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Search of human proteins with 21493022
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
(1782 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 3459 0.0
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 3254 0.0
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 122 2e-27
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 108 4e-23
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 101 6e-21
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 101 7e-21
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 98 6e-20
gi|110349719 titin isoform N2-A [Homo sapiens] 94 2e-18
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 92 6e-18
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 88 8e-17
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 87 1e-16
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 87 1e-16
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 87 2e-16
gi|238624188 diffuse panbronchiolitis critical region 1 protein ... 82 4e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 82 5e-15
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit... 81 1e-14
gi|87299628 biorientation of chromosomes in cell division 1-like... 80 1e-14
gi|148806928 hypothetical protein LOC57482 [Homo sapiens] 79 5e-14
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 77 1e-13
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 77 1e-13
gi|38176300 nestin [Homo sapiens] 75 6e-13
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 74 1e-12
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 74 2e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 74 2e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 74 2e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 74 2e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 74 2e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 74 2e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 74 2e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 74 2e-12
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 3459 bits (8970), Expect = 0.0
Identities = 1782/1782 (100%), Positives = 1782/1782 (100%)
Query: 1 MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNG 60
MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNG
Sbjct: 1 MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNG 60
Query: 61 QLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDS 120
QLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDS
Sbjct: 61 QLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDS 120
Query: 121 DKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVG 180
DKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVG
Sbjct: 121 DKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVG 180
Query: 181 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPE 240
FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPE
Sbjct: 181 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPE 240
Query: 241 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 300
ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF
Sbjct: 241 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 300
Query: 301 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 360
TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE
Sbjct: 301 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 360
Query: 361 PAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVH 420
PAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVH
Sbjct: 361 PAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVH 420
Query: 421 VSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGA 480
VSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGA
Sbjct: 421 VSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGA 480
Query: 481 DLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG 540
DLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG
Sbjct: 481 DLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG 540
Query: 541 DEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDG 600
DEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDG
Sbjct: 541 DEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDG 600
Query: 601 EKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGS 660
EKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGS
Sbjct: 601 EKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGS 660
Query: 661 VEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKD 720
VEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKD
Sbjct: 661 VEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKD 720
Query: 721 KETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKS 780
KETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKS
Sbjct: 721 KETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKS 780
Query: 781 EDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDD 840
EDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDD
Sbjct: 781 EDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDD 840
Query: 841 SDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGT 900
SDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGT
Sbjct: 841 SDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGT 900
Query: 901 RAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREA 960
RAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREA
Sbjct: 901 RAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREA 960
Query: 961 RGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEAT 1020
RGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEAT
Sbjct: 961 RGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEAT 1020
Query: 1021 PVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQ 1080
PVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQ
Sbjct: 1021 PVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQ 1080
Query: 1081 AEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQ 1140
AEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQ
Sbjct: 1081 AEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQ 1140
Query: 1141 AETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEV 1200
AETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEV
Sbjct: 1141 AETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEV 1200
Query: 1201 ASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
ASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK
Sbjct: 1201 ASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL
Sbjct: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1380
ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV
Sbjct: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1380
Query: 1381 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILET 1440
PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILET
Sbjct: 1381 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILET 1440
Query: 1441 GETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDL 1500
GETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDL
Sbjct: 1441 GETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDL 1500
Query: 1501 EGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQ 1560
EGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQ
Sbjct: 1501 EGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQ 1560
Query: 1561 FVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESES 1620
FVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESES
Sbjct: 1561 FVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESES 1620
Query: 1621 TAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDG 1680
TAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDG
Sbjct: 1621 TAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDG 1680
Query: 1681 HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKED 1740
HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKED
Sbjct: 1681 HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKED 1740
Query: 1741 AQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1782
AQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES
Sbjct: 1741 AQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1782
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 3254 bits (8437), Expect = 0.0
Identities = 1677/1680 (99%), Positives = 1677/1680 (99%)
Query: 103 IVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 162
I VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP
Sbjct: 5 ITITVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 64
Query: 163 TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGA 222
TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGA
Sbjct: 65 TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGA 124
Query: 223 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE 282
GEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE
Sbjct: 125 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAE 184
Query: 283 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK 342
SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK
Sbjct: 185 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK 244
Query: 343 AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE 402
AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE
Sbjct: 245 AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATE 304
Query: 403 VFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKE 462
VFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKE
Sbjct: 305 VFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKE 364
Query: 463 LVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTS 522
LVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTS
Sbjct: 365 LVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTS 424
Query: 523 TGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKG 582
TGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKG
Sbjct: 425 TGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKG 484
Query: 583 LAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT 642
LAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT
Sbjct: 485 LAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT 544
Query: 643 LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG 702
LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG
Sbjct: 545 LSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG 604
Query: 703 GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF 762
GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF
Sbjct: 605 GPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESF 664
Query: 763 KRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 822
KRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK
Sbjct: 665 KRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 724
Query: 823 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 882
QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK
Sbjct: 725 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 784
Query: 883 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 942
ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI
Sbjct: 785 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVI 844
Query: 943 AEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEM 1002
AEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEM
Sbjct: 845 AEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEM 904
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGP 1062
VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGP
Sbjct: 905 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGP 964
Query: 1063 EDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEK 1122
EDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEK
Sbjct: 965 EDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEK 1024
Query: 1123 APQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA 1182
APQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA
Sbjct: 1025 APQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA 1084
Query: 1183 PGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDT 1242
PGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDT
Sbjct: 1085 PGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDT 1144
Query: 1243 LEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEV 1302
LEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEV
Sbjct: 1145 LEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEV 1204
Query: 1303 ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET
Sbjct: 1205 ALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1264
Query: 1363 AVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLT 1422
AVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLT
Sbjct: 1265 AVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLT 1324
Query: 1423 AAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAK 1482
AAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAK
Sbjct: 1325 AAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAK 1384
Query: 1483 STPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILEL 1542
STPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILEL
Sbjct: 1385 STPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILEL 1444
Query: 1543 ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQ 1602
ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQ
Sbjct: 1445 ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQ 1504
Query: 1603 ASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP 1662
ASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP
Sbjct: 1505 ASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP 1564
Query: 1663 SEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGG 1722
SEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGG
Sbjct: 1565 SEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGG 1624
Query: 1723 LTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1782
LTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES
Sbjct: 1625 LTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1684
Score = 53.5 bits (127), Expect = 2e-06
Identities = 142/707 (20%), Positives = 245/707 (34%), Gaps = 115/707 (16%)
Query: 3 AGSSTEQRSPEQ--PPEGSSTPAEPEPSGGGPSAE-AAPDTTADPAIAASDPATKLLQKN 59
AG +++ EQ PP+ TP + E G P A+ AP TT
Sbjct: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTT------------------ 1088
Query: 60 GQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRD 119
Q I + E++E++ Q G + +E + V Q ++++ SK +
Sbjct: 1089 -QKDEIVEIHEENEVA-----SGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKME 1142
Query: 120 SDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFV 179
E K V ++ I S +E Q + + D+ F F
Sbjct: 1143 DTLEHTDKEVSVETVS-------------ILSKTEGTQEADQYADEKTKDVPF-----FE 1184
Query: 180 GFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKP 239
G + ++ T + V + +K GEG A KD +L E S P E+
Sbjct: 1185 GLEGSIDTGITVSREKVTEVALK---GEGTEEAECKKDDAL---ELQSHAKSPPSPVERE 1238
Query: 240 EET-LKREQSHAEISPPAESGQAVEECKEEGEEKQEK-------------EPSKSAESPT 285
++RE++ AE + E E EE ++ + S E
Sbjct: 1239 MVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1298
Query: 286 SPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEV 345
P + + K Q + SF E E + E +T E A +
Sbjct: 1299 PPCLGQEEAVCTKIQVQS-----SEASFTLTAAAEEEKVLGETANILETGETLEPAGAHL 1353
Query: 346 ASEKLTASEQ----AHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLAT 401
E+ ++ + AHP E A + + P + +G S + T
Sbjct: 1354 VLEEKSSEKNEDFAAHPGEDAVPT-----GPDCQAKSTPVIVSATTKKGLSSDLEGEKTT 1408
Query: 402 EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVE-ETAGSVPAEELVEMDAEPQEAEPA 460
+ + EV ++ EV VS E E + +E ET S + +++ +
Sbjct: 1409 SLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVD------- 1461
Query: 461 KELVKLKETC---VSGEDPTQGADLSPD--------EKVLSKPPEGVVSEVEMLSSQERM 509
+ V+ +ET ++ E TQ + D EK +P E + S++E
Sbjct: 1462 -QFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEES 1520
Query: 510 KVQGSPLKKLFTSTGLKKLSGKKQKGKRGGG--DEESGEHTQVPADSPDSQEEQKGESSA 567
+ S + + S K + G +++ E +P S+EE G +
Sbjct: 1521 ESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLP-----SEEEGGGAGTK 1575
Query: 568 SSPEEPEEITC---LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVR 624
S PE+ +EK L E ++D + ++ D E + + + +
Sbjct: 1576 SVPEDDGHALLAERIEKSLVEPKEDEKGDD--VDDPENQNSALADTDASGGLTKESPDTN 1633
Query: 625 RPSESDKED----ELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 667
P + +KED EL + K + S T +E K E K E
Sbjct: 1634 GPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1680
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 122 bits (307), Expect = 2e-27
Identities = 255/1073 (23%), Positives = 405/1073 (37%), Gaps = 171/1073 (15%)
Query: 223 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAES-GQA-----VEECKEEGEEKQEKE 276
GE +E+ + T K EE L+ E E + E GQ +EE +E G E ++E
Sbjct: 1312 GEGLQEEAVQLEET-KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEE 1370
Query: 277 PSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVD 336
+ E P G ++ + G ++ S + E + + K QE + V
Sbjct: 1371 GVQLEEVKEGPEGGLQGEALEEGLKE--EGLPEEGSVHGQELSEASSPDGKGSQEDDPVQ 1428
Query: 337 TEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKP 396
EE G+A ++E A P EP E SA SE Q P EKP
Sbjct: 1429 EEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSA--------SERQSGSQLEPGLEKP 1480
Query: 397 APLATEVFDEKIEVHQEEVVAE---------------VHVSTVEERTEE--------QKT 433
P AT + E + + AE + VS + ++TE+
Sbjct: 1481 -PGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
Query: 434 EVEETAGSVPAEELVEMDAEPQE--AEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSK 491
E+ G + L +M AE Q+ A+ ++ K + + G VL
Sbjct: 1540 ELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGR---------AGRMVLEP 1590
Query: 492 PPEGVVSEVEMLSSQERMKVQGSPLKKLFT--STGLKKLSGKKQK--------GKRGGGD 541
P E + E+ + + Q R +++G F+ + GL LS + G + G +
Sbjct: 1591 PREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEE 1650
Query: 542 EESGEHTQVPA-----DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGA 596
E E A SP S + G + E + L++ E DGEA E A
Sbjct: 1651 AEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGE-HTDGEAAEVA 1709
Query: 597 T----SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASE 652
+D R ++ V + + L++ K L E A
Sbjct: 1710 PGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDA-- 1767
Query: 653 MQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQ 712
M +E +G +TS E +G +++ S E GG
Sbjct: 1768 MAQEREGKTHNS---------ETSAGSE----LGEAEQEGEGISERGETGG--------- 1805
Query: 713 KADEAGKDKETGTDGILAGSQEHDPGQ-----GSSSPEQAG-SPTEGEGVSTWESFKRLV 766
G E G A + DPGQ G +PE G + E EGV E+
Sbjct: 1806 ----QGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEA----E 1857
Query: 767 TPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGK--EESWVSIKKFIPGRRKKRPDGKQE 824
++++ + + +SED A + P++E + E W + +P+ +
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEW-----------EVQPESEGA 1906
Query: 825 QAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL 884
+AP + A + V A+ E D E E EAQ+A+++A++ E + E S+ +
Sbjct: 1907 EAPEAE---KEAQPETESVEALETEGE-DEPESEGAEAQEAEEAAQEAEGQTQPE-SEVI 1961
Query: 885 SESQVHMMAAAVADGTRAATI-IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIA 943
+ A ++ A + +E + + +E +E EAE E+ E E A
Sbjct: 1962 ESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG-----EMQEAEEEA 2016
Query: 944 EEEPPTV-TEPLPENREAR---GDTVVSEAELTPEAVTAAETAGPLGAEEGTEA-SAAEE 998
+ E V +P E EA+ G+T +E + PE+ +G EA A EE
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES-------------DGVEAPEAEEE 2063
Query: 999 TTEMVSAVSQLTDSPDTTEEATPVQEVEG-GVPDIEEQERRTQEVLQAVAEKVKEESQLP 1057
E V + E QE EG P+ E E E AE + E +
Sbjct: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI-EAPETE 2122
Query: 1058 GTGGPED--VLQPVQRAEAERPEEQAEASGLKKETDVVLK-VDAQEAKTEPFTQGKVVGQ 1114
G PE + P EA+ E EA + E + ++AQEA+ E Q ++ G
Sbjct: 2123 GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEE--AQPELEGV 2180
Query: 1115 TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGS 1174
PE+ +A +E IE+ E Q E L GV++ E E P+ VETP E +G
Sbjct: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPE-LEGVEAPEAEEEAQPEPEGVETP---EAEGE 2236
Query: 1175 TPVADFDAPGTTQKDEIVEIHEENEVASGT-QSGGTEAEAVPAQKERPPAPSS 1226
A ++ G TQ ++ +V+ G QS + P ++RP P S
Sbjct: 2237 ---AQPESEGETQGEK----KGSPQVSLGDGQSEEASESSSPVPEDRPTPPPS 2282
Score = 92.8 bits (229), Expect = 3e-18
Identities = 239/1137 (21%), Positives = 407/1137 (35%), Gaps = 144/1137 (12%)
Query: 310 KTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR 369
KTS ++P E+ + Q+ T + +A + +E+ ++ A S E +
Sbjct: 1233 KTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLE-Q 1291
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+ + E+ EE G++G E QEE V ++ + EE +
Sbjct: 1292 LAENTVQEEVQLEETKEGTEG------------------EGLQEEAV-QLEETKTEEGLQ 1332
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPA------KELVKLKETCVSGEDPTQGADLS 483
E+ ++EET E E +A+ +E E +E V+L+E E QG L
Sbjct: 1333 EEGVQLEETK-ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
Query: 484 PDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEE 543
K P EG V E LS +GS + S + G +E
Sbjct: 1392 EGLKEEGLPEEGSVHGQE-LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP 1450
Query: 544 SGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKK 603
+ + + P + E Q G E+P T + + + Q A E ++S
Sbjct: 1451 TEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSA 1510
Query: 604 REGVTP-WASFKKMVTPKKRVRRPSESDKE-------DELDKVKSATLSSTESTASEMQE 655
P W S T K + + + E + D + + A +Q+
Sbjct: 1511 ALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQD 1570
Query: 656 EMKGSVEEPKPE------EPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG 709
K +++ + EP R+ T L+ ++ RG + + +G
Sbjct: 1571 STKRELQKLQGRAGRMVLEPPREALTG----ELLLQTQQRRHRLRGLRNLSAFSERTLGL 1626
Query: 710 DHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES-FKRLVTP 768
G L+ + E +P ++ Q G EGE E+ ++ V+P
Sbjct: 1627 -----------------GPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSP 1669
Query: 769 RKK------SKSKLEEKSE-----DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKK 817
++ ++E + G + + PGK + + + + G
Sbjct: 1670 MSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGG 1729
Query: 818 RPDGKQEQAPVEDAGPTGANED--DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 875
G Q P D G G + D + +E DA+ +E+ E
Sbjct: 1730 LGPGLS-QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQER----------EGKTHN 1778
Query: 876 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEE 935
+ T EL E++ +G I ER + S E Q EA A +
Sbjct: 1779 SETSAGSELGEAEQE------GEG------ISERGETGGQGSGHEDNLQGEAAAGGDQDP 1826
Query: 936 VLEREVIAEEEPPTVTEPLPENR-----EARGDTVVSEAELTPEA--VTAAETAGPLGAE 988
E P E PE+ EA GD +E E PE+ V A E G A+
Sbjct: 1827 GQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE--AQ 1884
Query: 989 EGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAE 1048
+E E V S+ ++P+ +EA P E + E E ++ AE
Sbjct: 1885 PESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
Query: 1049 KVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQ 1108
+ +E++ G PE + Q AE E E + L+ E V+ QEA+
Sbjct: 1945 EAAQEAE--GQTQPESEVIESQEAEEEAQPESEDVEALEVE------VETQEAE------ 1990
Query: 1109 GKVVGQTTPESFE-KAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPT 1167
G+ PES + +AP+ ++ +E +++ + E Q + ++ +T
Sbjct: 1991 ----GEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEG 2046
Query: 1168 DS--ETDG-STPVAD---FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERP 1221
D+ E+DG P A+ +A G Q+ E E H E+E ++ E EA P + E
Sbjct: 2047 DAQPESDGVEAPEAEEEAQEAEGEVQEAE-GEAHPESEDVDAQEA---EGEAQP-ESEGV 2101
Query: 1222 PAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFF 1281
AP + ++ + E E + +E + + E + D + + P
Sbjct: 2102 EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPES 2161
Query: 1282 EGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV 1341
EG+E + E A + EG + E + +A E + A+ VE
Sbjct: 2162 EGIEAQ-EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE----APE 2216
Query: 1342 EREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPP 1398
E+ + EP V + E E E + + V + DG E +S SP P
Sbjct: 2217 AEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273
Score = 92.0 bits (227), Expect = 4e-18
Identities = 145/700 (20%), Positives = 259/700 (37%), Gaps = 100/700 (14%)
Query: 204 DEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVE 263
++GEG+ KDP LG E + E + T E + E AE + G+ +
Sbjct: 1744 EDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE-----QEGEGIS 1798
Query: 264 ECKEEGEEKQEKEPSKSAESPTS----PVTSETGSTFKKFFTQGWA-------------- 305
E E G + E + E+ P S+ + +G A
Sbjct: 1799 ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEG 1858
Query: 306 GWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE----------EDGKAEVASEKLTASEQ 355
++ +P+ ++VEA E + E +PE D E E AE + A +
Sbjct: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPE 1918
Query: 356 AHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEV 415
E E+ E +E + + +EE ++G ++ + + ++ +E+ + E+V
Sbjct: 1919 TESVEALETEGEDEPESEGAEAQ-EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV 1977
Query: 416 VA-EVHVSTV----EERTEEQKTEVEETAGSV-PAEELVEMDAEPQEAEPAKELVKLKET 469
A EV V T E + E + E E G + AEE + +++ EA+P E + +E
Sbjct: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQE- 2036
Query: 470 CVSGEDPTQGADLSPDEKVLSKP--------PEGVVSEVEMLSSQERMKVQGSPLKKLFT 521
V GE D P+ + P EG V E E + E V
Sbjct: 2037 -VEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQ------E 2089
Query: 522 STGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEK 581
+ G + + + G+ + E + P ++Q E +G E PE +
Sbjct: 2090 AEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEG------IEAPE-----AE 2138
Query: 582 GLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRP-SESDKEDELDKVKS 640
G A+ + +G + A + + + EG+ + ++ + V P +E + + E + +++
Sbjct: 2139 GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEA 2198
Query: 641 ATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDE 700
E Q E++G VE P+ EE + V E G ++ + + ++
Sbjct: 2199 ------PEAEGEAQPELEG-VEAPEAEEEAQPEPEGV--ETPEAEGEAQPESEGETQGEK 2249
Query: 701 EGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWE 760
+G P+ GD Q + + D P G +P Q G S
Sbjct: 2250 KGSPQVSLGDGQSEEASESSSPVPED-----RPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304
Query: 761 SFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPD 820
S+ ++ L + +G H+ ES S
Sbjct: 2305 SWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS-------------- 2350
Query: 821 GKQEQAPVEDAGP-TGANE--DDSDVPAVVPLSEYDAVER 857
+QE+AP+ P GA+E D + A+ L+ +AV R
Sbjct: 2351 -EQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGR 2389
Score = 86.3 bits (212), Expect = 2e-16
Identities = 250/1189 (21%), Positives = 440/1189 (37%), Gaps = 165/1189 (13%)
Query: 1 MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNG 60
+G+ + TE +P +S+ SG G S E++ D + L N
Sbjct: 1184 LGSHAMTENFTP------TSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQ 1237
Query: 61 QLSTINGVAEQDELSLQE-GDLNGQKGA-----LNGQGALNSQEEEEVIVTEVGQRDSED 114
+ D + + GDL Q+ LN + + E+E +RDSE+
Sbjct: 1238 R---------PDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEA------ERDSEE 1282
Query: 115 VSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKK 174
+ S+ E ++ V ++ EET E E E EE Q E++ + ++
Sbjct: 1283 -QRASSNLEQLAENTVQEEVQ---LEETKEGTE----GEGLQEEAVQLEETKTEEGLQEE 1334
Query: 175 VFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAG----DHKDPSLGAGEAASKES 230
+ K T + + E + QL +++ GEG G + K+ G + + E
Sbjct: 1335 GVQLEETKETEGEGQQE--EEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
Query: 231 EPKQSTEKPEETLKREQSHAEISPP-------------AESGQA---VEECKEEGEEKQE 274
K+ PEE Q +E S P E+G+A E C EG E+
Sbjct: 1393 GLKEEG-LPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPT 1451
Query: 275 KEPSKSAESPTSPVTSETGSTFKKFFTQ--GWAGWRKKTSFRKPKEDEVEASEKKKEQEP 332
+ PS +E+ S ++GS + + G ++ + +P + E S
Sbjct: 1452 EPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAA 1511
Query: 333 EKVD----------TEEDGKAEVAS--EKLTASEQAHPQEPAESAHEPRLSAEYEKVELP 380
D TE+ A +AS +L A + + ++++
Sbjct: 1512 LDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDS 1571
Query: 381 SEEQVSGSQGPSE----EKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERT----EEQK 432
++ ++ QG + E P T + + + + ++S ERT
Sbjct: 1572 TKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
Query: 433 TEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKP 492
T +E A S + +AE +E P + V+ K + +S + T GA P ++
Sbjct: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPK-ATMGATRGPIKEAFDLQ 1690
Query: 493 PEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGG-----------GD 541
++L + G + T S + +G GG +
Sbjct: 1691 --------QILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDE 1742
Query: 542 EESGEHTQ-VPADSPDSQEEQKGESSASSPE----EPEEITCLEKGLAEVQQDGEAEEGA 596
E GE +Q + D E +G++ A E E E G AE + +G +E G
Sbjct: 1743 GEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGE 1802
Query: 597 T-SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQE 655
T G + + A+ + P +SD + ++ ++ + ES E
Sbjct: 1803 TGGQGSGHEDNLQGEAA-------AGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVE-AP 1854
Query: 656 EMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRAR--RGSSSDEEGGPKAMGGDHQK 713
E +G +E + E D EA G ++ + ++ E P++ G + +
Sbjct: 1855 EAEGDAQEAEGEAQPESEDV----EAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPE 1910
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
A++ + + + + ++ +G+ + E + E EG + ES V ++++
Sbjct: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPES---EVIESQEAE 1967
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVED--- 830
+ + +SED + VE T + E + ++ P + + ++E P D
Sbjct: 1968 EEAQPESED-VEALEVEVETQEAEGEAQPESEDVE--APEAEGEMQEAEEEAQPESDGVE 2024
Query: 831 AGPTGANEDDSDVPAVVPLSEYDA-VEREKMEAQQAQKSAEQPEQKAATEVSKELSESQV 889
A P E+ +V +E DA E + +EA +A++ A++ E + + ES+
Sbjct: 2025 AQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE- 2083
Query: 890 HMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPT 949
+ A A+G E P +E +E EAE E + E P T
Sbjct: 2084 -DVDAQEAEG--------EAQPE------SEGVEAPEAEGEAQKAEGI-------EAPET 2121
Query: 950 VTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAE-EGTEASAAEETTEMVSAVSQ 1008
E PE+ EA+ E V A + G E EG EA AEE + +
Sbjct: 2122 EGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ---PELE 2178
Query: 1009 LTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQP 1068
++P+ EA P E G+ + E E Q L+ V EE P PE V P
Sbjct: 2179 GVEAPEAEGEAQPESE---GI-EAPEAEGEAQPELEGVEAPEAEEEAQP---EPEGVETP 2231
Query: 1069 VQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTP 1117
EA+ PE + E G KK + V D Q + + + TP
Sbjct: 2232 EAEGEAQ-PESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTP 2279
Score = 80.9 bits (198), Expect = 1e-14
Identities = 149/675 (22%), Positives = 243/675 (36%), Gaps = 105/675 (15%)
Query: 5 SSTEQRSPEQPPEGSSTPAEPEPSGGGPS----AEAAPDTTADPAIAASDPATKLLQKNG 60
+ +E EQ EG S E G G EAA DP + + + G
Sbjct: 1783 AGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEG 1842
Query: 61 QLST---------INGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRD 111
+ G A++ E Q + + G+ S++ E Q +
Sbjct: 1843 EAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE 1902
Query: 112 SEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIG 171
SE +++KE ++ V + +G++E + +E +E T+ ++ I
Sbjct: 1903 SEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962
Query: 172 FKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESE 231
++ +++ + + V+ L V+ + E A E++
Sbjct: 1963 SQE----------AEEEAQPESEDVEALEVEVETQE------------------AEGEAQ 1994
Query: 232 PK-QSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 290
P+ + E PE + +++ E P ++ +A + K EGEE QE E
Sbjct: 1995 PESEDVEAPEAEGEMQEAEEEAQPESDGVEA--QPKSEGEEAQEVE-------------- 2038
Query: 291 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKE-QEPEKVDTEEDGKAEVASEK 349
G T K T+G A +P+ D VEA E ++E QE E E +G+A SE
Sbjct: 2039 --GETQK---TEGDA---------QPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESED 2084
Query: 350 LTASE-QAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKI 408
+ A E + Q +E P E +K E + G P E E + +
Sbjct: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-----GIEAPEAEG 2139
Query: 409 EVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSV-PAEELVEMDAEPQEAEPAKELVKLK 467
E E E + E + E + E +E P E VE EA+P E ++
Sbjct: 2140 EAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAP 2199
Query: 468 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKK 527
E + +G + E+ PEGV E + + + +G + G KK
Sbjct: 2200 EAEGEAQPELEGVEAPEAEEEAQPEPEGV--ETPEAEGEAQPESEGE-------TQGEKK 2250
Query: 528 LSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEE---PEEITCLEKGLA 584
S + G G +E S + VP D P G++ P P G
Sbjct: 2251 GSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNC 2309
Query: 585 EVQQDGEAEE--GATSDGEKKREGVTPWASFKKMVTPKKRVRR-PSESDKEDELDKVKSA 641
Q+D E + G T + K G TP A +K R P S E E + S
Sbjct: 2310 -WQKDSENDHVLGDTRSPDAKSTG-TPHAE-------RKATRMYPESSTSEQEEAPLGSR 2360
Query: 642 TLSSTESTASEMQEE 656
T S ++QE+
Sbjct: 2361 TPEQGASEGYDLQED 2375
Score = 76.6 bits (187), Expect = 2e-13
Identities = 184/887 (20%), Positives = 309/887 (34%), Gaps = 143/887 (16%)
Query: 932 LTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEG 990
L E ++ EV EE + T E L E +T E L E V ET G +
Sbjct: 1292 LAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEG-LQEEGVQLEETKETEGEGQQ 1350
Query: 991 TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV----EGGVPDIEEQERRTQEVL--- 1043
E + EE E T EE ++EV EGG+ +E +E L
Sbjct: 1351 EEEAQLEEIEE--------TGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEE 1402
Query: 1044 -QAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAE---ASGLKKETDVVLKVDAQ 1099
+++ E S G G ED PVQ EA R AE A G ++ T+ +
Sbjct: 1403 GSVHGQELSEASSPDGKGSQED--DPVQEEEAGRASASAEPCPAEGTEEPTEP----PSH 1456
Query: 1100 EAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIP 1159
++T+P + G EK P T + T Q A +S + A+
Sbjct: 1457 LSETDPSASERQSGSQLEPGLEKPPGATMMGQEH---TQAQPTQGAAERSSSVACSAALD 1513
Query: 1160 PDSV-------ETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1212
D + +T ++ VA+ A Q +++++ E +
Sbjct: 1514 CDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLD------------QMAAELQ 1561
Query: 1213 AVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYAD 1272
AQ+ + + + +E E E+ ++T + G + +++
Sbjct: 1562 QDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSE 1621
Query: 1273 EKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAEC-----KKDDALELQSHAK 1327
P L +++ +S +++ + EG E C KK + ++
Sbjct: 1622 RTLGLGP----LSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMG 1677
Query: 1328 SPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAK 1387
+ P++ +Q ++ E H + E E T ++ S + +Q + G
Sbjct: 1678 ATRGPIKEAFDLQQILQRKRGE--HTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLS 1735
Query: 1388 EVSSL------EGSP------PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETA 1435
+ + EGS P LG+ E + + + +A +E + E
Sbjct: 1736 QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGE 1795
Query: 1436 NILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKG 1495
I E GET H E N A G D P G
Sbjct: 1796 GISERGETGGQGSGH--------EDNLQGEAAAGGDQDP--------------------G 1827
Query: 1496 LSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQ 1555
S EG + + ++ E +E E E E E ++
Sbjct: 1828 QSDGAEGIEAPEAEGEAQPESE-----------GVEAPEAEGDAQEAEGEAQP------- 1869
Query: 1556 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1615
+E+ E Q ++ ++ + + E EG E + ++ P T +
Sbjct: 1870 -------ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESV 1922
Query: 1616 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSV 1675
E E+ + S+ + EA E E EG T Q E V+ S+E A ++
Sbjct: 1923 EALETEGEDEPESE-GAEAQEAEEAAQ--EAEGQT----QPESEVIESQE----AEEEAQ 1971
Query: 1676 PEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQ 1735
PE + L +E E + + +DV+ PE + +A ES +
Sbjct: 1972 PESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEM---QEAEEEAQPESDGVEAQPK 2028
Query: 1736 KEKEDAQEVELQ----EGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E E+AQEVE + EG ESD P+A+EE Q+ E E ++E
Sbjct: 2029 SEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAE 2075
Score = 69.3 bits (168), Expect = 3e-11
Identities = 252/1209 (20%), Positives = 431/1209 (35%), Gaps = 199/1209 (16%)
Query: 650 ASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG----GPK 705
A+ E + S E+ ++ + +V E + K G EE K
Sbjct: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQL---EETKEGTEGEGLQEEAVQLEETK 1326
Query: 706 AMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRL 765
G ++ + + KET +G Q+ + Q E G + EGV E
Sbjct: 1327 TEEGLQEEGVQLEETKETEGEG-----QQEEEAQLEEIEETGGEGLQEEGVQLEE----- 1376
Query: 766 VTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK--Q 823
++E E + G +E + E EE V ++ PDGK Q
Sbjct: 1377 ----------VKEGPEGGLQGEALEEGLKE-EGLPEEGSVHGQEL---SEASSPDGKGSQ 1422
Query: 824 EQAPV--EDAGPTGANEDD-----SDVPAVVP--LSEYDAVEREKMEAQQAQKSAEQPEQ 874
E PV E+AG A+ + ++ P P LSE D E+ Q + E+P
Sbjct: 1423 EDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPP- 1481
Query: 875 KAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS-----------ASVTEPLE 923
AT + +E +++Q AA + A + + P W+S A + +
Sbjct: 1482 -GATMMGQEHTQAQP-TQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
Query: 924 QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA-----ELTPEAVTA 978
++ A L ++L++ +A E V + L ++ + + A E EA+T
Sbjct: 1540 ELRARWGLQDNDLLDQ--MAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTG 1597
Query: 979 A---ETAGPLGAEEGTE-ASAAEETTEMVSAVS-QLTDSP--DTTEEATPVQEVEGGVPD 1031
+T G SA E T + +S L D P T + +E EG
Sbjct: 1598 ELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEG---- 1653
Query: 1032 IEEQERRTQEVLQAVAEKVKEESQLPGTGGPE----DVLQPVQRAEAERPE-EQAEASGL 1086
E+ + ++ + ++ + T GP D+ Q +QR E + E AE +
Sbjct: 1654 --EEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPG 1711
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESI--ESSELVTTCQAETL 1144
K TD Q A+ G P + P V E E S+ + + L
Sbjct: 1712 KTHTDPTSTRTVQGAE----------GGLGP-GLSQGPGVDEGEDGEGSQRLNRDKDPKL 1760
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIV---EIHEEN--- 1198
+ M E+ + ET SE A+ + G +++ E HE+N
Sbjct: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGE----AEQEGEGISERGETGGQGSGHEDNLQG 1816
Query: 1199 EVASGT-----QSGGTEA-EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252
E A+G QS G E EA A+ E P + E E + E + + E
Sbjct: 1817 EAAAGGDQDPGQSDGAEGIEAPEAEGEAQP-------ESEGVEAPEAEGDAQEAEGEAQP 1869
Query: 1253 ETVSILSKTEGTQEADQYADEKTKDV-----PFFEGLEGSIDTGITVSREKVTEVALKGE 1307
E+ + + + + D +T + P EG E + E + AL+ E
Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAP-EAEKEAQPETESVEALETE 1928
Query: 1308 GTEEAECKKDDALELQSHAKSPPSPVEREM-VVQVEREKTEAEPTHVNEEKLEHETAVTV 1366
G +E E + +A E + A+ + E V++ + + EA+P + E LE E
Sbjct: 1929 GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE 1988
Query: 1367 SEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAE 1426
+E ++ + V P +G ++Q EA
Sbjct: 1989 AEGEAQPESEDVEAPEAEG-----------------------EMQEAEEEAQPESDGVEA 2025
Query: 1427 EEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPV 1486
+ K GE A +E GET + G A P D V P+ + +
Sbjct: 2026 QPKSEGEEAQEVE-GETQKTEGD----------------AQPESDGVEA-PEAEEE---- 2063
Query: 1487 IVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKV-SVAIEDLEPENGILELETK 1545
A +G + EGE +S++VD Q A E + S +E E E
Sbjct: 2064 ---AQEAEGEVQEAEGEAHP----ESEDVDAQEAEGEAQPESEGVEAPEAEG-------- 2108
Query: 1546 SSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQET--EKEGEEPQA 1603
++ + I + + E E +E + Q ++QDA E E EG E Q
Sbjct: 2109 EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE 2168
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
+ ++ P E E A G+A + + +E E+EG + + E P
Sbjct: 2169 AEEEAQPELEGVEAPE--AEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226
Query: 1664 EEEGGGAGTKSVPEDDGHALLAERIEKSL-VEPKEDEKGDDVDDPENQNSALADTDASGG 1722
E A ++ PE +G ++ + + + E+ + P ++ G
Sbjct: 2227 GVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGD 2286
Query: 1723 LTKESPDT-NGPKQKE--------KEDAQEVELQEGKVHSESDKAITPQAQEELQKQERE 1773
+ P + GP ++D++ + ++ TP A+ + + E
Sbjct: 2287 TPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPE 2346
Query: 1774 SAKSELTES 1782
S+ SE E+
Sbjct: 2347 SSTSEQEEA 2355
Score = 48.9 bits (115), Expect = 4e-05
Identities = 222/1092 (20%), Positives = 374/1092 (34%), Gaps = 151/1092 (13%)
Query: 207 EGAAGAGDHKDPSL---GAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAES--GQA 261
E AG +DP L GAG ++ + EE + S + S S G
Sbjct: 492 ERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGR 551
Query: 262 VEECKEEGEEKQEKEPSKSAESPTSPVTSETG--STFKKFFTQGWAGWRKKTSFRKPKED 319
+ C + + ++ + P SP S + S + TQG G + T +E
Sbjct: 552 PQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQG-QGTEQATGAAVTREP 610
Query: 320 EVEASEKKKEQE-----PEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY 374
V + E P + + G+ S AS + P P PR +
Sbjct: 611 LVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSR---ASAMSSPSSPGLGRVAPRGHPRH 667
Query: 375 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTE 434
+ + S +++ P P E+ Q+ V S+ RT+
Sbjct: 668 SHYRKDTHSPLDSSV--TKQVPRP------PERRRACQDGSVPRYSGSSSSTRTQASGNL 719
Query: 435 VEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDP--TQGADLSPDEKVLSKP 492
++GS+P+++L + PA + VSG P A + D +
Sbjct: 720 RPPSSGSLPSQDL--LGTSSATVTPA-----VHSDFVSGVSPHNAPSAGWAGDAGSRTCS 772
Query: 493 PEGVVSEVEMLSSQERMKVQGSPLKKL-FTSTGLKKLSGKKQKGKRGGGDEESGEHTQVP 551
P + S+ G + S+ L G+ ++G G H
Sbjct: 773 PAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVG----PHRSHCCSQ 828
Query: 552 ADSPDSQEEQKGESSASS-------PEEPEEITCLEKGLAEVQQDGEAEEG-ATSDGEKK 603
+ +QE Q+G S +S P P C ++ + G + + A G
Sbjct: 829 PGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSP 888
Query: 604 REGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKG---- 659
+EG RR S S + TL S + QEE G
Sbjct: 889 QEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRS--GGGPQGQEEASGVSPS 946
Query: 660 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK 719
S+ PE R+ ++ E ++ G++ GP+ GD + G+
Sbjct: 947 SLPRSSPEAVVREWLDNIPEEPILMTYELADETT-GAAGGGLRGPEVDPGDDHSLEGLGE 1005
Query: 720 DKETGTDGILAGSQEHDPGQGSSSPEQAGS--------PTEGEGVSTWESFKRLVTPRKK 771
+ G + E DPGQ PE G+ P GEGV + P
Sbjct: 1006 PAQAGQQSL-----EGDPGQ---DPEPEGALLGSSDTGPQSGEGV------PQGAAPEGV 1051
Query: 772 SKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDA 831
S++ E D A +G S PG+ + I + + G ++ RP E +
Sbjct: 1052 SEAP-AEAGADREAPAGCRVSL-RALPGRVSASTQIMRALMGSKQGRPSSVPEV-----S 1104
Query: 832 GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL------S 885
P S + L+ E + + + P + +SK+L
Sbjct: 1105 RPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVG 1164
Query: 886 ESQVH------MMAAAVAD-GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLE 938
E Q+ + A+ D G+ A T E +P+ S E+++
Sbjct: 1165 EDQLDSGLWELTWSQALPDLGSHAMT--ENFTPTSSSGVDISSGSGGSGESSVPCAMDGT 1222
Query: 939 REVIAEEEPPTVTEPLPENR--EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 996
E P + P++R E+ GD + P + A A +E A
Sbjct: 1223 LVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDE------A 1276
Query: 997 EETTEMVSAVSQLTD-SPDTTEEATPVQEVEGGVPD-------IEEQERRTQEVLQAVAE 1048
E +E A S L + +T +E ++E + G ++ +E +T+E LQ
Sbjct: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGV 1336
Query: 1049 KVKEESQLPGTGGPEDVLQPVQRAEAERPE-EQAEASGLKKETDVVLKVDAQEAKTEPFT 1107
+++E + G G E+ EA+ E E+ GL++E V +E K P
Sbjct: 1337 QLEETKETEGEGQQEE--------EAQLEEIEETGGEGLQEE-----GVQLEEVKEGP-- 1381
Query: 1108 QGKVVGQTTPESFEKAPQVTE-SIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP 1166
+G + G+ E ++ E S+ EL +A + G SQE + P
Sbjct: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQEL---SEASSPDGKGSQE------------DDP 1426
Query: 1167 TDSETDG--STPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAP 1224
E G S A GT + E E + ++ + G++ E E+PP
Sbjct: 1427 VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLE---PGLEKPPG- 1482
Query: 1225 SSFVFQEETKEQ 1236
++ + QE T+ Q
Sbjct: 1483 ATMMGQEHTQAQ 1494
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 108 bits (271), Expect = 4e-23
Identities = 300/1421 (21%), Positives = 533/1421 (37%), Gaps = 242/1421 (17%)
Query: 49 SDPATKLLQ-----KNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVI 103
++PA K+++ + Q + + G+ + L + L QK L Q V+
Sbjct: 478 ANPAEKIIRVLFPGNSTQYNILEGLEKLKHLDFLKQPLATQKD-------LTGQVPTPVV 530
Query: 104 V-TEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQP 162
T++ QR S + + K + +KS + + +EETPE+ + + + +P
Sbjct: 531 KQTKLKQRADSRESLKPAAKPLPSKS-----VRKESKEETPEV--------TKVNHVEKP 577
Query: 163 TESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVK----KDEGEGAAGAGDHKDP 218
+ ++ + K VKKDK K +T +T K K+E K
Sbjct: 578 PKVESKE------------KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQA 625
Query: 219 SLGAGEAASKESEPKQSTEKPE------ETLKREQSHAEISPPAESGQ------AVEECK 266
+ +AA +++ K++ KPE E K+E + E P + + +E K
Sbjct: 626 TDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK 685
Query: 267 EEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK 326
+E +++++KEP K + T P E KK KK ++ KE + E +
Sbjct: 686 KEIKKEEKKEPKKEVKKETPP--KEVKKEVKK--------EEKKEVKKEEKEPKKEIKKL 735
Query: 327 KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE--KVELPSEEQ 384
K+ + E K K+ E++ ++ + +A +P+ + + K E + E
Sbjct: 736 PKDAKKSSTPLSEAKKPAALKPKVPKKEES-VKKDSVAAGKPKEKGKIKVIKKEGKAAEA 794
Query: 385 VSGSQGPSEEKPAPLAT---EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGS 441
V+ + G A +A E+ E + ++ E + EV+ T
Sbjct: 795 VAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDI 854
Query: 442 VPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV- 500
P EL+E + + +E EP + V KE + T+G SPDE + + EG +
Sbjct: 855 KPQLELIEDEEKLKETEPVEAYVIQKE-----REVTKGPAESPDEGITTTEGEGECEQTP 909
Query: 501 EMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEE 560
E L E+ V ++K + G G EES E + D +E+
Sbjct: 910 EELEPVEKQGVD-----------DIEKFEDE------GAGFEESSE-------TGDYEEK 945
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGE----KKREGVTPW--ASFK 614
+ E + E+ EE C+ A E EE A ++ + +KRE V + +
Sbjct: 946 AETEEAEEPEEDGEEHVCVS---ASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEE 1002
Query: 615 KMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK----PEEPK 670
M ++ ++ DE DK + A E E ++ + V++ EE
Sbjct: 1003 DMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQY 1062
Query: 671 RKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILA 730
+ T +G+ SS +E P + +DE +++E + A
Sbjct: 1063 GFLTTPTKQ-----LGAQSPGREPASSIHDETLPGGSESEATASDE--ENREDQPEEFTA 1115
Query: 731 GSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVE 790
S G S+ E + PT + +ST R V + + + E S++ + + E
Sbjct: 1116 TS-----GYTQSTIEISSEPTPMDEMST----PRDVMSDETNNEETESPSQEFVNITKYE 1166
Query: 791 HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLS 850
S E K + F G + DGK A P + E+D
Sbjct: 1167 SSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDK--------- 1217
Query: 851 EYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERS 910
++ A + A E KA+T + + S S V + + +S
Sbjct: 1218 ----------FSRSALRDAYCSEVKASTTLDIKDSISAV-----------SSEKVSPSKS 1256
Query: 911 PSWISASVTEPLEQVE-AEAAL---LTEEVLEREVIAEEEP--PTVTEPLPENREARGDT 964
PS +S S PLE+ E ++ LT ++ AE P P VT+ + E A +
Sbjct: 1257 PS-LSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPED 1315
Query: 965 VVSEAELTPEAVTAAETAGPLGAEEGTEASA--AEETTEMVSAVS---QLTDSPDTTEEA 1019
E ++VT + P E S+ E E AV + +D+ D E A
Sbjct: 1316 KTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERA 1375
Query: 1020 TPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAE------ 1073
+ V ++ VPD E + EKV + P G E + A+
Sbjct: 1376 S-VSPMDEPVPDSE-----------SPIEKVLSPLRSPPLIGSESAYESFLSADDKASGR 1423
Query: 1074 -AERPEEQA--------EASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAP 1124
AE P E+ + S + + T L D QE K+ F K E F +
Sbjct: 1424 GAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIK-------EDFGQEK 1476
Query: 1125 QVTESIE--SSELVTTCQAETLAGVKSQEMVMEQ--AIPPD---SVETPTDSETDGSTPV 1177
+ T+ +E SS+ L V ++ + Q + D S+ T S+ +TPV
Sbjct: 1477 K-TDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSD-KSATPV 1534
Query: 1178 ADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQS 1237
+ A T H E + T S T + P + P+ + V + E
Sbjct: 1535 DEGVAEDTYS-------HMEGVASVSTASVATSSFPEPTTDDVSPSLHAEVGSPHSTE-- 1585
Query: 1238 KMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSRE 1297
++D+L + V+T + +TE + ++ + P F T + R
Sbjct: 1586 -VDDSLSVS----VVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPVQDHRS 1640
Query: 1298 KVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV-EREKTEAE--PTHVN 1354
+ + +++ E + + +L + +SP P V+ + E TE + P+ +
Sbjct: 1641 EQSSMSI-----EFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQ 1695
Query: 1355 EEKLEHETAVTVSEEVS----KQLLQTVNVPIIDGAKEVSS 1391
+ L H+ + EE S L + ++V ++ + SS
Sbjct: 1696 DSSLSHK--IPPMEEPSYTQDNDLSELISVSQVEASPSTSS 1734
Score = 84.3 bits (207), Expect = 9e-16
Identities = 307/1496 (20%), Positives = 533/1496 (35%), Gaps = 203/1496 (13%)
Query: 146 IEQIPSSESNLEELTQPTES-QANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKD 204
+E S S+ E+LT+ E +A ++ K K + ++K ++ + V+ ++K
Sbjct: 823 LEAERSLMSSPEDLTKDFEELKAEEVDVTKDIK-PQLELIEDEEKLKETEPVEAYVIQK- 880
Query: 205 EGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE 264
E E G + D + E E E +Q+ E+ E K Q +I + G EE
Sbjct: 881 EREVTKGPAESPDEGITTTEG---EGECEQTPEELEPVEK--QGVDDIEKFEDEGAGFEE 935
Query: 265 CKEEG--EEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 322
E G EEK E E ++ E + S + A R+ +E
Sbjct: 936 SSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVAS 995
Query: 323 ASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 382
++ +E E + E G+AE + E+A ++ AE A E EYE ++ +E
Sbjct: 996 GDDRAEEDMDEAI---EKGEAE------QSEEEADEEDKAEDAREE----EYEPEKMEAE 1042
Query: 383 EQV------SGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVE 436
+ V + G +EE+ L T + E + +H T+ +E + T +
Sbjct: 1043 DYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASD 1102
Query: 437 E----------TAGSVPAEELVEMDAEP-------------------QEAE-PAKELVKL 466
E TA S + +E+ +EP +E E P++E V +
Sbjct: 1103 EENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNI 1162
Query: 467 K--ETCVSGEDPTQGADLSP---------DEKVLSKPPEGVVSEVEMLSSQERMKVQGSP 515
E+ + ++ ++ AD++P + K S + SS E K S
Sbjct: 1163 TKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSA 1222
Query: 516 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDS----QEEQKGESSASSPE 571
L+ + S +K + K E ++ P+ SP ++ GE S +
Sbjct: 1223 LRDAYCSE-VKASTTLDIKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSL 1281
Query: 572 EPEEI-TCLEKGLAEVQQDGE---AEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPS 627
P EI E +A V + EE S +K E V+P S + P+
Sbjct: 1282 TPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPT 1341
Query: 628 ESDKE----DELDKVKSATLSSTESTASEMQEEMKGS-VEEPKP--EEPKRKVDTSVSWE 680
+ + ++K + +S S A + E S ++EP P E P KV + +
Sbjct: 1342 DEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSP 1401
Query: 681 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK-DKETGTDGILAGSQEHDPGQ 739
LI GS S+ D+ G A +K+ + G D+ + + + S D +
Sbjct: 1402 PLI--GSESAYESFLSADDKASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQE 1459
Query: 740 GSSSP-----EQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTP 794
G S+ E G + + V S L +K + + S GS E
Sbjct: 1460 GKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDERKLGDVSPTQIDVSQFGSFKE---- 1515
Query: 795 DTEPGKEESWVSIKKFIP---GRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL-- 849
DT+ E VS K P G + + A V A ++ + V P
Sbjct: 1516 DTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASVSTASVATSSFPEPTTDDVSPSLH 1575
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAA---TII 906
+E + +++ + + P TE+S E M + + A T +
Sbjct: 1576 AEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSKEECPRPMSISPPDFSPKTAKSRTPV 1635
Query: 907 EERSPSWISASVTEPLEQVEAEAAL------------------LTE----EV------LE 938
++ S S+ E E A+ +TE EV ++
Sbjct: 1636 QDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPDHPTVGAGVLHITENGPTEVDYSPSDMQ 1695
Query: 939 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTAAETAGPLGAEEGTEASA 995
++ + PP ++ + VS+ E +P A T ++ A PL + ++ +
Sbjct: 1696 DSSLSHKIPPMEEPSYTQDNDLSELISVSQVEASPSTSSAHTPSQIASPLQEDTLSDVAP 1755
Query: 996 AEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQ 1055
+ + S S+ S + E+ +P ++ P E VKE++
Sbjct: 1756 PRDMSLYASLTSEKVQSLEG-EKLSPKSDISPLTP--RESSPLYSPTFSDSTSAVKEKTA 1812
Query: 1056 LPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQT 1115
+ P+ A AE +A + + L D E + GK G
Sbjct: 1813 TCHSSSSP----PIDAASAEPYGFRASVLFDTMQHHLALNRDLSTPGLEKDSGGKTPGDF 1868
Query: 1116 T-----PESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ PE ++P E + T + + G +++ P DS + E
Sbjct: 1869 SYAYQKPEETTRSPD-EEDYDYESYEKTTRTSDVGGYYYEKIERTTKSPSDSGYS---YE 1924
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
T G T D D EI E+ + T G + + + PP S + ++
Sbjct: 1925 TIGKTTKTPEDG------DYSYEIIEKT---TRTPEEGGYSYDISEKTTSPPEVSGYSYE 1975
Query: 1231 EETKEQSKMEDTLE-HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEG-SI 1288
+ + + ++D + D E T+ S Y+ E T+ + F EG S
Sbjct: 1976 KTERSRRLLDDISNGYDDSEDGGHTLGDPS----------YSYETTEKITSFPESEGYSY 2025
Query: 1289 DTGITVSREKVT-----EVALKGEGTEEAECKKDDALELQSHA-KSPPSPVEREMVV--- 1339
+T +R T E A K T +A + +L A K PS +++ +
Sbjct: 2026 ETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLV 2085
Query: 1340 ---QVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1396
+ + KTE P+ +N LE + +EE K L Q+ P G K+
Sbjct: 2086 SSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDET 2145
Query: 1397 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1456
PP E A S+ + EE + ANI E + ++
Sbjct: 2146 PPTSVSESA--------PSQTDSDVPPETEECPSITADANI-----DSEDESETIPTDKT 2192
Query: 1457 SSEKNEDFAAHPGEDAVPT--GPDCQAKSTPVI-VSATTKKGLSSDLEGEKTTSLK 1509
+ K+ D P +D P+ PD + + K L DL+ EKT + K
Sbjct: 2193 VTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLK-EKTKTKK 2247
Score = 71.6 bits (174), Expect = 6e-12
Identities = 250/1215 (20%), Positives = 426/1215 (35%), Gaps = 255/1215 (20%)
Query: 238 KPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFK 297
K + +R S + P A+ + KE EE E E P + E
Sbjct: 531 KQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKE------ 584
Query: 298 KFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLT-ASEQA 356
K +K K + E E+E + KAEVA ++ T +A
Sbjct: 585 ------------KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKA 632
Query: 357 HPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVV 416
++ + + + + E+ E P +E +E P+ E +K EV ++EV
Sbjct: 633 AKEKTVKKETKVKPEDKKEEKEKPKKEVAK------KEDKTPIKKEEKPKKEEV-KKEVK 685
Query: 417 AEVHVSTVEERTEEQKTEV--EETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGE 474
E+ +E +E K E +E V EE E+ E E EP KE+ KL +
Sbjct: 686 KEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKE--EKEPKKEIKKLPKDAKKSS 743
Query: 475 DPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQK 534
P LS +K + P+ E +KK + G K GK +
Sbjct: 744 TP-----LSEAKKPAALKPKVPKKE--------------ESVKKDSVAAGKPKEKGKIKV 784
Query: 535 GKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE 594
K+ G E+ + + G ++ +E E L ++ +D E
Sbjct: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFE--- 841
Query: 595 GATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDE------LDKVKSATLSSTES 648
E K E V K + P+ + E KE E + K + T ES
Sbjct: 842 ------ELKAEEV----DVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAES 891
Query: 649 -----TASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGG 703
T +E + E + + EE +P E K+ VD +E DE G
Sbjct: 892 PDEGITTTEGEGECEQTPEELEPVE-KQGVDDIEKFE------------------DEGAG 932
Query: 704 --PKAMGGDHQ---KADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST 758
+ GD++ + +EA + +E G + + + +H SPTE E
Sbjct: 933 FEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH-------------SPTEDE---- 975
Query: 759 WESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKR 818
ES K ++ + + EK E +G D K E+ S +
