Search of human proteins with 21493045

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21493045 A-kinase anchor protein 6 [Homo sapiens]
         (2319 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21493045 A-kinase anchor protein 6 [Homo sapiens]                 4610   0.0  
gi|154277118 spectrin repeat containing, nuclear envelope 1 isof...    91   1e-17
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo...    91   1e-17
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof...    91   1e-17
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    84   1e-15
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof...    79   5e-14
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof...    79   5e-14
gi|154800457 centrosomal protein 68kDa [Homo sapiens]                  74   2e-12
gi|154277120 spectrin repeat containing, nuclear envelope 1 isof...    64   2e-09
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    59   7e-08
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    58   9e-08
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    54   1e-06
gi|33188443 microfilament and actin filament cross-linker protei...    54   1e-06
gi|33188445 microfilament and actin filament cross-linker protei...    54   1e-06
gi|67782321 spectrin beta isoform a [Homo sapiens]                     54   2e-06
gi|67782319 spectrin beta isoform b [Homo sapiens]                     54   2e-06
gi|221316624 dystonin isoform 4 [Homo sapiens]                         52   5e-06
gi|221316622 dystonin isoform 3 [Homo sapiens]                         52   5e-06
gi|221316618 dystonin isoform 2 [Homo sapiens]                         52   5e-06
gi|34577047 dystonin isoform 1 [Homo sapiens]                          52   5e-06
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]              52   5e-06
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     52   7e-06
gi|71061468 centromere protein E [Homo sapiens]                        49   4e-05
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]                     47   2e-04
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]                     47   2e-04
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  47   2e-04
gi|110611228 utrophin [Homo sapiens]                                   47   3e-04
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...    46   5e-04
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...    45   8e-04
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...    45   8e-04

>gi|21493045 A-kinase anchor protein 6 [Homo sapiens]
          Length = 2319

 Score = 4610 bits (11957), Expect = 0.0
 Identities = 2319/2319 (100%), Positives = 2319/2319 (100%)

Query: 1    MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHT 60
            MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHT
Sbjct: 1    MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHT 60

Query: 61   GADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQ 120
            GADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQ
Sbjct: 61   GADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQ 120

Query: 121  IHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT 180
            IHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT
Sbjct: 121  IHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQT 180

Query: 181  DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGL 240
            DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGL
Sbjct: 181  DILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGL 240

Query: 241  GDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTNGSEAVTEEVSQVSLS 300
            GDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTNGSEAVTEEVSQVSLS
Sbjct: 241  GDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTNGSEAVTEEVSQVSLS 300

Query: 301  VDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ 360
            VDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ
Sbjct: 301  VDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQ 360

Query: 361  PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPE 420
            PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPE
Sbjct: 361  PVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPE 420

Query: 421  MSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGNGNLENTVKFHIKEISS 480
            MSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGNGNLENTVKFHIKEISS
Sbjct: 421  MSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGNGNLENTVKFHIKEISS 480

Query: 481  SLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA 540
            SLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA
Sbjct: 481  SLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKA 540

Query: 541  IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSK 600
            IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSK
Sbjct: 541  IEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSK 600

Query: 601  HKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRG 660
            HKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRG
Sbjct: 601  HKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRG 660

Query: 661  ETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI 720
            ETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI
Sbjct: 661  ETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDI 720

Query: 721  LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEK 780
            LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEK
Sbjct: 721  LSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEK 780

Query: 781  IEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVE 840
            IEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVE
Sbjct: 781  IEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVE 840

Query: 841  EEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV 900
            EEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV
Sbjct: 841  EEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSV 900

Query: 901  EDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNG 960
            EDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNG
Sbjct: 901  EDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNG 960

Query: 961  LLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKV 1020
            LLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKV
Sbjct: 961  LLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKV 1020

Query: 1021 EALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLV 1080
            EALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLV
Sbjct: 1021 EALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLV 1080

Query: 1081 RQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASI 1140
            RQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASI
Sbjct: 1081 RQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASI 1140

Query: 1141 LRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLN 1200
            LRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLN
Sbjct: 1141 LRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLN 1200

Query: 1201 VIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPG 1260
            VIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPG
Sbjct: 1201 VIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPG 1260

Query: 1261 YDEEADNHGGSQYASNITAPSSPHIYQVYSLHNVELYEDNHMPFLKNNPKVTGMTQPNVL 1320
            YDEEADNHGGSQYASNITAPSSPHIYQVYSLHNVELYEDNHMPFLKNNPKVTGMTQPNVL
Sbjct: 1261 YDEEADNHGGSQYASNITAPSSPHIYQVYSLHNVELYEDNHMPFLKNNPKVTGMTQPNVL 1320

Query: 1321 TKSLSKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNSGSESGIVSEGDTETTTNSEM 1380
            TKSLSKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNSGSESGIVSEGDTETTTNSEM
Sbjct: 1321 TKSLSKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNSGSESGIVSEGDTETTTNSEM 1380

Query: 1381 CLLNAVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKV 1440
            CLLNAVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKV
Sbjct: 1381 CLLNAVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKV 1440

Query: 1441 GDLNSITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLR 1500
            GDLNSITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLR
Sbjct: 1441 GDLNSITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLR 1500

Query: 1501 GFYFDKKSCKSKHQTTELQPDVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLS 1560
            GFYFDKKSCKSKHQTTELQPDVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLS
Sbjct: 1501 GFYFDKKSCKSKHQTTELQPDVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLS 1560

Query: 1561 LLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISV 1620
            LLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISV
Sbjct: 1561 LLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISV 1620

Query: 1621 SSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSI 1680
            SSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSI
Sbjct: 1621 SSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSI 1680

Query: 1681 NEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNV 1740
            NEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNV
Sbjct: 1681 NEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNV 1740

Query: 1741 SCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKN 1800
            SCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKN
Sbjct: 1741 SCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKN 1800

Query: 1801 ELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPSDTLNIETLLNGSVKRVSENN 1860
            ELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPSDTLNIETLLNGSVKRVSENN
Sbjct: 1801 ELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPSDTLNIETLLNGSVKRVSENN 1860

Query: 1861 GNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENL 1920
            GNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENL
Sbjct: 1861 GNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENL 1920

Query: 1921 GSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPT 1980
            GSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPT
Sbjct: 1921 GSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPT 1980

Query: 1981 EKSFSELALETRFNNRQDSDALKSSDDAPSMAGKSAGCCLALEQNGTEENASISNISCCN 2040
            EKSFSELALETRFNNRQDSDALKSSDDAPSMAGKSAGCCLALEQNGTEENASISNISCCN
Sbjct: 1981 EKSFSELALETRFNNRQDSDALKSSDDAPSMAGKSAGCCLALEQNGTEENASISNISCCN 2040

Query: 2041 CEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENEVAAPTSLTQIKEKVLEHSHR 2100
            CEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENEVAAPTSLTQIKEKVLEHSHR
Sbjct: 2041 CEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENEVAAPTSLTQIKEKVLEHSHR 2100

Query: 2101 PIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACV 2160
            PIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACV
Sbjct: 2101 PIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACV 2160

Query: 2161 EGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQE 2220
            EGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQE
Sbjct: 2161 EGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQE 2220

Query: 2221 RAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDL 2280
            RAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDL
Sbjct: 2221 RAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDL 2280

Query: 2281 SLKANQPTDKAALHPSPKTLTCEENLLNLHEKRHRNMHR 2319
            SLKANQPTDKAALHPSPKTLTCEENLLNLHEKRHRNMHR
Sbjct: 2281 SLKANQPTDKAALHPSPKTLTCEENLLNLHEKRHRNMHR 2319


>gi|154277118 spectrin repeat containing, nuclear envelope 1 isoform 4
            [Homo sapiens]
          Length = 3321

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 77/310 (24%), Positives = 143/310 (46%), Gaps = 55/310 (17%)

Query: 887  DTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEE 946
            DT+ A I A D+S+ +E      +   +LC+         Q+SL            R+++
Sbjct: 2260 DTLSAYISADDISILNERVELLQRQWEELCH---------QLSL------------RRQQ 2298

Query: 947  FADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEM 1006
              +     +V       F  + +EL +WL  MES V  + D+++ EE  + L K Y  E+
Sbjct: 2299 IGERLNEWAV-------FSEKNKELCEWLTQMESKVSQNGDILI-EEMIEKLKKDYQEEI 2350

Query: 1007 SIRHLKKTELLSKVEALKKGGVLLPNDLLE-KVDSINEKWELLGKTLGEKIQDTMAGHSG 1065
            +I    K +L    E L K         +E K+  +N++W+ L   +  +++        
Sbjct: 2351 AIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK----- 2405

Query: 1066 SSPRDLLSPESGSLVRQLEVRIKELKGWLRDTEL-----FIFNSCLRQEKEGTMNTEKQL 1120
                     E+   V+QL+  +  L+ WL   E       +++SC  +E +  +N +++L
Sbjct: 2406 ---------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 2456

Query: 1121 QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQ 1180
            Q      R+I++   GVAS+L LC+ LL D + C  +A+   +Q    NL+RRW  I   
Sbjct: 2457 Q------RDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 2510

Query: 1181 AVQWQTRLQK 1190
            +++ + ++++
Sbjct: 2511 SMERRLKIEE 2520



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 94/399 (23%), Positives = 157/399 (39%), Gaps = 65/399 (16%)

Query: 790  EFIQWLNEAMETTENWTPPKA----EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQ 845
            + I WL  A +  E WT        E++ ++ +L   L F   VD+  +LK +V   G+Q
Sbjct: 1330 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 1389

Query: 846  LLELIASHKAGLKDMLRMIASQWKELQRQI----KRQHSWILRALDTIKA--EI-----L 894
            LL L     A L+  L  I SQW +L   I    ++ H   +  L +  A  E+     L
Sbjct: 1390 LLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISL 1449

Query: 895  ATDVSVEDEEGTGSP---KA-----------EVQLCYLEAQRDAVEQMSLKLYSEQYTSS 940
              +V  +DE+   +    KA           ++ +   +   D V Q  L++ S+   S 
Sbjct: 1450 MENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK 1509

Query: 941  SKRKEEFAD----MSKVHSVGS----------NGLLDFDSEYQE----LWDWLIDMESLV 982
               K +FA+    M+K   +             GLL+  SEY+     L  W    E  +
Sbjct: 1510 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRL 1569

Query: 983  MDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSI- 1041
               H +      Q  L     +E  I+  +K     +VE +++ G+ L  +  E V SI 
Sbjct: 1570 KQQHRIGDQASVQNALKDCQDLEDLIKAKEK-----EVEKIEQNGLALIQNKKEDVSSIV 1624

Query: 1042 -------NEKWELLGKTLGE-KIQDTMAGHSGSSPRDLLSPESGSLV--RQLEVRIKELK 1091
                    + W  L   +G+ KI         SS +      +  L+  R    R + L 
Sbjct: 1625 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 1684

Query: 1092 GWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREI 1130
            G L   ++ + N  L+  ++     E+ LQ F S+  ++
Sbjct: 1685 GSLEAVQVQVDN--LQNLQDDLEKQERSLQKFGSITNQL 1721


>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform 2
            [Homo sapiens]
          Length = 8749

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 77/310 (24%), Positives = 143/310 (46%), Gaps = 55/310 (17%)

Query: 887  DTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEE 946
            DT+ A I A D+S+ +E      +   +LC+         Q+SL            R+++
Sbjct: 7665 DTLSAYISADDISILNERVELLQRQWEELCH---------QLSL------------RRQQ 7703

Query: 947  FADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEM 1006
              +     +V       F  + +EL +WL  MES V  + D+++ EE  + L K Y  E+
Sbjct: 7704 IGERLNEWAV-------FSEKNKELCEWLTQMESKVSQNGDILI-EEMIEKLKKDYQEEI 7755

Query: 1007 SIRHLKKTELLSKVEALKKGGVLLPNDLLE-KVDSINEKWELLGKTLGEKIQDTMAGHSG 1065
            +I    K +L    E L K         +E K+  +N++W+ L   +  +++        
Sbjct: 7756 AIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK----- 7810

Query: 1066 SSPRDLLSPESGSLVRQLEVRIKELKGWLRDTEL-----FIFNSCLRQEKEGTMNTEKQL 1120
                     E+   V+QL+  +  L+ WL   E       +++SC  +E +  +N +++L
Sbjct: 7811 ---------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7861

Query: 1121 QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQ 1180
            Q      R+I++   GVAS+L LC+ LL D + C  +A+   +Q    NL+RRW  I   
Sbjct: 7862 Q------RDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 7915

Query: 1181 AVQWQTRLQK 1190
            +++ + ++++
Sbjct: 7916 SMERRLKIEE 7925



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 94/399 (23%), Positives = 157/399 (39%), Gaps = 65/399 (16%)

Query: 790  EFIQWLNEAMETTENWTPPKA----EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQ 845
            + I WL  A +  E WT        E++ ++ +L   L F   VD+  +LK +V   G+Q
Sbjct: 6735 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6794

Query: 846  LLELIASHKAGLKDMLRMIASQWKELQRQI----KRQHSWILRALDTIKA--EI-----L 894
            LL L     A L+  L  I SQW +L   I    ++ H   +  L +  A  E+     L
Sbjct: 6795 LLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISL 6854

Query: 895  ATDVSVEDEEGTGSP---KA-----------EVQLCYLEAQRDAVEQMSLKLYSEQYTSS 940
              +V  +DE+   +    KA           ++ +   +   D V Q  L++ S+   S 
Sbjct: 6855 MENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK 6914

Query: 941  SKRKEEFAD----MSKVHSVGS----------NGLLDFDSEYQE----LWDWLIDMESLV 982
               K +FA+    M+K   +             GLL+  SEY+     L  W    E  +
Sbjct: 6915 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRL 6974

Query: 983  MDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSI- 1041
               H +      Q  L     +E  I+  +K     +VE +++ G+ L  +  E V SI 
Sbjct: 6975 KQQHRIGDQASVQNALKDCQDLEDLIKAKEK-----EVEKIEQNGLALIQNKKEDVSSIV 7029

Query: 1042 -------NEKWELLGKTLGE-KIQDTMAGHSGSSPRDLLSPESGSLV--RQLEVRIKELK 1091
                    + W  L   +G+ KI         SS +      +  L+  R    R + L 
Sbjct: 7030 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 7089

Query: 1092 GWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREI 1130
            G L   ++ + N  L+  ++     E+ LQ F S+  ++
Sbjct: 7090 GSLEAVQVQVDN--LQNLQDDLEKQERSLQKFGSITNQL 7126



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 57/220 (25%), Positives = 99/220 (45%), Gaps = 24/220 (10%)

Query: 661  ETIQNIDDWELSEMNSDSEIYPTYHVKKKH--TRLGRVSPSSSSDIASSLGESIESGPLS 718
            E IQ++++ E S ++S S+ Y + H   K+  T++ +V           +G+ +++  L 
Sbjct: 3687 EEIQSLEESE-SSLSSYSDWYGSTHKNFKNVATKIDKVD-------TVMMGKKLKT--LE 3736

Query: 719  DILSDEESSMPLAGMKKYADEKSERASSS-EKNESHSATKSA-----LIQKLMQDIQHQD 772
             +L D E    L    K A EK ERA    E+ E+    K        +++L   ++ + 
Sbjct: 3737 VLLKDMEKGHSLL---KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEH 3793

Query: 773  -NYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDS 831
               E      + F +K     QW+ E  E       PK E+ + K  L  + S +  V S
Sbjct: 3794 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLS 3853

Query: 832  HCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKEL 871
            H    ++V E+G  LLEL+      LKD +  + S +++L
Sbjct: 3854 HEPSVKSVREKGEALLELV--QDVTLKDKIDQLQSDYQDL 3891



 Score = 36.6 bits (83), Expect = 0.30
 Identities = 78/367 (21%), Positives = 140/367 (38%), Gaps = 65/367 (17%)

Query: 638  KQTEVLALKLENLTKLLPQKPRG---------------ETIQNIDDWELSEMNSDSEIYP 682
            K+TE +A++ ENL K   + P G               E ++ ++D  L E     E+  
Sbjct: 1394 KRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED-TLEEDIKTMEMVK 1452

Query: 683  T-------------YHVKKKHTRLGRVSPSSS------SDIASSLGESIESGPLSDILSD 723
            T               + +K   L  +  SSS      S I  ++ E IES  LS I+  
Sbjct: 1453 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQE-IES-KLSSIVGL 1510

Query: 724  EESSMPLAGMKKYADEKSERAS-------SSEKNESHSATKSALIQKLMQDIQHQDNYEA 776
            EE +   A      +    +A          E  E     +  ++  L Q  + ++N   
Sbjct: 1511 EEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1570

Query: 777  IWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFK------LNVD 830
            I + +  F +KL   I+  + A ET +           L+       +F       +N D
Sbjct: 1571 IQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRD 1630

Query: 831  SHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIK 890
            S      A++++   +L      +  L+++L    + W+ L++++    +W+ R     K
Sbjct: 1631 SCVQEAAALQQQYEDILRRAKERQTALENLL----AHWQRLEKELSSFLTWLERG--EAK 1684

Query: 891  AEILATDVSVEDEEGTGSPKAEVQLCYLEA-QRDAVEQMSL--KLYSEQYTSSSKRKEEF 947
            A     D+S +        K E +L  ++A Q + V Q S   KL   + +  S   ++ 
Sbjct: 1685 ASSPEMDISAD------RVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDD 1738

Query: 948  ADMSKVH 954
              M K+H
Sbjct: 1739 VKMMKLH 1745



 Score = 36.2 bits (82), Expect = 0.39
 Identities = 98/447 (21%), Positives = 186/447 (41%), Gaps = 62/447 (13%)

Query: 670  ELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDILSDEESSMP 729
            E+ E+ +D+E        KK +    +  SSS +    L E      +S + S  E  + 
Sbjct: 5041 EVIELMNDTE--------KKLSEFSLLKTSSSHEAEEKLSE--HKALVSVVNSFHEKIVA 5090

Query: 730  LAGMKKYADEKSERASSSEK--NESHSATKSALIQKLMQDIQH-----QDNYEAIWEKIE 782
            L           E+AS  EK  N++  AT S  +  + Q         QD  + + + ++
Sbjct: 5091 L----------EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5140

Query: 783  ---GFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAV 839
               GF NK+ +  + +++  +     +  KA   +L   LE H +F L ++   +    +
Sbjct: 5141 EWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGML 5200

Query: 840  EEEGHQLLELIASHKAGLKD--MLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATD 897
             ++   +L+  A+   G +   M  + A Q + L  Q K + +  L   +    E++ T 
Sbjct: 5201 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQ 5260

Query: 898  VS------VEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMS 951
            ++       E +E  G+P  E+     +AQ +      L++   + T+  +  E+ A+  
Sbjct: 5261 INSVKCWVQETKEYLGNPTIEI-----DAQLE-----ELQILLTEATNHRQNIEKMAEEQ 5310

Query: 952  KVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMS--IR 1009
            K   +G   +L  +   Q L +  +D++  + D     + E +Q    K  S E+S  I+
Sbjct: 5311 KEKYLGLYTILPSELSLQ-LAEVALDLK--IRDQIQDKIKEVEQS---KATSQELSRQIQ 5364

Query: 1010 HLKK--TELLSKVEALKKGGVLLPND---LLEKVDSINEKWELLGKTLGEKI-QDTMAGH 1063
             L K  T +L+K++A     V    D   L E++D  N K   L   + + + Q+   G 
Sbjct: 5365 KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5424

Query: 1064 SGSSPRDLLSPESGSLVRQLEVRIKEL 1090
              +     L+      +RQ E R+ +L
Sbjct: 5425 PLAKKIGKLTELHQQTIRQAENRLSKL 5451


>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform 1
            [Homo sapiens]
          Length = 8797

 Score = 90.9 bits (224), Expect = 1e-17
 Identities = 77/310 (24%), Positives = 143/310 (46%), Gaps = 55/310 (17%)

Query: 887  DTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEE 946
            DT+ A I A D+S+ +E      +   +LC+         Q+SL            R+++
Sbjct: 7736 DTLSAYISADDISILNERVELLQRQWEELCH---------QLSL------------RRQQ 7774

Query: 947  FADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEM 1006
              +     +V       F  + +EL +WL  MES V  + D+++ EE  + L K Y  E+
Sbjct: 7775 IGERLNEWAV-------FSEKNKELCEWLTQMESKVSQNGDILI-EEMIEKLKKDYQEEI 7826

Query: 1007 SIRHLKKTELLSKVEALKKGGVLLPNDLLE-KVDSINEKWELLGKTLGEKIQDTMAGHSG 1065
            +I    K +L    E L K         +E K+  +N++W+ L   +  +++        
Sbjct: 7827 AIAQENKIQLQQMGERLAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLK----- 7881

Query: 1066 SSPRDLLSPESGSLVRQLEVRIKELKGWLRDTEL-----FIFNSCLRQEKEGTMNTEKQL 1120
                     E+   V+QL+  +  L+ WL   E       +++SC  +E +  +N +++L
Sbjct: 7882 ---------ETLVAVQQLDKNMSSLRTWLAHIESELAKPIVYDSCNSEEIQRKLNEQQEL 7932

Query: 1121 QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQ 1180
            Q      R+I++   GVAS+L LC+ LL D + C  +A+   +Q    NL+RRW  I   
Sbjct: 7933 Q------RDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQQATRNLDRRWRNICAM 7986

Query: 1181 AVQWQTRLQK 1190
            +++ + ++++
Sbjct: 7987 SMERRLKIEE 7996



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 74/302 (24%), Positives = 128/302 (42%), Gaps = 43/302 (14%)

Query: 661  ETIQNIDDWELSEMNSDSEIYPTYHVKKKH--TRLGRVSPSSSSDIASSLGESIESGPLS 718
            E IQ++++ E S ++S S+ Y + H   K+  T++ +V           +G+ +++  L 
Sbjct: 3702 EEIQSLEESE-SSLSSYSDWYGSTHKNFKNVATKIDKVD-------TVMMGKKLKT--LE 3751

Query: 719  DILSDEESSMPLAGMKKYADEKSERASSS-EKNESHSATKSA-----LIQKLMQDIQHQD 772
             +L D E    L    K A EK ERA    E+ E+    K        +++L   ++ + 
Sbjct: 3752 VLLKDMEKGHSLL---KSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKELTSTVRKEH 3808

Query: 773  -NYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDS 831
               E      + F +K     QW+ E  E       PK E+ + K  L  + S +  V S
Sbjct: 3809 MTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLS 3868

Query: 832  HCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKA 891
            H    ++V E+G  LLEL+      LKD +  + S +++L   I ++H            
Sbjct: 3869 HEPSVKSVREKGEALLELV--QDVTLKDKIDQLQSDYQDL-CSIGKEH------------ 3913

Query: 892  EILATDVSVEDEEGTGSPKAEVQLCYLE-----AQRDAVEQMSLKLYSEQYTSSSKRKEE 946
             + + +  V+D E   S   EV+   L+        D +E  SL+  ++Q        EE
Sbjct: 3914 -VFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKAMMEE 3972

Query: 947  FA 948
             A
Sbjct: 3973 IA 3974



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 94/399 (23%), Positives = 157/399 (39%), Gaps = 65/399 (16%)

Query: 790  EFIQWLNEAMETTENWTPPKA----EMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQ 845
            + I WL  A +  E WT        E++ ++ +L   L F   VD+  +LK +V   G+Q
Sbjct: 6806 DLIHWLQSAKDRLEFWTQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQ 6865

Query: 846  LLELIASHKAGLKDMLRMIASQWKELQRQI----KRQHSWILRALDTIKA--EI-----L 894
            LL L     A L+  L  I SQW +L   I    ++ H   +  L +  A  E+     L
Sbjct: 6866 LLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLPSRHAISEVMSWISL 6925

Query: 895  ATDVSVEDEEGTGSP---KA-----------EVQLCYLEAQRDAVEQMSLKLYSEQYTSS 940
              +V  +DE+   +    KA           ++ +   +   D V Q  L++ S+   S 
Sbjct: 6926 MENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESK 6985

Query: 941  SKRKEEFAD----MSKVHSVGS----------NGLLDFDSEYQE----LWDWLIDMESLV 982
               K +FA+    M+K   +             GLL+  SEY+     L  W    E  +
Sbjct: 6986 RSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRL 7045

Query: 983  MDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSI- 1041
               H +      Q  L     +E  I+  +K     +VE +++ G+ L  +  E V SI 
Sbjct: 7046 KQQHRIGDQASVQNALKDCQDLEDLIKAKEK-----EVEKIEQNGLALIQNKKEDVSSIV 7100

Query: 1042 -------NEKWELLGKTLGE-KIQDTMAGHSGSSPRDLLSPESGSLV--RQLEVRIKELK 1091
                    + W  L   +G+ KI         SS +      +  L+  R    R + L 
Sbjct: 7101 MSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLT 7160

Query: 1092 GWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREI 1130
            G L   ++ + N  L+  ++     E+ LQ F S+  ++
Sbjct: 7161 GSLEAVQVQVDN--LQNLQDDLEKQERSLQKFGSITNQL 7197



 Score = 36.6 bits (83), Expect = 0.30
 Identities = 78/367 (21%), Positives = 140/367 (38%), Gaps = 65/367 (17%)

Query: 638  KQTEVLALKLENLTKLLPQKPRG---------------ETIQNIDDWELSEMNSDSEIYP 682
            K+TE +A++ ENL K   + P G               E ++ ++D  L E     E+  
Sbjct: 1387 KRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLED-TLEEDIKTMEMVK 1445

