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Search of human proteins with 221219048
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
sapiens]
(706 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ... 1420 0.0
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s... 1358 0.0
gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ... 1052 0.0
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens] 867 0.0
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens] 861 0.0
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ... 843 0.0
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ... 842 0.0
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ... 837 0.0
gi|39812027 amino-terminal enhancer of split isoform c [Homo sap... 209 9e-54
gi|39812019 amino-terminal enhancer of split isoform a [Homo sap... 207 4e-53
gi|5706731 amino-terminal enhancer of split isoform b [Homo sapi... 207 4e-53
gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo... 162 8e-40
gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo ... 162 8e-40
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 75 3e-13
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 75 3e-13
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 75 3e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 71 3e-12
gi|26665869 WD repeat domain 51B [Homo sapiens] 69 1e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 68 3e-11
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 66 1e-10
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 66 1e-10
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 66 1e-10
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 65 3e-10
gi|113865883 WD repeat domain 38 [Homo sapiens] 64 5e-10
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 63 1e-09
gi|21071067 TBP-associated factor 5 [Homo sapiens] 62 1e-09
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 61 3e-09
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 60 5e-09
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 60 5e-09
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 60 7e-09
>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
sapiens]
Length = 706
Score = 1420 bits (3676), Expect = 0.0
Identities = 706/706 (100%), Positives = 706/706 (100%)
Query: 1 MVQSRLTATSASQDSPASGLQTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECE 60
MVQSRLTATSASQDSPASGLQTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECE
Sbjct: 1 MVQSRLTATSASQDSPASGLQTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECE 60
Query: 61 KLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAV 120
KLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAV
Sbjct: 61 KLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAV 120
Query: 121 ERAKQVTVGELNSLIGQQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQL 180
ERAKQVTVGELNSLIGQQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQL
Sbjct: 121 ERAKQVTVGELNSLIGQQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQL 180
Query: 181 AAAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPY 240
AAAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPY
Sbjct: 181 AAAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPY 240
Query: 241 ESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRA 300
ESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRA
Sbjct: 241 ESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRA 300
Query: 301 KELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLS 360
KELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLS
Sbjct: 301 KELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLS 360
Query: 361 SPFTTSFSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVS 420
SPFTTSFSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVS
Sbjct: 361 SPFTTSFSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVS 420
Query: 421 SSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTIS 480
SSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTIS
Sbjct: 421 SSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTIS 480
Query: 481 GSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEAST 540
GSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEAST
Sbjct: 481 GSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEAST 540
Query: 541 LSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQ 600
LSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQ
Sbjct: 541 LSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQ 600
Query: 601 GHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLA 660
GHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLA
Sbjct: 601 GHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLA 660
Query: 661 VGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCVQGVVLSPEL 706
VGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCVQGVVLSPEL
Sbjct: 661 VGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCVQGVVLSPEL 706
>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
sapiens]
Length = 743
Score = 1358 bits (3514), Expect = 0.0
Identities = 674/675 (99%), Positives = 674/675 (99%), Gaps = 1/675 (0%)
Query: 22 TPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 81
TPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY
Sbjct: 9 TPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 68
Query: 82 GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQLQ 141
GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQ LQ
Sbjct: 69 GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQ-LQ 127
Query: 142 PLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERA 201
PLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERA
Sbjct: 128 PLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERA 187
Query: 202 PSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEP 261
PSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEP
Sbjct: 188 PSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEP 247
Query: 262 PSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSS 321
PSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSS
Sbjct: 248 PSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSS 307
Query: 322 PPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSV 381
PPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSV
Sbjct: 308 PPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSV 367
Query: 382 PSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADG 441
PSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADG
Sbjct: 368 PSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADG 427
Query: 442 QMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQ 501
QMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQ
Sbjct: 428 QMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQ 487
Query: 502 PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSA 561
PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSA
Sbjct: 488 PGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSA 547
Query: 562 PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG 621
PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG
Sbjct: 548 PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTG 607
Query: 622 GLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQL 681
GLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQL
Sbjct: 608 GLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQL 667
Query: 682 HLHESCVLSLKFASC 696
HLHESCVLSLKFASC
Sbjct: 668 HLHESCVLSLKFASC 682
>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