Sbjct: 976 -ESAK------AEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQS-------EEEAD 1021
Query: 819 PDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREK--MEAQQAQKSAEQPEQKA 876
+ K E A E+ P +D + V +E E + + Q A+ P ++
Sbjct: 1022 EEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREP 1081
Query: 877 ATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISAS--VTEPLEQVEAEAALLTE 934
A+ + E A A + R E P +A+ T+ ++ +E + E
Sbjct: 1082 ASSIHDETLPGGSESEATASDEENR------EDQPEEFTATSGYTQSTIEISSEPTPMDE 1135
Query: 935 EVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEAS 994
R+V+++E TE ++E T + + E A+ G EG++
Sbjct: 1136 MSTPRDVMSDETNNEETE--SPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTD 1193
Query: 995 AAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQ-AVAEKVKEE 1053
A TD D A+ + P E+++ ++ L+ A +VK
Sbjct: 1194 A--------------TDGKDYNASASTISP-----PSSMEEDKFSRSALRDAYCSEVKAS 1234
Query: 1054 SQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVG 1113
+ L D+ + +E+ S +
Sbjct: 1235 TTL-------DIKDSISAVSSEKVSPSKSPS---------------------------LS 1260
Query: 1114 QTTPESFEKAP----QVTESIESSELVTTCQAET--LAGVKSQEMVMEQAIPPD----SV 1163
+ P EK P V S+ +E+ + +AE ++ +QE+V E P+ V
Sbjct: 1261 PSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEV 1320
Query: 1164 ETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPA 1223
+P+ S T + + +P T +K H EV E+PPA
Sbjct: 1321 VSPSQSVTGSAGHTPYYQSP-TDEKSS----HLPTEVI-----------------EKPPA 1358
Query: 1224 -PSSFVFQEETKEQ-----SKMEDTLEHTDKEV--------SVETVSILSKTEGTQEADQ 1269
P SF F + E S M++ + ++ + S + S E AD
Sbjct: 1359 VPVSFEFSDAKDENERASVSPMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADD 1418
Query: 1270 YADEKTKDVPFFE--GLEGSIDTGITVSREKVTEV---ALKGEGTEEAECKKDDALELQS 1324
A + + PF E G +GS D VS T + +G+ T+ A K+D E ++
Sbjct: 1419 KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKT 1478
Query: 1325 HAKSPPSPVEREMVVQVEREKTEAEPTHVNEEK---LEHETAVTVSEEVSKQLLQTVNVP 1381
S + + ER+ + PT ++ + + +T +++SE T P
Sbjct: 1479 DDVEAMS--SQPALALDERKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSAT---P 1533
Query: 1382 IIDGAKE--VSSLEG 1394
+ +G E S +EG
Sbjct: 1534 VDEGVAEDTYSHMEG 1548
Score = 35.8 bits (81), Expect = 0.38
Identities = 102/451 (22%), Positives = 165/451 (36%), Gaps = 90/451 (19%)
Query: 233 KQSTEKPEET-LKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSE 291
+++T PEE + S SPP SG + E K E + + S + SE
Sbjct: 1944 EKTTRTPEEGGYSYDISEKTTSPPEVSGYSYE--KTERSRRLLDDISNGYDD------SE 1995
Query: 292 TGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLT 351
G + + K TSF + + E S K E +EK+T
Sbjct: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTPDTSTYCYE------TAEKIT 2049
Query: 352 ASEQA--------------HPQEPAESAHEPRL----SAEYE--KVEL------PSEEQV 385
+ QA + P+E+ + L S EY+ K EL P+ +
Sbjct: 2050 RTPQASTYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEW 2109
Query: 386 SGSQGPSEEKPAPL-----ATEVFDEKIEVHQEEVVAEVHVS-TVEERTEEQKTEVEETA 439
S+ P+EE PL A K + Q + VS + +T+ E
Sbjct: 2110 FASEEPTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEEC 2169
Query: 440 GSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSE 499
S+ A+ ++ + E E P + V K P D SP + P+ + +
Sbjct: 2170 PSITADANIDSEDE-SETIPTDKTVTYKHM---DPPPAPVQDRSPSPR----HPDVSMVD 2221
Query: 500 VEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQE 559
E L+ ++ + LKK +K K K+ G T+ + SP +
Sbjct: 2222 PEALAIEQNL------------GKALKKDLKEKTKTKKPG--------TKTKSSSPVKKS 2261
Query: 560 EQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTP 619
+ K + A+SP+ GL E +++ + KK+E V A K TP
Sbjct: 2262 DGKSKPLAASPKPA--------GLKE-----SSDKVSRVASPKKKESVEKAA--KPTTTP 2306
Query: 620 KKRVRRPSESDKEDELDKVKSATLSSTESTA 650
+ + R E DKE + SA+ S+ +TA
Sbjct: 2307 EVKAARGEEKDKETKNAANASASKSAKTATA 2337
Score = 35.4 bits (80), Expect = 0.50
Identities = 42/192 (21%), Positives = 81/192 (42%), Gaps = 11/192 (5%)
Query: 1597 EGEEPQASAQDETPITSAKEES--ESTAVGQAHSDISKDMSEASEKTMTVEVEG-STVND 1653
+ E A P S ++ES E+ V + + E+ EK M + + T
Sbjct: 540 DSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETK 599
Query: 1654 QQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSA 1713
+ E +PS+EE + + EK++ + + + D ++ E
Sbjct: 600 PSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKE 659
Query: 1714 LADTDASGGLTKESPDTNGPKQKE--KEDAQEVELQEGKVHSESDKAITP--QAQEELQK 1769
+A + + KE PK++E KE +E++ +E K + K TP + ++E++K
Sbjct: 660 VAKKEDKTPIKKEEK----PKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKK 715
Query: 1770 QERESAKSELTE 1781
+E++ K E E
Sbjct: 716 EEKKEVKKEEKE 727
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 101 bits (252), Expect = 6e-21
Identities = 294/1530 (19%), Positives = 551/1530 (36%), Gaps = 220/1530 (14%)
Query: 321 VEASEKKKEQEPEKVDTEEDGKA-EVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVEL 379
V A+ + KEQ +K + ++ + SE ++ E A L A+ +V
Sbjct: 24 VRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDA---ALQAKKTRVSD 80
Query: 380 PSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETA 439
P +S S+ EE+ A T ++ V+ S+++E+ + + + +T
Sbjct: 81 P----ISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTG 136
Query: 440 GSVP-------AEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKP 492
S+P L+ + + AEP+ + ET G P GA P +
Sbjct: 137 NSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG---MVSA 193
Query: 493 PEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES--GEHTQV 550
+ S + SS + V+ +K+ + + KG G G + G+ V
Sbjct: 194 GQADSSSEDTSSSSDETDVEVKASEKILQV----RAASAPAKGTPGKGATPAPPGKAGAV 249
Query: 551 PADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGV 607
+ + + E+ ESS+ + EE T K L + + G+ + GA S K+ R+G
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 309
Query: 608 TPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 667
P K K E D + ++ S + ++ S +++ + P E
Sbjct: 310 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKE 368
Query: 668 EPKRKVDTSVSWE-----ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 722
P++ + + A + VG ++ +R S + + + GK +
Sbjct: 369 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 428
Query: 723 TGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSED 782
+ G G G P + G T V WE + S+S EE S+
Sbjct: 429 VKPASTM-GMGPLGKGAGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDS 478
Query: 783 SIAGSGVEHSTPDT-EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDS 841
S + P P +E+S +I + +P + P + AGP
Sbjct: 479 S------DGEVPTAVAPAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ---- 521
Query: 842 DVPAVVPLSEYDAVEREK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
V A P+ ++ E M A QA+ + + P+ KA + + + ++V
Sbjct: 522 -VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 580
Query: 891 MMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTV 950
+ +A T SP+ S +V ++ +++ E +EEE +
Sbjct: 581 PVRVGTQAPRKAGTAT---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGL 631
Query: 951 TEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLT 1010
+ + + V A + + TA L + G T V A Q
Sbjct: 632 AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ-- 682
Query: 1011 DSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPV 1069
+ +++EE + +E ++ ++TQ A + GT P V+
Sbjct: 683 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAA 739
Query: 1070 QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTES 1129
+A+ P + + + V+ + A QT PE E + E
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEE 797
Query: 1130 IESSELVTTCQAETLAGVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQ 1187
+S E +AETLA VK + A+ P +S G+ P PG T
Sbjct: 798 SDSEE-----EAETLAQVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTG 843
Query: 1188 KDEIVEIHEENEVASGTQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE 1244
+++ +S +S G A AQ +PP +F + + + T
Sbjct: 844 PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPA 899
Query: 1245 HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVAL 1304
+ T +E T + E +P + L I T + +A
Sbjct: 900 QAQ---AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP 956
Query: 1305 KG---------EGTEEAECKKDDALELQSHAKSPPS-PVEREMVVQVEREKTEAEPTHVN 1354
K E + ++ KK + Q K+P S P+ + + + ++ +EA+P
Sbjct: 957 KASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVAR 1016
Query: 1355 EEKLEH-ETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQ 1413
+ ++AV S Q AK + L P + ++A
Sbjct: 1017 TQPSSGVDSAVGTLPATSPQSTSVQ-------AKGTNKLRKPKLPEV--QQATKAPESSD 1067
Query: 1414 SSEASFTLTAAAEEEKVLGETANILETGETL--EPAGAHLVLEEKSSEKNEDFAAHPGED 1471
SE S ++ +EE+ GE ++ TL P+ ++EE ++E +ED P +
Sbjct: 1068 DSEDSSDSSSGSEED---GEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQS 1124
Query: 1472 AVP-------TGPDCQA-KSTPVIVSA---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVA 1520
+ T + QA K+TP + S+ ++ D +G++ + + + +
Sbjct: 1125 LLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTG 1184
Query: 1521 CQEVKVSVAIE-DLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQ 1579
+E + +P+ G + + L NI Q + Q +E Q Q
Sbjct: 1185 GKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQ---------PWPLNEAQVQ 1235
Query: 1580 AHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMS---- 1635
A V+K ++ QE +K + + S++ K + A S K +
Sbjct: 1236 ASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG 1295
Query: 1636 -EAS---EKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA----GTKSVPEDDGHALLAER 1687
EAS EKT T +G D+ +V E++G G+ G K PE E
Sbjct: 1296 GEASVSPEKTSTTS-KGKAKRDKASGDV---KEKKGKGSLGSQGAKDEPE--------EE 1343
Query: 1688 IEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQ 1747
++K + +G D +P+++ K+K+K D ++ + +
Sbjct: 1344 LQKGM----GTVEGGDQSNPKSK-----------------------KEKKKSDKRKKDKE 1376
Query: 1748 EGKVHSESDKAITPQAQEELQKQERESAKS 1777
+ + ++ KA T ++ QK++++ K+
Sbjct: 1377 KKEKKKKAKKASTKDSESPSQKKKKKKKKT 1406
Score = 72.8 bits (177), Expect = 3e-12
Identities = 230/1181 (19%), Positives = 400/1181 (33%), Gaps = 242/1181 (20%)
Query: 238 KPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFK 297
K EE + +S P + ++ EE +EE E + K + A + +S + ++ S+ K
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEE-EEEAEAETAKATPRLASTNSSVLGADLPSSMK 122
Query: 298 -KFFTQGWAGWRKKTSFRKPKEDEVEAS-----EKKKEQEPEK-----VDTEEDGKAEV- 345
K + + S P + A+ +K EP +TEE+G
Sbjct: 123 EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
Query: 346 ---ASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEE---QVSGSQGPSEEKPAPL 399
A + ++ QA S+ + S++ VE+ + E QV + P++ P
Sbjct: 183 GAAAKPGMVSAGQAD-----SSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKG 237
Query: 400 ATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEET-------------------AG 440
AT K + A E +EE EET A
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 297
Query: 441 SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL--SKPPEGVVS 498
S PA+E A P V + ED ++ S E+ P G
Sbjct: 298 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 357
Query: 499 EVEMLSS--QERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPD 556
+V S+ +E + +P T ++ KQ+ EES + A
Sbjct: 358 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 417
Query: 557 SQEEQKGESSASSPEEPEEITCLEKGLAEVQ-----------QDGEAEEGATSDGEKKRE 605
+Q + G+S P + L KG V Q G+ EE + S E+ +
Sbjct: 418 AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 606 ---GVTPWA-------------SFKKMVTPKK-------------RVRRPSESDKEDELD 636
G P A K +P K + +P ++ + E
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE-- 535
Query: 637 KVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE-ALICVGSSKKRARRG 695
S + S E+ A+ + K +++ P+ + +K +T+ S + A + VG+ R
Sbjct: 536 -ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGT 594
Query: 696 SSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEG 755
++S P GG + P + SSS E++ S E G
Sbjct: 595 ATSPAGSSPAVAGGTQR------------------------PAEDSSSSEESDSEEEKTG 630
Query: 756 VSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRR 815
++ V K L+ K+ + T PG
Sbjct: 631 LAV------TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG---------------- 668
Query: 816 KKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 875
K P Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAK 726
Query: 876 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ----------- 924
+A AA ++RSPS + V P
Sbjct: 727 GT---------------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 771
Query: 925 -------VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE 974
A+A EE E E +EEE T+ + P + + ++ A+ +P
Sbjct: 772 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPR 831
Query: 975 ---AVTAAETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT- 1016
A T GP A+ G + S++EE+ A + +T + P+ +
Sbjct: 832 KGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSP 891
Query: 1017 --EEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT--------------- 1059
ATP Q P + R ++ ++ + + ++E +P T
Sbjct: 892 AGPAATPAQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 948
Query: 1060 GGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQG--KVVGQTTP 1117
+ A A +E + S KK+ +V + + P TQ KV+ Q
Sbjct: 949 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKAS 1008
Query: 1118 ESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPV 1177
E+ + S V T A S + QA + + P E +T
Sbjct: 1009 EAQPPVARTQPSSGVDSAVGTLPA------TSPQSTSVQAKGTNKLRKPKLPEVQQAT-- 1060
Query: 1178 ADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQS 1237
AP ++ E + ++ +SG++ G + + P PS + ++
Sbjct: 1061 ---KAPESSDDSE-----DSSDSSSGSEEDGEGPQGAKSAHTLGPTPS--------RTET 1104
Query: 1238 KMEDT-LEHTDKEVSVETVSILS--KTEGTQEADQYADEKT 1275
+E+T E ++ +V + S+LS T G A+ A + T
Sbjct: 1105 LVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKAT 1145
Score = 60.8 bits (146), Expect = 1e-08
Identities = 274/1391 (19%), Positives = 480/1391 (34%), Gaps = 235/1391 (16%)
Query: 3 AGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPAT--------- 53
A + T + +P SS PS A+A + + PAT
Sbjct: 94 AEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLS 153
Query: 54 -KLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDS 112
K +K+ + S + + E +EG + GA G +++ + + D
Sbjct: 154 GKSPRKSAEPSANTTLVSETE---EEGSVPAF-GAAAKPGMVSAGQADSSSEDTSSSSDE 209
Query: 113 EDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPS--SESNLEELTQPTESQANDI 170
DV + S+K + ++A G+ TP + + S++ + + +ES + +
Sbjct: 210 TDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEE- 268
Query: 171 GFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKES 230
D E+ + L K G K +GA A +KES
Sbjct: 269 ---------------SSDSEEETPAAKALLQAKASG---------KTSQVGAASAPAKES 304
Query: 231 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 290
K + P + A+ E Q+ E + +E+ P+++ S +P
Sbjct: 305 PRKGAAPAPPGKTGPAVAKAQAGKREEDSQS----SSEESDSEEEAPAQAKPSGKAPQVR 360
Query: 291 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKL 350
+ K+ +G A + + + +V E+ E+ D++ + A + + ++
Sbjct: 361 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 420
Query: 351 TASEQAHPQEPAE---------------------SAHEPRLSAEYEKVELPSEEQVSGSQ 389
++ +PA + ++ E E SEE S
Sbjct: 421 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSD 480
Query: 390 GPSEEKPAPLATEVFDEKIEVHQEEVVAE--------VHVSTVEERTEEQKTEVEETAGS 441
G AP + ++ A+ V V E+ + EE++ S
Sbjct: 481 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 540
Query: 442 VPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP-------DEKV------ 488
+EE Q A+PA ++ + K C + T A ++P K
Sbjct: 541 ADSEEAPAAMTAAQ-AKPALKIPQTK-ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 598
Query: 489 ----------LSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLK-KLSGKKQKGKR 537
+P E S E S +E+ + + + GL+ K + KG
Sbjct: 599 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 658
Query: 538 GGG------DEESGEHTQVPA----DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQ 587
G G + TQV A DS S+EE E +A+SP + + T ++K A+
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK--TSVKKTQAKAN 716
Query: 588 QDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKR--VRRPSESDKEDELDKVKSATLSS 645
A + VT A K+ K + VR P S ++
Sbjct: 717 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR-GPASVPSVGK 775
Query: 646 TESTASEMQ---EEMKGSVEEPKPEEPKRKVDTSV-----SWEALICVGSSKKRARRGSS 697
+TA++ Q EE GS EE E + + V + + + +K+ R+G++
Sbjct: 776 AVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 835
Query: 698 SDEEG--GPKAMGGDHQKADEAGKDKETGTDGILAGSQEH-----------DPGQGSSSP 744
G GP A Q D +E+ +DG + DP + + P
Sbjct: 836 PTPPGKTGPSAAQAGKQD-DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGP 894
Query: 745 EQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTE---PGKE 801
A +P + + S TPRK S E + S + S E P T+ PG
Sbjct: 895 --AATPAQAQAAS---------TPRKARAS--ESTARSSSSESEDEDVIPATQCLTPGIR 941
Query: 802 ESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKME 861
+ V++ P AP ++++ S + D ++E
Sbjct: 942 TNVVTM-----------PTAHPRIAPKASMAGASSSKESSRIS--------DGKKQEGPA 982
Query: 862 AQQAQKS-AEQPEQKAATEV-SKELSESQVHMMAAAVADGTRAAT-IIEERSPSWISASV 918
Q ++K+ A P +AA +V +++ SE+Q + + G +A + SP S
Sbjct: 983 TQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTS--- 1039
Query: 919 TEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAE--LTPEAV 976
V+A+ L + + E + T ++ E D+ E P+
Sbjct: 1040 ------VQAKGT----NKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGA 1089
Query: 977 TAAETAGPLGAEEGT--EASAAEETTEMVSAVSQLTDSPDTTEEATPV-QEVEGGVPDIE 1033
+A T GP + T E +AAE + + V A SQ S T TP + P ++
Sbjct: 1090 KSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLD 1149
Query: 1034 EQERRTQEVLQAVAEKVKEESQ--------LPGTGGPEDV--LQPVQRAEAERPEEQAEA 1083
+ + K+E++ P TGG E P + + ++ +A
Sbjct: 1150 SSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1209
Query: 1084 SGLKKETDVV------------LKVDAQEAK--TEPFTQ-GKVVGQTTPESFEKAPQVTE 1128
S L ++++ +V A K TE Q K V TT ES K + +
Sbjct: 1210 STLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRK 1269
Query: 1129 SIESSELVTTCQAETLAGVKSQEMVM----EQAIPPDSVETPTDSETDGSTPVADFDAPG 1184
S + A T K +++ E ++ P+ +T T S+ A D
Sbjct: 1270 RKLSGDQPA---ARTPRSKKKKKLGAGEGGEASVSPE--KTSTTSKGKAKRDKASGDVKE 1324
Query: 1185 TTQKDEI------VEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSK 1238
K + E EE + GT GG ++ P K+ +E KE+ K
Sbjct: 1325 KKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN--PKSKKEKKKSDKRKKDKEKKEKKK 1382
Query: 1239 MEDTLEHTDKE 1249
D E
Sbjct: 1383 KAKKASTKDSE 1393
Score = 39.7 bits (91), Expect = 0.026
Identities = 49/190 (25%), Positives = 78/190 (41%), Gaps = 21/190 (11%)
Query: 1593 ETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVN 1652
ETE+EG P A + + SA GQA S S+D S +S++T VEV+ S
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSA---------GQADSS-SEDTSSSSDET-DVEVKAS--- 217
Query: 1653 DQQLEEVVLPSEEEGGGAGTKSVPEDDGHA-LLAERIEKSLVEPKEDEKGDDVDDPENQN 1711
+++ +V S G G + P G A +A + + E + ++ D E +
Sbjct: 218 -EKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEET 276
Query: 1712 ---SALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQ 1768
AL ASG ++ + K+ ++ A GK KA + +E+ Q
Sbjct: 277 PAAKALLQAKASGKTSQVGAASAPAKESPRKGA--APAPPGKTGPAVAKAQAGKREEDSQ 334
Query: 1769 KQERESAKSE 1778
ES E
Sbjct: 335 SSSEESDSEE 344
Score = 35.4 bits (80), Expect = 0.50
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 216 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 274
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1286 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1345
Query: 275 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 334
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1346 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1389
Query: 335 VDTEEDGKAEVASEKLTASE 354
D+E + + +K TA +
Sbjct: 1390 KDSESPSQKKKKKKKKTAEQ 1409
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 101 bits (251), Expect = 7e-21
Identities = 294/1531 (19%), Positives = 551/1531 (35%), Gaps = 221/1531 (14%)
Query: 321 VEASEKKKEQEPEKVDTEEDGKA-EVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVEL 379
V A+ + KEQ +K + ++ + SE ++ E A L A+ +V
Sbjct: 24 VRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDA---ALQAKKTRVSD 80
Query: 380 PSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETA 439
P +S S+ EE+ A T ++ V+ S+++E+ + + + +T
Sbjct: 81 P----ISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTG 136
Query: 440 GSVP-------AEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKP 492
S+P L+ + + AEP+ + ET G P GA P +
Sbjct: 137 NSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPG---MVSA 193
Query: 493 PEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES--GEHTQV 550
+ S + SS + V+ +K+ + + KG G G + G+ V
Sbjct: 194 GQADSSSEDTSSSSDETDVEVKASEKILQV----RAASAPAKGTPGKGATPAPPGKAGAV 249
Query: 551 PADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGV 607
+ + + E+ ESS+ + EE T K L + + G+ + GA S K+ R+G
Sbjct: 250 ASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA 309
Query: 608 TPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 667
P K K E D + ++ S + ++ S +++ + P E
Sbjct: 310 APAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKE 368
Query: 668 EPKRKVDTSVSWE-----ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 722
P++ + + A + VG ++ +R S + + + GK +
Sbjct: 369 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 428
Query: 723 TGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSED 782
+ G G G P + G T V WE + S+S EE S+
Sbjct: 429 VKPASTM-GMGPLGKGAGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDS 478
Query: 783 SIAGSGVEHSTPDT-EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDS 841
S + P P +E+S +I + +P + P + AGP
Sbjct: 479 S------DGEVPTAVAPAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ---- 521
Query: 842 DVPAVVPLSEYDAVEREK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
V A P+ ++ E M A QA+ + + P+ KA + + + ++V
Sbjct: 522 -VKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVA 580
Query: 891 MMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTV 950
+ +A T SP+ S +V ++ +++ E +EEE +
Sbjct: 581 PVRVGTQAPRKAGTAT---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGL 631
Query: 951 TEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLT 1010
+ + + V A + + TA L + G T V A Q
Sbjct: 632 AVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ-- 682
Query: 1011 DSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPV 1069
+ +++EE + +E ++ ++TQ A + GT P V+
Sbjct: 683 EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAA 739
Query: 1070 QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTES 1129
+A+ P + + + V+ + A QT PE E + E
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEE 797
Query: 1130 IESSELVTTCQAETLAGVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQ 1187
+S E +AETLA VK + A+ P +S G+ P PG T
Sbjct: 798 SDSEE-----EAETLAQVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTG 843
Query: 1188 KDEIVEIHEENEVASGTQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE 1244
+++ +S +S G A AQ +PP +F + + + T
Sbjct: 844 PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPA 899
Query: 1245 HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVAL 1304
+ T +E T + E +P + L I T + +A
Sbjct: 900 QAQ---AASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP 956
Query: 1305 KG---------EGTEEAECKKDDALELQSHAKSPPS-PVEREMVVQVEREKTEAEPTHVN 1354
K E + ++ KK + Q K+P S P+ + + + ++ +EA+P
Sbjct: 957 KASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVAR 1016
Query: 1355 EEKLEH-ETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQ 1413
+ ++AV S Q AK + L P + ++A
Sbjct: 1017 TQPSSGVDSAVGTLPATSPQSTSVQ-------AKGTNKLRKPKLPEV--QQATKAPESSD 1067
Query: 1414 SSEASFTLTAAAEEEKVLGETANILETGETL---EPAGAHLVLEEKSSEKNEDFAAHPGE 1470
SE S ++ +EE+ GE ++ TL P+ ++EE ++E +ED P +
Sbjct: 1068 DSEDSSDSSSGSEED---GEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQ 1124
Query: 1471 DAVP-------TGPDCQA-KSTPVIVSA---TTKKGLSSDLEGEKTTSLKWKSDEVDEQV 1519
+ T + QA K+TP + S+ ++ D +G++ + + + +
Sbjct: 1125 SLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKT 1184
Query: 1520 ACQEVKVSVAIE-DLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT 1578
+E + +P+ G + + L NI Q + Q +E Q
Sbjct: 1185 GGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQ---------PWPLNEAQV 1235
Query: 1579 QAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMS--- 1635
QA V+K ++ QE +K + + S++ K + A S K +
Sbjct: 1236 QASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGE 1295
Query: 1636 --EAS---EKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA----GTKSVPEDDGHALLAE 1686
EAS EKT T +G D+ +V E++G G+ G K PE E
Sbjct: 1296 GGEASVSPEKTSTTS-KGKAKRDKASGDV---KEKKGKGSLGSQGAKDEPE--------E 1343
Query: 1687 RIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVEL 1746
++K + +G D +P+++ K+K+K D ++ +
Sbjct: 1344 ELQKGM----GTVEGGDQSNPKSK-----------------------KEKKKSDKRKKDK 1376
Query: 1747 QEGKVHSESDKAITPQAQEELQKQERESAKS 1777
++ + ++ KA T ++ QK++++ K+
Sbjct: 1377 EKKEKKKKAKKASTKDSESPSQKKKKKKKKT 1407
Score = 73.2 bits (178), Expect = 2e-12
Identities = 222/1146 (19%), Positives = 378/1146 (32%), Gaps = 229/1146 (19%)
Query: 238 KPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFK 297
K EE + +S P + ++ EE +EE E + K + A + +S + ++ S+ K
Sbjct: 64 KAEEDAALQAKKTRVSDPISTSESSEE-EEEAEAETAKATPRLASTNSSVLGADLPSSMK 122
Query: 298 -KFFTQGWAGWRKKTSFRKPKEDEVEAS-----EKKKEQEPEK-----VDTEEDGKAEV- 345
K + + S P + A+ +K EP +TEE+G
Sbjct: 123 EKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAF 182
Query: 346 ---ASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEE---QVSGSQGPSEEKPAPL 399
A + ++ QA S+ + S++ VE+ + E QV + P++ P
Sbjct: 183 GAAAKPGMVSAGQAD-----SSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKG 237
Query: 400 ATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEET-------------------AG 440
AT K + A E +EE EET A
Sbjct: 238 ATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA 297
Query: 441 SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL--SKPPEGVVS 498
S PA+E A P V + ED ++ S E+ P G
Sbjct: 298 SAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAP 357
Query: 499 EVEMLSS--QERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPD 556
+V S+ +E + +P T ++ KQ+ EES + A
Sbjct: 358 QVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 417
Query: 557 SQEEQKGESSASSPEEPEEITCLEKGLAEVQ-----------QDGEAEEGATSDGEKKRE 605
+Q + G+S P + L KG V Q G+ EE + S E+ +
Sbjct: 418 AQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSD 477
Query: 606 ---GVTPWA-------------SFKKMVTPKK-------------RVRRPSESDKEDELD 636
G P A K +P K + +P ++ + E
Sbjct: 478 SSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSE-- 535
Query: 637 KVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE-ALICVGSSKKRARRG 695
S + S E+ A+ + K +++ P+ + +K +T+ S + A + VG+ R
Sbjct: 536 -ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGT 594
Query: 696 SSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEG 755
++S P GG + P + SSS E++ S E G
Sbjct: 595 ATSPAGSSPAVAGGTQR------------------------PAEDSSSSEESDSEEEKTG 630
Query: 756 VSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRR 815
++ V K L+ K+ + T PG
Sbjct: 631 LAV------TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG---------------- 668
Query: 816 KKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 875
K P Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 669 KTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAK 726
Query: 876 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ----------- 924
+A AA ++RSPS + V P
Sbjct: 727 GT---------------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVP 771
Query: 925 -------VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE 974
A+A EE E E +EEE T+ + P + + ++ A+ +P
Sbjct: 772 SVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPR 831
Query: 975 ---AVTAAETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT- 1016
A T GP A+ G + S++EE+ A + +T + P+ +
Sbjct: 832 KGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSP 891
Query: 1017 --EEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT--------------- 1059
ATP Q P + R ++ ++ + + ++E +P T
Sbjct: 892 AGPAATPAQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 948
Query: 1060 GGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQG--KVVGQTTP 1117
+ A A +E + S KK+ +V + + P TQ KV+ Q
Sbjct: 949 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKAS 1008
Query: 1118 ESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPV 1177
E+ + S V T A S + QA + + P E +T
Sbjct: 1009 EAQPPVARTQPSSGVDSAVGTLPA------TSPQSTSVQAKGTNKLRKPKLPEVQQATKA 1062
Query: 1178 ADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQS 1237
+ D E+ E G +S T P++ E EET +S
Sbjct: 1063 PESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTE--------TLVEETAAES 1114
Query: 1238 KMEDTL 1243
+D +
Sbjct: 1115 SEDDVV 1120
Score = 60.8 bits (146), Expect = 1e-08
Identities = 252/1348 (18%), Positives = 466/1348 (34%), Gaps = 196/1348 (14%)
Query: 499 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 558
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 559 EEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEK--KREGVTPWASFKKM 616
EE++ E+ A + + + + +E A ++ EK K P + K
Sbjct: 89 EEEE-EAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 617 VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS 676
V + P KSA S+ + SE +EE GSV +
Sbjct: 148 VANLLSGKSPR-----------KSAEPSANTTLVSETEEE--GSVP----------AFGA 184
Query: 677 VSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 736
+ ++ G + + SSS +E + + A GT G G+
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPG--KGATPAP 242
Query: 737 PGQGSS--SPEQAGSPTEGEGVSTWESF-KRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
PG+ + S +AG P E S+ ES TP K+ + + + S G+
Sbjct: 243 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAA----- 297
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ P KE R+ P + P G E+DS S +
Sbjct: 298 --SAPAKESP----------RKGAAPAPPGKTGPAVAKAQAGKREEDSQ-------SSSE 338
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSW 913
+ E+ QA+ S + P+ +AA+ +KE AA A +
Sbjct: 339 ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK-----GAAPAPPRKTGP--------- 384
Query: 914 ISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTP 973
+A+ + +Q E + E +RE +A V +PL ++ + + + + L
Sbjct: 385 -AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV-KPLGKSPQVKPASTMGMGPL-- 440
Query: 974 EAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIE 1033
+ AGP+ + A+ + + + DS ++EE++ + E
Sbjct: 441 -----GKGAGPVPPGKVGPATPSAQVGKWEE------DSESSSEESSDSSDGEVPTAVAP 489
Query: 1034 EQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVV 1093
QE+ +LQA + + P G P+ + +AE+P + +E+S ++ +D
Sbjct: 490 AQEKSLGNILQA------KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESS--EESSDSA 541
Query: 1094 LKVDAQEAKTEPFTQGKV-VGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEM 1152
+A A T + + + QT ++ K T S + + + QA AG +
Sbjct: 542 DSEEAPAAMTAAQAKPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 599
Query: 1153 VMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1212
A+ + P + + ++ + G V + + V G Q +A
Sbjct: 600 GSSPAVA-GGTQRPAEDSSSSEESDSEEEKTGLA-----VTVGQAKSVGKGLQ---VKAA 650
Query: 1213 AVPA-----QKERPPAPSSF---VFQEETKEQSKMEDTLEHTD-KEVSVETVSILSKTEG 1263
+VP Q P P V Q + ++Q E + E +D +E + + + +
Sbjct: 651 SVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKK 710
Query: 1264 TQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKV-TEVALKGEGTEEAECKKDDALEL 1322
TQ A + G + T ++++ ++V + + +
Sbjct: 711 TQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV 770
Query: 1323 QSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPI 1382
S K+ + + + + + +E E ++ + E ET V ++ P
Sbjct: 771 PSVGKAVATAAQAQTGPEEDSGSSEEE----SDSEEEAETLAQVKPSGKTHQIRAALAPA 826
Query: 1383 IDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSS---------EASFTLTAAAE-EEKVLG 1432
+ ++ ++ +PP G A K S EA +T+A + ++
Sbjct: 827 KESPRKGAA--PTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIF 884
Query: 1433 ETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPG-----EDAVP----------TGP 1477
N G PA A + + +E A ED +P T
Sbjct: 885 VDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 944
Query: 1478 DCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPEN 1537
+ P I + G SS E + + K + E A Q K + A L +
Sbjct: 945 VTMPTAHPRIAPKASMAGASSSKESSRISDGKKQ-----EGPATQVSKKNPASLPLT-QA 998
Query: 1538 GILELETKSSKLVQNIIQT----AVDQFVRTEETATEMLTS------------ELQTQAH 1581
+ L K+S+ + +T VD V T + TS +L
Sbjct: 999 ALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQ 1058
Query: 1582 VIKA--------DSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKD 1633
KA DS D+ +E++GE PQ + T + +E T V + ++ S+D
Sbjct: 1059 ATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTE-TLVEETAAESSED 1117
Query: 1634 MSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLV 1693
A +++ L + P +K+ P+ D ++ S +
Sbjct: 1118 DVVAPSQSL-------------LSGYMTPGLTPANSQASKATPKLDSSPSVS-----STL 1159
Query: 1694 EPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHS 1753
K+D G P+ L + +GG S T +K K+ A + + S
Sbjct: 1160 AAKDDPDGKQEAKPQQAAGML--SPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS 1217
Query: 1754 ESDKAITPQAQEELQKQERESAKSELTE 1781
+ + Q + Q + S LTE
Sbjct: 1218 NITQCLLGQPWPLNEAQVQASVVKVLTE 1245
Score = 60.5 bits (145), Expect = 1e-08
Identities = 269/1389 (19%), Positives = 476/1389 (34%), Gaps = 230/1389 (16%)
Query: 3 AGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPAT--------- 53
A + T + +P SS PS A+A + + PAT
Sbjct: 94 AEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLS 153
Query: 54 -KLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDS 112
K +K+ + S + + E +EG + GA G +++ + + D
Sbjct: 154 GKSPRKSAEPSANTTLVSETE---EEGSVPAF-GAAAKPGMVSAGQADSSSEDTSSSSDE 209
Query: 113 EDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPS--SESNLEELTQPTESQANDI 170
DV + S+K + ++A G+ TP + + S++ + + +ES + +
Sbjct: 210 TDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEE- 268
Query: 171 GFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKES 230
D E+ + L K G K +GA A +KES
Sbjct: 269 ---------------SSDSEEETPAAKALLQAKASG---------KTSQVGAASAPAKES 304
Query: 231 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 290
K + P + A+ E Q+ E + +E+ P+++ S +P
Sbjct: 305 PRKGAAPAPPGKTGPAVAKAQAGKREEDSQS----SSEESDSEEEAPAQAKPSGKAPQVR 360
Query: 291 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKL 350
+ K+ +G A + + + +V E+ E+ D++ + A + + ++
Sbjct: 361 AASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQV 420
Query: 351 TASEQAHPQEPAE---------------------SAHEPRLSAEYEKVELPSEEQVSGSQ 389
++ +PA + ++ E E SEE S
Sbjct: 421 KPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSD 480
Query: 390 GPSEEKPAPLATEVFDEKIEVHQEEVVAE--------VHVSTVEERTEEQKTEVEETAGS 441
G AP + ++ A+ V V E+ + EE++ S
Sbjct: 481 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 540
Query: 442 VPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP-------DEKV------ 488
+EE Q A+PA ++ + K C + T A ++P K
Sbjct: 541 ADSEEAPAAMTAAQ-AKPALKIPQTK-ACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 598
Query: 489 ----------LSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLK-KLSGKKQKGKR 537
+P E S E S +E+ + + + GL+ K + KG
Sbjct: 599 AGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSL 658
Query: 538 GGG------DEESGEHTQVPA----DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQ 587
G G + TQV A DS S+EE E +A+SP + + T ++K A+
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK--TSVKKTQAKAN 716
Query: 588 QDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKR--VRRPSESDKEDELDKVKSATLSS 645
A + VT A K+ K + VR P S ++
Sbjct: 717 PAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLAR-GPASVPSVGK 775
Query: 646 TESTASEMQ---EEMKGSVEEPKPEEPKRKVDTSV-----SWEALICVGSSKKRARRGSS 697
+TA++ Q EE GS EE E + + V + + + +K+ R+G++
Sbjct: 776 AVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAA 835
Query: 698 SDEEG--GPKAMGGDHQKADEAGKDKETGTDGILAGSQEH-----------DPGQGSSSP 744
G GP A Q D +E+ +DG + DP + + P
Sbjct: 836 PTPPGKTGPSAAQAGKQD-DSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGP 894
Query: 745 EQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESW 804
A +P + + ST + + + S S +SED + TP
Sbjct: 895 --AATPAQAQAASTPRKARASESTARSSSS----ESEDEDVIPATQCLTPGIRTNVVTMP 948
Query: 805 VSIKKFIPGRRKKRPDGKQEQAPVEDA----GPTGANEDDSDVPAVVPLSEYDAVEREKM 860
+ + P +E + + D GP A + PA +PL+
Sbjct: 949 TAHPRIAPKASMAGASSSKESSRISDGKKQEGP--ATQVSKKNPASLPLT---------- 996
Query: 861 EAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTE 920
Q A K Q +A V++ S V + + +T ++ + + +
Sbjct: 997 --QAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLP 1054
Query: 921 PLEQV--EAEAALLTEEVLEREVIAEEE---------PPTVTEPLPENREARGDTVVSE- 968
++Q E++ +E+ + +EE+ T+ P P +R +T+V E
Sbjct: 1055 EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTP----SRTETLVEET 1110
Query: 969 -AELTPEAVTAAE--------TAGPLGA-EEGTEASAAEETTEMVSAVSQLTDSPDTTEE 1018
AE + + V A T G A + ++A+ +++ VS+ D PD +E
Sbjct: 1111 AAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQE 1170
Query: 1019 ATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE--------DVLQPVQ 1070
A P Q P +E + Q K G G P+ ++ Q +
Sbjct: 1171 AKPQQAAGMLSPKTGGKEAASGTTPQ------KSRKPKKGAGNPQASTLALQSNITQCLL 1224
Query: 1071 RAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESI 1130
E Q +AS +K T+++ QE K KVV TT ES K + +
Sbjct: 1225 GQPWPLNEAQVQASVVKVLTELL----EQERK-------KVV-DTTKESSRKGWESRKRK 1272
Query: 1131 ESSELVTTCQAETLAGVKSQEMVM----EQAIPPDSVETPTDSETDGSTPVADFDAPGTT 1186
S + A T K +++ E ++ P+ +T T S+ A D
Sbjct: 1273 LSGDQPA---ARTPRSKKKKKLGAGEGGEASVSPE--KTSTTSKGKAKRDKASGDVKEKK 1327
Query: 1187 QKDEI------VEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKME 1240
K + E EE + GT GG ++ P K+ +E KE+ K
Sbjct: 1328 GKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN--PKSKKEKKKSDKRKKDKEKKEKKKKA 1385
Query: 1241 DTLEHTDKE 1249
D E
Sbjct: 1386 KKASTKDSE 1394
Score = 35.4 bits (80), Expect = 0.50
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 216 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 274
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1287 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1346
Query: 275 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 334
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1347 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1390
Query: 335 VDTEEDGKAEVASEKLTASE 354
D+E + + +K TA +
Sbjct: 1391 KDSESPSQKKKKKKKKTAEQ 1410
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 98.2 bits (243), Expect = 6e-20
Identities = 308/1574 (19%), Positives = 558/1574 (35%), Gaps = 246/1574 (15%)
Query: 307 WRKKTSF-RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESA 365
W++ + RK K +E A + KK + + + T E + E +E TA +A P+ S
Sbjct: 53 WQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETA--KATPR--LAST 108
Query: 366 HEPRLSAEYE---KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 422
+ L A+ K + +E + +G G S PA T + ++ + +
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 423 TVEERTEE------------------QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV 464
V E EE Q E S E VE + A+ V
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 465 KLKETCVSGEDPTQG--ADLSPDEKVLSKPP---------------EGVVSEVEM-LSSQ 506
KE+ P G D++P K + PP EG SE E ++
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
Query: 507 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 566
++K L+ S K GK G G+ V + + + E+ ESS
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGK------GATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 567 ASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGVTPWASFKKMVTPKKRV 623
+ + EE T K L + + G+ + GA S K+ R+G P K K
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402
Query: 624 RRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE--- 680
E D + ++ S + ++ S +++ + P E P++ + +
Sbjct: 403 AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKESPRKGAAPAPPRKTGP 461
Query: 681 --ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPG 738
A + VG ++ +R S + + + GK + + G G
Sbjct: 462 AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM-GMGPLGKG 520
Query: 739 QGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT-E 797
G P + G T V WE + S+S EE S+ S + P
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDSS------DGEVPTAVA 565
Query: 798 PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVER 857
P +E+S +I + +P + P + AGP V A P+ ++ E
Sbjct: 566 PAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ-----VKAEKPMDNSESSEE 613
Query: 858 EK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATII 906
M A QA+ + + P+ KA + + + ++V + +A T
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 907 EERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 966
SP+ S +V ++ +++ E +EEE + + + + V
Sbjct: 674 ---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 967 SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 1026
A + + TA L + G T V A Q + +++EE + +E
Sbjct: 725 KAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ--EDSESSEEESDSEEAA 775
Query: 1027 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPVQRAEAERPEEQAEASG 1085
++ ++TQ A + GT P V+ +A+ P +
Sbjct: 776 ASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 1086 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLA 1145
+ + V+ + A QT PE E + E +S E +AETLA
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEESDSEE-----EAETLA 885
Query: 1146 GVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1203
VK + A+ P +S G+ P PG T +++ +S
Sbjct: 886 QVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTGPSAAQAGKQDDSGSSS 936
Query: 1204 TQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+S G A AQ +PP +F + + + T + T
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPAQAQ---AASTPRKARA 989
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKG---------EGTEE 1311
+E T + E +P + L I T + +A K E +
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 1312 AECKKDDALELQSHAKSPPS-PVEREMVVQVEREKTEAEPTHVNEEKLEH-ETAVTVSEE 1369
++ KK + Q K+P S P+ + + + ++ +EA+P + ++AV
Sbjct: 1050 SDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPA 1109
Query: 1370 VSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEK 1429
S Q AK + L P + ++A SE S ++ +EE+
Sbjct: 1110 TSPQSTSVQ-------AKGTNKLRKPKLPEV--QQATKAPESSDDSEDSSDSSSGSEED- 1159
Query: 1430 VLGETANILETGETL--EPAGAHLVLEEKSSEKNEDFAAHPGEDAVP-------TGPDCQ 1480
GE ++ TL P+ ++EE ++E +ED P + + T + Q
Sbjct: 1160 --GEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQ 1217
Query: 1481 A-KSTPVIVSA---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE-DLEP 1535
A K+TP + S+ ++ D +G++ + + + + +E + +P
Sbjct: 1218 ASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKP 1277
Query: 1536 ENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETE 1595
+ G + + L NI Q + Q +E Q QA V+K ++ QE +
Sbjct: 1278 KKGAGNPQASTLALQSNITQCLLGQ---------PWPLNEAQVQASVVKVLTELLEQERK 1328
Query: 1596 KEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMS-----EAS---EKTMTVEVE 1647
K + + S++ K + A S K + EAS EKT T +
Sbjct: 1329 KVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTS-K 1387
Query: 1648 GSTVNDQQLEEVVLPSEEEGGGA----GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDD 1703
G D+ +V E++G G+ G K PE E ++K + +G D
Sbjct: 1388 GKAKRDKASGDV---KEKKGKGSLGSQGAKDEPE--------EELQKGM----GTVEGGD 1432
Query: 1704 VDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQA 1763
+P+++ K+K+K D ++ + ++ + ++ KA T +
Sbjct: 1433 QSNPKSK-----------------------KEKKKSDKRKKDKEKKEKKKKAKKASTKDS 1469
Query: 1764 QEELQKQERESAKS 1777
+ QK++++ K+
Sbjct: 1470 ESPSQKKKKKKKKT 1483
Score = 63.9 bits (154), Expect = 1e-09
Identities = 252/1309 (19%), Positives = 440/1309 (33%), Gaps = 185/1309 (14%)
Query: 499 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 558
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 559 EEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEK--KREGVTPWASFKKM 616
EE++ E+ A + + + + +E A ++ EK K P + K
Sbjct: 89 EEEE-EAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKT 147
Query: 617 VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTS 676
V + P KSA S+ + SE +EE GSV +
Sbjct: 148 VANLLSGKSPR-----------KSAEPSANTTLVSETEEE--GSV----------PAFGA 184
Query: 677 VSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 736
+ ++ G + + SSS +E D GK + +
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDE------------TDVEGK------PSVKPAQVKAS 226
Query: 737 PGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT 796
SP + +P G+ K P K K EE+SE S GS E P
Sbjct: 227 SVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP-- 284
Query: 797 EPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVE 856
G + +K + R P A P A S A P + ++
Sbjct: 285 -AGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSS 343
Query: 857 REKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISA 916
E ++++ E P KA + SQV +A + R P
Sbjct: 344 EESSDSEE-----ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGA--APAPPGKTGP 396
Query: 917 SVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEP---LPENREARGDTVVS----EA 969
+V + E + + E E +EEE P +P P+ R A S A
Sbjct: 397 AVAKAQAGKREEDSQSSSE----ESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA 452
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
P A +G +E S++EE+ A++ + + P+ G
Sbjct: 453 PAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM-----NAAQVKPL----GKS 503
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKE 1089
P ++ L A V PG GP V + E E E +E S +
Sbjct: 504 PQVKPASTMGMGPLGKGAGPVP-----PGKVGPATPSAQVGKWE-EDSESSSEESSDSSD 557
Query: 1090 TDVVLKV-DAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQA--ETLAG 1146
+V V AQE Q K +KA V +++ + + ++ E+
Sbjct: 558 GEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDS 617
Query: 1147 VKSQE----MVMEQAIP----PDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEEN 1198
S+E M QA P P + P + T S VA V
Sbjct: 618 ADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVR----------VGTQAPR 667
Query: 1199 EVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSIL 1258
+ + T G+ + AV +RP SS + E+S E+ E T V+V +
Sbjct: 668 KAGTATSPAGS-SPAVAGGTQRPAEDSS------SSEESDSEE--EKTGLAVTVGQAKSV 718
Query: 1259 SKTEGTQEADQYADEKTKDVPFFEGLEGSIDTG---ITVSREKVTEVALKGEGTEEAECK 1315
K G Q K VP ++GS+ G + + T +K E E++E
Sbjct: 719 GK--GLQ-------VKAASVP----VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESS 765
Query: 1316 KDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETA-----VTVSEEV 1370
++++ + + A SP ++ V++ + +A P + + VT + +
Sbjct: 766 EEES-DSEEAAASP-----AQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQA 819
Query: 1371 SKQLLQTVNVPIIDGAKEVSSLEG-SPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEK 1429
++ V P+ + G + P +G+ A + Q E S + ++ E+
Sbjct: 820 KQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEE 879
Query: 1430 VLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVS 1489
A + +G+T + A +E P + A PT P K+ P
Sbjct: 880 EAETLAQVKPSGKTHQIRAALAPAKES-----------PRKGAAPTPP---GKTGPSAAQ 925
Query: 1490 A-----TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A + SD +GE ++ + + + + S A P
Sbjct: 926 AGKQDDSGSSSEESDSDGEAPAAVT-SAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
Query: 1545 KSSKLVQNIIQTAVDQFVRTEE-TATEMLTSELQTQ------AHV-IKADSQDAGQETEK 1596
+ ++ ++ +++ + + AT+ LT ++T AH I + AG + K
Sbjct: 985 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK 1044
Query: 1597 EGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQL 1656
E + E P T +++ + S +++A+ K + + + Q
Sbjct: 1045 ESSRISDGKKQEGPATQVSKKNPA----------SLPLTQAALKVLAQKASEA----QPP 1090
Query: 1657 EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALAD 1716
PS GT ++ A+ K L +PK E PE+ + +
Sbjct: 1091 VARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNK-LRKPKLPEVQQATKAPESSDDSEDS 1149
Query: 1717 TDASGGLTKESPDTNGPKQKE----KEDAQEVELQEGKVHSESDKAITP 1761
+D+S G ++ G K E ++E S D + P
Sbjct: 1150 SDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAP 1198
Score = 60.1 bits (144), Expect = 2e-08
Identities = 279/1405 (19%), Positives = 483/1405 (34%), Gaps = 247/1405 (17%)
Query: 5 SSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAP----------DTTADPAIAASD---- 50
S R +P ++ +E E G P+ AA D++++ ++SD
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDV 212
Query: 51 ---PATKLLQ-KNGQLSTINGVAEQDELSLQE-GDLNGQ-KGALNGQGALNSQEEEEVIV 104
P+ K Q K +ST A + + + GD+ Q KG + EEE
Sbjct: 213 EGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESES 272
Query: 105 TEVGQRDSED--------VSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNL 156
+E G E+ V + ++ SA G P +S++
Sbjct: 273 SEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKA 332
Query: 157 EELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHK 216
+ + +ES + + D E+ + L K G K
Sbjct: 333 GKPEEDSESSSEE----------------SSDSEEETPAAKALLQAKASG---------K 367
Query: 217 DPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKE 276
+GA A +KES K + P + A+ E Q+ E + +E+
Sbjct: 368 TSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQS----SSEESDSEEEA 423
Query: 277 PSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVD 336
P+++ S +P + K+ +G A + + + +V E+ E+ D
Sbjct: 424 PAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESD 483
Query: 337 TEEDGKAEVASEKLTASEQAHPQEPAE---------------------SAHEPRLSAEYE 375
++ + A + + ++ ++ +PA + ++ E
Sbjct: 484 SDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEE 543
Query: 376 KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAE--------VHVSTVEER 427
E SEE S G AP + ++ A+ V V E+
Sbjct: 544 DSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK 603
Query: 428 TEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP--- 484
+ EE++ S +EE Q A+PA ++ + K C + T A ++P
Sbjct: 604 PMDNSESSEESSDSADSEEAPAAMTAAQ-AKPALKIPQTK-ACPKKTNTTASAKVAPVRV 661
Query: 485 ----DEKV----------------LSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTG 524
K +P E S E S +E+ + + + G
Sbjct: 662 GTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKG 721
Query: 525 LK-KLSGKKQKGKRGGG------DEESGEHTQVPA----DSPDSQEEQKGESSASSPEEP 573
L+ K + KG G G + TQV A DS S+EE E +A+SP +
Sbjct: 722 LQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQV 781
Query: 574 EEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKR--VRRPSESDK 631
+ T ++K A+ A + VT A K+ K + VR P S
Sbjct: 782 K--TSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTV 839
Query: 632 EDELDKVKSATLSSTESTASEMQ---EEMKGSVEEPKPEEPKRKVDTSV-----SWEALI 683
++ +TA++ Q EE GS EE E + + V + +
Sbjct: 840 LAR-GPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRA 898
Query: 684 CVGSSKKRARRGSSSDEEG--GPKAMGGDHQKADEAGKDKETGTDGILAGSQEH------ 735
+ +K+ R+G++ G GP A Q D +E+ +DG +
Sbjct: 899 ALAPAKESPRKGAAPTPPGKTGPSAAQAGKQD-DSGSSSEESDSDGEAPAAVTSAQVIKP 957
Query: 736 -----DPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVE 790
DP + + P A +P + + S TPRK S E + S + S E
Sbjct: 958 PLIFVDPNRSPAGP--AATPAQAQAAS---------TPRKARAS--ESTARSSSSESEDE 1004
Query: 791 HSTPDTE---PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVV 847
P T+ PG + V++ P AP ++++ S +
Sbjct: 1005 DVIPATQCLTPGIRTNVVTM-----------PTAHPRIAPKASMAGASSSKESSRIS--- 1050
Query: 848 PLSEYDAVEREKMEAQQAQKS-AEQPEQKAATEV-SKELSESQVHMMAAAVADGTRAAT- 904
D ++E Q ++K+ A P +AA +V +++ SE+Q + + G +A
Sbjct: 1051 -----DGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVG 1105
Query: 905 IIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDT 964
+ SP S V+A+ L + + E + T ++ E D+
Sbjct: 1106 TLPATSPQSTS---------VQAKGT----NKLRKPKLPEVQQATKAPESSDDSEDSSDS 1152
Query: 965 VVSEAE--LTPEAVTAAETAGPLGAEEGT--EASAAEETTEMVSAVSQLTDSPDTTEEAT 1020
E P+ +A T GP + T E +AAE + + V A SQ S T T
Sbjct: 1153 SSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLT 1212
Query: 1021 PV-QEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQ--------LPGTGGPEDV--LQPV 1069
P + P ++ + + K+E++ P TGG E P
Sbjct: 1213 PANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQ 1272
Query: 1070 QRAEAERPEEQAEASGLKKETDVV------------LKVDAQEAK--TEPFTQ-GKVVGQ 1114
+ + ++ +AS L ++++ +V A K TE Q K V
Sbjct: 1273 KSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVD 1332
Query: 1115 TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVM----EQAIPPDSVETPTDSE 1170
TT ES K + + S + A T K +++ E ++ P+ +T T S+
Sbjct: 1333 TTKESSRKGWESRKRKLSGDQPA---ARTPRSKKKKKLGAGEGGEASVSPE--KTSTTSK 1387
Query: 1171 TDGSTPVADFDAPGTTQKDEI------VEIHEENEVASGTQSGGTEAEAVPAQKERPPAP 1224
A D K + E EE + GT GG ++ P K+
Sbjct: 1388 GKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSN--PKSKKEKKKS 1445
Query: 1225 SSFVFQEETKEQSKMEDTLEHTDKE 1249
+E KE+ K D E
Sbjct: 1446 DKRKKDKEKKEKKKKAKKASTKDSE 1470
Score = 35.4 bits (80), Expect = 0.50
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 216 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 274
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1363 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1422
Query: 275 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 334
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1423 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1466
Query: 335 VDTEEDGKAEVASEKLTASE 354
D+E + + +K TA +
Sbjct: 1467 KDSESPSQKKKKKKKKTAEQ 1486
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 93.6 bits (231), Expect = 2e-18
Identities = 267/1269 (21%), Positives = 450/1269 (35%), Gaps = 142/1269 (11%)
Query: 233 KQSTEKPEETLKR-EQSHAEISPPAESGQAVEECKEEGEEKQEK--EPSKSAESPTSPVT 289
K EK E+T +R E+ +++ E + + K QE+ E A V
Sbjct: 9183 KPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVI 9242
Query: 290 SETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDT--EEDGKAEVAS 347
SE F + + + E+++ + K+ + P KV E+ EVA
Sbjct: 9243 SEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEKPAPEEVAP 9302
Query: 348 EKLTASEQAH-------PQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLA 400
+ + P++P +P + E P +V P E+ P P+A
Sbjct: 9303 VPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVA 9362
Query: 401 T--EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAE 458
E K+ Q+ VV E ++ V +R E V E EE + + +E
Sbjct: 9363 KKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVP 9422
Query: 459 PAKELVKLKETCVSGED---PTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSP 515
P ++ L + V E P A +P PP VS+ ++ +E+ V
Sbjct: 9423 PPPKVPALPKKPVPEEKVAVPVPVAKKAP-------PPRAEVSKKTVV--EEKRFVAEEK 9473
Query: 516 LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEE 575
L + + +EE G V + +EE+ + EEPEE
Sbjct: 9474 LSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEE 9533
Query: 576 ITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDEL 635
EK L + + EAE ++ ++K+ + P K P +V E+ K+
Sbjct: 9534 YVVEEK-LHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKV---PEAPKKIVP 9589
Query: 636 DKVKSATLSSTESTASEMQEEMKGSVEEPK-PEEPKRKVDTSVSWEALICVGSSKKRARR 694
+K A + E V PK PEEPK+ V +K+
Sbjct: 9590 EKKVPAPVPKKEK------------VPPPKVPEEPKKPVP--------------EKKVPP 9623
Query: 695 GSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGE 754
EE P + H + + K +L + + +P +A P E +
Sbjct: 9624 KVIKMEEPLPAKVTERHMQITQEEK--------VLVAVTKKE------APPKARVPEEPK 9669
Query: 755 GVSTWESFKRLVTPRKKSK-SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPG 813
E +L R++ +K+ E + + V P EP IK+
Sbjct: 9670 RAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQP------IKEVTIM 9723
Query: 814 RRKKRPDGKQEQAPV---EDAGPTGANEDDSDVPAVVPLSEYDAVER-EKMEAQQAQKSA 869
K+R +E+A E+ D + P EYD E E+ E ++ ++
Sbjct: 9724 EEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHE 9783
Query: 870 EQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEA 929
E + K + E V A + EE+ P I + P +V E
Sbjct: 9784 EYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEP 9843
Query: 930 ALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEE 989
+ EE + R I + E VTEP ++ + P+ V A E E
Sbjct: 9844 KKVFEEKI-RISITKREKEQVTEP------------AAKVPMKPKRVVAEEKVPVPRKEV 9890
Query: 990 GTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK 1049
E E+ + T E V+E E + + EE+ +EV+ + K
Sbjct: 9891 APPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHE-EEEFITEEEVVPVIPVK 9949
Query: 1050 VKEESQLPGTGGPEDVLQPVQRAEA--------ERPEEQAEASGLKKETDVVLKVDAQEA 1101
V E + P + V P ++ ++PEE+ KKE KV E
Sbjct: 9950 VPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVP--EV 10007