Query: 683  T-------------YHVKKKHTRLGRVSPSSS------SDIASSLGESIESGPLSDILSD 723
            T               + +K   L  +  SSS      S I  ++ E IES  LS I+  
Sbjct: 1446 TKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQE-IES-KLSSIVGL 1503

Query: 724  EESSMPLAGMKKYADEKSERAS-------SSEKNESHSATKSALIQKLMQDIQHQDNYEA 776
            EE +   A      +    +A          E  E     +  ++  L Q  + ++N   
Sbjct: 1504 EEEAQSFAQFVTTGESARIKAKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRK 1563

Query: 777  IWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFK------LNVD 830
            I + +  F +KL   I+  + A ET +           L+       +F       +N D
Sbjct: 1564 IQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFSASARKVVNRD 1623

Query: 831  SHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIK 890
            S      A++++   +L      +  L+++L    + W+ L++++    +W+ R     K
Sbjct: 1624 SCVQEAAALQQQYEDILRRAKERQTALENLL----AHWQRLEKELSSFLTWLERG--EAK 1677

Query: 891  AEILATDVSVEDEEGTGSPKAEVQLCYLEA-QRDAVEQMSL--KLYSEQYTSSSKRKEEF 947
            A     D+S +        K E +L  ++A Q + V Q S   KL   + +  S   ++ 
Sbjct: 1678 ASSPEMDISAD------RVKVEGELQLIQALQNEVVSQASFYSKLLQLKESLFSVASKDD 1731

Query: 948  ADMSKVH 954
              M K+H
Sbjct: 1732 VKMMKLH 1738



 Score = 36.2 bits (82), Expect = 0.39
 Identities = 98/447 (21%), Positives = 186/447 (41%), Gaps = 62/447 (13%)

Query: 670  ELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDILSDEESSMP 729
            E+ E+ +D+E        KK +    +  SSS +    L E      +S + S  E  + 
Sbjct: 5112 EVIELMNDTE--------KKLSEFSLLKTSSSHEAEEKLSE--HKALVSVVNSFHEKIVA 5161

Query: 730  LAGMKKYADEKSERASSSEK--NESHSATKSALIQKLMQDIQH-----QDNYEAIWEKIE 782
            L           E+AS  EK  N++  AT S  +  + Q         QD  + + + ++
Sbjct: 5162 L----------EEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVD 5211

Query: 783  ---GFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAV 839
               GF NK+ +  + +++  +     +  KA   +L   LE H +F L ++   +    +
Sbjct: 5212 EWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGML 5271

Query: 840  EEEGHQLLELIASHKAGLKD--MLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATD 897
             ++   +L+  A+   G +   M  + A Q + L  Q K + +  L   +    E++ T 
Sbjct: 5272 RQQTLSMLQDGAAPTPGEEPPLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQ 5331

Query: 898  VS------VEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMS 951
            ++       E +E  G+P  E+     +AQ +      L++   + T+  +  E+ A+  
Sbjct: 5332 INSVKCWVQETKEYLGNPTIEI-----DAQLE-----ELQILLTEATNHRQNIEKMAEEQ 5381

Query: 952  KVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMS--IR 1009
            K   +G   +L  +   Q L +  +D++  + D     + E +Q    K  S E+S  I+
Sbjct: 5382 KEKYLGLYTILPSELSLQ-LAEVALDLK--IRDQIQDKIKEVEQS---KATSQELSRQIQ 5435

Query: 1010 HLKK--TELLSKVEALKKGGVLLPND---LLEKVDSINEKWELLGKTLGEKI-QDTMAGH 1063
             L K  T +L+K++A     V    D   L E++D  N K   L   + + + Q+   G 
Sbjct: 5436 KLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGK 5495

Query: 1064 SGSSPRDLLSPESGSLVRQLEVRIKEL 1090
              +     L+      +RQ E R+ +L
Sbjct: 5496 PLAKKIGKLTELHQQTIRQAENRLSKL 5522


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 154/741 (20%), Positives = 275/741 (37%), Gaps = 48/741 (6%)

Query: 1543 SGNIEKTFTGMQNAKQLSLLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTS 1602
            +GN +       N+      S++S  ES   G      G   + SDS   + + +S    
Sbjct: 472  NGNDDANSESDNNSSSRGDASYNSD-ESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNG 530

Query: 1603 YKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSS 1662
               N+D     S    S SS S    S  + D  +  ++  S S        SD     S
Sbjct: 531  NNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDS 590

Query: 1663 SQKMSFTGQMSLDIASSINEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRL 1722
            S   S     S D  SS + DS+ S     SSD  S  S+      +   +S++S     
Sbjct: 591  SDSDSSDSSNSSD--SSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSN-- 646

Query: 1723 TRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATD 1782
            +   +D SD + S   N S +S  +D  D SD  SSS  + + +      +  DSS +++
Sbjct: 647  SSDSSDNSDSSDSS--NSSNSSDSSDSSDSSDSSSSSDSSNSSD----SSDSSDSSNSSE 700

Query: 1783 DEIYEDCTLMSGLDYIKNELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPSDT 1842
                 D +     D                + D    N SD    S    SS+ +N SD+
Sbjct: 701  SSDSSDSSDSDSSD----------------SSDSSNSNSSDS-DSSNSSDSSDSSNSSDS 743

Query: 1843 LNIETLLNGSVKRVSENNGNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGI 1902
             +     N S    S ++ N  +SS + +     ++       + D   +   + + +  
Sbjct: 744  SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN-----SSDSNDSSNSSDSSDSS 798

Query: 1903 PERQKGKPNVTSKVSENLGSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPK 1962
                    + +S  S++  S     S+S +       DS D SN++     S        
Sbjct: 799  NSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS-----DSSDSSNSSDSSDSSDSSDGSDS 853

Query: 1963 KCPNHHHFENQSTASTPTEKSFSELALETRFNNR--QDSDALKSSDDAPSMAGKSAGCCL 2020
               N     N S +S  ++ S S  + ++  +N     SD+  SS+ + S +  S+    
Sbjct: 854  DSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSD 913

Query: 2021 ALEQNGTEENASISNISCCNCEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENE 2080
            + + + + +++  SN S  +   D  +  D+ D S  +      D ++++  S S   ++
Sbjct: 914  SSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS---NSSDSSNSSDSSNSSDSSD 970

Query: 2081 VAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLD 2140
              +  S           S            S  S SS  SD  + +N  +  +S+     
Sbjct: 971  SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030

Query: 2141 TTDSGLDDKEDIECFFEACVEGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSD 2200
            +  S   D  D     ++    DS        S+  ++S+  S+++    ++  SS+ SD
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSE-SSDSSD 1089

Query: 2201 SSLSADDADTVALSSPSSQERAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKESSGKPG 2260
            SS S+D +D    SS SS          +     SS  +++ + + S   S+  +S    
Sbjct: 1090 SSNSSDSSD----SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145

Query: 2261 ESGMPEEHNAASAKSKVQDLS 2281
            +S    + + +S  S   D S
Sbjct: 1146 DSSESSDSSDSSDSSDSSDSS 1166



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 154/764 (20%), Positives = 285/764 (37%), Gaps = 53/764 (6%)

Query: 1542 KSGNIEKTFTGMQNAKQLSLLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLT 1601
            KS + +   +   N+   S  S S S +S S            + SDS   S S  S  +
Sbjct: 546  KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDS------DSSDSDSSDSSDSDSSDSS 599

Query: 1602 SYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQS 1661
            +   + D      S D S SS S  + SK   D  +      S        S +  +  S
Sbjct: 600  NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDS 659

Query: 1662 SSQKMSFTGQMSLDIASSINEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKR 1721
            S+   S     S D + S +   +++ ++ S S + S  SE      +    S++     
Sbjct: 660  SNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSES----SDSSDSSDSDSSDS 715

Query: 1722 LTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDD-----D 1776
               S ++ SD + S   + S +S  +D  D SD  +SS  + + +     D  D     D
Sbjct: 716  SDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSD 775

Query: 1777 SSIATDDEIYEDCTLMSGLDYIKNELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEM 1836
            SS +++     D +  S      N   +      S + D    + S+    S    SS+ 
Sbjct: 776  SSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDS 835

Query: 1837 TNPSDTLNIETLLNGSVKRVSENNGNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMEN 1896
            +N SD+ +     +GS    S N  +  NSS + +      +  +    + +      ++
Sbjct: 836  SNSSDSSDSSDSSDGS-DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS 894

Query: 1897 GNIEGIPERQKGKPNVTSKVSENLGSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQD 1956
             +     +      + +S  S++  S+  + SES +    +  +S D SN++     S  
Sbjct: 895  SDSSNSSDSDSSDSSNSSDSSDS--SNSSDSSESSNSSDNS--NSSDSSNSSDSSDSSDS 950

Query: 1957 VRHLPKKCPNHHHFENQSTASTPTEKSFSELALETRFNNRQD-SDALKSSDDAPSMAGKS 2015
                     N     N S +S  ++ S S  +  +  +N  D SD+  SSD + S    +
Sbjct: 951  --------SNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSN 1002

Query: 2016 AGCCLALEQNGTEENASISNISCCNCEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKS 2075
            +      + + + +++  SN S  +   D  +  D+ D S  +   +  D + ++  S S
Sbjct: 1003 SS-----DSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1057

Query: 2076 QPENEVAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSST 2135
               ++ +  +  +   +                  S  S SS  SD  + +N  +   S+
Sbjct: 1058 SDSSDSSDSSDSSDSSDS-----------------SDSSDSSESSDSSDSSNSSDSSDSS 1100

Query: 2136 PLPLDTTDSGLDDKEDIECFFEACVEGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACS 2195
                 +  S   D  D      +    DS        S+  ++S+  SE++     ++ S
Sbjct: 1101 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS-DSSDSSDS 1159

Query: 2196 SEFSDSSLSADDADTVALSSPSSQERAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKES 2255
            S+ SDSS S+D +D+ + SS SS          +     SS  +++ + + S   S+   
Sbjct: 1160 SDSSDSSDSSDSSDS-SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1218

Query: 2256 SGKPGESGMPEEHNAASAKSKVQDLSLKANQPTDKAALHPSPKT 2299
            S    +S    + N +S  S   D S  +N      +   S  T
Sbjct: 1219 SSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDST 1262



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 145/701 (20%), Positives = 258/701 (36%), Gaps = 31/701 (4%)

Query: 1530 ASASHEMDRISYKSGNIEKTFTGMQNAKQLSLLSHSSSIESLSPGGDLFGLGIFKNGSDS 1589
            +S S +    S    +  K+ +   ++   S  S S+S +S S   D        N SDS
Sbjct: 610  SSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDS-SDNSDSSDSSNSSNSSDS 668

Query: 1590 LQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQK 1649
               S S +S  +S  SN    S   S D S SS S         D  +  ++  S S   
Sbjct: 669  SDSSDSSDSSSSSDSSNSSDSS--DSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDS 726

Query: 1650 IKRSVSDITLQSSSQKMSFTGQMSLDIASSINEDSAASLTELSSSDELSLCSEDIVLHKN 1709
               + SD +  S+S   S +   S    SS + DS+ S     SSD             N
Sbjct: 727  DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSN 786

Query: 1710 KIPESNASFRKRLTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELC 1769
                S+ S     +   ++ SD + S   + S +S  +D  + SD   SS  + + +   
Sbjct: 787  DSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSD 846

Query: 1770 IKD-EDDDSSIATDDEIYEDCTLMSGLDYIKNELQTWIRPKLSLTRDKKRCNVSDEMKGS 1828
              D  D DSS  +D     D +  S      +   +      S + +    + S +   S
Sbjct: 847  SSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS------SDSNESSNSSDSSDSSNS 900

Query: 1829 KDISSSEMTNPSDTLNIETLLNGSVKRVSENNGNGKNSSHTHELGTKRENKKTIFKVNKD 1888
             D  SS+ +N SD+ +     + S    S +N N  +SS++ +     ++  +    N  
Sbjct: 901  SDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNS- 959

Query: 1889 PYVADMENGNIEGIPERQKGKPNVTSKVSENLGSHGKEISESEHCKCKALMDSLDDSNTA 1948
               +D  N +            +  S  S +          S+        DS D S+++
Sbjct: 960  ---SDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1016

Query: 1949 GKEFVSQDVRHLPKKCPNHHHFENQSTASTPTEKSFSELALETRFNNRQDSDALKSSDDA 2008
                 S           N     + S +S  ++ S S  + ++  N+   SD+  SSD +
Sbjct: 1017 NSSDSSNS-----SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS-NSSDSSDSSDSSDSS 1070

Query: 2009 PSMAGKSAGCCLALEQNGTEENASISNISCCNCEPDVFHQKDAEDCSVHNFVKEIIDMAS 2068
             S     +      + + + +++  SN S  +   D     D+ D S  +   +  + + 
Sbjct: 1071 DSSDSSDSS-----DSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSD 1125

Query: 2069 TALKSKSQPENEVAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNY 2128
            ++  S S   ++ +  +  +   E     S            S  S SS  SD    ++ 
Sbjct: 1126 SSDSSDSSDSSDSSNSSDSSDSSES--SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1183

Query: 2129 IEEKSSTPLPLDTTDSGLDDKEDIECFFEACVEGDSDGEEPCFSSAPPNESAVPSEAAMP 2188
             +   S+     +  S   D  D     ++    DS        S+  NES+  S+++  
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSS-- 1241

Query: 2189 LQATACSSEFSDSSLSADDADTVALSSPSSQERAEVGKEVN 2229
               ++ SS  SDSS S+D +D+ + S+  S  +++ G   N
Sbjct: 1242 --DSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN 1280



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 145/709 (20%), Positives = 262/709 (36%), Gaps = 51/709 (7%)

Query: 1585 NGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQS 1644
            + SDS   S S +S   S KS  D     S  D S S+ S    +  + D  N   +  S
Sbjct: 609  DSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDS 668

Query: 1645 P--SEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSINEDSAAS----LTELSSSDELS 1698
               S+     S SD +  S S   S +   S    SS + DS +S     +  +SSD  S
Sbjct: 669  SDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728

Query: 1699 LCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSS 1758
              S D     N    S++S     + + +D SD + S   + S  S+ + D  DS   S 
Sbjct: 729  SNSSDSSDSSNSSDSSDSSD----SSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 784

Query: 1759 STLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKNELQTWIRPKLSLTRDKKR 1818
            S  +    +        DSS ++D     D +     +   +          S + D   
Sbjct: 785  SNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS-------NSSDSSDSSN 837

Query: 1819 CNVSDEMKGSKDISSSEMTNPSDTLNIETLLNGSVKRVSENNGNGKNSSHTHELGTKREN 1878
             + S +   S D S S+ +N SD+ N     + S    S N+ +  +SS ++E     ++
Sbjct: 838  SSDSSDSSDSSDGSDSDSSNRSDSSNSS---DSSDSSDSSNSSDSSDSSDSNESSNSSDS 894

Query: 1879 KKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENLGSHGKEISESEHCKCKAL 1938
              +    + D   +D  N + +          + +S  S+N  S     S          
Sbjct: 895  SDSSNSSDSDS--SDSSNSS-DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSS------ 945

Query: 1939 MDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPTEKSFSELALETR--FNNR 1996
             DS D SN++     S           N     + S +S  ++ S S  + ++    N+ 
Sbjct: 946  -DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSS 1004

Query: 1997 QDSDALKSSDDAPSM-AGKSAGCCLALEQNGTEENASISNISCCNCEPDVFHQKDAEDCS 2055
              SD+  SSD + S  +  S+    + + + + +++  S+ S  +   D  +  D+ D S
Sbjct: 1005 DSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1064

Query: 2056 VHNFVKEIIDMASTALKSKSQPENEVAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSL 2115
              +   +  D + ++  S+S   ++ +  +  +   +                  S  S 
Sbjct: 1065 DSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDS--------------SDSSDSSD 1110

Query: 2116 SSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACVEGDSDGEEPCFSSAP 2175
            SS  SD  + +N  +   S+     +  S   D  D     ++    DS        S+ 
Sbjct: 1111 SSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSD 1170

Query: 2176 PNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQERAEVGKEVNGLPQTS 2235
             ++S+  S ++     ++ SS+ SDSS S+D +D+   S  S    +    + +    +S
Sbjct: 1171 SSDSSDSSNSS----DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1226

Query: 2236 SGCAENLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDLSLKA 2284
                 N     S      +SS     S   +  ++ S  +   D   K+
Sbjct: 1227 DSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 120/553 (21%), Positives = 190/553 (34%), Gaps = 41/553 (7%)

Query: 1325 SKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLN 1384
            S DSS SS  S  D    SN            S NS   S      D++++ +S+    N
Sbjct: 773  SSDSSDSSNSS--DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS--N 828

Query: 1385 AVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKVGDLN 1444
            + D S S+  ++  D    D+ +      ++  +S    +SS SS S     +    D N
Sbjct: 829  SSDSSDSSNSSDSSDSS--DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSN 886

Query: 1445 --SITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLRGF 1502
              S +  + D          D     D S    S            SE ++  D      
Sbjct: 887  ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS---------DSSESSNSSD------ 931

Query: 1503 YFDKKSCKSKHQTTELQPDVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLSLL 1562
              +  S  S + +              +S S      S  S +   + +   N+   S  
Sbjct: 932  --NSNSSDSSNSSDSSD----------SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS 979

Query: 1563 SHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSS 1622
            S+SS     S   D        N SDS   S S +S  +S  SN    S  +S D S SS
Sbjct: 980  SNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS--NSSDSSDSS 1037

Query: 1623 GSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSINE 1682
             S            +   N    S+       SD +  S S   S +   S    SS + 
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097

Query: 1683 DSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNVSC 1742
            DS+ S     SSD           + +   +S+ S     + + +D SD + S   + S 
Sbjct: 1098 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157

Query: 1743 TSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKNEL 1802
             S+ + D  DS   S S+ +    +     +  DSS ++D     D +  S      +  
Sbjct: 1158 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1217

Query: 1803 QTWIRPKLSLTRDKKRCNVSDEMKGSKDIS----SSEMTNPSDTLNIETLLNGSVKRVSE 1858
             +      S + D    + S +   S D S    SS+ ++ SD+ +     + S  +   
Sbjct: 1218 DSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGN 1277

Query: 1859 NNGNGKNSSHTHE 1871
             N NG +S    E
Sbjct: 1278 GNNNGSDSDSDSE 1290



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 111/599 (18%), Positives = 206/599 (34%), Gaps = 48/599 (8%)

Query: 171  DANGNYTR------QTDILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITA 224
            D+NGN         ++D  +  S+ +     DS    D S       S +  S D   + 
Sbjct: 525  DSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSD 584

Query: 225  FELSDYSPSEDL-LSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSIS 283
             + SD S S+    S   D + S   +   DS   S+ + +  +           +DS  
Sbjct: 585  SDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD 644

Query: 284  TNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSET 343
            +N S++     S  S S D        ++S   +    +    SS+    ++++  S+ +
Sbjct: 645  SNSSDS-----SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699

Query: 344  VQQESSSSSHHDAKNQQPVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKN 403
               +SS SS  D+ +       N++      D  N ++ S +              +  +
Sbjct: 700  ESSDSSDSSDSDSSDSSDSSNSNSSDS----DSSNSSDSSDSS-----------NSSDSS 744

Query: 404  DLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVG 463
            D   +       D     + S  S  D  D S       SS  N  S +S S +  +   
Sbjct: 745  DSSDSSNSSDSSDSSDSSNSSDSS--DSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSD 802

Query: 464  NGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKN 523
            + N  ++        S S    +      S        S +            S +   +
Sbjct: 803  SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSS 862

Query: 524  TKSSAVPNGELSYTSKAIEGPQTNSASTSSLEPCNQRSWNAKLQ---LQSETSSSPAFTQ 580
              S +  + + S +S + +   +N +S SS    +  S ++        S++S S   + 
Sbjct: 863  NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSD 922

Query: 581  SSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQT 640
            SSESS  SDN  S     S   S    +S+ S  + + +   +   SD   +  S    +
Sbjct: 923  SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNS 982

Query: 641  EVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSS 700
                                    +  D   S  +SDS            +     S SS
Sbjct: 983  S--------------DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028

Query: 701  SSDIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSA 759
            +S  +S   +S +S   SD  S + S    +     + + S+ + SS+ ++S  +++S+
Sbjct: 1029 NSSDSSDSSDSSDSSDSSD--SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS 1085



 Score = 38.5 bits (88), Expect = 0.078
 Identities = 96/537 (17%), Positives = 186/537 (34%), Gaps = 26/537 (4%)

Query: 228  SDYSPSEDLL--SGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTN 285
            SD S S D    S   D + S   +   DS   S+          S    +  + + S +
Sbjct: 726  SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785

Query: 286  GSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQ 345
               + + + S  S S D     +  ++S   +        SS+S ++ ++++  S  +  
Sbjct: 786  NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDS-SDSSNSSDSSDS 844

Query: 346  QESSSSSHHDAKNQQPVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDL 405
             +SS  S  D+ N+      N++      D  N ++ S +  +          ++  +  
Sbjct: 845  SDSSDGSDSDSSNRSD--SSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSD 902

Query: 406  KGNGGKRQMVDLKPEMSRSTPS-LVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGN 464
              +       D     + S  S   +  D S       SS  +  S +S S +  +   +
Sbjct: 903  SDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDS 962

Query: 465  GNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNT 524
             N  ++   +  + S S    +      S        S            + S   + ++
Sbjct: 963  SNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSS 1022

Query: 525  KSSAVPNGELSYTSKAIEGPQTNSASTSSLEPCNQR--SWNAKLQLQSETSSSPAFTQSS 582
             SS   N   S  S        +S S+ S +  N    S ++     S++S S   + SS
Sbjct: 1023 NSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1082

Query: 583  ESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEV 642
            ESS  SD         S + S    +S  S  + + +  ++   SD   +  S       
Sbjct: 1083 ESSDSSD---------SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133

Query: 643  LALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSS 702
             +    N +         ++  + D  + S+ +  S+           +     S SS S
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSD-------SSDSSDSSNSSDSSDS 1186

Query: 703  DIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSA 759
              +S   +S +S   SD  S + S    +     + + S+ + SS+ NES  ++ S+
Sbjct: 1187 SDSSDSSDSSDSSDSSD--SSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSS 1241


>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
            [Homo sapiens]
          Length = 6907

 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 90/409 (22%), Positives = 177/409 (43%), Gaps = 80/409 (19%)

Query: 790  EFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLEL 849
            +  + + +   T E W   + ++ +LK  L+      L   S   L E + E+ H   EL
Sbjct: 5797 QLAEMIKQFQSTVETWDQCEKKIKELKSRLQV-----LKAQSEDPLPE-LHEDLHNEKEL 5850

Query: 850  IASHKAGLKDMLRMIASQWKELQRQIKRQHSWI--LRALDTIKAEILATDVSVEDEEGTG 907
            I                  KEL++ +    SW   L+ L T+KA+ L   V VED     
Sbjct: 5851 I------------------KELEQSLA---SWTQNLKELQTMKAD-LTRHVLVED----- 5883

Query: 908  SPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSE 967
                      +   ++ +E +  + + +     + RK+E  D      V       F+ +
Sbjct: 5884 ----------VMVLKEQIEHLH-RQWEDLCLRVAIRKQEIEDRLNTWVV-------FNEK 5925

Query: 968  YQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEAL-KKG 1026
             +EL  WL+ ME+ V+ + D+ + EE  + L K    E+++    K +L    + L K  
Sbjct: 5926 NKELCAWLVQMENKVLQTADISI-EEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKAS 5984

Query: 1027 GVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVR 1086
                  ++ +K++ IN++W+ L   +G +++                 E+ + ++QL+  
Sbjct: 5985 NKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLK--------------ETFAFIQQLDKN 6030

Query: 1087 IKELKGWLR--DTEL---FIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASIL 1141
            +  L+ WL   ++EL    +++ C  QE +  +  ++ LQ      R+I+Q   GV S+ 
Sbjct: 6031 MSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQ------RDIEQHSAGVESVF 6084

Query: 1142 RLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQK 1190
             +C  LL D + C    +   +Q    +L+RRW  I   +++ + ++++
Sbjct: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEE 6133



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 73/332 (21%), Positives = 137/332 (41%), Gaps = 53/332 (15%)

Query: 764  LMQDIQHQ-DNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA----EMDDLKLY 818
            L + I H+    +A+ + +  +    D+  +WL  +  T   W         ++D ++  
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSN 4987

Query: 819  LETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQI--- 875
            +     F   VD   +LK AV   G+QLL L  +  A L+  L     +W  L  Q+   
Sbjct: 4988 INNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDI 5047

Query: 876  -KRQHSWILRALDTIKA--EILATDVSVE----DEEGTGSPKAEVQLCYLEAQR------ 922
             ++ H   +  L + KA  E+++   +VE    DE+   SP +  Q+ +L  +       
Sbjct: 5048 QEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME 5107

Query: 923  --------DAVEQMSLKLYSEQYTSSSKRKEEFAD-----MSKVHSVGSNGLLDFDSEY- 968
                    D V Q  L+L +    S    + EFA+       + H V  +G+L+   ++ 
Sbjct: 5108 MDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRV--HGMLNRKIQHL 5165

Query: 969  QELWDWLIDMESLVMDSHD-LMMSEEQQQHLYKRYSV---------------EMSIRHLK 1012
            ++L + + + E+ +   ++ L   EE+ + L K  SV               +++I+   
Sbjct: 5166 EQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKA 5225

Query: 1013 KTELLSKVEALKKGGVLLPNDLLEKVDSINEK 1044
              EL      L+ G V L  D   ++D + +K
Sbjct: 5226 LDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257


>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
            [Homo sapiens]
          Length = 6885

 Score = 79.0 bits (193), Expect = 5e-14
 Identities = 90/409 (22%), Positives = 177/409 (43%), Gaps = 80/409 (19%)

