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Search of human proteins with 22027612
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]
(501 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027612 TNF receptor-associated factor 2 [Homo sapiens] 1036 0.0
gi|22027627 TNF receptor-associated factor 5 [Homo sapiens] 293 2e-79
gi|77404348 TNF receptor-associated factor 5 [Homo sapiens] 293 2e-79
gi|11321603 TNF receptor-associated factor 5 [Homo sapiens] 293 2e-79
gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo sap... 291 1e-78
gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo sap... 291 1e-78
gi|5032193 TNF receptor-associated factor 1 [Homo sapiens] 275 9e-74
gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo sap... 275 9e-74
gi|22027622 TNF receptor-associated factor 4 [Homo sapiens] 213 4e-55
gi|22027630 TNF receptor-associated factor 6 [Homo sapiens] 198 8e-51
gi|4759254 TNF receptor-associated factor 6 [Homo sapiens] 198 8e-51
gi|87241872 ring finger protein 151 [Homo sapiens] 54 3e-07
gi|71143146 zinc finger protein 230 [Homo sapiens] 48 2e-05
gi|194097339 zinc finger protein 222 isoform 1 [Homo sapiens] 48 2e-05
gi|194018453 zinc finger protein 222 isoform 2 [Homo sapiens] 48 2e-05
gi|40288193 XIAP associated factor 1 isoform 2 [Homo sapiens] 45 1e-04
gi|153070264 meprin A beta [Homo sapiens] 45 2e-04
gi|30520320 ring finger protein 166 [Homo sapiens] 44 3e-04
gi|38045952 zinc finger protein 14 [Homo sapiens] 44 3e-04
gi|153070262 meprin A alpha [Homo sapiens] 44 4e-04
gi|170932473 zinc finger protein 786 [Homo sapiens] 44 4e-04
gi|8923898 zinc finger protein 313 [Homo sapiens] 43 6e-04
gi|219879806 TRAF-type zinc finger domain containing 1 [Homo sap... 42 0.001
gi|5729828 TRAF-type zinc finger domain containing 1 [Homo sapiens] 42 0.001
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 41 0.002
gi|23312364 ubiquitin-like with PHD and ring finger domains 2 [H... 41 0.003
gi|30023818 tripartite motif protein 50A [Homo sapiens] 41 0.003
gi|37595555 ring finger protein 125 [Homo sapiens] 41 0.003
gi|37655173 zinc finger protein 155 [Homo sapiens] 40 0.004
gi|37655171 zinc finger protein 155 [Homo sapiens] 40 0.004
>gi|22027612 TNF receptor-associated factor 2 [Homo sapiens]
Length = 501
Score = 1036 bits (2678), Expect = 0.0
Identities = 501/501 (100%), Positives = 501/501 (100%)
Query: 1 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLAS 60
MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLAS
Sbjct: 1 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLAS 60
Query: 61 ILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKE 120
ILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKE
Sbjct: 61 ILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKE 120
Query: 121 YESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE 180
YESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE
Sbjct: 121 YESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE 180
Query: 181 VCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWL 240
VCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWL
Sbjct: 181 VCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWL 240
Query: 241 REHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTA 300
REHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTA
Sbjct: 241 REHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTA 300
Query: 301 EACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISD 360
EACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISD
Sbjct: 301 EACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISD 360
Query: 361 FARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDA 420
FARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDA
Sbjct: 361 FARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDA 420
Query: 421 LLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEA 480
LLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEA
Sbjct: 421 LLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEA 480
Query: 481 KNSYVRDDAIFIKAIVDLTGL 501
KNSYVRDDAIFIKAIVDLTGL
Sbjct: 481 KNSYVRDDAIFIKAIVDLTGL 501
>gi|22027627 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 293 bits (750), Expect = 2e-79
Identities = 172/528 (32%), Positives = 276/528 (52%), Gaps = 64/528 (12%)
Query: 27 KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASI--LSSGPQNCAACVHEGIYEEGISI 84
+LE +Y C+ C +VL P Q CGHR+C C+ S+ L++ P I +
Sbjct: 38 RLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVP----------ICPVDKEV 87
Query: 85 LESSSAFPDNAARREVESLPAVCPS-DGCTWKGTLKEYESCHEGRCPLMLTECP--ACKG 141
++S F DN +REV +L C + GC K L Y+ H +C +C C+
Sbjct: 88 IKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQD-HLQQCLFQPVQCSNEKCRE 146
Query: 142 LVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE-VCPKFPLTCDGCGKKKIPRE 200
V + + HL C R C +C+ +++ H E +CP++P+ C K I +
Sbjct: 147 PVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKT 206
Query: 201 KFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGD 260
+ +H+ C + C F GC T + Q+HE LREH+ ++L ++ + + D
