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Search of human proteins with 214010165
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo
sapiens]
(460 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo ... 898 0.0
gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo sa... 888 0.0
gi|28195388 RAB11 family interacting protein 4 (class II) [Homo ... 336 2e-92
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 77 4e-14
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 74 3e-13
gi|55770834 centromere protein F [Homo sapiens] 73 6e-13
gi|237858621 polyamine modulated factor 1 binding protein 1 isof... 71 2e-12
gi|237858619 polyamine modulated factor 1 binding protein 1 isof... 71 2e-12
gi|110347443 TATA element modulatory factor 1 [Homo sapiens] 70 5e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 69 9e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 68 2e-11
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 68 2e-11
gi|34577114 cytomatrix protein p110 [Homo sapiens] 68 2e-11
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 67 3e-11
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 67 3e-11
gi|148746195 trichohyalin [Homo sapiens] 67 4e-11
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 66 8e-11
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 65 1e-10
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 65 2e-10
gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 64 2e-10
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 64 2e-10
gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo sap... 64 3e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 3e-10
gi|42794779 myosin 18A isoform b [Homo sapiens] 64 3e-10
gi|28416946 myosin 18A isoform a [Homo sapiens] 64 3e-10
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 64 4e-10
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 63 5e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 63 5e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 63 5e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 63 5e-10
>gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo
sapiens]
Length = 460
Score = 898 bits (2321), Expect = 0.0
Identities = 460/460 (100%), Positives = 460/460 (100%)
Query: 1 MPFLKANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLD 60
MPFLKANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLD
Sbjct: 1 MPFLKANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLD 60
Query: 61 AMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDP 120
AMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDP
Sbjct: 61 AMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDP 120
Query: 121 AFLTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLEL 180
AFLTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLEL
Sbjct: 121 AFLTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLEL 180
Query: 181 EKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMERE 240
EKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMERE
Sbjct: 181 EKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMERE 240
Query: 241 KSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQEN 300
KSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQEN
Sbjct: 241 KSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQEN 300
Query: 301 KRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHS 360
KRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHS
Sbjct: 301 KRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHS 360
Query: 361 RARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVS 420
RARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVS
Sbjct: 361 RARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVS 420
Query: 421 RDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 460
RDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK
Sbjct: 421 RDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 460
>gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo
sapiens]
Length = 756
Score = 888 bits (2295), Expect = 0.0
Identities = 455/456 (99%), Positives = 456/456 (100%)
Query: 5 KANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEE 64
+ANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEE
Sbjct: 301 EANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEE 360
Query: 65 PDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLT 124
PDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLT
Sbjct: 361 PDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLT 420
Query: 125 PSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDT 184
PSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDT
Sbjct: 421 PSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDT 480
Query: 185 AATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIE 244
AATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIE
Sbjct: 481 AATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIE 540
Query: 245 IENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRM 304
IENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRM
Sbjct: 541 IENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRM 600
Query: 305 GDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARE 364
GDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARE
Sbjct: 601 GDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARE 660
Query: 365 SELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDEL 424
SELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDEL
Sbjct: 661 SELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDEL 720
Query: 425 MEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 460
MEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK
Sbjct: 721 MEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 756
>gi|28195388 RAB11 family interacting protein 4 (class II) [Homo
sapiens]
Length = 637
Score = 336 bits (862), Expect = 2e-92
Identities = 217/534 (40%), Positives = 309/534 (57%), Gaps = 79/534 (14%)
Query: 6 ANEVTDSAYMGSE---STYSECETFT---------DEDTSTLVHPELQPEGDADSAGGSA 53
A E+ D GSE T+++ E +E+ TL PE E DS S
Sbjct: 103 APEIPDCVEQGSEVTGPTFADGELIPREPGFFPEDEEEAMTLAPPEGPQELYTDSPMEST 162
Query: 54 VPSE-CLDAMEEPDHG--ALLLLPGRPHPHGQSVIT----------VIGGEEHFEDYGEG 100
E + + E D G L L + H S+ T +I EE FEDYGEG
Sbjct: 163 QSLEGSVGSPAEKDGGLGGLFLPEDKSLVHTPSMTTSDLSTHSTTSLISNEEQFEDYGEG 222
Query: 101 SEAELSPETLCN---------GQLGCS--DPAFLTP------------------------ 125
+ + +P + C LG S A TP
Sbjct: 223 DDVDCAPSSPCPDDETRTNVYSDLGSSVSSSAGQTPRKMRHVYNSELLDVYCSQCCKKIN 282
Query: 126 ---------------SPTKRLSSKKVARYLHQSGALTME--ALEDPSPELMEGPEEDIAD 168
SP +++SS R L S + + ED + ++ + DI +
Sbjct: 283 LLNDLEARLKNLKANSPNRKISSTAFGRQLMHSSNFSSSNGSTEDLFRDSIDSCDNDITE 342
Query: 169 KVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETR 228
KV FLE++V ELE D+ G+ S+L+QEN QLVHR + LEE +K+QE A + + EE R
Sbjct: 343 KVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQETTAEQALEEEAR 402
Query: 229 RQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIE 288
R +E K+EREK+ E+E L R+QQL+EEN+ELR+ LK+ E+L+EE+Q++ D +E
Sbjct: 403 RHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQRMSDRLE 462
Query: 289 SLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQ-RR 347
+LRL +E + +RM D+L R +FQ+++EATQELIEDLRK+LEHLQ+ KL+ E+ R
Sbjct: 463 DTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPGR 522
Query: 348 GRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFST- 406
GRS+S GL E+++RARE ELE EV+RLKQ+N L++QN++LNGQI++LS+ AK+LF+
Sbjct: 523 GRSASSGLGEFNARAREVELEHEVKRLKQENYKLRDQNDDLNGQILSLSLYEAKNLFAAQ 582
Query: 407 AFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 460
++SLAAEI + SRDELMEA+++QEEINFRL+ Y+D+II+AI++ NPSILE+K
Sbjct: 583 TKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMDKIILAILDHNPSILEIK 636
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 76.6 bits (187), Expect = 4e-14
Identities = 75/258 (29%), Positives = 114/258 (44%), Gaps = 18/258 (6%)
Query: 134 KKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSR 193
+K+ R L + T E L +PE GP KV L+ L K+ + G Q
Sbjct: 131 QKLGRSLFKLKNQTAEPL---APEPPAGPS-----KVEQLQDETNHLRKELESVGRQLQA 182
Query: 194 LRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQ 253
+ N L EE+L+EQE R E E R Q+E LC+ E + E L+ + +
Sbjct: 183 EVENNQMLSLLNRRQEERLREQEERLREQE-ERLREQEERLCEQEERLREQEERLREQEE 241
Query: 254 QLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESL---TLRLSEEQENKRRMGDRLSH 310
+L E+ LR L ERL E++++L ++ E L RL E++E R +RL
Sbjct: 242 RLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCE 301
Query: 311 ERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQE 370
+ + + +E E E LR+Q E L EQ + L+E + ++E
Sbjct: 302 QEERLREQEERLCEQEERLREQEERL------CEQEKLPGQERLLEEVEKLLEQERRQEE 355
Query: 371 VRRLKQDNRNLKEQNEEL 388
RL + R L+E E L
Sbjct: 356 QERLLERERLLEEVEELL 373
Score = 66.6 bits (161), Expect = 4e-11
Identities = 67/224 (29%), Positives = 106/224 (47%), Gaps = 25/224 (11%)
Query: 173 LERRVLE-LEKDTAATGEQHSRLRQENLQLVHRANAL---EEQLKEQELRACEMVLEETR 228
L RR E L + EQ RLR++ +L + L EE+L+EQE R CE EE
Sbjct: 193 LNRRQEERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEERLCEQ--EERL 250
Query: 229 R--------QKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK 280
R Q+E LC+ E + E L + ++L E+ LR L ERL E++
Sbjct: 251 REHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQE 310
Query: 281 QKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLK 340
++L ++ E L EQE + ++L + +R E ++L+E R+Q E +LL+
Sbjct: 311 ERLCEQEERL-----REQEERLCEQEKLPGQ----ERLLEEVEKLLEQERRQEEQERLLE 361
Query: 341 LE--AEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLK 382
E E+ L++ R + E QE+ RL++ R L+
Sbjct: 362 RERLLEEVEELLEQERLRQQDERLWQQETLQELERLRELERMLE 405
Score = 59.3 bits (142), Expect = 7e-09
Identities = 56/213 (26%), Positives = 95/213 (44%), Gaps = 17/213 (7%)
Query: 221 EMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK 280
E + +ET ++ L + R+ E+EN Q + LR L+ ERL E++
Sbjct: 160 EQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERLREQEERLREQE 219
Query: 281 QKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLK 340
++L ++ E RL E++E R +RL Q +R +E + L E + E + L+
Sbjct: 220 ERLCEQEE----RLREQEERLREQEERLC---EQEERLREHEERLCEQEERLCEQEERLR 272
Query: 341 LEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGA 400
+ E+ + + QE R +E L ++ RL++ L EQ E L Q L Q
Sbjct: 273 EQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERLCEQE- 331
Query: 401 KSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
E L E+ ++L+E ++QEE
Sbjct: 332 ----KLPGQERLLEEV-----EKLLEQERRQEE 355
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 73.9 bits (180), Expect = 3e-13
Identities = 77/281 (27%), Positives = 134/281 (47%), Gaps = 27/281 (9%)
Query: 192 SRLRQE--NLQLVHRANALE--EQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIEN 247
+R +QE L+ +H A L+ E+ ++ LR E + E+ R+KE L + ERE++ + +
Sbjct: 717 ARHKQEVRRLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQR 776
Query: 248 --LQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKR-RM 304
L+ QQL+E +S L T L+A E+ EE+++ ++E TL+ E E +
Sbjct: 777 AELEELRQQLEESSSAL---TRALRAEFEKGREEQERR-HQMELNTLKQQLELERQAWEA 832
Query: 305 GDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARE 364
G E R++E +E+ + K++E L + +LEA+ + S E +
Sbjct: 833 GRTRKEEAWLLNREQELREEIRKGRDKEIE-LVIHRLEADMALAKEESEKAAESRIKRLR 891
Query: 365 SELEQEVRRLKQDNRNLKEQNEELNGQI-----ITLSIQGAKSLFSTAFSESLAA-EISS 418
+ E E+ L+Q R L+E+ EL GQ+ L +QG A ++ A E S
Sbjct: 892 DKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS 951
Query: 419 VSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEV 459
R L + I+ Q++ DR+ + ET + E+
Sbjct: 952 SERSNLAQVIR---------QEFEDRLAASEEETRQAKAEL 983
Score = 42.0 bits (97), Expect = 0.001
Identities = 81/358 (22%), Positives = 141/358 (39%), Gaps = 73/358 (20%)
Query: 156 PELMEGPEEDIADKVVFLERRVLELE------------------------KDT-AATGEQ 190
PE GP E ++ + R LE+E K+T A Q
Sbjct: 553 PEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQ 612
Query: 191 HSRLRQENLQLVHRANALEEQLKEQE---LRACEMVL----EETRRQKELLCKMEREKSI 243
R R+ + R A +QL E + CE V+ +E +R E + + + + +
Sbjct: 613 LQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHEL 672
Query: 244 EIENLQTRLQQLDEENSE--LRSCTPCLK-ANIERLEEEKQKLLDEIESLTLRLSEEQEN 300
EI+ L+ + ++ E + T +K + LE E QKL+ + RL E
Sbjct: 673 EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEA 732
Query: 301 KRRMGDRLSHE---------RHQFQRDKEATQEL------------IEDLRKQLEH---- 335
+ D + + R Q +R+KEA + +E+LR+QLE
Sbjct: 733 ELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQQLEESSSA 792
Query: 336 -LQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQ---EVRRLKQDNRNLKEQNEELNGQ 391
+ L+ E E+ R E ++ ++ ELE+ E R +++ L + +EL +
Sbjct: 793 LTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLNREQELREE 852
Query: 392 I-------ITLSIQGAKSLFSTAFSESLAAEISSVS--RDELMEAIQKQEEINFRLQD 440
I I L I ++ + A ES A S + RD+ + + E+ +LQ+
Sbjct: 853 IRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSERKLQE 910
Score = 34.3 bits (77), Expect = 0.24
Identities = 44/160 (27%), Positives = 67/160 (41%), Gaps = 20/160 (12%)
Query: 126 SPTKRLSSKKVARY--LHQSGALTMEALEDPSPELMEGPEEDIA-DKVVFLERRVLELEK 182
S KRL K A L QS E + +L E E++ +V + R LE
Sbjct: 885 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALE--- 941
Query: 183 DTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKS 242
D A EQ S R Q++ + E++L E EETR+ K L ++ +
Sbjct: 942 DAQAVNEQLSSERSNLAQVIRQE--FEDRLAASE--------EETRQAKAELATLQARQQ 991
Query: 243 IEIE----NLQTRLQQLDEENSELRSCTPCLKANIERLEE 278
+E+E ++T L + +E S LR+ + LEE
Sbjct: 992 LELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEE 1031
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 72.8 bits (177), Expect = 6e-13
Identities = 88/337 (26%), Positives = 165/337 (48%), Gaps = 40/337 (11%)
Query: 142 QSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQL 201
Q+ L +E + +++ EE+++ VV ER L E DT + ++ + L Q + ++
Sbjct: 1929 QTEKLCLEKDNENKQKVIVCLEEELS--VVTSERNQLRGELDTMS--KKTTALDQLSEKM 1984
Query: 202 VHRANALEEQLKEQELRACEMVLE-ETRRQKELLCKMEREKSIEIEN---LQTRLQQLDE 257
+ LE + E C V E E + + ELL + + S +++ LQ +LQ L E
Sbjct: 1985 KEKTQELESH--QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSL-E 2041
Query: 258 ENSELRSCTPC-LKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSH---ERH 313
++S+ S T C L+ I +L +EK+ L+ E ESL RLSE K + L E+
Sbjct: 2042 KDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKG 2101
Query: 314 QFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRR 373
+F +TQE + LR+ +E L+ +++EA++++ + H + E E+E
Sbjct: 2102 EFALRLSSTQEEVHQLRRGIEKLR-VRIEADEKK---------QLHIAEKLKERERENDS 2151
Query: 374 LKQDNRNLKE--QNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRD------ELM 425
LK NL+ Q E N +++ L + +K A E+L +I ++R +L+
Sbjct: 2152 LKDKVENLERELQMSEENQELVILDAENSK-----AEVETLKTQIEEMARSLKVFELDLV 2206
Query: 426 EAIQKQEEINFRLQDYIDRI--IVAIMETNPSILEVK 460
++E + ++Q+ ++ + ++ + S+LE K
Sbjct: 2207 TLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEK 2243
Score = 53.1 bits (126), Expect = 5e-07
Identities = 75/293 (25%), Positives = 116/293 (39%), Gaps = 31/293 (10%)
Query: 157 ELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLV----HRANALEEQL 212
E E + IA+K+ ER L KD E+ ++ +EN +LV + A E L
Sbjct: 2129 EADEKKQLHIAEKLKERERENDSL-KDKVENLERELQMSEENQELVILDAENSKAEVETL 2187
Query: 213 KEQ------ELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCT 266
K Q L+ E+ L R +KE L K +EK ++ L L E
Sbjct: 2188 KTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAE 2247
Query: 267 PCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLS---HERHQFQRDKEATQ 323
+K + E Q L E+ L +QE + L E HQ + E +
Sbjct: 2248 IQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLR 2307
Query: 324 ELIE-DLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLK 382
+E D +KQL LQ LK S R E E E+ R Q++ L+
Sbjct: 2308 ARLEADEKKQLCVLQQLK---------ESEHHADLLKGRVENLERELEIARTNQEHAALE 2358
Query: 383 EQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSV--SRDELMEAIQKQEE 433
+N + G++ TL AK T L ++ ++ ++ L +QK++E
Sbjct: 2359 AENSK--GEVETLK---AKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQE 2406
Score = 52.0 bits (123), Expect = 1e-06
Identities = 70/300 (23%), Positives = 139/300 (46%), Gaps = 42/300 (14%)
Query: 175 RRVLELEKDTAA----TGEQHSRLRQENLQLVHRANALE-EQLKEQELRACEMVLEETRR 229
+R+ +L++DT+A E S L + +L + +E EQ + QEL+ +LE++ +
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Query: 230 QKELLCK---MEREKSIEIENLQTR-LQQLDEENSELRSCTPCLKANIERLEEEKQKLLD 285
+ +LL + +E+++ I +L R +++L +EN L+ L +EK L+
Sbjct: 943 ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLN-------QEKMNLIQ 995
Query: 286 EIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQ 345
+ ES + E +++ + D+ E+ + E T EDL + K +A Q
Sbjct: 996 KSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQ--------KYKAAQ 1047
Query: 346 RRGRSSSMGLQEYHS--RARESELEQEVRRLKQDNRNL-------KEQNEELNGQIITLS 396
+ L E S R++ELEQ ++++ +E+N+ L ++ T
Sbjct: 1048 EKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELET-- 1105
Query: 397 IQGAKSLFSTAFSESLAAEISSVSRDELM----EAIQKQEEINFRLQDYIDRIIVAIMET 452
+Q A T + +E + + E+M E + Q+E+N LQ+ + ++ +M+T
Sbjct: 1106 VQQALRSEMTDNQNNSKSEAGGL-KQEIMTLKEEQNKMQKEVNDLLQE--NEQLMKVMKT 1162
Score = 45.1 bits (105), Expect = 1e-04
Identities = 61/295 (20%), Positives = 122/295 (41%), Gaps = 35/295 (11%)
Query: 135 KVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVL----ELEKDTAATGEQ 190
++ R +H+ T E E+ + G + +A ++ L + +L++ T E
Sbjct: 2620 ELQREMHEMAQKTAELQEE-----LSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSEL 2674
Query: 191 HSRLRQENLQLVHRANALEEQLKEQELRACEM------VLEETRRQKELLCKMEREKSIE 244
L + V + + E++ E +LR E +L +T +Q E+ + REK
Sbjct: 2675 KKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTS 2734
Query: 245 IEN-LQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRR 303
E L ++ ++D S LKA + LEE K+ +D ++ + +L +E E +
Sbjct: 2735 KEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN-QLKKENERAQG 2793
Query: 304 MGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRAR 363
L Q + +KE Q+ +L +L+A Q + ++ ++ +
Sbjct: 2794 KMKLLIKSCKQLEEEKEILQK------------ELSQLQAAQEKQKTGTV------MDTK 2835
Query: 364 ESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISS 418
EL E++ LK+ ++ +E + +L I K + E+ A + S
Sbjct: 2836 VDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCS 2890
Score = 44.3 bits (103), Expect = 2e-04
Identities = 57/261 (21%), Positives = 109/261 (41%), Gaps = 24/261 (9%)
Query: 189 EQHSRLRQENLQLVHRANALE-------EQLKEQELRACEMV--LEETRRQKELLCKMER 239
E+ +LR +L R A E +QLKE E A + +E R+ E+ +
Sbjct: 2294 EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQE 2353
Query: 240 EKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQE 299
++E EN + ++ L + + L+ ++ + EK+ L +E++ R+SE +
Sbjct: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413
Query: 300 NKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYH 359
+ L + + + KE + +E L+ QL+ L R +++ +
Sbjct: 2414 INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKEL----------NERVAALHNDQEA 2463
Query: 360 SRARESELEQEVRRLKQDNRNLKEQNEELNGQIITL--SIQGAKSLFSTAFSESLAAEIS 417
+A+E L +V L+ + L + +E I L S+ G + L +
Sbjct: 2464 CKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDG-KQKLEKKDE 2522
Query: 418 SVSRDELMEAIQKQEEINFRL 438
+SR L IQ QE++ +L
Sbjct: 2523 EISR--LKNQIQDQEQLVSKL 2541
Score = 40.0 bits (92), Expect = 0.004
Identities = 37/166 (22%), Positives = 76/166 (45%), Gaps = 14/166 (8%)
Query: 252 LQQLDEENSELRSCTPCLKANIERLEEEK-------QKLLDEIESLTLRLSEEQENKRRM 304
L QL +N ELR+ L+ ++ E+E Q+L ++E + L E+++ +
Sbjct: 280 LDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKC 339
Query: 305 GDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARE 364
D L Q+ + L + L+K E L QR+ S+ E + +E
Sbjct: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC------QRQNAESARCSLEQKIKEKE 393
Query: 365 SELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSE 410
E ++E+ R ++ + L ++ ++ + +T +Q AK++ + +E
Sbjct: 394 KEFQEELSRQQRSFQTLDQECIQMKAR-LTQELQQAKNMHNVLQAE 438
Score = 37.7 bits (86), Expect = 0.022
Identities = 67/315 (21%), Positives = 131/315 (41%), Gaps = 47/315 (14%)
Query: 157 ELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQE 216
E + E++++ +V LELEK G ++ + L N L +++++ +
Sbjct: 2462 EACKAKEQNLSSQV-----ECLELEKAQLLQGLDEAK--NNYIVLQSSVNGLIQEVEDGK 2514
Query: 217 LRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERL 276
+ E EE R K + E+ S ++ ++ Q E+N ELR+ T L+ I+ L
Sbjct: 2515 QKL-EKKDEEISRLKNQIQDQEQLVS-KLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL 2572
Query: 277 EEEKQKLLDEIESL---------TLRLSE-------EQENKRRMGD-RLSHERHQF-QRD 318
+ + L D +E L L L++ E+ NK + L E H+ Q+
Sbjct: 2573 QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKT 2632
Query: 319 KEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQ----------------EYHSRA 362
E +EL + + LQLL E + + + + L+ E +
Sbjct: 2633 AELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKV 2692
Query: 363 RESELEQEVRRLKQDNRN---LKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSV 419
RE E ++R + + ++ L + N++ +I T + S S+ L ++
Sbjct: 2693 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR-EKLTSKEECLSSQKLEIDLLKS 2751
Query: 420 SRDELMEAIQKQEEI 434
S++EL +++ +I
Sbjct: 2752 SKEELNNSLKATTQI 2766
Score = 36.6 bits (83), Expect = 0.049
Identities = 49/227 (21%), Positives = 96/227 (42%), Gaps = 27/227 (11%)
Query: 163 EEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQL--KEQELRAC 220
E + +++ + R+ E EK + + L N Q E+L KE+ L +
Sbjct: 2689 EGKVREEIAEYQLRLHEAEK------KHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQ 2742
Query: 221 EMVLEETRRQKELLCK--------MEREKSIEIENLQTRLQQLDEENSELRSCTPCLKAN 272
++ ++ + KE L +E K +++NL+ + QL +EN + L +
Sbjct: 2743 KLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKY-VNQLKKENERAQGKMKLLIKS 2801
Query: 273 IERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQ 332
++LEEEK+ L E+ L E+Q+ M ++ + + KE +E ++ +
Sbjct: 2802 CKQLEEEKEILQKELSQLQAA-QEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860
Query: 333 LEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNR 379
L+ L + E+ + Q H +++S KQD+R
Sbjct: 2861 LDKYCSLLISHEKLEKAKEMLETQVAHLCSQQS---------KQDSR 2898
Score = 35.8 bits (81), Expect = 0.084
Identities = 51/285 (17%), Positives = 118/285 (41%), Gaps = 49/285 (17%)
Query: 164 EDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMV 223
+ + K LE+++ +L +D + + R +LE+++KE
Sbjct: 351 DQASTKYTALEQKLKKLTEDLSCQRQNAESARC----------SLEQKIKE--------- 391
Query: 224 LEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKL 283
+E Q+EL + ++++ E +Q + +L +E + ++ L+A +++L KQ+L
Sbjct: 392 -KEKEFQEELSRQQRSFQTLDQECIQMK-ARLTQELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 284 LDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEA 343
+ +E +L ++ FQ + EL + + + LLK +
Sbjct: 450 ENNLEEFKQKLCRAEQ--------------AFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 344 EQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRN----LKEQNEELNGQIITLSIQG 399
EQ+ + + + + ++ + +K N + L++ E++N Q +L+++
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 400 AKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDR 444
K LA RD + ++K+E +L D + +
Sbjct: 556 LK----------LAVADLEKQRDCSQDLLKKREHHIEQLNDKLSK 590
Score = 33.9 bits (76), Expect = 0.32
Identities = 52/233 (22%), Positives = 98/233 (42%), Gaps = 21/233 (9%)
Query: 207 ALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDE-------EN 259
ALEE + RA + + +E Q + L K ++++ ++++L+ LQ+ + E
Sbjct: 4 ALEEWKEGLPTRALQKI-QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEG 62
