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Search of human proteins with 216548223
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]
(742 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens] 1511 0.0
gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens] 941 0.0
gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens] 895 0.0
gi|24308167 SV2 related protein [Homo sapiens] 125 1e-28
gi|213021148 SVOP-like isoform 1 [Homo sapiens] 108 1e-23
gi|4507005 solute carrier family 22 member 5 [Homo sapiens] 81 3e-15
gi|166064021 solute carrier family 22 (organic anion transporter... 75 3e-13
gi|90669191 solute carrier family 22 member 7 isoform b [Homo sa... 73 1e-12
gi|24497497 solute carrier family 22 member 7 isoform a [Homo sa... 73 1e-12
gi|157426885 organic cation transporter like 4 [Homo sapiens] 68 3e-11
gi|4507001 solute carrier family 22 member 2 [Homo sapiens] 67 5e-11
gi|23510410 solute carrier family 22 member 1 isoform b [Homo sa... 66 1e-10
gi|4506999 solute carrier family 22 member 1 isoform a [Homo sap... 66 1e-10
gi|166197673 solute carrier family 22, member 15 [Homo sapiens] 65 2e-10
gi|24497490 solute carrier family 22 member 4 [Homo sapiens] 63 9e-10
gi|11415038 solute carrier family 22 member 3 [Homo sapiens] 61 4e-09
gi|24497480 solute carrier family 22 member 6 isoform d [Homo sa... 59 2e-08
gi|24497478 solute carrier family 22 member 6 isoform c [Homo sa... 59 2e-08
gi|24497476 solute carrier family 22 member 6 isoform b [Homo sa... 59 2e-08
gi|20070188 solute carrier family 22 member 6 isoform a [Homo sa... 59 2e-08
gi|24497499 solute carrier family 22 member 8 [Homo sapiens] 58 4e-08
gi|31542327 solute carrier family 22, member 16 [Homo sapiens] 56 1e-07
gi|33457322 SVOP-like isoform 2 [Homo sapiens] 56 1e-07
gi|21361449 solute carrier family 2 (facilitated glucose transpo... 54 5e-07
gi|8923870 solute carrier family 22 member 11 [Homo sapiens] 54 7e-07
gi|238814326 solute carrier family 22, member 20 [Homo sapiens] 53 1e-06
gi|190684655 glucose transporter protein 10 isoform a [Homo sapi... 52 2e-06
gi|68226420 glucose transporter protein 10 isoform c [Homo sapiens] 52 2e-06
gi|68226418 glucose transporter protein 10 isoform b [Homo sapiens] 52 2e-06
gi|215490102 spinster homolog 1 isoform 3 [Homo sapiens] 50 1e-05
>gi|216548223 synaptic vesicle glycoprotein 2 [Homo sapiens]
Length = 742
Score = 1511 bits (3911), Expect = 0.0
Identities = 742/742 (100%), Positives = 742/742 (100%)
Query: 1 MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA 60
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA
Sbjct: 1 MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA 60
Query: 61 PSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA 120
PSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA
Sbjct: 61 PSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA 120
Query: 121 GVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG 180
GVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG
Sbjct: 121 GVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG 180
Query: 181 VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS 240
VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS
Sbjct: 181 VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS 240
Query: 241 VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW 300
VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW
Sbjct: 241 VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW 300
Query: 301 MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF 360
MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF
Sbjct: 301 MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF 360
Query: 361 FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW 420
FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW
Sbjct: 361 FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW 420
Query: 421 GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY 480
GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY
Sbjct: 421 GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY 480
Query: 481 ASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT 540
ASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT
Sbjct: 481 ASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT 540
Query: 541 SSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFV 600
SSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFV
Sbjct: 541 SSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFV 600
Query: 601 SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG 660
SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG
Sbjct: 601 SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG 660
Query: 661 VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS 720
VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS
Sbjct: 661 VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS 720
Query: 721 AALALGSSLALKLPETRGQVLQ 742
AALALGSSLALKLPETRGQVLQ
Sbjct: 721 AALALGSSLALKLPETRGQVLQ 742
>gi|73695465 synaptic vesicle glycoprotein 2C [Homo sapiens]
Length = 727
Score = 941 bits (2431), Expect = 0.0
Identities = 467/741 (63%), Positives = 564/741 (76%), Gaps = 15/741 (2%)
Query: 1 MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPA 60
ME+ ++DR + ++GAKDIA+EVKK KKV + +DR QDEY++RSYSRF++E+DDDD+
Sbjct: 1 MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDY-Y 59
Query: 61 PSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLA 120
P+ Y GE DE SS+ATEGHDEDDEIYEGEYQGIP K ++ G P
Sbjct: 60 PAGETYNGEANDDE----GSSEATEGHDEDDEIYEGEYQGIPSMNQA-KDSIVSVGQP-- 112
Query: 121 GVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMADG 180
E E++RR + EELAQQYE I++ECGHGRFQW L+FVLG+ALMADG
Sbjct: 113 ------KGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADG 166
Query: 181 VEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLS 240
VEVFVVGFVLPSAE D+C+ +S G LG IVYLGMMVGAF WGGLAD++GR+Q LLI +S
Sbjct: 167 VEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMS 226
Query: 241 VNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFW 300
VN FAF SSFVQGYG FLFCRLLSG GIGG+IP VFSYF+E LA+EKRGEHLSWLCMFW
