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Search of human proteins with 21624639
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
(337 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens] 690 0.0
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens] 634 0.0
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens] 619 e-177
gi|23199991 casein kinase 1 epsilon [Homo sapiens] 456 e-128
gi|4503093 casein kinase 1 epsilon [Homo sapiens] 456 e-128
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens] 456 e-128
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens] 456 e-128
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens] 321 7e-88
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens] 321 7e-88
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens] 320 9e-88
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens] 320 9e-88
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens] 319 3e-87
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens] 316 2e-86
gi|58761548 tau tubulin kinase 1 [Homo sapiens] 161 9e-40
gi|116812624 tau tubulin kinase 2 [Homo sapiens] 157 2e-38
gi|4507903 vaccinia related kinase 1 [Homo sapiens] 111 1e-24
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens] 106 3e-23
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens] 106 3e-23
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens] 106 3e-23
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens] 106 3e-23
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens] 106 3e-23
gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens] 90 2e-18
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens] 67 3e-11
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens] 67 3e-11
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 65 7e-11
gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens] 65 9e-11
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 65 9e-11
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 65 1e-10
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 65 1e-10
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 63 3e-10
>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
Length = 337
Score = 690 bits (1781), Expect = 0.0
Identities = 337/337 (100%), Positives = 337/337 (100%)
Query: 1 MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYE 60
MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYE
Sbjct: 1 MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYE 60
Query: 61 SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKH 180
ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKH
Sbjct: 121 ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKH 180
Query: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK
Sbjct: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM
Sbjct: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
Query: 301 LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVKDN 337
LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVKDN
Sbjct: 301 LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVKDN 337
>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
Length = 337
Score = 634 bits (1635), Expect = 0.0
Identities = 307/335 (91%), Positives = 318/335 (94%)
Query: 1 MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYE 60
M ++SGSKAE +VGGKYKLVRKIGSGSFGD+YL I TNGEEVAVKLESQK +HPQLLYE
Sbjct: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
Query: 61 SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLY ILQGGVGIPH+ WYGQEKD NVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKH 180
ISRIEYVHTKNF+HRDIKPDNFLMG GRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDK+
Sbjct: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN 180
Query: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
L GT RYASINAHLGIEQSRRDDMESLGYV MYFNRTSLPWQGLKA TKKQKYEKISEKK
Sbjct: 181 LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK 240
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEE PDYMYLRQLFRILFRTLNHQYDYTFDWTM
Sbjct: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
Query: 301 LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVK 335
LKQKAAQQAASSSGQGQQAQT TGKQT+K K+N+K
Sbjct: 301 LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMK 335
>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
Length = 365
Score = 619 bits (1596), Expect = e-177
