Guide to the Human Genome
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Search of human proteins with 221219000

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
         (1127 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]         2279   0.0  
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]         2026   0.0  
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]         1410   0.0  
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]         1374   0.0  
gi|14249340 phospholipase C, delta 4 [Homo sapiens]                   509   e-144
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]         484   e-136
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]        484   e-136
gi|19115964 phospholipase C delta 3 [Homo sapiens]                    452   e-127
gi|25188201 phospholipase C, zeta 1 [Homo sapiens]                    441   e-123
gi|78499633 phospholipase C, eta 2 [Homo sapiens]                     380   e-105
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]           344   3e-94
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]           344   3e-94
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]            340   3e-93
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]           336   8e-92
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]           336   8e-92
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso...   326   9e-89
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso...   326   9e-89
gi|95147333 phospholipase C, beta 2 [Homo sapiens]                    305   2e-82
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]         218   3e-56
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]         218   3e-56
gi|117320537 phospholipase C, gamma 2 [Homo sapiens]                  213   1e-54
gi|11386139 phospholipase C beta 3 [Homo sapiens]                     181   3e-45
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]                170   6e-42
gi|223633890 hypothetical protein LOC729956 [Homo sapiens]             47   1e-04
gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens]       44   9e-04
gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens]     42   0.004
gi|55956899 keratin 9 [Homo sapiens]                                   41   0.006
gi|21361472 neural precursor cell expressed, developmentally dow...    41   0.007
gi|222352090 neural precursor cell expressed, developmentally do...    41   0.007
gi|222352088 neural precursor cell expressed, developmentally do...    41   0.007

>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
          Length = 1127

 Score = 2279 bits (5905), Expect = 0.0
 Identities = 1127/1127 (100%), Positives = 1127/1127 (100%)

Query: 1    MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS 60
            MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS
Sbjct: 1    MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS 60

Query: 61   LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK 120
            LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK
Sbjct: 61   LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK 120

Query: 121  TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD 180
            TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD
Sbjct: 121  TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD 180

Query: 181  SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN 240
            SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN
Sbjct: 181  SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN 240

Query: 241  IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN 300
            IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN
Sbjct: 241  IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN 300

Query: 301  PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT 360
            PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT
Sbjct: 301  PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT 360

Query: 361  KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 420
            KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE
Sbjct: 361  KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 420

Query: 421  HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 480
            HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN
Sbjct: 421  HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 480

Query: 481  EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG 540
            EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG
Sbjct: 481  EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG 540

Query: 541  DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN 600
            DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN
Sbjct: 541  DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN 600

Query: 601  MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN 660
            MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN
Sbjct: 601  MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN 660

Query: 661  PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ 720
            PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ
Sbjct: 661  PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ 720

Query: 721  NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD 780
            NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD
Sbjct: 721  NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD 780

Query: 781  PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE 840
            PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE
Sbjct: 781  PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE 840

Query: 841  FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK 900
            FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK
Sbjct: 841  FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK 900

Query: 901  KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM 960
            KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM
Sbjct: 901  KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM 960

Query: 961  LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA 1020
            LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA
Sbjct: 961  LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA 1020

Query: 1021 VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE 1080
            VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE
Sbjct: 1021 VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE 1080

Query: 1081 TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1127
            TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE
Sbjct: 1081 TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1127


>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
          Length = 1001

 Score = 2026 bits (5248), Expect = 0.0
 Identities = 1001/1001 (100%), Positives = 1001/1001 (100%)

Query: 127  MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 186
            MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI
Sbjct: 1    MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60

Query: 187  DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 246
            DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL
Sbjct: 61   DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120

Query: 247  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 306
            RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS
Sbjct: 121  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180

Query: 307  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 366
            KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF
Sbjct: 181  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240

Query: 367  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 426
            LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ
Sbjct: 241  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300

Query: 427  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 486
            DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT
Sbjct: 301  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360

Query: 487  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 546
            GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT
Sbjct: 361  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420

Query: 547  SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 606
            SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN
Sbjct: 421  SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 480

Query: 607  VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 666
            VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN
Sbjct: 481  VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 540

Query: 667  YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 726
            YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY
Sbjct: 541  YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 600

Query: 727  VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 786
            VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE
Sbjct: 601  VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 660

Query: 787  IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 846
            IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT
Sbjct: 661  IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 720

Query: 847  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 906
            IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA
Sbjct: 721  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 780

Query: 907  SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 966
            SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR
Sbjct: 781  SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 840

Query: 967  FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 1026
            FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV
Sbjct: 841  FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 900

Query: 1027 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 1086
            HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK
Sbjct: 901  HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 960

Query: 1087 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1127
            QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE
Sbjct: 961  QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1001


>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
          Length = 1095

 Score = 1410 bits (3649), Expect = 0.0
 Identities = 715/1125 (63%), Positives = 860/1125 (76%), Gaps = 46/1125 (4%)

Query: 8    GAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDE 67
            GAAG   P  P  A             GG    R+G   A         GDC    SG  
Sbjct: 4    GAAGREDPAPPDAA-------------GGEDDPRVGPDAA---------GDCVTAASGGR 41

Query: 68   ARASPTRGPRGVALAPTPSAVVCTLPRESKPGGL------PRRSSIIKDGTKQK-RERKK 120
             R   +    GVAL   P A     P +S+ G L      PRRSSIIKD + QK   RKK
Sbjct: 42   MRDRRS----GVAL---PGAA--GTPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKK 92

Query: 121  TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD 180
            TVSFSSMP+EKKISSA+DCI+ M  G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD
Sbjct: 93   TVSFSSMPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKD 152

Query: 181  SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN 240
             EKAK+DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVAN
Sbjct: 153  LEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVAN 212

Query: 241  IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN 300
            IWV+GLRYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +    +V+ I+ LN
Sbjct: 213  IWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLN 272

Query: 301  PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT 360
            P LK +KI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD 
Sbjct: 273  PTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDA 332

Query: 361  KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 420
             DLM+FLEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE
Sbjct: 333  NDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPE 392

Query: 421  HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 480
             KKV QDM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DN
Sbjct: 393  QKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDN 452

Query: 481  EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG 540
            EP++   + MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G
Sbjct: 453  EPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFG 512

Query: 541  DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE- 599
            +KLYT +P   ESYLPSP+ LK  I++K KKL S+   +EG+VTDEDE AEMS+RM  + 
Sbjct: 513  NKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDY 572

Query: 600  NMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANE 659
            N EQ      K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E  AS+ ANE
Sbjct: 573  NGEQ------KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANE 626

Query: 660  NPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFR 719
             P DFVNYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF 
Sbjct: 627  YPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFL 686

Query: 720  QNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVV 779
            QNG CGYVLRP+IMR+EVS+FSANTK  +PGVSP  LHIKIISGQNFPKPKG+ AKGDV+
Sbjct: 687  QNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVI 746

Query: 780  DPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGD 839
            DPYV +EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGD
Sbjct: 747  DPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGD 806

Query: 840  EFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKG 899
            EFIGQYTIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GGGK  KR LSVR G
Sbjct: 807  EFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMG 866

Query: 900  KKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQC 959
            KK REY  LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KELCGL  +A+L QC
Sbjct: 867  KKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQC 926

Query: 960  MLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENAD 1019
            +L +S R +  DNTP V L + + +P +E  G +P+V KK++T YD+MIQ  + LIE AD
Sbjct: 927  LLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMAD 986

Query: 1020 AVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKN 1079
             V EKIV CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKN
Sbjct: 987  TVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKN 1046

Query: 1080 ETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 1124
            E +EN+KQI  A +SCGL+K  + +A+  K +RSLE I EK + E
Sbjct: 1047 EAIENMKQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 1090


>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
          Length = 997

 Score = 1374 bits (3556), Expect = 0.0
 Identities = 667/999 (66%), Positives = 807/999 (80%), Gaps = 8/999 (0%)