Query: 790  EFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLEL 849
            +  + + +   T E W   + ++ +LK  L+      L   S   L E + E+ H   EL
Sbjct: 5797 QLAEMIKQFQSTVETWDQCEKKIKELKSRLQV-----LKAQSEDPLPE-LHEDLHNEKEL 5850

Query: 850  IASHKAGLKDMLRMIASQWKELQRQIKRQHSWI--LRALDTIKAEILATDVSVEDEEGTG 907
            I                  KEL++ +    SW   L+ L T+KA+ L   V VED     
Sbjct: 5851 I------------------KELEQSLA---SWTQNLKELQTMKAD-LTRHVLVED----- 5883

Query: 908  SPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSE 967
                      +   ++ +E +  + + +     + RK+E  D      V       F+ +
Sbjct: 5884 ----------VMVLKEQIEHLH-RQWEDLCLRVAIRKQEIEDRLNTWVV-------FNEK 5925

Query: 968  YQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEAL-KKG 1026
             +EL  WL+ ME+ V+ + D+ + EE  + L K    E+++    K +L    + L K  
Sbjct: 5926 NKELCAWLVQMENKVLQTADISI-EEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKAS 5984

Query: 1027 GVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVR 1086
                  ++ +K++ IN++W+ L   +G +++                 E+ + ++QL+  
Sbjct: 5985 NKSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLK--------------ETFAFIQQLDKN 6030

Query: 1087 IKELKGWLR--DTEL---FIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASIL 1141
            +  L+ WL   ++EL    +++ C  QE +  +  ++ LQ      R+I+Q   GV S+ 
Sbjct: 6031 MSNLRTWLARIESELSKPVVYDVCDDQEIQKRLAEQQDLQ------RDIEQHSAGVESVF 6084

Query: 1142 RLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQK 1190
             +C  LL D + C    +   +Q    +L+RRW  I   +++ + ++++
Sbjct: 6085 NICDVLLHDSDACANETECDSIQQTTRSLDRRWRNICAMSMERRMKIEE 6133



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 73/332 (21%), Positives = 137/332 (41%), Gaps = 53/332 (15%)

Query: 764  LMQDIQHQ-DNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA----EMDDLKLY 818
            L + I H+    +A+ + +  +    D+  +WL  +  T   W         ++D ++  
Sbjct: 4928 LNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQDLDTIRSN 4987

Query: 819  LETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQI--- 875
            +     F   VD   +LK AV   G+QLL L  +  A L+  L     +W  L  Q+   
Sbjct: 4988 INNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTMLITQLPDI 5047

Query: 876  -KRQHSWILRALDTIKA--EILATDVSVE----DEEGTGSPKAEVQLCYLEAQR------ 922
             ++ H   +  L + KA  E+++   +VE    DE+   SP +  Q+ +L  +       
Sbjct: 5048 QEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQKHKEFRME 5107

Query: 923  --------DAVEQMSLKLYSEQYTSSSKRKEEFAD-----MSKVHSVGSNGLLDFDSEY- 968
                    D V Q  L+L +    S    + EFA+       + H V  +G+L+   ++ 
Sbjct: 5108 MDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRV--HGMLNRKIQHL 5165

Query: 969  QELWDWLIDMESLVMDSHD-LMMSEEQQQHLYKRYSV---------------EMSIRHLK 1012
            ++L + + + E+ +   ++ L   EE+ + L K  SV               +++I+   
Sbjct: 5166 EQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLAIKSKA 5225

Query: 1013 KTELLSKVEALKKGGVLLPNDLLEKVDSINEK 1044
              EL      L+ G V L  D   ++D + +K
Sbjct: 5226 LDELKQSYLTLESGAVPLLEDTASRIDELFQK 5257


>gi|154800457 centrosomal protein 68kDa [Homo sapiens]
          Length = 757

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 79/323 (24%), Positives = 136/323 (42%), Gaps = 44/323 (13%)

Query: 594 PVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKL 653
           P P   + K     A  P+      +  E     DEYLALP+ L Q   L   L +++ L
Sbjct: 446 PSPRPEREKRTSQSARRPTCTESRWKSEEEVESDDEYLALPARLTQVSSLVSYLGSISTL 505

Query: 654 LPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIE 713
           +   P G+ I+     E+S+ +  +                   PSSSS      G +++
Sbjct: 506 VTL-PTGD-IKGQSPLEVSDSDGPASF-----------------PSSSSQSQLPPGAALQ 546

Query: 714 SGPLSDILSDEESSMP--LAGMKKYADEKSERASSSEKNESHSA----TKSALIQKLMQ- 766
                    D E   P  L    +  D   E +  S +    S+    T+ +L  +L + 
Sbjct: 547 GS------GDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRW 600

Query: 767 -----DIQHQ-------DNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDD 814
                D++ Q          E++ + ++ F  +L+E I WL    + T++ T  ++ +  
Sbjct: 601 PFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTS 660

Query: 815 LKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQ 874
           LK  L+ +  FK ++D H +L E+V ++G  LL+ +  +   L+D+L  IA Q  EL+  
Sbjct: 661 LKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESH 720

Query: 875 IKRQHSWILRALDTIKAEILATD 897
             R +  IL +LD +    L  D
Sbjct: 721 ADRLYDSILASLDMLAGCTLIPD 743


>gi|154277120 spectrin repeat containing, nuclear envelope 1 isoform 3
            [Homo sapiens]
          Length = 982

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 39/159 (24%), Positives = 80/159 (50%), Gaps = 25/159 (15%)

Query: 1037 KVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRD 1096
            K+  +N++W+ L   +  +++                 E+   V+QL+  +  L+ WL  
Sbjct: 20   KLGKVNDRWQHLLDLIAARVKKLK--------------ETLVAVQQLDKNMSSLRTWLAH 65

Query: 1097 TEL-----FIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDR 1151
             E       +++SC  +E +  +N +++LQ      R+I++   GVAS+L LC+ LL D 
Sbjct: 66   IESELAKPIVYDSCNSEEIQRKLNEQQELQ------RDIEKHSTGVASVLNLCEVLLHDC 119

Query: 1152 ETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQK 1190
            + C  +A+   +Q    NL+RRW  I   +++ + ++++
Sbjct: 120  DACATDAECDSIQQATRNLDRRWRNICAMSMERRLKIEE 158


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 58.5 bits (140), Expect = 7e-08
 Identities = 237/1293 (18%), Positives = 491/1293 (37%), Gaps = 187/1293 (14%)

Query: 71   PEIETWLRMTSERVRDLTYSVQQDSDSK----HVDVHLVQLKDICEDI--------SDHV 118
            P+++   ++ S++  D++Y   Q S+ +     +   +++ +D+ + +         +H 
Sbjct: 1392 PKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD 1451

Query: 119  EQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQG------LQDA 172
            E+I  L      +K     +    +  A Q +  +L+ +++  +E + +       L  A
Sbjct: 1452 ERIKQLQVELCEMKQKPEEIGE--ESRAKQQIQRKLQAALISRKEALKENKSLQEELSLA 1509

Query: 173  NGNYTRQT----DILQAFSEETKE-----GRLDSLTEVDDSGQLTIKCSQNYL---SLDC 220
             G   R T    D+    S + KE     GRL  L E  D  +L  +  ++ L   SL  
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERD--KLITEMDRSLLENQSLSS 1567

Query: 221  GITAFELSDYSPSED---LLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTV 277
               + +L+    +ED   L+  +  + SS++         + E++KE+  L++S   ++ 
Sbjct: 1568 SCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSN 1627

Query: 278  AADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAA 337
             A+ I     + V E V Q    +  K    E N    E+Q    L  +    E +    
Sbjct: 1628 EAERI-----QHVVEAVRQEKQELYGKLRSTEANKKETEKQ----LQEAEQEMEEMKEKM 1678

Query: 338  QPSSETVQQESSSSSHHDAKNQQPVPCENATPKRTIRDCFNYNEDSPTQ--------PTL 389
            +  +++ QQ+       + + +  V     T K  +    + N     +         TL
Sbjct: 1679 RKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETL 1738

Query: 390  PKRGLFLKEET---------FKNDLKGNGGKR----------QMVDLKPEMSRSTPSLVD 430
             K+   L  E           K+ ++GN  K+             ++  E ++S P   +
Sbjct: 1739 SKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETE 1798

Query: 431  PPDRSKLCL--VLQSSYPNSPSA---ASQSYECLHKVGNGNLENTVKFHIKEISSSLGRL 485
              D   +        S P++ SA    S+ +    ++ N         ++++I     R+
Sbjct: 1799 EQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN---------YLQQIDQLKERI 1849

Query: 486  NDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGK----QAKNTKSSAVPNGELSYTSKAI 541
                +EK + K+  +T E        +  T  G+    Q + TK + +        S+  
Sbjct: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909

Query: 542  EGPQTNSASTSSLEPCNQRSWNAKLQLQSETSS-----SPAFTQSSESSVGSDNIMSPVP 596
            +  +T       LE   +R  N   +L     +     + A  ++        N+   V 
Sbjct: 1910 KLKETAEEEKDDLE---ERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVS 1966

Query: 597  LLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQ 656
             L + K +  +  +        E +E   G+ +     SH K+ + L  + +   K L +
Sbjct: 1967 ELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQK 2026

Query: 657  K--PRGETIQNID------DWELSEMNSDSEI------YPTYHVKKKHTRLGRVS---PS 699
                  E I  ++      ++  +E   D EI          H KK    L         
Sbjct: 2027 DCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDD 2086

Query: 700  SSSDIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSA 759
            + S+ A  L ++++     ++ S++ES   +    K  DE  ER    +  E H   K  
Sbjct: 2087 TQSEAARVLADNLKLK--KELQSNKES---VKSQMKQKDEDLERRLE-QAEEKHLKEKKN 2140

Query: 760  LIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTEN----WTPPKAEM-DD 814
            + +KL    + + + E    +I+  +NK D+ +Q L E +++T      +T   + + DD
Sbjct: 2141 MQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200

Query: 815  LKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQ 874
                ++    ++         KE       + + L   + + LKD LR ++   +EL+  
Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKE-------EEIRLKEDNCSVLKDQLRQMSIHMEELKIN 2253

Query: 875  IKR----QHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVE-QMS 929
            I R    +  W  +A   ++ +    D    + +   S   E +  Y  +Q +  + +  
Sbjct: 2254 ISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE 2313

Query: 930  LKLYSEQYT----SSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDS 985
            LK   +Q T    S  K KE+  ++  +       + +    Y++L   L     L    
Sbjct: 2314 LKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRL 2373

Query: 986  HDLMMSEEQQQHLY---KRYSVEMSIRHLKK------TELLSKVEALKKGGVLLPNDLLE 1036
            H+ +  +EQ+       K  +++++I  L++       EL + +   ++  ++L  +  +
Sbjct: 2374 HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK 2433

Query: 1037 KVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRD 1096
             VD  N+  E L     E IQ                        QL+  +K +     D
Sbjct: 2434 AVDKTNQLMETLKTIKKENIQQK---------------------AQLDSFVKSMSSLQND 2472

Query: 1097 TELFIFNSCLRQEKEGTMNTEKQ--LQYFKSLCREIKQRRRGVASILRLCQHLLD-DRET 1153
             +  + +    +E+  ++  EK   +Q   +   ++K+  RG+ S      H+ D + E 
Sbjct: 2473 RDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS------HMDDLNSEN 2526

Query: 1154 CNLNAD----HQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDL 1209
              L+A+     + +  +I   + + + ++   +Q    L+ K  K  E L   +    DL
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDL 2586

Query: 1210 NGMSEDALEWDEMDISNKLISLNEESNDLDQEL 1242
               S +AL+ ++ D+S ++ SL    + L +++
Sbjct: 2587 R-RSFNALQEEKQDLSKEIESLKVSISQLTRQV 2618



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 115/595 (19%), Positives = 243/595 (40%), Gaps = 80/595 (13%)

Query: 713  ESGPLSDILSDEESSMPLAGMKKYADEKSERASSS-EKNESHSATKSALIQKLMQDIQHQ 771
            ++G    ++ +EESS+P    ++ + E   R S     N++    KS             
Sbjct: 617  DTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVP 676

Query: 772  DNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKA-EMDDLKLYLETHLSFKLNVD 830
            D  +   +++E   +++ E     ++A E  E     KA E+ +L   +E    FK N D
Sbjct: 677  DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIE---EFKKNAD 733

Query: 831  SHCALKEAVEEEGHQLLELI--ASHKAGLKDMLRMIASQWKELQRQIKRQH-------SW 881
            ++ +   A+ EE  QLL  +   S    L+  ++ +     E +RQ +  +       + 
Sbjct: 734  NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNL 793

Query: 882  ILRALDTIKAEILATDVSVE-------------DEEGTGSPKAEVQLCYLEAQ----RDA 924
            +   + ++  E  + DV +E              E+ T     + QL   E++     + 
Sbjct: 794  LTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAER 853

Query: 925  VEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMD 984
            V  +S K+  E   + S+++ E   M ++       LL+   + + L   + + +  V +
Sbjct: 854  VRHISSKV-EELSQALSQKELEITKMDQL-------LLEKKRDVETLQQTIEEKDQQVTE 905

Query: 985  SHDLMMSEEQQQHLYKRYSVEMSIRHLK-KTELLSKVEALKKGGVLLPNDLLEKVDSINE 1043
                 M+E+  Q   +++S+ + I+ LK +  LLS+ E  KK  V   N++   +    +
Sbjct: 906  I-SFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYD 964

Query: 1044 KWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEV-------------RIKEL 1090
            +    G+   E++Q            DLL  E+    R+L+              R++E 
Sbjct: 965  EMSPAGQISKEELQHEF---------DLLKKENEQRKRKLQAALINRKELLQRVSRLEEE 1015

Query: 1091 KGWLRD---TELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRL-CQH 1146
               L+D    E+ +  +   + +E   N E   +   S C+EI+   +   S   +  QH
Sbjct: 1016 LANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQH 1075

Query: 1147 LLDDRETCNLNADHQPMQLI------IVNLERRWEAIVMQAVQWQTRLQKKM-----GKE 1195
            +  D E   L A+ Q   L+      + +   + + +  +  + Q  +QK +       +
Sbjct: 1076 IRKDLEE-KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASD 1134

Query: 1196 SETLNVIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLK 1250
             +++ ++   ++     +  +  W + ++  K+++L +E   L ++LQ  + S K
Sbjct: 1135 GDSVALVKETVVISPPCTGSSEHW-KPELEEKILALEKEKEQLQKKLQEALTSRK 1188



 Score = 36.6 bits (83), Expect = 0.30
 Identities = 120/595 (20%), Positives = 226/595 (37%), Gaps = 132/595 (22%)

Query: 712  IESGPLSDILSDEESSMPLAGMKKYADEKSE----RASSSEKNESHSATKSALIQKLMQD 767
            +ES    D  S  E +  L G    A  K++     A   E     S+T S L +K  + 
Sbjct: 1280 LESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEV 1339

Query: 768  IQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKL 827
             Q Q+       +IE         ++ ++   E        K E   L++    HL    
Sbjct: 1340 FQLQEQINKQGLEIES--------LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR--- 1388

Query: 828  NVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALD 887
                   L+  ++E     L+ + S K   ++ +  ++ Q  E +  + +  + I+   D
Sbjct: 1389 ------ELQPKLDE-----LQKLISKK---EEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434

Query: 888  TIKAEILATDVSVEDEEGTGSPKA-EVQLCYLEAQRDAV-------EQMSLKLYS----- 934
             IKA  L T + ++ +E     K  +V+LC ++ + + +       +Q+  KL +     
Sbjct: 1435 LIKA--LHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISR 1492

Query: 935  -EQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQ---ELWDWLIDMESLVMDSHDLMM 990
             E    +   +EE +         +  L D +S+     +  D ++   +L+ +  D ++
Sbjct: 1493 KEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLI 1552

Query: 991  SEEQQQHLYKRYSVEMSIRHLK---------KTELLSKVEALKKGGVLLPNDLLEKVDSI 1041
            +E   + L +  S+  S   LK         K +L+ ++E+LK   +    +  EK   +
Sbjct: 1553 TE-MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKEL 1611

Query: 1042 NEKWELLGKTL------GEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLR 1095
             +++E+L ++        E+IQ  +                   VRQ +   +EL G LR
Sbjct: 1612 QKEYEILLQSYENVSNEAERIQHVVEA-----------------VRQEK---QELYGKLR 1651

Query: 1096 DTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCN 1155
             TE          +KE    TEKQLQ  +    E+K++ R  A                 
Sbjct: 1652 STEA--------NKKE----TEKQLQEAEQEMEEMKEKMRKFA----------------- 1682

Query: 1156 LNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSED 1215
                 +  Q  I+ LE               RL+ ++    +T       L+  N   ++
Sbjct: 1683 -----KSKQQKILELEEE-----------NDRLRAEVHPAGDTAKECMETLLSSNASMKE 1726

Query: 1216 ALEWDEMD---ISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPGYDEEADN 1267
             LE  +M+   +S K  SL  E + L +E+Q +   ++   +   +    E+ DN
Sbjct: 1727 ELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDN 1781


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 58.2 bits (139), Expect = 9e-08
 Identities = 122/523 (23%), Positives = 218/523 (41%), Gaps = 66/523 (12%)

Query: 711  SIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQH 770
            S+E G L D+  +EE  M  +      +E+ E     E   SHS      I ++ Q++  
Sbjct: 393  SMERG-LRDL--EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSR 449

Query: 771  QDN-YEAIWEKIEGFVNKLDE---FIQWLNEAMETTENWTPP-KAEMDDLKLYLETHLSF 825
            +D    A+  K+E   N+  +    I+ L E++   E      + E+D L+L LE   + 
Sbjct: 450  KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM 509

Query: 826  KLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDML-------RMIASQWKELQRQIK-- 876
             LN  +   +++  EE+G Q  E+       LKDML        ++  + + LQ Q++  
Sbjct: 510  -LNKKTK-QIQDMAEEKGTQAGEI-----HDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562

Query: 877  -RQHSWILRALDTIKAEILATDVSVED-EEGTGSPKAEVQLCYLEAQRDAVEQMS----- 929
             +Q S +   + +++A+   TD ++   EE     +  ++    +  RD  E+       
Sbjct: 563  EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNY 622

Query: 930  ---LKLYSEQYT----SSSKRKEEFADMSK-VHSVGSNGLLDFDSEYQELWDWL------ 975
               LK   E+ +      S+++    D+ +   S+ S+GL   DS  + L   L      
Sbjct: 623  KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK-DSRLKTLEIALEQKKEE 681

Query: 976  -IDMESLVMDSHDLMMS-------EEQQQHL------YKRYSVEMSIRHLKKTELLSKVE 1021
             + MES +  +H+  +         ++ QHL      YK  S +      +  E+L +VE
Sbjct: 682  CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 741

Query: 1022 ALKKGGVLLPNDLLEKVDSINEKW-ELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSL- 1079
              K        +L  +V   N+K   L  K   EK +            D L+  S  L 
Sbjct: 742  NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQ 801

Query: 1080 --VRQLEVRIKELKGWLRDTELFIFNS--CLRQEKEGTMNTEKQLQYFKSLCREIKQRRR 1135
              +R+ + RI+EL+  LR++          L QE+    N EKQ++       ++KQ   
Sbjct: 802  DSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 861

Query: 1136 GVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIV 1178
             + + L   Q  L ++ET   N   +  + +   LE + EA++
Sbjct: 862  SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALL 904


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
          Length = 1116

 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 116/505 (22%), Positives = 210/505 (41%), Gaps = 67/505 (13%)

Query: 733  MKKYADEKSERASSSEKNESHSATKSALIQ----KLMQDIQHQDN-YEAIWEKIEGFVNK 787
            MK   ++  E  SS E        K+A +Q    ++ Q++  +D    A+  K+E   N+
Sbjct: 436  MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQ 495

Query: 788  LDE---FIQWLNEAMETTENWTPP-KAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEG 843
              +    I+ L E++   E      + E+D L+L LE   +  LN  +   +++  EE+G
Sbjct: 496  FSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM-LNKKTK-QIQDMAEEKG 553

Query: 844  HQLLELIASHKAGLKDML-------RMIASQWKELQRQIK---RQHSWILRALDTIKAEI 893
             Q  E+       LKDML        ++  + + LQ Q++   +Q S +   + +++A+ 
Sbjct: 554  TQAGEI-----HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADT 608

Query: 894  LATDVSVED-EEGTGSPKAEVQLCYLEAQRDAVEQMS--------LKLYSEQYT----SS 940
              TD ++   EE     +  ++    +  RD  E+          LK   E+ +      
Sbjct: 609  TNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDL 668

Query: 941  SKRKEEFADMSK-VHSVGSNGLLDFDSEYQELWDWL-------IDMESLVMDSHDLMMS- 991
            S+++    D+ +   S+ S+GL   DS  + L   L       + MES +  +H+  +  
Sbjct: 669  SEKEASLLDLKEHASSLASSGLKK-DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEA 727

Query: 992  ------EEQQQHL------YKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVD 1039
                   ++ QHL      YK  S +      +  E+L +VE  K        +L  +V 
Sbjct: 728  RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVK 787

Query: 1040 SINEKW-ELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSL---VRQLEVRIKELKGWLR 1095
              N+K   L  K   EK +            D L+  S  L   +R+ + RI+EL+  LR
Sbjct: 788  DQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR 847

Query: 1096 DTELFIFNS--CLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRET 1153
            ++          L QE+    N EKQ++       ++KQ    + + L   Q  L ++ET
Sbjct: 848  ESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 907

Query: 1154 CNLNADHQPMQLIIVNLERRWEAIV 1178
               N   +  + +   LE + EA++
Sbjct: 908  HLTNLRAERRKHLEEVLEMKQEALL 932


>gi|33188443 microfilament and actin filament cross-linker protein
            isoform b [Homo sapiens]
          Length = 5938

 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 81/388 (20%), Positives = 160/388 (41%), Gaps = 56/388 (14%)

Query: 784  FVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEG 843
            F + L+  + WL +  E   N  PP AE   +K  ++     +  +D   A  + ++ EG
Sbjct: 3784 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3843

Query: 844  HQLLELI-ASHKAGLKDMLRMIASQWKEL-----QRQIKRQHSWILRALDTIKAEILATD 897
             ++ +    + +  +   L  + S+W EL      RQ + +   +L       AE ++  
Sbjct: 3844 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3903

Query: 898  VSVEDEE-------GTGSPKAEVQLCYLEAQRDAVEQMSLKLY----------------- 933
            +SV +++       GT + K + Q+   +A  + +E  +  ++                 
Sbjct: 3904 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3963

Query: 934  ----SEQYTSSSKRKEEFAD-----MSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMD 984
                SE+  S   R  E  D      + +    SN  L F  +  E+ +WL ++E  +  
Sbjct: 3964 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-FGEDEVEVLNWLAEVEDKL-- 4020

Query: 985  SHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEK 1044
               + + + +Q  L+++++  +++         +  +A+K G  LL     E+V  I EK
Sbjct: 4021 -SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 4079

Query: 1045 WELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNS 1104
             + + KT    I  T    S  + R L   ++  L  + +   +EL GWLR+ E  +  S
Sbjct: 4080 LDGI-KTRYADITVT----SSKALRTL--EQARQLATKFQSTYEELTGWLREVEEELATS 4132

Query: 1105 CLRQEKEGTMNTEKQLQYFKSLCREIKQ 1132
                   G   T +Q+  F+   +E+K+
Sbjct: 4133 ------GGQSPTGEQIPQFQQRQKELKK 4154



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 102/485 (21%), Positives = 187/485 (38%), Gaps = 79/485 (16%)

Query: 760  LIQKLMQDIQH-QDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLY 818
            L + L + I H Q   E     +  F + L+E + WL    E  +   P   +   +++ 
Sbjct: 4747 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4806

Query: 819  LETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKA-GLKDMLRMIASQWKELQRQIKR 877
            L  H   K +V +H A  E V + G++LLE  A   A  L+  L  +   W+ + ++ + 
Sbjct: 4807 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4866

Query: 878  QHSWI---LRALDTIKAEI---------LATDVSVEDEEGTGSPKAEVQL-------CYL 918
            +   +   L+      +EI         + + +S     G     A  QL         L
Sbjct: 4867 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4926

Query: 919  EAQRDAVEQM----SLKLYSEQYTSSSKRKEEFADM--SKVHSVGS-------------N 959
            +A+ +   Q+     L L S   + S  + E+   +   K H V S             N
Sbjct: 4927 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALN 4986

Query: 960  GLLDFDSEYQELWDWLIDME---------SLVMDSHDLMMSEEQQQHLYKRYSVEMSIRH 1010
               +F +  QE  +WL   E         SL++++  L   EE +    +  +    I  
Sbjct: 4987 LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNT-VLSQIEEHKVFANEVNAHRDQIIE 5045

Query: 1011 LKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRD 1070
            L +T    K  + K+  VL+ N L+    S+  +WE   K +   I+           R 
Sbjct: 5046 LDQTGNQLKFLSQKQDVVLIKNLLV----SVQSRWE---KVVQRSIE-----------RG 5087

Query: 1071 LLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEK---QLQYFKSLC 1127
                ++    +Q     K+L  WL D E     S L  E E + + +K   QL   K   
Sbjct: 5088 RSLDDARKRAKQFHEAWKKLIDWLEDAE-----SHLDSELEISNDPDKIKLQLSKHKEFQ 5142

Query: 1128 REIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTR 1187
            + +  ++    + +R  + L   +E   L  D Q +   +  +  +W+ +  ++V+ Q +
Sbjct: 5143 KTLGGKQPVYDTTIRTGRAL---KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 5199