Identities = 307/363 (84%), Positives = 318/363 (87%), Gaps = 28/363 (7%)
Query: 1 MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYE 60
M ++SGSKAE +VGGKYKLVRKIGSGSFGD+YL I TNGEEVAVKLESQK +HPQLLYE
Sbjct: 1 MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE 60
Query: 61 SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
SKLY ILQGGVGIPH+ WYGQEKD NVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
Sbjct: 61 SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
Query: 121 ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNK---------------------------- 152
ISRIEYVHTKNF+HRDIKPDNFLMG GRHCNK
Sbjct: 121 ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQ 180
Query: 153 LFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFM 212
LFLIDFGLAKKYRDNRTRQHIPYREDK+L GT RYASINAHLGIEQSRRDDMESLGYV M
Sbjct: 181 LFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLM 240
Query: 213 YFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVP 272
YFNRTSLPWQGLKA TKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEE P
Sbjct: 241 YFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAP 300
Query: 273 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTQTGKQTEKNKN 332
DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQT TGKQT+K K+
Sbjct: 301 DYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKS 360
Query: 333 NVK 335
N+K
Sbjct: 361 NMK 363
>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 456 bits (1174), Expect = e-128
Identities = 216/298 (72%), Positives = 250/298 (83%)
Query: 10 ELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQG 69
EL VG KY+L RKIGSGSFGD+YLG +GEEVA+KLE K KHPQL ESK Y ++QG
Sbjct: 2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQG 61
Query: 70 GVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP + W G E D NV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYAS 189
KNF+HRD+KPDNFLMG G+ N +++IDFGLAKKYRD RT QHIPYRE+K+L GT RYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYV MYFN SLPWQGLKA TK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQ 307
KG+P+EF+ YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK AA+
Sbjct: 242 KGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAAR 299
>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
Length = 416
Score = 456 bits (1174), Expect = e-128
Identities = 216/298 (72%), Positives = 250/298 (83%)
Query: 10 ELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQG 69
EL VG KY+L RKIGSGSFGD+YLG +GEEVA+KLE K KHPQL ESK Y ++QG
Sbjct: 2 ELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQG 61
Query: 70 GVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP + W G E D NV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYAS 189
KNF+HRD+KPDNFLMG G+ N +++IDFGLAKKYRD RT QHIPYRE+K+L GT RYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYV MYFN SLPWQGLKA TK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQ 307
KG+P+EF+ YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK AA+
Sbjct: 242 KGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAAR 299
>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
Length = 409
Score = 456 bits (1172), Expect = e-128
Identities = 216/300 (72%), Positives = 251/300 (83%)
Query: 10 ELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQG 69
EL VG +Y+L RKIGSGSFGD+YLG GEEVA+KLE K KHPQL ESK+Y ++QG
Sbjct: 2 ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQG 61
Query: 70 GVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP + W G E D NV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYAS 189
KNF+HRD+KPDNFLMG G+ N +++IDFGLAKKYRD RT QHIPYRE+K+L GT RYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYV MYFN SLPWQGLKA TK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQA 309
KG+P+EFA YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK A++ A
Sbjct: 242 KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAA 301
>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
Length = 415
Score = 456 bits (1172), Expect = e-128
Identities = 216/300 (72%), Positives = 251/300 (83%)
Query: 10 ELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQG 69
EL VG +Y+L RKIGSGSFGD+YLG GEEVA+KLE K KHPQL ESK+Y ++QG
Sbjct: 2 ELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQG 61
Query: 70 GVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHT 129
GVGIP + W G E D NV+VM+LLGPSLEDLFNFCSR+F++KTVL+LADQMISRIEY+H+
Sbjct: 62 GVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHS 121
