSDSILVQ 132
V GL Y + + +AAG + SPP KT PI V+ SS +I ++
Sbjct: 8465 NVDGLLEGLTYVFRVCAENAAGPGKFSPPSDPKTAHDPISPPGPPIPRVTDTSSTTIELE 8524
Query: 133 WE 134
WE
Sbjct: 8525 WE 8526
Score = 31.6 bits (70), Expect = 2.7
Identities = 23/91 (25%), Positives = 41/91 (45%), Gaps = 10/91 (10%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDT-----VIETTVANSPG 78
P P I + NS+TV W+ + Y L D + V++ T+ ++
Sbjct: 20569 PGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFKVLKETIRDTRQ 20628
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQ 109
VTGL + Y+ + +++AAG+ S P +
Sbjct: 20629 KVTGLTENSDYQYRVCAVNAAGQGPFSEPSE 20659
Score = 31.2 bits (69), Expect = 3.6
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 5/54 (9%)
Query: 514 CGSVFSVTAVAETQAGRSLPSYS---VPLETVPCCPTGLTVTQITQSVINVSWT 564
C F VTA E + G LP+ + + + VP P +TV +T++ +++SWT
Sbjct: 16604 CSYYFRVTA--ENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWT 16655
Score = 30.8 bits (68), Expect = 4.7
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 26/192 (13%)
Query: 29 PEIPTIDQAYSKLSNSITVEWATV-----PGATSYLLTAEDGDTVIETTVANSPGT---- 79
P PT + Y +N++++ W Y + ++ +T++ P
Sbjct: 22344 PSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNY 22403
Query: 80 -VTGLKAATWYEITIRSISAAG---RSQASPPKQAKTVLAAP-ILEVSSPSSDSILVQWE 134
VTGL Y+ +++AAG S+AS P A+ + AP EV+ + ++ + W
Sbjct: 22404 KVTGLVEGLEYQFRTYALNAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWS 22463
Query: 135 A-------VYMAIAFSVSIMRANGLGSIWKENTTNTS---LTFTSLEAGTLYTIKAYAWN 184
A + + G G K N T S T T+L G Y + A N
Sbjct: 22464 APAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYTIVSDNFFTVTALSEGDTYEFRVLAKN 22523
Query: 185 ANRI--PGDDST 194
A + G +ST
Sbjct: 22524 AAGVISKGSEST 22535
Score = 30.0 bits (66), Expect = 8.0
Identities = 16/63 (25%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 249 SSCTISSLQCGTEYLISVLASNDAG---SSKSSSAMTLKTVACAPGRVTIQEDPPGHLSV 305
+S I LQ G Y V A N+ G ++++ + + V PG++T+ + +S+
Sbjct: 16593 NSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSL 16652
Query: 306 AWS 308
+W+
Sbjct: 16653 SWT 16655
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 49.3 bits (116), Expect = 1e-05
Identities = 141/716 (19%), Positives = 253/716 (35%), Gaps = 129/716 (18%)
Query: 7 TCLPLIGFILICLKMVASAKSAPEIPTIDQAYSKLSNSITVEWATVPG------ATSYLL 60
TC+ + +I + K+ P+ P + S+T+ W + Y
Sbjct: 297 TCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRA 356
Query: 61 TAEDGDTVIETTVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-- 118
+G VA + ++ GL + Y + ++++ GR S +A+T AP
Sbjct: 357 AGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSP 416
Query: 119 ---LEVSSPSSDSILVQWEAVY--------MAIAFSVSIMRANGLGSIWKENTTNTSL-- 165
++ S+ ++LVQWE + ++ R + W ++ T+ L
Sbjct: 417 PRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRP---PNAWHKHNTDAGLLT 473
Query: 166 TFTSLEAGTLYTIKAYAWNANRIPGDDSTCNQRTS---PRAPANIQVSFDSGA-LKASFS 221
T SL G Y+++ A+ A T +T P PA+ Q +S ++ S+
Sbjct: 474 TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWL 533