Query: 1102 KTEPFTQGKVVGQTTPESFE----KAPQVTES-IESSELVTTCQAETLAGVKSQEMVMEQ 1156
+P + KV P+ E K P+V + + ++ + A V ++
Sbjct: 10008 PKKPVPEEKVP-VPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKK 10066
Query: 1157 AIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEI-VEIHEENEVASGTQSGGTEAEAVP 1215
IP + TP + + P P + + V + +E EV E E VP
Sbjct: 10067 LIPEEKKPTPVPKKVEAPPP----KVPKKREPVPVPVALPQEEEVLF-------EEEIVP 10115
Query: 1216 AQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKT 1275
++ P E +E E+ + ++EV E I + E ++Y E+
Sbjct: 10116 EEEVLP----------EEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEE 10165
Query: 1276 KDVPFFEGL-----EGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPP 1330
+ VP E L + + + ++KVTE + EEA K + + K
Sbjct: 10166 EFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRII 10225
Query: 1331 SPVEREMVVQVEREKTEAEPTHVNEEKLEHET-AVTVSEEVSKQLLQTVNVPIIDGAKEV 1389
P E E++ E+ E EP ++EE++ E ++ EEV+ + V + A
Sbjct: 10226 LPKEEEVLPVEVTEEPEEEP--ISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTP 10283
Query: 1390 SSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGA 1449
+ PP ++ K+ V + E K + E ++ E + PA
Sbjct: 10284 VPKKVEAPPAKVSKKIPEEKVPVPVQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKG 10343
Query: 1450 HLVLEEKSS 1458
VLEEK S
Sbjct: 10344 RTVLEEKVS 10352
Score = 89.7 bits (221), Expect = 2e-17
Identities = 295/1525 (19%), Positives = 547/1525 (35%), Gaps = 212/1525 (13%)
Query: 217 DPSLGAGEAASKESEPKQSTEKPEETL--KREQSHAEISPPAESGQA------VEECKEE 268
D S A E K+ +K +E + K++ H E ES + VE E
Sbjct: 9029 DVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEP 9088
Query: 269 GEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKK 328
E+ +EP + E E +++ F +G + ++ + + +E+ EA ++++
Sbjct: 9089 FEQPYYEEPDEDYEEIKVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQERE 9148
Query: 329 EQEPEKVDTEEDGK----AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQ 384
+ +K EE + A+V +K + + E + E EKV++ +
Sbjct: 9149 VIQVQKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPE 9208
Query: 385 VSGSQGPSEEKPAPLATEVFDEKIE-VHQEE-VVAEVHVSTVEERTEEQKTEVEETAGSV 442
VS P + P+ EV + K+ VH ++ V++E + EE V E +
Sbjct: 9209 VSKKIVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEI 9268
Query: 443 PAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEM 502
EE + + A + EP ++ +L E P + A + +KV +PP V EV
Sbjct: 9269 VTEEKIHV-AISKRVEPPPKVPELPEKPA----PEEVAPVPIPKKV--EPPAPKVPEVPK 9321
Query: 503 LSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQK 562
E K P K+ + ++ K VP + +K
Sbjct: 9322 KPVPEEKKPVPVPKKEPAAPPKVPEVPKKP-----------------VPEEKIPVPVAKK 9364
Query: 563 GESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKR--EGVTPWASFKKMVTPK 620
E+ + E ++ E+ + V Q E+ A + KK+ E P ++ V P
Sbjct: 9365 KEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPP 9424
Query: 621 KRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE 680
+V P+ K +KV + + + E K +V E K + K+ +V
Sbjct: 9425 PKV--PALPKKPVPEEKV-AVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQR 9481
Query: 681 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQG 740
+ S +EEG ++ + ++ +E ++ E ++ +E+ +
Sbjct: 9482 VEVTRHEVSAEEEWSYSEEEEGVSISVYREEEREEE--EEAEVTEYEVMEEPEEYVVEE- 9538
Query: 741 SSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGK 800
E E E ++ + + K +K+EE + P+
Sbjct: 9539 --KLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKV---------PEAP--- 9584
Query: 801 EESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKM 860
KK +P ++ P K+E+ P P VP V +K+
Sbjct: 9585 -------KKIVPEKKVPAPVPKKEKVP----------------PPKVPEEPKKPVPEKKV 9621
Query: 861 EAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTE 920
+ + E+P TE ++++ + ++A + A + EE + V +
Sbjct: 9622 PPKVIKM--EEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLK 9679
Query: 921 PLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAE 980
+ E E E +R + +EE ++ P E + + T++ E E A T E
Sbjct: 9680 LKPKREEEPPAKVTEFRKR--VVKEEKVSIEAPKREPQPIKEVTIMEEKE---RAYTLEE 9734
Query: 981 TAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQ 1040
A + EE E + E EE P +E + EE E R
Sbjct: 9735 EAVSVQREEEYEEYEEYDYKEF--------------EEYEPTEEYD----QYEEYEEREY 9776
Query: 1041 EVLQAVAEKVKE-ESQLPGTGGPEDVLQPVQRAEAER------PEEQAEASGLKKETDVV 1093
E + E + E E +P PE+ + +A + PEE+ KK
Sbjct: 9777 ERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKK----- 9831
Query: 1094 LKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMV 1153
LK + EP + FE+ +++ + E VT A+ +K + +V
Sbjct: 9832 LKPPPPKVPEEP-----------KKVFEEKIRISITKREKEQVTEPAAKV--PMKPKRVV 9878
Query: 1154 MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEA 1213
E+ +P E + PV + P + +E+ E EV + +
Sbjct: 9879 AEEKVPVPRKEV--------APPVRVPEVPKELEPEEVAF---EEEVVTHVEE------- 9920
Query: 1214 VPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADE 1273
++ +EE E+ + ++ ++ E V + + + + E
Sbjct: 9921 -------------YLVEEE-------EEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPE 9960
Query: 1274 KTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPV 1333
+ K VP + E KV EV K E K + + P PV
Sbjct: 9961 EKKPVPVPKKKEAP--------PAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPV 10012
Query: 1334 EREMVVQVEREKTEAEPTHVNEEKL----EHETAVTVSEEVSKQLLQTVNVP--IIDGAK 1387
E V +K EA P V E E + V ++V + VP +I K
Sbjct: 10013 PEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEK 10072
Query: 1388 EVS----SLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGET 1443
+ + +E PP + E V + + E EE+VL E +L E
Sbjct: 10073 KPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEE 10132
Query: 1444 LEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLE-- 1501
+ P ++ EE+ E+ P E+ VP + V+ K + + +
Sbjct: 10133 VLPEEEEVLPEEEEIPPEEE-EVPPEEEYVPEEEEF-VPEEEVLPEVKPKVPVPAPVPEI 10190
Query: 1502 GEKTTSLKWKSDEVDEQVACQEVKVSVAIED----LEPENGILELETKSSKLVQNIIQTA 1557
+K T K + +E + +V +E+ L E +L +E + I +
Sbjct: 10191 KKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEE 10250
Query: 1558 VDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASA-----QDETPIT 1612
+ + + E E+ + VIK +A K+ E P A +++ P+
Sbjct: 10251 IPEEPPSIEEVEEVAPPRV---PEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVP 10307
Query: 1613 SAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQL-----EEVVLPS--EE 1665
K+E+ V + + + +K +G TV ++++ +EVV+ E
Sbjct: 10308 VQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLEL 10367
Query: 1666 EGGGAGTKSVPEDDGHALLAERIEK 1690
E A + +PE++ + E E+
Sbjct: 10368 EVVEAEVEEIPEEEEFHEVEEYFEE 10392
Score = 81.3 bits (199), Expect = 8e-15
Identities = 278/1240 (22%), Positives = 436/1240 (35%), Gaps = 157/1240 (12%)
Query: 228 KESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEK------EPSKSA 281
+E+ Q E+ EE + + E P E EE +E E+ E+ EP K
Sbjct: 9734 EEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPI 9793
Query: 282 ESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDG 341
P PV E T K A K P+E KK + P KV E
Sbjct: 9794 --PVKPVPEEPVPTKPK------APPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPK- 9844
Query: 342 KAEVASEKL----TASEQAHPQEPAESAH-EPRLSAEYEKVELPSEEQVSGSQGPSEEKP 396
+V EK+ T E+ EPA +P+ EKV +P +E + P K
Sbjct: 9845 --KVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKE 9902
Query: 397 APLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQE 456
F+E++ H EE + E + E EE+ EE +P ++ E+ +P
Sbjct: 9903 LEPEEVAFEEEVVTHVEEYLVEEEEEYIHE--EEEFITEEEVVPVIPV-KVPEVPRKPVP 9959
Query: 457 AEPAKELVKLKETCVSGEDPTQGADLSPDEKV------LSKPPEGVVSEVEMLSSQERMK 510
E V K+ + P P+EKV KPP V EV E
Sbjct: 9960 EEKKPVPVPKKKEAPPAKVPE--VPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKV 10017
Query: 511 VQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSP 570
P K + ++ K K+ VP +P E A P
Sbjct: 10018 PVPVPKKVEAPPAKVPEVPKKPVPEKK------------VPVPAPKKVE----APPAKVP 10061
Query: 571 EEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGV-TPWA-------SFKKMVTPKKR 622
E P+++ EK V + EA KKRE V P A F++ + P++
Sbjct: 10062 EVPKKLIPEEKKPTPVPKKVEAPPPKV---PKKREPVPVPVALPQEEEVLFEEEIVPEEE 10118
Query: 623 VRRPSES--DKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEE--PKRKVDTSVS 678
V E +E+E+ + L E E +E P+ EE P+ +V V
Sbjct: 10119 VLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVLPEVK 10178
Query: 679 WEALI--CVGSSKKRARRGS---SSDEEGGPKAMGGDHQKADEAG---KDKETGTDGILA 730
+ + V KK+ EE P + +K +E +E +
Sbjct: 10179 PKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEVLPVEVT 10238
Query: 731 GSQEHDPGQGSSSPEQAGSPTEGEGVS---TWESFKRLVTPRKKSKSKLEEKSEDSIAGS 787
E +P PE+ S E E V+ E K+ V K E ++
Sbjct: 10239 EEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKK 10298
Query: 788 GVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVV 847
E P KE +P KK P+ K+ P ++A P + V
Sbjct: 10299 IPEEKVPVPVQKKEAPPAK----VPEVPKKVPE-KKVLVPKKEAVPPAKGRTVLEEKVSV 10353
Query: 848 PLSEYDAVEREKMEAQQAQKSAEQ-PEQKAATEVSKELSESQVHMMAAAVADGTRAATII 906
+ + V +E++E + + E+ PE++ EV + E + H + + +
Sbjct: 10354 AFRQ-EVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIK--LEQHRVE 10410
Query: 907 EERSPSWISASV----TEPLEQVEAEAALLTEEVLEREVIAEEEPPTVT----EPLPENR 958
EE + + E +E E A + ++I ++PPT EP +
Sbjct: 10411 EEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVP 10470
Query: 959 EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEE 1018
E VV E PE T P E E V + P E
Sbjct: 10471 EVPKKIVVEEKVRVPEEPRVPPTKVP---EVLPPKEVVPEKKVPVPPAKKPEAPPPKVPE 10527
Query: 1019 ATP--VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAER 1076
A V E + VP ++ E +V + V + E ++P P+ P + EA +
Sbjct: 10528 APKEVVPEKKVPVPPPKKPEVPPTKVPE-VPKAAVPEKKVPEAIPPKPESPPPEVPEAPK 10586
Query: 1077 ---PEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESS 1133
PE++ A+ KK V V EA E + KV P K P+V +
Sbjct: 10587 EVVPEKKVPAAPPKKPE--VTPVKVPEAPKEVVPEKKV-----PVPPPKKPEVPPT---- 10635
Query: 1134 ELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDE-IV 1192
+ + V E + +AIPP E+P P F+ P +E
Sbjct: 10636 ------KVPEVPKVAVPEKKVPEAIPP-KPESP---------PPEVFEEPEEVALEEPPA 10679
Query: 1193 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252
E+ EE E A+ Q + VP +K AP + V ++ K+ + + E V
Sbjct: 10680 EVVEEPEPAAPPQVTVPPKKPVPEKK----AP-AVVAKKPELPPVKVPEVPKEVVPEKKV 10734
Query: 1253 ETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEA 1312
V + + K +VP E + + V ++ A E ++
Sbjct: 10735 PLV--------VPKKPEAPPAKVPEVP----KEVVPEKKVAVPKKPEVPPAKVPEVPKKP 10782
Query: 1313 ECKKDDALELQSHAKSPPSPV---EREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEE 1369
++ A+ + A+SPP V E+ + E E +P V EE+ E E E
Sbjct: 10783 VLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEE-EPEVPPPAVPE 10841
Query: 1370 VSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTK 1409
K+++ VP+I + +PPP + E V K
Sbjct: 10842 EPKKIIPEKKVPVIKKPE-------APPPKEPEPEKVIEK 10874
Score = 80.1 bits (196), Expect = 2e-14
Identities = 319/1546 (20%), Positives = 548/1546 (35%), Gaps = 263/1546 (17%)
Query: 231 EPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGE----EKQEKEPSKSAESPTS 286
+P +KP K++++ PPA+ + ++ +E+ +K++ P+K E P
Sbjct: 9956 KPVPEEKKPVPVPKKKEA-----PPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKK 10010
Query: 287 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEV- 345
PV E K PK+ VEA K + P+K E+ K V
Sbjct: 10011 PVPEE------------------KVPVPVPKK--VEAPPAKVPEVPKKPVPEK--KVPVP 10048
Query: 346 ASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD 405
A +K+ A P+ P + E E + +P + + + P + +P P+ +
Sbjct: 10049 APKKVEAPPAKVPEVPKKLIPE-----EKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQ 10103
Query: 406 EKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVK 465
E+ + +EE+V E V EE ++ EV +P EE E+ E +E P +E V
Sbjct: 10104 EEEVLFEEEIVPEEEVLPEEEEVLPEEEEV------LPEEE--EVLPEEEEIPPEEEEVP 10155
Query: 466 LKETCVSGEDPTQGADLSPDEKVLS--KPPEGVVSEVEMLSSQERMKVQGSPLKKLFTST 523
+E V E+ + P+E+VL KP V + V + + K P K+
Sbjct: 10156 PEEEYVPEEE-----EFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPA 10210
Query: 524 GLKKLSGKKQKGKRGGGDEESG---EHTQVPADSPDSQEEQKGESSASSPEEPEEIT--- 577
+ ++ K ++ + EE E T+ P + P S+EE E S EE EE+
Sbjct: 10211 KVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPP--SIEEVEEVAPPR 10268
Query: 578 ---CLEKGLAE----VQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESD 630
++K + E V + EA S +K E P KK P K P +
Sbjct: 10269 VPEVIKKAVPEAPTPVPKKVEAPPAKVS--KKIPEEKVPVPVQKKEAPPAKVPEVPKKVP 10326
Query: 631 KEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKK 690
++ L K A + T E K SV + K +++ V EA + ++
Sbjct: 10327 EKKVLVPKKEAVPPAKGRTVLEE----KVSVAFRQEVVVKERLELEVV-EAEVEEIPEEE 10381
Query: 691 RARRGSSSDEEGG----PKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQ 746
EEG + + + + +E + ++ + ++E + + +P +
Sbjct: 10382 EFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPK 10441
Query: 747 AGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVE-HSTPDTEPGKEESWV 805
P E + + V PRK+ +K+ E + + V P P K +
Sbjct: 10442 G--PEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVL 10499
Query: 806 SIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQA 865
K+ +P ++ P K+ +AP P VP + + V +K+
Sbjct: 10500 PPKEVVPEKKVPVPPAKKPEAP----------------PPKVPEAPKEVVPEKKVPVPPP 10543
Query: 866 QKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQV 925
+K P + EV K A + E++ P I P +V
Sbjct: 10544 KKPEVPPTK--VPEVPK--------------------AAVPEKKVPEAIPPKPESPPPEV 10581
Query: 926 EAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPL 985
+EV+ E++ P PE T V E E V E P+
Sbjct: 10582 PEAP---------KEVVPEKKVPAAPPKKPEV------TPVKVPEAPKEVVP--EKKVPV 10624
Query: 986 GAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQA 1045
+ E T P+ + A P ++V +P + E EV +
Sbjct: 10625 PPPKKPEVPP--------------TKVPEVPKVAVPEKKVPEAIPP--KPESPPPEVFEE 10668
Query: 1046 VAEKVKEESQLPGTGGPEDVLQPVQRAEAERP--EEQAEASGLKKETDVVLKVDAQEAKT 1103
E EE PE P ++P E++A A KK +KV +
Sbjct: 10669 PEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEV 10728
Query: 1104 EPFTQGKVVGQTTPESFE-KAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDS 1162
P + +V PE+ K P+V + + + V + + K E V ++ + +
Sbjct: 10729 VPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPE-VPKKPVLEEK 10787
Query: 1163 VETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEE-NEVASGTQSGGTEAEAVPAQKERP 1221
P + P E++EE E+A + E + VP +E
Sbjct: 10788 PAVPVPERAESPPP----------------EVYEEPEEIAPEEEIAPEEEKPVPVAEEEE 10831
Query: 1222 PAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYAD---EKTK-- 1276
P EE K K + + V ++ K E + + EK K
Sbjct: 10832 PEVPPPAVPEEPK-------------KIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLK 10878
Query: 1277 -------DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECK----KDDALELQSH 1325
P E ++ I + ++KV E E E K + +L
Sbjct: 10879 PRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPE 10938
Query: 1326 AKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDG 1385
K P P E ++ V R++ E E V +KLE V E + ++ V VP +
Sbjct: 10939 RK--PEPKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTV-- 10994
Query: 1386 AKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLE 1445
+E + +V + + L A + K E I E
Sbjct: 10995 --------------TKRERKIPEPTKVPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPE 11040
Query: 1446 PAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGP-DCQAKSTPVIVSATTKKGLSSDLEGEK 1504
P + K + A E A P GP K TP + A +K L GEK
Sbjct: 11041 PTPIAAPVTVPVVGKKAEAKAPKEEAAKPKGPIKGVPKKTPSPIEAERRK-LRPGSGGEK 11099
Query: 1505 TTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETK---SSKLVQNII--QTAVD 1559
DE ++K +V ++ ++ I+ E++ SS + + ++ TA+
Sbjct: 11100 PP---------DEAPFTYQLK-AVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAIT 11149
Query: 1560 QFVR-----TEETATEMLTSELQTQAHVIKADSQDAGQET------EKEGEEPQASAQDE 1608
+++ E + + H+I DAG+ T KE +E
Sbjct: 11150 TWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEE 11209
Query: 1609 TPITSAK--EESESTAVGQ-----AHSDISKDMSEASEKTMTVEVEGSTVNDQ-QLEEVV 1660
P+ K EE + GQ + +D+ + + VE G V L +
Sbjct: 11210 LPVRFVKTLEEEVTVVKGQPLYLSCELNKERDVVWRKDGKIVVEKPGRIVPGVIGLMRAL 11269
Query: 1661 LPSEEEGGGAGTKSVPEDDGHAL-------LAERIEKSLVEPKEDE 1699
++ + AGT +V ++ + L + E I LV+P D+
Sbjct: 11270 TINDADDTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQ 11315
Score = 49.7 bits (117), Expect = 3e-05
Identities = 98/522 (18%), Positives = 203/522 (38%), Gaps = 68/522 (13%)
Query: 28 SGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGA 87
+G S A+ A+ + + K+ ++T+ VA D ++E ++ +
Sbjct: 392 AGAAASVSASASYAAEAVATGAKEVKQDADKSAAVATV--VAAVDMARVREPVISAVE-- 447
Query: 88 LNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQ--EETPEI 145
Q + T V + +++ +++++K TK V D + + T E+
Sbjct: 448 ---------QTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQELKSRTKEV 498
Query: 146 I----EQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTV 201
I EQ+ + + + T+ T I K + + + ++ T+K V +
Sbjct: 499 ITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAKEQ---ETRISEEITKKQKQVTQEAI 555
Query: 202 KKDEGEGAAG---AGDHKDPSLGAGEAASKESEPKQ-----STEK-PEETLKREQSHAEI 252
+++ AA K L A +E+ +Q S EK +ET K +
Sbjct: 556 RQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVVPKVIV 615
Query: 253 SPPAESGQAVEECKEEG-----------EEKQEKEPSKSAESPTSPVTSETGSTFKKFFT 301
+ P Q + EG +EK KE K+A S + T++
Sbjct: 616 ATPKVKEQDLVSRGREGITTKREQVQITQEKMRKEAEKTALSTIAVATAKA--------- 666
Query: 302 QGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEP 361
+++ + + +E E+ + KVD + KAE + + A +QA +EP
Sbjct: 667 ------KEQETILRTRETMATRQEQIQVTHG-KVDVGK--KAEAVATVVAAVDQARVREP 717
Query: 362 AESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHV 421
E H A+ +E +E++S ++ + V + ++ + +E H+
Sbjct: 718 REPGHLEESYAQQTTLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRVIQAPSETHI 777
Query: 422 STVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLK--ETCVSGEDPTQG 479
T +++ +++++T + E LV +D P+ A P + K+ +T E G
Sbjct: 778 KTTDQKGMHISSQIKKTT-DLTTERLVHVDKRPRTASPHFTVSKISVPKTEHGYEASIAG 836
Query: 480 ADLSPDEKVLSKPPEG-----VVSEVEMLSSQERMKVQGSPL 516
+ ++ +K LS V + S+ R++ + +PL
Sbjct: 837 SAIATLQKELSATSSAQKITKSVKAPTVKPSETRVRAEPTPL 878
Score = 47.8 bits (112), Expect = 1e-04
Identities = 120/544 (22%), Positives = 195/544 (35%), Gaps = 101/544 (18%)
Query: 218 PSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEP 277
P + E E+ P + P E + + A PPAE EE + P
Sbjct: 10641 PKVAVPEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEV----------VEEPEPAAP 10690
Query: 278 SKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDT 337
+ P PV + +KP+ V+ E KE PEK
Sbjct: 10691 PQVTVPPKKPVPEKKAPA---------------VVAKKPELPPVKVPEVPKEVVPEK--- 10732
Query: 338 EEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP-SEEKP 396
V +K A P+ P E E +++ +K E+P + + P EEKP
Sbjct: 10733 ---KVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVP-KKPEVPPAKVPEVPKKPVLEEKP 10788
Query: 397 A-PLATEVFDEKIEVHQ--EEVVAEVHVSTVEER----TEEQKTEVEETAGSVPAEELVE 449
A P+ EV++ EE+ E ++ EE+ EE++ EV A
Sbjct: 10789 AVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPA---------- 10838
Query: 450 MDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPP--------EGVVSEVE 501
+ EP++ P K++ +K+ + + K+ +PP E V ++
Sbjct: 10839 VPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIF 10898
Query: 502 MLSSQERMKVQGSP-LKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEE 560
L + + KV P + + T LK G+K+ K +P P+ +EE
Sbjct: 10899 QLKAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRK------------LLPERKPEPKEE 10946
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPK 620
+S E EE K L +V++ E E+ ++ T
Sbjct: 10947 VVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEE-----------VEVPTVT 10995
Query: 621 KRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE 680
KR R+ E K E +K A + + E+K +P P EP+ T ++
Sbjct: 10996 KRERKIPEPTKVPE---IKPAIPLPAPEPKPKPEAEVK--TIKPPPVEPE---PTPIA-- 11045
Query: 681 ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQG 740
A + V K+A + +E P K G K+T + I A ++ PG G
Sbjct: 11046 APVTVPVVGKKAEAKAPKEEAAKP--------KGPIKGVPKKTPSP-IEAERRKLRPGSG 11096
Query: 741 SSSP 744
P
Sbjct: 11097 GEKP 11100
Score = 42.0 bits (97), Expect = 0.005
Identities = 179/912 (19%), Positives = 327/912 (35%), Gaps = 181/912 (19%)
Query: 939 REVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEE 998
R V EE PP V P+P L P T E P E T+ + ++
Sbjct: 8950 RAVPPEEIPPVVAPPIP--------------LLLP---TPEEKKPPPKRIEVTKKAVKKD 8992
Query: 999 TTEMVSAVSQLTDSPDTTEE-ATPVQEVEGGVPDIEEQERRTQEV----------LQAVA 1047
++V+ ++T + ++ P + P+I + + +EV +Q
Sbjct: 8993 AKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEK 9052
Query: 1048 EKVKEESQ---------LPGTGGPEDVL------QPVQRAEAERPEEQAEASGLKKETDV 1092
E V E+ Q + P D L +P ++ E P+E E E V
Sbjct: 9053 EAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEEPDEDYE------EIKV 9106
Query: 1093 VLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEM 1152
K + E E F +G+ + E + E+ + E++ Q + +S E
Sbjct: 9107 EAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVI---QVQKEVYEESHER 9163
Query: 1153 VMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1212
+ +P + P + + + ++E V++ + EV+ +
Sbjct: 9164 KVPAKVP--EKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSK---------K 9212
Query: 1213 AVPAQKERPPAPSSFVFQE----ETKEQSKMEDTL---EHTDKEVSVETVSILSKTEGTQ 1265
VP + R P + + TK+ E+ + HT++EVSV TV + K T+
Sbjct: 9213 IVPQKPSRTPVQEEVIEVKVPAVHTKKMVISEEKMFFASHTEEEVSV-TVPEVQKEIVTE 9271
Query: 1266 EADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSH 1325
E A K + P KV E+ K E A +E
Sbjct: 9272 EKIHVAISKRVEPP-----------------PKVPELPEKPAPEEVAPVPIPKKVE---- 9310
Query: 1326 AKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDG 1385
PP+P V +V ++ E V K E V E K + +
Sbjct: 9311 ---PPAP----KVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPE--------- 9354
Query: 1386 AKEVSSLEGSPPPCLGQEEAVCTKI-QVQSSEASFTLTAAAEEEKVLGETANILETGETL 1444
E P P ++EA K+ +VQ EEK+ T +
Sbjct: 9355 -------EKIPVPVAKKKEAPPAKVPEVQK--------GVVTEEKITIVTQREESPPPAV 9399
Query: 1445 EPAGAHLVLEEKS--SEKNEDFAAHPGEDAVPTGPDCQAK-STPVIVSATTKKGLSSDLE 1501
V EE+ K E+ P A+P P + K + PV V+ KK E
Sbjct: 9400 PEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVA---KKAPPPRAE 9456
Query: 1502 GEKTTSLKWKSDEVDEQVAC---QEVKVS---VAIED----LEPENGILELETKSSKLVQ 1551
K T ++ K +E+++ Q V+V+ V+ E+ E E G+ + + +
Sbjct: 9457 VSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGV-SISVYREEERE 9515
Query: 1552 NIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEK----------EGEEP 1601
+ V ++ EE ++ +L + ++A+ + + EK + EEP
Sbjct: 9516 EEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEP 9575
Query: 1602 QASAQDETP--------ITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVE---GST 1650
+ E P + + + E + + K + E +++E +
Sbjct: 9576 PPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAK 9635
Query: 1651 VNDQQL----EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDD 1706
V ++ + EE VL + + VPE+ A+ E++ K ++PK +E+
Sbjct: 9636 VTERHMQITQEEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLK--LKPKREEE------ 9687
Query: 1707 PENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGK--VHSESDKAITPQAQ 1764
T+ + KE + ++E + +EV + E K ++ ++A++ Q +
Sbjct: 9688 -----PPAKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQRE 9742
Query: 1765 EELQKQERESAK 1776
EE ++ E K
Sbjct: 9743 EEYEEYEEYDYK 9754
Score = 41.6 bits (96), Expect = 0.007
Identities = 102/479 (21%), Positives = 169/479 (35%), Gaps = 57/479 (11%)
Query: 743 SPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEE--------KSEDSIAGSGVEHS-- 792
SP ++ SP S S + + RK S + K E +A S
Sbjct: 302 SPVRSVSPAARISTSPIRSVRSPLLMRKTQASTVATGPEVPPPWKQEGYVASSSEAEMRE 361
Query: 793 ---TPDTEPGKEESW-----VSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSD-- 842
T T+ EE W V + I G + +A TGA E D
Sbjct: 362 TTLTTSTQIRTEERWEGRYGVQEQVTISGAAGAAASVSASASYAAEAVATGAKEVKQDAD 421
Query: 843 ----VPAVVPLSEYDAVEREKMEA--QQAQKSAEQPE--QKAATEVSKELSESQVHMMAA 894
V VV + V + A Q AQ++ Q A +V KE ++ V +
Sbjct: 422 KSAAVATVVAAVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVV 481
Query: 895 AVADGTRAATIIEERSPSWISAS-----VTEPLEQVEAEAALLTEEVLEREVIAEEEPPT 949
A AD + + + R+ I+ VT + E E + + V+ E+E
Sbjct: 482 A-ADKAKEQEL-KSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAKAKEQETRI 539
Query: 950 VTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETT--------- 1000
E + ++ + + E E+T ++ TA E T A EETT
Sbjct: 540 SEEITKKQKQVTQEAIRQETEITAASMVVVATAKSTKLE--TVPGAQEETTTQQDQMHLS 597
Query: 1001 -EMVSAVSQLTDSPDTTEEATPVQEVE------GGVPDIEEQERRTQEVLQAVAEKVKEE 1053
E + ++ T P V+E + G+ EQ + TQE ++ AEK
Sbjct: 598 YEKIMKETRKTVVPKVIVATPKVKEQDLVSRGREGITTKREQVQITQEKMRKEAEKTALS 657
Query: 1054 SQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVG 1113
+ T ++ + + R Q + + DV K +A Q +V
Sbjct: 658 TIAVATAKAKE-QETILRTRETMATRQEQIQVTHGKVDVGKKAEAVATVVAAVDQARVRE 716
Query: 1114 QTTPESFEK--APQVTESIESSELVTTCQ-AETLAGVKSQEMVMEQAIPPDSVETPTDS 1169
P E+ A Q T E ++ + AE S+ V+ +A+ P ++ P+++
Sbjct: 717 PREPGHLEESYAQQTTLEYGYKERISAAKVAEPPQRPASEPHVVPKAVKPRVIQAPSET 775
Score = 35.0 bits (79), Expect = 0.65
Identities = 106/496 (21%), Positives = 179/496 (36%), Gaps = 62/496 (12%)
Query: 320 EVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE-PAESAHEPRLSAEYEKVE 378
E AS + K E+ EE L A P+ R S + +
Sbjct: 32529 EHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEP 32588
Query: 379 LPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEE-------- 430
+P+ + Q S + T + E+ + E + S V E +E
Sbjct: 32589 VPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTL 32648
Query: 431 --QKTEVEETA-GSVPAEELVEMDAEPQEAEPAKELVKLKETC-VSGEDPTQGADLSPDE 486
QK V E A S P + E + EA + + VK E PT+ +P E
Sbjct: 32649 TIQKARVTEKAVTSPPRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKP-TPTE 32707
Query: 487 KVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGE 546
KV P + L ++ ++ KL L K+ + G +
Sbjct: 32708 KVQHLPVSAPPKITQFLKAEASKEIA-----KLTCVVESSVLRAKEVTWYKDGKKLKENG 32762
Query: 547 HTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREG 606
H Q S D E K + S + E C G EG TS + G
Sbjct: 32763 HFQFHY-SADGTYELKINNLTESDQG--EYVCEISG-----------EGGTSKTNLQFMG 32808
Query: 607 VTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKP 666
+FK + ++V + SE+ K D+ +TEST + E KP
Sbjct: 32809 ----QAFKSI---HEKVSKISETKKSDQ---------KTTESTVTRKTEPKAPEPISSKP 32852
Query: 667 EEPKRKVDTSVSWEALICVG-SSKKRARRGSSSDEEGGPKAMGGDHQKADEAG------K 719
DT+VS +++ + R + ++G GG ++ +++ G
Sbjct: 32853 VIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIH 32912
Query: 720 DKETGTDGILAGSQEHDPGQGSSSPE---QAGSPTEGEGVSTWESFKRLVTPRKKSKSKL 776
+T G+ + ++ G SSS + +A TE + VST ++ + +TP+KK+ +
Sbjct: 32913 KTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKTSE--ITPQKKAVVQ- 32969
Query: 777 EEKSEDSIAGSGVEHS 792
EE S+ ++ ++ S
Sbjct: 32970 EEISQKALRSEEIKMS 32985
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 91.7 bits (226), Expect = 6e-18
Identities = 133/611 (21%), Positives = 231/611 (37%), Gaps = 90/611 (14%)
Query: 99 EEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEE 158
EE+ T+V + +E+ K ++E + + + G+EET EE
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET---------KSPPAEE 508
Query: 159 LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDP 218
P + + + K++ + P K E E A + K P
Sbjct: 509 AASPEKEAKSPV----------------KEEAKSP-----AEAKSPEKEEAKSPAEVKSP 547
Query: 219 SLGAGEAASKESEPKQSTEKPEETLKREQSHAEI-SPPAESGQAVEECKEEGEEKQE--- 274
A + P ++ +E K S AE+ SP A EE K E K
Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAK---SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604
Query: 275 ----KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQ 330
KE +KS SPV E S A + + P ++E ++ EK K
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAKSP---------AEVKSPEKAKSPTKEEAKSPEKAKSP 655
Query: 331 EPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELP-------SEE 383
E E+ + E K+ V +E + + P + + E S E+ + P EE
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 715
Query: 384 QVSGSQGPS---EEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAG 440
S + S EE P + ++ E+ + T++ ++ E KT +E A
Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775
Query: 441 SVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV 500
S PA++ E + P KE VK E + P + +P++++ K E V S V
Sbjct: 776 S-PADKFPE-----KAKSPVKEEVKSPE---KAKSPLKEDAKAPEKEIPKK--EEVKSPV 824
Query: 501 EMLSSQERMKVQGSPL-----KKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSP 555
+ + +KV+ P K T +K KK++ + + E + PA
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPA--V 882
Query: 556 DSQEEQKGESSASSPEEPEEITCLEK---GLAEVQQDGEAEEGA-----TSDGEKKREGV 607
+ +E K E+ E+ +++ EK EV++D + +E D K +E
Sbjct: 883 EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPS 942
Query: 608 TP----WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEE 663
P A+ +K T +++ ++P E K + K TLS S + E S ++
Sbjct: 943 KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 664 PKPEEPKRKVD 674
+ P++ +
Sbjct: 1003 KDSKPPEKATE 1013
Score = 89.4 bits (220), Expect = 3e-17
Identities = 149/599 (24%), Positives = 243/599 (40%), Gaps = 57/599 (9%)
Query: 309 KKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTA--SEQAHPQEPAESAH 366
K+T + + +E + +E+ E+E ++ EE+GK E E+ A E+ PAE A
Sbjct: 452 KETVIVEEQTEETQVTEEVTEEEEKEA-KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAA 510
Query: 367 EPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEE 426
P A+ V+ ++ EE +P + ++ +EE + + E+
Sbjct: 511 SPEKEAK-SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 427 RTEEQKTEVE--ETAGSVPAEELVEMDAEPQEAEPAKELVKLK-ETCVSGEDPTQGADLS 483
+ EV+ E A S PA+E + AE + E AK VK + ++ + P + S
Sbjct: 570 EEAKSPAEVKSPEKAKS-PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Query: 484 PDE-----------KVLSKPPEGVVS-EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGK 531
P E K +K PE S E E S E+ K SP+K S K S
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK---SPVKAEAKSPE-KAKSPV 684
Query: 532 KQKGKRGGGDEESGEHTQVPADSPDS-----QEEQKGESSASSPEEPEEITCLEKGLAEV 586
K + K E++ + A SP+ +EE K A SP + EE EK + V
Sbjct: 685 KAEAK---SPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK-EEAKTPEKAKSPV 740
Query: 587 QQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSST 646
+++ ++ E A S + K V S + K+ R P++ E VK + S
Sbjct: 741 KEEAKSPEKAKSPEKAKTLDV---KSPEAKTPAKEEARSPADKFPEKAKSPVKE-EVKSP 796
Query: 647 ESTASEMQEEMKGSVEE-PKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPK 705
E S ++E+ K +E PK EE K V + + K+ ++ PK
Sbjct: 797 EKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV----KVKEPPKKAEEEKAPATPK 852
Query: 706 AMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRL 765
K +EA K KE + E P+++ + E E K++
Sbjct: 853 TEEKKDSKKEEAPK-KEAPKPKV-----EEKKEPAVEKPKESKVEAKKEEA---EDKKKV 903
Query: 766 VTPRKKSKSKLEEKSE-DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQE 824
TP K++ +K+E K + + V PD KE S + KK +K D K+E
Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK---DTKEE 960
Query: 825 QAPVEDAGP-TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 882
+A + P T A + D S+ A + EK + QK ++ PE+ + +K
Sbjct: 961 KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD-QKDSKPPEKATEDKAAK 1018
Score = 89.0 bits (219), Expect = 4e-17
Identities = 133/602 (22%), Positives = 221/602 (36%), Gaps = 70/602 (11%)
Query: 531 KKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDG 590
+K+ + G +EE GE +E + GE SP E + ++ + V+++
Sbjct: 475 EKEAKEEEGKEEEGGEE----------EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEA 524
Query: 591 EAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKS-ATLSSTEST 649
++ A S +++ + S +K +P K + K E ++ KS A + S E
Sbjct: 525 KSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA 584
Query: 650 ASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG 709
S +EE K E PE+ K V +K A S EE A
Sbjct: 585 KSPAKEEAKSPAEAKSPEKAKSPVKE-----------EAKSPAEAKSPVKEEAKSPAEVK 633
Query: 710 DHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPR 769
+KA K++ + + +E + SPE+A SP + E S E K V
Sbjct: 634 SPEKAKSPTKEEAKSPEKAKSPEKEE-----AKSPEKAKSPVKAEAKSP-EKAKSPVKAE 687
Query: 770 KKSKSKL-----EEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQE 824
KS K EE A S V+ P K +S V + P + K P ++
Sbjct: 688 AKSPEKAKSPVKEEAKSPEKAKSPVKEEA--KSPEKAKSPVKEEAKTP-EKAKSPVKEEA 744
Query: 825 QAPVEDAGPTGANEDDSDVP-AVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKE 883
++P + P A D P A P E +K + KS + E K+ +
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKF--PEKAKSPVKEEVKSPEKAKSP 802
Query: 884 LSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIA 943
L E + + EE P V EP ++ E E A T + E++
Sbjct: 803 LKEDAKAPEKEIPKKEEVKSPVKEEEKPQ--EVKVKEPPKKAEEEKAPATPKTEEKKDSK 860
Query: 944 EEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMV 1003
+EE P P P+ E + V E EA + AE+ ++
Sbjct: 861 KEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA----------------KKEEAEDKKKVP 904
Query: 1004 SAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ + + E+A P ++ E V E + + +E + +K PE
Sbjct: 905 TPEKEAPAKVEVKEDAKPKEKTE--VAKKEPDDAKAKEPSKPAEKK---------EAAPE 953
Query: 1064 DVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKA 1123
+ + +A++PEE+ + KE D L + + K E + Q + EKA
Sbjct: 954 K--KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKA 1011
Query: 1124 PQ 1125
+
Sbjct: 1012 TE 1013
Score = 82.8 bits (203), Expect = 3e-15
Identities = 160/676 (23%), Positives = 257/676 (38%), Gaps = 94/676 (13%)
Query: 316 PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYE 375
PK V K K +E KV E+ K V E+ T Q +E E + E +
Sbjct: 427 PKIPSVSTHIKVKSEEKIKV-VEKSEKETVIVEEQTEETQV-TEEVTEEEEKEAKEEEGK 484
Query: 376 KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEV 435
+ E EE+ G + ++ PA A E +EE + + E+ + EV
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 436 E--ETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPP 493
+ E A S PA+E E + P+ P KE K A++ EK S
Sbjct: 545 KSPEKAKS-PAKE--EAKSPPEAKSPEKEEAK------------SPAEVKSPEKAKSPAK 589
Query: 494 EGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPAD 553
E S E S E+ K SP+K+ S K K++ + + +S E + P
Sbjct: 590 EEAKSPAE-AKSPEKAK---SPVKEEAKSPAEAKSPVKEE--AKSPAEVKSPEKAKSP-- 641
Query: 554 SPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASF 613
++EE K A SPE+ EE EK + V+ + ++ E A S K E +P
Sbjct: 642 ---TKEEAKSPEKAKSPEK-EEAKSPEKAKSPVKAEAKSPEKAKS--PVKAEAKSP---- 691
Query: 614 KKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKV 673
+K +P K + E K ++ K S E S ++EE K PE+ K V
Sbjct: 692 EKAKSPVKEEAKSPEKAKSPVKEEAK-----SPEKAKSPVKEEAK------TPEKAKSPV 740
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+A + K+ E K + + ++
Sbjct: 741 K-----------------------------EEAKSPEKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
E PE+A SP + E S ++ L K + ++ +K E + E
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE--VKSPVKEEEK 829
Query: 794 PDTEPGKEESWVSIKKFIPG--RRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSE 851
P KE + ++ P + +++ D K+E+AP ++A E PAV E
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE--PAVEKPKE 887
Query: 852 YDAVEREKMEAQQAQK-SAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERS 910
VE +K EA+ +K + E A EV ++ + +A D +A E
Sbjct: 888 -SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK---EPSK 943
Query: 911 PSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTV----TEPLPENREARGDTVV 966
P+ + E + E E A EE + E A+E+ T+ ++P E E T
Sbjct: 944 PAEKKEAAPEKKDTKE-EKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ 1002
Query: 967 SEAELTPEAVTAAETA 982
+++ PE T + A
Sbjct: 1003 KDSK-PPEKATEDKAA 1017
Score = 81.3 bits (199), Expect = 8e-15
Identities = 116/532 (21%), Positives = 201/532 (37%), Gaps = 50/532 (9%)
Query: 5 SSTEQRSPEQPPEGSSTPAE---PEPSGGGPSAEA-APDTTADPAI--AASDPATKLLQK 58
+S E+ + E + +PAE PE AE +P+ PA A S P K +K
Sbjct: 510 ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEK 569
Query: 59 NGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDV-SK 117
S + + S + + A + + A + +EE E E+ S
Sbjct: 570 EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSP 629
Query: 118 RDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFK 177
+ KS + + ++PE E + E+ P +++A K
Sbjct: 630 AEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA-----KSPEKAKSPVKAEAKSPEKAKSPV 684
Query: 178 FVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEP-KQST 236
K K K + K E A K P + K P K+
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 237 EKPEETLKREQSHA-EISPPAESGQAVEECKEEGEEKQEKEPS------KSAESPTSPVT 289
+ PE+ E++ ++ P A EE + ++ EK S KS E SP+
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 290 SETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEK 349
+ + K+ KK + P ++E + E K ++ P+K + E+ EK
Sbjct: 805 EDAKAPEKEI--------PKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856
Query: 350 LTASEQAHPQEPAESAHEPRLSAEYEK-VELPSEEQVSGSQGPSEEKPAPLATEVFDEKI 408
+ ++ + P + A +P++ + E VE P E +V + +E+K +K+
Sbjct: 857 KDSKKE---EAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDK----------KKV 903
Query: 409 EVHQEEVVAEVHV---STVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVK 465
++E A+V V + +E+TE K E ++ P++ + +A P++ + +E K
Sbjct: 904 PTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK 963
Query: 466 LKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLK 517
E E P A D+K LSK P +E SS K P K
Sbjct: 964 KPE-----EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEK 1010
Score = 80.5 bits (197), Expect = 1e-14
Identities = 139/593 (23%), Positives = 230/593 (38%), Gaps = 84/593 (14%)
Query: 185 VKKDKTEKPDTVQLLTVKKD----EGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPE 240
+ +++TE+ + +T +++ E EG G ++ + G GE +K S P + PE
Sbjct: 456 IVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG-GEEETK-SPPAEEAASPE 513
Query: 241 ETLKREQSHAEISPPAESGQAVEECKE-EGEEKQEKEPSKSAESPTSPVTSETGS----- 294
+ K SP E ++ E K E EE + KS E SP E S
Sbjct: 514 KEAK--------SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK 565
Query: 295 TFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASE 354
+ +K + A + + P ++E ++ + K E K +E+ K+ ++ E
Sbjct: 566 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEE 625
Query: 355 QAHPQE----------PAESAHEPRLSAEYEKVELPSEEQVSG-----SQGPSEEKPAPL 399
P E E A P + EK E S E+ ++ P + K
Sbjct: 626 AKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK 685
Query: 400 ATEVFDEKIE--VHQEEVVAEVHVSTVEERT---EEQKTEVEETAGSVPAEELVEMDAEP 454
A EK + V +E E S V+E E+ K+ V+E A P + + E
Sbjct: 686 AEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA-KTPEKAKSPVKEEA 744
Query: 455 QEAEPAKELVKLKETCVSGED---PTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKV 511
+ E AK K K V + P + SP +K K V EV+ S E+ K
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK---SPEKAK- 800
Query: 512 QGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQ-----KGESS 566
SPLK+ + +K KK++ K +EE + +V ++EE+ K E
Sbjct: 801 --SPLKE--DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856
Query: 567 ASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRV--- 623
S +E K E +++ E+ S E K+E KK+ TP+K
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA---EDKKKVPTPEKEAPAK 913
Query: 624 ------RRPSE----SDKEDELDKVKSATLSSTESTAS-----EMQEEMKGSVEEPKPEE 668
+P E + KE + K K + + + A+ +E+ K E+PK E
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEA 973
Query: 669 PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDK 721
++ D ++S E SK +A + S + + D+A K K
Sbjct: 974 KAKEDDKTLSKE------PSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 72.0 bits (175), Expect = 5e-12
Identities = 140/595 (23%), Positives = 233/595 (39%), Gaps = 85/595 (14%)
Query: 1228 VFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGS 1287
+ +E+T+E E+ E +KE E + G +E + +E+TK P E
Sbjct: 456 IVEEQTEETQVTEEVTEEEEKEAKEEEGK--EEEGGEEEEAEGGEEETKSPPAEEA---- 509
Query: 1288 IDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHA--KSPP---SPVEREMVVQVE 1342
S EK + +K E AE K + E +S A KSP SP + E E
Sbjct: 510 ------ASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 1343 REKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQT-----VNVPIIDGAKEVSSLEGSPP 1397
+ E E E E A + ++E +K + P+ + AK S E P
Sbjct: 564 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK--SPAEAKSP 621
Query: 1398 PCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEP--AGAHLVLEE 1455
+E + +V+S E + + T +EE E A E E P A + + E
Sbjct: 622 V----KEEAKSPAEVKSPEKAKSPT---KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 1456 KSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEV 1515
KS EK A A P+ +AKS PV A + + S ++ E + K KS
Sbjct: 675 KSPEK-----AKSPVKAEAKSPE-KAKS-PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVK 727
Query: 1516 DEQVACQEVKVSVAIEDLEPENG-------ILELETKSSKL-VQNIIQTAVDQF------ 1561
+E ++ K V E PE L++++ +K + ++ D+F
Sbjct: 728 EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 1562 -VRTEETATEMLTSELQTQAHVIKADSQDAGQETE-----KEGEEPQASAQDETPITSAK 1615
V+ E + E S L+ A KA ++ ++ E KE E+PQ E P + +
Sbjct: 788 PVKEEVKSPEKAKSPLKEDA---KAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844
Query: 1616 EESESTAVGQAHSDISKDMSEASEKTMT-VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKS 1674
E++ +T + D K+ + E VE + ++ E V +EE
Sbjct: 845 EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP 904
Query: 1675 VPEDDGHALL-----AERIEKSLVEPKE--DEKGDDVDDPENQNSALADTDASGGLTKES 1727
PE + A + A+ EK+ V KE D K + P + A E
Sbjct: 905 TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA----------APEK 954
Query: 1728 PDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1782
DT K K+ E+ + E + E DK ++ + + ++ +S+ ++ +S
Sbjct: 955 KDTKEEKAKKPEEKPKTEAKA----KEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Score = 71.2 bits (173), Expect = 8e-12
Identities = 149/722 (20%), Positives = 275/722 (38%), Gaps = 75/722 (10%)
Query: 843 VPAVVPLSEYDAVEREKM-EAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGT- 900
V + + E+ V +++ EA + A + Q+ TE ++L + A +
Sbjct: 283 VQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSL 342
Query: 901 -RAATIIEERSPSWISASVTEPLEQVEAE--------AALLTE--EVLEREVIAEEEPPT 949
R + +E+R + I AS E ++Q++AE AA L E ++L ++ + E
Sbjct: 343 ERQRSELEDRHQADI-ASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAA 401
Query: 950 VTEPLPENREAR---GDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAV 1006
+ L E E R G S E P+ + + T + +EE + E++ + V
Sbjct: 402 YRKLL-EGEECRIGFGPIPFSLPEGLPK-IPSVSTHIKVKSEE--KIKVVEKSEKETVIV 457
Query: 1007 SQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVL 1066
+ T+ TEE T +E E + +E+E +E + E+ K ++
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAK 517
Query: 1067 QPVQR-----AEAERPE-EQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESF 1120
PV+ AEA+ PE E+A++ K + +EAK+ P + + +
Sbjct: 518 SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAE 577
Query: 1121 EKAPQVTESIESSELVTTCQAETLAGVKS------------QEMVMEQAIPPDSVETPTD 1168
K+P+ +S E + +A++ KS + V E+A P V++P
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 1169 SETDGSTPVADFDAPGTTQKDEIVEIHE-ENEVASGTQS-----GGTEAEAVPAQKERPP 1222
+++ + + +K+E + ++ V + +S +AEA +K + P
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 1223 APSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFE 1282
E+ K K E K E K + + + + EK K +
Sbjct: 698 VKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 1283 GLEGSIDTGITVSREKVTEVA------LKGEGTEEAECKKDDALELQSHAKSPPSPV-ER 1335
L+ T ++E+ A K EE + + L+ AK+P + ++
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817
Query: 1336 EMVVQVEREKTEAEPTHVNE--EKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLE 1393
E V +E+ + + V E +K E E A + K+ D KE + +
Sbjct: 818 EEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK----------DSKKEEAPKK 867
Query: 1394 GSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVL 1453
+P P + +++ + +S E +K E + T E PA +
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESK---------VEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918
Query: 1454 EEKSSEKNEDFAAHPGEDAVPTGPDCQA-KSTPVIVSATTKKGLSSDLEGEKTTSLKWKS 1512
+ K EK E P +DA P A K TK+ + E + T K K
Sbjct: 919 DAKPKEKTEVAKKEP-DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977
Query: 1513 DE 1514
D+
Sbjct: 978 DD 979
Score = 64.3 bits (155), Expect = 1e-09
Identities = 129/556 (23%), Positives = 208/556 (37%), Gaps = 110/556 (19%)
Query: 1238 KMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSRE 1297
K E+ ++ +K ETV + +TE TQ ++ +E+ K+ EG +E
Sbjct: 439 KSEEKIKVVEKSEK-ETVIVEEQTEETQVTEEVTEEEEKEAKEEEG------------KE 485
Query: 1298 KVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEK 1357
+ + EG EE E K A E S K SPV+ E E + E E E
Sbjct: 486 EEGGEEEEAEGGEE-ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 1358 LEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQE-EAVCTKIQVQSSE 1416
E A + ++E +K SPP E E + +V+S E
Sbjct: 545 KSPEKAKSPAKEEAK----------------------SPPEAKSPEKEEAKSPAEVKSPE 582
Query: 1417 ASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTG 1476
+ + A EE K PA A + KS K E A P E P
Sbjct: 583 KA--KSPAKEEAK---------------SPAEAKSPEKAKSPVKEE--AKSPAEAKSPVK 623
Query: 1477 PDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPE 1536
+ AKS + S K S + E + K KS E +E + ++ K V E PE
Sbjct: 624 EE--AKSPAEVKSPEKAK---SPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE 678
Query: 1537 NGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEK 1596
+ KS V+ E + E S ++ +A + A ++
Sbjct: 679 ------KAKSP--------------VKAEAKSPEKAKSPVKEEAK----SPEKAKSPVKE 714
Query: 1597 EGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQL 1656
E + P+ + E+++S +A S + +++ EK T++V+
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP---EKAKSPEKAKTLDVKSPEAKTPAK 771
Query: 1657 EEVVLPS------------EEEGGGAGTKSVPEDDGHALLAERIEKSLVEP--KEDEKGD 1702
EE P+ EE KS ++D A E +K V+ KE+EK
Sbjct: 772 EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQ 831
Query: 1703 DVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAI--T 1760
+V E A + + +P T K +KE+A + E + KV + + A+
Sbjct: 832 EVKVKEPPKKAEEEKAPA------TPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
Query: 1761 PQAQEELQKQERESAK 1776
+++ E +K+E E K
Sbjct: 886 KESKVEAKKEEAEDKK 901
Score = 55.1 bits (131), Expect = 6e-07
Identities = 115/510 (22%), Positives = 198/510 (38%), Gaps = 55/510 (10%)
Query: 1295 SREKVTEVA--LKGEGTE-EAECKKDDALELQS------HAKSPPSPVEREMVVQVEREK 1345
++E++TE L+ TE EA D+LE Q H S E + E
Sbjct: 314 AQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRN 373
Query: 1346 TE---AEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQ 1402
T+ A ++ L + A+ + ++LL+ I G S EG P +
Sbjct: 374 TKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLP-----K 428
Query: 1403 EEAVCTKIQVQSSEASFTLTAAAEEEKVLGE--TANILETGETLEPAGAHLVLEEKSSEK 1460
+V T I+V+S E + +E+E V+ E T T E E EEK +++
Sbjct: 429 IPSVSTHIKVKSEE-KIKVVEKSEKETVIVEEQTEETQVTEEVTEE-------EEKEAKE 480
Query: 1461 NEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVA 1520
E GE+ G + + KS P +A+ +K S ++ E + + KS E +E +
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 1521 CQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQA 1580
EVK + E E KS + + V++ E A E ++ A
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKE----EAKSPAEVKSPEKAKSPAKEEAKSPA 596
Query: 1581 HVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEK 1640
+A S + + K EE ++ A+ ++P+ KEE++S A K +A
Sbjct: 597 ---EAKSPEKAKSPVK--EEAKSPAEAKSPV---KEEAKSPAE-------VKSPEKAKSP 641
Query: 1641 TMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAE--RIEKSLVEPKED 1698
T + EE P + + PE + AE EK+ KE+
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
Query: 1699 EKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKA 1758
K + + A + A + +E+ K KE+A+ E + +++
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 1759 ITPQAQEELQKQER-------ESAKSELTE 1781
+P+A+ +++ R E AKS + E
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKE 791
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 87.8 bits (216), Expect = 8e-17
Identities = 251/1273 (19%), Positives = 421/1273 (33%), Gaps = 182/1273 (14%)
Query: 94 LNSQEE----EEVIVTEVGQRD---SEDVSKRDSDKEMATKSA----VVHDITDDGQEET 142
LNS++E + + + G+ D + KRDS ++ + + V D +DG+ ++
Sbjct: 1331 LNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKS 1390
Query: 143 PEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKF-TVKKDKTEKPDTVQLLTV 201
S L L + E + + + KF + DKT PDT LL
Sbjct: 1391 HSPRASALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTKALLER 1450
Query: 202 KKDEGEGAAGAGDHKD-PSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQ 260
K D S A +K+ E S +P + ++ +
Sbjct: 1451 AKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDD 1510
Query: 261 AVEECKEEGEEKQE--------------------------------------KEPSKSAE 282
E+ KEE +E+QE K+ S+ A
Sbjct: 1511 KKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGAN 1570
Query: 283 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK 342
S T + +F ++K +KPKE E + + + PE +D +
Sbjct: 1571 STTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSE 1630
Query: 343 AEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEE-----KPA 397
+ S E A SA E + + L +EE+ SEE +PA
Sbjct: 1631 LKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPA 1690
Query: 398 PLATEVFDEKIEV----HQEEVVAEVHVSTVEERTEEQKTEVE---ETAGSVPAEELVEM 450
P E E++++ ++ A + E + +Q ++ T G+ ++ +
Sbjct: 1691 PAPVEQL-EQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNV 1749
Query: 451 DAEPQEAEPAKELVKLKETC--VSGEDPTQGADLSPDEKVL------SKPPEGVVSEVEM 502
D EP +P + + E E P AD PD S+PP EV+
Sbjct: 1750 DPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDP 1809
Query: 503 LSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQK 562
+ + K S K + K K D E + + P E K
Sbjct: 1810 PVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELK 1869
Query: 563 GE----------SSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWAS 612
E +SA+ E PE L+ ++ AT + R V
Sbjct: 1870 MEAEKITRTASKNSAADLEHPEP----SLPLSRTRRRNVRSVYATMGDHENRSPV----- 1920
Query: 613 FKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP-KPEEPKR 671
K+ V +P + K E + ++A + +T + + EE + +EP
Sbjct: 1921 -------KEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAE 1973
Query: 672 KVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDK---ETGTD-G 727
+ W R+ R + GGP+ G ++ +A + + E G G
Sbjct: 1974 TLKPPEGW-----------RSPRSQKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIG 2022
Query: 728 ILAGSQEHDPGQGSSSPEQ------AGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSE 781
+ S E + + EQ AG+ + E ++ P K SKSK
Sbjct: 2023 VKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRN 2082
Query: 782 DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDS 841
+A K S ++ + P G QA ++G + + S
Sbjct: 2083 SRLA------------VDKSASLKNVDAAV------SPRGAAAQAGERESGVVAVSPEKS 2124
Query: 842 DVP----AVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVA 897
+ P + + D V+ +K E ++ SA P + AT+++K++ Q A +A
Sbjct: 2125 ESPQKEDGLSSQLKSDPVDPDK-EPEKEDVSASGPSPE-ATQLAKQMELEQAVEHIAKLA 2182
Query: 898 DGTRAATIIEERSPSWISASVTEPLEQV-EAEAALLTEEVLEREVIAEEEPPTVTEPLPE 956
+ + +A + +P Q E E A ++ ++ E E P P
Sbjct: 2183 EASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSII-NDISGEPENFPAPPPYPG 2241
Query: 957 NREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTT 1016
S+ +L P A A G E S ET + ++PD +
Sbjct: 2242 E---------SQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPS 2292
Query: 1017 EEATPVQEVEGGVPDIEE---QERRTQEVLQAVAEKVKEESQLPGT----GGPEDVLQPV 1069
T +E G + + + ++EV + K K + + + V+ PV
Sbjct: 2293 AGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPV 2352
Query: 1070 QRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPES----FEKAPQ 1125
+ E + Q E+ + T V QE K Q + T P+S K P
Sbjct: 2353 ESHVPESNQAQGESPAANEGTTVQHPEAPQEEK-----QSEKPHSTPPQSCTSDLSKIPS 2407
Query: 1126 VTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADF--DAP 1183
S S E+ + T A V +PP P D E V P
Sbjct: 2408 TENS--SQEISVEERTPTKASVPPD-------LPPPPQPAPVDEEPQARFRVHSIIESDP 2458
Query: 1184 GTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL 1243
T D + I V + S + +P Q QEE + QS L
Sbjct: 2459 VTPPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPAL 2518
Query: 1244 EHTDKEVSVETVS 1256
K V+T S
Sbjct: 2519 PPDTKASDVDTSS 2531
Score = 82.0 bits (201), Expect = 5e-15
Identities = 238/1237 (19%), Positives = 437/1237 (35%), Gaps = 263/1237 (21%)
Query: 10 RSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVA 69
++PE PE + + PS G PS + + A L+K T+
Sbjct: 1618 KTPESAPENKDSELKTPPSVGPPSV----------TVVTLESAPSALEKTTGDKTVEAPL 1667
Query: 70 EQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSK-RDSDKEMATKS 128
+E +++ ++ + ++ E V Q + D+ D DKE A
Sbjct: 1668 VTEEKTVEPATVSEE-----------AKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMP 1716
Query: 129 AVVHDITDDGQ-----EETPEIIEQIPSSESNLE---ELTQPTESQANDIGFKKVFKFVG 180
A V + + Q + P +ESN++ + TQP A
Sbjct: 1717 AGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQK----------- 1765
Query: 181 FKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGE----AASKESEPKQS- 235
+ K EKPD + D + A A + + P+ E A+K+ +P +S
Sbjct: 1766 -SEEANEPKAEKPDAT--ADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSK 1822
Query: 236 -------------TEKP----EETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPS 278
EKP E + RE+ SP E+ Q + E K E E+
Sbjct: 1823 RSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEA-QKLLELKMEAEKITRTASK 1881
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE---ASEKKKEQEPEKV 335
SA P S S ++ + R P ++ VE + K+ E+E ++
Sbjct: 1882 NSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEA 1941
Query: 336 ----DTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGP 391
T G+ + E+ +EPAE+ P E P ++ + GP
Sbjct: 1942 AAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPP------EGWRSPRSQKTAAGGGP 1995
Query: 392 SEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVE-- 449
+K + K++ + E EV + + + EE AGS + +
Sbjct: 1996 QGKKGKN------EPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAG 2049
Query: 450 MDAEPQEAEPAKELVKL---KETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQ 506
D P E P + + K ++ S ++ + L+ D+ K + VS
Sbjct: 2050 TDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSP------- 2102
Query: 507 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 566
+G+ + +G+ +S +K + + +E G +Q+ +D D +E + E
Sbjct: 2103 -----RGAAAQAGERESGVVAVSPEKSESPQ----KEDGLSSQLKSDPVDPDKEPEKEDV 2153
Query: 567 ASSPEEPEEITC-----LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKK 621
++S PE LE+ + + + EA A + EG+ P +
Sbjct: 2154 SASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAYKADAP-EGLAP-----------E 2201
Query: 622 RVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEA 681
+P+ E EL +A + S + S E P P E + + +A
Sbjct: 2202 DRDKPAHQASETEL----AAAIGSIINDISGEPENF--PAPPPYPGESQTDLQPPAGAQA 2255
Query: 682 LICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGS 741
L + E G + + GIL + + S
Sbjct: 2256 L------------------------------QPSEEGMETDEAVSGIL---ETEAATESS 2282
Query: 742 SSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKE 801
P A P+ G T K+++ E S HS P+ + G +
Sbjct: 2283 RPPVNAPDPSAGP------------TDTKEARGNSSETS----------HSVPEAK-GSK 2319
Query: 802 ESWVSIKKFIPGR------RKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAV 855
E V++ + GR R+KR K+ APVE P +N+ + PA +E V
Sbjct: 2320 EVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPE-SNQAQGESPAA---NEGTTV 2375
Query: 856 EREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS 915
+ EA Q +K +E+P + +LS+ + + +EER+P+
Sbjct: 2376 QHP--EAPQEEKQSEKPHSTPPQSCTSDLSK-------IPSTENSSQEISVEERTPT--K 2424
Query: 916 ASVTEPLE--------QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVS 967
ASV L E +A ++E + + P++ P+P
Sbjct: 2425 ASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSDPSI--PIP------------ 2470
Query: 968 EAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEG 1027
T +VTAA+ + P+ + S + TE ++ + P +P +
Sbjct: 2471 ----TLPSVTAAKLSPPVASGGIPHQSPPTKVTEWITR----QEEPRAQSTPSPALPPDT 2522
Query: 1028 GVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRA-----------EAER 1076
D++ +++L + K + + T + +PV A ++++
Sbjct: 2523 KASDVDTSSSTLRKIL--MDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKK 2580
Query: 1077 PEEQAEASGLKKETDV---VLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESS 1133