Sbjct: 207 EVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISD 266
Query: 261 QSHA----GSELLQRCESLEKKTATFENIVCVLNRE----------VERVAMTAEACSRQ 306
+ S++ Q E+++K F+ + + + +A ++
Sbjct: 267 LHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQV 326
Query: 307 HRLDQ---------------DKIEALSSKVQQLERS-----------------IGLKDLA 334
H+L Q + ++ + K+ LE + I +
Sbjct: 327 HQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQ 386
Query: 335 MADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRI 394
++ E++ +E + Y+G IWK++D+ K++EAV G +IFS +FYTSR GY++C R
Sbjct: 387 LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARA 446
Query: 395 YLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSS 454
YLNGDG+GRG+HLSL+FVVM+G D+LL+WPF Q+VTLMLLDQ+ ++++++ F+PD SS
Sbjct: 447 YLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSS 506
Query: 455 SFQRPVNDMNIASGCPLFCPVSKME-AKNSYVRDDAIFIKAIVDLTGL 501
SF+RP +MNIASGCP F S +E AKN+Y++DD +F+K VDLT L
Sbjct: 507 SFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDL 554
>gi|77404348 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 293 bits (750), Expect = 2e-79
Identities = 172/528 (32%), Positives = 276/528 (52%), Gaps = 64/528 (12%)
Query: 27 KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASI--LSSGPQNCAACVHEGIYEEGISI 84
+LE +Y C+ C +VL P Q CGHR+C C+ S+ L++ P I +
Sbjct: 38 RLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVP----------ICPVDKEV 87
Query: 85 LESSSAFPDNAARREVESLPAVCPS-DGCTWKGTLKEYESCHEGRCPLMLTECP--ACKG 141
++S F DN +REV +L C + GC K L Y+ H +C +C C+
Sbjct: 88 IKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQD-HLQQCLFQPVQCSNEKCRE 146
Query: 142 LVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE-VCPKFPLTCDGCGKKKIPRE 200
V + + HL C R C +C+ +++ H E +CP++P+ C K I +
Sbjct: 147 PVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKT 206
Query: 201 KFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGD 260
+ +H+ C + C F GC T + Q+HE LREH+ ++L ++ + + D
Sbjct: 207 EVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISD 266
Query: 261 QSHA----GSELLQRCESLEKKTATFENIVCVLNRE----------VERVAMTAEACSRQ 306
+ S++ Q E+++K F+ + + + +A ++
Sbjct: 267 LHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQV 326
Query: 307 HRLDQ---------------DKIEALSSKVQQLERS-----------------IGLKDLA 334
H+L Q + ++ + K+ LE + I +
Sbjct: 327 HQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQ 386
Query: 335 MADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRI 394
++ E++ +E + Y+G IWK++D+ K++EAV G +IFS +FYTSR GY++C R
Sbjct: 387 LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARA 446
Query: 395 YLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSS 454
YLNGDG+GRG+HLSL+FVVM+G D+LL+WPF Q+VTLMLLDQ+ ++++++ F+PD SS
Sbjct: 447 YLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSS 506
Query: 455 SFQRPVNDMNIASGCPLFCPVSKME-AKNSYVRDDAIFIKAIVDLTGL 501
SF+RP +MNIASGCP F S +E AKN+Y++DD +F+K VDLT L
Sbjct: 507 SFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDL 554
>gi|11321603 TNF receptor-associated factor 5 [Homo sapiens]
Length = 557
Score = 293 bits (750), Expect = 2e-79
Identities = 172/528 (32%), Positives = 276/528 (52%), Gaps = 64/528 (12%)
Query: 27 KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASI--LSSGPQNCAACVHEGIYEEGISI 84
+LE +Y C+ C +VL P Q CGHR+C C+ S+ L++ P I +
Sbjct: 38 RLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVP----------ICPVDKEV 87
Query: 85 LESSSAFPDNAARREVESLPAVCPS-DGCTWKGTLKEYESCHEGRCPLMLTECP--ACKG 141
++S F DN +REV +L C + GC K L Y+ H +C +C C+
Sbjct: 88 IKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQD-HLQQCLFQPVQCSNEKCRE 146
Query: 142 LVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHE-VCPKFPLTCDGCGKKKIPRE 200
V + + HL C R C +C+ +++ H E +CP++P+ C K I +
Sbjct: 147 PVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKT 206
Query: 201 KFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGD 260
+ +H+ C + C F GC T + Q+HE LREH+ ++L ++ + + D
Sbjct: 207 EVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISD 266
Query: 261 QSHA----GSELLQRCESLEKKTATFENIVCVLNRE----------VERVAMTAEACSRQ 306
+ S++ Q E+++K F+ + + + +A ++
Sbjct: 267 LHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQV 326
Query: 307 HRLDQ---------------DKIEALSSKVQQLERS-----------------IGLKDLA 334
H+L Q + ++ + K+ LE + I +
Sbjct: 327 HQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQ 386
Query: 335 MADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRI 394
++ E++ +E + Y+G IWK++D+ K++EAV G +IFS +FYTSR GY++C R
Sbjct: 387 LSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARA 446
Query: 395 YLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSS 454
YLNGDG+GRG+HLSL+FVVM+G D+LL+WPF Q+VTLMLLDQ+ ++++++ F+PD SS
Sbjct: 447 YLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSS 506
Query: 455 SFQRPVNDMNIASGCPLFCPVSKME-AKNSYVRDDAIFIKAIVDLTGL 501
SF+RP +MNIASGCP F S +E AKN+Y++DD +F+K VDLT L
Sbjct: 507 SFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDL 554
>gi|22027616 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 291 bits (744), Expect = 1e-78
