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Search of human proteins with 218083800
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218083800 Rho GTPase-activating protein isoform 1 [Homo
sapiens]
(2087 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens] 4237 0.0
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens] 3527 0.0
gi|23510413 sorting nexin 26 [Homo sapiens] 669 0.0
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens] 354 4e-97
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 346 1e-94
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 346 1e-94
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 132 5e-30
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 132 5e-30
gi|188497642 ARHGAP15 [Homo sapiens] 122 3e-27
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 122 4e-27
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 121 6e-27
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 121 6e-27
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 120 2e-26
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 120 2e-26
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 115 4e-25
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 115 4e-25
gi|229094128 active breakpoint cluster region-related protein i... 111 6e-24
gi|38679957 active breakpoint cluster region-related protein is... 111 6e-24
gi|38679954 active breakpoint cluster region-related protein is... 111 6e-24
gi|54860079 nadrin isoform 1 [Homo sapiens] 108 7e-23
gi|54860105 nadrin isoform 2 [Homo sapiens] 108 7e-23
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 104 1e-21
gi|85815829 SH3-domain binding protein 1 [Homo sapiens] 103 1e-21
gi|208022687 GTPase regulator associated with the focal adhesion... 101 7e-21
gi|7662208 GTPase regulator associated with the focal adhesion k... 101 7e-21
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 97 1e-19
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 97 1e-19
gi|156119615 myosin IXA [Homo sapiens] 97 2e-19
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 95 6e-19
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa... 95 8e-19
>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
Length = 2087
Score = 4237 bits (10988), Expect = 0.0
Identities = 2087/2087 (100%), Positives = 2087/2087 (100%)
Query: 1 METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNV 60
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNV
Sbjct: 1 METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNV 60
Query: 61 HPRERPDWEETLSAMARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAEC 120
HPRERPDWEETLSAMARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAEC
Sbjct: 61 HPRERPDWEETLSAMARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAEC 120
Query: 121 AHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD 180
AHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
Sbjct: 121 AHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD 180
Query: 181 KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWME 240
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWME
Sbjct: 181 KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWME 240
Query: 241 IDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWW 300
IDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWW
Sbjct: 241 IDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWW 300
Query: 301 RGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLK 360
RGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLK
Sbjct: 301 RGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLK 360
Query: 361 QRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRH 420
QRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRH
Sbjct: 361 QRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRH 420
Query: 421 EFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLI 480
EFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLI
Sbjct: 421 EFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLI 480
Query: 481 KIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACF 540
KIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACF
Sbjct: 481 KIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACF 540
Query: 541 SGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTL 600
SGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTL
Sbjct: 541 SGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTL 600
Query: 601 EEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSW 660
EEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSW
Sbjct: 601 EEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSW 660
Query: 661 RSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDS 720
RSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDS
Sbjct: 661 RSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDS 720
Query: 721 KLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAED 780
KLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAED
Sbjct: 721 KLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAED 780
Query: 781 VDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGS 840
VDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGS
Sbjct: 781 VDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGS 840
Query: 841 SQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLS 900
SQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLS
Sbjct: 841 SQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLS 900
Query: 901 KSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMK 960
KSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMK
Sbjct: 901 KSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMK 960
Query: 961 TNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQD 1020
TNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQD
Sbjct: 961 TNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQD 1020
Query: 1021 SVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATT 1080
SVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATT
Sbjct: 1021 SVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATT 1080
Query: 1081 EDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGE 1140
EDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGE
Sbjct: 1081 EDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGE 1140
Query: 1141 QHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQ 1200
QHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQ
Sbjct: 1141 QHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQ 1200
Query: 1201 DQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTAT 1260
DQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTAT
Sbjct: 1201 DQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTAT 1260
Query: 1261 MTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPV 1320
MTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPV
Sbjct: 1261 MTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPV 1320