Sbjct: 227 VNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFW 286
Query: 301 MIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRF 360
MIGG+YA+AMAWAIIPHYGWSF MGSAYQFHSWRVFV+VCA P V ++ ALT PESPRF
Sbjct: 287 MIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRF 346
Query: 361 FLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRW 420
LE GKHDEAWM+LK +HDTNMRA+G PE+VF+V IKT Q DELIEI+SDTGTWY+R
Sbjct: 347 LLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRC 406
Query: 421 GVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDY 480
VR + +W F+ CF R T+ + VWFT+SF YYGL+VWFPD+I+ LQ+ +Y
Sbjct: 407 FVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEY 466
Query: 481 ASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVT 540
A T+ ++ + T NFT+ENQIH G +Y N +FIG++ KSV+F+DS+F+ C FEDVT
Sbjct: 467 ALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVT 526
Query: 541 SSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYFV 600
S NT+F+NCTFI+TVF NTD YKF++S N +F HNK GC + AY +YFV
Sbjct: 527 SVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQI-TFDDDYSAYWIYFV 585
Query: 601 SFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGG 660
+FLGTLAVLPGNIVSALLMD+IGRL ML GS V+S +SCFFL FG SES MI +LCL+ G
Sbjct: 586 NFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNG 645
Query: 661 VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFAS 720
++I++WN+LDV+TVELYP+D+R T FGFLNALCK AAVLG IF S V ITK+ PIL AS
Sbjct: 646 LTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLAS 705
Query: 721 AALALGSSLALKLPETRGQVL 741
L G + L LP+TR QVL
Sbjct: 706 TVLVCGGLVGLCLPDTRTQVL 726
>gi|7662270 synaptic vesicle protein 2B homolog [Homo sapiens]
Length = 683
Score = 895 bits (2314), Expect = 0.0
Identities = 438/682 (64%), Positives = 528/682 (77%), Gaps = 13/682 (1%)
Query: 60 APSDGYYRGEGTQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPL 119
APSDGYYRG + EE+ A SD TEGHDE+DEIYEGEYQGIP + + + +
Sbjct: 14 APSDGYYRGNESNPEED--AQSDVTEGHDEEDEIYEGEYQGIPHPDDVKAKQAKMAPSRM 71
Query: 120 AGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYFVLGLALMAD 179
+RG A+R ++ E+LA QYE I+ ECGHGRFQW L+FVLGLALMAD
Sbjct: 72 DSLRGQTDL---------MAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMAD 122
Query: 180 GVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISL 239
GVEVFVV F LPSAEKDMCLS S KGMLG+IVYLGMM GAF+ GGLAD+LGR++ L +SL
Sbjct: 123 GVEVFVVSFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSL 182
Query: 240 SVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMF 299
+VN+ FA SSFVQGYG FLFCRL+SG+GIGG++PIVF+YFSEFL++EKRGEHLSWL +F
Sbjct: 183 AVNASFASLSSFVQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIF 242
Query: 300 WMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPR 359
WM GG+YA+AMAW+IIPHYGW F MG+ Y FHSWRVFV+VCA P ++ AL PESPR
Sbjct: 243 WMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFMPESPR 302
Query: 360 FFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQR 419
F LE GKHDEAWM+LKQVHDTNMRAKG PE+VF+V++IKT Q DE IEIQS TGTWYQR
Sbjct: 303 FLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQR 362
Query: 420 WGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVD 479
W VR ++ QVW N L C YR TL++ VWF M+FSYYGLTVWFPDMIR+ Q +
Sbjct: 363 WLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEE 422
Query: 480 YASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDV 539
Y S+ KVF GE V T NFT+ENQIH+ G+ NDKF + K V FED+ F+ECYFEDV
Sbjct: 423 YKSKMKVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDV 482
Query: 540 TSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYMVYF 599
TS++T+F+NCT +T+FYNTDL+E+KF+N R INSTFL KEGC +D+ + +++Y
Sbjct: 483 TSTDTYFKNCTIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDND--FLIYL 540
Query: 600 VSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFG 659
VSFLG+L+VLPGNI+SALLMD+IGRL+M+ GS ++S V CFFL FGNSESAMI CLF
Sbjct: 541 VSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFC 600
Query: 660 GVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFA 719
G SIA+WNALDV+TVELYP+++R TAFG LN LCK A+LG +IF SFVGITK PIL A
Sbjct: 601 GTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLA 660
Query: 720 SAALALGSSLALKLPETRGQVL 741
+A+L G +AL+LPETR QVL
Sbjct: 661 AASLVGGGLIALRLPETREQVL 682
>gi|24308167 SV2 related protein [Homo sapiens]
Length = 548
Score = 125 bits (314), Expect = 1e-28
Identities = 89/333 (26%), Positives = 147/333 (44%), Gaps = 48/333 (14%)
Query: 153 EAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVY 212
E + G G+FQW L + GLA MAD +E+ ++ + P + L +L +V+
Sbjct: 71 EDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVF 130
Query: 213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGS 272
+GMM + LWG ++D+ GR+ L IS+ + S+F Y L R L G GIGG
Sbjct: 131 VGMMSSSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGG- 189
Query: 273 IPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHS 332
+P + ++EFL + R + + + +FW IG V+ +A ++P G
Sbjct: 190 VPQSVTLYAEFLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMPSLG------------- 236
Query: 333 WRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVF 392
WR +++ A P + PES R+ + +G ++A LK++ N G P
Sbjct: 237 WRWLLILSAVPLLLFAVLCFWLPESARYDVLSGNQEKAIATLKRIATEN----GAP---M 289
Query: 393 SVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMG 452
+ + QED G F P +R TL++
Sbjct: 290 PLGKLIISRQEDR---------------------------GKMRDLFTPHFRWTTLLLWF 322
Query: 453 VWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTK 485
+WF+ +FSYYGL + ++ + +SR K
Sbjct: 323 IWFSNAFSYYGLVLLTTELFQAGDVCGISSRKK 355
Score = 40.0 bits (92), Expect = 0.008
Identities = 33/144 (22%), Positives = 62/144 (43%), Gaps = 11/144 (7%)
Query: 605 TLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGVSIA 664
TL+ PG +V+ ++D++GR + +A V+ L + + LL +
Sbjct: 380 TLSEFPGVLVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISG 439
Query: 665 SWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALA 724
+ A V T E+YP+ R G + + ++ A++ T F+ ++ + A+
Sbjct: 440 GFQAAYVYTPEVYPTATRALGLGTCSGMARVGALI-----TPFIAQVMLESSVYLTLAVY 494
Query: 725 LGSSLALKLP------ETRGQVLQ 742
G L L ET+G+ LQ
Sbjct: 495 SGCCLLAALASCFLPIETKGRGLQ 518
>gi|213021148 SVOP-like isoform 1 [Homo sapiens]