Query: 1188 LQKKM 1192
            L++ +
Sbjct: 5200 LEEAL 5204



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 103/532 (19%), Positives = 203/532 (38%), Gaps = 92/532 (17%)

Query: 775  EAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCA 834
            +A     + F    DE   WL++         P  A+++ L+  L+ +  F+ +++ H  
Sbjct: 3229 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSG 3288

Query: 835  LKEAVEEEGHQLLELI--ASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAE 892
              E +  EG  LL  +     K  L++ L  + + W+EL ++   + S +   +   KA+
Sbjct: 3289 SYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ--KAQ 3346

Query: 893  ILATDVS-----VEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEF 947
                 V      +ED         + ++  L    D V+  S  L S+   +  +++   
Sbjct: 3347 KYQWHVEDLVPWIED--------CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 3398

Query: 948  ADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMS 1007
             ++       +  +L   SE  E  D + D ++ +  + D +  E Q     K  S+E  
Sbjct: 3399 LEILN----SAADILINSSEADE--DGIRDEKAGINQNMDAVTEELQA----KTGSLEEM 3448

Query: 1008 IRHLKKTE-----LLSKVEALKK--------GGVLLPNDLLEKVDSINEKWELLGKTLGE 1054
             + L++ +     +  KVE  K         G     N  LEK+ +  E  + L   +  
Sbjct: 3449 TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY 3508

Query: 1055 KIQDTMA----GHSGSSPRDLLSPESGSLVRQLEVRIKELKGWL--------------RD 1096
                T         GS    LL     +    LEV+ +   G +              R 
Sbjct: 3509 LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV 3568

Query: 1097 TELFIFNSCLRQEKEG-------TMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLD 1149
             E+F   + L  E +G       T + + Q++  +    +I   +  + +    C+H+L+
Sbjct: 3569 REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE 3628

Query: 1150 DRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDL 1209
            +  T +L           + L+R  EA+  Q  +   R + +  +   TL  ++     L
Sbjct: 3629 EEGTLDL-----------LGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3677

Query: 1210 NGMSE--------DALEW---DEMDISNKLIS-----LNEESNDLDQELQPV 1245
             G+++        +AL+W    E++I N+ ++       E+ + L  +LQ V
Sbjct: 3678 KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3729



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 59/333 (17%), Positives = 135/333 (40%), Gaps = 31/333 (9%)

Query: 737  ADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLN 796
            A+  S+  S +EK  ++S        K+ Q I     ++A+ E IE     + + ++   
Sbjct: 3897 AEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR---HKALEEDIENHATDVHQAVK--- 3950

Query: 797  EAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAG 856
               ++  + T P AE   L   +++  +    +   C  K A+ ++      L    +  
Sbjct: 3951 -IGQSLSSLTSP-AEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 4008

Query: 857  LKDMLRMIASQWKEL------QRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPK 910
            + + L  +  +   +      Q  + RQH+  L   + I       D ++++ +      
Sbjct: 4009 VLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT 4068

Query: 911  AEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQE 970
               ++  ++ + D ++      Y++   +SSK         ++ +        F S Y+E
Sbjct: 4069 TGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLAT-------KFQSTYEE 4117

Query: 971  LWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGV-L 1029
            L  WL ++E  +  S     + EQ     +R   E+    ++   +L  V  + +  + L
Sbjct: 4118 LTGWLREVEEELATSGGQSPTGEQIPQFQQRQK-ELKKEVMEHRLVLDTVNEVSRALLEL 4176

Query: 1030 LPNDLLEKVDSI----NEKWELLGKTLGEKIQD 1058
            +P    E +D +    NE+++L+  T+G+++ +
Sbjct: 4177 VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 4209



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 93/526 (17%), Positives = 202/526 (38%), Gaps = 75/526 (14%)

Query: 769  QHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENW----TPPKAEMDDLKLYLETHLS 824
            + Q++ +AI  ++E    + +  +QWL    E  ++     +P K E   +K   E++ +
Sbjct: 2890 ERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET--VKAQAESNKA 2947

Query: 825  FKLNVDSHCALKEAVEEEGHQLLELIASHKAG--LKDMLRMIASQWKEL-------QRQI 875
            F   ++ +    + V+E    LL    + +     K +   + S+W+         QRQ+
Sbjct: 2948 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQL 3007

Query: 876  KRQHSWIL---RALDTIKAEILATDVSVE-------DEEGTGSPKAEVQ--LCYLEAQRD 923
            +   S +     A   ++  ++  ++ +        D     + K +VQ  L   EA+R 
Sbjct: 3008 EESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQ 3067

Query: 924  AVEQM----------------SLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSE 967
              EQ+                S     ++  S +++  E  D     S   +  +   ++
Sbjct: 3068 QHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQ 3127

Query: 968  YQELWDWLIDM-----ESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHL----KKTELLS 1018
            YQEL   L +      + L + S      E  +Q L +   +   +  L    K+ + L 
Sbjct: 3128 YQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC 3187

Query: 1019 KVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGS 1078
               ++  G   L ++L ++++++    + L     ++I    A  + +            
Sbjct: 3188 DELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST------------ 3235

Query: 1079 LVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVA 1138
              +Q +    EL+ WL D +     +C    K   +  + QLQ  +   + + Q      
Sbjct: 3236 --QQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL--QSQLQENEEFQKSLNQHSGSYE 3291

Query: 1139 SILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESE- 1197
             I+   + LL    +     + + +Q  +V L+  WE +  +    Q+RL+  M K  + 
Sbjct: 3292 VIVAEGESLL---LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY 3348

Query: 1198 --TLNVIDPGLMDLNG-MSEDALEWDEMDISNKLISLNEESNDLDQ 1240
               +  + P + D    MSE  +  D + + + L+      N++++
Sbjct: 3349 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK 3394


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 81/388 (20%), Positives = 160/388 (41%), Gaps = 56/388 (14%)

Query: 784  FVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEG 843
            F + L+  + WL +  E   N  PP AE   +K  ++     +  +D   A  + ++ EG
Sbjct: 3282 FQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEG 3341

Query: 844  HQLLELI-ASHKAGLKDMLRMIASQWKEL-----QRQIKRQHSWILRALDTIKAEILATD 897
             ++ +    + +  +   L  + S+W EL      RQ + +   +L       AE ++  
Sbjct: 3342 GRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3401

Query: 898  VSVEDEE-------GTGSPKAEVQLCYLEAQRDAVEQMSLKLY----------------- 933
            +SV +++       GT + K + Q+   +A  + +E  +  ++                 
Sbjct: 3402 LSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAE 3461

Query: 934  ----SEQYTSSSKRKEEFAD-----MSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMD 984
                SE+  S   R  E  D      + +    SN  L F  +  E+ +WL ++E  +  
Sbjct: 3462 QGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARL-FGEDEVEVLNWLAEVEDKL-- 3518

Query: 985  SHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEK 1044
               + + + +Q  L+++++  +++         +  +A+K G  LL     E+V  I EK
Sbjct: 3519 -SSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEK 3577

Query: 1045 WELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNS 1104
             + + KT    I  T    S  + R L   ++  L  + +   +EL GWLR+ E  +  S
Sbjct: 3578 LDGI-KTRYADITVT----SSKALRTL--EQARQLATKFQSTYEELTGWLREVEEELATS 3630

Query: 1105 CLRQEKEGTMNTEKQLQYFKSLCREIKQ 1132
                   G   T +Q+  F+   +E+K+
Sbjct: 3631 ------GGQSPTGEQIPQFQQRQKELKK 3652



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 102/485 (21%), Positives = 187/485 (38%), Gaps = 79/485 (16%)

Query: 760  LIQKLMQDIQH-QDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLY 818
            L + L + I H Q   E     +  F + L+E + WL    E  +   P   +   +++ 
Sbjct: 4245 LWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE 4304

Query: 819  LETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKA-GLKDMLRMIASQWKELQRQIKR 877
            L  H   K +V +H A  E V + G++LLE  A   A  L+  L  +   W+ + ++ + 
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364

Query: 878  QHSWI---LRALDTIKAEI---------LATDVSVEDEEGTGSPKAEVQL-------CYL 918
            +   +   L+      +EI         + + +S     G     A  QL         L
Sbjct: 4365 REQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQL 4424

Query: 919  EAQRDAVEQM----SLKLYSEQYTSSSKRKEEFADM--SKVHSVGS-------------N 959
            +A+ +   Q+     L L S   + S  + E+   +   K H V S             N
Sbjct: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALN 4484

Query: 960  GLLDFDSEYQELWDWLIDME---------SLVMDSHDLMMSEEQQQHLYKRYSVEMSIRH 1010
               +F +  QE  +WL   E         SL++++  L   EE +    +  +    I  
Sbjct: 4485 LATEFQNSLQEFINWLTLAEQSLNIASPPSLILNT-VLSQIEEHKVFANEVNAHRDQIIE 4543

Query: 1011 LKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRD 1070
            L +T    K  + K+  VL+ N L+    S+  +WE   K +   I+           R 
Sbjct: 4544 LDQTGNQLKFLSQKQDVVLIKNLLV----SVQSRWE---KVVQRSIE-----------RG 4585

Query: 1071 LLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEK---QLQYFKSLC 1127
                ++    +Q     K+L  WL D E     S L  E E + + +K   QL   K   
Sbjct: 4586 RSLDDARKRAKQFHEAWKKLIDWLEDAE-----SHLDSELEISNDPDKIKLQLSKHKEFQ 4640

Query: 1128 REIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTR 1187
            + +  ++    + +R  + L   +E   L  D Q +   +  +  +W+ +  ++V+ Q +
Sbjct: 4641 KTLGGKQPVYDTTIRTGRAL---KEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHK 4697

Query: 1188 LQKKM 1192
            L++ +
Sbjct: 4698 LEEAL 4702



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 103/532 (19%), Positives = 203/532 (38%), Gaps = 92/532 (17%)

Query: 775  EAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCA 834
            +A     + F    DE   WL++         P  A+++ L+  L+ +  F+ +++ H  
Sbjct: 2727 QAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSG 2786

Query: 835  LKEAVEEEGHQLLELI--ASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAE 892
              E +  EG  LL  +     K  L++ L  + + W+EL ++   + S +   +   KA+
Sbjct: 2787 SYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQ--KAQ 2844

Query: 893  ILATDVS-----VEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEF 947
                 V      +ED         + ++  L    D V+  S  L S+   +  +++   
Sbjct: 2845 KYQWHVEDLVPWIED--------CKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSL 2896

Query: 948  ADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMS 1007
             ++       +  +L   SE  E  D + D ++ +  + D +  E Q     K  S+E  
Sbjct: 2897 LEILN----SAADILINSSEADE--DGIRDEKAGINQNMDAVTEELQA----KTGSLEEM 2946

Query: 1008 IRHLKKTE-----LLSKVEALKK--------GGVLLPNDLLEKVDSINEKWELLGKTLGE 1054
             + L++ +     +  KVE  K         G     N  LEK+ +  E  + L   +  
Sbjct: 2947 TQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDY 3006

Query: 1055 KIQDTMA----GHSGSSPRDLLSPESGSLVRQLEVRIKELKGWL--------------RD 1096
                T         GS    LL     +    LEV+ +   G +              R 
Sbjct: 3007 LRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV 3066

Query: 1097 TELFIFNSCLRQEKEG-------TMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLD 1149
             E+F   + L  E +G       T + + Q++  +    +I   +  + +    C+H+L+
Sbjct: 3067 REMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLE 3126

Query: 1150 DRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDL 1209
            +  T +L           + L+R  EA+  Q  +   R + +  +   TL  ++     L
Sbjct: 3127 EEGTLDL-----------LGLKRELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKL 3175

Query: 1210 NGMSE--------DALEW---DEMDISNKLIS-----LNEESNDLDQELQPV 1245
             G+++        +AL+W    E++I N+ ++       E+ + L  +LQ V
Sbjct: 3176 KGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQMKLQQV 3227



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 59/333 (17%), Positives = 135/333 (40%), Gaps = 31/333 (9%)

Query: 737  ADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLN 796
            A+  S+  S +EK  ++S        K+ Q I     ++A+ E IE     + + ++   
Sbjct: 3395 AEPISDFLSVTEKKLANSEPVGTQTAKIQQQIIR---HKALEEDIENHATDVHQAVK--- 3448

Query: 797  EAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAG 856
               ++  + T P AE   L   +++  +    +   C  K A+ ++      L    +  
Sbjct: 3449 -IGQSLSSLTSP-AEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVE 3506

Query: 857  LKDMLRMIASQWKEL------QRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPK 910
            + + L  +  +   +      Q  + RQH+  L   + I       D ++++ +      
Sbjct: 3507 VLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQT 3566

Query: 911  AEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQE 970
               ++  ++ + D ++      Y++   +SSK         ++ +        F S Y+E
Sbjct: 3567 TGEEVLLIQEKLDGIKTR----YADITVTSSKALRTLEQARQLAT-------KFQSTYEE 3615

Query: 971  LWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGV-L 1029
            L  WL ++E  +  S     + EQ     +R   E+    ++   +L  V  + +  + L
Sbjct: 3616 LTGWLREVEEELATSGGQSPTGEQIPQFQQRQK-ELKKEVMEHRLVLDTVNEVSRALLEL 3674

Query: 1030 LPNDLLEKVDSI----NEKWELLGKTLGEKIQD 1058
            +P    E +D +    NE+++L+  T+G+++ +
Sbjct: 3675 VPWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707



 Score = 32.3 bits (72), Expect = 5.6
 Identities = 93/526 (17%), Positives = 202/526 (38%), Gaps = 75/526 (14%)

Query: 769  QHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENW----TPPKAEMDDLKLYLETHLS 824
            + Q++ +AI  ++E    + +  +QWL    E  ++     +P K E   +K   E++ +
Sbjct: 2388 ERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTET--VKAQAESNKA 2445

Query: 825  FKLNVDSHCALKEAVEEEGHQLLELIASHKAG--LKDMLRMIASQWKEL-------QRQI 875
            F   ++ +    + V+E    LL    + +     K +   + S+W+         QRQ+
Sbjct: 2446 FLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQL 2505

Query: 876  KRQHSWIL---RALDTIKAEILATDVSVE-------DEEGTGSPKAEVQ--LCYLEAQRD 923
            +   S +     A   ++  ++  ++ +        D     + K +VQ  L   EA+R 
Sbjct: 2506 EESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQ 2565

Query: 924  AVEQM----------------SLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSE 967
              EQ+                S     ++  S +++  E  D     S   +  +   ++
Sbjct: 2566 QHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQ 2625

Query: 968  YQELWDWLIDM-----ESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHL----KKTELLS 1018
            YQEL   L +      + L + S      E  +Q L +   +   +  L    K+ + L 
Sbjct: 2626 YQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLC 2685

Query: 1019 KVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGS 1078
               ++  G   L ++L ++++++    + L     ++I    A  + +            
Sbjct: 2686 DELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALAST------------ 2733

Query: 1079 LVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVA 1138
              +Q +    EL+ WL D +     +C    K   +  + QLQ  +   + + Q      
Sbjct: 2734 --QQFQQMFDELRTWLDDKQSQQAKNCPISAKLERL--QSQLQENEEFQKSLNQHSGSYE 2789

Query: 1139 SILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESE- 1197
             I+   + LL    +     + + +Q  +V L+  WE +  +    Q+RL+  M K  + 
Sbjct: 2790 VIVAEGESLL---LSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY 2846

Query: 1198 --TLNVIDPGLMDLNG-MSEDALEWDEMDISNKLISLNEESNDLDQ 1240
               +  + P + D    MSE  +  D + + + L+      N++++
Sbjct: 2847 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEK 2892


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 131/642 (20%), Positives = 249/642 (38%), Gaps = 97/642 (15%)

Query: 559  QRSWNAKLQLQSETSSSPAFTQS----------SESSVGSDNIMSPVP----LLSKHKSK 604
            Q+S   +  L  E S   AF Q           ++ +V S+++   +P    LL +H   
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106

Query: 605  K----GQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRG 660
            K    G   S   V  +GE V       EYL L   L+  +     L  + +      R 
Sbjct: 1107 KDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWE-----SRS 1161

Query: 661  ETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIES--GPLS 718
             T+     ++  E   D++        +++T L  + P  S + A +     E   G + 
Sbjct: 1162 HTLAQCLGFQ--EFQKDAKQAEAILSNQEYT-LAHLEPPDSLEAAEAGIRKFEDFLGSME 1218

Query: 719  D----ILSDEESSMPL-AGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDN 773
            +    +LS  +S   L A    Y+D+  E+    E     +  K+     L++D     N
Sbjct: 1219 NNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRD-----N 1273

Query: 774  YEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHC 833
             E     ++ F+    E   W+N+ + T+++ +  +A   +L      H +F   + SH 
Sbjct: 1274 LE-----LQNFLQNCQELTLWINDKLLTSQDVSYDEAR--NLHNKWLKHQAFVAELASHE 1326

Query: 834  ALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKR--QHSWILRALD---T 888
               E ++ EG QL++      A +   L  +   W ELQ   K   QH    R+ D    
Sbjct: 1327 GWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386

Query: 889  IKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEE-- 946
              A++     ++ED+  +  P  ++          +V +M  KL   +    + RKEE  
Sbjct: 1387 THADLNKWISAMEDQLRSDDPGKDL---------TSVNRMLAKLKRVE-DQVNVRKEELG 1436

Query: 947  --FADMSKVHSVGSNGLLDFDSEYQELWD-------WLIDMESLVMDSHDLMMSEEQQQH 997
              FA +  +   G +  L  +  + +L +        L    + +  S DL   E++   
Sbjct: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDL---EDETLW 1493

Query: 998  LYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLL---EKVDSINEKWELLGKTLGE 1054
            + +R  +  S  +      L  V+   K    L N++L    +V+ + ++ + L +    
Sbjct: 1494 VEERLPLAQSADYGTN---LQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEI 1550

Query: 1055 KIQD--TMAGHSGSSPRDLLSPESGSLVR--------QLEVRIKELKGWLRDTELFIFNS 1104
              QD     GH  SS   L    +G L R        Q  +   E + W+ + EL++ + 
Sbjct: 1551 DCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISD 1610

Query: 1105 CLRQEKEGT-------MNTEKQLQYFKSLCREIKQRRRGVAS 1139
             + +++EG        +  ++ ++ +    +++  R +G+ S
Sbjct: 1611 EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 80/349 (22%), Positives = 137/349 (39%), Gaps = 54/349 (15%)

Query: 760  LIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYL 819
            L Q L Q +Q Q++      +++ F+  LD+F  WL+   +   +   P++ + + +  L
Sbjct: 1042 LWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPES-LPEAEQLL 1100

Query: 820  ETHLSFKLNVDSHCALKEAVEEEGHQLLE--------LIASHKAGLKDMLRMIASQW--- 868
            + H   K  +D H    + V+E G ++++        L+     GL      +   W   
Sbjct: 1101 QQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESR 1160

Query: 869  ----------KELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYL 918
                      +E Q+  K+  + IL   +   A +   D S+E  E  G  K E  L  +
Sbjct: 1161 SHTLAQCLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPD-SLEAAE-AGIRKFEDFLGSM 1217

Query: 919  EAQRDAV---EQMSLKLYSEQYTSSSKRKE-------------EFADMSKVHSVGSNGLL 962
            E  RD V        KL +E    S K KE             E A  + V    +  L 
Sbjct: 1218 ENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ 1277

Query: 963  DFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTE-LLSKVE 1021
            +F    QEL  W+ D    ++ S D+   E +  H  K    +  +  L   E  L  ++
Sbjct: 1278 NFLQNCQELTLWINDK---LLTSQDVSYDEARNLH-NKWLKHQAFVAELASHEGWLENID 1333

Query: 1022 ALKKGGVLLPND------LLEKVDSINEKWELLGKTLGEKIQDTMAGHS 1064
            A  +G  L+         + +K+++++  W+ L  T  EK Q   A  S
Sbjct: 1334 A--EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 131/642 (20%), Positives = 249/642 (38%), Gaps = 97/642 (15%)

Query: 559  QRSWNAKLQLQSETSSSPAFTQS----------SESSVGSDNIMSPVP----LLSKHKSK 604
            Q+S   +  L  E S   AF Q           ++ +V S+++   +P    LL +H   
Sbjct: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106

Query: 605  K----GQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRG 660
            K    G   S   V  +GE V       EYL L   L+  +     L  + +      R 
Sbjct: 1107 KDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWE-----SRS 1161

Query: 661  ETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIES--GPLS 718
             T+     ++  E   D++        +++T L  + P  S + A +     E   G + 
Sbjct: 1162 HTLAQCLGFQ--EFQKDAKQAEAILSNQEYT-LAHLEPPDSLEAAEAGIRKFEDFLGSME 1218

Query: 719  D----ILSDEESSMPL-AGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDN 773
            +    +LS  +S   L A    Y+D+  E+    E     +  K+     L++D     N
Sbjct: 1219 NNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRD-----N 1273

Query: 774  YEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHC 833
             E     ++ F+    E   W+N+ + T+++ +  +A   +L      H +F   + SH 
Sbjct: 1274 LE-----LQNFLQNCQELTLWINDKLLTSQDVSYDEAR--NLHNKWLKHQAFVAELASHE 1326

Query: 834  ALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKR--QHSWILRALD---T 888
               E ++ EG QL++      A +   L  +   W ELQ   K   QH    R+ D    
Sbjct: 1327 GWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386

Query: 889  IKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEE-- 946
              A++     ++ED+  +  P  ++          +V +M  KL   +    + RKEE  
Sbjct: 1387 THADLNKWISAMEDQLRSDDPGKDL---------TSVNRMLAKLKRVE-DQVNVRKEELG 1436

Query: 947  --FADMSKVHSVGSNGLLDFDSEYQELWD-------WLIDMESLVMDSHDLMMSEEQQQH 997
              FA +  +   G +  L  +  + +L +        L    + +  S DL   E++   
Sbjct: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDL---EDETLW 1493

Query: 998  LYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLL---EKVDSINEKWELLGKTLGE 1054
            + +R  +  S  +      L  V+   K    L N++L    +V+ + ++ + L +    
Sbjct: 1494 VEERLPLAQSADYGTN---LQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEI 1550

Query: 1055 KIQD--TMAGHSGSSPRDLLSPESGSLVR--------QLEVRIKELKGWLRDTELFIFNS 1104
              QD     GH  SS   L    +G L R        Q  +   E + W+ + EL++ + 
Sbjct: 1551 DCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISD 1610

Query: 1105 CLRQEKEGT-------MNTEKQLQYFKSLCREIKQRRRGVAS 1139
             + +++EG        +  ++ ++ +    +++  R +G+ S
Sbjct: 1611 EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 80/349 (22%), Positives = 137/349 (39%), Gaps = 54/349 (15%)

Query: 760  LIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYL 819
            L Q L Q +Q Q++      +++ F+  LD+F  WL+   +   +   P++ + + +  L
Sbjct: 1042 LWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPES-LPEAEQLL 1100

Query: 820  ETHLSFKLNVDSHCALKEAVEEEGHQLLE--------LIASHKAGLKDMLRMIASQW--- 868
            + H   K  +D H    + V+E G ++++        L+     GL      +   W   
Sbjct: 1101 QQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESR 1160

Query: 869  ----------KELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYL 918
                      +E Q+  K+  + IL   +   A +   D S+E  E  G  K E  L  +
Sbjct: 1161 SHTLAQCLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPD-SLEAAE-AGIRKFEDFLGSM 1217

Query: 919  EAQRDAV---EQMSLKLYSEQYTSSSKRKE-------------EFADMSKVHSVGSNGLL 962
            E  RD V        KL +E    S K KE             E A  + V    +  L 
Sbjct: 1218 ENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ 1277

Query: 963  DFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTE-LLSKVE 1021
            +F    QEL  W+ D    ++ S D+   E +  H  K    +  +  L   E  L  ++
Sbjct: 1278 NFLQNCQELTLWINDK---LLTSQDVSYDEARNLH-NKWLKHQAFVAELASHEGWLENID 1333

Query: 1022 ALKKGGVLLPND------LLEKVDSINEKWELLGKTLGEKIQDTMAGHS 1064
            A  +G  L+         + +K+++++  W+ L  T  EK Q   A  S
Sbjct: 1334 A--EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 89/544 (16%)

Query: 747  SEKNESHSATKSALIQKLMQD------IQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAME 800
            +E+++ H+     +  KL+ D      I  Q   E     +  F + LDE + WL     
Sbjct: 4282 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4341

Query: 801  TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKA-GLKD 859
                  P   +   +++ L  H   + +V +H +  EAV + G+ L+E  A  +A  L++
Sbjct: 4342 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4401

Query: 860  MLRMIASQWK---ELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEG--------TGS 908
             L ++  +W+   E   Q K+Q    LR       EI      + D E          G 
Sbjct: 4402 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4461

Query: 909  PK-------AEVQLC-YLEAQRDAVEQM-------------SLKLYSEQYTSSSKRKEEF 947
            P+         +++C   EA+ +  + +             S +   +Q  ++ K K E 
Sbjct: 4462 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWES 4521

Query: 948  ADMSKVH------SVGSNGLLDFDSEYQELWDWLIDME---------SLVMDSHDLMMSE 992
             + +K++          N  ++F +  Q+  +WL   E         SL++D+  L   +
Sbjct: 4522 VE-TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT-VLFQID 4579

Query: 993  EQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTL 1052
            E +    +  S    I  L KT    K  + K+  VL+ N L+    S+  +WE + + L
Sbjct: 4580 EHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLI----SVQSRWEKVVQRL 4635