Query: 130 KNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYAS 189
KNF+HRD+KPDNFLMG G+ N +++IDFGLAKKYRD RT QHIPYRE+K+L GT RYAS
Sbjct: 122 KNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYAS 181
Query: 190 INAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVLC 249
IN HLGIEQSRRDD+ESLGYV MYFN SLPWQGLKA TK+QKYE+ISEKKMSTP+EVLC
Sbjct: 182 INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLC 241
Query: 250 KGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQA 309
KG+P+EFA YLN+CR LRF++ PDY YLRQLFR LF YDY FDW MLK A++ A
Sbjct: 242 KGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAA 301
>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
Length = 455
Score = 321 bits (822), Expect = 7e-88
Identities = 172/337 (51%), Positives = 228/337 (67%), Gaps = 13/337 (3%)
Query: 5 SGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLY 64
S S L+VG +++ +KIG G+FG++ LG E VA+KLE K + PQL E + Y
Sbjct: 31 SSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY 90
Query: 65 TILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRI 124
L G GIP ++++G N +V++LLGPSLEDLF+ C R F++KTVLM+A Q+ISR+
Sbjct: 91 KQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRM 150
Query: 125 EYVHTKNFLHRDIKPDNFLMGTGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYREDKH 180
EYVH+KN ++RD+KP+NFL+ GR NK + +IDFGLAK+Y D T++HIPYRE K
Sbjct: 151 EYVHSKNLIYRDVKPENFLI--GRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
Query: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
L GT RY SIN HLG EQSRRDD+E+LG++FMYF R SLPWQGLKA T K++Y+KI + K
Sbjct: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 268
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
+TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW +
Sbjct: 269 RATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW-I 326
Query: 301 LKQ-----KAAQQAASSSGQGQQAQTQTGKQTEKNKN 332
KQ A QQ + S + Q + Q KN++
Sbjct: 327 GKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQS 363
>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
Length = 447
Score = 321 bits (822), Expect = 7e-88
Identities = 172/337 (51%), Positives = 228/337 (67%), Gaps = 13/337 (3%)
Query: 5 SGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLY 64
S S L+VG +++ +KIG G+FG++ LG E VA+KLE K + PQL E + Y
Sbjct: 31 SSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY 90
Query: 65 TILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRI 124
L G GIP ++++G N +V++LLGPSLEDLF+ C R F++KTVLM+A Q+ISR+
Sbjct: 91 KQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRM 150
Query: 125 EYVHTKNFLHRDIKPDNFLMGTGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYREDKH 180
EYVH+KN ++RD+KP+NFL+ GR NK + +IDFGLAK+Y D T++HIPYRE K
Sbjct: 151 EYVHSKNLIYRDVKPENFLI--GRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
Query: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
L GT RY SIN HLG EQSRRDD+E+LG++FMYF R SLPWQGLKA T K++Y+KI + K
Sbjct: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 268
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
+TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW +
Sbjct: 269 RATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW-I 326
Query: 301 LKQ-----KAAQQAASSSGQGQQAQTQTGKQTEKNKN 332
KQ A QQ + S + Q + Q KN++
Sbjct: 327 GKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQS 363
>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
Length = 415
Score = 320 bits (821), Expect = 9e-88
Identities = 172/336 (51%), Positives = 227/336 (67%), Gaps = 13/336 (3%)
Query: 5 SGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLY 64
S S L+VG +++ +KIG G+FG++ LG E VA+KLE K + PQL E + Y
Sbjct: 31 SSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY 90
Query: 65 TILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRI 124
L G GIP ++++G N +V++LLGPSLEDLF+ C R F++KTVLM+A Q+ISR+
Sbjct: 91 KQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRM 150
Query: 125 EYVHTKNFLHRDIKPDNFLMGTGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYREDKH 180
EYVH+KN ++RD+KP+NFL+ GR NK + +IDFGLAK+Y D T++HIPYRE K
Sbjct: 151 EYVHSKNLIYRDVKPENFLI--GRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
Query: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
L GT RY SIN HLG EQSRRDD+E+LG++FMYF R SLPWQGLKA T K++Y+KI + K
Sbjct: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 268
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
+TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW +
Sbjct: 269 RATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW-I 326
Query: 301 LKQ-----KAAQQAASSSGQGQQAQTQTGKQTEKNK 331
KQ A QQ + S + Q + Q KN+
Sbjct: 327 GKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ 362
>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
Length = 423
Score = 320 bits (821), Expect = 9e-88
Identities = 172/336 (51%), Positives = 227/336 (67%), Gaps = 13/336 (3%)
Query: 5 SGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLY 64
S S L+VG +++ +KIG G+FG++ LG E VA+KLE K + PQL E + Y
Sbjct: 31 SSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFY 90
Query: 65 TILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRI 124
L G GIP ++++G N +V++LLGPSLEDLF+ C R F++KTVLM+A Q+ISR+
Sbjct: 91 KQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRM 150
Query: 125 EYVHTKNFLHRDIKPDNFLMGTGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYREDKH 180
EYVH+KN ++RD+KP+NFL+ GR NK + +IDFGLAK+Y D T++HIPYRE K
Sbjct: 151 EYVHSKNLIYRDVKPENFLI--GRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKS 208
Query: 181 LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKK 240
L GT RY SIN HLG EQSRRDD+E+LG++FMYF R SLPWQGLKA T K++Y+KI + K
Sbjct: 209 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 268
Query: 241 MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM 300
+TP+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF + +DY +DW +
Sbjct: 269 RATPIEVLCENFP-EMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDW-I 326
Query: 301 LKQ-----KAAQQAASSSGQGQQAQTQTGKQTEKNK 331
KQ A QQ + S + Q + Q KN+
Sbjct: 327 GKQLPTPVGAVQQDPALSSNREAHQHRDKMQQSKNQ 362
>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
Length = 422
Score = 319 bits (817), Expect = 3e-87
Identities = 160/302 (52%), Positives = 212/302 (70%), Gaps = 7/302 (2%)
Query: 2 TNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYES 61
+ +S S L+VG +++ +KIG G+FG++ LG E VA+KLE K + PQL E
Sbjct: 29 SGSSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEY 88
Query: 62 KLYTIL-QGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM 120
+ Y L G G+P ++++G N +V++LLGPSLEDLF+ C R FT+KTVLM+A Q+
Sbjct: 89 RFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQL 148
Query: 121 ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNK----LFLIDFGLAKKYRDNRTRQHIPYR 176
+SR+EYVH+KN ++RD+KP+NFL+G R NK + +IDFGLAK+Y D T++HIPYR
Sbjct: 149 LSRMEYVHSKNLIYRDVKPENFLIG--RQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYR 206
Query: 177 EDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKI 236
E K L GT RY SIN HLG EQSRRDD+E+LG++FMYF R SLPWQGLKA T K++Y+KI
Sbjct: 207 EHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKI 266
Query: 237 SEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTF 296
+ K +TP+E LC+ FP E A YL Y R L F E PDY YLR LF LF + +DY +
Sbjct: 267 GDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAY 326
Query: 297 DW 298
DW
Sbjct: 327 DW 328
>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
Length = 415
Score = 316 bits (810), Expect = 2e-86
Identities = 156/294 (53%), Positives = 208/294 (70%), Gaps = 2/294 (0%)
Query: 7 SKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTI 66
S L+VG +++ +KIG G+FG++ LG E VA+KLE K + PQL E + Y
Sbjct: 36 SSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQ 95
Query: 67 LQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEY 126
L G+P ++++G N +V++LLGPSLEDLF+ C R FT+KTVLM+A Q+I+R+EY
Sbjct: 96 LSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEY 155
Query: 127 VHTKNFLHRDIKPDNFLMGTG--RHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGT 184
VHTK+ ++RD+KP+NFL+G + + + +IDFGLAK+Y D T++HIPYRE K L GT
Sbjct: 156 VHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 215
Query: 185 VRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTP 244
RY SIN HLG EQSRRDD+E+LG++FMYF R SLPWQGLKA T K++Y+KI + K +TP
Sbjct: 216 ARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATP 275
Query: 245 VEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDW 298
+EVLC+ FP E A YL Y R L F E PDY YLR+LF LF +DY +DW
Sbjct: 276 IEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDW 329
>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
Length = 1321
Score = 161 bits (407), Expect = 9e-40
Identities = 112/324 (34%), Positives = 160/324 (49%), Gaps = 27/324 (8%)