Query: 1321 VGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQP 1380
VGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQP
Sbjct: 1321 VGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQP 1380
Query: 1381 GLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNY 1440
GLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNY
Sbjct: 1381 GLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNY 1440
Query: 1441 HSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPNC 1500
HSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPNC
Sbjct: 1441 HSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPNC 1500
Query: 1501 QYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSS 1560
QYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSS
Sbjct: 1501 QYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSS 1560
Query: 1561 LSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQY 1620
LSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQY
Sbjct: 1561 LSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQY 1620
Query: 1621 KPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRP 1680
KPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRP
Sbjct: 1621 KPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRP 1680
Query: 1681 LHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVKHTYT 1740
LHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVKHTYT
Sbjct: 1681 LHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVKHTYT 1740
Query: 1741 SWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGK 1800
SWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGK
Sbjct: 1741 SWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGK 1800
Query: 1801 TGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQS 1860
TGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQS
Sbjct: 1801 TGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQS 1860
Query: 1861 SLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSY 1920
SLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSY
Sbjct: 1861 SLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSY 1920
Query: 1921 HNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKEEEHLTQSIVPP 1980
HNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKEEEHLTQSIVPP
Sbjct: 1921 HNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKEEEHLTQSIVPP 1980
Query: 1981 PKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVF 2040
PKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVF
Sbjct: 1981 PKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVF 2040
Query: 2041 GGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE 2087
GGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE
Sbjct: 2041 GGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE 2087
>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
Length = 1738
Score = 3527 bits (9145), Expect = 0.0
Identities = 1738/1738 (100%), Positives = 1738/1738 (100%)
Query: 350 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 409
MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS
Sbjct: 1 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 60
Query: 410 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 469
GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA
Sbjct: 61 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 120
Query: 470 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 529
VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL
Sbjct: 121 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 180
Query: 530 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 589
LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL
Sbjct: 181 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 240
Query: 590 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 649
VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ
Sbjct: 241 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 300
Query: 650 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 709
NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES
Sbjct: 301 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 360
Query: 710 LTSLHAVDGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHI 769
LTSLHAVDGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHI
Sbjct: 361 LTSLHAVDGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHI 420
Query: 770 PALMSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKP 829
PALMSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKP
Sbjct: 421 PALMSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKP 480
Query: 830 SANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVY 889
SANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVY
Sbjct: 481 SANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVY 540
Query: 890 AFSPKIGRKLSKSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDAT 949
AFSPKIGRKLSKSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDAT
Sbjct: 541 AFSPKIGRKLSKSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDAT 600
Query: 950 NRSPTQIVKMKTNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQ 1009
NRSPTQIVKMKTNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQ
Sbjct: 601 NRSPTQIVKMKTNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQ 660
Query: 1010 TGAVTHDPPQDSVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGY 1069
TGAVTHDPPQDSVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGY
Sbjct: 661 TGAVTHDPPQDSVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGY 720
Query: 1070 TNYGDIAVATTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGD 1129
TNYGDIAVATTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGD
Sbjct: 721 TNYGDIAVATTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGD 780
Query: 1130 PTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGK 1189
PTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGK
Sbjct: 781 PTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGK 840
Query: 1190 NSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPS 1249
NSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPS
Sbjct: 841 NSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPS 900
Query: 1250 GSPEENTSTATMTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPP 1309
GSPEENTSTATMTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPP
Sbjct: 901 GSPEENTSTATMTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPP 960
Query: 1310 PSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAA 1369
PSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAA
Sbjct: 961 PSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAA 1020
Query: 1370 AQCPMATAVQPGLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHS 1429
AQCPMATAVQPGLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHS
Sbjct: 1021 AQCPMATAVQPGLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHS 1080
Query: 1430 SSADATSSSNYHSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPD 1489
SSADATSSSNYHSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPD
Sbjct: 1081 SSADATSSSNYHSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPD 1140
Query: 1490 NCLHFNMTPNCQYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHS 1549
NCLHFNMTPNCQYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHS
Sbjct: 1141 NCLHFNMTPNCQYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHS 1200
Query: 1550 KPCSRVEYVSSLSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDE 1609
KPCSRVEYVSSLSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDE
Sbjct: 1201 KPCSRVEYVSSLSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDE 1260
Query: 1610 PAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCD 1669
PAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCD
Sbjct: 1261 PAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCD 1320
Query: 1670 VDAYGTVQLRPLHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSM 1729
VDAYGTVQLRPLHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSM
Sbjct: 1321 VDAYGTVQLRPLHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSM 1380
Query: 1730 PPAADVKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYV 1789
PPAADVKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYV
Sbjct: 1381 PPAADVKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYV 1440
Query: 1790 IHLRSKSDPGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQ 1849
IHLRSKSDPGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQ
Sbjct: 1441 IHLRSKSDPGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQ 1500
Query: 1850 PEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSK 1909
PEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSK
Sbjct: 1501 PEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSK 1560
Query: 1910 GIPDTSEPVSYHNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKE 1969
GIPDTSEPVSYHNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKE
Sbjct: 1561 GIPDTSEPVSYHNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKE 1620
Query: 1970 EEHLTQSIVPPPKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDY 2029
EEHLTQSIVPPPKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDY
Sbjct: 1621 EEHLTQSIVPPPKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDY 1680
Query: 2030 HSLPQHQRGVFGGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE 2087
HSLPQHQRGVFGGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE
Sbjct: 1681 HSLPQHQRGVFGGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE 1738
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 669 bits (1725), Expect = 0.0
Identities = 367/670 (54%), Positives = 463/670 (69%), Gaps = 61/670 (9%)
Query: 75 MARGADVPEIPGDLT---LKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFG 131
+AR D + PG+ + L T G S+K K K+L +G FP++A+CAHFHYENV+FG
Sbjct: 2 VARSTDSLDGPGEGSVQPLPTAGGP-SVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFG 60
Query: 132 SIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRR 191
IQL LS ++ +G ELV+ VQ+ CQG+SW V RSY+DFR LD HLH CI+DRR
Sbjct: 61 HIQLLLSPDREGPSLSG--ENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRR 118
Query: 192 FSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVH 251
FS L ELP + + + +L+ YL LS + + +NCGP LTWME+DN G LL+
Sbjct: 119 FSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLS 178
Query: 252 EESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLF 311
EE+S+N PAV AAHVIKRYTA+APDEL+ EVGDIVSVIDMPP +WWRGK GFQVG F
Sbjct: 179 EEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFF 238
Query: 312 PGHCVELINQK-----------------VPQ---SVTNSVPKPVSKKHGKLITFLRTFMK 351
P CVEL ++ PQ S+T++VP+P GKL LRTFM+
Sbjct: 239 PSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRP----RGKLAGLLRTFMR 294
Query: 352 SRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGV 411
SRP++Q+L+QRGIL++RVFGCDLGEHL NSG +VPQVL+ C+ FIE +G+VDGIYRLSGV
Sbjct: 295 SRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGV 354
Query: 412 ASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVS 471
+SNIQRLRHEFDSE +P+L+ ++QDIHSV SLCKLYFRELPNPLLTYQLY KFS+A+S
Sbjct: 355 SSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMS 414
Query: 472 AATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLR 531
+EERL+++HDVIQQLPPPHYRTLE+L+RHL+ +A + + T+MHA+NLAIVWAPNLLR
Sbjct: 415 VPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLR 474
Query: 532 SKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQE--GAASLSRPKSLL 589
S ++ES G AAF EVR+QSVVVEF+L HVDVLFS + A + G L RPKSL
Sbjct: 475 SMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLA 534
Query: 590 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 649
S PST+LLTLEEAQARTQ ++ +P TE + PA+ P ER++ +
Sbjct: 535 GSCPSTRLLTLEEAQARTQGRLGTP--TEP---TTPKAPAS-----------PAERRKGE 578
Query: 650 --NKMKKSPVGSWRSFFNLGKSSSVSKRK----LQRNESEPSEMKAMALKGGRAEG-TLR 702
K +K SW++FF LG+ SV ++K L + P G R + TLR
Sbjct: 579 RGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQP------SGSRPDTVTLR 632
Query: 703 SAKSEESLTS 712
SAKSEESL+S
Sbjct: 633 SAKSEESLSS 642
Score = 43.1 bits (100), Expect = 0.003
Identities = 19/26 (73%), Positives = 22/26 (84%)
Query: 1032 PPPPPKNVARMLALALAESAQQASTQ 1057
PPPPPKN AR++ALALAE AQQ + Q
Sbjct: 728 PPPPPKNPARLMALALAERAQQVAEQ 753
>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
Length = 1444
Score = 354 bits (909), Expect = 4e-97
Identities = 290/839 (34%), Positives = 419/839 (49%), Gaps = 97/839 (11%)
Query: 350 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 409
MK++ KQKLK++G FGCDL E+L +SG +VP VL+SC FIE +GIVDGIYRLS
Sbjct: 1 MKNKGAKQKLKRKGAAS--AFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLS 58
Query: 410 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 469
GV SNIQRLR EF S+ PDLT+E Y+QDIH VGSLCKLYFRELPNPLLTY+LYEKF++A
Sbjct: 59 GVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEA 118
Query: 470 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 529
VS +E +L +I +VIQ+LPP HYRTLE+L+RHL+ +A + S TNMHA+NLA+VWAPNL
Sbjct: 119 VSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNL 178
Query: 530 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRP--KS 587
LRSK+IE+ +G AAF+ VR+Q VV+EFILNHVD +F+ +++ +RP KS
Sbjct: 179 LRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDE---NRPIMKS 235
Query: 588 LLVSSPS--TKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLER 645
L + + S KL++LEEAQAR+ A N P E + + E + FHT++E P +
Sbjct: 236 LTLPALSLPMKLVSLEEAQARSLA-TNHPARKERRENSLPEIVPPMGTLFHTVLELPDNK 294
Query: 646 KRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAK 705
++ +K KK W+S FNLG+S S SK KL RN S + ++++ + T+R AK
Sbjct: 295 RKLSSKSKK-----WKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVE----KATIRPAK 345
Query: 706 SEESLTSLHAVDGDSKLFRPRRPRSSSDALSAS-FNGEMLGNRCNSYDNLPHDNESEEEG 764
S +SL S+ ++K R + + A+ + G+ C D + E +EG
Sbjct: 346 SMDSLCSVPVEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSC---DLTKQEGEWGQEG 402
Query: 765 GLLHIPALMSPHSAE---DVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDS 821
P AE DV + A P + P + E ++ L