Query: 1053 GEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEG 1112
             E+      G S    R           +Q      +L  WL ++E       L  E E 
Sbjct: 4636 VER------GRSLDDAR--------KRAKQFHEAWSKLMEWLEESE-----KSLDSELEI 4676

Query: 1113 TMNTEK---QLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVN 1169
              + +K   QL   K   + +  +     +  R  + L   +E  +L  D+  +  ++  
Sbjct: 4677 ANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL---KEKTSLADDNLKLDDMLSE 4733

Query: 1170 LERRWEAIVMQAVQWQTRLQKKM---GKESETLNVIDPGLMDLN-GMSEDALEWDEMDIS 1225
            L  +W+ I  ++V+ Q +L++ +   G+ ++ L  +   L  +   ++ED     ++D+ 
Sbjct: 4734 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4793

Query: 1226 NKLI 1229
              LI
Sbjct: 4794 MNLI 4797



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 35/162 (21%), Positives = 65/162 (40%), Gaps = 9/162 (5%)

Query: 735  KYADEKSERASSSEKNESHSATKSALIQKLMQDIQ--------HQDNYEAIWEKIEGFVN 786
            K A    E  S+  K E   A  S  ++ +++  +        H  + ++       F  
Sbjct: 2737 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2796

Query: 787  KLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQL 846
               +F  WL+   E      P  A++D L+  ++ H  F   + +   + E    EG  L
Sbjct: 2797 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2856

Query: 847  L-ELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALD 887
            L +   S KA L+  L  I + W    +Q+K + + +  +L+
Sbjct: 2857 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2898



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 49/201 (24%), Positives = 81/201 (40%), Gaps = 37/201 (18%)

Query: 717  LSDILSDEE----SSMPLAGMKKYADEK-SERASSSEKNESHSATKSALIQKLMQDI--- 768
            L   L+D E    +S PL G+ + A E+ +         E+   T  +L+QK  Q +   
Sbjct: 4441 LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC 4500

Query: 769  ---------QHQDNYEAIWEKIEG------------------FVNKLDEFIQWLNEAMET 801
                     Q  +N +  WE +E                   F N L +FI WL +A +T
Sbjct: 4501 PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4560

Query: 802  TENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGL-KDM 860
                + P   +D +   ++ H  F   V+SH      +++ G  L          L K++
Sbjct: 4561 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL 4620

Query: 861  LRMIASQW-KELQRQIKRQHS 880
            L  + S+W K +QR ++R  S
Sbjct: 4621 LISVQSRWEKVVQRLVERGRS 4641



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 97/574 (16%), Positives = 221/574 (38%), Gaps = 96/574 (16%)

Query: 745  SSSEKNESHSATKSALIQKLMQDI-----QHQDNYEAIWEKIEGFVNKLDEFIQWLNEAM 799
            SS+ +  S+   K  ++ +  Q++     Q +   +    + +GF  ++++  QWL +  
Sbjct: 4390 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4449

Query: 800  ETTENWTP----PKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIA-SHK 854
                   P    P+   + L +++E   +F+   +++ +L +    +G Q+L     S +
Sbjct: 4450 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ----KGQQMLARCPKSAE 4505

Query: 855  AGLKDMLRMIASQWKELQRQIKRQHS---------------------WILRA-------- 885
              +   +  +  +W+ ++ ++  + +                     W+ +A        
Sbjct: 4506 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4565

Query: 886  -----LDTI-----KAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSE 935
                 LDT+     + ++ A +V+   E+     K    L Y   ++D V   +L L S 
Sbjct: 4566 RPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL-LISV 4624

Query: 936  QYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWL------IDMESLVMDSHDLM 989
            Q +   K  +   +  +           F   + +L +WL      +D E  + +  D +
Sbjct: 4625 Q-SRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4683

Query: 990  MSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLL--EKVDSINEKWEL 1047
             ++  Q   +K +   +  +H           +LK+   L  ++L   + +  + +KW  
Sbjct: 4684 KTQLAQ---HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKW-- 4738

Query: 1048 LGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLR 1107
                      DT+ G S      L   E+     Q    ++ L  WL   E  +      
Sbjct: 4739 ----------DTICGKSVERQNKL--EEALLFSGQFTDALQALIDWLYRVEPQLAED--- 4783

Query: 1108 QEKEGTMNTEKQL-QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLI 1166
            Q   G ++    L    K+  +E+ +R   V ++ R  + L++         D   +++ 
Sbjct: 4784 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD-----DSSWVKVQ 4838

Query: 1167 IVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEW-----DE 1221
            +  L  RWE +   ++  QTRL+  + +++E  + +   L++    +E  L +     D+
Sbjct: 4839 MQELSTRWETVCALSISKQTRLEAAL-RQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4897

Query: 1222 MDISNKLISLNEE-SNDLDQELQPVIPSLKLGET 1254
             D    LI  ++E    L+++   +  +  +G+T
Sbjct: 4898 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDT 4931



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 106/510 (20%), Positives = 202/510 (39%), Gaps = 73/510 (14%)

Query: 790  EFIQWLNEAMETTENWTPPK-------AEMDDLKLYLETHLSFKLNVDSHCA-----LKE 837
            E + WLNE  +     +           +  +L++  E  L  K NVD         LK+
Sbjct: 3564 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3623

Query: 838  AVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQ------RQIKRQHSWILRALDTIKA 891
               +E   + + + + KA  KD+ ++     K L+      R++   H  +   LD ++ 
Sbjct: 3624 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3683

Query: 892  EILATDVSVEDEEGTGSPKAEVQLCYLEAQR-----DAVEQMSLKLYS-----------E 935
            E+L+ +  V   E     +   +    EA+      D++ ++S  L             +
Sbjct: 3684 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3743

Query: 936  QYTSSSKRKEEFADM--SKVHSVGSNGLLD--FDSEYQELWDWLIDMESLVMDSHDLMMS 991
                 ++R    +D    KV  + +  L    FD        W+ + E  +M   D+ + 
Sbjct: 3744 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3803

Query: 992  EEQ---QQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELL 1048
            ++Q   Q  + K +++E+    L+  +++   + +K G  ++     E+  S+ +K   L
Sbjct: 3804 QDQTSAQLQVQKTFTMEI----LRHKDIID--DLVKSGHKIMTACSEEEKQSMKKK---L 3854

Query: 1049 GKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFN----- 1103
             K L  K  DT+     +S R L    + SLV Q     +EL  WL +T+  I       
Sbjct: 3855 DKVL--KNYDTIC--QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPA 3910

Query: 1104 ---SCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADH 1160
                 LRQ++E      + +   K     I +  +    +L L        +   + AD 
Sbjct: 3911 LEYETLRQQQEEHRQLRELIAEHKP---HIDKMNKTGPQLLELSPGEGFSIQEKYVAADT 3967

Query: 1161 QPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWD 1220
               Q I  ++++R  A+  +A+   T+   K+ +  E+L  I   L     +S +  +  
Sbjct: 3968 LYSQ-IKEDVKKRAVAL-DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4025

Query: 1221 EMDISNKLISLNEESNDLDQELQPVIPSLK 1250
            E    NK +S++ E      +LQP+  +LK
Sbjct: 4026 EQISENKNVSVDME------KLQPLYETLK 4049



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 100/456 (21%), Positives = 178/456 (39%), Gaps = 79/456 (17%)

Query: 754  SATKSALIQKLMQDIQHQDNYEAIWEKIEG------------------FVNKLDEFIQWL 795
            SA KS   Q L  D+   D+  A W+ +                    F + L+  + W+
Sbjct: 3295 SAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM 3351

Query: 796  NEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELI-ASHK 854
             +  E   N  PP AE   +K  ++     +  +D   +  E ++ EG ++      + K
Sbjct: 3352 VDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADK 3411

Query: 855  AGLKDMLRMIASQWKEL-------QRQIK------RQHSWILRALDTIKAEILATDVSVE 901
              +   L ++ S+W+ L        RQ++      +Q    L  L+     I    V+ E
Sbjct: 3412 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE 3471

Query: 902  DEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLY-------SEQYTSSSKRK---EEFADMS 951
               GT + K E Q+   +A  D +   +  L+       S +  SS + K   +   D S
Sbjct: 3472 -PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3530

Query: 952  KV-------HSVGSNGLLD--------FDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQ 996
            +V        S   + LL         F  +  EL +WL ++   +     L + +   +
Sbjct: 3531 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKL---SKLSVQDYSTE 3587

Query: 997  HLYKRYSVEMSIRHLKKTELLSKV---EALKKGGVLLPNDLLEKVDSINEKWELLGKTLG 1053
             L+K+ S    +R L++  LL K    +AL  G  LL     ++V  I +K E + K   
Sbjct: 3588 GLWKQQS---ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KARY 3643

Query: 1054 EKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGT 1113
            + I       + +  + L       L R+L    +EL  WL   E+ +  S   Q  +G 
Sbjct: 3644 KDITKLSTDVAKTLEQAL------QLARRLHSTHEELCTWLDKVEVELL-SYETQVLKGE 3696

Query: 1114 MNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLD 1149
              ++ Q++  K L +E K  +  + S+  +   LL+
Sbjct: 3697 EASQAQMRP-KELKKEAKNNKALLDSLNEVSSALLE 3731



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 51/292 (17%), Positives = 111/292 (38%), Gaps = 59/292 (20%)

Query: 771  QDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVD 830
            ++   A+ +K +    +L +   W+++A+  +  +      + D    L+  LS  L V 
Sbjct: 2650 KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVS 2709

Query: 831  SHCALKEAVEEEGHQLLELIASHKAGLK-------DMLRMIASQWKELQRQIKRQHSWIL 883
            +H        E   ++ + I   K  +K       D+  ++  ++  L+ ++ RQ   IL
Sbjct: 2710 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSRQLEGIL 2767

Query: 884  RALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKR 943
            ++   ++                   KAE  + +L++   +  Q        Q    +K+
Sbjct: 2768 KSFKDVEQ------------------KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2809

Query: 944  KEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYS 1003
            +E+    +K H + +                L  +ESL+ D  D   +   Q H+Y++  
Sbjct: 2810 EEQ----NKSHPISAK---------------LDVLESLIKDHKDFSKTLTAQSHMYEKTI 2850

Query: 1004 VEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEK 1055
             E          LL K +  +K  + L      ++++I   W+   K + E+
Sbjct: 2851 AE-------GENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKER 2889



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 42/226 (18%), Positives = 84/226 (37%), Gaps = 19/226 (8%)

Query: 779  EKIEGFVNKL----DEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCA 834
            E+ +  VN+     +E   WL E          P  E + L+   E H   +  +  H  
Sbjct: 3876 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 3935

Query: 835  LKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRAL-------D 887
              + + + G QLLEL       +++      + + +++  +K++   +  A+       D
Sbjct: 3936 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3995

Query: 888  TIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEF 947
             I   + + +  VE      S  AEV+    +   +    + ++     Y +  +R EE 
Sbjct: 3996 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 948  ADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEE 993
                    +  +G  D D   + + D L  M  +  + H L+   E
Sbjct: 4056 --------IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 40/177 (22%), Positives = 77/177 (43%), Gaps = 33/177 (18%)

Query: 720  ILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWE 779
            +L+ EE+S  L G+K+  +  S++ +                 KL+      D  +A  E
Sbjct: 3181 MLATEETSPDLVGIKRDLEALSKQCN-----------------KLL------DRAQAREE 3217

Query: 780  KIEGFVNKLDEFIQWLNE-------AMETTENWTPPKAEMDDLKLYLETHLSF-KLNVDS 831
            ++EG + +L+EF   L E       A E  E+  P   E + +   L     F K  ++ 
Sbjct: 3218 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3277

Query: 832  HCALKEAVEEEGHQLLELIASHKA--GLKDMLRMIASQWKELQRQIKRQHSWILRAL 886
                ++ V   G  L++  A   +  GL+  L  + ++WK L +++ ++ + +  AL
Sbjct: 3278 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3334


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 89/544 (16%)

Query: 747  SEKNESHSATKSALIQKLMQD------IQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAME 800
            +E+++ H+     +  KL+ D      I  Q   E     +  F + LDE + WL     
Sbjct: 4293 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4352

Query: 801  TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKA-GLKD 859
                  P   +   +++ L  H   + +V +H +  EAV + G+ L+E  A  +A  L++
Sbjct: 4353 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4412

Query: 860  MLRMIASQWK---ELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEG--------TGS 908
             L ++  +W+   E   Q K+Q    LR       EI      + D E          G 
Sbjct: 4413 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4472

Query: 909  PK-------AEVQLC-YLEAQRDAVEQM-------------SLKLYSEQYTSSSKRKEEF 947
            P+         +++C   EA+ +  + +             S +   +Q  ++ K K E 
Sbjct: 4473 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWES 4532

Query: 948  ADMSKVH------SVGSNGLLDFDSEYQELWDWLIDME---------SLVMDSHDLMMSE 992
             + +K++          N  ++F +  Q+  +WL   E         SL++D+  L   +
Sbjct: 4533 VE-TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT-VLFQID 4590

Query: 993  EQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTL 1052
            E +    +  S    I  L KT    K  + K+  VL+ N L+    S+  +WE + + L
Sbjct: 4591 EHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLI----SVQSRWEKVVQRL 4646

Query: 1053 GEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEG 1112
             E+      G S    R           +Q      +L  WL ++E       L  E E 
Sbjct: 4647 VER------GRSLDDAR--------KRAKQFHEAWSKLMEWLEESE-----KSLDSELEI 4687

Query: 1113 TMNTEK---QLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVN 1169
              + +K   QL   K   + +  +     +  R  + L   +E  +L  D+  +  ++  
Sbjct: 4688 ANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL---KEKTSLADDNLKLDDMLSE 4744

Query: 1170 LERRWEAIVMQAVQWQTRLQKKM---GKESETLNVIDPGLMDLN-GMSEDALEWDEMDIS 1225
            L  +W+ I  ++V+ Q +L++ +   G+ ++ L  +   L  +   ++ED     ++D+ 
Sbjct: 4745 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4804

Query: 1226 NKLI 1229
              LI
Sbjct: 4805 MNLI 4808



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 35/162 (21%), Positives = 65/162 (40%), Gaps = 9/162 (5%)

Query: 735  KYADEKSERASSSEKNESHSATKSALIQKLMQDIQ--------HQDNYEAIWEKIEGFVN 786
            K A    E  S+  K E   A  S  ++ +++  +        H  + ++       F  
Sbjct: 2748 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807

Query: 787  KLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQL 846
               +F  WL+   E      P  A++D L+  ++ H  F   + +   + E    EG  L
Sbjct: 2808 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2867

Query: 847  L-ELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALD 887
            L +   S KA L+  L  I + W    +Q+K + + +  +L+
Sbjct: 2868 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2909



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 49/201 (24%), Positives = 81/201 (40%), Gaps = 37/201 (18%)

Query: 717  LSDILSDEE----SSMPLAGMKKYADEK-SERASSSEKNESHSATKSALIQKLMQDI--- 768
            L   L+D E    +S PL G+ + A E+ +         E+   T  +L+QK  Q +   
Sbjct: 4452 LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC 4511

Query: 769  ---------QHQDNYEAIWEKIEG------------------FVNKLDEFIQWLNEAMET 801
                     Q  +N +  WE +E                   F N L +FI WL +A +T
Sbjct: 4512 PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4571

Query: 802  TENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGL-KDM 860
                + P   +D +   ++ H  F   V+SH      +++ G  L          L K++
Sbjct: 4572 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL 4631

Query: 861  LRMIASQW-KELQRQIKRQHS 880
            L  + S+W K +QR ++R  S
Sbjct: 4632 LISVQSRWEKVVQRLVERGRS 4652



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 97/574 (16%), Positives = 221/574 (38%), Gaps = 96/574 (16%)

Query: 745  SSSEKNESHSATKSALIQKLMQDI-----QHQDNYEAIWEKIEGFVNKLDEFIQWLNEAM 799
            SS+ +  S+   K  ++ +  Q++     Q +   +    + +GF  ++++  QWL +  
Sbjct: 4401 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4460

Query: 800  ETTENWTP----PKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIA-SHK 854
                   P    P+   + L +++E   +F+   +++ +L +    +G Q+L     S +
Sbjct: 4461 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ----KGQQMLARCPKSAE 4516

Query: 855  AGLKDMLRMIASQWKELQRQIKRQHS---------------------WILRA-------- 885
              +   +  +  +W+ ++ ++  + +                     W+ +A        
Sbjct: 4517 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4576

Query: 886  -----LDTI-----KAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSE 935
                 LDT+     + ++ A +V+   E+     K    L Y   ++D V   +L L S 
Sbjct: 4577 RPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL-LISV 4635

Query: 936  QYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWL------IDMESLVMDSHDLM 989
            Q +   K  +   +  +           F   + +L +WL      +D E  + +  D +
Sbjct: 4636 Q-SRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4694

Query: 990  MSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLL--EKVDSINEKWEL 1047
             ++  Q   +K +   +  +H           +LK+   L  ++L   + +  + +KW  
Sbjct: 4695 KTQLAQ---HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKW-- 4749

Query: 1048 LGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLR 1107
                      DT+ G S      L   E+     Q    ++ L  WL   E  +      
Sbjct: 4750 ----------DTICGKSVERQNKL--EEALLFSGQFTDALQALIDWLYRVEPQLAED--- 4794

Query: 1108 QEKEGTMNTEKQL-QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLI 1166
            Q   G ++    L    K+  +E+ +R   V ++ R  + L++         D   +++ 
Sbjct: 4795 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD-----DSSWVKVQ 4849

Query: 1167 IVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEW-----DE 1221
            +  L  RWE +   ++  QTRL+  + +++E  + +   L++    +E  L +     D+
Sbjct: 4850 MQELSTRWETVCALSISKQTRLEAAL-RQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4908

Query: 1222 MDISNKLISLNEE-SNDLDQELQPVIPSLKLGET 1254
             D    LI  ++E    L+++   +  +  +G+T
Sbjct: 4909 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDT 4942



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 106/510 (20%), Positives = 202/510 (39%), Gaps = 73/510 (14%)

Query: 790  EFIQWLNEAMETTENWTPPK-------AEMDDLKLYLETHLSFKLNVDSHCA-----LKE 837
            E + WLNE  +     +           +  +L++  E  L  K NVD         LK+
Sbjct: 3575 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3634

Query: 838  AVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQ------RQIKRQHSWILRALDTIKA 891
               +E   + + + + KA  KD+ ++     K L+      R++   H  +   LD ++ 
Sbjct: 3635 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3694

Query: 892  EILATDVSVEDEEGTGSPKAEVQLCYLEAQR-----DAVEQMSLKLYS-----------E 935
            E+L+ +  V   E     +   +    EA+      D++ ++S  L             +
Sbjct: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3754

Query: 936  QYTSSSKRKEEFADM--SKVHSVGSNGLLD--FDSEYQELWDWLIDMESLVMDSHDLMMS 991
                 ++R    +D    KV  + +  L    FD        W+ + E  +M   D+ + 
Sbjct: 3755 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3814

Query: 992  EEQ---QQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELL 1048
            ++Q   Q  + K +++E+    L+  +++   + +K G  ++     E+  S+ +K   L
Sbjct: 3815 QDQTSAQLQVQKTFTMEI----LRHKDIID--DLVKSGHKIMTACSEEEKQSMKKK---L 3865

Query: 1049 GKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFN----- 1103
             K L  K  DT+     +S R L    + SLV Q     +EL  WL +T+  I       
Sbjct: 3866 DKVL--KNYDTIC--QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPA 3921

Query: 1104 ---SCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADH 1160
                 LRQ++E      + +   K     I +  +    +L L        +   + AD 
Sbjct: 3922 LEYETLRQQQEEHRQLRELIAEHKP---HIDKMNKTGPQLLELSPGEGFSIQEKYVAADT 3978

Query: 1161 QPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWD 1220
               Q I  ++++R  A+  +A+   T+   K+ +  E+L  I   L     +S +  +  
Sbjct: 3979 LYSQ-IKEDVKKRAVAL-DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4036

Query: 1221 EMDISNKLISLNEESNDLDQELQPVIPSLK 1250
            E    NK +S++ E      +LQP+  +LK
Sbjct: 4037 EQISENKNVSVDME------KLQPLYETLK 4060



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 100/456 (21%), Positives = 178/456 (39%), Gaps = 79/456 (17%)

Query: 754  SATKSALIQKLMQDIQHQDNYEAIWEKIEG------------------FVNKLDEFIQWL 795
            SA KS   Q L  D+   D+  A W+ +                    F + L+  + W+
Sbjct: 3306 SAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM 3362

Query: 796  NEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELI-ASHK 854
             +  E   N  PP AE   +K  ++     +  +D   +  E ++ EG ++      + K
Sbjct: 3363 VDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADK 3422

Query: 855  AGLKDMLRMIASQWKEL-------QRQIK------RQHSWILRALDTIKAEILATDVSVE 901
              +   L ++ S+W+ L        RQ++      +Q    L  L+     I    V+ E
Sbjct: 3423 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE 3482

Query: 902  DEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLY-------SEQYTSSSKRK---EEFADMS 951
               GT + K E Q+   +A  D +   +  L+       S +  SS + K   +   D S
Sbjct: 3483 -PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3541

Query: 952  KV-------HSVGSNGLLD--------FDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQ 996
            +V        S   + LL         F  +  EL +WL ++   +     L + +   +
Sbjct: 3542 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKL---SKLSVQDYSTE 3598

Query: 997  HLYKRYSVEMSIRHLKKTELLSKV---EALKKGGVLLPNDLLEKVDSINEKWELLGKTLG 1053
             L+K+ S    +R L++  LL K    +AL  G  LL     ++V  I +K E + K   
Sbjct: 3599 GLWKQQS---ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KARY 3654

Query: 1054 EKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGT 1113
            + I       + +  + L       L R+L    +EL  WL   E+ +  S   Q  +G 
Sbjct: 3655 KDITKLSTDVAKTLEQAL------QLARRLHSTHEELCTWLDKVEVELL-SYETQVLKGE 3707

Query: 1114 MNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLD 1149
              ++ Q++  K L +E K  +  + S+  +   LL+
Sbjct: 3708 EASQAQMRP-KELKKEAKNNKALLDSLNEVSSALLE 3742



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 51/292 (17%), Positives = 111/292 (38%), Gaps = 59/292 (20%)

Query: 771  QDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVD 830
            ++   A+ +K +    +L +   W+++A+  +  +      + D    L+  LS  L V 
Sbjct: 2661 KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVS 2720

Query: 831  SHCALKEAVEEEGHQLLELIASHKAGLK-------DMLRMIASQWKELQRQIKRQHSWIL 883
            +H        E   ++ + I   K  +K       D+  ++  ++  L+ ++ RQ   IL
Sbjct: 2721 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSRQLEGIL 2778

Query: 884  RALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKR 943
            ++   ++                   KAE  + +L++   +  Q        Q    +K+
Sbjct: 2779 KSFKDVEQ------------------KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2820

Query: 944  KEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYS 1003
            +E+    +K H + +                L  +ESL+ D  D   +   Q H+Y++  
Sbjct: 2821 EEQ----NKSHPISAK---------------LDVLESLIKDHKDFSKTLTAQSHMYEKTI 2861

Query: 1004 VEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEK 1055
             E          LL K +  +K  + L      ++++I   W+   K + E+
Sbjct: 2862 AE-------GENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKER 2900



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 42/226 (18%), Positives = 84/226 (37%), Gaps = 19/226 (8%)

Query: 779  EKIEGFVNKL----DEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCA 834
            E+ +  VN+     +E   WL E          P  E + L+   E H   +  +  H  
Sbjct: 3887 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 3946

Query: 835  LKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRAL-------D 887
              + + + G QLLEL       +++      + + +++  +K++   +  A+       D
Sbjct: 3947 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4006

Query: 888  TIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEF 947
             I   + + +  VE      S  AEV+    +   +    + ++     Y +  +R EE 
Sbjct: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 948  ADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEE 993
                    +  +G  D D   + + D L  M  +  + H L+   E
Sbjct: 4067 --------IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 40/177 (22%), Positives = 77/177 (43%), Gaps = 33/177 (18%)

Query: 720  ILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWE 779
            +L+ EE+S  L G+K+  +  S++ +                 KL+      D  +A  E
Sbjct: 3192 MLATEETSPDLVGIKRDLEALSKQCN-----------------KLL------DRAQAREE 3228

Query: 780  KIEGFVNKLDEFIQWLNE-------AMETTENWTPPKAEMDDLKLYLETHLSF-KLNVDS 831
            ++EG + +L+EF   L E       A E  E+  P   E + +   L     F K  ++ 
Sbjct: 3229 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3288

Query: 832  HCALKEAVEEEGHQLLELIASHKA--GLKDMLRMIASQWKELQRQIKRQHSWILRAL 886
                ++ V   G  L++  A   +  GL+  L  + ++WK L +++ ++ + +  AL
Sbjct: 3289 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3345


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 89/544 (16%)

Query: 747  SEKNESHSATKSALIQKLMQD------IQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAME 800
            +E+++ H+     +  KL+ D      I  Q   E     +  F + LDE + WL     
Sbjct: 4431 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4490

Query: 801  TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKA-GLKD 859
                  P   +   +++ L  H   + +V +H +  EAV + G+ L+E  A  +A  L++
Sbjct: 4491 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4550

Query: 860  MLRMIASQWK---ELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEG--------TGS 908
             L ++  +W+   E   Q K+Q    LR       EI      + D E          G 
Sbjct: 4551 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4610

Query: 909  PK-------AEVQLC-YLEAQRDAVEQM-------------SLKLYSEQYTSSSKRKEEF 947
            P+         +++C   EA+ +  + +             S +   +Q  ++ K K E 
Sbjct: 4611 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWES 4670