Query: 9 AELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQ 68
A VV ++K+++KIG G FG++Y + E VA+K+ES + L E + LQ
Sbjct: 26 ANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQ 85
Query: 69 GGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYV 127
G + G+ + N +VM L G +L DL R FT+ T L L Q++ IE +
Sbjct: 86 GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAI 145
Query: 128 HTKNFLHRDIKPDNFLMG----TGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIG 183
H+ FLHRDIKP NF MG T R C +++DFGLA++Y N T P R G
Sbjct: 146 HSVGFLHRDIKPSNFAMGRLPSTYRKC---YMLDFGLARQYT-NTTGDVRPPRNVAGFRG 201
Query: 184 TVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTK----KQKYEKISEK 239
TVRYAS+NAH E R DD+ SL Y+ + F LPW+ +K + K+KYE
Sbjct: 202 TVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEH---- 257
Query: 240 KMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWT 299
+L K P+EF ++L++ L + PDY + +F + + FDW
Sbjct: 258 ------RMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDW- 310
Query: 300 MLKQKAAQQAASSSGQGQQAQTQT 323
+KA A S+ Q T
Sbjct: 311 ---EKAGTDALLSTSTSTPPQQNT 331
>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
Length = 1244
Score = 157 bits (396), Expect = 2e-38
Identities = 103/290 (35%), Positives = 148/290 (51%), Gaps = 9/290 (3%)
Query: 11 LVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQGG 70
++V ++K++RKIG G FG++Y + E VA+K+ES + L E + LQG
Sbjct: 15 ILVKERWKVLRKIGGGGFGEIYDALDMLTRENVALKVESAQQPKQVLKMEVAVLKKLQGK 74
Query: 71 VGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSR-RFTMKTVLMLADQMISRIEYVHT 129
+ G+ N +VM L G +L DL SR FT+ T L L Q++ IE +H+
Sbjct: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134
Query: 130 KNFLHRDIKPDNFLMGT-GRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYA 188
FLHRDIKP NF MG C K +++DFGLA+++ N P R GTVRYA
Sbjct: 135 VGFLHRDIKPSNFAMGRFPSTCRKCYMLDFGLARQF-TNSCGDVRPPRAVAGFRGTVRYA 193
Query: 189 SINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVL 248
SINAH E R DD+ SL Y+ + F LPW+ +K E++ K ++
Sbjct: 194 SINAHRNREMGRHDDLWSLFYMLVEFVVGQLPWRKIK------DKEQVGSIKERYDHRLM 247
Query: 249 CKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDW 298
K P EF+++L++ L + PDY L +F +T FDW
Sbjct: 248 LKHLPPEFSIFLDHISSLDYFTKPDYQLLTSVFDNSIKTFGVIESDPFDW 297
>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
Length = 396
Score = 111 bits (277), Expect = 1e-24
Identities = 90/351 (25%), Positives = 160/351 (45%), Gaps = 41/351 (11%)
Query: 16 KYKLVRKIGSGSFGDVYLGITTTN---GEEVAVKLESQKVKHPQLLYESKLY-------- 64
++K+ IG G FG +YL ++ G + ++ + + L E K Y
Sbjct: 36 EWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQ 95
Query: 65 ------TILQGGVGIPHMHWYGQEKDNN-----VLVMDLLGPSLEDLFNFCSRRFTMKTV 113
T +G+P +W D N ++MD G L+ ++ ++RF+ KTV
Sbjct: 96 IQKWIRTRKLKYLGVPK-YWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTV 154
Query: 114 LMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHI 173
L L+ +++ +EY+H ++H DIK N L+ ++ ++++L+D+GLA +Y H
Sbjct: 155 LQLSLRILDILEYIHEHEYVHGDIKASNLLLNY-KNPDQVYLVDYGLAYRYCPEGV--HK 211
Query: 174 PYREDKHLI--GTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQ 231
Y+ED GT+ + SI+AH G+ SRR D+E LGY + + LPW+ K
Sbjct: 212 EYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYV 271
Query: 232 KYEKISEKKMSTPVEVLC---KGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTL 288
+ KI ++ + C K P E A Y+ + L + E P Y LR + + +
Sbjct: 272 RDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQGLKAI 331
Query: 289 NHQYDYTFDWTMLK----------QKAAQQAASSSGQGQQAQTQTGKQTEK 329
+ D D ++++ +K ++ S G + + QTE+
Sbjct: 332 GSKDDGKLDLSVVENGGLKAKTITKKRKKEIEESKEPGVEDTEWSNTQTEE 382
>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
Length = 396
Score = 106 bits (264), Expect = 3e-23
Identities = 85/291 (29%), Positives = 137/291 (47%), Gaps = 28/291 (9%)
Query: 14 GGKYKLVRKIGSGSFGDVYLGITTTNGEEVA---VKLESQKVKHPQLLYESKLYTILQGG 70
G ++ L +KIGSG FG +YL T E+ A VK+E Q+ + L E K Y +
Sbjct: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 83
Query: 71 --------------VGIPHMHWYG----QEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+GIP + G + + +VM+ LG L+ + + F T
Sbjct: 84 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 142
Query: 113 VLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH 172
VL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y N +
Sbjct: 143 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 201
