BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] (1127 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 2279 0.0 gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 2026 0.0 gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 1410 0.0 gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 1374 0.0 gi|14249340 phospholipase C, delta 4 [Homo sapiens] 509 e-144 gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 484 e-136 gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 484 e-136 gi|19115964 phospholipase C delta 3 [Homo sapiens] 452 e-127 gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 441 e-123 gi|78499633 phospholipase C, eta 2 [Homo sapiens] 380 e-105 gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 344 3e-94 gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 344 3e-94 gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 340 3e-93 gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 336 8e-92 gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 336 8e-92 gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 326 9e-89 gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 326 9e-89 gi|95147333 phospholipase C, beta 2 [Homo sapiens] 305 2e-82 gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 218 3e-56 gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 218 3e-56 gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 213 1e-54 gi|11386139 phospholipase C beta 3 [Homo sapiens] 181 3e-45 gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 170 6e-42 gi|223633890 hypothetical protein LOC729956 [Homo sapiens] 47 1e-04 gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens] 44 9e-04 gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens] 42 0.004 gi|55956899 keratin 9 [Homo sapiens] 41 0.006 gi|21361472 neural precursor cell expressed, developmentally dow... 41 0.007 gi|222352090 neural precursor cell expressed, developmentally do... 41 0.007 gi|222352088 neural precursor cell expressed, developmentally do... 41 0.007 >gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] Length = 1127 Score = 2279 bits (5905), Expect = 0.0 Identities = 1127/1127 (100%), Positives = 1127/1127 (100%) Query: 1 MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS 60 MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS Sbjct: 1 MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS 60 Query: 61 LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK 120 LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK Sbjct: 61 LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK 120 Query: 121 TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD 180 TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD Sbjct: 121 TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD 180 Query: 181 SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN 240 SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN Sbjct: 181 SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN 240 Query: 241 IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN 300 IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN Sbjct: 241 IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN 300 Query: 301 PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT 360 PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT Sbjct: 301 PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT 360 Query: 361 KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 420 KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE Sbjct: 361 KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 420 Query: 421 HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 480 HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN Sbjct: 421 HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 480 Query: 481 EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG 540 EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG Sbjct: 481 EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG 540 Query: 541 DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN 600 DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN Sbjct: 541 DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN 600 Query: 601 MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN 660 MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN Sbjct: 601 MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN 660 Query: 661 PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ 720 PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ Sbjct: 661 PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ 720 Query: 721 NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD 780 NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD Sbjct: 721 NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD 780 Query: 781 PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE 840 PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE Sbjct: 781 PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE 840 Query: 841 FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK 900 FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK Sbjct: 841 FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK 900 Query: 901 KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM 960 KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM Sbjct: 901 KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM 960 Query: 961 LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA 1020 LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA Sbjct: 961 LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA 1020 Query: 1021 VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE 1080 VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE Sbjct: 1021 VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE 1080 Query: 1081 TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1127 TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE Sbjct: 1081 TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1127 >gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] Length = 1001 Score = 2026 bits (5248), Expect = 0.0 Identities = 1001/1001 (100%), Positives = 1001/1001 (100%) Query: 127 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 186 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI Sbjct: 1 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 60 Query: 187 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 246 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL Sbjct: 61 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 120 Query: 247 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 306 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS Sbjct: 121 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 180 Query: 307 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 366 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF Sbjct: 181 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 240 Query: 367 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 426 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ Sbjct: 241 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 300 Query: 427 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 486 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT Sbjct: 301 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 360 Query: 487 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 546 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT Sbjct: 361 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 420 Query: 547 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 606 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN Sbjct: 421 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNN 480 Query: 607 VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 666 VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN Sbjct: 481 VPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVN 540 Query: 667 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 726 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY Sbjct: 541 YNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGY 600 Query: 727 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 786 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE Sbjct: 601 VLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVE 660 Query: 787 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 846 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT Sbjct: 661 IHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYT 720 Query: 847 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 906 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA Sbjct: 721 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 780 Query: 907 SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 966 SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR Sbjct: 781 SLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPR 840 Query: 967 FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 1026 FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV Sbjct: 841 FLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIV 900 Query: 1027 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 1086 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK Sbjct: 901 HCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLK 960 Query: 1087 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1127 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE Sbjct: 961 QIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE 1001 >gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] Length = 1095 Score = 1410 bits (3649), Expect = 0.0 Identities = 715/1125 (63%), Positives = 860/1125 (76%), Gaps = 46/1125 (4%) Query: 8 GAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDE 67 GAAG P P A GG R+G A GDC SG Sbjct: 4 GAAGREDPAPPDAA-------------GGEDDPRVGPDAA---------GDCVTAASGGR 41 Query: 68 ARASPTRGPRGVALAPTPSAVVCTLPRESKPGGL------PRRSSIIKDGTKQK-RERKK 120 R + GVAL P A P +S+ G L PRRSSIIKD + QK RKK Sbjct: 42 MRDRRS----GVAL---PGAA--GTPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKK 92 Query: 121 TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD 180 TVSFSSMP+EKKISSA+DCI+ M G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD Sbjct: 93 TVSFSSMPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKD 152 Query: 181 SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN 240 EKAK+DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVAN Sbjct: 153 LEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVAN 212 Query: 241 IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN 300 IWV+GLRYL+S K LD +E +Q+ R W+ +F DVD G + +V+ I+ LN Sbjct: 213 IWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLN 272 Query: 301 PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT 360 P LK +KI LKFKE+ KSK+K T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD Sbjct: 273 PTLKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDA 332 Query: 361 KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE 420 DLM+FLEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE Sbjct: 333 NDLMLFLEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPE 392 Query: 421 HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN 480 KKV QDM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DN Sbjct: 393 QKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDN 452 Query: 481 EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG 540 EP++ + MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G Sbjct: 453 EPILCNRNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFG 512 Query: 541 DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE- 599 +KLYT +P ESYLPSP+ LK I++K KKL S+ +EG+VTDEDE AEMS+RM + Sbjct: 513 NKLYTEAPLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDY 572 Query: 600 NMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANE 659 N EQ K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E AS+ ANE Sbjct: 573 NGEQ------KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANE 626 Query: 660 NPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFR 719 P DFVNYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF Sbjct: 627 YPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFL 686 Query: 720 QNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVV 779 QNG CGYVLRP+IMR+EVS+FSANTK +PGVSP LHIKIISGQNFPKPKG+ AKGDV+ Sbjct: 687 QNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVI 746 Query: 780 DPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGD 839 DPYV +EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGD Sbjct: 747 DPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGD 806 Query: 840 EFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKG 899 EFIGQYTIPFECLQ GYRHVPL+S G+++ H +LFVH+AITNR GGGK KR LSVR G Sbjct: 807 EFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMG 866 Query: 900 KKSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQC 959 KK REY LR + +KT+D++FK A P+R+A D+RENMQNA+VS KELCGL +A+L QC Sbjct: 867 KKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQC 926 Query: 960 MLAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENAD 1019 +L +S R + DNTP V L + + +P +E G +P+V KK++T YD+MIQ + LIE AD Sbjct: 927 LLTLSSRLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMAD 986 Query: 1020 AVYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKN 1079 V EKIV CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKN Sbjct: 987 TVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKN 1046 Query: 1080 ETLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 1124 E +EN+KQI A +SCGL+K + +A+ K +RSLE I EK + E Sbjct: 1047 EAIENMKQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 1090 >gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] Length = 997 Score = 1374 bits (3556), Expect = 0.0 Identities = 667/999 (66%), Positives = 807/999 (80%), Gaps = 8/999 (0%) Query: 127 MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKI 186 MP+EKKISSA+DCI+ M G ELKKVR NSRIY+R+F LD D+Q+LRWEPSKKD EKAK+ Sbjct: 1 MPSEKKISSANDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKL 60 Query: 187 DIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGL 246 DI +IKE+R GKNT+ FR+NG++DQI EDCAFS+++GENYESLDLVANSADVANIWV+GL Sbjct: 61 DISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGL 120 Query: 247 RYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTS 306 RYL+S K LD +E +Q+ R W+ +F DVD G + +V+ I+ LNP LK + Sbjct: 121 RYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEA 180 Query: 307 KIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMF 366 KI LKFKE+ KSK+K T VT+EEF E F ELCTRPE+YFLLVQ S NKE+LD DLM+F Sbjct: 181 KIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLF 240 Query: 367 LEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQ 426 LEAEQGV HI E+I L+II +YE S+EG++KG+L+IDGFT YL+S +C IFDPE KKV Q Sbjct: 241 LEAEQGVTHITEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQ 300 Query: 427 DMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYT 486 DM QPLSHY+IN+SHNTYLIEDQFRGP+DI GYIRALKMGCRSVELDV DG DNEP++ Sbjct: 301 DMTQPLSHYYINASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCN 360 Query: 487 GHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTT 546 + MT+ + FRSVI++INK+AF ASEYPLILCL NHCS+ QQKVM Q MKK+ G+KLYT Sbjct: 361 RNNMTTHVSFRSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTE 420 Query: 547 SPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKE-NMEQPN 605 +P ESYLPSP+ LK I++K KKL S+ +EG+VTDEDE AEMS+RM + N EQ Sbjct: 421 APLPSESYLPSPEKLKRMIIVKGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQ-- 478 Query: 606 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 665 K+ +LC+ELS+LVSICKSVQ+++F++S + Q YWE+CSF+E AS+ ANE P DFV Sbjct: 479 ----KQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWEMCSFSETEASRIANEYPEDFV 534 Query: 666 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 725 NYNK+FL+R++PS MRIDSSN+NPQDFW CGCQIVAMNFQTPG MMDL+ GWF QNG CG Sbjct: 535 NYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCG 594 Query: 726 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785 YVLRP+IMR+EVS+FSANTK +PGVSP LHIKIISGQNFPKPKG+ AKGDV+DPYV + Sbjct: 595 YVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCI 654 Query: 786 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQY 845 EIHGIPADC+EQRTKTV QN D PIFDE+FEFQ+NLPELAM+RFVVLDDDYIGDEFIGQY Sbjct: 655 EIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQY 714 Query: 846 TIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREY 905 TIPFECLQ GYRHVPL+S G+++ H +LFVH+AITNR GGGK KR LSVR GKK REY Sbjct: 715 TIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREY 774 Query: 906 ASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSP 965 LR + +KT+D++FK A P+R+A D+RENMQNA+VS KELCGL +A+L QC+L +S Sbjct: 775 TMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSIKELCGLPPIASLKQCLLTLSS 834 Query: 966 RFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKI 1025 R + DNTP V L + + +P +E G +P+V KK++T YD+MIQ + LIE AD V EKI Sbjct: 835 RLITSDNTPSVSLVMKDSFPYLEPLGAIPDVQKKMLTAYDLMIQESRFLIEMADTVQEKI 894 Query: 1026 VHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENL 1085 V CQKA MEFHE LH++G KEGLK RKL KA ESF WNIT+LKGQ DLLK AKNE +EN+ Sbjct: 895 VQCQKAGMEFHEELHNLGAKEGLKGRKLNKATESFAWNITVLKGQGDLLKNAKNEAIENM 954 Query: 1086 KQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDE 1124 KQI A +SCGL+K + +A+ K +RSLE I EK + E Sbjct: 955 KQIQLACLSCGLSKAPSSSAEA-KSKRSLEAIEEKESSE 992 >gi|14249340 phospholipase C, delta 4 [Homo sapiens] Length = 762 Score = 509 bits (1312), Expect = e-144 Identities = 294/756 (38%), Positives = 436/756 (57%), Gaps = 38/756 (5%) Query: 143 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 202 M EG ++KVRS S RYF L D ++ + S K I ++ +R G ++++ Sbjct: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSEL 77 Query: 203 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262 RS +++++ + F++++ +LDL+ANS + A IW+ GL+ L+ D++ S Sbjct: 78 LRS--LAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLV-------DLVTS 128 Query: 263 SQDNMRTS-WVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDK 321 R W+S F D + G ++ + + +N + E F + Sbjct: 129 MDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQ---EYAFSLFQAADTS 185 Query: 322 AGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEIS 381 + EEF++ + L R E+ L FS++ + L + + FL+ EQ E++ Sbjct: 186 QSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELA 245 Query: 382 LEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSH 441 LE+I +YEPS G+ + LS+DGF +YL S D IF+P + QDM QPL+HYFI SSH Sbjct: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305 Query: 442 NTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVID 501 NTYL+ DQ G S + GYIRALK GCR VE+DVWDGP EPV+Y GHT+TS+I+F+ V+ Sbjct: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVA 365 Query: 502 IINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLY-TTSPNVEESYLPSPDV 560 + +YAF S+YP+IL LE HCS +QQ+ M +H+ ++LG++L TT V + LPSP+ Sbjct: 366 TVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEE 425 Query: 561 LKGKILIKAKKLSSNCSGVEGDVTDEDEGA---------------EMSQRMGKENMEQPN 605 L+ KIL+K KKL+ +E D+ E+E A E ++N++ + Sbjct: 426 LRRKILVKGKKLT-----LEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKD 480 Query: 606 NVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFV 665 + LC LS LV KSV F+ F S + ++E+ SF+E A + E +FV Sbjct: 481 KKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFV 540 Query: 666 NYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCG 725 +N L+RV+PS +R DSSN NPQ+ W GCQ+VAMN QT GL MD+ G FRQNG CG Sbjct: 541 QHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCG 600 Query: 726 YVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785 YVL+P +R+ S F + + + Q L I++ISGQ PK + +G +VDP V V Sbjct: 601 YVLKPDFLRDIQSSF--HPEKPISPFKAQTLLIQVISGQQLPKVDKT-KEGSIVDPLVKV 657 Query: 786 EIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQ 844 +I G+ D A Q T V NG P + ++ F++ +PELAM+RFVV+D D+ ++FIGQ Sbjct: 658 QIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQ 717 Query: 845 YTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 YT+P+ C+Q GYRH+ L S G L AS+FV++ I Sbjct: 718 YTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICI 753 >gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] Length = 756 Score = 484 bits (1247), Expect = e-136 Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%) Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 196 + ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR Sbjct: 19 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77 Query: 197 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 256 G T+ + + ED FS+++ + +LDL+A S A WV GL +I + + Sbjct: 78 GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 134 Query: 257 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 316 +D + Q W+ + D + ++ ++ LN + S F+E Sbjct: 135 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 188 Query: 317 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 375 D + T+ ++E IE F+++ T R EI + + + E L L+ FL+ +Q Sbjct: 189 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 245 Query: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 435 ++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY Sbjct: 246 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 305 Query: 436 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 495 ++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+ Sbjct: 306 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 365 Query: 496 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 555 F V+ I YAF AS YP+IL LENHC+++QQ+VM +H+ +LG L + + L Sbjct: 366 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 425 Query: 556 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 609 PSP+ LKGKIL+K KKL G EG V+DEDE AEM + ++ + Sbjct: 426 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 483 Query: 610 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 668 + +L +ELS++V CKSV F F Q ++E+ SF+E A + E+ FV +N Sbjct: 484 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 543 Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728 L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ G F+ NG CGYVL Sbjct: 544 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 603 Query: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788 +PA +R+ F+ P + + L+I++ISGQ PK + K +VDP V VEIH Sbjct: 604 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 661 Query: 789 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 847 G+ D A ++T + NG P +D F F++ +P+LA++RF+V D D ++FIGQ TI Sbjct: 662 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 721 Query: 848 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 P L+ GYRHV L S G+ A+LFV +++ Sbjct: 722 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 754 >gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] Length = 777 Score = 484 bits (1247), Expect = e-136 Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%) Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 196 + ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR Sbjct: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98 Query: 197 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 256 G T+ + + ED FS+++ + +LDL+A S A WV GL +I + + Sbjct: 99 GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 155 Query: 257 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 316 +D + Q W+ + D + ++ ++ LN + S F+E Sbjct: 156 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 209 Query: 317 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 375 D + T+ ++E IE F+++ T R EI + + + E L L+ FL+ +Q Sbjct: 210 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 266 Query: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 435 ++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY Sbjct: 267 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 326 Query: 436 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 495 ++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+ Sbjct: 327 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 386 Query: 496 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 555 F V+ I YAF AS YP+IL LENHC+++QQ+VM +H+ +LG L + + L Sbjct: 387 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 446 Query: 556 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 609 PSP+ LKGKIL+K KKL G EG V+DEDE AEM + ++ + Sbjct: 447 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 504 Query: 610 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 668 + +L +ELS++V CKSV F F Q ++E+ SF+E A + E+ FV +N Sbjct: 505 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 564 Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728 L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ G F+ NG CGYVL Sbjct: 565 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 624 Query: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788 +PA +R+ F+ P + + L+I++ISGQ PK + K +VDP V VEIH Sbjct: 625 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 682 Query: 789 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 847 G+ D A ++T + NG P +D F F++ +P+LA++RF+V D D ++FIGQ TI Sbjct: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742 Query: 848 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 P L+ GYRHV L S G+ A+LFV +++ Sbjct: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775 >gi|19115964 phospholipase C delta 3 [Homo sapiens] Length = 789 Score = 452 bits (1163), Expect = e-127 Identities = 279/750 (37%), Positives = 408/750 (54%), Gaps = 34/750 (4%) Query: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKID-IKSIKEVRTGK 198 + +M+ GS L+K+RS + R + L D S+ ++ + I ++ I+ VR G Sbjct: 62 VRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGH 121 Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258 ++ R G + ++ + ++LDL A +A+ A WV GL L + LD Sbjct: 122 QSEGLRRFG--GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL----RARLD 175 Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKEL-HK 317 + SQ W+ D + ++ +R +N + L FKE H Sbjct: 176 AM--SQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHS 233 Query: 318 SKDKA-GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHI 376 + D+ G E+ EEF+ L RPE+ + Q+S L +L+ FLE +QG Sbjct: 234 NNDRLEGAEI--EEFLR---RLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGA 287 Query: 377 NEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYF 436 + ++I YE ++ ++ +++DGF YL+SP+ D H V QDM QPL+HYF Sbjct: 288 TLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYF 347 Query: 437 INSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVF 496 I+SSHNTYL + Q GPS Y+RA GCR VELD W+GP EPVIY GHT+TS+I+F Sbjct: 348 ISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILF 407 Query: 497 RSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT---TSPNVEES 553 R V+ + +AF S YP+IL LENHC ++QQ M +H+ +LGD L T SPN EE Sbjct: 408 RDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEE- 466 Query: 554 YLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRF- 612 LPSP+ LKG++L+K KKL + S ++D +E E + E E+ +R Sbjct: 467 -LPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDE----EEEEEVEAAAQRRLA 521 Query: 613 -QLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRF 671 Q+ ELS L C + + + + + +V S +E A K E FV +N R Sbjct: 522 KQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQ 581 Query: 672 LARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPA 731 L RV+P +R++S+N +PQ+ W GCQ+VA+NFQTPG MDLN G F NG CGYVL+PA Sbjct: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641 Query: 732 IMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIP 791 +R+ S F PG L I++++ Q PK + +VDP V +EIHG+P Sbjct: 642 CLRQPDSTFD----PEYPGPPRTTLSIQVLTAQQLPK-LNAEKPHSIVDPLVRIEIHGVP 696 Query: 792 ADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFE 850 ADCA Q T V NG P + ++ +FQ+ PELA+VRFVV D D ++F+GQ+T+P Sbjct: 697 ADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLS 756 Query: 851 CLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 L+ GYRH+ L S G L+ A+LF+ + I Sbjct: 757 SLKQGYRHIHLLSKDGASLSPATLFIQIRI 786 >gi|25188201 phospholipase C, zeta 1 [Homo sapiens] Length = 608 Score = 441 bits (1134), Expect = e-123 Identities = 238/576 (41%), Positives = 354/576 (61%), Gaps = 22/576 (3%) Query: 313 KELHKSKDKAGT-EVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQ 