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Search of human proteins with 222136641
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222136641 NIMA-related kinase 9 [Homo sapiens]
(979 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 1999 0.0
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 405 e-113
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 232 1e-60
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 216 1e-55
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 209 1e-53
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 201 4e-51
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 201 4e-51
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 201 4e-51
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 189 8e-48
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 171 4e-42
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 167 6e-41
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 167 6e-41
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 163 8e-40
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 163 8e-40
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 163 8e-40
gi|126032348 hect domain and RLD 2 [Homo sapiens] 138 2e-32
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 136 1e-31
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 134 5e-31
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 134 5e-31
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 134 5e-31
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 134 5e-31
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 134 5e-31
gi|93004081 polo-like kinase 2 [Homo sapiens] 133 9e-31
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 133 9e-31
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 133 9e-31
gi|121114283 polo-like kinase 4 [Homo sapiens] 132 1e-30
gi|21359873 polo-like kinase 1 [Homo sapiens] 132 2e-30
gi|29826329 p21-activated kinase 7 [Homo sapiens] 132 2e-30
gi|24308191 p21-activated kinase 7 [Homo sapiens] 132 2e-30
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 132 2e-30
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 1999 bits (5180), Expect = 0.0
Identities = 979/979 (100%), Positives = 979/979 (100%)
Query: 1 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR 60
MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR
Sbjct: 1 MSVLGEYERHCDSINSDFGSESGGCGDSSPGPSASQGPRAGGGAAEQEELHYIPIRVLGR 60
Query: 61 GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD 120
GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD
Sbjct: 61 GAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD 120
Query: 121 NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL 180
NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
Sbjct: 121 NTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL 180
Query: 181 NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV 240
NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV
Sbjct: 181 NIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCV 240
Query: 241 IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD 300
IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD
Sbjct: 241 IFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTAD 300
Query: 301 ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ 360
ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ
Sbjct: 301 ELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQ 360
Query: 361 KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV 420
KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV
Sbjct: 361 KLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV 420
Query: 421 EKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN 480
EKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN
Sbjct: 421 EKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSN 480
Query: 481 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG 540
PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG
Sbjct: 481 PVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCG 540
Query: 541 CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR 600
CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR
Sbjct: 541 CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR 600
Query: 601 TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDE 660
TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDE
Sbjct: 601 TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDE 660
Query: 661 FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT 720
FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT
Sbjct: 661 FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHT 720
Query: 721 ILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRG 780
ILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRG
Sbjct: 721 ILIVEKVLNSKTIRSNSSGLSIGTVFQSSSPGGGGGGGGGEEEDSQQESETPDPSGGFRG 780
Query: 781 TMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEK 840
TMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEK
Sbjct: 781 TMEADRGMEGLISPTEAMGNSNGASSSCPGWLRKELENAEFIPMPDSPSPLSAAFSESEK 840
Query: 841 DTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVE 900
DTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVE
Sbjct: 841 DTLPYEELQGLKVASEAPLEHKPQVEASSPRLNPAVTCAGKGTPLTPPACACSSLQVEVE 900
Query: 901 RLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKP 960
RLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKP
Sbjct: 901 RLQGLVLKCLAEQQKLQQENLQIFTQLQKLNKKLEGGQQVGMHSKGTQTAKEEMEMDPKP 960
Query: 961 DLDSDSWCLLGTDSCRPSL 979
DLDSDSWCLLGTDSCRPSL
Sbjct: 961 DLDSDSWCLLGTDSCRPSL 979
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 405 bits (1042), Expect = e-113
Identities = 259/706 (36%), Positives = 380/706 (53%), Gaps = 54/706 (7%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y IRV+GRGAFG L R D LV+ K++ + +++++ER+ A NE +L LL H N+
Sbjct: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Query: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
I YY +F+++ L+I +EY GG L + I ++ + L EEE ++ + QI+ A+ +H
Sbjct: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
Query: 172 ILHRDIKTLNIFLTKANL-IKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230
ILHRD+KT NI L K + +K+GD+G++K L+S+ S A T+VGTP Y+SPELC+G YN
Sbjct: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK-SKAYTVVGTPCYISPELCEGKPYNQ 182
Query: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
KSDIWA+GCV++EL +LKR F+A N L +KI+ G A S +YS EL Q+V S L
Sbjct: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFA--PISDRYSPELRQLVLSLLS 240
Query: 291 QDPEQRPTADELLDRPL--------------LRKRRREMEEKVTLLNAPTKRPRSSTVTE 336
+P QRP ++ +PL +R RR E + + T R +
Sbjct: 241 LEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPR 300
Query: 337 API-AVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTW-- 393
P+ + S VY WGGG TP +L ++ + QV AG T A VT L W
Sbjct: 301 GPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNT--EVVQVAAGRTQKAGVTRSGRLILWEA 358
Query: 394 --VNMQGGTKLHGQLGHGDKASYRQPKHVEKL----QGKAIRQVSCGDDFTVCVTDEGQL 447
+ GG+ L G + QP+ + + G I+ V+CGD FT C+TD G +
Sbjct: 359 PPLGAGGGSLLPGAV------EQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGII 412
Query: 448 YAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCG 507
FGS GC+G + ++ +P + L + QV+CG +HV+ L+ +E+++WG G
Sbjct: 413 MTFGSGSNGCLGHGSLT--DISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRG 470
Query: 508 EYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLN 567
+ GRLGL + E + PQ+V +P V CG D + +LT G+ LACG N FNKLGL+
Sbjct: 471 DSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLD 530
Query: 568 QCMSGIINHEAYHEVPYTTSFTL--AKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNK 625
G + +V SFTL + L + +I G H+AA+ G TFG N+
Sbjct: 531 HLSLG-EEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQ 589
Query: 626 CGQLGVGNYK-KRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