sapiens]
Length = 621
Score = 1052 bits (2720), Expect = 0.0
Identities = 538/630 (85%), Positives = 544/630 (86%), Gaps = 72/630 (11%)
Query: 69 MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 128
MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV
Sbjct: 1 MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60
Query: 129 GELNSLIGQQQLQPLSHHAPPVPLT--PRPAGLVGGSATGLLALSGALAAQAQLAAAVKE 186
GELNSLIG + +PP L RP+G GG
Sbjct: 61 GELNSLIGS------ASPSPPESLVEEERPSGPGGGG----------------------- 91
Query: 187 DRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDK 246
+ +E+ PSG PYESDEDK
Sbjct: 92 -------------------------KQRADEKEPSG----------------PYESDEDK 110
Query: 247 SDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILN 306
SDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILN
Sbjct: 111 SDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILN 170
Query: 307 DLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTS 366
DLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTS
Sbjct: 171 DLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTS 230
Query: 367 FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSI 426
FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSI
Sbjct: 231 FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSI 290
Query: 427 PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHV 486
PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHV
Sbjct: 291 PGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHV 350
Query: 487 YTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDL 546
YTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDL
Sbjct: 351 YTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDL 410
Query: 547 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 606
AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA
Sbjct: 411 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 470
Query: 607 SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 666
SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS
Sbjct: 471 SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESS 530
Query: 667 NVEILHVRKPEKYQLHLHESCVLSLKFASC 696
NVEILHVRKPEKYQLHLHESCVLSLKFASC
Sbjct: 531 NVEILHVRKPEKYQLHLHESCVLSLKFASC 560
>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
Length = 773
Score = 867 bits (2240), Expect = 0.0
Identities = 460/711 (64%), Positives = 543/711 (76%), Gaps = 38/711 (5%)
Query: 16 PASGLQTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM 75
P + P Q QPFKF+I E CDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM
Sbjct: 10 PQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVM 69
Query: 76 YYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLI 135
YYEMSYGLNIEMHKQAEIVKRL+ ICAQ+IPFL+QEHQQQV+QAVERAKQVT+ ELN++I
Sbjct: 70 YYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAII 129
Query: 136 GQQ-QLQPLSH-HAPPVPLTPRPAGLVG------GSATGLLALSGALAAQAQLAAAVKED 187
GQQ Q Q LSH H PVPLTP P+GL GS+ GLLALS AL Q+ L +K++
Sbjct: 130 GQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLP--IKDE 187
Query: 188 RAGVEAEGSRVERAPSRSASPSPPESL--VEEERPSGP--GGGGKQRADEKEPSGPYESD 243
+ + + R +R +S+S SP S E+ R S KQ+ +EKE + Y+SD
Sbjct: 188 KKHHDNDHQR-DRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSD 246
Query: 244 EDKSDYNLVVD---EDQPSEPPSPATTP----CGKVPICIPARRDLVDSPASLASSLGSP 296
+KSD NLVVD ED S SPA +P K + ++D SPAS+ASS +P
Sbjct: 247 GEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLL---KKDAPISPASIASSSSTP 303
Query: 297 LPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVA--LR 354
++KEL LN+ ++TP SKS +P DA TPG +S L + KP P D +A LR
Sbjct: 304 SSKSKELSLNE-KSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKP-PGVDPLASSLR 361
Query: 355 SPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSSVV-------YGRSPV 405
+P+ + P+ T F + H+ +NG+L+ P ++Y LH +SPQ+S++ YGRSPV
Sbjct: 362 TPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPV 421
Query: 406 MAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQL 465
+ F+ H H+R ++ +L IPGGKPAYSFHVSADGQMQPVPFP DAL+G GIPRHARQ+
Sbjct: 422 VGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQI 481
Query: 466 HTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 525
+TL HGEVVCAVTIS T+HVYTGGKGCVKVWD+ PG K+PV+QLDCLNRDNYIRSC+L
Sbjct: 482 NTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRL 541
Query: 526 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 585
LPDGR+LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCCSDGNI
Sbjct: 542 LPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNI 601
Query: 586 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSS 645
VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQHDF+S
Sbjct: 602 AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS 661
Query: 646 QIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696
QIFSLG+CP +WLAVGME+SNVE+LHV KP+KYQLHLHESCVLSLKFA C
Sbjct: 662 QIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHC 712
>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
Length = 770
Score = 861 bits (2225), Expect = 0.0
Identities = 466/714 (65%), Positives = 545/714 (76%), Gaps = 40/714 (5%)
Query: 16 PASGLQTPLQS-GQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV 74
P S TP Q+ GQPFKF+I E DRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV
Sbjct: 3 PQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV 62
Query: 75 MYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSL 134
MYYEMSYGLNIEMHKQ EI KRL+ ICAQ+IPFL+QEHQQQV QAVERAKQVT+ ELN++
Sbjct: 63 MYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAI 122
Query: 135 IGQQQLQP--LSH-HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAAAV 184
IGQQQLQ LSH H PPVPLTP P+GL +GGSA GLLALS AL+ Q+ LA +
Sbjct: 123 IGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSA-GLLALSSALSGQSHLA--I 179
Query: 185 KEDRAGVEAEGSRVERAPSRSASPSPPESLV-EEERPSGPGGGG---KQRADEKEPSGPY 240
K+D+ +AE R +R P S S P+SL ++R +GP K++ D+K+ S Y
Sbjct: 180 KDDKKHHDAEHHR-DREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKD-SSHY 237
Query: 241 ESDEDKSDYNLVVD---EDQPSEPPSPATTPCGK-VPICIPARRDLVDSPASLASSLGSP 296
+SD DKSD NLVVD ED S SPA +P + ++D SPAS ASS S
Sbjct: 238 DSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASST 297
Query: 297 LPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTD------S 350
++KE+ L++ ASTP KS +P D TPG S+ L KP P+ D +
Sbjct: 298 SLKSKEMSLHE-KASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKP-PAIDPLVNQAA 355
Query: 351 VALRSPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSS------VVYGR 402
LR+PL + P+ F + H+ +NG+L+ P ++Y SLH +SPQ+S++ V YGR
Sbjct: 356 AGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGR 415
Query: 403 SPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHA 462
SP++ F+ PH+R ++ +L IPGGKPAYSFHV+ADGQMQPVPFP DAL+G GIPRHA
Sbjct: 416 SPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHA 475
Query: 463 RQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRS 522
RQ++TL HGEVVCAVTIS T+HVYTGGKGCVKVWD+ PG K+PV+QLDCLNRDNYIRS
Sbjct: 476 RQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRS 535
Query: 523 CKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSD 582
CKLLPDG +LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCCSD
Sbjct: 536 CKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD 595
Query: 583 GNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHD 642
GNI VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQHD
Sbjct: 596 GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHD 655
