Guide to the Human Genome
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Search of human proteins with 218505839

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
[Homo sapiens]
         (422 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor ...   880   0.0  
gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [H...   880   0.0  
gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor [...   816   0.0  
gi|22212918 ciliary neurotrophic factor receptor preproprotein [...   140   2e-33
gi|4502931 ciliary neurotrophic factor receptor preproprotein [H...   140   2e-33
gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo sapi...   126   4e-29
gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo sap...   119   4e-27
gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]      96   5e-20
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]              70   3e-12
gi|4506107 prolactin receptor [Homo sapiens]                           67   2e-11
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ...    54   3e-07
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ...    53   5e-07
gi|24497438 interleukin 12B precursor [Homo sapiens]                   50   4e-06
gi|115430248 gp130-like monocyte receptor [Homo sapiens]               48   2e-05
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s...    45   9e-05
gi|189083786 leukemia inhibitory factor receptor precursor [Homo...    45   9e-05
gi|27437045 colony stimulating factor 3 receptor isoform d precu...    44   3e-04
gi|24496783 colony stimulating factor 3 receptor isoform c precu...    44   3e-04
gi|27437042 colony stimulating factor 3 receptor isoform b precu...    44   3e-04
gi|4503081 colony stimulating factor 3 receptor isoform a precur...    44   3e-04
gi|156104903 myomesin 2 [Homo sapiens]                                 44   3e-04
gi|51093381 leptin receptor isoform 3 [Homo sapiens]                   44   4e-04
gi|51093379 leptin receptor isoform 2 [Homo sapiens]                   44   4e-04
gi|40254464 leptin receptor isoform 1 [Homo sapiens]                   44   4e-04
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]    44   4e-04
gi|144226847 obscurin-like 1 [Homo sapiens]                            43   6e-04
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]      43   6e-04
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]            42   0.001
gi|239752152 PREDICTED: hypothetical protein XP_002348153 [Homo ...    41   0.002
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...    41   0.002

>gi|218505839 interleukin 11 receptor, alpha isoform 1 precursor
           [Homo sapiens]
          Length = 422

 Score =  880 bits (2275), Expect = 0.0
 Identities = 422/422 (100%), Positives = 422/422 (100%)

Query: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF 60
           MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF
Sbjct: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF 60

Query: 61  RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC 120
           RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC
Sbjct: 61  RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC 120

Query: 121 QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC 180
           QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC
Sbjct: 121 QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC 180

Query: 181 VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW 240
           VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW
Sbjct: 181 VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW 240

Query: 241 TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD 300
           TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD
Sbjct: 241 TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD 300

Query: 301 AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR 360
           AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR
Sbjct: 301 AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR 360

Query: 361 DSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAP 420
           DSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAP
Sbjct: 361 DSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAP 420

Query: 421 NL 422
           NL
Sbjct: 421 NL 422


>gi|4758594 interleukin 11 receptor, alpha isoform 1 precursor [Homo
           sapiens]
          Length = 422

 Score =  880 bits (2275), Expect = 0.0
 Identities = 422/422 (100%), Positives = 422/422 (100%)

Query: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF 60
           MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF
Sbjct: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF 60

Query: 61  RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC 120
           RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC
Sbjct: 61  RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC 120

Query: 121 QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC 180
           QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC
Sbjct: 121 QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC 180

Query: 181 VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW 240
           VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW
Sbjct: 181 VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW 240

Query: 241 TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD 300
           TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD
Sbjct: 241 TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD 300

Query: 301 AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR 360
           AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR
Sbjct: 301 AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR 360

Query: 361 DSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAP 420
           DSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAP
Sbjct: 361 DSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVDRRPGAP 420

Query: 421 NL 422
           NL
Sbjct: 421 NL 422


>gi|22212922 interleukin 11 receptor, alpha isoform 2 precursor
           [Homo sapiens]
          Length = 390

 Score =  816 bits (2107), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF 60
           MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF
Sbjct: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF 60

Query: 61  RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC 120
           RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC
Sbjct: 61  RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARPVVSC 120

Query: 121 QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC 180
           QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC
Sbjct: 121 QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARC 180

Query: 181 VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW 240
           VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW
Sbjct: 181 VVHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASW 240

Query: 241 TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD 300
           TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD
Sbjct: 241 TYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLD 300

Query: 301 AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR 360
           AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR
Sbjct: 301 AGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHPRLLDHR 360

Query: 361 DSVEQVAVLASLGILSFLGLVAGALALGLW 390
           DSVEQVAVLASLGILSFLGLVAGALALGLW
Sbjct: 361 DSVEQVAVLASLGILSFLGLVAGALALGLW 390


>gi|22212918 ciliary neurotrophic factor receptor preproprotein
           [Homo sapiens]
          Length = 372

 Score =  140 bits (354), Expect = 2e-33
 Identities = 105/312 (33%), Positives = 148/312 (47%), Gaps = 26/312 (8%)

Query: 12  LVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGP 71
           ++A A A+V A    PQ    P VQY + G  V L C        V+W  +G       P
Sbjct: 12  VLAAAAAVVYAQRHSPQE--APHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDL---AP 66

Query: 72  DSGLGHELVLAQADSTDEGTYICQTLDG-ALGGTVTLQLGYPPARPVVSCQAADY-ENFS 129
           D   G +LVL   +    G Y C   D   L   V L +G PP  PV+SC++  Y + F 
Sbjct: 67  DLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFY 126