GQLG + R + G L G ++ V+CGD FT+A ++ +++WG G GRL
Sbjct: 590 HGQLGTNTRRGSRAPCKVQG--LEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGR 647
Query: 685 TPTERPHGSDICTSWPRPIFGSLHH---VPDLSCRGWHTILIVEKV 727
D PRP+ H V +SC +T+L V V
Sbjct: 648 --------RDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSV 685
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 232 bits (591), Expect = 1e-60
Identities = 110/260 (42%), Positives = 172/260 (66%), Gaps = 2/260 (0%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y+ ++ +G G+FG+A L + TED V KE++++R+S KER ++ E+ +LA ++H NI
Sbjct: 4 YVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
Query: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
+ Y F +N +L I ++YC GG+L+ +I QK LF+E+ ++ + QI A+ +H
Sbjct: 64 VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRK 123
Query: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFK 231
ILHRDIK+ NIFLTK ++LGD+G+A+ LNS +A T +GTPYY+SPE+C+ YN K
Sbjct: 124 ILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
Query: 232 SDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQ 291
SDIWA+GCV++EL TLK F+A + NL +KI+ G + S YS +L +V +
Sbjct: 184 SDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISG--SFPPVSLHYSYDLRSLVSQLFKR 241
Query: 292 DPEQRPTADELLDRPLLRKR 311
+P RP+ + +L++ + KR
Sbjct: 242 NPRDRPSVNSILEKGFIAKR 261
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 216 bits (549), Expect = 1e-55
Identities = 119/328 (36%), Positives = 184/328 (56%), Gaps = 21/328 (6%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y +RV+G+G++GE TL + D V K+++L S +ERR A E +L+ L+H NI
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 112 IAYYNHFMDNTTLL-IELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKA 170
+ Y + LL I + +C GG+LY K+ QK +L E VV + QI A+ +H+
Sbjct: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
Query: 171 GILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230
ILHRD+KT N+FLT+ N+IK+GD G+A+ L + MA TL+GTPYYMSPEL YN+
Sbjct: 126 HILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYNY 185
Query: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
KSD+WA+GC ++E+ TLK F+A + +L +I++G + YS EL +++ + L
Sbjct: 186 KSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEG--KLPPMPRDYSPELAELIRTMLS 243
Query: 291 QDPEQRPTADELLDRPLLRKRRREMEEKVTLLNAPTKRPRSSTVTEAPIAVV-------- 342
+ PE+RP+ +L +P + KR+ + T + ++ P A V
Sbjct: 244 KRPEERPSVRSILRQPYI-KRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAESN 302
Query: 343 ---------TSRTSEVYVWGGGKSTPQK 361
+S S+ Y+ G GK Q+
Sbjct: 303 HEVIHPQPLSSEGSQTYIMGEGKCLSQE 330
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 209 bits (532), Expect = 1e-53
Identities = 105/258 (40%), Positives = 160/258 (62%), Gaps = 3/258 (1%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y I+ +G+GAFG+A L + D V KE++ ++ +E+ + E+++L ++H NI
Sbjct: 4 YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKHPNI 63
Query: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
+A++N F +N L I +EYC+GG+L +I RQ+ LF E+ ++ + QI + IH
Sbjct: 64 VAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRK 123
Query: 172 ILHRDIKTLNIFLTKANLI-KLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230
ILHRDIK NIFL+K ++ KLGD+G+A+ LN+ +A T +GTPYY+SPE+CQ YN
Sbjct: 124 ILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKPYNN 183
Query: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
K+DIW++GCV++EL TLK F+ N L +KI Q A S +S EL ++
Sbjct: 184 KTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFA--PISPGFSRELHSLISQLFQ 241
Query: 291 QDPEQRPTADELLDRPLL 308
P RP+ + +L RP L
Sbjct: 242 VSPRDRPSINSILKRPFL 259
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 201 bits (510), Expect = 4e-51
Identities = 105/259 (40%), Positives = 162/259 (62%), Gaps = 3/259 (1%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y+ +R++G G+FG A L + + + KE+ L + S +++ E V+LA ++H NI
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHPNI 62
Query: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
+A+ F L I +EYC+GG+L KI +QK KLF E+M++ + Q+ V+ IHK
Sbjct: 63 VAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKR 122
Query: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFK 231
+LHRDIK+ NIFLT+ +KLGD+G A+ L++ + A T VGTPYY+ PE+ + + YN K
Sbjct: 123 VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNK 182
Query: 232 SDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQ 291
SDIW++GC+++EL TLK F A + NL +K+ QG + S YS EL +V +
Sbjct: 183 SDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG--CISPLPSHYSYELQFLVKQMFKR 240
Query: 292 DPEQRPTADELLDRPLLRK 310
+P RP+A LL R ++ +
Sbjct: 241 NPSHRPSATTLLSRGIVAR 259
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 201 bits (510), Expect = 4e-51
Identities = 105/259 (40%), Positives = 162/259 (62%), Gaps = 3/259 (1%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y+ +R++G G+FG A L + + + KE+ L + S +++ E V+LA ++H NI
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHPNI 62
Query: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
+A+ F L I +EYC+GG+L KI +QK KLF E+M++ + Q+ V+ IHK
Sbjct: 63 VAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKR 122
Query: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFK 231
+LHRDIK+ NIFLT+ +KLGD+G A+ L++ + A T VGTPYY+ PE+ + + YN K
Sbjct: 123 VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNK 182
Query: 232 SDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQ 291
SDIW++GC+++EL TLK F A + NL +K+ QG + S YS EL +V +
Sbjct: 183 SDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG--CISPLPSHYSYELQFLVKQMFKR 240
Query: 292 DPEQRPTADELLDRPLLRK 310
+P RP+A LL R ++ +
Sbjct: 241 NPSHRPSATTLLSRGIVAR 259
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 201 bits (510), Expect = 4e-51
Identities = 105/259 (40%), Positives = 162/259 (62%), Gaps = 3/259 (1%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y+ +R++G G+FG A L + + + KE+ L + S +++ E V+LA ++H NI
Sbjct: 4 YMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHPNI 62
Query: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
+A+ F L I +EYC+GG+L KI +QK KLF E+M++ + Q+ V+ IHK
Sbjct: 63 VAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKR 122
Query: 172 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFK 231
+LHRDIK+ NIFLT+ +KLGD+G A+ L++ + A T VGTPYY+ PE+ + + YN K
Sbjct: 123 VLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNK 182
Query: 232 SDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQ 291
SDIW++GC+++EL TLK F A + NL +K+ QG + S YS EL +V +
Sbjct: 183 SDIWSLGCILYELCTLKHPFQANSWKNLILKVCQG--CISPLPSHYSYELQFLVKQMFKR 240
Query: 292 DPEQRPTADELLDRPLLRK 310
+P RP+A LL R ++ +
Sbjct: 241 NPSHRPSATTLLSRGIVAR 259
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 189 bits (481), Expect = 8e-48
Identities = 109/297 (36%), Positives = 170/297 (57%), Gaps = 16/297 (5%)
Query: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Y + +G G++G RR D ++VWKE+D ++E E++ ++E+ +L L+H NI
Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNI 67
Query: 112 IAYYNHFMD--NTTLLIELEYCNGGNLYDKILR--QKDKLFEEEMVVWYLFQIVSAVSCI 167
+ YY+ +D NTTL I +EYC GG+L I + ++ + +EE V+ + Q+ A+
Sbjct: 68 VRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKEC 127
Query: 168 HKAG-----ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPEL 222
H+ +LHRD+K N+FL +KLGD+GLA+ LN + S A+T VGTPYYMSPE
Sbjct: 128 HRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQ 187
Query: 223 CQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELI 282
+ YN KSDIW++GC+++EL L F A + L KI +G +YS EL
Sbjct: 188 MNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG--KFRRIPYRYSDELN 245
Query: 283 QMVHSCLDQDPEQRPTADELLDRPLLR-----KRRREMEEKVTLLNAPTKRPRSSTV 334
+++ L+ RP+ +E+L+ PL+ ++RR +E + L P K SS V
Sbjct: 246 EIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPV 302
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 171 bits (432), Expect = 4e-42