P E+ A + +++ + V A + K P K+ S V+ +E+S
Sbjct: 2581 PLEEKTAPPVTNNSEIQASEVLVAADKEKVAPVIAPKIT------SVISRMPVSIDLENS 2634
Query: 1134 ELVTTCQ--AETLAGVKS--QEMVMEQAIPPDSVETP 1166
+ +T + +TL G+ S +V +P ++++ P
Sbjct: 2635 QKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGP 2671
Score = 71.2 bits (173), Expect = 8e-12
Identities = 359/1871 (19%), Positives = 657/1871 (35%), Gaps = 297/1871 (15%)
Query: 95 NSQEEEEVIVTEVGQRDSEDV-----SKRDSDKE---MATKSAVVHDITDDGQEETPEII 146
N E+++ QR+ E S RD D E + + VH +P
Sbjct: 685 NDPYEQDIREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQA 744
Query: 147 EQIPS-SESNLEELTQPTESQANDIG---FKKVFKFVGFKFTVKKDKTEKPDT------- 195
E++PS SE L + + + ++K+ K ++T K +KT+K T
Sbjct: 745 ERLPSDSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYT-KNEKTDKERTFDPERVE 803
Query: 196 -----VQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHA 250
++ V+KD+ + G PS + E +E+E +QS EKP K + A
Sbjct: 804 RERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSET-DQENEREQSPEKPRSCNKLSREKA 862
Query: 251 EISPPAESGQAVEEC------KEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGW 304
+ A++ + C KE+ + + P + ++ T ++ + +K
Sbjct: 863 DKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQVSQT 922
Query: 305 AGWRKKTS------FRKPKE----DEVEASEKK---KEQEPEKVDTEEDGKAEVASEKLT 351
+ S + PKE VE EK+ K ++ K + DG + V EKL
Sbjct: 923 EPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLE 982
Query: 352 ASEQ--------AHPQEPAESAHEPRLS----AEYEKVELPSEEQVSGSQGPSEEKPAPL 399
A ++ A Q+P P + ++ ++ S E + +G +E KP +
Sbjct: 983 ARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREGEAERKP--V 1040
Query: 400 ATEVF---DEKIEVHQEEVVAE---------VHVSTVEERTEEQKTEVEETAG-SVPAEE 446
E+ +KI++ + VA + V + + + + + E AG SV +E
Sbjct: 1041 RKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVENQE 1100
Query: 447 LVEMDAEPQEAE-----------PAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEG 495
+ P + + P +E V+ + E P + + V ++ G
Sbjct: 1101 VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIG 1160
Query: 496 VVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKG----KRGGGDEESGEHTQ-V 550
+ +++ S + Q +++ + G +K +R E G+ Q V
Sbjct: 1161 I--DIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKPPQDV 1218
Query: 551 PADSPDSQEEQ----------KGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDG 600
DSP S++++ K E + S + E + G V+ G E G
Sbjct: 1219 TDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRH-GSFHEDEDPIG 1277
Query: 601 EKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSS-TESTASEMQEEMKG 659
+ V + V P + ES K + D + ++ + S + E +
Sbjct: 1278 SPRLLSVKGSPKVDEKVLPYSNITVREESLKFNPYDSSRREQMADMAKIKLSVLNSEDEL 1337
Query: 660 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRG-------SSSDEEGGPKAMGGDHQ 712
+ + + ++ + D S ++I S +KR+ R S SDE+G K+
Sbjct: 1338 NRWDSQMKQDAGRFDVSFP-NSIIKRDSLRKRSVRDLEPGEVPSDSDEDGEHKSHSPRAS 1396
Query: 713 KADEAGK---------DKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFK 763
E+ + DK D L+ S E + + + T+ + E K
Sbjct: 1397 ALYESSRLSFLLRDREDKLRERDERLSSSLERNKFYSFALDKTITPDTK----ALLERAK 1452
Query: 764 RLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQ 823
L + R+++ S L+ S + + + D+ P SW KK I + + D K+
Sbjct: 1453 SLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKK 1512
Query: 824 EQAPVED--------------------------------------------AGPTGANE- 838
E E+ GAN
Sbjct: 1513 EDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANST 1572
Query: 839 -DDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATE----VSKELSESQVHMMA 893
D P V+ S + + R + + ++ + ++ E++ TE + E++ +
Sbjct: 1573 TDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELK 1632
Query: 894 AAVADGTRAATIIE-ERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTE 952
+ G + T++ E +PS + + + EA L+TEE EE +E
Sbjct: 1633 TPPSVGPPSVTVVTLESAPSALEKTTGDK----TVEAPLVTEEKTVEPATVSEEAKPASE 1688
Query: 953 PLPENREARGDTVVSEAELTPEAVTAAETA-GPLGAEEGT--------EASAAEETTEMV 1003
P P E + + +L P A E A P G EEG+ +A
Sbjct: 1689 PAPAPVEQ-----LEQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFS 1743
Query: 1004 SAVSQLTDSPDTTEE-ATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVK--EESQLPGTG 1060
A S + PD+T+ + P Q+ E E+ T + +K + ESQ P +
Sbjct: 1744 QAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASE 1803
Query: 1061 GPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESF 1120
E + P A+ ++P + + + V + K+E + K+ +P
Sbjct: 1804 DLE--VDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRG- 1860
Query: 1121 EKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVET-------PTDSETDG 1173
E + +E+ ++ T + A ++ E ++P T + +
Sbjct: 1861 EAQKLLELKMEAEKITRTASKNSAADLEHP----EPSLPLSRTRRRNVRSVYATMGDHEN 1916
Query: 1174 STPVAD-FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPA--QKERPPAPSSFVFQ 1230
+PV + + P T+K E E+ EA AVP ++ RPP +
Sbjct: 1917 RSPVKEPVEQPRVTRK------RLEREL--------QEAAAVPTTPRRGRPPKTRRRADE 1962
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGL--EGSI 1288
EE E + +TL+ + S +++ T +K K+ P + E +
Sbjct: 1963 EEENEAKEPAETLKPPEGWRS-------PRSQKTAAGGGPQGKKGKNEPKVDATRPEATT 2015
Query: 1289 DTG--ITVSREKVTEVALKGE-GTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREK 1345
+ G I V + A + E G+E+ +KD + K+PP V+V +K
Sbjct: 2016 EVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTD-----KNPPETAP----VEVVEKK 2066
Query: 1346 TEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVP----IIDGAKEVSSLEGSPPPCLG 1401
E ++ + + V + S + + P G +E + SP
Sbjct: 2067 PAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSES 2126
Query: 1402 QEEAVCTKIQVQSSEASFTLTAAAEEEKVLGET--ANILETGETLEPAGAHLVLEEKSSE 1459
++ Q++S E+ G + A L LE A H+ ++S
Sbjct: 2127 PQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEAS- 2185
Query: 1460 KNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQV 1519
+ + A E P D A A + +D+ GE E
Sbjct: 2186 ASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGE------------PENF 2233
Query: 1520 ACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQ 1579
+ DL+P G L+ ++ + T+E + +L +E T+
Sbjct: 2234 PAPPPYPGESQTDLQPPAGAQALQPS-------------EEGMETDEAVSGILETEAATE 2280
Query: 1580 AH--VIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAV----GQAHSDISKD 1633
+ + A AG KE + P +E E T V G+ + S+
Sbjct: 2281 SSRPPVNAPDPSAGPTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRR 2340
Query: 1634 MSEASEKTMT-VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSL 1692
++K + VE N Q E P+ EG P+++ ++ EK
Sbjct: 2341 KRNTNKKVVAPVESHVPESNQAQGES---PAANEGTTVQHPEAPQEE------KQSEKPH 2391
Query: 1693 VEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVH 1752
P + D P +NS+ + TK S + P + E +VH
Sbjct: 2392 STPPQSCTSDLSKIPSTENSSQEISVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVH 2451
Query: 1753 S--ESDKAITP 1761
S ESD P
Sbjct: 2452 SIIESDPVTPP 2462
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 87.0 bits (214), Expect = 1e-16
Identities = 129/615 (20%), Positives = 231/615 (37%), Gaps = 66/615 (10%)
Query: 310 KTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR 369
+ S R +E + + + +EP+ + E +AE+ + T + H
Sbjct: 449 RCSERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSS-TVESLGETTDILNMTHIMS 507
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD----EKIEVHQEEVVAEVHVS--- 422
L++ + ++L ++ Q E TE D E++ +E + HVS
Sbjct: 508 LNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGI 567
Query: 423 -------TVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKL-----KETC 470
T+E ++E+ EE G AE+ E QE E +E VK+ ++T
Sbjct: 568 FMTQPATTIEAFSDEEVEIPEEKEG---AEDSKGNGIEEQEVEANEENVKVHGGRKEKTE 624
Query: 471 VSGEDPTQGADLSPDE-KVLSKPPEGVV-----------SEVEMLSSQERMKVQGSPLKK 518
+ +D T A++S + K + + +G S E +ER K + +
Sbjct: 625 ILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRG 684
Query: 519 LFT--STGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEI 576
G K+L+ K++ KR G ++E E Q + + E+ GE EE E
Sbjct: 685 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEG- 743
Query: 577 TCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELD 636
D E EE +G+++ EG +K +K+ R + +K +E
Sbjct: 744 ------------DREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG 791
Query: 637 KVKSATLSSTESTASEMQEEMK---GSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRAR 693
TE E +E + G VEE K E + + + G ++
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE-----------GEGEEEEG 840
Query: 694 RGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEG 753
G + EG + G ++ E G+ +E G +G G +E G+G E G EG
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
Query: 754 EGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPG 813
EG E ++ + K EE+ E+ E + E G+ E ++
Sbjct: 901 EGEGEEEGEGE--GEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958
Query: 814 RRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPE 873
+ +G++E + G E++ + E + E + E + + E+ E
Sbjct: 959 EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE 1018
Query: 874 QKAATEVSKELSESQ 888
+ EV E E +
Sbjct: 1019 GEVEGEVEGEEGEGE 1033
Score = 87.0 bits (214), Expect = 1e-16
Identities = 139/598 (23%), Positives = 237/598 (39%), Gaps = 84/598 (14%)
Query: 96 SQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESN 155
S EE E+ + G DS+ + + E ++ VH G++E EI+ +
Sbjct: 580 SDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHG----GRKEKTEILSD------D 629
Query: 156 LEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDH 215
L + + +E +A +G + T ++ + ++++GE G G+
Sbjct: 630 LTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSS---GAEHWQDEEREKGEKDKGRGEM 686
Query: 216 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 274
+ P G E A KE K+ E+ E+ +REQ H + E Q +EE +EE E +E
Sbjct: 687 ERPGEGEKELAEKEEWKKRDGEEQEQK-EREQGHQK-----ERNQEMEEGGEEEHGEGEE 740
Query: 275 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQ---- 330
+E + E E G + G R+K + KE+ EK +E+
Sbjct: 741 EEGDREEEEEKEGEGKEEGE------GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQG 794
Query: 331 EPEKVDT-------EEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEE 383
E E+ +T EE G+ E + E+ +E E E E E E E
Sbjct: 795 EGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE-----EGEGEEEEGEG 849
Query: 384 QVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVP 443
+ +G EE+ E E+ E EE E E EE + E EE G
Sbjct: 850 EEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE------GEGEEEGEGEGEEEEGEGE 903
Query: 444 AEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEML 503
EE E + E +E E E E+ +G +E+ + +G E
Sbjct: 904 GEEEGEGEGEEEEGEGKGE-----------EEGEEGEGEGEEEEGEGEGEDGEGEGEEEE 952
Query: 504 SSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKG 563
E + +G G ++ G+ ++G+ G G+EE GE + + + E++G
Sbjct: 953 GEWEGEEEEGE-------GEGEEEGEGEGEEGE-GEGEEEEGE-----GEGEEEEGEEEG 999
Query: 564 ESSASSPEEPEEITCLEKGLAEVQQDGEAE---EGATSDGEKKREGVTPWASFKKMVTPK 620
E EE E G E +++GE E EG +GE + E ++
Sbjct: 1000 EEEGEGEEEGE-------GEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052
Query: 621 KRVRRPSESDKEDELDKVKSATLSSTESTASEMQE--EMKGSVEEPKPEEPKRKVDTS 676
+ RR E ++E+E ++ + E ++ ++KGSV+ K + ++K T+
Sbjct: 1053 EENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTN 1110
Score = 70.5 bits (171), Expect = 1e-11
Identities = 139/690 (20%), Positives = 249/690 (36%), Gaps = 121/690 (17%)
Query: 227 SKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTS 286
S S K P + K++Q+ E++ ++ + +E EE E + K+
Sbjct: 507 SLNSNEKSLKLSPVQKQKKQQTIGELTQ--DTALTENDDSDEYEEMSEMKEGKAC----- 559
Query: 287 PVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKK-----------KEQEPE-- 333
K+ +QG + T+ ++EVE E+K +EQE E
Sbjct: 560 ----------KQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEAN 609
Query: 334 ----KVDTEEDGKAEVASEKLT-----ASEQAHPQEPAESAHEPRLSAEYEKVELPSE-- 382
KV K E+ S+ LT + +A AE E R E+ +E
Sbjct: 610 EENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHW 669
Query: 383 -----EQVSGSQGPSE-EKPAPLATEVFDE---KIEVHQEEVVAEVHVSTVEERTEEQKT 433
E+ +G E E+P E+ ++ K +E+ E +ER +E +
Sbjct: 670 QDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEE 729
Query: 434 EVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPP 493
EE G EE + E +E E G++ +G ++ + +
Sbjct: 730 GGEEEHGEGEEEEGDREEEEEKEGE--------------GKEEGEGEEVEGER----EKE 771
Query: 494 EGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPAD 553
EG + E +E+ + +G G ++ + + + K GG+ E GE + +
Sbjct: 772 EGERKKEERAGKEEKGEEEGD------QGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGE 825
Query: 554 SPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASF 613
+ +EE +GE EE E E+G + +++GE EG E + EG
Sbjct: 826 REEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEG------- 878
Query: 614 KKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKV 673
++ E + E E ++ + E +EE +G EE E
Sbjct: 879 -----EEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGE---- 929
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
G ++ G D EG G+ ++ + G+++E +G G
Sbjct: 930 ------------GEGEEEEGEGEGEDGEG-----EGEEEEGEWEGEEEEGEGEGEEEGEG 972
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG--SGVEH 791
E + G+G E+ EGE E + ++ + + EE+ E + G G E
Sbjct: 973 EGEEGEGEGEEEEGEG--EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEG 1030
Query: 792 STPDTEPGKEESWVSIKKFIPG--RRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
E EE +K G R+ R + ++E+ ++ G D +
Sbjct: 1031 EGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGE------- 1083
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATE 879
EY V + K + + Q + T+
Sbjct: 1084 -EYKKVSKIKGSVKYGKHKTYQKKSVTNTQ 1112
Score = 56.6 bits (135), Expect = 2e-07
Identities = 149/749 (19%), Positives = 255/749 (34%), Gaps = 114/749 (15%)
Query: 558 QEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMV 617
QE E PEEP+ + L E+ ++ E + +T + + + +
Sbjct: 456 QESVLSEQDLMQPEEPDYL------LDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLN 509
Query: 618 TPKKRVR-RPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKP---------- 666
+ +K ++ P + K+ + + + TE+ S+ EEM ++E K
Sbjct: 510 SNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMS-EMKEGKACKQHVSQGIF 568
Query: 667 -EEPKRKVDTSVSWEALICVGSSKKRARRGSSSDE------EGGPKAMGGDHQKADEAGK 719
+P ++ E I +G+ +E E K GG +K +
Sbjct: 569 MTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSD 628
Query: 720 DKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST---WESFKRLVTPRKKSKSKL 776
D + ++ + G+ PE G T EG S W+ +R + K + ++
Sbjct: 629 DLTDKAE--VSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEM 686
Query: 777 EEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGA 836
E E + E ++E W KKR +QEQ E
Sbjct: 687 ERPGEG------------EKELAEKEEW-----------KKRDGEEQEQKEREQGHQKER 723
Query: 837 NED-DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAA 895
N++ + E + +RE+ E ++ + E ++ E KE E + A
Sbjct: 724 NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGK 783
Query: 896 VADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLP 955
G E E E E E + E ERE EE E
Sbjct: 784 EEKGEEEGDQGEGEEEE-TEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEG 842
Query: 956 ENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDT 1015
E E G+ E + G EEG E EE E + +
Sbjct: 843 EEEEGEGEEEEGEGK---------------GEEEGEEGEGEEEGEEGEGEGEEEEGEGEG 887
Query: 1016 TEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE 1075
EE E E G + EE+ E + + +E + G G E+ + E E
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGE 947
Query: 1076 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKV-VGQTTPESFEKAPQVTESIESSE 1134
EE+ E G ++E + E + E +G+ G+ E E + E E E
Sbjct: 948 GEEEEGEWEGEEEEGE-------GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000
Query: 1135 LVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEI 1194
E G + E E + E + E +G + G +++E E
Sbjct: 1001 -------EEGEGEEEGEGEGE-----EEEEGEVEGEVEGE------EGEGEGEEEEGEEE 1042
Query: 1195 HEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVET 1254
EE E E E ++ R +EE +E+ K ++T E ++ E
Sbjct: 1043 GEERE---------KEGEGEENRRNR---------EEEEEEEGKYQETGEEENERQDGEE 1084
Query: 1255 VSILSKTEGTQEADQYADEKTKDVPFFEG 1283
+SK +G+ + ++ + K V +G
Sbjct: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQG 1113
Score = 53.1 bits (126), Expect = 2e-06
Identities = 74/371 (19%), Positives = 134/371 (36%), Gaps = 67/371 (18%)
Query: 8 EQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKN-GQLSTIN 66
E++ E+ +G E E G G E + + ++ G+
Sbjct: 784 EEKGEEEGDQGEGE--EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE 841
Query: 67 GVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMAT 126
G E+ E +EG+ G++ G+G +E E E G+ + E+ + + ++E
Sbjct: 842 GEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG- 900
Query: 127 KSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVK 186
+ + +G+EE E + E E + E + D
Sbjct: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGED----------------G 944
Query: 187 KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKRE 246
+ + E+ + + EGE G G+ ++ G GE E E ++ + EE E
Sbjct: 945 EGEGEEEE-------GEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEE 997
Query: 247 QSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAG 306
+ E G+ EE + EGEE++E E E
Sbjct: 998 EGE-------EEGEGEEEGEGEGEEEEEGEVEGEVEG----------------------- 1027
Query: 307 WRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAH 366
+E E E E++ E+E E+ + E +G+ + + E+ QE E +
Sbjct: 1028 ----------EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEEN 1077
Query: 367 EPRLSAEYEKV 377
E + EY+KV
Sbjct: 1078 ERQDGEEYKKV 1088
Score = 52.4 bits (124), Expect = 4e-06
Identities = 129/647 (19%), Positives = 229/647 (35%), Gaps = 60/647 (9%)
Query: 1149 SQEMVMEQAIPPDSVETPTDSE--TDGSTPVADFDAPGTTQK-DEIVEIHEENEVASGTQ 1205
S+ + E + + P + + D T A+ D T + E +I + S
Sbjct: 451 SERNLQESVLSEQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMS-LN 509
Query: 1206 SGGTEAEAVPAQKERPPAPSSFVFQE----ETKEQSKMEDTLEHTDKEVSVETVSI-LSK 1260
S + P QK++ + Q+ E + + E+ E + + + VS +
Sbjct: 510 SNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFM 569
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG--TEEAECKKDD 1318
T+ + ++DE+ + EG E S GI + E +K G E+ E DD
Sbjct: 570 TQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDD 629
Query: 1319 ALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV 1378
+ ++ V R E E + E ++ + ++
Sbjct: 630 LTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERP 689
Query: 1379 NVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANIL 1438
+G KE++ E G+E+ + Q E + + EEE GE
Sbjct: 690 G----EGEKELAEKEEWKKRD-GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEE---- 740
Query: 1439 ETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSS 1498
E G+ E EEK E E+ GE+ + + + +KG
Sbjct: 741 EEGDREEE-------EEKEGEGKEE---GEGEEVEGEREKEEGERKKEERAGKEEKGEEE 790
Query: 1499 DLEGE---KTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQ 1555
+GE + T + + E +V EV+ + E E G E E +
Sbjct: 791 GDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE------- 843
Query: 1556 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1615
EE E E + + + + ++ G+E E EGEE + + E
Sbjct: 844 --------EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEG 895
Query: 1616 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSV 1675
EE E G+ + + E K E EG + EE E+G G G +
Sbjct: 896 EEEEGEGEGEEEGEGEGEEEEGEGKG---EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEE 952
Query: 1676 PEDDGHALLAERIEKSLVEPK----EDEKGDDVDDPENQNSALADTDASGGLTKESPDTN 1731
E +G E + E + E E ++ + E + + G +E +
Sbjct: 953 GEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGE 1012
Query: 1732 GPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
G +++E E EVE +EG+ E + + +EE +++E+E E
Sbjct: 1013 GEEEEEGEVEGEVEGEEGEGEGEEE-----EGEEEGEEREKEGEGEE 1054
Score = 50.1 bits (118), Expect = 2e-05
Identities = 127/605 (20%), Positives = 211/605 (34%), Gaps = 101/605 (16%)
Query: 1183 PGTTQK---DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEE--TKEQS 1237
P TT + DE VEI EE E A ++ G E + V A +E + E + + +
Sbjct: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
Query: 1238 KMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSRE 1297
+ E K V + +GT E E +D E +G D G
Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDE---EREKGEKDKGRG---- 684
Query: 1298 KVTEVALKGEG----TEEAECKKDDALELQSHAKSPPSPVER--EMVVQVEREKTEAEPT 1351
E+ GEG E+ E KK D E + + ER EM E E E E
Sbjct: 685 ---EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEE 741
Query: 1352 HVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQ 1411
+ E+ E + E ++ ++G +E E G+EE + +
Sbjct: 742 EGDREEEEEKEGEGKEEGEGEE---------VEGEREKEEGERKKEERAGKEEK--GEEE 790
Query: 1412 VQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGED 1471
E T EEK E +E GE +EE E+ E+ GE+
Sbjct: 791 GDQGEGEEEETEGRGEEK---EEGGEVEGGE----------VEEGKGEREEEEEEGEGEE 837
Query: 1472 AVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE 1531
G + ++G + EGE + + E +E+ E
Sbjct: 838 EEGEGEE--------------EEGEGEEEEGEGKGEEEGEEGEGEEEG-----------E 872
Query: 1532 DLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAG 1591
+ E E E E + + + + + EE E + + + ++ G
Sbjct: 873 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE-------GEGEGEEEEGEGKGEEEG 925
Query: 1592 QETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTV 1651
+E E EGEE + + E +EE G+ + + E E+ E EG
Sbjct: 926 EEGEGEGEEEEGEGEGEDGEGEGEEEE-----GEWEGEEEEGEGEGEEEG---EGEG--- 974
Query: 1652 NDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQN 1711
EEG G G + E +G E + E +E+ +G+ ++ E +
Sbjct: 975 -------------EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEV 1021
Query: 1712 SALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQE 1771
+ + G +E +++EKE E + + E + +EE ++Q+
Sbjct: 1022 EGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQD 1081
Query: 1772 RESAK 1776
E K
Sbjct: 1082 GEEYK 1086
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 87.0 bits (214), Expect = 1e-16
Identities = 302/1563 (19%), Positives = 543/1563 (34%), Gaps = 262/1563 (16%)
Query: 307 WRKKTSF-RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESA 365
W++ + RK K +E A + KK + + + T E + E +E TA +A P+ S
Sbjct: 53 WQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETA--KATPR--LAST 108
Query: 366 HEPRLSAEYE---KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 422
+ L A+ K + +E + +G G S PA T + ++ + +
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 423 TVEERTEE------------------QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV 464
V E EE Q E S E VE + A+ V
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 465 KLKETCVSGEDPTQG--ADLSPDEKVLSKPP---------------EGVVSEVEM-LSSQ 506
KE+ P G D++P K + PP EG SE E ++
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
Query: 507 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 566
++K L+ S K GK G G+ V + + + E+ ESS
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGK------GATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 567 ASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGVTPWASFKKMVTPKKRV 623
+ + EE T K L + + G+ + GA S K+ R+G P K K
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402
Query: 624 RRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE--- 680
E D + ++ S + ++ S +++ + P E P++ + +
Sbjct: 403 AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKESPRKGAAPAPPRKTGP 461
Query: 681 --ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPG 738
A + VG ++ +R S + + + GK + + G G
Sbjct: 462 AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM-GMGPLGKG 520
Query: 739 QGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT-E 797
G P + G T V WE + S+S EE S+ S + P
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDSS------DGEVPTAVA 565
Query: 798 PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVER 857
P +E+S +I + +P + P + AGP V A P+ ++ E
Sbjct: 566 PAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ-----VKAEKPMDNSESSEE 613
Query: 858 EK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATII 906
M A QA+ + + P+ KA + + + ++V + +A T
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 907 EERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 966
SP+ S +V ++ +++ E +EEE + + + + V
Sbjct: 674 ---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 967 SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 1026
A + + TA L + G T V A Q + +++EE + +E
Sbjct: 725 KAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ--EDSESSEEESDSEEAA 775
Query: 1027 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPVQRAEAERPEEQAEASG 1085
++ ++TQ A + GT P V+ +A+ P +
Sbjct: 776 ASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 1086 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLA 1145
+ + V+ + A QT PE E + E +S E +AETLA
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEESDSEE-----EAETLA 885
Query: 1146 GVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1203
VK + A+ P +S G+ P PG T +++ +S
Sbjct: 886 QVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTGPSAAQAGKQDDSGSSS 936
Query: 1204 TQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+S G A AQ +PP +F + + + T + T
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPAQAQ---AASTPRKARA 989
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
+E T + E +P + L I T + +A K + K+ +
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1380
+ +K E T V ++AV S Q
Sbjct: 1050 S--------------------DGKKQEGPATQV-------DSAVGTLPATSPQSTSVQ-- 1080
Query: 1381 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILET 1440
AK + L P + ++A SE S ++ +EE+ GE ++
Sbjct: 1081 -----AKGTNKLRKPKLPEV--QQATKAPESSDDSEDSSDSSSGSEED---GEGPQGAKS 1130
Query: 1441 GETL--EPAGAHLVLEEKSSEKNEDFAAHPGEDAVP-------TGPDCQA-KSTPVIVSA 1490
TL P+ ++EE ++E +ED P + + T + QA K+TP + S+
Sbjct: 1131 AHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSS 1190
Query: 1491 ---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE-DLEPENGILELETKS 1546
++ D +G++ + + + + +E + +P+ G + +
Sbjct: 1191 PSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAST 1250
Query: 1547 SKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQ 1606
L NI Q + Q +E Q QA V+K ++ QE +K + + S++
Sbjct: 1251 LALQSNITQCLLGQ---------PWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSR 1301
Query: 1607 DETPITSAKEESESTAVGQAHSDISKDMS-----EAS---EKTMTVEVEGSTVNDQQLEE 1658
K + A S K + EAS EKT T +G D+ +
Sbjct: 1302 KGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTS-KGKAKRDKASGD 1360
Query: 1659 VVLPSEEEGGGA----GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSAL 1714
V E++G G+ G K PE E ++K + +G D +P+++
Sbjct: 1361 V---KEKKGKGSLGSQGAKDEPE--------EELQKGM----GTVEGGDQSNPKSK---- 1401
Query: 1715 ADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERES 1774
K+K+K D ++ + ++ + ++ KA T ++ QK++++
Sbjct: 1402 -------------------KEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKKK 1442
Query: 1775 AKS 1777
K+
Sbjct: 1443 KKT 1445
Score = 80.9 bits (198), Expect = 1e-14
Identities = 242/1223 (19%), Positives = 414/1223 (33%), Gaps = 210/1223 (17%)
Query: 186 KKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPS-----LGAGEAASKESEPKQSTEKPE 240
KK + P + + +++E E + S LGA +S + + K TEK
Sbjct: 74 KKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAG 133
Query: 241 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 300
+T P +G+ V ++ EPS A + T E GS F
Sbjct: 134 KT-------GNSMPHPATGKTVANLLSGKSPRKSAEPS--ANTTLVSETEEEGSV-PAFG 183
Query: 301 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 360
G ED +S+ +T+ +GK V ++ AS + +
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSD----------ETDVEGKPSVKPAQVKASSVSTKES 233
Query: 361 PAESAH---------EPRLSA----EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 407
PA A P++ ++ + P EE S +G E+ AP T +
Sbjct: 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGT-----R 288
Query: 408 IEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLK 467
+V E + +V ++ + K G A + ++ + +P ++
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA-----VASQTKAGKPEEDSESSS 343
Query: 468 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLS--SQERMKVQGSPLKKLFTSTGL 525
E E+ T A + +L G S+V S ++E + +P T +
Sbjct: 344 EESSDSEEETPAA-----KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398
Query: 526 KKLSGKKQKGKRGGGDEESGEHTQVPADS-PDSQEEQKGESSASSPEEPEEITC----LE 580
K K++ EES + PA + P + Q +SA + E P + +
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 581 KGLAEVQ-QDGEAEEGATSDGEKK---RE-------------------------GVTPWA 611
G A Q Q G+ EE + S E+ RE G+ P
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 612 SFKKMVTP-KKRVRRPS------ESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP 664
V P K PS E D E ++ ++ + + QE+ G++ +
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA 578
Query: 665 KPEE------PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK----- 713
KP P++ +V +A + +S+ S+D E P AM K
Sbjct: 579 KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 638
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
K+T T A ++ G+ +P +AG+ T G S + P + S
Sbjct: 639 PQTKACPKKTNT---TASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA-GGTQRPAEDSS 694
Query: 774 SKLEEKSEDSIAGSGVE-----------HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 822
S E SE+ G V + P K +PG K P
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG--KTGPTVT 752
Query: 823 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 882
Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 753 QVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGT----- 805
Query: 883 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ------------------ 924
+A AA ++RSPS + V P
Sbjct: 806 ----------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 925 VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTA 978
A+A EE E E +EEE T+ + P + + ++ A+ +P A T
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 979 AETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT---EEATP 1021
GP A+ G + S++EE+ A + +T + P+ + ATP
Sbjct: 916 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATP 975
Query: 1022 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTG------GPEDVLQPVQRAEAE 1075
Q P + R ++ ++ + + ++E +P T V P
Sbjct: 976 AQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 1076 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSEL 1135
A AS K+ + + + T+ + + T+P+S + T + +L
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 1136 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA------PGTTQK- 1188
QA T A S + DS ++ + SE DG P A P T+
Sbjct: 1093 PEVQQA-TKAPESSDD-------SEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETL 1144
Query: 1189 -DEIVEIHEENEVASGTQ---SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE 1244
+E E++V + +Q SG PA + A +D +
Sbjct: 1145 VEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPD 1204
Query: 1245 HTDKEVSVETVSILSKTEGTQEA 1267
+ + +LS G +EA
Sbjct: 1205 GKQEAKPQQAAGMLSPKTGGKEA 1227
Score = 65.9 bits (159), Expect = 3e-10
Identities = 273/1431 (19%), Positives = 471/1431 (32%), Gaps = 189/1431 (13%)
Query: 499 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 558
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 559 EEQKGESSASSPEEPE-------------EITCLEKGLAEVQQDGEAEEGATSDGEKKR- 604
EE++ + ++ P + EK AE ++ G+ K
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 605 EGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTEST--ASEMQEEMKGSVE 662
+ S +K P SE+++E + +A S A E+ S +
Sbjct: 149 ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSD 208
Query: 663 EPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 722
E E V ++ S ++A + P+ GG A A K +E
Sbjct: 209 ETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 723 TGTDGILAGSQEHDPGQGSSSPEQAGSP-------------TEGEGVSTWESFKRLVTPR 769
E + G+ S +A T G+G + K
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 770 KKSKSKLEEKSEDSI-AGSGVEHSTPDTE---PGKEESWVSIKKFIPGRRKKRPDGKQEQ 825
+ K EE SE S S E TP + K S K+ P
Sbjct: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 826 APVEDAGP------TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATE 879
AP GP G E+DS S + + E+ QA+ S + P+ +AA+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQ-------SSSEESDSEEEAPAQAKPSGKAPQVRAASA 441
Query: 880 VSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLER 939
+KE S + A G AA + + +S E EA AA+ +V
Sbjct: 442 PAKE-SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 940 EVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEA-VTAAETAGPLGAEEGTEASAAEE 998
+ +P + P + A TP A V E +EE +++S E
Sbjct: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV 560
Query: 999 TTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEES---- 1054
T + A + S +A P G P ++ +Q AEK + S
Sbjct: 561 PTAVAPAQEK---SLGNILQAKPTSSPAKGPP-----QKAGPVAVQVKAEKPMDNSESSE 612
Query: 1055 QLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQ 1114
+ + E+ + A+A+ + + K+T+ + K
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
Query: 1115 TTPESFEKA-----PQVTESIESSELVTTCQAET-LAGVKSQEMVMEQAIPPDSVETPT- 1167
T+P A + E SSE + + +T LA Q + + + + P
Sbjct: 673 TSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVK 732
Query: 1168 DSETDGSTPV-ADFDAPGTTQ-KDEIVEIHEENEVASGTQSGG------------TEAEA 1213
S G+ PV P TQ K E E E +E S ++ T+A+A
Sbjct: 733 GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA 792
Query: 1214 VPAQKERPPAPSSF---------VFQEETKEQSKMEDTLEHTDKEVSV----ETVSILSK 1260
PA P A + Q + + SK++ + + + +V + K
Sbjct: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGK 852
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG-TEEAECKKDDA 1319
T Q E+ GS + E T +K G T + A
Sbjct: 853 AVATAAQAQTGPEED---------SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 1320 LELQSHAKSPPSPVER-EMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV 1378
E +P P + Q ++ + ++ E AVT ++ + L+
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI--- 960
Query: 1379 NVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASF-TLTAAAEEEKVLGETANI 1437
+D + + +P Q +A T + ++SE++ + ++ +E+E V+ T +
Sbjct: 961 ---FVDPNRSPAGPAATP----AQAQAASTPRKARASESTARSSSSESEDEDVIPATQCL 1013
Query: 1438 -------LETGETLEP--------AGAHLVLEEK--SSEKNEDFAAHPGEDAVPTGPDCQ 1480
+ T T P AGA E S K ++ A + AV T P
Sbjct: 1014 TPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATS 1073
Query: 1481 AKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQ---------------------- 1518
+ST V T K E ++ T SD+ ++
Sbjct: 1074 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1133
Query: 1519 VACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT 1578
+ + +E+ E+ ++ S L+ + + AT L S
Sbjct: 1134 LGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSV 1193
Query: 1579 QAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQA------------ 1626
+ + D D QE +PQ +A +P T KE + T ++
Sbjct: 1194 SSTLAAKDDPDGKQEA-----KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQA 1248
Query: 1627 -----HSDISKDMSEASEKTMTVEVEGSTVN------DQQLEEVVLPSEEEG--GGAGTK 1673
S+I++ + +V+ S V +Q+ ++VV ++E G K
Sbjct: 1249 STLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRK 1308
Query: 1674 SVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNS---ALADTDASGGLTKESPDT 1730
D A R +K + E G+ PE ++ A D + G KE
Sbjct: 1309 RKLSGDQPAARTPRSKKK-KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGK 1367
Query: 1731 NGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTE 1781
+ +D E ELQ+G E P++++E +K ++ E E
Sbjct: 1368 GSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1418
Score = 60.8 bits (146), Expect = 1e-08
Identities = 248/1223 (20%), Positives = 417/1223 (34%), Gaps = 235/1223 (19%)
Query: 16 PEGSSTPAEPEPSG--------GGPSAEAAPDTTADPAIAASDPATKLL---QKNGQLST 64
P +TPA P +G G P ++ + PA K L + +G+ S
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 65 INGVAEQDELSLQEGDLN---GQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSK-RDS 120
+ + + S ++G G+ G + +EE+ +E + E ++ + S
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 121 DK--EMATKSAVVHDITDDGQEETP-----------EIIEQIPSSESNLEELTQPTESQA 167
K ++ SA + G P ++ +Q S S+ EE E+ A
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 490
Query: 168 NDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAG---- 223
K K + + T+ + + K G G PS G
Sbjct: 491 -------AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEE 543
Query: 224 --EAASKESEPKQSTEKPEETLKREQ------------SHAEISPPAESGQAVEECKEE- 268
E++S+ES E P ++ S PP ++G + K E
Sbjct: 544 DSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK 603
Query: 269 --GEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK 326
+ +E S SA+S +P Q + + PK+ AS K
Sbjct: 604 PMDNSESSEESSDSADSEEAPAAMTAA--------QAKPALKIPQTKACPKKTNTTASAK 655
Query: 327 KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVS 386
P +V T+ KA A+ +S PA + R P+E+ S
Sbjct: 656 VA---PVRVGTQAPRKAGTATSPAGSS-------PAVAGGTQR----------PAEDSSS 695
Query: 387 GSQGPSEEKPAPLATEVFDEK-----IEVHQEEV-----VAEVHVSTVEERTEEQKTEV- 435
+ SEE+ LA V K ++V V + + + +T T+V
Sbjct: 696 SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVK 755
Query: 436 -EETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPE 494
E+ S +EE E D+E A PA+ +K+T A +P K P
Sbjct: 756 AEKQEDSESSEE--ESDSEEAAASPAQVKTSVKKTQAKANP---AAARAPSAKGTISAPG 810
Query: 495 GVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES-GEHTQVPAD 553
VV+ + KV+ P++ ST L RG S G+ A
Sbjct: 811 KVVTAAAQAKQRSPSKVK-PPVRNPQNSTVLA----------RGPASVPSVGKAVATAAQ 859
Query: 554 SPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE---GATSDGEKKREGVTPW 610
+ EE G S S E E T LA+V+ G+ + E R+G P
Sbjct: 860 AQTGPEEDSGSSEEESDSEEEAET-----LAQVKPSGKTHQIRAALAPAKESPRKGAAP- 913
Query: 611 ASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE--- 667
P K +++ K+D+ SS ES + S + KP
Sbjct: 914 ------TPPGKTGPSAAQAGKQDDSGS------SSEESDSDGEAPAAVTSAQVIKPPLIF 961
Query: 668 -EPKRKVDTSVSWEALICVGSSKKRAR------RGSSSDEEGG----------------- 703
+P R + A S+ ++AR R SSS+ E
Sbjct: 962 VDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 704 ---PKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSS-----PEQAGSPTEGEG 755
P A KA AG + I G ++ P S P + T +
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQA 1081
Query: 756 VSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRR 815
T ++ P + +K E S+DS + D+ G EE +
Sbjct: 1082 KGT-NKLRKPKLPEVQQATKAPESSDDS-------EDSSDSSSGSEEDGEG-PQGAKSAH 1132
Query: 816 KKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEY--DAVEREKMEAQQAQKSAEQPE 873
P + + VE+ ++EDD P+ LS Y + +A +A +
Sbjct: 1133 TLGPTPSRTETLVEETAAE-SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSP 1191
Query: 874 QKAATEVSK-------ELSESQVHMMAAAVADGTRAA---TIIEERSPSW---------- 913
++T +K E Q M + G AA T + R P
Sbjct: 1192 SVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTL 1251
Query: 914 -ISASVTEPL---------EQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGD 963
+ +++T+ L QV+A + E+LE+E ++ T E + E+R
Sbjct: 1252 ALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE--RKKVVDTTKESSRKGWESRKR 1309
Query: 964 TVVSE--AELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATP 1021
+ + A TP + + LGA EG EAS + E T TT +
Sbjct: 1310 KLSGDQPAARTPRSKKKKK----LGAGEGGEASVSPEKT-------------STTSKGKA 1352
Query: 1022 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQL-PGTGGPEDVLQPVQRAEAERPEEQ 1080
++ G D++E++ + Q ++ +EE Q GT D P + E ++ +++
Sbjct: 1353 KRDKASG--DVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1410
Query: 1081 AEASGLKKETDVVLKVDAQEAKT 1103
+ K++ K +++++
Sbjct: 1411 KKDKEKKEKKKKAKKASTKDSES 1433
Score = 35.4 bits (80), Expect = 0.50
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 216 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 274
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1325 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1384
Query: 275 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 334
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1385 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1428
Query: 335 VDTEEDGKAEVASEKLTASE 354
D+E + + +K TA +
Sbjct: 1429 KDSESPSQKKKKKKKKTAEQ 1448
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 86.7 bits (213), Expect = 2e-16
Identities = 302/1564 (19%), Positives = 543/1564 (34%), Gaps = 263/1564 (16%)
Query: 307 WRKKTSF-RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESA 365
W++ + RK K +E A + KK + + + T E + E +E TA +A P+ S
Sbjct: 53 WQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETA--KATPR--LAST 108
Query: 366 HEPRLSAEYE---KVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVS 422
+ L A+ K + +E + +G G S PA T + ++ + +
Sbjct: 109 NSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTT 168
Query: 423 TVEERTEE------------------QKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV 464
V E EE Q E S E VE + A+ V
Sbjct: 169 LVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV 228
Query: 465 KLKETCVSGEDPTQG--ADLSPDEKVLSKPP---------------EGVVSEVEM-LSSQ 506
KE+ P G D++P K + PP EG SE E ++
Sbjct: 229 STKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR 288
Query: 507 ERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESS 566
++K L+ S K GK G G+ V + + + E+ ESS
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGK------GATPAPPGKAGAVASQTKAGKPEEDSESS 342
Query: 567 ASSPEEPEEITCLEKGLAEVQQDGEAEE-GATSDGEKK--REGVTPWASFKKMVTPKKRV 623
+ + EE T K L + + G+ + GA S K+ R+G P K K
Sbjct: 343 SEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQ 402
Query: 624 RRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWE--- 680
E D + ++ S + ++ S +++ + P E P++ + +
Sbjct: 403 AGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA-SAPAKESPRKGAAPAPPRKTGP 461
Query: 681 --ALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPG 738
A + VG ++ +R S + + + GK + + G G
Sbjct: 462 AAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTM-GMGPLGKG 520
Query: 739 QGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT-E 797
G P + G T V WE + S+S EE S+ S + P
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWE---------EDSESSSEESSDSS------DGEVPTAVA 565
Query: 798 PGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVER 857
P +E+S +I + +P + P + AGP V A P+ ++ E
Sbjct: 566 PAQEKSLGNILQ-------AKPTSSPAKGPPQKAGPVAVQ-----VKAEKPMDNSESSEE 613
Query: 858 EK-----------MEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATII 906
M A QA+ + + P+ KA + + + ++V + +A T
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 907 EERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVV 966
SP+ S +V ++ +++ E +EEE + + + + V
Sbjct: 674 ---SPAGSSPAVAGGTQRPAEDSSS------SEESDSEEEKTGLAVTVGQAKSVGKGLQV 724
Query: 967 SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVE 1026
A + + TA L + G T V A Q + +++EE + +E
Sbjct: 725 KAASVPVKGSLGQGTAPVLPGKTGP-------TVTQVKAEKQ--EDSESSEEESDSEEAA 775
Query: 1027 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT-GGPEDVLQPVQRAEAERPEEQAEASG 1085
++ ++TQ A + GT P V+ +A+ P +
Sbjct: 776 ASPAQVKTSVKKTQAKANPAAARAPSAK---GTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 1086 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLA 1145
+ + V+ + A QT PE E + E +S E +AETLA
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPE--EDSGSSEEESDSEE-----EAETLA 885
Query: 1146 GVKSQEMV--MEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1203
VK + A+ P +S G+ P PG T +++ +S
Sbjct: 886 QVKPSGKTHQIRAALAPAK-----ESPRKGAAPTP----PGKTGPSAAQAGKQDDSGSSS 936
Query: 1204 TQS---GGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+S G A AQ +PP +F + + + T + T
Sbjct: 937 EESDSDGEAPAAVTSAQVIKPP----LIFVDPNRSPAGPAATPAQAQ---AASTPRKARA 989
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
+E T + E +P + L I T + +A K + K+ +
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNV 1380
+ +K E T V ++AV S Q
Sbjct: 1050 S--------------------DGKKQEGPATQV-------DSAVGTLPATSPQSTSVQ-- 1080
Query: 1381 PIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILET 1440
AK + L P + ++A SE S ++ +EE+ GE ++
Sbjct: 1081 -----AKGTNKLRKPKLPEV--QQATKAPESSDDSEDSSDSSSGSEED---GEGPQGAKS 1130
Query: 1441 GETL---EPAGAHLVLEEKSSEKNEDFAAHPGEDAVP-------TGPDCQA-KSTPVIVS 1489
TL P+ ++EE ++E +ED P + + T + QA K+TP + S
Sbjct: 1131 AHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDS 1190
Query: 1490 A---TTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIE-DLEPENGILELETK 1545
+ ++ D +G++ + + + + +E + +P+ G +
Sbjct: 1191 SPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQAS 1250
Query: 1546 SSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASA 1605
+ L NI Q + Q +E Q QA V+K ++ QE +K + + S+
Sbjct: 1251 TLALQSNITQCLLGQ---------PWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESS 1301
Query: 1606 QDETPITSAKEESESTAVGQAHSDISKDMS-----EAS---EKTMTVEVEGSTVNDQQLE 1657
+ K + A S K + EAS EKT T +G D+
Sbjct: 1302 RKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTS-KGKAKRDKASG 1360
Query: 1658 EVVLPSEEEGGGA----GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSA 1713
+V E++G G+ G K PE E ++K + +G D +P+++
Sbjct: 1361 DV---KEKKGKGSLGSQGAKDEPE--------EELQKGM----GTVEGGDQSNPKSK--- 1402
Query: 1714 LADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERE 1773
K+K+K D ++ + ++ + ++ KA T ++ QK++++
Sbjct: 1403 --------------------KEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKKK 1442
Query: 1774 SAKS 1777
K+
Sbjct: 1443 KKKT 1446
Score = 80.5 bits (197), Expect = 1e-14
Identities = 242/1224 (19%), Positives = 414/1224 (33%), Gaps = 211/1224 (17%)
Query: 186 KKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPS-----LGAGEAASKESEPKQSTEKPE 240
KK + P + + +++E E + S LGA +S + + K TEK
Sbjct: 74 KKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAG 133
Query: 241 ETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFF 300
+T P +G+ V ++ EPS A + T E GS F
Sbjct: 134 KT-------GNSMPHPATGKTVANLLSGKSPRKSAEPS--ANTTLVSETEEEGSV-PAFG 183
Query: 301 TQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQE 360
G ED +S+ +T+ +GK V ++ AS + +
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSD----------ETDVEGKPSVKPAQVKASSVSTKES 233
Query: 361 PAESAH---------EPRLSA----EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEK 407
PA A P++ ++ + P EE S +G E+ AP T +
Sbjct: 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGT-----R 288
Query: 408 IEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLK 467
+V E + +V ++ + K G A + ++ + +P ++
Sbjct: 289 SQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGA-----VASQTKAGKPEEDSESSS 343
Query: 468 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLS--SQERMKVQGSPLKKLFTSTGL 525
E E+ T A + +L G S+V S ++E + +P T +
Sbjct: 344 EESSDSEEETPAA-----KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398
Query: 526 KKLSGKKQKGKRGGGDEESGEHTQVPADS-PDSQEEQKGESSASSPEEPEEITC----LE 580
K K++ EES + PA + P + Q +SA + E P + +
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458
Query: 581 KGLAEVQ-QDGEAEEGATSDGEKK---RE-------------------------GVTPWA 611
G A Q Q G+ EE + S E+ RE G+ P
Sbjct: 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLG 518
Query: 612 SFKKMVTP-KKRVRRPS------ESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP 664
V P K PS E D E ++ ++ + + QE+ G++ +
Sbjct: 519 KGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA 578
Query: 665 KPEE------PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQK----- 713
KP P++ +V +A + +S+ S+D E P AM K
Sbjct: 579 KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKI 638
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
K+T T A ++ G+ +P +AG+ T G S + P + S
Sbjct: 639 PQTKACPKKTNT---TASAKVAPVRVGTQAPRKAGTATSPAGSSPAVA-GGTQRPAEDSS 694
Query: 774 SKLEEKSEDSIAGSGVE-----------HSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK 822
S E SE+ G V + P K +PG K P
Sbjct: 695 SSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPG--KTGPTVT 752
Query: 823 QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK 882
Q +A ++ + E DS+ A P +V++ + +A A +A P K
Sbjct: 753 QVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPA--AARAPSAKGT----- 805
Query: 883 ELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQ------------------ 924
+A AA ++RSPS + V P
Sbjct: 806 ----------ISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVA 855
Query: 925 VEAEAALLTEE---VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE---AVTA 978
A+A EE E E +EEE T+ + P + + ++ A+ +P A T
Sbjct: 856 TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 915
Query: 979 AETAGPLGAEEGTE---ASAAEETTEMVSAVSQLTDS-----------PDTT---EEATP 1021
GP A+ G + S++EE+ A + +T + P+ + ATP
Sbjct: 916 PGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATP 975
Query: 1022 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTG------GPEDVLQPVQRAEAE 1075
Q P + R ++ ++ + + ++E +P T V P
Sbjct: 976 AQAQAASTP---RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 1076 RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSEL 1135
A AS K+ + + + T+ + + T+P+S + T + +L
Sbjct: 1033 PKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKL 1092
Query: 1136 VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDA-------PGTTQK 1188
QA T A S + DS ++ + SE DG P A P T+
Sbjct: 1093 PEVQQA-TKAPESSDD-------SEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTET 1144
Query: 1189 --DEIVEIHEENEVASGTQ---SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL 1243
+E E++V + +Q SG PA + A +D
Sbjct: 1145 LVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDP 1204
Query: 1244 EHTDKEVSVETVSILSKTEGTQEA 1267
+ + + +LS G +EA
Sbjct: 1205 DGKQEAKPQQAAGMLSPKTGGKEA 1228
Score = 69.7 bits (169), Expect = 2e-11
Identities = 256/1311 (19%), Positives = 459/1311 (35%), Gaps = 196/1311 (14%)
Query: 584 AEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSAT- 642
+E+ + +AEE A +K R V+ SE ++E E + K+
Sbjct: 57 SELGRKRKAEEDAALQAKKTR------------VSDPISTSESSEEEEEAEAETAKATPR 104
Query: 643 LSSTESTA------SEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGS 696
L+ST S+ S M+E+ K E+ + A + G S +++ S
Sbjct: 105 LASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPS 164
Query: 697 SS-------DEEGGPKAMGGDHQ-------KADEAGKDKETGTDGI-LAGSQEHDPGQGS 741
++ +EEG A G + +AD + +D + +D + G P Q
Sbjct: 165 ANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224
Query: 742 SS-------PEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTP 794
+S P + +P G+ K P K K EE+SE S GS E P
Sbjct: 225 ASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAP 284
Query: 795 ---DTEPGKEESWVSIK------KFIPGR-RKKRPDGK------QEQA--PVEDAGPTGA 836
++ E + ++ K PG+ P GK Q +A P ED+ +
Sbjct: 285 AGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSE 344
Query: 837 NEDDS--DVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAA----------------- 877
DS + PA L + A + + + E P + AA
Sbjct: 345 ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAG 404
Query: 878 -----TEVSKELSESQVHMMAAAVADG----TRAATIIEERSPSWISASVTEPLEQVEAE 928
++ S E S+S+ A A G RAA+ + SP A+ P + A
Sbjct: 405 KREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR-KGAAPAPPRKTGPAA 463
Query: 929 AALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAE 988
A + + E + EE + E L A+ + ++ P + GPLG
Sbjct: 464 AQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMG---MGPLGKG 520
Query: 989 EG-TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVA 1047
G T DS ++EE++ + E QE+ +LQA
Sbjct: 521 AGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQA-- 578
Query: 1048 EKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFT 1107
+ + P G P+ + +AE+P + +E+S ++ +D +A A T
Sbjct: 579 ----KPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESS--EESSDSADSEEAPAAMTAAQA 632
Query: 1108 QGKV-VGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP 1166
+ + + QT ++ K T S + + + QA AG + A+ + P
Sbjct: 633 KPALKIPQT--KACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAV-AGGTQRP 689
Query: 1167 TDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVP-----AQKERP 1221
+ + ++ + G V + + V G Q +A +VP Q P
Sbjct: 690 AEDSSSSEESDSEEEKTGLA-----VTVGQAKSVGKGLQ---VKAASVPVKGSLGQGTAP 741
Query: 1222 PAPSS---FVFQEETKEQSKMEDTLEHTD-KEVSVETVSILSKTEGTQEADQYADEKTKD 1277
P V Q + ++Q E + E +D +E + + + + TQ A +
Sbjct: 742 VLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPS 801
Query: 1278 VPFFEGLEGSIDTGITVSREK-VTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVERE 1336
G + T ++++ ++V + + + S K+ + + +
Sbjct: 802 AKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQ 861
Query: 1337 MVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1396
+ + +E E ++ + E ET V ++ P AKE S +G+
Sbjct: 862 TGPEEDSGSSEEE----SDSEEEAETLAQVKPSGKTHQIRAALAP----AKE-SPRKGAA 912
Query: 1397 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1456
P G+ + Q S ++EE GE + + + ++P L+ +
Sbjct: 913 PTPPGKTGPSAAQAGKQDDSGS-----SSEESDSDGEAPAAVTSAQVIKPP---LIFVDP 964
Query: 1457 SSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVD 1516
+ + G A P QA STP A+ SS E E + + +
Sbjct: 965 N-------RSPAGPAATPA--QAQAASTPRKARASESTARSSSSESEDEDVIP-ATQCLT 1014
Query: 1517 EQVACQEVKVSVAIEDLEPENGILELET--KSSKLVQNIIQ----TAVDQFVRTEETATE 1570
+ V + A + P+ + + +SS++ Q T VD V T +
Sbjct: 1015 PGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSP 1074
Query: 1571 MLTS------------ELQTQAHVIKA--------DSQDAGQETEKEGEEPQASAQDETP 1610
TS +L KA DS D+ +E++GE PQ + T
Sbjct: 1075 QSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134
Query: 1611 ITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA 1670
+ +E T V + ++ S+D A +++ L + P
Sbjct: 1135 VGPTPSRTE-TLVEETAAESSEDDVVAPSQSL-------------LSGYMTPGLTPANSQ 1180
Query: 1671 GTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDT 1730
+K+ P+ D ++ S + K+D G P+ L + +GG S T
Sbjct: 1181 ASKATPKLDSSPSVS-----STLAAKDDPDGKQEAKPQQAAGML--SPKTGGKEAASGTT 1233
Query: 1731 NGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTE 1781
+K K+ A + + S + + Q + Q + S LTE
Sbjct: 1234 PQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTE 1284
Score = 66.6 bits (161), Expect = 2e-10
Identities = 274/1432 (19%), Positives = 471/1432 (32%), Gaps = 190/1432 (13%)
Query: 499 EVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQ 558
EV+ S Q+ Q L ++T G+K+K + + P + +S
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 559 EEQKGESSASSPEEPE-------------EITCLEKGLAEVQQDGEAEEGATSDGEKKR- 604
EE++ + ++ P + EK AE ++ G+ K
Sbjct: 89 EEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTV 148
Query: 605 EGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTEST--ASEMQEEMKGSVE 662
+ S +K P SE+++E + +A S A E+ S +
Sbjct: 149 ANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSD 208
Query: 663 EPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKE 722
E E V ++ S ++A + P+ GG A A K +E
Sbjct: 209 ETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE 268
Query: 723 TGTDGILAGSQEHDPGQGSSSPEQAGSP-------------TEGEGVSTWESFKRLVTPR 769
E + G+ S +A T G+G + K
Sbjct: 269 ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVAS 328
Query: 770 KKSKSKLEEKSEDSI-AGSGVEHSTPDTE---PGKEESWVSIKKFIPGRRKKRPDGKQEQ 825
+ K EE SE S S E TP + K S K+ P
Sbjct: 329 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 388
Query: 826 APVEDAGP------TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATE 879
AP GP G E+DS S + + E+ QA+ S + P+ +AA+
Sbjct: 389 APPGKTGPAVAKAQAGKREEDSQ-------SSSEESDSEEEAPAQAKPSGKAPQVRAASA 441
Query: 880 VSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLER 939
+KE S + A G AA + + +S E EA AA+ +V
Sbjct: 442 PAKE-SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 940 EVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEA-VTAAETAGPLGAEEGTEASAAEE 998
+ +P + P + A TP A V E +EE +++S E
Sbjct: 501 GKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEV 560
Query: 999 TTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEES---- 1054
T + A + S +A P G P ++ +Q AEK + S
Sbjct: 561 PTAVAPAQEK---SLGNILQAKPTSSPAKGPP-----QKAGPVAVQVKAEKPMDNSESSE 612
Query: 1055 QLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQ 1114
+ + E+ + A+A+ + + K+T+ + K
Sbjct: 613 ESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTA 672
Query: 1115 TTPESFEKA-----PQVTESIESSELVTTCQAET-LAGVKSQEMVMEQAIPPDSVETPT- 1167
T+P A + E SSE + + +T LA Q + + + + P
Sbjct: 673 TSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVK 732
Query: 1168 DSETDGSTPV-ADFDAPGTTQ-KDEIVEIHEENEVASGTQSGG------------TEAEA 1213
S G+ PV P TQ K E E E +E S ++ T+A+A
Sbjct: 733 GSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKA 792
