Search of human proteins with 221307575

Search of human proteins with 221307575

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
         (874 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s...  1739   0.0  
gi|7662208 GTPase regulator associated with the focal adhesion k...   781   0.0  
gi|4505507 oligophrenin 1 [Homo sapiens]                              752   0.0  
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]           732   0.0  
gi|208022687 GTPase regulator associated with the focal adhesion...   724   0.0  
gi|188497642 ARHGAP15 [Homo sapiens]                                  143   6e-34
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...   125   1e-28
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...   125   1e-28
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]            118   2e-26
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]          118   2e-26
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma...   116   1e-25
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]           114   3e-25
gi|187608516 centaurin, beta 2 [Homo sapiens]                         114   5e-25
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                     113   7e-25
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                    113   7e-25
gi|23510413 sorting nexin 26 [Homo sapiens]                           111   3e-24
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]          111   3e-24
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ...   107   4e-23
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          107   5e-23
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap...   103   5e-22
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap...   103   5e-22
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap...   101   3e-21
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap...   101   3e-21
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]           100   8e-21
gi|91208437 GEM interacting protein [Homo sapiens]                     99   2e-20
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]       97   7e-20
gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]            95   3e-19
gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]            95   3e-19
gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]             95   3e-19
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]    94   7e-19

>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
           sapiens]
          Length = 874

 Score = 1739 bits (4504), Expect = 0.0
 Identities = 874/874 (100%), Positives = 874/874 (100%)

Query: 1   MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60
           MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF
Sbjct: 1   MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60

Query: 61  SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120
           SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR
Sbjct: 61  SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120

Query: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180
           KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE
Sbjct: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180

Query: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240
           YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE
Sbjct: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240

Query: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM 300
           STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM
Sbjct: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM 300

Query: 301 SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA 360
           SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA
Sbjct: 301 SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA 360

Query: 361 NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG 420
           NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG
Sbjct: 361 NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG 420

Query: 421 VNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIA 480
           VNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIA
Sbjct: 421 VNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIA 480

Query: 481 VKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTL 540
           VKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTL
Sbjct: 481 VKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTL 540

Query: 541 MRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLS 600
           MRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLS
Sbjct: 541 MRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLS 600

Query: 601 TGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKSG 660
           TGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKSG
Sbjct: 601 TGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKSG 660

Query: 661 GIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDLV 720
           GIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDLV
Sbjct: 661 GIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDLV 720

Query: 721 KKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCR 780
           KKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCR
Sbjct: 721 KKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCR 780

Query: 781 RLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSHELSFPQG 840
           RLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSHELSFPQG
Sbjct: 781 RLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSHELSFPQG 840

Query: 841 AIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL 874
           AIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL
Sbjct: 841 AIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL 874


>gi|7662208 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform a [Homo sapiens]
          Length = 814

 Score =  781 bits (2016), Expect = 0.0
 Identities = 444/882 (50%), Positives = 571/882 (64%), Gaps = 76/882 (8%)

Query: 1   MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60
           MGLP LEFSD  LDSP FRE L+ HE EL++TNKFIKELIKDG  LI AL+NLS A +KF
Sbjct: 1   MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKF 60

Query: 61  SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120
           + SL +F+F+CIGDAETDDE+ IA+SL+EFA +L  +E+ER R+I+NA++VLI PLEKFR
Sbjct: 61  ADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFR 120

Query: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180
           KEQIGAAK+ KKK+DKE+EKY  ILEKHLNLS+KKKES LQEAD+Q+D   Q+FYE SLE
Sbjct: 121 KEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLE 180

Query: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240
           YVFK+QEVQE+K FEFVEPLL+FLQGLFTFYH GYELA++F  +K QL  ++QNTRN FE
Sbjct: 181 YVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFE 240

Query: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM 300
            TR EVE LM++MK    +++  S +TMEGYLYVQEKR  G +W+KHYCTY + SK  TM
Sbjct: 241 GTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITM 300

Query: 301 SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA 360
              + KS GK         E   LKSC RRKTDSI+KRFCFD+E V+R G+IT+QA SE 
Sbjct: 301 VPFDQKSGGK-----GGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEE 355

Query: 361 NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG 420
           +R+LW+EAMDG+EP+Y        +    L+  GF+ +RKCI AVETRGI   GLYRI G
Sbjct: 356 DRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVG 415

Query: 421 VNSKVQKLMNTTFSPKSPPDIDIDI-ELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFII 479
           VNS+VQKL++    PK+  + + DI   W+ KTITS LK YLR L  PLM Y+  + FI 
Sbjct: 416 VNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIK 475

Query: 480 AVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPT 539
           A K ++Q  RV  +H+LVH+LPEKNR+ML +L+ HL  V+ + +QNLMTV+NLGV+FGPT
Sbjct: 476 AAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPT 535

Query: 540 LMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICL 599
           L+R QEETVAA+M+IKFQNIV+EILIE++EKIF+T PD  +PL   Q     ++      
Sbjct: 536 LLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPD--MPLTNAQLHLSRKK------ 587

Query: 600 STGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKS 659
           S+ S+ P      C   P +  ++       + S E     +S  NS+ +S S  P    
Sbjct: 588 SSDSKPPS-----CSERPLTLFHT-------VQSTEKQEQRNSIINSSLESVSSNPNS-- 633

Query: 660 GGIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDL 719
                    SSS+ Q ++   ++ P+ +      K    +      S TSP   S P+  
Sbjct: 634 ------ILNSSSSLQPNMN--SSDPDLA----VVKPTRPNSLPPNPSPTSPLSPSWPMFS 681