Query: 260 SELRSCTPCLKANIERLEEEKQKLLDEIE--SLTLRLSEEQENK-----RRMGDRLSHER 312
+ L+ L E LE+ KQK+ E++ + E Q N ++ L +
Sbjct: 63 TNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 313 HQFQRDKEATQELIEDLR--KQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARE--SELE 368
+ +R ++A Q L + + L Q S L+E +++ E LE
Sbjct: 123 SELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLE 182
Query: 369 QEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSR 421
EV+ L+ + +N + I Q + S+FS E + +SS S+
Sbjct: 183 AEVKALQAKKASQTLPQATMNHRDIARH-QASSSVFSWQ-QEKTPSHLSSNSQ 233
Score = 31.6 bits (70), Expect = 1.6
Identities = 53/259 (20%), Positives = 102/259 (39%), Gaps = 26/259 (10%)
Query: 192 SRLRQENLQLVHRANALEE---------QLKEQELRACEMVLEETRRQKELLCKMEREKS 242
+ L++EN +L+ +LE+ Q+KE ++ E L ++Q E L + +
Sbjct: 63 TNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCK 122
Query: 243 IEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKR 302
E+E Q Q D L C K L + + E L + ++E E ++
Sbjct: 123 SELERSQQAAQSAD---VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERK 179
Query: 303 RMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRA 362
R+ + + + K+A+Q L + + H + + +A SS Q+ + +
Sbjct: 180 RLEAEV-----KALQAKKASQTLPQ---ATMNHRDIARHQAS-----SSVFSWQQEKTPS 226
Query: 363 RESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRD 422
S Q + + + +E+ TL I G + S+ F S + + +
Sbjct: 227 HLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQI-GKRDANSSFFDNSSSPHLLDQLKA 285
Query: 423 ELMEAIQKQEEINFRLQDY 441
+ E K E+ RLQ +
Sbjct: 286 QNQELRNKINELELRLQGH 304
Score = 29.6 bits (65), Expect = 6.0
Identities = 44/278 (15%), Positives = 111/278 (39%), Gaps = 59/278 (21%)
Query: 214 EQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEE--------------- 258
++++ ++ ++ET + L + ++ ++E+L +++LD +
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC 1825
Query: 259 ------NSELRSCTPCLKANIERLEEEKQKLLDEIE-----SLTLRLSEEQENKRRMGDR 307
EL+ L +E + Q+LL +E + L + ++ ++ +GD
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDN 1885
Query: 308 LSHERHQFQR---DKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHS---- 360
++ ++ D E I + +EH + L LEA+ ++ + L++ +
Sbjct: 1886 VAKVNDSWKERFLDVENELSRIRSEKASIEH-EALYLEADLEVVQTEKLCLEKDNENKQK 1944
Query: 361 -------------------RARESELEQEVRRLKQDNRNLKEQNEELNGQ----IITLSI 397
R + ++ L Q + +KE+ +EL + + +
Sbjct: 1945 VIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQV 2004
Query: 398 QGAKSLFSTAFSESLAAEISSVSRDE--LMEAIQKQEE 433
A+ T ++L++++S + +D+ L E +Q E+
Sbjct: 2005 AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEK 2042
>gi|237858621 polyamine modulated factor 1 binding protein 1 isoform
b [Homo sapiens]
Length = 882
Score = 71.2 bits (173), Expect = 2e-12
Identities = 72/290 (24%), Positives = 130/290 (44%), Gaps = 31/290 (10%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMV--------- 223
LE V E ++D + E + Q +Q + N+LEE +++ L A +
Sbjct: 296 LEMTVKEAKQDKSKEAE--CKALQAEVQKLK--NSLEEAKQQERLAAQQAAQCKEEAALA 351
Query: 224 ---LEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK 280
LE+T+R+ + ++++K+ I+ LQ LQ L +E+S + +E L E
Sbjct: 352 GCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLEL 411
Query: 281 QKLLDEIESLTLRLSEEQ----ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL 336
+ L ++E+ + Q E +M D L +HQ + +L EDL+ E
Sbjct: 412 SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ---EAT 468
Query: 337 QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLS 396
+LL+ + EQ + L E A E +++ + LK+++R L+E+NE L ++ S
Sbjct: 469 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 528
Query: 397 IQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRII 446
Q SL S+ + +L + I Q+E LQ +D+ +
Sbjct: 529 TQLESSLNKYNTSQQVI--------QDLNKEIALQKESLMSLQAQLDKAL 570
Score = 40.4 bits (93), Expect = 0.003
Identities = 63/275 (22%), Positives = 111/275 (40%), Gaps = 26/275 (9%)
Query: 178 LELEKDTAATGEQH---SRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELL 234
L+ + D A E+H + + +E + R +A + Q L V ET+ ++ L
Sbjct: 562 LQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSL 621
Query: 235 CKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK---QKLLDEIESLT 291
+ + +K+ E + +++ + N+ELR L+ + E E K L+E+
Sbjct: 622 TQTQEKKAQLEEEIIAYEERMKKLNTELRK----LRGFHQESELEVHAFDKKLEEMSCQV 677
Query: 292 LRLSEEQENKRRMGDRLSHERHQFQRDKEATQE-LIEDLRKQ--LEHLQLLKLEAEQRRG 348
L+ ++ +N +M + +FQ + A +E L+ED ++ L + K RG
Sbjct: 678 LQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRG 737
Query: 349 RSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAF 408
M + LEQ ++ K N L Q E I LS G K T
Sbjct: 738 NDQIM-----------TNLEQWAKQQKVANEKLGNQLREQVKYIAKLS--GEKDREPTRA 784
Query: 409 SESLAAEISSVSRDELMEAIQKQEEINFRLQDYID 443
S SS S L + ++ N +L+ I+
Sbjct: 785 SSPNTTRPSSPSHSHLHSVMVHLQQENKKLKKEIE 819
Score = 35.0 bits (79), Expect = 0.14
Identities = 37/156 (23%), Positives = 64/156 (41%), Gaps = 12/156 (7%)
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR----- 293
+E + + ++ Q D+ ELR+ C A + E+ KL + S T
Sbjct: 91 QETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPP 150
Query: 294 -LSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSS 352
SEE E+ +++ L ++ E Q L++DLR +LE + +EQ+R
Sbjct: 151 SSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV------SEQKRNIMKD 204
Query: 353 MGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEEL 388
M E E + R +D L+ + +EL
Sbjct: 205 MMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 240
>gi|237858619 polyamine modulated factor 1 binding protein 1 isoform
a [Homo sapiens]
Length = 1007
Score = 71.2 bits (173), Expect = 2e-12
Identities = 72/290 (24%), Positives = 130/290 (44%), Gaps = 31/290 (10%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMV--------- 223
LE V E ++D + E + Q +Q + N+LEE +++ L A +
Sbjct: 441 LEMTVKEAKQDKSKEAE--CKALQAEVQKLK--NSLEEAKQQERLAAQQAAQCKEEAALA 496
Query: 224 ---LEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK 280
LE+T+R+ + ++++K+ I+ LQ LQ L +E+S + +E L E
Sbjct: 497 GCHLEDTQRKLQKGLLLDKQKADTIQELQRELQMLQKESSMAEKEQTSNRKRVEELSLEL 556
Query: 281 QKLLDEIESLTLRLSEEQ----ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL 336
+ L ++E+ + Q E +M D L +HQ + +L EDL+ E
Sbjct: 557 SEALRKLENSDKEKRQLQKTVAEQDMKMNDMLDRIKHQHREQGSIKCKLEEDLQ---EAT 613
Query: 337 QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLS 396
+LL+ + EQ + L E A E +++ + LK+++R L+E+NE L ++ S
Sbjct: 614 KLLEDKREQLKKSKEHEKLMEGELEALRQEFKKKDKTLKENSRKLEEENENLRAELQCCS 673
Query: 397 IQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRII 446
Q SL S+ + +L + I Q+E LQ +D+ +
Sbjct: 674 TQLESSLNKYNTSQQVI--------QDLNKEIALQKESLMSLQAQLDKAL 715
Score = 36.2 bits (82), Expect = 0.064
Identities = 51/243 (20%), Positives = 105/243 (43%), Gaps = 37/243 (15%)
Query: 178 LELEKDTAATGEQH---SRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELL 234
L+ + D A E+H + + +E + R +A + Q L V ET+ ++ L
Sbjct: 707 LQAQLDKALQKEKHYLQTTITKEAYDALSRKSAACQDDLTQALEKLNHVTSETKSLQQSL 766
Query: 235 CKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK---QKLLDEIESLT 291
+ + +K+ E + +++ + N+ELR L+ + E E K L+E+
Sbjct: 767 TQTQEKKAQLEEEIIAYEERMKKLNTELRK----LRGFHQESELEVHAFDKKLEEMSCQV 822
Query: 292 LRLSEEQENKRRMGDRLSHERHQFQRDKEATQE-LIED-------------------LRK 331
L+ ++ +N +M + +FQ + A +E L+ED R
Sbjct: 823 LQWQKQHQNDLKMLAAKEEQLREFQEEMAALKENLLEDDKEPCCLPQWSVPKDTCRLYRG 882
Query: 332 QLEHLQLLKLEAEQRRGRSSSMGLQ-----EYHSR--ARESELEQEVRRLKQDNRNLKEQ 384
+ + L+ A+Q++ + +G Q +Y ++ + L + L+Q+N+ LK++
Sbjct: 883 NDQIMTNLEQWAKQQKVANEKLGNQLREQVKYIAKLSGEKDHLHSVMVHLQQENKKLKKE 942
Query: 385 NEE 387
EE
Sbjct: 943 IEE 945
Score = 35.0 bits (79), Expect = 0.14
Identities = 37/156 (23%), Positives = 64/156 (41%), Gaps = 12/156 (7%)
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR----- 293
+E + + ++ Q D+ ELR+ C A + E+ KL + S T
Sbjct: 236 QETQKRLSEVWQKVSQQDDLIQELRNKLACSNALVLEREKALIKLQADFASCTATHRYPP 295
Query: 294 -LSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSS 352
SEE E+ +++ L ++ E Q L++DLR +LE + +EQ+R
Sbjct: 296 SSSEECEDIKKILKHLQEQKDSQCLHVEEYQNLVKDLRVELEAV------SEQKRNIMKD 349
Query: 353 MGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEEL 388
M E E + R +D L+ + +EL
Sbjct: 350 MMKLELDLHGLREETSAHIERKDKDITILQCRLQEL 385
>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
Length = 1093
Score = 69.7 bits (169), Expect = 5e-12
Identities = 97/429 (22%), Positives = 176/429 (41%), Gaps = 46/429 (10%)
Query: 20 TYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEEPDHGALLLLPGRPHP 79
T E ++E TLV P E + + +G SA P C E+PD +L+ P
Sbjct: 369 TVESAEGKSEEVNETLVIPT--EEAEMEESGRSATPVNC----EQPD----ILVSSTPIN 418
Query: 80 HGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLTPSPTKRLSSKKVARY 139
GQ+V+ + + AE PE L + C FL KR +
Sbjct: 419 EGQTVLDKVAEQ--------CEPAESQPEALSEKEDVCKTVEFLNEKLEKREAQ---LLS 467
Query: 140 LHQSGALTMEALEDPSPELMEGPEED--IADKVVFLERRVLELEKDTAATGEQHSRLRQE 197
L + AL EA ++ E+ EE I+ +R+ E EK ++ ++E
Sbjct: 468 LSKEKALLEEAFDNLKDEMFRVKEESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKE 527
Query: 198 ----NLQLVHRANALE--EQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTR 251
+L R N+ E + LKE++ + ++ E + K+ L N+ +
Sbjct: 528 IKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHN---------SNIIKK 578
Query: 252 LQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHE 311
L+ D+EN + L ++ LEEE Q L ++ + +EN +++ + +
Sbjct: 579 LRAKDKENENM---VAKLNKKVKELEEELQHLKQVLDGKEEVEKQHRENIKKLNSMVERQ 635
Query: 312 RHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEV 371
++D Q +++L ++ +Q L++ + S A+E+ L +E+
Sbjct: 636 ----EKDLGRLQVDMDELEEKNRSIQ-AALDSAYKELTDLHKANAAKDSEAQEAALSREM 690
Query: 372 RRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQ 431
+ ++ + L++ EE Q TL+IQ + +E AA R E+ E Q+
Sbjct: 691 KAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRL 750
Query: 432 EEINFRLQD 440
+E R Q+
Sbjct: 751 QEAENRNQE 759
Score = 45.4 bits (106), Expect = 1e-04
Identities = 65/280 (23%), Positives = 108/280 (38%), Gaps = 64/280 (22%)
Query: 157 ELMEGPEE---DIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQL------------ 201
++++G EE + + L V EKD L ++N +
Sbjct: 609 QVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKELT 668
Query: 202 -VHRANALEE------------QLKEQELRACEMVLEETRRQKELLC------------- 235
+H+ANA ++ + KE+ A E EE R+Q+E L
Sbjct: 669 DLHKANAAKDSEAQEAALSREMKAKEELSAALEKAQEEARQQQETLAIQVGDLRLALQRT 728
Query: 236 -----KMEREKSIEIENLQTRLQQLDEENSEL----RSCTPCLKANIERLEEEKQKLLDE 286
+ E EI LQ RLQ+ + N EL S T L IE L+
Sbjct: 729 EQAAARKEDYLRHEIGELQQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSS 788
Query: 287 IESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQR 346
E L LS+ R+G+ + +R++ AT+EL+ + +Q+ +E++
Sbjct: 789 WEKLEKNLSD------RLGESQTLLAAAVERERAATEELLAN------KIQMSSMESQNS 836
Query: 347 --RGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQ 384
R +S Q + R +LE E R + + NLK++
Sbjct: 837 LLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDE 876
Score = 40.4 bits (93), Expect = 0.003
Identities = 79/349 (22%), Positives = 142/349 (40%), Gaps = 57/349 (16%)
Query: 128 TKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVL-ELEKDTAA 186
T++ +++K H+ G L E E ++++ V R +L ++E A
Sbjct: 728 TEQAAARKEDYLRHEIGELQQRLQE------AENRNQELSQSVSSTTRPLLRQIENLQAT 781
Query: 187 TGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIE 246
G Q S E L+ L ++L E + V E +ELL + S+E +
Sbjct: 782 LGSQTSSW--EKLE-----KNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSMESQ 834
Query: 247 NLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESL----TLRLSEEQENKR 302
N R +ENS ++ K + +LE+E + E+E+L L E ++ K
Sbjct: 835 NSLLR-----QENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEETRKEKT 889
Query: 303 RMGDRLSHERHQFQRDKEA---TQELIEDLRKQLEHLQLLKLEAEQRRGRSSSM------ 353
+ +L ER + +++++ TQE I++ + + + + RSSS+
Sbjct: 890 LLNSQLEMERMKVEQERKKAIFTQETIKEKER-----KPFSVSSTPTMSRSSSISGVDMA 944
Query: 354 GLQ-------EYHSR--------ARESELEQEVRRLKQDN--RNLKEQNEELNGQIITLS 396
GLQ E H A S L VR + NL+ Q + G+I L
Sbjct: 945 GLQTSFLSQDESHDHSFGPMPISANGSNLYDAVRMGAGSSIIENLQSQLKLREGEITHLQ 1004
Query: 397 IQ-GAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDR 444
++ G + +E L + DEL E +++ ++ +L+D R
Sbjct: 1005 LEIGNLEKTRSIMAEELVKLTN--QNDELEEKVKEIPKLRTQLRDLDQR 1051
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 68.9 bits (167), Expect = 9e-12
Identities = 49/237 (20%), Positives = 121/237 (51%), Gaps = 13/237 (5%)
Query: 157 ELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQE 216
E M EE + + + + ++ K GEQ +++++ Q+ + EEQ+++QE
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQ----EEQMRKQE 261
Query: 217 LRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERL 276
+ E E+ R Q+E + K ++E++ + E + +Q+ E+ ++R ++ E++
Sbjct: 262 EQMREQE-EQMREQEEQMLK-QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQM 319
Query: 277 EEEKQKLLDEIESLTLRLSEEQENKRRM---GDRLSHERHQFQRDKEATQELIEDLRKQL 333
E+++++ + E + + + E K +M +++ + Q Q+ +E ++ E +RKQ
Sbjct: 320 REQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQE 379
Query: 334 EHL----QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNE 386
E + + ++ + EQ + MG Q+ R +E ++ ++ ++++ ++ EQ E
Sbjct: 380 EQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 65.9 bits (159), Expect = 8e-11
Identities = 45/219 (20%), Positives = 110/219 (50%), Gaps = 18/219 (8%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKME 238
+++K GEQ ++R++ Q+ + EEQ+++QE + E+ R+Q+E + + E
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQMGEQ----EEQVQKQE-EQVQKQEEQMRKQEEQMREQE 268
Query: 239 REKSIEIENLQTRLQQLD------EENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL 292
+ + E + + +Q + E+ ++R ++ E++ E+++++ ++ E +
Sbjct: 269 EQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK 328
Query: 293 RLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSS 352
+ + E K +M + ++ Q + +E E E ++KQ E ++ + EQ R +
Sbjct: 329 QEEQMWEQKEQMWE----QKEQMWKQEEQMGEQEEQMQKQEEQ---VRKQEEQMRKQEEQ 381
Query: 353 MGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQ 391
M QE R +E ++ ++ ++ + ++EQ E++ Q
Sbjct: 382 MRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQ 420
Score = 62.8 bits (151), Expect = 6e-10
Identities = 44/210 (20%), Positives = 104/210 (49%), Gaps = 11/210 (5%)
Query: 188 GEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIEN 247
GEQ +++++ Q+ + EEQ+++QE + E E+ ++Q+E + K E + + E
Sbjct: 209 GEQEEQMQKQEEQMGEQ----EEQMRKQEEQMGEQE-EQVQKQEEQVQKQEEQMRKQEEQ 263
Query: 248 LQTRLQQLDEENSELRSCTPCLKANIERLEEEKQ--KLLDEIESLTLRLSEEQENKRRMG 305
++ + +Q+ E+ ++ + + E+E+Q + +++ ++ E++E R
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323
Query: 306 DRLSHERHQFQRDKEATQELIEDLRKQLEHL----QLLKLEAEQRRGRSSSMGLQEYHSR 361
+++ + Q KE E E + KQ E + + ++ + EQ R + M QE R
Sbjct: 324 EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMR 383
Query: 362 ARESELEQEVRRLKQDNRNLKEQNEELNGQ 391
+E ++ ++ ++ + + EQ E++ Q
Sbjct: 384 KQEEQMRKQEEQMGEQKEQMGEQKEQMREQ 413
Score = 60.8 bits (146), Expect = 2e-09
Identities = 47/212 (22%), Positives = 103/212 (48%), Gaps = 12/212 (5%)
Query: 189 EQHSRLRQENLQLVHRANAL---EEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEI 245
EQ ++R++ Q+ + + EEQ+ EQE + E+ Q+E + K E + +
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQE-EQMQKQEEQMGEQEEQMRKQEEQMGEQE 240
Query: 246 ENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL--RLSEEQENKRR 303
E +Q + +Q+ ++ ++R ++ E++ E+++++L + E + E++E R
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300
Query: 304 MGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRAR 363
+++ + Q + +E +E E + KQ E + K EQ + M QE +
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQK---EQMWEQKEQMWKQEEQMGEQ 357
Query: 364 ESEL---EQEVRRLKQDNRNLKEQNEELNGQI 392
E ++ E++VR+ ++ R +EQ + Q+
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389
Score = 50.1 bits (118), Expect = 4e-06
Identities = 45/204 (22%), Positives = 99/204 (48%), Gaps = 21/204 (10%)
Query: 189 EQHSRLRQENLQLVHRANALEEQ---LKEQELRACEMVLEETRRQKELLCKMEREKSIEI 245
EQ ++R++ Q+ + + EQ ++EQE + E + Q+ + + E + +
Sbjct: 154 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE-GQMGEQEGQMGEQEEQMGEQE 212
Query: 246 ENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMG 305
E +Q + +Q+ E+ ++R + + EE+ QK ++++ ++ +++E R
Sbjct: 213 EQMQKQEEQMGEQEEQMRK----QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQE 268
Query: 306 DRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARES 365
+++ + Q + KE T++ E+ + E EQ R + M QE R +E
Sbjct: 269 EQMREQEEQMLKQKEQTEQ--EEQTGEQE---------EQMREQEEQMREQEEQMREQEE 317
Query: 366 EL-EQEVRRLKQDNRNLKEQNEEL 388
++ EQE + KQ+ + + EQ E++
Sbjct: 318 QMREQEEQMGKQEEQ-MWEQKEQM 340
Score = 49.7 bits (117), Expect = 6e-06
Identities = 50/244 (20%), Positives = 114/244 (46%), Gaps = 18/244 (7%)
Query: 153 DPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQ- 211
D P EG + +V E +V E E EQ ++R++ Q+ + + EQ
Sbjct: 44 DKIPLPQEGQVREQEGQVREQEGQVREQEGQVR---EQEGQVREQEGQVREQEGQVREQE 100
Query: 212 --LKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQ--QLDEENSELRSCTP 267
++EQE + E + ++ ++ E+E + + Q R Q Q+ E+ ++R
Sbjct: 101 GQVREQEGQVREQEGQVREQEGQV---REQEGQVREQEGQVREQEGQVREQEGQVREQEG 157
Query: 268 CLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIE 327
++ ++ E++ ++ ++ + + + +E + +MG+ + Q +E E E
Sbjct: 158 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGE----QEGQMGEQEEQMGEQEE 213
Query: 328 DLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEE 387
++KQ E + + EQ R + MG QE + +E +++++ ++++ ++EQ E+
Sbjct: 214 QMQKQEEQMGE---QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQ 270
Query: 388 LNGQ 391
+ Q
Sbjct: 271 MREQ 274
Score = 31.2 bits (69), Expect = 2.1
Identities = 34/156 (21%), Positives = 67/156 (42%), Gaps = 8/156 (5%)
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDE--IESLTLRLSE 296
+EK+ E LQ LQ ++ E SE++ LK +LE +K L E + ++ E
Sbjct: 10 KEKNAE---LQEELQLVETEKSEIQLHIKELK---RKLETDKIPLPQEGQVREQEGQVRE 63
Query: 297 EQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQ 356
++ R ++ + Q + + +E +R+Q ++ + + ++ G+ Q
Sbjct: 64 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 123
Query: 357 EYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI 392
+ E E +VR + R + Q E GQ+
Sbjct: 124 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 159
Score = 29.3 bits (64), Expect = 7.8
Identities = 45/227 (19%), Positives = 96/227 (42%), Gaps = 16/227 (7%)
Query: 210 EQLKEQ--ELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQ-QLDEENSELRSCT 266
E+LKE+ EL+ E+ L ET + + L E ++ +E + + + Q+ E+ ++R
Sbjct: 7 EELKEKNAELQE-ELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVRE-- 63
Query: 267 PCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELI 326
+ + E + ++ ++ ++ E++ R ++ + Q + + +E
Sbjct: 64 --QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 327 EDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNE 386
+R+Q ++ + + ++ G+ ++E + RE E +VR + R + Q
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQ-----VREQEGQVREQE--GQVREQEGQVREQEGQVR 174
Query: 387 ELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
E GQ+ Q + E E E E +QKQEE
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGE-QEEQMGEQEEQMQKQEE 220
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 67.8 bits (164), Expect = 2e-11
Identities = 75/318 (23%), Positives = 145/318 (45%), Gaps = 47/318 (14%)
Query: 157 ELMEGPEEDIADKVVFL-ERRVLELEKDTAATGEQHSRLR-----------------QEN 198
EL E P++ + +V L R+L+LE + + + LR +EN
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Query: 199 LQLVHRANALEEQL--KEQELRACEMVLEETRRQKELLCKMEREKSIEI--ENLQTRLQQ 254
+L + LE ++ ++Q L+ C+ + ++ ++K L EK+IE EN + +++
Sbjct: 501 QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKI 555
Query: 255 LDEENSELRSCTPCLK--------ANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGD 306
L++EN L L+ A ++ +E+E + L + I+ + +LS+ + KR++
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 307 RLSHERHQFQRDKEATQELIEDLRKQLEHLQL----LKLEAEQRRGRSSSMGLQEYHSRA 362
L H + + +R +E EL L K+ E LQ LK+ E+ E +R
Sbjct: 616 ELEHYKEKGERAEELENEL-HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674
Query: 363 RESELEQ------EVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEI 416
+ L+ ++ L+++N L E+N EL + +L K ++ L +E
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 417 SSVSRD-ELMEAIQKQEE 433
+ + EL++A K+ E
Sbjct: 735 EQLKKGLELLKASFKKTE 752
Score = 58.5 bits (140), Expect = 1e-08
Identities = 71/313 (22%), Positives = 134/313 (42%), Gaps = 36/313 (11%)
Query: 159 MEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELR 218
+E ++ +++ L+R+ + L++ Q+++L+ EN L ++ +L Q + ++
Sbjct: 1072 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1131
Query: 219 AC------EMVLEETRRQKEL---LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCL 269
E V++E K L L K + + E + + L ++ L+S L
Sbjct: 1132 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1191
Query: 270 KANIERLEEEKQKLLDE---IESLTLRLSEEQEN---------------KRRMG--DRLS 309
+ LE+ +LL + +E L L EQE K+ G DRL+
Sbjct: 1192 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1251
Query: 310 HERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRA--RESEL 367
H Q ++ E Q ++L+ L + +L EQ R + L+E + + ++L
Sbjct: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKL-----EQTRLEAEFSKLKEQYQQLDITSTKL 1306
Query: 368 EQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEA 427
+ L Q NL+E+N L QI TL +Q L S+ L D+L E
Sbjct: 1307 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
Query: 428 IQKQEEINFRLQD 440
+++E++ ++ D
Sbjct: 1367 RRQKEKLEEKIMD 1379
Score = 52.4 bits (124), Expect = 9e-07
Identities = 62/264 (23%), Positives = 112/264 (42%), Gaps = 34/264 (12%)
Query: 131 LSSKKVARYLHQSGALTMEALEDPSPELME--GPEEDIADKVVFLERRVLELEKDTAATG 188
+S + H++ + LED +L++ G ED+ + + ++L K+
Sbjct: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
Query: 189 EQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKS---IEI 245
++ +L EN +L H + L L+ E++ + + K LL + E++ E
Sbjct: 1238 AEYKKLCGENDRLNHTYSQL--------LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1289
Query: 246 ENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMG 305
L+ + QQLD +++L + L LEEE + LLD+I++L L+ E
Sbjct: 1290 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 306 DRLSHERHQF-------QRDKEATQELIEDLRK--------------QLEHLQLLKLEAE 344
D E+ Q+ +R KE +E I D K L+ +L+K + +
Sbjct: 1350 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKD 1409
Query: 345 QRRGRSSSMGLQEYHSRARESELE 368
R R S+ L S + E L+
Sbjct: 1410 INRERQKSLTLTPTRSDSSEGFLQ 1433
Score = 49.7 bits (117), Expect = 6e-06
Identities = 69/302 (22%), Positives = 132/302 (43%), Gaps = 50/302 (16%)
Query: 140 LHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENL 199
+++ + ++ LE + EL++ DI V E V E K +Q N
Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT-----------QQMNN 923
Query: 200 QLVHRANALEE-QLKEQELRACEMVLEETRRQKELLCKMER--EKSIEIEN-----LQTR 251
L + LE+ L ++ L E +++R K L K+E +KS+EI+ L+ R
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSR-YKLLESKLESTLKKSLEIKEEKIAALEAR 982
Query: 252 LQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHE 311
L++ N +LR +K N E L++ +++E + +S E
Sbjct: 983 LEESTNYNQQLRQELKTVKKNYEALKQR----------------QDEERMVQSSPPISGE 1026
Query: 312 RHQFQRD-KEATQELIEDLRKQLE----------HLQLLKLEAEQRRGRSSSMGLQEYHS 360
++++R+ +E T+EL++ + +E Q LK + +Q +++++ Q
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086
Query: 361 RARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVS 420
+ + L+++ L+ N L+ +N LN Q +L Q A+ L SL E SV
Sbjct: 1087 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ---QSSLENENESVI 1143