Query: 127  MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 186
            MP+EKKISSA+DCI+ M  G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+
Sbjct: 1    MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60

Query: 187  DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 246
            DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL
Sbjct: 61   DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120

Query: 247  RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 306
            RYL+S  K  LD +E +Q+  R  W+  +F   DVD  G +    +V+ I+ LNP LK +
Sbjct: 121  RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180

Query: 307  KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 366
            KI LKFKE+ KSK+K  T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD  DLM+F
Sbjct: 181  KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240

Query: 367  LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 426
            LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q
Sbjct: 241  LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300

Query: 427  DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 486
            DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++  
Sbjct: 301  DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360

Query: 487  GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 546
             + MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G+KLYT 
Sbjct: 361  RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420

Query: 547  SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 605
            +P   ESYLPSP+ LK  I++K KKL S+   +EG+VTDEDE AEMS+RM  + N EQ  
Sbjct: 421  APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQ-- 478

Query: 606  NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 665
                K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E  AS+ ANE P DFV
Sbjct: 479  ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534

Query: 666  NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 725
            NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG
Sbjct: 535  NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594

Query: 726  YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785
            YVLRP+IMR+EVS+FSANTK  +PGVSP  LHIKIISGQNFPKPKG+ AKGDV+DPYV +
Sbjct: 595  YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654

Query: 786  EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 845
            EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY
Sbjct: 655  EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714

Query: 846  TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 905
            TIPFECLQ GYRHVPL+S  G+++ H +LFVH+AITNR GGGK  KR LSVR GKK REY
Sbjct: 715  TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774

Query: 906  ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 965
              LR + +KT+D++FK A  P+R+A D+RENMQNA+VS KELCGL  +A+L QC+L +S 
Sbjct: 775  TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834

Query: 966  RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKI 1025
            R +  DNTP V L + + +P +E  G +P+V KK++T YD+MIQ  + LIE AD V EKI
Sbjct: 835  RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKI 894

Query: 1026 VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENL 1085
            V CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKNE +EN+
Sbjct: 895  VQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENM 954

Query: 1086 KQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 1124
            KQI  A +SCGL+K  + +A+  K +RSLE I EK + E
Sbjct: 955  KQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 992


>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
          Length = 762

 Score =  509 bits (1312), Expect = e-144
 Identities = 294/756 (38%), Positives = 436/756 (57%), Gaps = 38/756 (5%)

Query: 143 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 202
           M EG  ++KVRS S    RYF L  D  ++      + S K    I  ++ +R G ++++
Sbjct: 18  MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77

Query: 203 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262
            RS  +++++  +  F++++     +LDL+ANS + A IW+ GL+ L+       D++ S
Sbjct: 78  LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128

Query: 263 SQDNMRTS-WVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDK 321
                R   W+S  F   D +  G ++     + +  +N  +     E  F     +   
Sbjct: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185

Query: 322 AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEIS 381
               +  EEF++ +  L  R E+  L   FS++ + L   + + FL+ EQ       E++
Sbjct: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245

Query: 382 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSH 441
           LE+I +YEPS  G+ +  LS+DGF +YL S D  IF+P    + QDM QPL+HYFI SSH
Sbjct: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305

Query: 442 NTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVID 501
           NTYL+ DQ  G S + GYIRALK GCR VE+DVWDGP  EPV+Y GHT+TS+I+F+ V+ 
Sbjct: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365

Query: 502 IINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLY-TTSPNVEESYLPSPDV 560
            + +YAF  S+YP+IL LE HCS +QQ+ M +H+ ++LG++L  TT   V  + LPSP+ 
Sbjct: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEE 425

Query: 561 LKGKILIKAKKLSSNCSGVEGDVTDEDEGA---------------EMSQRMGKENMEQPN 605
           L+ KIL+K KKL+     +E D+  E+E A               E      ++N++  +
Sbjct: 426 LRRKILVKGKKLT-----LEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD 480

Query: 606 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 665
                +  LC  LS LV   KSV F+ F  S +   ++E+ SF+E  A +   E   +FV
Sbjct: 481 KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV 540

Query: 666 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 725
            +N   L+RV+PS +R DSSN NPQ+ W  GCQ+VAMN QT GL MD+  G FRQNG CG
Sbjct: 541 QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG 600

Query: 726 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785
           YVL+P  +R+  S F  + +  +     Q L I++ISGQ  PK   +  +G +VDP V V
Sbjct: 601 YVLKPDFLRDIQSSF--HPEKPISPFKAQTLLIQVISGQQLPKVDKT-KEGSIVDPLVKV 657

Query: 786 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQ 844
           +I G+  D A Q T  V  NG  P + ++  F++ +PELAM+RFVV+D D+   ++FIGQ
Sbjct: 658 QIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQ 717

Query: 845 YTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
           YT+P+ C+Q GYRH+ L S  G  L  AS+FV++ I
Sbjct: 718 YTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753


>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
          Length = 756

 Score =  484 bits (1247), Expect = e-136
 Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%)

Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 196
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 19  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77

Query: 197 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 256
           G  T+       +  + ED  FS+++ +   +LDL+A S   A  WV GL  +I +   +
Sbjct: 78  GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 134

Query: 257 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 316
           +D  +  Q      W+     + D +    ++       ++ LN  +  S     F+E  
Sbjct: 135 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 188

Query: 317 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 375
              D + T+  ++E IE F+++ T R EI     + + + E L    L+ FL+ +Q    
Sbjct: 189 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 245

Query: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 435
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 305

Query: 436 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 495
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 306 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365

Query: 496 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 555
           F  V+  I  YAF AS YP+IL LENHC+++QQ+VM +H+  +LG  L     +   + L
Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 425

Query: 556 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 609
           PSP+ LKGKIL+K KKL      G EG      V+DEDE AEM     +  ++  +    
Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 483

Query: 610 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 668
            + +L +ELS++V  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +N
Sbjct: 484 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 543

Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728
              L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+  G F+ NG CGYVL
Sbjct: 544 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 603

Query: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788
           +PA +R+    F+       P  + + L+I++ISGQ  PK   +  K  +VDP V VEIH
Sbjct: 604 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 661

Query: 789 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 847
           G+  D A ++T  +  NG  P +D  F F++ +P+LA++RF+V D D    ++FIGQ TI
Sbjct: 662 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 721

Query: 848 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
           P   L+ GYRHV L S  G+    A+LFV +++
Sbjct: 722 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754


>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
          Length = 777

 Score =  484 bits (1247), Expect = e-136
 Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%)

Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 196
           + ++++GS+L KV+S+S    R++ L  D +++ W+ S+K     E     I+ I+EVR 
Sbjct: 40  LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98

Query: 197 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 256
           G  T+       +  + ED  FS+++ +   +LDL+A S   A  WV GL  +I +   +
Sbjct: 99  GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 155

Query: 257 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 316
           +D  +  Q      W+     + D +    ++       ++ LN  +  S     F+E  
Sbjct: 156 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 209

Query: 317 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 375
              D + T+  ++E IE F+++ T R EI     + + + E L    L+ FL+ +Q    
Sbjct: 210 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 266

Query: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 435
               ++L +I +YEPS+  + +  ++ DGF  YL+S D   F   H++V QDM QPLSHY
Sbjct: 267 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 326

Query: 436 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 495
            ++SSHNTYL+EDQ  GPS    YIRAL  GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 327 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 386

Query: 496 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 555
           F  V+  I  YAF AS YP+IL LENHC+++QQ+VM +H+  +LG  L     +   + L
Sbjct: 387 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 446

Query: 556 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 609
           PSP+ LKGKIL+K KKL      G EG      V+DEDE AEM     +  ++  +    
Sbjct: 447 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 504