Query: 130 CTWSPSQISGLPT-RYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFW 188
           C+W       LPT  Y+ +    TVL               C +DP    RC +     +
Sbjct: 127 CSWH------LPTPTYIPNTFNVTVLHGSKIM--------VCEKDPALKNRCHIRYMHLF 172

Query: 189 S--QYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASW 246
           S  +Y+++++  N LG +   +     +I++PDPP+ +    VP  PRRL  +W  P++W
Sbjct: 173 STIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTW 232

Query: 247 PCQPHFLLKFRLQYRPAQHPAWSTVEPA-GLEEVITDAVAGLPHAVRVSARDFLDAGTWS 305
           P    F LKF L+YRP     W  VE + G    ITDA AG  + ++V+A+D  + GTWS
Sbjct: 233 PDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKD-NEIGTWS 291

Query: 306 TWSPEAWGTPST 317
            WS  A  TP T
Sbjct: 292 DWSVAAHATPWT 303


>gi|4502931 ciliary neurotrophic factor receptor preproprotein [Homo
           sapiens]
          Length = 372

 Score =  140 bits (354), Expect = 2e-33
 Identities = 105/312 (33%), Positives = 148/312 (47%), Gaps = 26/312 (8%)

Query: 12  LVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGP 71
           ++A A A+V A    PQ    P VQY + G  V L C        V+W  +G       P
Sbjct: 12  VLAAAAAVVYAQRHSPQE--APHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDL---AP 66

Query: 72  DSGLGHELVLAQADSTDEGTYICQTLDG-ALGGTVTLQLGYPPARPVVSCQAADY-ENFS 129
           D   G +LVL   +    G Y C   D   L   V L +G PP  PV+SC++  Y + F 
Sbjct: 67  DLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFY 126

Query: 130 CTWSPSQISGLPT-RYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFW 188
           C+W       LPT  Y+ +    TVL               C +DP    RC +     +
Sbjct: 127 CSWH------LPTPTYIPNTFNVTVLHGSKIM--------VCEKDPALKNRCHIRYMHLF 172

Query: 189 S--QYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASW 246
           S  +Y+++++  N LG +   +     +I++PDPP+ +    VP  PRRL  +W  P++W
Sbjct: 173 STIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTW 232

Query: 247 PCQPHFLLKFRLQYRPAQHPAWSTVEPA-GLEEVITDAVAGLPHAVRVSARDFLDAGTWS 305
           P    F LKF L+YRP     W  VE + G    ITDA AG  + ++V+A+D  + GTWS
Sbjct: 233 PDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKD-NEIGTWS 291

Query: 306 TWSPEAWGTPST 317
            WS  A  TP T
Sbjct: 292 DWSVAAHATPWT 303


>gi|4504673 interleukin 6 receptor isoform 1 precursor [Homo
           sapiens]
          Length = 468

 Score =  126 bits (316), Expect = 4e-29
 Identities = 128/435 (29%), Positives = 182/435 (41%), Gaps = 34/435 (7%)

Query: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58
           ++  C+ L+ +L A   AL  A   CP      GV    PG SV L CPGV   D   V 
Sbjct: 2   LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59

Query: 59  WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116
           W    +P     P   +G+G  L+L      D G Y C    G   GTV L +  PP  P
Sbjct: 60  WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117

Query: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171
            +SC + +   N  C W P     L T+ +   RK     A+  +        PC     
Sbjct: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170

Query: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230
                    V  G    S Y +++   + +G+  ++        IL+PDPP  + V +V 
Sbjct: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228

Query: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288
             PR L  +W  P SW     + L+F L+YR  +   ++T     L+   VI DA +GL 
Sbjct: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287

Query: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHT--QPEVEPQVDSPAPP 346
           H V++ A++    G WS WSPEA GTP T +  +  PA  ++ T  Q     + D     
Sbjct: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWTES--RSPPAENEVSTPMQALTTNKDDDNILF 345

Query: 347 RPSLQPHPRLLDHRDSVEQVAVLASLGILSFLGLVAGALALGL---W-LRLRRGGKDGSP 402
           R S       +    SV     L + G L+F  L+  A+ L     W LR  + GK    
Sbjct: 346 RDSANATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMH 405

Query: 403 KPGFLASVIPVDRRP 417
            P  L  ++P   RP
Sbjct: 406 PPYSLGQLVPERPRP 420


>gi|31317249 interleukin 6 receptor isoform 2 precursor [Homo
           sapiens]
          Length = 365

 Score =  119 bits (299), Expect = 4e-27
 Identities = 102/329 (31%), Positives = 143/329 (43%), Gaps = 26/329 (7%)

Query: 1   MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGD--PVS 58
           ++  C+ L+ +L A   AL  A   CP      GV    PG SV L CPGV   D   V 
Sbjct: 2   LAVGCALLAALLAAPGAAL--APRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVH 59

Query: 59  WFRDGEPKLLQGPD--SGLGHELVLAQADSTDEGTYICQTLDGALGGTVTLQLGYPPARP 116
           W    +P     P   +G+G  L+L      D G Y C    G   GTV L +  PP  P
Sbjct: 60  WVLR-KPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYRA-GRPAGTVHLLVDVPPEEP 117

Query: 117 VVSC-QAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP---- 171
            +SC + +   N  C W P     L T+ +   RK     A+  +        PC     
Sbjct: 118 QLSCFRKSPLSNVVCEWGPRSTPSLTTKAVLLVRKFQNSPAEDFQE-------PCQYSQE 170