Query: 421 RD 422
++
Sbjct: 1144 KE 1145
Score = 48.1 bits (113), Expect = 2e-05
Identities = 87/420 (20%), Positives = 176/420 (41%), Gaps = 93/420 (22%)
Query: 91 EEHFEDYGEGSEAE----LSPETLCNGQLGCSDPAFLTPSPTKRLS-----SKKVARYLH 141
+EH E E SE P + Q C P + LS +K R L
Sbjct: 205 DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264
Query: 142 QSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQL 201
Q LE+ + +L++ +E LE+ +EL+ RL+QEN+ L
Sbjct: 265 QE-------LEEKTEQLLDCKQE--------LEQMEIELK-----------RLQQENMNL 298
Query: 202 VHRANALE------EQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQL 255
+ A + + L+E+ +R ++ E +R +E+ +IE + R+++L
Sbjct: 299 LSDARSARMYRDELDALREKAVRVDKLESEVSRY---------KERLHDIEFYKARVEEL 349
Query: 256 DEENS------------------------ELRSCTPCLKANIERLEEEK---QKLLDEI- 287
E+N EL LKA + +E E+ +K ++E+
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 288 -ESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL---QLLKLEA 343
E++TL ++++Q + L E Q R E ++ + L ++ L +LLKLE
Sbjct: 410 EENMTLEMAQKQSMDESL--HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 344 EQRRGRSSSMGLQEYHSRARESE-LEQEVRRLKQDNRNLKEQNEELNGQII--TLSIQGA 400
E +S + ++E + E ++ +++++N+ L ++ E L +I+ S+Q
Sbjct: 468 E---NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 401 KSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 460
++L E E + + L E ++Q +I + +++++ + ++ + + E +
Sbjct: 525 QNLSKDLMKEKAQLE---KTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR 581
Score = 42.7 bits (99), Expect = 7e-04
Identities = 63/305 (20%), Positives = 129/305 (42%), Gaps = 61/305 (20%)
Query: 173 LERRVLELEKDTAATGEQ---HSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRR 229
LE + LE EK+ G + S + E L++ ++ +E Q ++ L +++
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 230 QKELLCKMEREKSIEIENLQT---RLQQLDEENSELRSCTPCLKANIERLEEEKQKLLD- 285
+ + L + +E L+ RL+QL++EN L T L+ + ++LE+E ++L
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 286 -EIESLTL-----------------------------RLSEEQENKRRMGDRLSHE---- 311
EI+ TL RL E ++ + + R + +
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 312 ---RHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELE 368
R +K TQ++ DL K L+ + L E+ S Y + ES+LE
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY--KLLESKLE 962
Query: 369 QEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAI 428
+++ + +KE+ ++ A+ ST +++ L E+ +V ++ EA+
Sbjct: 963 STLKK----SLEIKEEK---------IAALEARLEESTNYNQQLRQELKTVKKN--YEAL 1007
Query: 429 QKQEE 433
+++++
Sbjct: 1008 KQRQD 1012
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 67.8 bits (164), Expect = 2e-11
Identities = 75/318 (23%), Positives = 145/318 (45%), Gaps = 47/318 (14%)
Query: 157 ELMEGPEEDIADKVVFL-ERRVLELEKDTAATGEQHSRLR-----------------QEN 198
EL E P++ + +V L R+L+LE + + + LR +EN
Sbjct: 441 ELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
Query: 199 LQLVHRANALEEQL--KEQELRACEMVLEETRRQKELLCKMEREKSIEI--ENLQTRLQQ 254
+L + LE ++ ++Q L+ C+ + ++ ++K L EK+IE EN + +++
Sbjct: 501 QRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL-----EKTIETLRENSERQIKI 555
Query: 255 LDEENSELRSCTPCLK--------ANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGD 306
L++EN L L+ A ++ +E+E + L + I+ + +LS+ + KR++
Sbjct: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKK 615
Query: 307 RLSHERHQFQRDKEATQELIEDLRKQLEHLQL----LKLEAEQRRGRSSSMGLQEYHSRA 362
L H + + +R +E EL L K+ E LQ LK+ E+ E +R
Sbjct: 616 ELEHYKEKGERAEELENEL-HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK 674
Query: 363 RESELEQ------EVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEI 416
+ L+ ++ L+++N L E+N EL + +L K ++ L +E
Sbjct: 675 LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
Query: 417 SSVSRD-ELMEAIQKQEE 433
+ + EL++A K+ E
Sbjct: 735 EQLKKGLELLKASFKKTE 752
Score = 58.5 bits (140), Expect = 1e-08
Identities = 71/313 (22%), Positives = 134/313 (42%), Gaps = 36/313 (11%)
Query: 159 MEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELR 218
+E ++ +++ L+R+ + L++ Q+++L+ EN L ++ +L Q + ++
Sbjct: 1071 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1130
Query: 219 AC------EMVLEETRRQKEL---LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCL 269
E V++E K L L K + + E + + L ++ L+S L
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL 1190
Query: 270 KANIERLEEEKQKLLDE---IESLTLRLSEEQEN---------------KRRMG--DRLS 309
+ LE+ +LL + +E L L EQE K+ G DRL+
Sbjct: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLN 1250
Query: 310 HERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRA--RESEL 367
H Q ++ E Q ++L+ L + +L EQ R + L+E + + ++L
Sbjct: 1251 HTYSQLLKETEVLQTDHKNLKSLLNNSKL-----EQTRLEAEFSKLKEQYQQLDITSTKL 1305
Query: 368 EQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEA 427
+ L Q NL+E+N L QI TL +Q L S+ L D+L E
Sbjct: 1306 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
Query: 428 IQKQEEINFRLQD 440
+++E++ ++ D
Sbjct: 1366 RRQKEKLEEKIMD 1378
Score = 52.4 bits (124), Expect = 9e-07
Identities = 62/264 (23%), Positives = 112/264 (42%), Gaps = 34/264 (12%)
Query: 131 LSSKKVARYLHQSGALTMEALEDPSPELME--GPEEDIADKVVFLERRVLELEKDTAATG 188
+S + H++ + LED +L++ G ED+ + + ++L K+
Sbjct: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1236
Query: 189 EQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKS---IEI 245
++ +L EN +L H + L L+ E++ + + K LL + E++ E
Sbjct: 1237 AEYKKLCGENDRLNHTYSQL--------LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF 1288
Query: 246 ENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMG 305
L+ + QQLD +++L + L LEEE + LLD+I++L L+ E
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1348
Query: 306 DRLSHERHQF-------QRDKEATQELIEDLRK--------------QLEHLQLLKLEAE 344
D E+ Q+ +R KE +E I D K L+ +L+K + +
Sbjct: 1349 DLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKD 1408
Query: 345 QRRGRSSSMGLQEYHSRARESELE 368
R R S+ L S + E L+
Sbjct: 1409 INRERQKSLTLTPTRSDSSEGFLQ 1432
Score = 52.0 bits (123), Expect = 1e-06
Identities = 65/295 (22%), Positives = 124/295 (42%), Gaps = 37/295 (12%)
Query: 140 LHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQ-EN 198
+++ + ++ LE + EL++ DI V E V E K + + E
Sbjct: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Query: 199 LQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEE 258
+ L +EQ + + E LE T + K L K E+ I L+ RL++
Sbjct: 935 IGLNKERLLHDEQSTDDRYKLLESKLESTLK-KSLEIKEEK-----IAALEARLEESTNY 988
Query: 259 NSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRD 318
N +LR +K N E L++ +++E + +S E ++++R+
Sbjct: 989 NQQLRQELKTVKKNYEALKQR----------------QDEERMVQSSPPISGEDNKWERE 1032
Query: 319 -KEATQELIEDLRKQLE----------HLQLLKLEAEQRRGRSSSMGLQEYHSRARESEL 367
+E T+EL++ + +E Q LK + +Q +++++ Q + + L
Sbjct: 1033 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1092
Query: 368 EQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRD 422
+++ L+ N L+ +N LN Q +L Q A+ L SL E SV ++
Sbjct: 1093 QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ---QSSLENENESVIKE 1144
Score = 48.1 bits (113), Expect = 2e-05
Identities = 87/420 (20%), Positives = 176/420 (41%), Gaps = 93/420 (22%)
Query: 91 EEHFEDYGEGSEAE----LSPETLCNGQLGCSDPAFLTPSPTKRLS-----SKKVARYLH 141
+EH E E SE P + Q C P + LS +K R L
Sbjct: 205 DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264
Query: 142 QSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQL 201
Q LE+ + +L++ +E LE+ +EL+ RL+QEN+ L
Sbjct: 265 QE-------LEEKTEQLLDCKQE--------LEQMEIELK-----------RLQQENMNL 298
Query: 202 VHRANALE------EQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQL 255
+ A + + L+E+ +R ++ E +R +E+ +IE + R+++L
Sbjct: 299 LSDARSARMYRDELDALREKAVRVDKLESEVSRY---------KERLHDIEFYKARVEEL 349
Query: 256 DEENS------------------------ELRSCTPCLKANIERLEEEK---QKLLDEI- 287
E+N EL LKA + +E E+ +K ++E+
Sbjct: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
Query: 288 -ESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL---QLLKLEA 343
E++TL ++++Q + L E Q R E ++ + L ++ L +LLKLE
Sbjct: 410 EENMTLEMAQKQSMDESL--HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 344 EQRRGRSSSMGLQEYHSRARESE-LEQEVRRLKQDNRNLKEQNEELNGQII--TLSIQGA 400
E +S + ++E + E ++ +++++N+ L ++ E L +I+ S+Q
Sbjct: 468 E---NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
Query: 401 KSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK 460
++L E E + + L E ++Q +I + +++++ + ++ + + E +
Sbjct: 525 QNLSKDLMKEKAQLE---KTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR 581
Score = 42.7 bits (99), Expect = 7e-04
Identities = 59/292 (20%), Positives = 125/292 (42%), Gaps = 36/292 (12%)
Query: 173 LERRVLELEKDTAATGEQ---HSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRR 229
LE + LE EK+ G + S + E L++ ++ +E Q ++ L +++
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 230 QKELLCKMEREKSIEIENLQT---RLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDE 286
+ + L + +E L+ RL+QL++EN L T L+ + ++LE+E ++L +
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 287 IESLTLRLSE--------EQENKRRMGDRLSHERHQFQRDKEATQE-------------- 324
E L E E+ENK + + + R KE +E
Sbjct: 845 AEIKDTTLEENNVKIGNLEKENK-TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903
Query: 325 ---LIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNL 381
L EDL + Q + + E+ +GL + E + + L+ +
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLEST 963
Query: 382 KEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
+++ E+ + ++ A+ ST +++ L E+ +V ++ EA++++++
Sbjct: 964 LKKSLEIKEE--KIAALEARLEESTNYNQQLRQELKTVKKN--YEALKQRQD 1011
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 67.8 bits (164), Expect = 2e-11
Identities = 74/331 (22%), Positives = 148/331 (44%), Gaps = 61/331 (18%)
Query: 163 EEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQE------ 216
EE +++K +ER + E+D E+ R+EN L + NAL+ +L E+E
Sbjct: 587 EEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDL 646
Query: 217 -----------------LRACEMVLEETRRQ-KELLCKMEREKSIEIEN-----LQTRLQ 253
L++ E+ +E+ + + +L ++++ +IE ++ +++
Sbjct: 647 KEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIK 706
Query: 254 QLDEENSELRSCTPCLKANIERLEE----------EKQKLLDEIESLTLRLSEEQENKRR 303
QLD+E S R +A ++RL E +K K + E+ESLTLR ++Q K
Sbjct: 707 QLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKK-- 764
Query: 304 MGDRLSHERHQFQRDKEATQELIEDLRKQ-------LEHLQLLKLEAEQRRGRSSSMGLQ 356
+++ +H Q +K+ +L+E++R++ +HLQ+ +L + R +
Sbjct: 765 ----VANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKTRQELDATK 820
Query: 357 EYHSRARESELEQE-------VRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFS 409
+ ++S E+E + R KQ L+ + E L I A S +
Sbjct: 821 ARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKK 880
Query: 410 ESLAAEISSVSR--DELMEAIQKQEEINFRL 438
+ E+ ++ R D L+ +++Q + +L
Sbjct: 881 KKTQEEVMALKREKDRLVHQLKQQTQNRMKL 911
Score = 60.8 bits (146), Expect = 2e-09
Identities = 71/302 (23%), Positives = 131/302 (43%), Gaps = 48/302 (15%)
Query: 177 VLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCK 236
V+E++ A+ E++ R ++ +Q++ L + +E+E++ E+ ++ K + +
Sbjct: 379 VIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQ 438
Query: 237 MERE---KSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
+++E K E+ LQT+L+ L +NS+ + LK ++ E+ L E+++L LR
Sbjct: 439 LKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLR 498
Query: 294 LSEEQE--NK-------------------RRMGDRLSHERHQ---FQRDKEATQELIEDL 329
L E++ NK R M D L + + Q+ E QE + D
Sbjct: 499 LEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDK 558
Query: 330 RKQLEHLQ----------------LLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRR 373
KQL +L+ L LE L+E R LE E+
Sbjct: 559 DKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLE-EIES 617
Query: 374 LKQDNRNLKEQNEELNGQII--TLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQ 431
+++N++LKE+ L ++ S+ K S+ S L + S + +E QK+
Sbjct: 618 FRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIE--QKK 675
Query: 432 EE 433
EE
Sbjct: 676 EE 677
Score = 35.8 bits (81), Expect = 0.084
Identities = 48/214 (22%), Positives = 92/214 (42%), Gaps = 29/214 (13%)
Query: 211 QLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLK 270
+L E+ R + + ++ LL K E + IE + L DE +L
Sbjct: 257 ELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 316
Query: 271 ANIERLEE--EKQKLLDEIES----LTLRLSEEQENKRRMGDRLSHERHQFQRD---KEA 321
+ LE+ E+ + + E ES L + L ++++ + + L H R Q Q + +A
Sbjct: 317 LPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREEL-HRRSQLQPEPAKTKA 375
Query: 322 TQELIE-----------DLRKQLEHLQLLK----LEAEQRRGRSSSMGLQEYHSRARESE 366
Q +IE ++R + +Q+LK L E R + + + HS+ +++
Sbjct: 376 LQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTK 435
Query: 367 LEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGA 400
++Q LKQ+ + + L ++ TLS Q +
Sbjct: 436 IDQ----LKQELSKKESELLALQTKLETLSNQNS 465
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 67.4 bits (163), Expect = 3e-11
Identities = 74/314 (23%), Positives = 135/314 (42%), Gaps = 35/314 (11%)
Query: 159 MEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELR 218
+E E++ ++ LE LE++ + + RQ N L RA L +QL+ ++
Sbjct: 721 LEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI 780
Query: 219 ACEMVLEETRRQ------KELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKAN 272
L+ ++ K+ L K E EK I ++ +T Q+ ++ EL +
Sbjct: 781 VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE 840
Query: 273 IERLEEEKQKLLDEIESLTLRLSE------------EQENKRRMGDRLSHER------HQ 314
+++++ EK+ L+ E+ ++ +LS+ E+EN++ L E+ HQ
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
Query: 315 FQRDKEAT----QELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQE 370
Q E T +EL + L K+ E LKLE + + + E +L+
Sbjct: 901 LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 371 VRRLKQDNRNLKEQNEELNGQIITLSIQGAK-----SLFSTAFSESLAAEISSVSRDELM 425
+ LKQ + K+Q E L G++ +Q + T ++ LAAE +S L
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKIS--VLQ 1018
Query: 426 EAIQKQEEINFRLQ 439
+K +E +LQ
Sbjct: 1019 NNYEKSQETFKQLQ 1032
Score = 62.8 bits (151), Expect = 6e-10
Identities = 66/279 (23%), Positives = 129/279 (46%), Gaps = 22/279 (7%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQK-- 231
+ ++++ K AT EQ S +++ LQ R AL++ KE+ L+ E+V E+++ +
Sbjct: 1073 QNKLIQELKTAKATLEQDSAKKEQQLQ--ERCKALQDIQKEKSLKEKELVNEKSKLAEIE 1130
Query: 232 ELLCKMERE-------------KSI-EIENLQTRLQQLDEENSELRSCTPCLKANIERLE 277
E+ C+ E+E +SI EI NL+ Q L ++ EL+ LKA +E+ +
Sbjct: 1131 EIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK 1190
Query: 278 EEKQKLLDEIESLTLRLSEE-QENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL 336
+Q L D+++ L +E E + ++ + + ++ +E +L + E+L
Sbjct: 1191 RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250
Query: 337 QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLS 396
+K E + + R S + Q R + LE V+ + + R L E+ + G+I L
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQ 1310
Query: 397 IQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEIN 435
K L ++ A + + R+ I+ + +N
Sbjct: 1311 ---TKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALN 1346
Score = 57.8 bits (138), Expect = 2e-08
Identities = 70/302 (23%), Positives = 138/302 (45%), Gaps = 55/302 (18%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQE----------------NLQLVHRANALEEQLKEQE 216
L ++LE E+ GE H RL+++ +LQL + + LEEQLKE+
Sbjct: 419 LHSKLLETERQL---GEAHGRLKEQRQLSSEKLMDKEQQVADLQL--KLSRLEEQLKEKV 473
Query: 217 LRACEMV--LEETRRQKELLCKMEREKSIEIENLQTRLQQL-------DEENSELRSCTP 267
+ E+ L++T++Q + +++ + ++ Q L+Q+ D++ L +
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 268 CLKANIERLEEEKQKLLDEI---ESLTLRLSEEQENKRRMGDRLSHE----RHQFQRDKE 320
K NI LE+E++ L +I E T L++ QE + ++++ ++Q + K+
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 321 ATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRN 380
A + L + +++Q HL+ A Q R S + E +S+ ES+ ++ Q +
Sbjct: 594 AQENLHDQVQEQKAHLR-----AAQDRVLSLETSVNELNSQLNESK-----EKVSQLDIQ 643
Query: 381 LKEQNEELNGQIITLSIQGAKSLFSTAFSESL--AAEISSVSRDELMEAIQKQEEINFRL 438
+K + E + LS + AK+ L A + EL + + +++ +L
Sbjct: 644 IKAKTE------LLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKL 697
Query: 439 QD 440
QD
Sbjct: 698 QD 699
Score = 46.6 bits (109), Expect = 5e-05
Identities = 64/311 (20%), Positives = 129/311 (41%), Gaps = 44/311 (14%)
Query: 168 DKVVFLERRVLELEKDTAATGEQHSRL------RQENLQLVHRANALEEQLKEQELRACE 221
D+V+ LE V EL + E+ S+L + E L A + + L +
Sbjct: 614 DRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQ 673
Query: 222 MVLEETRRQ--------KELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANI 273
L++ +++ ++ K++ +K L++ L++ E+ L T L+ I
Sbjct: 674 NALQDKQQELNKITTQLDQVTAKLQ-DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQI 732
Query: 274 ERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQL 333
++LE + ++ E L ++++ + R + Q + +KE DL+K+
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 334 EHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQD----NRNLKEQNEELN 389
E L+ +K + ++ E+E + LKQD ++ K Q+EELN
Sbjct: 793 EALESIKQKLTKQ---------------------EEEKQILKQDFETLSQETKIQHEELN 831
Query: 390 GQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAI 449
+I T + K E+L E+S+V +D+L + + + + AI
Sbjct: 832 NRIQTTVTELQKVKME---KEALMTELSTV-KDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 450 METNPSILEVK 460
++ + E+K
Sbjct: 888 LDLEKTCKELK 898
Score = 46.2 bits (108), Expect = 6e-05
Identities = 62/283 (21%), Positives = 126/283 (44%), Gaps = 21/283 (7%)
Query: 167 ADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHR-ANALEEQLKEQELRACEMVLE 225
AD++ V + D+ GE + L+++++ L+ + L+ LKE++ + E+ E
Sbjct: 53 ADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKE 112
Query: 226 ETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLD 285
+ Q L + E + + + LQ L+++ E ++ +K + E++ +L
Sbjct: 113 LEKYQG--LQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLAT 170
Query: 286 EIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDL--RKQLEHLQLLKLEA 343
EI + + EE+ + +++ + ++ Q+L +L R +E + +LK E
Sbjct: 171 EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKEL 230
Query: 344 EQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSL 403
Q + +M L+ R RESE +LK + + L+ Q I L + AK
Sbjct: 231 VQVQTLMDNMTLE----RERESE------KLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 404 FSTA-FSESLAAEISSVS-----RDELMEAIQKQEEINFRLQD 440
A + + L SSV+ L E + K+E+ +L++
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Score = 39.7 bits (91), Expect = 0.006
Identities = 52/253 (20%), Positives = 110/253 (43%), Gaps = 31/253 (12%)
Query: 146 LTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRA 205
L E L+ P E + ++++ ++ LE E+++ ++ +L+ +
Sbjct: 210 LKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATI 269
Query: 206 NALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQ---QLDEENSEL 262
+ L +L + V +E ++ K + ++ ++ ENL + Q +L+E+++E
Sbjct: 270 SQLRSELAKGPQEVAVYV-QELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE- 327
Query: 263 RSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEAT 322
K NI+ +K +++S RLS + + R+ LS + EAT
Sbjct: 328 ---ESVSKKNIQATLHQKDLDCQQLQS---RLSASETSLHRIHVELSEKG-------EAT 374
Query: 323 QELIEDLRK---QLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNR 379
Q+L E+L + + +HL+ + +Q+R GLQ L+ E+ +L
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQ----------LQSEINQLHSKLL 424
Query: 380 NLKEQNEELNGQI 392
+ Q E +G++
Sbjct: 425 ETERQLGEAHGRL 437
Score = 37.4 bits (85), Expect = 0.029
Identities = 62/316 (19%), Positives = 122/316 (38%), Gaps = 30/316 (9%)
Query: 132 SSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQH 191
+SK +Q G + LE EL + + + + + LEK+ A+ +
Sbjct: 871 NSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLK 930
Query: 192 SRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTR 251
L QL+ N L++ KE++ + + E ++ E +K +IE LQ
Sbjct: 931 LELNSMQEQLIQAQNTLKQNEKEEQ--QLQGNINELKQSSE-------QKKKQIEALQGE 981
Query: 252 LQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHE 311
L+ + +EL + +L+++ + E+ + ++S Q N + +
Sbjct: 982 LKIAVLQKTELEN----------KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1031
Query: 312 RHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEV 371
+ F + +DL+ E L L + + R + + + ++ LEQ+
Sbjct: 1032 QSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS 1091
Query: 372 RRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAF--SESLAAEISSVSRDELMEAIQ 429
+ +Q L+E+ + L IQ KSL +S AEI + + E +
Sbjct: 1092 AKKEQ---QLQERCKALQ------DIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITK 1142
Query: 430 KQEEINFRLQDYIDRI 445
EE+ + I I
Sbjct: 1143 LNEELKSHKLESIKEI 1158
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 67.0 bits (162), Expect = 3e-11
Identities = 91/344 (26%), Positives = 146/344 (42%), Gaps = 53/344 (15%)
Query: 157 ELM--EGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKE 214
ELM E P D V L+R +L+K T E S ++E Q H + L+E
Sbjct: 156 ELMSKESPVSAGNDAYVDLDR---QLKKTTEELNEALSA-KEEIAQRCHELDMQVAALQE 211
Query: 215 QE--LRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKAN 272
++ L A VL E Q + + LQT+L+QL EE L + +
Sbjct: 212 EKSSLLAENQVLMERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIR 271
Query: 273 IERLEEEKQKLLDEIESLTLRLSEEQENK------RRMGDRLSHERHQFQRDKEATQELI 326
E LE+E +L + + LT E Q K R D++S Q + K+ ++L
Sbjct: 272 CEELEKEISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDL- 330
Query: 327 EDLRKQLEHLQ---------LLKLEAEQRRGRSSSMGLQEY------------------- 358
DLR+Q++ L+ + LE E R+ ++ L+ Y
Sbjct: 331 GDLRRQVKLLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKAD 390
Query: 359 -----HSRARE--SELEQEVRRLKQDNRNLKEQNEEL---NGQIITLSIQGAKSLFSTAF 408
+ R +E L++E RL+ + +LKE EEL Q L+ QG L S
Sbjct: 391 KLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQES 450
Query: 409 SESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMET 452
S+SLAAEI + E + +Q + ++ Q+ D +A++++
Sbjct: 451 SDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIALLQS 494
Score = 53.9 bits (128), Expect = 3e-07
Identities = 92/369 (24%), Positives = 154/369 (41%), Gaps = 73/369 (19%)
Query: 134 KKVARYLHQSGALTMEALEDPSPELMEGPEEDI----ADKVVFLERRVLELEKDTAATGE 189
K+++ Q+ LT L D + L + E D+ +DKV LE +V +K G+
Sbjct: 277 KEISELRQQNDELT--TLADEAQSLKD--EIDVLRHSSDKVSKLEGQVESYKKKLEDLGD 332
Query: 190 ---QHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIE 246
Q L ++N + +LEE+L++ A LE +RQ +
Sbjct: 333 LRRQVKLLEEKNTMYMQNTVSLEEELRKAN--AARSQLETYKRQ--------------VV 376
Query: 247 NLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLT-----LRLSEEQENK 301
LQ RL + ++ +L LK ++ L++EK +L E +SL LR + QE +
Sbjct: 377 ELQNRLSEESKKADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQ 436
Query: 302 RRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQ----LLKLEAEQRRGRSSSMGLQE 357
L Q D A + + ++R++L LQ +LKL E ++ LQ
Sbjct: 437 LTT-QGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIAL-LQS 494
Query: 358 YHSRA--RESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAE 415
A R++ELE E R + Q ++ Q EEL +L QG+K+ S + L
Sbjct: 495 LLDDANLRKNELETENRLVNQRLLEVQSQVEELQK---SLQDQGSKAEDSVLLKKKLEEH 551
Query: 416 I--------------------------SSVSRDELMEAIQKQEE----INFRLQDYIDRI 445
+ SS+ +EL EA++K+EE + R + Y+++
Sbjct: 552 LEKLHEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKA 611
Query: 446 IVAIMETNP 454
I +P
Sbjct: 612 KSVIRTLDP 620
Score = 38.5 bits (88), Expect = 0.013
Identities = 61/265 (23%), Positives = 112/265 (42%), Gaps = 38/265 (14%)
Query: 128 TKRLSSKKVARYLH----QSGALTMEAL------EDPSPELMEGPEEDIADKVVFLERRV 177
T+R S K+ L Q G LT + L E E +I +K++ L+
Sbjct: 415 TERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEIVTPEIREKLIRLQHEN 474
Query: 178 LELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKM 237
L+ + + + L Q L+ AN + +L E E R L E + Q E L K
Sbjct: 475 KMLKLNQEGSDNEKIALLQS---LLDDANLRKNEL-ETENRLVNQRLLEVQSQVEELQKS 530
Query: 238 EREKSIEIEN-------LQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESL 290
+++ + E+ L+ L++L E N+EL+ +A IE LE +
Sbjct: 531 LQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQK----KRAIIEDLE-------PRFNNS 579
Query: 291 TLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDL-----RKQLEHLQLLKLEAEQ 345
+L++ E QE R+ + + ++++ E + +I L + +Q LK + ++
Sbjct: 580 SLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALKNQLQE 639
Query: 346 RRGRSSSMGLQEYHSRARESELEQE 370
R S+ +EY + E+E++
Sbjct: 640 RDRLFHSLE-KEYEKTKSQREMEEK 663
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 66.6 bits (161), Expect = 4e-11
Identities = 58/233 (24%), Positives = 104/233 (44%), Gaps = 21/233 (9%)
Query: 157 ELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQE 216
+L EE+ ++ + LE E ++ EQ R QE + EE+ +Q
Sbjct: 475 QLKRDQEEERRERWLKLEE---EERREQQERREQQLRREQEERREQRLKRQEEEERLQQR 531
Query: 217 LRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERL 276
LR+ + + E ++E L K E EK +E E + RL++ EE + ++R
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL---------LKRE 582
Query: 277 EEEKQKLL--DEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLE 334
EE +Q+ L ++ E L RL E+ + +R + + ++E Q+L++ ++
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 335 HLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEE 387
Q L+ E ++RR Q E LEQ ++R ++ R +E EE
Sbjct: 643 RQQQLRREQQERRE-------QRLKREEEEERLEQRLKREHEEERREQELAEE 688
Score = 63.2 bits (152), Expect = 5e-10
Identities = 74/244 (30%), Positives = 111/244 (45%), Gaps = 29/244 (11%)
Query: 156 PELMEGPEEDI-ADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKE 214
P L E E + A++ E+R L E++ Q R R++ LQ + EEQL+
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQR-REREKELQFLEE----EEQLQR 842
Query: 215 QELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIE 274
+E RA ++ EE Q++ ER +S E Q QL+EE R A E
Sbjct: 843 RE-RAQQLQEEEDGLQED----QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQE 897
Query: 275 RLEEEKQKLLDEIESL-----TLRLSEEQENKRRMGDRLSHERHQF---QRDKEATQELI 326
+L +E+Q L +E E L R +EQE + R ++L E Q +R+K QE
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERE 957
Query: 327 EDLRK----QLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLK 382
RK Q + QLL E E+RR + +E E EL+QE +L ++ R +
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE------EEELQQEEEQLLREEREKR 1011
Query: 383 EQNE 386
+ E
Sbjct: 1012 RRQE 1015
Score = 62.0 bits (149), Expect = 1e-09
Identities = 69/262 (26%), Positives = 122/262 (46%), Gaps = 43/262 (16%)
Query: 142 QSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQL 201
+ G + ++ EL EG E+ ++K LE+R D E+ R RQE +
Sbjct: 132 EPGQRRRQKRQEQERELAEGEEQ--SEKQERLEQR------DRQRRDEELWRQRQEWQER 183
Query: 202 VHRANALEEQLKEQELRAC------EMVLEETRRQKELL---CKMEREKSIEIENLQTRL 252
R + +E++L++C E EE R++ELL K EK + Q R+
Sbjct: 184 EER------RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRV 237
Query: 253 QQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHER 312
Q +EE E R L+ E+L+EE+ + E++ EE+E R++ ER
Sbjct: 238 FQ-EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ-------EEEEQLRKL------ER 283
Query: 313 HQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVR 372
+ +R+++ ++ + LR++ QL + + E+RR + Q+ +E EQ++R
Sbjct: 284 QELRRERQEEEQQQQRLRREQ---QLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 373 RLKQDNRN---LKEQNEELNGQ 391
R +++ R +EQ EE Q
Sbjct: 341 REQEERREQQLRREQEEERREQ 362
Score = 60.1 bits (144), Expect = 4e-09
Identities = 59/226 (26%), Positives = 109/226 (48%), Gaps = 30/226 (13%)
Query: 164 EDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMV 223
E+ D+ R +LEL + +Q R RQ+ + ++ +E+E R E V
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF---------QEEEEKEWRKRETV 252
Query: 224 LEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQ-- 281
L R+++E L + E ++ E++ + +L++L E ELR ER EEE+Q
Sbjct: 253 L---RKEEEKLQEEEPQRQRELQEEEEQLRKL--ERQELRR---------ERQEEEQQQQ 298
Query: 282 KLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKL 341
+L E + LR +E+E + + +R + + Q+++ Q+L + ++ E Q L+
Sbjct: 299 RLRREQQ---LRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE--QQLRR 353
Query: 342 EAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEE 387
E E+ R QE R ++ EQ++RR +Q R + + E+
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Score = 60.1 bits (144), Expect = 4e-09
Identities = 71/231 (30%), Positives = 104/231 (45%), Gaps = 32/231 (13%)
Query: 172 FLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQK 231
+ E L+ E++ E+ R RQE + + L++ KE++L E E+ RRQ
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ--KEEQLLGEEP--EKRRRQ- 984
Query: 232 ELLCKMEREKSI-EIENLQTRLQQLDEENSELRSCTPC---LKANIERLEEEKQKLLDEI 287
EREK E E LQ +QL E E R + E +EE+Q L +E
Sbjct: 985 ------EREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREER 1038
Query: 288 ESLTLRLSEEQENKRRMGDRLSHERHQF---QRDKEATQELIEDLRK----QLEHLQLLK 340
E L +E+E + R + L E Q +R+ QEL RK Q E QLL+
Sbjct: 1039 EKRRL---QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 341 LEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQ 391
E E+RR + +E E EL+QE +L ++ R K + +EL Q
Sbjct: 1096 EEPEKRRRQERERQCRE------EEELQQEEEQLLREERE-KRRRQELERQ 1139
Score = 59.7 bits (143), Expect = 5e-09
Identities = 60/246 (24%), Positives = 105/246 (42%), Gaps = 10/246 (4%)
Query: 146 LTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRA 205
L E E+ + E+ + K R E ++ EQ R++ L+
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 206 NALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSC 265
++ +EQE E L + ++ ++ RE+ + E R QQL E R
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 266 TPCLKANIERLEE--EKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQ 323
+ + R ++ +Q+L E E EQE + + R ER + + +E T+
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465
Query: 324 ELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNR--NL 381
++ RKQ QL + + E+RR R + L+E R ++ EQ++RR +++ R L
Sbjct: 466 RHEQERRKQ----QLKRDQEEERRER--WLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 382 KEQNEE 387
K Q EE
Sbjct: 520 KRQEEE 525
Score = 59.3 bits (142), Expect = 7e-09
Identities = 49/223 (21%), Positives = 108/223 (48%), Gaps = 16/223 (7%)
Query: 171 VFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQ 230
VF E E K ++ +L++E Q EEQL++ E + +E +Q
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ 296
Query: 231 KELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLL--DEIE 288
++ ++ RE+ + + + R +Q +E + + E+ EE +++ L ++ E
Sbjct: 297 QQ---RLRREQQLRRKQEEERREQQEERREQ--------QERREQQEERREQQLRREQEE 345
Query: 289 SLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRG 348
+L EQE +RR +L E+ + +R+++ +E + LR++ + + +L EQ+
Sbjct: 346 RREQQLRREQEEERR-EQQLRREQEEERREQQLRRE--QQLRREQQLRREQQLRREQQLR 402
Query: 349 RSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQ 391
R + ++ R ++ EQ++RR +++ R+ ++ +E Q
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Score = 57.4 bits (137), Expect = 3e-08
Identities = 56/215 (26%), Positives = 98/215 (45%), Gaps = 23/215 (10%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
E+++L+ E++ E+ R RQE R EEQL+++E + E+ RRQ+
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQ----ERQYREEEQLQQEEEQLLREEREKRRRQER- 956
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
ER+ + + Q Q L EE + R + E+ E+++L E E L
Sbjct: 957 ----ERQYRKDKKLQQKEEQLLGEEPEKRR------RQEREKKYREEEELQQEEEQL--- 1003
Query: 294 LSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSM 353
L EE+E +RR Q+++ E QE + LR++ E +L + E + R
Sbjct: 1004 LREEREKRRR-----QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Query: 354 GLQEYHSRARESELEQEVRRLKQDNRNLKEQNEEL 388
++ RE+ QE+ R + L+++ E+L
Sbjct: 1059 EEEQLLGEERETRRRQELERQYRKEEELQQEEEQL 1093
Score = 56.2 bits (134), Expect = 6e-08
Identities = 67/250 (26%), Positives = 115/250 (46%), Gaps = 37/250 (14%)
Query: 149 EALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANAL 208
E L++ P+ +E+ +++ LER+ EL ++ +Q RLR+E Q + R
Sbjct: 258 EKLQEEEPQRQRELQEE-EEQLRKLERQ--ELRRERQEEEQQQQRLRRE--QQLRRKQ-- 310
Query: 209 EEQLKEQELRACEMVLEETRRQKELLCKME--REKSIEIENLQTRLQQLDEENSELRSCT 266
EE+ +EQ+ EE R Q+E + E RE+ + E + R QQL E E
Sbjct: 311 EEERREQQ--------EERREQQERREQQEERREQQLRREQEERREQQLRREQEE----- 357
Query: 267 PCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELI 326
ER E++ ++ +E E +L EQ+ +R ++ Q +R+++ +E
Sbjct: 358 -------ERREQQLRREQEE-ERREQQLRREQQLRR---EQQLRREQQLRREQQLRREQQ 406
Query: 327 EDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESEL--EQEVRR--LKQDNRNLK 382
+QL Q L+ E + RR + Q++ RE L EQE RR LK++ +
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466
Query: 383 EQNEELNGQI 392
+ E Q+
Sbjct: 467 HEQERRKQQL 476
Score = 56.2 bits (134), Expect = 6e-08
Identities = 52/221 (23%), Positives = 100/221 (45%), Gaps = 13/221 (5%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
E+++ E+D E+ RQE + Q + ++ R E +L+E R+++
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE--REEQQ 1477
Query: 234 LCKMEREKSIEIENLQTRLQQLDEE--NSELRSCTPCLKANIERLEEEKQKLLDEIESLT 291
L + ER++ E Q R Q+ D + ELRS P K LEEE+Q + +
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF----LEEEQQLHRQQRQRKF 1533
Query: 292 LRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSS 351
L+ ++ + R R +F+ +++ QE E + E + +LE ++ R +
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593
Query: 352 SMGLQEYHSRARESELEQEV-----RRLKQDNRNLKEQNEE 387
E + R E +Q++ R+ ++D + L+E+ E+
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Score = 55.8 bits (133), Expect = 8e-08
Identities = 55/202 (27%), Positives = 96/202 (47%), Gaps = 22/202 (10%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
ERR L+++ EQ RL++E ++ + + E++LK +E EE RRQ+ L
Sbjct: 584 ERRQQRLKREQEERLEQ--RLKREEVERLEQEERREQRLKREEP-------EEERRQQLL 634
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
+ + E+ R QQL E E R + ERLE+ ++ +E E
Sbjct: 635 KSEEQEER---------RQQQLRREQQERREQRLKREEEEERLEQRLKREHEE-ERREQE 684
Query: 294 LSEEQEN--KRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSS 351
L+EE++ + R+ R+ + Q + + +A Q + ++ E + + + E+RR R S
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 352 SMGLQEYHSRARESELEQEVRR 373
+ QE RA + E+E RR
Sbjct: 745 ELQWQE-EERAHRQQQEEEQRR 765
Score = 55.8 bits (133), Expect = 8e-08
Identities = 74/277 (26%), Positives = 117/277 (42%), Gaps = 43/277 (15%)
Query: 129 KRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATG 188
+R +K ++L + L E +G +ED ERR + ++
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED-------QERRRSQEQRRDQKWR 875
Query: 189 EQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEE-----TRRQKELLCKMEREKSI 243
Q R+ ++ AL+EQL++++ +L+E R ++E + E+E+
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQ-----QLLQEEEEELQREEREKRRRQEQERQY 930
Query: 244 -EIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESL-----TLRLSEE 297
E E LQ +QL E E R + ER + +KL + E L R +E
Sbjct: 931 REEEQLQQEEEQLLREEREKRR-----RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Query: 298 QENKRRMGDRLSHERHQF---QRDKEATQELIEDLRK----QLEHLQLLKLEAEQRRGRS 350
+E K R + L E Q +R+K QE RK Q E QLL+ E E+RR
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR--- 1042
Query: 351 SSMGLQEYHSRAR-ESELEQEVRRLKQDNRNLKEQNE 386
LQE + R E EL+QE +L + R + + E
Sbjct: 1043 ----LQERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Score = 55.5 bits (132), Expect = 1e-07
Identities = 64/266 (24%), Positives = 114/266 (42%), Gaps = 57/266 (21%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMV-------LEE 226
ERR +L ++ EQ + ++E +L R + ++ +EQE R +++ LE+
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 227 TRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEE------- 279
RR++ L + E + ++ + R QQ + E R + +ERLE+E
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 280 KQKLLDEIESLTLRLSEEQENKR-----------------------RMGDRLSHERHQFQ 316
K++ +E L SEEQE +R R+ RL E + +
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 317 RDKEATQELIEDLRKQLEHL-----QLLKLEAEQRRGRSSSMGL----------QEYHSR 361
R++E +E E R++++ L+ EA+ R+ + S QE R
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 362 ARESELEQEVRRLKQDNRNLKEQNEE 387
RESEL+ + ++ R ++Q EE
Sbjct: 741 RRESELQWQ-----EEERAHRQQQEE 761
Score = 54.3 bits (129), Expect = 2e-07
Identities = 74/255 (29%), Positives = 108/255 (42%), Gaps = 36/255 (14%)
Query: 158 LMEGPEEDIADKVVFLER-RVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQE 216
L EG E+ + + ER R E+ E+ + QE QL R LE + +E+E
Sbjct: 1676 LQEGEEQQLRRQ----ERDRKFREEEQQLRRQERERKFLQEEQQL--RRQELERKFREEE 1729
Query: 217 LRACEMVLEETRRQKELLCKMEREK-SIEIENLQTRLQQLDE------------ENSELR 263
E E+ RRQ+ +E E+ E E Q R Q+ D E +LR
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789
Query: 264 SCTPCLKANIE---RLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKE 320
S K E R E E+Q+L + R EEQ RL ER + R +E
Sbjct: 1790 SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849
Query: 321 --ATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDN 378
ATQE K Q L E EQ+R + L+E H R ++ E EQ R++ +
Sbjct: 1850 QFATQE------KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE-EQRHRQVGE-- 1900
Query: 379 RNLKEQNEELNGQII 393
+K Q + +G+++
Sbjct: 1901 --IKSQEGKGHGRLL 1913
Score = 53.9 bits (128), Expect = 3e-07
Identities = 69/281 (24%), Positives = 118/281 (41%), Gaps = 48/281 (17%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
ERR +L ++ EQ R R++ L+ + ++ +EQ+LR ++ RR+++L
Sbjct: 371 ERREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQLRR----EQQLRREQQL 425
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKL---------- 283
+ E E+ + + R Q+L E E R + ER E+E++K
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLK-REEETERHEQERRKQQLKRDQEEER 484
Query: 284 ------LDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQ 337
L+E E + EQ+ +R E + QR K +E E L+++L Q
Sbjct: 485 RERWLKLEEEERREQQERREQQLRR------EQEERREQRLKRQEEE--ERLQQRLRSEQ 536
Query: 338 LLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSI 397
L+ E E+RR ++ R E LEQE R + LK + EE Q++
Sbjct: 537 QLRREQEERR--------EQLLKREEEKRLEQERR-----EQRLKREQEERRDQLLKREE 583
Query: 398 QGAKSLFSTAFSESL-----AAEISSVSRDELMEAIQKQEE 433
+ + E L E+ + ++E E K+EE
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Score = 53.9 bits (128), Expect = 3e-07
Identities = 62/237 (26%), Positives = 105/237 (44%), Gaps = 23/237 (9%)
Query: 172 FLERRVLELEKDTAATGEQHSRLRQENLQLVHRANAL---EEQLKEQELRACEMVLEETR 228
+ E ++ E++ E R RQE + L EEQL +E E
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 229 RQKELLCKMEREKSIEIENLQTRLQ---QLDEENSELRSCTPCLKANIERLEEEKQKLLD 285
R++E L + +R++ E+ ++ L+ + ++EN+ + C E+ + + L
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259
Query: 286 EIES---LTLRLSEEQEN-----KRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQ 337
+ +S L L E+QE +RR R H + Q ++E +E RK E Q
Sbjct: 1260 DRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 338 LLKLEAEQRRGRSSSMGLQEYHSRARESE---LEQEVRRLKQDNRNLKEQNEELNGQ 391
LL+ E E++R R QE + RE E E+E + L++ R+ K + EEL Q
Sbjct: 1320 LLREEREEKRRR------QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Score = 53.5 bits (127), Expect = 4e-07
Identities = 69/250 (27%), Positives = 117/250 (46%), Gaps = 35/250 (14%)
Query: 157 ELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQE 216
+L EE+ ++ ERR L+++ E+ L++E H ++QLK +
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQE---ERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 217 LRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERL 276
EE RR++ L K+E E+ E + + R QQL E E R + ERL
Sbjct: 481 --------EEERRERWL--KLEEEERREQQ--ERREQQLRREQEERREQRLKRQEEEERL 528
Query: 277 EEE---KQKLLDEIESLTLRLSEEQENKR----RMGDRLSHERHQ-----FQRDKEATQE 324
++ +Q+L E E +L + +E KR R RL E+ + +R++E Q+
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ 588
Query: 325 LI-----EDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRAR--ESELEQEVRRLKQD 377
+ E L ++L+ ++ +LE E+RR + E R + +SE EQE RR +Q
Sbjct: 589 RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE-EQEERRQQQL 647
Query: 378 NRNLKEQNEE 387
R +E+ E+
Sbjct: 648 RREQQERREQ 657
Score = 53.5 bits (127), Expect = 4e-07
Identities = 71/275 (25%), Positives = 119/275 (43%), Gaps = 46/275 (16%)
Query: 123 LTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEK 182
L P KR ++ +Y + E L+ +L+ E +RR E E+
Sbjct: 974 LGEEPEKRRRQEREKKYREE------EELQQEEEQLLREERE---------KRRRQEWER 1018
Query: 183 DTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMERE-- 240
E L+QE QL+ R + +L+E+E + E EE ++++E L ERE
Sbjct: 1019 QYRKKDE----LQQEEEQLL-REEREKRRLQERERQYREE--EELQQEEEQLLGEERETR 1071
Query: 241 KSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEE--EKQKLLDEIESLTLRLSEEQ 298
+ E+E + ++L +E +L P + ER + E+++L E E L L EE+
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL---LREER 1128
Query: 299 ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY 358
E +RR +E ++ E+ Q E QLL+ E E+RR + +E
Sbjct: 1129 EKRRR---------------QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 359 HSRARESE--LEQEVRRLKQDNRNLKEQNEELNGQ 391
+E E L +E + +Q+ + EEL Q
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQ 1208
Score = 52.8 bits (125), Expect = 7e-07
Identities = 48/220 (21%), Positives = 99/220 (45%), Gaps = 25/220 (11%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
ER+ LE E+ Q L++E Q ++++ R E + +E R+++
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQE--REEQQ 1571
Query: 234 LCKMEREKSIEIENLQTRLQQLD----EENSELRSCTPCLKANIERLEEEKQKLLDEIES 289
L + ER++ +E + R Q+ + E+ +LR + ++L +E+ + E E
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR-----QEGQQQLRQERDRKFREDEQ 1626
Query: 290 LTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQ---R 346
L E+Q +++ + E Q +R ++ +QL H + K E+ +
Sbjct: 1627 LLQEREEQQLHRQERDRKFLEEEPQLRR---------QEREQQLRHDRDRKFREEEQLLQ 1677
Query: 347 RGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNE 386
G + QE + RE EQ++RR +++ + L+E+ +
Sbjct: 1678 EGEEQQLRRQERDRKFREE--EQQLRRQERERKFLQEEQQ 1715
Score = 52.4 bits (124), Expect = 9e-07
Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 25/215 (11%)
Query: 189 EQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENL 248
EQ R ++ + + L Q +EQ+LR + R +++ L + ER++ E
Sbjct: 1380 EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD--RKFREEEQQLSRQERDRKFREEEQ 1437
Query: 249 QTRLQQLD----EENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSE------EQ 298
Q R Q+ + EE +LR R E+++LL E E L E E+
Sbjct: 1438 QVRRQERERKFLEEEQQLRQ-------ERHRKFREEEQLLQEREEQQLHRQERDRKFLEE 1490
Query: 299 ENKRRMGDRLSHERHQFQRDKEATQELIED---LRKQLEHLQLLKLEAEQRRGRSSSMGL 355
E + R +R R Q R +E ++ +E+ L +Q + L+ E + RR
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRR 1550
Query: 356 QEYHSRARESE---LEQEVRRLKQDNRNLKEQNEE 387
Q+ + RE E E+E ++L + R+ K + EE
Sbjct: 1551 QDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Score = 50.4 bits (119), Expect = 3e-06
Identities = 56/233 (24%), Positives = 103/233 (44%), Gaps = 23/233 (9%)
Query: 176 RVLELEKDTAATGEQHSRLRQENLQLVHRANALE-EQLKEQELRACEMVLEETRRQKELL 234
R LE+ EQ + ++ QL + + Q ++++ R E +L+E R+++ L
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE--REEQQL 1636
Query: 235 CKMEREKSIEIENLQTRLQQLDEE-----NSELRSCTPCLKANIE---RLEEEKQKLLDE 286
+ ER++ E Q R Q+ +++ + + R L+ E R +E +K +E
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREE 1696
Query: 287 IESLTLR------LSEEQENKRRMGDRLSHERHQFQRDKEATQ-ELIEDLRKQLEHLQLL 339
+ L + L EEQ+ +R+ +R E Q +++ E Q E RK LE QL
Sbjct: 1697 EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLR 1756
Query: 340 KLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNR-----NLKEQNEE 387
EQ+ R + R+ EQ++R + D + L+++ EE
Sbjct: 1757 PEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE 1809
Score = 50.4 bits (119), Expect = 3e-06
Identities = 63/249 (25%), Positives = 104/249 (41%), Gaps = 33/249 (13%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
+R+ LE E+ E+ +LR + + L ++ +EQ+LR E + R +++
Sbjct: 1642 DRKFLE-EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD-RKFREEEQQ 1699
Query: 234 LCKMEREKSIEIENLQTRLQQLDE---ENSELRSCTP------------CLKANIERLEE 278
L + ERE+ E Q R Q+L+ E +LR T L+ R E
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 279 EKQKLLDEIESLTLRLS-------EEQENKRRMGDRLSHERHQFQRDKE----ATQELIE 327
E+Q+L + R EEQ+ + + DR E Q ++++E Q+
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 328 DLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY-----HSRARESELEQEVRRLKQDNRNLK 382
R + E LQL + E R+ R +E SR E EL QE + ++ R K
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERK 1879
Query: 383 EQNEELNGQ 391
+ E + Q
Sbjct: 1880 LREEHIRRQ 1888
Score = 50.1 bits (118), Expect = 4e-06
Identities = 51/216 (23%), Positives = 94/216 (43%), Gaps = 21/216 (9%)
Query: 189 EQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENL 248
E R + QL Q ++++ R E++ +Q+ L + + + E+
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQ 176
Query: 249 QTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRR-MGDR 307
+ Q+ +E +E C E +E+Q E+ L + EE++ +RR DR
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR 236
Query: 308 LSHERHQ---------FQRDKEATQELIEDLRKQL--EHLQLLKLEAEQ-RRGRSSSMGL 355
+ E + ++++E QE +++L E QL KLE ++ RR R
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER------ 290
Query: 356 QEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQ 391
QE + + EQ++RR +++ R +EQ EE Q
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEER--REQQEERREQ 324
Score = 50.1 bits (118), Expect = 4e-06
Identities = 51/203 (25%), Positives = 86/203 (42%), Gaps = 16/203 (7%)
Query: 193 RLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRL 252
R RQ L H +E+ +EQE R + +++L + ++E Q
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 253 QQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR-------LSEEQENKRRMG 305
Q L EE E R + +R E+++LL E E LR EE+ + G
Sbjct: 1319 QLLREEREEKRR-----RQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373
Query: 306 DRLSHERHQFQRDKEATQELIED--LRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRAR 363
+ E + +R + + L E+ LR Q QL + + R + QE + R
Sbjct: 1374 RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 364 ESELEQEVRRLKQDNRNLKEQNE 386
E E Q+VRR +++ + L+E+ +
Sbjct: 1434 EEE--QQVRRQERERKFLEEEQQ 1454
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/221 (25%), Positives = 104/221 (47%), Gaps = 12/221 (5%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
E+ + E E+ E+ + +E QL R + + +EQELR+ E + +++L
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQL--RRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
+ +R++ E Q R Q+ ++ + R + + R E E+Q+L + R
Sbjct: 1525 H-RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL-RQEREEQQLSRQERDRKFR 1582
Query: 294 LSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDL-RKQLEHLQLLKLEAEQRRGRSS- 351
L EEQ+ +R+ +R E Q R +E Q+L ++ RK E QLL+ EQ+ R
Sbjct: 1583 L-EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 352 SMGLQEYHSRARESELEQEV-----RRLKQDNRNLKEQNEE 387
E + R E EQ++ R+ +++ + L+E E+
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ 1682
Score = 42.7 bits (99), Expect = 7e-04
Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 27/210 (12%)
Query: 189 EQHSRLRQENLQLVHRANALEEQLKEQELRACE---MVLEETRRQKELLC-----KMERE 240
E+ R R+ LQ A +Q +E++ R E++ R ++ L + +RE
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 241 KSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQEN 300
+ + E Q R Q+ E E K R E++K L +E EE++