Identities = 101/252 (40%), Positives = 143/252 (56%), Gaps = 6/252 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE-KERRDALNEIVILALLQHDNIIAYYN 116
+GRG F E D V K+V + L + K R D + EI +L L H N+I YY
Sbjct: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYA 99
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILR-QKDKLFEEEMVVW-YLFQIVSAVSCIHKAGILH 174
F+++ L I LE + G+L I +K K E VW Y Q+ SA+ +H ++H
Sbjct: 100 SFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMH 159
Query: 175 RDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDI 234
RDIK N+F+T ++KLGD GL + +S+ + A +LVGTPYYMSPE YNFKSDI
Sbjct: 160 RDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDI 219
Query: 235 WAVGCVIFELLTLKRTF--DATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292
W++GC+++E+ L+ F D N +LC KI Q + S YS EL Q+V+ C++ D
Sbjct: 220 WSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQ-CDYPPLPSDHYSEELRQLVNMCINPD 278
Query: 293 PEQRPTADELLD 304
PE+RP + D
Sbjct: 279 PEKRPDVTYVYD 290
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 167 bits (422), Expect = 6e-41
Identities = 96/245 (39%), Positives = 139/245 (56%), Gaps = 6/245 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE-KERRDALNEIVILALLQHDNIIAYYN 116
+GRG F E D V K+V + + + K R+D + EI +L L H NII Y +
Sbjct: 85 IGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLD 144
Query: 117 HFMDNTTLLIELEYCNGGNLYD--KILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILH 174
F+++ L I LE + G+L K +++ +L E V Y Q+ SAV +H ++H
Sbjct: 145 SFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMH 204
Query: 175 RDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDI 234
RDIK N+F+T ++KLGD GL + +SE + A +LVGTPYYMSPE YNFKSDI
Sbjct: 205 RDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDI 264
Query: 235 WAVGCVIFELLTLKRTF--DATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292
W++GC+++E+ L+ F D N +LC KI Q + YS +L ++V C+ D
Sbjct: 265 WSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQ-CDYPPLPGEHYSEKLRELVSMCICPD 323
Query: 293 PEQRP 297
P QRP
Sbjct: 324 PHQRP 328
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 167 bits (422), Expect = 6e-41
Identities = 96/245 (39%), Positives = 139/245 (56%), Gaps = 6/245 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSE-KERRDALNEIVILALLQHDNIIAYYN 116
+GRG F E D V K+V + + + K R+D + EI +L L H NII Y +
Sbjct: 51 IGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLD 110
Query: 117 HFMDNTTLLIELEYCNGGNLYD--KILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILH 174
F+++ L I LE + G+L K +++ +L E V Y Q+ SAV +H ++H
Sbjct: 111 SFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMH 170
Query: 175 RDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDI 234
RDIK N+F+T ++KLGD GL + +SE + A +LVGTPYYMSPE YNFKSDI
Sbjct: 171 RDIKPANVFITATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDI 230
Query: 235 WAVGCVIFELLTLKRTF--DATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292
W++GC+++E+ L+ F D N +LC KI Q + YS +L ++V C+ D
Sbjct: 231 WSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQ-CDYPPLPGEHYSEKLRELVSMCICPD 289
Query: 293 PEQRP 297
P QRP
Sbjct: 290 PHQRP 294
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 163 bits (412), Expect = 8e-40
Identities = 92/269 (34%), Positives = 155/269 (57%), Gaps = 8/269 (2%)
Query: 52 YIPIRVLGRGAFGEATLY---RRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQH 108
Y+ + LG G+FG L + + L V KE+ + L+ E A E +L+ L H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 109 DNIIAYYNHFMDNTTLLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSC 166
I+ ++ F++ I EYC G +L DKI +Q K+F E ++ + Q++ V
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 167 IHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGV 226
+H+ ILHRD+K+ N+FL K NL+K+GD+G+++ L +A TL GTP+YMSPE +
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 227 KYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVH 286
Y+ KSDIW++ C+++E+ + F +N L++ +KIV+G + +Y EL ++
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPE--RYPKELNAIME 265
Query: 287 SCLDQDPEQRPTADELLDRPLLRKRRREM 315
S L+++P RP+A E+L P L ++ + +
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 163 bits (412), Expect = 8e-40
Identities = 92/269 (34%), Positives = 155/269 (57%), Gaps = 8/269 (2%)
Query: 52 YIPIRVLGRGAFGEATLY---RRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQH 108
Y+ + LG G+FG L + + L V KE+ + L+ E A E +L+ L H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 109 DNIIAYYNHFMDNTTLLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSC 166
I+ ++ F++ I EYC G +L DKI +Q K+F E ++ + Q++ V
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 167 IHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGV 226
+H+ ILHRD+K+ N+FL K NL+K+GD+G+++ L +A TL GTP+YMSPE +
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 227 KYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVH 286
Y+ KSDIW++ C+++E+ + F +N L++ +KIV+G + +Y EL ++
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPE--RYPKELNAIME 265
Query: 287 SCLDQDPEQRPTADELLDRPLLRKRRREM 315
S L+++P RP+A E+L P L ++ + +
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 163 bits (412), Expect = 8e-40
Identities = 92/269 (34%), Positives = 155/269 (57%), Gaps = 8/269 (2%)
Query: 52 YIPIRVLGRGAFGEATLY---RRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQH 108
Y+ + LG G+FG L + + L V KE+ + L+ E A E +L+ L H
Sbjct: 29 YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLDH 88
Query: 109 DNIIAYYNHFMDNTTLLIELEYCNGGNLYDKI--LRQKDKLFEEEMVVWYLFQIVSAVSC 166
I+ ++ F++ I EYC G +L DKI +Q K+F E ++ + Q++ V
Sbjct: 89 PAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVDY 148
Query: 167 IHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGV 226
+H+ ILHRD+K+ N+FL K NL+K+GD+G+++ L +A TL GTP+YMSPE +
Sbjct: 149 MHERRILHRDLKSKNVFL-KNNLLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQ 207
Query: 227 KYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVH 286
Y+ KSDIW++ C+++E+ + F +N L++ +KIV+G + +Y EL ++
Sbjct: 208 GYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPE--RYPKELNAIME 265
Query: 287 SCLDQDPEQRPTADELLDRPLLRKRRREM 315
S L+++P RP+A E+L P L ++ + +
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 138 bits (348), Expect = 2e-32
Identities = 110/363 (30%), Positives = 166/363 (45%), Gaps = 31/363 (8%)
Query: 357 STPQKLDVIKSGCSAR-QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYR 415
STP L+ I+ + V +G H ++ E E+Y+W G G+LGHG+++
Sbjct: 4026 STPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSW-----GEAEDGKLGHGNRSPCD 4080
Query: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLN 475
+P+ +E L+G + V+ G + CVT G LY +G YG +G + L+P +
Sbjct: 4081 RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSD--SEDQLKPKLVE 4138
Query: 476 FFLSNPVEQVSCG--DNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI 533
+ V ++CG D + LT + V+SWG G+YG+LG + P K+D L
Sbjct: 4139 ALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLG 4198
Query: 534 IVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 593
+V V+CG + LT+SG V G ++++LG H + V +
Sbjct: 4199 VVKVECGSQFSVALTKSGAVYTWGKGDYHRLG----------HGSDDHVRRPRQ---VQG 4245
Query: 594 LSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVI 653
L K+ IA G H E G + T+G N GQLG G L+ L GK+V
Sbjct: 4246 LQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAA-LQGKKVN 4304
Query: 654 RVSCGDEFTIAATDDNHIFAWGNGGNGRL-AMTPTERPHGSDICTSWPRPIFGSLHHVPD 712
RV+CG T+A + A G+L A P E H +I R LHH+ +
Sbjct: 4305 RVACGSAHTLAWSTSKPASA------GKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSE 4358
Query: 713 LSC 715
L C
Sbjct: 4359 LFC 4361
Score = 115 bits (288), Expect = 2e-25
Identities = 90/332 (27%), Positives = 148/332 (44%), Gaps = 40/332 (12%)
Query: 341 VVTSRTSEVYVWGGGKST--PQKLDVIKSGCSARQVC-----AGNTHFAVVTVEKELYTW 393
++ SR VY T PQ + G ++R + + H+ + E+Y+W