Query: 173 IPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW-QGLK--AMTK 229
K GT+ + S++AH G+ SRR D+E LGY + + LPW Q LK +
Sbjct: 202 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 261
Query: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQL 280
K + E S E A +L L ++E P+Y L+++
Sbjct: 262 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
Length = 485
Score = 106 bits (264), Expect = 3e-23
Identities = 85/291 (29%), Positives = 137/291 (47%), Gaps = 28/291 (9%)
Query: 14 GGKYKLVRKIGSGSFGDVYLGITTTNGEEVA---VKLESQKVKHPQLLYESKLYTILQGG 70
G ++ L +KIGSG FG +YL T E+ A VK+E Q+ + L E K Y +
Sbjct: 3 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 60
Query: 71 --------------VGIPHMHWYG----QEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+GIP + G + + +VM+ LG L+ + + F T
Sbjct: 61 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 119
Query: 113 VLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH 172
VL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y N +
Sbjct: 120 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 178
Query: 173 IPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW-QGLK--AMTK 229
K GT+ + S++AH G+ SRR D+E LGY + + LPW Q LK +
Sbjct: 179 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 238
Query: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQL 280
K + E S E A +L L ++E P+Y L+++
Sbjct: 239 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 289
>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 106 bits (264), Expect = 3e-23
Identities = 85/291 (29%), Positives = 137/291 (47%), Gaps = 28/291 (9%)
Query: 14 GGKYKLVRKIGSGSFGDVYLGITTTNGEEVA---VKLESQKVKHPQLLYESKLYTILQGG 70
G ++ L +KIGSG FG +YL T E+ A VK+E Q+ + L E K Y +
Sbjct: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 83
Query: 71 --------------VGIPHMHWYG----QEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+GIP + G + + +VM+ LG L+ + + F T
Sbjct: 84 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 142
Query: 113 VLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH 172
VL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y N +
Sbjct: 143 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 201
Query: 173 IPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW-QGLK--AMTK 229
K GT+ + S++AH G+ SRR D+E LGY + + LPW Q LK +
Sbjct: 202 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 261
Query: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQL 280
K + E S E A +L L ++E P+Y L+++
Sbjct: 262 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 106 bits (264), Expect = 3e-23
Identities = 85/291 (29%), Positives = 137/291 (47%), Gaps = 28/291 (9%)
Query: 14 GGKYKLVRKIGSGSFGDVYLGITTTNGEEVA---VKLESQKVKHPQLLYESKLYTILQGG 70
G ++ L +KIGSG FG +YL T E+ A VK+E Q+ + L E K Y +
Sbjct: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 83
Query: 71 --------------VGIPHMHWYG----QEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+GIP + G + + +VM+ LG L+ + + F T
Sbjct: 84 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 142
Query: 113 VLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH 172
VL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y N +
Sbjct: 143 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 201
Query: 173 IPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW-QGLK--AMTK 229
K GT+ + S++AH G+ SRR D+E LGY + + LPW Q LK +
Sbjct: 202 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 261
Query: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQL 280
K + E S E A +L L ++E P+Y L+++
Sbjct: 262 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
Length = 508
Score = 106 bits (264), Expect = 3e-23
Identities = 85/291 (29%), Positives = 137/291 (47%), Gaps = 28/291 (9%)
Query: 14 GGKYKLVRKIGSGSFGDVYLGITTTNGEEVA---VKLESQKVKHPQLLYESKLYTILQGG 70
G ++ L +KIGSG FG +YL T E+ A VK+E Q+ + L E K Y +
Sbjct: 26 GNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQE--NGPLFSELKFYQRVAKK 83
Query: 71 --------------VGIPHMHWYG----QEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKT 112
+GIP + G + + +VM+ LG L+ + + F T
Sbjct: 84 DCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLGIDLQKISGQ-NGTFKKST 142
Query: 113 VLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH 172
VL L +M+ +EY+H ++H DIK N L+G ++ ++++L D+GL+ +Y N +
Sbjct: 143 VLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY-KNPDQVYLADYGLSYRYCPNGNHKQ 201
Query: 173 IPYREDKHLIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPW-QGLK--AMTK 229