Query: 643 FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696
F+SQIFSLG+CP +WLAVGMESSNVE+LHV KP+KYQLHLHESCVLSLKFA C
Sbjct: 656 FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYC 709
>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
sapiens]
Length = 769
Score = 843 bits (2179), Expect = 0.0
Identities = 450/708 (63%), Positives = 535/708 (75%), Gaps = 43/708 (6%)
Query: 23 PLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 81
P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRHYVMYYEMSY
Sbjct: 10 PHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSY 69
Query: 82 GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQLQ 141
GLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN++IGQQQLQ
Sbjct: 70 GLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQ 129
Query: 142 P--LSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAAAVKEDRAG 190
LSH H PPV L P P+GL V GS++GLLAL GAL +QA L VK+++
Sbjct: 130 AQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT--VKDEKNH 186
Query: 191 VEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPSGPYESDEDK 246
E + ER S + S SP ESL E+ G K++A+EK+ Y+SD DK
Sbjct: 187 HELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDK 244
Query: 247 SDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASSLGSPLPRAK 301
SD +LVVD +P +P +P P ++D SPAS+ASS +P + K
Sbjct: 245 SD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTK 302
Query: 302 ELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVA--LRSPLTL 359
+L ND +STP KS +P DA TPG S+ L + KP P D +A LR+P+++
Sbjct: 303 DLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP-PGMDPIASALRTPISI 360
Query: 360 SSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YGRSPVMAF----- 408
+S + F++ SH +NG L+ P +Y LH + PQ+S++ YGRSP+++F
Sbjct: 361 TSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGF 420
Query: 409 ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTL 468
+ HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRHARQ++TL
Sbjct: 421 DPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTL 480
Query: 469 AHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 528
+HGEVVCAVTIS T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIRSCKLLPD
Sbjct: 481 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 540
Query: 529 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 588
GR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCSDGNI VW
Sbjct: 541 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 600
Query: 589 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIF 648
DL NQT+VRQFQGHTDGASCIDIS GT+LWTGGLDNTVR WDLREGRQLQQHDF+SQIF
Sbjct: 601 DLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIF 660
Query: 649 SLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696
SLG+CP +WLAVGMESSNVE+LH KP+KYQLHLHESCVLSLKFA C
Sbjct: 661 SLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYC 708
Score = 30.0 bits (66), Expect = 7.7
Identities = 29/148 (19%), Positives = 53/148 (35%), Gaps = 8/148 (5%)
Query: 528 DGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVV 587
DG L GG +T+ WDL + + TS ++L P + N+
Sbjct: 626 DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI---FSLGYCPTGEWLAVGMESSNV-- 680
Query: 588 WDLQNQTMVRQFQGHTDGASCIDISDYGTRLW--TGGLDNTVRCWDLREGRQLQQHDFSS 645
++ + T ++Q H + + + W + G DN + W G + Q SS
Sbjct: 681 -EVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS 739
Query: 646 QIFSLGHCPNQDWLAVGMESSNVEILHV 673
+ S + ++ G + V
Sbjct: 740 SVLSCDISADDKYIVTGSGDKKATVYEV 767
>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
sapiens]
Length = 772
Score = 842 bits (2176), Expect = 0.0
Identities = 450/711 (63%), Positives = 535/711 (75%), Gaps = 46/711 (6%)
Query: 23 PLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 81
P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRHYVMYYEMSY
Sbjct: 10 PHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSY 69
Query: 82 GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQLQ 141
GLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN++IGQQQLQ
Sbjct: 70 GLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQ 129
Query: 142 P--LSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAAAVKEDRAG 190
LSH H PPV L P P+GL V GS++GLLAL GAL +QA L VK+++
Sbjct: 130 AQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT--VKDEKNH 186
Query: 191 VEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPSGPYESDEDK 246
E + ER S + S SP ESL E+ G K++A+EK+ Y+SD DK
Sbjct: 187 HELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDK 244
Query: 247 SDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASSLGSPLPRAK 301
SD +LVVD +P +P +P P ++D SPAS+ASS +P + K
Sbjct: 245 SD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTK 302
Query: 302 ELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSV-----ALRSP 356
+L ND +STP KS +P DA TPG S+ L + KP P D + ALR+P
Sbjct: 303 DLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKP-PGMDPIGIMASALRTP 360
Query: 357 LTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YGRSPVMAF-- 408
++++S + F++ SH +NG L+ P +Y LH + PQ+S++ YGRSP+++F
Sbjct: 361 ISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGA 420
Query: 409 ---ESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQL 465
+ HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRHARQ+
Sbjct: 421 VGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQI 480
Query: 466 HTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 525
+TL+HGEVVCAVTIS T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIRSCKL
Sbjct: 481 NTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKL 540
Query: 526 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 585
LPDGR+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCSDGNI
Sbjct: 541 LPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNI 600
Query: 586 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSS 645
VWDL NQT+VRQFQGHTDGASCIDIS GT+LWTGGLDNTVR WDLREGRQLQQHDF+S
Sbjct: 601 AVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS 660
Query: 646 QIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696
QIFSLG+CP +WLAVGMESSNVE+LH KP+KYQLHLHESCVLSLKFA C
Sbjct: 661 QIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYC 711
Score = 30.0 bits (66), Expect = 7.7
Identities = 29/148 (19%), Positives = 53/148 (35%), Gaps = 8/148 (5%)
Query: 528 DGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVV 587
DG L GG +T+ WDL + + TS ++L P + N+
Sbjct: 629 DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI---FSLGYCPTGEWLAVGMESSNV-- 683
Query: 588 WDLQNQTMVRQFQGHTDGASCIDISDYGTRLW--TGGLDNTVRCWDLREGRQLQQHDFSS 645
++ + T ++Q H + + + W + G DN + W G + Q SS
Sbjct: 684 -EVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS 742
Query: 646 QIFSLGHCPNQDWLAVGMESSNVEILHV 673
+ S + ++ G + V
Sbjct: 743 SVLSCDISADDKYIVTGSGDKKATVYEV 770
>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
sapiens]
Length = 760
Score = 837 bits (2163), Expect = 0.0
Identities = 447/706 (63%), Positives = 531/706 (75%), Gaps = 48/706 (6%)
Query: 23 PLQSGQP-FKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSY 81
P Q GQP FKF++ E CDRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRHYVMYYEMSY
Sbjct: 10 PHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSY 69
Query: 82 GLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQLQ 141
GLNIEMHKQ EI KRL+ I AQI+PFL+QEHQQQV QAVERAKQVT+ ELN++IGQQQLQ
Sbjct: 70 GLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQ 129
Query: 142 P--LSH--HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAAAVKEDRAG 190