Sbjct: 464 LILSRNGRVYTQAYNSDTLAPQ----LVQGLASRNIVKIAAHSDGHHYLALAATGEVYSW 519
Query: 394 VNMQGGTKLHGQLGHGDKASYRQPKHVE----KLQGKAIRQVSCGDDFTVCVTDEGQLYA 449
GG +LGHGD +PK + K GK + ++CG ++ +T EG+LY
Sbjct: 520 GCGDGG-----RLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYT 574
Query: 450 FGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCG--DNHVVVLTRNKEVYSWGCG 507
+G YG +G + PM + V V+CG D + +T N +V+SWG G
Sbjct: 575 WGRGNYGRLGHGSSEDEAI--PMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 632
Query: 508 EYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLN 567
+YG+LG + TP+ ++ + L +V V+CG + LT+ G+V + G + +LG
Sbjct: 633 DYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG-- 690
Query: 568 QCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCN-KC 626
G H Y + L + L K+ +A G TH A+ E + ++G N +C
Sbjct: 691 ---HGTEEHVRYPK--------LLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQC 739
Query: 627 GQLGVGNYKKRLGINLLGGPLGGKQVIRVSCG 658
K L G L K ++ ++CG
Sbjct: 740 QHFDTLRVTKPEPAALPG--LDTKHIVGIACG 769
Score = 112 bits (279), Expect = 2e-24
Identities = 83/278 (29%), Positives = 132/278 (47%), Gaps = 35/278 (12%)
Query: 348 EVYVWGGGKS------------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVN 395
+V+ WG G P+ ++ +K+ R + G++H A +T ELYTW
Sbjct: 3067 KVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-RIRDIACGSSHSAALTSSGELYTW-- 3123
Query: 396 MQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCG--DDFTVCVTDEGQLYAFGSD 453
G +G+LGHGD + +PK V+ L G + QV+CG D T+ +TDEG ++++G
Sbjct: 3124 ---GLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG 3180
Query: 454 YYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLG 513
+G +G G + P + V Q+ CG + LT++ V++WG G+Y RLG
Sbjct: 3181 DFGKLGRGGSEGCNI--PQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLG 3238
Query: 514 LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGI 573
S+ PQ V+ + IV V G +T SG+V A G N+ + G +
Sbjct: 3239 HGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNG---TTT 3295
Query: 574 INHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAA 611
+N + TL + L KI +A G +H+ A
Sbjct: 3296 VNRKP----------TLVQGLEGQKITRVACGSSHSVA 3323
Score = 105 bits (261), Expect = 3e-22
Identities = 93/345 (26%), Positives = 153/345 (44%), Gaps = 37/345 (10%)
Query: 367 SGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGK 426
SG R+ AG A T+ +++ W G QLG + + P E L
Sbjct: 2940 SGSLIRKKAAGLESAA--TIRTKVFVW-----GLNDKDQLGGLKGSKIKVPSFSETLSAL 2992
Query: 427 AIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVS 486
+ QV+ G VT EG++YA G G +G+ +G + P Q+ S V++V+
Sbjct: 2993 NVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPI-PRQITALSSYVVKKVA 3051
Query: 487 C--GDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGT 544
G H LT + +V+SWG G+ G+LG S + P+ ++ K I + CG +
Sbjct: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHS 3111
Query: 545 FLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAP 604
LT SG++ GL E+ +LG + + + K L +++ +A
Sbjct: 3112 AALTSSGELYTWGLGEYGRLG-------------HGDNTTQLKPKMVKVLLGHRVIQVAC 3158
Query: 605 GK--THTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGG--PLGGKQVIRVSCGDE 660
G T A+ + G + ++G G+LG G + G N+ L G+ V ++ CG +
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSE---GCNIPQNIERLNGQGVCQIECGAQ 3215
Query: 661 FTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG 705
F++A T ++ WG G RL HGSD+ P+ + G
Sbjct: 3216 FSLALTKSGVVWTWGKGDYFRLG-------HGSDVHVRKPQVVEG 3253
Score = 101 bits (251), Expect = 4e-21
Identities = 91/364 (25%), Positives = 156/364 (42%), Gaps = 50/364 (13%)
Query: 340 AVVTSRTSEVYVWG-----------GGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEK 388
+ T RT +V+VWG G K S + QV G+ VTVE
Sbjct: 2953 SAATIRT-KVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEG 3011
Query: 389 ELYTWVNMQGGTKLHGQLGHG-DKASYRQPKHVEKLQGKAIRQVSC--GDDFTVCVTDEG 445
++Y G +G+LG G + P+ + L +++V+ G +T +G
Sbjct: 3012 KVYAC-----GEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDG 3066
Query: 446 QLYAFGSD------YYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNK 499
+++++G ++ M DK P ++E ++ + + ++CG +H LT +
Sbjct: 3067 KVFSWGEGDDGKLGHFSRMNCDK---PRLIEALK-----TKRIRDIACGSSHSAALTSSG 3118
Query: 500 EVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDG--TFLLTQSGKVLACG 557
E+Y+WG GEYGRLG P+ V V ++ V CG T LT G V + G
Sbjct: 3119 ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWG 3178
Query: 558 LNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGR 617
+F KLG I ++L+ + I G + A+ + G
Sbjct: 3179 DGDFGKLGRGGSEGCNIPQNI-------------ERLNGQGVCQIECGAQFSLALTKSGV 3225
Query: 618 LLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNG 677
+ T+G +LG G+ ++ G L GK+++ V+ G +A TD ++AWG+
Sbjct: 3226 VWTWGKGDYFRLGHGSDVHVRKPQVVEG-LRGKKIVHVAVGALHCLAVTDSGQVYAWGDN 3284
Query: 678 GNGR 681
+G+
Sbjct: 3285 DHGQ 3288
Score = 93.2 bits (230), Expect = 1e-18
Identities = 83/321 (25%), Positives = 135/321 (42%), Gaps = 34/321 (10%)
Query: 390 LYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYA 449
+Y W G GQLG + A + P E L Q+ G+ VT +G+LYA
Sbjct: 3954 IYGW-----GHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYA 4008
Query: 450 FGSDYYGCMGV---DKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGC 506
G G +G+ + V+ P +LE +Q F V+ G H + L+ EVYSWG
Sbjct: 4009 TGYGAGGRLGIGGTESVSTPTLLESIQHVFIKK---VAVNSGGKHCLALSSEGEVYSWGE 4065
Query: 507 GEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGL 566
E G+LG + P+ ++ + + +V V G + +T +G + G + +LG
Sbjct: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLG- 4124
Query: 567 NQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIA--PGKTHTAAIDERGRLLTFGCN 624
+ + L + L +++ IA G T + + + ++G
Sbjct: 4125 ------------HSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDG 4172
Query: 625 KCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
G+LG G + + L G V++V CG +F++A T ++ WG G RL
Sbjct: 4173 DYGKLGRGG-SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG- 4230
Query: 685 TPTERPHGSDICTSWPRPIFG 705
HGSD PR + G
Sbjct: 4231 ------HGSDDHVRRPRQVQG 4245
Score = 87.0 bits (214), Expect = 8e-17
Identities = 82/333 (24%), Positives = 138/333 (41%), Gaps = 46/333 (13%)
Query: 404 GQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLY--AFGSDYYGCMGVD 461
G +G A+ P E L + Q++C + + ++ G++Y A+ SD
Sbjct: 429 GLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD-------- 480
Query: 462 KVAGPEVLEPMQLNFFLSNPVEQVSCGDN--HVVVLTRNKEVYSWGCGEYGRLGLDSEED 519
L P + S + +++ + H + L EVYSWGCG+ GRLG
Sbjct: 481 ------TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVP 534
Query: 520 YYTPQKVDV----PKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIIN 575
P+ + +V + CG + +T G++ G + +LG G
Sbjct: 535 LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLG-----HGSSE 589
Query: 576 HEAYHEVPYTTSFTLAKQLSFYKIRTIA--PGKTHTAAIDERGRLLTFGCNKCGQLGVGN 633
EA +P L L K+ +A G T A+ E G++ ++G G+LG G
Sbjct: 590 DEA---IPM-----LVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGG 641
Query: 634 YKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGS 693
L+ L V++V CG +F+IA T D +++WG G N RL HG+
Sbjct: 642 SDGCKTPKLIE-KLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLG-------HGT 693
Query: 694 DICTSWPRPIFG-SLHHVPDLSCRGWHTILIVE 725
+ +P+ + G V D++ H + + E
Sbjct: 694 EEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTE 726
Score = 84.7 bits (208), Expect = 4e-16
Identities = 73/266 (27%), Positives = 128/266 (48%), Gaps = 26/266 (9%)
Query: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
DD+T+ G +Y +G ++ G +G + A +V P + L PV+ + G+ +
Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATL-RPVQLIG-GEQTLFA 3999
Query: 495 LTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALII--VAVQCGCDGTFLLTQSGK 552
+T + ++Y+ G G GRLG+ E TP ++ + + I VAV G L+ G+
Sbjct: 4000 VTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGE 4059
Query: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAI 612