K GT+ + S++AH G+ SRR D+E LGY + + LPW Q LK +
Sbjct: 202 YQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQ 261
Query: 230 KQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQL 280
K + E S E A +L L ++E P+Y L+++
Sbjct: 262 TAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 312
>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
Length = 390
Score = 90.1 bits (222), Expect = 2e-18
Identities = 59/196 (30%), Positives = 98/196 (50%), Gaps = 5/196 (2%)
Query: 88 LVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTG 147
+VM+ LG L+ + + F TVL L +M+ +EY+H ++H DIK N L+G
Sbjct: 1 MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
Query: 148 RHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGIEQSRRDDMESL 207
++ ++++L D+GL+ +Y N + K GT+ + S++AH G+ SRR D+E L
Sbjct: 59 KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
Query: 208 GYVFMYFNRTSLPW-QGLK--AMTKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCR 264
GY + + LPW Q LK + K + E S E A +L
Sbjct: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
Query: 265 GLRFEEVPDYMYLRQL 280
L ++E P+Y L+++
Sbjct: 179 SLAYDEKPNYQALKKI 194
>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
Length = 424
Score = 66.6 bits (161), Expect = 3e-11
Identities = 56/225 (24%), Positives = 101/225 (44%), Gaps = 10/225 (4%)
Query: 71 VGIPHMHWYGQEKDN-NVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
+ IP +G +D LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 189 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 248
Query: 129 TKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLI--GTVR 186
++H ++ +N + +++ L +G A +Y + +H+ Y E G +
Sbjct: 249 ENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 305
Query: 187 YASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVE 246
+ S++ H G SRR D++SLGY + + LPW T+ +K P
Sbjct: 306 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 365
Query: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTL 288
C + P+E YL L +EE P Y LR L + L
Sbjct: 366 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 410
>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
Length = 474
Score = 66.6 bits (161), Expect = 3e-11
Identities = 56/225 (24%), Positives = 101/225 (44%), Gaps = 10/225 (4%)
Query: 71 VGIPHMHWYGQEKDN-NVLVMDLLGPSLEDLFNFCSRR-FTMKTVLMLADQMISRIEYVH 128
+ IP +G +D LV+ LG SL+ + + + ++VL +A +++ +E++H
Sbjct: 239 LAIPTCMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLH 298
Query: 129 TKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLI--GTVR 186
++H ++ +N + +++ L +G A +Y + +H+ Y E G +
Sbjct: 299 ENEYVHGNVTAENIFVDPEDQ-SQVTLAGYGFAFRYCPSG--KHVAYVEGSRSPHEGDLE 355
Query: 187 YASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVE 246
+ S++ H G SRR D++SLGY + + LPW T+ +K P
Sbjct: 356 FISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFV 415
Query: 247 VLCKGF--PAE-FAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTL 288
C + P+E YL L +EE P Y LR L + L
Sbjct: 416 GPCGHWIRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDL 460
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 65.5 bits (158), Expect = 7e-11
Identities = 66/242 (27%), Positives = 108/242 (44%), Gaps = 37/242 (15%)
Query: 17 YKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQGGVGIPHM 76
Y+L IG+G F V L GE VA+K+ + L ++ T ++ + H
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDL---PRIKTEIEALKNLRHQ 67
Query: 77 H----WYGQEKDNNVLVMDLLGPSLEDLFNFC--SRRFTMKTVLMLADQMISRIEYVHTK 130
H ++ E N + ++ P E LF++ R + + ++ Q++S + YVH++
Sbjct: 68 HICQLYHVLETANKIFMVLEYCPGGE-LFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQ 126
Query: 131 NFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHL---IGTVRY 187
+ HRD+KP+N L +KL LIDFGL K + N+ D HL G++ Y
Sbjct: 127 GYAHRDLKPENLLFD---EYHKLKLIDFGLCAKPKGNK---------DYHLQTCCGSLAY 174
Query: 188 ASI-----NAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMS 242
A+ ++LG E D+ S+G + LP+ M Y+KI K
Sbjct: 175 AAPELIQGKSYLGSEA----DVWSMGILLYVLMCGFLPFDDDNVMA---LYKKIMRGKYD 227
Query: 243 TP 244
P
Sbjct: 228 VP 229
>gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]
Length = 350
Score = 65.1 bits (157), Expect = 9e-11
Identities = 46/156 (29%), Positives = 77/156 (49%), Gaps = 20/156 (12%)
Query: 17 YKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQGGVGIPHM 76
Y+LVRK+G G + +V+ I TN E V VK+ + VK ++ E K+ L+GG I +