Query: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRVESVP 230
                    V  G    S Y +++   + +G+  ++        IL+PDPP  + V +V 
Sbjct: 171 SQKFSCQLAVPEGDS--SFYIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVA 228

Query: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE--VITDAVAGLP 288
             PR L  +W  P SW     + L+F L+YR  +   ++T     L+   VI DA +GL 
Sbjct: 229 RNPRWLSVTWQDPHSWNSS-FYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLR 287

Query: 289 HAVRVSARDFLDAGTWSTWSPEAWGTPST 317
           H V++ A++    G WS WSPEA GTP T
Sbjct: 288 HVVQLRAQEEFGQGEWSEWSPEAMGTPWT 316


>gi|14577917 Epstein-Barr virus induced 3 precursor [Homo sapiens]
          Length = 229

 Score = 96.3 bits (238), Expect = 5e-20
 Identities = 71/218 (32%), Positives = 106/218 (48%), Gaps = 24/218 (11%)

Query: 112 PPAR---PVVSCQAADYE-NFSCTWS--PSQISGLPTRYLTSYRKKTVLGADSQRRSPST 165
           PPA    P V C+A+ Y     C+W+  P+  S  P  ++ +YR    LG  ++  S   
Sbjct: 24  PPAALTLPRVQCRASRYPIAVDCSWTLPPAPNSTSPVSFIATYR----LGMAARGHS--- 76

Query: 166 GPWPCPQDPLGAARCVVHGAEFWSQ--YRINVTEVNPLGASTRLLDVSLQSILRPDPPQG 223
             WPC Q    +  C +   + +S   Y +NVT V+P G+S+  +    + I++PDPP+G
Sbjct: 77  --WPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWGSSSSFVPFITEHIIKPDPPEG 134

Query: 224 LRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDA 283
           +R+   P   R+L+  W  P SWP    F LK+ ++Y+      +  V P      I  A
Sbjct: 135 VRLS--PLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKRQGAARFHRVGPIEATSFILRA 192

Query: 284 VAGLPHA---VRVSARDFLDAGTWSTWSPEAWGTPSTG 318
           V   P A   V+V+A+D  D G  S WS  A  T S G
Sbjct: 193 VR--PRARYYVQVAAQDLTDYGELSDWSLPATATMSLG 228


>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
          Length = 422

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 62/239 (25%), Positives = 100/239 (41%), Gaps = 30/239 (12%)

Query: 93  ICQTLDGALGGTVTLQLGYPPARPV-VSCQAADYENFSCTWSPSQ--ISGLPTRYLTSYR 149
           +C   DG++     L +G PP +PV +SC + + ++ +C W+P     + L T Y   Y+
Sbjct: 115 VCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYK 174

Query: 150 KKTVLGADSQRRSPSTGPWPC--PQDPLGAARCVVHGAEFWSQYRINVTEVNPLG-ASTR 206
            +     ++     + GP  C  P+D              ++ Y I V   N LG A + 
Sbjct: 175 LRWYGQDNTCEEYHTVGPHSCHIPKD-----------LALFTPYEIWVEATNRLGSARSD 223

Query: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLL--KFRLQYRPAQ 264
           +L + +  ++  DPP  + V  V G   +L   W  P   P    FL   K++++YR   
Sbjct: 224 VLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSP---PALKDFLFQAKYQIRYRVED 280

Query: 265 HPAWSTVEPAGLEEV--ITDAVAGLPHAVRVSARDF-----LDAGTWSTWS-PEAWGTP 315
              W  V+    +    +     G  + V+V    F       AG WS WS P A  TP
Sbjct: 281 SVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPTAASTP 339


>gi|4506107 prolactin receptor [Homo sapiens]
          Length = 622

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 59/208 (28%), Positives = 87/208 (41%), Gaps = 24/208 (11%)

Query: 112 PPARP-VVSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPC 170
           PP +P +  C++ + E F+C W P    GLPT Y  +Y            R   T    C
Sbjct: 27  PPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTY-----------HREGETLMHEC 75

Query: 171 PQDPLGAARCVVHGAEF---WSQYRINVTEVNPLGAS-TRLLDVSLQSILRPDPPQGLRV 226
           P    G       G ++   W  Y + V   N +G+S +  L V +  I++PDPP  L V
Sbjct: 76  PDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAV 135

Query: 227 ESVPGYPRR--LRASWTYPASWPCQP-HFLLKFRLQYRPAQHPAWSTVEPAG--LEEVIT 281
           E      R+  L   W+ P     +   F L + ++ +P +   W  +  AG   E  I 
Sbjct: 136 EVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWE-IHFAGQQTEFKIL 194

Query: 282 DAVAGLPHAVRVSARDFLDAGTWSTWSP 309
               G  + V+V  +   D G WS WSP
Sbjct: 195 SLHPGQKYLVQVRCKP--DHGYWSAWSP 220


>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
           [Homo sapiens]
          Length = 918

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 54/239 (22%), Positives = 89/239 (37%), Gaps = 24/239 (10%)

Query: 105 VTLQLGYPPARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSP 163
           +T+  G PP +P  +SC   + +   C W   + + L T +       T   AD + +  
Sbjct: 118 ITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRD 177