V + G E KLG + + + P + + L ++ +A G H+A +
Sbjct: 4060 VYSWGEAEDGKLG--------HGNRSPCDRP-----RVIESLRGIEVVDVAAGGAHSACV 4106
Query: 613 DERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC--GDEFTIAATDDNH 670
G L T+G + G+LG + + +L L+ L G +V+ ++C GD T+ TDD+
Sbjct: 4107 TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA-LQGHRVVDIACGSGDAQTLCLTDDDT 4165
Query: 671 IFAWGNGGNGRLAMTPTERPHGSDIC 696
+++WG+G G+L GSD C
Sbjct: 4166 VWSWGDGDYGKLGR------GGSDGC 4185
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 18/118 (15%)
Query: 337 APIAVVTSRTSEVYVWGGGK------------STPQKLDVIKSGCSARQVCAGNTHFAVV 384
A ++ +++ V+ WG G PQ ++ ++ G V G H V
Sbjct: 3214 AQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLR-GKKIVHVAVGALHCLAV 3272
Query: 385 TVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVT 442
T ++Y W G HGQ G+G R+P V+ L+G+ I +V+CG +V T
Sbjct: 3273 TDSGQVYAW-----GDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 136 bits (342), Expect = 1e-31
Identities = 78/256 (30%), Positives = 140/256 (54%), Gaps = 8/256 (3%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNH 117
LG GAFG+ + E +L K ++ SE+E D + EI ILA H I+
Sbjct: 42 LGDGAFGKVYKAKNKETGALAAAKVIETK--SEEELEDYIVEIEILATCDHPYIVKLLGA 99
Query: 118 FMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDI 177
+ + L I +E+C GG + D I+ + D+ E + Q++ A++ +H I+HRD+
Sbjct: 100 YYHDGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDL 158
Query: 178 KTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPE--LCQGVK---YNFKS 232
K N+ +T I+L D+G++ K ++ +GTPY+M+PE +C+ +K Y++K+
Sbjct: 159 KAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKA 218
Query: 233 DIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292
DIW++G + E+ ++ NP+ + +KI + + S++S+E + LD++
Sbjct: 219 DIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKN 278
Query: 293 PEQRPTADELLDRPLL 308
PE RP+A +LL+ P +
Sbjct: 279 PETRPSAAQLLEHPFV 294
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 134 bits (336), Expect = 5e-31
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 7/254 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYN 116
+G G+ G + LV K++DL + ++RR+ L NE+VI+ QH+N++ YN
Sbjct: 327 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEMYN 383
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRD 176
++ L + +E+ GG L D + + EE + ++ A+S +H G++HRD
Sbjct: 384 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 440
Query: 177 IKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 236
IK+ +I LT +KL D+G +++ E ++LVGTPY+M+PEL + Y + DIW+
Sbjct: 441 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 500
Query: 237 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQR 296
+G ++ E++ + + PL I + + + S L + L +DP QR
Sbjct: 501 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR 560
Query: 297 PTADELLDRPLLRK 310
TA ELL P L K
Sbjct: 561 ATAAELLKHPFLAK 574
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 134 bits (336), Expect = 5e-31
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 7/254 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYN 116
+G G+ G + LV K++DL + ++RR+ L NE+VI+ QH+N++ YN
Sbjct: 174 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEMYN 230
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRD 176
++ L + +E+ GG L D + + EE + ++ A+S +H G++HRD
Sbjct: 231 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 287
Query: 177 IKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 236
IK+ +I LT +KL D+G +++ E ++LVGTPY+M+PEL + Y + DIW+
Sbjct: 288 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 347
Query: 237 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQR 296
+G ++ E++ + + PL I + + + S L + L +DP QR
Sbjct: 348 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR 407
Query: 297 PTADELLDRPLLRK 310
TA ELL P L K
Sbjct: 408 ATAAELLKHPFLAK 421
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 134 bits (336), Expect = 5e-31
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 7/254 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYN 116
+G G+ G + LV K++DL + ++RR+ L NE+VI+ QH+N++ YN
Sbjct: 174 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEMYN 230
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRD 176
++ L + +E+ GG L D + + EE + ++ A+S +H G++HRD
Sbjct: 231 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 287
Query: 177 IKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 236
IK+ +I LT +KL D+G +++ E ++LVGTPY+M+PEL + Y + DIW+
Sbjct: 288 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 347
Query: 237 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQR 296
+G ++ E++ + + PL I + + + S L + L +DP QR
Sbjct: 348 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR 407
Query: 297 PTADELLDRPLLRK 310
TA ELL P L K
Sbjct: 408 ATAAELLKHPFLAK 421
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 134 bits (336), Expect = 5e-31
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 7/254 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYN 116
+G G+ G + LV K++DL + ++RR+ L NE+VI+ QH+N++ YN
Sbjct: 327 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEMYN 383
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRD 176
++ L + +E+ GG L D + + EE + ++ A+S +H G++HRD
Sbjct: 384 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 440
Query: 177 IKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 236
IK+ +I LT +KL D+G +++ E ++LVGTPY+M+PEL + Y + DIW+
Sbjct: 441 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 500
Query: 237 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQR 296
+G ++ E++ + + PL I + + + S L + L +DP QR
Sbjct: 501 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR 560
Query: 297 PTADELLDRPLLRK 310
TA ELL P L K
Sbjct: 561 ATAAELLKHPFLAK 574
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 134 bits (336), Expect = 5e-31
Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 7/254 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYN 116
+G G+ G + LV K++DL + ++RR+ L NE+VI+ QH+N++ YN
Sbjct: 327 IGEGSTGIVCIATVRSSGKLVAVKKMDLRK---QQRRELLFNEVVIMRDYQHENVVEMYN 383
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRD 176
++ L + +E+ GG L D + + EE + ++ A+S +H G++HRD
Sbjct: 384 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIAAVCLAVLQALSVLHAQGVIHRD 440
Query: 177 IKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 236
IK+ +I LT +KL D+G +++ E ++LVGTPY+M+PEL + Y + DIW+
Sbjct: 441 IKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWS 500
Query: 237 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQR 296
+G ++ E++ + + PL I + + + S L + L +DP QR
Sbjct: 501 LGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQR 560
Query: 297 PTADELLDRPLLRK 310
TA ELL P L K
Sbjct: 561 ATAAELLKHPFLAK 574
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 133 bits (334), Expect = 9e-31
Identities = 79/251 (31%), Positives = 140/251 (55%), Gaps = 10/251 (3%)
Query: 56 RVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALN-EIVILALLQHDNIIAY 114
+VLG+G F + ++ + K + +R+++ +R+ ++ EI + +L H +++ +
Sbjct: 86 KVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQF 145
Query: 115 YNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILH 174
Y++F D + I LEYC+ ++ IL+ + L E E V +YL QIVS + +H+ ILH
Sbjct: 146 YHYFEDKENIYILLEYCSRRSMAH-ILKARKVLTEPE-VRYYLRQIVSGLKYLHEQEILH 203
Query: 175 RDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDI 234
RD+K N F+ +A +K+GD+GLA +L T+ GTP Y+SPE+ + +SDI
Sbjct: 204 RDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDI 263
Query: 235 WAVGCVIFELLTLKRTFDATN--PLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQD 292
WA+GCV++ +L + F+ TN C++ A S ++ S L ++
Sbjct: 264 WALGCVMYTMLLGRPPFETTNLKETYRCIR-----EARYTMPSSLLAPAKHLIASMLSKN 318
Query: 293 PEQRPTADELL 303
PE RP+ D+++
Sbjct: 319 PEDRPSLDDII 329
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 133 bits (334), Expect = 9e-31