LSH H PPV L P P+GL V GS++GLLAL GAL +QA L VK+++
Sbjct: 130 AQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLAL-GALGSQAHLT--VKDEKNH 186
Query: 191 VEAEGSRVERAPSRSASPSPPESLVEEERPSGPGG----GGKQRADEKEPSGPYESDEDK 246
E + ER S + S SP ESL E+ G K++A+EK+ Y+SD DK
Sbjct: 187 HELDHR--ERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDK 244
Query: 247 SDYNLVVDEDQPSEPPSPATTPCGKVPI-----CIPARRDLVDSPASLASSLGSPLPRAK 301
SD +LVVD +P +P +P P ++D SPAS+ASS +P + K
Sbjct: 245 SD-DLVVDVSN-EDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTK 302
Query: 302 ELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSS 361
+L ND +STP KS +P DA TPG S+ L + A ALR+P++++S
Sbjct: 303 DLGHND-KSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPAS--------ALRTPISITS 353
Query: 362 PFTTSFSLGSHSTLNGDLSVPSSYVSLH-LSPQVSSSVV-----YGRSPVMAF-----ES 410
+ F++ SH +NG L+ P +Y LH + PQ+S++ YGRSP+++F +
Sbjct: 354 SYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVSFGAVGFDP 413
Query: 411 HPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAH 470
HP +R + + SSL SIPGGKPAYSFHVSADGQMQPVPFP DAL G GIPRHARQ++TL+H
Sbjct: 414 HPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSH 473
Query: 471 GEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGR 530
GEVVCAVTIS T+HVYTGGKGCVK+WD+ QPG+K+P++QLDCLNRDNYIRSCKLLPDGR
Sbjct: 474 GEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGR 533
Query: 531 SLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDL 590
+LIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALA+SPDAKVCFSCCSDGNI VWDL
Sbjct: 534 TLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDL 593
Query: 591 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSL 650
NQT+VRQFQGHTDGASCIDIS GT+LWTGGLDNTVR WDLREGRQLQQHDF+SQIFSL
Sbjct: 594 HNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSL 653
Query: 651 GHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696
G+CP +WLAVGMESSNVE+LH KP+KYQLHLHESCVLSLKFA C
Sbjct: 654 GYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYC 699
Score = 30.0 bits (66), Expect = 7.7
Identities = 29/148 (19%), Positives = 53/148 (35%), Gaps = 8/148 (5%)
Query: 528 DGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVV 587
DG L GG +T+ WDL + + TS ++L P + N+
Sbjct: 617 DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI---FSLGYCPTGEWLAVGMESSNV-- 671
Query: 588 WDLQNQTMVRQFQGHTDGASCIDISDYGTRLW--TGGLDNTVRCWDLREGRQLQQHDFSS 645
++ + T ++Q H + + + W + G DN + W G + Q SS
Sbjct: 672 -EVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS 730
Query: 646 QIFSLGHCPNQDWLAVGMESSNVEILHV 673
+ S + ++ G + V
Sbjct: 731 SVLSCDISADDKYIVTGSGDKKATVYEV 758
>gi|39812027 amino-terminal enhancer of split isoform c [Homo
sapiens]
Length = 196
Score = 209 bits (531), Expect = 9e-54
Identities = 114/174 (65%), Positives = 134/174 (77%), Gaps = 11/174 (6%)
Query: 28 QPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEM 87
Q KF+ + CDRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRHYVMYYEMSYGLNIEM
Sbjct: 16 QQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEM 75
Query: 88 HKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQQLQPLSH-H 146
HKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT ELNS+I Q Q LS
Sbjct: 76 HKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQLQAHQLSQLQ 135
Query: 147 APPVPLTPRPAGL------VGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAE 194
A +PLTP P GL + TGLL+LS AL +QA L+ KED+ G + +
Sbjct: 136 ALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS---KEDKNGHDGD 185
>gi|39812019 amino-terminal enhancer of split isoform a [Homo
sapiens]
Length = 264
Score = 207 bits (526), Expect = 4e-53
Identities = 115/175 (65%), Positives = 135/175 (77%), Gaps = 12/175 (6%)
Query: 28 QPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEM 87
Q KF+ + CDRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRHYVMYYEMSYGLNIEM
Sbjct: 83 QQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEM 142
Query: 88 HKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQ-QLQPLSH- 145
HKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT ELNS+I QQ Q LS
Sbjct: 143 HKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQL 202
Query: 146 HAPPVPLTPRPAGL------VGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAE 194
A +PLTP P GL + TGLL+LS AL +QA L+ KED+ G + +
Sbjct: 203 QALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS---KEDKNGHDGD 253
>gi|5706731 amino-terminal enhancer of split isoform b [Homo
sapiens]
Length = 197
Score = 207 bits (526), Expect = 4e-53
Identities = 115/175 (65%), Positives = 135/175 (77%), Gaps = 12/175 (6%)
Query: 28 QPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEM 87
Q KF+ + CDRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRHYVMYYEMSYGLNIEM
Sbjct: 16 QQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEM 75
Query: 88 HKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQ-QLQPLSH- 145
HKQAEIVKRL+GICAQ++P+L+QEHQQQVL A+ERAKQVT ELNS+I QQ Q LS
Sbjct: 76 HKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQL 135
Query: 146 HAPPVPLTPRPAGL------VGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAE 194
A +PLTP P GL + TGLL+LS AL +QA L+ KED+ G + +
Sbjct: 136 QALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS---KEDKNGHDGD 186
>gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo
sapiens]
Length = 572
Score = 162 bits (411), Expect = 8e-40
Identities = 88/251 (35%), Positives = 143/251 (56%), Gaps = 9/251 (3%)
Query: 451 DALVGAG----IPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDV-GQPGA- 504
DAL G +P ++ LAHGE+V A IS T+HV+T G+ +KVW + GQ
Sbjct: 262 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 321
Query: 505 KTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGG-EASTLSIWDLAAPTPRIKAELTSSAPA 563
+ P + L ++R+C L + RSL+ GG +++S+WDLAAP+ +K +L +
Sbjct: 322 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 381
Query: 564 CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 623
C AL + DA + F+ + G + +WDL++Q++VR +G+ DG I + Y +WTGG
Sbjct: 382 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGGP 439
Query: 624 DNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL 683
D +RCWD R + ++ F SQI SL H P +DW+ +GM + + +++ +
Sbjct: 440 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 499
Query: 684 HESCVLSLKFA 694
+S +LS+KF+
Sbjct: 500 KDSVILSVKFS 510
>gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo
sapiens]
Length = 449
Score = 162 bits (411), Expect = 8e-40
Identities = 88/251 (35%), Positives = 143/251 (56%), Gaps = 9/251 (3%)
Query: 451 DALVGAG----IPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDV-GQPGA- 504
DAL G +P ++ LAHGE+V A IS T+HV+T G+ +KVW + GQ
Sbjct: 139 DALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAED 198
Query: 505 KTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGG-EASTLSIWDLAAPTPRIKAELTSSAPA 563
+ P + L ++R+C L + RSL+ GG +++S+WDLAAP+ +K +L +
Sbjct: 199 RFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGLN 258
Query: 564 CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGL 623
C AL + DA + F+ + G + +WDL++Q++VR +G+ DG I + Y +WTGG
Sbjct: 259 CQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGGP 316
Query: 624 DNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHL 683
D +RCWD R + ++ F SQI SL H P +DW+ +GM + + +++ +
Sbjct: 317 DACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVGQ 376
Query: 684 HESCVLSLKFA 694
+S +LS+KF+
Sbjct: 377 KDSVILSVKFS 387
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 74.7 bits (182), Expect = 3e-13