Length = 492
Score = 108 bits (271), Expect = 1e-23
Identities = 83/313 (26%), Positives = 134/313 (42%), Gaps = 50/313 (15%)
Query: 153 EAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVY 212
E + G GRF L+ ++G + + +E+ ++ V P + L + ++ +V+
Sbjct: 35 EDAVETIGFGRFHIALFLIMGSTGVVEAMEIMLIAVVSPVIRCEWQLENWQVALVTTMVF 94
Query: 213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGG- 271
G MV + L+G LADR GR + LLIS + F+ +SF Y F+F R + G G+ G
Sbjct: 95 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH 154
Query: 272 SIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFH 331
S ++ +EFL + RG L +FW+ G + +A IIP G
Sbjct: 155 SQGLIIK--TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG------------ 200
Query: 332 SWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERV 391
WR + V + P + I A PES RF + G A L++V N
Sbjct: 201 -WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMN---------- 249
Query: 392 FSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMM 451
+++ E +L+E + G F +Y R TL +
Sbjct: 250 ------RSVMPEGKLVEPVLEKR------------------GRFADLLDAKYLRTTLQIW 285
Query: 452 GVWFTMSFSYYGL 464
+W +SF+YYG+
Sbjct: 286 VIWLGISFAYYGV 298
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/151 (25%), Positives = 70/151 (46%), Gaps = 8/151 (5%)
Query: 595 YMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFG--NSESAMI 652
Y +S +G +A+ P NI+ + R L+ S M C + FFL S + +I
Sbjct: 344 YRTMIISTIGEIALNPLNILGINFLG-----RRLSLSITMGCTALFFLLLNICTSSAGLI 398
Query: 653 ALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITK 712
L + + A++N + + T E+YP+ R G +LC++ A++ I + +
Sbjct: 399 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 458
Query: 713 AAPILFASAALALGSSLALKLP-ETRGQVLQ 742
+ S+ + + A LP ET+G+ LQ
Sbjct: 459 LGALCLFSSVCVVCAISAFTLPIETKGRALQ 489
>gi|4507005 solute carrier family 22 member 5 [Homo sapiens]
Length = 557
Score = 81.3 bits (199), Expect = 3e-15
Identities = 60/275 (21%), Positives = 120/275 (43%), Gaps = 41/275 (14%)
Query: 197 MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG 256
+C D + + ++G+++G+F+ G L+DR GR+ L +++ + + F+F F + +
Sbjct: 135 VCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFE 194
Query: 257 TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIP 316
F+ +L G+G + F +E L + R +F +G A + ++P
Sbjct: 195 MFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR-------IIFSTLGVCIFYAFGYMVLP 247
Query: 317 HYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQ 376
+ AY WR+ ++ P V + PESPR+ + G+ +EA +++++
Sbjct: 248 LF--------AYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK 299
Query: 377 VHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFL 436
N + TI EL ++ S Q + L + W
Sbjct: 300 AAKAN-----------GIVVPSTIFDPSELQDLSSKK---QQSHNILDLL---RTW---- 338
Query: 437 SCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDM 471
R +T+M + +W T+S Y+GL++ P++
Sbjct: 339 -----NIRMVTIMSIMLWMTISVGYFGLSLDTPNL 368
>gi|166064021 solute carrier family 22 (organic anion transporter),
member 13 [Homo sapiens]
Length = 551
Score = 74.7 bits (182), Expect = 3e-13
Identities = 68/285 (23%), Positives = 113/285 (39%), Gaps = 51/285 (17%)
Query: 190 LPSAEKD---MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFA 246
LPS + + +C K + G++VG ++G L DR+GR+ +L L + ++
Sbjct: 120 LPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIG 179
Query: 247 FFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVY 306
++FV + ++ R + G S+ + L E W+ W V
Sbjct: 180 LATAFVPSFELYMALRFAVATAVAG-----LSFSNVTLLTE-------WVGPSWRTQAVV 227
Query: 307 AAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGK 366
A +++ G G AY F +WR+ + P + PES R+ L G+
Sbjct: 228 LAQCNFSL----GQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESARWLLTRGR 283
Query: 367 HDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALS 426
DEA ++++ N R K PE + + KT
Sbjct: 284 MDEAIQLIQKAASVN-RRKLSPELMNQLVPEKTGPS------------------------ 318
Query: 427 LGGQVWGNFLSCF-GPEYRRITLMMMGVWFTMSFSYYGLTVWFPD 470
GN L F P+ R++TL++ VWF S YYGL++ D
Sbjct: 319 ------GNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGD 357
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/155 (23%), Positives = 68/155 (43%), Gaps = 5/155 (3%)
Query: 591 GEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSE-S 649
G+ VY + +P S +M + GR G+ V+ + C + F ++
Sbjct: 356 GDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLP 415
Query: 650 AMIALLCLFGGVSIASWNALD-VLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFV 708
++ +L + G ++ A+ + V + EL+P+ R T G + ++ +L + +
Sbjct: 416 VVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQTGMGLVGIFSRIGGIL--TPLVILL 473
Query: 709 GITKAA-PILFASAALALGSSLALKLPETRGQVLQ 742
G AA P+L + + L LPET GQ L+
Sbjct: 474 GEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLK 508
>gi|90669191 solute carrier family 22 member 7 isoform b [Homo
sapiens]
Length = 548
Score = 72.8 bits (177), Expect = 1e-12
Identities = 69/256 (26%), Positives = 100/256 (39%), Gaps = 42/256 (16%)
Query: 212 YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGG 271
+ G++VGA +G L+DR GRR+ LL++ V S+ Y F R L+G + G
Sbjct: 152 FAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAG 211
Query: 272 SIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFH 331
IV E+L E R FW GGV A+ Y
Sbjct: 212 FTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVMLLALV---------------GYLIR 255
Query: 332 SWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERV 391
WR +L P I +L PES R+ L G EA L +H + + E
Sbjct: 256 DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL--LHCARLNGRPVCEDS 313
Query: 392 FSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF-GPEYRRITLMM 450
FS + + + ++ S +L F P R I+L
Sbjct: 314 FSQEAVSKVAAGERVVRRPS-----------------------YLDLFRTPRLRHISLCC 350
Query: 451 MGVWFTMSFSYYGLTV 466
+ VWF ++FSYYGL++
Sbjct: 351 VVVWFGVNFSYYGLSL 366
>gi|24497497 solute carrier family 22 member 7 isoform a [Homo
sapiens]
Length = 546
Score = 72.8 bits (177), Expect = 1e-12
Identities = 69/256 (26%), Positives = 100/256 (39%), Gaps = 42/256 (16%)
Query: 212 YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGG 271
+ G++VGA +G L+DR GRR+ LL++ V S+ Y F R L+G + G