Query: 164 STGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTR-LLDVSLQSILRPDPPQ 222
           +  P  C  D         +   ++    + V   N LG  T   ++      ++P+PP 
Sbjct: 178 T--PTSCTVD---------YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPH 226

Query: 223 GLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE---- 278
            L V +       L+ +WT P+    +   +LK+ +QYR      WS + P         
Sbjct: 227 NLSVINSEELSSILKLTWTNPS---IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283

Query: 279 -VITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQL---HTQ 333
             + D      +  R+        G WS WS EA G        K    W ++   HTQ
Sbjct: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQ 342


>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
           [Homo sapiens]
          Length = 329

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 49/216 (22%), Positives = 82/216 (37%), Gaps = 21/216 (9%)

Query: 105 VTLQLGYPPARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSP 163
           +T+  G PP +P  +SC   + +   C W   + + L T +       T   AD + +  
Sbjct: 118 ITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRD 177

Query: 164 STGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTR-LLDVSLQSILRPDPPQ 222
           +  P  C  D         +   ++    + V   N LG  T   ++      ++P+PP 
Sbjct: 178 T--PTSCTVD---------YSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPH 226

Query: 223 GLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEE---- 278
            L V +       L+ +WT P+    +   +LK+ +QYR      WS + P         
Sbjct: 227 NLSVINSEELSSILKLTWTNPS---IKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283

Query: 279 -VITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWG 313
             + D      +  R+        G WS WS EA G
Sbjct: 284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319


>gi|24497438 interleukin 12B precursor [Homo sapiens]
          Length = 328

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 64/306 (20%), Positives = 107/306 (34%), Gaps = 61/306 (19%)

Query: 40  PGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHELVLAQADSTDEGTYIC----- 94
           PG  V L C      D ++W  D   ++L     G G  L +   +  D G Y C     
Sbjct: 42  PGEMVVLTCD-TPEEDGITWTLDQSSEVL-----GSGKTLTIQVKEFGDAGQYTCHKGGE 95

Query: 95  ----------QTLDGALGGTVTLQLGYPPARPVVSCQAADYEN-FSCTWSPSQISGLPTR 143
                     +  DG     +      P  +  + C+A +Y   F+C W           
Sbjct: 96  VLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWW----------- 144

Query: 144 YLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGA 203
            LT+          S R S       C    L A R  V G     +Y +   E +   A
Sbjct: 145 -LTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAER--VRGDNKEYEYSVECQEDSACPA 201

Query: 204 STRLLDVS-------------------LQSILRPDPPQGLRVESVPGYPRRLRASWTYPA 244
           +   L +                    ++ I++PDPP+ L+++ +    R++  SW YP 
Sbjct: 202 AEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKN-SRQVEVSWEYPD 260

Query: 245 SWPCQPH--FLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAG 302
           +W   PH  F L F +Q +          +    ++     +     ++ V A+D   + 
Sbjct: 261 TW-STPHSYFSLTFCVQVQGKSKR--EKKDRVFTDKTSATVICRKNASISVRAQDRYYSS 317

Query: 303 TWSTWS 308
           +WS W+
Sbjct: 318 SWSEWA 323


>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
          Length = 764

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 55/216 (25%), Positives = 84/216 (38%), Gaps = 32/216 (14%)

Query: 113 PARPV-VSCQAADYENFSCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCP 171
           PA+P  +SC     +N +CTWSP    G  T Y T Y  K       +  + +T      
Sbjct: 54  PAKPENISCVYYYRKNLTCTWSP----GKETSY-TQYTVKRTYAFGEKHDNCTTN--SST 106

Query: 172 QDPLGAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVP 230
            +   +    +        Y I V   N  G   + +    L++I + +PP+  RV+ V 
Sbjct: 107 SENRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVL 166

Query: 231 GYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPA-------------GLE 277
           G  R ++  W  P   P      LK+ L++R     +W  V  A             GL+
Sbjct: 167 GIKRMIQIEWIKPELAPVSSD--LKYTLRFRTVNSTSWMEVNFAKNRKDKNQTYNLTGLQ 224

Query: 278 EVITDAVAGLPHAVRVSARDFLDAGTWSTWSPEAWG 313
              T+ V  L  AV+       ++  WS WS E  G
Sbjct: 225 P-FTEYVIALRCAVK-------ESKFWSDWSQEKMG 252


>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 37/162 (22%), Positives = 65/162 (40%), Gaps = 10/162 (6%)

Query: 86  STDEGTYICQTLDGALGGTVTLQLGYPPARPV-VSCQAADYENFSCTWSPSQISGLPTRY 144
           S   GT +  T +  + GTV    GYPP  P  ++C+  D +   C+W+P +++ L    
Sbjct: 307 SASSGTNVVFTTEDNIFGTVIFA-GYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPR 365

Query: 145 LTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS 204
            TSY           R   +  P     +       ++   E    Y   +   NPLG S
Sbjct: 366 ATSYTLVESFSGKYVRLKRAEAP---TNESYQLLFQMLPNQEI---YNFTLNAHNPLGRS 419

Query: 205 TRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASW 246
              + V++   + P  P   +V+ +      ++ SW  P ++
Sbjct: 420 QSTILVNITEKVYPHTPTSFKVKDINS--TAVKLSWHLPGNF 459


>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
           sapiens]
          Length = 1097

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 37/162 (22%), Positives = 65/162 (40%), Gaps = 10/162 (6%)