Query: 610 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 668
            + +L +ELS++V  CKSV F  F       Q ++E+ SF+E  A +   E+   FV +N
Sbjct: 505 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 564

Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728
              L+R++P+  R DSSN +P + W  GCQIVA+NFQTPG  MD+  G F+ NG CGYVL
Sbjct: 565 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 624

Query: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788
           +PA +R+    F+       P  + + L+I++ISGQ  PK   +  K  +VDP V VEIH
Sbjct: 625 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 682

Query: 789 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 847
           G+  D A ++T  +  NG  P +D  F F++ +P+LA++RF+V D D    ++FIGQ TI
Sbjct: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742

Query: 848 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
           P   L+ GYRHV L S  G+    A+LFV +++
Sbjct: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775


>gi|19115964 phospholipase C delta 3 [Homo sapiens]
          Length = 789

 Score =  452 bits (1163), Expect = e-127
 Identities = 279/750 (37%), Positives = 408/750 (54%), Gaps = 34/750 (4%)

Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKID-IKSIKEVRTGK 198
           + +M+ GS L+K+RS +    R + L  D  S+ ++     +    I  ++ I+ VR G 
Sbjct: 62  VRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGH 121

Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258
            ++  R  G     +     ++ +    ++LDL A +A+ A  WV GL  L    +  LD
Sbjct: 122 QSEGLRRFG--GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL----RARLD 175

Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKEL-HK 317
            +  SQ      W+       D +    ++       +R +N  +      L FKE  H 
Sbjct: 176 AM--SQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHS 233

Query: 318 SKDKA-GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHI 376
           + D+  G E+  EEF+     L  RPE+  +  Q+S     L   +L+ FLE +QG    
Sbjct: 234 NNDRLEGAEI--EEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 287

Query: 377 NEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYF 436
               + ++I  YE ++  ++   +++DGF  YL+SP+    D  H  V QDM QPL+HYF
Sbjct: 288 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 347

Query: 437 INSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVF 496
           I+SSHNTYL + Q  GPS    Y+RA   GCR VELD W+GP  EPVIY GHT+TS+I+F
Sbjct: 348 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 407

Query: 497 RSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT---TSPNVEES 553
           R V+  +  +AF  S YP+IL LENHC ++QQ  M +H+  +LGD L T    SPN EE 
Sbjct: 408 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEE- 466

Query: 554 YLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRF- 612
            LPSP+ LKG++L+K KKL +  S     ++D +E  E  +    E  E+      +R  
Sbjct: 467 -LPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDE----EEEEEVEAAAQRRLA 521

Query: 613 -QLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRF 671
            Q+  ELS L   C + + +    +    +  +V S +E  A K   E    FV +N R 
Sbjct: 522 KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581

Query: 672 LARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPA 731
           L RV+P  +R++S+N +PQ+ W  GCQ+VA+NFQTPG  MDLN G F  NG CGYVL+PA
Sbjct: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641

Query: 732 IMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIP 791
            +R+  S F        PG     L I++++ Q  PK   +     +VDP V +EIHG+P
Sbjct: 642 CLRQPDSTFD----PEYPGPPRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIHGVP 696

Query: 792 ADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFE 850
           ADCA Q T  V  NG  P + ++ +FQ+  PELA+VRFVV D D    ++F+GQ+T+P  
Sbjct: 697 ADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLS 756

Query: 851 CLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
            L+ GYRH+ L S  G  L+ A+LF+ + I
Sbjct: 757 SLKQGYRHIHLLSKDGASLSPATLFIQIRI 786


>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
          Length = 608

 Score =  441 bits (1134), Expect = e-123
 Identities = 238/576 (41%), Positives = 354/576 (61%), Gaps = 22/576 (3%)

Query: 313 KELHKSKDKAGT-EVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQ 371
           K++ K  D+     +T EEF  ++  +  R EI  +   +S N++ L   +L  FL  EQ
Sbjct: 41  KQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQ 100

Query: 372 GVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQP 431
             A +++ I+ EII KYEP +E ++   +S++GFT Y+ S +C +F  E +KV QDM  P
Sbjct: 101 YAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHP 160

Query: 432 LSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMT 491
           L+ YFI+SSHNTYL+ DQ  GPSD+ GY+ AL  GCR +E+D WDG  NEPV+Y G+T+T
Sbjct: 161 LNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLT 220

Query: 492 SQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVE 551
           S+++F++VI  I+KYAF  S+YP++L LENHCS  QQ+VM  +++   G+ L +   +  
Sbjct: 221 SKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDF 280

Query: 552 ESYLPSPDVLKGKILIKAKKLSS-------NCSGVEGDVTDEDEGAEMSQRMGKENMEQP 604
              LPSP+ LK KIL+K KK+ +         S   GD  D++ G +    +     ++ 
Sbjct: 281 PDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKK- 339

Query: 605 NNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDF 664
                ++ ++   LS+LV   K+ +FK FQ S   Q++ E  S  E  A K +     +F
Sbjct: 340 ----TRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEF 395

Query: 665 VNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNC 724
           + + ++F+ R++P   R DSSN NPQ+FW  GCQ+VA+NFQTPGL MDL  G F  NG  
Sbjct: 396 IFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGS 455

Query: 725 GYVLRPAIMREEVSFFS-ANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYV 783
           GY+L+P  +RE  S+F+ +N K+ +    P  L I++ISG   P    S  KGD +   V
Sbjct: 456 GYILKPHFLRESKSYFNPSNIKEGM----PITLTIRLISGIQLPLTHSSSNKGDSL---V 508

Query: 784 YVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYI-GDEFI 842
            +E+ G+P D  +Q+T+ + +N  +P ++E+F F I++PELA++RFVV     I G+EF+
Sbjct: 509 IIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFL 568

Query: 843 GQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHV 878
           GQYT+P  C+  GYR +PL S  GE L  ASLFV+V
Sbjct: 569 GQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604


>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
          Length = 1416

 Score =  380 bits (976), Expect = e-105
 Identities = 204/457 (44%), Positives = 291/457 (63%), Gaps = 9/457 (1%)

Query: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198
           C+ +M EG ++ K+R  S+   R++ LD     +RW PS+K+ EKAKI I SI+EV  G+
Sbjct: 45  CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103

Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258
            +++F+          +C FS+ +G + ESLDLV+ S++VA  WVTGLRYL++ G    D
Sbjct: 104 QSEVFQRYP-DGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMA-GISDED 161

Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318
            L   Q   R  W+ Q F E D +  G +++   +Q +  LN  L   +++  F+E   +
Sbjct: 162 SLARRQ-RTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD-T 219

Query: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378
            D  GT +  EEF   +  + TR ++Y L++ +S++K+ LD   L  FL+ EQ +A +  
Sbjct: 220 DDHQGT-LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTL 278

Query: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438
           E   +II ++EP  E + KG L IDGFTNY  SP   IF+PEH  V QDM QPLSHYFI 
Sbjct: 279 ESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFIT 338

Query: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498
           SSHNTYL+ DQ    S +  Y   L+ GCR VE+D WDGPD EP+++ G+T+TS+I+F+ 
Sbjct: 339 SSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKD 398

Query: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557
           VI+ INKYAF  +EYP+IL +ENHCS+ QQK M Q++  +LGDKL  +S + E+ + LPS
Sbjct: 399 VIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPS 458

Query: 558 PDVLKGKILIKAKKLSSNCS--GVEGDVTDEDEGAEM 592
           P +LKGKIL+K KKL +N S    EG+V+DED   E+
Sbjct: 459 PQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEI 495



 Score =  241 bits (616), Expect = 2e-63
 Identities = 129/320 (40%), Positives = 193/320 (60%), Gaps = 21/320 (6%)

Query: 568 KAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKS 627
           K  KL    S  EGD   +  G    Q  G    +       K  +L + LS+LV   KS
Sbjct: 586 KGSKLKKAASVEEGDEGQDSPGG---QSRGATRQK-------KTMKLSRALSDLVKYTKS 635