Sbjct: 403 ---------MPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKMLGM 453
Query: 822 PGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPS 881
S D PS K T SS Q S + + E + L +S +S P
Sbjct: 454 FYTSNDSPS---KSVFT-SSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTPC 509
Query: 882 SFTEKVVYAFS---------------PKIGRKL-SKSPSMSISEPISVTLPPRVSEVIGT 925
K + + S P+ + L +++ + S+ + + V E GT
Sbjct: 510 RTPPKELQSLSSLEEFSFHGSESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEAPGT 569
Query: 926 V--SNTTAQNASSSTWDKCVEERDATNRSPTQIVKMKTNETVAQEAYE------SEVQPL 977
V S +Q + +K E +++ ++ K E V +E E S +Q
Sbjct: 570 VECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESSTLQES 629
Query: 978 DQVAAEEVELPGKEDQSVSSS--------QSKAVASGQTQTG----AVTHDPPQDSVPVS 1025
+ AE V L ++ ++++ + K + S + + A+ P Q + S
Sbjct: 630 PRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPIQPILESS 689
Query: 1026 SVSLIPPPPP--------PKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAV 1077
IP PP P V+ L + + A Q STQ G S A +
Sbjct: 690 LGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQ-STQ-----GASTAASREKPE--- 740
Query: 1078 ATTEDNLSSSYSAVA-LDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNT 1135
E L +++A L+ F+ P Q ++ PGN PLP P +T
Sbjct: 741 --PEQGLHPDLASLAPLEIVPFEKASP--QATVEVGGPGNLSPPLPPAPPPPTPLEEST 795
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 346 bits (888), Expect = 1e-94
Identities = 200/383 (52%), Positives = 256/383 (66%), Gaps = 31/383 (8%)
Query: 350 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 409
MKSR QK K++G KERVFGCDL EHL +SG EVPQVL+SC F+E YG+VDGIYRLS
Sbjct: 1 MKSR---QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLS 57
Query: 410 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 469
GV+SNIQ+LR EF+SE PDL ++ Y+QDIH V SLCK YFRELP+PLLTY+LY+KF++A
Sbjct: 58 GVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEA 117
Query: 470 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 529
V + ERL+KI +V+++LP P+YRTLEFLMRHL +A + + TNMHA+NLAIVWAPNL
Sbjct: 118 VGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNL 177
Query: 530 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 589
LRSK IE++ F+GTAAFMEVR+QS+VVEFIL HVD LF G A S +S
Sbjct: 178 LRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGG--------AALSGGEVESGW 229
Query: 590 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 649
S P T+ E + P + ++ G+GP ++ +HTIIE +++
Sbjct: 230 RSLPGTRASGSPEDLMPRPLPYHLPSI-----LQAGDGPPQMR-PYHTIIEIAEHKRKGS 283
Query: 650 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 709
K++K WRS FNLG+S +KRKL R +E E K+ +GTLR AKS +S
Sbjct: 284 LKVRK-----WRSIFNLGRSGHETKRKLPRG-AEDREDKS-------NKGTLRPAKSMDS 330
Query: 710 LT-SLHAVDGDSKLFRPRRPRSS 731
L+ + A D L P PR S
Sbjct: 331 LSAAAGASDEPEGLVGPSSPRPS 353
Score = 32.3 bits (72), Expect = 5.0
Identities = 28/113 (24%), Positives = 40/113 (35%), Gaps = 9/113 (7%)
Query: 1269 ATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVVGQVQAAT 1328
A Q ++A W+V E + R P PP P + E P
Sbjct: 644 ALGQGGEEQACWEVGEDKQAEPGGRLDI-REEAEGTPQPPQPEEMEPEGQPSPDGCLCPC 702
Query: 1329 NIGLNNSH--------KVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCP 1373
++GL +VQ V VP PP+P+ P++ A A CP
Sbjct: 703 SLGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCP 755
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 346 bits (888), Expect = 1e-94
Identities = 200/383 (52%), Positives = 256/383 (66%), Gaps = 31/383 (8%)
Query: 350 MKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLS 409
MKSR QK K++G KERVFGCDL EHL +SG EVPQVL+SC F+E YG+VDGIYRLS
Sbjct: 1 MKSR---QKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGVVDGIYRLS 57
Query: 410 GVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDA 469
GV+SNIQ+LR EF+SE PDL ++ Y+QDIH V SLCK YFRELP+PLLTY+LY+KF++A
Sbjct: 58 GVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEA 117
Query: 470 VSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 529
V + ERL+KI +V+++LP P+YRTLEFLMRHL +A + + TNMHA+NLAIVWAPNL
Sbjct: 118 VGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNL 177
Query: 530 LRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLL 589
LRSK IE++ F+GTAAFMEVR+QS+VVEFIL HVD LF G A S +S
Sbjct: 178 LRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGG--------AALSGGEVESGW 229
Query: 590 VSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQ 649
S P T+ E + P + ++ G+GP ++ +HTIIE +++
Sbjct: 230 RSLPGTRASGSPEDLMPRPLPYHLPSI-----LQAGDGPPQMR-PYHTIIEIAEHKRKGS 283
Query: 650 NKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEES 709
K++K WRS FNLG+S +KRKL R +E E K+ +GTLR AKS +S
Sbjct: 284 LKVRK-----WRSIFNLGRSGHETKRKLPRG-AEDREDKS-------NKGTLRPAKSMDS 330
Query: 710 LT-SLHAVDGDSKLFRPRRPRSS 731
L+ + A D L P PR S
Sbjct: 331 LSAAAGASDEPEGLVGPSSPRPS 353
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 132 bits (331), Expect = 5e-30
Identities = 75/223 (33%), Positives = 123/223 (55%), Gaps = 8/223 (3%)
Query: 346 LRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDG 404
LR F++ RPT Q L+++G +K++VFGC L VP+ +Q C +E G+ +DG
Sbjct: 303 LRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDG 362
Query: 405 IYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 464
+YR+SG + IQ+LR++ D + DL + +D+H + KL+FRELP PL + +
Sbjct: 363 LYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFR 421
Query: 465 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIV 524
+F A+ R + D+++ LP P++ TL L +HL + ++ M +++AIV
Sbjct: 422 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 481
Query: 525 WAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 567
+ P LLR + E T+ M + Q+ VVE IL +F
Sbjct: 482 FGPTLLRPEVEE------TSMPMTMVFQNQVVELILQQCADIF 518
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 132 bits (331), Expect = 5e-30
Identities = 75/223 (33%), Positives = 123/223 (55%), Gaps = 8/223 (3%)
Query: 346 LRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDG 404
LR F++ RPT Q L+++G +K++VFGC L VP+ +Q C +E G+ +DG
Sbjct: 330 LRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDG 389
Query: 405 IYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 464
+YR+SG + IQ+LR++ D + DL + +D+H + KL+FRELP PL + +
Sbjct: 390 LYRISGNLATIQKLRYKVDHDERLDLDDGRW-EDVHVITGALKLFFRELPEPLFPFSHFR 448
Query: 465 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIV 524
+F A+ R + D+++ LP P++ TL L +HL + ++ M +++AIV
Sbjct: 449 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 508
Query: 525 WAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 567
+ P LLR + E T+ M + Q+ VVE IL +F
Sbjct: 509 FGPTLLRPEVEE------TSMPMTMVFQNQVVELILQQCADIF 545
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 122 bits (307), Expect = 3e-27
Identities = 71/223 (31%), Positives = 124/223 (55%), Gaps = 8/223 (3%)
Query: 346 LRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDG 404
L+ F+ RP+ + L+++G++K+++FG L + VP ++ C +E+ G+ VDG
Sbjct: 255 LKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDG 314
Query: 405 IYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 464