Identities = 185/549 (33%), Positives = 286/549 (52%), Gaps = 82/549 (14%)
Query: 16 QPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHE 75
Q G+ + + T +E KY C C VL P Q +CGHR+C C+A++LSS C AC E
Sbjct: 36 QGGYKEKFVKT-VEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTAC-QE 93
Query: 76 GIYEEGISILESSSAFPDNAARREVESLPAVCPSD--GCTWKGTLKEY-----ESCHEGR 128
I ++ + F DN +RE+ +L C ++ GC + L CH
Sbjct: 94 SIVKDKV--------FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEE 145
Query: 129 CPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEV-CPKFPL 187
P + P CK V + H+E C R +C HC++ ++ H + CP +
Sbjct: 146 LPCVR---PDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVV 202
Query: 188 TCDG-CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAM 246
+C C + + R + H+ C C F GC+ ++ + HE +H+ +
Sbjct: 203 SCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNL 262
Query: 247 LL--SSVLEAK-PLLGDQSHAGSELLQRCESLEKKTATFE------------------NI 285
L S+ LE K LL ++S ++ +Q SL + +FE ++
Sbjct: 263 LKEWSNSLEKKVSLLQNESVEKNKSIQ---SLHNQICSFEIEIERQKEMLRNNESKILHL 319
Query: 286 VCVLNREVERV------------------AMTAEACSRQHRLDQDKIEALSSKVQQLERS 327
V++ + E++ +M + S Q+R+ + +E++ Q+ R+
Sbjct: 320 QRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTE--LESVDKSAGQVARN 377
Query: 328 IGL--------------KDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRI 373
GL D+ +AD++ + +E ++Y+GV IWKI D+ R++QEAV G+
Sbjct: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
Query: 374 PAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLM 433
+++S FYT +GYKMC R+YLNGDG G+GTHLSLFFV+M+G DALL WPF QKVTLM
Sbjct: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
Query: 434 LLDQ-NNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFI 492
L+DQ ++R H+ DAF+PD SSSF++P +MNIASGCP+F + +E +Y++DD IFI
Sbjct: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFI 556
Query: 493 KAIVDLTGL 501
K IVD + L
Sbjct: 557 KVIVDTSDL 565
>gi|22027618 TNF receptor-associated factor 3 isoform 1 [Homo
sapiens]
Length = 568
Score = 291 bits (744), Expect = 1e-78
Identities = 185/549 (33%), Positives = 286/549 (52%), Gaps = 82/549 (14%)
Query: 16 QPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHE 75
Q G+ + + T +E KY C C VL P Q +CGHR+C C+A++LSS C AC E
Sbjct: 36 QGGYKEKFVKT-VEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTAC-QE 93
Query: 76 GIYEEGISILESSSAFPDNAARREVESLPAVCPSD--GCTWKGTLKEY-----ESCHEGR 128
I ++ + F DN +RE+ +L C ++ GC + L CH
Sbjct: 94 SIVKDKV--------FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEE 145
Query: 129 CPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEV-CPKFPL 187
P + P CK V + H+E C R +C HC++ ++ H + CP +
Sbjct: 146 LPCVR---PDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVV 202
Query: 188 TCDG-CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAM 246
+C C + + R + H+ C C F GC+ ++ + HE +H+ +
Sbjct: 203 SCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNL 262
Query: 247 LL--SSVLEAK-PLLGDQSHAGSELLQRCESLEKKTATFE------------------NI 285
L S+ LE K LL ++S ++ +Q SL + +FE ++
Sbjct: 263 LKEWSNSLEKKVSLLQNESVEKNKSIQ---SLHNQICSFEIEIERQKEMLRNNESKILHL 319
Query: 286 VCVLNREVERV------------------AMTAEACSRQHRLDQDKIEALSSKVQQLERS 327
V++ + E++ +M + S Q+R+ + +E++ Q+ R+
Sbjct: 320 QRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTE--LESVDKSAGQVARN 377
Query: 328 IGL--------------KDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRI 373
GL D+ +AD++ + +E ++Y+GV IWKI D+ R++QEAV G+
Sbjct: 378 TGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKT 437
Query: 374 PAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLM 433
+++S FYT +GYKMC R+YLNGDG G+GTHLSLFFV+M+G DALL WPF QKVTLM
Sbjct: 438 LSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLM 497
Query: 434 LLDQ-NNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFI 492
L+DQ ++R H+ DAF+PD SSSF++P +MNIASGCP+F + +E +Y++DD IFI
Sbjct: 498 LMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFI 556
Query: 493 KAIVDLTGL 501
K IVD + L
Sbjct: 557 KVIVDTSDL 565
>gi|5032193 TNF receptor-associated factor 1 [Homo sapiens]
Length = 416
Score = 275 bits (702), Expect = 9e-74
Identities = 158/388 (40%), Positives = 221/388 (56%), Gaps = 57/388 (14%)
Query: 159 RSLSCRHCRA--PCCGADVKAHHEVCPKF---PLTCDGCGKKKIPREKFQDHVKTCGKCR 213
R+L C C + P G D ++CPK L G + +EK V G
Sbjct: 34 RALCCAGCLSENPRNGED-----QICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAG--- 85
Query: 214 VPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCE 273
+ C F +GC + QEHEV HL +LL + + K LG +G L++
Sbjct: 86 IGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNL 145
Query: 274 S-------------------------------------------LEKKTATFENIVCVLN 290
S LE K FENIV VLN
Sbjct: 146 SDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLN 205
Query: 291 REVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTY 350
+EVE + Q +LD+++I +L +V +L++++ KD A+ LEQ + ME +++
Sbjct: 206 KEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQSLRLMEEASF 265
Query: 351 DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLF 410
DG F+WKI++ R+ E+ GR ++FSPAFYT++YGYK+CLR+YLNGDGTG+ THLSLF