371 K++ K D+ +T EEF ++ + R EI + +S N++ L +L FL EQ Sbjct: 41 KQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQ 100 Query: 372 GVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQP 431 A +++ I+ EII KYEP +E ++ +S++GFT Y+ S +C +F E +KV QDM P Sbjct: 101 YAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHP 160 Query: 432 LSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMT 491 L+ YFI+SSHNTYL+ DQ GPSD+ GY+ AL GCR +E+D WDG NEPV+Y G+T+T Sbjct: 161 LNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDGAQNEPVVYHGYTLT 220 Query: 492 SQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVE 551 S+++F++VI I+KYAF S+YP++L LENHCS QQ+VM +++ G+ L + + Sbjct: 221 SKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDF 280 Query: 552 ESYLPSPDVLKGKILIKAKKLSS-------NCSGVEGDVTDEDEGAEMSQRMGKENMEQP 604 LPSP+ LK KIL+K KK+ + S GD D++ G + + ++ Sbjct: 281 PDTLPSPEALKFKILVKNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKK- 339 Query: 605 NNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDF 664 ++ ++ LS+LV K+ +FK FQ S Q++ E S E A K + +F Sbjct: 340 ----TRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEF 395 Query: 665 VNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNC 724 + + ++F+ R++P R DSSN NPQ+FW GCQ+VA+NFQTPGL MDL G F NG Sbjct: 396 IFHTRKFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGS 455 Query: 725 GYVLRPAIMREEVSFFS-ANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYV 783 GY+L+P +RE S+F+ +N K+ + P L I++ISG P S KGD + V Sbjct: 456 GYILKPHFLRESKSYFNPSNIKEGM----PITLTIRLISGIQLPLTHSSSNKGDSL---V 508 Query: 784 YVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYI-GDEFI 842 +E+ G+P D +Q+T+ + +N +P ++E+F F I++PELA++RFVV I G+EF+ Sbjct: 509 IIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFL 568 Query: 843 GQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHV 878 GQYT+P C+ GYR +PL S GE L ASLFV+V Sbjct: 569 GQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604 >gi|78499633 phospholipase C, eta 2 [Homo sapiens] Length = 1416 Score = 380 bits (976), Expect = e-105 Identities = 204/457 (44%), Positives = 291/457 (63%), Gaps = 9/457 (1%) Query: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198 C+ +M EG ++ K+R S+ R++ LD +RW PS+K+ EKAKI I SI+EV G+ Sbjct: 45 CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103 Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258 +++F+ +C FS+ +G + ESLDLV+ S++VA WVTGLRYL++ G D Sbjct: 104 QSEVFQRYP-DGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMA-GISDED 161 Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318 L Q R W+ Q F E D + G +++ +Q + LN L +++ F+E + Sbjct: 162 SLARRQ-RTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD-T 219 Query: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378 D GT + EEF + + TR ++Y L++ +S++K+ LD L FL+ EQ +A + Sbjct: 220 DDHQGT-LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTL 278 Query: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438 E +II ++EP E + KG L IDGFTNY SP IF+PEH V QDM QPLSHYFI Sbjct: 279 ESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFIT 338 Query: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498 SSHNTYL+ DQ S + Y L+ GCR VE+D WDGPD EP+++ G+T+TS+I+F+ Sbjct: 339 SSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKD 398 Query: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557 VI+ INKYAF +EYP+IL +ENHCS+ QQK M Q++ +LGDKL +S + E+ + LPS Sbjct: 399 VIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPS 458 Query: 558 PDVLKGKILIKAKKLSSNCS--GVEGDVTDEDEGAEM 592 P +LKGKIL+K KKL +N S EG+V+DED E+ Sbjct: 459 PQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEI 495 Score = 241 bits (616), Expect = 2e-63 Identities = 129/320 (40%), Positives = 193/320 (60%), Gaps = 21/320 (6%) Query: 568 KAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKS 627 K KL S EGD + G Q G + K +L + LS+LV KS Sbjct: 586 KGSKLKKAASVEEGDEGQDSPGG---QSRGATRQK-------KTMKLSRALSDLVKYTKS 635 Query: 628 VQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNM 687 V + ++ + W+V SF+E A + + P ++ +N++ L+R++PS R+DSSN Sbjct: 636 VATHDIEM--EAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNY 693 Query: 688 NPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDS 747 NPQ FW GCQ+VA+N+Q+ G M+ LN F NG CGYVL+P M + V F+ N++D Sbjct: 694 NPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDP 751 Query: 748 VPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQN 805 +PG + L ++IISGQ PKP+ S G +G+++DP+V VEI G+P DC+ ++T+ V N Sbjct: 752 LPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDN 811 Query: 806 GDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLT 865 G P ++E+ F +++PE+A+VRF+V D D IG +FIGQ T+ F + GYRHV L Sbjct: 812 GFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL---- 867 Query: 866 GEVLAHASLFVHVAITNRRG 885 E + AS+FVHVA+++ G Sbjct: 868 -EGMEEASIFVHVAVSDISG 886 >gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] Length = 1002 Score = 344 bits (882), Expect = 3e-94 Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%) Query: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198 C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ Sbjct: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76 Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258 ++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D Sbjct: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134 Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318 L Q WV Q F E D + G + + Q + LN L K+ F+E Sbjct: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193 Query: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378 +++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ Sbjct: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251 Query: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438 + L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311 Query: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498 SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371 Query: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557 V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431 Query: 558 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592 P LKGKIL+K KKL + EG+V+DED E+ Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468 Score = 227 bits (578), Expect = 6e-59 Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%) Query: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620 GK K S + S + + T + G E Q R+G+ K +LC+ELS+ Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603 Query: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680 LV SV ++ V SF+E A + + F+ YN++ L R++PS Sbjct: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 Query: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740 RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718 Query: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798 + + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + + Sbjct: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778 Query: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858 T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH Sbjct: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838 Query: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 889 V L+ LT AS+FVH+ I G P Sbjct: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864 >gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] Length = 1693 Score = 344 bits (882), Expect = 3e-94 Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%) Query: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198 C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ Sbjct: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76 Query: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258 ++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D Sbjct: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134 Query: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318 L Q WV Q F E D + G + + Q + LN L K+ F+E Sbjct: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193 Query: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378 +++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ Sbjct: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251 Query: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438 + L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I Sbjct: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311 Query: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498 SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR Sbjct: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371 Query: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557 V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS Sbjct: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431 Query: 558 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592 P LKGKIL+K KKL + EG+V+DED E+ Sbjct: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468 Score = 227 bits (578), Expect = 6e-59 Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%) Query: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620 GK K S + S + + T + G E Q R+G+ K +LC+ELS+ Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603 Query: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680 LV SV ++ V SF+E A + + F+ YN++ L R++PS Sbjct: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 Query: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740 RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718 Query: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798 + + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + + Sbjct: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778 Query: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858 T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH Sbjct: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838 Query: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 889 V L+ LT AS+FVH+ I G P Sbjct: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864 >gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] Length = 1655 Score = 340 bits (873), Expect = 3e-93 Identities = 188/453 (41%), Positives = 276/453 (60%), Gaps = 9/453 (1%) Query: 143 MVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDI 202 M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ ++I Sbjct: 4 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGRQSEI 62 Query: 203 FRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262 F C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D L Sbjct: 63 FHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDEDSLAK 120 Query: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322 Q WV Q F E D + G + + Q + LN L K+ F+E +++ Sbjct: 121 RQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ- 178 Query: 323 GTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISL 382 GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ + L Sbjct: 179 GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCL 237 Query: 383 EIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHN 442 +II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I SSHN Sbjct: 238 DIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHN 297 Query: 443 TYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDI 502 TYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR V++ Sbjct: 298 TYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVET 357 Query: 503 INKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPSPDVL 561 INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPSP L Sbjct: 358 INKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSL 417 Query: 562 KGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592 KGKIL+K KKL + EG+V+DED E+ Sbjct: 418 KGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 450 Score = 226 bits (577), Expect = 7e-59 Identities = 135/349 (38%), Positives = 195/349 (55%), Gaps = 24/349 (6%) Query: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620 GK K S + S + + T + G E Q R+G+ K +LC+ELS+ Sbjct: 535 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 585 Query: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680 LV SV ++ V SF+E A + + F+ YN++ L R++PS Sbjct: 586 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 642 Query: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740 RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F Sbjct: 643 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 700 Query: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798 + + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + + Sbjct: 701 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 760 Query: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858 T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH Sbjct: 761 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 820 Query: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYAS 907 V L+ LT AS+FVH+ I N G +GL K R +S Sbjct: 821 VYLEGLT-----EASIFVHITI-NEIYGKNRQLQGLKGLFNKNPRHSSS 863 >gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] Length = 1194 Score = 336 bits (861), Expect = 8e-92 Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%) Query: 145 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 197 EG+ + S ++ L D L W K+ + + + I +R+G Sbjct: 19 EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76 Query: 198 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 253 K + G S+ E V G + ++ +VA + +V WV GLR +I Sbjct: 77 PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134 Query: 254 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 310 N R + VS M + L +T N +R++ + K E Sbjct: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182 Query: 311 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 363 KEL K+ + T + E+F E+ ++C R +I L + + +K ++L L Sbjct: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242 Query: 364 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 415 + FL Q +NE + +++II YEP ++ ++KG +S DGF YLMS + Sbjct: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302 Query: 416 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 475 + ++ Q+M PL+HYFI+SSHNTYL QF G S + Y + L GCR VELD W Sbjct: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362 Query: 476 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 533 D G D EP+I G M + I+F+ VI I + AF SEYP+IL ENHCS QQ M + Sbjct: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422 Query: 534 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 572 + + L GD L + P LPSP+ LK KILIK K+L Sbjct: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482 Query: 573 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 609 +S + +E D +E E A+ + + G E N + V V Sbjct: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542 Query: 610 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 655 + Q + LS +++ + V+F+ F V+ + ++ + SFNE + Sbjct: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602 Query: 656 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 715 Y + +FVNYNKR ++R++P R+DSSN PQ FW GCQ+V++N+QTP L M LN Sbjct: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662 Query: 716 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 775 G F NG+CGY+L+P MR F ++ V GV +++ISGQ K Sbjct: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717 Query: 776 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 831 + YV V+++G+P D E RT+ V NG P++ +ESF F ++ LP+LA++R V Sbjct: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774 Query: 832 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 DD+ ++ IGQ +P + LQ GYRH+ L++ + L+ ++F ++ + Sbjct: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820 >gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] Length = 1175 Score = 336 bits (861), Expect = 8e-92 Identities = 259/829 (31%), Positives = 400/829 (48%), Gaps = 120/829 (14%) Query: 145 EGSELKKVRSNSRIYHRYFLLDADMQS--LRWEPSKKDSEKAKIDIKSIKEVRTG----- 197 EG+ + S ++ L D L W K+ + + + I +R+G Sbjct: 19 EGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSL--INSIRSGAIPKD 76 Query: 198 -KNTDIFRSNGISDQISEDCAFSVIYGENYESLD---LVANSADVANIWVTGLRYLISYG 253 K + G S+ E V G + ++ +VA + +V WV GLR +I Sbjct: 77 PKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIH-- 134 Query: 254 KHTLDMLESSQDNMRTSWVSQMFS-EIDVDNLGHITLCNAVQCIRNLNPGLKTSKIEL-- 310 N R + VS M + L +T N +R++ + K E Sbjct: 135 ------------NFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVI 182 Query: 311 --KFKELH----KSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK-EFLDTKDL 363 KEL K+ + T + E+F E+ ++C R +I L + + +K ++L L Sbjct: 183 FQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQL 242 Query: 364 MMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCY 415 + FL Q +NE + +++II YEP ++ ++KG +S DGF YLMS + Sbjct: 243 VSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENA 302 Query: 416 IFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVW 475 + ++ Q+M PL+HYFI+SSHNTYL QF G S + Y + L GCR VELD W Sbjct: 303 PVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCW 362 Query: 476 D--GPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQ 533 D G D EP+I G M + I+F+ VI I + AF SEYP+IL ENHCS QQ M + Sbjct: 363 DGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSK 422 Query: 534 HMKKLLGDKL----YTTSPNVEESYLPSPDVLKGKILIKAKKL----------------- 572 + + L GD L + P LPSP+ LK KILIK K+L Sbjct: 423 YCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMME 482 Query: 573 ----SSNCSGVEGDVTDEDEGAEMSQ------RMGKE-------------NMEQPNNVPV 609 +S + +E D +E E A+ + + G E N + V V Sbjct: 483 AGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTV 542 Query: 610 KRFQ--------------LCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASK 655 + Q + LS +++ + V+F+ F V+ + ++ + SFNE + Sbjct: 543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLG 602 Query: 656 YANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNI 715 Y + +FVNYNKR ++R++P R+DSSN PQ FW GCQ+V++N+QTP L M LN Sbjct: 603 YLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQ 662 Query: 716 GWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAK 775 G F NG+CGY+L+P MR F ++ V GV +++ISGQ K Sbjct: 663 GKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKK----- 717 Query: 776 GDVVDPYVYVEIHGIPADC--AEQRTKTVHQNGDAPIF-DESFEF-QINLPELAMVRFVV 831 + YV V+++G+P D E RT+ V NG P++ +ESF F ++ LP+LA++R V Sbjct: 718 ---IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAV 774 Query: 832 LDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 DD+ ++ IGQ +P + LQ GYRH+ L++ + L+ ++F ++ + Sbjct: 775 YDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVL 820 >gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform a [Homo sapiens] Length = 1216 Score = 326 bits (835), Expect = 9e-89 Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%) Query: 141 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 200 +S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++ Sbjct: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78 Query: 201 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 250 + + + + E +V+YG N L+LVA +VA W + L Sbjct: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138 Query: 251 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 308 + ++L +Q+ R +++ + ++++ V G I L N R + K + Sbjct: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187 Query: 309 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 365 L+ L S++ + + T E + + LC RPEI + +F + +K +L +M Sbjct: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247 Query: 366 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 417 F+ +Q +NE E +I KYEP+ KG +S+DGF YL + + Sbjct: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307 Query: 418 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 477 PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G Sbjct: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367 Query: 478 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 534 + EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++ Sbjct: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427 Query: 535 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 580 + + GD L P LPSP L KIL+K KK S S SG + Sbjct: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487 Query: 581 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 623 G+ E + + K +M++ +E+S LV+ Sbjct: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545 Query: 624 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 683 + V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D Sbjct: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605 Query: 684 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 743 SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F Sbjct: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665 Query: 744 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 801 T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT Sbjct: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717 Query: 802 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858 N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY + Sbjct: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773 Query: 859 VPLQSLTGEVLAHASLFVHVAI 880 + L++ + L ++FV++ + Sbjct: 774 ICLRNERNQPLTLPAVFVYIEV 795 >gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform b [Homo sapiens] Length = 1173 Score = 326 bits (835), Expect = 9e-89 Identities = 247/802 (30%), Positives = 392/802 (48%), Gaps = 88/802 (10%) Query: 141 NSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNT 200 +S+ +G++ K +S I +L D Q + + ++ E +D+ +K+ R G++ Sbjct: 20 DSLKKGTKFVKWDDDSTIVTP-IILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHA 78 Query: 201 DIFRSNGISDQIS-------EDCAFSVIYGE---NYESLDLVANSADVANIWVTGLRYLI 250 + + + + E +V+YG N L+LVA +VA W + L Sbjct: 79 KAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLA 138 Query: 251 SYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNAVQCIRNLNPGLKTSKI 308 + ++L +Q+ R +++ + ++++ V G I L N R + K + Sbjct: 139 T------NLL--AQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIY---RLFSADRKRVET 187 Query: 309 ELKFKELHKSKDKA--GTEVTKEEFIEVFHELCTRPEIYFLLVQFSS-NKEFLDTKDLMM 365 L+ L S++ + + T E + + LC RPEI + +F + +K +L +M Sbjct: 188 ALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMD 247 Query: 366 FLEAEQGVAHINE--------EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF 417 F+ +Q +NE E +I KYEP+ KG +S+DGF YL + + Sbjct: 248 FINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVV 307 Query: 418 DPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDG 477 PE + +DM QPLSHYFINSSHNTYL Q G S + Y + L GCR VELD W G Sbjct: 308 SPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKG 367 Query: 478 --PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHC-SIKQQKVMVQH 534 + EPVI G TMT++I F+ VI+ I + AF S +P++L ENH S KQQ M ++ Sbjct: 368 RTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEY 427 Query: 535 MKKLLGDKLYTTS----PNVEESYLPSPDVLKGKILIKAKKLS---SNCSGVE------- 580 + + GD L P LPSP L KIL+K KK S S SG + Sbjct: 428 CRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQAS 487 Query: 581 -----------------GDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVS 623 G+ E + + K +M++ +E+S LV+ Sbjct: 488 NTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDE--GTAGSEAMATEEMSNLVN 545 Query: 624 ICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRID 683 + V+F+ F++S + K +E+ SF E + ++P +FV YNK L+R++P R+D Sbjct: 546 YIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVD 605 Query: 684 SSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSAN 743 SSN PQ FW GCQ+VA+NFQT L M +N+G + NG GY L+P MR F Sbjct: 606 SSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPF 665 Query: 744 TKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ--RTKT 801 T+ V G+ L +KIISGQ K V YV V++ G+P D + +TKT Sbjct: 666 TEGIVDGIVANTLSVKIISGQFLSDKK--------VGTYVEVDMFGLPVDTRRKAFKTKT 717 Query: 802 VHQNGDAPIFDES---FEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858 N P+++E F+ ++ LP LA +R V ++ G +FIG +P + ++ GY + Sbjct: 718 SQGNAVNPVWEEEPIVFK-KVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHY 773 Query: 859 VPLQSLTGEVLAHASLFVHVAI 880 + L++ + L ++FV++ + Sbjct: 774 ICLRNERNQPLTLPAVFVYIEV 795 >gi|95147333 phospholipase C, beta 2 [Homo sapiens] Length = 1185 Score = 305 bits (780), Expect = 2e-82 Identities = 246/778 (31%), Positives = 374/778 (48%), Gaps = 100/778 (12%) Query: 172 LRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDC--------AFSVIYG 223 L W K+ E +DI SI++ R GK + +S + D + D +V+ G Sbjct: 47 LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104 Query: 224 ENYESL---DLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI- 279 + L + V+ +V W + L+ KH L S R++++ ++ ++ Sbjct: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPLTANAS-----RSTFLDKILVKLK 156 Query: 280 -DVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHE- 337 +++ G I + N Q ++E H K K + E+F E ++ Sbjct: 157 MQLNSEGKIPVKNFFQMFP-----ADRKRVEAALSACHLPKGK-NDAINPEDFPEPVYKS 210 Query: 338 ----LCTRPEIYFLLVQFSSN-KEFLDTKDLMMFLEAEQGVAHINEEISLE--------I 384 LC RPEI + + + K ++ + L F+ +Q + +N + + Sbjct: 211 FLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGL 270 Query: 385 IHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTY 444 I KYEPS ++G LS +G +L P+ + + + DM QPL+HYFINSSHNTY Sbjct: 271 IDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTY 330 Query: 445 LIEDQFRGPSDITGYIRALKMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDI 502 L QF G S Y + L GCR VELD W G PD EP+I G TMT+ I F+ I+ Sbjct: 331 LTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEA 390 Query: 503 INKYAFFASEYPLILCLENHC-SIKQQKVMVQHMKKLLGDKLYTTS----PNVEESYLPS 557 I + AF S YP+IL ENH S +QQ M ++ + + GD L T P LPS Sbjct: 391 IAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPS 450 Query: 558 PDVLKGKILIKAKK-------LSSNCSGVE-------------GDVTDEDEGAEMSQR-M 596 P+ L+GKILIK KK SS +G E G V +EG E+ + + Sbjct: 451 PEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEV 510 Query: 597 GKENMEQPNNVP---VKRFQ-----------LCKELSELVSICKSVQFKEFQVSFQVQKY 642 +E E+ N+ +K+ Q +E+S LV+ + +F F+ S Q + Sbjct: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570 Query: 643 WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 702 + + SF E+ A ++ FV+YNKR ++R++P R+DSSN PQ FW GCQ+VA+ Sbjct: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630 Query: 703 NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 762 NFQT L M N+ F NG GY+L+ MR F+ + D + V L I +IS Sbjct: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690 Query: 763 GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTK-TVHQNGDAPIF-DESFEFQ- 818 GQ + V YV VE+ G+P D + RTK + N P++ +E F F+ Sbjct: 691 GQFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEK 742 Query: 819 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876 I +PELA +R V+++ G++F+G IP L +GY H+ L S + L +LF+ Sbjct: 743 ILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797 >gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] Length = 1291 Score = 218 bits (554), Expect = 3e-56 Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%) Query: 153 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 212 + + R + F + + + + W E A IDI+ IKE+R GK + F D+ Sbjct: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93 Query: 213 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262 ED AF ++YG + ++L L A S D N+W+ GL +L+ D L++ Sbjct: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147 Query: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322 W+ + F +D + I+ + + +N + + +E ++ Sbjct: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204 Query: 323 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 373 ++T +F +++ L P + ++ E + + FL QG Sbjct: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264 Query: 374 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 429 + + ++ + +P +E +E + +D F +L S + +++ + VC D M Sbjct: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323 Query: 430 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 489 PLSHY+I+SSHNTYL DQF S + Y R L+MGCR +ELD WDGPD PVIY GHT Sbjct: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383 Query: 490 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 549 +T++I F V+ I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T Sbjct: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443 