IYR+SG + IQ+LR + E +L + +DIH V K++FRELP PL Y +E
Sbjct: 315 IYRVSGNLATIQKLRFIVNQEEKLNLDDSQW-EDIHVVTGALKMFFRELPEPLFPYSFFE 373
Query: 465 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIV 524
+F +A+ + R+ + ++Q+LPPP+ T++ L HL+ + S M ++L IV
Sbjct: 374 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV 433
Query: 525 WAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 567
+ P LLR++ +G A V Q+ + E +L+ +F
Sbjct: 434 FGPTLLRAEN-----ETGNMAIHMV-YQNQIAELMLSEYSKIF 470
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 122 bits (306), Expect = 4e-27
Identities = 78/249 (31%), Positives = 135/249 (54%), Gaps = 10/249 (4%)
Query: 321 QKVPQSVTN-SVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLL 379
QK P+ + + V S + K L+ F+ RPT Q ++++G +K++VFG +L
Sbjct: 604 QKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQ 663
Query: 380 NSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQD 438
VP+ ++ C +E +G+ +DGIYR+SG + IQ+LR + + DL + +D
Sbjct: 664 RENGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKW-ED 722
Query: 439 IHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLE 498
IH + K++FRELP PL T+ + F +A+ +R+ + D+I+QLP P+ T++
Sbjct: 723 IHVITGALKMFFRELPEPLFTFNHFNDFVNAIK-QEPRQRVAAVKDLIRQLPKPNQDTMQ 781
Query: 499 FLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEF 558
L RHL + + M +++AIV+ P LL+ ++ +G A V Q+ +VE
Sbjct: 782 ILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEK-----ETGNIAVHTV-YQNQIVEL 835
Query: 559 ILNHVDVLF 567
IL + +F
Sbjct: 836 ILLELSSIF 844
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 121 bits (304), Expect = 6e-27
Identities = 69/203 (33%), Positives = 117/203 (57%), Gaps = 8/203 (3%)
Query: 367 ERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSE 425
++V+ CDL + + P V+ C IE G+ +G+YR+SG + I+ ++ FD +
Sbjct: 263 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 322
Query: 426 -HVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHD 484
D++ Y +DI+ + KLYFR+LP PL+TY Y KF ++ +E+L +H+
Sbjct: 323 GEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHE 381
Query: 485 VIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTA 544
++ LPP H TL +LM HL + + M+A+NL IV+ P L+RS ++++ A
Sbjct: 382 ALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDA-----MA 436
Query: 545 AFMEVRIQSVVVEFILNHVDVLF 567
A ++R Q +VVE ++ + D+LF
Sbjct: 437 ALNDIRYQRLVVELLIKNEDILF 459
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 121 bits (304), Expect = 6e-27
Identities = 69/203 (33%), Positives = 117/203 (57%), Gaps = 8/203 (3%)
Query: 367 ERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSE 425
++V+ CDL + + P V+ C IE G+ +G+YR+SG + I+ ++ FD +
Sbjct: 237 KKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRD 296
Query: 426 -HVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHD 484
D++ Y +DI+ + KLYFR+LP PL+TY Y KF ++ +E+L +H+
Sbjct: 297 GEKADISVNMY-EDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHE 355
Query: 485 VIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTA 544
++ LPP H TL +LM HL + + M+A+NL IV+ P L+RS ++++ A
Sbjct: 356 ALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDA-----MA 410
Query: 545 AFMEVRIQSVVVEFILNHVDVLF 567
A ++R Q +VVE ++ + D+LF
Sbjct: 411 ALNDIRYQRLVVELLIKNEDILF 433
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 120 bits (300), Expect = 2e-26
Identities = 70/203 (34%), Positives = 112/203 (55%), Gaps = 8/203 (3%)
Query: 367 ERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIV-DGIYRLSGVASNIQRLRHEFDSE 425
++V+ CDL + + P V+ C IE G+ +G+YR+SG +I+ ++ FD +
Sbjct: 272 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 331
Query: 426 -HVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHD 484
D++ Y DI+ + KLYFR+LP P++TY Y KF DA + +ERL +H+
Sbjct: 332 GEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE 390
Query: 485 VIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTA 544
V+ LPP HY TL +LM HL + M+A+NL IV+ P L+R + S
Sbjct: 391 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPE-----DSTLT 445
Query: 545 AFMEVRIQSVVVEFILNHVDVLF 567
++R Q ++V+ ++ + DVLF
Sbjct: 446 TLHDMRYQKLIVQILIENEDVLF 468
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 120 bits (300), Expect = 2e-26
Identities = 70/203 (34%), Positives = 112/203 (55%), Gaps = 8/203 (3%)
Query: 367 ERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIV-DGIYRLSGVASNIQRLRHEFDSE 425
++V+ CDL + + P V+ C IE G+ +G+YR+SG +I+ ++ FD +
Sbjct: 136 KKVYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRD 195
Query: 426 -HVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHD 484
D++ Y DI+ + KLYFR+LP P++TY Y KF DA + +ERL +H+
Sbjct: 196 GEKADISANVY-PDINIITGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHE 254
Query: 485 VIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTA 544
V+ LPP HY TL +LM HL + M+A+NL IV+ P L+R + S
Sbjct: 255 VLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMRPPE-----DSTLT 309
Query: 545 AFMEVRIQSVVVEFILNHVDVLF 567
++R Q ++V+ ++ + DVLF
Sbjct: 310 TLHDMRYQKLIVQILIENEDVLF 332
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 115 bits (288), Expect = 4e-25
Identities = 72/225 (32%), Positives = 113/225 (50%), Gaps = 20/225 (8%)
Query: 329 NSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQV 388
+S+ P + ++ L+ + RP Q L++RG+L+++VFGC L G VP
Sbjct: 480 SSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSF 539
Query: 389 LQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVP------------------D 429
L+ C A +++ G+ VDGIYR+SG + +Q+LR D E D
Sbjct: 540 LRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLD 599
Query: 430 LTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQL 489
L + DIH V KL+ RELP PL+ L F A++ + E+ L +I ++I +
Sbjct: 600 LDSTEW-DDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSM 658
Query: 490 PPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQ 534
P P++ TL +L+ HL + + M NL IV+ P L R +Q
Sbjct: 659 PKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQ 703
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 115 bits (288), Expect = 4e-25
Identities = 72/225 (32%), Positives = 113/225 (50%), Gaps = 20/225 (8%)
Query: 329 NSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQV 388
+S+ P + ++ L+ + RP Q L++RG+L+++VFGC L G VP
Sbjct: 296 SSIRGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSF 355
Query: 389 LQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVP------------------D 429
L+ C A +++ G+ VDGIYR+SG + +Q+LR D E D
Sbjct: 356 LRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLD 415
Query: 430 LTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQL 489
L + DIH V KL+ RELP PL+ L F A++ + E+ L +I ++I +
Sbjct: 416 LDSTEW-DDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSM 474
Query: 490 PPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQ 534
P P++ TL +L+ HL + + M NL IV+ P L R +Q
Sbjct: 475 PKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQ 519
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 111 bits (278), Expect = 6e-24