Query: 720 VKKEPYGLSGLKRASASSLRSIS-------AAEGNKSYSGSIQSLTSVGSKETPKASPNP 772
               P   S    + +S +RS++       AA        S+ ++ S+     P   PN 
Sbjct: 682 APSSPMPTSSTS-SDSSPVRSVAGFVWFSVAAVVLSLARSSLHAVFSLLVNFVP-CHPNL 739

Query: 773 DLPPKMCRRLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHS 832
            L                 + RP   V       E+  +P      R+AKA+Y+CKAEH 
Sbjct: 740 HLL----------------FDRPEEAV------HEDSSTPF-----RKAKALYACKAEHD 772

Query: 833 HELSFPQGAIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL 874
            ELSF  G +F NV+PS EPGWL+ T  GKTGL+PENYV FL
Sbjct: 773 SELSFTAGTVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFL 814


>gi|4505507 oligophrenin 1 [Homo sapiens]
          Length = 802

 Score =  752 bits (1942), Expect = 0.0
 Identities = 407/750 (54%), Positives = 507/750 (67%), Gaps = 41/750 (5%)

Query: 1   MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60
           MG P LEFSD YLDSPDFRERL+C+E ELERTNKFIK++IKDG+ LI A+RN S AVQKF
Sbjct: 1   MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60

Query: 61  SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120
           SQ+LQ FQF+ IGD  TDDEI+IA+S KEFA LL  VE ER  ++ NA+D+LI PLE FR
Sbjct: 61  SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120

Query: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180
           KEQIG  K+ KKKF+K+ E++YS+L++HL+LS+KKKES LQEAD Q+D+E  NF+E+SL+
Sbjct: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180

Query: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240
           YV++IQEVQE KKF  VEP+L+FL  LF       EL Q+F PYKQQLQ +LQNTRN+F 
Sbjct: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240

Query: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM 300
           STR+E+E L +RMK A Q  + P Q T+EGYLY QEK  LG +W+K+YC Y+K +KT TM
Sbjct: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM 300

Query: 301 SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA 360
           +  E K   K        P    LK C+RRKT+SIDKRFCFDIE  ER G ITLQA SEA
Sbjct: 301 TPMEQKPGAK------QGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEA 354

Query: 361 NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG 420
           NR+LW+EAMDGKEPIY  P  I+K++EM LNE GF FVRKCI  +ET+GI   GLYR  G
Sbjct: 355 NRRLWMEAMDGKEPIYHSP--ITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVG 412

Query: 421 VNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIA 480
            N +VQKL+N  F PK P D+D     WD KTITS LK YLR L+EP+MTY+LHK+ + A
Sbjct: 413 SNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSA 472

Query: 481 VKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTL 540
            KSD+ +YR+ A+H+LV+KLPEKNREML++LI+HLV V  HS++NLMT SN+GVIFGPTL
Sbjct: 473 AKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTL 532

Query: 541 MRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLS 600
           MRAQE+TVAAMMNIKFQNIVVEILIEH+ KI+   P+ S   P P  R  +RR + I +S
Sbjct: 533 MRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITIS 592

Query: 601 TGSRKPRG-RYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKS 659
               + R   YT  L E + +    +P+ T   SIE        +    +S    P  KS
Sbjct: 593 KRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKS 652

Query: 660 GGIPWI-------------------------ATPSSSNGQKSLGLWTTSPESSSREDATK 694
              P +                          TP ++NG       T +P    +  A +
Sbjct: 653 PSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPR 712

Query: 695 TDA---ESDCQSVASVTSPGD----VSPPI 717
             A   E D  S + V  PG+    + PP+
Sbjct: 713 PLAHHKEGDADSFSKVRPPGEKPTIIRPPV 742


>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score =  732 bits (1890), Expect = 0.0
 Identities = 424/881 (48%), Positives = 542/881 (61%), Gaps = 102/881 (11%)

Query: 1   MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60
           MGL  LEFSD YLDSP FRER++ HE ELERTNKFIKELIKDG  LI A ++LS+A +KF
Sbjct: 1   MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60

Query: 61  SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120
           + SL+DF+FE IGDA TDDE  I  SL+EF+  L  +EE+R  +  +  + LI PLEKFR
Sbjct: 61  AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120

Query: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180
           KEQ+GA K+ KKKFDKE+EK YS+++KHLNLSAKKK+SHLQEAD Q+++  Q+FYE SLE
Sbjct: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180

Query: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240
           YV K+QE+QE+KKFEFVEP+LSF QG+FTFYH+G+ELA++F  YK +LQ N+QNTRN FE
Sbjct: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240

Query: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRP--LGFTWIKHYCTYDKGSKTF 298
            TR EVE LM +++   +D++  SQ+T EGYLYVQEKRP   G +W+KHYC Y K +K F
Sbjct: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300

Query: 299 TMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGI-ITLQAF 357
            M   E +S GK+        E+F LK C +R TDSID+RFCFDIE  +R G+ +T+QAF
Sbjct: 301 NMIPFEHRSGGKLG-----DGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAF 355

Query: 358 SEANRKLWLEAMDGKEPIYTL--PAIISKKE-EMYLNEAGFNFVRKCIQAVETRGITILG 414
           SE  RK WLEA+ GKE +      AII + E    L++ GF  +RKCI AVETRGI   G
Sbjct: 356 SEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQG 415

Query: 415 LYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIEL-WDNKTITSGLKNYLRCLAEPLMTYKL 473
           LYR+ GV+SKVQ+L++     K+  ++D++    W+ KTITS LK YLR L EPLMTY+L
Sbjct: 416 LYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYEL 475

Query: 474 HKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLG 533
           H DFI+  KS     RV A+H LVHKLPEKN+EMLDIL+KHL  VS HS+QNLMTV+NLG
Sbjct: 476 HGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLG 535