Query: 222 WARAEGAFNY-TVMALSDSSELTCSTTF---SSCTISSLQCGTEYLISVLASNDAG---- 273
E Y V ++ + TF SS T+ L+ T Y + A +D G
Sbjct: 534 LPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVF 593
Query: 274 --------SSKSSSAMTLKTVACAPGRVTIQED---PPG--------HLSVAWSSVDLGD 314
+ + SA K + + G T++ PP SVA+ +VD D
Sbjct: 594 TPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGED 653
Query: 315 --YYVVFVKSDDGL-EVHCNTSLTQCNFLSECGFTYFISVFVYNKAGQSPLGDIFNYTTA 371
+VV DG+ H + L +E Y + V + G P T
Sbjct: 654 RGRHVV-----DGISREHSSWDLVGLEKWTE----YRVWVRAHTDVGPGPESSPVLVRTD 704
Query: 372 PCCPS------DINPVLVSSDRVEIVW---------SPVRGAELYETKAVDG-------- 408
PS ++ P ++S V + W +RG ++ + +G
Sbjct: 705 EDVPSGPPRKVEVEP--LNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPII 762
Query: 409 ---------YNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPC 459
+ E D T+S L +T Y++TV ++ +G P+ +TT
Sbjct: 763 QDVMLAEAQWRPEESEDY--ETTISGLTPETTYSVTVAAYT-TKGDGARSKPKIVTTTGA 819
Query: 460 SP--EIKNVSRDAFSMINVHWRSTND--------DATYTVTAQGEKGLYQCSSTGESCTM 509
P +S A + + W + Y + + T+
Sbjct: 820 VPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTV 879
Query: 510 RGLPCGSVFSVTAVAETQAGRSLPSYSVPLETVPCCPTG----LTVTQITQSVINVSWTI 565
GL G+ + A+ +AG + + T P+G L VT +T S ++W
Sbjct: 880 TGLHKGTTYIFRLAAKNRAGLG-EEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDP 938
Query: 566 GRVAQTHVAVLESHTGQSKCHTHQNHCLLGCITCGINYTVTLKAISATGLTADCSY 621
+A+ + ++ ++ Q L IT +T+ TGL D +Y
Sbjct: 939 PVLAERNGRIISYTVVFRDINSQQE---LQNITTDTRFTL-------TGLKPDTTY 984
Score = 46.6 bits (109), Expect = 8e-05
Identities = 56/231 (24%), Positives = 94/231 (40%), Gaps = 28/231 (12%)
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKT---VLAAPILEVSSPSSDSILVQW-- 133
T++GL T Y +T+ + + G S PK T V P + +S+ + ++ L+QW
Sbjct: 783 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHP 842
Query: 134 --EAVYMAIAFSVSIMRANGLGSIWKENT-----TNTSLTFTSLEAGTLYTIKAYAWNAN 186
E + + + RA+ + NT + T T L GT Y + A N
Sbjct: 843 PKELPGELLGYRLQYCRADEA----RPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRA 898
Query: 187 RIPGDDSTCNQRTSPRAPANIQVSFDSGALKAS---FSW------ARAEGAFNYTVM--A 235
+ G++ RT P+ + L S +W R +YTV+
Sbjct: 899 GL-GEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRD 957
Query: 236 LSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTV 286
++ EL TT + T++ L+ T Y I V A GS S ++ +T+
Sbjct: 958 INSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTM 1008
Score = 37.4 bits (85), Expect = 0.050
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 13/109 (11%)
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTV----LAAPILEVSSPSSDSILVQWE 134
T+TGLK T Y+I +R+ ++ G SP Q++T+ + A V++ S+L+ WE
Sbjct: 974 TLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWE 1033
Query: 135 -------AVYMAIAFSVSIMRANG--LGSIWKENTTNTSLTFTSLEAGT 174
AV I ++ + +G + + + NT +F + G+
Sbjct: 1034 VPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGS 1082
Score = 36.2 bits (82), Expect = 0.11
Identities = 46/201 (22%), Positives = 81/201 (40%), Gaps = 22/201 (10%)