Identities = 83/256 (32%), Positives = 132/256 (51%), Gaps = 20/256 (7%)
Query: 324 PQSV-TNSVPKPVSKKHGKLITFLRTF------MKSRPTKQKLKQRGILKERVFGCDLGE 376
PQ+V T + V + +G + F F +K P+K KQ G VFG +
Sbjct: 554 PQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSK---KQTG-----VFGVKISV 605
Query: 377 HLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEPY 435
+VP +++ C +E+ GI + GIYR+SGVA++IQ L+ FD+ + D+
Sbjct: 606 VTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANN-KDILLMLS 664
Query: 436 VQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYR 495
DI+++ KLYFRELP PLLT +LY F + ++ + + + +++ LP P+
Sbjct: 665 DMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLI 724
Query: 496 TLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFM---EVRIQ 552
T FL+ HL +A+ I M NLA V+ P LLR ++ES +AA + +V Q
Sbjct: 725 TFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQ 784
Query: 553 SVVVEFILNHVDVLFS 568
V+ + L H + F+
Sbjct: 785 VQVLLYYLQHPPISFA 800
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 111 bits (278), Expect = 6e-24
Identities = 83/256 (32%), Positives = 132/256 (51%), Gaps = 20/256 (7%)
Query: 324 PQSV-TNSVPKPVSKKHGKLITFLRTF------MKSRPTKQKLKQRGILKERVFGCDLGE 376
PQ+V T + V + +G + F F +K P+K KQ G VFG +
Sbjct: 600 PQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSK---KQTG-----VFGVKISV 651
Query: 377 HLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEPY 435
+VP +++ C +E+ GI + GIYR+SGVA++IQ L+ FD+ + D+
Sbjct: 652 VTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANN-KDILLMLS 710
Query: 436 VQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYR 495
DI+++ KLYFRELP PLLT +LY F + ++ + + + +++ LP P+
Sbjct: 711 DMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLI 770
Query: 496 TLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFM---EVRIQ 552
T FL+ HL +A+ I M NLA V+ P LLR ++ES +AA + +V Q
Sbjct: 771 TFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQ 830
Query: 553 SVVVEFILNHVDVLFS 568
V+ + L H + F+
Sbjct: 831 VQVLLYYLQHPPISFA 846
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 111 bits (278), Expect = 6e-24
Identities = 83/256 (32%), Positives = 132/256 (51%), Gaps = 20/256 (7%)
Query: 324 PQSV-TNSVPKPVSKKHGKLITFLRTF------MKSRPTKQKLKQRGILKERVFGCDLGE 376
PQ+V T + V + +G + F F +K P+K KQ G VFG +
Sbjct: 563 PQTVETKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSK---KQTG-----VFGVKISV 614
Query: 377 HLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEPY 435
+VP +++ C +E+ GI + GIYR+SGVA++IQ L+ FD+ + D+
Sbjct: 615 VTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANN-KDILLMLS 673
Query: 436 VQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYR 495
DI+++ KLYFRELP PLLT +LY F + ++ + + + +++ LP P+
Sbjct: 674 DMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLI 733
Query: 496 TLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFM---EVRIQ 552
T FL+ HL +A+ I M NLA V+ P LLR ++ES +AA + +V Q
Sbjct: 734 TFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVMAQ 793
Query: 553 SVVVEFILNHVDVLFS 568
V+ + L H + F+
Sbjct: 794 VQVLLYYLQHPPISFA 809
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 108 bits (269), Expect = 7e-23
Identities = 65/221 (29%), Positives = 112/221 (50%), Gaps = 11/221 (4%)
Query: 370 FGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFD--SEH 426
FG L EHL SG E+ +++C + G+ + G++R+ AS +++L+ D + H
Sbjct: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
Query: 427 VPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVI 486
+ + +P H+V K Y RELP PL+T+ LYE+++ S +++L +
Sbjct: 310 LDEFYSDP-----HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTC 364
Query: 487 QQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAF 546
Q+LPP ++ +L++ L+ LA + M N+AIV PNLL ++ + AA
Sbjct: 365 QKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAR--NEGTLAEMAAA 422
Query: 547 MEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKS 587
V + + V+E I+ H D F + + E L+ P S
Sbjct: 423 TSVHVVA-VIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSS 462
Score = 41.2 bits (95), Expect = 0.011
Identities = 82/331 (24%), Positives = 113/331 (34%), Gaps = 53/331 (16%)
Query: 1032 PPPPPKNVARMLALALAESAQQASTQSLKRPGT--SQAGYTNYG----DIAVATTEDNLS 1085
PP PP + + ++ Q + +S GT S AG G D + +D +S
Sbjct: 525 PPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVS 584
Query: 1086 SSYSAVALDKAYF-----QTDRPAEQFHLQNNAPGNCDHPLPETTATG------DPTHSN 1134
++ A + + Q A L P N P P T P
Sbjct: 585 AAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPG 644
Query: 1135 TTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPT 1194
G Q +G H LS P R S P H P G+ S P+
Sbjct: 645 NPPPGHPGGQSS-SGTSQHPPSLSPKPP-TRSPSPPTQ------HTGQPP---GQPSAPS 693
Query: 1195 VSFLDQDQSPPRFYSG--------DQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDK-I 1245
S PR YS + PP L H + P P LPS+ +
Sbjct: 694 ------QLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGL 747
Query: 1246 YPPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAE-QPTTADFAAATLQRTHRTNR 1304
PS +P + T T +T P Q + A +A P TA A TL R R
Sbjct: 748 EQPSHTPPQ-----TPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRP----R 798
Query: 1305 PLPPPPSQRSAEQPPVVGQVQAATNIGLNNS 1335
P+P P ++ S PP V +A + L N+
Sbjct: 799 PVPKPRNRPSVPPPPQPPGVHSAGDSSLTNT 829
Score = 33.9 bits (76), Expect = 1.7
Identities = 57/262 (21%), Positives = 87/262 (33%), Gaps = 43/262 (16%)
Query: 1110 QNNAPGNCDHPLPETTATGDPTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSV 1169
Q +PG+ P P+ DP + G + Q+ NQP A S +
Sbjct: 567 QGPSPGDGSPPKPK-----DPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQ---- 617
Query: 1170 PLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLG--ASVDKLHHP 1227
P + +G S T+ + +P G+ PP + G +S HP
Sbjct: 618 -------------PHNAAGP-SPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHP 663
Query: 1228 LEFADKSPT-PPNLPSDKIYPPSGSPEENTS-TATMTYMTT---------------TPAT 1270
+ K PT P+ P+ P G P + +A Y ++ T AT
Sbjct: 664 PSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQAT 723
Query: 1271 AQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVVGQVQAATNI 1330
M TK S P Q +H + PP + +Q P + Q
Sbjct: 724 PLMHTKPNSQG-PPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGG 782
Query: 1331 GLNNSHKVQGVVPVPERPPEPR 1352
+ G +P P P+PR
Sbjct: 783 NPETAQPHAGTLPRPRPVPKPR 804
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 108 bits (269), Expect = 7e-23
Identities = 65/221 (29%), Positives = 112/221 (50%), Gaps = 11/221 (4%)
Query: 370 FGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFD--SEH 426
FG L EHL SG E+ +++C + G+ + G++R+ AS +++L+ D + H
Sbjct: 250 FGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSH 309
Query: 427 VPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVI 486
+ + +P H+V K Y RELP PL+T+ LYE+++ S +++L +
Sbjct: 310 LDEFYSDP-----HAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTC 364
Query: 487 QQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAF 546
Q+LPP ++ +L++ L+ LA + M N+AIV PNLL ++ + AA