Sbjct: 150 FAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAG 209
Query: 272 SIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFH 331
IV E+L E R FW GGV A+ Y
Sbjct: 210 FTIIVMPLELEWLDVEHRTVAGVLSSTFW-TGGVMLLALV---------------GYLIR 253
Query: 332 SWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERV 391
WR +L P I +L PES R+ L G EA L +H + + E
Sbjct: 254 DWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYL--LHCARLNGRPVCEDS 311
Query: 392 FSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF-GPEYRRITLMM 450
FS + + + ++ S +L F P R I+L
Sbjct: 312 FSQEAVSKVAAGERVVRRPS-----------------------YLDLFRTPRLRHISLCC 348
Query: 451 MGVWFTMSFSYYGLTV 466
+ VWF ++FSYYGL++
Sbjct: 349 VVVWFGVNFSYYGLSL 364
>gi|157426885 organic cation transporter like 4 [Homo sapiens]
Length = 594
Score = 68.2 bits (165), Expect = 3e-11
Identities = 70/288 (24%), Positives = 124/288 (43%), Gaps = 53/288 (18%)
Query: 187 GFVLPSAEKD--------MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLIS 238
G++ P A+K +C ++ K ++ G+ +G+ ++ + D++GR +L+S
Sbjct: 158 GWIYPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLS 217
Query: 239 LSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCM 298
L +F F ++F+ + +LF R + G S +E+L E R +
Sbjct: 218 LLGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGHC 277
Query: 299 FWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESP 358
F+ +G V +A++ +PH+ F +G +LV F I + PESP
Sbjct: 278 FFAVGAVLLTGIAYS-LPHWQLLFLVGG----------ILVIPF-----ISYIWILPESP 321
Query: 359 RFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQ 418
R+ + GK EA VL N KTI + L E+Q +
Sbjct: 322 RWLMMKGKVKEAKQVLCYAASVNK---------------KTI-PSNLLDELQLP-----R 360
Query: 419 RWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTV 466
+ RA L C + ++TL+M VWFT+S++Y+ L++
Sbjct: 361 KKVTRASVLD--------FCKNRQLCKVTLVMSCVWFTVSYTYFTLSL 400
Score = 40.8 bits (94), Expect = 0.005
Identities = 38/162 (23%), Positives = 66/162 (40%), Gaps = 20/162 (12%)
Query: 597 VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSF------------ 644
V+F + ++ +P + L+ +IGR LA + + + + C L F
Sbjct: 409 VHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKW 468
Query: 645 ----GNSESAMIALLCLFGGVSIASWNALDVL-TVELYPSDKRTTAFGFLNALCKLAAVL 699
+M L+ + S+A+ + L T EL P+ R T G ++ A+L
Sbjct: 469 PRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAIL 528
Query: 700 GISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL 741
++I + + PI + SL+ LPETR Q L
Sbjct: 529 SLTIISQTPSL---LPIFLCCVLAIVAFSLSSLLPETRDQPL 567
>gi|4507001 solute carrier family 22 member 2 [Homo sapiens]
Length = 555
Score = 67.4 bits (163), Expect = 5e-11
Identities = 63/267 (23%), Positives = 111/267 (41%), Gaps = 49/267 (18%)
Query: 202 SNKGMLGLI---VYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTF 258
+N ML L V +G +G+ G +ADR GR+ CLL ++ +N+ + Y
Sbjct: 144 ANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWM 203
Query: 259 LFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHY 318
L RL+ G+ I + +EF+ + R + + + +G + A +A+A +PH
Sbjct: 204 LIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYA-LPH- 261
Query: 319 GWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVH 378
WR A P+ F + PESPR+ + K+ EA ++K +
Sbjct: 262 --------------WRWLQFTVALPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIA 307
Query: 379 DTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSC 438
N K++ + + ++ +TG ++ +FL
Sbjct: 308 KKNG---------------KSLPASLQRLRLEEETGK--------------KLNPSFLDL 338
Query: 439 F-GPEYRRITLMMMGVWFTMSFSYYGL 464
P+ R+ T+++M WFT S Y GL
Sbjct: 339 VRTPQIRKHTMILMYNWFTSSVLYQGL 365
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/153 (22%), Positives = 67/153 (43%), Gaps = 5/153 (3%)
Query: 591 GEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSF--GNSE 648
G+ Y+ +F S L P + L +D+IGR A S++++ +C F G+ +
Sbjct: 373 GDNIYLDFFYS---ALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQ 429
Query: 649 SAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFV 708
I + CL ++ + ++ ELYP+ R +++C + ++ +
Sbjct: 430 WLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLT 489
Query: 709 GITKAAPILFASAALALGSSLALKLPETRGQVL 741
I P++ + L L LPET+G+ L
Sbjct: 490 NIWLELPLMVFGVLGLVAGGLVLLLPETKGKAL 522
>gi|23510410 solute carrier family 22 member 1 isoform b [Homo
sapiens]
Length = 506
Score = 66.2 bits (160), Expect = 1e-10
Identities = 62/252 (24%), Positives = 101/252 (40%), Gaps = 46/252 (18%)
Query: 214 GMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSI 273
G + G+ G ADR GR+ CLL ++ VN+V +F Y + L RLL G+ G+
Sbjct: 158 GFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNW 217
Query: 274 PIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSW 333
++ +EF+ R M + +G V +A+A +PH W
Sbjct: 218 MAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYA-LPH---------------W 261
Query: 334 RVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFS 393
R L + P+ + PESPR+ L ++ EA ++ + N +
Sbjct: 262 RWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK--------LP 313
Query: 394 VTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF-GPEYRRITLMMMG 452
+K + E+++ E S +F F P R+ T ++M
Sbjct: 314 PADLKMLSLEEDVTEKLSP---------------------SFADLFRTPRLRKRTFILMY 352
Query: 453 VWFTMSFSYYGL 464
+WFT S Y GL
Sbjct: 353 LWFTDSVLYQGL 364
Score = 35.4 bits (80), Expect = 0.19
Identities = 40/172 (23%), Positives = 77/172 (44%), Gaps = 26/172 (15%)
Query: 513 NDKFIGLRLKSVSFEDSLFEECY--FEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSR 570
N K LK +S E+ + E+ F D+ + R TFI + TD Y
Sbjct: 309 NGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRL-RKRTFILMYLWFTDSVLY------ 361
Query: 571 LINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAG 630
+G L + T Y+ + S L +PG ++ + +D++GR+ +A
Sbjct: 362 ----------QGLILHMGATSGNLYLDFLYS---ALVEIPGAFIALITIDRVGRIYPMAM 408
Query: 631 SSVMSCVSCFFLSFGNSES--AMIALLCLFG-GVSIASWNALDVLTVELYPS 679
S++++ +C + F + + I ++C+ G++IA + ++ ELYP+
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAI-QMICLVNAELYPT 459
>gi|4506999 solute carrier family 22 member 1 isoform a [Homo
sapiens]
Length = 554
Score = 66.2 bits (160), Expect = 1e-10
Identities = 62/252 (24%), Positives = 101/252 (40%), Gaps = 46/252 (18%)