Query: 534 VIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRR 593
           V+FGPTLMR QEETVAA+M++KFQNIVVEILIE++EKIF                     
Sbjct: 536 VVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIF--------------------- 574

Query: 594 TRAICLSTGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASC 653
                          R  P    P+    S+SP + P          S  Q   TK    
Sbjct: 575 ---------------RTPPDTTFPEPTCLSASPPNAP-------PRQSKRQGQRTK---- 608

Query: 654 QPREKSGGIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDV 713
                                + + ++    E    ++   +  ++   S+ S++SP   
Sbjct: 609 ---------------------RPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSP--- 644

Query: 714 SPPIDLVKKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPD 773
           SP    V   P        A   S    ++    ++ S  +Q L       T   S    
Sbjct: 645 SPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTP 704

Query: 774 LPPKMCRRLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSH 833
           L P           SS     P + VA K         P+ + S R+A+A+Y C+AEHS 
Sbjct: 705 LSP----------GSSPFPFSPPATVADKP--------PESIRS-RKARAVYPCEAEHSS 745

Query: 834 ELSFPQGAIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL 874
           ELSF  GAIF +V  S EPGWL+ T  GK GL+P+NYV  L
Sbjct: 746 ELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL 786


>gi|208022687 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform b [Homo sapiens]
          Length = 759

 Score =  724 bits (1868), Expect = 0.0
 Identities = 390/722 (54%), Positives = 499/722 (69%), Gaps = 16/722 (2%)

Query: 1   MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60
           MGLP LEFSD  LDSP FRE L+ HE EL++TNKFIKELIKDG  LI AL+NLS A +KF
Sbjct: 1   MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKF 60

Query: 61  SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120
           + SL +F+F+CIGDAETDDE+ IA+SL+EFA +L  +E+ER R+I+NA++VLI PLEKFR
Sbjct: 61  ADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFR 120

Query: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180
           KEQIGAAK+ KKK+DKE+EKY  ILEKHLNLS+KKKES LQEAD+Q+D   Q+FYE SLE
Sbjct: 121 KEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLE 180

Query: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240
           YVFK+QEVQE+K FEFVEPLL+FLQGLFTFYH GYELA++F  +K QL  ++QNTRN FE
Sbjct: 181 YVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFE 240

Query: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM 300
            TR EVE LM++MK    +++  S +TMEGYLYVQEKR  G +W+KHYCTY + SK  TM
Sbjct: 241 GTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITM 300

Query: 301 SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA 360
              + KS GK         E   LKSC RRKTDSI+KRFCFD+E V+R G+IT+QA SE 
Sbjct: 301 VPFDQKSGGK-----GGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEE 355

Query: 361 NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG 420
           +R+LW+EAMDG+EP+Y        +    L+  GF+ +RKCI AVETRGI   GLYRI G
Sbjct: 356 DRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVG 415

Query: 421 VNSKVQKLMNTTFSPKSPPDIDIDI-ELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFII 479
           VNS+VQKL++    PK+  + + DI   W+ KTITS LK YLR L  PLM Y+  + FI 
Sbjct: 416 VNSRVQKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIK 475

Query: 480 AVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPT 539
           A K ++Q  RV  +H+LVH+LPEKNR+ML +L+ HL  V+ + +QNLMTV+NLGV+FGPT
Sbjct: 476 AAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPT 535

Query: 540 LMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICL 599
           L+R QEETVAA+M+IKFQNIV+EILIE++EKIF+T PD  +PL   Q     +++     
Sbjct: 536 LLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTVPD--MPLTNAQLHLSRKKSSDSKP 593

Query: 600 STGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKS 659
            + S +P   +    +    +  +S  +S    S+ES+SS+ +  +    S+S QP   S
Sbjct: 594 PSCSERPLTLFHTVQSTEKQEQRNSIINS----SLESVSSNPN--SILNSSSSLQPNMNS 647

Query: 660 GGIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDL 719
                     +           TSP S S    +   +     S +S +SP  VS P   
Sbjct: 648 SDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSP--VSTPFRK 705

Query: 720 VK 721
            K
Sbjct: 706 AK 707



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 60/144 (41%), Positives = 77/144 (53%), Gaps = 17/144 (11%)

Query: 742 SAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCRRLRLDTASSNGYQRPGSVVAA 801
           S+ E   S   SI  L S  S +    S +PDL   + +  R ++   N    P S ++ 
Sbjct: 622 SSLESVSSNPNSI--LNSSSSLQPNMNSSDPDLA--VVKPTRPNSLPPN--PSPTSPLSP 675

Query: 802 KAQLFENVGSPKPVSSG-----------RQAKAMYSCKAEHSHELSFPQGAIFSNVYPSV 850
              +F    SP P SS            R+AKA+Y+CKAEH  ELSF  G +F NV+PS 
Sbjct: 676 SWPMFSAPSSPMPTSSTSSDSSPVSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQ 735

Query: 851 EPGWLKATYEGKTGLVPENYVVFL 874
           EPGWL+ T  GKTGL+PENYV FL
Sbjct: 736 EPGWLEGTLNGKTGLIPENYVEFL 759


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score =  143 bits (361), Expect = 6e-34
 Identities = 70/182 (38%), Positives = 112/182 (61%), Gaps = 4/182 (2%)

Query: 397 FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN-KTITS 455
           FV++CI+AVE RG+ + G+YR+ G  + +QKL    F       +++D   W++   +T 
Sbjct: 297 FVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLR---FIVNQEEKLNLDDSQWEDIHVVTG 353