Query: 628 VQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNM 687
           V   + ++  +    W+V SF+E  A +   + P  ++ +N++ L+R++PS  R+DSSN 
Sbjct: 636 VATHDIEM--EAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNY 693

Query: 688 NPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDS 747
           NPQ FW  GCQ+VA+N+Q+ G M+ LN   F  NG CGYVL+P  M + V  F+ N++D 
Sbjct: 694 NPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDP 751

Query: 748 VPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQN 805
           +PG   + L ++IISGQ  PKP+ S  G +G+++DP+V VEI G+P DC+ ++T+ V  N
Sbjct: 752 LPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDN 811

Query: 806 GDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLT 865
           G  P ++E+  F +++PE+A+VRF+V D D IG +FIGQ T+ F  +  GYRHV L    
Sbjct: 812 GFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL---- 867

Query: 866 GEVLAHASLFVHVAITNRRG 885
            E +  AS+FVHVA+++  G
Sbjct: 868 -EGMEEASIFVHVAVSDISG 886


>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
          Length = 1002

 Score =  344 bits (882), Expect = 3e-94
 Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%)

Query: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198
           C++ M  G+++ K++  ++   R F LD     LRW PS+K SEKAKI I SI +V  G+
Sbjct: 18  CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76

Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258
            ++IF            C F++ +G + ESLDL+ ++ + A  W+TGL+YL++ G    D
Sbjct: 77  QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134

Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318
            L   Q      WV Q F E D +  G + +    Q +  LN  L   K+   F+E    
Sbjct: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193

Query: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378
           +++ GT +T EEF   +  +  R ++Y LL+ +S  K+ L  ++L  FL+ EQ + ++  
Sbjct: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251

Query: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438
           +  L+II K+E S+E + K  L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I 
Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311

Query: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498
           SSHNTYL  DQ    S +  Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR 
Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371

Query: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557
           V++ INK+AF  +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL  +S +  E   LPS
Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431

Query: 558 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592
           P  LKGKIL+K KKL  +      EG+V+DED   E+
Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468



 Score =  227 bits (578), Expect = 6e-59
 Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%)

Query: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620
           GK     K  S + S  + + T +  G E  Q  R+G+           K  +LC+ELS+
Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603

Query: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680
           LV    SV  ++            V SF+E  A +   +    F+ YN++ L R++PS  
Sbjct: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660

Query: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740
           RIDSSN NP  +W  GCQ+VA+N+Q+ G MM LN   F+ NGNCGYVL+P  M +    F
Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718

Query: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798
           +  + D +P    + L +K+ISGQ  PKP  S  G +G+++DP+V VEI G+P DC + +
Sbjct: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778

Query: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
           T+ V  NG  P+++E+  F +++PE+A+VRF+V D D IG +F+GQ T+ F  L  GYRH
Sbjct: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838

Query: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 889
           V L+ LT      AS+FVH+ I    G   P
Sbjct: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864


>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
          Length = 1693

 Score =  344 bits (882), Expect = 3e-94
 Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%)

Query: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198
           C++ M  G+++ K++  ++   R F LD     LRW PS+K SEKAKI I SI +V  G+
Sbjct: 18  CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76

Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258
            ++IF            C F++ +G + ESLDL+ ++ + A  W+TGL+YL++ G    D
Sbjct: 77  QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134

Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318
            L   Q      WV Q F E D +  G + +    Q +  LN  L   K+   F+E    
Sbjct: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193

Query: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378
           +++ GT +T EEF   +  +  R ++Y LL+ +S  K+ L  ++L  FL+ EQ + ++  
Sbjct: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251

Query: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438
           +  L+II K+E S+E + K  L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I 
Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311

Query: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498
           SSHNTYL  DQ    S +  Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR 
Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371

Query: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557
           V++ INK+AF  +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL  +S +  E   LPS
Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431

Query: 558 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592
           P  LKGKIL+K KKL  +      EG+V+DED   E+
Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468



 Score =  227 bits (578), Expect = 6e-59
 Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%)

Query: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620
           GK     K  S + S  + + T +  G E  Q  R+G+           K  +LC+ELS+
Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603

Query: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680
           LV    SV  ++            V SF+E  A +   +    F+ YN++ L R++PS  
Sbjct: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660

Query: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740
           RIDSSN NP  +W  GCQ+VA+N+Q+ G MM LN   F+ NGNCGYVL+P  M +    F
Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718

Query: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798
           +  + D +P    + L +K+ISGQ  PKP  S  G +G+++DP+V VEI G+P DC + +
Sbjct: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778

Query: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
           T+ V  NG  P+++E+  F +++PE+A+VRF+V D D IG +F+GQ T+ F  L  GYRH
Sbjct: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838

Query: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 889
           V L+ LT      AS+FVH+ I    G   P
Sbjct: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864


>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
          Length = 1655

 Score =  340 bits (873), Expect = 3e-93
 Identities = 188/453 (41%), Positives = 276/453 (60%), Gaps = 9/453 (1%)

Query: 143 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 202
           M  G+++ K++  ++   R F LD     LRW PS+K SEKAKI I SI +V  G+ ++I
Sbjct: 4   MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGRQSEI 62

Query: 203 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262
           F            C F++ +G + ESLDL+ ++ + A  W+TGL+YL++ G    D L  
Sbjct: 63  FHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDEDSLAK 120

Query: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322
            Q      WV Q F E D +  G + +    Q +  LN  L   K+   F+E    +++ 
Sbjct: 121 RQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ- 178

Query: 323 GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISL 382
           GT +T EEF   +  +  R ++Y LL+ +S  K+ L  ++L  FL+ EQ + ++  +  L
Sbjct: 179 GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCL 237

Query: 383 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHN 442
           +II K+E S+E + K  L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I SSHN
Sbjct: 238 DIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHN 297

Query: 443 TYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDI 502
           TYL  DQ    S +  Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR V++ 
Sbjct: 298 TYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVET 357

Query: 503 INKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPSPDVL 561
           INK+AF  +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL  +S +  E   LPSP  L
Sbjct: 358 INKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSL 417

Query: 562 KGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592
           KGKIL+K KKL  +      EG+V+DED   E+
Sbjct: 418 KGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 450



 Score =  226 bits (577), Expect = 7e-59
 Identities = 135/349 (38%), Positives = 195/349 (55%), Gaps = 24/349 (6%)

Query: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620
           GK     K  S + S  + + T +  G E  Q  R+G+           K  +LC+ELS+
Sbjct: 535 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 585

Query: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680
           LV    SV  ++            V SF+E  A +   +    F+ YN++ L R++PS  
Sbjct: 586 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 642

Query: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740
           RIDSSN NP  +W  GCQ+VA+N+Q+ G MM LN   F+ NGNCGYVL+P  M +    F
Sbjct: 643 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 700

Query: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798
           +  + D +P    + L +K+ISGQ  PKP  S  G +G+++DP+V VEI G+P DC + +
Sbjct: 701 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 760

Query: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
           T+ V  NG  P+++E+  F +++PE+A+VRF+V D D IG +F+GQ T+ F  L  GYRH
Sbjct: 761 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 820

Query: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYAS 907
           V L+ LT      AS+FVH+ I N   G     +GL     K  R  +S
Sbjct: 821 VYLEGLT-----EASIFVHITI-NEIYGKNRQLQGLKGLFNKNPRHSSS 863


>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
          Length = 1194

 Score =  336 bits (861), Expect = 8e-92
 Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%)

Query: 145 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 197
           EG+   +    S ++    L   D     L W    K+ +  +  +  I  +R+G     
Sbjct: 19  EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76

Query: 198 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 253
            K      + G S+   E     V  G +  ++    +VA + +V   WV GLR +I   
Sbjct: 77  PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134