Sbjct: 266 DGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLF 325
Query: 411 FVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCP 470
V+M+G DALL WPF KVT MLLDQNNREH IDAFRPD++S+SFQRP ++ N+ASGCP
Sbjct: 326 IVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCP 385
Query: 471 LFCPVSKMEA-KNSYVRDDAIFIKAIVD 497
LF P+SK+++ K++YV+DD +F+K IV+
Sbjct: 386 LFFPLSKLQSPKHAYVKDDTMFLKCIVE 413
>gi|22027620 TNF receptor-associated factor 3 isoform 2 [Homo
sapiens]
Length = 543
Score = 275 bits (702), Expect = 9e-74
Identities = 179/526 (34%), Positives = 277/526 (52%), Gaps = 61/526 (11%)
Query: 16 QPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHE 75
Q G+ + + T +E KY C C VL P Q +CGHR+C C+A++LSS C AC E
Sbjct: 36 QGGYKEKFVKT-VEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTAC-QE 93
Query: 76 GIYEEGISILESSSAFPDNAARREVESLPAVCPSD--GCTWKGTLKEY-----ESCHEGR 128
I ++ + F DN +RE+ +L C ++ GC + L CH
Sbjct: 94 SIVKDKV--------FKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEE 145
Query: 129 CPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEV-CPKFPL 187
P + P CK V + H+E C R +C HC++ ++ H + CP +
Sbjct: 146 LPCVR---PDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVV 202
Query: 188 TCDG-CGKKKIPR-----EKFQDHVKTCGKCRVPCRFHAIGCLE---------TVEGEKQ 232
+C C + + R ++ + H + V LE +VE K
Sbjct: 203 SCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKS 262
Query: 233 Q----------EHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRC----ESLEKK 278
E E++ +E L S +L + ++ Q+ EL + ++ E+
Sbjct: 263 IQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEA 322
Query: 279 TATFENIVCVLNR--EVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMA 336
+ ++ + NR E+E V +A +R L L S++ + ++ + + D+ +A
Sbjct: 323 DSMKSSVESLQNRVTELESVDKSAGQVARNTGL-------LESQLSRHDQMLSVHDIRLA 375
Query: 337 DLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYL 396
D++ + +E ++Y+GV IWKI D+ R++QEAV G+ +++S FYT +GYKMC R+YL
Sbjct: 376 DMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYL 435
Query: 397 NGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQ-NNREHVIDAFRPDVTSSS 455
NGDG G+GTHLSLFFV+M+G DALL WPF QKVTLML+DQ ++R H+ DAF+PD SSS
Sbjct: 436 NGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSS 495
Query: 456 FQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL 501
F++P +MNIASGCP+F + +E +Y++DD IFIK IVD + L
Sbjct: 496 FKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFIKVIVDTSDL 540
>gi|22027622 TNF receptor-associated factor 4 [Homo sapiens]
Length = 470
Score = 213 bits (541), Expect = 4e-55
Identities = 148/498 (29%), Positives = 227/498 (45%), Gaps = 51/498 (10%)
Query: 17 PGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQ-CGHRYCSFCLASILSSGPQNCAACVHE 75
PGF L K + + LC C +R P Q CGHR+C CL LS G C
Sbjct: 2 PGFDYKFL-EKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCP----- 55
Query: 76 GIYEEGISILESSSAFPDNAARREVESLPAVC--PSDGCTWKGTLKEYESCHEGRCPLML 133
E L+ + +PD +V LP C +GC W G L+ + H C +
Sbjct: 56 ----EDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQG-HLNTCSFNV 110
Query: 134 TECP-ACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDG- 191
CP C + + HL+H+CP+R L C C G ++H +CP+ + C+
Sbjct: 111 IPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENK 170
Query: 192 CGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSV 251
CG + + R Q C K PC + C + + Q H+ Q R +A
Sbjct: 171 CGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDTIQSHQYQCPRLPVAC----- 221
Query: 252 LEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQ 311
+Q G+ + K + ++C + A +R
Sbjct: 222 -------PNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVE--- 271
Query: 312 DKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAG 371
E++ + + + + + +L +++ E+ + DGV IWKI + R+ QEA A
Sbjct: 272 ---ESVKPHLAMMCALVSRQRQELQELRRELEELSVGS-DGVLIWKIGSYGRRLQEAKAK 327
Query: 372 RIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVT 431
FSPAFYT +YGYK+ + +LNG+G+G GTHLSL+ V+ G D LL WPF ++VT
Sbjct: 328 PNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVT 387
Query: 432 LMLLDQNN-----REHVIDAFRPDVTSSSFQRP------VNDMNIASGCPLFCPVSKMEA 480
LLDQ++ +HV + F PD +FQ+P +++ ++ G P F +
Sbjct: 388 FSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRK 447
Query: 481 KNSYVRDDAIFIKAIVDL 498
+N YVRDDA+FI+A V+L
Sbjct: 448 RN-YVRDDAVFIRAAVEL 464
>gi|22027630 TNF receptor-associated factor 6 [Homo sapiens]
Length = 522
Score = 198 bits (504), Expect = 8e-51
Identities = 138/478 (28%), Positives = 216/478 (45%), Gaps = 51/478 (10%)
Query: 28 LEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILES 87
LE+KY C C LR Q CGHR+C C+ + C IL
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPV---------DNEILLE 114
Query: 88 SSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGE 147
+ FPDN A+RE+ SL CP++GC K L+ E H+ C L +CP C+ +
Sbjct: 115 NQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLED-HQAHCEFALMDCPQCQRPFQKFH 173
Query: 148 KERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVK 207
H+ +CP R +SC +C A D + H + CP + C+ C I RE+ +H
Sbjct: 174 INIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILI-REQMPNHYD 232