Sbjct: 365 QKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAR--NEGTLAEMAAA 422
Query: 547 MEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKS 587
V + + V+E I+ H D F + + E L+ P S
Sbjct: 423 TSVHVVA-VIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSS 462
Score = 38.5 bits (88), Expect = 0.070
Identities = 55/219 (25%), Positives = 80/219 (36%), Gaps = 30/219 (13%)
Query: 1120 PLPETTATGDPTH-SNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDD 1178
P P P H + SG H L+ P ++ + T P +
Sbjct: 560 PAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRS----PSPPTQHTGQPPGQPSAPS 615
Query: 1179 HVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPP 1238
+S P S ++S + PP QPP+ L H + P P
Sbjct: 616 QLSAPRRYSS-----SLSPIQAPNHPP-----PQPPT----QATPLMHTKPNSQGPPNPM 661
Query: 1239 NLPSDK-IYPPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAE-QPTTADFAAATL 1296
LPS+ + PS +P + T T +T P Q + A +A P TA A TL
Sbjct: 662 ALPSEHGLEQPSHTPPQ-----TPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTL 716
Query: 1297 QRTHRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNS 1335
R RP+P P ++ S PP V +A + L N+
Sbjct: 717 PRP----RPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNT 751
Score = 33.9 bits (76), Expect = 1.7
Identities = 61/293 (20%), Positives = 96/293 (32%), Gaps = 43/293 (14%)
Query: 1079 TTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTES 1138
TT + S ++ D + RPA ++ + P P+ DP +
Sbjct: 458 TTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESPPKPK-----DPVSAAVPAP 512
Query: 1139 GEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFL 1198
G + Q+ NQP A S + P + +G S T+
Sbjct: 513 GRNNSQIASGQNQPQAAAGSHQLSMGQ-----------------PHNAAGP-SPHTLRRA 554
Query: 1199 DQDQSPPRFYSGDQPPSYLG--ASVDKLHHPLEFADKSPT-PPNLPSDKIYPPSGSPEEN 1255
+ +P G+ PP + G +S HP + K PT P+ P+ P G P
Sbjct: 555 VKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAP 614
Query: 1256 TS-TATMTYMTT---------------TPATAQMSTKEASWDVAEQPTTADFAAATLQRT 1299
+ +A Y ++ T AT M TK S P Q +
Sbjct: 615 SQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQG-PPNPMALPSEHGLEQPS 673
Query: 1300 HRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPR 1352
H + PP + +Q P + Q + G +P P P+PR
Sbjct: 674 HTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPR 726
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 104 bits (259), Expect = 1e-21
Identities = 80/291 (27%), Positives = 146/291 (50%), Gaps = 20/291 (6%)
Query: 339 HGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIER 398
H K +T L+ + + K +Q +++ FG L EHL SG E+ +++C +
Sbjct: 226 HRKSLTLLQAVLP----QIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLE 281
Query: 399 YGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPL 457
G+ + G++R++ AS +++L+ D V D+ + Y D H++ K Y RELP PL
Sbjct: 282 CGMQEEGLFRVAPSASKLKKLKAALDC-CVVDV--QEYSADPHAIAGALKSYLRELPEPL 338
Query: 458 LTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMH 517
+T++LY+++ A + +++L + + ++LP ++ + +L++ LS L++Y + M
Sbjct: 339 MTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMT 398
Query: 518 AKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSV-VVEFILNHVDVLFSGRI--SMA 574
N+AIV PNLL + A + T V +Q V ++E I+ H D F G I ++
Sbjct: 399 PSNMAIVLGPNLLWPQ----AEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNIT 454
Query: 575 MQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVNSP--IVTENKYIE 623
G+ + S PS ++ A R Q P + T+N +E
Sbjct: 455 GNYGSPVHVNHNANYSSMPSP---DMDPADRRQPEQARRPLSVATDNMMLE 502
>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
Length = 701
Score = 103 bits (258), Expect = 1e-21
Identities = 70/207 (33%), Positives = 107/207 (51%), Gaps = 6/207 (2%)
Query: 368 RVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEH 426
RV+G L HL G E+ +++C + G+ + G++RL+ AS ++RL+ S+
Sbjct: 272 RVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASD- 330
Query: 427 VPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVI 486
+ E + D H+V K Y RELP PL+T+ LY+ + A S RL + +V
Sbjct: 331 --PHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVC 388
Query: 487 QQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAF 546
+LPP + L +LM+ L+ LA+ + M N+AIV PNLL + E AA
Sbjct: 389 SRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAAS 448
Query: 547 MEVRIQSV-VVEFILNHVDVLFSGRIS 572
+ IQ V VVE ++ D LF G I+
Sbjct: 449 VS-SIQVVGVVEALIQSADTLFPGDIN 474
Score = 36.6 bits (83), Expect = 0.26
Identities = 49/207 (23%), Positives = 76/207 (36%), Gaps = 31/207 (14%)
Query: 1235 PTPPNLPSDKIYPPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAEQPTTADFAAA 1294
PTP P+ P+ +P + A + T +++ + AS V P + AA
Sbjct: 505 PTPATTPA-----PAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPP--ETAAP 557
Query: 1295 TLQRTHRTNRP------LPPPPSQRSAEQPPV---------VGQVQAATNIGLNNSHKVQ 1339
RT RP +PPP S PP G QA + +S +
Sbjct: 558 VEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAP 617
Query: 1340 GV-VPVPERPPEP---RAMDDPASAFISDSG-AAAAQCPMATAVQPGLPEKVRDGARVPL 1394
V P+P PP+P ++ PAS + G A+ + ++ Q L +G
Sbjct: 618 TVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNPAQVDLGAATAEGGAPEA 677
Query: 1395 LHLRAESVPAHPCGFPAPLPPTRMMES 1421
+ VP P P P P + E+
Sbjct: 678 I----SGVPTPPAIPPQPRPRSLASET 700
Score = 35.0 bits (79), Expect = 0.77
Identities = 45/173 (26%), Positives = 61/173 (35%), Gaps = 25/173 (14%)
Query: 1427 IHSSSADATSSSNYHSFVTASSTSVDDALPLPLPVPQPKHASQKT-------VYSSFARP 1479
+ + +D +S S + + P P P P P AS T V A P
Sbjct: 486 LQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASP 545
Query: 1480 DVTTEPFGPDNCLHFNMTPNCQYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVA 1539
VT P P+ RP P + QV G+RS PPA +
Sbjct: 546 KVTRSP--PETAAPVEDMARRTKRPAPARP---TMPPPQVSGSRSSPPAPP-------LP 593
Query: 1540 PGRNASGHHSKPCSRVEYVSSLSSSVRNTCYPEDIPPY-PTIRRVQSLHAPPS 1591
PG + G R+ + SS+R P +PP P R QS +P S
Sbjct: 594 PGSGSPGTPQALPRRL-----VGSSLRAPTVPPPLPPTPPQPARRQSRRSPAS 641
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 101 bits (252), Expect = 7e-21
Identities = 87/333 (26%), Positives = 144/333 (43%), Gaps = 31/333 (9%)
Query: 388 VLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRH-----EFDSEHVPDLTKEPYVQDIHS 441
+++ C +E GI + G+YR+ GV S +Q+L + SE D+ E +I +
Sbjct: 392 IIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAE---WEIKT 448
Query: 442 VGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLM 501
+ S K Y R LP PL+ YQ F A E R+ +IH ++ +LP + + L+ LM
Sbjct: 449 ITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLM 508
Query: 502 RHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILN 561
HL+ +A+ M NL +V+ P LLR ++ AA M+++ Q++V+E ++
Sbjct: 509 NHLANVANNHKQNLMTVANLGVVFGPTLLRPQE------ETVAAIMDIKFQNIVIEILIE 562
Query: 562 HVDVLFSGRISMAMQEGAASLSRPKSLLVSSP--STKLLTLEEAQARTQAQVNSPIVTEN 619
+ + +F+ M + LSR KS P S + LTL T+ Q + +
Sbjct: 563 NHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSIINS 622
Query: 620 KYIEVGEGP-------AALQGKFHT------IIEFPLERKRPQNKMKKSPVG-SWRSFFN 665
V P ++LQ ++ +++ P N SP+ SW F