Identities = 103/319 (32%), Positives = 154/319 (48%), Gaps = 26/319 (8%)
Query: 372 RQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQV 431
R V G H V + +YT G GQLGH + S ++P+ V L + I V
Sbjct: 37 RDVGCGLRHTVFVLDDGTVYTC-----GCNDLGQLGH--EKSRKKPEQVVALDAQNIVAV 89
Query: 432 SCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLE-PMQLNFFLSNPVEQVSCGDN 490
SCG+ T+ + D+GQ+YA+G D G +G+ V E + P + + QV+CG
Sbjct: 90 SCGEAHTLALNDKGQVYAWGLDSDGQLGL--VGSEECIRVPRNIKSLSDIQIVQVACGYY 147
Query: 491 HVVVLTRNKEVYSWGCGEYGRLGLDSE-EDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQ 549
H + L++ EV+ WG +YG+LGL ++ + +PQ + + + V G +F+LT
Sbjct: 148 HSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTL 207
Query: 550 SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHT 609
SG + G N+F +LGLN E VP L K L KI I G+ HT
Sbjct: 208 SGAIFGWGRNKFGQLGLND--------ENDRYVP-----NLLKSLRSQKIVYICCGEDHT 254
Query: 610 AAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIA-ATDD 668
AA+ + G + TFG GQLG + + + L G V ++CG + T A
Sbjct: 255 AALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKV-FELMGSIVTEIACGRQHTSAFVPSS 313
Query: 669 NHIFAWGNGGNGRLAMTPT 687
I+++G GGNG+L T
Sbjct: 314 GRIYSFGLGGNGQLGTGST 332
Score = 127 bits (318), Expect = 7e-29
Identities = 99/332 (29%), Positives = 153/332 (46%), Gaps = 32/332 (9%)
Query: 399 GTKLHGQLGHG--DKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYG 456
G GQLG G D+ +P+ + K +R V CG TV V D+G +Y G + G
Sbjct: 5 GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLG 64
Query: 457 CMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-D 515
+G +K +P Q+ + + VSCG+ H + L +VY+WG G+LGL
Sbjct: 65 QLGHEK----SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 516 SEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIIN 575
SEE P+ + + IV V CG + L+++ +V G N++ +LGL
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGT------- 173
Query: 576 HEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYK 635
+ TS L K L +A G H+ + G + +G NK GQLG+ +
Sbjct: 174 -----DCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228
Query: 636 KRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDI 695
R NLL L ++++ + CG++ T A T + +F +G GG G+L H S
Sbjct: 229 DRYVPNLLKS-LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG-------HNSTS 280
Query: 696 CTSWPRPIF---GSLHHVPDLSCRGWHTILIV 724
PR +F GS+ V +++C HT V
Sbjct: 281 HEINPRKVFELMGSI--VTEIACGRQHTSAFV 310
Score = 113 bits (283), Expect = 8e-25
Identities = 78/266 (29%), Positives = 124/266 (46%), Gaps = 21/266 (7%)
Query: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQPKHVEKLQGKAIRQVS 432
V G H + + ++Y W G GQLG G + R P++++ L I QV+
Sbjct: 89 VSCGEAHTLALNDKGQVYAW-----GLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA 143
Query: 433 CGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHV 492
CG ++ ++ +++ +G + YG +G+ + P L L P QV+ G H
Sbjct: 144 CGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT-SPQLLKSLLGIPFMQVAAGGAHS 202
Query: 493 VVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGK 552
VLT + ++ WG ++G+LGL+ E D Y P + ++ IV + CG D T LT+ G
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGG 262
Query: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAA- 611
V G + +LG N HE+ F L + + IA G+ HT+A
Sbjct: 263 VFTFGAGGYGQLGHN---------STSHEINPRKVFELMGSI----VTEIACGRQHTSAF 309
Query: 612 IDERGRLLTFGCNKCGQLGVGNYKKR 637
+ GR+ +FG GQLG G+ R
Sbjct: 310 VPSSGRIYSFGLGGNGQLGTGSTSNR 335
Score = 82.0 bits (201), Expect = 2e-15
Identities = 54/198 (27%), Positives = 93/198 (46%), Gaps = 22/198 (11%)
Query: 340 AVVTSRTSEVYVWGGGK-------------STPQKLDVIKSGCSARQVCAGNTHFAVVTV 386
++ S+ SEV+ WG K ++PQ L + G QV AG H V+T+
Sbjct: 149 SLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL-GIPFMQVAAGGAHSFVLTL 207
Query: 387 EKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQ 446
++ W G GQLG D+ P ++ L+ + I + CG+D T +T EG
Sbjct: 208 SGAIFGW-----GRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGG 262
Query: 447 LYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNK-EVYSWG 505
++ FG+ YG +G + + + P ++ + + V +++CG H + +YS+G
Sbjct: 263 VFTFGAGGYGQLGHNSTS--HEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Query: 506 CGEYGRLGLDSEEDYYTP 523
G G+LG S + +P
Sbjct: 321 LGGNGQLGTGSTSNRKSP 338
Score = 62.8 bits (151), Expect = 2e-09
Identities = 49/172 (28%), Positives = 81/172 (47%), Gaps = 21/172 (12%)
Query: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAI 612
+L G F +LGL G I+ E E P + F + K ++R + G HT +
Sbjct: 1 MLCWGNASFGQLGL-----GGIDEEIVLE-PRKSDFFINK-----RVRDVGCGLRHTVFV 49
Query: 613 DERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIF 672
+ G + T GCN GQLG +K+ + L + ++ VSCG+ T+A D ++
Sbjct: 50 LDDGTVYTCGCNDLGQLGHEKSRKKPEQVVA---LDAQNIVAVSCGEAHTLALNDKGQVY 106
Query: 673 AWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-SLHHVPDLSCRGWHTILI 723
AWG +G+L + GS+ C PR I S + ++C +H++ +
Sbjct: 107 AWGLDSDGQLGLV------GSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 152
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 133 bits (334), Expect = 9e-31
Identities = 103/319 (32%), Positives = 154/319 (48%), Gaps = 26/319 (8%)
Query: 372 RQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQV 431
R V G H V + +YT G GQLGH + S ++P+ V L + I V
Sbjct: 37 RDVGCGLRHTVFVLDDGTVYTC-----GCNDLGQLGH--EKSRKKPEQVVALDAQNIVAV 89
Query: 432 SCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLE-PMQLNFFLSNPVEQVSCGDN 490
SCG+ T+ + D+GQ+YA+G D G +G+ V E + P + + QV+CG
Sbjct: 90 SCGEAHTLALNDKGQVYAWGLDSDGQLGL--VGSEECIRVPRNIKSLSDIQIVQVACGYY 147
Query: 491 HVVVLTRNKEVYSWGCGEYGRLGLDSE-EDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQ 549
H + L++ EV+ WG +YG+LGL ++ + +PQ + + + V G +F+LT
Sbjct: 148 HSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTL 207
Query: 550 SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHT 609
SG + G N+F +LGLN E VP L K L KI I G+ HT
Sbjct: 208 SGAIFGWGRNKFGQLGLND--------ENDRYVP-----NLLKSLRSQKIVYICCGEDHT 254
Query: 610 AAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIA-ATDD 668
AA+ + G + TFG GQLG + + + L G V ++CG + T A
Sbjct: 255 AALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKV-FELMGSIVTEIACGRQHTSAFVPSS 313
Query: 669 NHIFAWGNGGNGRLAMTPT 687
I+++G GGNG+L T
Sbjct: 314 GRIYSFGLGGNGQLGTGST 332
Score = 127 bits (318), Expect = 7e-29
Identities = 99/332 (29%), Positives = 153/332 (46%), Gaps = 32/332 (9%)
Query: 399 GTKLHGQLGHG--DKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYG 456
G GQLG G D+ +P+ + K +R V CG TV V D+G +Y G + G
Sbjct: 5 GNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLG 64
Query: 457 CMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL-D 515
+G +K +P Q+ + + VSCG+ H + L +VY+WG G+LGL
Sbjct: 65 QLGHEK----SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 516 SEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIIN 575
SEE P+ + + IV V CG + L+++ +V G N++ +LGL
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGT------- 173
Query: 576 HEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYK 635
+ TS L K L +A G H+ + G + +G NK GQLG+ +
Sbjct: 174 -----DCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228
Query: 636 KRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDI 695
R NLL L ++++ + CG++ T A T + +F +G GG G+L H S
Sbjct: 229 DRYVPNLLKS-LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLG-------HNSTS 280
Query: 696 CTSWPRPIF---GSLHHVPDLSCRGWHTILIV 724
PR +F GS+ V +++C HT V
Sbjct: 281 HEINPRKVFELMGSI--VTEIACGRQHTSAFV 310
Score = 113 bits (283), Expect = 8e-25
Identities = 78/266 (29%), Positives = 124/266 (46%), Gaps = 21/266 (7%)
Query: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYRQPKHVEKLQGKAIRQVS 432
V G H + + ++Y W G GQLG G + R P++++ L I QV+
Sbjct: 89 VSCGEAHTLALNDKGQVYAW-----GLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVA 143
Query: 433 CGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHV 492