Query: 86  STDEGTYICQTLDGALGGTVTLQLGYPPARPV-VSCQAADYENFSCTWSPSQISGLPTRY 144
           S   GT +  T +  + GTV    GYPP  P  ++C+  D +   C+W+P +++ L    
Sbjct: 307 SASSGTNVVFTTEDNIFGTVIFA-GYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPR 365

Query: 145 LTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGAS 204
            TSY           R   +  P     +       ++   E    Y   +   NPLG S
Sbjct: 366 ATSYTLVESFSGKYVRLKRAEAP---TNESYQLLFQMLPNQEI---YNFTLNAHNPLGRS 419

Query: 205 TRLLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASW 246
              + V++   + P  P   +V+ +      ++ SW  P ++
Sbjct: 420 QSTILVNITEKVYPHTPTSFKVKDINS--TAVKLSWHLPGNF 459


>gi|27437045 colony stimulating factor 3 receptor isoform d
           precursor [Homo sapiens]
          Length = 783

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 32/223 (14%)

Query: 105 VTLQLGYPPARP-VVSC-QAADYENFSCTWSPSQISGLPTRY-LTSYRKKTVLGADSQRR 161
           V L+ GYPPA P  +SC       +  C W P   + LPT + L S++ +     + Q +
Sbjct: 115 VELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSR----GNCQTQ 170

Query: 162 SPSTGPWPC-PQDPLGAARCVVHGAE--FWSQYRINVTEVNPLGAS-TRLLDVSLQSILR 217
             S     C P+D  G + C +       +    I V   N LG S +  L +    +++
Sbjct: 171 GDSI--LDCVPKD--GQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVK 226

Query: 218 PDPPQGLRV-----ESVPGYPRRLRASWTYPASWPCQP--HFLLKFRLQYRPAQHPA-WS 269
            +PP  LR      E+ P     L+  W      P QP  H   K  L+++P +  A W+
Sbjct: 227 LEPPM-LRTMDPSPEAAPPQAGCLQLCWE-----PWQPGLHINQKCELRHKPQRGEASWA 280

Query: 270 TVEPAGLEEVITDAVAGLP---HAVRVSARDFLDAGTWSTWSP 309
            V P  LE +  +    LP   + +++    +   G WS WSP
Sbjct: 281 LVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSP 323


>gi|24496783 colony stimulating factor 3 receptor isoform c
           precursor [Homo sapiens]
          Length = 863

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 32/223 (14%)

Query: 105 VTLQLGYPPARP-VVSC-QAADYENFSCTWSPSQISGLPTRY-LTSYRKKTVLGADSQRR 161
           V L+ GYPPA P  +SC       +  C W P   + LPT + L S++ +     + Q +
Sbjct: 115 VELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSR----GNCQTQ 170

Query: 162 SPSTGPWPC-PQDPLGAARCVVHGAE--FWSQYRINVTEVNPLGAS-TRLLDVSLQSILR 217
             S     C P+D  G + C +       +    I V   N LG S +  L +    +++
Sbjct: 171 GDSI--LDCVPKD--GQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVK 226

Query: 218 PDPPQGLRV-----ESVPGYPRRLRASWTYPASWPCQP--HFLLKFRLQYRPAQHPA-WS 269
            +PP  LR      E+ P     L+  W      P QP  H   K  L+++P +  A W+
Sbjct: 227 LEPPM-LRTMDPSPEAAPPQAGCLQLCWE-----PWQPGLHINQKCELRHKPQRGEASWA 280

Query: 270 TVEPAGLEEVITDAVAGLP---HAVRVSARDFLDAGTWSTWSP 309
            V P  LE +  +    LP   + +++    +   G WS WSP
Sbjct: 281 LVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSP 323


>gi|27437042 colony stimulating factor 3 receptor isoform b
           precursor [Homo sapiens]
          Length = 769

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 32/223 (14%)

Query: 105 VTLQLGYPPARP-VVSC-QAADYENFSCTWSPSQISGLPTRY-LTSYRKKTVLGADSQRR 161
           V L+ GYPPA P  +SC       +  C W P   + LPT + L S++ +     + Q +
Sbjct: 115 VELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSR----GNCQTQ 170

Query: 162 SPSTGPWPC-PQDPLGAARCVVHGAE--FWSQYRINVTEVNPLGAS-TRLLDVSLQSILR 217
             S     C P+D  G + C +       +    I V   N LG S +  L +    +++
Sbjct: 171 GDSI--LDCVPKD--GQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVK 226

Query: 218 PDPPQGLRV-----ESVPGYPRRLRASWTYPASWPCQP--HFLLKFRLQYRPAQHPA-WS 269
            +PP  LR      E+ P     L+  W      P QP  H   K  L+++P +  A W+
Sbjct: 227 LEPPM-LRTMDPSPEAAPPQAGCLQLCWE-----PWQPGLHINQKCELRHKPQRGEASWA 280

Query: 270 TVEPAGLEEVITDAVAGLP---HAVRVSARDFLDAGTWSTWSP 309
            V P  LE +  +    LP   + +++    +   G WS WSP
Sbjct: 281 LVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSP 323


>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
           [Homo sapiens]
          Length = 836

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 61/223 (27%), Positives = 95/223 (42%), Gaps = 32/223 (14%)

Query: 105 VTLQLGYPPARP-VVSC-QAADYENFSCTWSPSQISGLPTRY-LTSYRKKTVLGADSQRR 161
           V L+ GYPPA P  +SC       +  C W P   + LPT + L S++ +     + Q +
Sbjct: 115 VELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSR----GNCQTQ 170