Sbjct: 796 RQLRAEERQQREQRFLPEEEE--------KEQRRRQRREREKELQFLE-------EEEQL 840
Query: 301 KRR-MGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYH 359
+RR +L E Q D+E + E R Q QL + +R + LQE
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQ-EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 360 SRARE--SELEQEVRRLKQDNRNLKEQNEE 387
+ ++ E E+E++R +++ R +EQ +
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Score = 42.7 bits (99), Expect = 7e-04
Identities = 68/271 (25%), Positives = 112/271 (41%), Gaps = 41/271 (15%)
Query: 149 EALEDPSPELMEGPEEDIADKVV--FLERRVLELEKDTAATGEQHSRLRQENLQLVHRAN 206
E ++ L E PE+ ++ + E L+ E++ EQ R RQE +
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR-RQERERQYREEE 1203
Query: 207 ALEEQLKEQELR----------ACEMVLEETRRQKELLCK-MEREKSIEIENLQTRLQQL 255
L+ Q ++Q R E E R ++ CK E E+ ++E+ Q R +Q
Sbjct: 1204 ELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQS 1263
Query: 256 DEENSELRSCTPCLKANIERLEEEKQKLLDEI-----ESLTLRLSEEQENKRRMGDRLSH 310
++ L L ER E++++ + E L E++E KRR DR S
Sbjct: 1264 QQDLQHL------LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR--DRKSQ 1315
Query: 311 ERHQFQRD-KEATQELIEDLRKQLEHLQLLKLEAEQ--------RRGRSSSMGLQEYHSR 361
E Q R+ +E + E RK E QLL+ EQ R+ R + QE +
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 362 ARESEL-----EQEVRRLKQDNRNLKEQNEE 387
E E E+E + LK++ + ++ E+
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQ 1406
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 65.9 bits (159), Expect = 8e-11
Identities = 73/288 (25%), Positives = 130/288 (45%), Gaps = 30/288 (10%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKME 238
+LE++ A G+Q ++ Q + +EQ Q+ R + + E ++E L +
Sbjct: 755 QLEREKEALGQQERERARQRFQ----QHLEQEQWALQQQR--QRLYSEVAEERERLGQQA 808
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ 298
+ E+E L+ QQL+E +S L T L+A E+ EE+++ ++E TL+ E
Sbjct: 809 ARQRAELEELR---QQLEESSSAL---TRALRAEFEKGREEQERR-HQMELNTLKQQLEL 861
Query: 299 ENKR-RMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQE 357
E + G E R++E +E+ + K++E L + +LEA+ + S E
Sbjct: 862 ERQAWEAGRTRKEEAWLLNREQELREEIRKGRDKEIE-LVIHRLEADMALAKEESEKAAE 920
Query: 358 YHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI-----ITLSIQGAKSLFSTAFSESL 412
+ + E E+ L+Q R L+E+ EL GQ+ L +QG A ++
Sbjct: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQ 980
Query: 413 AA-EISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEV 459
A E S R L + I+ Q++ DR+ + ET + E+
Sbjct: 981 AVNEQLSSERSNLAQVIR---------QEFEDRLAASEEETRQAKAEL 1019
Score = 49.7 bits (117), Expect = 6e-06
Identities = 64/255 (25%), Positives = 112/255 (43%), Gaps = 35/255 (13%)
Query: 129 KRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLE--RRVLELEKDTAA 186
+R +++ + L +S + AL E +G EE + L ++ LELE+
Sbjct: 811 QRAELEELRQQLEESSSALTRALR---AEFEKGREEQERRHQMELNTLKQQLELERQAWE 867
Query: 187 TGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIE 246
G R R+E L++R L E++++ + E+V+ L K E EK+ E
Sbjct: 868 AG----RTRKEEAWLLNREQELREEIRKGRDKEIELVIHRLEADM-ALAKEESEKAAE-- 920
Query: 247 NLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSE-EQENKRRMG 305
+R+++L ++ +A + LE+ ++KL + L +L E E EN R G
Sbjct: 921 ---SRIKRLRDK----------YEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQG 967
Query: 306 DRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRA--- 362
L ++ + D +A E + R L Q+++ E E R S Q A
Sbjct: 968 --LVRQKERALEDAQAVNEQLSSERSNL--AQVIRQEFEDRLAASEEETRQAKAELATLQ 1023
Query: 363 --RESELEQEVRRLK 375
++ ELE+ RR+K
Sbjct: 1024 ARQQLELEEVHRRVK 1038
Score = 45.1 bits (105), Expect = 1e-04
Identities = 65/275 (23%), Positives = 106/275 (38%), Gaps = 43/275 (15%)
Query: 156 PELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQ 215
PE GP E ++ + R LE+E+ A L Q+ R E+ L Q
Sbjct: 553 PEAGPGPLELGSEVSTSVMRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQ 612
Query: 216 ELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEEN---------------- 259
R E +R + ++ +K + E + + +L +E+
Sbjct: 613 LQRQREHYEATIQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHEL 672
Query: 260 -----SELRSCTPCLKANIERLEEEKQKLLDEIESLTLR------LSEEQENKRRMGDRL 308
EL S T KA E+ EK K + E+ L ++ ++ RR+ +
Sbjct: 673 EIKKLKELMSATE--KARREKWISEKTKKIKEVTVRGLEPEIQKLIARHKQEVRRL--KS 728
Query: 309 SHERHQFQRDKEATQELI---EDLRKQLEHLQLLKLEAEQRRGR--------SSSMGLQE 357
HE Q D+ A+Q + E+LR+QLE + + E+ R R LQ+
Sbjct: 729 LHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRFQQHLEQEQWALQQ 788
Query: 358 YHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI 392
R SE+ +E RL Q + + EEL Q+
Sbjct: 789 QRQRL-YSEVAEERERLGQQAARQRAELEELRQQL 822
Score = 34.3 bits (77), Expect = 0.24
Identities = 44/160 (27%), Positives = 67/160 (41%), Gaps = 20/160 (12%)
Query: 126 SPTKRLSSKKVARY--LHQSGALTMEALEDPSPELMEGPEEDIA-DKVVFLERRVLELEK 182
S KRL K A L QS E + +L E E++ +V + R LE
Sbjct: 921 SRIKRLRDKYEAELSELEQSERKLQERCSELKGQLGEAEGENLRLQGLVRQKERALE--- 977
Query: 183 DTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKS 242
D A EQ S R Q++ + E++L E EETR+ K L ++ +
Sbjct: 978 DAQAVNEQLSSERSNLAQVIRQE--FEDRLAASE--------EETRQAKAELATLQARQQ 1027
Query: 243 IEIE----NLQTRLQQLDEENSELRSCTPCLKANIERLEE 278
+E+E ++T L + +E S LR+ + LEE
Sbjct: 1028 LELEEVHRRVKTALARKEEAVSSLRTQHEAAVKRADHLEE 1067
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 65.1 bits (157), Expect = 1e-10
Identities = 63/265 (23%), Positives = 122/265 (46%), Gaps = 36/265 (13%)
Query: 160 EGPEEDIADKVVFLERRVLELEKDTAATGEQ---------------HSRLRQ---ENLQL 201
E +D+A ++ + +R+ ELE+ A Q H RL+Q E L
Sbjct: 152 EEESKDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQTIKERALL 211
Query: 202 VHRANALEEQLKEQELRACEM---VLEETRRQKELLCKMERE-KSIEIENLQT--RLQQL 255
+ E LK+ +L E + E R +E + KM E ++++ E + R+Q+L
Sbjct: 212 NAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQEL 271
Query: 256 DEENSELRS--------CTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDR 307
+ SEL++ P + + +E+L++E + L E+E L +L + EN + +
Sbjct: 272 ERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLL 331
Query: 308 LSHERHQFQRDKEATQEL-IEDLRKQ---LEHLQLLKLEAEQRRGRSSSMGLQEYHSRAR 363
++ + Q +E +E ++ +R+Q E + L+ + + + + + QE R +
Sbjct: 332 SKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQ 391
Query: 364 ESELEQEVRRLKQDNRNLKEQNEEL 388
E L +E RL++ + L +Q E L
Sbjct: 392 EERLRKEEERLQKQEKRLWDQEERL 416
Score = 55.5 bits (132), Expect = 1e-07
Identities = 63/273 (23%), Positives = 120/273 (43%), Gaps = 28/273 (10%)
Query: 178 LELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKM 237
++LE+D A + R R + + + + + LKE++ R + E R EL +M
Sbjct: 225 VQLERDEYAKHIKGERARWQ--ERMWKMSVEARTLKEEKKRDIHRIQELERSLSELKNQM 282
Query: 238 EREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERL-----------EEEKQKLLDE 286
+ S+ + + ++QL +E LR L+ ++ +E+KQ+L ++
Sbjct: 283 AKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQ 342
Query: 287 IESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQR 346
E L E++ + R +RL + + + ++ QE E LRKQ + +L ++
Sbjct: 343 EE----MLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQ-----RLRKQEE 393
Query: 347 RGRSSSMGLQEYHSRARESE---LEQEVRRLKQDNRNLKEQNEELNGQII--TLSIQGAK 401
R R LQ+ R + E ++E R KQ+ R QN +L+ Q+ S +
Sbjct: 394 RLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLN 453
Query: 402 SLFSTAFS-ESLAAEISSVSRDELMEAIQKQEE 433
+ +A E E+ +E +EA +Q +
Sbjct: 454 NEKKSALQLEQQVKELQEKLDEEHLEAASQQNQ 486
Score = 55.1 bits (131), Expect = 1e-07
Identities = 50/231 (21%), Positives = 101/231 (43%), Gaps = 29/231 (12%)
Query: 155 SPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKE 214
+P + E + D+ L + V LE + E + L + + R EE L+E
Sbjct: 289 APPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLRE 348
Query: 215 QELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIE 274
QE++ R++E LC+ + + LQ + ++L ++ LR L+ E
Sbjct: 349 QEVQRV--------REQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQEERLRKEEE 400
Query: 275 RLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLS-HERHQFQRDKEATQELIEDLRKQL 333
RL++++++L D+ E RL +++E ++ +RL+ + H+ + Q EDL +
Sbjct: 401 RLQKQEKRLWDQEE----RLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNE- 455
Query: 334 EHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQ 384
+ S++ L++ +E E+ + Q N+ L+ Q
Sbjct: 456 ---------------KKSALQLEQQVKELQEKLDEEHLEAASQQNQQLETQ 491
Score = 36.2 bits (82), Expect = 0.064
Identities = 27/136 (19%), Positives = 62/136 (45%), Gaps = 7/136 (5%)
Query: 277 EEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL 336
+ + Q+L +ES ++ +S+ EN + + HQ + K+ E+ + ++LE +
Sbjct: 68 DSQYQELAVALESSSVTISQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMERLETI 127
Query: 337 QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLS 396
+L LE + + YH++ E+E + L + ++ +EL + +S
Sbjct: 128 NILTLE-------KADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALCAVS 180
Query: 397 IQGAKSLFSTAFSESL 412
Q + S++ E++
Sbjct: 181 TQQQEEDRSSSCREAV 196
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 64.7 bits (156), Expect = 2e-10
Identities = 84/317 (26%), Positives = 146/317 (46%), Gaps = 49/317 (15%)
Query: 159 MEGPEEDIADKVVFLERRVLELEKD-----TAATGEQHSRLRQENL--QLVHRANALEEQ 211
+E D+ DK LE L+LEK+ +A E+ R + L R LEE
Sbjct: 595 LESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEED 654
Query: 212 LKEQELRACEMVLEETRRQKELLCKMEREKS-IEIE---NLQTRLQQLDEENSELRSCTP 267
LK ++ ++ LE+ R+ +E +E+EKS +EI+ L+ Q L++E +E ++
Sbjct: 655 LKNGKILLAKVELEK-RQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKA 713
Query: 268 CLKAN---IERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQ---FQRDKEA 321
L E +EE K + + E+E +L EE+ K+++ + L + D +
Sbjct: 714 RLADKNKIYESIEEAKSEAMKEMEK---KLLEERTLKQKVENLLLEAEKRCSLLDCDLKQ 770
Query: 322 TQELIEDLRKQLEHLQ------LLKLEAEQRR----GRSSSMGLQEYHS-RARESELEQE 370
+Q+ I +L KQ + L LK+E E ++ M Q+ ++ + E +L+QE
Sbjct: 771 SQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQE 830
Query: 371 VRRLKQDNRNLKEQNEEL-------NGQIITLSIQ-GAKSLFSTAFSESLAAEISSVSRD 422
L + NL++QN EL +GQ+ L Q A+ FST + +
Sbjct: 831 NNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVR--------- 881
Query: 423 ELMEAIQKQEEINFRLQ 439
EL E +++ ++ LQ
Sbjct: 882 ELKEECEEKTKLGKELQ 898
Score = 53.9 bits (128), Expect = 3e-07
Identities = 58/279 (20%), Positives = 123/279 (44%), Gaps = 40/279 (14%)
Query: 149 EALEDPSPELMEGPEEDIADKVVF---LERRVLELEKDTAATGEQHSRLRQENLQLVHRA 205
E++E+ E M+ E+ + ++ +E +LE EK + + +Q+ +L+ +
Sbjct: 723 ESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQK 782
Query: 206 NALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSC 265
+ L E ++ L+ + + Q +L KM+ + ++ L+ +QL +EN+ L
Sbjct: 783 DVLNEDVRNLTLKIEQETQKRCLTQNDL--KMQTQ---QVNTLKMSEKQLKQENNHLMEM 837
Query: 266 TPCLKANIERLEEEKQ-------KLLDEIE----------SLTLRLSEEQENKRRMGDRL 308
L+ L +E+Q +L D++E + L EE E K ++G L
Sbjct: 838 KMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKEL 897
Query: 309 SHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAE------QRRGRSSSMGLQEYHSRA 362
++ + Q ++++ +E + + QL + AE ++ + ++E +R
Sbjct: 898 QQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARH 957
Query: 363 RE---------SELEQEVRRLKQDNRNLKEQNEELNGQI 392
++ + LE+ R L D NL + EELN ++
Sbjct: 958 KQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKL 996
Score = 46.6 bits (109), Expect = 5e-05
Identities = 50/239 (20%), Positives = 101/239 (42%), Gaps = 37/239 (15%)
Query: 154 PSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLK 213
P P+ G + + E +L T SR +E+ ++ + LEE L
Sbjct: 398 PIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLS 457
Query: 214 EQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANI 273
EM +E QK CK ++ TRL++ +E E + +++ +
Sbjct: 458 N------EMQAKEELEQK---CK----------SVNTRLEKTAKELEEEITLRKSVESAL 498
Query: 274 ERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQL 333
+LE EK L + + E + KR + + D + ++ +EDL+K+
Sbjct: 499 RQLEREKALLQHKNAEYQRKADHEADKKRNL-----------ENDVNSLKDQLEDLKKRN 547
Query: 334 EHLQLLKLEAEQ-RRGRSSSMGLQEYHS------RARESELEQEVRRLKQDNRNLKEQN 385
++ Q+ + Q +R + L S R ++E +++++L+ +NR+L+++N
Sbjct: 548 QNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKN 606
Score = 36.2 bits (82), Expect = 0.064
Identities = 58/297 (19%), Positives = 119/297 (40%), Gaps = 44/297 (14%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKE-QELRACEMVLEETRRQKELLCKM 237
+L+++ E L ++N +L + Q+KE Q+ E + + K
Sbjct: 826 QLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKE 885
Query: 238 EREKSIEI-ENLQTRLQQLDEENSELRSCTPCL--KANIERLEE----------EKQKLL 284
E E+ ++ + LQ + Q+L +E L + KA+ E+L EK+K++
Sbjct: 886 ECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIM 945
Query: 285 DEIESLTLRLSEEQE--------------NKRRMGD--RLSHERHQFQRDKEATQELIED 328
E+E + +QE N+ D L++E+ + + QE +
Sbjct: 946 KELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSR 1005
Query: 329 LRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQ--------EVRRLKQDNR- 379
L+ + +K + E++ ++ Q + A ++ +VRR +++NR
Sbjct: 1006 LKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRK 1065
Query: 380 ---NLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSV--SRDELMEAIQKQ 431
LK + E+L Q+I + + A + E+ S+D +E ++ Q
Sbjct: 1066 LHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQ 1122
Score = 35.0 bits (79), Expect = 0.14
Identities = 54/254 (21%), Positives = 110/254 (43%), Gaps = 39/254 (15%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELR------ACEMVLEE 226
LER L+ A + + L + N+L++QL++ + R + E V +
Sbjct: 501 LEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQL 560
Query: 227 TRRQKEL--LCKMEREKSIEIENLQT----RLQQLDEENSELRSCTPCLKANIERLEEE- 279
R+ E L + E + + + Q ++QQL+ N +L+ L+ +LE+E
Sbjct: 561 QRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEF 620
Query: 280 ----------------KQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQR---DKE 320
+++++++ L E+ +N + + ++ E+ Q Q D E
Sbjct: 621 INLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLE 680
Query: 321 ATQELIE-DLRKQLEHLQLLKLEAEQRRGRSSSMGLQE----YHS-RARESELEQEVRRL 374
+ +E D+ QL+ +Q LE E+ +++ L + Y S +SE +E+ +
Sbjct: 681 KEKSNMEIDMTYQLKVIQ-QSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKK 739
Query: 375 KQDNRNLKEQNEEL 388
+ R LK++ E L
Sbjct: 740 LLEERTLKQKVENL 753
>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
Length = 2649
Score = 64.3 bits (155), Expect = 2e-10
Identities = 67/303 (22%), Positives = 134/303 (44%), Gaps = 32/303 (10%)
Query: 129 KRLSSKKVARYLHQS--GALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAA 186
KRL +++ R S GA + + L+ ++E + + K+ LER V EL+K +
Sbjct: 1100 KRLEEEEIKRCKETSEHGAYS-DLLQRQKATVLENSK--LTGKISELERMVAELKKQKSR 1156
Query: 187 TGEQHSRLRQE---------------NLQLVHRANALEEQLKEQE--LRACEMVLEETRR 229
E+ ++R+ +LQ + + ++ +E E +R E E R
Sbjct: 1157 VEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAERELER 1216
Query: 230 QKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKA---NIERLEEEKQKLLDE 286
++L + E +++ ENL QL+E R+ LK ++ LE++K KL++E
Sbjct: 1217 VRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEE 1276
Query: 287 IESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLE---- 342
+ E + ++M L+ ++ ++ + Q++ + R+++ +Q E
Sbjct: 1277 LRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQYTCRENALP 1336
Query: 343 ---AEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQG 399
Q + GLQ+ H + + EL+Q+V L NR ++ EL ++ L ++
Sbjct: 1337 VCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYELNALQLEK 1396
Query: 400 AKS 402
S
Sbjct: 1397 TSS 1399
Score = 55.8 bits (133), Expect = 8e-08
Identities = 69/328 (21%), Positives = 143/328 (43%), Gaps = 36/328 (10%)
Query: 134 KKVARYLHQSGALTMEALEDPSP------------ELMEGPEEDIADKVVFLERRVLELE 181
+++ R L+Q+ EA+++ S E + + + +V + R E
Sbjct: 1439 RELGRQLNQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAE 1498
Query: 182 KDTAATGEQ-HSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMER- 239
K+ Q HS ++ L+ + + LKEQ ++ E +L+ + +KE K++R
Sbjct: 1499 KNIQHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRL 1558
Query: 240 ----EKSIEI-ENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRL 294
EKS E E L+ ++++L +N+E + ++A E + EKQ + E+L ++
Sbjct: 1559 NEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQA 1618
Query: 295 SEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQR-------- 346
++ R + L + Q + + L EDL K + K + +Q+
Sbjct: 1619 DGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTK 1678
Query: 347 ---RGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSL 403
R ++ + + R E +++ + ++++ N LK+ +EL+ + I + K +
Sbjct: 1679 KEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMV 1738
Query: 404 F----STAFSESLAAEISSVSRDELMEA 427
S F +S AE ++LME+
Sbjct: 1739 LFQEESGKFKQS--AEEFRKKMEKLMES 1764
Score = 53.5 bits (127), Expect = 4e-07
Identities = 59/249 (23%), Positives = 109/249 (43%), Gaps = 34/249 (13%)
Query: 210 EQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCL 269
++L+E+E++ C+ ET ++R+K+ +EN +L + SEL L
Sbjct: 1100 KRLEEEEIKRCK----ETSEHGAYSDLLQRQKATVLEN-----SKLTGKISELERMVAEL 1150
Query: 270 KANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDL 329
K R+EEE K+ + E+ + E+ R E Q++R+ E E
Sbjct: 1151 KKQKSRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAA 1210
Query: 330 RKQLEHLQLLKLEAEQRRGRSSSMGLQ---------------EYHSRARE---SELEQEV 371
++LE ++ L +EAE +R L E H + ++ ++LEQ+
Sbjct: 1211 ERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQK 1270
Query: 372 RRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQ 431
+L ++ R ++ EEL + L Q K L AF + +A + + +EA +K
Sbjct: 1271 NKLMEELRRKRDNEEEL----LKLIKQMEKDL---AFQKQVAEKQLKEKQKIELEARRKI 1323
Query: 432 EEINFRLQD 440
EI + ++
Sbjct: 1324 TEIQYTCRE 1332
Score = 43.5 bits (101), Expect = 4e-04
Identities = 38/177 (21%), Positives = 81/177 (45%), Gaps = 17/177 (9%)
Query: 178 LELEKDTAATGEQHSRLRQENLQ-LVHRANALEEQLK----EQELRACEMVL-------- 224
L K+ GEQ +L+Q +Q L +R ++++L E+++ +MVL
Sbjct: 1688 LNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKF 1747
Query: 225 ----EETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK 280
EE R++ E L + + +I ++ L +ENS + + NI+ LE +
Sbjct: 1748 KQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQL 1807
Query: 281 QKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQ 337
Q+ ++++ + + +++ D L ++ + + K+ + I++ QL LQ
Sbjct: 1808 QQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQ 1864
Score = 42.0 bits (97), Expect = 0.001
Identities = 59/301 (19%), Positives = 126/301 (41%), Gaps = 34/301 (11%)
Query: 163 EEDIADKVVFLERRV-LELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACE 221
E++ A++ + R++ +E E AA E R + + LE+ LK ++L
Sbjct: 1206 EKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLS--- 1262
Query: 222 MVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQ 281
L + +QK L + R K E L ++Q++++ + + +++E E +
Sbjct: 1263 --LNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEAR 1320
Query: 282 KLLDEIE-----------------SLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQE 324
+ + EI+ S +QE+ ++ + L + + ++
Sbjct: 1321 RKITEIQYTCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQ 1380
Query: 325 LIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQ 384
+ +L +L LQL K +E+ + R L E ++ R +LE E R Q + +Q
Sbjct: 1381 DMRELTYELNALQLEKTSSEE-KARLLKDKLDETNNTLRCLKLELE--RKDQAEKGYSQQ 1437
Query: 385 NEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDR 444
EL Q+ + + +++ A+++ + R+ +E ++ +LQ +DR
Sbjct: 1438 LRELGRQLNQTTGKAEEAM-------QEASDLKKIKRNYQLE-LESLNHEKGKLQREVDR 1489
Query: 445 I 445
I
Sbjct: 1490 I 1490
Score = 38.1 bits (87), Expect = 0.017
Identities = 53/250 (21%), Positives = 105/250 (42%), Gaps = 36/250 (14%)
Query: 163 EEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQL------VHRANALEEQLKEQE 216
E+D K+ LE +L K E + Q+N+ + V NA KE++
Sbjct: 1639 EQDFQRKIKCLEE---DLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEK 1695
Query: 217 LRACEMVLEETRRQKEL---LCKMERE---KSIEIENLQTRLQQLDEENSELRSCTPCLK 270
R + V + + +EL L K++ E K+IE + ++ EE+ + + +
Sbjct: 1696 RRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFR 1755
Query: 271 ANIERLEEEKQKLLDEIESLTLR-LSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDL 329
+E+L E K ++I + L +S +QEN R Q + + + I++L
Sbjct: 1756 KKMEKLMESKVITENDISGIRLDFVSLQQENSRA------------QENAKLCETNIKEL 1803
Query: 330 RKQLEHLQLLKLEAEQRRGRSSSMGLQEYHS-RARESELEQEVRRLKQDNRNLKEQNEEL 388
+QL+ + ++ + M Y + E EL + R ++ + + +Q +E
Sbjct: 1804 ERQLQ-------QYREQMQQGQHMEANHYQKCQKLEDELIAQKREVENLKQKMDQQIKEH 1856
Query: 389 NGQIITLSIQ 398
Q++ L +
Sbjct: 1857 EHQLVLLQCE 1866
Score = 32.3 bits (72), Expect = 0.93
Identities = 43/202 (21%), Positives = 75/202 (37%), Gaps = 40/202 (19%)
Query: 245 IENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRM 304
+ NLQ+R + E++ E + + ++I +LE+E + L E++ +
Sbjct: 683 LSNLQSRFEDFLEDSQESQVFSG---SDITQLEKEVNVCKQYYQELLKSAEREEQEESVY 739
Query: 305 GDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARE 364
+S R+ R + LI +R LE L E R E
Sbjct: 740 NLYISEVRNIRLRLENCEDRLIRQIRTPLERDDL-----------------HESVFRITE 782
Query: 365 SE-LEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDE 423
E L++E+ RLK D + + EE FS++ A+ R E
Sbjct: 783 QEKLKKELERLKDDLGTITNKCEEF-------------------FSQAAASSSVPTLRSE 823
Query: 424 LMEAIQKQEEINFRLQDYIDRI 445
L +Q ++ YID++
Sbjct: 824 LNVVLQNMNQVYSMSSTYIDKL 845
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 64.3 bits (155), Expect = 2e-10
Identities = 79/308 (25%), Positives = 133/308 (43%), Gaps = 51/308 (16%)
Query: 176 RVLELEKDTAATGEQHSRLRQEN---LQLVHRANALEEQLKEQELRACEMVLEETRRQKE 232
+V EL++ A Q RL+ E+ +L+ L QL + A + LEE RRQ E
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQS-LEELRRQLE 1369
Query: 233 LL-----------------CKMEREKSIEIENLQTRLQQ-LDEENSELRSCTPCLKAN-- 272
C + RE+ E Q LQ+ L + N+E+ +A+
Sbjct: 1370 EESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAI 1429
Query: 273 --IERLEEEKQKL-----------------LDEIESLTLRLSEEQENKRRMGDRLSHERH 313
E LEE K+KL +E LRL E E+ +R +
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAA 1489
Query: 314 QFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRR 373
+ + + +E+ R+Q E +Q +LEA QR R +G + + R E + +
Sbjct: 1490 ALDKKQRHLERALEERRRQEEEMQ-RELEAAQRESR--GLGTELFRLRHGHEEALEALET 1546
Query: 374 LKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSV--SRDELMEAIQKQ 431
LK++N+NL+E+ +L Q ++LS + + L T ++L E S + + +E A++ +
Sbjct: 1547 LKRENKNLQEEISDLTDQ-VSLSGKSIQELEKT--KKALEGEKSEIQAALEEAEGALELE 1603
Query: 432 EEINFRLQ 439
E R+Q
Sbjct: 1604 ETKTLRIQ 1611
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/247 (25%), Positives = 104/247 (42%), Gaps = 32/247 (12%)
Query: 169 KVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQL---------------- 212
K+ L+ R ELE++ A +R+ ++ + L E+L
Sbjct: 1156 KIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRK 1215
Query: 213 KEQELRACEMVLEETRRQKELLCKMEREKSIE--------IENLQTRLQQLDEENSELRS 264
+E EL LEE + E R K E +++LQ Q+L++E SELR
Sbjct: 1216 REAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRM 1275
Query: 265 CTPCLKANIERLEEEKQKLLDEIESLTLRLSEE----QENKRRMGDRLSHERHQFQRDKE 320
L AN+E L K + +LSE +E +R++ D S +R + Q +
Sbjct: 1276 EVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLAD-ASTQRGRLQTESG 1334
Query: 321 ATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRN 380
L+E+ K+ QL + +A + E S+A+ S L V+ L+ D
Sbjct: 1335 ELSRLLEE--KECLISQLSRGKALAAQSLEELRRQLEEESKAK-SALAHAVQALRHDCDL 1391
Query: 381 LKEQNEE 387
L+EQ+EE
Sbjct: 1392 LREQHEE 1398
Score = 53.5 bits (127), Expect = 4e-07
Identities = 74/299 (24%), Positives = 124/299 (41%), Gaps = 47/299 (15%)
Query: 178 LELEKDTAATGEQHSRLR-QENLQLVHRANALEEQLKEQE-----LRACEMVLEE--TRR 229
L+ E+D A E+ L + +QL + L E+L+++E L A LE+ T