Query: 208 T-CGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGS 266
C +PC F GC E ++ H + + H+ ML +V + ++ D +
Sbjct: 233 LDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAV-HSLSVIPDSGYIS- 290
Query: 267 ELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLER 326
+ F+ + L + R Q R K+E S V +L+R
Sbjct: 291 -----------EVRNFQETIHQLEGRLVRQ-------DHQIRELTAKMETQSMYVSELKR 332
Query: 327 SIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRY 386
+I LE KV E+EA +G++IWKI +F + + I SP FYT +
Sbjct: 333 TI-------RTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKP 385
Query: 387 GYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQN------N 439
GYK+C+R++L R ++SLF M+G D+ L WPF + L +LDQ+ N
Sbjct: 386 GYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQN 445
Query: 440 REHVIDAFRPDVTSSSFQRPVNDMNIAS-GCPLFCPVSKMEAKNSYVRDDAIFIKAIV 496
E ++DA +P++ +FQRP N G F + + + ++++DD + ++ V
Sbjct: 446 HEEIMDA-KPELL--AFQRPTIPRNPKGFGYVTFMHLEALR-QRTFIKDDTLLVRCEV 499
>gi|4759254 TNF receptor-associated factor 6 [Homo sapiens]
Length = 522
Score = 198 bits (504), Expect = 8e-51
Identities = 138/478 (28%), Positives = 216/478 (45%), Gaps = 51/478 (10%)
Query: 28 LEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILES 87
LE+KY C C LR Q CGHR+C C+ + C IL
Sbjct: 64 LESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPV---------DNEILLE 114
Query: 88 SSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGE 147
+ FPDN A+RE+ SL CP++GC K L+ E H+ C L +CP C+ +
Sbjct: 115 NQLFPDNFAKREILSLMVKCPNEGCLHKMELRHLED-HQAHCEFALMDCPQCQRPFQKFH 173
Query: 148 KERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVK 207
H+ +CP R +SC +C A D + H + CP + C+ C I RE+ +H
Sbjct: 174 INIHILKDCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILI-REQMPNHYD 232
Query: 208 T-CGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGS 266
C +PC F GC E ++ H + + H+ ML +V + ++ D +
Sbjct: 233 LDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAV-HSLSVIPDSGYIS- 290
Query: 267 ELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLER 326
+ F+ + L + R Q R K+E S V +L+R
Sbjct: 291 -----------EVRNFQETIHQLEGRLVRQ-------DHQIRELTAKMETQSMYVSELKR 332
Query: 327 SIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRY 386
+I LE KV E+EA +G++IWKI +F + + I SP FYT +
Sbjct: 333 TI-------RTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKP 385
Query: 387 GYKMCLRIYLNGDGTGR-GTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQN------N 439
GYK+C+R++L R ++SLF M+G D+ L WPF + L +LDQ+ N
Sbjct: 386 GYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQN 445
Query: 440 REHVIDAFRPDVTSSSFQRPVNDMNIAS-GCPLFCPVSKMEAKNSYVRDDAIFIKAIV 496
E ++DA +P++ +FQRP N G F + + + ++++DD + ++ V
Sbjct: 446 HEEIMDA-KPELL--AFQRPTIPRNPKGFGYVTFMHLEALR-QRTFIKDDTLLVRCEV 499
>gi|87241872 ring finger protein 151 [Homo sapiens]
Length = 245
Score = 54.3 bits (129), Expect = 3e-07
Identities = 43/161 (26%), Positives = 64/161 (39%), Gaps = 21/161 (13%)
Query: 18 GFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGI 77
G+ L + ++ ++CS C VL+RP + C H +C C+ L+ + C C E
Sbjct: 4 GYDLNLFASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCILRWLAR-QKTCPCCRKE-- 60
Query: 78 YEEGISILESSSAFPDNAARREVESLPAVCPS--DGCTWKGTLKEYESCHEGRCPLMLTE 135
++ N R+ + L C + GC L + H+ CP LT
Sbjct: 61 -------VKRKKVVHMNKLRKTIGRLEVKCKNADAGCIVTCPL-AHRKGHQDSCPFELTA 112
Query: 136 CP--ACKGLVRLGEKERHLEHECPERSLSCRHCRAPC-CGA 173
CP C V G H +H C + S R P CGA
Sbjct: 113 CPNEGCTSQVPRGTLAEHRQH-CQQGSQQ----RCPLGCGA 148
>gi|71143146 zinc finger protein 230 [Homo sapiens]
Length = 474
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/201 (24%), Positives = 71/201 (35%), Gaps = 37/201 (18%)
Query: 29 EAKYLCSACRNVLRRPFQAQ----------------CGHRYCSFCLASILSSGPQNCAAC 72
E Y+C C FQ Q CG SFCL S L+ ++C
Sbjct: 249 EKPYICEKCGRAFIHDFQLQKHQIIHTGEKPFKCEICGK---SFCLRSSLN---RHCMVH 302
Query: 73 VHEGIYEEGISILESSSAFPDNAARREVESL-----PAVCPSDGCT--WKGTLKEYESCH 125
E +Y+ E F D+ + + + P C G + W L ++ H
Sbjct: 303 TAEKLYKSE----ECGKGFTDSLDLHKHQIIHTGQKPYNCKECGKSFRWSSYLLIHQRIH 358
Query: 126 EGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEV--CP 183
G P EC KG + H ER +C+ C A +H+ C
Sbjct: 359 SGEKPYRCEECG--KGYISKSGLNLHQRVHTGERPYNCKECGKSFSRASSILNHKKLHCR 416
Query: 184 KFPLTCDGCGKKKIPREKFQD 204
K P C+ CGK+ + R +D
Sbjct: 417 KKPFKCEDCGKRLVHRSFCKD 437
>gi|194097339 zinc finger protein 222 isoform 1 [Homo sapiens]
Length = 491
Score = 47.8 bits (112), Expect = 2e-05
Identities = 50/198 (25%), Positives = 73/198 (36%), Gaps = 31/198 (15%)
Query: 29 EAKYLCSACRNVLRRPFQAQCGHRY-----------C--SFCLASILSSGPQNCAACVHE 75
E Y C C FQ Q HR C SFCL S L+ ++C E
Sbjct: 266 EKPYNCEKCGKAFMHNFQLQKHHRIHTGEKPFKCEICGKSFCLRSSLN---RHCMVHTAE 322
Query: 76 GIYEEGISILESSSAFPDNAARREVESL-----PAVCPSDGCT--WKGTLKEYESCHEGR 128
+Y+ + F D + + + P C G + W L ++ H G
Sbjct: 323 KLYKSE----KYGRGFIDRLDLHKHQMIHMGQKPYNCKECGKSFKWSSYLLVHQRVHTGE 378
Query: 129 CPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEV--CPKFP 186
P EC KG + + H ERS +C +C A +H+ C + P
Sbjct: 379 KPYKCEECG--KGYISKSGLDFHHRTHTGERSYNCDNCGKSFRHASSILNHKKLHCQRKP 436