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
            LK + R L EPL  Y   + F+ A+K  D N R+EAV +LV KLP  NR+ + +L  HL
Sbjct: 354 ALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHL 413

Query: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTA 575
            K+   + +NLM+  +LG++FGPTL+RA+ ET    +++ +QN + E+++  Y KIF + 
Sbjct: 414 TKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSE 473

Query: 576 PD 577
            D
Sbjct: 474 ED 475


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score =  125 bits (315), Expect = 1e-28
 Identities = 70/177 (39%), Positives = 103/177 (58%), Gaps = 4/177 (2%)

Query: 397 FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN-KTITS 455
           FV++CI+AVE RG+ I GLYRI G  + +QKL    +       +D+D   W++   IT 
Sbjct: 345 FVQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITG 401

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
            LK + R L EPL  +   + FI A+K  DQ  R   V  LV  LP  N + L +L +HL
Sbjct: 402 ALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHL 461

Query: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIF 572
            +V  H +QN M+V ++ ++FGPTL+R + E  +  M + FQN VVE++++    IF
Sbjct: 462 CRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score =  125 bits (315), Expect = 1e-28
 Identities = 70/177 (39%), Positives = 103/177 (58%), Gaps = 4/177 (2%)

Query: 397 FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN-KTITS 455
           FV++CI+AVE RG+ I GLYRI G  + +QKL    +       +D+D   W++   IT 
Sbjct: 372 FVQQCIRAVEARGLDIDGLYRISGNLATIQKLR---YKVDHDERLDLDDGRWEDVHVITG 428

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
            LK + R L EPL  +   + FI A+K  DQ  R   V  LV  LP  N + L +L +HL
Sbjct: 429 ALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHL 488

Query: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIF 572
            +V  H +QN M+V ++ ++FGPTL+R + E  +  M + FQN VVE++++    IF
Sbjct: 489 CRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score =  118 bits (296), Expect = 2e-26
 Identities = 65/176 (36%), Positives = 106/176 (60%), Gaps = 2/176 (1%)

Query: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457
           V  CI+ +E+RG+   GLYR+ G +  ++ +           DI +++   D   IT  L
Sbjct: 285 VDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNM-YEDINIITGAL 343

Query: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517
           K Y R L  PL+TY  +  FI + K  D + ++E +H  +  LP  + E L  L+ HL +
Sbjct: 344 KLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKR 403

Query: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE-ETVAAMMNIKFQNIVVEILIEHYEKIF 572
           V+LH ++NLM   NLG++FGPTLMR+ E + +AA+ +I++Q +VVE+LI++ + +F
Sbjct: 404 VTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score =  118 bits (296), Expect = 2e-26
 Identities = 65/176 (36%), Positives = 106/176 (60%), Gaps = 2/176 (1%)

Query: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457
           V  CI+ +E+RG+   GLYR+ G +  ++ +           DI +++   D   IT  L
Sbjct: 259 VDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNM-YEDINIITGAL 317

Query: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517
           K Y R L  PL+TY  +  FI + K  D + ++E +H  +  LP  + E L  L+ HL +
Sbjct: 318 KLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKR 377

Query: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE-ETVAAMMNIKFQNIVVEILIEHYEKIF 572
           V+LH ++NLM   NLG++FGPTLMR+ E + +AA+ +I++Q +VVE+LI++ + +F
Sbjct: 378 VTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433


>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
           3 [Homo sapiens]
          Length = 834

 Score =  116 bits (290), Expect = 1e-25
 Identities = 101/379 (26%), Positives = 170/379 (44%), Gaps = 36/379 (9%)

Query: 5   TLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSL 64
           T+EF +   DSP FR  +   E ++      + +L+K  S ++ A +      + F   +
Sbjct: 2   TVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGV 61

Query: 65  QDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQI 124
           +D   +C GD        I++ L+ FA  L  V      L   A   +   L+ F KE +
Sbjct: 62  RDLSQQCQGDTV------ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDV 115

Query: 125 GAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESH-LQEADTQIDREHQNFYEASLEYVF 183
              K+ KK+FDK  E     L +  N  A +   H ++EA   +    + F   +L+YV 
Sbjct: 116 RKFKETKKQFDKVREDLELSLVR--NAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVL 173

Query: 184 KIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFESTR 243
           +I  +Q KKKFE ++ +LSF+    +F+ +GY L  +  PY ++L   L     +    +
Sbjct: 174 QINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEK 233

Query: 244 QEVER----LMQRM---------KSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCT 290
           +E+ER    + QR               D   PS   MEGYL+ +       TW + +  
Sbjct: 234 REMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFK-TWNRRW-- 290

Query: 291 YDKGSKTFTMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHG 350
                  F++  S++    K+   +T   +   L+ C  +  + I++RFCF  EV+    
Sbjct: 291 -------FSIQNSQLVYQKKLKDALTVVVD--DLRLCSVKPCEDIERRFCF--EVLSPTK 339

Query: 351 IITLQAFSEANRKLWLEAM 369
              LQA SE  R+ W++A+
Sbjct: 340 SCMLQADSEKLRQAWVQAV 358


>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
          Length = 846

 Score =  114 bits (286), Expect = 3e-25
 Identities = 61/177 (34%), Positives = 106/177 (59%), Gaps = 5/177 (2%)

Query: 397 FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN-KTITS 455
           FV+ CI+ VE  G+ I G+YR+ G  + +QKL    F+      +D++   W++   IT 
Sbjct: 672 FVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLR---FAVNHDEKLDLNDSKWEDIHVITG 728

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
            LK + R L EPL T+    DF+ A+K + +  RV AV  L+ +LP+ N++ + IL +HL
Sbjct: 729 ALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQ-RVAAVKDLIRQLPKPNQDTMQILFRHL 787