Identities = 55/236 (23%), Positives = 97/236 (41%), Gaps = 10/236 (4%)
Query: 462 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 520
+R H + V V S S + +G + V++W G T +
Sbjct: 14 SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 68
Query: 521 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 580
RS DG+S + + T+ +W A + L+ SPD ++ S
Sbjct: 69 RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 126
Query: 581 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 640
D + +WD ++ V + H + +D GT + G+DNTV+ WD+R R LQ
Sbjct: 127 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186
Query: 641 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFA 694
+ S+ + L P+ ++L S ++IL + + Y LH H+ ++ F+
Sbjct: 187 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 242
Score = 44.7 bits (104), Expect = 3e-04
Identities = 55/264 (20%), Positives = 90/264 (34%), Gaps = 34/264 (12%)
Query: 389 HLSPQVSSSVVYGRSPVMA---FESHPHL-----RGSSVSSSLPSIPGGKPAY------- 433
H+ PQ + G + F HL R +V +P++ G +
Sbjct: 9 HMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATV 68
Query: 434 -SFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAH--GEVVCAVTISGSTQHVYTGG 490
S H +DGQ V D V + L +L+ V CA V
Sbjct: 69 RSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 127
Query: 491 KGCVKVWDVGQPGAKTPVAQLDCLN----RDNYIRSCKLLPDGRSLIVGGEASTLSIWDL 546
VK+WD + +C++ ++ P G + G +T+ +WD+
Sbjct: 128 DKTVKLWDK---------SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Query: 547 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 606
T R+ + A L+ P + SD + + DL ++ GH A
Sbjct: 179 R--THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPA 236
Query: 607 SCIDISDYGTRLWTGGLDNTVRCW 630
+ + S G +GG D V W
Sbjct: 237 TTVAFSRTGEYFASGGSDEQVMVW 260
Score = 43.9 bits (102), Expect = 5e-04
Identities = 18/49 (36%), Positives = 28/49 (57%)
Query: 582 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCW 630
D ++VW ++ Q+ +F GH D +C++ S G L +G D TVR W
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 74.7 bits (182), Expect = 3e-13
Identities = 55/236 (23%), Positives = 97/236 (41%), Gaps = 10/236 (4%)
Query: 462 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 520
+R H + V V S S + +G + V++W G T +
Sbjct: 52 SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 106
Query: 521 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 580
RS DG+S + + T+ +W A + L+ SPD ++ S
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 581 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 640
D + +WD ++ V + H + +D GT + G+DNTV+ WD+R R LQ
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
Query: 641 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFA 694
+ S+ + L P+ ++L S ++IL + + Y LH H+ ++ F+
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 280
Score = 47.4 bits (111), Expect = 5e-05
Identities = 60/286 (20%), Positives = 100/286 (34%), Gaps = 36/286 (12%)
Query: 367 FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMA---FESHPHL-----RGSS 418
FS+ + +G S+ S + H+ PQ + G + F HL R +
Sbjct: 27 FSINTKQLASG--SMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84
Query: 419 VSSSLPSIPGGKPAY--------SFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAH 470
V +P++ G + S H +DGQ V D V + L +L+
Sbjct: 85 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFSLSQ 143
Query: 471 --GEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLN----RDNYIRSCK 524
V CA V VK+WD + +C++ ++
Sbjct: 144 HINWVRCAKFSPDGRLIVSASDDKTVKLWDK---------SSRECVHSYCEHGGFVTYVD 194
Query: 525 LLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGN 584
P G + G +T+ +WD+ T R+ + A L+ P + SD
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVR--THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 585 IVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCW 630
+ + DL ++ GH A+ + S G +GG D V W
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 46.2 bits (108), Expect = 1e-04
Identities = 24/83 (28%), Positives = 38/83 (45%)
Query: 548 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 607
A P ++ A + S + K S D ++VW ++ Q+ +F GH D +
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 608 CIDISDYGTRLWTGGLDNTVRCW 630
C++ S G L +G D TVR W
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIW 88
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/117 (23%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 591 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFS 649
++ ++ R F+GH D +C+D S +L +G +D+ + W ++ + R + +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 650 LGHCPNQDWLAVGMESSNVEI-LHVRKPEKYQLHLHESCVLSLKFASCVQGVVLSPE 705
+ P+ LA G V I + K E H + V S+ F S Q V + +
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 74.7 bits (182), Expect = 3e-13
Identities = 55/236 (23%), Positives = 97/236 (41%), Gaps = 10/236 (4%)
Query: 462 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNYI 520
+R H + V V S S + +G + V++W G T +
Sbjct: 52 SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTAT-----V 106
Query: 521 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 580
RS DG+S + + T+ +W A + L+ SPD ++ S
Sbjct: 107 RSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 581 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 640
D + +WD ++ V + H + +D GT + G+DNTV+ WD+R R LQ
Sbjct: 165 DDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224
Query: 641 HDF-SSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFA 694
+ S+ + L P+ ++L S ++IL + + Y LH H+ ++ F+
Sbjct: 225 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFS 280
Score = 47.4 bits (111), Expect = 5e-05
Identities = 60/286 (20%), Positives = 100/286 (34%), Gaps = 36/286 (12%)
Query: 367 FSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMA---FESHPHL-----RGSS 418
FS+ + +G S+ S + H+ PQ + G + F HL R +
Sbjct: 27 FSINTKQLASG--SMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKT 84
Query: 419 VSSSLPSIPGGKPAY--------SFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAH 470
V +P++ G + S H +DGQ V D V + L +L+
Sbjct: 85 VRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF-VTASDDKTVKVWATHRQKFLFSLSQ 143
Query: 471 --GEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLN----RDNYIRSCK 524
V CA V VK+WD + +C++ ++
Sbjct: 144 HINWVRCAKFSPDGRLIVSASDDKTVKLWDK---------SSRECVHSYCEHGGFVTYVD 194
Query: 525 LLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGN 584
P G + G +T+ +WD+ T R+ + A L+ P + SD
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVR--THRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 585 IVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCW 630
+ + DL ++ GH A+ + S G +GG D V W
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 46.2 bits (108), Expect = 1e-04
Identities = 24/83 (28%), Positives = 38/83 (45%)
Query: 548 APTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGAS 607
A P ++ A + S + K S D ++VW ++ Q+ +F GH D +
Sbjct: 6 AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65
Query: 608 CIDISDYGTRLWTGGLDNTVRCW 630
C++ S G L +G D TVR W
Sbjct: 66 CVNFSPSGHLLASGSRDKTVRIW 88
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/117 (23%), Positives = 52/117 (44%), Gaps = 2/117 (1%)
Query: 591 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLR-EGRQLQQHDFSSQIFS 649
++ ++ R F+GH D +C+D S +L +G +D+ + W ++ + R + +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 650 LGHCPNQDWLAVGMESSNVEI-LHVRKPEKYQLHLHESCVLSLKFASCVQGVVLSPE 705
+ P+ LA G V I + K E H + V S+ F S Q V + +
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 71.2 bits (173), Expect = 3e-12