Query: 214 GMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSI 273
G + G+ G ADR GR+ CLL ++ VN+V +F Y + L RLL G+ G+
Sbjct: 158 GFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNW 217
Query: 274 PIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSW 333
++ +EF+ R M + +G V +A+A +PH W
Sbjct: 218 MAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYA-LPH---------------W 261
Query: 334 RVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFS 393
R L + P+ + PESPR+ L ++ EA ++ + N +
Sbjct: 262 RWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK--------LP 313
Query: 394 VTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF-GPEYRRITLMMMG 452
+K + E+++ E S +F F P R+ T ++M
Sbjct: 314 PADLKMLSLEEDVTEKLSP---------------------SFADLFRTPRLRKRTFILMY 352
Query: 453 VWFTMSFSYYGL 464
+WFT S Y GL
Sbjct: 353 LWFTDSVLYQGL 364
Score = 54.7 bits (130), Expect = 3e-07
Identities = 54/234 (23%), Positives = 104/234 (44%), Gaps = 26/234 (11%)
Query: 513 NDKFIGLRLKSVSFEDSLFEECY--FEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSR 570
N K LK +S E+ + E+ F D+ + R TFI + TD Y
Sbjct: 309 NGKLPPADLKMLSLEEDVTEKLSPSFADLFRTPRL-RKRTFILMYLWFTDSVLY------ 361
Query: 571 LINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAG 630
+G L + T Y+ + S L +PG ++ + +D++GR+ +A
Sbjct: 362 ----------QGLILHMGATSGNLYLDFLYS---ALVEIPGAFIALITIDRVGRIYPMAM 408
Query: 631 SSVMSCVSCFFLSFGNSESAM--IALLCLFG-GVSIASWNALDVLTVELYPSDKRTTAFG 687
S++++ +C + F + + I ++C+ G++IA + ++ ELYP+ R
Sbjct: 409 SNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAI-QMICLVNAELYPTFVRNLGVM 467
Query: 688 FLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL 741
++LC + ++ I + +A P++ + L + + L LPET+G L
Sbjct: 468 VCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAGVTLLLPETKGVAL 521
>gi|166197673 solute carrier family 22, member 15 [Homo sapiens]
Length = 547
Score = 65.5 bits (158), Expect = 2e-10
Identities = 64/263 (24%), Positives = 101/263 (38%), Gaps = 52/263 (19%)
Query: 212 YLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGG 271
+ G+ VG +G L+DR GR++ L +++ +FA + F Y F R L G+ GG
Sbjct: 119 FSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMNGG 178
Query: 272 SIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFH 331
+ F +E + ++ + IGG++ A G + Y
Sbjct: 179 MSLVAFVLLNECVG-------TAYWALAGSIGGLFFAV---------GIAQYALLGYFIR 222
Query: 332 SWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERV 391
SWR ++ PESPR+ G+ EA L + N + K
Sbjct: 223 SWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLK----CT 278
Query: 392 FSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRI---TL 448
FS+TH + + G+FL F YR + TL
Sbjct: 279 FSLTH---------------------------PANRSCRETGSFLDLF--RYRVLLGHTL 309
Query: 449 MMMGVWFTMSFSYYGLTVWFPDM 471
++M +WF S YYGLT+ D+
Sbjct: 310 ILMFIWFVCSLVYYGLTLSAGDL 332
>gi|24497490 solute carrier family 22 member 4 [Homo sapiens]
Length = 551
Score = 63.2 bits (152), Expect = 9e-10
Identities = 47/199 (23%), Positives = 91/199 (45%), Gaps = 18/199 (9%)
Query: 210 IVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGI 269
+ ++G+++G+F+ G L+DR GR+ L +++V + F+F F + F ++ G+G
Sbjct: 148 LFFVGVLLGSFVSGQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQ 207
Query: 270 GGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQ 329
+ + F +E L + R +F +G A+ + ++P + AY
Sbjct: 208 ISNYVVAFILGTEILGKSVR-------IIFSTLGVCTFFAVGYMLLPLF--------AYF 252
Query: 330 FHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPE 389
WR+ +L P V + PESPR+ + + EA ++++ N A P
Sbjct: 253 IRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAV--PA 310
Query: 390 RVF-SVTHIKTIHQEDELI 407
+F SV + + Q+ I
Sbjct: 311 VIFDSVEELNPLKQQKAFI 329
>gi|11415038 solute carrier family 22 member 3 [Homo sapiens]
Length = 556
Score = 60.8 bits (146), Expect = 4e-09
Identities = 67/268 (25%), Positives = 105/268 (39%), Gaps = 51/268 (19%)
Query: 203 NKGMLGL---IVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFL 259
N ML L I+ LG + GAF G ADR GR L+S V +F + F+
Sbjct: 150 NAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFV 209
Query: 260 FCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYG 319
R L GV G+ + +E + ++R + MF+ +G + I+P
Sbjct: 210 IFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGII--------ILP--- 258
Query: 320 WSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHD 379
G AY +W+ L PS + PESPR+ + K D+A +L+++
Sbjct: 259 -----GIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAK 313
Query: 380 TNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCF 439
N + + ++ I DE + S FL
Sbjct: 314 CNGK--------YLSSNYSEITVTDEEVSNPS-----------------------FLDLV 342
Query: 440 -GPEYRRITLMMMGVWFTMSFSYYGLTV 466
P+ R+ TL++M WFT + Y GL +
Sbjct: 343 RTPQMRKCTLILMFAWFTSAVVYQGLVM 370
Score = 49.7 bits (117), Expect = 1e-05
Identities = 31/147 (21%), Positives = 66/147 (44%), Gaps = 2/147 (1%)
Query: 597 VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMI-ALL 655
+Y F+ + LPG ++ L ++++GR A S++++ V+C +F A + +
Sbjct: 379 LYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTV 438
Query: 656 CLFGGVSIA-SWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAA 714
G + I ++ + ++ ELYP+ R + LC ++ + +
Sbjct: 439 ATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLEL 498
Query: 715 PILFASAALALGSSLALKLPETRGQVL 741
P++ ++ L + LPET+G L
Sbjct: 499 PLIIFGILASICGGLVMLLPETKGIAL 525
>gi|24497480 solute carrier family 22 member 6 isoform d [Homo
sapiens]
Length = 519
Score = 58.9 bits (141), Expect = 2e-08
Identities = 76/314 (24%), Positives = 126/314 (40%), Gaps = 52/314 (16%)
Query: 165 QWTLYFVLGLALMADGV-EVFVVGFVLPSA--------EKDMCLSDSNKGMLGLIVYL-G 214
QW L F+ G G E G++ ++ E D+ S L +Y+ G
Sbjct: 85 QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144
Query: 215 MMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIP 274
+++GA ++G LADRLGRR+ L+++ +V ++F + + RLLSG+ + G
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204
Query: 275 IVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWR 334
+ E++ R C+ +IG VY+ G G AY WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248
Query: 335 VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSV 394