Query: 187 LTCDGCGKKKIPREKFQD 204
L C+ CGK+ + R +D
Sbjct: 437 LKCEDCGKRLVCRSYCKD 454
>gi|194018453 zinc finger protein 222 isoform 2 [Homo sapiens]
Length = 451
Score = 47.8 bits (112), Expect = 2e-05
Identities = 50/198 (25%), Positives = 73/198 (36%), Gaps = 31/198 (15%)
Query: 29 EAKYLCSACRNVLRRPFQAQCGHRY-----------C--SFCLASILSSGPQNCAACVHE 75
E Y C C FQ Q HR C SFCL S L+ ++C E
Sbjct: 226 EKPYNCEKCGKAFMHNFQLQKHHRIHTGEKPFKCEICGKSFCLRSSLN---RHCMVHTAE 282
Query: 76 GIYEEGISILESSSAFPDNAARREVESL-----PAVCPSDGCT--WKGTLKEYESCHEGR 128
+Y+ + F D + + + P C G + W L ++ H G
Sbjct: 283 KLYKSE----KYGRGFIDRLDLHKHQMIHMGQKPYNCKECGKSFKWSSYLLVHQRVHTGE 338
Query: 129 CPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEV--CPKFP 186
P EC KG + + H ERS +C +C A +H+ C + P
Sbjct: 339 KPYKCEECG--KGYISKSGLDFHHRTHTGERSYNCDNCGKSFRHASSILNHKKLHCQRKP 396
Query: 187 LTCDGCGKKKIPREKFQD 204
L C+ CGK+ + R +D
Sbjct: 397 LKCEDCGKRLVCRSYCKD 414
>gi|40288193 XIAP associated factor 1 isoform 2 [Homo sapiens]
Length = 282
Score = 45.4 bits (106), Expect = 1e-04
Identities = 25/76 (32%), Positives = 33/76 (43%), Gaps = 6/76 (7%)
Query: 125 HEGRCPLMLTECPACKGLVRLGEKERH--LEH----ECPERSLSCRHCRAPCCGADVKAH 178
HE C L CP C+ V E H LEH EC ER + C+ C+ + ++ H
Sbjct: 23 HEAYCLRFLVLCPECEEPVPKETMEEHCKLEHQQANECQERPVECKFCKLDMQLSKLELH 82
Query: 179 HEVCPKFPLTCDGCGK 194
C C GCG+
Sbjct: 83 ESYCGSRTELCQGCGQ 98
Score = 36.2 bits (82), Expect = 0.071
Identities = 21/81 (25%), Positives = 37/81 (45%), Gaps = 12/81 (14%)
Query: 163 CRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVK-------TCGKCRVP 215
CR+C+ A+ H C +F + C C ++ +P+E ++H K C + V
Sbjct: 8 CRNCKRHVVSANFTLHEAYCLRFLVLCPEC-EEPVPKETMEEHCKLEHQQANECQERPVE 66
Query: 216 CRFHAIGCLETVEGEKQQEHE 236
C+F C ++ K + HE
Sbjct: 67 CKF----CKLDMQLSKLELHE 83
>gi|153070264 meprin A beta [Homo sapiens]
Length = 701
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/85 (35%), Positives = 46/85 (54%), Gaps = 11/85 (12%)
Query: 355 IWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVM 414
IW I +F + + ++SP FY+S+ GY +IYLN T+ ++F ++
Sbjct: 431 IWHIRNFT----QFIGSPNGTLYSPPFYSSK-GY--AFQIYLN---LAHVTNAGIYFHLI 480
Query: 415 KGPNDALLRWPFN-QKVTLMLLDQN 438
G ND L+WP Q+ T+ LLDQN
Sbjct: 481 SGANDDQLQWPCPWQQATMTLLDQN 505
>gi|30520320 ring finger protein 166 [Homo sapiens]
Length = 237
Score = 44.3 bits (103), Expect = 3e-04
Identities = 38/143 (26%), Positives = 49/143 (34%), Gaps = 14/143 (9%)
Query: 28 LEAKYLCSACRNVLRRPFQ-AQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILE 86
LEA+Y C C V RP CGH +C CL L C C L
Sbjct: 27 LEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCLQVPSPLCPLC-----------RLP 75
Query: 87 SSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLG 146
D A E + P GC K TL + H C + + C V +
Sbjct: 76 FDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMR-VHISSCLKVQEQMANCPKFVPVV 134
Query: 147 EKERHLEHECPERS-LSCRHCRA 168
+ + P RS +C +C A
Sbjct: 135 PTSQPIPSNIPNRSTFACPYCGA 157
>gi|38045952 zinc finger protein 14 [Homo sapiens]
Length = 642
Score = 43.9 bits (102), Expect = 3e-04
Identities = 35/146 (23%), Positives = 53/146 (36%), Gaps = 6/146 (4%)
Query: 66 PQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWK--GTLKEYES 123
P C+ C + I+ ++ S +E E P C + G T+ +++E
Sbjct: 102 PHECSFCGRDFIHHSSLNRHMRSHTGQKPNEYQEYEKQPCKCKAVGKTFSYHHCFRKHER 161
Query: 124 CHEGRCPLMLTECPAC-KGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVC 182
H G P EC C K + +RH ++ C+ C H
Sbjct: 162 THTGVKPY---ECKQCGKAFIYYQPFQRHERTHAGQKPYECKQCGKTFIYYQSFQKHAHT 218
Query: 183 PKFPLTCDGCGKKKIPREKFQDHVKT 208
K P C CGK I + FQ H +T
Sbjct: 219 GKKPYECKQCGKAFICYQSFQRHKRT 244
Score = 36.6 bits (83), Expect = 0.055
Identities = 27/99 (27%), Positives = 42/99 (42%), Gaps = 6/99 (6%)
Query: 113 TWKGTLKEYESCHEGRCPLMLTECPAC-KGLVRLGEKERHLEHECPERSLSCRHC-RAPC 170
++ +L+E+E+ H G P EC C K +RH E+ C+ C +A
Sbjct: 401 SFSSSLREHETTHTGEKPY---ECKQCGKTFSFSSSLQRHERTHNAEKPYECKQCGKAFR 457
Query: 171 CGADVKAHHEV-CPKFPLTCDGCGKKKIPREKFQDHVKT 208
C + + H + P C CGK I F+ H +T
Sbjct: 458 CSSYFRIHERSHTGEKPYECKQCGKVFIRSSSFRLHERT 496
Score = 32.7 bits (73), Expect = 0.79
Identities = 22/85 (25%), Positives = 35/85 (41%), Gaps = 6/85 (7%)
Query: 113 TWKGTLKEYESCHEGRCPLMLTECPAC-KGLVRLGEKERHLEHECPERSLSCRHC-RAPC 170
++ +L+E+E H G P EC C K +R + H E+ C+ C +A
Sbjct: 513 SFSSSLREHEKIHTGNKPF---ECKQCGKAFLRSSQIRLHERTHTGEKPYQCKQCGKAFI 569
Query: 171 CGADVKAHHEV-CPKFPLTCDGCGK 194
+ + H + P C CGK
Sbjct: 570 SSSKFRMHERTHTGEKPYRCKQCGK 594
Score = 30.4 bits (67), Expect = 3.9
Identities = 29/111 (26%), Positives = 40/111 (36%), Gaps = 18/111 (16%)
Query: 121 YESCHEGRCPLMLTECPACKGLVRLGEKERHLEHE---CPERSLSCRHC-RAPCCGADVK 176
+E H G P EC C R EHE + C+ C +A + ++
Sbjct: 493 HERTHTGEKPY---ECKLCGKTFSFSSSLR--EHEKIHTGNKPFECKQCGKAFLRSSQIR 547
Query: 177 AHHEV-CPKFPLTCDGCGKKKIPREKFQDHVKT--------CGKCRVPCRF 218
H + P C CGK I KF+ H +T C +C RF
Sbjct: 548 LHERTHTGEKPYQCKQCGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRF 598
>gi|153070262 meprin A alpha [Homo sapiens]
Length = 746
Score = 43.5 bits (101), Expect = 4e-04
Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 8/85 (9%)
Query: 355 IWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNG-DGTGRGTHLSLFFVV 413
+W + +F++ + G + SP FY S GY + +Y N + +G +L L F V
Sbjct: 435 VWTVRNFSQVLENTSKG--DKLQSPRFYNSE-GYGFGVTLYPNSRESSG---YLRLAFHV 488
Query: 414 MKGPNDALLRWPF-NQKVTLMLLDQ 437
G NDA+L WP N++V + +LDQ
Sbjct: 489 CSGENDAILEWPVENRQVIITILDQ 513
>gi|170932473 zinc finger protein 786 [Homo sapiens]
Length = 782
Score = 43.5 bits (101), Expect = 4e-04
Identities = 36/121 (29%), Positives = 50/121 (41%), Gaps = 15/121 (12%)
Query: 111 GCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRL-GEKERHLEHECPERSLSCRHC-RA 168
G T + L E+ H G P +CP C RL G+ H ER C C +
Sbjct: 573 GFTRQSKLTEHLRVHSGERPF---QCPECNRSFRLKGQLLSHQRLHTGERPFQCPECDKR 629
Query: 169 PCCGADVKAHHEV-CPKFPLTCDGCGKKKIPREKFQDHVKT--------CGKCRVPCRFH 219
AD+KAH + + P +C+ CGK + K +H++T C KC R
Sbjct: 630 YRVKADMKAHQLLHSGEMPFSCE-CGKGFVKHSKLIEHIRTHTGEKPFQCPKCDKSFRLK 688
Query: 220 A 220
A
Sbjct: 689 A 689
Score = 38.9 bits (89), Expect = 0.011
Identities = 31/116 (26%), Positives = 47/116 (40%), Gaps = 8/116 (6%)
Query: 97 RREVESLPAVCPSDGCTWK--GTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEH 154
R + P CP G +++ L+ + H G P +EC +G + HL
Sbjct: 473 RLHTDEKPFQCPECGLSFRLESMLRAHRLRHGGERPFSCSECG--RGFTHQCKLREHLRV 530
Query: 155 ECPERSLSCRHC--RAPCCGADVKAH-HEVCPKFPLTCDGCGKKKIPREKFQDHVK 207
ER C C R G +KAH H + P +C CGK + K +H++
Sbjct: 531 HSGERPFQCLKCDKRFRLKGI-LKAHQHTHSKERPFSCGECGKGFTRQSKLTEHLR 585
Score = 34.3 bits (77), Expect = 0.27
Identities = 30/104 (28%), Positives = 40/104 (38%), Gaps = 11/104 (10%)
Query: 118 LKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHE---CPERSLSCRHCRAPCCGAD 174
L E+ H G P +CP C RL K + L H+ ER C C
Sbjct: 663 LIEHIRTHTGEKPF---QCPKCDKSFRL--KAQLLSHQGLHTGERPFHCPECDKNFRERG 717
Query: 175 VKAHHEVC--PKFPLTCDGCGKKKIPREKFQDHVKTCGK-CRVP 215
H+ P+ P C CGK I + K +H++ K C P
Sbjct: 718 HMLRHQRIHRPERPFACGDCGKGFIYKSKLAEHIRVHTKSCPAP 761
>gi|8923898 zinc finger protein 313 [Homo sapiens]
Length = 228
Score = 43.1 bits (100), Expect = 6e-04
Identities = 35/129 (27%), Positives = 46/129 (35%), Gaps = 19/129 (14%)
Query: 1 MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLAS 60
MAA G+ +L P LG ++ C C V +P Q CGH +CS CL
Sbjct: 1 MAAQQRDCGGAAQLAGPAAEADPLG-----RFTCPVCLEVYEKPVQVPCGHVFCSACLQE 55
Query: 61 ILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKE 120
L C C G+ +E R++ES C GC L +
Sbjct: 56 CLKPKKPVCGVC--RSALAPGVRAVE---------LERQIESTETSC--HGCRKNFFLSK 102
Query: 121 YESCHEGRC 129
S H C
Sbjct: 103 IRS-HVATC 110
>gi|219879806 TRAF-type zinc finger domain containing 1 [Homo
sapiens]
Length = 582
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/111 (23%), Positives = 39/111 (35%), Gaps = 25/111 (22%)
Query: 125 HEGRCPLMLTECPACKGLVRLGEKERHL------------------------EHECPERS 160
HE C + CP CK + E H+ E ECP R
Sbjct: 28 HEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRL 87
Query: 161 LSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGK 211
C+HC +K H + C C CG+ + ++ + H + CG+
Sbjct: 88 AVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKD-LKTHPEVCGR 137
>gi|5729828 TRAF-type zinc finger domain containing 1 [Homo sapiens]
Length = 582
Score = 42.4 bits (98), Expect = 0.001
Identities = 26/111 (23%), Positives = 39/111 (35%), Gaps = 25/111 (22%)
Query: 125 HEGRCPLMLTECPACKGLVRLGEKERHL------------------------EHECPERS 160
HE C + CP CK + E H+ E ECP R
Sbjct: 28 HEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHCQVTCKCNKKLEKRLLKKHEETECPLRL 87
Query: 161 LSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGK 211
C+HC +K H + C C CG+ + ++ + H + CG+
Sbjct: 88 AVCQHCDLELSILKLKEHEDYCGARTELCGNCGRNVLVKD-LKTHPEVCGR 137
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 41.2 bits (95), Expect = 0.002
Identities = 35/127 (27%), Positives = 47/127 (37%), Gaps = 24/127 (18%)
Query: 108 PSDGCTWKGTLKEYESCHEGRCP-----LMLTE----CPACKGLVRLGEKERHLEHECPE 158
P+ C W SC +CP L +TE CP C+G + GE+ P
Sbjct: 853 PAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHPEGSRWVPP 912
Query: 159 RSLSCRHC----------RAPC---CGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDH 205
S +C C R C C + H+ CP+ C+ G+K P E FQ
Sbjct: 913 DS-ACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCCPQCS-DCEHEGRKYEPGESFQPG 970
Query: 206 VKTCGKC 212
C C
Sbjct: 971 ADPCEVC 977
Score = 37.7 bits (86), Expect = 0.025
Identities = 38/143 (26%), Positives = 50/143 (34%), Gaps = 31/143 (21%)
Query: 108 PSDGCTWKGTLKEYESCHEGRC---------PLMLTECPACKGLVRLGEKERHLEHECPE 158
P D C L+ + C + C PL T CP C G G + H E
Sbjct: 209 PGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDGCFLNGRE--HRSGEPVG 266
Query: 159 RSLSCRHCRAPCCGADVKAHHEVCPKFPL------------TCDGC---GKKKIPREKFQ 203
C HCR C V+ CP P CDGC G + +E F+
Sbjct: 267 SGDPCSHCR--CANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFR 324
Query: 204 DHVKTCGKC-RVPCRFHAIGCLE 225
++ G C R C+ + C E
Sbjct: 325 --LQERGLCVRCSCQAGEVSCEE 345
Score = 33.5 bits (75), Expect = 0.46
Identities = 41/169 (24%), Positives = 57/169 (33%), Gaps = 36/169 (21%)