Query: 162 SPSTGPWPC-PQDPLGAARCVVHGAE--FWSQYRINVTEVNPLGAS-TRLLDVSLQSILR 217
             S     C P+D  G + C +       +    I V   N LG S +  L +    +++
Sbjct: 171 GDSI--LDCVPKD--GQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVK 226

Query: 218 PDPPQGLRV-----ESVPGYPRRLRASWTYPASWPCQP--HFLLKFRLQYRPAQHPA-WS 269
            +PP  LR      E+ P     L+  W      P QP  H   K  L+++P +  A W+
Sbjct: 227 LEPPM-LRTMDPSPEAAPPQAGCLQLCWE-----PWQPGLHINQKCELRHKPQRGEASWA 280

Query: 270 TVEPAGLEEVITDAVAGLP---HAVRVSARDFLDAGTWSTWSP 309
            V P  LE +  +    LP   + +++    +   G WS WSP
Sbjct: 281 LVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSP 323


>gi|156104903 myomesin 2 [Homo sapiens]
          Length = 1465

 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 45/166 (27%), Positives = 64/166 (38%), Gaps = 16/166 (9%)

Query: 165 TGPW-PCPQDPLGAARCVVHGAEFWSQYRINVTEVNPLGASTRLLD---VSLQSILR-PD 219
           T  W PC   P+G  R VVHG     QY   V  VN +G S    +   + +Q+ L  P 
Sbjct: 653 TNLWEPCNHKPIGYNRFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKVQAALTVPS 712

Query: 220 PPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEV 279
            P G+ + +  G+   L   W  P      P  +L + L  R   H  W  V  +  +  
Sbjct: 713 HPYGITLLNCDGHSMTL--GWKVPKFSGGSP--ILGYYLDKREVHHKNWHEVNSSPSKPT 768

Query: 280 ITDA---VAGLPHAVRVSARDFLDAGTWSTWSP----EAWGTPSTG 318
           I        G  +  +++A +    G  S  S     EAW  P  G
Sbjct: 769 ILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMPEPG 814


>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
          Length = 958

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 45/216 (20%), Positives = 80/216 (37%), Gaps = 4/216 (1%)

Query: 118 VSCQAADY-ENFSCTWSPSQISGLPTRYLT-SYRKKTVLGADSQRRSPSTGPWPCPQDPL 175
           +SC+   Y    +C WS S I  L    L   Y + ++  +D     P + P  C     
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSD 493

Query: 176 GAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVPGYPR 234
           G   C+       S Y + +   + LG+  +    V   S+++P PP  ++ E       
Sbjct: 494 GFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGL 553

Query: 235 RLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVS 294
            L+ SW  P        F +++ L  +  Q   +   +       +        +AV+V 
Sbjct: 554 -LKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVR 612

Query: 295 ARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQL 330
            +     G WS WS  A+       +P   P + ++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRI 648



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHP 266
           L+ V   ++++PDPP GL +E        L+ SW+ P   P    + +K+          
Sbjct: 226 LMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVPFPLQYQVKYSENSTTVIRE 283

Query: 267 AWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWS-PEAWGTPSTGTIPKEI 324
           A   V    L  ++   + G  + V+V  +     G WS WS P  + T      P +I
Sbjct: 284 ADKIVSATSL--LVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKI 340


>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
          Length = 896

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 45/216 (20%), Positives = 80/216 (37%), Gaps = 4/216 (1%)

Query: 118 VSCQAADY-ENFSCTWSPSQISGLPTRYLT-SYRKKTVLGADSQRRSPSTGPWPCPQDPL 175
           +SC+   Y    +C WS S I  L    L   Y + ++  +D     P + P  C     
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSD 493

Query: 176 GAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVPGYPR 234
           G   C+       S Y + +   + LG+  +    V   S+++P PP  ++ E       
Sbjct: 494 GFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGL 553

Query: 235 RLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVS 294
            L+ SW  P        F +++ L  +  Q   +   +       +        +AV+V 
Sbjct: 554 -LKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVR 612

Query: 295 ARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQL 330
            +     G WS WS  A+       +P   P + ++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRI 648



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHP 266
           L+ V   ++++PDPP GL +E        L+ SW+ P   P    + +K+          
Sbjct: 226 LMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVPFPLQYQVKYSENSTTVIRE 283

Query: 267 AWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWS-PEAWGTPSTGTIPKEI 324
           A   V    L  ++   + G  + V+V  +     G WS WS P  + T      P +I
Sbjct: 284 ADKIVSATSL--LVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKI 340


>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
          Length = 1165

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 45/216 (20%), Positives = 80/216 (37%), Gaps = 4/216 (1%)

Query: 118 VSCQAADY-ENFSCTWSPSQISGLPTRYLT-SYRKKTVLGADSQRRSPSTGPWPCPQDPL 175
           +SC+   Y    +C WS S I  L    L   Y + ++  +D     P + P  C     
Sbjct: 434 ISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSD 493

Query: 176 GAARCVVHGAEFWSQYRINVTEVNPLGA-STRLLDVSLQSILRPDPPQGLRVESVPGYPR 234
           G   C+       S Y + +   + LG+  +    V   S+++P PP  ++ E       
Sbjct: 494 GFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGL 553