Query: 948  ADMSKVH------SVGSNGLLDFDSEYQELWDWLIDME---------SLVMDSHDLMMSE 992
             + +K++          N  ++F +  Q+  +WL   E         SL++D+  L   +
Sbjct: 4671 VE-TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT-VLFQID 4728

Query: 993  EQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTL 1052
            E +    +  S    I  L KT    K  + K+  VL+ N L+    S+  +WE + + L
Sbjct: 4729 EHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLI----SVQSRWEKVVQRL 4784

Query: 1053 GEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEG 1112
             E+      G S    R           +Q      +L  WL ++E       L  E E 
Sbjct: 4785 VER------GRSLDDAR--------KRAKQFHEAWSKLMEWLEESE-----KSLDSELEI 4825

Query: 1113 TMNTEK---QLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVN 1169
              + +K   QL   K   + +  +     +  R  + L   +E  +L  D+  +  ++  
Sbjct: 4826 ANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL---KEKTSLADDNLKLDDMLSE 4882

Query: 1170 LERRWEAIVMQAVQWQTRLQKKM---GKESETLNVIDPGLMDLN-GMSEDALEWDEMDIS 1225
            L  +W+ I  ++V+ Q +L++ +   G+ ++ L  +   L  +   ++ED     ++D+ 
Sbjct: 4883 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4942

Query: 1226 NKLI 1229
              LI
Sbjct: 4943 MNLI 4946



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 35/162 (21%), Positives = 65/162 (40%), Gaps = 9/162 (5%)

Query: 735  KYADEKSERASSSEKNESHSATKSALIQKLMQDIQ--------HQDNYEAIWEKIEGFVN 786
            K A    E  S+  K E   A  S  ++ +++  +        H  + ++       F  
Sbjct: 2886 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2945

Query: 787  KLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQL 846
               +F  WL+   E      P  A++D L+  ++ H  F   + +   + E    EG  L
Sbjct: 2946 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 3005

Query: 847  L-ELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALD 887
            L +   S KA L+  L  I + W    +Q+K + + +  +L+
Sbjct: 3006 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 3047



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 49/201 (24%), Positives = 81/201 (40%), Gaps = 37/201 (18%)

Query: 717  LSDILSDEE----SSMPLAGMKKYADEK-SERASSSEKNESHSATKSALIQKLMQDI--- 768
            L   L+D E    +S PL G+ + A E+ +         E+   T  +L+QK  Q +   
Sbjct: 4590 LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC 4649

Query: 769  ---------QHQDNYEAIWEKIEG------------------FVNKLDEFIQWLNEAMET 801
                     Q  +N +  WE +E                   F N L +FI WL +A +T
Sbjct: 4650 PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4709

Query: 802  TENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGL-KDM 860
                + P   +D +   ++ H  F   V+SH      +++ G  L          L K++
Sbjct: 4710 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL 4769

Query: 861  LRMIASQW-KELQRQIKRQHS 880
            L  + S+W K +QR ++R  S
Sbjct: 4770 LISVQSRWEKVVQRLVERGRS 4790



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 97/574 (16%), Positives = 221/574 (38%), Gaps = 96/574 (16%)

Query: 745  SSSEKNESHSATKSALIQKLMQDI-----QHQDNYEAIWEKIEGFVNKLDEFIQWLNEAM 799
            SS+ +  S+   K  ++ +  Q++     Q +   +    + +GF  ++++  QWL +  
Sbjct: 4539 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4598

Query: 800  ETTENWTP----PKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIA-SHK 854
                   P    P+   + L +++E   +F+   +++ +L +    +G Q+L     S +
Sbjct: 4599 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ----KGQQMLARCPKSAE 4654

Query: 855  AGLKDMLRMIASQWKELQRQIKRQHS---------------------WILRA-------- 885
              +   +  +  +W+ ++ ++  + +                     W+ +A        
Sbjct: 4655 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4714

Query: 886  -----LDTI-----KAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSE 935
                 LDT+     + ++ A +V+   E+     K    L Y   ++D V   +L L S 
Sbjct: 4715 RPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL-LISV 4773

Query: 936  QYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWL------IDMESLVMDSHDLM 989
            Q +   K  +   +  +           F   + +L +WL      +D E  + +  D +
Sbjct: 4774 Q-SRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4832

Query: 990  MSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLL--EKVDSINEKWEL 1047
             ++  Q   +K +   +  +H           +LK+   L  ++L   + +  + +KW  
Sbjct: 4833 KTQLAQ---HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKW-- 4887

Query: 1048 LGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLR 1107
                      DT+ G S      L   E+     Q    ++ L  WL   E  +      
Sbjct: 4888 ----------DTICGKSVERQNKL--EEALLFSGQFTDALQALIDWLYRVEPQLAED--- 4932

Query: 1108 QEKEGTMNTEKQL-QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLI 1166
            Q   G ++    L    K+  +E+ +R   V ++ R  + L++         D   +++ 
Sbjct: 4933 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD-----DSSWVKVQ 4987

Query: 1167 IVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEW-----DE 1221
            +  L  RWE +   ++  QTRL+  + +++E  + +   L++    +E  L +     D+
Sbjct: 4988 MQELSTRWETVCALSISKQTRLEAAL-RQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 5046

Query: 1222 MDISNKLISLNEE-SNDLDQELQPVIPSLKLGET 1254
             D    LI  ++E    L+++   +  +  +G+T
Sbjct: 5047 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDT 5080



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 106/510 (20%), Positives = 202/510 (39%), Gaps = 73/510 (14%)

Query: 790  EFIQWLNEAMETTENWTPPK-------AEMDDLKLYLETHLSFKLNVDSHCA-----LKE 837
            E + WLNE  +     +           +  +L++  E  L  K NVD         LK+
Sbjct: 3713 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3772

Query: 838  AVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQ------RQIKRQHSWILRALDTIKA 891
               +E   + + + + KA  KD+ ++     K L+      R++   H  +   LD ++ 
Sbjct: 3773 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3832

Query: 892  EILATDVSVEDEEGTGSPKAEVQLCYLEAQR-----DAVEQMSLKLYS-----------E 935
            E+L+ +  V   E     +   +    EA+      D++ ++S  L             +
Sbjct: 3833 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3892

Query: 936  QYTSSSKRKEEFADM--SKVHSVGSNGLLD--FDSEYQELWDWLIDMESLVMDSHDLMMS 991
                 ++R    +D    KV  + +  L    FD        W+ + E  +M   D+ + 
Sbjct: 3893 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3952

Query: 992  EEQ---QQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELL 1048
            ++Q   Q  + K +++E+    L+  +++   + +K G  ++     E+  S+ +K   L
Sbjct: 3953 QDQTSAQLQVQKTFTMEI----LRHKDIID--DLVKSGHKIMTACSEEEKQSMKKK---L 4003

Query: 1049 GKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFN----- 1103
             K L  K  DT+     +S R L    + SLV Q     +EL  WL +T+  I       
Sbjct: 4004 DKVL--KNYDTIC--QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPA 4059

Query: 1104 ---SCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADH 1160
                 LRQ++E      + +   K     I +  +    +L L        +   + AD 
Sbjct: 4060 LEYETLRQQQEEHRQLRELIAEHKP---HIDKMNKTGPQLLELSPGEGFSIQEKYVAADT 4116

Query: 1161 QPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWD 1220
               Q I  ++++R  A+  +A+   T+   K+ +  E+L  I   L     +S +  +  
Sbjct: 4117 LYSQ-IKEDVKKRAVAL-DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 4174

Query: 1221 EMDISNKLISLNEESNDLDQELQPVIPSLK 1250
            E    NK +S++ E      +LQP+  +LK
Sbjct: 4175 EQISENKNVSVDME------KLQPLYETLK 4198



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 100/456 (21%), Positives = 178/456 (39%), Gaps = 79/456 (17%)

Query: 754  SATKSALIQKLMQDIQHQDNYEAIWEKIEG------------------FVNKLDEFIQWL 795
            SA KS   Q L  D+   D+  A W+ +                    F + L+  + W+
Sbjct: 3444 SAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM 3500

Query: 796  NEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELI-ASHK 854
             +  E   N  PP AE   +K  ++     +  +D   +  E ++ EG ++      + K
Sbjct: 3501 VDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADK 3560

Query: 855  AGLKDMLRMIASQWKEL-------QRQIK------RQHSWILRALDTIKAEILATDVSVE 901
              +   L ++ S+W+ L        RQ++      +Q    L  L+     I    V+ E
Sbjct: 3561 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE 3620

Query: 902  DEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLY-------SEQYTSSSKRK---EEFADMS 951
               GT + K E Q+   +A  D +   +  L+       S +  SS + K   +   D S
Sbjct: 3621 -PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3679

Query: 952  KV-------HSVGSNGLLD--------FDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQ 996
            +V        S   + LL         F  +  EL +WL ++   +     L + +   +
Sbjct: 3680 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKL---SKLSVQDYSTE 3736

Query: 997  HLYKRYSVEMSIRHLKKTELLSKV---EALKKGGVLLPNDLLEKVDSINEKWELLGKTLG 1053
             L+K+ S    +R L++  LL K    +AL  G  LL     ++V  I +K E + K   
Sbjct: 3737 GLWKQQS---ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KARY 3792

Query: 1054 EKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGT 1113
            + I       + +  + L       L R+L    +EL  WL   E+ +  S   Q  +G 
Sbjct: 3793 KDITKLSTDVAKTLEQAL------QLARRLHSTHEELCTWLDKVEVELL-SYETQVLKGE 3845

Query: 1114 MNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLD 1149
              ++ Q++  K L +E K  +  + S+  +   LL+
Sbjct: 3846 EASQAQMRP-KELKKEAKNNKALLDSLNEVSSALLE 3880



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 51/292 (17%), Positives = 111/292 (38%), Gaps = 59/292 (20%)

Query: 771  QDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVD 830
            ++   A+ +K +    +L +   W+++A+  +  +      + D    L+  LS  L V 
Sbjct: 2799 KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVS 2858

Query: 831  SHCALKEAVEEEGHQLLELIASHKAGLK-------DMLRMIASQWKELQRQIKRQHSWIL 883
            +H        E   ++ + I   K  +K       D+  ++  ++  L+ ++ RQ   IL
Sbjct: 2859 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSRQLEGIL 2916

Query: 884  RALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKR 943
            ++   ++                   KAE  + +L++   +  Q        Q    +K+
Sbjct: 2917 KSFKDVEQ------------------KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2958

Query: 944  KEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYS 1003
            +E+    +K H + +                L  +ESL+ D  D   +   Q H+Y++  
Sbjct: 2959 EEQ----NKSHPISAK---------------LDVLESLIKDHKDFSKTLTAQSHMYEKTI 2999

Query: 1004 VEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEK 1055
             E          LL K +  +K  + L      ++++I   W+   K + E+
Sbjct: 3000 AE-------GENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKER 3038



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 42/226 (18%), Positives = 84/226 (37%), Gaps = 19/226 (8%)

Query: 779  EKIEGFVNKL----DEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCA 834
            E+ +  VN+     +E   WL E          P  E + L+   E H   +  +  H  
Sbjct: 4025 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 4084

Query: 835  LKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRAL-------D 887
              + + + G QLLEL       +++      + + +++  +K++   +  A+       D
Sbjct: 4085 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 4144

Query: 888  TIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEF 947
             I   + + +  VE      S  AEV+    +   +    + ++     Y +  +R EE 
Sbjct: 4145 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 948  ADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEE 993
                    +  +G  D D   + + D L  M  +  + H L+   E
Sbjct: 4205 --------IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 40/177 (22%), Positives = 77/177 (43%), Gaps = 33/177 (18%)

Query: 720  ILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWE 779
            +L+ EE+S  L G+K+  +  S++ +                 KL+      D  +A  E
Sbjct: 3330 MLATEETSPDLVGIKRDLEALSKQCN-----------------KLL------DRAQAREE 3366

Query: 780  KIEGFVNKLDEFIQWLNE-------AMETTENWTPPKAEMDDLKLYLETHLSF-KLNVDS 831
            ++EG + +L+EF   L E       A E  E+  P   E + +   L     F K  ++ 
Sbjct: 3367 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3426

Query: 832  HCALKEAVEEEGHQLLELIASHKA--GLKDMLRMIASQWKELQRQIKRQHSWILRAL 886
                ++ V   G  L++  A   +  GL+  L  + ++WK L +++ ++ + +  AL
Sbjct: 3427 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3483


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 89/544 (16%)

Query: 747  SEKNESHSATKSALIQKLMQD------IQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAME 800
            +E+++ H+     +  KL+ D      I  Q   E     +  F + LDE + WL     
Sbjct: 4253 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 4312

Query: 801  TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKA-GLKD 859
                  P   +   +++ L  H   + +V +H +  EAV + G+ L+E  A  +A  L++
Sbjct: 4313 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4372

Query: 860  MLRMIASQWK---ELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEG--------TGS 908
             L ++  +W+   E   Q K+Q    LR       EI      + D E          G 
Sbjct: 4373 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4432

Query: 909  PK-------AEVQLC-YLEAQRDAVEQM-------------SLKLYSEQYTSSSKRKEEF 947
            P+         +++C   EA+ +  + +             S +   +Q  ++ K K E 
Sbjct: 4433 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWES 4492

Query: 948  ADMSKVH------SVGSNGLLDFDSEYQELWDWLIDME---------SLVMDSHDLMMSE 992
             + +K++          N  ++F +  Q+  +WL   E         SL++D+  L   +
Sbjct: 4493 VE-TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT-VLFQID 4550

Query: 993  EQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTL 1052
            E +    +  S    I  L KT    K  + K+  VL+ N L+    S+  +WE + + L
Sbjct: 4551 EHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLI----SVQSRWEKVVQRL 4606

Query: 1053 GEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEG 1112
             E+      G S    R           +Q      +L  WL ++E       L  E E 
Sbjct: 4607 VER------GRSLDDAR--------KRAKQFHEAWSKLMEWLEESE-----KSLDSELEI 4647

Query: 1113 TMNTEK---QLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVN 1169
              + +K   QL   K   + +  +     +  R  + L   +E  +L  D+  +  ++  
Sbjct: 4648 ANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL---KEKTSLADDNLKLDDMLSE 4704

Query: 1170 LERRWEAIVMQAVQWQTRLQKKM---GKESETLNVIDPGLMDLN-GMSEDALEWDEMDIS 1225
            L  +W+ I  ++V+ Q +L++ +   G+ ++ L  +   L  +   ++ED     ++D+ 
Sbjct: 4705 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4764

Query: 1226 NKLI 1229
              LI
Sbjct: 4765 MNLI 4768



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 35/162 (21%), Positives = 65/162 (40%), Gaps = 9/162 (5%)

Query: 735  KYADEKSERASSSEKNESHSATKSALIQKLMQDIQ--------HQDNYEAIWEKIEGFVN 786
            K A    E  S+  K E   A  S  ++ +++  +        H  + ++       F  
Sbjct: 2708 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2767

Query: 787  KLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQL 846
               +F  WL+   E      P  A++D L+  ++ H  F   + +   + E    EG  L
Sbjct: 2768 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2827

Query: 847  L-ELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALD 887
            L +   S KA L+  L  I + W    +Q+K + + +  +L+
Sbjct: 2828 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2869



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 49/201 (24%), Positives = 81/201 (40%), Gaps = 37/201 (18%)

Query: 717  LSDILSDEE----SSMPLAGMKKYADEK-SERASSSEKNESHSATKSALIQKLMQDI--- 768
            L   L+D E    +S PL G+ + A E+ +         E+   T  +L+QK  Q +   
Sbjct: 4412 LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC 4471

Query: 769  ---------QHQDNYEAIWEKIEG------------------FVNKLDEFIQWLNEAMET 801
                     Q  +N +  WE +E                   F N L +FI WL +A +T
Sbjct: 4472 PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4531

Query: 802  TENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGL-KDM 860
                + P   +D +   ++ H  F   V+SH      +++ G  L          L K++
Sbjct: 4532 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL 4591

Query: 861  LRMIASQW-KELQRQIKRQHS 880
            L  + S+W K +QR ++R  S
Sbjct: 4592 LISVQSRWEKVVQRLVERGRS 4612



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 97/574 (16%), Positives = 221/574 (38%), Gaps = 96/574 (16%)

Query: 745  SSSEKNESHSATKSALIQKLMQDI-----QHQDNYEAIWEKIEGFVNKLDEFIQWLNEAM 799
            SS+ +  S+   K  ++ +  Q++     Q +   +    + +GF  ++++  QWL +  
Sbjct: 4361 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4420

Query: 800  ETTENWTP----PKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIA-SHK 854
                   P    P+   + L +++E   +F+   +++ +L +    +G Q+L     S +
Sbjct: 4421 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ----KGQQMLARCPKSAE 4476

Query: 855  AGLKDMLRMIASQWKELQRQIKRQHS---------------------WILRA-------- 885
              +   +  +  +W+ ++ ++  + +                     W+ +A        
Sbjct: 4477 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4536

Query: 886  -----LDTI-----KAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSE 935
                 LDT+     + ++ A +V+   E+     K    L Y   ++D V   +L L S 
Sbjct: 4537 RPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL-LISV 4595

Query: 936  QYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWL------IDMESLVMDSHDLM 989
            Q +   K  +   +  +           F   + +L +WL      +D E  + +  D +
Sbjct: 4596 Q-SRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4654

Query: 990  MSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLL--EKVDSINEKWEL 1047
             ++  Q   +K +   +  +H           +LK+   L  ++L   + +  + +KW  
Sbjct: 4655 KTQLAQ---HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKW-- 4709

Query: 1048 LGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLR 1107
                      DT+ G S      L   E+     Q    ++ L  WL   E  +      
Sbjct: 4710 ----------DTICGKSVERQNKL--EEALLFSGQFTDALQALIDWLYRVEPQLAED--- 4754

Query: 1108 QEKEGTMNTEKQL-QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLI 1166
            Q   G ++    L    K+  +E+ +R   V ++ R  + L++         D   +++ 
Sbjct: 4755 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD-----DSSWVKVQ 4809

Query: 1167 IVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEW-----DE 1221
            +  L  RWE +   ++  QTRL+  + +++E  + +   L++    +E  L +     D+
Sbjct: 4810 MQELSTRWETVCALSISKQTRLEAAL-RQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4868

Query: 1222 MDISNKLISLNEE-SNDLDQELQPVIPSLKLGET 1254
             D    LI  ++E    L+++   +  +  +G+T
Sbjct: 4869 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDT 4902



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 106/510 (20%), Positives = 202/510 (39%), Gaps = 73/510 (14%)

Query: 790  EFIQWLNEAMETTENWTPPK-------AEMDDLKLYLETHLSFKLNVDSHCA-----LKE 837
            E + WLNE  +     +           +  +L++  E  L  K NVD         LK+
Sbjct: 3535 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3594

Query: 838  AVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQ------RQIKRQHSWILRALDTIKA 891
               +E   + + + + KA  KD+ ++     K L+      R++   H  +   LD ++ 
Sbjct: 3595 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3654

Query: 892  EILATDVSVEDEEGTGSPKAEVQLCYLEAQR-----DAVEQMSLKLYS-----------E 935
            E+L+ +  V   E     +   +    EA+      D++ ++S  L             +
Sbjct: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3714

Query: 936  QYTSSSKRKEEFADM--SKVHSVGSNGLLD--FDSEYQELWDWLIDMESLVMDSHDLMMS 991
                 ++R    +D    KV  + +  L    FD        W+ + E  +M   D+ + 
Sbjct: 3715 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3774

Query: 992  EEQ---QQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELL 1048
            ++Q   Q  + K +++E+    L+  +++   + +K G  ++     E+  S+ +K   L
Sbjct: 3775 QDQTSAQLQVQKTFTMEI----LRHKDIID--DLVKSGHKIMTACSEEEKQSMKKK---L 3825

Query: 1049 GKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFN----- 1103
             K L  K  DT+     +S R L    + SLV Q     +EL  WL +T+  I       
Sbjct: 3826 DKVL--KNYDTIC--QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPA 3881

Query: 1104 ---SCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADH 1160
                 LRQ++E      + +   K     I +  +    +L L        +   + AD 
Sbjct: 3882 LEYETLRQQQEEHRQLRELIAEHKP---HIDKMNKTGPQLLELSPGEGFSIQEKYVAADT 3938

Query: 1161 QPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWD 1220
               Q I  ++++R  A+  +A+   T+   K+ +  E+L  I   L     +S +  +  
Sbjct: 3939 LYSQ-IKEDVKKRAVAL-DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 3996

Query: 1221 EMDISNKLISLNEESNDLDQELQPVIPSLK 1250
            E    NK +S++ E      +LQP+  +LK
Sbjct: 3997 EQISENKNVSVDME------KLQPLYETLK 4020



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 100/456 (21%), Positives = 178/456 (39%), Gaps = 79/456 (17%)

Query: 754  SATKSALIQKLMQDIQHQDNYEAIWEKIEG------------------FVNKLDEFIQWL 795
            SA KS   Q L  D+   D+  A W+ +                    F + L+  + W+
Sbjct: 3266 SAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM 3322

Query: 796  NEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELI-ASHK 854
             +  E   N  PP AE   +K  ++     +  +D   +  E ++ EG ++      + K
Sbjct: 3323 VDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADK 3382

Query: 855  AGLKDMLRMIASQWKEL-------QRQIK------RQHSWILRALDTIKAEILATDVSVE 901
              +   L ++ S+W+ L        RQ++      +Q    L  L+     I    V+ E
Sbjct: 3383 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE 3442

Query: 902  DEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLY-------SEQYTSSSKRK---EEFADMS 951
               GT + K E Q+   +A  D +   +  L+       S +  SS + K   +   D S
Sbjct: 3443 -PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3501

Query: 952  KV-------HSVGSNGLLD--------FDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQ 996
            +V        S   + LL         F  +  EL +WL ++   +     L + +   +
Sbjct: 3502 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKL---SKLSVQDYSTE 3558

Query: 997  HLYKRYSVEMSIRHLKKTELLSKV---EALKKGGVLLPNDLLEKVDSINEKWELLGKTLG 1053
             L+K+ S    +R L++  LL K    +AL  G  LL     ++V  I +K E + K   
Sbjct: 3559 GLWKQQS---ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KARY 3614

Query: 1054 EKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGT 1113
            + I       + +  + L       L R+L    +EL  WL   E+ +  S   Q  +G 
Sbjct: 3615 KDITKLSTDVAKTLEQAL------QLARRLHSTHEELCTWLDKVEVELL-SYETQVLKGE 3667

Query: 1114 MNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLD 1149
              ++ Q++  K L +E K  +  + S+  +   LL+
Sbjct: 3668 EASQAQMRP-KELKKEAKNNKALLDSLNEVSSALLE 3702



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 51/292 (17%), Positives = 111/292 (38%), Gaps = 59/292 (20%)

Query: 771  QDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVD 830
            ++   A+ +K +    +L +   W+++A+  +  +      + D    L+  LS  L V 
Sbjct: 2621 KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVS 2680

Query: 831  SHCALKEAVEEEGHQLLELIASHKAGLK-------DMLRMIASQWKELQRQIKRQHSWIL 883
            +H        E   ++ + I   K  +K       D+  ++  ++  L+ ++ RQ   IL
Sbjct: 2681 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSRQLEGIL 2738

Query: 884  RALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKR 943
            ++   ++                   KAE  + +L++   +  Q        Q    +K+
Sbjct: 2739 KSFKDVEQ------------------KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2780

Query: 944  KEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYS 1003
            +E+    +K H + +                L  +ESL+ D  D   +   Q H+Y++  
Sbjct: 2781 EEQ----NKSHPISAK---------------LDVLESLIKDHKDFSKTLTAQSHMYEKTI 2821

Query: 1004 VEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEK 1055
             E          LL K +  +K  + L      ++++I   W+   K + E+
Sbjct: 2822 AE-------GENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKER 2860



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 42/226 (18%), Positives = 84/226 (37%), Gaps = 19/226 (8%)

Query: 779  EKIEGFVNKL----DEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCA 834
            E+ +  VN+     +E   WL E          P  E + L+   E H   +  +  H  
Sbjct: 3847 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 3906

Query: 835  LKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRAL-------D 887
              + + + G QLLEL       +++      + + +++  +K++   +  A+       D
Sbjct: 3907 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3966

Query: 888  TIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEF 947
             I   + + +  VE      S  AEV+    +   +    + ++     Y +  +R EE 
Sbjct: 3967 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026

Query: 948  ADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEE 993
                    +  +G  D D   + + D L  M  +  + H L+   E
Sbjct: 4027 --------IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 40/177 (22%), Positives = 77/177 (43%), Gaps = 33/177 (18%)

Query: 720  ILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWE 779
            +L+ EE+S  L G+K+  +  S++ +                 KL+      D  +A  E
Sbjct: 3152 MLATEETSPDLVGIKRDLEALSKQCN-----------------KLL------DRAQAREE 3188

Query: 780  KIEGFVNKLDEFIQWLNE-------AMETTENWTPPKAEMDDLKLYLETHLSF-KLNVDS 831
            ++EG + +L+EF   L E       A E  E+  P   E + +   L     F K  ++ 
Sbjct: 3189 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 3248

Query: 832  HCALKEAVEEEGHQLLELIASHKA--GLKDMLRMIASQWKELQRQIKRQHSWILRAL 886
                ++ V   G  L++  A   +  GL+  L  + ++WK L +++ ++ + +  AL
Sbjct: 3249 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 3305


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 89/544 (16%)

Query: 747  SEKNESHSATKSALIQKLMQD------IQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAME 800
            +E+++ H+     +  KL+ D      I  Q   E     +  F + LDE + WL     
Sbjct: 3927 TEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEG 3986