Query: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIF 572
            +V  + ++N MT  ++ ++FGPTL++ ++ET    ++  +QN +VE+++     IF
Sbjct: 788 RRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIF 844


>gi|187608516 centaurin, beta 2 [Homo sapiens]
          Length = 778

 Score =  114 bits (284), Expect = 5e-25
 Identities = 94/375 (25%), Positives = 177/375 (47%), Gaps = 32/375 (8%)

Query: 5   TLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSL 64
           T++F +   DSP FR  L+  E ++      + +L+K    +I   +   +A ++F   +
Sbjct: 4   TVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGI 63

Query: 65  QDFQFECIGDAETDDEIS-IAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQ 123
           +D       DA  +  ++  + SL+E       + ++ +R I+       A L+ F KE 
Sbjct: 64  RDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIK-------AQLQNFVKED 116

Query: 124 IGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLEYVF 183
           +   KD KK+F+K SE+  + L K+  +  + K+  ++EA   +    + F   +L+YV 
Sbjct: 117 LRKFKDAKKQFEKVSEEKENALVKNAQVQ-RNKQHEVEEATNILTATRKCFRHIALDYVL 175

Query: 184 KIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFESTR 243
           +I  +Q K++ E ++ +LSF+     F+H+GY+L  E  PY + L   L     +    +
Sbjct: 176 QINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEK 235

Query: 244 QEVER---LMQRMKSANQDYR------PPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKG 294
           +E+E+    +Q+   ++ D +        +   MEGYL+ +       TW + +      
Sbjct: 236 REMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFK-TWNRRW------ 288

Query: 295 SKTFTMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITL 354
              F++  +++    K     T   E   L+ C  +  + I++RFCF  EVV       L
Sbjct: 289 ---FSIQNNQLVYQKKFKDNPTVVVE--DLRLCTVKHCEDIERRFCF--EVVSPTKSCML 341

Query: 355 QAFSEANRKLWLEAM 369
           QA SE  R+ W++A+
Sbjct: 342 QADSEKLRQAWIKAV 356


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score =  113 bits (283), Expect = 7e-25
 Identities = 62/173 (35%), Positives = 100/173 (57%), Gaps = 2/173 (1%)

Query: 401 CIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNY 460
           CI+ +E RG+   GLYR+ G    ++ +           DI  ++   D   IT  LK Y
Sbjct: 297 CIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYP-DINIITGALKLY 355

Query: 461 LRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSL 520
            R L  P++TY  +  FI A K  + + R+EAVH ++  LP  + E L  L+ HL KV++
Sbjct: 356 FRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTM 415

Query: 521 HSQQNLMTVSNLGVIFGPTLMRAQEE-TVAAMMNIKFQNIVVEILIEHYEKIF 572
           + + N M   NLG++FGPTLMR  E+ T+  + ++++Q ++V+ILIE+ + +F
Sbjct: 416 NEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 468


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score =  113 bits (283), Expect = 7e-25
 Identities = 62/173 (35%), Positives = 100/173 (57%), Gaps = 2/173 (1%)

Query: 401 CIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNY 460
           CI+ +E RG+   GLYR+ G    ++ +           DI  ++   D   IT  LK Y
Sbjct: 161 CIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYP-DINIITGALKLY 219

Query: 461 LRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSL 520
            R L  P++TY  +  FI A K  + + R+EAVH ++  LP  + E L  L+ HL KV++
Sbjct: 220 FRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTM 279

Query: 521 HSQQNLMTVSNLGVIFGPTLMRAQEE-TVAAMMNIKFQNIVVEILIEHYEKIF 572
           + + N M   NLG++FGPTLMR  E+ T+  + ++++Q ++V+ILIE+ + +F
Sbjct: 280 NEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF 332


>gi|23510413 sorting nexin 26 [Homo sapiens]
          Length = 1126

 Score =  111 bits (277), Expect = 3e-24
 Identities = 94/343 (27%), Positives = 164/343 (47%), Gaps = 38/343 (11%)

Query: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457
           +R C + +E  G+ + G+YR+ GV+S +Q+L +  F  +  P++     L D  +++S  
Sbjct: 332 LRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHE-FDSERIPELSGPAFLQDIHSVSSLC 389

Query: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517
           K Y R L  PL+TY+L+  F  A+    +  R+  VH ++ +LP  +   L+ L++HL +
Sbjct: 390 KLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLAR 449

Query: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE-ETV-----AAMMNIKFQNIVVEILIEHYEKI 571
           ++ HS    M   NL +++ P L+R+ E E+V     AA   ++ Q++VVE L+ H + +
Sbjct: 450 MARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVL 509

Query: 572 FHTA-------PDPSIPLPQPQSRSGS-RRTRAICLSTGSRKPRGRY-TPCLAEPDSDSY 622
           F          P     LP+P+S +GS   TR + L     + +GR  TP   EP +   
Sbjct: 510 FSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTP--TEPTTPKA 567

Query: 623 SSSPDSTPMGSIESLSSHSSEQNSTTKS------ASCQPREKSGGIPWI----ATPSSSN 672
            +SP     G  E          S+ K+          PR+K   +PW+    A P  S 
Sbjct: 568 PASPAERRKG--ERGEKQRKPGGSSWKTFFALGRGPSVPRKKP--LPWLGGTRAPPQPSG 623

Query: 673 GQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSP 715
            +      T +  S+  E++  + A S  + + +  +P   +P
Sbjct: 624 SRPD----TVTLRSAKSEESLSSQA-SGAELLGAGGAPASATP 661


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score =  111 bits (277), Expect = 3e-24
 Identities = 118/456 (25%), Positives = 189/456 (41%), Gaps = 75/456 (16%)