Query: 235 RLRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVEPAGLEEVITDAVAGLPHAVRVS 294
            L+ SW  P        F +++ L  +  Q   +   +       +        +AV+V 
Sbjct: 554 -LKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVR 612

Query: 295 ARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQL 330
            +     G WS WS  A+       +P   P + ++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRI 648



 Score = 38.5 bits (88), Expect = 0.012
 Identities = 30/119 (25%), Positives = 49/119 (41%), Gaps = 5/119 (4%)

Query: 207 LLDVSLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWPCQPHFLLKFRLQYRPAQHP 266
           L+ V   ++++PDPP GL +E        L+ SW+ P   P    + +K+          
Sbjct: 226 LMSVQPINMVKPDPPLGLHMEITD--DGNLKISWSSPPLVPFPLQYQVKYSENSTTVIRE 283

Query: 267 AWSTVEPAGLEEVITDAVAGLPHAVRVSARDFLDAGTWSTWS-PEAWGTPSTGTIPKEI 324
           A   V    L  ++   + G  + V+V  +     G WS WS P  + T      P +I
Sbjct: 284 ADKIVSATSL--LVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKI 340


>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
          Length = 862

 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 34/123 (27%), Positives = 53/123 (43%), Gaps = 10/123 (8%)

Query: 189 SQYRINVTEVNPLGASTRLLDV-SLQSILRPDPPQGLRVESVPGYPRRLRASWTYPASWP 247
           S +   VT VN LG+S+ L    +   I+RP PP  +R++       R    W       
Sbjct: 194 SNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPWDIRIKFQKASVSRCTLYWR------ 247

Query: 248 CQPHFLLKFRLQYRPAQHPAWSTVE--PAGLEEVITDAVAGLPHAVRVSARDFLDAGTWS 305
                +L  RL+YRP+    W+ V    A     + D      +  ++S++  L  G+WS
Sbjct: 248 -DEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWS 306

Query: 306 TWS 308
            WS
Sbjct: 307 DWS 309


>gi|144226847 obscurin-like 1 [Homo sapiens]
          Length = 1896

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 7/85 (8%)

Query: 35   VQYGQPGRSVKLCCPGVTAGDPVSWFRDG----EPKLLQGPDSGLGHELVLAQADSTDEG 90
            + +G PGR V+L C    AG  V W++DG        LQ    G    L L  A   D G
Sbjct: 1091 LHFGAPGR-VELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAG 1149

Query: 91   TYICQTLDGALGGTVTLQLGYPPAR 115
             Y+C+T   A+  T  + L  PP +
Sbjct: 1150 EYVCETRHEAI--TFNVILAEPPVQ 1172



 Score = 38.1 bits (87), Expect = 0.015
 Identities = 31/90 (34%), Positives = 41/90 (45%), Gaps = 7/90 (7%)

Query: 40   PGRSVKLCCPGVTAGDPVSWFRDGEP----KLLQGPDSGLGHELVLAQADSTDEGTYICQ 95
            PG  V L C    AG PV W  +G P    + L+    G    L +  A     G Y CQ
Sbjct: 1187 PGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQ 1246

Query: 96   T--LDGALGGTVTLQLGYPPARPVVSCQAA 123
            +    GA   + T+Q+  PP R VV+ +AA
Sbjct: 1247 SGAAPGAPSLSFTVQVAEPPVR-VVAPEAA 1275



 Score = 33.5 bits (75), Expect = 0.37
 Identities = 19/57 (33%), Positives = 27/57 (47%), Gaps = 4/57 (7%)

Query: 44  VKLCCPGVTAGDPVSWFRDG----EPKLLQGPDSGLGHELVLAQADSTDEGTYICQT 96
           V L C       P +W++DG    E +LL     G  H L+L +A   D G + C+T
Sbjct: 734 VVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRT 790



 Score = 32.7 bits (73), Expect = 0.64
 Identities = 20/59 (33%), Positives = 27/59 (45%), Gaps = 4/59 (6%)

Query: 40   PGRSVKLCCPGVTAGDPVSWFRDGEPKLLQG----PDSGLGHELVLAQADSTDEGTYIC 94
            PG  ++L       G PV W++DGE    QG      +G    L +  A S D G Y+C
Sbjct: 1283 PGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLC 1341



 Score = 32.3 bits (72), Expect = 0.83
 Identities = 26/78 (33%), Positives = 33/78 (42%), Gaps = 6/78 (7%)

Query: 44   VKLCCPGVTAGDPVSWFRDG----EPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDG 99
            V L C       PV W++DG    E + L     G    LVL  A   D G ++C   D 
Sbjct: 1007 VVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDD 1066

Query: 100  ALGGTVTLQLGYPPARPV 117
            +   TVT+    PP R V
Sbjct: 1067 SAFFTVTVTA--PPERIV 1082



 Score = 31.6 bits (70), Expect = 1.4
 Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 9/67 (13%)

Query: 41  GRSVKLCCPGVTAGDP---VSWFRDGEP----KLLQGPDSGLGHELVLAQADSTDEGTYI 93
           G   +L C  V  G+P   V W + G+     + L  P  G  H L+L  A  TD G Y+
Sbjct: 26  GAEAELKC--VVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTAALPTDAGVYV 83

Query: 94  CQTLDGA 100
           C+  + A
Sbjct: 84  CRARNAA 90



 Score = 30.0 bits (66), Expect = 4.1
 Identities = 25/77 (32%), Positives = 34/77 (44%), Gaps = 8/77 (10%)