CG ++ ++ +++ +G + YG +G+ + P L L P QV+ G H
Sbjct: 144 CGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQT-SPQLLKSLLGIPFMQVAAGGAHS 202
Query: 493 VVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGK 552
VLT + ++ WG ++G+LGL+ E D Y P + ++ IV + CG D T LT+ G
Sbjct: 203 FVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGG 262
Query: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAA- 611
V G + +LG N HE+ F L + + IA G+ HT+A
Sbjct: 263 VFTFGAGGYGQLGHN---------STSHEINPRKVFELMGSI----VTEIACGRQHTSAF 309
Query: 612 IDERGRLLTFGCNKCGQLGVGNYKKR 637
+ GR+ +FG GQLG G+ R
Sbjct: 310 VPSSGRIYSFGLGGNGQLGTGSTSNR 335
Score = 82.0 bits (201), Expect = 2e-15
Identities = 54/198 (27%), Positives = 93/198 (46%), Gaps = 22/198 (11%)
Query: 340 AVVTSRTSEVYVWGGGK-------------STPQKLDVIKSGCSARQVCAGNTHFAVVTV 386
++ S+ SEV+ WG K ++PQ L + G QV AG H V+T+
Sbjct: 149 SLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL-GIPFMQVAAGGAHSFVLTL 207
Query: 387 EKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQ 446
++ W G GQLG D+ P ++ L+ + I + CG+D T +T EG
Sbjct: 208 SGAIFGW-----GRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGG 262
Query: 447 LYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNK-EVYSWG 505
++ FG+ YG +G + + + P ++ + + V +++CG H + +YS+G
Sbjct: 263 VFTFGAGGYGQLGHNSTS--HEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Query: 506 CGEYGRLGLDSEEDYYTP 523
G G+LG S + +P
Sbjct: 321 LGGNGQLGTGSTSNRKSP 338
Score = 62.8 bits (151), Expect = 2e-09
Identities = 49/172 (28%), Positives = 81/172 (47%), Gaps = 21/172 (12%)
Query: 553 VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAI 612
+L G F +LGL G I+ E E P + F + K ++R + G HT +
Sbjct: 1 MLCWGNASFGQLGL-----GGIDEEIVLE-PRKSDFFINK-----RVRDVGCGLRHTVFV 49
Query: 613 DERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIF 672
+ G + T GCN GQLG +K+ + L + ++ VSCG+ T+A D ++
Sbjct: 50 LDDGTVYTCGCNDLGQLGHEKSRKKPEQVVA---LDAQNIVAVSCGEAHTLALNDKGQVY 106
Query: 673 AWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-SLHHVPDLSCRGWHTILI 723
AWG +G+L + GS+ C PR I S + ++C +H++ +
Sbjct: 107 AWGLDSDGQLGLV------GSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 152
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 132 bits (333), Expect = 1e-30
Identities = 81/260 (31%), Positives = 137/260 (52%), Gaps = 15/260 (5%)
Query: 57 VLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDA------LNEIVILALLQHDN 110
+LG+G+F A +YR +S+ EV + + +K A NE+ I L+H +
Sbjct: 17 LLGKGSF--AGVYRA---ESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS 71
Query: 111 IIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKA 170
I+ YN+F D+ + + LE C+ G + ++ L+ + K F E ++ QI++ + +H
Sbjct: 72 ILELYNYFEDSNYVYLVLEMCHNGEM-NRYLKNRVKPFSENEARHFMHQIITGMLYLHSH 130
Query: 171 GILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230
GILHRD+ N+ LT+ IK+ D+GLA +L + TL GTP Y+SPE+ +
Sbjct: 131 GILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGL 190
Query: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
+SD+W++GC+ + LL + FD N K+V M S S+E ++H L
Sbjct: 191 ESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEM---PSFLSIEAKDLIHQLLR 247
Query: 291 QDPEQRPTADELLDRPLLRK 310
++P R + +LD P + +
Sbjct: 248 RNPADRLSLSSVLDHPFMSR 267
>gi|21359873 polo-like kinase 1 [Homo sapiens]
Length = 603
Score = 132 bits (332), Expect = 2e-30
Identities = 95/345 (27%), Positives = 161/345 (46%), Gaps = 32/345 (9%)
Query: 30 PGPSASQGPRAGGGAAEQEEL--------HYIPIRVLGRGAFGEATLYRRTEDDSLVVWK 81
PG +A P A A E E+ Y+ R LG+G F + + + K
Sbjct: 23 PGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGK 82
Query: 82 EVDLTRLSEKERRDALN-EIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKI 140
V + L + +R+ ++ EI I L H +++ ++ F DN + + LE C +L +
Sbjct: 83 IVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-- 140
Query: 141 LRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKK 200
L ++ K E +YL QIV +H+ ++HRD+K N+FL + +K+GD+GLA K
Sbjct: 141 LHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATK 200
Query: 201 LNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLC 260
+ + +TL GTP Y++PE+ ++F+ D+W++GC+++ LL K F+ + C
Sbjct: 201 VEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETS-----C 255
Query: 261 VKIVQGIRAMEVDSSQYSLE------LIQMVHSCLDQDPEQRPTADELLDRPLLRKRRRE 314
+K + + ++YS+ ++ L DP RPT +ELL+
Sbjct: 256 LKETY----LRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIP 311
Query: 315 MEEKVTLLNAPTKRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTP 359
+T L P PR S AP ++ S + V G P
Sbjct: 312 ARLPITCLTIP---PRFSI---APSSLDPSNRKPLTVLNKGLENP 350
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 132 bits (331), Expect = 2e-30
Identities = 76/253 (30%), Positives = 132/253 (52%), Gaps = 7/253 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYN 116
+G G+ G + V K++DL + ++RR+ L NE+VI+ HDN++ Y+
Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRK---QQRRELLFNEVVIMRDYHHDNVVDMYS 511
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRD 176
++ L + +E+ GG L D + + EE + ++ A+S +H G++HRD
Sbjct: 512 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIATVCLSVLRALSYLHNQGVIHRD 568
Query: 177 IKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 236
IK+ +I LT IKL D+G +++ E ++LVGTPY+M+PE+ + Y + DIW+
Sbjct: 569 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWS 628
Query: 237 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQR 296
+G ++ E++ + + PL +I + D + S L + L ++P QR
Sbjct: 629 LGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQR 688
Query: 297 PTADELLDRPLLR 309
TA ELL P L+
Sbjct: 689 ATAQELLGHPFLK 701
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 132 bits (331), Expect = 2e-30
Identities = 76/253 (30%), Positives = 132/253 (52%), Gaps = 7/253 (2%)
Query: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYN 116
+G G+ G + V K++DL + ++RR+ L NE+VI+ HDN++ Y+
Sbjct: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRK---QQRRELLFNEVVIMRDYHHDNVVDMYS 511
Query: 117 HFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRD 176
++ L + +E+ GG L D + + EE + ++ A+S +H G++HRD
Sbjct: 512 SYLVGDELWVVMEFLEGGALTDIVTHTR---MNEEQIATVCLSVLRALSYLHNQGVIHRD 568
Query: 177 IKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 236
IK+ +I LT IKL D+G +++ E ++LVGTPY+M+PE+ + Y + DIW+
Sbjct: 569 IKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWS 628
Query: 237 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQR 296
+G ++ E++ + + PL +I + D + S L + L ++P QR
Sbjct: 629 LGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQR 688
Query: 297 PTADELLDRPLLR 309
TA ELL P L+
Sbjct: 689 ATAQELLGHPFLK 701
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 132 bits (331), Expect = 2e-30
Identities = 87/285 (30%), Positives = 146/285 (51%), Gaps = 22/285 (7%)
Query: 375 CAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCG 434
C + H +T E+++W G +G+LGHG+ R+P+ +E LQG+ + Q+SCG
Sbjct: 4088 CGSDGHSMALTESGEVFSW-----GDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCG 4142
Query: 435 DDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVV 494
+ VT +G+L+ FG+ YG +G+ + ++ P ++ + QV+CG NH +
Sbjct: 4143 FKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKL--PERVTALEGYQIGQVACGLNHTLA 4200
Query: 495 LTRN-KEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKV 553
++ + V+++G G+YG+LGL + +PQK+DV + I V CG + LT+ G V
Sbjct: 4201 VSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHV 4260
Query: 554 LACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAID 613
G + +GL + + NH ++P L+ I +A G HT A+
Sbjct: 4261 YTFGQDRL--IGLPEGRAR--NHNRPQQIPV---------LAGVIIEDVAVGAEHTLALA 4307
Query: 614 ERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCG 658
G + +G N GQLG+G+ L+ G L GK V ++S G
Sbjct: 4308 SNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG-LQGKNVRQISAG 4351
Score = 106 bits (264), Expect = 1e-22
Identities = 91/358 (25%), Positives = 161/358 (44%), Gaps = 45/358 (12%)