Query: 1214 VPAQKERPPAPSSF---------VFQEETKEQSKMEDTLEHTDKEVSV----ETVSILSK 1260
PA P A + Q + + SK++ + + + +V + K
Sbjct: 793 NPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGK 852
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG-TEEAECKKDDA 1319
T Q E+ GS + E T +K G T + A
Sbjct: 853 AVATAAQAQTGPEED---------SGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPA 903
Query: 1320 LELQSHAKSPPSPVER-EMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV 1378
E +P P + Q ++ + ++ E AVT ++ + L+
Sbjct: 904 KESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLI--- 960
Query: 1379 NVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASF-TLTAAAEEEKVLGETANI 1437
+D + + +P Q +A T + ++SE++ + ++ +E+E V+ T +
Sbjct: 961 ---FVDPNRSPAGPAATP----AQAQAASTPRKARASESTARSSSSESEDEDVIPATQCL 1013
Query: 1438 -------LETGETLEP--------AGAHLVLEEK--SSEKNEDFAAHPGEDAVPTGPDCQ 1480
+ T T P AGA E S K ++ A + AV T P
Sbjct: 1014 TPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATS 1073
Query: 1481 AKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQ---------------------- 1518
+ST V T K E ++ T SD+ ++
Sbjct: 1074 PQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT 1133
Query: 1519 -VACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQ 1577
V + +E+ E+ ++ S L+ + + AT L S
Sbjct: 1134 LVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPS 1193
Query: 1578 TQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQA----------- 1626
+ + D D QE +PQ +A +P T KE + T ++
Sbjct: 1194 VSSTLAAKDDPDGKQEA-----KPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1248
Query: 1627 ------HSDISKDMSEASEKTMTVEVEGSTVN------DQQLEEVVLPSEEEG--GGAGT 1672
S+I++ + +V+ S V +Q+ ++VV ++E G
Sbjct: 1249 ASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESR 1308
Query: 1673 KSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNS---ALADTDASGGLTKESPD 1729
K D A R +K + E G+ PE ++ A D + G KE
Sbjct: 1309 KRKLSGDQPAARTPRSKKK-KKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKG 1367
Query: 1730 TNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTE 1781
+ +D E ELQ+G E P++++E +K ++ E E
Sbjct: 1368 KGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1419
Score = 63.9 bits (154), Expect = 1e-09
Identities = 249/1223 (20%), Positives = 418/1223 (34%), Gaps = 234/1223 (19%)
Query: 16 PEGSSTPAEPEPSG--------GGPSAEAAPDTTADPAIAASDPATKLL---QKNGQLST 64
P +TPA P +G G P ++ + PA K L + +G+ S
Sbjct: 311 PGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQ 370
Query: 65 INGVAEQDELSLQEGDLN---GQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSK-RDS 120
+ + + S ++G G+ G + +EE+ +E + E ++ + S
Sbjct: 371 VGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPS 430
Query: 121 DK--EMATKSAVVHDITDDGQEETP-----------EIIEQIPSSESNLEELTQPTESQA 167
K ++ SA + G P ++ +Q S S+ EE E+ A
Sbjct: 431 GKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALA 490
Query: 168 NDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAG---- 223
K K + + T+ + + K G G PS G
Sbjct: 491 -------AMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEE 543
Query: 224 --EAASKESEPKQSTEKPEETLKREQ------------SHAEISPPAESGQAVEECKEE- 268
E++S+ES E P ++ S PP ++G + K E
Sbjct: 544 DSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEK 603
Query: 269 --GEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK 326
+ +E S SA+S +P Q + + PK+ AS K
Sbjct: 604 PMDNSESSEESSDSADSEEAPAAMTAA--------QAKPALKIPQTKACPKKTNTTASAK 655
Query: 327 KKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVS 386
P +V T+ KA A+ +S PA + R P+E+ S
Sbjct: 656 VA---PVRVGTQAPRKAGTATSPAGSS-------PAVAGGTQR----------PAEDSSS 695
Query: 387 GSQGPSEEKPAPLATEVFDEK-----IEVHQEEV-----VAEVHVSTVEERTEEQKTEV- 435
+ SEE+ LA V K ++V V + + + +T T+V
Sbjct: 696 SEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVK 755
Query: 436 -EETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPE 494
E+ S +EE E D+E A PA+ +K+T A +P K P
Sbjct: 756 AEKQEDSESSEE--ESDSEEAAASPAQVKTSVKKTQAKANP---AAARAPSAKGTISAPG 810
Query: 495 GVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES-GEHTQVPAD 553
VV+ + KV+ P++ ST L RG S G+ A
Sbjct: 811 KVVTAAAQAKQRSPSKVK-PPVRNPQNSTVLA----------RGPASVPSVGKAVATAAQ 859
Query: 554 SPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEE---GATSDGEKKREGVTPW 610
+ EE G S S E E T LA+V+ G+ + E R+G P
Sbjct: 860 AQTGPEEDSGSSEEESDSEEEAET-----LAQVKPSGKTHQIRAALAPAKESPRKGAAP- 913
Query: 611 ASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE--- 667
P K +++ K+D+ SS ES + S + KP
Sbjct: 914 ------TPPGKTGPSAAQAGKQDDSGS------SSEESDSDGEAPAAVTSAQVIKPPLIF 961
Query: 668 -EPKRKVDTSVSWEALICVGSSKKRAR------RGSSSDEEGG----------------- 703
+P R + A S+ ++AR R SSS+ E
Sbjct: 962 VDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNV 1021
Query: 704 ---PKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSS-----PEQAGSPTEGEG 755
P A KA AG + I G ++ P S P + T +
Sbjct: 1022 VTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQA 1081
Query: 756 VSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRR 815
T ++ P + +K E S+DS S + S+ E G+ + G
Sbjct: 1082 KGT-NKLRKPKLPEVQQATKAPESSDDSEDSS--DSSSGSEEDGEGPQGAKSAHTLVGPT 1138
Query: 816 KKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEY--DAVEREKMEAQQAQKSAEQPE 873
R + E+ E ++EDD P+ LS Y + +A +A +
Sbjct: 1139 PSRTETLVEETAAE------SSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSP 1192
Query: 874 QKAATEVSK-------ELSESQVHMMAAAVADGTRAA---TIIEERSPSW---------- 913
++T +K E Q M + G AA T + R P
Sbjct: 1193 SVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTL 1252
Query: 914 -ISASVTEPL---------EQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGD 963
+ +++T+ L QV+A + E+LE+E ++ T E + E+R
Sbjct: 1253 ALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE--RKKVVDTTKESSRKGWESRKR 1310
Query: 964 TVVSE--AELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATP 1021
+ + A TP + + LGA EG EAS + E T TT +
Sbjct: 1311 KLSGDQPAARTPRSKKKKK----LGAGEGGEASVSPEKT-------------STTSKGKA 1353
Query: 1022 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQL-PGTGGPEDVLQPVQRAEAERPEEQ 1080
++ G D++E++ + Q ++ +EE Q GT D P + E ++ +++
Sbjct: 1354 KRDKASG--DVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR 1411
Query: 1081 AEASGLKKETDVVLKVDAQEAKT 1103
+ K++ K +++++
Sbjct: 1412 KKDKEKKEKKKKAKKASTKDSES 1434
Score = 57.8 bits (138), Expect = 9e-08
Identities = 101/452 (22%), Positives = 163/452 (36%), Gaps = 65/452 (14%)
Query: 248 SHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGW 307
+H I+P A A +E K E P + V S G T Q +
Sbjct: 1027 AHPRIAPKASMAGA-----SSSKESSRISDGKKQEGPATQVDSAVG-TLPATSPQSTSVQ 1080
Query: 308 RKKTS-FRKPKEDEVEASEKKKEQEPEKVDT-------EEDGKAEVASEKLTASEQAHPQ 359
K T+ RKPK EV+ + K E + D+ EEDG+ ++ P
Sbjct: 1081 AKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPS 1140
Query: 360 EPAESAHEPRLSAEYEKVELPSEEQVSGSQGPS---EEKPAPLATEVFDEKIEVHQEEVV 416
E + + V PS+ +SG P A AT D V
Sbjct: 1141 RTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAA 1200
Query: 417 AEVHVSTVEERTEE------QKTEVEETA-GSVPAEELVEMDAEPQEAEPAKELVKLKET 469
+ E + ++ KT +E A G+ P + L
Sbjct: 1201 KDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQ 1260
Query: 470 CVSGED-PTQGADLSPD-EKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKK 527
C+ G+ P A + KVL++ E +V + + K S +KL +
Sbjct: 1261 CLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAAR 1320
Query: 528 LSGKKQKGKRGGGDEESGEHTQVPADSPDSQ-------------EEQKGESSASS---PE 571
K+K K G G E GE + P + + +E+KG+ S S +
Sbjct: 1321 TPRSKKKKKLGAG--EGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKD 1378
Query: 572 EPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDK 631
EPEE L+KG+ G E G S+ + K+E KK +R + +K
Sbjct: 1379 EPEEE--LQKGM------GTVEGGDQSNPKSKKE-------------KKKSDKRKKDKEK 1417
Query: 632 EDELDKVKSATLSSTESTASEMQEEMKGSVEE 663
+++ K K A+ +ES + + +++ K + E+
Sbjct: 1418 KEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1449
Score = 35.4 bits (80), Expect = 0.50
Identities = 29/140 (20%), Positives = 57/140 (40%), Gaps = 17/140 (12%)
Query: 216 KDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEE-CKEEGEEKQE 274
K LGAGE P++++ + KR+++ ++ G + K+E EE+ +
Sbjct: 1326 KKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQ 1385
Query: 275 KEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEK 334
K S S+ ++K K K+D+ + +KKK ++
Sbjct: 1386 KGMGTVEGGDQSNPKSK----------------KEKKKSDKRKKDKEKKEKKKKAKKAST 1429
Query: 335 VDTEEDGKAEVASEKLTASE 354
D+E + + +K TA +
Sbjct: 1430 KDSESPSQKKKKKKKKTAEQ 1449
>gi|238624188 diffuse panbronchiolitis critical region 1 protein [Homo
sapiens]
Length = 1393
Score = 82.4 bits (202), Expect = 4e-15
Identities = 262/1342 (19%), Positives = 451/1342 (33%), Gaps = 209/1342 (15%)
Query: 214 DHKDPSLGAGEAASKESEP----KQSTEKPEETLKREQSHAE--ISPPAESGQAVEEC-- 265
+H+ P ++++ +P ++S + + T ++S + I+P +S +
Sbjct: 114 NHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTT 173
Query: 266 -KEEGEEKQEK--EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 322
K K +K P + + S ++ + T F G + ++K++ K
Sbjct: 174 GKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAAS 233
Query: 323 ASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 382
+ K PE+ + ED + VAS+KL + QE +SA L
Sbjct: 234 KTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQE--------TISANELTQSLAEP 285
Query: 383 EQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSV 442
+ G P+P E E + +S E ++T E TA
Sbjct: 286 TEHGGRTANENNTPSPA------EPTENRERTANENTTLSPAEPIENRERTANENTA--- 336
Query: 443 PAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEM 502
A P E +E+ + T + +PT+ + + +E P E E
Sbjct: 337 ------PFPAGPTE---NREMTANENTTLFPAEPTEHGERTANENTTPSPAE-PTEHGER 386
Query: 503 LSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQV--------PADS 554
+++ P T G + + E GE T + PA+
Sbjct: 387 TANENTTPSPAEP-----TEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEP 441
Query: 555 PDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFK 614
+++E E++ SP P E ++ A E T + E A+ K
Sbjct: 442 TENRERTANENTTPSPAGPTE-----------NRETTANEKTTLSPVEPTENRETTANEK 490
Query: 615 KMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVD 674
+P + P+E+ + K+ T SS E T + + P P EP +
Sbjct: 491 TTPSPAE----PTENGQRTPFANEKT-TSSSAEPTEHGERTPLANENTTPSPAEPTENRE 545
Query: 675 TSVSWEALICVGSSKKRARRGSSSDEEGGPK-AMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + + + R ++E+ P A ++ + +K T + +
Sbjct: 546 RTANEKTTPSPAEPTENGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHE 605
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
E P ++ PTE + E+ TP ++ E + + T
Sbjct: 606 ERTPLANENTTPSPAEPTENRERTANEN----TTPSPAGPTENREMTANEKTTLFPAEPT 661
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E E S P +R E+ A PT E LS +
Sbjct: 662 ENRERTANEKTTS-SPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAE 720
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSW 913
E + A +K+ P + + +E+ A +G R E+ +P
Sbjct: 721 PTENRERTAN--EKTTPFPAEPTENR-ERTANENTTPSPAQPTENGDRTPLANEKTTP-- 775
Query: 914 ISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTP 973
S+ EP E + T E+ + EP AE TP
Sbjct: 776 ---SLAEPTENGKR-----TPFANEKTTSSSAEP------------------TEHAERTP 809
Query: 974 EAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIE 1033
A T+ P E E +A E+TT+ + ++ +S E+ TP P
Sbjct: 810 LA-NENTTSSPAEPTENRERTANEKTTQFPAEPTENRES-TANEKTTPFP----AEPTEN 863
Query: 1034 EQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVV 1093
+ + + AE + E P + L P + P E E +
Sbjct: 864 REWTANENTTLSPAEPTEHEEMTP-LANEKTTLSPAE------PTENGERT--------- 907
Query: 1094 LKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMV 1153
PFT K TTP S E + ++E+ T +AE + +
Sbjct: 908 -----------PFTNEK----TTPSSAEPTEHGERTPLANEITTPSRAEPTE--HGERIA 950
Query: 1154 MEQAIPPDSVETPTDSETDGSTPVADFDAPGT---TQKDEIVEIHEENEVASGTQSGGTE 1210
E+A P +P G T V + P + T+ E + EN S T+S TE
Sbjct: 951 NEKATP-----SPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANENTTTSPTES--TE 1003
Query: 1211 AEAVPAQKERPPAPSSFVFQEETKEQSKMEDTL-------EHTDKEVSVETVSILSKTEG 1263
A ++ P+P+ E + S E T+ EH + S + S +
Sbjct: 1004 HGERTANEKTTPSPAEPTEHGE-RTPSANEKTIPSPAKPTEHEEMTPSANENTTPSPVKP 1062
Query: 1264 TQEADQ--YADEKTKDVPFFEGLEGSIDTG--ITVSREKVTEVALK----GEGTEEAECK 1315
T+ ++ A+EK P EG + G T + EK+T K GE T K
Sbjct: 1063 TEHGEKTTLANEKITLSP-----EGPTEHGAKTTSANEKITPSLAKPTEHGERTTSPNDK 1117
Query: 1316 -----------KDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAV 1364
+D A +P P++ + EK T V E+ EH
Sbjct: 1118 ITSSAAESTEHRDRATSANVITPAPAEPIKHAKRTTLAHEKM----TQVTEKSTEHPEKT 1173
Query: 1365 TVSEEVSKQLLQTVNVPIIDGAKEVSSL-EGSPPPCLGQEEAVCTKIQVQSSEASFTLTA 1423
T + E + +T P + K + + + +P P E T + ++ +A T
Sbjct: 1174 TSTTE---KTTRTPEKPTLYSEKTICTKGKNTPVPEKPTENLGNTTLTTETIKAPVKSTE 1230
Query: 1424 AAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKS 1483
E +TA + +T + L SS N+ H VPTG S
Sbjct: 1231 NPE------KTAAVTKTIKPSVKVTGDKSLTTTSSHLNKTEVTH----QVPTG------S 1274
Query: 1484 TPVIVSATTKKGLSSDLEGEKT 1505
+I S T ++S+ G ++
Sbjct: 1275 FTLITSRTKLSSITSEATGNES 1296
Score = 65.1 bits (157), Expect = 6e-10
Identities = 181/883 (20%), Positives = 299/883 (33%), Gaps = 118/883 (13%)
Query: 940 EVIAEEEPPTVTEPLPENREARGD---TVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 996
++ A + T PE E D TV S+ LT ET + A E T++ A
Sbjct: 228 KITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQET---ISANELTQSLA- 283
Query: 997 EETTEMVSAVSQLTDSPD----------TTEEATPVQEVEGGVPDIEEQERRTQEVLQAV 1046
E TE + ++P T E T + E IE +ER E
Sbjct: 284 -EPTEHGGRTANENNTPSPAEPTENRERTANENTTLSPAE----PIENRERTANENTAPF 338
Query: 1047 AEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPF 1106
E ++ T L P + P E E + + T + EP
Sbjct: 339 PAGPTENREM--TANENTTLFPAE------PTEHGERTANENTTP---------SPAEPT 381
Query: 1107 TQGKVVGQ--TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVE 1164
G+ TTP E + +++ T+ AE+ + + E P +
Sbjct: 382 EHGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEP 441
Query: 1165 TP----TDSETDGSTPVADFDAPGTTQKDEI----VEIHEENEVASGTQSGGTEAEAVPA 1216
T T +E +P + TT ++ VE E E + ++ + AE
Sbjct: 442 TENRERTANENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTEN 501
Query: 1217 QKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTK 1276
+ P F E S E T EH ++ + S E T+ ++ A+EKT
Sbjct: 502 GQRTP-------FANEKTTSSSAEPT-EHGERTPLANENTTPSPAEPTENRERTANEKTT 553
Query: 1277 DVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVERE 1336
P E E T + + EK T E TE + + S + P ER
Sbjct: 554 PSPA-EPTENGDRTPL--ANEKTTPSL--AEPTENGQRTPFANEKTTSSSAEPTEHEERT 608
Query: 1337 MVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSP 1396
+ + AEPT E T + + + + + A+ + E +
Sbjct: 609 PLANENTTPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTA 668
Query: 1397 PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEK 1456
A T+ ++ A+ T+++ E GE + TL PA E
Sbjct: 669 NEKTTSSPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERT 728
Query: 1457 SSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTT-SLKWKSDEV 1515
++EK F A P E+ T + +T + T+ G + L EKTT SL ++
Sbjct: 729 ANEKTTPFPAEPTENRERTANE----NTTPSPAQPTENGDRTPLANEKTTPSLAEPTENG 784
Query: 1516 DEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSE 1575
E S + E E ++ +N + + E TA E T
Sbjct: 785 KRTPFANEKTTSSSAEPTEHAE-------RTPLANENTTSSPAEPTENRERTANEKTT-- 835
Query: 1576 LQTQAHVIKADSQDAGQETEKEGEEP----QASAQDETPITSAK--EESESTAVGQAHSD 1629
Q A + A ++T EP + +A + T ++ A+ E E T + +
Sbjct: 836 -QFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPAEPTEHEEMTPLANEKTT 894
Query: 1630 IS-KDMSEASEKTMTVEVEGSTVNDQQLE---------EVVLPSEEEGGGAGTKSVPEDD 1679
+S + +E E+T + + + + E E+ PS E P +
Sbjct: 895 LSPAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSRAE---------PTEH 945
Query: 1680 GHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKE 1739
G + E+ S +P E + + DT S P NG +
Sbjct: 946 GERIANEKATPSPAKPTE----------HGETTVNEDTTPSSA----EPTENGERTPLAN 991
Query: 1740 DAQEVELQEGKVHSE--SDKAITPQAQEELQKQERESAKSELT 1780
+ E H E +++ TP E + ER + +E T
Sbjct: 992 ENTTTSPTESTEHGERTANEKTTPSPAEPTEHGERTPSANEKT 1034
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 82.0 bits (201), Expect = 5e-15
Identities = 349/1765 (19%), Positives = 614/1765 (34%), Gaps = 351/1765 (19%)
Query: 189 KTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGE---------AASKESEPKQSTEKP 239
+TEK V +K +G D P AG+ + E +P S
Sbjct: 1921 RTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSK 1980
Query: 240 EETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKF 299
E ++ S E+ +SGQ + K E + + + E V E G +
Sbjct: 1981 TERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQR 2040
Query: 300 FTQGWAGWRKKTSFRKPKEDEVEASEKKKEQE-PEKVDTEEDGKAEVASEKLTASEQAHP 358
Q K R P E+ + K + GK +V S K+ Q+ P
Sbjct: 2041 EAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVP 2100
Query: 359 QEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAE 418
+E E +E K ++ E+ Q + K + +EV +++E + +
Sbjct: 2101 EE------ESHRESEVPKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDK----- 2149
Query: 419 VHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 478
+ E TE+ + +++ S P +D E PA + L+ + G
Sbjct: 2150 YQQFRLSEETEKAQLHLDQVLTS-PFNTTFPLDYMKDEFLPA---LSLQSGALDGS---- 2201
Query: 479 GADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQG--------------SPLKKLFTSTG 524
++ +E V P ++ +SS+E K +G SP KK TG
Sbjct: 2202 -SESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFSP-KKSEEQTG 2259
Query: 525 LKKLSGKKQ--------------KGKRGGGDEESGEHTQVPADSPDS--QEEQKGESSAS 568
K S K + K GG +E T+ S +S +E G +
Sbjct: 2260 ETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTESFQKEATLGSPKDT 2319
Query: 569 SPEEPEEIT-CLEKGLAEVQQDGEAEEGATSDGEKK--------------REGVTPWASF 613
SP+ ++ T LA+ G EE A +G++ +E
Sbjct: 2320 SPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQTDSEVQESTATSDET 2379
Query: 614 KKMVTPKKRVRRPS--ESDKEDELDKVKSATLS----STESTASEMQEEMKGSVEEPKPE 667
K + P+ V+ + ES + + + L+ +E ++ + + S ++
Sbjct: 2380 KALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDSLAVSHKDSLEA 2439
Query: 668 EPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG---DHQKADEAGKDKETG 724
P + ++S + K+ R S PK G H A E
Sbjct: 2440 SPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTELL 2499
Query: 725 TDGILA---------GSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSK 775
T+ GS E D + +S E +G + E VTP+ S
Sbjct: 2500 TEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKTTDVST 2559
Query: 776 -----LEEKSEDSIAGSGVEHS-TPDTEPGKEESWVSIKKFIPGRRKKRPDGKQE----- 824
+ E +E+ + +G + TP+ E K + + + + K++ D K+E
Sbjct: 2560 PKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEE 2619
Query: 825 -----------QAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPE 873
V++ TG+ ED+S VP +V E+++ S+E
Sbjct: 2620 SSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVT-----------SESRKVSSSSE--- 2665
Query: 874 QKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASV--TEPLEQVEAEAAL 931
SE ++ + G +I + PS + +S+ E+V+ + +
Sbjct: 2666 -----------SEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPVV 2714
Query: 932 LTEEVLEREVIAEEEPPTVTEP------LPENREARGDTVVSEAELTPEAVTAAETAGPL 985
+ + +EEP E L E+R A V +EAE +T P
Sbjct: 2715 SKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHA----VSTEAEDRSYDKLNRDTDQPK 2770
Query: 986 GAE-EGTEASAAEETTEMVSAVSQLTDSPDTTEE-----------ATPVQEVEGGVPDIE 1033
+ G EA + + VS+ Q D E+ T ++ EG D+
Sbjct: 2771 ICDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTHEKDTEGEELDVS 2830
Query: 1034 EQERRTQEVLQAVAEKVKEESQLP------GTGGPEDV--LQPVQRAEAERPEEQAEA-- 1083
E + +E S LP G ED+ +Q+ E + +E E
Sbjct: 2831 RAESPQAD---CPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEVTKTDETFENLP 2887
Query: 1084 -------SGLKKETD-----VVLKVDAQEAK------TEPFTQGKVVGQTTPESFEKAPQ 1125
S + +TD V + A+ + T P+ V Q+ S E Q
Sbjct: 2888 KDCPSQDSSITTQTDRFSMDVPVSDLAENDEIYDPQITSPYEN--VPSQSFFSSEESKTQ 2945
Query: 1126 V----TESIESSEL-------------VTTCQAETLAGVKS----QEMVMEQA------- 1157
T S SSE+ V + + T+ +S Q++ ME
Sbjct: 2946 TDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTVLSKESNFEGQDIKMESQQESTLWE 3005
Query: 1158 IPPDSVETPTDSETDGSTPVA------------DFDAPGTTQ---KDEIVE--IHEENEV 1200
+ DSV + + +T V D D+ ++ DE E + EE +
Sbjct: 3006 MQSDSVSSSFEPTMSATTTVVGEQISKVIITKTDVDSDSWSEIREDDEAFEARVKEEEQK 3065
Query: 1201 ASGT----QSGGTEAEAVPAQ---KERPPAPSS--FVFQEETKEQSKMEDTLEHTDKEVS 1251
G QS GT + PA+ +E P F+FQE + ++ T + +
Sbjct: 3066 IFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYA 3125
Query: 1252 VETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEE 1311
E+ + ++E D K EG G+ + S E + K +E
Sbjct: 3126 DESFHFFQIGQESREETLSEDVK-------EGATGADPLPLETSAESLALSESKETVDDE 3178
Query: 1312 AECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVS 1371
A+ DD E + + + +M + E E V + L
Sbjct: 3179 ADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLP------------ 3226
Query: 1372 KQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVL 1431
+QT ++P + G K++S + S P Q + V S + ++ EE+K +
Sbjct: 3227 --TVQTGDIPPLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSV 3284
Query: 1432 GETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSAT 1491
E + +N F + V T P STP SA
Sbjct: 3285 IEIPT--------------------APMENVPFTESKSKIPVRTMP----TSTPAPPSAE 3320
Query: 1492 TKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLV- 1550
+ +S D S + ++ DE ++ V V ++ +E + + +L+T K V
Sbjct: 3321 YESSVSEDF-----LSSVDEENKADEAKPKSKLPVKVPLQRVEQQ--LSDLDTSVQKTVA 3373
Query: 1551 ---QNIIQTAVDQFVRTEETATEM---LTSELQTQAHV-IKADSQDAGQETEKEGEE--- 1600
Q++ A D ++E A+ + ++T+++ + +S++ +E E E EE
Sbjct: 3374 PQGQDMASIAPDNRSKSESDASSLDSKTKCPVKTRSYTETETESRERAEELELESEEGAT 3433
Query: 1601 ------PQASAQDETPITSAKEESESTAVGQAH------------SDISKDMSEASEKTM 1642
+ + + +S + + T + H +IS + S+ ++
Sbjct: 3434 RPKILTSRLPVKSRSTTSSCRGGTSPTKESKEHFFDLYRNSIEFFEEISDEASKLVDRLT 3493
Query: 1643 TVEVEGSTVNDQQ----LEEVVL----PSEEEGGGAGTKSVPED--DGHALLAERIEKSL 1692
E E V+D + LE V+ P E E SVPED D + E IE +L
Sbjct: 3494 QSEREQEIVSDDESSSALEVSVIENLPPVETE------HSVPEDIFDTRPIWDESIE-TL 3546
Query: 1693 VEPKEDEKG-DDVDDPENQNSALAD 1716
+E DE G D +DP+++ + +
Sbjct: 3547 IERIPDENGHDHAEDPQDEQERIEE 3571
Score = 78.2 bits (191), Expect = 7e-14
Identities = 323/1614 (20%), Positives = 538/1614 (33%), Gaps = 256/1614 (15%)
Query: 218 PSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISP--------------------PAE 257
PSL + A PK + + + H +SP PA
Sbjct: 1811 PSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPAS 1870
Query: 258 SGQAVEECK--EEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKK---TS 312
S E+ + + P S ++ P S +G T K+ K +
Sbjct: 1871 SSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSP 1930
Query: 313 FRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVA-SEKLTASEQAHPQEPAESAHEPRLS 371
R K V S + + +P + + V+ S K P E E
Sbjct: 1931 GRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSV 1990
Query: 372 AEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEE--VVAEVHVSTVEERT- 428
E K ++ G E K A K+ V +E+ ++ + E +T
Sbjct: 1991 RELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTI 2050
Query: 429 -EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELV---------------------KL 466
Q+ V TA S + + + ++A KE V ++
Sbjct: 2051 KRGQRLPVTGTAESKRGVRVSSIGVKKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEV 2110
Query: 467 KETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVE-------MLSSQERMKVQ------- 512
+ ++ E +SPD K + E + E+E S+E K Q
Sbjct: 2111 PKEKMADEQGDMDLQISPDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVL 2170
Query: 513 GSPLKKLFTSTGLKK--LSGKKQKGKRGGGDEESGEHTQVPADSP-----------DSQE 559
SP F +K L + G ES ++ V A SP S+E
Sbjct: 2171 TSPFNTTFPLDYMKDEFLPALSLQSGALDGSSESLKNEGV-AGSPCGSLMEGTPQISSEE 2229
Query: 560 EQKGESSASSPE-EPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVT 618
K E A +PE PE ++ K E Q GE +E K E T S K+ T
Sbjct: 2230 SYKHEGLAETPETSPESLSFSPKKSEE--QTGETKEST------KTETTTEIRSEKEHPT 2281
Query: 619 PKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVS 678
K + SE ++ + T S ST S +E GS PK PKR+ D + S
Sbjct: 2282 TKD-ITGGSE-------ERGATVTEDSETSTESFQKEATLGS---PKDTSPKRQDDCTGS 2330
Query: 679 WEALICVGSSKKRARRGSSSDE--EGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 736
C + K G + + + G + G K D E + +
Sbjct: 2331 -----CSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQ---TDSEVQESTATSDETKAL 2382
Query: 737 PGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDT 796
P +S G+ ++ +GV L P + S+ L ++DS+A S +
Sbjct: 2383 PLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSE-VLSAVADDSLAVSHKDSLEASP 2441
Query: 797 EPGKEESWVSIKKFIPGRRKKRP-DGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAV 855
S + P K+ P E +PVE G +PA V +E
Sbjct: 2442 VLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGIFPSHFPLPAAVAKTE---- 2497
Query: 856 EREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS 915
TEV+ S +A D +++E S +S
Sbjct: 2498 --------------------LLTEVASVRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLS 2537
Query: 916 ASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPE- 974
T E+V E T +V + +P + E E+ G+ + TPE
Sbjct: 2538 PD-TPSSEEVSYEVTPKTTDV------STPKPAVIHECAEEDDSENGE----KKRFTPEE 2586
Query: 975 ----AVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQ----EVE 1026
VT + L E + +E + S+ S D+ + + P E E
Sbjct: 2587 EMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDE 2646
Query: 1027 GGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGL 1086
GVP + E R + + +E E +QL + +PV R + P + S
Sbjct: 2647 SGVPVLVTSESRK---VSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNS 2703
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAG 1146
E ++ +K F + + +S E+ + E V+T +AE +
Sbjct: 2704 SPEE---VQFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVST-EAEDRSY 2759
Query: 1147 VKSQEMVMEQAIPPDSVETPTDSETDGSTPVAD-FDAPGTTQKDEIVEIHEENEVASGTQ 1205
K + I D S + + PV+ +P DE I++E+ GT
Sbjct: 2760 DKLNRDTDQPKI-CDGHGCEAMSPSSSAAPVSSGLQSPTGDDVDEQPVIYKESLALQGTH 2818
Query: 1206 SGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEV--SVETVSILSKTEG 1263
TE E + R +P + E S + L KE+ + S + KTE
Sbjct: 2819 EKDTEGEELDV--SRAESPQADCPSESFSSSSSLPHCLVSEGKELDEDISATSSIQKTEV 2876
Query: 1264 TQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQ 1323
T + D+ + KD P S D+ IT ++ + + E E
Sbjct: 2877 T-KTDETFENLPKDCP-------SQDSSITTQTDRFSMDVPVSDLAENDEI-------YD 2921
Query: 1324 SHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPII 1383
SP V + E KT+ + H +VT++ V ++ + + +
Sbjct: 2922 PQITSPYENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTV 2981
Query: 1384 DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGET 1443
+ S+ EG Q+E+ ++Q S +SF T +A V + + ++ T
Sbjct: 2982 --LSKESNFEGQDIKMESQQESTLWEMQSDSVSSSFEPTMSATTTVVGEQISKVIITKTD 3039
Query: 1444 LEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGE 1503
++ + E+ +E F A E+ GL D + +
Sbjct: 3040 VDSDSWSEIRED-----DEAFEARVKEEEQKI------------------FGLMVDRQSQ 3076
Query: 1504 KTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVR 1563
TT D P E T +S+ + Q F
Sbjct: 3077 GTT------------------------PDTTPARTPTEEGTPTSEQNPFLFQEG-KLFEM 3111
Query: 1564 TEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKE-----ES 1618
T A +M ++ Q++ +ET E + A+ D P+ ++ E ES
Sbjct: 3112 TRSGAIDMTKRSYADESFHFFQIGQESREETLSEDVKEGATGADPLPLETSAESLALSES 3171
Query: 1619 ESTAVGQAH---SDISKDMSE--ASEKTMTVEVEGSTVNDQQLEEVV------LPSEEEG 1667
+ T +A D+S+++ E AS+ + ++ S + +E V LP+ + G
Sbjct: 3172 KETVDDEADLLPDDVSEEVEEIPASDAQLNSQMGISASTETPTKEAVSVGTKDLPTVQTG 3231
Query: 1668 -----GGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDD--PENQNSAL 1714
G S P+ A+ + +L ++GDD D PE Q S +
Sbjct: 3232 DIPPLSGVKQISCPDSSEPAVQVQLDFSTLTRSVYSDRGDDSPDSSPEEQKSVI 3285
Score = 68.9 bits (167), Expect = 4e-11
Identities = 306/1527 (20%), Positives = 528/1527 (34%), Gaps = 297/1527 (19%)
Query: 266 KEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASE 325
+ E +++QE+E ++E ++ET S K + + E SE
Sbjct: 1458 ESESDQEQEEEIDMTSEKNDETESTET-SVLKSHLVN-------EVPVLASPDLLSEVSE 1509
Query: 326 KKKE--QEPEKVDTEEDGKA-EVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSE 382
K++ + + T+ KA + ++L + + P EP E R+ + EKV +E
Sbjct: 1510 MKQDLIKMTAILTTDVSDKAGSIKVKELVKAAEEEPGEPFEIVE--RVKEDLEKV---NE 1564
Query: 383 EQVSGSQGPSEEKPAPLATE----------VFDEKIEVHQEEVVAEV-HVSTVEERTEEQ 431
SG+ E +E V DE+IE +++ E+ VE R +++
Sbjct: 1565 ILRSGTCTRDESSVQSSRSERGLVEEEWVIVSDEEIEEARQKAPLEITEYPCVEVRIDKE 1624
Query: 432 -KTEVEETAGSV------PAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSP 484
K +VE+ + + V + E + K K + V +G D+ P
Sbjct: 1625 IKGKVEKDSTGLVNYLTDDLNTCVPLPKEQLQTVQDKAGKKCEALAVGRSSEKEGKDIPP 1684
Query: 485 DEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEES 544
DE S+Q++ K S G+KK +K K K+ +E
Sbjct: 1685 DETQ---------------STQKQHK----------PSLGIKKPVRRKLKEKQKQKEEGL 1719
Query: 545 GEHTQVPADSPDSQEEQKGESSASSPEEPEEITCL-----EKGLAEVQQDGEAEEGATSD 599
+ S EE GE +PE + E + ++ +A + D
Sbjct: 1720 QASAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVED 1779
Query: 600 GEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKG 659
+K R + K+ V PKK RP + +K
Sbjct: 1780 EQKGRSKLPIRVKGKEDV-PKKTTHRPHPA-----------------------ASPSLKS 1815
Query: 660 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK 719
P PK + +++S SS K R H + K
Sbjct: 1816 ERHAPGSPSPKTERHSTLS--------SSAKTER-----------------HPPVSPSSK 1850
Query: 720 DKETGTDGILAGSQEHDPGQGSSSPEQ---AGSPTEGEGVSTWESFKRLVTPRKKSKSKL 776
++ A ++ H P SS E+ T+ E S S K P K
Sbjct: 1851 TEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKT 1910
Query: 777 EEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAG---- 832
+++ S +G +H P PG+ E K +P R D Q PV AG
Sbjct: 1911 DKRPPVSPSGRTEKH--PPVSPGRTE------KRLPVSPSGRTDKHQ---PVSTAGKTEK 1959
Query: 833 --PTGANEDDSDVPAVVPLSEYDAVE-----REKMEAQQA-------------QKSA--E 870
P + P V P S+ + +E RE M+A Q+ KSA +
Sbjct: 1960 HLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQK 2019
Query: 871 QPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAA 930
QP++K V KE ++ A T TI + + ++ +V +
Sbjct: 2020 QPQEKGKVRVEKEKGP----ILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSSIGV 2075
Query: 931 LLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSE----------AELTPEAVTAAE 980
+ +E + + P + +PE R V E +++P+ T+ +
Sbjct: 2076 KKEDAAGGKEKVLSHKIPEPVQSVPEEESHRESEVPKEKMADEQGDMDLQISPDRKTSTD 2135
Query: 981 TAGPLGAE-----EGTEASAAEETTEMVSAVSQLTDSPDTT--------EEATPVQEVEG 1027
+ + E + + +EET + + Q+ SP T +E P ++
Sbjct: 2136 FSEVIKQELEDNDKYQQFRLSEETEKAQLHLDQVLTSPFNTTFPLDYMKDEFLPALSLQS 2195
Query: 1028 GVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAE--AERPEEQAEASG 1085
G D + + + V + + E G P+ + + E AE PE E+
Sbjct: 2196 GALDGSSESLKNEGVAGSPCGSLME-------GTPQISSEESYKHEGLAETPETSPESLS 2248
Query: 1086 LKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIE--SSELVTTCQAET 1143
+ K + Q +T+ T+ + TT EK T+ I S E T ++
Sbjct: 2249 FSPK-----KSEEQTGETKESTKTET---TTEIRSEKEHPTTKDITGGSEERGATVTEDS 2300
Query: 1144 LAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASG 1203
+S + P D+ D T GS VA K+ + EE G
Sbjct: 2301 ETSTESFQKEATLGSPKDTSPKRQDDCT-GSCSVA-------LAKETPTGLTEEAACDEG 2352
Query: 1204 TQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEG 1263
++ G+ A E S +ETK E +++ TD + ++ +G
Sbjct: 2353 QRTFGSSAHKTQTDSE---VQESTATSDETKALPLPEASVK-TDTGTESKPQGVIRSPQG 2408
Query: 1264 TQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQ 1323
+ A D E L D + VS + E + E + + K D+LE
Sbjct: 2409 LELALPSRDS--------EVLSAVADDSLAVSHKDSLEASPVLE--DNSSHKTPDSLEPS 2458
Query: 1324 SHAKSP------PSPVEREMVVQVEREKTEAEPTHVNEEKLEHET-AVTVSEEVSKQLLQ 1376
+SP SPVE +M K P+H +T +T V +LL+
Sbjct: 2459 PLKESPCRDSLESSPVEPKM-------KAGIFPSHFPLPAAVAKTELLTEVASVRSRLLR 2511
Query: 1377 TVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEE---KVLGE 1433
DG+ E SLE T + S ++ + + EE +V +
Sbjct: 2512 DP-----DGSAEDDSLEQ-------------TSLMESSGKSPLSPDTPSSEEVSYEVTPK 2553
Query: 1434 TANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTK 1493
T ++ T +PA H EE SE E P E+ + TK
Sbjct: 2554 TTDV----STPKPAVIHECAEEDDSENGEKKRFTPEEE---------------MFKMVTK 2594
Query: 1494 KGLSSDLEGEKTTSLKWKSDEVDEQVACQ---EVKVSVAIEDL------EPENGILELET 1544
+ +LE E +K + E+ + + SV +++ E E+G+ L T
Sbjct: 2595 IKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESGVPVLVT 2654
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSE--LQTQAHVIKADSQDAGQETEKEGEEPQ 1602
S+ V + ++ + + ++ A L E ++ Q S D+ E+ +P
Sbjct: 2655 SESRKVSSSSESE-PELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEVQFQPV 2713
Query: 1603 ASAQ---------DETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVND 1653
S Q E P S +E+ + + + +S + + S + + + + D
Sbjct: 2714 VSKQYTFKMNEDTQEEPGKSEEEKDSESHLAEDRHAVSTEAEDRSYDKLNRDTDQPKICD 2773
Query: 1654 QQLEEVVLPSEEEGG-GAGTKSVPEDD 1679
E + PS +G +S DD
Sbjct: 2774 GHGCEAMSPSSSAAPVSSGLQSPTGDD 2800
Score = 65.9 bits (159), Expect = 3e-10
Identities = 358/1817 (19%), Positives = 639/1817 (35%), Gaps = 373/1817 (20%)
Query: 74 LSLQEGDLNGQKGALNGQGALNS----------QEEEEVIVTEVGQRDSEDVS------- 116
LSLQ G L+G +L +G S Q E G ++ + S
Sbjct: 2191 LSLQSGALDGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPETSPESLSFS 2250
Query: 117 -KRDSDKEMATKSAVVHDITDD--GQEETPEIIEQIPSSESNLEELTQPTESQANDIGFK 173
K+ ++ TK + + T + ++E P + SE +T+ +E+ F+
Sbjct: 2251 PKKSEEQTGETKESTKTETTTEIRSEKEHPTTKDITGGSEERGATVTEDSETSTE--SFQ 2308
Query: 174 KVFKFVGFKFTVKKDKTEKPDTVQLLTVKK-----------DEGEGAAGAGDHKDPSLGA 222
K K T K + + + + K+ DEG+ G+ HK +
Sbjct: 2309 KEATLGSPKDTSPKRQDDCTGSCSVALAKETPTGLTEEAACDEGQRTFGSSAHKTQTDSE 2368
Query: 223 GEAASKESEPKQSTEKPEETLK-------------REQSHAEISPPAESGQAVEECKEEG 269
+ ++ S+ ++ PE ++K R E++ P+ + + ++
Sbjct: 2369 VQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSPQGLELALPSRDSEVLSAVADDS 2428
Query: 270 ---EEKQEKEPSKSAESPTSPVTSET--GSTFKKFFTQGWAGWRKKTSFRKPKEDEVEAS 324
K E S E +S T ++ S K+ P D +E+S
Sbjct: 2429 LAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKE----------------SPCRDSLESS 2472
Query: 325 EKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQ 384
+ + + + A VA +L +E A + + +P SAE + +E S +
Sbjct: 2473 PVEPKMKAGIFPSHFPLPAAVAKTEL-LTEVASVR--SRLLRDPDGSAEDDSLEQTSLME 2529
Query: 385 VSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVST-----VEERTEEQKTEVEETA 439
SG S + P+ EV E VST + E EE +E E
Sbjct: 2530 SSGKSPLSPDTPS---------SEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKK 2580
Query: 440 GSVPAEELVEM-------DAEPQEAEPAKELVK--LKETCVSGEDPTQGADLSPDEKVLS 490
P EE+ +M D QEA+ ++ K +E S DP + DE +
Sbjct: 2581 RFTPEEEMFKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHT 2640
Query: 491 KPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQV 550
E S V +L + E KV S S +L+ K KG G E Q
Sbjct: 2641 GSGED-ESGVPVLVTSESRKVSSS-------SESEPELAQLK-KGADSGLLPEPVIRVQP 2691
Query: 551 PADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPW 610
P+ P S + S SSPEE + + K + EE S+ EK
Sbjct: 2692 PSPLPSSMD------SNSSPEEVQFQPVVSKQYTFKMNEDTQEEPGKSEEEK-------- 2737
Query: 611 ASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPK 670
D E L + + A + E + +++ ++PK
Sbjct: 2738 -------------------DSESHLAEDRHAVSTEAEDRS---YDKLNRDTDQPK----- 2770
Query: 671 RKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGI-L 729
IC G + SS+ P + G D+ + + + L
Sbjct: 2771 ------------ICDGHGCEAMSPSSSA----APVSSGLQSPTGDDVDEQPVIYKESLAL 2814
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
G+ E D +A SP + ESF + S+ +E ED A S +
Sbjct: 2815 QGTHEKDTEGEELDVSRAESP---QADCPSESFSSSSSLPHCLVSEGKELDEDISATSSI 2871
Query: 790 EHSTPDTEPGK-EESWVSIKKFIPGRRKK---RPDGKQEQAPVEDAGPTGANEDDSDVPA 845
+ TE K +E++ ++ K P + + D PV D A D+ P
Sbjct: 2872 Q----KTEVTKTDETFENLPKDCPSQDSSITTQTDRFSMDVPVSDL----AENDEIYDPQ 2923
Query: 846 VVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATI 905
+ S Y+ V + + + K+ + S+ S + + V + + T+
Sbjct: 2924 IT--SPYENVPSQSFFSSEESKTQTDANHTTSFHSSEVYSVTITSPVEDVVVASSSSGTV 2981
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+ + S + ++ + + L E ++ + ++ PT++ E +
Sbjct: 2982 LSKE-----SNFEGQDIKMESQQESTLWE--MQSDSVSSSFEPTMSATTTVVGEQISKVI 3034
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTE----MVSAVSQLTDSPDTTEEATP 1021
+++ ++ ++ + +E EA EE + MV SQ T +PDTT TP
Sbjct: 3035 ITKTDVDSDSWSEIRE-----DDEAFEARVKEEEQKIFGLMVDRQSQGT-TPDTTPARTP 3088
Query: 1022 VQEVEGGVPDIEE-----QERRTQEVLQAVAEKVKEESQLPGTGG-------------PE 1063
+E G P E+ QE + E+ ++ A + + S + E
Sbjct: 3089 TEE---GTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRSYADESFHFFQIGQESREETLSE 3145
Query: 1064 DVLQPVQRAEAERPEEQAEASGLKK-------ETDVVLKVDAQEAKTEPFTQGKVVGQTT 1116
DV + A+ E AE+ L + E D++ ++E + P + ++ Q
Sbjct: 3146 DVKEGATGADPLPLETSAESLALSESKETVDDEADLLPDDVSEEVEEIPASDAQLNSQMG 3205
Query: 1117 PESFEKAP---QVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDG 1173
+ + P V+ + V T L+GVK Q PDS E + D
Sbjct: 3206 ISASTETPTKEAVSVGTKDLPTVQTGDIPPLSGVK-------QISCPDSSEPAVQVQLDF 3258
Query: 1174 STPVADF------DAPGTTQKDE--IVEIHEENEVASGTQSGGTEAEAVPAQKERP---P 1222
ST D+P ++ +++ ++EI A TE+++ + P P
Sbjct: 3259 STLTRSVYSDRGDDSPDSSPEEQKSVIEI----PTAPMENVPFTESKSKIPVRTMPTSTP 3314
Query: 1223 APSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFE 1282
AP S + E S ED L D+E + SK + Q +++ D
Sbjct: 3315 APPSAEY-----ESSVSEDFLSSVDEENKADEAKPKSKLP-VKVPLQRVEQQLSD----- 3363
Query: 1283 GLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVE 1342
L+ S+ + + + +A E+ DA L S K PV+ + E
Sbjct: 3364 -LDTSVQKTVAPQGQDMASIAPDNRSKSES-----DASSLDSKTK---CPVKTRSYTETE 3414
Query: 1343 REKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQ 1402
E E E+LE E+ E ++ + T +P + SS G P
Sbjct: 3415 TESRE------RAEELELES----EEGATRPKILTSRLP-VKSRSTTSSCRGGTSPTKES 3463
Query: 1403 EE----------AVCTKIQVQSSEASFTLTAAAEEEKVLG--ETANILETG--ETLEPAG 1448
+E +I ++S+ LT + E++++ E+++ LE E L P
Sbjct: 3464 KEHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEIVSDDESSSALEVSVIENLPP-- 3521
Query: 1449 AHLVLEEKSSEKNEDFAAHP-GEDAVPT---------GPDCQAKSTPVIVSATTKKGLSS 1498
+E + S + F P ++++ T G D + +
Sbjct: 3522 ----VETEHSVPEDIFDTRPIWDESIETLIERIPDENGHDHAEDPQDEQERIEERLAYIA 3577
Query: 1499 DLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLE---------------PENGILELE 1543
D G T L + D +EQ+ ++ +++D + ++E
Sbjct: 3578 DHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECL 3637
Query: 1544 TKSSKL-VQNIIQTAVD--------QFVRTEETAT-------EMLTSELQTQAHVIKADS 1587
TK +++ + ++++T + + E+T T +L EL T H K +
Sbjct: 3638 TKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEELCTAQHKQK-EE 3696
Query: 1588 QDAGQETEKEGEEPQASAQD--------ETPITSAKEESESTAV------GQAHSDISKD 1633
Q +E+E P S +D + + + +S +TA+ Q D S
Sbjct: 3697 QAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGK 3756
Query: 1634 MSEASEKTMT-------VEVEGSTVNDQQL------------EEVVLPSEEEGGGAGTKS 1674
M + E++ V G+ ++ Q EEV P+EEE T +
Sbjct: 3757 MQDLPEESSLEYQQEYFVTTPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPT 3816
Query: 1675 VPEDDGHALLAERIEKS 1691
E G ++ E E S
Sbjct: 3817 SSERGGSPIIQEPEEPS 3833
Score = 37.0 bits (84), Expect = 0.17
Identities = 162/868 (18%), Positives = 290/868 (33%), Gaps = 130/868 (14%)
Query: 968 EAELTPEAVTAAETAG--PLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
E E T +V + P+ A + +E +++ + LT + V+E+
Sbjct: 1478 ETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSIKVKEL 1537
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAER--------- 1076
V EE+ E+++ V E +++ +++ +G VQ + +ER
Sbjct: 1538 ---VKAAEEEPGEPFEIVERVKEDLEKVNEILRSGTCTRDESSVQSSRSERGLVEEEWVI 1594
Query: 1077 -PEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKV-------VGQTTPESFEKAPQVTE 1128
+E+ E + K ++ + E + + +GKV V T + P E
Sbjct: 1595 VSDEEIEEARQKAPLEIT-EYPCVEVRIDKEIKGKVEKDSTGLVNYLTDDLNTCVPLPKE 1653
Query: 1129 SIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
+++ + + E LA +S E + IPPD T S P P +
Sbjct: 1654 QLQTVQDKAGKKCEALAVGRSSEKEGKD-IPPDE----TQSTQKQHKPSLGIKKPVRRKL 1708
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDK 1248
E + EE G Q+ +AE E + E +E T
Sbjct: 1709 KEKQKQKEE-----GLQASAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETP- 1762
Query: 1249 EVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEG 1308
SI K + Q+ + + +P R K E K +
Sbjct: 1763 -----IGSIKDKVKALQKRVEDEQKGRSKLPI---------------RVKGKEDVPK-KT 1801
Query: 1309 TEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSE 1368
T +L+ + HA PSP KTE P K E + V+ S
Sbjct: 1802 THRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSA 1861
Query: 1369 EVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEE 1428
+ + + P +K SP TK + + S S T T
Sbjct: 1862 KTER------HSPASSSSKTEKHSPVSPS----------TKTE-RHSPVSSTKTERHPPV 1904
Query: 1429 KVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQA-KSTPVI 1487
G+T + + P+G +EK+ + E +P P + K PV
Sbjct: 1905 SPSGKT----DKRPPVSPSGR--------TEKHPPVSPGRTEKRLPVSPSGRTDKHQPVS 1952
Query: 1488 VSATTKKGL----SSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI--EDLEPENGILE 1541
+ T+K L S E + S K++ ++E ++ +E+ + + + + G+ E
Sbjct: 1953 TAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFE 2012
Query: 1542 LETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQT--------------QAHVIKADS 1587
++ K Q + V++ T E +E QT ++ S
Sbjct: 2013 HKSAKQKQPQEKGKVRVEKEKGPILTQREAQKTENQTIKRGQRLPVTGTAESKRGVRVSS 2072
Query: 1588 QDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVE 1647
+E G+E S + P+ S EE S++ K+ + M +++
Sbjct: 2073 IGVKKEDAAGGKEKVLSHKIPEPVQSVPEEES-----HRESEVPKEKMADEQGDMDLQIS 2127
Query: 1648 GSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDE------KG 1701
EV+ E+ + E+ A L +++ L P K
Sbjct: 2128 PDRKTSTDFSEVIKQELEDNDKYQQFRLSEETEKAQL--HLDQVLTSPFNTTFPLDYMKD 2185
Query: 1702 DDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVH--------- 1752
+ + Q+ AL D S K P E ++ +E H
Sbjct: 2186 EFLPALSLQSGAL---DGSSESLKNEGVAGSPCGSLMEGTPQISSEESYKHEGLAETPET 2242
Query: 1753 SESDKAITPQAQEELQKQERESAKSELT 1780
S + +P+ EE + +ES K+E T
Sbjct: 2243 SPESLSFSPKKSEEQTGETKESTKTETT 2270
>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis critical
region 1 [Homo sapiens]
Length = 1400
Score = 80.9 bits (198), Expect = 1e-14
Identities = 218/1167 (18%), Positives = 391/1167 (33%), Gaps = 168/1167 (14%)
Query: 214 DHKDPSLGAGEAASKESEP----KQSTEKPEETLKREQSHAE--ISPPAESGQAVEEC-- 265
+H+ P ++++ +P ++S + + T ++S + I+P +S +
Sbjct: 176 NHEAPPTSEENSSNQGKDPMIRNQRSVDPADSTTTHKESAGKKHITPAPKSKINCRKSTT 235
Query: 266 -KEEGEEKQEK--EPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVE 322
K K +K P + + S ++ + T F G + ++K++ K
Sbjct: 236 GKSTVTRKSDKTGRPLEKSMSTLDKTSTSSHKTTTSFHNSGNSQTKQKSTSFPEKITAAS 295
Query: 323 ASEKKKEQEPEKVDTEEDGKAEVASEKL------------------------------TA 352
+ K PE+ + ED + VAS+KL TA
Sbjct: 296 KTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQETISANELTQSLAEPTEHGGRTA 355
Query: 353 SEQ--AHPQEPAE----SAHEPRLSAEYEKVE----LPSEEQVSGSQGPSE--EKPAPLA 400
+E P EP E +A+E + E E +E GP+E E A
Sbjct: 356 NENNTPSPAEPTENRERTANENTTLSPAEPTENRERTANENTAPFPAGPTENREMTANEN 415
Query: 401 TEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE--------------- 445
T +F + H E E + E TE + E PAE
Sbjct: 416 TTLFPAEPTEHGERTANENTTPSPAEPTEHGERTANENTTPSPAEPTEHGERTPFANDKT 475
Query: 446 --------------ELVEMDAEPQEAEPA--KELVKLKETCVSGEDPTQGADLSPDEKVL 489
L + P AEP +E + T S PT+ + + +EK
Sbjct: 476 TSSSAESTEHGERTPLANENTTPSPAEPTENRERTANENTTPSPAGPTENRETTANEKTT 535
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
P V E + K SP + T G + ++ E GE T
Sbjct: 536 LSP----VEPTENRETTANEKTTPSPAEP--TENGQRTPFANEKTTSSSAEPTEHGERTP 589
Query: 550 V--------PADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGE 601
+ PA+ +++E E + SP EP E E AE T +G+
Sbjct: 590 LANENTTPSPAEPTENRERTANEKTTPSPAEPTENGDRTPLANEKTTPSLAE--PTENGQ 647
Query: 602 KKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSV 661
+ TP+A+ +K +E + +E + + + + + +E +E
Sbjct: 648 R-----TPFAN-------EKTTSSSAEPTEHEERTPLANENTTPSPAEPTENRERTANEN 695
Query: 662 EEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDK 721
P P P + + + + + + R ++ P + Q+ A +K
Sbjct: 696 TTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFA-NEK 754
Query: 722 ETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSE 781
T + E P ++ PTE + E TP ++ E++
Sbjct: 755 TTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEK----TTPFPAEPTENRERTA 810
Query: 782 DSIAGSGVEHSTPD----TEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGAN 837
+ E++TP TE G + + ++ +K P + +GK + P + T ++
Sbjct: 811 N-------ENTTPSPAQPTENG-DRTPLANEKTTPSLAEPTENGK--RTPFANEKTTSSS 860
Query: 838 EDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVA 897
+ ++ PL+ + + +++A + + E ++ + A
Sbjct: 861 AEPTEHAERTPLANENTTSSPAEPTENRERTANEKTTQFPAEPTENRESTANEKTTPFPA 920
Query: 898 DGTRAATIIEERSPSWISASVTEPLEQVEAE--AALLTEEVLE---REVIAEEEPPTVTE 952
+ T E R + + P E E E L+ +E L+ R+ E P +
Sbjct: 921 EPT------ENREWTANENTTLSPAEPTEHEEMTPLMVDENLQAPFRQGSCAERPKDICA 974
Query: 953 PLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDS 1012
+ T SE+ E +T++ T T +S A E T +A+ + +
Sbjct: 975 TV-------ASTTGSESSTASEIITSS-TMSVSATASSTASSTASEITMSSAAIPVSSTA 1026
Query: 1013 PDTTEEATPVQE-VEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQR 1071
+T +T V E V + +E T + V T G ++
Sbjct: 1027 YETIRFSTAVSEPVTASILALESTLAFTTVSNTTTSSTVTSVPTTASTSGSKN----TTA 1082
Query: 1072 AEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIE 1131
EA E A ++T V + A++ P T K TT S ++
Sbjct: 1083 CEATMSETTIAAITASEDTTVSTQTSVIAAESVPHTATKTPTDTTTASVSATVPKNNTLS 1142
Query: 1132 SSELVTTCQAETLAGVKSQEMVMEQAIPPDSVET--PTDSETDGSTPVADFDAPGTTQKD 1189
V T T S+ M S T PT T S A + P + D
Sbjct: 1143 ----VITSTPSTAPNTASKTMTTASKTTTTSTITSLPTTVFTTTSKITAGSEIPTASTTD 1198
Query: 1190 EIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKE 1249
A T++ GT E+ P+ PA ++ T + E+T HT
Sbjct: 1199 SAT-------TAISTKASGTTVESAPSTAPPTPAETTTASVPTTTSTTGSENTGHHTVSS 1251
Query: 1250 VSVETVSILSKTEGTQEADQYADEKTK 1276
V + S++ E + + T+
Sbjct: 1252 VPTTVFATASESSTGSETTRASTSATE 1278
Score = 58.5 bits (140), Expect = 6e-08
Identities = 122/584 (20%), Positives = 200/584 (34%), Gaps = 54/584 (9%)
Query: 940 EVIAEEEPPTVTEPLPENREARGD---TVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 996
++ A + T PE E D TV S+ LT ET + A E T++ A
Sbjct: 290 KITAASKTTYKTTGTPEESEKTEDSRTTVASDKLLTKTTKNIQET---ISANELTQSLA- 345
Query: 997 EETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQL 1056
E TE + ++P +P + E E + E+ E+
Sbjct: 346 -EPTEHGGRTANENNTP------SPAEPTENRERTANENTTLSPAEPTENRERTANENTA 398
Query: 1057 PGTGGPEDVLQPVQRAEAE----RPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVV 1112
P GP + + P E E + + T + EP G+
Sbjct: 399 PFPAGPTENREMTANENTTLFPAEPTEHGERTANENTTP---------SPAEPTEHGERT 449
Query: 1113 GQ--TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP---- 1166
TTP E + +++ T+ AE+ + + E P + T
Sbjct: 450 ANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPTENRER 509
Query: 1167 TDSETDGSTPVADFDAPGTTQKDEI----VEIHEENEVASGTQSGGTEAEAVPAQKERPP 1222
T +E +P + TT ++ VE E E + ++ + AE + P
Sbjct: 510 TANENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENGQRTP- 568
Query: 1223 APSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFE 1282
F E S E T EH ++ + S E T+ ++ A+EKT P E
Sbjct: 569 ------FANEKTTSSSAEPT-EHGERTPLANENTTPSPAEPTENRERTANEKTTPSPA-E 620
Query: 1283 GLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVE 1342
E T + + EK T E TE + + S + P ER +
Sbjct: 621 PTENGDRTPL--ANEKTTPSL--AEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANEN 676
Query: 1343 REKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQ 1402
+ AEPT E T + + + + + A+ + E +
Sbjct: 677 TTPSPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTS 736
Query: 1403 EEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNE 1462
A T+ ++ A+ T+++ E GE + TL PAG E ++EK
Sbjct: 737 SPAEPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAGPTENRERTANEKTT 796
Query: 1463 DFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTT 1506
F A P E+ T + +T + T+ G + L EKTT
Sbjct: 797 PFPAEPTENRERTANE----NTTPSPAQPTENGDRTPLANEKTT 836
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 80.5 bits (197), Expect = 1e-14
Identities = 360/1817 (19%), Positives = 632/1817 (34%), Gaps = 243/1817 (13%)
Query: 17 EGSSTPAEPEPSGGGPSAEAAP--------DTTADPAIAASDPATK---LLQKNGQ-LST 64
E S+ A E S S A+ DT+ D + D A K G+ L T
Sbjct: 214 EASAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLET 273
Query: 65 INGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIV-----TEVGQR--DSEDVSK 117
E +L ++ N LN ++E T+ G++ DS + +
Sbjct: 274 APKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGE 333
Query: 118 RDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDI----GFK 173
R +K+ T+ H E+T ++ ++ + E +E L P+E +N G K
Sbjct: 334 RKKEKKEKTEKKFDHS---KKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTK 390
Query: 174 KVFKFVGFKFTVKKDKT-EKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAG-EAASKESE 231
+ F + D T T L + ++D E + ++ + + E +K+++
Sbjct: 391 EDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNK 450
Query: 232 PKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSE 291
K T E + HA + P + + +E +Q ++ S + E + +
Sbjct: 451 TKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQ-SIAKEKEERLLRRQ 509
Query: 292 TGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLT 351
R+K ++ ++ E S K K Q VD EE + +
Sbjct: 510 IN--------------REKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAAR 555
Query: 352 ASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVH 411
E ++ E + LS + +K EE Q E+ L T EK ++
Sbjct: 556 IKEVLKERKVLEK--KVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKIS 613
Query: 412 QEEVVAEVHVST---------------VEERTEEQKTEVE-ETAGSVPAEELVEMDAEPQ 455
+ + VH + V+E E K E E + S P ++E E
Sbjct: 614 SSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPV--IMEGVQEET 671
Query: 456 EAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSP 515
+ K V+ E C E+P + +EK L K SE L S + +V+ S
Sbjct: 672 DTRDVKRQVERSEICT--EEPQKQKSTLKNEKHLKKDD----SETPHLKSLLKKEVKSSK 725
Query: 516 LKKLFTSTGLK-KLSGK-KQKGK--RGGGDEESGEHTQVPADSPDSQEEQKGESSASSPE 571
K T + KLS K K KG GDE ++ ++ ++Q ++ SS +
Sbjct: 726 EKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDD 785
Query: 572 EPEEITCL--EKGLAEVQQDGE--------AEEGATSDGEKKREGVTPWASFKKMVTPKK 621
+ E + E+ L+ + +DG+ +E + KK ++ + K K
Sbjct: 786 KTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLS---AEKTKAEHKS 842
Query: 622 RVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEP--KPEE---PKRKVDTS 676
R S+ K+ K TL + SE + +M + + KPEE +++ S
Sbjct: 843 RRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKS 902
Query: 677 VSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHD 736
+ E L+ SK + ++ + E G ++A DKE T+ + Q
Sbjct: 903 LLEEKLVLKSKSKTQGKQVKVVETE----LQEGATKQATTPKPDKEKNTEENDSEKQRKS 958
Query: 737 PGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK-SKLEEKSEDSIAGSGVEHSTPD 795
+ E P S+ S ++ + R K +K + KS+ + +E D
Sbjct: 959 KVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSD 1018
Query: 796 TEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAV 855
K S K I KK+ + K DD D V E
Sbjct: 1019 GH--KSRSLKHSSKDI----KKKDENKS---------------DDKDGKEVDSSHEKARG 1057
Query: 856 EREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS 915
ME + +++ E +S+E+++ + + A ++ + ++ ++S
Sbjct: 1058 NSSLMEKKLSRRLCENRRGS----LSQEMAKGEEKLAANTLSTPSGSSLQRPKKSGDMTL 1113
Query: 916 ASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLP-ENREARGDTVVSEAELTPE 974
EP+E +++E + E V E + + + EN + + V + EL
Sbjct: 1114 IPEQEPME-IDSEPGV--ENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTC 1170
Query: 975 AVTAAETAGPLGAEEGTEASA-AEETTEMVSAVSQLTDSPDTTEEATPVQE--VEGGVPD 1031
+ TA GT ++ +E+ + S +++ + P ++ + G +
Sbjct: 1171 TADSKATAPAYKPGRGTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRGTTE 1230
Query: 1032 IE-EQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKET 1090
+ + E + +L A +E + + L T E V Q A E + L T
Sbjct: 1231 VNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQG--DATLEHSTNLDSSPSLSSVT 1288
Query: 1091 DVVLKVDAQEAKTEPFTQGKVV-----GQTTPESFEKAPQVTESIESSELVTTCQAETLA 1145
V L+ ++ + P + V T+P P + ++ SE++ T
Sbjct: 1289 VVPLR-ESYDPDVIPLFDKRTVLEGSTASTSPADHSALPNQSLTVRESEVLKT------- 1340
Query: 1146 GVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGT-TQKDEIVEIHEENEVASGT 1204
+DS+ G D A + T K I E H+ + G
Sbjct: 1341 ---------------------SDSKEGGEGFTVDTPAKASITSKRHIPEAHQAT-LLDGK 1378
Query: 1205 QSG-----GTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILS 1259
Q G++ V + E V + + E L+ T K +VE
Sbjct: 1379 QGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIK-ATVEN----G 1433
Query: 1260 KTEGTQ-------EADQYADE---KTKDVPFFEGLEGSI-DTGITVSREKVTEVALKGEG 1308
K +G ++YA+ K K P G + D I V R G
Sbjct: 1434 KKDGIAVDHVVGLNTEKYAETVKLKHKRSP------GKVKDISIDVERRNENSEVDTSAG 1487
Query: 1309 TEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSE 1368
+ A + P E+ V TE + V ++ A T S
Sbjct: 1488 SGSAPSVLHQRNGQTEDVATGPRRAEKTSVAT----STEGKDKDVTLSPVKAGPATTTSS 1543
Query: 1369 EV--SKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAE 1426
E S+ L ++ +G + + + P +G E + CT + AE
Sbjct: 1544 ETRQSEVALPCTSIEADEGLI-IGTHSRNNPLHVGAEASECTVFAAAEEGGAVVTEGFAE 1602
Query: 1427 EEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPV 1486
E L T + GE+ E A A E + A H + +
Sbjct: 1603 SETFLTST----KEGESGECAVA-----ESEDRAADLLAVHAVKIEANVNSVVTEEKDDA 1653
Query: 1487 IVSATTKK----GLSSD---LEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGI 1539
+ SA +++ LS D +EG T + +SD + S++ E+++ G
Sbjct: 1654 VTSAGSEEKCDGSLSRDSEIVEGTITFISEVESDGAVTSAGTEIRAGSISSEEVDGSQGN 1713
Query: 1540 LELETKSSKLVQNIIQTAV----DQFVRTEETATEMLTSELQTQAHVIKADSQ-DAGQET 1594
+ + + T D FV T + T A V+ D+ G
Sbjct: 1714 MMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPPGTSA 1773
Query: 1595 EKEGEEPQASAQDETPITSAKEESESTAVGQAHSDI--SKDMSEASEKTMTVEVEGSTVN 1652
+EG+ S D T SA + T G+ + S+D SE + E G +
Sbjct: 1774 SQEGD---GSVNDGTEGESAVTSTGITEDGEGPASCTGSEDSSEGFAISSESEENGESAM 1830
Query: 1653 DQQL--EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQ 1710
D + E +P G P DD E I S +EDE+G+DV +
Sbjct: 1831 DSTVAKEGTNVPLVAAG--------PCDD------EGIVTSTGAKEEDEEGEDVVTSTGR 1876
Query: 1711 NSALADTDASGGLTKES 1727
+ + GL +ES
Sbjct: 1877 GNEIGHASTCTGLGEES 1893
Score = 80.1 bits (196), Expect = 2e-14
Identities = 356/1856 (19%), Positives = 668/1856 (35%), Gaps = 256/1856 (13%)
Query: 4 GSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLS 63
GS E+P T P P GPSA A D + L
Sbjct: 168 GSGNTAPDDEKPDTSLITQGVPTP---GPSANVANDAMSI------------------LE 206
Query: 64 TINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKE 123
TI + ++ + + + K + L SQ + + +R SED++ DKE
Sbjct: 207 TITSLNQEASAARASTETSNAKTSERASKKLPSQPTTDTSTDK--ERTSEDMA----DKE 260
Query: 124 MATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKF 183
+T D +G E P+ E+ +EE+ T+ N I K + +
Sbjct: 261 KSTA-----DSGGEGLETAPKS-EEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQ 314
Query: 184 TVKK-DKTEK-PDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEE 241
K DK EK PD+ + KK++ E DH S E K + KQ+ EK E
Sbjct: 315 KNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKS----EDTQKVKDEKQAKEKEVE 370
Query: 242 TLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFT 301
+LK P+E K + K + + S V T T T
Sbjct: 371 SLKL---------PSE--------KNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHT 413
Query: 302 QGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEP 361
+ SF + E+EV S+ +E E D E++ + + ++ +SE
Sbjct: 414 SDLS------SFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVR 467
Query: 362 AESAHEPRLSAEYEKVELPSEEQVSGSQG----PSEEKPAPLATEVFDEKIEVHQEEVVA 417
H+P L Y K S+++++ Q E++ L ++ EK+E +++
Sbjct: 468 HAYVHKPYL---YSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKA- 523
Query: 418 EVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVK-----LKETCVS 472
E+T+ KT+ + SV EE EP+ A KE++K K+ +S
Sbjct: 524 --------EKTKSSKTK-GQGRSSVDLEESSTKSLEPKAAR-IKEVLKERKVLEKKVALS 573
Query: 473 GEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKK 532
+ ++ + K K + E L + E + + K+ +S LK + K
Sbjct: 574 KKRKKDSRNVEENSK---KKQQYEEDSKETLKTSEHCEKE-----KISSSKELKHVHAKS 625
Query: 533 QKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEA 592
+ K ES V + +S+ E++ + S+P E + E +V++ E
Sbjct: 626 EPSKPARRLSESLH--VVDENKNESKLEREHKRRTSTPVIMEGVQ-EETDTRDVKRQVER 682