L+ + P ES R+ +G+ D L++V + K S+
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV--ARINGKREEGAKLSM 306
Query: 395 THIKTIHQEDELIEIQSDTGTWYQRWGVRALSLG-GQVWG-NFLSCFGPEYRRITLMMMG 452
++ Q++ L++G GQ L C P R + L +
Sbjct: 307 EVLRASLQKE--------------------LTMGKGQASAMELLRC--PTLRHLFLCLSM 344
Query: 453 VWFTMSFSYYGLTV 466
+WF SF+YYGL +
Sbjct: 345 LWFATSFAYYGLVM 358
Score = 32.0 bits (71), Expect = 2.1
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 582 GCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFF 641
G +D+ G G Y++ + G + LP +V L+++ +GR R ++++ C
Sbjct: 355 GLVMDLQGFGVSIYLIQVI--FGAVD-LPAKLVGFLVINSLGR-RPAQMAALLLAGICIL 410
Query: 642 LS--FGNSESAMIALLCLFG-GVSIASWNALDVLTVELYPS 679
L+ +S + L + G G AS+N + + T ELYP+
Sbjct: 411 LNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPT 451
>gi|24497478 solute carrier family 22 member 6 isoform c [Homo
sapiens]
Length = 506
Score = 58.9 bits (141), Expect = 2e-08
Identities = 76/314 (24%), Positives = 126/314 (40%), Gaps = 52/314 (16%)
Query: 165 QWTLYFVLGLALMADGV-EVFVVGFVLPSA--------EKDMCLSDSNKGMLGLIVYL-G 214
QW L F+ G G E G++ ++ E D+ S L +Y+ G
Sbjct: 85 QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144
Query: 215 MMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIP 274
+++GA ++G LADRLGRR+ L+++ +V ++F + + RLLSG+ + G
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204
Query: 275 IVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWR 334
+ E++ R C+ +IG VY+ G G AY WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248
Query: 335 VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSV 394
L+ + P ES R+ +G+ D L++V + K S+
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV--ARINGKREEGAKLSM 306
Query: 395 THIKTIHQEDELIEIQSDTGTWYQRWGVRALSLG-GQVWG-NFLSCFGPEYRRITLMMMG 452
++ Q++ L++G GQ L C P R + L +
Sbjct: 307 EVLRASLQKE--------------------LTMGKGQASAMELLRC--PTLRHLFLCLSM 344
Query: 453 VWFTMSFSYYGLTV 466
+WF SF+YYGL +
Sbjct: 345 LWFATSFAYYGLVM 358
Score = 32.0 bits (71), Expect = 2.1
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 7/101 (6%)
Query: 582 GCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFF 641
G +D+ G G Y++ + G + LP +V L+++ +GR R ++++ C
Sbjct: 355 GLVMDLQGFGVSIYLIQVI--FGAVD-LPAKLVGFLVINSLGR-RPAQMAALLLAGICIL 410
Query: 642 LS--FGNSESAMIALLCLFG-GVSIASWNALDVLTVELYPS 679
L+ +S + L + G G AS+N + + T ELYP+
Sbjct: 411 LNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPT 451
>gi|24497476 solute carrier family 22 member 6 isoform b [Homo
sapiens]
Length = 550
Score = 58.9 bits (141), Expect = 2e-08
Identities = 76/314 (24%), Positives = 126/314 (40%), Gaps = 52/314 (16%)
Query: 165 QWTLYFVLGLALMADGV-EVFVVGFVLPSA--------EKDMCLSDSNKGMLGLIVYL-G 214
QW L F+ G G E G++ ++ E D+ S L +Y+ G
Sbjct: 85 QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144
Query: 215 MMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIP 274
+++GA ++G LADRLGRR+ L+++ +V ++F + + RLLSG+ + G
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204
Query: 275 IVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWR 334
+ E++ R C+ +IG VY+ G G AY WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248
Query: 335 VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSV 394
L+ + P ES R+ +G+ D L++V + K S+
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV--ARINGKREEGAKLSM 306
Query: 395 THIKTIHQEDELIEIQSDTGTWYQRWGVRALSLG-GQVWG-NFLSCFGPEYRRITLMMMG 452
++ Q++ L++G GQ L C P R + L +
Sbjct: 307 EVLRASLQKE--------------------LTMGKGQASAMELLRC--PTLRHLFLCLSM 344
Query: 453 VWFTMSFSYYGLTV 466
+WF SF+YYGL +
Sbjct: 345 LWFATSFAYYGLVM 358
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/163 (24%), Positives = 78/163 (47%), Gaps = 8/163 (4%)
Query: 582 GCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFF 641
G +D+ G G Y++ + G + LP +V L+++ +GR R ++++ C
Sbjct: 355 GLVMDLQGFGVSIYLIQVI--FGAVD-LPAKLVGFLVINSLGR-RPAQMAALLLAGICIL 410
Query: 642 LS--FGNSESAMIALLCLFG-GVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAV 698
L+ +S + L + G G AS+N + + T ELYP+ R T G + + ++ ++
Sbjct: 411 LNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSI 470
Query: 699 LGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL 741
+ + + + + P+ A S++ + LPET GQ L
Sbjct: 471 VS-PLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512
>gi|20070188 solute carrier family 22 member 6 isoform a [Homo
sapiens]
Length = 563
Score = 58.9 bits (141), Expect = 2e-08
Identities = 76/314 (24%), Positives = 126/314 (40%), Gaps = 52/314 (16%)
Query: 165 QWTLYFVLGLALMADGV-EVFVVGFVLPSA--------EKDMCLSDSNKGMLGLIVYL-G 214
QW L F+ G G E G++ ++ E D+ S L +Y+ G
Sbjct: 85 QWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVG 144
Query: 215 MMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIP 274
+++GA ++G LADRLGRR+ L+++ +V ++F + + RLLSG+ + G
Sbjct: 145 VLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISL 204
Query: 275 IVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWR 334
+ E++ R C+ +IG VY+ G G AY WR
Sbjct: 205 NCMTLNVEWMPIHTRA------CVGTLIGYVYS----------LGQFLLAGVAYAVPHWR 248
Query: 335 VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSV 394
L+ + P ES R+ +G+ D L++V + K S+
Sbjct: 249 HLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRV--ARINGKREEGAKLSM 306
Query: 395 THIKTIHQEDELIEIQSDTGTWYQRWGVRALSLG-GQVWG-NFLSCFGPEYRRITLMMMG 452
++ Q++ L++G GQ L C P R + L +
Sbjct: 307 EVLRASLQKE--------------------LTMGKGQASAMELLRC--PTLRHLFLCLSM 344
Query: 453 VWFTMSFSYYGLTV 466
+WF SF+YYGL +
Sbjct: 345 LWFATSFAYYGLVM 358
Score = 48.5 bits (114), Expect = 2e-05
Identities = 40/163 (24%), Positives = 78/163 (47%), Gaps = 8/163 (4%)
Query: 582 GCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFF 641
G +D+ G G Y++ + G + LP +V L+++ +GR R ++++ C
Sbjct: 355 GLVMDLQGFGVSIYLIQVI--FGAVD-LPAKLVGFLVINSLGR-RPAQMAALLLAGICIL 410
Query: 642 LS--FGNSESAMIALLCLFG-GVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAV 698
L+ +S + L + G G AS+N + + T ELYP+ R T G + + ++ ++
Sbjct: 411 LNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSI 470
Query: 699 LGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVL 741
+ + + + + P+ A S++ + LPET GQ L