Query: 401  CIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELW-DNKTITSGLKN 459
            C + VE RG+   G+YR+ G N+ +  +       K   DIDI  + W D   I+S LK+
Sbjct: 1168 CCKLVEERGLEYTGIYRVPGNNAAISSMQEEL--NKGMADIDIQDDKWRDLNVISSLLKS 1225

Query: 460  YLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVS 519
            + R L EPL T   + DFI A + +D   R++ +  L+H LPE + E L  L  HL  V+
Sbjct: 1226 FFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVA 1285

Query: 520  LHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMM-NIKFQNIVVEILIEHYEKIFHTAPDP 578
             +S++N M   NL ++FGPTL+R  E+ +  M+ ++  Q  +VE LI+H++  F T    
Sbjct: 1286 ENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF-TEEGA 1344

Query: 579  SIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLS 638
              PL   Q                                     S+ DS P+ +I+ L 
Sbjct: 1345 EEPLTTVQE-----------------------------------ESTVDSQPVPNIDHLL 1369

Query: 639  SHSSEQNSTTKSASCQPREKSGGIPW-IATPSSSNGQKSLGLWTTSPESSSRE---DATK 694
            ++                 ++G  P  ++  ++S+  KS G W +  +  SRE    +  
Sbjct: 1370 TNIG---------------RTGVSPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIF 1414

Query: 695  TDAESDCQSVASVTSPGDVSPPIDLV--KKEPYGL--------SGLKRASASSLRSISAA 744
              A    +       P      +D V  KKE            S  +  +    + I  A
Sbjct: 1415 AAASRKRKKPKEKAQPSSSEDELDNVFFKKENVEQCHNDTKEESKKESETLGRKQKIIIA 1474

Query: 745  EGN---KSYSGSIQSLTSVGSKETPKASPNPDLPPKMCRRLRLDTASSNGYQRPGSVVAA 801
            + N   K  S +     S+G + TP   P+P    K  +   L    +   + P S++A 
Sbjct: 1475 KENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQ 1534

Query: 802  KAQLFENVGSPKPV---SSGRQAKAMYSCKAEHSHE 834
            K+   E  GS       +S + + A +S K   S E
Sbjct: 1535 KSSHLEETGSDSGTLLSTSSQASLARFSMKKSTSPE 1570


>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
            sapiens]
          Length = 1499

 Score =  107 bits (268), Expect = 4e-23
 Identities = 66/241 (27%), Positives = 119/241 (49%), Gaps = 16/241 (6%)

Query: 397  FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSG 456
            F+ +CI+ +E  G++  G+YR+ G  S+++ L           ++D+  + +   T+   
Sbjct: 1264 FIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQF---DQDHNLDLAEKDFTVNTVAGA 1320

Query: 457  LKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLV 516
            +K++   L +PL+ Y +  D + A K +D+  ++ A+  ++ K P++N E+   +I HL 
Sbjct: 1321 MKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLN 1380

Query: 517  KVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAP 576
            KVS +++ NLMT  NL + F PTLMR    T+ A+   +    ++E+ I+     F+  P
Sbjct: 1381 KVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRP 1440

Query: 577  DPSIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIES 636
                P  +P S S          +  S  P    TP  ++P   S   SP  TP   ++ 
Sbjct: 1441 ITEPPGARPSSPS----------AVASTVPFLTSTPVTSQP---SPPQSPPPTPQSPMQP 1487

Query: 637  L 637
            L
Sbjct: 1488 L 1488


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score =  107 bits (267), Expect = 5e-23
 Identities = 95/363 (26%), Positives = 160/363 (44%), Gaps = 21/363 (5%)

Query: 398  VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELW-DNKTITSG 456
            V  C + VE RG+   G+YR+ G N+ V  L       + P DI++  E W D   I+S 
Sbjct: 829  VAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQL--NRGPGDINLQDERWQDLNVISSL 886

Query: 457  LKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLV 516
            LK++ R L EPL T   + DFI A + +D   R+  +  L+  LP    E L  L+ HL 
Sbjct: 887  LKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLK 946

Query: 517  KVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMM-NIKFQNIVVEILIEHYEKIFHTA 575
             ++ HS++N M   NL ++FGPTL+R  E+ +  M+ ++  +  +VE LI+H +  F   
Sbjct: 947  TIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDE 1006

Query: 576  PDPSIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIE 635
             D     P      G +  +A+          GR  P   +P SDS + S   +      
Sbjct: 1007 EDKGERTP-----VGDKEPQAVPNIEYLLPNIGRTVP-PGDPGSDSTTCSSAKSKGSWAP 1060

Query: 636  SLSSHSSEQNSTT-KSASCQPREKSGGIPWIATPSSSNGQKSLGLWTTSPESSSREDATK 694
                ++ E  + +  SA  + R+K      + + +  + ++        P + +    T+
Sbjct: 1061 KKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQE----AHKPGAGATAPGTQ 1116

Query: 695  TDAESDCQSVASVTSPGDVSPPIDLVKKEPYG-----LSGLKRASASSLRSISAAEGNKS 749
               +       +  +PG +SPP    ++ P       +SG    S       S A G ++
Sbjct: 1117 ERPQGPLPGAVAPEAPGRLSPPA-APEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRA 1175

Query: 750  YSG 752
             +G
Sbjct: 1176 GAG 1178


>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
           sapiens]
          Length = 890

 Score =  103 bits (258), Expect = 5e-22
 Identities = 59/181 (32%), Positives = 103/181 (56%), Gaps = 8/181 (4%)