Query: 593 EEGATSDGEKKREGVTPWASFKK--MVTP--KKRVRRPSESDKE-DELDKVKSATLSSTE 647
E T + +K++ + KK TP K +++ +S KE E +K S S +
Sbjct: 683 SEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVK 742
Query: 648 STASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAM 707
G E E KV+ ++ K+ + SSD++ K+
Sbjct: 743 HKYKGDCMHKTGDETELHSSEKGLKVEENI----------QKQSQQTKLSSDDKTERKSK 792
Query: 708 GGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRL-- 765
+ +K GKD + ++ I+ + + T+ E S S ++
Sbjct: 793 HRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK 852
Query: 766 ---------VTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVS--IKKFIPGR 814
+T +++S+S E+K D + + + P+ KE+ +++ + +
Sbjct: 853 DSLGSKQHGITLQRRSESYSEDKC-DMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLVLK 911
Query: 815 RKKRPDGKQ---EQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQ 871
K + GKQ + +++ A D ++ + + K+E + +++ +
Sbjct: 912 SKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVE 971
Query: 872 PEQKAATEVSKELSESQVHMMAAAVA------DGTRAATIIEER-SPSWISASVTEPLEQ 924
P + A+ + + H +A D +T +E + S S S+ +
Sbjct: 972 PVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKD 1031
Query: 925 VEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAE--TA 982
++ + +++ +EV + E L E + +R L+ E E A
Sbjct: 1032 IKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAA 1091
Query: 983 GPLGAEEGTEASAAEETTEMVSAVSQ---LTDSPDTTEEATPVQEVEGGVPDIEEQERRT 1039
L G+ +++ +M Q DS E V + + + +Q+ +
Sbjct: 1092 NTLSTPSGSSLQRPKKSGDMTLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDS 1151
Query: 1040 QEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQ 1099
+ + Q + V+++ T + + +E + T + K+ Q
Sbjct: 1152 ENMKQKTSATVQKDELRTCTADSKATAPAYKPGRGTGVNSNSEKHADHRST-LTKKMHIQ 1210
Query: 1100 EA-------KTEPFTQG----KVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVK 1148
A + EP +G + +T AP + ++ + T + G
Sbjct: 1211 SAVSKMNPGEKEPIHRGTTEVNIDSETVHRMLLSAPSENDRVQKNLKNTAAEEHVAQG-- 1268
Query: 1149 SQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGG 1208
+ +E + DS +P+ S P+ + P +++ + ++ V G
Sbjct: 1269 --DATLEHSTNLDS--SPSLSSVT-VVPLRESYDP------DVIPLFDKRTVLE-----G 1312
Query: 1209 TEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEAD 1268
+ A PA P S V + E + S ++ E + + SI SK EA
Sbjct: 1313 STASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAK-ASITSKRH-IPEAH 1370
Query: 1269 QYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKS 1328
Q K L GS TG+ V E +T+ EG KK++ L + + K
Sbjct: 1371 QATLLDGKQGKVIMPL-GSKLTGVIVENENITK-----EGGLVDMAKKENDLNAEPNLKQ 1424
Query: 1329 P-PSPVER--------EMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVN 1379
+ VE + VV + EK + KL+H+ + +++S + +
Sbjct: 1425 TIKATVENGKKDGIAVDHVVGLNTEK------YAETVKLKHKRSPGKVKDISIDVERRNE 1478
Query: 1380 VPIIDGAKEVSSLEGSPPPCL----GQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETA 1435
+D S+ GS P L GQ E V T + + T T +++ L
Sbjct: 1479 NSEVD----TSAGSGSAPSVLHQRNGQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVK 1534
Query: 1436 NILETGETLEPAGAHLVLEEKSSEKNEDF---------AAHPGEDAVPTGPDCQAKSTPV 1486
T + E + + L S E +E H G +A A+
Sbjct: 1535 AGPATTTSSETRQSEVALPCTSIEADEGLIIGTHSRNNPLHVGAEASECTVFAAAEEGGA 1594
Query: 1487 IVS---ATTKKGLSSDLEGEK-TTSLKWKSDEVDEQVACQEVKVSVAIEDL---EPENGI 1539
+V+ A ++ L+S EGE ++ D + +A VK+ + + E ++ +
Sbjct: 1595 VVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKDDAV 1654
Query: 1540 LELE---------TKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDA 1590
++ S++V+ I F+ E+ + ++ + +A I ++ D
Sbjct: 1655 TSAGSEEKCDGSLSRDSEIVEGTI-----TFISEVESDGAVTSAGTEIRAGSISSEEVDG 1709
Query: 1591 --------GQETEKEGEEPQASAQDET------PITSA--KEESESTAVGQAHSDISKDM 1634
G + E EG A+ + +T A +EE T G D
Sbjct: 1710 SQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVTGAGVVLGDNDAPP 1769
Query: 1635 SEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVE 1694
++ + V T + + + + EG + T S +G A+ +E E
Sbjct: 1770 GTSASQEGDGSVNDGTEGESAVTSTGITEDGEGPASCTGSEDSSEGFAISSES------E 1823
Query: 1695 PKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGK 1750
+ D E N L A+G E T+ ++E E+ ++V G+
Sbjct: 1824 ENGESAMDSTVAKEGTNVPLV---AAGPCDDEGIVTSTGAKEEDEEGEDVVTSTGR 1876
Score = 69.3 bits (168), Expect = 3e-11
Identities = 186/896 (20%), Positives = 347/896 (38%), Gaps = 142/896 (15%)
Query: 944 EEEPPT--VTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTE 1001
+E+P T +T+ +P T A + +A++ ET L E ASAA +TE
Sbjct: 176 DEKPDTSLITQGVP--------TPGPSANVANDAMSILETITSLNQE----ASAARASTE 223
Query: 1002 MVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGG 1061
T + T+E A+ + ++ER ++++ A+K K + G G
Sbjct: 224 --------TSNAKTSERASKKLPSQPTTDTSTDKERTSEDM----ADKEKSTADSGGEG- 270
Query: 1062 PEDVLQPVQRAE--AERPEEQAEASGLKKETD--VVLKVDAQEAKTEPFTQGKVVGQTTP 1117
L+ ++E ++ P E KE + ++L D Q+ +E + G+ P
Sbjct: 271 ----LETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKP 326
Query: 1118 ESFEKAPQVTESIESSE--LVTTCQAETLAGVKSQEMVMEQAIPPDSVETPT-------- 1167
+S EK + E E +E + ++E VK ++ E+ + +S++ P+
Sbjct: 327 DSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV--ESLKLPSEKNSNKAK 384
Query: 1168 ------------DSETDGSTPV-------ADFDAPGTTQKDEIV--EIHEENEVASGTQ- 1205
DS+ DG T + +D + ++E+V + EE E+ S +
Sbjct: 385 TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEE 444
Query: 1206 --------------SGGTEAEAVPAQKERPPAPSSFVF---QEETKEQSKMEDTLEHTDK 1248
S G A +P S + E T EQ + E ++
Sbjct: 445 KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER 504
Query: 1249 EVSVETVSILSKTEGTQEADQYADEKTK-----DVPFFEGLEGSIDTGITVSREKVTEVA 1303
+ + + + Q+A++ KTK V E S++ +E + E
Sbjct: 505 LLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLKERK 564
Query: 1304 LKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETA 1363
+ + ++ +K D+ ++ ++K E E E E ++E L+H A
Sbjct: 565 VLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKE-LKHVHA 623
Query: 1364 VTVSEEVSKQLLQTVNVPIIDGAKEVSSLE-------GSPPPCLGQEEAVCTKIQVQSSE 1416
+ + +++L ++++V +D K S LE +P G +E T+ + E
Sbjct: 624 KSEPSKPARRLSESLHV--VDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVE 681
Query: 1417 ASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEE-KSSEKNEDFAAHPGEDAVPT 1475
S T +++K + L+ ++ P L+ +E KSS++ + P ED +
Sbjct: 682 RSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSV 741
Query: 1476 ----GPDCQAKSTPVIVSATTKKGLSSDLEGEK-TTSLKWKSDEVDEQVA--CQEVKVSV 1528
DC K+ +++KGL + +K + K SD+ E+ + E K+SV
Sbjct: 742 KHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNERKLSV 801
Query: 1529 AIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+D +P + + II+T D+ VR E E S +T+A S
Sbjct: 802 LGKDGKP-------------VSEYIIKT--DENVRKENNKKERRLSAEKTKAEHKSRRSS 846
Query: 1589 DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEG 1648
D+ + + G + + + SES + + D S +M + V E
Sbjct: 847 DSKIQKDSLGSKQHG--------ITLQRRSESYSEDKCDMD-STNMDSNLKPEEVVHKEK 897
Query: 1649 STVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKED-EKGDDVDDP 1707
E++VL S+ + G K V + L E K PK D EK + +D
Sbjct: 898 RRTKSLLEEKLVLKSKSKTQGKQVKVVETE-----LQEGATKQATTPKPDKEKNTEENDS 952
Query: 1708 ENQNSALADT---DASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAIT 1760
E Q + + + +G ++ +K+ + +L K +SDK T
Sbjct: 953 EKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDST 1008
Score = 50.1 bits (118), Expect = 2e-05
Identities = 210/1044 (20%), Positives = 356/1044 (34%), Gaps = 166/1044 (15%)
Query: 235 STEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGS 294
+TEK ET+K + SP +++ E E E + S + S S + G
Sbjct: 1447 NTEKYAETVKLKHKR---SPGKVKDISIDV--ERRNENSEVDTSAGSGSAPSVLHQRNGQ 1501
Query: 295 TFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASE 354
T T R+ ++ V S + K+++ + + G A S + SE
Sbjct: 1502 TEDV-----------ATGPRRAEKTSVATSTEGKDKDVT-LSPVKAGPATTTSSETRQSE 1549
Query: 355 QAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEE 414
A P E+ E + G+ S P + E + + EE
Sbjct: 1550 VALPCTSIEA----------------DEGLIIGTH--SRNNPLHVGAEASECTVFAAAEE 1591
Query: 415 VVAEVHVSTVEERTEEQKTEVEETAGSVPAE------ELVEMDAEPQEAEPAKELVKLKE 468
A V E T T+ E+ AE +L+ + A EA + + K+
Sbjct: 1592 GGAVVTEGFAESETFLTSTKEGESGECAVAESEDRAADLLAVHAVKIEANVNSVVTEEKD 1651
Query: 469 TCVSGEDPTQGAD--LSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLK 526
V+ + D LS D +++ EG ++ + + S + G+ ++ S +
Sbjct: 1652 DAVTSAGSEEKCDGSLSRDSEIV----EGTITFISEVESDGAVTSAGTEIRA--GSISSE 1705
Query: 527 KLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEV 586
++ G + R G +E+ S + + P E +T G V
Sbjct: 1706 EVDGSQGNMMRMGPKKETEGTVTCTGAEGRSDNFVICSVTGAGPREERMVT----GAGVV 1761
Query: 587 QQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSST 646
D +A G TS ++ V + VT D E S S
Sbjct: 1762 LGDNDAPPG-TSASQEGDGSVNDGTEGESAVTSTGITE-----DGEGPASCTGSEDSSEG 1815
Query: 647 ESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKA 706
+ +SE +E + +++ +E T+V L+ G D+EG +
Sbjct: 1816 FAISSESEENGESAMDSTVAKE-----GTNVP---LVAAGPC----------DDEGIVTS 1857
Query: 707 MGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES----- 761
G + DE G+D T T + ++ G S+ G E EGV ES
Sbjct: 1858 TGAKEE--DEEGEDVVTST------GRGNEIGHASTC---TGLGEESEGVLICESAEGDS 1906
Query: 762 -----FKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWV--SIKKFIPGR 814
+ + + E + DS++G TE G +++ + S K +
Sbjct: 1907 QIGTVVEHVEAEAGAAIMNANENNVDSMSG---------TEKGSKDTDICSSAKGIVESS 1957
Query: 815 RKKRPDGKQEQAPVEDA--GP-TGANEDDSD----------VPAVVPLSEYDA-VEREKM 860
GK E PV GP T A D SD + + YD V E
Sbjct: 1958 VTSAVSGKDEVTPVPGGCEGPMTSAASDQSDSQLEKVEDTTISTGLVGGSYDVLVSGEVP 2017
Query: 861 EAQQAQKS-AEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWI----S 915
E + A S +E+ ++ T V E E M A D T ++ ++ + +
Sbjct: 2018 ECEVAHTSPSEKEDEDIITSVENE--ECDGLMATTASGDITNQNSLAGGKNQGKVLIIST 2075
Query: 916 ASVTEPLEQVEA--------EAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVS 967
++ + QV A AL TEE +E + EE P+P GD
Sbjct: 2076 STTNDYTPQVSAITDVEGGLSDALRTEENMEGTRVTTEE---FEAPMPS--AVSGDDSQL 2130
Query: 968 EAELTPEAVTAAETAGPLGAE------EGTEASAAEETTEMVSAVSQLTDSPDTTEEATP 1021
A + E A + +G E T AE + +AV + P A
Sbjct: 2131 TASRSEEKDECAMISTSIGEEFELPISSATTIKCAESLQPVAAAVEERATGPVLISTA-- 2188
Query: 1022 VQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQA 1081
+ EG +P + + L + +++ K+E L T E+ V E E+A
Sbjct: 2189 --DFEGPMPSAPPE---AESPLASTSKEEKDECALISTSIAEECEASVSGVVVESENERA 2243
Query: 1082 EASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQA 1141
+K+ ++ + E P V P+ E P VT + E + T
Sbjct: 2244 GTVMEEKDGSGIISTSSVEDCEGP------VSSAVPQE-EGDPSVTPAEEMGD---TAMI 2293
Query: 1142 ETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVA 1201
T + +++ + + T T E + ++ HEEN++
Sbjct: 2294 STSTSEGCEAVMIGAVLQDEDRLTITRVEDLSDAAIISTSTAECMPISASIDRHEENQLT 2353
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPS 1225
+ G + A K + P PS
Sbjct: 2354 ADNPEGNGDLSATEVSKHKVPMPS 2377
Score = 48.1 bits (113), Expect = 7e-05
Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 48/244 (19%)
Query: 63 STINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDK 122
+T + E+DE S E G+K N + SQEE++ I+ + KR +
Sbjct: 2831 TTSRVMEEKDEYSSSE--TTGEKPEQNDDDTIKSQEEDQPIIIK---------RKRGRPR 2879
Query: 123 EMATKSAVVHDITDDGQEETPEI-IEQIPSS---------ESNLEELTQPTESQANDIGF 172
+ ++ + + DD + +T + +EQ PSS ESN E S +ND G
Sbjct: 2880 KYPVETTL--KMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGE 2937
Query: 173 KKVFKFVGFK-------FTVKKD-KTEKPDTVQLLTV------KKDEGEGAAGAGDHKDP 218
+K+ V + TV D ++ +P+ + +V KK++ + +D
Sbjct: 2938 EKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDE 2997
Query: 219 SLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPS 278
GA ++ SE ++S + ++KR++ E+SPP + G+++ E+ P
Sbjct: 2998 PSGATTRSTTRSEAQRSKTQLSPSIKRKR---EVSPPG--------ARTRGQQRVEEAPV 3046
Query: 279 KSAE 282
K A+
Sbjct: 3047 KKAK 3050
Score = 41.6 bits (96), Expect = 0.007
Identities = 137/685 (20%), Positives = 234/685 (34%), Gaps = 128/685 (18%)
Query: 198 LLTVKKDEGEGAAGAGDHKDPSLGAGE--AASKESEPKQSTEKPEETLKREQSHAEISPP 255
+L V +EG G HK PS G G A E E K E PE I P
Sbjct: 2399 VLAVSTEEGHN--GPSVHK-PSAGQGHPSAVCAEKEEKHGKECPE-----------IGPF 2444
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A GQ E++ + + SP T G + ++ G S
Sbjct: 2445 AGRGQKESTLHLINAEEKNVLLNSLQKEDKSPETGTAGGSSTASYSAGRGLEGNANSPAH 2504
Query: 316 PKEDEVEASEKKKEQEPE------------KVDTEEDGKAEVASEKLTASEQAHPQEPAE 363
+ E + + K+ K D + VA +EQ ++ +
Sbjct: 2505 LRGPEQTSGQTAKDPSVSIRYLAAVNTGAIKADDMPPVQGTVAEHSFLPAEQQGSEDNLK 2564
Query: 364 SAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVST 423
++ ++ + K+ PS + PA + + K E Q+ + +
Sbjct: 2565 TSTTKCITGQESKIA-PSHTMIP---------PATYSVALLAPKCE--QDLTIKNDYSGK 2612
Query: 424 VEERTEEQKT-EVEETAGSVPAEE--LVEMDAEPQ------EAEPAKELVKLK------- 467
++ +KT + T S P E +V + +E E P L LK
Sbjct: 2613 WTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDIGNEESPLNVLGGLKLKANLKM 2672
Query: 468 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVS-EVEMLSSQERMKVQGSPLKKLFTSTGLK 526
E V E+ G L+P E + P G+ + E L E + V+ S +
Sbjct: 2673 EAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSES 2732
Query: 527 KLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKG-------ESSASSPEEPEEIT-C 578
G+ G++ + SG V AD + +EE++ + SS +EP++
Sbjct: 2733 YNKGEISSGRKDNAEAISGH--SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDV 2790
Query: 579 LEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKV 638
L+ + Q+ E + E R+ +EL K
Sbjct: 2791 LDSRIETAQRQCPETEPHDTKEENSRD--------------------------LEELPKT 2824
Query: 639 KSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSS 698
S T S+T M+E+ + S E E+P++ D ++ S
Sbjct: 2825 SSETNSTTSRV---MEEKDEYSSSETTGEKPEQNDDDTI-------------------KS 2862
Query: 699 DEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST 758
EE P + + G+ ++ + L + G + EQ+ S ++ + + T
Sbjct: 2863 QEEDQPIII------KRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQT 2916
Query: 759 WESFKRLVTPRKKSKSK--LEEKSEDSIAGSGVEHS-----TPDTEPGKEESWVSIKKFI 811
ES K +++S S EEK S+ G + + D E + E
Sbjct: 2917 DESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSD 2976
Query: 812 PGRRKKRPDGKQEQAPVEDAGPTGA 836
P KK + +E+ E+ P+GA
Sbjct: 2977 PVEDKKEQESDEEEEEEEEDEPSGA 3001
Score = 41.2 bits (95), Expect = 0.009
Identities = 87/421 (20%), Positives = 152/421 (36%), Gaps = 64/421 (15%)
Query: 109 QRDSEDVSKRDSDKE----MATKSAVVHDITDDGQEETP-------------EIIEQIPS 151
++ +D S R S E M T S+ ++ D G EE+P ++ +PS
Sbjct: 2620 EKTGDDNSTRKSFPEEGDIMVTVSSE-ENVCDIGNEESPLNVLGGLKLKANLKMEAYVPS 2678
Query: 152 SESNLEELTQPTESQAND--IGFKKVFK---FVGFKFTVKKDKTEKPDTVQLLTVKKDEG 206
E E+ P ES G ++ + V V+ + + + K G
Sbjct: 2679 EEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNK--G 2736
Query: 207 EGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQ------ 260
E ++G D+ + G S E++PK+ E+ KR++ +S E
Sbjct: 2737 EISSGRKDNAEAISGH----SVEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLD 2792
Query: 261 -----AVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +C E ++E S+ E +SET ST + + +T+ K
Sbjct: 2793 SRIETAQRQCPETEPHDTKEENSRDLEE-LPKTSSETNSTTSRVMEEKDEYSSSETTGEK 2851
Query: 316 PK---EDEVEASE-------KKKEQEPEKVDTE------EDGKAE---VASEKLTASEQA 356
P+ +D +++ E K+K P K E +D K + V E+ +S +
Sbjct: 2852 PEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKL 2911
Query: 357 HPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD----EKIEVHQ 412
+ ES E E EE++ S KP T D E Q
Sbjct: 2912 KVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ 2971
Query: 413 EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVS 472
+ V V +E EE++ E E+ +A+ + + + + + +E
Sbjct: 2972 KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPP 3031
Query: 473 G 473
G
Sbjct: 3032 G 3032
Score = 40.4 bits (93), Expect = 0.016
Identities = 75/374 (20%), Positives = 146/374 (39%), Gaps = 49/374 (13%)
Query: 324 SEKKKEQE----PEKV-DTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVE 378
SE++K E PE + + G AE+ E L +E + + +E S Y K E
Sbjct: 2678 SEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRTNEEIHSESYNKGE 2737
Query: 379 LPS-----EEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKT 433
+ S E +SG ++ K E+ E H + + H + E+ ++
Sbjct: 2738 ISSGRKDNAEAISGHSVEADPKEV--------EEEERHMPKRKRKQHYLSSEDEPDDNP- 2788
Query: 434 EVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGA-----DLSPDEKV 488
+V ++ + E + + E +++L +L +T T + S E
Sbjct: 2789 DVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETT 2848
Query: 489 LSKPPEGVVSEVEMLSSQER------MKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDE 542
KP + ++ + + SQE + +G P K +T K K G
Sbjct: 2849 GEKPEQ---NDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQS 2905
Query: 543 ESGEHTQV-PADSPDSQEEQKGESSASSPEEPEEI--TCLEKGLAEVQQDGEAEEGATSD 599
S +V D + + E S S+ + E+I + +G + +++ +S+
Sbjct: 2906 PSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSE 2965
Query: 600 GEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVK----SATLSSTESTASEMQE 655
E+KR+ K V+ ++ ESD+E+E ++ + T S+T S A +
Sbjct: 2966 PERKRQ---------KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKT 3016
Query: 656 EMKGSVEEPKPEEP 669
++ S++ + P
Sbjct: 3017 QLSPSIKRKREVSP 3030
Score = 36.2 bits (82), Expect = 0.29
Identities = 50/205 (24%), Positives = 87/205 (42%), Gaps = 27/205 (13%)
Query: 1570 EMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSD 1629
E +TS L +A +A ++ + +T + + S P T + E T
Sbjct: 206 ETITS-LNQEASAARASTETSNAKTSERASKKLPSQ----PTTDTSTDKERT-------- 252
Query: 1630 ISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIE 1689
S+DM++ + T EG + E LP E TK E + LL + ++
Sbjct: 253 -SEDMADKEKSTADSGGEGLETAPKSEEFSDLPCPVEEIKNYTK---EHNNLILLNKDVQ 308
Query: 1690 KSLVEPKE------DEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQE 1743
+ E K ++K D + E + T+ +K+S DT K K+++ A+E
Sbjct: 309 QESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQ--KVKDEKQAKE 366
Query: 1744 VELQEGKVHSE--SDKAITPQAQEE 1766
E++ K+ SE S+KA T + +E
Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKE 391
>gi|148806928 hypothetical protein LOC57482 [Homo sapiens]
Length = 1233
Score = 78.6 bits (192), Expect = 5e-14
Identities = 256/1360 (18%), Positives = 482/1360 (35%), Gaps = 250/1360 (18%)
Query: 47 AASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTE 106
A S+ + + ++ L + + +Q +++ G + +N + + EE++ +T
Sbjct: 18 AESEQTVQAMSQDNILGKVKTLQQQLGKNIKFGQRSPNAIPMNKANSGEASLEEDLFLT- 76
Query: 107 VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIE--QIPSSESNLEELTQPTE 164
S E+ T+ +V ++ +TP + +P + S +EE P +
Sbjct: 77 -------------SPMEIVTQQDIVLSDAENKSSDTPSSLSPLNLPGAGSEMEEKVAPVK 123
Query: 165 SQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGE 224
K+ F G +V D + L + D A HK
Sbjct: 124 PSRP----KRHFSSAGTIESVNLD------AIPLAIARLDNS-----AAKHK-------- 160
Query: 225 AASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESP 284
A K KQ K L ++ H + G C ++ E +P+ E P
Sbjct: 161 LAVKPK--KQRVSKKHRRLAQDPQHEQ------GGLESRPCLDQNGHPGEDKPTWHEEEP 212
Query: 285 TSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKK--------------EQ 330
+P+ SE ++ + WR+ + K K + EA+EK++ E+
Sbjct: 213 -NPLDSEEERRRQEDY------WRELEA--KCKRQKAEAAEKRRLEEQRLQALERRLWEE 263
Query: 331 EPEKVDTEEDGKAE---VASEKLTASEQAHPQE-PAESAHEPRLSAEYEKVELPSEEQVS 386
+ EE+G+ + + +E+ EQ E P E R E E++E E +
Sbjct: 264 NRRQELLEEEGEGQEPPLEAERAPREEQQRSLEAPGWEDAERREREERERLEAEEERRRL 323
Query: 387 GSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEE 446
+Q +EE+ +E+ +EE + EE E E+E ++
Sbjct: 324 QAQAQAEERRRLEEDARLEERRRQEEEEGRCAEELKRQEEEEAEGWEELE--------QQ 375
Query: 447 LVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEV-----E 501
E+ P+ E E + E GE+ +G D + G +SE+ E
Sbjct: 376 EAEVQGPPEALEETGEGRRGAEEEDLGEEEEEGQAHLEDWR-------GQLSELLNDFEE 428
Query: 502 MLSSQERMKVQG----SPLKKLFTSTGLKKLSGKKQKGKRG---GGDEESGEHTQVPADS 554
L QER+K +G S + + ++Q+G+ G G D E + D+
Sbjct: 429 RLEDQERLKPEGQREHSEEPGICEEQNPEAERRREQQGRSGDFQGADRPGPEEKREEGDT 488
Query: 555 PDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFK 614
+++ +A P E +E LE+G +K E + +
Sbjct: 489 EPLLKQEGPVEAAQPPVERKEAAALEQG-------------------RKVEELRWQEVDE 529
Query: 615 KMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPK-----PEEP 669
+ P+ + S K+ KV + ++ + T + + +EPK P +
Sbjct: 530 RQTMPRPYTFQVSSGGKQILFPKVNLSPVTPAKDTG------LTAAPQEPKAPKASPVQH 583
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKAD---EAGKDKETGTD 726
SV A++ G+ S ++ K++ G +K AG++ G
Sbjct: 584 ALPSSLSVPHTAILVTGAQLCGPAVNLSQIKDTACKSLLGLEEKKHAEAPAGENPPRGPG 643
Query: 727 GILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAG 786
AGS G + P Q SP+ ++ W S + + +S + E+ +
Sbjct: 644 DARAGS-------GKAKPRQE-SPSSASALAEWASIRSRILKNAESDPRSSERDQ----- 690
Query: 787 SGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAG----PTGANEDDSD 842
PG E + GR R G Q + P +A P D
Sbjct: 691 ---------LRPGDEST-------PRGRCDSR--GNQRKTPPVNAKFSIMPAWQKFSDGG 732
Query: 843 VPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRA 902
+E +++ + M ++++A QP E+ K +S++H A +G +
Sbjct: 733 TETSKQSTEAESIRKRPM-LGPSEETAPQPPPAGVRELGKGPEKSEMHREPADTTEGCKF 791
Query: 903 ATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARG 962
A + PS++ S+ P ++V+A E T ++ N A+
Sbjct: 792 AKDL----PSFLVPSLPYP----------------PQKVVAHTEFTTSSDSETANGIAKP 831
Query: 963 DTVV--SEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDS-PDTTEEA 1019
D V+ E + +P + T L + A ++ + S+ D+ P A
Sbjct: 832 DPVMPGGEEKASPFGIKLRRTNYSL--RFNCDQQAEQKKKKRHSSTGDSADAGPPAAGSA 889
Query: 1020 TPVQEVEGGV----PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE 1075
+E+EG P + ++ ++ + AE S GP P ++
Sbjct: 890 RGEKEMEGVALKHGPSLPQERKQAPSTRRDSAEPSSSRSVPVAHPGP-----PPASSQTP 944
Query: 1076 RPEEQAEAS--GLKKETDVVLKVDAQEAKTEPFTQ----------GKVVGQTTPESFEKA 1123
PE A+ L ++ + K +Q P ++ + G+ PE E +
Sbjct: 945 APEHDKAANKMPLAQKPALAPKPTSQTPPASPLSKLSRPYLVELLSRRAGRPDPEPSEPS 1004
Query: 1124 PQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAP 1183
+ ES + E + +E + P T E TP A
Sbjct: 1005 KEDQESSDRRPPSPPGPEERKGQKRDEEEEATERKPASPPLPATQQEKPSQTPEA----- 1059
Query: 1184 GTTQKDEIVEIH--EENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMED 1241
G +K + H + +++ ++ + QK++ F Q+ T+E+ K
Sbjct: 1060 GRKEKPMLQSRHSLDGSKLTEKVETAQPLWITLALQKQK-----GFREQQATREERKQAR 1114
Query: 1242 TLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTE 1301
+ +K +S E VS+ S G+ + GS+ + EK E
Sbjct: 1115 EAKQAEK-LSKENVSV-SVQPGSSSVSR---------------AGSLHKSTALPEEKRPE 1157
Query: 1302 VALKGEGTEEAECKKDDAL----ELQSHAKSPPSPVEREM 1337
A+ E + KK + L ++ +PP+P+ +E+
Sbjct: 1158 TAVSRLERRE-QLKKANTLPTSVTVEISDSAPPAPLVKEV 1196
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 77.4 bits (189), Expect = 1e-13
Identities = 110/482 (22%), Positives = 192/482 (39%), Gaps = 53/482 (10%)
Query: 615 KMVTPKKRVRRP------SESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEE 668
K+ PK +V+ E+ EDE +++ A + TE A M+EE K + EE K EE
Sbjct: 440 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEE 498
Query: 669 PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKA----MGGDHQKADEAGKDKETG 724
P+ + + + ++ + + + + G +EEG + G +A+E G +KE G
Sbjct: 499 PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE-G 557
Query: 725 TDGILAGSQEHDPGQGSSSPEQAGSPTE------GEGVSTWESF---KRLVTPRKKS--- 772
+ G QE + + E+A + E E V+T E ++ P K
Sbjct: 558 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 617
Query: 773 -KSKLEEKSEDSIAGSGVEH---STPDTEPGKEESWVSIKKFIPGRRKKRPDGKQ----- 823
KS +EEK + + S VE S P +E+ + K + K P K
Sbjct: 618 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 677
Query: 824 -----EQAPVEDA------GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQP 872
++PVE+A G E++ P E + EK + +K AE P
Sbjct: 678 AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 737
Query: 873 -EQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAAL 931
+++A EV +VH+ +G E+ S E ++ A+ +
Sbjct: 738 VKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK-GAKGSR 796
Query: 932 LTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGT 991
+ + EV +EE T+ RE V + +L+P A E G ++
Sbjct: 797 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSP----ADEKK---GGDKSE 849
Query: 992 EASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVK 1051
E +T E +++ + T+ T Q+VE EE+ T++V + + +
Sbjct: 850 EKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIV 909
Query: 1052 EE 1053
+E
Sbjct: 910 KE 911
Score = 68.6 bits (166), Expect = 5e-11
Identities = 109/442 (24%), Positives = 175/442 (39%), Gaps = 48/442 (10%)
Query: 359 QEPAESAHEPRLSAEYEKVE-LPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVA 417
Q+P A P+L +++ VE + E +V + EE A E++ V +E
Sbjct: 437 QKPKVEA--PKLKVQHKFVEEIIEETKVEDEKSEMEE-----ALTAITEELAVSMKEEKK 489
Query: 418 EVHVSTVEERTEEQKTEVEETAGS-----VPAEELVEMDAEPQEAEPAKELVKLKETCVS 472
E EE+ EE + E EE A A E+ E + E +E E +E + E S
Sbjct: 490 EA----AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 545
Query: 473 GEDPTQGADL-SPDEKVLSKPPEG---VVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKL 528
+ G++ EK + EG +E E ++E KV+ +++ T L
Sbjct: 546 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE-EKSEEVATKEELVAD 604
Query: 529 SGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQ 588
+ ++ K +S + + P S E+KG+S P+ P E EKG + V +
Sbjct: 605 AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV--PKSPVE----EKGKSPVPK 658
Query: 589 DGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTES 648
E+G K +P K PK V E+ + E+ K + E
Sbjct: 659 SPVEEKG------KSPVSKSPVEEKAKSPVPKSPV---EEAKSKAEVGKGEQKEEEEKEV 709
Query: 649 TASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKK--RARRGSSSDEEGGPKA 706
+ +E+++ E+PK K+K ++ V EA+ V + K + + EEG P
Sbjct: 710 KEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ 769
Query: 707 MGGDHQKADEAGKDKETGTDGILAGSQEHDPG-----QGSSSPEQ----AGSPTEGEGVS 757
+ +KA G +E G+D GS++ D +G EQ GS E E
Sbjct: 770 QEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGV 829
Query: 758 TWESFKRLVTPRKKSKSKLEEK 779
KK K EEK
Sbjct: 830 VTNGLDLSPADEKKGGDKSEEK 851
Score = 61.2 bits (147), Expect = 8e-09
Identities = 121/523 (23%), Positives = 212/523 (40%), Gaps = 87/523 (16%)
Query: 483 SPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPL-KKLFTSTGLKKLSGKKQKGKRGGGD 541
+P KV K E ++ E ++ + M+ + + ++L S +K ++K + +
Sbjct: 443 APKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAE 502
Query: 542 EE--SGEHTQVPADSPDSQEEQKGESSASSPEEPEE------ITCLEKGLAEVQQDGEAE 593
EE + + + V A +P+ +EE+ + EE EE E+G +E + E E
Sbjct: 503 EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKE 562
Query: 594 EGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSE--SDKEDELDKVKSATLSSTESTAS 651
EG +GE + E A K+ +K+V SE + KE+ + K +S
Sbjct: 563 EGEQEEGETEAEAEGEEAEAKE----EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 618
Query: 652 EMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDH 711
+ E KG + P P+ P + K ++ S EE G +
Sbjct: 619 KSPVEEKG--KSPVPKSPVEE----------------KGKSPVPKSPVEEKGKSPV--PK 658
Query: 712 QKADEAGKDKETGTDGILAGSQEHDPGQGSSSP-EQAGSPTE-GEGVSTWESFKRL-VTP 768
+E GK + + +E SP E+A S E G+G E K + P
Sbjct: 659 SPVEEKGKSPVSKSP-----VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP 713
Query: 769 RKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEES---WVSIKKFIPGRRKK--RPDGK- 822
+++ K EEK +D V P KEE+ V+I K + +K + +GK
Sbjct: 714 KEEKVEKKEEKPKD------VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 767
Query: 823 --QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVE-----REKMEAQQAQKSAEQPEQK 875
QE+ + G G+ E+ SD A E AV +E++E + +K + + E+K
Sbjct: 768 LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 827
Query: 876 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEE 935
+LS AD + EE+ VT+ +E++ +E +
Sbjct: 828 GVVTNGLDLSP----------ADEKKGGDKSEEK------VVVTKTVEKITSEGGDGATK 871
Query: 936 VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTA 978
+ + V TVT+ + E+ E + +VS ++ E VT+
Sbjct: 872 YITKSV-------TVTQKVEEHEETFEEKLVSTKKV--EKVTS 905
Score = 60.8 bits (146), Expect = 1e-08
Identities = 115/480 (23%), Positives = 183/480 (38%), Gaps = 61/480 (12%)
Query: 31 GPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNG 90
GP P T I P + + Q + + E+ ++ ++ ++ A+
Sbjct: 421 GPLYTHRPPITISSKI--QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITE 478
Query: 91 QGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIP 150
+ A++ +EE++ E E+ + + ++ A KS V + PE+ E+
Sbjct: 479 ELAVSMKEEKKEAAEE-----KEEEPEAEEEEVAAKKSPV--------KATAPEVKEE-- 523
Query: 151 SSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAA 210
E EE E + D G K G + E+ + + T + EGE A
Sbjct: 524 --EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 581
Query: 211 GAGDHKDPSLGAGEAASKESEPKQSTEKPEETL---------KREQSHAEISPPAESGQA 261
+ K A +E EKPE+ ++ +S SP E G++
Sbjct: 582 AKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 641
Query: 262 ------VEEC------KEEGEEKQEKEPSKSA--ESPTSPVTSETGSTFKKFFTQGWAGW 307
VEE K EEK + SKS E SPV K G G
Sbjct: 642 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG-KGE 700
Query: 308 RKKTSFRK----PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASE--KLTASEQAHPQEP 361
+K+ ++ PKE++VE E+K + PEK E K E +E +T S + H ++
Sbjct: 701 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKE 760
Query: 362 AESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQE-EVVAEVH 420
+ +P L E EK E+ G G EE A E I V+ E E EV
Sbjct: 761 TKEEGKP-LQQEKEK------EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 813
Query: 421 VSTVEERT--EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 478
T E+ + EE+K V PA+E D ++ K + K+ T G+ T+
Sbjct: 814 QETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKI--TSEGGDGATK 871
Score = 58.9 bits (141), Expect = 4e-08
Identities = 104/430 (24%), Positives = 157/430 (36%), Gaps = 48/430 (11%)
Query: 899 GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENR 958
G+ + R P IS+ + +P +VEA + + +E E+I E + V + E
Sbjct: 417 GSITGPLYTHRPPITISSKIQKP--KVEAPKLKVQHKFVE-EIIEETK---VEDEKSEME 470
Query: 959 EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEE 1018
EA +T E + + AEE E AEE +P+ EE
Sbjct: 471 EAL-------TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 523
Query: 1019 ATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPE 1078
+E EG EE+E + AE+ E + G+ E+ Q EAE
Sbjct: 524 EGEKEEEEGQ----EEEEEEDEGAKSDQAEEGGSEKE--GSSEKEEGEQEEGETEAEAEG 577
Query: 1079 EQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTT 1138
E+AEA KK +E E T+ ++V E EKA E +
Sbjct: 578 EEAEAKEEKK---------VEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 628
Query: 1139 CQAETLAGVKSQEMVMEQAIPPDSVETPTDS--ETDGSTPVA----DFDAPGTTQKDEIV 1192
++ K + V + + S E G +PV+ + A K +
Sbjct: 629 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 688
Query: 1193 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252
E + EV G Q E E A KE +E+ K+ + + +E
Sbjct: 689 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK----EEKPKDVPEKKKAESPVKEEAVA 744
Query: 1253 ETVSILS------KTEGTQEADQYADEKTKDVPFFEG---LEGSIDTGITVSREKVTEVA 1303
E V+I + E +E EK K+ EG EGS D G SR++ V
Sbjct: 745 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS-DKGAKGSRKEDIAVN 803
Query: 1304 LKGEGTEEAE 1313
+ EG EE E
Sbjct: 804 GEVEGKEEVE 813
Score = 55.1 bits (131), Expect = 6e-07
Identities = 148/783 (18%), Positives = 282/783 (36%), Gaps = 85/783 (10%)
Query: 1031 DIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGLK 1087
D +QE R + K + QL ED+ + +R E E R + +A L+
Sbjct: 148 DAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALR 207
Query: 1088 KETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTE------SIESSELVTTCQA 1141
K+ + V + K Q +V + E A + + ++E + + T +
Sbjct: 208 KDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDIS 267
Query: 1142 ETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEE-NEV 1200
L ++SQ + S + +E A K+ I EE E
Sbjct: 268 TALKEIRSQ-------LESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEY 320
Query: 1201 ASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
QS E E+V KE S + + + S +DT++ + E+ +K
Sbjct: 321 RRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRG------TK 374
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E + +Y D ++ ++D I R+ L+GE T +
Sbjct: 375 WEMARHLREYQD--------LLNVKMALDIEIAAYRK-----LLEGEETRFSTFAGSITG 421
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--------------EPTHVNEEKLEHETAVT- 1365
L +H PP + + +++ K EA E T V +EK E E A+T
Sbjct: 422 PLYTHR--PPITISSK----IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTA 475
Query: 1366 VSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAA 1425
++EE++ + + K+ ++ E P +EE K V+++
Sbjct: 476 ITEELAVSMKEE---------KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGE 526
Query: 1426 EEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTP 1485
+EE+ E + G + A +E SSEK E +A G + +AK
Sbjct: 527 KEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEK 586
Query: 1486 VIVSAT----TKKGLSSDLEGEKTTSLKWK--SDEVDEQVACQEVKVSVAIEDLEPENGI 1539
+ + TK+ L +D + EK K V+E+ K V + P
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 646
Query: 1540 LELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGE 1599
E S + ++ ++ V + + ++ K+ ++ E ++E E
Sbjct: 647 PVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE 706
Query: 1600 EPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEV 1659
+ A E + +E+ + + K+ + A T+T V+ + + E
Sbjct: 707 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGK 766
Query: 1660 VLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDA 1719
L E+E AG + E++G A+ K + + +G + + E + +
Sbjct: 767 PLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826
Query: 1720 SGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSEL 1779
G +T D + +K+ D E +K + + E++ + + A +
Sbjct: 827 KGVVT-NGLDLSPADEKKGGDKSE------------EKVVVTKTVEKITSEGGDGATKYI 873
Query: 1780 TES 1782
T+S
Sbjct: 874 TKS 876
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
sapiens]
Length = 540
Score = 77.4 bits (189), Expect = 1e-13
Identities = 110/482 (22%), Positives = 192/482 (39%), Gaps = 53/482 (10%)
Query: 615 KMVTPKKRVRRP------SESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEE 668
K+ PK +V+ E+ EDE +++ A + TE A M+EE K + EE K EE
Sbjct: 64 KVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE-KEEE 122
Query: 669 PKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKA----MGGDHQKADEAGKDKETG 724
P+ + + + ++ + + + + G +EEG + G +A+E G +KE G
Sbjct: 123 PEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE-G 181
Query: 725 TDGILAGSQEHDPGQGSSSPEQAGSPTE------GEGVSTWESF---KRLVTPRKKS--- 772
+ G QE + + E+A + E E V+T E ++ P K
Sbjct: 182 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPV 241
Query: 773 -KSKLEEKSEDSIAGSGVEH---STPDTEPGKEESWVSIKKFIPGRRKKRPDGKQ----- 823
KS +EEK + + S VE S P +E+ + K + K P K
Sbjct: 242 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEK 301
Query: 824 -----EQAPVEDA------GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQP 872
++PVE+A G E++ P E + EK + +K AE P
Sbjct: 302 AKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESP 361
Query: 873 -EQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAAL 931
+++A EV +VH+ +G E+ S E ++ A+ +
Sbjct: 362 VKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDK-GAKGSR 420
Query: 932 LTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGT 991
+ + EV +EE T+ RE V + +L+P A E G ++
Sbjct: 421 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSP----ADEKK---GGDKSE 473
Query: 992 EASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVK 1051
E +T E +++ + T+ T Q+VE EE+ T++V + + +
Sbjct: 474 EKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIV 533
Query: 1052 EE 1053
+E
Sbjct: 534 KE 535
Score = 68.6 bits (166), Expect = 5e-11
Identities = 109/442 (24%), Positives = 175/442 (39%), Gaps = 48/442 (10%)
Query: 359 QEPAESAHEPRLSAEYEKVE-LPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVA 417
Q+P A P+L +++ VE + E +V + EE A E++ V +E
Sbjct: 61 QKPKVEA--PKLKVQHKFVEEIIEETKVEDEKSEMEE-----ALTAITEELAVSMKEEKK 113
Query: 418 EVHVSTVEERTEEQKTEVEETAGS-----VPAEELVEMDAEPQEAEPAKELVKLKETCVS 472
E EE+ EE + E EE A A E+ E + E +E E +E + E S
Sbjct: 114 EA----AEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKS 169
Query: 473 GEDPTQGADL-SPDEKVLSKPPEG---VVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKL 528
+ G++ EK + EG +E E ++E KV+ +++ T L
Sbjct: 170 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVE-EKSEEVATKEELVAD 228
Query: 529 SGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQ 588
+ ++ K +S + + P S E+KG+S P+ P E EKG + V +
Sbjct: 229 AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV--PKSPVE----EKGKSPVPK 282
Query: 589 DGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTES 648
E+G K +P K PK V E+ + E+ K + E
Sbjct: 283 SPVEEKG------KSPVSKSPVEEKAKSPVPKSPV---EEAKSKAEVGKGEQKEEEEKEV 333
Query: 649 TASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKK--RARRGSSSDEEGGPKA 706
+ +E+++ E+PK K+K ++ V EA+ V + K + + EEG P
Sbjct: 334 KEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ 393
Query: 707 MGGDHQKADEAGKDKETGTDGILAGSQEHDPG-----QGSSSPEQ----AGSPTEGEGVS 757
+ +KA G +E G+D GS++ D +G EQ GS E E
Sbjct: 394 QEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGV 453
Query: 758 TWESFKRLVTPRKKSKSKLEEK 779
KK K EEK
Sbjct: 454 VTNGLDLSPADEKKGGDKSEEK 475
Score = 61.2 bits (147), Expect = 8e-09
Identities = 121/523 (23%), Positives = 212/523 (40%), Gaps = 87/523 (16%)
Query: 483 SPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPL-KKLFTSTGLKKLSGKKQKGKRGGGD 541
+P KV K E ++ E ++ + M+ + + ++L S +K ++K + +
Sbjct: 67 APKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAE 126
Query: 542 EE--SGEHTQVPADSPDSQEEQKGESSASSPEEPEE------ITCLEKGLAEVQQDGEAE 593
EE + + + V A +P+ +EE+ + EE EE E+G +E + E E
Sbjct: 127 EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKE 186
Query: 594 EGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSE--SDKEDELDKVKSATLSSTESTAS 651
EG +GE + E A K+ +K+V SE + KE+ + K +S
Sbjct: 187 EGEQEEGETEAEAEGEEAEAKE----EKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242
Query: 652 EMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDH 711
+ E KG + P P+ P + K ++ S EE G +
Sbjct: 243 KSPVEEKG--KSPVPKSPVEE----------------KGKSPVPKSPVEEKGKSPV--PK 282
Query: 712 QKADEAGKDKETGTDGILAGSQEHDPGQGSSSP-EQAGSPTE-GEGVSTWESFKRL-VTP 768
+E GK + + +E SP E+A S E G+G E K + P
Sbjct: 283 SPVEEKGKSPVSKSP-----VEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP 337
Query: 769 RKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEES---WVSIKKFIPGRRKK--RPDGK- 822
+++ K EEK +D V P KEE+ V+I K + +K + +GK
Sbjct: 338 KEEKVEKKEEKPKD------VPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKP 391
Query: 823 --QEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVE-----REKMEAQQAQKSAEQPEQK 875
QE+ + G G+ E+ SD A E AV +E++E + +K + + E+K
Sbjct: 392 LQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
Query: 876 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEE 935
+LS AD + EE+ VT+ +E++ +E +
Sbjct: 452 GVVTNGLDLSP----------ADEKKGGDKSEEK------VVVTKTVEKITSEGGDGATK 495
Query: 936 VLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTA 978
+ + V TVT+ + E+ E + +VS ++ E VT+
Sbjct: 496 YITKSV-------TVTQKVEEHEETFEEKLVSTKKV--EKVTS 529
Score = 60.8 bits (146), Expect = 1e-08
Identities = 115/480 (23%), Positives = 183/480 (38%), Gaps = 61/480 (12%)
Query: 31 GPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNG 90
GP P T I P + + Q + + E+ ++ ++ ++ A+
Sbjct: 45 GPLYTHRPPITISSKI--QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITE 102
Query: 91 QGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIP 150
+ A++ +EE++ E E+ + + ++ A KS V + PE+ E+
Sbjct: 103 ELAVSMKEEKKEAAEE-----KEEEPEAEEEEVAAKKSPV--------KATAPEVKEE-- 147
Query: 151 SSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAA 210
E EE E + D G K G + E+ + + T + EGE A
Sbjct: 148 --EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAE 205
Query: 211 GAGDHKDPSLGAGEAASKESEPKQSTEKPEETL---------KREQSHAEISPPAESGQA 261
+ K A +E EKPE+ ++ +S SP E G++
Sbjct: 206 AKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKS 265
Query: 262 ------VEEC------KEEGEEKQEKEPSKSA--ESPTSPVTSETGSTFKKFFTQGWAGW 307
VEE K EEK + SKS E SPV K G G
Sbjct: 266 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVG-KGE 324
Query: 308 RKKTSFRK----PKEDEVEASEKKKEQEPEKVDTEEDGKAEVASE--KLTASEQAHPQEP 361
+K+ ++ PKE++VE E+K + PEK E K E +E +T S + H ++
Sbjct: 325 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKE 384
Query: 362 AESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQE-EVVAEVH 420
+ +P L E EK E+ G G EE A E I V+ E E EV
Sbjct: 385 TKEEGKP-LQQEKEK------EKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 437
Query: 421 VSTVEERT--EEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQ 478
T E+ + EE+K V PA+E D ++ K + K+ T G+ T+
Sbjct: 438 QETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKI--TSEGGDGATK 495
Score = 58.9 bits (141), Expect = 4e-08
Identities = 104/430 (24%), Positives = 157/430 (36%), Gaps = 48/430 (11%)
Query: 899 GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENR 958
G+ + R P IS+ + +P +VEA + + +E E+I E + V + E
Sbjct: 41 GSITGPLYTHRPPITISSKIQKP--KVEAPKLKVQHKFVE-EIIEETK---VEDEKSEME 94
Query: 959 EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEE 1018
EA +T E + + AEE E AEE +P+ EE
Sbjct: 95 EAL-------TAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEE 147
Query: 1019 ATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPE 1078
+E EG EE+E + AE+ E + G+ E+ Q EAE
Sbjct: 148 EGEKEEEEGQ----EEEEEEDEGAKSDQAEEGGSEKE--GSSEKEEGEQEEGETEAEAEG 201
Query: 1079 EQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTT 1138
E+AEA KK +E E T+ ++V E EKA E +
Sbjct: 202 EEAEAKEEKK---------VEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKS 252
Query: 1139 CQAETLAGVKSQEMVMEQAIPPDSVETPTDS--ETDGSTPVA----DFDAPGTTQKDEIV 1192
++ K + V + + S E G +PV+ + A K +
Sbjct: 253 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 312
Query: 1193 EIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252
E + EV G Q E E A KE +E+ K+ + + +E
Sbjct: 313 EAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK----EEKPKDVPEKKKAESPVKEEAVA 368
Query: 1253 ETVSILS------KTEGTQEADQYADEKTKDVPFFEG---LEGSIDTGITVSREKVTEVA 1303
E V+I + E +E EK K+ EG EGS D G SR++ V
Sbjct: 369 EVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGS-DKGAKGSRKEDIAVN 427
Query: 1304 LKGEGTEEAE 1313
+ EG EE E
Sbjct: 428 GEVEGKEEVE 437
Score = 56.2 bits (134), Expect = 3e-07
Identities = 117/507 (23%), Positives = 193/507 (38%), Gaps = 89/507 (17%)
Query: 1215 PAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEK 1274
P RPP S Q+ E K++ ++H E +E + DEK
Sbjct: 46 PLYTHRPPITISSKIQKPKVEAPKLK--VQHKFVEEIIEETKV-------------EDEK 90
Query: 1275 TKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVE 1334
++ ++ +T E++ V++K E E AE K+++ + + SPV+
Sbjct: 91 SE-----------MEEALTAITEELA-VSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK 138
Query: 1335 REMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEG 1394
E E + E EE+ E E A + E +G E EG
Sbjct: 139 ATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAE--------------EGGSE---KEG 181
Query: 1395 SPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETL---------- 1444
S G++E T+ + + EA A+EEK + E + + T E L
Sbjct: 182 SSEKEEGEQEEGETEAEAEGEEAE------AKEEKKVEEKSEEVATKEELVADAKVEKPE 235
Query: 1445 ---EPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKG---LSS 1498
P V E+ S + G+ VP P + +PV S +KG +S
Sbjct: 236 KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSK 295
Query: 1499 DLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQ---NIIQ 1555
EK S KS V+E + EV E+ E E E K K + ++ +
Sbjct: 296 SPVEEKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPE 354
Query: 1556 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1615
+ EE E++T + H+ K ++++ G+ ++E E+ +A + S +
Sbjct: 355 KKKAESPVKEEAVAEVVTITKSVKVHLEK-ETKEEGKPLQQEKEKEKAGGEG----GSEE 409
Query: 1616 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGA--GTK 1673
E S+ A G DI+ + EVEG +Q+ +E EEE G G
Sbjct: 410 EGSDKGAKGSRKEDIA----------VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLD 459
Query: 1674 SVPEDDGHALLAERIEKSLVEPKEDEK 1700
P D+ ++ E+ +V K EK
Sbjct: 460 LSPADEKKG--GDKSEEKVVVTKTVEK 484
Score = 43.9 bits (102), Expect = 0.001
Identities = 86/463 (18%), Positives = 174/463 (37%), Gaps = 35/463 (7%)
Query: 1327 KSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVT-VSEEVSKQLLQTVNVPIIDG 1385
++P V+ + V ++ E T V +EK E E A+T ++EE++ + +
Sbjct: 66 EAPKLKVQHKFVEEI------IEETKVEDEKSEMEEALTAITEELAVSMKEE-------- 111
Query: 1386 AKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLE 1445
K+ ++ E P +EE K V+++ +EE+ E + G +
Sbjct: 112 -KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSD 170
Query: 1446 PAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSAT----TKKGLSSDLE 1501
A +E SSEK E +A G + +AK + + TK+ L +D +
Sbjct: 171 QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 230
Query: 1502 GEKTTSLKWK--SDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVD 1559
EK K V+E+ K V + P E S + ++ ++
Sbjct: 231 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 290
Query: 1560 QFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESE 1619
V + + ++ K+ ++ E ++E E+ A E + +E+ +
Sbjct: 291 SPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPK 350
Query: 1620 STAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDD 1679
+ K+ + A T+T V+ + + E L E+E AG + E++
Sbjct: 351 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 410
Query: 1680 GHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKE 1739
G A+ K + + +G + + E + + G +T D + +K+
Sbjct: 411 GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVT-NGLDLSPADEKKGG 469
Query: 1740 DAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES 1782
D E +K + + E++ + + A +T+S
Sbjct: 470 DKSE------------EKVVVTKTVEKITSEGGDGATKYITKS 500
Score = 40.8 bits (94), Expect = 0.012
Identities = 62/305 (20%), Positives = 116/305 (38%), Gaps = 42/305 (13%)
Query: 1505 TTSLKWKSDEVDE-QVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVR 1563
T S K + +V+ ++ Q V IE+ + E+ E+E + + + + + ++
Sbjct: 55 TISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKE 114
Query: 1564 TEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDE--------------- 1608
E E +E + A A + E+EGE+ + Q+E
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 1609 ---------TPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEE- 1658
+EE E+ A + +K+ + EK+ V + V D ++E+
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 1659 -------VVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQN 1711
P EE+G KS E+ G + + KS VE EKG P++
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKS----PVPKSPVE----EKGKS-PVPKSPV 285
Query: 1712 SALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQE 1771
+ S +E + PK +E + E+ +G+ E +K + +EE +++
Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK 345
Query: 1772 RESAK 1776
E K
Sbjct: 346 EEKPK 350
Score = 32.0 bits (71), Expect = 5.5
Identities = 36/143 (25%), Positives = 63/143 (44%), Gaps = 21/143 (14%)
Query: 1644 VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDD 1703
VE V + +EE++ EE KS E+ A+ E + S+ E K++ +
Sbjct: 65 VEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTAI-TEELAVSMKEEKKEAAEEK 119
Query: 1704 VDDPENQNSALADTDASGGLTKESP-DTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQ 1762
++PE + +A K+SP P+ KE+E +E E + + E + A + Q
Sbjct: 120 EEEPEAEEEEVA--------AKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 171
Query: 1763 AQE-------ELQKQERESAKSE 1778
A+E +K+E E + E
Sbjct: 172 AEEGGSEKEGSSEKEEGEQEEGE 194
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 75.1 bits (183), Expect = 6e-13
Identities = 245/1198 (20%), Positives = 424/1198 (35%), Gaps = 244/1198 (20%)
Query: 16 PEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQ-KNGQLSTINGVAEQDEL 74
P +STP P P AP D I A D LLQ + G+ + + +
Sbjct: 383 PTLASTPIPPTPQ--------APSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARV 434
Query: 75 SLQEGDLNG--QKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDS------------ 120
++ L G + G + + E+ + D + +D
Sbjct: 435 AIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICR 494
Query: 121 -----------DKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQAND 169
+KE A + VV + + EE ++I S+ LE+ T + +
Sbjct: 495 GEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQ 554
Query: 170 IGFKKVFKFVGFKFTVKKDKTEKPDTVQ--LLTVKKDEGEGAAGAGD------HKDPSLG 221
K + T++++ E P +++ L T+K E E D + ++G
Sbjct: 555 ESLKTLEN--QSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVG 612
Query: 222 AGEAASKE-SEPKQSTEKP-EETLKREQSHAE--ISPPAESGQAVEECKEEGE-----EK 272
+ KE ++ QS +K +E +K + + E + P E+ + V +E E EK
Sbjct: 613 QLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEK 672
Query: 273 QEKEPSKSA----ESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKK 328
+ +EP +S E P+T E + + K +FR S +K+
Sbjct: 673 ENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDE------NKEAFR---------SLEKE 717
Query: 329 EQEPEKVDTEEDGK----AEVASEKLTASEQAHPQE-----PAESAHEPRLSAEYEKVEL 379
QEP K EED E + K S + QE E+ R E +++ L
Sbjct: 718 NQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTL 777
Query: 380 PSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETA 439
E+V + +P + +E +E + + +V E + +TE+ E+
Sbjct: 778 RPPEKV-------DLEPLKSLDQEIARPLENENQEFLKSLKEESV-EAVKSLETEILESL 829
Query: 440 GSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSE 499
S E L + + +A + E+ QGA ++P EK + +P E V E
Sbjct: 830 KSAGQENLETLKSPETQA-----------PLWTPEEINQGA-MNPLEKEIQEPLESV--E 875
Query: 500 VEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPAD-SPDSQ 558
V +QE ++ ++ S G L E+ + P + +SQ
Sbjct: 876 V----NQETFRLLEEENQESLRSLGAWNL-----------------ENLRSPEEVDKESQ 914
Query: 559 EEQKGESSASSPEEPEEITCLEKGLAEVQQDGEA---EEGATSDGEKKREGVTPWASFKK 615
+ E + E E + LE+ E+ Q + E+ D E +E A +
Sbjct: 915 RNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVEN 974
Query: 616 MVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDT 675
+ +R ++E+ V+ L++TE E+ +G E P+P+E + V+
Sbjct: 975 EDEAELNLREQDGFTGKEEV--VEQGELNATE----EVWIPGEGHPESPEPKEQRGLVE- 1027
Query: 676 SVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKA-------------DEAGKDKE 722
G+S K G D EG + +G +A D+ +
Sbjct: 1028 ----------GASVKGGAEG-LQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGD 1076
Query: 723 TGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSED 782
+ ++ GS +P G S+ P G+GV L T + + LEE+S +
Sbjct: 1077 QASPEVMLGS---EPAMGESA--AGAEPGPGQGVGGLGDPGHL-TREEVMEPPLEEESLE 1130
Query: 783 SIAGSGVEHSTPDTE------------PGK-EESWVSIKKFIPGRRKKRPDGKQEQAPVE 829
+ G+E D E PGK + W ++ + P G +E P E
Sbjct: 1131 AKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAE 1190
Query: 830 DAG----------PTGANEDDSDVPAVV--PLSEYDAVERE------------------- 858
G P G+ E + DVP V+ P Y + +
Sbjct: 1191 TLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQ 1250
Query: 859 -------KMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEE-RS 910
K+E++Q + + + + E + ES+ + + D T + S
Sbjct: 1251 GRAEALGKVESEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTS 1310
Query: 911 PSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAE 970
P W P Q E VL E + E PP+ E E E G +++
Sbjct: 1311 PRWDPTGEQRPPPQGETGKEGWDPAVLASEGL--EAPPSEKEEGEEGEEECG----RDSD 1364
Query: 971 LTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVP 1030
L +E LG E E E + V QL P + +G
Sbjct: 1365 L-------SEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDR-------DGESD 1410
Query: 1031 DIEEQERRTQEVLQAVAEKVKEESQLPGTG--GPEDVLQPVQRAEAERPEEQAEASGL 1086
++E +E E+ +EE + PG G GP + +Q + + E E+ +
Sbjct: 1411 GFADEEESGEE-----GEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSV 1463
Score = 55.1 bits (131), Expect = 6e-07
Identities = 156/796 (19%), Positives = 279/796 (35%), Gaps = 150/796 (18%)
Query: 99 EEEVI--VTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNL 156
E E++ + GQ + E + ++ + T + + ++E E +E + ++
Sbjct: 822 ETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETF 881
Query: 157 EELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHK 216
L + + +G + + P+ V + + E E G G+++
Sbjct: 882 RLLEEENQESLRSLGAWNL------------ENLRSPEEVDKESQRNLEEEENLGKGEYQ 929
Query: 217 DPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESG----------------- 259
+ SL + E +E ++ E+T++++Q A+ SPP +G
Sbjct: 930 E-SLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGF 988
Query: 260 QAVEECKEEGEEKQEKEPSKSAES-PTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKE 318
EE E+GE +E E P SP E + +G A + + +
Sbjct: 989 TGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGA---EGLQDPEGQS 1045
Query: 319 DEVEASEKKKEQ------EPEKVDTEEDGKAEVASEKLTASEQA----------HPQEPA 362
+V A + Q EP D G + + E + SE A P +
Sbjct: 1046 QQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGV 1105
Query: 363 ESAHEPRLSAEYEKVELPSEEQ------VSGSQGPSE--EKPAPLATEVFDEKIEVHQEE 414
+P E +E P EE+ V G +GP + E+ L TE E
Sbjct: 1106 GGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEF---------SE 1156
Query: 415 VVAEVHVSTVEERTEEQKTEVEETAG---SVPAEELVEMDAE-----PQEAEPAKELVKL 466
+ + R +++E E G + PAE L ++ P +E A+E V
Sbjct: 1157 LPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDV-- 1214
Query: 467 KETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLK 526
P SP + + G + E S + VQG + L
Sbjct: 1215 ---------PPVLVSPSPTYTPILEDAPGPQPQAEG-SQEASWGVQG-------RAEALG 1257
Query: 527 KLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEV 586
K+ +++ + G G+ G + +S+E++ GE+ S + +
Sbjct: 1258 KVESEQE--ELGSGEIPEGPQEEGEESREESEEDELGETLPDS----TPLGFYLRSPTSP 1311
Query: 587 QQDGEAEEGATSDGEKKREGVTPWA-SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSS 645
+ D E+ GE +EG P + + + P E ++E D S
Sbjct: 1312 RWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFED 1371
Query: 646 TESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPK 705
T + + G V EP + P+ +D + +W D +G
Sbjct: 1372 L-GTEAPFLPGVPGEVAEPLGQVPQLLLDPA-AW-------------------DRDGESD 1410
Query: 706 AMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVST------- 758
+ + +E +D+E G + G+ PG S + S GE + +
Sbjct: 1411 GFADEEESGEEGEEDQEEGRE---PGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSV 1467
Query: 759 -WESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKK 817
W+ R K+ LE +S+DS SG E +E VS++ R K
Sbjct: 1468 PWDDSLRGAV-AGAPKTALETESQDSAEPSGSE---------EESDPVSLE-----REDK 1512
Query: 818 RPDGKQEQAPVEDAGP 833
P + + +EDAGP
Sbjct: 1513 VPGPLEIPSGMEDAGP 1528
Score = 50.8 bits (120), Expect = 1e-05
Identities = 304/1510 (20%), Positives = 527/1510 (34%), Gaps = 227/1510 (15%)
Query: 307 WRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAH 366
W+++ + + VEA E++K+ ++ +G+ ++A K++ S + + +
Sbjct: 250 WQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEV-------ATY 302
Query: 367 EPRLSAEYEKVELPS--EEQVSGSQGPSEEKPAPLATEV--FDEKIEVHQEEVVAEVHVS 422
L AE +++ P + Q P E P E + V + +
Sbjct: 303 RTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPA 362
Query: 423 TVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADL 482
T+E E P + PQ PA V E Q A L
Sbjct: 363 TLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPA----------VDAEIRAQDAPL 412
Query: 483 SPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDE 542
S L + G E L ++ R+ + S L G ++ G++Q+ G E
Sbjct: 413 S-----LLQTQGGRKQAPEPLRAEARVAIPASVLP------GPEEPGGQRQEASTGQSPE 461
Query: 543 ESGEHTQVPADSPD--SQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDG 600
+ + P SPD S E + GES S + + +G E Q G E+ +G
Sbjct: 462 DHA--SLAPPLSPDHSSLEAKDGESGGS------RVFSICRGEGEGQIWGLVEKETAIEG 513
Query: 601 EKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGS 660
+ +S ++ + ++ + R D + L+K +L + + E
Sbjct: 514 KVV-------SSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHE 566
Query: 661 VEEPKPEEPKRKVDTSVSWEALICVGSSKKRAR------RGSSSDEEGGPKAMGGDHQKA 714
E + +E R ++ + E L + K R + G K G + +
Sbjct: 567 TLERENQECPRSLEEDL--ETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQT 624
Query: 715 DEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKS 774
++ + + L G+ E G+ + E S E ES L ++
Sbjct: 625 LQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQEN-----LESLTALEKENQEPLR 679
Query: 775 KLEEKSEDSIAGSGVEHSTP--DTEPGKEESWVSIKKFIPGRRKKRPDGKQEQA-PVEDA 831
E E+++ E+ P E +E++ S++K K + Q P+E
Sbjct: 680 SPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETE 739