Sbjct: 940 LQAEQDNLADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTEL 999
Query: 230 QKEL------LCKMEREKSI---EIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEK 280
+K++ L K E+EK +++NL + LDE + L L+ ++ +
Sbjct: 1000 KKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL 1059
Query: 281 QKLLDEIESLT------------LRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIED 328
Q D + +LT L S EQE K RM + + + + D + TQE + D
Sbjct: 1060 QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERA--KRKLEGDLKLTQESVAD 1117
Query: 329 -----------LRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQD 377
L+K+ L L L E + + M + +AR ELE+E+ +
Sbjct: 1118 AAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAA 1177
Query: 378 NRNLKEQNEELNGQIITLSIQ----GAKSLFSTAFSESLAAEISSVSRDELMEAIQKQE 432
+++Q E ++ LS + G S AE+ + R EL EA + E
Sbjct: 1178 RARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRR-ELEEAALRHE 1235
Score = 53.5 bits (127), Expect = 4e-07
Identities = 65/277 (23%), Positives = 116/277 (41%), Gaps = 18/277 (6%)
Query: 164 EDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLK---------E 214
E++ + L R+ E E+ A + S L + L+L + + +L+ +
Sbjct: 1433 EELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALD 1492
Query: 215 QELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIE 274
++ R E LEE RRQ+E + + E L T L +L + E LK +
Sbjct: 1493 KKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENK 1552
Query: 275 RLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQ-ELIEDLRKQL 333
L+EE L D++ + E ++ K+ + S + + + A + E + LR QL
Sbjct: 1553 NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQL 1612
Query: 334 EHLQLLKLEAEQRRGRSSS--MGLQEYHSRARES---ELEQEVRRLKQDNRNLKEQNEEL 388
E L +K E +++ L+ H RA ES L+ E R + R K+ +L
Sbjct: 1613 E-LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDL 1671
Query: 389 NGQIITLSIQGAKSLFSTAFSESLAAEI--SSVSRDE 423
N + L ++ + A + + A++ RDE
Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDE 1708
Score = 39.7 bits (91), Expect = 0.006
Identities = 58/280 (20%), Positives = 110/280 (39%), Gaps = 41/280 (14%)
Query: 157 ELMEGPEEDIADKVVFLERRVLELEKDTA---ATGEQHSRLRQENLQLVHRANALEEQLK 213
+L+ E+ A+ L+R + + + A + E + R E L+ + AL Q
Sbjct: 1390 DLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA 1449
Query: 214 EQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANI 273
E+ + A + K L + ++E+E + LD++ + ++
Sbjct: 1450 EEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK-----------QRHL 1498
Query: 274 ERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQL 333
ER EE+++ +E++ L Q R +G L RH + + L
Sbjct: 1499 ERALEERRRQEEEMQR---ELEAAQRESRGLGTELFRLRHGHE--------------EAL 1541
Query: 334 EHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQII 393
E L+ LK E + + S + Q S ELE+ + L+ + ++ EE G
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEG--- 1598
Query: 394 TLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
L ++ K+L + E+S V + + +K EE
Sbjct: 1599 ALELEETKTL-------RIQLELSQVKAEVDRKLAEKDEE 1631
Score = 35.8 bits (81), Expect = 0.084
Identities = 36/169 (21%), Positives = 70/169 (41%), Gaps = 29/169 (17%)
Query: 249 QTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQEN-------- 300
+ L L E LR +A + LEE + E L L+L EQ+N
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954
Query: 301 -------------KRRMGDRLSHERHQFQRDKEATQELIED----LRKQLEHLQLLKLEA 343
+ + +RL E + D A + +ED L+K ++ L+L +A
Sbjct: 955 HLLIKSKVQLEGKVKELSERLEDE-EEVNADLAARRRKLEDECTELKKDIDDLKLTLAKA 1013
Query: 344 EQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI 392
E+ + + + + + + L++ V RL ++ + L+E +++ G +
Sbjct: 1014 EKEKQATEN---KVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL 1059
Score = 35.4 bits (80), Expect = 0.11
Identities = 57/272 (20%), Positives = 111/272 (40%), Gaps = 42/272 (15%)
Query: 194 LRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQ 253
L LQL H E L ++ E+ R +E ++ E + + L+ R
Sbjct: 1671 LNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQ--RLAAELHEQAQALERRAS 1728
Query: 254 QLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEE----QENKRRMGD--R 307
L E ELR+ L+ +Q+LL+ E L L S+ + K+ D +
Sbjct: 1729 LLAAELEELRA---ALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQ 1785
Query: 308 LSHERHQFQRDKEATQE-----------LIEDLRKQLE---HLQLLKLEAEQRRGRSSSM 353
LS E + +++ +E + E+L+K+ + HL+ +K EQ
Sbjct: 1786 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQT------- 1838
Query: 354 GLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLA 413
++E +R E+E + +R K+ + L+ + EL ++ + A++L E
Sbjct: 1839 -VRELQARLEEAE-QAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRV 1896
Query: 414 AEISSVSRDELMEAIQKQEEINFRLQDYIDRI 445
E++ + ++ R+QD +D++
Sbjct: 1897 KELAYQAEEDRKNLA--------RMQDLVDKL 1920
Score = 31.6 bits (70), Expect = 1.6
Identities = 36/208 (17%), Positives = 86/208 (41%), Gaps = 18/208 (8%)
Query: 159 MEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELR 218
+ G E+ A + E + + D A E+ + + + L LE+ ++E + R
Sbjct: 1786 LSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQAR 1845
Query: 219 ACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEE-NSELRSCTPCLKANIERLE 277
E R K+ +++ L+ ++++L+ E ++E + LK + + E
Sbjct: 1846 LEEAEQAALRGGKK-----------QVQKLEAKVRELEAELDAEQKKHAEALK-GVRKHE 1893
Query: 278 EEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQ 337
++L + E L+ Q+ ++ ++ + QF+ ++ + RK L
Sbjct: 1894 RRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELD 1953
Query: 338 LLKLEAEQRRGRSSSMGLQEYHSRARES 365
+AE+R + + + +R R++
Sbjct: 1954 ----DAEERADMAETQA-NKLRARTRDA 1976
>gi|169208122 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 479
Score = 63.9 bits (154), Expect = 3e-10
Identities = 76/278 (27%), Positives = 119/278 (42%), Gaps = 33/278 (11%)
Query: 134 KKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSR 193
+K+ R L + T E L +PE GP KV L+ L K+ + G Q
Sbjct: 131 QKLGRSLFKLKNQTAEPL---APEPPAGPS-----KVEQLQDETNHLRKELESVGRQLQA 182
Query: 194 LRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQ 253
+ N L EE+L+EQE R E E Q+E LC+ E + E L+ + +
Sbjct: 183 EVENNQMLSLLNRRQEERLREQEERLHEQE-ERLHEQEERLCEQEERLCEQEERLREQEE 241
Query: 254 QLDEENSELRSCTPCLKANIERL--------EEEK----QKLLDEIESLTLRLSEEQENK 301
+L E+ L L ERL E+EK ++LL+E+E L L QE +
Sbjct: 242 RLREQEERLHEQEERLCEQEERLCEQEERLCEQEKLPGQERLLEEVEKL-LEQERRQEEQ 300
Query: 302 RRMGDR----------LSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSS 351
R+ +R L ER + Q ++ QE + +L + E +L +LE + R
Sbjct: 301 ERLLERERLLDEVEELLEQERLRQQDERLWQQETLRELERLRELERLRELERLRELERML 360
Query: 352 SMGLQE-YHSRARESELEQEVRRLKQDNRNLKEQNEEL 388
+G + Y RA +E+ + L++Q +EL
Sbjct: 361 ELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKEL 398
Score = 43.5 bits (101), Expect = 4e-04
Identities = 67/280 (23%), Positives = 115/280 (41%), Gaps = 40/280 (14%)
Query: 174 ERRVLELEKDTAATGEQHSR------LRQENLQLVHRANALEEQLKEQELR---ACEMVL 224
+++V DTA +G HS + E LE Q +E + + ++
Sbjct: 47 KKKVNGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLQDLESQYQELAVALDSSSAIIS 106
Query: 225 EETRRQKELLCKMEREKSIEI---ENLQTRLQQLDEENSE-LRSCTPCLKANIERLEEEK 280
+ T L+ + EK EI + L L +L + +E L P + +E+L++E
Sbjct: 107 QLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAGPSKVEQLQDET 166
Query: 281 QKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLK 340
L E+ES+ +L E EN + + L + R + E LR+Q E L
Sbjct: 167 NHLRKELESVGRQLQAEVENNQMLS--LLNRRQE------------ERLREQEERLH--- 209
Query: 341 LEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGA 400
E E+R + QE +E L ++ RL++ L+EQ E L+ Q L Q
Sbjct: 210 -EQEER------LHEQEERLCEQEERLCEQEERLREQEERLREQEERLHEQEERLCEQEE 262
Query: 401 KSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQD 440
+ E L + ++ L+E ++K E R ++
Sbjct: 263 RLCEQ---EERLCEQEKLPGQERLLEEVEKLLEQERRQEE 299
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 63.9 bits (154), Expect = 3e-10
Identities = 82/336 (24%), Positives = 145/336 (43%), Gaps = 35/336 (10%)
Query: 135 KVARYLHQSGALTMEALEDP--SPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHS 192
KV R L A E E S E + D+++++ L+ + + TAA E +
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 193 RLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRL 252
+ QE +L ALEE+ K E + +M +EL ++E+ K + NL+
Sbjct: 1171 KREQEVAEL---KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA-NLEKNK 1226
Query: 253 QQLDEENSELRSCTPCLKANIERLEEEKQKLLD-EIESLTLRLSEEQENKRRMGDRLSHE 311
Q L+ +N EL +C + ++ E K+K LD +++ L ++SE R+ L+ +
Sbjct: 1227 QGLETDNKEL-ACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD----RLRVELAEK 1281
Query: 312 RHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEV 371
+ Q + + L+E+ K + ++ K A + L + +R ++ L +
Sbjct: 1282 ASKLQNELDNVSTLLEEAEK--KGIKFAKDAASLESQLQDTQELLQEETR-QKLNLSSRI 1338
Query: 372 RRLKQDNRNLKEQNEE-------LNGQIITLSIQGA-------------KSLFSTAFSES 411
R+L+++ +L+EQ EE L Q++ L Q A +SL
Sbjct: 1339 RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLL 1398
Query: 412 LAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIV 447
AE S +E A K E+ RLQ +D + V
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Score = 58.9 bits (141), Expect = 9e-09
Identities = 57/228 (25%), Positives = 109/228 (47%), Gaps = 13/228 (5%)
Query: 181 EKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMERE 240
EK T GE + +++ QL+ N L EQL+ + E+ E + L K +
Sbjct: 866 EKQTKVEGELEE-MERKHQQLLEEKNILAEQLQAET----ELFAEAEEMRARLAAKKQEL 920
Query: 241 KSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQEN 300
+ I + +L++R+++ +E N L++ ++A+I+ LEE+ + + L L +
Sbjct: 921 EEI-LHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAK 979
Query: 301 KRRMGDR---LSHERHQFQRDKEATQELIEDLRKQL-EHLQLLKLEAEQRRGRSSSMGLQ 356
++M + L + +F ++K+ ++ I + QL E + K A+ R + +
Sbjct: 980 IKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDL 1039
Query: 357 EYHSRARE---SELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAK 401
E + E ELE+ R+L + +L++Q EL QI L +Q AK
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087
Score = 57.8 bits (138), Expect = 2e-08
Identities = 66/307 (21%), Positives = 142/307 (46%), Gaps = 29/307 (9%)
Query: 157 ELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQE 216
E M E++ D++ E L LE + A Q R +LQ N +++L ++
Sbjct: 1542 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER----DLQTRDEQNEEKKRLLIKQ 1597
Query: 217 LRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERL 276
+R E LE+ R+Q+ L +++ I++++L+ +++ ++ E+ I++L
Sbjct: 1598 VRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV----------IKQL 1647
Query: 277 EEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL 336
+ + ++ D E E R D + + + ++ ++ + I L+++L
Sbjct: 1648 RKLQAQMKD--------YQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASS 1699
Query: 337 QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLS 396
+ + AEQ R + + +S + +S L E RRL+ L+E+ EE + L+
Sbjct: 1700 ERARRHAEQER---DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 397 IQGAKSLFST-AFSESLAAEISSVSR-DELMEAIQKQ-EEINFRLQDYIDRIIVAIMETN 453
+ K+ + LAAE S+ + D + +++Q +E+ +LQ+ ++ + + +
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQE-LEGAVKSKFKAT 1815
Query: 454 PSILEVK 460
S LE K
Sbjct: 1816 ISALEAK 1822
Score = 53.9 bits (128), Expect = 3e-07
Identities = 44/224 (19%), Positives = 113/224 (50%), Gaps = 20/224 (8%)
Query: 223 VLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQK 282
+L+ TR+++EL K E+ ++++ QT+++ EE ++ ++L EEK
Sbjct: 844 LLQVTRQEEELQAK--DEELLKVKEKQTKVEGELEE----------MERKHQQLLEEKNI 891
Query: 283 LLDEIESLTLRLSEEQENKRRMG------DRLSHERHQFQRDKEATQELIEDLRKQLE-H 335
L +++++ T +E +E + R+ + + H+ ++E +++++ +K+++ H
Sbjct: 892 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAH 951
Query: 336 LQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITL 395
+Q L+ + ++ G + L++ + A+ ++E+E+ L+ N ++ + + +I
Sbjct: 952 IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAEC 1011
Query: 396 SIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQ 439
S Q A+ A + + V +L E ++K+E+ L+
Sbjct: 1012 SSQLAEE-EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE 1054
Score = 53.9 bits (128), Expect = 3e-07
Identities = 67/307 (21%), Positives = 136/307 (44%), Gaps = 51/307 (16%)
Query: 178 LELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKM 237
L+ E D +T + + ++ ++ A +LE QL++ + E++ EETR++ L ++
Sbjct: 1285 LQNELDNVSTLLEEAE--KKGIKFAKDAASLESQLQDTQ----ELLQEETRQKLNLSSRI 1338
Query: 238 EREKSIEIENLQTRLQQLDEENSELRSCTPCLKAN--------------IERLEEEKQKL 283
R+ E +LQ + ++ +E L L++ IE LEE K+KL
Sbjct: 1339 -RQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 284 LDEIESLTLRLSEE---QENKRRMGDRLSHERHQFQRDKEATQELIEDL-RKQLEHLQLL 339
L + E+L+ RL E+ + + +RL E D + +++ +L +KQ + QLL
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 340 ---------------KLEAEQRRGRSSSMGLQEYHSRARES--ELEQEVRRLKQDNRNLK 382
+ EAE R + ++ L A E+ E E++ ++L+ D +L
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 383 EQNEELNGQIITL---------SIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
+++ + L ++ ++ E A E + + + M+A++ Q E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 434 INFRLQD 440
+ + +D
Sbjct: 1578 RDLQTRD 1584
Score = 53.5 bits (127), Expect = 4e-07
Identities = 60/257 (23%), Positives = 118/257 (45%), Gaps = 39/257 (15%)
Query: 175 RRVLELE-KDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
++ +E++ KD A E ++ R E ++ + L+ Q+K+ + LEE R ++
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDE---VIKQLRKLQAQMKDYQRE-----LEEARASRDE 1670
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
+ +E ++++L+ + QL EE + E+E+ +L DEI +
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERAR-------RHAEQERDELADEITNSASG 1723
Query: 294 LSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSM 353
S + KRR+ R++ + + ++++ EL+ D R + LQ+ L AE RS++
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELE-EEQSNMELLND-RFRKTTLQVDTLNAELAAERSAA- 1780
Query: 354 GLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLA 413
+ AR+ +L++ N+ LK + +EL G + KS F S +L
Sbjct: 1781 ---QKSDNARQ--------QLERQNKELKAKLQELEGAV--------KSKFKATIS-ALE 1820
Query: 414 AEISSVSRDELMEAIQK 430
A+I + EA ++
Sbjct: 1821 AKIGQLEEQLEQEAKER 1837
Score = 53.1 bits (126), Expect = 5e-07
Identities = 65/315 (20%), Positives = 148/315 (46%), Gaps = 31/315 (9%)
Query: 166 IADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLE 225
+A K LE + +LE E++ L+ E ++ LEEQL E+E ++ LE
Sbjct: 913 LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE 972
Query: 226 ET------RRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEE 279
+ ++ +E + +E + S I+ + ++ E +S+L K N+ ++ +
Sbjct: 973 KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK-NLAKIRNK 1031
Query: 280 KQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEAT--QELIEDLRKQLEHLQ 337
++ ++ ++E RL +E++ ++ + E+ + + D E T Q+ I +L+ Q++ L+
Sbjct: 1032 QEVMISDLEE---RLKKEEKTRQEL------EKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 338 L-LKLEAEQRRGRSSSMGLQEYHS----------RARESELEQEVRRLKQDNRNLKEQNE 386
L L + E+ +G + + H +A+ +EL+++ K ++Q
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 387 ELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQ-EEINFRLQDYIDRI 445
+L+ ++ L + +L +TA + L + EL +A++++ + ++QD R
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTK-REQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Query: 446 IVAIMETNPSILEVK 460
A+ E + + + K
Sbjct: 1202 ATALEELSEQLEQAK 1216
Score = 50.8 bits (120), Expect = 3e-06
Identities = 49/239 (20%), Positives = 106/239 (44%), Gaps = 30/239 (12%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
E + +LE+ + L + +L L++Q+ E + + E+ L+ ++++EL
Sbjct: 1033 EVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL 1092
Query: 234 LCKMER--EKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESL- 290
+ R ++++ N +++L + +EL+ KA+ + E++K+ L +E+E+L
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK 1152
Query: 291 -----------------TLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQL 333
T R E E K+ + + + Q Q ++ +E+L +QL
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL 1212
Query: 334 EHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI 392
E + K E+ + GL+ EL EV+ L+Q + + ++L+ Q+
Sbjct: 1213 EQAKRFKANLEKNK-----QGLE-----TDNKELACEVKVLQQVKAESEHKRKKLDAQV 1261
Score = 50.8 bits (120), Expect = 3e-06
Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 48/317 (15%)
Query: 147 TMEALEDPSPELMEGPE------EDIA---DKVVFLERRVLELEKDTAATGEQHSRLRQE 197
T+E+LE+ +L++ E E+ A DK+ + R L+ E D H R
Sbjct: 1386 TIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR-LQQELDDLTVDLDHQRQVAS 1444
Query: 198 NL--------QLVHRANALEEQLKEQELRACEMVLEETRRQKE---LLCKMEREKSIEI- 245
NL QL+ ++ + E+ RA E R+KE L E+++E
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRA-----EAEAREKETKALSLARALEEALEAK 1499
Query: 246 ENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQEN----- 300
E + + +QL + +L S + N+ LE+ K+ L ++E + +L E ++
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 301 --KRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAE------QRRGRSSS 352
K R+ + + QF+RD + E E+ +K+L Q+ +LEAE QR +S
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEE-KKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 353 MGLQEYHSRARESELE-------QEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFS 405
E + E+++E + +++L++ +K+ EL + A+S S
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 406 TAFSESLAAEISSVSRD 422
+SL AEI + +
Sbjct: 1679 EKKLKSLEAEILQLQEE 1695
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 63.9 bits (154), Expect = 3e-10
Identities = 73/338 (21%), Positives = 158/338 (46%), Gaps = 45/338 (13%)
Query: 159 MEGPEEDIA---DKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQ 215
+E + DIA KVV LE + ++ + ++++++ L + EE+L EQ
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1561
Query: 216 ELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIER 275
+LE+ + + E+ +MER + + +++R ++++E + ++ +E
Sbjct: 1562 A--GTIQMLEQAKLRLEM--EMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 276 LEEEKQKLLDEIESLTLRLS--EEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQL 333
E+KQK+L E L +L+ +Q N+R D S +R ++D + T+ L+ D + L
Sbjct: 1618 EYEDKQKVLREKRELEGKLATLSDQVNRR---DFESEKR--LRKDLKRTKALLADAQLML 1672
Query: 334 EHLQ----------LLKLEAEQ---------RRGRSSSMGLQEYHSR-----ARESELEQ 369
+HL+ LK + E+ + ++ + +++ H + ++ LE+
Sbjct: 1673 DHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEE 1732
Query: 370 EVRRLKQD----NRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRD--E 423
++ RL+++ L+E E++N + A++ A L A++ +++ E
Sbjct: 1733 QLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQE 1792
Query: 424 LMEAIQK-QEEINFRLQDYIDRIIVAIMETNPSILEVK 460
L E +Q Q ++ F Q +D+ +V+ E LE +
Sbjct: 1793 LQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETR 1830
Score = 55.8 bits (133), Expect = 8e-08
Identities = 64/268 (23%), Positives = 116/268 (43%), Gaps = 41/268 (15%)
Query: 173 LERRVLELEK---DTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRR 229
LE R+ EL D TGE S+L A E E+E++ + + ++
Sbjct: 1287 LESRISELTSELTDERNTGESASQLLD--------AETAERLRAEKEMKELQTQYDALKK 1338
Query: 230 QKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPC------LKANIERLEEEKQKL 283
Q E++ E+E ++ RL + E N E+ + + ++ K++L
Sbjct: 1339 QMEVM---------EMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRL 1389
Query: 284 LDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLE----HLQLL 339
E E +L EQ+NKR++ RL Q D E +Q ++ L+K+ + LQ
Sbjct: 1390 QQEFED---KLEVEQQNKRQLERRLG----DLQADSEESQRALQQLKKKCQRLTAELQDT 1442
Query: 340 KLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQ- 398
KL E ++ R+ + ++ + S+ +E +R K L+ + + L + +L Q
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502
Query: 399 GAKSLFSTAFSE---SLAAEISSVSRDE 423
K + F++ SL AE+ +S E
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQE 1530
Score = 48.9 bits (115), Expect = 1e-05
Identities = 70/287 (24%), Positives = 126/287 (43%), Gaps = 43/287 (14%)
Query: 159 MEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELR 218
+E +ED+ + + + V + +D A + ++L + N + E Q K Q L+
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE------KQELQEKLQALQ 1801
Query: 219 ACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEE 278
+ LE++ K L+ + E + I L+TRL+ + L S LK N+E+L E
Sbjct: 1802 SQVEFLEQSMVDKSLVSRQEAK----IRELETRLEFERTQVKRLESLASRLKENMEKLTE 1857
Query: 279 EKQKLL---DEIESLTLRLSEE-QENKRRMGD------RLSHERHQFQRDKE----ATQE 324
E+ + + + + RL + ++ K MG+ S ++H+ + D E A Q
Sbjct: 1858 ERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQS 1917
Query: 325 LIEDLR---KQLEHLQLL---KLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDN 378
L DL+ K++ LQ ++E+++ +S G + +SELE V
Sbjct: 1918 LQADLKLAFKRIGDLQAAIEDEMESDENEDLINSEGDSDV-----DSELEDRV------- 1965
Query: 379 RNLKEQNEELNGQIITLSIQGA-KSLFSTAFSESLAAEISSVSRDEL 424
+K + G S G+ KS T++ +SLA + S D L
Sbjct: 1966 DGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPL 2012
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/241 (21%), Positives = 106/241 (43%), Gaps = 20/241 (8%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKE 232
LERR+ +L+ D+ + +L+++ +L + L+ Q++R E+ ++ R E
Sbjct: 1407 LERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSE 1466
Query: 233 LLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL 292
L + + + E LQ ++L E L + LK +E + + ++ SL
Sbjct: 1467 L---SQAHEEAQREKLQR--EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEA 1521
Query: 293 RLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLL---KLEAEQRRGR 349
L + + + L+ + Q + + ++ E+L +Q +Q+L KL E R
Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581
Query: 350 SSSMGLQEYHSR------ARES------ELEQEVRRLKQDNRNLKEQNEELNGQIITLSI 397
+E SR AR+S ++E ++ +D + + + EL G++ TLS
Sbjct: 1582 MRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSD 1641
Query: 398 Q 398
Q
Sbjct: 1642 Q 1642
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/153 (23%), Positives = 77/153 (50%), Gaps = 18/153 (11%)
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ 298
R K EI+ L+++L++ ++E +ELR N +RLE I LT L++E+
Sbjct: 1257 RNKDEEIQQLRSKLEKAEKERNELR-------LNSDRLE-------SRISELTSELTDER 1302
Query: 299 ---ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGL 355
E+ ++ D + ER + +++ + Q + L+KQ+E +++ +EA R + +
Sbjct: 1303 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1362
Query: 356 QEYHSRAR-ESELEQEVRRLKQDNRNLKEQNEE 387
+ + + E+ VR + + L+++ E+
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFED 1395
Score = 29.6 bits (65), Expect = 6.0
Identities = 47/220 (21%), Positives = 91/220 (41%), Gaps = 34/220 (15%)
Query: 198 NLQLVHRANALEEQLK--EQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQ- 254
N +V A+EE L+ + E +C M L + L ++E ++ + T Q
Sbjct: 1139 NYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAA 1198
Query: 255 ----LDEENSELRSCTP----CLKANIERLEEEKQ----KLLDEIESLT-LRLSEEQ--- 298
L ++ + R C++ NI++ + K KL + L ++LSEEQ
Sbjct: 1199 CRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRN 1258
Query: 299 -----ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSM 353
+ R ++ ER++ + + + + I +L +L E+ G S+S
Sbjct: 1259 KDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTD--------ERNTGESASQ 1310
Query: 354 GLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQII 393
L A E+E++ L+ LK+Q E + +++
Sbjct: 1311 LLDA--ETAERLRAEKEMKELQTQYDALKKQMEVMEMEVM 1348
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 63.9 bits (154), Expect = 3e-10
Identities = 73/338 (21%), Positives = 158/338 (46%), Gaps = 45/338 (13%)
Query: 159 MEGPEEDIA---DKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQ 215
+E + DIA KVV LE + ++ + ++++++ L + EE+L EQ