Query: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457
           ++ C + VE  G+ + G+YR+ GV+S +QKL    F  +  PD+  D+ L D   ++S  
Sbjct: 37  LKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQE-FESERKPDLRRDVYLQDIHCVSSLC 94

Query: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517
           K Y R L +PL+TY+L+  F  AV    +  R+  +  ++ +LP  N   L+ L++HLV 
Sbjct: 95  KAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVH 154

Query: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE------ETVAAMMNIKFQNIVVEILIEHYEKI 571
           ++  S Q  M   NL +++ P L+R+++         AA M ++ Q+IVVE ++ H +++
Sbjct: 155 MASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQL 214

Query: 572 F 572
           F
Sbjct: 215 F 215


>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
           sapiens]
          Length = 1101

 Score =  103 bits (258), Expect = 5e-22
 Identities = 59/181 (32%), Positives = 103/181 (56%), Gaps = 8/181 (4%)

Query: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457
           ++ C + VE  G+ + G+YR+ GV+S +QKL    F  +  PD+  D+ L D   ++S  
Sbjct: 37  LKSCAEFVEEYGV-VDGIYRLSGVSSNIQKLRQE-FESERKPDLRRDVYLQDIHCVSSLC 94

Query: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVK 517
           K Y R L +PL+TY+L+  F  AV    +  R+  +  ++ +LP  N   L+ L++HLV 
Sbjct: 95  KAYFRELPDPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVH 154

Query: 518 VSLHSQQNLMTVSNLGVIFGPTLMRAQE------ETVAAMMNIKFQNIVVEILIEHYEKI 571
           ++  S Q  M   NL +++ P L+R+++         AA M ++ Q+IVVE ++ H +++
Sbjct: 155 MASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQL 214

Query: 572 F 572
           F
Sbjct: 215 F 215


>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
           sapiens]
          Length = 731

 Score =  101 bits (251), Expect = 3e-21
 Identities = 59/193 (30%), Positives = 101/193 (52%), Gaps = 16/193 (8%)

Query: 396 NFVRKCIQAVETRGITILGLYRIGGVNSKVQKLM------------NTTFSPKSPPD--- 440
           +F+R CI AV+ RG+ + G+YR+ G  + VQKL                  P+ P     
Sbjct: 538 SFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGR 597

Query: 441 IDIDIELWDN-KTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHK 499
           +D+D   WD+   +T  LK +LR L +PL+   L   F  A+   +    +  +  L+  
Sbjct: 598 LDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGS 657

Query: 500 LPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNI 559
           +P+ N + L  L++HL +V  HS +N MT  NLG++FGPTL R ++ET     +  +   
Sbjct: 658 MPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQ 717

Query: 560 VVEILIEHYEKIF 572
           +V++++ ++  +F
Sbjct: 718 LVQLMLTNFTSLF 730


>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
           sapiens]
          Length = 547

 Score =  101 bits (251), Expect = 3e-21
 Identities = 59/193 (30%), Positives = 101/193 (52%), Gaps = 16/193 (8%)

Query: 396 NFVRKCIQAVETRGITILGLYRIGGVNSKVQKLM------------NTTFSPKSPPD--- 440
           +F+R CI AV+ RG+ + G+YR+ G  + VQKL                  P+ P     
Sbjct: 354 SFLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGR 413

Query: 441 IDIDIELWDN-KTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHK 499
           +D+D   WD+   +T  LK +LR L +PL+   L   F  A+   +    +  +  L+  
Sbjct: 414 LDLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGS 473

Query: 500 LPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNI 559
           +P+ N + L  L++HL +V  HS +N MT  NLG++FGPTL R ++ET     +  +   
Sbjct: 474 MPKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQ 533

Query: 560 VVEILIEHYEKIF 572
           +V++++ ++  +F
Sbjct: 534 LVQLMLTNFTSLF 546


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score =  100 bits (248), Expect = 8e-21
 Identities = 58/201 (28%), Positives = 107/201 (53%), Gaps = 11/201 (5%)

Query: 389 YLNEAGFNF---VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDI 445
           YL  +G +    ++ C + +ET GI + G+YR+ GV S +Q+L    F     PD+  ++
Sbjct: 26  YLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQE-FGSDQCPDLTREV 83

Query: 446 ELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNR 505
            L D   + S  K Y R L  PL+TY+L++ F  AV    +  ++  +  ++ +LP  + 
Sbjct: 84  YLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHY 143

Query: 506 EMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETV------AAMMNIKFQNI 559
             L+ LI+HL  ++  S +  M   NL +++ P L+R++E         AA + ++ Q +
Sbjct: 144 RTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQV 203

Query: 560 VVEILIEHYEKIFHTAPDPSI 580
           V+E ++ H ++IF+     S+
Sbjct: 204 VIEFILNHVDQIFNNGAPGSL 224


>gi|91208437 GEM interacting protein [Homo sapiens]
          Length = 970

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 108/415 (26%), Positives = 177/415 (42%), Gaps = 53/415 (12%)

Query: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKT--ITS 455
           V KC   +E R + + G+YR+ G   +V++L     + ++       +EL  N    ++S
Sbjct: 568 VTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRAL------VELSGNSPHDVSS 621

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKS------DDQNYR------VEAVHALVHKLPEK 503
            LK +L+ L EP++ + L+  FI   K+      DD          + ++  L+ +LP+ 
Sbjct: 622 VLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLLVQLPDS 681

Query: 504 NREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMR-------AQEETVAAMMNIKF 556
           N   L  L+ HL +V+    +N M+ +NLG++FGPTL+R       A    V  +++   
Sbjct: 682 NYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSGH 741