Query: 44  VKLCCPGVTAGDPVSWFRDGEPKLLQGPDSGLGHE-----LVLAQADSTDEGTYICQTLD 98
           V L C        V W +DGE ++++ P   L  E     LVL      D G Y+C+  D
Sbjct: 916 VVLTCELCRPWAEVRWTKDGE-EVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDD 974

Query: 99  GALGGTVTLQLGYPPAR 115
            +   TVT+    PP R
Sbjct: 975 ESASFTVTVT--EPPVR 989



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 22/69 (31%), Positives = 28/69 (40%), Gaps = 6/69 (8%)

Query: 32   PPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGP-----DSGLGHELVLAQADS 86
            PP  +    GR   L      +G  V W R+G  +L  G        G  H LV+     
Sbjct: 1814 PPREKTVLVGRRAVLEVTVSRSGGHVCWLREGA-ELCPGDKYEMRSHGPTHSLVIHDVRP 1872

Query: 87   TDEGTYICQ 95
             D+GTY CQ
Sbjct: 1873 EDQGTYCCQ 1881


>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
          Length = 1007

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 20/45 (44%), Positives = 31/45 (68%), Gaps = 1/45 (2%)

Query: 57  VSWFRDGEPKLLQ-GPDSGLGHELVLAQADSTDEGTYICQTLDGA 100
           VSW++DG+P  LQ G  +  G  L++A+A+ +DEGTY+C   + A
Sbjct: 169 VSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGTYMCVATNSA 213


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 39/169 (23%), Positives = 72/169 (42%), Gaps = 9/169 (5%)

Query: 182 VHGAEFWSQYRINVTEVNPLGASTRLLDVSLQSI--LRPDPPQGLRVESVPGYPRRLRAS 239
           + G + +++Y +     N  G      D+++ ++  +   PPQ + +E V    R ++ S
Sbjct: 585 LEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNS--RSIKVS 642

Query: 240 WTYPASWPCQPHFLLKFRLQYRPA-QHPAWSTVEPAGLEEVITDAVAGLPHAVRVSARDF 298
           W  P S   Q  F+  +++++R   +     T+EP  L  + T    G  ++ +VSA   
Sbjct: 643 WLPPPSGT-QNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTV 701

Query: 299 LDAGTWSTWSPEAWGTPSTGTIPKEIPAW-GQLHTQPEVEPQVDSPAPP 346
              G  S W      TP       ++P     LH +P+    + S  PP
Sbjct: 702 NGTGPPSNWYTAE--TPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPP 748


>gi|239752152 PREDICTED: hypothetical protein XP_002348153 [Homo
           sapiens]
          Length = 264

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 35/137 (25%), Positives = 51/137 (37%), Gaps = 37/137 (27%)

Query: 19  LVSASSPCPQAWG------PPGVQYGQPGRSVKLCCPGVTAG---DPVSWFRD------- 62
           L++  + C  +W       PP    G PG+ V + C G ++    + V+W++        
Sbjct: 33  LLTLLTHCAGSWAQSVLTQPPSAS-GTPGQRVTISCSGSSSNIGSNTVNWYQQLPGTAPK 91

Query: 63  -----------GEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDGAL---------G 102
                      G P    G  SG    L ++   S DE  Y C   D +L         G
Sbjct: 92  LLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADYYCAAWDDSLNGPTCWVFGG 151

Query: 103 GTVTLQLGYPPARPVVS 119
           GT    LG P A P V+
Sbjct: 152 GTKLTVLGQPKAAPSVT 168


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
           1 precursor [Homo sapiens]
          Length = 1907

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 77/302 (25%), Positives = 119/302 (39%), Gaps = 50/302 (16%)

Query: 14  AVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWFRDGEPKLLQGPDS 73
           A A   V      P+   PP  Q   PG SV L C  V A  P   +  G  +L +  + 
Sbjct: 219 APANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEM 278

Query: 74  GLGHELVLAQADSTDEGTYICQTLD--GALGGT--VTLQ-LGYPPARPVVSCQAADYENF 128
            +G   VL  ++      Y C  +   G +  T  VT++ L  PP   VV+   A   + 
Sbjct: 279 PVGRN-VLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTA--TSV 335

Query: 129 SCTWSPSQISGLPTRYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGAARCVVHGAEFW 188
           + TW  S  S   T Y   Y           R + + GP+    D +   R  + G   +
Sbjct: 336 TLTWD-SGNSEPVTYYGIQY-----------RAAGTEGPFQ-EVDGVATTRYSIGGLSPF 382

Query: 189 SQYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRV---ESVPGYP-----RRLRASW 240
           S+Y   V  VN +G              R  P + +R    E  P  P      R+ ++ 
Sbjct: 383 SEYAFRVLAVNSIG--------------RGPPSEAVRARTGEQAPSSPPRRVQARMLSAS 428

Query: 241 TYPASW--PCQPHFLLK-FRLQYRP-AQHP--AWSTVE-PAGLEEVITDAVAGLPHAVRV 293
           T    W  P +P+ L++ +R+ Y P ++ P  AW      AGL   +   + G+ +++RV
Sbjct: 429 TMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRV 488

Query: 294 SA 295
            A
Sbjct: 489 LA 490


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,222,284
Number of Sequences: 37866
Number of extensions: 1210732
Number of successful extensions: 5142
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 4693
Number of HSP's gapped (non-prelim): 583
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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