Query: 20 KMVASAKSAPEIPTIDQAYSKLSNSITVEW---ATVPGAT-----SYLLTAEDGDTVIET 71
K+V + + P PT+ + + + N+ ++W +PG Y E I+
Sbjct: 812 KIVTTTGAVPGRPTMMISTTAM-NTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDF 870
Query: 72 TVANSPGTVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-----LEVSSPSS 126
+ TVTGL T Y + + + AG + K+ +T P L V+ ++
Sbjct: 871 GKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFE-KEIRTPEDLPSGFPQNLHVTGLTT 929
Query: 127 DSILVQWEAVYMA------IAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKA 180
+ + W+ +A I+++V N + + TT+T T T L+ T Y IK
Sbjct: 930 STTELAWDPPVLAERNGRIISYTVVFRDINSQQEL-QNITTDTRFTLTGLKPDTTYDIKV 988
Query: 181 YAWNANRIPGDDSTCNQRTSP 201
AW + + RT P
Sbjct: 989 RAWTSKGSGPLSPSIQSRTMP 1009
Score = 31.2 bits (69), Expect = 3.6
Identities = 55/243 (22%), Positives = 90/243 (37%), Gaps = 49/243 (20%)
Query: 252 TISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACAPGRVT------------IQEDP 299
TIS L T Y ++V A G S + T PGR T +Q P
Sbjct: 783 TISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHP 842
Query: 300 PGHLSVAWSSVDLGDYYVVFVKSDDGLEVHCNTSLTQCNFL---SECGFTYFISVFVYNK 356
P L +L Y + + ++D+ + +F G TY + N+
Sbjct: 843 PKEL-----PGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 897
Query: 357 AGQSPLGDIF--NYTTAPCCPS----DINPVLVSSDRVEIVWSPVRGAE--------LYE 402
AG LG+ F T PS +++ +++ E+ W P AE
Sbjct: 898 AG---LGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVV 954
Query: 403 TKAVDGYNMVECNDTTPACTLSALECDTKYNITVYSFNEVRGSNMSCTPQFITTAPCSPE 462
+ ++ ++ T TL+ L+ DT Y+I V ++ +GS P SP
Sbjct: 955 FRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTS-KGS-----------GPLSPS 1002
Query: 463 IKN 465
I++
Sbjct: 1003 IQS 1005
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 48.5 bits (114), Expect = 2e-05
Identities = 64/255 (25%), Positives = 105/255 (41%), Gaps = 39/255 (15%)
Query: 347 YFISVFVYNKAGQSPLGDIFNYTTAPCCPS----DINPVLVSSDRVEIVWSP-------- 394
Y I ++ +NK G+S +T P D+ V+S +++ W
Sbjct: 1018 YSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWKAPKKELQNG 1077
Query: 395 -VRGAELYETKAVDG----YNMVECNDT--TPACTLSALECDTKYNITVYSFNEVRGSNM 447
+RG ++ + G Y++VE T + TL L+ +Y + V +FN G+
Sbjct: 1078 VIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRA-GTGP 1136
Query: 448 SCTPQFITTAPCSPEIKNVSRDAFSMIN----VHW----RSTNDDAT-------YTVTAQ 492
S + TT P + A S+ + + W RST + +++
Sbjct: 1137 SSSEINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVD 1196
Query: 493 GEKGLYQ-CSSTGESCTMRGLPCGSVFSVTAVAETQAG---RSLPSYSVPLETVPCCPTG 548
GE G Q ++T E +RG+ + +SV +A TQAG RS Y E VP P G
Sbjct: 1197 GEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAG 1256
Query: 549 LTVTQITQSVINVSW 563
+ + S + VSW
Sbjct: 1257 IKAVPSSASSVVVSW 1271
Score = 40.0 bits (92), Expect = 0.008
Identities = 53/244 (21%), Positives = 91/244 (37%), Gaps = 32/244 (13%)
Query: 79 TVTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAPI-----LEVSSPSSDSILVQW 133
T+ LK Y + +++ + AG +S A T+ P + S +SD ++ W