Query: 254 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 310
                       N R + VS M   +     L  +T  N    +R++     + K E   
Sbjct: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182

Query: 311 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 363
               KEL     K+ +   T  + E+F E+  ++C R +I  L  + + +K ++L    L
Sbjct: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242

Query: 364 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 415
           + FL   Q    +NE +        +++II  YEP ++ ++KG +S DGF  YLMS +  
Sbjct: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302

Query: 416 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 475
               +  ++ Q+M  PL+HYFI+SSHNTYL   QF G S +  Y + L  GCR VELD W
Sbjct: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362

Query: 476 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 533
           D  G D EP+I  G  M + I+F+ VI  I + AF  SEYP+IL  ENHCS  QQ  M +
Sbjct: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422

Query: 534 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 572
           + + L GD L      + P      LPSP+ LK KILIK K+L                 
Sbjct: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482

Query: 573 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 609
               +S  + +E D  +E E A+  +      + G E             N  +   V V
Sbjct: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542

Query: 610 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 655
           +  Q              +   LS +++  + V+F+ F V+ +   ++ + SFNE +   
Sbjct: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602

Query: 656 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 715
           Y   +  +FVNYNKR ++R++P   R+DSSN  PQ FW  GCQ+V++N+QTP L M LN 
Sbjct: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662

Query: 716 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 775
           G F  NG+CGY+L+P  MR     F   ++  V GV      +++ISGQ     K     
Sbjct: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717

Query: 776 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 831
              +  YV V+++G+P D    E RT+ V  NG  P++ +ESF F ++ LP+LA++R  V
Sbjct: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774

Query: 832 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
            DD+   ++ IGQ  +P + LQ GYRH+ L++   + L+  ++F ++ +
Sbjct: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820


>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
          Length = 1175

 Score =  336 bits (861), Expect = 8e-92
 Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%)

Query: 145 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 197
           EG+   +    S ++    L   D     L W    K+ +  +  +  I  +R+G     
Sbjct: 19  EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76

Query: 198 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 253
            K      + G S+   E     V  G +  ++    +VA + +V   WV GLR +I   
Sbjct: 77  PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134

Query: 254 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 310
                       N R + VS M   +     L  +T  N    +R++     + K E   
Sbjct: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182

Query: 311 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 363
               KEL     K+ +   T  + E+F E+  ++C R +I  L  + + +K ++L    L
Sbjct: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242

Query: 364 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 415
           + FL   Q    +NE +        +++II  YEP ++ ++KG +S DGF  YLMS +  
Sbjct: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302

Query: 416 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 475
               +  ++ Q+M  PL+HYFI+SSHNTYL   QF G S +  Y + L  GCR VELD W
Sbjct: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362

Query: 476 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 533
           D  G D EP+I  G  M + I+F+ VI  I + AF  SEYP+IL  ENHCS  QQ  M +
Sbjct: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422

Query: 534 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 572
           + + L GD L      + P      LPSP+ LK KILIK K+L                 
Sbjct: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482

Query: 573 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 609
               +S  + +E D  +E E A+  +      + G E             N  +   V V
Sbjct: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542

Query: 610 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 655
           +  Q              +   LS +++  + V+F+ F V+ +   ++ + SFNE +   
Sbjct: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602

Query: 656 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 715
           Y   +  +FVNYNKR ++R++P   R+DSSN  PQ FW  GCQ+V++N+QTP L M LN 
Sbjct: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662

Query: 716 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 775
           G F  NG+CGY+L+P  MR     F   ++  V GV      +++ISGQ     K     
Sbjct: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717

Query: 776 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 831
              +  YV V+++G+P D    E RT+ V  NG  P++ +ESF F ++ LP+LA++R  V
Sbjct: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774

Query: 832 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
            DD+   ++ IGQ  +P + LQ GYRH+ L++   + L+  ++F ++ +
Sbjct: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820


>gi|12083581 phosphoinositide-specific phospholipase C beta 1
           isoform a [Homo sapiens]
          Length = 1216

 Score =  326 bits (835), Expect = 9e-89
 Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)

Query: 141 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 200
           +S+ +G++  K   +S I     +L  D Q   +  + ++ E   +D+  +K+ R G++ 
Sbjct: 20  DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78

Query: 201 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 250
              +   + + +        E    +V+YG    N   L+LVA   +VA  W   +  L 
Sbjct: 79  KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138

Query: 251 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 308
           +      ++L  +Q+  R +++ + ++++   V   G I L N     R  +   K  + 
Sbjct: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187

Query: 309 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 365
            L+   L  S++ +    + T E +    + LC RPEI  +  +F + +K +L    +M 
Sbjct: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247

Query: 366 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 417
           F+  +Q    +NE        E    +I KYEP+     KG +S+DGF  YL   +  + 
Sbjct: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307

Query: 418 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 477
            PE   + +DM QPLSHYFINSSHNTYL   Q  G S +  Y + L  GCR VELD W G
Sbjct: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367

Query: 478 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 534
              + EPVI  G TMT++I F+ VI+ I + AF  S +P++L  ENH  S KQQ  M ++
Sbjct: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427

Query: 535 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 580
            + + GD L        P      LPSP  L  KIL+K KK S   S  SG +       
Sbjct: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487

Query: 581 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 623
                            G+   E +  +      K +M++            +E+S LV+
Sbjct: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545

Query: 624 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 683
             + V+F+ F++S +  K +E+ SF E    +   ++P +FV YNK  L+R++P   R+D
Sbjct: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605

Query: 684 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 743
           SSN  PQ FW  GCQ+VA+NFQT  L M +N+G +  NG  GY L+P  MR     F   
Sbjct: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665

Query: 744 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 801
           T+  V G+    L +KIISGQ     K        V  YV V++ G+P D   +  +TKT
Sbjct: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717

Query: 802 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
              N   P+++E    F+ ++ LP LA +R  V ++   G +FIG   +P + ++ GY +
Sbjct: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773

Query: 859 VPLQSLTGEVLAHASLFVHVAI 880
           + L++   + L   ++FV++ +
Sbjct: 774 ICLRNERNQPLTLPAVFVYIEV 795


>gi|33356544 phosphoinositide-specific phospholipase C beta 1
           isoform b [Homo sapiens]
          Length = 1173

 Score =  326 bits (835), Expect = 9e-89
 Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%)

Query: 141 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 200
           +S+ +G++  K   +S I     +L  D Q   +  + ++ E   +D+  +K+ R G++ 
Sbjct: 20  DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78

Query: 201 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 250
              +   + + +        E    +V+YG    N   L+LVA   +VA  W   +  L 
Sbjct: 79  KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138

Query: 251 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 308
           +      ++L  +Q+  R +++ + ++++   V   G I L N     R  +   K  + 
Sbjct: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187

Query: 309 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 365
            L+   L  S++ +    + T E +    + LC RPEI  +  +F + +K +L    +M 
Sbjct: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247

Query: 366 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 417
           F+  +Q    +NE        E    +I KYEP+     KG +S+DGF  YL   +  + 
Sbjct: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307

Query: 418 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 477
            PE   + +DM QPLSHYFINSSHNTYL   Q  G S +  Y + L  GCR VELD W G
Sbjct: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367

Query: 478 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 534
              + EPVI  G TMT++I F+ VI+ I + AF  S +P++L  ENH  S KQQ  M ++
Sbjct: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427

Query: 535 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 580
            + + GD L        P      LPSP  L  KIL+K KK S   S  SG +       
Sbjct: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487

Query: 581 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 623
                            G+   E +  +      K +M++            +E+S LV+
Sbjct: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545

Query: 624 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 683
             + V+F+ F++S +  K +E+ SF E    +   ++P +FV YNK  L+R++P   R+D
Sbjct: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605

Query: 684 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 743
           SSN  PQ FW  GCQ+VA+NFQT  L M +N+G +  NG  GY L+P  MR     F   
Sbjct: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665