Sbjct: 471 VS-PLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512
>gi|24497499 solute carrier family 22 member 8 [Homo sapiens]
Length = 542
Score = 57.8 bits (138), Expect = 4e-08
Identities = 66/272 (24%), Positives = 108/272 (39%), Gaps = 42/272 (15%)
Query: 197 MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG 256
+C S+ K M I G+++G + G L+DR GRR L S + + ++F +
Sbjct: 115 VCNSNKLKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFP 174
Query: 257 TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIP 316
++ R L G GI G E++ R M +G Y
Sbjct: 175 IYMVFRFLCGFGISGITLSTVILNVEWVPTRMRA------IMSTALGYCYT--------- 219
Query: 317 HYGWSFQMGSAYQFHSWRVFVLVCAFP-SVFAIGALTTQPESPRFFLENGKHDEAWMVLK 375
+G G AY WR L + P VF + + T PES R+ + +GK +A +L+
Sbjct: 220 -FGQFILPGLAYAIPQWRWLQLTVSIPFFVFFLSSWWT-PESIRWLVLSGKSSKALKILR 277
Query: 376 QVHDTNMRAKGHPERVFSVTHIK-TIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGN 434
+V N + K ER+ S+ +K + +E L + + ++
Sbjct: 278 RVAVFNGK-KEEGERL-SLEELKLNLQKEISLAKAKYTASDLFRI--------------- 320
Query: 435 FLSCFGPEYRRITLMMMGVWFTMSFSYYGLTV 466
P RR+T + WF F+YY L +
Sbjct: 321 ------PMLRRMTFCLSLAWFATGFAYYSLAM 346
>gi|31542327 solute carrier family 22, member 16 [Homo sapiens]
Length = 577
Score = 56.2 bits (134), Expect = 1e-07
Identities = 38/161 (23%), Positives = 72/161 (44%), Gaps = 16/161 (9%)
Query: 214 GMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSI 273
G+++G+ +G +DRLGRR L + S +F ++F Y TF+ R + G +
Sbjct: 164 GVLLGSVTFGYFSDRLGRRVVLWATSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYL 223
Query: 274 PIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSW 333
+ F Y EF+ + R L F+ +G + A + Y +W
Sbjct: 224 VVGFVYVMEFIGMKSRTWASVHLHSFFAVGTLLVAL----------------TGYLVRTW 267
Query: 334 RVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVL 374
++ ++ + +V I PE+P + L G+++EA ++
Sbjct: 268 WLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIV 308
Score = 55.8 bits (133), Expect = 1e-07
Identities = 45/147 (30%), Positives = 74/147 (50%), Gaps = 5/147 (3%)
Query: 598 YFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALL-C 656
Y FL + +P + MDK+GR +LA S S ++C + + ++ ++
Sbjct: 388 YLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGVVMVIPQKHYILGVVTA 447
Query: 657 LFGGVSI-ASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLG-ISIFTSFVGITKAA 714
+ G +I A++ + + T ELYP+ R+ A G + +C+LA++L S+ S + I
Sbjct: 448 MVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSVDLSSIWI--FI 505
Query: 715 PILFASAALALGSSLALKLPETRGQVL 741
P LF L L LKLPET G+ L
Sbjct: 506 PQLFVGTMALLSGVLTLKLPETLGKRL 532
>gi|33457322 SVOP-like isoform 2 [Homo sapiens]
Length = 340
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/151 (25%), Positives = 70/151 (46%), Gaps = 8/151 (5%)
Query: 595 YMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFG--NSESAMI 652
Y +S +G +A+ P NI+ + R L+ S M C + FFL S + +I
Sbjct: 192 YRTMIISTIGEIALNPLNILGINFLG-----RRLSLSITMGCTALFFLLLNICTSSAGLI 246
Query: 653 ALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITK 712
L + + A++N + + T E+YP+ R G +LC++ A++ I + +
Sbjct: 247 GFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI 306
Query: 713 AAPILFASAALALGSSLALKLP-ETRGQVLQ 742
+ S+ + + A LP ET+G+ LQ
Sbjct: 307 LGALCLFSSVCVVCAISAFTLPIETKGRALQ 337
Score = 53.1 bits (126), Expect = 9e-07
Identities = 45/184 (24%), Positives = 69/184 (37%), Gaps = 47/184 (25%)
Query: 281 SEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVC 340
+EFL + RG L +FW+ G + +A IIP G WR + V
Sbjct: 10 TEFLPTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVA 56
Query: 341 AFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTI 400
+ P + I A PES RF + G A L++V N +++
Sbjct: 57 SIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMN----------------RSV 100
Query: 401 HQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFS 460
E +L+E + G F +Y R TL + +W +SF+
Sbjct: 101 MPEGKLVEPVLEKR------------------GRFADLLDAKYLRTTLQIWVIWLGISFA 142
Query: 461 YYGL 464
YYG+
Sbjct: 143 YYGV 146
>gi|21361449 solute carrier family 2 (facilitated glucose
transporter), member 8 [Homo sapiens]
Length = 477
Score = 53.9 bits (128), Expect = 5e-07
Identities = 51/179 (28%), Positives = 76/179 (42%), Gaps = 21/179 (11%)
Query: 199 LSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLI-SLSVNSVFAFFSSFVQGYGT 257
L D+ G +V LG G L G L DR GR+ LL+ S+ + FA ++ Q
Sbjct: 64 LDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITA-AQDVWM 122
Query: 258 FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPH 317
L RLL+G+ G + + Y SE RG S + + ++G + A W +
Sbjct: 123 LLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVL--- 179
Query: 318 YGWSFQMGSAYQFHSWR-VFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLK 375
WR + VL C PS+ + + PE+PRF L + EA L+
Sbjct: 180 --------------EWRWLAVLGCVPPSLMLL-LMCFMPETPRFLLTQHRRQEAMAALR 223
>gi|8923870 solute carrier family 22 member 11 [Homo sapiens]
Length = 550
Score = 53.5 bits (127), Expect = 7e-07
Identities = 43/170 (25%), Positives = 79/170 (46%), Gaps = 5/170 (2%)
Query: 571 LINSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAG 630
++N + L + G D+ G +++ + G + L G +ALL+ +GR + AG
Sbjct: 351 VVNFSLLISYYGLVFDLQSLGRDIFLLQ--ALFGAVDFL-GRATTALLLSFLGRRTIQAG 407
Query: 631 SSVMSCVSCF--FLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGF 688
S M+ ++ L + ++ + L G S L + EL+P+ R TA G
Sbjct: 408 SQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGI 467
Query: 689 LNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRG 738
L+ + +L A++G I S + P+L+ ++A + LPET+G
Sbjct: 468 LHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQG 517
Score = 52.8 bits (125), Expect = 1e-06
Identities = 70/315 (22%), Positives = 120/315 (38%), Gaps = 41/315 (13%)
Query: 197 MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG 256
+C S K + I G++VG+F+WG L+ R GR+ L +V + F +
Sbjct: 135 VCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFV 194
Query: 257 TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIP 316
+ R ++ G+ G + E+ +R ++ ++G ++A
Sbjct: 195 IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMT------VVGCAFSA-------- 240