Sbjct: 1112 TLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDVAVISW 1171
Query: 134 EAV-----------YMAIAFSVSIMRANGLGSIWKENTTNTSLTFTSLEAGTLYTIKAYA 182
Y I +S+ + G + TT + +E T Y+++ A
Sbjct: 1172 SEPPRSTLNGVLKGYRVIFWSLYV--DGEWGEMQNITTTRERVELRGMEKFTNYSVQVLA 1229
Query: 183 WNANRIPGDDSTCNQRTS---PRAPANIQVSFDSGALKASFSW---ARAEGAFN-YTVMA 235
+ S +T P PA I+ + S A SW + G YT+
Sbjct: 1230 YTQAGDGVRSSVLYIQTKEDVPGPPAGIK-AVPSSASSVVVSWLPPTKPNGVIRKYTIFC 1288
Query: 236 LSDSSELTCSTTFSSCT------ISSLQCGTEYLISVLASNDAGSSKSSSAMTLKTVACA 289
S S + + + I+ L G +YL+ V A AG SS +T++ A
Sbjct: 1289 SSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKA 1348
Query: 290 PGRV 293
P ++
Sbjct: 1349 PAKI 1352
Score = 35.0 bits (79), Expect = 0.25
Identities = 59/246 (23%), Positives = 94/246 (38%), Gaps = 36/246 (14%)
Query: 80 VTGLKAATWYEITIRSISAAGRSQASPPKQAKTVLAAP-----ILEVSSPSSDSILVQWE 134
+ L A+ Y I + S + GRS+ S T AAP + + +S SI V W+
Sbjct: 1009 IVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTWK 1068
Query: 135 AVY----------MAIAFSVSIMRANGLGSIWKENTTNTSLTFT--SLEAGTLYTIKAYA 182
A I + + +NG SI + T S +T +L+ Y + A
Sbjct: 1069 APKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQA 1128
Query: 183 WNANRIPGDDSTCNQRT----SPRAPANIQ-VSFDSGALKASFSWARAEGAF------NY 231
+N S N T + P N++ +S S A SW+ + Y
Sbjct: 1129 FNRAGTGPSSSEINATTLEDVPSQPPENVRALSITSDV--AVISWSEPPRSTLNGVLKGY 1186
Query: 232 TVMALS-----DSSEL-TCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKT 285
V+ S + E+ +TT + ++ T Y + VLA AG SS + ++T
Sbjct: 1187 RVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQT 1246
Query: 286 VACAPG 291
PG
Sbjct: 1247 KEDVPG 1252
Score = 33.5 bits (75), Expect = 0.72
Identities = 17/55 (30%), Positives = 29/55 (52%)
Query: 231 YTVMALSDSSELTCSTTFSSCTISSLQCGTEYLISVLASNDAGSSKSSSAMTLKT 285
Y+V + ++ S++ S + SL+CGT Y + + A N GS + S + KT
Sbjct: 1480 YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEIIEAKT 1534
Score = 30.8 bits (68), Expect = 4.7
Identities = 15/29 (51%), Positives = 21/29 (72%), Gaps = 2/29 (6%)
Query: 74 ANSPGTV--TGLKAATWYEITIRSISAAG 100
ANS G V T L+ ATWYE+ +R+ ++AG
Sbjct: 1590 ANSSGEVFLTELREATWYELRMRACNSAG 1618
Score = 30.0 bits (66), Expect = 8.0
Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 4/52 (7%)
Query: 516 SVFSVTAVAETQAGRSLPSYSVPLETVPCCPTG----LTVTQITQSVINVSW 563
SV+S+ + + GRS PS + + T P G +T+ +T I V+W
Sbjct: 1016 SVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQSIQVTW 1067
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.129 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,912,979
Number of Sequences: 37866
Number of extensions: 1199681
Number of successful extensions: 4043
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 2998
Number of HSP's gapped (non-prelim): 862
length of query: 733
length of database: 18,247,518
effective HSP length: 110
effective length of query: 623
effective length of database: 14,082,258
effective search space: 8773246734
effective search space used: 8773246734
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.