Sbjct: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKI-LKPVKKKKIKREVKILENLRGGTNIIKL 98
Query: 77 HWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLAD--------QMISRIEYVH 128
V D + + +F + + + +L D +++ ++Y H
Sbjct: 99 ---------IDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCH 149
Query: 129 TKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKY 164
+K +HRD+KP N ++ KL LID+GLA+ Y
Sbjct: 150 SKGIMHRDVKPHNVMI--DHQQKKLRLIDWGLAEFY 183
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 65.1 bits (157), Expect = 9e-11
Identities = 54/199 (27%), Positives = 90/199 (45%), Gaps = 13/199 (6%)
Query: 17 YKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKLYTILQG--GVGIP 74
Y + K+G GS+ VY GI+ NG+ VA+K+ S + + ++L+G I
Sbjct: 52 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIV 111
Query: 75 HMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLH 134
+H K+ V + + L + V + Q++ + Y+H ++ LH
Sbjct: 112 LLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
Query: 135 RDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHL 194
RD+KP N L+ H +L L DFGLA+ + IP + + T+ Y +A L
Sbjct: 172 RDLKPQNLLIS---HLGELKLADFGLAR-------AKSIPSQTYSSEVVTLWYRPPDALL 221
Query: 195 G-IEQSRRDDMESLGYVFM 212
G E S D+ G +F+
Sbjct: 222 GATEYSSELDIWGAGCIFI 240
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 64.7 bits (156), Expect = 1e-10
Identities = 55/197 (27%), Positives = 89/197 (45%), Gaps = 34/197 (17%)
Query: 16 KYKLVRKIGSGSFGDVYLGITTTNGEEVAVK---LESQKVKHP-----------QLLYES 61
K+ ++ IG G++G VY GE VA+K L+++K P QL++ S
Sbjct: 726 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRS 785
Query: 62 -----KLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLML 116
++ T Q + + ++K LV + + L L F+ +
Sbjct: 786 VVNMKEIVTDKQDALD------FKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSF 839
Query: 117 ADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH---- 172
Q++ +EY H KNFLHRDIK N L+ + ++ L DFGLA+ Y +R +
Sbjct: 840 MKQLMEGLEYCHKKNFLHRDIKCSNILL---NNSGQIKLADFGLARLYNSEESRPYTNKV 896
Query: 173 --IPYREDKHLIGTVRY 187
+ YR + L+G RY
Sbjct: 897 ITLWYRPPELLLGEERY 913
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 64.7 bits (156), Expect = 1e-10
Identities = 55/197 (27%), Positives = 89/197 (45%), Gaps = 34/197 (17%)
Query: 16 KYKLVRKIGSGSFGDVYLGITTTNGEEVAVK---LESQKVKHP-----------QLLYES 61
K+ ++ IG G++G VY GE VA+K L+++K P QL++ S
Sbjct: 726 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRS 785
Query: 62 -----KLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLML 116
++ T Q + + ++K LV + + L L F+ +
Sbjct: 786 VVNMKEIVTDKQDALD------FKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSF 839
Query: 117 ADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQH---- 172
Q++ +EY H KNFLHRDIK N L+ + ++ L DFGLA+ Y +R +
Sbjct: 840 MKQLMEGLEYCHKKNFLHRDIKCSNILL---NNSGQIKLADFGLARLYNSEESRPYTNKV 896
Query: 173 --IPYREDKHLIGTVRY 187
+ YR + L+G RY
Sbjct: 897 ITLWYRPPELLLGEERY 913
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 63.2 bits (152), Expect = 3e-10
Identities = 59/197 (29%), Positives = 94/197 (47%), Gaps = 17/197 (8%)
Query: 23 IGSGSFGDVYLGITTTNGEEVAVKLESQKVKHPQLLYESKL---YTILQG--GVGIPHMH 77
+GSG FG VY G G +VAVK+ K++ P ES+L ILQ GI ++
Sbjct: 400 LGSGQFGVVYGGKHRKTGRDVAVKV-IDKLRFPTK-QESQLRNEVAILQSLRHPGIVNLE 457
Query: 78 WYGQEKDNNVLVMDLL-GPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRD 136
+ + +VM+ L G LE + + R + L Q++ + ++H KN +H D
Sbjct: 458 CMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCD 517
Query: 137 IKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGI 196
+KP+N L+ + ++ L DFG A+ + R+ + +GT Y + L
Sbjct: 518 LKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSV--------VGTPAYLAPEVLLNQ 569
Query: 197 EQSRRDDMESLGYVFMY 213
+R DM S+G V MY
Sbjct: 570 GYNRSLDMWSVG-VIMY 585
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,814,831
Number of Sequences: 37866
Number of extensions: 495925
Number of successful extensions: 2351
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 498
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 1272
Number of HSP's gapped (non-prelim): 833
length of query: 337
length of database: 18,247,518
effective HSP length: 103
effective length of query: 234
effective length of database: 14,347,320
effective search space: 3357272880
effective search space used: 3357272880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.