Query: 744 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 801
           T+  V G+    L +KIISGQ     K        V  YV V++ G+P D   +  +TKT
Sbjct: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717

Query: 802 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
              N   P+++E    F+ ++ LP LA +R  V ++   G +FIG   +P + ++ GY +
Sbjct: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773

Query: 859 VPLQSLTGEVLAHASLFVHVAI 880
           + L++   + L   ++FV++ +
Sbjct: 774 ICLRNERNQPLTLPAVFVYIEV 795


>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
          Length = 1185

 Score =  305 bits (780), Expect = 2e-82
 Identities = 246/778 (31%), Positives = 374/778 (48%), Gaps = 100/778 (12%)

Query: 172 LRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDC--------AFSVIYG 223
           L W    K+ E   +DI SI++ R GK   + +S  + D  + D           +V+ G
Sbjct: 47  LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104

Query: 224 ENYESL---DLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI- 279
            +   L   + V+   +V   W   +  L+   KH L    S     R++++ ++  ++ 
Sbjct: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPLTANAS-----RSTFLDKILVKLK 156

Query: 280 -DVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHE- 337
             +++ G I + N  Q            ++E      H  K K    +  E+F E  ++ 
Sbjct: 157 MQLNSEGKIPVKNFFQMFP-----ADRKRVEAALSACHLPKGK-NDAINPEDFPEPVYKS 210

Query: 338 ----LCTRPEIYFLLVQFSSN-KEFLDTKDLMMFLEAEQGVAHINEEISLE--------I 384
               LC RPEI  +   + +  K ++  + L  F+  +Q  + +N  +           +
Sbjct: 211 FLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGL 270

Query: 385 IHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTY 444
           I KYEPS    ++G LS +G   +L  P+  +   +   +  DM QPL+HYFINSSHNTY
Sbjct: 271 IDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTY 330

Query: 445 LIEDQFRGPSDITGYIRALKMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDI 502
           L   QF G S    Y + L  GCR VELD W G  PD EP+I  G TMT+ I F+  I+ 
Sbjct: 331 LTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEA 390

Query: 503 INKYAFFASEYPLILCLENHC-SIKQQKVMVQHMKKLLGDKLYTTS----PNVEESYLPS 557
           I + AF  S YP+IL  ENH  S +QQ  M ++ + + GD L T      P      LPS
Sbjct: 391 IAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPS 450

Query: 558 PDVLKGKILIKAKK-------LSSNCSGVE-------------GDVTDEDEGAEMSQR-M 596
           P+ L+GKILIK KK        SS  +G E             G V   +EG E+ +  +
Sbjct: 451 PEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEV 510

Query: 597 GKENMEQPNNVP---VKRFQ-----------LCKELSELVSICKSVQFKEFQVSFQVQKY 642
            +E  E+  N+    +K+ Q             +E+S LV+  +  +F  F+ S Q  + 
Sbjct: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570

Query: 643 WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 702
           + + SF E+ A    ++    FV+YNKR ++R++P   R+DSSN  PQ FW  GCQ+VA+
Sbjct: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630

Query: 703 NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 762
           NFQT  L M  N+  F  NG  GY+L+   MR     F+  + D +  V    L I +IS
Sbjct: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690

Query: 763 GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTK-TVHQNGDAPIF-DESFEFQ- 818
           GQ   +          V  YV VE+ G+P D   + RTK +   N   P++ +E F F+ 
Sbjct: 691 GQFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEK 742

Query: 819 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876
           I +PELA +R  V+++   G++F+G   IP   L +GY H+ L S +   L   +LF+
Sbjct: 743 ILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797


>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
          Length = 1291

 Score =  218 bits (554), Expect = 3e-56
 Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%)

Query: 153 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 212
           + + R   + F +  + + + W       E A IDI+ IKE+R GK +  F      D+ 
Sbjct: 41  KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93

Query: 213 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262
            ED AF         ++YG  +  ++L L A S D  N+W+ GL +L+       D L++
Sbjct: 94  QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147

Query: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322
                   W+ + F  +D +    I+  +    +  +N  +   +     +E     ++ 
Sbjct: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204

Query: 323 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 373
             ++T  +F +++  L          P +    ++     E   +   +   FL   QG 
Sbjct: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264

Query: 374 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 429
               + + ++   +    +P +E +E  +  +D F  +L S +  +++ +   VC D M 
Sbjct: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323

Query: 430 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 489
            PLSHY+I+SSHNTYL  DQF   S +  Y R L+MGCR +ELD WDGPD  PVIY GHT
Sbjct: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383

Query: 490 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 549
           +T++I F  V+  I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T    
Sbjct: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443

Query: 550 VEESYLPSPDVLKGKILIKAKKLS 573
           +    LPSP+ LK KILIK KKL+
Sbjct: 444 ISADGLPSPNQLKRKILIKHKKLA 467



 Score =  187 bits (475), Expect = 5e-47
 Identities = 108/274 (39%), Positives = 162/274 (59%), Gaps = 10/274 (3%)

Query: 610  KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 668
            +R ++  ELSELV  C+ V F E ++  +   Y ++ SF E  A KY N+  G  F+ YN
Sbjct: 945  RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004

Query: 669  KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728
            +  L+R++P   R+DSSN +P   W CG Q+VA+NFQTP   M +N   F    +CGYVL
Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064

Query: 729  RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788
            +P+ MR+E   F    K S+ G+ P  + I+++  ++ PK  G G    +V P+V +E+ 
Sbjct: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117

Query: 789  GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 846
            G   D  +Q+T+ V  NG  P++  + F FQI+ PE A +RFVV ++D   D+ F+ Q T
Sbjct: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177

Query: 847  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
             P + L+TGYR VPL++   E L  ASL + + I
Sbjct: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211


>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
          Length = 1290

 Score =  218 bits (554), Expect = 3e-56
 Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%)

Query: 153 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 212
           + + R   + F +  + + + W       E A IDI+ IKE+R GK +  F      D+ 
Sbjct: 41  KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93

Query: 213 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262
            ED AF         ++YG  +  ++L L A S D  N+W+ GL +L+       D L++
Sbjct: 94  QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147

Query: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322
                   W+ + F  +D +    I+  +    +  +N  +   +     +E     ++ 
Sbjct: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204

Query: 323 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 373
             ++T  +F +++  L          P +    ++     E   +   +   FL   QG 
Sbjct: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264

Query: 374 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 429
               + + ++   +    +P +E +E  +  +D F  +L S +  +++ +   VC D M 
Sbjct: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323

Query: 430 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 489
            PLSHY+I+SSHNTYL  DQF   S +  Y R L+MGCR +ELD WDGPD  PVIY GHT
Sbjct: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383

Query: 490 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 549
           +T++I F  V+  I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T    
Sbjct: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443

Query: 550 VEESYLPSPDVLKGKILIKAKKLS 573
           +    LPSP+ LK KILIK KKL+
Sbjct: 444 ISADGLPSPNQLKRKILIKHKKLA 467



 Score =  188 bits (477), Expect = 3e-47
 Identities = 115/301 (38%), Positives = 170/301 (56%), Gaps = 15/301 (4%)

Query: 610  KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 668
            +R ++  ELSELV  C+ V F E ++  +   Y ++ SF E  A KY N+  G  F+ YN
Sbjct: 945  RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004

Query: 669  KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728
            +  L+R++P   R+DSSN +P   W CG Q+VA+NFQTP   M +N   F    +CGYVL
Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064

Query: 729  RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788
            +P+ MR+E   F    K S+ G+ P  + I+++  ++ PK  G G    +V P+V +E+ 
Sbjct: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117

Query: 789  GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 846
            G   D  +Q+T+ V  NG  P++  + F FQI+ PE A +RFVV ++D   D+ F+ Q T
Sbjct: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177