Query: 44 PFQAQCGHRYCSFCL----ASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARRE 99
P +C R C + + +L GPQ+C E + +L S A PD
Sbjct: 986 PPSLRCHRRQCPSLVGCPPSQLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPC---- 1041
Query: 100 VESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTE------CPACK----GLVRLGEKE 149
C TW L +++C E CPL CP C+ V G +
Sbjct: 1042 -----YTCQCQDLTW---LCIHQACPELSCPLSERHTPPGSCCPVCRAPTQSCVHQGREV 1093
Query: 150 RHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIP 198
E + SC C V+ + C PL+ CG K P
Sbjct: 1094 ASGERWTVDTCTSC-----SCMAGTVRCQSQRCS--PLS---CGPDKAP 1132
Score = 29.3 bits (64), Expect = 8.7
Identities = 43/175 (24%), Positives = 55/175 (31%), Gaps = 41/175 (23%)
Query: 64 SGPQNCAACVHEGIYEEGISILESSSAFPDNAARR------EVESLPAVCPSDGCTWKGT 117
SGP C + I EE + + S + P + + P CP C
Sbjct: 472 SGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAH--- 528
Query: 118 LKEYESCHEGRCPLMLTECPA-CKGLVRLGEKERHLEHECPERSLSCRHCR-----APC- 170
PL T CP C G G KE + P S CR CR C
Sbjct: 529 ------------PLPGTCCPNDCSGCA-FGGKEYPSGADFPHPSDPCRLCRCLSGNVQCL 575
Query: 171 --------CGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCR 217
C V E CP+ P GC + + Q++ G PCR
Sbjct: 576 ARRCVPLPCPEPVLLPGECCPQCPAPA-GCPRPGAAHARHQEYFSPPGD---PCR 626
>gi|23312364 ubiquitin-like with PHD and ring finger domains 2 [Homo
sapiens]
Length = 802
Score = 40.8 bits (94), Expect = 0.003
Identities = 15/49 (30%), Positives = 25/49 (51%)
Query: 27 KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHE 75
KLE ++C C+ ++ +P +C H C CL + +C AC H+
Sbjct: 726 KLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPACRHD 774
>gi|30023818 tripartite motif protein 50A [Homo sapiens]
Length = 487
Score = 40.8 bits (94), Expect = 0.003
Identities = 26/90 (28%), Positives = 36/90 (40%), Gaps = 18/90 (20%)
Query: 27 KLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILS--SGPQNCAACVHEGIYEEGISI 84
+LE C C V + P QCGH YC CL S+ C C
Sbjct: 9 ELEDWLQCPICLEVFKEPLMLQCGHSYCKGCLVSLSCHLDAELRCPVC---------RQA 59
Query: 85 LESSSAFPDNAARREVESL-------PAVC 107
++ SS+ P+ + R +E+L P VC
Sbjct: 60 VDGSSSLPNVSLARVIEALRLPGDPEPKVC 89
>gi|37595555 ring finger protein 125 [Homo sapiens]
Length = 232
Score = 40.8 bits (94), Expect = 0.003
Identities = 14/39 (35%), Positives = 22/39 (56%)
Query: 34 CSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAAC 72
C+ C VL +P + +CGH +C C+A+ L + C C
Sbjct: 37 CAVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYC 75
>gi|37655173 zinc finger protein 155 [Homo sapiens]
Length = 538
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/170 (24%), Positives = 60/170 (35%), Gaps = 18/170 (10%)
Query: 43 RPFQA-QCGHRYCS---FCLASILSSG--PQNCAACVHEGIYEEGISILESSSAFPDNAA 96
+P++ QCG + F ++ +G P NC C G S SS
Sbjct: 342 KPYRCEQCGKGFIGRLDFYKHQVVHTGEKPYNCKEC--------GKSFRWSSCLLNHQRV 393
Query: 97 RREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHEC 156
+S G L ++ H G P EC KG V + H
Sbjct: 394 HSGEKSFKCEECGKGFYTNSQLSSHQRSHSGEKPYKCEECG--KGYVTKFNLDLHQRVHT 451
Query: 157 PERSLSCRHCRAPCCGADVKAHHEV--CPKFPLTCDGCGKKKIPREKFQD 204
ER +C+ C A +H+ C K P C+ CGK+ + R +D
Sbjct: 452 GERPYNCKECGKNFSRASSILNHKRLHCQKKPFKCEDCGKRLVHRTYRKD 501
Score = 31.6 bits (70), Expect = 1.8
Identities = 23/90 (25%), Positives = 36/90 (40%), Gaps = 4/90 (4%)
Query: 118 LKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHC-RAPCCGADVK 176
L+ ++ H G P +C KG R H + E+ C C +A + +K
Sbjct: 219 LQTHQRVHTGEKPFKCEQCG--KGFSRRSALNVHRKLHTGEKPYICEACGKAFIHDSQLK 276
Query: 177 AHHEV-CPKFPLTCDGCGKKKIPREKFQDH 205
H + + P CD CGK R + + H
Sbjct: 277 EHKRIHTGEKPFKCDICGKTFYFRSRLKSH 306
>gi|37655171 zinc finger protein 155 [Homo sapiens]
Length = 538
Score = 40.4 bits (93), Expect = 0.004
Identities = 41/170 (24%), Positives = 60/170 (35%), Gaps = 18/170 (10%)
Query: 43 RPFQA-QCGHRYCS---FCLASILSSG--PQNCAACVHEGIYEEGISILESSSAFPDNAA 96
+P++ QCG + F ++ +G P NC C G S SS
Sbjct: 342 KPYRCEQCGKGFIGRLDFYKHQVVHTGEKPYNCKEC--------GKSFRWSSCLLNHQRV 393
Query: 97 RREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHEC 156
+S G L ++ H G P EC KG V + H
Sbjct: 394 HSGEKSFKCEECGKGFYTNSQLSSHQRSHSGEKPYKCEECG--KGYVTKFNLDLHQRVHT 451
Query: 157 PERSLSCRHCRAPCCGADVKAHHEV--CPKFPLTCDGCGKKKIPREKFQD 204
ER +C+ C A +H+ C K P C+ CGK+ + R +D
Sbjct: 452 GERPYNCKECGKNFSRASSILNHKRLHCQKKPFKCEDCGKRLVHRTYRKD 501
Score = 31.6 bits (70), Expect = 1.8
Identities = 23/90 (25%), Positives = 36/90 (40%), Gaps = 4/90 (4%)
Query: 118 LKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHC-RAPCCGADVK 176
L+ ++ H G P +C KG R H + E+ C C +A + +K
Sbjct: 219 LQTHQRVHTGEKPFKCEQCG--KGFSRRSALNVHRKLHTGEKPYICEACGKAFIHDSQLK 276
Query: 177 AHHEV-CPKFPLTCDGCGKKKIPREKFQDH 205
H + + P CD CGK R + + H
Sbjct: 277 EHKRIHTGEKPFKCDICGKTFYFRSRLKSH 306
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,334,184
Number of Sequences: 37866
Number of extensions: 961033
Number of successful extensions: 4335
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 423
Number of HSP's that attempted gapping in prelim test: 3597
Number of HSP's gapped (non-prelim): 1071
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.