Identities = 53/205 (25%), Positives = 84/205 (40%), Gaps = 11/205 (5%)
Query: 457 GIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLN 515
GIP+ A + H V V IS Q +G G +++WD+ T +
Sbjct: 53 GIPQRALR----GHSHFVSDVVISSDGQFALSGSWDGTLRLWDL-----TTGTTTRRFVG 103
Query: 516 RDNYIRSCKLLPDGRSLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAVSPDAK 574
+ S D R ++ G T+ +W+ L ++ E S +C + +
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163
Query: 575 VCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLRE 634
+ SC D + VW+L N + GHT + + +S G+ +GG D WDL E
Sbjct: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223
Query: 635 GRQLQQHDFSSQIFSLGHCPNQDWL 659
G+ L D I +L PN+ WL
Sbjct: 224 GKHLYTLDGGDIINALCFSPNRYWL 248
Score = 44.3 bits (103), Expect = 4e-04
Identities = 45/180 (25%), Positives = 72/180 (40%), Gaps = 23/180 (12%)
Query: 469 AHGEVVCAVTISGSTQH---VYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 525
+H E V V S ++ + V G VKVW++ KT + + Y+ + +
Sbjct: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT-----NHIGHTGYLNTVTV 200
Query: 526 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDG-N 584
PDG GG+ +WDL + AL SP+ + C + G +
Sbjct: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLD---GGDIINALCFSPNRY--WLCAATGPS 255
Query: 585 IVVWDLQNQTMVRQFQGHTDGAS-------CIDI--SDYGTRLWTGGLDNTVRCWDLREG 635
I +WDL+ + +V + + S C + S G L+ G DN VR W + G
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 68.9 bits (167), Expect = 1e-11
Identities = 55/237 (23%), Positives = 96/237 (40%), Gaps = 10/237 (4%)
Query: 461 HARQLHTLAHGEVVCAVTISGSTQHVYTGGKG-CVKVWDVGQPGAKTPVAQLDCLNRDNY 519
HAR + H +VV +V S + + + V++W + G +
Sbjct: 50 HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKA-----HTAP 104
Query: 520 IRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSC 579
+RS DG+ L E ++ +W + R L SPD ++ SC
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQ--RFLYSLYRHTHWVRCAKFSPDGRLIVSC 162
Query: 580 CSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 639
D I +WD N+ V F A+ +D + GT + + G D TV+ WD+R + LQ
Sbjct: 163 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222
Query: 640 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEK-YQLHLHESCVLSLKFA 694
+ S + + P+ ++L ++IL + + Y L H V ++ F+
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFS 279
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/150 (21%), Positives = 66/150 (44%), Gaps = 2/150 (1%)
Query: 547 AAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGA 606
A P ++ A +L +SP+ K + D +++W+ + ++ GH D
Sbjct: 4 ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63
Query: 607 SCIDISDYGTRLWTGGLDNTVRCW-DLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMES 665
+ + S +G L + D TVR W + G+ + ++ + S+ + +LA E
Sbjct: 64 TSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASED 123
Query: 666 SNVEILHV-RKPEKYQLHLHESCVLSLKFA 694
++++ + R+ Y L+ H V KF+
Sbjct: 124 KSIKVWSMYRQRFLYSLYRHTHWVRCAKFS 153
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/137 (21%), Positives = 51/137 (37%), Gaps = 7/137 (5%)
Query: 494 VKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRI 553
+K+WD + D + N++ P G + G T+ +WD+
Sbjct: 168 IKIWDTTNKQCVNNFS--DSVGFANFV---DFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222
Query: 554 KAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISD 613
++ S C ++ P + SDG + + DL ++ QGHT + S
Sbjct: 223 HYQVHSGGVNC--ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSK 280
Query: 614 YGTRLWTGGLDNTVRCW 630
G +GG D V W
Sbjct: 281 GGELFASGGADTQVLLW 297
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 68.2 bits (165), Expect = 3e-11
Identities = 53/235 (22%), Positives = 101/235 (42%), Gaps = 25/235 (10%)
Query: 468 LAHGEVVCAVTIS-GSTQHVYTGGKGC-VKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 525
+AH V ++ + S + + TGG C V +W + +P + + + S +L
Sbjct: 17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCI-----MSLTGHTSPVESVRL 71
Query: 526 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 585
++ G ++ ++ +WDL A +I L +L P + S D NI
Sbjct: 72 NTPEELIVAGSQSGSIRVWDLEAA--KILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129
Query: 586 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH-DFS 644
+WD++ + V +++GH+ C+ S G L + D+TV+ WDL G+ + + +
Sbjct: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
Query: 645 SQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCVQG 699
+ + PN+ LA G + + EK+Q+ SC++G
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDL---EKFQV------------VSCIEG 229
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 66.2 bits (160), Expect = 1e-10
Identities = 42/169 (24%), Positives = 73/169 (43%), Gaps = 14/169 (8%)
Query: 472 EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRS 531
+V C V +G G +K+W+V +T + L+ + +R P G
Sbjct: 120 DVSCLVLATGLND-------GQIKIWEV-----QTGLLLLNLSGHQDVVRDLSFTPSGSL 167
Query: 532 LIVGGEAS-TLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDL 590
++V TL IWDL +I+ L+ Y ++SPD + S + ++ +W +
Sbjct: 168 ILVSASRDKTLRIWDLNKHGKQIQV-LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSM 226
Query: 591 QNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 639
++ T++R+ +GH D S L T D V WD G +L+
Sbjct: 227 RSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLR 275
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 65.9 bits (159), Expect = 1e-10
Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 19/230 (8%)
Query: 470 HG-EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 528
HG +V+C + V + G V VWD + V + C ++ +C P
Sbjct: 62 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVT-MPC----TWVMACAYAPS 116
Query: 529 GRSLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 581
G ++ GG + S++ L A + A T+ AC + D ++ +
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--TNSDMQI-LTASG 173
Query: 582 DGNIVVWDLQNQTMVRQFQGHTDGASCIDI--SDYGTRLWTGGLDNTVRCWDLREGRQLQ 639
DG +WD+++ +++ F GH C+D+ S+ G +GG D WD+R G+ +Q
Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233
Query: 640 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCV 688
+ S I S+ + P+ D A G + + + +R + ++ ES +
Sbjct: 234 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESII 283
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/165 (25%), Positives = 71/165 (43%), Gaps = 10/165 (6%)
Query: 470 HG-EVVCAVTISGSTQHVYTGGKGCVK---VWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 525
HG +V+C T + + G GC K VWD+ + G + ++ I S +
Sbjct: 194 HGADVLCLDLAPSETGNTFVSG-GCDKKAMVWDM-RSGQCVQAFE----THESDINSVRY 247
Query: 526 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 585
P G + G + +T ++DL A S ++ S ++ F+ +D I
Sbjct: 248 YPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTI 307
Query: 586 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCW 630
VWD+ + V GH + S + +S GT +G D+T+R W
Sbjct: 308 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 35.0 bits (79), Expect = 0.24
Identities = 31/165 (18%), Positives = 53/165 (32%), Gaps = 44/165 (26%)
Query: 518 NYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCF 577
NY+ +C ++ T ++WD+ + + C LA S
Sbjct: 154 NYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFV 213
Query: 578 SCCSDGNIVVWDLQNQTMVRQFQGHTD--------------------------------- 604
S D +VWD+++ V+ F+ H
Sbjct: 214 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADRE 273
Query: 605 -----------GASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL 638
GAS +D S G L+ G D T+ WD+ +G ++
Sbjct: 274 VAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 318
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 65.9 bits (159), Expect = 1e-10
Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 19/230 (8%)
Query: 470 HG-EVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 528
HG +V+C + V + G V VWD + V + C ++ +C P
Sbjct: 104 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVT-MPC----TWVMACAYAPS 158
Query: 529 GRSLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 581
G ++ GG + S++ L A + A T+ AC + D ++ +
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF--TNSDMQI-LTASG 215
Query: 582 DGNIVVWDLQNQTMVRQFQGHTDGASCIDI--SDYGTRLWTGGLDNTVRCWDLREGRQLQ 639
DG +WD+++ +++ F GH C+D+ S+ G +GG D WD+R G+ +Q
Sbjct: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 275
Query: 640 QHD-FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCV 688
+ S I S+ + P+ D A G + + + +R + ++ ES +
Sbjct: 276 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESII 325
Score = 49.7 bits (117), Expect = 9e-06
Identities = 42/165 (25%), Positives = 71/165 (43%), Gaps = 10/165 (6%)
Query: 470 HG-EVVCAVTISGSTQHVYTGGKGCVK---VWDVGQPGAKTPVAQLDCLNRDNYIRSCKL 525
HG +V+C T + + G GC K VWD+ + G + ++ I S +
Sbjct: 236 HGADVLCLDLAPSETGNTFVSG-GCDKKAMVWDM-RSGQCVQAFE----THESDINSVRY 289
Query: 526 LPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 585
P G + G + +T ++DL A S ++ S ++ F+ +D I
Sbjct: 290 YPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTI 349
Query: 586 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCW 630
VWD+ + V GH + S + +S GT +G D+T+R W
Sbjct: 350 NVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 35.0 bits (79), Expect = 0.24
Identities = 31/165 (18%), Positives = 53/165 (32%), Gaps = 44/165 (26%)
Query: 518 NYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCF 577
NY+ +C ++ T ++WD+ + + C LA S
Sbjct: 196 NYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFV 255
Query: 578 SCCSDGNIVVWDLQNQTMVRQFQGHTD--------------------------------- 604
S D +VWD+++ V+ F+ H
Sbjct: 256 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADRE 315
Query: 605 -----------GASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL 638
GAS +D S G L+ G D T+ WD+ +G ++
Sbjct: 316 VAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRV 360
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 64.7 bits (156), Expect = 3e-10
Identities = 42/150 (28%), Positives = 64/150 (42%), Gaps = 7/150 (4%)
Query: 492 GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEAS-TLSIWDLAAPT 550
G +K+WDV T L+ ++ +R PDG ++V TL +WDL
Sbjct: 150 GRIKIWDV-----YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204
Query: 551 PRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCID 610
+K L Y+ A SPD+ + S + + +W++ TM+R+ +GH D
Sbjct: 205 NMMKV-LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACD 263
Query: 611 ISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 640
S G L T D V WD G L +
Sbjct: 264 FSPDGALLATASYDTRVYIWDPHNGDILME 293
Score = 42.4 bits (98), Expect = 0.001
Identities = 36/140 (25%), Positives = 58/140 (41%), Gaps = 9/140 (6%)
Query: 465 LHTLAHGEVVCAVTIS--GSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRS 522
L+ + H EVV +T + GS V ++VWD+ G V + N++ S
Sbjct: 164 LNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR----GHQNWVYS 219
Query: 523 CKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSD 582
C PD L G + + +W++ T K E A SPD + + D
Sbjct: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE--GHHHDVVACDFSPDGALLATASYD 277
Query: 583 GNIVVWDLQNQTMVRQFQGH 602
+ +WD N ++ +F GH
Sbjct: 278 TRVYIWDPHNGDILMEF-GH 296
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 63.9 bits (154), Expect = 5e-10
Identities = 62/235 (26%), Positives = 94/235 (40%), Gaps = 22/235 (9%)
Query: 470 HGEVVCAVTISGSTQHVYTGGK-GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 528
HG V + S Q + TG + GCV W+ + ++ C+ PD
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLG-----GHTGPVKFCRFSPD 74
Query: 529 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 588
G T+ +WD+A + L + ++ SPD++ S D +++W
Sbjct: 75 GHLFASASCDCTVRLWDVARA--KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
Query: 589 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIF 648
D+Q+ M+R GH D D S L TG D+TV WDLR H
Sbjct: 133 DVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE--- 189
Query: 649 SLGHCPNQDWL---AVGMESSNV--EILHVRKPEK----YQLHLHESCVLSLKFA 694
GH N L A G+ +S + +H+ KP QL H + V S+ F+
Sbjct: 190 --GHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFS 242
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/171 (26%), Positives = 71/171 (41%), Gaps = 6/171 (3%)
Query: 470 HGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 528
H V V+ S ++ + +GG V +WDV Q G + +L +RD+ I+S P
Sbjct: 104 HQRSVETVSFSPDSRQLASGGWDKRVMLWDV-QSGQ---MLRLLVGHRDS-IQSSDFSPT 158
Query: 529 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 588
L G ST+ IWDL TP + + A + + + S D I +W
Sbjct: 159 VNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIW 218
Query: 589 DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQ 639
+++ Q +GH I S L + G V+ WD G+ L+
Sbjct: 219 KPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 62.8 bits (151), Expect = 1e-09
Identities = 56/236 (23%), Positives = 99/236 (41%), Gaps = 12/236 (5%)
Query: 463 RQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLN-RDNYIR 521
RQ H L G A + G+ Q T G + G P + A + L+ + +
Sbjct: 19 RQRHELLLG----AGSGPGAGQQQATPGA----LLQAGPPRCSSLQAPIMLLSGHEGEVY 70
Query: 522 SCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 581
CK P+G +L G + +W++ A L + A L + D + FS +
Sbjct: 71 CCKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAVMELHYNTDGSMLFSAST 129
Query: 582 DGNIVVWDLQNQTMVRQFQGHTDGA-SCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 640
D + VWD + V++ +GHT SC + TG D TV+ WD+R+ +Q
Sbjct: 130 DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT 189
Query: 641 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPE-KYQLHLHESCVLSLKFAS 695
+ Q+ ++ D + G +++++ +R+ + Y + H V L +S
Sbjct: 190 FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS 245
Score = 58.2 bits (139), Expect = 3e-08
Identities = 40/157 (25%), Positives = 69/157 (43%), Gaps = 17/157 (10%)
Query: 518 NYIRSCKLLPDGRSLI-VGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVS--PDAK 574
+++ SC G L+ G + T+ +WD+ R KA + + LAV+ +
Sbjct: 152 SFVNSCYPARRGPQLVCTGSDDGTVKLWDI-----RKKAAIQTFQNTYQVLAVTFNDTSD 206
Query: 575 VCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLRE 634
S D +I VWDL+ + +GH D + + +S G+ L + +DNTVR WD+R
Sbjct: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP 266
Query: 635 GRQLQQ---------HDFSSQIFSLGHCPNQDWLAVG 662
++ H+F + P+ +A G
Sbjct: 267 FAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAG 303
Score = 35.4 bits (80), Expect = 0.18
Identities = 29/150 (19%), Positives = 60/150 (40%), Gaps = 12/150 (8%)
Query: 460 RHARQLHTLAHGEVVCAVTISGSTQHVYTGG-KGCVKVWDVGQPGAKTPVAQLDCLNRDN 518
R + T + V AVT + ++ + +GG +KVWD+ Q + +
Sbjct: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR-----GHAD 236
Query: 519 YIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPR------IKAELTSSAPACYALAVSPD 572
+ L +G L+ +T+ +WD+ P+ + + + + SPD
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
Query: 573 AKVCFSCCSDGNIVVWDLQNQTMVRQFQGH 602
+ +D + VWD ++ ++ + GH
Sbjct: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGH 326
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 62.4 bits (150), Expect = 1e-09
Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 5/138 (3%)
Query: 527 PDGRSLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNI 585