Query: 801  TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKA-GLKD 859
                  P   +   +++ L  H   + +V +H +  EAV + G+ L+E  A  +A  L++
Sbjct: 3987 LLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQN 4046

Query: 860  MLRMIASQWK---ELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEG--------TGS 908
             L ++  +W+   E   Q K+Q    LR       EI      + D E          G 
Sbjct: 4047 KLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGL 4106

Query: 909  PK-------AEVQLC-YLEAQRDAVEQM-------------SLKLYSEQYTSSSKRKEEF 947
            P+         +++C   EA+ +  + +             S +   +Q  ++ K K E 
Sbjct: 4107 PETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWES 4166

Query: 948  ADMSKVH------SVGSNGLLDFDSEYQELWDWLIDME---------SLVMDSHDLMMSE 992
             + +K++          N  ++F +  Q+  +WL   E         SL++D+  L   +
Sbjct: 4167 VE-TKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDT-VLFQID 4224

Query: 993  EQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTL 1052
            E +    +  S    I  L KT    K  + K+  VL+ N L+    S+  +WE + + L
Sbjct: 4225 EHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLI----SVQSRWEKVVQRL 4280

Query: 1053 GEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEG 1112
             E+      G S    R           +Q      +L  WL ++E       L  E E 
Sbjct: 4281 VER------GRSLDDAR--------KRAKQFHEAWSKLMEWLEESE-----KSLDSELEI 4321

Query: 1113 TMNTEK---QLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVN 1169
              + +K   QL   K   + +  +     +  R  + L   +E  +L  D+  +  ++  
Sbjct: 4322 ANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL---KEKTSLADDNLKLDDMLSE 4378

Query: 1170 LERRWEAIVMQAVQWQTRLQKKM---GKESETLNVIDPGLMDLN-GMSEDALEWDEMDIS 1225
            L  +W+ I  ++V+ Q +L++ +   G+ ++ L  +   L  +   ++ED     ++D+ 
Sbjct: 4379 LRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLV 4438

Query: 1226 NKLI 1229
              LI
Sbjct: 4439 MNLI 4442



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 35/162 (21%), Positives = 65/162 (40%), Gaps = 9/162 (5%)

Query: 735  KYADEKSERASSSEKNESHSATKSALIQKLMQDIQ--------HQDNYEAIWEKIEGFVN 786
            K A    E  S+  K E   A  S  ++ +++  +        H  + ++       F  
Sbjct: 2382 KVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2441

Query: 787  KLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQL 846
               +F  WL+   E      P  A++D L+  ++ H  F   + +   + E    EG  L
Sbjct: 2442 MSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENL 2501

Query: 847  L-ELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALD 887
            L +   S KA L+  L  I + W    +Q+K + + +  +L+
Sbjct: 2502 LLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE 2543



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 49/201 (24%), Positives = 81/201 (40%), Gaps = 37/201 (18%)

Query: 717  LSDILSDEE----SSMPLAGMKKYADEK-SERASSSEKNESHSATKSALIQKLMQDI--- 768
            L   L+D E    +S PL G+ + A E+ +         E+   T  +L+QK  Q +   
Sbjct: 4086 LQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARC 4145

Query: 769  ---------QHQDNYEAIWEKIEG------------------FVNKLDEFIQWLNEAMET 801
                     Q  +N +  WE +E                   F N L +FI WL +A +T
Sbjct: 4146 PKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQT 4205

Query: 802  TENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGL-KDM 860
                + P   +D +   ++ H  F   V+SH      +++ G  L          L K++
Sbjct: 4206 LNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL 4265

Query: 861  LRMIASQW-KELQRQIKRQHS 880
            L  + S+W K +QR ++R  S
Sbjct: 4266 LISVQSRWEKVVQRLVERGRS 4286



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 97/574 (16%), Positives = 221/574 (38%), Gaps = 96/574 (16%)

Query: 745  SSSEKNESHSATKSALIQKLMQDI-----QHQDNYEAIWEKIEGFVNKLDEFIQWLNEAM 799
            SS+ +  S+   K  ++ +  Q++     Q +   +    + +GF  ++++  QWL +  
Sbjct: 4035 SSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTE 4094

Query: 800  ETTENWTP----PKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIA-SHK 854
                   P    P+   + L +++E   +F+   +++ +L +    +G Q+L     S +
Sbjct: 4095 RHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQ----KGQQMLARCPKSAE 4150

Query: 855  AGLKDMLRMIASQWKELQRQIKRQHS---------------------WILRA-------- 885
              +   +  +  +W+ ++ ++  + +                     W+ +A        
Sbjct: 4151 TNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVAS 4210

Query: 886  -----LDTI-----KAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSE 935
                 LDT+     + ++ A +V+   E+     K    L Y   ++D V   +L L S 
Sbjct: 4211 RPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNL-LISV 4269

Query: 936  QYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWL------IDMESLVMDSHDLM 989
            Q +   K  +   +  +           F   + +L +WL      +D E  + +  D +
Sbjct: 4270 Q-SRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKI 4328

Query: 990  MSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLL--EKVDSINEKWEL 1047
             ++  Q   +K +   +  +H           +LK+   L  ++L   + +  + +KW  
Sbjct: 4329 KTQLAQ---HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKW-- 4383

Query: 1048 LGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLR 1107
                      DT+ G S      L   E+     Q    ++ L  WL   E  +      
Sbjct: 4384 ----------DTICGKSVERQNKL--EEALLFSGQFTDALQALIDWLYRVEPQLAED--- 4428

Query: 1108 QEKEGTMNTEKQL-QYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLI 1166
            Q   G ++    L    K+  +E+ +R   V ++ R  + L++         D   +++ 
Sbjct: 4429 QPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRD-----DSSWVKVQ 4483

Query: 1167 IVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEW-----DE 1221
            +  L  RWE +   ++  QTRL+  + +++E  + +   L++    +E  L +     D+
Sbjct: 4484 MQELSTRWETVCALSISKQTRLEAAL-RQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4542

Query: 1222 MDISNKLISLNEE-SNDLDQELQPVIPSLKLGET 1254
             D    LI  ++E    L+++   +  +  +G+T
Sbjct: 4543 EDALRTLIDQHKEFMKKLEEKRAELNKATTMGDT 4576



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 106/510 (20%), Positives = 202/510 (39%), Gaps = 73/510 (14%)

Query: 790  EFIQWLNEAMETTENWTPPK-------AEMDDLKLYLETHLSFKLNVDSHCA-----LKE 837
            E + WLNE  +     +           +  +L++  E  L  K NVD         LK+
Sbjct: 3209 ELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQ 3268

Query: 838  AVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQ------RQIKRQHSWILRALDTIKA 891
               +E   + + + + KA  KD+ ++     K L+      R++   H  +   LD ++ 
Sbjct: 3269 TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEV 3328

Query: 892  EILATDVSVEDEEGTGSPKAEVQLCYLEAQR-----DAVEQMSLKLYS-----------E 935
            E+L+ +  V   E     +   +    EA+      D++ ++S  L             +
Sbjct: 3329 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3388

Query: 936  QYTSSSKRKEEFADM--SKVHSVGSNGLLD--FDSEYQELWDWLIDMESLVMDSHDLMMS 991
                 ++R    +D    KV  + +  L    FD        W+ + E  +M   D+ + 
Sbjct: 3389 MVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLE 3448

Query: 992  EEQ---QQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELL 1048
            ++Q   Q  + K +++E+    L+  +++   + +K G  ++     E+  S+ +K   L
Sbjct: 3449 QDQTSAQLQVQKTFTMEI----LRHKDIID--DLVKSGHKIMTACSEEEKQSMKKK---L 3499

Query: 1049 GKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFN----- 1103
             K L  K  DT+     +S R L    + SLV Q     +EL  WL +T+  I       
Sbjct: 3500 DKVL--KNYDTIC--QINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPA 3555

Query: 1104 ---SCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADH 1160
                 LRQ++E      + +   K     I +  +    +L L        +   + AD 
Sbjct: 3556 LEYETLRQQQEEHRQLRELIAEHKP---HIDKMNKTGPQLLELSPGEGFSIQEKYVAADT 3612

Query: 1161 QPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWD 1220
               Q I  ++++R  A+  +A+   T+   K+ +  E+L  I   L     +S +  +  
Sbjct: 3613 LYSQ-IKEDVKKRAVAL-DEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIK 3670

Query: 1221 EMDISNKLISLNEESNDLDQELQPVIPSLK 1250
            E    NK +S++ E      +LQP+  +LK
Sbjct: 3671 EQISENKNVSVDME------KLQPLYETLK 3694



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 100/456 (21%), Positives = 178/456 (39%), Gaps = 79/456 (17%)

Query: 754  SATKSALIQKLMQDIQHQDNYEAIWEKIEG------------------FVNKLDEFIQWL 795
            SA KS   Q L  D+   D+  A W+ +                    F + L+  + W+
Sbjct: 2940 SAAKSTSTQGLEHDL---DDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWM 2996

Query: 796  NEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELI-ASHK 854
             +  E   N  PP AE   +K  ++     +  +D   +  E ++ EG ++      + K
Sbjct: 2997 VDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADK 3056

Query: 855  AGLKDMLRMIASQWKEL-------QRQIK------RQHSWILRALDTIKAEILATDVSVE 901
              +   L ++ S+W+ L        RQ++      +Q    L  L+     I    V+ E
Sbjct: 3057 VKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCE 3116

Query: 902  DEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLY-------SEQYTSSSKRK---EEFADMS 951
               GT + K E Q+   +A  D +   +  L+       S +  SS + K   +   D S
Sbjct: 3117 -PIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFS 3175

Query: 952  KV-------HSVGSNGLLD--------FDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQ 996
            +V        S   + LL         F  +  EL +WL ++   +     L + +   +
Sbjct: 3176 QVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKL---SKLSVQDYSTE 3232

Query: 997  HLYKRYSVEMSIRHLKKTELLSKV---EALKKGGVLLPNDLLEKVDSINEKWELLGKTLG 1053
             L+K+ S    +R L++  LL K    +AL  G  LL     ++V  I +K E + K   
Sbjct: 3233 GLWKQQS---ELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAI-KARY 3288

Query: 1054 EKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGT 1113
            + I       + +  + L       L R+L    +EL  WL   E+ +  S   Q  +G 
Sbjct: 3289 KDITKLSTDVAKTLEQAL------QLARRLHSTHEELCTWLDKVEVELL-SYETQVLKGE 3341

Query: 1114 MNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLD 1149
              ++ Q++  K L +E K  +  + S+  +   LL+
Sbjct: 3342 EASQAQMRP-KELKKEAKNNKALLDSLNEVSSALLE 3376



 Score = 37.0 bits (84), Expect = 0.23
 Identities = 51/292 (17%), Positives = 111/292 (38%), Gaps = 59/292 (20%)

Query: 771  QDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVD 830
            ++   A+ +K +    +L +   W+++A+  +  +      + D    L+  LS  L V 
Sbjct: 2295 KEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVS 2354

Query: 831  SHCALKEAVEEEGHQLLELIASHKAGLK-------DMLRMIASQWKELQRQIKRQHSWIL 883
            +H        E   ++ + I   K  +K       D+  ++  ++  L+ ++ RQ   IL
Sbjct: 2355 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEY--LKAELSRQLEGIL 2412

Query: 884  RALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKR 943
            ++   ++                   KAE  + +L++   +  Q        Q    +K+
Sbjct: 2413 KSFKDVEQ------------------KAENHVQHLQSACASSHQFQQMSRDFQAWLDTKK 2454

Query: 944  KEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYS 1003
            +E+    +K H + +                L  +ESL+ D  D   +   Q H+Y++  
Sbjct: 2455 EEQ----NKSHPISAK---------------LDVLESLIKDHKDFSKTLTAQSHMYEKTI 2495

Query: 1004 VEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEK 1055
             E          LL K +  +K  + L      ++++I   W+   K + E+
Sbjct: 2496 AE-------GENLLLKTQGSEKAALQL------QLNTIKTNWDTFNKQVKER 2534



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 42/226 (18%), Positives = 84/226 (37%), Gaps = 19/226 (8%)

Query: 779  EKIEGFVNKL----DEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCA 834
            E+ +  VN+     +E   WL E          P  E + L+   E H   +  +  H  
Sbjct: 3521 ERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKP 3580

Query: 835  LKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRAL-------D 887
              + + + G QLLEL       +++      + + +++  +K++   +  A+       D
Sbjct: 3581 HIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD 3640

Query: 888  TIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEF 947
             I   + + +  VE      S  AEV+    +   +    + ++     Y +  +R EE 
Sbjct: 3641 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700

Query: 948  ADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEE 993
                    +  +G  D D   + + D L  M  +  + H L+   E
Sbjct: 3701 --------IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 40/177 (22%), Positives = 77/177 (43%), Gaps = 33/177 (18%)

Query: 720  ILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWE 779
            +L+ EE+S  L G+K+  +  S++ +                 KL+      D  +A  E
Sbjct: 2826 MLATEETSPDLVGIKRDLEALSKQCN-----------------KLL------DRAQAREE 2862

Query: 780  KIEGFVNKLDEFIQWLNE-------AMETTENWTPPKAEMDDLKLYLETHLSF-KLNVDS 831
            ++EG + +L+EF   L E       A E  E+  P   E + +   L     F K  ++ 
Sbjct: 2863 QVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEP 2922

Query: 832  HCALKEAVEEEGHQLLELIASHKA--GLKDMLRMIASQWKELQRQIKRQHSWILRAL 886
                ++ V   G  L++  A   +  GL+  L  + ++WK L +++ ++ + +  AL
Sbjct: 2923 LQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEAL 2979


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 52.0 bits (123), Expect = 7e-06
 Identities = 132/660 (20%), Positives = 271/660 (41%), Gaps = 87/660 (13%)

Query: 637  LKQTEVLALKLENLTKLLPQKPRGETIQNIDDW--ELSEMNSDSEIYPTYH---VKKKHT 691
            L Q + L+ K++ L+K      +   ++ +DDW  + SE    ++   T H   VK+   
Sbjct: 1411 LDQVQDLSFKVDTLSK-----EKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI 1465

Query: 692  RLGRVSPSS--SSDIASSLGESIESGP-----LSDILSDEESSMPLAGMKKYADEKSERA 744
            +L   S  +    +  + L E ++        L   + D++S M         + KS+ A
Sbjct: 1466 QLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTA 1525

Query: 745  SSSEKNESHSATKSALIQKL---------MQDIQHQDNYEAIWEKIEGFVNKLDEFIQWL 795
               E  E H   K+  I+ L          +DI+H++  + + +  +    + D  ++  
Sbjct: 1526 RIMEL-EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL-QHFQELGEEKDNRVKEA 1583

Query: 796  NEAMETTENWT-PPKAEMDDLKLYLE-THLSFKLNVDSHCALKEAVEEEGH-QLLELIAS 852
             E + T EN     KAE++  K  LE  +LS K   +   AL++ +E E   +L EL   
Sbjct: 1584 EEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRK 1643

Query: 853  HKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEE--GTGSPK 910
             +  +  + + + SQ +E + Q K+     L  L+T K +    +V + +E+     S +
Sbjct: 1644 AEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT-KLQEREREVHILEEKLKSVESSQ 1702

Query: 911  AEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQE 970
            +E  +    A+  A        Y+EQ  + S+   +     K+  +  N           
Sbjct: 1703 SETLIVPRSAKNVAA-------YTEQEEADSQGCVQKTYEEKISVLQRN----------- 1744

Query: 971  LWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLL 1030
                L + E L+       + +E+++ +   +  EM  ++ ++   L   EA +     +
Sbjct: 1745 ----LTEKEKLLQ-----RVGQEKEETVSSHF--EMRCQYQERLIKLEHAEAKQHEDQSM 1793

Query: 1031 PNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKEL 1090
               L E+++  N+K+ L+     EK      G +    +  L      + + L+   KEL
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEK----EGGKNNIQAKQNLENVFDDVQKTLQE--KEL 1847

Query: 1091 KGWLRDTELFIFNSCLRQEKEGTMNTEKQL--QYFKSLCREIKQRRRGVASIL------R 1142
               + + ++   +SCL ++KE      ++L  +Y K    +    R     +L      +
Sbjct: 1848 TCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK 1907

Query: 1143 LCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVI 1202
               HL+  +   N+ A H  ++  +   ER  + +  + V+ Q  L+    +  + L ++
Sbjct: 1908 SKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEIL 1967

Query: 1203 DPGLMDLNGMSEDALEWDEMDISNKLIS-----LNEESNDLDQELQPVIPSLKLGETSNE 1257
                 + +   E+ ++ ++ D+  K  S     + E +  L Q+ Q +  ++K  ET N+
Sbjct: 1968 K---KEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK--ETINK 2022



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 89/423 (21%), Positives = 181/423 (42%), Gaps = 41/423 (9%)

Query: 733  MKKYADEKSERASSSEKNESHSATKS-ALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEF 791
            +K   DE+ +    + + E  S  +  + +++ + D+  + + E I +  +    +L   
Sbjct: 433  LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARK 492

Query: 792  IQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIA 851
             Q L + ++T E     +   + +K+ LE   S  L +      +E  ++E   L EL  
Sbjct: 493  EQELTKKLQTRE-----REFQEQMKVALEKSQSEYLKIS-----QEKEQQESLALEELEL 542

Query: 852  SHKAGL---KDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGS 908
              KA L   ++ LR +  + +  + +I    S + ++L   K +     V +E E+   +
Sbjct: 543  QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHN 602

Query: 909  P-------KAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGL 961
                    K + +L  L+ Q+DA+    L++  +QY +  ++  E  +  K   +    +
Sbjct: 603  KEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEI 662

Query: 962  LDFDSEYQELWDWLIDMESLVMDSHDL-MMSEEQQQHLYKRYSVEMSIRHLK------KT 1014
            + F +  +E+ +    +E L +   +L  +S E  + L  R+ +E  +  LK      K 
Sbjct: 663  I-FQAHIEEMNE--KTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQ 719

Query: 1015 ELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAG-HSGSSPRDLLS 1073
            EL +K++  K       N   ++VDSI ++ E+  +   + ++D +         RD   
Sbjct: 720  ELEAKMDEQK-------NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHL 772

Query: 1074 PESGSLVRQLEVRIKELKGWLR--DTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIK 1131
             E  + V  LE  IK  +G L+    +L +F S      E T   E+QL   +    +++
Sbjct: 773  KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832

Query: 1132 QRR 1134
              R
Sbjct: 833  TER 835



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 93/455 (20%), Positives = 188/455 (41%), Gaps = 39/455 (8%)

Query: 510 TPKRGTGSGKQAKNTKSSAVPNGELSYTSKAIEGPQTNSASTSSLEPCNQRSWNAKLQLQ 569
           TP R +G  +         VP+ E  + S   E    +S+  S +   ++ S N +L L 
Sbjct: 50  TPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLN-RLDLD 108

Query: 570 SETSS-SPAFTQSSESS--VGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYG 626
           S T+S  P     SE+   VG+ + ++   L+   + ++ + S  S+  +  E+V A+  
Sbjct: 109 SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLI--QRLRRMERSLSSYRGKYSELVTAYQM 166

Query: 627 -SDEYLALPSHLKQTEVLALK--LENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPT 683
              E   L   L Q++  +L+   E   +L   +   + +Q   D  L E +    +  T
Sbjct: 167 LQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQT 226

Query: 684 -YHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSE 742
              + K+  R G +    + D+   L    +  P +++ + EE+  P +  +   ++ + 
Sbjct: 227 QVSLLKQRLRNGPM----NVDVLKPLP---QLEPQAEVFTKEEN--PESDGEPVVEDGTS 277

Query: 743 RASSSEKNESHSATKSALIQKLMQDIQ-HQDNYEAIWEKIEGFVNKLDEFIQWLNEAMET 801
              + E  +     +  L+++  + IQ H++    +  + E    +LDE +Q L +  + 
Sbjct: 278 -VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDL 336

Query: 802 -TENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDM 860
                T    ++ D K  +E     +L  D    + E  + + H+ LE+     A L+  
Sbjct: 337 HMAEKTKLITQLRDAKNLIE-----QLEQDKGMVIAE-TKRQMHETLEMKEEEIAQLRSR 390

Query: 861 LRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEA 920
           ++ + +Q +EL+ Q ++        L+       A   + + EE     KAE     ++ 
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEK------ALSTAQKTEEARRKLKAE-----MDE 439

Query: 921 QRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHS 955
           Q   +E+ S +         S+ K+E  D+ K  S
Sbjct: 440 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSS 474



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 46/222 (20%), Positives = 93/222 (41%), Gaps = 17/222 (7%)

Query: 730  LAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDI--QHQDNYEAIWEKIEGFVNK 787
            L+ M+   ++   + + +E+ +     +   +QK ++ +  +HQ   E + ++ +    +
Sbjct: 1918 LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD---QE 1974

Query: 788  LDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLL 847
             +E I+   E +E   N T     +  L     T L+ K   +    +KE + +      
Sbjct: 1975 REEKIKQEQEDLELKHNST-----LKQLMREFNTQLAQK-EQELEMTIKETINKAQEVEA 2028

Query: 848  ELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTG 907
            EL+ SH+     +L+ IA +  +L+R  KR    +    + + A++      +E+ +   
Sbjct: 2029 ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKY 2088

Query: 908  SPKAEVQLCYLEAQRDAVEQMSLKLYSEQYT---SSSKRKEE 946
              K E +        D V  M L+    Q T   S SK KE+
Sbjct: 2089 QQKLEQE---ENPGNDNVTIMELQTQLAQKTTLISDSKLKEQ 2127



 Score = 32.7 bits (73), Expect = 4.3
 Identities = 110/542 (20%), Positives = 211/542 (38%), Gaps = 58/542 (10%)

Query: 750  NESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPK 809
            N+    TK  L++K    +Q ++  +   E +   ++  ++ I  LNE  ET       K
Sbjct: 896  NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK 955

Query: 810  AEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQL-----------LELIASHKAGLK 858
             E    K         K  +D    LK+ +E    +L           LE+  ++ AG+ 
Sbjct: 956  MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015

Query: 859  DMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYL 918
            D +  + +  KE    +   H   L             DV    E+       E+Q  + 
Sbjct: 1016 DAVSRLETNQKEQIESLTEVHRREL------------NDVISIWEKKLNQQAEELQEIH- 1062

Query: 919  EAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDM 978
            E Q    EQ   +L  +      +++E   +++ +   G    +  D+   EL + L   
Sbjct: 1063 EIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG----VKQDTTLNELQEQLKQK 1118

Query: 979  ESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKV 1038
             + V   + L   E + +   ++  V+++    + T L  ++  LK    +L  +   KV
Sbjct: 1119 SAHV---NSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK----MLAEEDKRKV 1171

Query: 1039 DSINEKWELLGKTLGEKIQDTMAGH--SGSSPRDL---LSPESGSLVRQLEVRIKELKGW 1093
              +  K     KT  E+ Q   + H  S  S  D        S  L  QL++  K+ +  
Sbjct: 1172 SELTSKL----KTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEAL 1227

Query: 1094 L--RDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCRE-IKQRRRGVASILRLCQHLLDD 1150
            L  +  EL   +S    +    ++     Q+  +  +E +  +   V+ +    + L ++
Sbjct: 1228 LEAKTNELINISS---SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEE 1284

Query: 1151 RETCNLNADHQPMQL-IIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDL 1209
            + T N++      QL    N  +  +A +   V  +  LQK+ G + +  +  +  +  L
Sbjct: 1285 QNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQL 1344

Query: 1210 -NGMSE--DALEWDEMDISNKLI---SLNEESNDLDQELQPVIP-SLKLGETSNEDPGYD 1262
               +SE  +A+   + ++  K +   SL+++  DL+ +LQ  I  S K    S+    YD
Sbjct: 1345 KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYD 1404

Query: 1263 EE 1264
            EE
Sbjct: 1405 EE 1406


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 125/641 (19%), Positives = 253/641 (39%), Gaps = 100/641 (15%)

Query: 633  LPSHLKQTEVLALKLENLTKL--LPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKH 690
            L  ++++ E   L+ +   K+  +  K   ETI   D+   S     ++I  T  ++K H
Sbjct: 1219 LRGYIREIEATGLQTKEELKIAHIHLKEHQETI---DELRRSVSEKTAQIINTQDLEKSH 1275

Query: 691  TRLGRVSPSSSSDI-----ASSLGESIESGPLSDILSDEES---SMPLAGMK-------- 734
            T+L    P    +         + E+ E+    ++L+++ +   S  LA ++        
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335

Query: 735  KYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWE---KIEGFVNKLDEF 791
            K+ + + E  S +++ ++    K AL      +++H    E I E   KI+   +K ++ 
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEAL------EVKHDQLKEHIRETLAKIQESQSKQEQS 1389

Query: 792  IQWLNEAMETT------ENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEG-- 843
            +    +  ETT      E + P  + +  L++ +E     K   +SH  +K   +E+   
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSAL--LRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447

Query: 844  HQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDE 903
             +L E++ S    LK+ ++ I ++  E + ++K  H  +    +TI    L  ++S ++ 
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE--LRVNLSEKET 1505

Query: 904  EGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLD 963
            E +   K       LEA  D ++    ++Y ++   + K+  E  +              
Sbjct: 1506 EISTIQK------QLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559

Query: 964  FDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEAL 1023
             DS  Q +   ++++ + + +S + +    +++   KR    + I   +  E   ++ A 
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1619

Query: 1024 KKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQL 1083
             K             +S  ++++ L  T   + Q+ M              E   L  Q 
Sbjct: 1620 MK-------------ESQEKEYQFLKMTAVNETQEKMC-------------EIEHLKEQF 1653