Query: 557 QNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAE 616
           Q  +VE LI HYE+IF     P    P PQ  S +       L+T S+ P     P   +
Sbjct: 742 QAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGP----LTTSSQPP-----PPHLD 792

Query: 617 PDSDS--YSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPRE------KSGG--IPWIA 666
           PDS     +S P   P     +L  H +   +   +     RE      K GG  +    
Sbjct: 793 PDSQPPVLASDPGPDPQHH-STLEQHPTATPTEIPTPQSDQREDVAEDTKDGGGEVSSQG 851

Query: 667 TPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDLVKKEPYG 726
              S  G +S G ++  P    R        +    S+A V S      PI  V +    
Sbjct: 852 PEDSLLGTQSRGHFSRQPVKYPRGGVRPVTHQ--LSSLALVASKLCEETPITSVPRGSLR 909

Query: 727 LSGLKRASA----SSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPK 777
             G   A+A    S LR     +  +    + + L+ + S+  P+A+  PD+ P+
Sbjct: 910 GRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCCPDVQPE 964


>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
          Length = 1136

 Score = 97.1 bits (240), Expect = 7e-20
 Identities = 67/227 (29%), Positives = 113/227 (49%), Gaps = 35/227 (15%)

Query: 398 VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGL 457
           V+KC+  +E R +   G+YR+ GV ++V+KL     + K      +++       I++ L
Sbjct: 778 VKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKEL----VELSQASPHDISNVL 833

Query: 458 KNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHA---------------------- 495
           K YLR L EPL++++L+ + ++ +  D      EA  A                      
Sbjct: 834 KLYLRQLPEPLISFRLYHE-LVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLR 892

Query: 496 -LVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQ--EETV--AA 550
            L+  LP +NR  L  L++HL ++    Q N MT  NLG++FGPTL+R +  E TV  ++
Sbjct: 893 ELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSS 952

Query: 551 MMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAI 597
           +++   Q  V+E LI HY  +F   P+ +   P  Q  S ++R   +
Sbjct: 953 LVDYPHQARVIETLIVHYGLVFEEEPEET---PGGQDESSNQRAEVV 996


>gi|186910302 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 60/173 (34%), Positives = 99/173 (57%), Gaps = 7/173 (4%)

Query: 396 NFVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITS 455
           + V  C+  +E RG+T  GLYRI G +  V++L       K+ P +    ++ D   I S
Sbjct: 364 SIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLS---KVDDIHAICS 420

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
            LK++LR L EPL+T++L++ F+ A +  D++  + A++  V +LP+ NR+ L  L+ HL
Sbjct: 421 LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL 480

Query: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMR---AQEETVAAMMNIKFQNIVVEILI 565
            +V+  S    M V+NL  +FGPT++       + V  + +IK Q  VVE L+
Sbjct: 481 QRVA-QSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLL 532


>gi|186910300 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 60/173 (34%), Positives = 99/173 (57%), Gaps = 7/173 (4%)

Query: 396 NFVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITS 455
           + V  C+  +E RG+T  GLYRI G +  V++L       K+ P +    ++ D   I S
Sbjct: 364 SIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLS---KVDDIHAICS 420

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
            LK++LR L EPL+T++L++ F+ A +  D++  + A++  V +LP+ NR+ L  L+ HL
Sbjct: 421 LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL 480

Query: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMR---AQEETVAAMMNIKFQNIVVEILI 565
            +V+  S    M V+NL  +FGPT++       + V  + +IK Q  VVE L+
Sbjct: 481 QRVA-QSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLL 532


>gi|21361397 Rac GTPase activating protein 1 [Homo sapiens]
          Length = 632

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 60/173 (34%), Positives = 99/173 (57%), Gaps = 7/173 (4%)

Query: 396 NFVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITS 455
           + V  C+  +E RG+T  GLYRI G +  V++L       K+ P +    ++ D   I S
Sbjct: 364 SIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLS---KVDDIHAICS 420

Query: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
            LK++LR L EPL+T++L++ F+ A +  D++  + A++  V +LP+ NR+ L  L+ HL
Sbjct: 421 LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL 480

Query: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMR---AQEETVAAMMNIKFQNIVVEILI 565
            +V+  S    M V+NL  +FGPT++       + V  + +IK Q  VVE L+
Sbjct: 481 QRVA-QSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLL 532


>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
          Length = 2087

 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 60/226 (26%), Positives = 117/226 (51%), Gaps = 15/226 (6%)

Query: 389 YLNEAGFNF---VRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDI 445
           +L  +GF     ++ C   +E  GI + G+YR+ GV S +Q+L +  F  +  PD+  + 
Sbjct: 377 HLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHE-FDSEHVPDLTKEP 434

Query: 446 ELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNR 505
            + D  ++ S  K Y R L  PL+TY+L++ F  AV +     R+  +H ++ +LP  + 
Sbjct: 435 YVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHY 494

Query: 506 EMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQE------ETVAAMMNIKFQNI 559
             L+ L++HL  ++ +     M   NL +++ P L+R+++         AA M ++ Q++
Sbjct: 495 RTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSV 554

Query: 560 VVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLSTGSRK 605
           VVE ++ H + +F       I +   +  +   R +++ +S+ S K
Sbjct: 555 VVEFILNHVDVLF----SGRISMAMQEGAASLSRPKSLLVSSPSTK 596


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,592,041
Number of Sequences: 37866
Number of extensions: 1562041
Number of successful extensions: 6611
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 456
Number of HSP's that attempted gapping in prelim test: 5664
Number of HSP's gapped (non-prelim): 1171
length of query: 874
length of database: 18,247,518
effective HSP length: 111
effective length of query: 763
effective length of database: 14,044,392
effective search space: 10715871096
effective search space used: 10715871096
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.