Query: 348 EVYVWGGGKS--------TPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGG 399
+VY+WG G+ S A+QV G V+ + + G
Sbjct: 3998 DVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANGTV-----LACG 4052
Query: 400 TKLHGQLGHGDKASYRQPKHVEKLQGKAIRQV--SCGDD-FTVCVTDEGQLYAFGSDYYG 456
+G+LG G+ + LQG + Q+ SCG D ++ +T+ G+++++G YG
Sbjct: 4053 EGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYG 4112
Query: 457 CMG---VDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLG 513
+G D+ P +E +Q V Q+SCG H V+T + +++++G G+YGRLG
Sbjct: 4113 KLGHGNSDRQRRPRQIEALQ-----GEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLG 4167
Query: 514 LDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVL-ACGLNEFNKLGLNQCMSG 572
L + + P++V + I V CG + T ++ G ++ A G ++ KLGL +
Sbjct: 4168 LGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTA- 4226
Query: 573 IINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG 632
+S L I+ +A G + A+ + G + TFG ++ L G
Sbjct: 4227 ------------KSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEG 4274
Query: 633 ---NYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPT 687
N+ + I +L G + + V+ G E T+A + ++AWG+ G+L + T
Sbjct: 4275 RARNHNRPQQIPVLAGVI----IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHT 4328
Score = 104 bits (259), Expect = 5e-22
Identities = 103/371 (27%), Positives = 164/371 (44%), Gaps = 49/371 (13%)
Query: 329 PRSSTVTEAPIAVVTSRTSEVYVWGGGKS------TPQKL---DVIKSGCSARQVCAGNT 379
P S +API S T EVYVWG S T +K+ + S A+ + AG
Sbjct: 357 PDSIQTGDAPIV---SETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIEAGQY 413
Query: 380 HFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCG---DD 436
V++ + + G +G+LG GD + K + ++I++VS D
Sbjct: 414 CTFVISTDGSVRAC-----GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG 468
Query: 437 FTVCVTDEGQLYAFGSDYYGCMGVDKVAG---PEVLE-PMQLNFFLSNPVEQVSCGDNHV 492
T+ T EG+++++G YG +G + P++++ P+Q V VS G H
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQ-----GKVVVCVSAGYRHS 523
Query: 493 VVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKV-DVPKALIIVAVQCGCDGTFLLTQSG 551
+T + E+Y+WG G++GRLG P V D+ + V CG T L++ G
Sbjct: 524 AAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN---VGEVSCGSSHTIALSKDG 580
Query: 552 K-VLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTA 610
+ V + G + KLG H + V Y A Q F IR + G +
Sbjct: 581 RTVWSFGGGDNGKLG----------HGDTNRV-YKPKVIEALQGMF--IRKVCAGSQSSL 627
Query: 611 AIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNH 670
A+ G++ +GC C LG G+ + L L +++ VS GD +A + DN
Sbjct: 628 ALTSTGQVYAWGCGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNE 685
Query: 671 IFAWGNGGNGR 681
++AWGN G+
Sbjct: 686 VYAWGNNSMGQ 696
Score = 103 bits (256), Expect = 1e-21
Identities = 82/300 (27%), Positives = 143/300 (47%), Gaps = 28/300 (9%)
Query: 380 HFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVE-KLQGKAIRQVSCGDDFT 438
H T E E+++W G +G+LGHG+ ++ + PK ++ LQGK + VS G +
Sbjct: 469 HTLAFTTEGEVFSW-----GDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523
Query: 439 VCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRN 498
VT++G+LY +G +G +G + ++ +SN V +VSCG +H + L+++
Sbjct: 524 AAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVK---DISN-VGEVSCGSSHTIALSKD 579
Query: 499 -KEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACG 557
+ V+S+G G+ G+LG Y P+ ++ + + I V G + LT +G+V A
Sbjct: 580 GRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYA-- 637
Query: 558 LNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGR 617
G C+ G + EA P L ++L+ +I ++ G +H A+
Sbjct: 638 ------WGCGACL-GCGSSEATALRP-----KLIEELAATRIVDVSIGDSHCLALSHDNE 685
Query: 618 LLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAAT---DDNHIFAW 674
+ +G N GQ G GN + L G + ++S G ++A T D + AW
Sbjct: 686 VYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAW 745
Score = 86.3 bits (212), Expect = 1e-16
Identities = 66/241 (27%), Positives = 105/241 (43%), Gaps = 22/241 (9%)
Query: 483 EQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCD 542
+ + GD +V + EVY WG +L ++E P+ P ++ G
Sbjct: 358 DSIQTGDAPIV--SETCEVYVWGSNSSHQLVEGTQEKILQPKLA--PSFSDAQTIEAGQY 413
Query: 543 GTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTI 602
TF+++ G V ACG + +LGL G N+++ + T S K+ +
Sbjct: 414 CTFVISTDGSVRACGKGSYGRLGL-----GDSNNQSTLK-----KLTFEPHRSIKKVSSS 463
Query: 603 APGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFT 662
HT A G + ++G G+LG GN + L+ GPL GK V+ VS G +
Sbjct: 464 KGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHS 523
Query: 663 IAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFGSLHHVPDLSCRGWHTIL 722
A T+D ++ WG G GRL HG + P + + +V ++SC HTI
Sbjct: 524 AAVTEDGELYTWGEGDFGRLG-------HGDSNSRNIP-TLVKDISNVGEVSCGSSHTIA 575
Query: 723 I 723
+
Sbjct: 576 L 576
Score = 84.7 bits (208), Expect = 4e-16
Identities = 58/211 (27%), Positives = 98/211 (46%), Gaps = 17/211 (8%)
Query: 340 AVVTSRTSEVYVWG---------GGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKEL 390
+ + E+Y WG G ++ ++K + +V G++H + + K+
Sbjct: 523 SAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSH--TIALSKDG 580
Query: 391 YTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF 450
T + GG +G+LGHGD +PK +E LQG IR+V G ++ +T GQ+YA+
Sbjct: 581 RTVWSFGGGD--NGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
Query: 451 GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYG 510
G C+G + L P + + + VS GD+H + L+ + EVY+WG G
Sbjct: 639 GCG--ACLGCGS-SEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMG 695
Query: 511 RLGLDSEEDYYT-PQKVDVPKALIIVAVQCG 540
+ G + T P+KV + I + G
Sbjct: 696 QCGQGNSTGPITKPKKVSGLDGIAIQQISAG 726
Score = 68.9 bits (167), Expect = 2e-11
Identities = 69/263 (26%), Positives = 116/263 (44%), Gaps = 25/263 (9%)
Query: 431 VSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDN 490
+ GD V T E ++ S + G + ++L+P F + + + G
Sbjct: 360 IQTGDAPIVSETCEVYVWGSNSSHQLVEGTQE----KILQPKLAPSF--SDAQTIEAGQY 413
Query: 491 HVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKV--DVPKALIIVAVQCGCDG-TFLL 547
V++ + V + G G YGRLGL + T +K+ + +++ V+ G DG T
Sbjct: 414 CTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAF 473
Query: 548 TQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKT 607
T G+V + G ++ KLG G + + Y ++ + L + ++ G
Sbjct: 474 TTEGEVFSWGDGDYGKLG-----HGNSSTQKYPKL-------IQGPLQGKVVVCVSAGYR 521
Query: 608 HTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATD 667
H+AA+ E G L T+G G+LG G+ R N+ V VSCG TIA +
Sbjct: 522 HSAAVTEDGELYTWGEGDFGRLGHGDSNSR---NIPTLVKDISNVGEVSCGSSHTIALSK 578
Query: 668 DNH-IFAWGNGGNGRLAMTPTER 689
D ++++G G NG+L T R
Sbjct: 579 DGRTVWSFGGGDNGKLGHGDTNR 601
Score = 42.0 bits (97), Expect = 0.003
Identities = 38/133 (28%), Positives = 60/133 (45%), Gaps = 12/133 (9%)
Query: 595 SFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIR 654
SF + + + G+ T I G +L G G+LG GN L + + L G V +
Sbjct: 4025 SFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQGN-SDDLHVLTVISALQGFVVTQ 4083
Query: 655 V--SCG-DEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRPIFG-SLHHV 710
+ SCG D ++A T+ +F+WG+G G+L HG+ PR I V
Sbjct: 4084 LVTSCGSDGHSMALTESGEVFSWGDGDYGKLG-------HGNSDRQRRPRQIEALQGEEV 4136
Query: 711 PDLSCRGWHTILI 723
+SC H+ ++
Sbjct: 4137 VQMSCGFKHSAVV 4149
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,549,690
Number of Sequences: 37866
Number of extensions: 2087881
Number of successful extensions: 15960
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 741
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 11612
Number of HSP's gapped (non-prelim): 2166
length of query: 979
length of database: 18,247,518
effective HSP length: 112
effective length of query: 867
effective length of database: 14,006,526
effective search space: 12143658042
effective search space used: 12143658042
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.