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1561
Query: 216 ELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIER 275
+LE+ + + E+ +MER + + +++R ++++E + ++ +E
Sbjct: 1562 A--GTIQMLEQAKLRLEM--EMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 276 LEEEKQKLLDEIESLTLRLS--EEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQL 333
E+KQK+L E L +L+ +Q N+R D S +R ++D + T+ L+ D + L
Sbjct: 1618 EYEDKQKVLREKRELEGKLATLSDQVNRR---DFESEKR--LRKDLKRTKALLADAQLML 1672
Query: 334 EHLQ----------LLKLEAEQ---------RRGRSSSMGLQEYHSR-----ARESELEQ 369
+HL+ LK + E+ + ++ + +++ H + ++ LE+
Sbjct: 1673 DHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEE 1732
Query: 370 EVRRLKQD----NRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRD--E 423
++ RL+++ L+E E++N + A++ A L A++ +++ E
Sbjct: 1733 QLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQE 1792
Query: 424 LMEAIQK-QEEINFRLQDYIDRIIVAIMETNPSILEVK 460
L E +Q Q ++ F Q +D+ +V+ E LE +
Sbjct: 1793 LQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETR 1830
Score = 55.8 bits (133), Expect = 8e-08
Identities = 64/268 (23%), Positives = 116/268 (43%), Gaps = 41/268 (15%)
Query: 173 LERRVLELEK---DTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRR 229
LE R+ EL D TGE S+L A E E+E++ + + ++
Sbjct: 1287 LESRISELTSELTDERNTGESASQLLD--------AETAERLRAEKEMKELQTQYDALKK 1338
Query: 230 QKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPC------LKANIERLEEEKQKL 283
Q E++ E+E ++ RL + E N E+ + + ++ K++L
Sbjct: 1339 QMEVM---------EMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRL 1389
Query: 284 LDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLE----HLQLL 339
E E +L EQ+NKR++ RL Q D E +Q ++ L+K+ + LQ
Sbjct: 1390 QQEFED---KLEVEQQNKRQLERRLG----DLQADSEESQRALQQLKKKCQRLTAELQDT 1442
Query: 340 KLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQ- 398
KL E ++ R+ + ++ + S+ +E +R K L+ + + L + +L Q
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502
Query: 399 GAKSLFSTAFSE---SLAAEISSVSRDE 423
K + F++ SL AE+ +S E
Sbjct: 1503 EEKDMDIAGFTQKVVSLEAELQDISSQE 1530
Score = 50.4 bits (119), Expect = 3e-06
Identities = 69/290 (23%), Positives = 130/290 (44%), Gaps = 34/290 (11%)
Query: 159 MEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELR 218
+E +ED+ + + + V + +D A + ++L + N + E Q K Q L+
Sbjct: 1748 LEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE------KQELQEKLQALQ 1801
Query: 219 ACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEE 278
+ LE++ K L+ + E + I L+TRL+ + L S LK N+E+L E
Sbjct: 1802 SQVEFLEQSMVDKSLVSRQEAK----IRELETRLEFERTQVKRLESLASRLKENMEKLTE 1857
Query: 279 EKQKLL---DEIESLTLRLSEE-QENKRRMGD------RLSHERHQFQRDKE----ATQE 324
E+ + + + + RL + ++ K MG+ S ++H+ + D E A Q
Sbjct: 1858 ERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQS 1917
Query: 325 LIEDLR---KQLEHLQLL---KLEAEQRRGRSSSMG--LQEYHSRARESELEQEVRRLKQ 376
L DL+ K++ LQ ++E+++ +S+ + +Y R + E + +V +
Sbjct: 1918 LQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELE 1977
Query: 377 DN-RNLKEQNEELNGQIITLSIQGA-KSLFSTAFSESLAAEISSVSRDEL 424
D +K + G S G+ KS T++ +SLA + S D L
Sbjct: 1978 DRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPL 2027
Score = 47.8 bits (112), Expect = 2e-05
Identities = 53/241 (21%), Positives = 106/241 (43%), Gaps = 20/241 (8%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKE 232
LERR+ +L+ D+ + +L+++ +L + L+ Q++R E+ ++ R E
Sbjct: 1407 LERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSE 1466
Query: 233 LLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL 292
L + + + E LQ ++L E L + LK +E + + ++ SL
Sbjct: 1467 L---SQAHEEAQREKLQR--EKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEA 1521
Query: 293 RLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLL---KLEAEQRRGR 349
L + + + L+ + Q + + ++ E+L +Q +Q+L KL E R
Sbjct: 1522 ELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMER 1581
Query: 350 SSSMGLQEYHSR------ARES------ELEQEVRRLKQDNRNLKEQNEELNGQIITLSI 397
+E SR AR+S ++E ++ +D + + + EL G++ TLS
Sbjct: 1582 MRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSD 1641
Query: 398 Q 398
Q
Sbjct: 1642 Q 1642
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/153 (23%), Positives = 77/153 (50%), Gaps = 18/153 (11%)
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ 298
R K EI+ L+++L++ ++E +ELR N +RLE I LT L++E+
Sbjct: 1257 RNKDEEIQQLRSKLEKAEKERNELR-------LNSDRLE-------SRISELTSELTDER 1302
Query: 299 ---ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGL 355
E+ ++ D + ER + +++ + Q + L+KQ+E +++ +EA R + +
Sbjct: 1303 NTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEV 1362
Query: 356 QEYHSRAR-ESELEQEVRRLKQDNRNLKEQNEE 387
+ + + E+ VR + + L+++ E+
Sbjct: 1363 DDDDAGGEWRLKYERAVREVDFTKKRLQQEFED 1395
Score = 29.6 bits (65), Expect = 6.0
Identities = 47/220 (21%), Positives = 91/220 (41%), Gaps = 34/220 (15%)
Query: 198 NLQLVHRANALEEQLK--EQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQ- 254
N +V A+EE L+ + E +C M L + L ++E ++ + T Q
Sbjct: 1139 NYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAA 1198
Query: 255 ----LDEENSELRSCTP----CLKANIERLEEEKQ----KLLDEIESLT-LRLSEEQ--- 298
L ++ + R C++ NI++ + K KL + L ++LSEEQ
Sbjct: 1199 CRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRN 1258
Query: 299 -----ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSM 353
+ R ++ ER++ + + + + I +L +L E+ G S+S
Sbjct: 1259 KDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTD--------ERNTGESASQ 1310
Query: 354 GLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQII 393
L A E+E++ L+ LK+Q E + +++
Sbjct: 1311 LLDA--ETAERLRAEKEMKELQTQYDALKKQMEVMEMEVM 1348
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 63.5 bits (153), Expect = 4e-10
Identities = 66/305 (21%), Positives = 138/305 (45%), Gaps = 32/305 (10%)
Query: 130 RLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGE 189
+L+ K++ R L ++ L + + E M EE++ ++ + ++ ++ + E
Sbjct: 245 QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE 304
Query: 190 QHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQ 249
Q ++R++ ++ + L EQ E+ELR E +E R QKEL RE+ E +Q
Sbjct: 305 QEGKMREQEEKMWRQEKRLREQ--EKELREQE---KELREQKEL-----REQE---EQMQ 351
Query: 250 TRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLS 309
+ +++ E+ ++R + ERL E+++++ EQE K R +
Sbjct: 352 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM------------REQEQKMRDQEERM 399
Query: 310 HERHQFQRDKEATQELIEDLRKQLEHL-QLLKLEAEQRRGRSSSMGLQEYHSRARESELE 368
E+ + R+KE E + +Q+E + + K++ ++++ R +QE E +
Sbjct: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQE------EERIR 453
Query: 369 QEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAI 428
+ ++++++ ++EQ E++ Q + Q K E E E I
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 513
Query: 429 QKQEE 433
+QEE
Sbjct: 514 WEQEE 518
Score = 57.4 bits (137), Expect = 3e-08
Identities = 55/265 (20%), Positives = 123/265 (46%), Gaps = 30/265 (11%)
Query: 149 EALEDPSPELMEGPE--EDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRAN 206
E +++ ++ E E ++ +K+ E ++ E E+ EQ Q+ H
Sbjct: 617 EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKM---WEQQRLPEQKEKLWEHEKM 673
Query: 207 ALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCT 266
+E+++EQE + E E + Q++ ++EK E E+++ R +++ EE +R
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 267 PCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHER-----HQFQRDKEA 321
++ E+++E+++++ ++ E + EQE K RL ++ H+ +++E
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMW-----EQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 322 TQELIEDLRKQLEHL----QLLKLEAEQRRGRSSSMGLQEYHSRARESEL---------- 367
E E +R Q E + + ++ + E+ RG+ M QE +E ++
Sbjct: 789 IWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQ 848
Query: 368 -EQEVRRLKQDNRNLKEQNEELNGQ 391
E+ +++ ++EQ E++ GQ
Sbjct: 849 EEKMEEKMQGQEEKMREQEEKMRGQ 873
Score = 45.8 bits (107), Expect = 8e-05
Identities = 42/195 (21%), Positives = 88/195 (45%), Gaps = 23/195 (11%)
Query: 203 HRANALEEQLKEQELR--ACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENS 260
H A L+ L R + +EE ++++ L S+E+ ++L ++N+
Sbjct: 176 HFAGELQRALSAVSTRHKKADRYIEELTKERDAL-------SLELYRNTITNEELKKKNA 228
Query: 261 ELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKE 320
EL+ P ++ ++ ++L ++E L + Q N + + R +E
Sbjct: 229 ELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTL---------QEEMWRQEE 279
Query: 321 ATQELIEDLRKQLEHL----QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQ 376
+E + +RKQ E + + L+ + + R + M QE R +E EL ++ + L+
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR- 338
Query: 377 DNRNLKEQNEELNGQ 391
+ + L+EQ E++ Q
Sbjct: 339 EQKELREQEEQMQEQ 353
Score = 43.1 bits (100), Expect = 5e-04
Identities = 52/250 (20%), Positives = 103/250 (41%), Gaps = 27/250 (10%)
Query: 163 EEDIADKVVFLER-RVLELEKDTAATGEQHSRLRQENL-----------QLVHRANALEE 210
EE + ++ ER + + E++T E+ + ++EN+ +L + L E
Sbjct: 443 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 502
Query: 211 QLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLK 270
Q K QE EE R +E + E+ K E ++ + Q+ E+ ++R +
Sbjct: 503 QEKMQEQEEKIWEQEEKIRDQEEMWGQEK-KMWRQEKMREQEDQMWEQEEKMRDQEQKMW 561
Query: 271 ANIERLE-------------EEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQR 317
ER+E EEK + + + ++ EE+E R +++ + + Q
Sbjct: 562 DQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 318 DKEATQELIEDLRKQLEHL-QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQ 376
+E E E +++Q E + + + EQ L E + E E QE ++++
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 377 DNRNLKEQNE 386
+ EQ +
Sbjct: 682 QEEKIWEQEK 691
Score = 39.7 bits (91), Expect = 0.006
Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 23/204 (11%)
Query: 189 EQHSRLR-QENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKM-EREKSIEIE 246
EQ ++R QE + + +E+++EQE + E EE R +E KM ++E+ +E +
Sbjct: 515 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ--EEKMRDQEQ--KMWDQEERMEKK 570
Query: 247 NLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL---RLSEEQENKRR 303
+ + D+E ER+ E ++K+ +E E + ++ E++E +
Sbjct: 571 TQEQEKKTWDQEEKMREE---------ERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 304 MGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRAR 363
+++ + + Q +E E E + +Q E K+ +QR + + +
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE-----KMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 364 ESELEQEVRRLKQDNRNLKEQNEE 387
E EQE + +Q+ K Q +E
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQE 700
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 63.2 bits (152), Expect = 5e-10
Identities = 69/324 (21%), Positives = 137/324 (42%), Gaps = 43/324 (13%)
Query: 160 EGPEEDIADKVVFLERRVLELEKDTAATGEQHSR----------LRQENLQLVHRANAL- 208
E +D+A ++ + +R+ ELE+ +A Q + Q LQ + AL
Sbjct: 152 EEESKDLAGRLQYSLQRIQELERALSAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALL 211
Query: 209 -------EEQLKEQELRACEM---VLEETRRQKELLCKMERE-KSIEIENLQT--RLQQL 255
E LK+ +L E + E R +E + KM E ++++ E + R+Q+L
Sbjct: 212 NAHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKEEKKRDIHRIQEL 271
Query: 256 DEENSELRS--------CTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDR 307
+ SEL++ P + + +E+L++E + L E+E L +L + EN + +
Sbjct: 272 ERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQALSLL 331
Query: 308 LSHERHQFQRDKEATQE-----------LIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQ 356
++ + Q +E +E L E + E + L+ + E+ R + + Q
Sbjct: 332 SKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQ 391
Query: 357 EYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEI 416
E R E L+++ +RL L ++ E L Q L++ L + E
Sbjct: 392 EERLRKEEERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFED 451
Query: 417 SSVSRDELMEAIQKQEEINFRLQD 440
+ + ++ Q+ +E+ +L +
Sbjct: 452 LNNEKKSALQLEQQVKELQEKLDE 475
Score = 36.2 bits (82), Expect = 0.064
Identities = 27/136 (19%), Positives = 62/136 (45%), Gaps = 7/136 (5%)
Query: 277 EEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHL 336
+ + Q+L +ES ++ +++ EN + + HQ + K+ E+ + +QLE +
Sbjct: 68 DSQYQELAVALESSSVTINQLNENIESLKQQKKQVEHQLEEAKKTNNEIHKAQMEQLETI 127
Query: 337 QLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLS 396
+L LE + + YH++ E+E + L + ++ +EL + +S
Sbjct: 128 NILTLE-------KADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRIQELERALSAVS 180
Query: 397 IQGAKSLFSTAFSESL 412
Q + S++ E++
Sbjct: 181 TQQQEEDRSSSCREAV 196
Score = 32.0 bits (71), Expect = 1.2
Identities = 80/369 (21%), Positives = 133/369 (36%), Gaps = 60/369 (16%)
Query: 56 SECLDAMEEPDHGALLLLPGRPHPHGQSVITVIGGE-EHFEDYGEGSEAELSPETLCNGQ 114
SE + M EP P P SV+ + E +H EG E +L + N
Sbjct: 276 SELKNQMAEP--------PSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENNQA 327
Query: 115 LGCSDPAFLTPSPTKRLSSKKVARYLHQSGALT-MEALEDPSPELMEGPEEDIADKVVFL 173
L LS ++ R Q L EA E + E + ++ L
Sbjct: 328 LSL-------------LSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTL 374
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
+ + L K +Q RLR+E R E++L +QE R + ++++ L
Sbjct: 375 QEQGERLRKQEQRLRKQEERLRKEE----ERLQKQEKRLWDQEERLWKKEERLQKQEERL 430
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEE--------KQKLLD 285
+ ++ Q + L+ E +K E+L+EE Q+L
Sbjct: 431 ALSQNHKLDKQLAEPQCSFEDLNNEKKSALQLEQQVKELQEKLDEEHLEAASQRNQQLET 490
Query: 286 EIESLTL--------RLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQ----L 333
++ + L L E+E R + + +EAT + DL K+
Sbjct: 491 QLSLVALPGEGDGGQHLDSEEEEAPRPTPNIPED----LESREATSSFM-DLPKEKADGT 545
Query: 334 EHLQLLKLEAEQRRGRSSSM--GLQEYHSR-----ARESELEQEVRRLKQDNRNLKEQNE 386
E ++ +L Q G + M Y S+ R E+E +V RL Q +K +
Sbjct: 546 EQVERRELGFVQPSGVTDGMRESFTVYESQGAVPNTRHQEME-DVIRLAQKEEEMKVKLL 604
Query: 387 ELNGQIITL 395
EL ++ L
Sbjct: 605 ELQELVLPL 613
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 63.2 bits (152), Expect = 5e-10
Identities = 73/277 (26%), Positives = 124/277 (44%), Gaps = 24/277 (8%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
E+ L ++ A E+H + ++ L+ ++ EQEL + LEET QK L
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLR--------QKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
L + + E + Q++EE +R L R+E E + L+ + T R
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 294 -LSEEQENKRRMGD---RLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGR 349
L EE E +++ + RLS + R ++ +E + R E + K++A Q R
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 350 SSSMGLQEYHSRARESELEQE-VRRLKQDNRNLKEQ-NEELNGQIITLSIQGAKSLFSTA 407
+ E ++ EL QE RRL++D + +Q EE G TL + + L +A
Sbjct: 2325 LKA----EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 408 FSESLAAEISSVSR-----DELMEAIQKQ-EEINFRL 438
+E L ++ +SR +E + +KQ EEI +L
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Score = 61.2 bits (147), Expect = 2e-09
Identities = 65/306 (21%), Positives = 126/306 (41%), Gaps = 35/306 (11%)
Query: 138 RYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQE 197
R L ++ A E + EL + +E++ + ++ A +Q R QE
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR------------EEAAVDAQQQKRSIQE 1420
Query: 198 NLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDE 257
LQ + +++ E Q K ++ A E ++ E+ I + LQ L+ +
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAER------------SRLRIEEEIRVVRLQ--LEATER 1466
Query: 258 ENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRR----MGDRLSHERH 313
+ L+A E E +K++ +E E L ++ +E + KR+ + R+ E
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA- 1525
Query: 314 QFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRR 373
+ R+K+ + +E+LR Q E + +AE R R + L E R+ E+EL+ +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRAS 1584
Query: 374 LKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
+ L+ +E + + L + + A +E E R+ ++ E
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKANEA 1641
Query: 434 INFRLQ 439
+ RLQ
Sbjct: 1642 LRLRLQ 1647
Score = 54.7 bits (130), Expect = 2e-07
Identities = 58/246 (23%), Positives = 112/246 (45%), Gaps = 17/246 (6%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKE 232
L+ RV E+ + A E R R++ ++ + + E L QE LE R+Q +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSD 2442
Query: 233 LLCKMEREKSIEIENLQTRLQQ----LDEENSELRSCTPCLKANIERLEEEKQKLLDEIE 288
+ RE E+E + +LQQ L ++ E+++ + ++ + +Q L E +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKD 2500
Query: 289 SLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRG 348
SL R ++ K ++ E + Q+ +E Q + + ++ + L + +E +RR
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL-VASMEEARRRQ 2559
Query: 349 RSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAF 408
+ G+ R ++ EL+Q ++ +Q L E+N+ L Q+ L Q +L A
Sbjct: 2560 HEAEEGV-----RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL---AH 2611
Query: 409 SESLAA 414
SE + A
Sbjct: 2612 SEEVTA 2617
Score = 53.9 bits (128), Expect = 3e-07
Identities = 61/266 (22%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 133 SKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHS 192
++K+ + ++ L++ A E + L + EED+A + E+ + K+ ++ +
Sbjct: 2270 AEKMKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAEKML----KEKMQAVQEAT 2323
Query: 193 RLRQENLQLVHRANALEEQ---LKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQ 249
RL+ E L + +EQ L+E + + + + EET+ + L + ER++ +E+
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMSAEA 2382
Query: 250 TRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ---ENKRRMGD 306
RL+ E S ++ R EE+ Q+ + E + +L + + K +
Sbjct: 2383 ERLKLRVAEMSRAQA----------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 307 RLSHERHQFQRDKEATQELIEDLRKQLEHLQ----LLKLEAEQRRGRSSSMGLQEYHSRA 362
L +R Q D E +E I +L ++ E LQ LL+L++E+ + LQE ++A
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQA 2490
Query: 363 RESELEQEVRRLKQDNRNLKEQNEEL 388
+ E L Q R ++++ +L
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKL 2516
Score = 49.3 bits (116), Expect = 7e-06
Identities = 64/287 (22%), Positives = 122/287 (42%), Gaps = 20/287 (6%)
Query: 166 IADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLE 225
+ ++ L ++ E + E+ RL+ E + + + +EE+L ++ E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 226 ETRRQKELLCKMEREKSIEIENLQ---TRLQQLDEENSELRSCTPCLKANIERLEEEKQK 282
+ R + E + R+K LQ +++Q+ EE + L S A + +L EE
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL-SVAAQEAARLRQLAEED-- 2300
Query: 283 LLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELI-------EDLRKQL-E 334
L + +L ++ +E+ + RL E Q+ KE QE E + +QL E
Sbjct: 2301 -LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 335 HLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI-- 392
Q + E R R M + + R +E+ + R ++D + ++Q EE+ ++
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419
Query: 393 ITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQ 439
L+ Q +L T + + S + L EAI + E +LQ
Sbjct: 2420 TELATQEKVTLVQTL---EIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Score = 48.9 bits (115), Expect = 1e-05
Identities = 62/246 (25%), Positives = 108/246 (43%), Gaps = 33/246 (13%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKME 238
EL+ A+ E+ ++L + +LQ H A A QL+E+ R + E R ++E ++E
Sbjct: 1577 ELQSKRASFAEKTAQL-ERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELE 1632
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ 298
R + E L+ RLQ EE ++ +S + + E EKQK EE
Sbjct: 1633 RWQLKANEALRLRLQA--EEVAQQKS--------LAQAEAEKQK-------------EEA 1669
Query: 299 ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY 358
E + R R Q R +E ++ +E R+ E +L AEQ R + +
Sbjct: 1670 EREAR---RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAETE 1723
Query: 359 HSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISS 418
+ LE+E+ RL+++ ++ +EL ++ + + L S A +E + S
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 419 VSRDEL 424
S+ L
Sbjct: 1784 KSKQRL 1789
Score = 47.0 bits (110), Expect = 4e-05
Identities = 57/272 (20%), Positives = 111/272 (40%), Gaps = 37/272 (13%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELL---- 234
E E+ ++ R RQ ++L R A E +E++ RA + LEE R Q E
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQ-ALEELRLQAEEAERRL 1552
Query: 235 --CKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL 292
++ER + +++ L+T + + E R+ A +ER +E+ + ++
Sbjct: 1553 RQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 293 RLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAE-------- 344
R +++Q R + E ++Q L + + L + EAE
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 345 --QRRGRSSSMGLQEYHSRARESE---------------LEQEVRRLKQDNRNLKEQNEE 387
+RRG++ +++ +E E EQE+ RL+ + ++Q +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 388 LNGQIITLSIQGAKSLFSTAFSESLAAEISSV 419
L ++ L + A +T + L AE++ V
Sbjct: 1732 LEEELARLQREAAA---ATQKRQELEAELAKV 1760
Score = 44.7 bits (104), Expect = 2e-04
Identities = 67/300 (22%), Positives = 128/300 (42%), Gaps = 37/300 (12%)
Query: 145 ALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHR 204
A + AL + + + EED A + ER + E AA GE +RL+ E +
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE---KLAAIGEA-TRLKTEAEIALKE 1858
Query: 205 ANALEEQLKE-------QELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDE 257
A E+L+ Q R E + +E L ++ + E+E + ++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 258 ENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQR 317
+ ++ LKA+ E+ K +L E+E +R + E + S E+ + +
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDTLR-------SKEQAELEA 1969
Query: 318 DKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLK-- 375
++ E+ R++ EAE+R S+ +E +R R++ LE EV RLK
Sbjct: 1970 ARQRQLAAEEERRRR---------EAEER--VQKSLAAEEEAARQRKAALE-EVERLKAK 2017
Query: 376 -QDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEI 434
++ R L+E+ E+ + + + L+ + A+ E A EL + +Q+++ +
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKEQELQQTLQQEQSV 2075
Score = 43.1 bits (100), Expect = 5e-04
Identities = 56/259 (21%), Positives = 111/259 (42%), Gaps = 27/259 (10%)
Query: 190 QHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQ 249
Q +R RQE +Q + A++ Q ++LR + +LEE R E + + +R I ++
Sbjct: 1224 QDARRRQEQIQAMPLADS---QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK 1280
Query: 250 TRLQQLDEENSELRSCT-----PCLKANIERLEEEKQKLLDEIESLTLRLSEE----QEN 300
QL ++L P +++ E + +E L LT S+ E
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 301 KRRMGD--RLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY 358
RRM + RL+ ++ +R++ A E + ++QL +R + +QE
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 359 HSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISS 418
R E+ ++ + Q R+++E+ ++L Q +++ ++ AAE S
Sbjct: 1401 VVRREEAAVDAQ-----QQKRSIQEELQQLR--------QSSEAEIQAKARQAEAAERSR 1447
Query: 419 VSRDELMEAIQKQEEINFR 437
+ +E + ++ Q E R
Sbjct: 1448 LRIEEEIRVVRLQLEATER 1466
Score = 42.4 bits (98), Expect = 9e-04
Identities = 75/328 (22%), Positives = 144/328 (43%), Gaps = 50/328 (15%)
Query: 151 LEDPSPELMEGPEEDIADKVVFLE----RRVLELEKDTAATGEQHSRLRQENLQLV---H 203
+ED + + EE +A K F + + LELE + + + +E +L
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 204 RANALEEQLK--EQELRACEMVL---EETRRQKELLCKMEREKS--IEIENLQTRLQQLD 256
R A EE+ + E E R + + E R++K L ++ER K+ E L+ R +Q
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 257 EENSEL--RSCTPCLKAN-------IERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDR 307
+L + L+A +++ E+E Q+ L + +S+ +L E E RR +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 308 LSHERHQFQRDKEATQELIED---LRKQLEH-----------LQLLKLEAEQ---RRGRS 350
R Q +R+ ++ +E+ L++ E + L+ EAEQ RR ++
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152
Query: 351 SSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSE 410
L++ +A ++E+E+ + +Q R Q ++ ++ TL +Q L T +