Query: 832 GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHM 891
+ + E + +R + +Q Q + PE K E K L +
Sbjct: 740 NHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPE-KVDLEPLKSLDQEIARP 798
Query: 892 MAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVT 951
+ + ++ ++E S + + TE LE +++ +E LE E + P T
Sbjct: 799 LENENQEFLKS---LKEESVEAVKSLETEILESLKSAG----QENLETLKSPETQAPLWT 851
Query: 952 EPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTD 1011
PE +++ + P E + + T EE E + ++
Sbjct: 852 ---PEE--------INQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWN- 899
Query: 1012 SPDTTEEATPVQEVEG-GVPDIEEQER----RTQEVLQAVAEKVKEESQLPGTGGPEDVL 1066
E +EV+ ++EE+E QE L+++ E+ +E Q ED +
Sbjct: 900 ----LENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTV 955
Query: 1067 QPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEA---KTEPFTQGKVVGQTTPESF--- 1120
+ Q E P A G++ E + L + Q+ K E QG++ T E +
Sbjct: 956 EKDQELAQESPPGMA---GVENEDEAELNLREQDGFTGKEEVVEQGEL--NATEEVWIPG 1010
Query: 1121 EKAPQVTESIESSELVTTCQAETLA-GVKSQEMVMEQAIPPDSVETPTDSETDGSTPVAD 1179
E P+ E E LV + A G++ E +Q P ++ P V D
Sbjct: 1011 EGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAP-GLQAPQGLPEAIEPLVED 1069
Query: 1180 FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKM 1239
APG Q E+ +E A G + G AE P Q + +EE E
Sbjct: 1070 DVAPGGDQASP--EVMLGSEPAMGESAAG--AEPGPGQGVGGLGDPGHLTREEVMEPPLE 1125
Query: 1240 EDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKV 1299
E++LE K V +GLEG R+ +
Sbjct: 1126 EESLEA--KRV-------------------------------QGLEGP--------RKDL 1144
Query: 1300 TEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLE 1359
E G GTE +E L ++ P P RE++EAE EE
Sbjct: 1145 EEAG--GLGTEFSE--------LPGKSRDPWEPPREG------REESEAEAPRGAEEAFP 1188
Query: 1360 HET-AVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQ--EEAVCTKIQVQSS- 1415
ET T S+ S L + + ++V + SP P E+A + Q + S
Sbjct: 1189 AETLGHTGSDAPSPWPLGSE-----EAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQ 1243
Query: 1416 EASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPT 1475
EAS+ + AE + L +GE P G EE E ED D+ P
Sbjct: 1244 EASWGVQGRAEALGKVESEQEELGSGEI--PEGPQEEGEESREESEEDELGETLPDSTPL 1301
Query: 1476 GP----------DCQAKSTPVIVSATTKKGLSSDL---EGEKTTSLKWKSDEVDEQVACQ 1522
G D + P T K+G + EG + + + E E+ +
Sbjct: 1302 GFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGR 1361
Query: 1523 EVKVSVAIEDLEPENGILE-LETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAH 1581
+ +S EDL E L + + ++ + + Q +D + ++ E
Sbjct: 1362 DSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADE------ 1415
Query: 1582 VIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKT 1641
+S + G+E ++EG EP A + + S+ G+ S +S + +
Sbjct: 1416 ---EESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDS 1472
Query: 1642 MTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKG 1701
+ V G+ + L +E + + S E D +L +ED+
Sbjct: 1473 LRGAVAGA-------PKTALETESQDSAEPSGSEEESDPVSL-----------EREDKVP 1514
Query: 1702 DDVDDPENQNSALADTDASG------GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSES 1755
++ P A D G L +S NG E ++EV Q + SE
Sbjct: 1515 GPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVG-QGMPLVSEG 1573
Query: 1756 DKAITPQAQE 1765
D+ Q +E
Sbjct: 1574 DRGSPFQEEE 1583
Score = 35.8 bits (81), Expect = 0.38
Identities = 45/220 (20%), Positives = 98/220 (44%), Gaps = 27/220 (12%)
Query: 1565 EETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVG 1624
+E A LT E Q ++ ++++A + EKE +EP + ++E E+E+
Sbjct: 685 DEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETEN---- 740
Query: 1625 QAHSDIS--KDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHA 1682
H + ++ + + +T+ E + + + +++ L E+ KS+ ++
Sbjct: 741 --HKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQE---- 794
Query: 1683 LLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGL----TKESPDTNGPKQKEK 1738
+A +E E + K + V+ ++ + + ++ S G T +SP+T P +
Sbjct: 795 -IARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPE 853
Query: 1739 EDAQ------EVELQEG----KVHSESDKAITPQAQEELQ 1768
E Q E E+QE +V+ E+ + + + QE L+
Sbjct: 854 EINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLR 893
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 73.9 bits (180), Expect = 1e-12
Identities = 136/643 (21%), Positives = 244/643 (37%), Gaps = 90/643 (13%)
Query: 80 DLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQ 139
DL+ + G GA QE ++ + ++ +D + D KE+ S I D +
Sbjct: 18 DLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRE 77
Query: 140 EETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKD----KTEKPDT 195
+ +E+N EE T + + G K+ F + KD KT KP
Sbjct: 78 TVA------VKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKP-K 130
Query: 196 VQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
V++ + D+ + +K P G+ A K ++ +E+ E+ K+ + + I+
Sbjct: 131 VEMYSGSDDDDD------FNKLPKKAKGK-AQKSNKKWDGSEEDEDNSKKIKERSRINSS 183
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
ESG +E + K +K+ K+ P +E K T KK RK
Sbjct: 184 GESGDESDEFLQ--SRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK 241
Query: 316 PKEDEVEASEKKKEQEPEKVDTEEDGK---------AEVASEKLTASEQAHPQEPAESAH 366
+++E K KE+E + ++ K E K+T P +E
Sbjct: 242 KRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIP--ASEEKA 299
Query: 367 EPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEE 426
E +AE + ++ +G EEK ++ QE ++ ++E
Sbjct: 300 ETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA------LAKLKE 353
Query: 427 RTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDE 486
E QK E EE + L E++A+ +E E L + K ++ + L +
Sbjct: 354 EEERQKREEEER-----IKRLEELEAKRKEEE---RLEQEKRERKKQKEKERKERLKKEG 405
Query: 487 KVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGE 546
K+L+K SQ + + KL + G++ S KR E +
Sbjct: 406 KLLTK-------------SQREARARAEATLKLLQAQGVEVPSKDSLPKKR--PIYEDKK 450
Query: 547 HTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQ-----DGEAEEGATSDGE 601
++P ++ + + + S E + +E+G+ E ++ + E EE G
Sbjct: 451 RKKIP-------QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGL 503
Query: 602 KKREGVTPWASFKKMVTPKKRV---RRPSESDKEDELDKVKSATLSSTESTASEMQEEMK 658
E + +K+ K + P E ++E+E ++ E SE +EE +
Sbjct: 504 DDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEE---------EDEESEEEEEEE 554
Query: 659 GSVEEPKPEEPKRKV-DTSVSWEALICVGSSKKRARRGSSSDE 700
G E + +E KV D S + L KK ++ SS E
Sbjct: 555 GESEGSEGDEEDEKVSDEKDSGKTL-----DKKPSKEMSSDSE 592
Score = 66.6 bits (161), Expect = 2e-10
Identities = 128/650 (19%), Positives = 242/650 (37%), Gaps = 108/650 (16%)
Query: 70 EQDELSLQEGDLNGQKGALNGQGALNSQEE----------EEVIVTEVGQRDSEDVSKRD 119
E +ELSL+ + + + + N++EE ++ DSE++ +D
Sbjct: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
Query: 120 SDKEMATKSAVVHDITDDGQEETPEIIEQIPSS--------------ESNLEELTQPTES 165
S + K V D ++ ++ ++ E N +++ + +
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRI 180
Query: 166 QANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEA 225
++ + +F+ + KK++ KP G + D S
Sbjct: 181 NSSGESGDESDEFLQSRKGQKKNQKNKP------------GPNIESGNEDDDASFKIKTV 228
Query: 226 ASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKS---AE 282
A K++E K+ K + K + + E+G+ + ++E + K E+E KS +
Sbjct: 229 AQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVD 288
Query: 283 SPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGK 342
+ P + E T +KK +K K+ E E EK+K++ P K +
Sbjct: 289 TGVIPASEEKAETPTAAEDDNEGDKKKKD--KKKKKGEKEEKEKEKKKGPSKATVK---A 343
Query: 343 AEVASEKLTASEQAHPQEPAESAHE-PRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLAT 401
+ A KL E+ +E E L A+ ++ E +E+ + +E+ L
Sbjct: 344 MQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKK 403
Query: 402 EVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAE----PQEA 457
E + + Q E A + + Q EV + S+P + + D + PQ+
Sbjct: 404 E--GKLLTKSQRE--ARARAEATLKLLQAQGVEV-PSKDSLPKKRPIYEDKKRKKIPQQL 458
Query: 458 EPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLK 517
E +KE+ + E C + E QG EK + PP VE ++ +
Sbjct: 459 E-SKEVSESMELCAAVEVMEQGV----PEKEETPPP------VEPEEEEDTEDAGLDDWE 507
Query: 518 KLFTSTGLKKLSGKKQ--KGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEE 575
+ + +K+ G K + K +EE E + + + +EE++GES S +E +E
Sbjct: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDE 567
Query: 576 ITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDEL 635
+ E + G T D + P K + SE D +D+
Sbjct: 568 -----------KVSDEKDSGKTLDKK-----------------PSKEMSSDSEYDSDDDR 599
Query: 636 DKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICV 685
K + A ++ K +E+ + E K V+T +ICV
Sbjct: 600 TKEERA------------YDKAKRRIEKRRLEHSK-NVNTEKLRAPIICV 636
Score = 54.7 bits (130), Expect = 8e-07
Identities = 114/619 (18%), Positives = 238/619 (38%), Gaps = 68/619 (10%)
Query: 317 KEDEVEASEKKKEQEPEKVDTEEDG------KAEVASEKLTASEQAHPQEPAESAHEPRL 370
KE E + S+ KK++E +K D +ED + + ++ + A + +P E+ E
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 371 SAEYEKVELPSEEQVSGSQGPSEE---------KPAPLATEVFDEKIEVHQEEVVAEVHV 421
S + +K ++Q S SEE K A E++ + + +
Sbjct: 93 SKDKKKKGQKGKKQ-SFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAK 151
Query: 422 STVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGAD 481
++ ++ E+ S +E +++ + + + E ++ ++ + G +
Sbjct: 152 GKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPN 211
Query: 482 LSP--DEKVLSKPPEGVVSEVEMLSSQERMK--VQGSPLKKLFTSTGLKKLSGKKQKGKR 537
+ ++ S + V + +ER K + + L+KL L+ +GKK + K+
Sbjct: 212 IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELE--TGKKDQSKQ 269
Query: 538 GGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGAT 597
+ E T + D+ E A +P E+ +K ++D + ++G
Sbjct: 270 KESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDK----KKKDKKKKKGEK 325
Query: 598 SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEM 657
+ EK+++ A+ K M +++ E K +E +++K L E+ E +E +
Sbjct: 326 EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIK--RLEELEAKRKE-EERL 382
Query: 658 KGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSS-----------SDEEGGPKA 706
+ E K ++ K + + L+ + RAR ++ ++ PK
Sbjct: 383 EQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKK 442
Query: 707 M----GGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSP--------TEGE 754
+K + + KE L + E QG E+ P TE
Sbjct: 443 RPIYEDKKRKKIPQQLESKEVSESMELCAAVE-VMEQGVPEKEETPPPVEPEEEEDTEDA 501
Query: 755 GVSTWESFKRLVTPRKKSKSK----LEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKF 810
G+ WE+ K +K ++E E+ E ++E +EE S
Sbjct: 502 GLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGES---- 557
Query: 811 IPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAE 870
+ +G +E V D +G D + SEYD+ + ++ + ++A A+
Sbjct: 558 ------EGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS-DDDRTKEERAYDKAK 610
Query: 871 QPEQKAATEVSKELSESQV 889
+ +K E SK ++ ++
Sbjct: 611 RRIEKRRLEHSKNVNTEKL 629
Score = 39.7 bits (91), Expect = 0.026
Identities = 94/492 (19%), Positives = 183/492 (37%), Gaps = 71/492 (14%)
Query: 1234 KEQSKMEDTLEHTDKEVSVETVS-ILSKTEGTQEADQYA--------DEKTKDVPFFEGL 1284
K K + + E D ++ S I S E E+D++ ++K K P E
Sbjct: 156 KSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESG 215
Query: 1285 EGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVERE 1344
D K+ VA K +E E KK D E + ++ +E
Sbjct: 216 NEDDDASF-----KIKTVAQKKAEKKERERKKRD---------------EEKAKLRKLKE 255
Query: 1345 KTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEE 1404
K E E T ++ + E+ EE K + TV+ +I ++E + +P E
Sbjct: 256 KEELE-TGKKDQSKQKESQRKFEEETVKSKV-TVDTGVIPASEEKAE---TPTAAEDDNE 310
Query: 1405 AVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDF 1464
K + + E+EK G + T + ++ A A L EE+ ++ E
Sbjct: 311 GDKKKKDKKKKKGE---KEEKEKEKKKGPSK---ATVKAMQEALAKLKEEEERQKREE-- 362
Query: 1465 AAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEV 1524
E+ + + +AK K+ E E+ LK + + +
Sbjct: 363 -----EERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARA 417
Query: 1525 KVSVAIEDLEPENGILELETKSS-----KLVQNIIQTAVDQFVRTEETATEM-LTSELQT 1578
+ ++ L+ + +E+ +K S + ++ + + Q + ++E + M L + ++
Sbjct: 418 RAEATLKLLQAQG--VEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEV 475
Query: 1579 QAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEAS 1638
+ + +E E+ + + D+ ++ EE+E + H ++ ++ E
Sbjct: 476 MEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEE 535
Query: 1639 EKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPED-------DGHALLAERIEKS 1691
E+ E D++ EE EEEG G++ ED D L ++ K
Sbjct: 536 EE------EEEEEEDEESEE---EEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKE 586
Query: 1692 LVEPKEDEKGDD 1703
+ E + DD
Sbjct: 587 MSSDSEYDSDDD 598
Score = 34.3 bits (77), Expect = 1.1
Identities = 125/659 (18%), Positives = 237/659 (35%), Gaps = 105/659 (15%)
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEA--ERPEEQAEA 1083
E D + + E+ A A K +E + G E Q + E E EA
Sbjct: 10 EDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEA 69
Query: 1084 SGLKKETDVVLKVDAQEAKTEPFTQG--KVVGQT-TPESFEK--APQVTESIESSELVTT 1138
G+K + + V V E E FT K GQ +SF+ + ++ + S+
Sbjct: 70 QGIKADRETVA-VKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAK 128
Query: 1139 CQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEEN 1198
+ E +G + + ++ + DGS +D +I E +
Sbjct: 129 PKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEE----------DEDNSKKIKERS 178
Query: 1199 EVASGTQSGGTEAEAVPAQK------ERPPAPS--------SFVFQEETKEQSKMEDTLE 1244
+ S +SG E + ++K + P P+ F+ +T Q K E +
Sbjct: 179 RINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEK--K 236
Query: 1245 HTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEG-------SIDTGITVSRE 1297
+++ E + L K + +E + +++K E ++DTG+ + E
Sbjct: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE 296
Query: 1298 KVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEK 1357
+ E E E + KK D + + E+E E+EK + + K
Sbjct: 297 EKAETPTAAEDDNEGDKKKKDKKKKKG---------EKE-----EKEKEKKKGPSKATVK 342
Query: 1358 LEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEA 1417
E + EE +Q + + K + LE +EE +++ +
Sbjct: 343 AMQEALAKLKEEEERQKREEE-----ERIKRLEELEAKRK----EEE------RLEQEKR 387
Query: 1418 SFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGP 1477
E ++ L + +L + A A L+ ++ E P +D++P
Sbjct: 388 ERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEV----PSKDSLP--- 440
Query: 1478 DCQAKSTPVIVSATTKKGLSSDLEGEKTTSLK--WKSDEVDEQVACQEVKVSVAIEDLEP 1535
K P+ KK + LE ++ + + EV EQ ++ + +E E
Sbjct: 441 ----KKRPIYEDKKRKK-IPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEE 495
Query: 1536 EN----GILELETKSS-----KLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKAD 1586
E+ G+ + E +S K+ N + V + EE E + +
Sbjct: 496 EDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEE------------EEE 543
Query: 1587 SQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVE 1645
+++ +E E+EGE + +E S +++S T + ++S D S+ T E
Sbjct: 544 DEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKE 602
Score = 32.7 bits (73), Expect = 3.2
Identities = 118/602 (19%), Positives = 216/602 (35%), Gaps = 95/602 (15%)
Query: 1210 EAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSI--------LSKT 1261
E E A KE+ P S ++E K+Q ED + +E+S+E I + T
Sbjct: 25 EIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPT 84
Query: 1262 EGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALE 1321
E +E D+K K +G + S D E++ + K + T + + + +
Sbjct: 85 ENNEEEFTSKDKKKKGQ---KGKKQSFDDN---DSEELEDKDSKSKKTAKPKVEMYSGSD 138
Query: 1322 LQSHAKSPPSPVEREMVVQVEREKTE-AEPTHVNEEKLEHETAVTVSEEV---SKQLLQT 1377
P + + Q +K + +E N +K++ + + S E S + LQ+
Sbjct: 139 DDDDFNKLPKKAKGK--AQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQS 196
Query: 1378 VNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAA---------EEE 1428
G K+ + P G E+ +ASF + A E +
Sbjct: 197 RK-----GQKKNQKNKPGPNIESGNED----------DDASFKIKTVAQKKAEKKERERK 241
Query: 1429 KVLGETANI--LETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTG--PDCQAKST 1484
K E A + L+ E LE G ++K S++ + + V TG P + K
Sbjct: 242 KRDEEKAKLRKLKEKEELE-TGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEK-- 298
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A T D EG+K K K E+ ++ E + G +
Sbjct: 299 -----AETPTAAEDDNEGDKKKKDKKKKKGEKEE------------KEKEKKKGPSKATV 341
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQAS 1604
K+ + ++ ++ R EE + L + + + + ++ +KE E +
Sbjct: 342 KAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERL 401
Query: 1605 AQDETPITSAKEESESTAVG-----QAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEV 1659
++ +T ++ E+ + A QA +K E + QQLE
Sbjct: 402 KKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLE-- 459
Query: 1660 VLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDA 1719
+K V E E +E+ + E +E + ++ E+ A D
Sbjct: 460 ------------SKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507
Query: 1720 SGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSEL 1779
+ +E+ G K + E +E + E D EE +++E E +SE
Sbjct: 508 AMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEED--------EESEEEEEEEGESEG 559
Query: 1780 TE 1781
+E
Sbjct: 560 SE 561
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 73.6 bits (179), Expect = 2e-12
Identities = 115/543 (21%), Positives = 205/543 (37%), Gaps = 85/543 (15%)
Query: 187 KDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKP----EET 242
+D +E+ + VQ KK A K L G+AA+K SE S E EE
Sbjct: 88 EDSSEEEEEVQGPPAKK-------AAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEED 140
Query: 243 LKREQSHAEISPPAESGQA----VEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKK 298
K++ + P A++ +A + + + E EP K+ + +PVT + +
Sbjct: 141 QKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPP 200
Query: 299 FFTQGWAGWRKKTSFRKPK-EDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAH 357
K + PK + AS D E+ KA +K +Q
Sbjct: 201 -----------KPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVV 249
Query: 358 PQEPAESAHEP-RLSAEYEKVELPSEEQ----VSGSQGPSEEKPAP--------LATEVF 404
+ P ++A P R S+ E EE+ + GP P P L T+
Sbjct: 250 AKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPP 309
Query: 405 DEKIEVHQ-----EEVVAEVHVSTVEERTEEQKTEVEE-TAGSVPAEELVEMDAEPQEAE 458
+ +E Q E+ E S+ EE+ K V + T PA++ E ++ +++
Sbjct: 310 KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSD 369
Query: 459 -------PAKELVKLKETCVSGEDPTQGADLSP----------DEKVLSKPPEGVVSEVE 501
P+K K + T+ + P +K+L++ + SE E
Sbjct: 370 SSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEE 429
Query: 502 MLSSQE-RMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEE 560
SS+E + K + K T+ L K+ +G D S +DS S+EE
Sbjct: 430 SSSSEEEKTKKMVATTKPKATAKAALSLPAKQ--APQGSRDSSSD------SDSSSSEEE 481
Query: 561 QKGESSASSPEEPEEIT---------CLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWA 611
++ S ++ ++P+++ +KG AE +++ + + EK + +P
Sbjct: 482 EEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRP 541
Query: 612 SFKKM----VTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPE 667
K + + S++E+E K + +S + S Q E E P+ +
Sbjct: 542 QAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAK 601
Query: 668 EPK 670
+ K
Sbjct: 602 KIK 604
Score = 64.7 bits (156), Expect = 8e-10
Identities = 130/629 (20%), Positives = 245/629 (38%), Gaps = 100/629 (15%)
Query: 46 IAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVT 105
+ A+ P K +K S + ++ S +E ++ G A
Sbjct: 68 LQANGPVAKKAKKKASSS------DSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAA 121
Query: 106 EVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQE-ETPEIIEQIPSSESNLEELTQPTE 164
+ + S + S D D+E K V + + + P + S+S+ +P +
Sbjct: 122 KASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPK 181
Query: 165 SQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGE 224
+Q I V K +T+ P K G+ A+ + S +
Sbjct: 182 NQKPKITPVTV-----------KAQTKAPPKPARAAPKIANGKAASSS------SSSSSS 224
Query: 225 AASKESEPKQSTEKPEETLKREQSHAEI-----SPPAESGQAVEECKEEGEEKQEKEPSK 279
++S +SE +++ P++T+ ++Q A+ + P + E+ + EE+++K+P K
Sbjct: 225 SSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSD-EEEEQKKPMK 283
Query: 280 SAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEE 339
+ P S V + KK + G +K ++P VE+SE ++ + E+
Sbjct: 284 NKPGPYSSVPPPSAPPPKK--SLGTQPPKKAVEKQQP----VESSEDSSDESDSSSEEEK 337
Query: 340 DGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPA-- 397
+ K T ++ ++ AES+ + S E E PS+ +G+ S KPA
Sbjct: 338 KPPTKAVVSKAT-TKPPPAKKAAESSSDSSDSDSSEDDEAPSKP--AGTTKNSSNKPAVT 394
Query: 398 ---PLATEVFDEKIEVH--QEEVVAEVHVSTVEERT---EEQKTE----------VEETA 439
P K V Q+ + + S+ EE + EE+KT+ + A
Sbjct: 395 TKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAA 454
Query: 440 GSVPAEELVE-----------MDAEPQEAEPAKELVKLKETCVSG-EDPTQGADLSPDEK 487
S+PA++ + +E +E + +K VK K V+G P++ A +
Sbjct: 455 LSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKA 514
Query: 488 VLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEH 547
S S E +E++K +GSP + + G L+ Q GK EE
Sbjct: 515 ESSNSSSSDDSSEE---EEEKLKGKGSPRPQAPKANGTSALTA--QNGKAAKNSEE---- 565
Query: 548 TQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGV 607
+EE+K +++ + + G + ++ EA + A + KK +
Sbjct: 566 ----------EEEEKKKAA---------VVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQ 606
Query: 608 TPWASFKKMVTPKKRVRRPSESDKEDELD 636
TP +F K +KR P +E+E++
Sbjct: 607 TP-NTFPKRKKGEKRASSPFRRVREEEIE 634
Score = 61.6 bits (148), Expect = 7e-09
Identities = 108/506 (21%), Positives = 185/506 (36%), Gaps = 35/506 (6%)
Query: 504 SSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKG 563
SS+E +VQG P KK + K++ K + S E + S D EE +
Sbjct: 90 SSEEEEEVQGPPAKK--AAVPAKRVGLPPGKAAAKASESSSSEES-----SDDDDEEDQK 142
Query: 564 ESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREG-VTPWASFKKMVTPKKR 622
+ +P+ D +++ + + K ++ +TP + P K
Sbjct: 143 KQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPK- 201
Query: 623 VRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEAL 682
P+ + + K S++ SS+ S++S+ EE K + PK PK++V +A
Sbjct: 202 ---PARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAAT-PKKTVPKKQVVAKAPVKAA 257
Query: 683 ICVGSSKKRARRGSSSDEEGGPKAM---GGDHQKADEAG---KDKETGTDGILAGSQEHD 736
+ SS +EE K M G + K GT ++
Sbjct: 258 TTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQ 317
Query: 737 PGQGS-SSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPD 795
P + S S +++ S +E E ++ T + K E S DS S + S D
Sbjct: 318 PVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDS---SDSDSSEDD 374
Query: 796 TEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAV 855
P K P K P K AP + P G + A SE
Sbjct: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQ---PVGGGQKLLTRKADSSSSE---E 428
Query: 856 EREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS 915
E E ++ +K + KA + + L Q + + + +++ EE + S
Sbjct: 429 ESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKS 488
Query: 916 ASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEA 975
A +P Q A A ++ ++ AE + ++ E E + + + P+A
Sbjct: 489 AVKKKP--QKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEE---EKLKGKGSPRPQA 543
Query: 976 VTAAETAGPLGAEEGTEASAAEETTE 1001
A T+ L A+ G A +EE E
Sbjct: 544 PKANGTSA-LTAQNGKAAKNSEEEEE 568
Score = 47.0 bits (110), Expect = 2e-04
Identities = 44/162 (27%), Positives = 72/162 (44%), Gaps = 29/162 (17%)
Query: 191 EKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEA-ASKESEPKQSTEKPEETLKREQSH 249
E+ + VKK + A GA K S G+A +S S S+E+ EE LK + S
Sbjct: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
Query: 250 AEISP--------PAESGQAVEECKEEGEEK----------------QEKEPSKSAESP- 284
+P A++G+A + +EE EEK ++ E +K AE+P
Sbjct: 540 RPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQ 599
Query: 285 TSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEK 326
+ +T +TF K + R + FR+ +E+E+E +
Sbjct: 600 AKKIKLQTPNTFPK---RKKGEKRASSPFRRVREEEIEVDSR 638
Score = 44.3 bits (103), Expect = 0.001
Identities = 122/630 (19%), Positives = 225/630 (35%), Gaps = 90/630 (14%)
Query: 931 LLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEG 990
L + +V ER++ A + + ++ + E P A AA A +G G
Sbjct: 58 LKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPG 117
Query: 991 TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKV 1050
A+ A E++ ++EE++ D +E++++ Q V + V +
Sbjct: 118 KAAAKASESS--------------SSEESSD---------DDDEEDQKKQPVQKGVKPQA 154
Query: 1051 KEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGK 1110
K P D +E E P+ Q K T V +K + K
Sbjct: 155 KAAKAPPKKAKSSDS-DSDSSSEDEPPKNQKP-----KITPVTVKAQTKAPPKPARAAPK 208
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ S + + S +S E E A + + +Q + V+ T
Sbjct: 209 IANGKAASSSSSSSSSSSSDDSEE-------EKAAATPKKTVPKKQVVAKAPVKAAT--- 258
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
TP + + DE E + + G S A P +K P +
Sbjct: 259 ----TPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVE 314
Query: 1231 EETKEQSKMEDTLEHTDKEVSVE----TVSILSKTEGTQEADQYADEKTKDVPFFEGLEG 1286
++ +S ED+ + +D E T +++SK TK P + E
Sbjct: 315 KQQPVESS-EDSSDESDSSSEEEKKPPTKAVVSKAT------------TKPPPAKKAAES 361
Query: 1287 SIDTGITVSREKVTEVALKGEGTEE------AECKKDDALELQSHAKSPPSPVEREMVVQ 1340
S D+ + S E E K GT + A K A++ + K P ++ + +
Sbjct: 362 SSDSSDSDSSED-DEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRK 420
Query: 1341 VEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCL 1400
+ +E E + EEK + A T + +K L G+++ SS S
Sbjct: 421 ADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSS--DSDSSSS 478
Query: 1401 GQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEK 1460
+EE +K V+ + +KV G A +PA A E S+
Sbjct: 479 EEEEEKTSKSAVKK-----------KPQKVAGGAA-------PSKPASAKKGKAESSNSS 520
Query: 1461 NEDFAAHPGEDAV--PTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQ 1518
+ D ++ E+ + P QA + T + G ++ E+ K + V +
Sbjct: 521 SSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKS 580
Query: 1519 VACQEVKVSVAIEDLE-PENGILELETKSS 1547
+ ++ K + A ++ E P+ ++L+T ++
Sbjct: 581 GSLKKRKQNEAAKEAETPQAKKIKLQTPNT 610
Score = 43.5 bits (101), Expect = 0.002
Identities = 119/617 (19%), Positives = 207/617 (33%), Gaps = 114/617 (18%)
Query: 1176 PVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKER-PPAPSSFVFQEETK 1234
PVA + D EE EV Q + AVPA++ PP ++ E +
Sbjct: 73 PVAKKAKKKASSSDSEDSSEEEEEV----QGPPAKKAAVPAKRVGLPPGKAAAKASESSS 128
Query: 1235 EQSKMEDTLEHTDKEVSVE----------------TVSILSKTEGTQEADQYADEKTKDV 1278
+ +D E K+ V+ S S ++ + E + ++K K
Sbjct: 129 SEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKIT 188
Query: 1279 PFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMV 1338
P + + K+ + + D E + A +P V ++ V
Sbjct: 189 PVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQV 248
Query: 1339 VQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTV-----NVPIIDGAKEVSSLE 1393
V K PT + E + + EE K+ ++ +VP SL
Sbjct: 249 VAKAPVKAATTPTRKSSSS---EDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLG 305
Query: 1394 GSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVL 1453
PP ++AV + V+SSE S + ++ EE+ T ++ T P
Sbjct: 306 TQPP-----KKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA----- 355
Query: 1454 EEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSD 1513
+K++E + D + + D +A S P + TTK + K+ +
Sbjct: 356 -KKAAESSSDSSDSDSSE------DDEAPSKP---AGTTKNSSNKPAVTTKSPA------ 399
Query: 1514 EVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLT 1573
V A +P G +L T+
Sbjct: 400 ------------VKPAAAPKQPVGGGQKLLTR---------------------------- 419
Query: 1574 SELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKD 1633
KADS + +E+ EE T + + + S QA S+D
Sbjct: 420 ----------KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQG-SRD 468
Query: 1634 MSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLV 1693
S S+ + + E E T ++ P + GG A +K G A +
Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKK---PQKVAGGAAPSKPASAKKGKAESSNSSSSDDS 525
Query: 1694 EPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEV-----ELQE 1748
+E+EK P Q T A ++ + +++EK+ A V L++
Sbjct: 526 SEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKK 585
Query: 1749 GKVHSESDKAITPQAQE 1765
K + + +A TPQA++
Sbjct: 586 RKQNEAAKEAETPQAKK 602
Score = 34.3 bits (77), Expect = 1.1
Identities = 39/201 (19%), Positives = 78/201 (38%), Gaps = 18/201 (8%)
Query: 1584 KADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMT 1643
KA S D+ ++ E E P+ TP+T + +A I+ + +S + +
Sbjct: 163 KAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSS 222
Query: 1644 VEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEP-KEDEKGD 1702
S+ +D + EE+ K+VP+ ++A+ K+ P ++ +
Sbjct: 223 ---SSSSSDDSE--------EEKAAATPKKTVPKKQ---VVAKAPVKAATTPTRKSSSSE 268
Query: 1703 DVDDPENQNSALADTDASGGLTKESPDTNGPKQKE---KEDAQEVELQEGKVHSESDKAI 1759
D E + + G + P + P +K + + VE Q+ SE
Sbjct: 269 DSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDE 328
Query: 1760 TPQAQEELQKQERESAKSELT 1780
+ + EE +K ++ S+ T
Sbjct: 329 SDSSSEEEKKPPTKAVVSKAT 349
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 224 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 278
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 338
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1520
Query: 339 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 388 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 445
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1639
Query: 446 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 505
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 506 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 560
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1750
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 617
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 618 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 673
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1871 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1916
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
Q + E E L R ++ L K + + +
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2010
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 905
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2011 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2070 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
+A+ +A AAE +E + AE+ +++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2160
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 1080
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 1081 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1129
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2221 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2278
Query: 1130 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2279 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2326
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1245
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2327 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2373
Query: 1246 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1305
E+S E + + A A+E + R++ E+ K
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2416
Query: 1306 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2475
Query: 1363 AVTVSEEVSKQLLQ 1376
TV +E QLLQ
Sbjct: 2476 MQTVQQE---QLLQ 2486
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 489
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1434
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1479
Query: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 609
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1534
Query: 610 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 669
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1592
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 729
+R + E + V ++ A R + E + + K E +
Sbjct: 1593 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1700
Query: 790 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1701 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 909
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 910 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 969
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1870
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1871 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1913
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 1086
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1914 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1970
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1144
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1971 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2024
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1201
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2083
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2139
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2191
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1376
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2248
Query: 1377 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1427
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2305
Query: 1428 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1484
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2352
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2408
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1603
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2409 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
A K + SE+ TV+ E Q L++ L S
Sbjct: 2465 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2497
Query: 1664 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1721
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2556
Query: 1722 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1772
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2606
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 831 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 891 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 945
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 946 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 1002
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 1058
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1237 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1293
Query: 1059 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1110
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1294 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1404
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1405 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1451
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1290
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1505
Query: 1291 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1350
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1557
Query: 1351 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1410
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1558 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1606
Query: 1411 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1470
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1607 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1658
Query: 1471 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1530
QA++ A + E + + E+++Q +++ A
Sbjct: 1659 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1706
Query: 1531 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1765
Query: 1589 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1642
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 1643 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1883
Query: 1692 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1742
+ K D K D + E Q + DT + +E +K
Sbjct: 1884 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1743 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Score = 45.8 bits (107), Expect = 4e-04
Identities = 189/1016 (18%), Positives = 381/1016 (37%), Gaps = 118/1016 (11%)
Query: 91 QGALNSQEEEEVIVTE----VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEII 146
+ A + E E ++ E +G+ + KE ++ + + +D + +
Sbjct: 1822 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 147 EQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDE 205
EQ ++++EE L Q ++ +++ +K G + + + + ++L +K
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQK-----GLVEDTLRQRRQVEE--EILALKASF 1934
Query: 206 GEGAAGAGD----------HKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
+ AAG + + + +L + E A E+ ++ EE +RE
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +A + K EE E+ +K E+ +E S + Q A ++ + K
Sbjct: 1995 AAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE-AAQKRLQAEEK 2052
Query: 316 PKEDEVEASEKKKEQEPEKVDTEED---GKAEVASEKLTASEQAHPQEPAESAHEPRLSA 372
V+ E++ +Q ++ + D G+AE A +E+A Q E+A R
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 373 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQK 432
E E+++ +EEQ ++ ++ L E E Q E A + E+ K
Sbjct: 2113 EAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 433 TEVEET--AGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 490
E+T + +EL + + +E + K L+ + + E S E+ L
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 491 KPPEGVVSEVEMLSS-QERMKVQGSPL--------KKLFTSTGLKKLSGKKQKGKRGGGD 541
V ++E LS + R++ + L ++ K ++ +
Sbjct: 2232 ----SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 542 EESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGE-AEEGATSDG 600
+E+ Q+ + Q + + +E T L+ +QQ E A+E A
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 601 EKKREGVTPWA----SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEE 656
E K + A F++ + ++ +R E E E K++ A +S ++ A E +
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 657 MKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG---GDHQK 713
+ EE + + T ++ + + + + + R+ S D E +A+ + +K
Sbjct: 2406 FRKQAEEIGEKLHR----TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
+ K + ++ + QE + + Q +E + + E F ++ K
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERF------IEQEK 2513
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGP 833
+KLE+ +D +A + +EE +R+++ ++ Q V
Sbjct: 2514 AKLEQLFQDEVA---------KAQQLREEQ----------QRQQQQMEQERQRLVASMEE 2554
Query: 834 TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK-----ELSESQ 888
+ +++ + V R++ E QQ ++ Q E+ A E + +L E Q
Sbjct: 2555 ARRRQHEAE----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 889 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE-EP 947
H A A ++ A+ + ++ ++ P + E E + + L R+V A+ +
Sbjct: 2605 -HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQE 2660
Query: 948 PTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVS 1007
+ R A+G T V E + + + G A E + +A+
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA---GLLLKATNEKLSVYAALQ 2717
Query: 1008 QLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ SP T Q G + D R T V E VKE G GPE
Sbjct: 2718 RQLLSPGTALILLEAQAASGFLLDPVRNRRLT------VNEAVKE-----GVVGPE 2762
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 224 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 278
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1410 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1468
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 338
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1469 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1524
Query: 339 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Query: 388 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 445
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1643
Query: 446 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 505
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 506 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 560
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1754
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 617
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1755 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814
Query: 618 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 673
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1875 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1920
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
Q + E E L R ++ L K + + +
Sbjct: 1921 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1980
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1981 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2014
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 905
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2015 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2074 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
+A+ +A AAE +E + AE+ +++
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2164
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 1080
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2224
Query: 1081 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1129
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2225 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2282
Query: 1130 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2283 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2330
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1245
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2331 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2377
Query: 1246 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1305
E+S E + + A A+E + R++ E+ K
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2420
Query: 1306 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2479
Query: 1363 AVTVSEEVSKQLLQ 1376
TV +E QLLQ
Sbjct: 2480 MQTVQQE---QLLQ 2490
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 489
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1438
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1483
Query: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 609
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1538
Query: 610 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 669
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1596
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 729
+R + E + V ++ A R + E + + K E +
Sbjct: 1597 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1704
Query: 790 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1705 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 909
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1758 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1817
Query: 910 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 969
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1818 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1874
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1875 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1917
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 1086
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1918 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1974
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1144
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1975 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2028
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1201
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2029 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2087
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2143
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2144 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2195
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1376
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2252
Query: 1377 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1427
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2309
Query: 1428 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1484
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2310 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2356
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2357 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2412
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1603
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2413 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
A K + SE+ TV+ E Q L++ L S
Sbjct: 2469 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2501
Query: 1664 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1721
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2502 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2560
Query: 1722 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1772
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2610
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 831 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1063 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1122
Query: 891 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 945
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1180
Query: 946 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 1002
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1181 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1240
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 1058
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1241 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1297
Query: 1059 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1110
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1298 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1353
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1354 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1408
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1409 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1455
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1290
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1509
Query: 1291 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1350
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1561
Query: 1351 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1410
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1562 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1610
Query: 1411 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1470
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1611 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1662
Query: 1471 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1530
QA++ A + E + + E+++Q +++ A
Sbjct: 1663 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1710
Query: 1531 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1711 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1769
Query: 1589 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1642
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1829
Query: 1643 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1887
Query: 1692 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1742
+ K D K D + E Q + DT + +E +K
Sbjct: 1888 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 1743 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982
Score = 45.8 bits (107), Expect = 4e-04
Identities = 189/1016 (18%), Positives = 381/1016 (37%), Gaps = 118/1016 (11%)
Query: 91 QGALNSQEEEEVIVTE----VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEII 146
+ A + E E ++ E +G+ + KE ++ + + +D + +
Sbjct: 1826 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1885
Query: 147 EQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDE 205
EQ ++++EE L Q ++ +++ +K G + + + + ++L +K
Sbjct: 1886 EQAAQHKADIEERLAQLRKASDSELERQK-----GLVEDTLRQRRQVEE--EILALKASF 1938
Query: 206 GEGAAGAGD----------HKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
+ AAG + + + +L + E A E+ ++ EE +RE
Sbjct: 1939 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1998
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +A + K EE E+ +K E+ +E S + Q A ++ + K
Sbjct: 1999 AAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE-AAQKRLQAEEK 2056
Query: 316 PKEDEVEASEKKKEQEPEKVDTEED---GKAEVASEKLTASEQAHPQEPAESAHEPRLSA 372
V+ E++ +Q ++ + D G+AE A +E+A Q E+A R
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116
Query: 373 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQK 432
E E+++ +EEQ ++ ++ L E E Q E A + E+ K
Sbjct: 2117 EAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 433 TEVEET--AGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 490
E+T + +EL + + +E + K L+ + + E S E+ L
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2235
Query: 491 KPPEGVVSEVEMLSS-QERMKVQGSPL--------KKLFTSTGLKKLSGKKQKGKRGGGD 541
V ++E LS + R++ + L ++ K ++ +
Sbjct: 2236 ----SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2291
Query: 542 EESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGE-AEEGATSDG 600
+E+ Q+ + Q + + +E T L+ +QQ E A+E A
Sbjct: 2292 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2351
Query: 601 EKKREGVTPWA----SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEE 656
E K + A F++ + ++ +R E E E K++ A +S ++ A E +
Sbjct: 2352 EDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Query: 657 MKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG---GDHQK 713
+ EE + + T ++ + + + + + R+ S D E +A+ + +K
Sbjct: 2410 FRKQAEEIGEKLHR----TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2465
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
+ K + ++ + QE + + Q +E + + E F ++ K
Sbjct: 2466 LQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERF------IEQEK 2517
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGP 833
+KLE+ +D +A + +EE +R+++ ++ Q V
Sbjct: 2518 AKLEQLFQDEVA---------KAQQLREEQ----------QRQQQQMEQERQRLVASMEE 2558
Query: 834 TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK-----ELSESQ 888
+ +++ + V R++ E QQ ++ Q E+ A E + +L E Q
Sbjct: 2559 ARRRQHEAE----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2608
Query: 889 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE-EP 947
H A A ++ A+ + ++ ++ P + E E + + L R+V A+ +
Sbjct: 2609 -HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQE 2664
Query: 948 PTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVS 1007
+ R A+G T V E + + + G A E + +A+
Sbjct: 2665 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA---GLLLKATNEKLSVYAALQ 2721
Query: 1008 QLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ SP T Q G + D R T V E VKE G GPE
Sbjct: 2722 RQLLSPGTALILLEAQAASGFLLDPVRNRRLT------VNEAVKE-----GVVGPE 2766
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 224 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 278
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1406 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1464
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 338
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1465 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1520
Query: 339 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 388 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 445
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1639
Query: 446 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 505
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 506 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 560
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1750
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 617
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1751 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 618 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 673
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1871 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1916
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
Q + E E L R ++ L K + + +
Sbjct: 1917 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1976
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1977 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2010
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 905
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2011 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2070 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
+A+ +A AAE +E + AE+ +++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2160
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 1080
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Query: 1081 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1129
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2221 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2278
Query: 1130 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2279 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2326
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1245
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2327 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2373
Query: 1246 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1305
E+S E + + A A+E + R++ E+ K
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2416
Query: 1306 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2475
Query: 1363 AVTVSEEVSKQLLQ 1376
TV +E QLLQ
Sbjct: 2476 MQTVQQE---QLLQ 2486
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 489
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1434
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1479
Query: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 609
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1534
Query: 610 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 669
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1592
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 729
+R + E + V ++ A R + E + + K E +
Sbjct: 1593 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1700
Query: 790 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1701 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 909
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1754 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1813
Query: 910 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 969
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1814 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1870
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1871 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1913
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 1086
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1914 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1970
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1144
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1971 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2024
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1201
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2025 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2083
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2139
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2140 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2191
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1376
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2248
Query: 1377 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1427
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2305
Query: 1428 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1484
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2352
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2353 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2408
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1603
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2409 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
A K + SE+ TV+ E Q L++ L S
Sbjct: 2465 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2497
Query: 1664 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1721
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2556
Query: 1722 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1772
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2606
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 831 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1059 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1118
Query: 891 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 945
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1176
Query: 946 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 1002