Query: 847  IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 906
             P + L+TGYR VPL++   E L  ASL + + I   +  G      LS   G   RE  
Sbjct: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRERG 1232

Query: 907  S 907
            S
Sbjct: 1233 S 1233


>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
          Length = 1265

 Score =  213 bits (541), Expect = 1e-54
 Identities = 145/446 (32%), Positives = 225/446 (50%), Gaps = 56/446 (12%)

Query: 180 DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 236
           D  +  +DI  IKE+R GKN+ D  R+  +  +  EDC F+++YG  +   +L L A+S 
Sbjct: 59  DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK--EDCCFTILYGTQFVLSTLSLAADSK 116

Query: 237 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCI 296
           + A  W++GL+ L        + + +S   +  SW+ +    +D      I+L      +
Sbjct: 117 EDAVNWLSGLKILHQ------EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170

Query: 297 RNLNPGLKTSK-IELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK 355
             +N  + ++K ++ KF E+   KD+           E FH       +++  + F   K
Sbjct: 171 PLINFKVSSAKFLKDKFVEIGAHKDELS--------FEQFH-------LFYKKLMFEQQK 215

Query: 356 EFLDT--KDLMMFL---------------EAEQGVAHINEEISLEIIHKY--------EP 390
             LD   KD  +F+               + ++ + H  +E   + ++K         + 
Sbjct: 216 SILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDD 275

Query: 391 SKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQ 449
           +     + +L +D F  YL S +  I+D ++  V  QDM  PLSHY+I+SSHNTYL  DQ
Sbjct: 276 TMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQ 335

Query: 450 FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFF 509
            R  S    YIR L+MGCR +ELD WDGPD +PVIY G T T++I F  V+  I  +AF 
Sbjct: 336 LRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395

Query: 510 ASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKA 569
            S +P+IL +E HCS++QQ+ M +  K++ GD L T         LPSP  L+ KI+IK 
Sbjct: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKH 455

Query: 570 KKLSSNCSGVEGDVTDEDEGAEMSQR 595
           KKL       + DV  ED+  E  Q+
Sbjct: 456 KKLGPR---GDVDVNMEDKKDEHKQQ 478



 Score =  144 bits (362), Expect = 6e-34
 Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 22/275 (8%)

Query: 610  KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNK 669
            K   +  ELS+LV  CK     + + + +   + E+ SF E  A     + P D + YN+
Sbjct: 922  KNQSIAIELSDLVVYCKPTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979

Query: 670  RFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 729
            + L RV+P   R+DSSN +P   W CG Q+VA+NFQT    M +N   F  NG  GYVL+
Sbjct: 980  KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039

Query: 730  PAIMREEVSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785
            P  MR E         D +P  S +     L +K++  ++ PK   S     +  P+V V
Sbjct: 1040 PESMRTE-------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEV 1087

Query: 786  EIHGIPADCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EF 841
            EI G   D  + +T  V+ NG +PI+    E   F+I  P LA +RFVV ++D   D  F
Sbjct: 1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNF 1147

Query: 842  IGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876
            +   T P + +++G+R VPL++   E +  ASL V
Sbjct: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182


>gi|11386139 phospholipase C beta 3 [Homo sapiens]
          Length = 1234

 Score =  181 bits (459), Expect = 3e-45
 Identities = 135/418 (32%), Positives = 214/418 (51%), Gaps = 44/418 (10%)

Query: 186 IDIKSIKEVRTGKNTDIFRSNGISDQIS--------EDCAFSVIYGE---NYESLDLVAN 234
           +DI SI++ RTG+   + +   I + +         E+   +V+ G    N   L+ +A 
Sbjct: 64  LDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAV 123

Query: 235 SADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNA 292
             D A +W   L          L M   +Q+  R +++ + ++++   V+  G I + N 
Sbjct: 124 QDDTAKVWSEEL--------FKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNI 175

Query: 293 VQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFS 352
           ++        ++T+ +E    + ++S+     E + E F    ++LC RP+I  +L++  
Sbjct: 176 LKMFSADKKRVETA-LESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIG 234

Query: 353 SN-KEFLDTKDLMMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSID 403
           +  K +L  + LM F+  +Q    +NE +        +  +I KYEP+++  E+  +S++
Sbjct: 235 AKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSME 294

Query: 404 GFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRAL 463
           GF+ YL   +  I   E   +  DM QPLS YFINSSHNTYL   Q  G S +  Y +AL
Sbjct: 295 GFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQAL 354

Query: 464 KMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLEN 521
             GCR VELDVW G  P+ EP I  G TMT+++  R V++ I + AF  S YP+IL  EN
Sbjct: 355 LWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFEN 414

Query: 522 HC-SIKQQKVMVQHMKKLLGDKL-------YTTSPNVEESYLPSPDVLKGKILIKAKK 571
           H  S KQQ  M ++ + + GD L       Y  +P V    LPSP  L G+IL+K KK
Sbjct: 415 HVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVP---LPSPQDLMGRILVKNKK 469



 Score =  171 bits (432), Expect = 5e-42
 Identities = 101/299 (33%), Positives = 159/299 (53%), Gaps = 14/299 (4%)

Query: 582 DVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQK 641
           D  DE+E  E  ++   +                +E+S LV+  + V+FK F+ + +  K
Sbjct: 554 DREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNK 613

Query: 642 YWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVA 701
            +E+ SF E  A +   ++P +FV YNK+ L+R++P   R+DSSN  PQ FW  GCQ+VA
Sbjct: 614 CFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVA 673

Query: 702 MNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKII 761
           +NFQT  + M LN G F  NG  GY+L+P  MR     F   T+  V G+    L +K+I
Sbjct: 674 LNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVI 733

Query: 762 SGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTKTVHQNGDAPIFDES-FEF-Q 818
           SGQ     K        V  YV V++ G+P D   + RT+T   N   P++DE  F+F +
Sbjct: 734 SGQFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 785

Query: 819 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVH 877
           + LP LA +R    ++   G +F+G   +P   +++GY +V L++   + L   +L ++
Sbjct: 786 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIY 841


>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
          Length = 2302

 Score =  170 bits (431), Expect = 6e-42
 Identities = 86/211 (40%), Positives = 134/211 (63%), Gaps = 5/211 (2%)

Query: 375  HINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF-DPEHKKVCQDMKQPLS 433
            H   +  L II K+EPS     +G +S +GF  +LM  + +   + E ++  ++++ PLS
Sbjct: 1340 HCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLS 1399

Query: 434  HYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQ 493
            +Y+I SSHNTYL   Q +G S +  Y + L  GCRSVELD WDG D  P+IY GHT+T++
Sbjct: 1400 YYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTK 1459

Query: 494  IVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT----TSPN 549
            I F+ V++ I++ AF  S+ P+I+ +ENHCS+ QQ+ M +  K + G+KL T     +  
Sbjct: 1460 IPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDF 1519

Query: 550  VEESYLPSPDVLKGKILIKAKKLSSNCSGVE 580
             ++  LPSPD L+ K+L+K KKL ++ + V+
Sbjct: 1520 SDDPMLPSPDQLRKKVLLKNKKLKAHQTPVD 1550



 Score =  141 bits (355), Expect = 4e-33
 Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 13/241 (5%)

Query: 641  KYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIV 700
            K + + S NE  A +           +    L R +P+  RIDSSN NP  FW  G Q+V
Sbjct: 1753 KCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLV 1812

Query: 701  AMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREE----VSFFSANTKDSVPGVSPQLL 756
            A+N+QT  L + LN   F  NG CGYVL+P ++ ++       FS   +D +  + P + 
Sbjct: 1813 ALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERD-LDSMDPAVY 1871

Query: 757  HIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFE 816
             + I+SGQN       G+      P + V++ G+P D    RTK +H+N   P+++E F 
Sbjct: 1872 SLTIVSGQNVCPSNSMGS------PCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFL 1925