Sbjct: 2153 EQAALRQ--KQAADAEMEKHKKFAEQTLR----QKAQVEQELTTLRLQ----LEETDHQK 2202
Query: 411 SLAAEISSVSRDELMEAIQKQEEINFRL 438
+L E + E EA +++ ++ L
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEEL 2230
Score = 36.6 bits (83), Expect = 0.049
Identities = 40/165 (24%), Positives = 73/165 (44%), Gaps = 5/165 (3%)
Query: 136 VARYLHQSGALTMEA--LEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSR 193
+A + L EA L+ S E+ +E + + L++ L EKD+ E+
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-EKDSLLQRERFIE 2510
Query: 194 LRQENL-QLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRL 252
+ L QL A +QL+E++ R + + +E +R + + R + E ++ +
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 253 QQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEE 297
++L + + R L +RL E+ Q LL+E L SEE
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHRAALAHSEE 2614
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 63.2 bits (152), Expect = 5e-10
Identities = 73/277 (26%), Positives = 124/277 (44%), Gaps = 24/277 (8%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
E+ L ++ A E+H + ++ L+ ++ EQEL + LEET QK L
Sbjct: 2157 EQAALRQKQAADAEMEKHKKFAEQTLR--------QKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
L + + E + Q++EE +R L R+E E + L+ + T R
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 294 -LSEEQENKRRMGD---RLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGR 349
L EE E +++ + RLS + R ++ +E + R E + K++A Q R
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 350 SSSMGLQEYHSRARESELEQE-VRRLKQDNRNLKEQ-NEELNGQIITLSIQGAKSLFSTA 407
+ E ++ EL QE RRL++D + +Q EE G TL + + L +A
Sbjct: 2329 LKA----EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2384
Query: 408 FSESLAAEISSVSR-----DELMEAIQKQ-EEINFRL 438
+E L ++ +SR +E + +KQ EEI +L
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Score = 61.2 bits (147), Expect = 2e-09
Identities = 65/306 (21%), Positives = 126/306 (41%), Gaps = 35/306 (11%)
Query: 138 RYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQE 197
R L ++ A E + EL + +E++ + ++ A +Q R QE
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR------------EEAAVDAQQQKRSIQE 1424
Query: 198 NLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDE 257
LQ + +++ E Q K ++ A E ++ E+ I + LQ L+ +
Sbjct: 1425 ELQQLRQSSEAEIQAKARQAEAAER------------SRLRIEEEIRVVRLQ--LEATER 1470
Query: 258 ENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRR----MGDRLSHERH 313
+ L+A E E +K++ +E E L ++ +E + KR+ + R+ E
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA- 1529
Query: 314 QFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRR 373
+ R+K+ + +E+LR Q E + +AE R R + L E R+ E+EL+ +
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRAS 1588
Query: 374 LKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
+ L+ +E + + L + + A +E E R+ ++ E
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKANEA 1645
Query: 434 INFRLQ 439
+ RLQ
Sbjct: 1646 LRLRLQ 1651
Score = 54.7 bits (130), Expect = 2e-07
Identities = 58/246 (23%), Positives = 112/246 (45%), Gaps = 17/246 (6%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKE 232
L+ RV E+ + A E R R++ ++ + + E L QE LE R+Q +
Sbjct: 2389 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSD 2446
Query: 233 LLCKMEREKSIEIENLQTRLQQ----LDEENSELRSCTPCLKANIERLEEEKQKLLDEIE 288
+ RE E+E + +LQQ L ++ E+++ + ++ + +Q L E +
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKD 2504
Query: 289 SLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRG 348
SL R ++ K ++ E + Q+ +E Q + + ++ + L + +E +RR
Sbjct: 2505 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL-VASMEEARRRQ 2563
Query: 349 RSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAF 408
+ G+ R ++ EL+Q ++ +Q L E+N+ L Q+ L Q +L A
Sbjct: 2564 HEAEEGV-----RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL---AH 2615
Query: 409 SESLAA 414
SE + A
Sbjct: 2616 SEEVTA 2621
Score = 53.9 bits (128), Expect = 3e-07
Identities = 61/266 (22%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 133 SKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHS 192
++K+ + ++ L++ A E + L + EED+A + E+ + K+ ++ +
Sbjct: 2274 AEKMKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAEKML----KEKMQAVQEAT 2327
Query: 193 RLRQENLQLVHRANALEEQ---LKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQ 249
RL+ E L + +EQ L+E + + + + EET+ + L + ER++ +E+
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMSAEA 2386
Query: 250 TRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ---ENKRRMGD 306
RL+ E S ++ R EE+ Q+ + E + +L + + K +
Sbjct: 2387 ERLKLRVAEMSRAQA----------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2436
Query: 307 RLSHERHQFQRDKEATQELIEDLRKQLEHLQ----LLKLEAEQRRGRSSSMGLQEYHSRA 362
L +R Q D E +E I +L ++ E LQ LL+L++E+ + LQE ++A
Sbjct: 2437 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQA 2494
Query: 363 RESELEQEVRRLKQDNRNLKEQNEEL 388
+ E L Q R ++++ +L
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKL 2520
Score = 49.3 bits (116), Expect = 7e-06
Identities = 64/287 (22%), Positives = 122/287 (42%), Gaps = 20/287 (6%)
Query: 166 IADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLE 225
+ ++ L ++ E + E+ RL+ E + + + +EE+L ++ E+
Sbjct: 2188 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2247
Query: 226 ETRRQKELLCKMEREKSIEIENLQ---TRLQQLDEENSELRSCTPCLKANIERLEEEKQK 282
+ R + E + R+K LQ +++Q+ EE + L S A + +L EE
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL-SVAAQEAARLRQLAEED-- 2304
Query: 283 LLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELI-------EDLRKQL-E 334
L + +L ++ +E+ + RL E Q+ KE QE E + +QL E
Sbjct: 2305 -LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 335 HLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI-- 392
Q + E R R M + + R +E+ + R ++D + ++Q EE+ ++
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2423
Query: 393 ITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQ 439
L+ Q +L T + + S + L EAI + E +LQ
Sbjct: 2424 TELATQEKVTLVQTL---EIQRQQSDHDAERLREAIAELEREKEKLQ 2467
Score = 48.9 bits (115), Expect = 1e-05
Identities = 62/246 (25%), Positives = 108/246 (43%), Gaps = 33/246 (13%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKME 238
EL+ A+ E+ ++L + +LQ H A A QL+E+ R + E R ++E ++E
Sbjct: 1581 ELQSKRASFAEKTAQL-ERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELE 1636
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ 298
R + E L+ RLQ EE ++ +S + + E EKQK EE
Sbjct: 1637 RWQLKANEALRLRLQA--EEVAQQKS--------LAQAEAEKQK-------------EEA 1673
Query: 299 ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY 358
E + R R Q R +E ++ +E R+ E +L AEQ R + +
Sbjct: 1674 EREAR---RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAETE 1727
Query: 359 HSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISS 418
+ LE+E+ RL+++ ++ +EL ++ + + L S A +E + S
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 419 VSRDEL 424
S+ L
Sbjct: 1788 KSKQRL 1793
Score = 47.0 bits (110), Expect = 4e-05
Identities = 57/272 (20%), Positives = 111/272 (40%), Gaps = 37/272 (13%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELL---- 234
E E+ ++ R RQ ++L R A E +E++ RA + LEE R Q E
Sbjct: 1499 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQ-ALEELRLQAEEAERRL 1556
Query: 235 --CKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL 292
++ER + +++ L+T + + E R+ A +ER +E+ + ++
Sbjct: 1557 RQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1615
Query: 293 RLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAE-------- 344
R +++Q R + E ++Q L + + L + EAE
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 345 --QRRGRSSSMGLQEYHSRARESE---------------LEQEVRRLKQDNRNLKEQNEE 387
+RRG++ +++ +E E EQE+ RL+ + ++Q +
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735
Query: 388 LNGQIITLSIQGAKSLFSTAFSESLAAEISSV 419
L ++ L + A +T + L AE++ V
Sbjct: 1736 LEEELARLQREAAA---ATQKRQELEAELAKV 1764
Score = 44.7 bits (104), Expect = 2e-04
Identities = 67/300 (22%), Positives = 128/300 (42%), Gaps = 37/300 (12%)
Query: 145 ALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHR 204
A + AL + + + EED A + ER + E AA GE +RL+ E +
Sbjct: 1807 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE---KLAAIGEA-TRLKTEAEIALKE 1862
Query: 205 ANALEEQLKE-------QELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDE 257
A E+L+ Q R E + +E L ++ + E+E + ++
Sbjct: 1863 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1922
Query: 258 ENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQR 317
+ ++ LKA+ E+ K +L E+E +R + E + S E+ + +
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDTLR-------SKEQAELEA 1973
Query: 318 DKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLK-- 375
++ E+ R++ EAE+R S+ +E +R R++ LE EV RLK
Sbjct: 1974 ARQRQLAAEEERRRR---------EAEER--VQKSLAAEEEAARQRKAALE-EVERLKAK 2021
Query: 376 -QDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEI 434
++ R L+E+ E+ + + + L+ + A+ E A EL + +Q+++ +
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKEQELQQTLQQEQSV 2079
Score = 43.1 bits (100), Expect = 5e-04
Identities = 56/259 (21%), Positives = 111/259 (42%), Gaps = 27/259 (10%)
Query: 190 QHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQ 249
Q +R RQE +Q + A++ Q ++LR + +LEE R E + + +R I ++
Sbjct: 1228 QDARRRQEQIQAMPLADS---QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK 1284
Query: 250 TRLQQLDEENSELRSCT-----PCLKANIERLEEEKQKLLDEIESLTLRLSEE----QEN 300
QL ++L P +++ E + +E L LT S+ E
Sbjct: 1285 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1344
Query: 301 KRRMGD--RLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY 358
RRM + RL+ ++ +R++ A E + ++QL +R + +QE
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404
Query: 359 HSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISS 418
R E+ ++ + Q R+++E+ ++L Q +++ ++ AAE S
Sbjct: 1405 VVRREEAAVDAQ-----QQKRSIQEELQQLR--------QSSEAEIQAKARQAEAAERSR 1451
Query: 419 VSRDELMEAIQKQEEINFR 437
+ +E + ++ Q E R
Sbjct: 1452 LRIEEEIRVVRLQLEATER 1470
Score = 42.4 bits (98), Expect = 9e-04
Identities = 75/328 (22%), Positives = 144/328 (43%), Gaps = 50/328 (15%)
Query: 151 LEDPSPELMEGPEEDIADKVVFLE----RRVLELEKDTAATGEQHSRLRQENLQLV---H 203
+ED + + EE +A K F + + LELE + + + +E +L
Sbjct: 1917 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 204 RANALEEQLK--EQELRACEMVL---EETRRQKELLCKMEREKS--IEIENLQTRLQQLD 256
R A EE+ + E E R + + E R++K L ++ER K+ E L+ R +Q
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036
Query: 257 EENSEL--RSCTPCLKAN-------IERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDR 307
+L + L+A +++ E+E Q+ L + +S+ +L E E RR +
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096
Query: 308 LSHERHQFQRDKEATQELIED---LRKQLEH-----------LQLLKLEAEQ---RRGRS 350
R Q +R+ ++ +E+ L++ E + L+ EAEQ RR ++
Sbjct: 2097 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2156
Query: 351 SSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSE 410
L++ +A ++E+E+ + +Q R Q ++ ++ TL +Q L T +
Sbjct: 2157 EQAALRQ--KQAADAEMEKHKKFAEQTLR----QKAQVEQELTTLRLQ----LEETDHQK 2206
Query: 411 SLAAEISSVSRDELMEAIQKQEEINFRL 438
+L E + E EA +++ ++ L
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEEL 2234
Score = 36.6 bits (83), Expect = 0.049
Identities = 40/165 (24%), Positives = 73/165 (44%), Gaps = 5/165 (3%)
Query: 136 VARYLHQSGALTMEA--LEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSR 193
+A + L EA L+ S E+ +E + + L++ L EKD+ E+
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-EKDSLLQRERFIE 2514
Query: 194 LRQENL-QLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRL 252
+ L QL A +QL+E++ R + + +E +R + + R + E ++ +
Sbjct: 2515 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574
Query: 253 QQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEE 297
++L + + R L +RL E+ Q LL+E L SEE
Sbjct: 2575 EELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHRAALAHSEE 2618
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 63.2 bits (152), Expect = 5e-10
Identities = 73/277 (26%), Positives = 124/277 (44%), Gaps = 24/277 (8%)
Query: 174 ERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKEL 233
E+ L ++ A E+H + ++ L+ ++ EQEL + LEET QK L
Sbjct: 2153 EQAALRQKQAADAEMEKHKKFAEQTLR--------QKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 234 LCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLR 293
L + + E + Q++EE +R L R+E E + L+ + T R
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 294 -LSEEQENKRRMGD---RLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGR 349
L EE E +++ + RLS + R ++ +E + R E + K++A Q R
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 350 SSSMGLQEYHSRARESELEQE-VRRLKQDNRNLKEQ-NEELNGQIITLSIQGAKSLFSTA 407
+ E ++ EL QE RRL++D + +Q EE G TL + + L +A
Sbjct: 2325 LKA----EAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSA 2380
Query: 408 FSESLAAEISSVSR-----DELMEAIQKQ-EEINFRL 438
+E L ++ +SR +E + +KQ EEI +L
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Score = 61.2 bits (147), Expect = 2e-09
Identities = 65/306 (21%), Positives = 126/306 (41%), Gaps = 35/306 (11%)
Query: 138 RYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQE 197
R L ++ A E + EL + +E++ + ++ A +Q R QE
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRR------------EEAAVDAQQQKRSIQE 1420
Query: 198 NLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDE 257
LQ + +++ E Q K ++ A E ++ E+ I + LQ L+ +
Sbjct: 1421 ELQQLRQSSEAEIQAKARQAEAAER------------SRLRIEEEIRVVRLQ--LEATER 1466
Query: 258 ENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRR----MGDRLSHERH 313
+ L+A E E +K++ +E E L ++ +E + KR+ + R+ E
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEA- 1525
Query: 314 QFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRR 373
+ R+K+ + +E+LR Q E + +AE R R + L E R+ E+EL+ +
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL-ETAQRSAEAELQSKRAS 1584
Query: 374 LKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEE 433
+ L+ +E + + L + + A +E E R+ ++ E
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE---AERELERWQLKANEA 1641
Query: 434 INFRLQ 439
+ RLQ
Sbjct: 1642 LRLRLQ 1647
Score = 54.7 bits (130), Expect = 2e-07
Identities = 58/246 (23%), Positives = 112/246 (45%), Gaps = 17/246 (6%)
Query: 173 LERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKE 232
L+ RV E+ + A E R R++ ++ + + E L QE LE R+Q +
Sbjct: 2385 LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSD 2442
Query: 233 LLCKMEREKSIEIENLQTRLQQ----LDEENSELRSCTPCLKANIERLEEEKQKLLDEIE 288
+ RE E+E + +LQQ L ++ E+++ + ++ + +Q L E +
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ--EQLLQETQALQQSFLSEKD 2500
Query: 289 SLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRG 348
SL R ++ K ++ E + Q+ +E Q + + ++ + L + +E +RR
Sbjct: 2501 SLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL-VASMEEARRRQ 2559
Query: 349 RSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAF 408
+ G+ R ++ EL+Q ++ +Q L E+N+ L Q+ L Q +L A
Sbjct: 2560 HEAEEGV-----RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL---AH 2611
Query: 409 SESLAA 414
SE + A
Sbjct: 2612 SEEVTA 2617
Score = 53.9 bits (128), Expect = 3e-07
Identities = 61/266 (22%), Positives = 123/266 (46%), Gaps = 29/266 (10%)
Query: 133 SKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHS 192
++K+ + ++ L++ A E + L + EED+A + E+ + K+ ++ +
Sbjct: 2270 AEKMKQVAEEAARLSVAAQE--AARLRQLAEEDLAQQRALAEKML----KEKMQAVQEAT 2323
Query: 193 RLRQENLQLVHRANALEEQ---LKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQ 249
RL+ E L + +EQ L+E + + + + EET+ + L + ER++ +E+
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQLEMSAEA 2382
Query: 250 TRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ---ENKRRMGD 306
RL+ E S ++ R EE+ Q+ + E + +L + + K +
Sbjct: 2383 ERLKLRVAEMSRAQA----------RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2432
Query: 307 RLSHERHQFQRDKEATQELIEDLRKQLEHLQ----LLKLEAEQRRGRSSSMGLQEYHSRA 362
L +R Q D E +E I +L ++ E LQ LL+L++E+ + LQE ++A
Sbjct: 2433 TLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE--TQA 2490
Query: 363 RESELEQEVRRLKQDNRNLKEQNEEL 388
+ E L Q R ++++ +L
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKL 2516
Score = 49.3 bits (116), Expect = 7e-06
Identities = 64/287 (22%), Positives = 122/287 (42%), Gaps = 20/287 (6%)
Query: 166 IADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLE 225
+ ++ L ++ E + E+ RL+ E + + + +EE+L ++ E+
Sbjct: 2184 VEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 226 ETRRQKELLCKMEREKSIEIENLQ---TRLQQLDEENSELRSCTPCLKANIERLEEEKQK 282
+ R + E + R+K LQ +++Q+ EE + L S A + +L EE
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL-SVAAQEAARLRQLAEED-- 2300
Query: 283 LLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELI-------EDLRKQL-E 334
L + +L ++ +E+ + RL E Q+ KE QE E + +QL E
Sbjct: 2301 -LAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 335 HLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQI-- 392
Q + E R R M + + R +E+ + R ++D + ++Q EE+ ++
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419
Query: 393 ITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQ 439
L+ Q +L T + + S + L EAI + E +LQ
Sbjct: 2420 TELATQEKVTLVQTL---EIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Score = 48.9 bits (115), Expect = 1e-05
Identities = 62/246 (25%), Positives = 108/246 (43%), Gaps = 33/246 (13%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKME 238
EL+ A+ E+ ++L + +LQ H A A QL+E+ R + E R ++E ++E
Sbjct: 1577 ELQSKRASFAEKTAQL-ERSLQEEHVAVA---QLREEAERRAQQQAEAERAREEAERELE 1632
Query: 239 REKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQ 298
R + E L+ RLQ EE ++ +S + + E EKQK EE
Sbjct: 1633 RWQLKANEALRLRLQA--EEVAQQKS--------LAQAEAEKQK-------------EEA 1669
Query: 299 ENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY 358
E + R R Q R +E ++ +E R+ E +L AEQ R + +
Sbjct: 1670 EREAR---RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR---LRAETE 1723
Query: 359 HSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISS 418
+ LE+E+ RL+++ ++ +EL ++ + + L S A +E + S
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 419 VSRDEL 424
S+ L
Sbjct: 1784 KSKQRL 1789
Score = 47.0 bits (110), Expect = 4e-05
Identities = 57/272 (20%), Positives = 111/272 (40%), Gaps = 37/272 (13%)
Query: 179 ELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELL---- 234
E E+ ++ R RQ ++L R A E +E++ RA + LEE R Q E
Sbjct: 1495 EAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQ-ALEELRLQAEEAERRL 1552
Query: 235 --CKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTL 292
++ER + +++ L+T + + E R+ A +ER +E+ + ++
Sbjct: 1553 RQAEVERARQVQVA-LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 293 RLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAE-------- 344
R +++Q R + E ++Q L + + L + EAE
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 345 --QRRGRSSSMGLQEYHSRARESE---------------LEQEVRRLKQDNRNLKEQNEE 387
+RRG++ +++ +E E EQE+ RL+ + ++Q +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 388 LNGQIITLSIQGAKSLFSTAFSESLAAEISSV 419
L ++ L + A +T + L AE++ V
Sbjct: 1732 LEEELARLQREAAA---ATQKRQELEAELAKV 1760
Score = 44.7 bits (104), Expect = 2e-04
Identities = 67/300 (22%), Positives = 128/300 (42%), Gaps = 37/300 (12%)
Query: 145 ALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHR 204
A + AL + + + EED A + ER + E AA GE +RL+ E +
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE---KLAAIGEA-TRLKTEAEIALKE 1858
Query: 205 ANALEEQLKE-------QELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDE 257
A E+L+ Q R E + +E L ++ + E+E + ++
Sbjct: 1859 KEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1918
Query: 258 ENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQR 317
+ ++ LKA+ E+ K +L E+E +R + E + S E+ + +
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAEL--ELELGRIRSNAEDTLR-------SKEQAELEA 1969
Query: 318 DKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLK-- 375
++ E+ R++ EAE+R S+ +E +R R++ LE EV RLK
Sbjct: 1970 ARQRQLAAEEERRRR---------EAEER--VQKSLAAEEEAARQRKAALE-EVERLKAK 2017
Query: 376 -QDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEI 434
++ R L+E+ E+ + + + L+ + A+ E A EL + +Q+++ +
Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKEQELQQTLQQEQSV 2075
Score = 43.1 bits (100), Expect = 5e-04
Identities = 56/259 (21%), Positives = 111/259 (42%), Gaps = 27/259 (10%)
Query: 190 QHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQ 249
Q +R RQE +Q + A++ Q ++LR + +LEE R E + + +R I ++
Sbjct: 1224 QDARRRQEQIQAMPLADS---QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIK 1280
Query: 250 TRLQQLDEENSELRSCT-----PCLKANIERLEEEKQKLLDEIESLTLRLSEE----QEN 300
QL ++L P +++ E + +E L LT S+ E
Sbjct: 1281 DYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISET 1340
Query: 301 KRRMGD--RLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEY 358
RRM + RL+ ++ +R++ A E + ++QL +R + +QE
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 359 HSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISS 418
R E+ ++ + Q R+++E+ ++L Q +++ ++ AAE S
Sbjct: 1401 VVRREEAAVDAQ-----QQKRSIQEELQQLR--------QSSEAEIQAKARQAEAAERSR 1447
Query: 419 VSRDELMEAIQKQEEINFR 437
+ +E + ++ Q E R
Sbjct: 1448 LRIEEEIRVVRLQLEATER 1466
Score = 42.4 bits (98), Expect = 9e-04
Identities = 75/328 (22%), Positives = 144/328 (43%), Gaps = 50/328 (15%)
Query: 151 LEDPSPELMEGPEEDIADKVVFLE----RRVLELEKDTAATGEQHSRLRQENLQLV---H 203
+ED + + EE +A K F + + LELE + + + +E +L
Sbjct: 1913 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 204 RANALEEQLK--EQELRACEMVL---EETRRQKELLCKMEREKS--IEIENLQTRLQQLD 256
R A EE+ + E E R + + E R++K L ++ER K+ E L+ R +Q
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 257 EENSEL--RSCTPCLKAN-------IERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDR 307
+L + L+A +++ E+E Q+ L + +S+ +L E E RR +
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 308 LSHERHQFQRDKEATQELIED---LRKQLEH-----------LQLLKLEAEQ---RRGRS 350
R Q +R+ ++ +E+ L++ E + L+ EAEQ RR ++
Sbjct: 2093 AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2152
Query: 351 SSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSE 410
L++ +A ++E+E+ + +Q R Q ++ ++ TL +Q L T +
Sbjct: 2153 EQAALRQ--KQAADAEMEKHKKFAEQTLR----QKAQVEQELTTLRLQ----LEETDHQK 2202
Query: 411 SLAAEISSVSRDELMEAIQKQEEINFRL 438
+L E + E EA +++ ++ L
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEEL 2230
Score = 36.6 bits (83), Expect = 0.049
Identities = 40/165 (24%), Positives = 73/165 (44%), Gaps = 5/165 (3%)
Query: 136 VARYLHQSGALTMEA--LEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSR 193
+A + L EA L+ S E+ +E + + L++ L EKD+ E+
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS-EKDSLLQRERFIE 2510
Query: 194 LRQENL-QLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRL 252
+ L QL A +QL+E++ R + + +E +R + + R + E ++ +
Sbjct: 2511 QEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 253 QQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEE 297
++L + + R L +RL E+ Q LL+E L SEE
Sbjct: 2571 EELQQLEQQRRQQEELLAEENQRLREQLQ-LLEEQHRAALAHSEE 2614
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,545,317
Number of Sequences: 37866
Number of extensions: 896528
Number of successful extensions: 12258
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 407
Number of HSP's successfully gapped in prelim test: 1048
Number of HSP's that attempted gapping in prelim test: 4813
Number of HSP's gapped (non-prelim): 4471
length of query: 460
length of database: 18,247,518
effective HSP length: 106
effective length of query: 354
effective length of database: 14,233,722
effective search space: 5038737588
effective search space used: 5038737588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.