Query: 317 HYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALT-TQPESPRFFLENGKHDEAWMVLK 375
G + G A+ WR L + P FAI ++ PES R+ + GK D+A L+
Sbjct: 241 --GQAALGGLAFALRDWRTLQLAASVP-FFAISLISWWLPESARWLIIKGKPDQALQELR 297
Query: 376 QVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNF 435
+V R GH E K + E + ++ + + + V
Sbjct: 298 KV----ARINGHKE-------AKNLTIEVLMSSVKEEVASAKEPRSVLD----------- 335
Query: 436 LSCFGPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYASRTKVFPGERVEHV 495
L C P R + M+ V F++ SYYGL + R + + F G +
Sbjct: 336 LFCV-PVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTAL 394
Query: 496 TFNFTLENQIHRGGQ 510
+F I G Q
Sbjct: 395 LLSFLGRRTIQAGSQ 409
>gi|238814326 solute carrier family 22, member 20 [Homo sapiens]
Length = 555
Score = 52.8 bits (125), Expect = 1e-06
Identities = 61/277 (22%), Positives = 107/277 (38%), Gaps = 52/277 (18%)
Query: 197 MCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG 256
+C + + + + + G++VGA ++G LADRLG + L+ S + +++ +
Sbjct: 129 VCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAATAYFSSFS 188
Query: 257 TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIP 316
+ R L G+ G I S E++ R + G+
Sbjct: 189 AYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGR-----------TVAGIL---------- 227
Query: 317 HYGWSFQMGS------AYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEA 370
G+SF +G AY WR + P + PES R+ L +GK A
Sbjct: 228 -LGYSFTLGQLILAGVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLA 286
Query: 371 WMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQ 430
L++V N R K ER+ + + + + E + +
Sbjct: 287 VQNLQKVAAMNGR-KEEGERL--TKEVMSSYIQSEFASVCTS------------------ 325
Query: 431 VWGNFLSCF-GPEYRRITLMMMGVWFTMSFSYYGLTV 466
+ L F P R++T +M +WF+ S +YYGL +
Sbjct: 326 --NSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAM 360
Score = 37.0 bits (84), Expect = 0.066
Identities = 35/148 (23%), Positives = 65/148 (43%), Gaps = 5/148 (3%)
Query: 597 VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMS---CVSCFFLSFGNSESAMIA 653
+Y V L + P +V+ M +GR +A +++ ++ F+ G ++ A
Sbjct: 369 LYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEG-TQILCTA 427
Query: 654 LLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKA 713
L G +S+ + + T ELYP++ R GF + +L + + T T
Sbjct: 428 QAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTLGEYSTIL 487
Query: 714 APILFASAALALGSSLALKLPETRGQVL 741
P+ F + A+ G ++ + L ETR L
Sbjct: 488 PPVSFGATAILAGLAVCV-LTETRNMPL 514
>gi|190684655 glucose transporter protein 10 isoform a [Homo
sapiens]
Length = 503
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/157 (29%), Positives = 70/157 (44%), Gaps = 22/157 (14%)
Query: 213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGY----GTF---LFCRLLS 265
LG + GA L G LA LGR++ LL VN++F ++ + G+ G+F + RLL
Sbjct: 83 LGGLFGALLAGPLAITLGRKKSLL----VNNIFVVSAAILFGFSRKAGSFEMIMLGRLLV 138
Query: 266 GVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMG 325
GV G S+ I Y E +E RG +F +G V + G +G
Sbjct: 139 GVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVV--------GLRELLG 190
Query: 326 SAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFL 362
+W + + C P + +L PESPR+ L
Sbjct: 191 GP---QAWPLLLASCLVPGALQLASLPLLPESPRYLL 224
>gi|68226420 glucose transporter protein 10 isoform c [Homo sapiens]
Length = 496
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/157 (29%), Positives = 70/157 (44%), Gaps = 22/157 (14%)
Query: 213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGY----GTF---LFCRLLS 265
LG + GA L G LA LGR++ LL VN++F ++ + G+ G+F + RLL
Sbjct: 76 LGGLFGALLAGPLAITLGRKKSLL----VNNIFVVSAAILFGFSRKAGSFEMIMLGRLLV 131
Query: 266 GVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMG 325
GV G S+ I Y E +E RG +F +G V + G +G
Sbjct: 132 GVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVV--------GLRELLG 183
Query: 326 SAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFL 362
+W + + C P + +L PESPR+ L
Sbjct: 184 GP---QAWPLLLASCLVPGALQLASLPLLPESPRYLL 217
>gi|68226418 glucose transporter protein 10 isoform b [Homo sapiens]
Length = 499
Score = 52.4 bits (124), Expect = 2e-06
Identities = 47/157 (29%), Positives = 70/157 (44%), Gaps = 22/157 (14%)
Query: 213 LGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGY----GTF---LFCRLLS 265
LG + GA L G LA LGR++ LL VN++F ++ + G+ G+F + RLL
Sbjct: 79 LGGLFGALLAGPLAITLGRKKSLL----VNNIFVVSAAILFGFSRKAGSFEMIMLGRLLV 134
Query: 266 GVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMG 325
GV G S+ I Y E +E RG +F +G V + G +G
Sbjct: 135 GVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVV--------GLRELLG 186
Query: 326 SAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFL 362
+W + + C P + +L PESPR+ L
Sbjct: 187 GP---QAWPLLLASCLVPGALQLASLPLLPESPRYLL 220
>gi|215490102 spinster homolog 1 isoform 3 [Homo sapiens]
Length = 476
Score = 49.7 bits (117), Expect = 1e-05
Identities = 49/186 (26%), Positives = 76/186 (40%), Gaps = 5/186 (2%)
Query: 114 ADGAPLAGVRGGLSDGE--GPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQWTLYF- 170
+D AP DG G PG G K E E + R G + L
Sbjct: 4 SDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSALIVA 63
Query: 171 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLG 230
VL + + ++ F V VLP E+ + DS+ G++ + MV A ++G L DR
Sbjct: 64 VLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYN 123
Query: 231 RRQCLLISLSVNSVFAFFSSFVQG--YGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 288
R+ + ++ S+ SSF+ G + L R L GVG I + ++ ++
Sbjct: 124 RKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQ 183
Query: 289 RGEHLS 294
R LS
Sbjct: 184 RSRMLS 189
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,506,931
Number of Sequences: 37866
Number of extensions: 1375318
Number of successful extensions: 6924
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 141
Number of HSP's that attempted gapping in prelim test: 5862
Number of HSP's gapped (non-prelim): 913
length of query: 742
length of database: 18,247,518
effective HSP length: 110
effective length of query: 632
effective length of database: 14,082,258
effective search space: 8899987056
effective search space used: 8899987056
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.