P+ + G T+ +WD L RI T ++L SP+ + + +DG +
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRI---FTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 586 VVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWD-LREGRQLQQHDFS 644
++WD+ + MV + +GHTD + S G L +G +DNTVR WD ++ L+ DF+
Sbjct: 694 LLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFT 753
Query: 645 SQIFSLGHCPNQDWLAVG 662
+ + N L +G
Sbjct: 754 TATGHINLPENSQELLLG 771
Score = 44.7 bits (104), Expect = 3e-04
Identities = 51/207 (24%), Positives = 74/207 (35%), Gaps = 48/207 (23%)
Query: 528 DGRSLIVGGEA-STLSIWDLAAPT---------------------PRIKAELTSS----- 560
D SLI GG A ST+ +W + RI E T+S
Sbjct: 480 DDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKIL 539
Query: 561 ---APACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTR 617
+ Y + SPD S DG + +W LQ T + ++GH S YG
Sbjct: 540 YGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYY 599
Query: 618 LWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHC---------PNQDWLAVGMESSNV 668
+GG D R W H +IF+ GH PN +++A G V
Sbjct: 600 FVSGGHDRVARLW-------ATDHYQPLRIFA-GHLADVNCTRFHPNSNYVATGSADRTV 651
Query: 669 EILHVRKPEKYQLHL-HESCVLSLKFA 694
+ V ++ H+ + SL F+
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTFS 678
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/160 (23%), Positives = 76/160 (47%), Gaps = 13/160 (8%)
Query: 490 GKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAP 549
GK VK DV + T +++ + +++ + PDG+ L+ G + +W+
Sbjct: 189 GKAAVK--DVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFT-- 244
Query: 550 TPRIKAELTSSA--------PACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQ- 600
T +I+ +L A A + S D ++ + DG I VW +Q+ +R+F+
Sbjct: 245 TGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFER 304
Query: 601 GHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 640
H+ G +C+ S +++ + D T+R L+ G+ L++
Sbjct: 305 AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKE 344
Score = 32.3 bits (72), Expect = 1.5
Identities = 35/154 (22%), Positives = 57/154 (37%), Gaps = 18/154 (11%)
Query: 525 LLPDGRSL-IVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDG 583
LLP G ++ + G+A+ + + PT + SPD + + DG
Sbjct: 177 LLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDG 236
Query: 584 NIVVW---------DLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLRE 634
I VW DL+ Q F D C+ S L TG D ++ W ++
Sbjct: 237 FIEVWNFTTGKIRKDLKYQAQ-DNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQS 295
Query: 635 GRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNV 668
G+ L++ F H L+ +SS +
Sbjct: 296 GQCLRR-------FERAHSKGVTCLSFSKDSSQI 322
>gi|31543297 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 1 [Homo sapiens]
Length = 917
Score = 60.5 bits (145), Expect = 5e-09
Identities = 49/204 (24%), Positives = 88/204 (43%), Gaps = 21/204 (10%)
Query: 440 DGQMQPVPFPSDALVGAGIP--------RHARQLHTLAHGEVVCAVTISGSTQHVYTGGK 491
D ++ + S V +G+P H L L H V ++++ ++ + +G K
Sbjct: 724 DNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTK 783
Query: 492 -GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPT 550
G V +WD+ T + Q+ C + PD R ++ G L++ D+ T
Sbjct: 784 EGTVNIWDLT---TATLMHQIPC--HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQ--T 836
Query: 551 PRIKAELTSSAPA-CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCI 609
+ + +TS P C+ D S G ++VWDL + + QGHT +CI
Sbjct: 837 GMLISSMTSDEPQRCFVW----DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCI 892
Query: 610 DISDYGTRLWTGGLDNTVRCWDLR 633
+++ + + TGG D + W L+
Sbjct: 893 WMNEQCSSIITGGEDRQIIFWKLQ 916
>gi|221625547 neutral sphingomyelinase (N-SMase) activation
associated factor isoform 2 [Homo sapiens]
Length = 948
Score = 60.5 bits (145), Expect = 5e-09
Identities = 49/204 (24%), Positives = 88/204 (43%), Gaps = 21/204 (10%)
Query: 440 DGQMQPVPFPSDALVGAGIP--------RHARQLHTLAHGEVVCAVTISGSTQHVYTGGK 491
D ++ + S V +G+P H L L H V ++++ ++ + +G K
Sbjct: 755 DNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTK 814
Query: 492 -GCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPT 550
G V +WD+ T + Q+ C + PD R ++ G L++ D+ T
Sbjct: 815 EGTVNIWDLT---TATLMHQIPC--HSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQ--T 867
Query: 551 PRIKAELTSSAPA-CYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCI 609
+ + +TS P C+ D S G ++VWDL + + QGHT +CI
Sbjct: 868 GMLISSMTSDEPQRCFVW----DGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCI 923
Query: 610 DISDYGTRLWTGGLDNTVRCWDLR 633
+++ + + TGG D + W L+
Sbjct: 924 WMNEQCSSIITGGEDRQIIFWKLQ 947
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 60.1 bits (144), Expect = 7e-09
Identities = 45/183 (24%), Positives = 77/183 (42%), Gaps = 20/183 (10%)
Query: 470 HGEVVCAVTISGSTQHVYTG-GKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 528
H E V +V S + +++ +G G V+ WD+ T C +++ S PD
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFWDLS-----TETPHFTCKGHRHWVLSISWSPD 167
Query: 529 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVS-------PDAKVCFSCCS 581
GR L G + + +WD P+ + T + + + +S P+ + S
Sbjct: 168 GRKLASGCKNGQILLWD---PSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 582 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREG---RQL 638
DG++ +WD R GHT +C+ G L++ D T++ W +G R L
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAHDGVLCRTL 283
Query: 639 QQH 641
Q H
Sbjct: 284 QGH 286
Score = 59.7 bits (143), Expect = 9e-09
Identities = 32/104 (30%), Positives = 49/104 (47%), Gaps = 2/104 (1%)
Query: 527 PDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIV 586
PD R + ++ +WD T + A L A Y +A S D+++ S SD +
Sbjct: 382 PDSRIVASASFDKSIKLWD--GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLK 439
Query: 587 VWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCW 630
VWD++ Q + GH D +D S G R+ +GG D +R W
Sbjct: 440 VWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 41.2 bits (95), Expect = 0.003
Identities = 28/132 (21%), Positives = 58/132 (43%), Gaps = 2/132 (1%)
Query: 532 LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQ 591
L+ G + TL +W A + +T + SPD+++ S D +I +WD +
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPL-TRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGR 402
Query: 592 NQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGR-QLQQHDFSSQIFSL 650
+ +GH I S L +G D+T++ WD++ + + + +++++
Sbjct: 403 TGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAV 462
Query: 651 GHCPNQDWLAVG 662
P+ +A G
Sbjct: 463 DWSPDGQRVASG 474
Score = 38.9 bits (89), Expect = 0.017
Identities = 24/87 (27%), Positives = 37/87 (42%)
Query: 552 RIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDI 611
R + L + A ++A SP K S D + WDL +T +GH I
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 612 SDYGTRLWTGGLDNTVRCWDLREGRQL 638
S G +L +G + + WD G+Q+
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQV 191
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,096,335
Number of Sequences: 37866
Number of extensions: 1821677
Number of successful extensions: 10911
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 189
Number of HSP's successfully gapped in prelim test: 711
Number of HSP's that attempted gapping in prelim test: 8369
Number of HSP's gapped (non-prelim): 2683
length of query: 706
length of database: 18,247,518
effective HSP length: 109
effective length of query: 597
effective length of database: 14,120,124
effective search space: 8429714028
effective search space used: 8429714028
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.