Query: 1084 EVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRL 1143
            E +   L+    +TE       L +  E   +  K+    +S+   +K  R  +   L  
Sbjct: 1654 ETQKLNLEN--IETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL-- 1709

Query: 1144 CQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVID 1203
                   RET   + + Q  +L IV+         M   + Q  + K  G  SE  N I 
Sbjct: 1710 -------RETITRDLEKQE-ELKIVH---------MHLKEHQETIDKLRGIVSEKTNEIS 1752

Query: 1204 PGLMDLNGMSEDALEWDEMDISNKL----ISLNEESNDLDQ 1240
                DL   S DAL+  ++ I  +L    + L E+   +D+
Sbjct: 1753 NMQKDLE-HSNDALKAQDLKIQEELRIAHMHLKEQQETIDK 1792



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 117/588 (19%), Positives = 239/588 (40%), Gaps = 85/588 (14%)

Query: 638  KQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVS 697
            KQ E +  KL+N  + + +K     I+ I           SE+    +  K+     +  
Sbjct: 1512 KQLEAINDKLQNKIQEIYEKEEQFNIKQI-----------SEVQEKVNELKQFKEHRKAK 1560

Query: 698  PSSSSDIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATK 757
             S+   I S + E      L++ L + +  + +   +K   ++ + A   E+++    TK
Sbjct: 1561 DSALQSIESKMLE------LTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTK 1614

Query: 758  SALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKL 817
              + +  M++ Q ++        +     K+ E I+ L E  ET +       E ++++L
Sbjct: 1615 EIVAK--MKESQEKEYQFLKMTAVNETQEKMCE-IEHLKEQFET-QKLNLENIETENIRL 1670

Query: 818  YLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKR 877
                H + +   +     KE   ++   + E +   +  LK+ LR   ++  E Q ++K 
Sbjct: 1671 TQILHENLE---EMRSVTKE--RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKI 1725

Query: 878  QHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQY 937
             H  +    +TI  + L   VS +  E +   K       LE   DA++   LK+  E  
Sbjct: 1726 VHMHLKEHQETI--DKLRGIVSEKTNEISNMQKD------LEHSNDALKAQDLKIQEELR 1777

Query: 938  TSSSKRKEEFADMSKVHSVG-------SNGLLDFDSEYQELWDWLIDMESLVMDSHDLMM 990
             +    KE+   + K+  +        SN   D ++   +L +    ++ L  + H L+ 
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQE---KIQELKANEHQLIT 1834

Query: 991  SEEQQQHLYKRYS-VEMSIRHLKKTEL-LSKVEALKKGGVLLPNDLLEKVDS-------- 1040
             ++      K+ S +E   + +K   L LSK+E          ++ LE++ S        
Sbjct: 1835 LKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNL 1894

Query: 1041 --INEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTE 1098
              + E  +L    L E +Q+T A       RDL   +     R L    KE    LR+  
Sbjct: 1895 RRVEETLKLERDQLKESLQETKA-------RDLEIQQELKTARMLSKEHKETVDKLREK- 1946

Query: 1099 LFIFNSCLRQEKEGTMNTEKQLQYFK-SLCREIKQRRRGVASILRLCQHLLDDRETCNLN 1157
                   + ++     + +K L   K  L ++I++ ++    +LR+ +         ++N
Sbjct: 1947 -------ISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKE---------DVN 1990

Query: 1158 ADHQPMQLIIVNLERRWEA--IVMQAVQWQT-RLQKKMGKESETLNVI 1202
              H+ +   +  L++++EA  + MQ+V+    +L KK+ +  E + ++
Sbjct: 1991 MSHKKIN-EMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV 2037



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 55/263 (20%), Positives = 110/263 (41%), Gaps = 39/263 (14%)

Query: 809  KAEMDDLKLYLE-THLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQ 867
            + E+ DLK  LE   L  +        L + +EE+   LL+ + + K  ++++ RM+ + 
Sbjct: 349  RKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEK--DLLQKVQNEK--IENLTRMLVTS 404

Query: 868  -----WKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQR 922
                  +EL+ + KR+ +W L  ++ +K    A   ++     T + K  + L       
Sbjct: 405  SSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINL------- 457

Query: 923  DAVEQMSLKLYSEQYTSSSKRKEEFAD-MSKVHSVGSNGLLDFDSEYQELWDWLIDMESL 981
                   L+   E   S S       D +S++    +  LL+ ++   EL     D ++L
Sbjct: 458  -------LREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNL 510

Query: 982  VMDSHDLMMSEEQQQHLYKR-------YSVEMSIRHLKKTELLSKVEALKK-------GG 1027
            V+D   L   +E+ +   K         ++E   +  ++ +L+ ++  LK          
Sbjct: 511  VLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYN 570

Query: 1028 VLLPNDLLEKVDSINEKWELLGK 1050
              L N+L  KV+ + EK + + K
Sbjct: 571  QDLENELSSKVELLREKEDQIKK 593


>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
          Length = 1173

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 127/630 (20%), Positives = 259/630 (41%), Gaps = 87/630 (13%)

Query: 646  KLENLTKLLPQKPRGETI---QNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSS 702
            +++N  KL+ ++  GE     Q ++D+   E     +I     ++ K T LGR+      
Sbjct: 253  QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQID---EIRDKKTGLGRII----- 304

Query: 703  DIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQ 762
                 L   I S   +++ + +     L G      E  +    +E+ E   A K++ ++
Sbjct: 305  ----ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAER-ELSKAEKNSNVE 359

Query: 763  KLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETT---ENWTPPKAEMDDLKLYL 819
             L  ++    N +A    ++  + KLD+ ++ LN    T    E  T  KA+ D+    +
Sbjct: 360  TLKMEVISLQNEKA---DLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKI 416

Query: 820  ETHLSFKL-NVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWK-------EL 871
            ++  S +L ++  +   K+ +E+  H   + I   +  L  + + +AS  +       EL
Sbjct: 417  KSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNEL 476

Query: 872  QRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLK 931
            +R+ ++  S+  +  D   ++   +D+    EE   S K    L    A      Q   +
Sbjct: 477  KRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATA---VYSQFITQ 533

Query: 932  LYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMS 991
            L  E  +     +  F   +++  V S    D  S+ +   D L   ES      +L   
Sbjct: 534  LTDENQSCCPVCQRVFQTEAELQEVIS----DLQSKLRLAPDKLKSTES------ELKKK 583

Query: 992  EEQQQHLYKRYSVEMSIRHLKKTE---LLSKVEALKKGGVLLPNDLLEKVDSINEKWELL 1048
            E+++  +     +  SI  LK+ E   L +K++ + +    L ND       I E+  LL
Sbjct: 584  EKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKND-------IEEQETLL 636

Query: 1049 GKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQ 1108
            G  + E+ +      +  +  +    E   + R++  +  +L+G   D  +   N   +Q
Sbjct: 637  GTIMPEE-ESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQ-EKQ 694

Query: 1109 EKEGTMNT---------------EKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRET 1153
            EK+  ++T               ++Q+Q+ KS   E+K  +  +++ L+  Q L  + +T
Sbjct: 695  EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQL--EEQT 752

Query: 1154 CNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMS 1213
              L+ + Q       +L R  +    Q    +T L+K   ++ E +N  +      N ++
Sbjct: 753  VELSTEVQ-------SLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTS----NKIA 801

Query: 1214 EDALEWDEMDISNKLISLNEESNDLDQELQ 1243
            +D L     DI  K+ +++    D++  +Q
Sbjct: 802  QDKLN----DIKEKVKNIHGYMKDIENYIQ 827


>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
          Length = 1312

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 127/630 (20%), Positives = 259/630 (41%), Gaps = 87/630 (13%)

Query: 646  KLENLTKLLPQKPRGETI---QNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSS 702
            +++N  KL+ ++  GE     Q ++D+   E     +I     ++ K T LGR+      
Sbjct: 392  QIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQID---EIRDKKTGLGRII----- 443

Query: 703  DIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQ 762
                 L   I S   +++ + +     L G      E  +    +E+ E   A K++ ++
Sbjct: 444  ----ELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAER-ELSKAEKNSNVE 498

Query: 763  KLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETT---ENWTPPKAEMDDLKLYL 819
             L  ++    N +A    ++  + KLD+ ++ LN    T    E  T  KA+ D+    +
Sbjct: 499  TLKMEVISLQNEKA---DLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKI 555

Query: 820  ETHLSFKL-NVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWK-------EL 871
            ++  S +L ++  +   K+ +E+  H   + I   +  L  + + +AS  +       EL
Sbjct: 556  KSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNEL 615

Query: 872  QRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLK 931
            +R+ ++  S+  +  D   ++   +D+    EE   S K    L    A      Q   +
Sbjct: 616  KRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATA---VYSQFITQ 672

Query: 932  LYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMS 991
            L  E  +     +  F   +++  V S    D  S+ +   D L   ES      +L   
Sbjct: 673  LTDENQSCCPVCQRVFQTEAELQEVIS----DLQSKLRLAPDKLKSTES------ELKKK 722

Query: 992  EEQQQHLYKRYSVEMSIRHLKKTE---LLSKVEALKKGGVLLPNDLLEKVDSINEKWELL 1048
            E+++  +     +  SI  LK+ E   L +K++ + +    L ND       I E+  LL
Sbjct: 723  EKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKND-------IEEQETLL 775

Query: 1049 GKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQ 1108
            G  + E+ +      +  +  +    E   + R++  +  +L+G   D  +   N   +Q
Sbjct: 776  GTIMPEE-ESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQ-EKQ 833

Query: 1109 EKEGTMNT---------------EKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRET 1153
            EK+  ++T               ++Q+Q+ KS   E+K  +  +++ L+  Q L  + +T
Sbjct: 834  EKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQL--EEQT 891

Query: 1154 CNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMS 1213
              L+ + Q       +L R  +    Q    +T L+K   ++ E +N  +      N ++
Sbjct: 892  VELSTEVQ-------SLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTS----NKIA 940

Query: 1214 EDALEWDEMDISNKLISLNEESNDLDQELQ 1243
            +D L     DI  K+ +++    D++  +Q
Sbjct: 941  QDKLN----DIKEKVKNIHGYMKDIENYIQ 966


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 100/487 (20%), Positives = 206/487 (42%), Gaps = 87/487 (17%)

Query: 747  SEKNESHSA-----------TKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQW- 794
            +E+NE H              K A ++KL   +  Q    A+ ++  G   +    +Q  
Sbjct: 1557 AERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGS 1616

Query: 795  -------LNEAMETTENWTPPKAE-MDDLKLYLETHLSFK---LNVDSH------CALKE 837
                   L EA+   E     K   + ++K  LE  LSF+   LNV           +K+
Sbjct: 1617 MVQAKADLQEALRLGETEVTEKCNHIREVKSLLE-ELSFQKGELNVQISERKTQLTLIKQ 1675

Query: 838  AVEEEGHQL---LELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEIL 894
             +E+E   L   L  ++ HK  LK++L M+  +  ELQ  +K QH   +  L+  +  +L
Sbjct: 1676 EIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQ-GLKLQHDQRVSELEKTQVAVL 1734

Query: 895  ATDVSVED-EEGTGSPKAEV--QLCYLEAQRDAVEQMSLKLYSEQ--YTSSSKRKEEFAD 949
               + +E+ ++ +   K E+  Q   LE  +  +E+M+ +  + Q      SK KE+   
Sbjct: 1735 EEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDL-- 1792

Query: 950  MSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIR 1009
                             E  ++W+  +     V+ + +   S+ +Q +L K   +E+++R
Sbjct: 1793 ----------------QEKCDIWEKKLAQTKRVLAAAE-ENSKMEQSNLEK---LELNVR 1832

Query: 1010 HLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPR 1069
             L++     +++ L +  + L ND+      + EK E +  +L E++ + +  H   + +
Sbjct: 1833 KLQQ-----ELDQLNRDKLSLHNDISAMQQQLQEKREAV-NSLQEELAN-VQDHLNLAKQ 1885

Query: 1070 DLL-SPESGSLVRQLEVRI-KELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLC 1127
            DLL + +   ++   + R+ K++  W        F  C ++E       E + Q  + L 
Sbjct: 1886 DLLHTTKHQDVLLSEQTRLQKDISEWANR-----FEDCQKEE-------ETKQQQLQVLQ 1933

Query: 1128 REIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTR 1187
             EI++ +  +     + Q L  +RE     ++   ++   V L+ +   +  +    +++
Sbjct: 1934 NEIEENKLKLVQQEMMFQRLQKERE-----SEESKLETSKVTLKEQQHQLEKELTDQKSK 1988

Query: 1188 LQKKMGK 1194
            L + + K
Sbjct: 1989 LDQVLSK 1995



 Score = 39.3 bits (90), Expect = 0.046
 Identities = 89/435 (20%), Positives = 170/435 (39%), Gaps = 66/435 (15%)

Query: 716  PLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYE 775
            PL   L D+E  +  A  +      SE     EK E      +   ++L + IQ +   E
Sbjct: 434  PLDTQLEDKEKKISAAQTRL-----SELHDEIEKAEQQILRATEEFKQLEEAIQLKKISE 488

Query: 776  A----IWEKIEG---FVNKLDEFIQWLNEAMETTENWTPPKA-EMDDLKLYLETHLSFKL 827
            A    +++++ G    VNKL +    L   ME  +     K  E+ DL++ +++ L  K 
Sbjct: 489  AGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS-LDSKD 547

Query: 828  NVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALD 887
               SH                 + + K+G +  L ++  Q+++L+ ++    S I +  +
Sbjct: 548  PKHSH-----------------MKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETE 590

Query: 888  TIK--------AEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTS 939
             IK         +I A +   +D EG  S   E  L  ++ Q    +    KL  E+ T 
Sbjct: 591  EIKDLEEQLTEGQIAANEALKKDLEGVISGLQEY-LGTIKGQATQAQNECRKLRDEKETL 649

Query: 940  SSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLY 999
              +  E   +  ++  V     +D ++  +EL     ++ES + + H++  S +Q Q   
Sbjct: 650  LQRLTEVEQERDQLEIVA----MDAENMRKEL----AELESALQEQHEVNASLQQTQGDL 701

Query: 1000 KRYSVEMSIR-HLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQD 1058
              Y  E+  R +L+  E                N L E+++ +    +L    L  +++ 
Sbjct: 702  SAYEAELEARLNLRDAE---------------ANQLKEELEKVTRLTQLEQSALQAELEK 746

Query: 1059 TMAGHSGSSPRDLLSPESGSLVRQLEVRIKELK--GWLRDTELFIFNSCLRQEKEGTMNT 1116
                   +  +   S E      +L  ++K L+    L   +L  F + L    +G +  
Sbjct: 747  ERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRP 806

Query: 1117 EKQLQYFKSLCREIK 1131
            E+       L R++K
Sbjct: 807  EEVAARVDELRRKLK 821


>gi|110611228 utrophin [Homo sapiens]
          Length = 3433

 Score = 46.6 bits (109), Expect = 3e-04
 Identities = 69/382 (18%), Positives = 161/382 (42%), Gaps = 57/382 (14%)

Query: 734  KKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQ 793
            KK  +E++    S+   E H + ++     + +     D+Y+            L+E + 
Sbjct: 274  KKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIA----------LEEVLT 323

Query: 794  WLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLL---ELI 850
            WL  A +T +       +++++K    TH +F + + +H +   +V + G+QL+    L 
Sbjct: 324  WLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLS 383

Query: 851  ASHKAGLKDMLRMIASQWKELQRQIKRQHSW---ILRALDTIKAEILATDVSVEDEEGTG 907
               +  +++ + ++ ++W+ L+ +   + S    +L  L   + + L+  +++ +E    
Sbjct: 384  DEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEER--- 440

Query: 908  SPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSV-------GSNG 960
                +++ C L+   D V+ +   L   +   S    E+    S  H V       G + 
Sbjct: 441  --IQKMETCPLD---DDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESA 495

Query: 961  LLDFDSEYQELWD-------WLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKK 1013
                + + Q+L +       W  +  + + + + L     ++Q L K +  E       K
Sbjct: 496  TAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTE-------K 548

Query: 1014 TELLSKVEALK-----------KGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAG 1062
             E L+KV+              +   +L  D+  K  ++++  E +G+ +G+ + ++ A 
Sbjct: 549  EEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSE-IGQDVGQLLDNSKAS 607

Query: 1063 HSGSSPRDLLSPESGSLVRQLE 1084
               +S  + L+    SLV++LE
Sbjct: 608  KKINSDSEELTQRWDSLVQRLE 629



 Score = 33.1 bits (74), Expect = 3.3
 Identities = 54/292 (18%), Positives = 122/292 (41%), Gaps = 39/292 (13%)

Query: 973  DWLIDMESLVMDSHDLMMS---EEQQQHLYKRYSV-EMSIRHLK-KTELLSKVEAL---K 1024
            D+L+++  +++   D+ +S    E    +Y+ +S  E S++++K + + L +  A+   K
Sbjct: 1871 DYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEK 1930

Query: 1025 KGGVLLPND------LLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGS 1078
            +  V+L         + + +  +N KW+ + +   ++         G   R +       
Sbjct: 1931 QPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDR--------KGCFDRAMEE----- 1977

Query: 1079 LVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVA 1138
              RQ    + +L  W+ + E  + ++C      G+++ EK   + + L   I   +   A
Sbjct: 1978 -WRQFHCDLNDLTQWITEAEELLVDTCA---PGGSLDLEKARIHQQELEVGISSHQPSFA 2033

Query: 1139 SILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESET 1198
            ++ R    ++         AD   ++  +  L +RW+AIV +    Q RL+ +  +  + 
Sbjct: 2034 ALNRTGDGIVQKLS----QADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKY 2089

Query: 1199 LNVIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLK 1250
             + +D  +  L        +    ++   L    +E  DL QE++     LK
Sbjct: 2090 RHQLDEIICWLTKAEHAMQKRSTTELGENL----QELRDLTQEMEVHAEKLK 2137



 Score = 31.6 bits (70), Expect = 9.5
 Identities = 64/280 (22%), Positives = 105/280 (37%), Gaps = 72/280 (25%)

Query: 1032 NDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDL---LSPESGSLVRQLE---- 1084
            ND+ + +D   +K   + K LG   + TM  H           L  +S S+   LE    
Sbjct: 2503 NDIFKSIDGNRQK---MVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAE 2559

Query: 1085 ------VRIKELKGWL--RDTELFIFNSCLRQEKEGTMNTEKQLQY--FKSLCREIKQRR 1134
                  + ++EL  WL  +D EL       +Q   G      QLQY   K+L RE+K++ 
Sbjct: 2560 KWNRLLMSLEELIKWLNMKDEEL------KKQMPIGGDVPALQLQYDHCKALRRELKEKE 2613

Query: 1135 RGVASILRLCQHLLDDRETCNLNADHQP----------------------MQLIIVNLER 1172
              V + +   +  L D+    + A  +P                      M+     ++ 
Sbjct: 2614 YSVLNAVDQARVFLADQP---IEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKE 2670

Query: 1173 RWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDL-------NGMSE--DALEWDEMD 1223
            +WE++      WQ ++ K + K  +    +D    D+       NG     D L     D
Sbjct: 2671 KWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQD 2730

Query: 1224 ISNKLISLNEE----------SNDLDQELQP--VIPSLKL 1251
               K+++  EE           NDL  +L P  + PSLK+
Sbjct: 2731 HIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKM 2770


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
            sapiens]
          Length = 2564

 Score = 45.8 bits (107), Expect = 5e-04
 Identities = 86/432 (19%), Positives = 181/432 (41%), Gaps = 57/432 (13%)

Query: 748  EKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTP 807
            EKN+ +       +QKL   ++           ++ F+    E   W++E M    + T 
Sbjct: 1285 EKNQENQLRAQQWMQKLHDQLE-----------LQHFLRDCHELDGWIHEKMLMARDGT- 1332

Query: 808  PKAEMDDLKLYLE--THLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIA 865
                 D+ KL+     H +F   +  +    E +E EG QL++      A ++  L  I 
Sbjct: 1333 ---REDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIR 1389

Query: 866  SQWKELQ-------RQI--KRQHSWILRALDTIKAEILATDVSVED-EEGTGSPKAEVQL 915
              W EL+       RQ+    +   ++++   +  ++L  +  ++D + G        QL
Sbjct: 1390 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 1449

Query: 916  CYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADM---SKVHSVGSNGLLDFDSEYQELW 972
              L++    VE+   ++   Q  +++   E  +      + ++VG   L+      QE  
Sbjct: 1450 KKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGER-LVRLLEPLQERR 1508

Query: 973  DWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSI----------RHLKKTELLSKVEA 1022
              L+  + L   +HDL   +++   + +R  + M            +H+KK + L + E 
Sbjct: 1509 RLLLASKELHQVAHDL---DDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRR-EI 1564

Query: 1023 LKKGGVLLPNDLLEKVDSI----NEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGS 1078
               G  L   ++LE+  ++    + + E + + L E++Q   AG   ++ R     ++  
Sbjct: 1565 QAHGPRL--EEVLERAGALASLRSPEAEAVRRGL-EQLQSAWAGLREAAERRQQVLDAAF 1621

Query: 1079 LVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMN-TEKQLQYFKSLCREIKQRRRGV 1137
             V Q    + E++ WL + EL + +    ++++ T+   +K LQ    L + ++     +
Sbjct: 1622 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQ----LEQGVENYEESI 1677

Query: 1138 ASILRLCQHLLD 1149
            A + R C+ LL+
Sbjct: 1678 AQLSRQCRALLE 1689


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 90/463 (19%), Positives = 186/463 (40%), Gaps = 56/463 (12%)

Query: 719  DILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIW 778
            D + D+ +   L   +KY ++K E      +N+S S   S L    +   +H+    A+ 
Sbjct: 745  DAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALK 804

Query: 779  EKIEGFVNKLDEFIQWLNEAME-----TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHC 833
              I     +L E  +   E  E     T+EN T  K  M +  + ++TH   K+ ++   
Sbjct: 805  SNIVELKKQLSELKKKCGEDQEKIHALTSEN-TNLKKMMSNQYVPVKTHEEVKMTLNDTL 863

Query: 834  ALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQH-------------S 880
            A       +  +  E I      +KD   ++    +  Q QIK ++             S
Sbjct: 864  AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 923

Query: 881  WILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQ-----MSLKLYSE 935
              +R +    AEILA     ++E  T   + + Q   L+  ++ ++      +S +    
Sbjct: 924  QSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER 983

Query: 936  QYTSSSKR-KEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQ 994
            ++ ++ K  K++ ++ ++ +SV    +     E  +L   +  ++  + D   L+    +
Sbjct: 984  KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1043

Query: 995  QQHLYKRYSVEMS------------IRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSIN 1042
             +    R + E++            ++++K  E L +  A +   +L   +LL+K     
Sbjct: 1044 MERALSRKTDELNKQLKDLSQKYTEVKNVK--EKLVEENAKQTSEILAVQNLLQKQHVPL 1101

Query: 1043 EKWELLGKTLGEKIQD------------TMAGHSGSSPRDLLSPESGSLVRQLE-VRIKE 1089
            E+ E L K+L   I++                 + +    LL  +  S V   E ++IKE
Sbjct: 1102 EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE 1161

Query: 1090 LKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQ 1132
                  + E+ I  + LR+++E + N  +++   +S  +  KQ
Sbjct: 1162 ----AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1200


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 90/463 (19%), Positives = 186/463 (40%), Gaps = 56/463 (12%)

Query: 719  DILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIW 778
            D + D+ +   L   +KY ++K E      +N+S S   S L    +   +H+    A+ 
Sbjct: 758  DAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALK 817

Query: 779  EKIEGFVNKLDEFIQWLNEAME-----TTENWTPPKAEMDDLKLYLETHLSFKLNVDSHC 833
              I     +L E  +   E  E     T+EN T  K  M +  + ++TH   K+ ++   
Sbjct: 818  SNIVELKKQLSELKKKCGEDQEKIHALTSEN-TNLKKMMSNQYVPVKTHEEVKMTLNDTL 876

Query: 834  ALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQH-------------S 880
            A       +  +  E I      +KD   ++    +  Q QIK ++             S
Sbjct: 877  AKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLS 936

Query: 881  WILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQ-----MSLKLYSE 935
              +R +    AEILA     ++E  T   + + Q   L+  ++ ++      +S +    
Sbjct: 937  QSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECER 996

Query: 936  QYTSSSKR-KEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQ 994
            ++ ++ K  K++ ++ ++ +SV    +     E  +L   +  ++  + D   L+    +
Sbjct: 997  KFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSHE 1056

Query: 995  QQHLYKRYSVEMS------------IRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSIN 1042
             +    R + E++            ++++K  E L +  A +   +L   +LL+K     
Sbjct: 1057 MERALSRKTDELNKQLKDLSQKYTEVKNVK--EKLVEENAKQTSEILAVQNLLQKQHVPL 1114

Query: 1043 EKWELLGKTLGEKIQD------------TMAGHSGSSPRDLLSPESGSLVRQLE-VRIKE 1089
            E+ E L K+L   I++                 + +    LL  +  S V   E ++IKE
Sbjct: 1115 EQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPLAEHLQIKE 1174

Query: 1090 LKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQ 1132
                  + E+ I  + LR+++E + N  +++   +S  +  KQ
Sbjct: 1175 ----AFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQ 1213


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.125    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,684,699
Number of Sequences: 37866
Number of extensions: 4213193
Number of successful extensions: 15049
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 26
Number of HSP's successfully gapped in prelim test: 320
Number of HSP's that attempted gapping in prelim test: 13383
Number of HSP's gapped (non-prelim): 1876
length of query: 2319
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2201
effective length of database: 13,779,330
effective search space: 30328305330
effective search space used: 30328305330
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.