Query: 817  FQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876
            F ++  +L  +RF V++++        Q  IP + L+ GYRH+ L++L  EVL  +SLF+
Sbjct: 1926 FHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983

Query: 877  H 877
            +
Sbjct: 1984 N 1984


>gi|223633890 hypothetical protein LOC729956 [Homo sapiens]
          Length = 538

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 34/99 (34%), Positives = 44/99 (44%), Gaps = 1/99 (1%)

Query: 8   GAAGGALPTSPGPALGAKGALKAG-VGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGD 66
           G AGGA     GP  G  G L+ G  G  GG GG    G   Y   GV +   ++GV   
Sbjct: 145 GGAGGAGGAGGGPGPGQAGWLEGGRTGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAK 204

Query: 67  EARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRS 105
            A +  +R PR       P A+V  L  ++ PG  P R+
Sbjct: 205 VAFSKASRAPRAHRDINVPRALVDILRHQAGPGTRPDRA 243


>gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens]
          Length = 749

 Score = 43.9 bits (102), Expect = 9e-04
 Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 8/87 (9%)

Query: 773 GAKGDVVD---PYVYVEIHGIPADCAEQRTKTVHQNGDA-PIFDESFEFQINLPELAMVR 828
           GA GD++D   PYV + I   P    + R +T H N D  P+++E+FEF ++  +  ++ 
Sbjct: 33  GAFGDMLDTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLE 88

Query: 829 FVVLDDDYIGDEFIGQYTIPFECLQTG 855
             ++D +Y+ DE +G  T     ++ G
Sbjct: 89  ITLMDANYVMDETLGTATFTVSSMKVG 115


>gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens]
          Length = 858

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 22/65 (33%), Positives = 35/65 (53%), Gaps = 2/65 (3%)

Query: 756 LHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESF 815
           +H+ I+ G N P P G     D +D +V  E H   +D A++    V +N ++P FD+ F
Sbjct: 701 MHLIIVRGMNLPAPPG--VTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLF 758

Query: 816 EFQIN 820
           +  IN
Sbjct: 759 KLNIN 763


>gi|55956899 keratin 9 [Homo sapiens]
          Length = 623

 Score = 41.2 bits (95), Expect = 0.006
 Identities = 27/72 (37%), Positives = 32/72 (44%), Gaps = 1/72 (1%)

Query: 7   GGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGD 66
           GG +GG      G   G+ G+   G G GGG GG  G G     SGG S G  S G  G+
Sbjct: 499 GGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGG-SGGGHSGGSGGN 557

Query: 67  EARASPTRGPRG 78
               S + G  G
Sbjct: 558 YGGGSGSGGGSG 569



 Score = 36.6 bits (83), Expect = 0.14
 Identities = 24/61 (39%), Positives = 28/61 (45%), Gaps = 1/61 (1%)

Query: 5   GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVS 64
           GRGG+ G     S G + G+ G   +G G GGG G R G G   Y  G  S G    G  
Sbjct: 477 GRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSG-GSYGGGSGSGGGSGGGYG 535

Query: 65  G 65
           G
Sbjct: 536 G 536



 Score = 36.2 bits (82), Expect = 0.18
 Identities = 23/74 (31%), Positives = 26/74 (35%), Gaps = 1/74 (1%)

Query: 5   GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVS 64
           G GG+ GG   +  G   G  G    G   GG GGG  G     Y  G  S G    G  
Sbjct: 515 GSGGSYGGGSGSGGGSG-GGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYG 573

Query: 65  GDEARASPTRGPRG 78
           G       + G  G
Sbjct: 574 GGSGSRGGSGGSHG 587



 Score = 35.4 bits (80), Expect = 0.31
 Identities = 20/53 (37%), Positives = 23/53 (43%)

Query: 5   GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNG 57
           G GG +GG      G   G+ G+   G G GG  GG  G G     SGG   G
Sbjct: 563 GSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGG 615



 Score = 34.7 bits (78), Expect = 0.52
 Identities = 20/53 (37%), Positives = 23/53 (43%)

Query: 5   GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNG 57
           G GG  GG   +  G      G   +G G GGG GG  G G +    GG S G
Sbjct: 501 GSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGG 553



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 22/56 (39%), Positives = 25/56 (44%), Gaps = 8/56 (14%)

Query: 5   GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYD--SGGVSNGD 58
           G GGA+GG   +S G   G  G      G GGG GG  G G   +    GG   GD
Sbjct: 96  GFGGASGGGYSSSGGFGGGFGG------GSGGGFGGGYGSGFGGFGGFGGGAGGGD 145



 Score = 32.0 bits (71), Expect = 3.4
 Identities = 23/67 (34%), Positives = 26/67 (38%), Gaps = 6/67 (8%)

Query: 5   GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVS 64
           G  G +GG      G   G+ G    G G  GG GG  G G      GG S G       
Sbjct: 549 GHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSG---FGGESGGSYG---G 602

Query: 65  GDEARAS 71
           G+EA  S
Sbjct: 603 GEEASGS 609



 Score = 31.6 bits (70), Expect = 4.4
 Identities = 26/65 (40%), Positives = 28/65 (43%), Gaps = 7/65 (10%)

Query: 4   CGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRAR---YDSGGVSNGDCS 60
           CGRGG  GG+   S G   G+ G   A    GG GGG  G G A    Y S G   G   
Sbjct: 61  CGRGG--GGSFGYSYGG--GSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFG 116

Query: 61  LGVSG 65
            G  G
Sbjct: 117 GGSGG 121



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 22/55 (40%), Positives = 26/55 (47%), Gaps = 4/55 (7%)

Query: 24  AKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARASPTRGPRG 78
           + GA K G+G  GG GG  G G +R  SGG   G    G  G     S +RG  G
Sbjct: 467 SSGAGKIGLGGRGGSGGSYGRG-SRGGSGGSYGGG---GSGGGYGGGSGSRGGSG 517



 Score = 31.2 bits (69), Expect = 5.8
 Identities = 19/53 (35%), Positives = 22/53 (41%), Gaps = 5/53 (9%)

Query: 5   GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNG 57
           G GG+ GG      G   G++G      G G G GG  G G      GG S G
Sbjct: 498 GGGGSGGGY-----GGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGG 545


>gi|21361472 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score = 40.8 bits (94), Expect = 0.007
 Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%)

Query: 754 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 811
           ++L +K++SG +  K    GA     DPYV + ++      + A  +TKT+ +  + P +
Sbjct: 20  RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 74

Query: 812 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 854
           +E F F++N P    + F V D++ +  D+F+GQ  +P   L T
Sbjct: 75  NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 117


>gi|222352090 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score = 40.8 bits (94), Expect = 0.007
 Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%)

Query: 754 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 811
           ++L +K++SG +  K    GA     DPYV + ++      + A  +TKT+ +  + P +
Sbjct: 12  RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 66

Query: 812 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 854
           +E F F++N P    + F V D++ +  D+F+GQ  +P   L T
Sbjct: 67  NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 109


>gi|222352088 neural precursor cell expressed, developmentally
           down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score = 40.8 bits (94), Expect = 0.007
 Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%)

Query: 754 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 811
           ++L +K++SG +  K    GA     DPYV + ++      + A  +TKT+ +  + P +
Sbjct: 12  RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 66

Query: 812 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 854
           +E F F++N P    + F V D++ +  D+F+GQ  +P   L T
Sbjct: 67  NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 109


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,024,954
Number of Sequences: 37866
Number of extensions: 2092017
Number of successful extensions: 11134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 81
Number of HSP's successfully gapped in prelim test: 195
Number of HSP's that attempted gapping in prelim test: 9089
Number of HSP's gapped (non-prelim): 1364
length of query: 1127
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1014
effective length of database: 13,968,660
effective search space: 14164221240
effective search space used: 14164221240
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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