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 1058
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1237 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1293
Query: 1059 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1110
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1294 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1349
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1350 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1404
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1405 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1451
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1290
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1505
Query: 1291 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1350
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1557
Query: 1351 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1410
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1558 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1606
Query: 1411 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1470
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1607 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1658
Query: 1471 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1530
QA++ A + E + + E+++Q +++ A
Sbjct: 1659 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1706
Query: 1531 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1707 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1765
Query: 1589 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1642
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 1643 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1883
Query: 1692 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1742
+ K D K D + E Q + DT + +E +K
Sbjct: 1884 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 1743 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Score = 45.8 bits (107), Expect = 4e-04
Identities = 189/1016 (18%), Positives = 381/1016 (37%), Gaps = 118/1016 (11%)
Query: 91 QGALNSQEEEEVIVTE----VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEII 146
+ A + E E ++ E +G+ + KE ++ + + +D + +
Sbjct: 1822 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1881
Query: 147 EQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDE 205
EQ ++++EE L Q ++ +++ +K G + + + + ++L +K
Sbjct: 1882 EQAAQHKADIEERLAQLRKASDSELERQK-----GLVEDTLRQRRQVEE--EILALKASF 1934
Query: 206 GEGAAGAGD----------HKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
+ AAG + + + +L + E A E+ ++ EE +RE
Sbjct: 1935 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1994
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +A + K EE E+ +K E+ +E S + Q A ++ + K
Sbjct: 1995 AAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE-AAQKRLQAEEK 2052
Query: 316 PKEDEVEASEKKKEQEPEKVDTEED---GKAEVASEKLTASEQAHPQEPAESAHEPRLSA 372
V+ E++ +Q ++ + D G+AE A +E+A Q E+A R
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 373 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQK 432
E E+++ +EEQ ++ ++ L E E Q E A + E+ K
Sbjct: 2113 EAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 433 TEVEET--AGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 490
E+T + +EL + + +E + K L+ + + E S E+ L
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 491 KPPEGVVSEVEMLSS-QERMKVQGSPL--------KKLFTSTGLKKLSGKKQKGKRGGGD 541
V ++E LS + R++ + L ++ K ++ +
Sbjct: 2232 ----SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2287
Query: 542 EESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGE-AEEGATSDG 600
+E+ Q+ + Q + + +E T L+ +QQ E A+E A
Sbjct: 2288 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2347
Query: 601 EKKREGVTPWA----SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEE 656
E K + A F++ + ++ +R E E E K++ A +S ++ A E +
Sbjct: 2348 EDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 657 MKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG---GDHQK 713
+ EE + + T ++ + + + + + R+ S D E +A+ + +K
Sbjct: 2406 FRKQAEEIGEKLHR----TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2461
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
+ K + ++ + QE + + Q +E + + E F ++ K
Sbjct: 2462 LQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERF------IEQEK 2513
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGP 833
+KLE+ +D +A + +EE +R+++ ++ Q V
Sbjct: 2514 AKLEQLFQDEVA---------KAQQLREEQ----------QRQQQQMEQERQRLVASMEE 2554
Query: 834 TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK-----ELSESQ 888
+ +++ + V R++ E QQ ++ Q E+ A E + +L E Q
Sbjct: 2555 ARRRQHEAE----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2604
Query: 889 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE-EP 947
H A A ++ A+ + ++ ++ P + E E + + L R+V A+ +
Sbjct: 2605 -HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQE 2660
Query: 948 PTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVS 1007
+ R A+G T V E + + + G A E + +A+
Sbjct: 2661 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA---GLLLKATNEKLSVYAALQ 2717
Query: 1008 QLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ SP T Q G + D R T V E VKE G GPE
Sbjct: 2718 RQLLSPGTALILLEAQAASGFLLDPVRNRRLT------VNEAVKE-----GVVGPE 2762
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 224 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 278
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1374 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1432
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 338
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1433 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1488
Query: 339 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Query: 388 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 445
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1607
Query: 446 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 505
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 506 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 560
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1718
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 617
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1719 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1778
Query: 618 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 673
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1779 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1838
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1839 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1884
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
Q + E E L R ++ L K + + +
Sbjct: 1885 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1944
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1945 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 1978
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 905
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 1979 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2038 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
+A+ +A AAE +E + AE+ +++
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2128
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 1080
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2188
Query: 1081 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1129
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2189 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2246
Query: 1130 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2247 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2294
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1245
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2295 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2341
Query: 1246 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1305
E+S E + + A A+E + R++ E+ K
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2384
Query: 1306 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2443
Query: 1363 AVTVSEEVSKQLLQ 1376
TV +E QLLQ
Sbjct: 2444 MQTVQQE---QLLQ 2454
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 489
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1402
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1447
Query: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 609
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1502
Query: 610 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 669
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1560
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 729
+R + E + V ++ A R + E + + K E +
Sbjct: 1561 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1668
Query: 790 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1669 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 909
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1722 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1781
Query: 910 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 969
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1782 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1838
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1839 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1881
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 1086
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1882 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1938
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1144
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1939 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 1992
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1201
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 1993 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2051
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2107
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2108 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2159
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1376
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2216
Query: 1377 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1427
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2273
Query: 1428 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1484
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2274 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2320
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2321 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2376
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1603
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2377 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
A K + SE+ TV+ E Q L++ L S
Sbjct: 2433 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2465
Query: 1664 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1721
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2466 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2524
Query: 1722 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1772
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2574
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 831 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1027 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1086
Query: 891 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 945
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1087 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1144
Query: 946 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 1002
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1145 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1204
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 1058
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1205 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1261
Query: 1059 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1110
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1262 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1317
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1318 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1372
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1373 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1419
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1290
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1473
Query: 1291 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1350
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1525
Query: 1351 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1410
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1526 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1574
Query: 1411 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1470
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1575 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1626
Query: 1471 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1530
QA++ A + E + + E+++Q +++ A
Sbjct: 1627 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1674
Query: 1531 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1675 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1733
Query: 1589 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1642
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1793
Query: 1643 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1851
Query: 1692 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1742
+ K D K D + E Q + DT + +E +K
Sbjct: 1852 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 1743 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1911 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946
Score = 45.8 bits (107), Expect = 4e-04
Identities = 189/1016 (18%), Positives = 381/1016 (37%), Gaps = 118/1016 (11%)
Query: 91 QGALNSQEEEEVIVTE----VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEII 146
+ A + E E ++ E +G+ + KE ++ + + +D + +
Sbjct: 1790 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1849
Query: 147 EQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDE 205
EQ ++++EE L Q ++ +++ +K G + + + + ++L +K
Sbjct: 1850 EQAAQHKADIEERLAQLRKASDSELERQK-----GLVEDTLRQRRQVEE--EILALKASF 1902
Query: 206 GEGAAGAGD----------HKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
+ AAG + + + +L + E A E+ ++ EE +RE
Sbjct: 1903 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1962
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +A + K EE E+ +K E+ +E S + Q A ++ + K
Sbjct: 1963 AAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE-AAQKRLQAEEK 2020
Query: 316 PKEDEVEASEKKKEQEPEKVDTEED---GKAEVASEKLTASEQAHPQEPAESAHEPRLSA 372
V+ E++ +Q ++ + D G+AE A +E+A Q E+A R
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080
Query: 373 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQK 432
E E+++ +EEQ ++ ++ L E E Q E A + E+ K
Sbjct: 2081 EAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 433 TEVEET--AGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 490
E+T + +EL + + +E + K L+ + + E S E+ L
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2199
Query: 491 KPPEGVVSEVEMLSS-QERMKVQGSPL--------KKLFTSTGLKKLSGKKQKGKRGGGD 541
V ++E LS + R++ + L ++ K ++ +
Sbjct: 2200 ----SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2255
Query: 542 EESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGE-AEEGATSDG 600
+E+ Q+ + Q + + +E T L+ +QQ E A+E A
Sbjct: 2256 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2315
Query: 601 EKKREGVTPWA----SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEE 656
E K + A F++ + ++ +R E E E K++ A +S ++ A E +
Sbjct: 2316 EDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Query: 657 MKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG---GDHQK 713
+ EE + + T ++ + + + + + R+ S D E +A+ + +K
Sbjct: 2374 FRKQAEEIGEKLHR----TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2429
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
+ K + ++ + QE + + Q +E + + E F ++ K
Sbjct: 2430 LQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERF------IEQEK 2481
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGP 833
+KLE+ +D +A + +EE +R+++ ++ Q V
Sbjct: 2482 AKLEQLFQDEVA---------KAQQLREEQ----------QRQQQQMEQERQRLVASMEE 2522
Query: 834 TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK-----ELSESQ 888
+ +++ + V R++ E QQ ++ Q E+ A E + +L E Q
Sbjct: 2523 ARRRQHEAE----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2572
Query: 889 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE-EP 947
H A A ++ A+ + ++ ++ P + E E + + L R+V A+ +
Sbjct: 2573 -HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQE 2628
Query: 948 PTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVS 1007
+ R A+G T V E + + + G A E + +A+
Sbjct: 2629 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA---GLLLKATNEKLSVYAALQ 2685
Query: 1008 QLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ SP T Q G + D R T V E VKE G GPE
Sbjct: 2686 RQLLSPGTALILLEAQAASGFLLDPVRNRRLT------VNEAVKE-----GVVGPE 2730
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 224 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 278
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1543 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1601
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 338
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1602 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1657
Query: 339 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Query: 388 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 445
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1776
Query: 446 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 505
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 506 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 560
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1887
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 617
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947
Query: 618 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 673
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 2008 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 2053
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
Q + E E L R ++ L K + + +
Sbjct: 2054 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 2113
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E + E+ ++K + + +Q +A +E+
Sbjct: 2114 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 2147
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 905
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 2148 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2207 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
+A+ +A AAE +E + AE+ +++
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2297
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 1080
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2357
Query: 1081 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1129
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2358 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2415
Query: 1130 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2416 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2463
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1245
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2464 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2510
Query: 1246 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1305
E+S E + + A A+E + R++ E+ K
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2553
Query: 1306 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2612
Query: 1363 AVTVSEEVSKQLLQ 1376
TV +E QLLQ
Sbjct: 2613 MQTVQQE---QLLQ 2623
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 489
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1571
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1616
Query: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 609
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1671
Query: 610 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 669
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1729
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 729
+R + E + V ++ A R + E + + K E +
Sbjct: 1730 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1837
Query: 790 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1838 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 909
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1891 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1950
Query: 910 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 969
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1951 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 2007
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 2008 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 2050
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 1086
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 2051 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 2107
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1144
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 2108 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2161
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1201
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2220
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2276
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2277 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2328
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1376
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2385
Query: 1377 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1427
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2442
Query: 1428 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1484
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2443 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2489
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2490 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2545
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1603
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2546 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
A K + SE+ TV+ E Q L++ L S
Sbjct: 2602 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2634
Query: 1664 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1721
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2693
Query: 1722 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1772
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2743
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 831 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1196 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1255
Query: 891 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 945
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1256 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1313
Query: 946 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 1002
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 1058
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1374 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1430
Query: 1059 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1110
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1431 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1486
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1487 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1541
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1542 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1588
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1290
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1642
Query: 1291 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1350
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1694
Query: 1351 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1410
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1695 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1743
Query: 1411 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1470
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1744 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1795
Query: 1471 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1530
QA++ A + E + + E+++Q +++ A
Sbjct: 1796 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1843
Query: 1531 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1844 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1902
Query: 1589 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1642
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1962
Query: 1643 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 2020
Query: 1692 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1742
+ K D K D + E Q + DT + +E +K
Sbjct: 2021 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 1743 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 2080 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115
Score = 45.8 bits (107), Expect = 4e-04
Identities = 189/1016 (18%), Positives = 381/1016 (37%), Gaps = 118/1016 (11%)
Query: 91 QGALNSQEEEEVIVTE----VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEII 146
+ A + E E ++ E +G+ + KE ++ + + +D + +
Sbjct: 1959 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 2018
Query: 147 EQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDE 205
EQ ++++EE L Q ++ +++ +K G + + + + ++L +K
Sbjct: 2019 EQAAQHKADIEERLAQLRKASDSELERQK-----GLVEDTLRQRRQVEE--EILALKASF 2071
Query: 206 GEGAAGAGD----------HKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
+ AAG + + + +L + E A E+ ++ EE +RE
Sbjct: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 2131
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +A + K EE E+ +K E+ +E S + Q A ++ + K
Sbjct: 2132 AAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE-AAQKRLQAEEK 2189
Query: 316 PKEDEVEASEKKKEQEPEKVDTEED---GKAEVASEKLTASEQAHPQEPAESAHEPRLSA 372
V+ E++ +Q ++ + D G+AE A +E+A Q E+A R
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249
Query: 373 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQK 432
E E+++ +EEQ ++ ++ L E E Q E A + E+ K
Sbjct: 2250 EAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 433 TEVEET--AGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 490
E+T + +EL + + +E + K L+ + + E S E+ L
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2368
Query: 491 KPPEGVVSEVEMLSS-QERMKVQGSPL--------KKLFTSTGLKKLSGKKQKGKRGGGD 541
V ++E LS + R++ + L ++ K ++ +
Sbjct: 2369 ----SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2424
Query: 542 EESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGE-AEEGATSDG 600
+E+ Q+ + Q + + +E T L+ +QQ E A+E A
Sbjct: 2425 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2484
Query: 601 EKKREGVTPWA----SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEE 656
E K + A F++ + ++ +R E E E K++ A +S ++ A E +
Sbjct: 2485 EDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Query: 657 MKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG---GDHQK 713
+ EE + + T ++ + + + + + R+ S D E +A+ + +K
Sbjct: 2543 FRKQAEEIGEKLHR----TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2598
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
+ K + ++ + QE + + Q +E + + E F ++ K
Sbjct: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERF------IEQEK 2650
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGP 833
+KLE+ +D +A + +EE +R+++ ++ Q V
Sbjct: 2651 AKLEQLFQDEVA---------KAQQLREEQ----------QRQQQQMEQERQRLVASMEE 2691
Query: 834 TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK-----ELSESQ 888
+ +++ + V R++ E QQ ++ Q E+ A E + +L E Q
Sbjct: 2692 ARRRQHEAE----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741
Query: 889 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE-EP 947
H A A ++ A+ + ++ ++ P + E E + + L R+V A+ +
Sbjct: 2742 -HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQE 2797
Query: 948 PTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVS 1007
+ R A+G T V E + + + G A E + +A+
Sbjct: 2798 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA---GLLLKATNEKLSVYAALQ 2854
Query: 1008 QLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ SP T Q G + D R T V E VKE G GPE
Sbjct: 2855 RQLLSPGTALILLEAQAASGFLLDPVRNRRLT------VNEAVKE-----GVVGPE 2899
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 224 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 278
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1384 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1442
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 338
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1443 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1498
Query: 339 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Query: 388 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 445
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1617
Query: 446 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 505
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 506 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 560
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1728
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 617
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1788
Query: 618 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 673
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1789 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1848
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1849 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1894
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
Q + E E L R ++ L K + + +
Sbjct: 1895 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1954
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1955 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 1988
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 905
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 1989 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2048 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
+A+ +A AAE +E + AE+ +++
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2138
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 1080
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2198
Query: 1081 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1129
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2199 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2256
Query: 1130 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2257 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2304
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1245
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2305 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2351
Query: 1246 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1305
E+S E + + A A+E + R++ E+ K
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2394
Query: 1306 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2453
Query: 1363 AVTVSEEVSKQLLQ 1376
TV +E QLLQ
Sbjct: 2454 MQTVQQE---QLLQ 2464
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 489
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1412
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1457
Query: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 609
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1512
Query: 610 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 669
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1513 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1570
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 729
+R + E + V ++ A R + E + + K E +
Sbjct: 1571 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1678
Query: 790 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1679 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 909
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1732 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1791
Query: 910 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 969
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1792 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1848
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1849 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1891
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 1086
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1892 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1948
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1144
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1949 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2002
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1201
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2061
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2117
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2118 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2169
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1376
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2226
Query: 1377 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1427
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2283
Query: 1428 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1484
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2284 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2330
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2331 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2386
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1603
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2387 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
A K + SE+ TV+ E Q L++ L S
Sbjct: 2443 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2475
Query: 1664 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1721
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2534
Query: 1722 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1772
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2584
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 831 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1037 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1096
Query: 891 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 945
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1097 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1154
Query: 946 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 1002
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 1058
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1215 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1271
Query: 1059 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1110
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1272 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1327
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1328 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1382
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1383 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1429
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1290
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1483
Query: 1291 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1350
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1535
Query: 1351 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1410
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1536 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1584
Query: 1411 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1470
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1585 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1636
Query: 1471 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1530
QA++ A + E + + E+++Q +++ A
Sbjct: 1637 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1684
Query: 1531 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1685 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1743
Query: 1589 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1642
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1744 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1803
Query: 1643 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1861
Query: 1692 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1742
+ K D K D + E Q + DT + +E +K
Sbjct: 1862 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 1743 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Score = 45.8 bits (107), Expect = 4e-04
Identities = 189/1016 (18%), Positives = 381/1016 (37%), Gaps = 118/1016 (11%)
Query: 91 QGALNSQEEEEVIVTE----VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEII 146
+ A + E E ++ E +G+ + KE ++ + + +D + +
Sbjct: 1800 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1859
Query: 147 EQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDE 205
EQ ++++EE L Q ++ +++ +K G + + + + ++L +K
Sbjct: 1860 EQAAQHKADIEERLAQLRKASDSELERQK-----GLVEDTLRQRRQVEE--EILALKASF 1912
Query: 206 GEGAAGAGD----------HKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
+ AAG + + + +L + E A E+ ++ EE +RE
Sbjct: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1972
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +A + K EE E+ +K E+ +E S + Q A ++ + K
Sbjct: 1973 AAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE-AAQKRLQAEEK 2030
Query: 316 PKEDEVEASEKKKEQEPEKVDTEED---GKAEVASEKLTASEQAHPQEPAESAHEPRLSA 372
V+ E++ +Q ++ + D G+AE A +E+A Q E+A R
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090
Query: 373 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQK 432
E E+++ +EEQ ++ ++ L E E Q E A + E+ K
Sbjct: 2091 EAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149
Query: 433 TEVEET--AGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 490
E+T + +EL + + +E + K L+ + + E S E+ L
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2209
Query: 491 KPPEGVVSEVEMLSS-QERMKVQGSPL--------KKLFTSTGLKKLSGKKQKGKRGGGD 541
V ++E LS + R++ + L ++ K ++ +
Sbjct: 2210 ----SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2265
Query: 542 EESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGE-AEEGATSDG 600
+E+ Q+ + Q + + +E T L+ +QQ E A+E A
Sbjct: 2266 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2325
Query: 601 EKKREGVTPWA----SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEE 656
E K + A F++ + ++ +R E E E K++ A +S ++ A E +
Sbjct: 2326 EDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Query: 657 MKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG---GDHQK 713
+ EE + + T ++ + + + + + R+ S D E +A+ + +K
Sbjct: 2384 FRKQAEEIGEKLHR----TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2439
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
+ K + ++ + QE + + Q +E + + E F ++ K
Sbjct: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERF------IEQEK 2491
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGP 833
+KLE+ +D +A + +EE +R+++ ++ Q V
Sbjct: 2492 AKLEQLFQDEVA---------KAQQLREEQ----------QRQQQQMEQERQRLVASMEE 2532
Query: 834 TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK-----ELSESQ 888
+ +++ + V R++ E QQ ++ Q E+ A E + +L E Q
Sbjct: 2533 ARRRQHEAE----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
Query: 889 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE-EP 947
H A A ++ A+ + ++ ++ P + E E + + L R+V A+ +
Sbjct: 2583 -HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQE 2638
Query: 948 PTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVS 1007
+ R A+G T V E + + + G A E + +A+
Sbjct: 2639 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA---GLLLKATNEKLSVYAALQ 2695
Query: 1008 QLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ SP T Q G + D R T V E VKE G GPE
Sbjct: 2696 RQLLSPGTALILLEAQAASGFLLDPVRNRRLT------VNEAVKE-----GVVGPE 2740
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 73.6 bits (179), Expect = 2e-12
Identities = 228/1214 (18%), Positives = 451/1214 (37%), Gaps = 194/1214 (15%)
Query: 224 EAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEE-----KQEKEPS 278
EAA + K+S ++ + L R+ S AEI A +A E + EE + + E +
Sbjct: 1392 EAAVDAQQQKRSIQEELQQL-RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEAT 1450
Query: 279 KSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTE 338
+ + ++ Q + R+ +DE S++K++ E E + +
Sbjct: 1451 ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEVE-LASR 1506
Query: 339 EDGKAEVASEK-----------LTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSG 387
+AE A EK L A E AE ++ E + +E ++
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Query: 388 SQGPSEEKPAPLATEVFDEKIEVHQ--EEVVAEVHVSTVEERTEEQKTEVEETAGSVPAE 445
+ EK A L + +E + V Q EE ER E+ E E + A
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-AERELERWQLKAN 1625
Query: 446 ELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSS 505
E + + + +E K L + E Q + + + K E V + E+
Sbjct: 1626 EALRLRLQAEEVAQQKSLAQ-------AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 506 Q---ERMKVQGSPLKKLFTSTGLKKLSGKKQKG--KRGGGDEESGEHTQVPADSPDSQEE 560
+ +R +G+ ++L L +L + ++G +R +EE + A + +Q+
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAA--TQKR 1736
Query: 561 QKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEG---ATSDGEKKREGVTPWASFKKMV 617
Q+ E+ + E+ K AE + +E+ ++ + RE A + +
Sbjct: 1737 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1796
Query: 618 TPKKRVRRPSESD---KEDELDKVKSATLSST-ESTASEMQEEMKGSVEEPKPEEPKRKV 673
KR R+ +E D + E ++V + L++ E+T + + E+ +E + E +R
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1856
Query: 674 DTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQ 733
+ + ++R ++ + + +KA ++ +++ G L
Sbjct: 1857 EDE----------AFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG----LVEDT 1902
Query: 734 EHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHST 793
Q + E E L R ++ L K + + +
Sbjct: 1903 LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLA 1962
Query: 794 PDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYD 853
+ E + E+ ++K + + +Q +A +E+
Sbjct: 1963 AEEERRRREAEERVQKSLAAEEEA---ARQRKAALEE----------------------- 1996
Query: 854 AVEREKMEAQQAQKSAEQPEQKAATEV-------SKEL-SESQVHMMAAAVADGTRAATI 905
VER K + ++A++ E+ EQ++A ++ K L +E + H A + T+
Sbjct: 1997 -VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 906 IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTV 965
+E+ SV + L + EAEAA E E + E + E E +
Sbjct: 2056 QQEQ-------SVLDQL-RGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 966 VSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV 1025
+A+ +A AAE +E + AE+ +++
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA---------------------LRQK 2146
Query: 1026 EGGVPDIEEQERRTQEVLQAVAEKVKE----ESQLPGTGGPEDVL-QPVQRAEAERPEEQ 1080
+ ++E+ ++ ++ L+ A+ +E QL T +++L + +QR +AE E
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2206
Query: 1081 AEASGLKKETDVVLKVDAQE-----AKTEPFTQGKVV------GQTTPESFEKAPQVTES 1129
+ S +++E V +V +E A+ E + ++ + E EK QV E
Sbjct: 2207 RQRSQVEEELFSV-RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE- 2264
Query: 1130 IESSEL-VTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQK 1188
E++ L V +A L + +++ ++A+ ++ + + T K
Sbjct: 2265 -EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-----------ATRLK 2312
Query: 1189 DEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLE---H 1245
E + ++ E+A +A + KE+ + Q+ +E + TLE
Sbjct: 2313 AEAELLQQQKELAQ------EQARRLQEDKEQ-------MAQQLAEETQGFQRTLEAERQ 2359
Query: 1246 TDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALK 1305
E+S E + + A A+E + R++ E+ K
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF-----------------RKQAEEIGEK 2402
Query: 1306 GEGTEEAECKK---DDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHET 1362
TE A +K LE+Q + RE + ++EREK + + +L+ E
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ-QEAKLLQLKSEE 2461
Query: 1363 AVTVSEEVSKQLLQ 1376
TV +E QLLQ
Sbjct: 2462 MQTVQQE---QLLQ 2472
Score = 68.6 bits (166), Expect = 5e-11
Identities = 263/1431 (18%), Positives = 535/1431 (37%), Gaps = 181/1431 (12%)
Query: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
L+++Y K + ++ + +E++ A + + + + ++ +AE H +
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVL 489
E K + V E +DA+ Q+ +EL +L++ S + ++
Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ--------------SSEAEIQ 1420
Query: 490 SKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ 549
+K + +E L +E ++V +L + + +RGG + E + +
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRV--------------VRLQLEATERQRGGAEGEL-QALR 1465
Query: 550 VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTP 609
A+ ++Q+ Q E + + ++ K AEV+ + A + EK+R
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAREKQR----A 1520
Query: 610 WASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEP 669
+ +++ + R + + +V+ A ++ S +E+Q + E K +
Sbjct: 1521 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE--KTAQL 1578
Query: 670 KRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL 729
+R + E + V ++ A R + E + + K E +
Sbjct: 1579 ERSLQ-----EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 730 AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGV 789
A + E+ E E ++ ++ V R+ ++ +LE++ + +
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ-------L 1686
Query: 790 EHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPL 849
T E+ + + R + G+Q++ +E+ E + L
Sbjct: 1687 AEGTAQQRLAAEQELIRL-------RAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 850 SEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER 909
A R +ME A K+ + E ++ +E SK+ E++ + R + EE
Sbjct: 1740 EAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1799
Query: 910 SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA 969
A ++ EAE L + E + T E + +EA + + A
Sbjct: 1800 KRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK---TEAEIALKEKEAENERLRRLA 1856
Query: 970 ELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGV 1029
E EA E AA+ ++ ++QL + D + ++ +G V
Sbjct: 1857 E--DEAF----------QRRRLEEQAAQHKADIEERLAQLRKASD-----SELERQKGLV 1899
Query: 1030 PDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAE---RPEEQAEASGL 1086
D Q R+ +E + +A K E G E L + R+ AE R +EQAE
Sbjct: 1900 EDTLRQRRQVEE--EILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAA 1956
Query: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTC--QAETL 1144
++ ++ A+E + + +V E E A Q ++E E + +A L
Sbjct: 1957 RQR-----QLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRL 2010
Query: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDG---STPVADFDAPGTTQKDEIVEIHEENEVA 1201
QE + + ++ + +E + + + T Q+++ V + + A
Sbjct: 2011 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSV-LDQLRGEA 2069
Query: 1202 SGTQSGGTEAEAVPAQKERPPAPSSFVFQE-ETKEQSKMEDTLEHTDKEVSVETVSILSK 1260
+ EAE Q ER A S +E E +QS E + + E + +
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL----R 2125
Query: 1261 TEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDAL 1320
E QEA + A + + + + ++ +K E L+ + E E L
Sbjct: 2126 KEAEQEAARRAQAEQAALRQKQAADAEME-----KHKKFAEQTLRQKAQVEQEL---TTL 2177
Query: 1321 ELQSHAKSPPSPVEREMVVQVEREKTEA--EPTHVNEEKLEHETAVTVSEEVS--KQLLQ 1376
LQ + E + +++ E TEA + + V EE + EE+S K ++
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQM---EELSKLKARIE 2234
Query: 1377 TVNVPII----DGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEE----- 1427
N +I D + E + +E A ++ V + EA+ A E+
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAA---RLSVAAQEAARLRQLAEEDLAQQR 2291
Query: 1428 ---EKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKST 1484
EK+L E ++ L+ A A L+ ++K E ++ A ED K
Sbjct: 2292 ALAEKMLKEKMQAVQEATRLK-AEAELLQQQK--ELAQEQARRLQED----------KEQ 2338
Query: 1485 PVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELET 1544
A +G LE E+ L+ ++ E++ + ++S A E
Sbjct: 2339 MAQQLAEETQGFQRTLEAERQRQLEMSAEA--ERLKLRVAEMSRA--QARAEEDAQRFRK 2394
Query: 1545 KSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADS-QDAGQETEKEGEEPQA 1603
++ ++ + + +T + T+E T + T E+Q Q A+ ++A E E+E E+ Q
Sbjct: 2395 QAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450
Query: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
A K + SE+ TV+ E Q L++ L S
Sbjct: 2451 EA--------------------------KLLQLKSEEMQTVQQEQLLQETQALQQSFL-S 2483
Query: 1664 EEEGGGAGTKSVPEDDG--HALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASG 1721
E++ + + ++ L + + K+ +E ++ + E Q +A + +
Sbjct: 2484 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR-LVASMEEAR 2542
Query: 1722 GLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQER 1772
E+ + KQ+E + ++ Q+ ++ +E ++ + Q Q L++Q R
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHR 2592
Score = 52.4 bits (124), Expect = 4e-06
Identities = 179/996 (17%), Positives = 359/996 (36%), Gaps = 124/996 (12%)
Query: 831 AGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVH 890
A PT +E + + + + A+ EK++ Q ++ ++L E+Q
Sbjct: 1045 AAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1104
Query: 891 MMAAAVADGTRAA-----TIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE 945
+ T+A+ E + P++ ++ + L + L + ER+V E
Sbjct: 1105 PATLPELEATKASLKKLRAQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVER 1162
Query: 946 EPPTVTEPLPENREARGDTVVSEAELTP---EAVTAAETAGPLGAEEGTEASAAEETTEM 1002
V + L + T V + EL + E+A PLGA E+ M
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222
Query: 1003 VSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEK----VKEESQLPG 1058
A SQ E+A ++E+E +EE +R ++ + A+ + V ++QL
Sbjct: 1223 PLADSQAVREQLRQEQAL-LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1279
Query: 1059 TGGPEDVLQPVQRAEAERPEEQA--EASGLKKETDVVLKVDAQEAKTEPFT------QGK 1110
E V P ++ + + E E L+ + + +Q K T + +
Sbjct: 1280 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1335
Query: 1111 VVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSE 1170
+ Q E E+ +V ++E + A+ A + + ++Q + + V
Sbjct: 1336 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR----- 1390
Query: 1171 TDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQ 1230
D + ++E+ ++ + +E Q+ +AEA + R +
Sbjct: 1391 ---EEAAVDAQQQKRSIQEELQQLRQSSEAE--IQAKARQAEAAERSRLR--------IE 1437
Query: 1231 EETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDT 1290
EE + + E E ++ ++ E + + A E+ E L +
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEA------ERLRRQVQD 1491
Query: 1291 GITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEP 1350
R+ E+A + + EA +K AL+ R + ER +AE
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL--------RLQAEEAERRLRQAEV 1543
Query: 1351 THVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKI 1410
+ ++ ETA +E LQ+ A++ + LE S L +E ++
Sbjct: 1544 ERARQVQVALETAQRSAEAE----LQSKRASF---AEKTAQLERS----LQEEHVAVAQL 1592
Query: 1411 QVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGE 1470
+ EA AE E+ E LE + L L+ + + + A
Sbjct: 1593 R---EEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA----- 1644
Query: 1471 DAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAI 1530
QA++ A + E + + E+++Q +++ A
Sbjct: 1645 ---------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ---RQLAEGTAQ 1692
Query: 1531 EDLEPENGILEL--ETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQ 1588
+ L E ++ L ET+ + + +++ + + R AT+ EL+ + ++A+ +
Sbjct: 1693 QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK-RQELEAELAKVRAEME 1751
Query: 1589 -----DAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSE-ASEKTM 1642
A E E ++ + E +E +E A +A ++ +K + A E
Sbjct: 1752 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1811
Query: 1643 TVEVEGSTVNDQQL-----------EEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKS 1691
E V ++L E + E+E + + ED+ A R+E+
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDE--AFQRRRLEEQ 1869
Query: 1692 LVEPKED--------EKGDDVDDPENQNSALADT-DASGGLTKESPDTNGPKQKEKEDAQ 1742
+ K D K D + E Q + DT + +E +K
Sbjct: 1870 AAQHKADIEERLAQLRKASD-SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 1743 EVELQEGKVHSESDKAITPQAQEELQKQERESAKSE 1778
E+EL+ G++ S ++ + + Q EL+ + +E
Sbjct: 1929 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964
Score = 45.8 bits (107), Expect = 4e-04
Identities = 189/1016 (18%), Positives = 381/1016 (37%), Gaps = 118/1016 (11%)
Query: 91 QGALNSQEEEEVIVTE----VGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEII 146
+ A + E E ++ E +G+ + KE ++ + + +D + +
Sbjct: 1808 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE 1867
Query: 147 EQIPSSESNLEE-LTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDE 205
EQ ++++EE L Q ++ +++ +K G + + + + ++L +K
Sbjct: 1868 EQAAQHKADIEERLAQLRKASDSELERQK-----GLVEDTLRQRRQVEE--EILALKASF 1920
Query: 206 GEGAAGAGD----------HKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPP 255
+ AAG + + + +L + E A E+ ++ EE +RE
Sbjct: 1921 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL 1980
Query: 256 AESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRK 315
A +A + K EE E+ +K E+ +E S + Q A ++ + K
Sbjct: 1981 AAEEEAARQRKAALEEV-ERLKAKVEEARRLRERAEQESARQLQLAQE-AAQKRLQAEEK 2038
Query: 316 PKEDEVEASEKKKEQEPEKVDTEED---GKAEVASEKLTASEQAHPQEPAESAHEPRLSA 372
V+ E++ +Q ++ + D G+AE A +E+A Q E+A R
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098
Query: 373 EYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQK 432
E E+++ +EEQ ++ ++ L E E Q E A + E+ K
Sbjct: 2099 EAERLKQSAEEQAQ-ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2157
Query: 433 TEVEET--AGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLS 490
E+T + +EL + + +E + K L+ + + E S E+ L
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2217
Query: 491 KPPEGVVSEVEMLSS-QERMKVQGSPL--------KKLFTSTGLKKLSGKKQKGKRGGGD 541
V ++E LS + R++ + L ++ K ++ +
Sbjct: 2218 ----SVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA 2273
Query: 542 EESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGE-AEEGATSDG 600
+E+ Q+ + Q + + +E T L+ +QQ E A+E A
Sbjct: 2274 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2333
Query: 601 EKKREGVTPWA----SFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEE 656
E K + A F++ + ++ +R E E E K++ A +S ++ A E +
Sbjct: 2334 EDKEQMAQQLAEETQGFQRTLEAER--QRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Query: 657 MKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMG---GDHQK 713
+ EE + + T ++ + + + + + R+ S D E +A+ + +K
Sbjct: 2392 FRKQAEEIGEKLHR----TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2447
Query: 714 ADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSK 773
+ K + ++ + QE + + Q +E + + E F ++ K
Sbjct: 2448 LQQEAKLLQLKSEEMQTVQQEQLLQE--TQALQQSFLSEKDSLLQRERF------IEQEK 2499
Query: 774 SKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGP 833
+KLE+ +D +A + +EE +R+++ ++ Q V
Sbjct: 2500 AKLEQLFQDEVA---------KAQQLREEQ----------QRQQQQMEQERQRLVASMEE 2540
Query: 834 TGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSK-----ELSESQ 888
+ +++ + V R++ E QQ ++ Q E+ A E + +L E Q
Sbjct: 2541 ARRRQHEAE----------EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2590
Query: 889 VHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEE-EP 947
H A A ++ A+ + ++ ++ P + E E + + L R+V A+ +
Sbjct: 2591 -HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSF---DGLRRKVSAQRLQE 2646
Query: 948 PTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVS 1007
+ R A+G T V E + + + G A E + +A+
Sbjct: 2647 AGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIA---GLLLKATNEKLSVYAALQ 2703
Query: 1008 QLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPE 1063
+ SP T Q G + D R T V E VKE G GPE
Sbjct: 2704 RQLLSPGTALILLEAQAASGFLLDPVRNRRLT------VNEAVKE-----GVVGPE 2748
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.298 0.119 0.311
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,480,128
Number of Sequences: 37866
Number of extensions: 4046239
Number of successful extensions: 29757
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 1501
Number of HSP's that attempted gapping in prelim test: 16054
Number of HSP's gapped (non-prelim): 10165
length of query: 1782
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1665
effective length of database: 13,817,196
effective search space: 23005631340
effective search space used: 23005631340
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.