Sbjct: 623 SLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSA 682
Query: 666 LGKSSSVSKRKLQRNESEPSEMKAMALKGGRAE 698
S + KA AL +AE
Sbjct: 683 PSSPMPTSSTSSDSSPVSTPFRKAKALYACKAE 715
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 101 bits (252), Expect = 7e-21
Identities = 91/351 (25%), Positives = 157/351 (44%), Gaps = 39/351 (11%)
Query: 388 VLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRH-----EFDSEHVPDLTKEPYVQDIHS 441
+++ C +E GI + G+YR+ GV S +Q+L + SE D+ E +I +
Sbjct: 392 IIRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAE---WEIKT 448
Query: 442 VGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLM 501
+ S K Y R LP PL+ YQ F A E R+ +IH ++ +LP + + L+ LM
Sbjct: 449 ITSALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLM 508
Query: 502 RHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILN 561
HL+ +A+ M NL +V+ P LLR ++ AA M+++ Q++V+E ++
Sbjct: 509 NHLANVANNHKQNLMTVANLGVVFGPTLLRPQE------ETVAAIMDIKFQNIVIEILIE 562
Query: 562 HVDVLFSGRISMAMQEGAASLSRPKSLLVSSP--STKLLTLEEAQARTQAQVNSPIVTEN 619
+ + +F+ M + LSR KS P S + LTL T+ Q + +
Sbjct: 563 NHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSIINS 622
Query: 620 KYIEVGEGP-------AALQGKFHT------IIEFPLERKRPQNKMKKSPVG-SWRSFFN 665
V P ++LQ ++ +++ P N SP+ SW F
Sbjct: 623 SLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMF-- 680
Query: 666 LGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAV 716
S+ S S+ S ++++A G ++ + + +SLHAV
Sbjct: 681 ---SAPSSPMPTSSTSSDSSPVRSVA---GFVWFSVAAVVLSLARSSLHAV 725
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 97.4 bits (241), Expect = 1e-19
Identities = 57/170 (33%), Positives = 94/170 (55%), Gaps = 2/170 (1%)
Query: 369 VFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHV 427
VFG + +VP +++ C IER G+ + GIYR+SGVA++IQ L+ FD +
Sbjct: 1007 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN- 1065
Query: 428 PDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQ 487
D++ D++++ KLYFRELP PL T + Y F++ ++ + + + +++
Sbjct: 1066 KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1125
Query: 488 QLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIES 537
LP + T FL+ HL +A+ ++ M NLA V+ P LLR + ES
Sbjct: 1126 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1175
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 97.4 bits (241), Expect = 1e-19
Identities = 57/170 (33%), Positives = 94/170 (55%), Gaps = 2/170 (1%)
Query: 369 VFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHV 427
VFG + +VP +++ C IER G+ + GIYR+SGVA++IQ L+ FD +
Sbjct: 1051 VFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNN- 1109
Query: 428 PDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQ 487
D++ D++++ KLYFRELP PL T + Y F++ ++ + + + +++
Sbjct: 1110 KDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLL 1169
Query: 488 QLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIES 537
LP + T FL+ HL +A+ ++ M NLA V+ P LLR + ES
Sbjct: 1170 SLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKES 1219
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 96.7 bits (239), Expect = 2e-19
Identities = 62/168 (36%), Positives = 94/168 (55%), Gaps = 5/168 (2%)
Query: 365 LKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFD 423
L R FG +L L + VP V++ +IE +G+ +GIYR SG + I+ LR D
Sbjct: 2056 LSSRQFGVELSR-LTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLD 2114
Query: 424 SEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIH 483
++ + + Y +IH + S+ K + R+LPNPL+T++LYE+F A+ +E + ++
Sbjct: 2115 TD-AESVNLDDY--NIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVY 2171
Query: 484 DVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLR 531
VI QL H TLE L+ HL +A M A LAIV+AP +LR
Sbjct: 2172 SVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILR 2219
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 95.1 bits (235), Expect = 6e-19
Identities = 67/251 (26%), Positives = 122/251 (48%), Gaps = 36/251 (14%)
Query: 388 VLQSCTAFIERYGIVD-GIYRLSGVASNIQRLR---------HEFDSEHVPDLTKEPYVQ 437
+++ C + +E GI D G+YR+ GV+S +QRL +E D E+ D
Sbjct: 398 IIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADW------- 450
Query: 438 DIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTL 497
++ ++ S K Y R LP PL+TY+L+ F + + E R+ IH ++ +LP + L
Sbjct: 451 EVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEML 510
Query: 498 EFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVE 557
+ L++HL+ ++++ M NL +V+ P L+R ++ AA M+++ Q++VVE
Sbjct: 511 DILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQE------ETVAALMDLKFQNIVVE 564
Query: 558 FILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQ-VNSPIV 616
++ + + +F E P L S P+ Q++ Q Q P+
Sbjct: 565 ILIENHEKIFRTPPDTTFPE-------PTCLSASPPNA-----PPRQSKRQGQRTKRPVA 612
Query: 617 TENKYIEVGEG 627
N +E+ +G
Sbjct: 613 VYNLCLELEDG 623
>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
sapiens]
Length = 653
Score = 94.7 bits (234), Expect = 8e-19
Identities = 94/393 (23%), Positives = 161/393 (40%), Gaps = 34/393 (8%)
Query: 386 PQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGS 444
P +++ C FI + G+ + G++RL G A+ ++ L+ FD P D+H+V S
Sbjct: 58 PMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNT---DVHTVAS 114
Query: 445 LCKLYFRELPNPLLTYQLYEKFSDAVSAATDEER--LIKIHDVIQQLPPPHYRTLEFLMR 502
L KLY RELP P++ Y YE F + EE + ++ ++ LP +Y L+++ R
Sbjct: 115 LLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICR 174
Query: 503 HLSLLADYCSITNMHAKNLAIVWAPNLLRSK-QIESACFSGTAAFMEVRIQSVVVEFILN 561
L + Y + M +NLA V+ PN+LR K + GT V +Q ++ I
Sbjct: 175 FLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGT-----VVVQQLMSVMISK 229
Query: 562 HVDVLF--SGRISMAMQEGAASLSR-PKSLLVSSPSTKLLTLEEAQARTQAQVNSPIVTE 618
H D LF + Q+G ++ + K + K + Q + +
Sbjct: 230 H-DCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQ 288
Query: 619 NKYIEVGEGPAALQGK-----FHTIIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVS 673
+ G P AL G +++ + + R P K G SS +
Sbjct: 289 RSSMNNG-SPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSN 347
Query: 674 KRKLQRNESEPS-EMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSS 732
L++ ++ P+ ++A + GT S ++ T + L P R+ S
Sbjct: 348 AEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMS 407
Query: 733 ----------DALSASFNGEM-LGNRCNSYDNL 754
D GE+ NR ++YDN+
Sbjct: 408 WLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNV 440
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.128 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,522,083
Number of Sequences: 37866
Number of extensions: 4960350
Number of successful extensions: 21319
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 558
Number of HSP's that attempted gapping in prelim test: 17625
Number of HSP's gapped (non-prelim): 3735
length of query: 2087
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1969
effective length of database: 13,779,330
effective search space: 27131500770
effective search space used: 27131500770
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.