Query: 550 VEESYLPSPDVLKGKILIKAKKLS 573 + LPSP+ LK KILIK KKL+ Sbjct: 444 ISADGLPSPNQLKRKILIKHKKLA 467 Score = 187 bits (475), Expect = 5e-47 Identities = 108/274 (39%), Positives = 162/274 (59%), Gaps = 10/274 (3%) Query: 610 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 668 +R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN Sbjct: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004 Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728 + L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N F +CGYVL Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064 Query: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788 +P+ MR+E F K S+ G+ P + I+++ ++ PK G G +V P+V +E+ Sbjct: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117 Query: 789 GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 846 G D +Q+T+ V NG P++ + F FQI+ PE A +RFVV ++D D+ F+ Q T Sbjct: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177 Query: 847 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880 P + L+TGYR VPL++ E L ASL + + I Sbjct: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211 >gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] Length = 1290 Score = 218 bits (554), Expect = 3e-56 Identities = 143/444 (32%), Positives = 225/444 (50%), Gaps = 40/444 (9%) Query: 153 RSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQI 212 + + R + F + + + + W E A IDI+ IKE+R GK + F D+ Sbjct: 41 KKSQRPERKTFQVKLETRQITWSRGADKIEGA-IDIREIKEIRPGKTSRDF------DRY 93 Query: 213 SEDCAFS--------VIYGENY--ESLDLVANSADVANIWVTGLRYLISYGKHTLDMLES 262 ED AF ++YG + ++L L A S D N+W+ GL +L+ D L++ Sbjct: 94 QEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLME------DTLQA 147 Query: 263 SQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKA 322 W+ + F +D + I+ + + +N + + +E ++ Sbjct: 148 PTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRF---LRERLTDLEQR 204 Query: 323 GTEVTKEEFIEVFHELCTR-------PEIYFLLVQFSSNKEF--LDTKDLMMFLEAEQGV 373 ++T +F +++ L P + ++ E + + FL QG Sbjct: 205 SGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGE 264 Query: 374 AHINEEISLE---IIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQD-MK 429 + + ++ + +P +E +E + +D F +L S + +++ + VC D M Sbjct: 265 LWAVDRLQVQEFMLSFLRDPLREIEEP-YFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323 Query: 430 QPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHT 489 PLSHY+I+SSHNTYL DQF S + Y R L+MGCR +ELD WDGPD PVIY GHT Sbjct: 324 NPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHT 383 Query: 490 MTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPN 549 +T++I F V+ I ++AF ASEYP+IL +E+HCSI QQ+ M Q+ KK+LGD L T Sbjct: 384 LTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVE 443 Query: 550 VEESYLPSPDVLKGKILIKAKKLS 573 + LPSP+ LK KILIK KKL+ Sbjct: 444 ISADGLPSPNQLKRKILIKHKKLA 467 Score = 188 bits (477), Expect = 3e-47 Identities = 115/301 (38%), Positives = 170/301 (56%), Gaps = 15/301 (4%) Query: 610 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGD-FVNYN 668 +R ++ ELSELV C+ V F E ++ + Y ++ SF E A KY N+ G F+ YN Sbjct: 945 RRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYN 1004 Query: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728 + L+R++P R+DSSN +P W CG Q+VA+NFQTP M +N F +CGYVL Sbjct: 1005 RLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVL 1064 Query: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788 +P+ MR+E F K S+ G+ P + I+++ ++ PK G G +V P+V +E+ Sbjct: 1065 QPSTMRDEA--FDPFDKSSLRGLEPCAISIEVLGARHLPK-NGRG----IVCPFVEIEVA 1117 Query: 789 GIPADCAEQRTKTVHQNGDAPIFD-ESFEFQINLPELAMVRFVVLDDDYIGDE-FIGQYT 846 G D +Q+T+ V NG P++ + F FQI+ PE A +RFVV ++D D+ F+ Q T Sbjct: 1118 GAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQAT 1177 Query: 847 IPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYA 906 P + L+TGYR VPL++ E L ASL + + I + G LS G RE Sbjct: 1178 FPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKENG-----DLSPFSGTSLRERG 1232 Query: 907 S 907 S Sbjct: 1233 S 1233 >gi|117320537 phospholipase C, gamma 2 [Homo sapiens] Length = 1265 Score = 213 bits (541), Expect = 1e-54 Identities = 145/446 (32%), Positives = 225/446 (50%), Gaps = 56/446 (12%) Query: 180 DSEKAKIDIKSIKEVRTGKNT-DIFRSNGISDQISEDCAFSVIYGENY--ESLDLVANSA 236 D + +DI IKE+R GKN+ D R+ + + EDC F+++YG + +L L A+S Sbjct: 59 DKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQK--EDCCFTILYGTQFVLSTLSLAADSK 116 Query: 237 DVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCI 296 + A W++GL+ L + + +S + SW+ + +D I+L + Sbjct: 117 EDAVNWLSGLKILHQ------EAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170 Query: 297 RNLNPGLKTSK-IELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNK 355 +N + ++K ++ KF E+ KD+ E FH +++ + F K Sbjct: 171 PLINFKVSSAKFLKDKFVEIGAHKDELS--------FEQFH-------LFYKKLMFEQQK 215 Query: 356 EFLDT--KDLMMFL---------------EAEQGVAHINEEISLEIIHKY--------EP 390 LD KD +F+ + ++ + H +E + ++K + Sbjct: 216 SILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDD 275 Query: 391 SKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKV-CQDMKQPLSHYFINSSHNTYLIEDQ 449 + + +L +D F YL S + I+D ++ V QDM PLSHY+I+SSHNTYL DQ Sbjct: 276 TMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQ 335 Query: 450 FRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFF 509 R S YIR L+MGCR +ELD WDGPD +PVIY G T T++I F V+ I +AF Sbjct: 336 LRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFV 395 Query: 510 ASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYLPSPDVLKGKILIKA 569 S +P+IL +E HCS++QQ+ M + K++ GD L T LPSP L+ KI+IK Sbjct: 396 TSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKH 455 Query: 570 KKLSSNCSGVEGDVTDEDEGAEMSQR 595 KKL + DV ED+ E Q+ Sbjct: 456 KKLGPR---GDVDVNMEDKKDEHKQQ 478 Score = 144 bits (362), Expect = 6e-34 Identities = 96/275 (34%), Positives = 142/275 (51%), Gaps = 22/275 (8%) Query: 610 KRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNK 669 K + ELS+LV CK + + + + + E+ SF E A + P D + YN+ Sbjct: 922 KNQSIAIELSDLVVYCKPTS--KTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQ 979 Query: 670 RFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLR 729 + L RV+P R+DSSN +P W CG Q+VA+NFQT M +N F NG GYVL+ Sbjct: 980 KGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQ 1039 Query: 730 PAIMREEVSFFSANTKDSVPGVSPQ----LLHIKIISGQNFPKPKGSGAKGDVVDPYVYV 785 P MR E D +P S + L +K++ ++ PK S + P+V V Sbjct: 1040 PESMRTE-------KYDPMPPESQRKILMTLTVKVLGARHLPKLGRS-----IACPFVEV 1087 Query: 786 EIHGIPADCAEQRTKTVHQNGDAPIF---DESFEFQINLPELAMVRFVVLDDDYIGD-EF 841 EI G D + +T V+ NG +PI+ E F+I P LA +RFVV ++D D F Sbjct: 1088 EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNF 1147 Query: 842 IGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876 + T P + +++G+R VPL++ E + ASL V Sbjct: 1148 LAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 >gi|11386139 phospholipase C beta 3 [Homo sapiens] Length = 1234 Score = 181 bits (459), Expect = 3e-45 Identities = 135/418 (32%), Positives = 214/418 (51%), Gaps = 44/418 (10%) Query: 186 IDIKSIKEVRTGKNTDIFRSNGISDQIS--------EDCAFSVIYGE---NYESLDLVAN 234 +DI SI++ RTG+ + + I + + E+ +V+ G N L+ +A Sbjct: 64 LDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAV 123 Query: 235 SADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI--DVDNLGHITLCNA 292 D A +W L L M +Q+ R +++ + ++++ V+ G I + N Sbjct: 124 QDDTAKVWSEEL--------FKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNI 175 Query: 293 VQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFS 352 ++ ++T+ +E + ++S+ E + E F ++LC RP+I +L++ Sbjct: 176 LKMFSADKKRVETA-LESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIG 234 Query: 353 SN-KEFLDTKDLMMFLEAEQGVAHINEEI--------SLEIIHKYEPSKEGQEKGWLSID 403 + K +L + LM F+ +Q +NE + + +I KYEP+++ E+ +S++ Sbjct: 235 AKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSME 294 Query: 404 GFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRAL 463 GF+ YL + I E + DM QPLS YFINSSHNTYL Q G S + Y +AL Sbjct: 295 GFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQAL 354 Query: 464 KMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLEN 521 GCR VELDVW G P+ EP I G TMT+++ R V++ I + AF S YP+IL EN Sbjct: 355 LWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFEN 414 Query: 522 HC-SIKQQKVMVQHMKKLLGDKL-------YTTSPNVEESYLPSPDVLKGKILIKAKK 571 H S KQQ M ++ + + GD L Y +P V LPSP L G+IL+K KK Sbjct: 415 HVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVP---LPSPQDLMGRILVKNKK 469 Score = 171 bits (432), Expect = 5e-42 Identities = 101/299 (33%), Positives = 159/299 (53%), Gaps = 14/299 (4%) Query: 582 DVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQK 641 D DE+E E ++ + +E+S LV+ + V+FK F+ + + K Sbjct: 554 DREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNK 613 Query: 642 YWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVA 701 +E+ SF E A + ++P +FV YNK+ L+R++P R+DSSN PQ FW GCQ+VA Sbjct: 614 CFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVA 673 Query: 702 MNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKII 761 +NFQT + M LN G F NG GY+L+P MR F T+ V G+ L +K+I Sbjct: 674 LNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVI 733 Query: 762 SGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTKTVHQNGDAPIFDES-FEF-Q 818 SGQ K V YV V++ G+P D + RT+T N P++DE F+F + Sbjct: 734 SGQFLSDRK--------VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 785 Query: 819 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVH 877 + LP LA +R ++ G +F+G +P +++GY +V L++ + L +L ++ Sbjct: 786 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIY 841 >gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] Length = 2302 Score = 170 bits (431), Expect = 6e-42 Identities = 86/211 (40%), Positives = 134/211 (63%), Gaps = 5/211 (2%) Query: 375 HINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIF-DPEHKKVCQDMKQPLS 433 H + L II K+EPS +G +S +GF +LM + + + E ++ ++++ PLS Sbjct: 1340 HCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLS 1399 Query: 434 HYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQ 493 +Y+I SSHNTYL Q +G S + Y + L GCRSVELD WDG D P+IY GHT+T++ Sbjct: 1400 YYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTK 1459 Query: 494 IVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYT----TSPN 549 I F+ V++ I++ AF S+ P+I+ +ENHCS+ QQ+ M + K + G+KL T + Sbjct: 1460 IPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDF 1519 Query: 550 VEESYLPSPDVLKGKILIKAKKLSSNCSGVE 580 ++ LPSPD L+ K+L+K KKL ++ + V+ Sbjct: 1520 SDDPMLPSPDQLRKKVLLKNKKLKAHQTPVD 1550 Score = 141 bits (355), Expect = 4e-33 Identities = 81/241 (33%), Positives = 128/241 (53%), Gaps = 13/241 (5%) Query: 641 KYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIV 700 K + + S NE A + + L R +P+ RIDSSN NP FW G Q+V Sbjct: 1753 KCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLV 1812 Query: 701 AMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREE----VSFFSANTKDSVPGVSPQLL 756 A+N+QT L + LN F NG CGYVL+P ++ ++ FS +D + + P + Sbjct: 1813 ALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERD-LDSMDPAVY 1871 Query: 757 HIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFE 816 + I+SGQN G+ P + V++ G+P D RTK +H+N P+++E F Sbjct: 1872 SLTIVSGQNVCPSNSMGS------PCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFL 1925 Query: 817 FQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876 F ++ +L +RF V++++ Q IP + L+ GYRH+ L++L EVL +SLF+ Sbjct: 1926 FHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLFI 1983 Query: 877 H 877 + Sbjct: 1984 N 1984 >gi|223633890 hypothetical protein LOC729956 [Homo sapiens] Length = 538 Score = 46.6 bits (109), Expect = 1e-04 Identities = 34/99 (34%), Positives = 44/99 (44%), Gaps = 1/99 (1%) Query: 8 GAAGGALPTSPGPALGAKGALKAG-VGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGD 66 G AGGA GP G G L+ G G GG GG G Y GV + ++GV Sbjct: 145 GGAGGAGGAGGGPGPGQAGWLEGGRTGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAK 204 Query: 67 EARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRS 105 A + +R PR P A+V L ++ PG P R+ Sbjct: 205 VAFSKASRAPRAHRDINVPRALVDILRHQAGPGTRPDRA 243 >gi|23943920 cytosolic phospholipase A2, group IVA [Homo sapiens] Length = 749 Score = 43.9 bits (102), Expect = 9e-04 Identities = 27/87 (31%), Positives = 48/87 (55%), Gaps = 8/87 (9%) Query: 773 GAKGDVVD---PYVYVEIHGIPADCAEQRTKTVHQNGDA-PIFDESFEFQINLPELAMVR 828 GA GD++D PYV + I P + R +T H N D P+++E+FEF ++ + ++ Sbjct: 33 GAFGDMLDTPDPYVELFISTTP----DSRKRTRHFNNDINPVWNETFEFILDPNQENVLE 88 Query: 829 FVVLDDDYIGDEFIGQYTIPFECLQTG 855 ++D +Y+ DE +G T ++ G Sbjct: 89 ITLMDANYVMDETLGTATFTVSSMKVG 115 >gi|61742814 coiled-coil and C2 domain containing 1B [Homo sapiens] Length = 858 Score = 41.6 bits (96), Expect = 0.004 Identities = 22/65 (33%), Positives = 35/65 (53%), Gaps = 2/65 (3%) Query: 756 LHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESF 815 +H+ I+ G N P P G D +D +V E H +D A++ V +N ++P FD+ F Sbjct: 701 MHLIIVRGMNLPAPPG--VTPDDLDAFVRFEFHYPNSDQAQKSKTAVVKNTNSPEFDQLF 758 Query: 816 EFQIN 820 + IN Sbjct: 759 KLNIN 763 >gi|55956899 keratin 9 [Homo sapiens] Length = 623 Score = 41.2 bits (95), Expect = 0.006 Identities = 27/72 (37%), Positives = 32/72 (44%), Gaps = 1/72 (1%) Query: 7 GGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGD 66 GG +GG G G+ G+ G G GGG GG G G SGG S G S G G+ Sbjct: 499 GGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGG-SGGGHSGGSGGN 557 Query: 67 EARASPTRGPRG 78 S + G G Sbjct: 558 YGGGSGSGGGSG 569 Score = 36.6 bits (83), Expect = 0.14 Identities = 24/61 (39%), Positives = 28/61 (45%), Gaps = 1/61 (1%) Query: 5 GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVS 64 GRGG+ G S G + G+ G +G G GGG G R G G Y G S G G Sbjct: 477 GRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSG-GSYGGGSGSGGGSGGGYG 535 Query: 65 G 65 G Sbjct: 536 G 536 Score = 36.2 bits (82), Expect = 0.18 Identities = 23/74 (31%), Positives = 26/74 (35%), Gaps = 1/74 (1%) Query: 5 GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVS 64 G GG+ GG + G G G G GG GGG G Y G S G G Sbjct: 515 GSGGSYGGGSGSGGGSG-GGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYG 573 Query: 65 GDEARASPTRGPRG 78 G + G G Sbjct: 574 GGSGSRGGSGGSHG 587 Score = 35.4 bits (80), Expect = 0.31 Identities = 20/53 (37%), Positives = 23/53 (43%) Query: 5 GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNG 57 G GG +GG G G+ G+ G G GG GG G G SGG G Sbjct: 563 GSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGG 615 Score = 34.7 bits (78), Expect = 0.52 Identities = 20/53 (37%), Positives = 23/53 (43%) Query: 5 GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNG 57 G GG GG + G G +G G GGG GG G G + GG S G Sbjct: 501 GSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGG 553 Score = 32.0 bits (71), Expect = 3.4 Identities = 22/56 (39%), Positives = 25/56 (44%), Gaps = 8/56 (14%) Query: 5 GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYD--SGGVSNGD 58 G GGA+GG +S G G G G GGG GG G G + GG GD Sbjct: 96 GFGGASGGGYSSSGGFGGGFGG------GSGGGFGGGYGSGFGGFGGFGGGAGGGD 145 Score = 32.0 bits (71), Expect = 3.4 Identities = 23/67 (34%), Positives = 26/67 (38%), Gaps = 6/67 (8%) Query: 5 GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVS 64 G G +GG G G+ G G G GG GG G G GG S G Sbjct: 549 GHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSG---FGGESGGSYG---G 602 Query: 65 GDEARAS 71 G+EA S Sbjct: 603 GEEASGS 609 Score = 31.6 bits (70), Expect = 4.4 Identities = 26/65 (40%), Positives = 28/65 (43%), Gaps = 7/65 (10%) Query: 4 CGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRAR---YDSGGVSNGDCS 60 CGRGG GG+ S G G+ G A GG GGG G G A Y S G G Sbjct: 61 CGRGG--GGSFGYSYGG--GSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFG 116 Query: 61 LGVSG 65 G G Sbjct: 117 GGSGG 121 Score = 31.2 bits (69), Expect = 5.8 Identities = 22/55 (40%), Positives = 26/55 (47%), Gaps = 4/55 (7%) Query: 24 AKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCSLGVSGDEARASPTRGPRG 78 + GA K G+G GG GG G G +R SGG G G G S +RG G Sbjct: 467 SSGAGKIGLGGRGGSGGSYGRG-SRGGSGGSYGGG---GSGGGYGGGSGSRGGSG 517 Score = 31.2 bits (69), Expect = 5.8 Identities = 19/53 (35%), Positives = 22/53 (41%), Gaps = 5/53 (9%) Query: 5 GRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNG 57 G GG+ GG G G++G G G G GG G G GG S G Sbjct: 498 GGGGSGGGY-----GGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGG 545 >gi|21361472 neural precursor cell expressed, developmentally down-regulated 4-like isoform 3 [Homo sapiens] Length = 955 Score = 40.8 bits (94), Expect = 0.007 Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%) Query: 754 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 811 ++L +K++SG + K GA DPYV + ++ + A +TKT+ + + P + Sbjct: 20 RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 74 Query: 812 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 854 +E F F++N P + F V D++ + D+F+GQ +P L T Sbjct: 75 NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 117 >gi|222352090 neural precursor cell expressed, developmentally down-regulated 4-like isoform 5 [Homo sapiens] Length = 947 Score = 40.8 bits (94), Expect = 0.007 Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%) Query: 754 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 811 ++L +K++SG + K GA DPYV + ++ + A +TKT+ + + P + Sbjct: 12 RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 66 Query: 812 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 854 +E F F++N P + F V D++ + D+F+GQ +P L T Sbjct: 67 NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 109 >gi|222352088 neural precursor cell expressed, developmentally down-regulated 4-like isoform 4 [Homo sapiens] Length = 967 Score = 40.8 bits (94), Expect = 0.007 Identities = 31/104 (29%), Positives = 56/104 (53%), Gaps = 9/104 (8%) Query: 754 QLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPA--DCAEQRTKTVHQNGDAPIF 811 ++L +K++SG + K GA DPYV + ++ + A +TKT+ + + P + Sbjct: 12 RILRVKVVSGIDLAKKDIFGAS----DPYVKLSLYVADENRELALVQTKTIKKTLN-PKW 66 Query: 812 DESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTIPFECLQT 854 +E F F++N P + F V D++ + D+F+GQ +P L T Sbjct: 67 NEEFYFRVN-PSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPT 109 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.134 0.396 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 44,024,954 Number of Sequences: 37866 Number of extensions: 2092017 Number of successful extensions: 11134 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 81 Number of HSP's successfully gapped in prelim test: 195 Number of HSP's that attempted gapping in prelim test: 9089 Number of HSP's gapped (non-prelim): 1364 length of query: 1127 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1014 effective length of database: 13,968,660 effective search space: 14164221240 effective search space used: 14164221240 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.