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Search of human proteins with 21361120
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361120 calponin 1, basic, smooth muscle [Homo sapiens]
(297 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361120 calponin 1, basic, smooth muscle [Homo sapiens] 613 e-176
gi|4502923 calponin 3 [Homo sapiens] 414 e-116
gi|4758018 calponin 2 isoform a [Homo sapiens] 363 e-101
gi|41327730 calponin 2 isoform b [Homo sapiens] 306 1e-83
gi|4507357 transgelin 2 [Homo sapiens] 148 5e-36
gi|56549135 transgelin 3 [Homo sapiens] 142 3e-34
gi|56549139 transgelin 3 [Homo sapiens] 142 3e-34
gi|56549137 transgelin 3 [Homo sapiens] 142 3e-34
gi|48255907 transgelin [Homo sapiens] 139 3e-33
gi|48255905 transgelin [Homo sapiens] 139 3e-33
gi|163310745 LIM and calponin homology domains 1 isoform c [Homo... 73 3e-13
gi|163310743 LIM and calponin homology domains 1 isoform b [Homo... 73 3e-13
gi|163310741 LIM and calponin homology domains 1 isoform a [Homo... 73 3e-13
gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens] 59 7e-09
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 54 1e-07
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ... 49 4e-06
gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [... 49 4e-06
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 47 3e-05
gi|154091020 leucine-rich repeats and calponin homology (CH) dom... 46 5e-05
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 45 6e-05
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 44 1e-04
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ... 44 2e-04
gi|33859670 leucine-rich repeats and calponin homology (CH) doma... 44 2e-04
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 40 0.002
gi|21281675 growth arrest-specific 2 like 2 [Homo sapiens] 38 0.009
gi|28372563 growth arrest-specific 2 like 3 [Homo sapiens] 37 0.021
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 36 0.047
gi|219842340 growth arrest-specific 2 [Homo sapiens] 33 0.39
gi|29540559 growth arrest-specific 2 [Homo sapiens] 33 0.39
gi|4885253 growth arrest-specific 2 [Homo sapiens] 33 0.39
>gi|21361120 calponin 1, basic, smooth muscle [Homo sapiens]
Length = 297
Score = 613 bits (1581), Expect = e-176
Identities = 297/297 (100%), Positives = 297/297 (100%)
Query: 1 MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL 60
MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL
Sbjct: 1 MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL 60
Query: 61 CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV 120
CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV
Sbjct: 61 CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV 120
Query: 121 QSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT 180
QSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT
Sbjct: 121 QSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT 180
Query: 181 AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDT 240
AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDT
Sbjct: 181 AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDT 240
Query: 241 LNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA 297
LNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA
Sbjct: 241 LNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELGEPAHNHHAHNYYNSA 297
>gi|4502923 calponin 3 [Homo sapiens]
Length = 329
Score = 414 bits (1063), Expect = e-116
Identities = 201/277 (72%), Positives = 232/277 (83%), Gaps = 2/277 (0%)
Query: 5 HFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFI 64
HFN+GP+YGLSAEVKNK+A KYDHQ E++LR WIE VTG IG NF GLKDGIILCE I
Sbjct: 3 HFNKGPSYGLSAEVKNKIASKYDHQAEEDLRNWIEEVTGMSIGPNFQLGLKDGIILCELI 62
Query: 65 NKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTL 124
NKLQPGSVKK+NES+ NW QLENIGNFIKAI YG+KPHDIFEANDLFEN N TQVQ+TL
Sbjct: 63 NKLQPGSVKKVNESSLNWPQLENIGNFIKAIQAYGMKPHDIFEANDLFENGNMTQVQTTL 122
Query: 125 LALASMAKTKG--NKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAY 182
+ALA +AKTKG +++GVKYAEKQ R+F+ GKL+ G+++IGLQMGTNK ASQ GMTAY
Sbjct: 123 VALAGLAKTKGFHTTIDIGVKYAEKQTRRFDEGKLKAGQSVIGLQMGTNKCASQAGMTAY 182
Query: 183 GTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLN 242
GTRRHLYDPK+ TD+P DQ TISLQMGTNKGASQAGM APGT+R I++ L ++ D
Sbjct: 183 GTRRHLYDPKMQTDKPFDQTTISLQMGTNKGASQAGMLAPGTRRDIYDQKLTLQPVDNST 242
Query: 243 VSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYP 279
+SLQMG+NK ASQ+GM+VYGL RQVYDPKYC P P
Sbjct: 243 ISLQMGTNKVASQKGMSVYGLGRQVYDPKYCAAPTEP 279
>gi|4758018 calponin 2 isoform a [Homo sapiens]
Length = 309
Score = 363 bits (933), Expect = e-101
Identities = 181/275 (65%), Positives = 215/275 (78%), Gaps = 3/275 (1%)
Query: 1 MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL 60
MSS FN+GP+YGLSAEVKN+L KYD Q+E ELR WIEG+TG IG +F GLKDG IL
Sbjct: 1 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 60
Query: 61 CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV 120
C +NKLQPGSV KIN S QNWHQLEN+ NFIKA+ YG+ P D+FEANDLFE+ N TQV
Sbjct: 61 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 120
Query: 121 QSTLLALASMAKTKG--NKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQG 178
Q +LLALA AKTKG + V++GVKY+EKQER F+ ++ G+ +IGLQMGTNK ASQ G
Sbjct: 121 QVSLLALAGKAKTKGLQSGVDIGVKYSEKQERNFDDATMKAGQCVIGLQMGTNKCASQSG 180
Query: 179 MTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHC 238
MTAYGTRRHLYDPK P+D +TISLQMGTNK ASQ GMTAPGT+R I++ LG + C
Sbjct: 181 MTAYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKC 240
Query: 239 DTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYC 273
D ++SLQMG +GA+Q G V+GL RQ+YDPKYC
Sbjct: 241 DNSSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYC 274
Score = 44.7 bits (104), Expect = 1e-04
Identities = 20/34 (58%), Positives = 24/34 (70%)
Query: 243 VSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTP 276
+ LQMG+NK ASQ GMT YG R +YDPK + P
Sbjct: 166 IGLQMGTNKCASQSGMTAYGTRRHLYDPKNHILP 199
>gi|41327730 calponin 2 isoform b [Homo sapiens]
Length = 270
Score = 306 bits (785), Expect = 1e-83
Identities = 160/273 (58%), Positives = 186/273 (68%), Gaps = 38/273 (13%)
Query: 1 MSSAHFNRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIIL 60
MSS FN+GP+YGLSAEVKN+L KYD Q+E ELR WIEG+TG IG +F GLKDG IL
Sbjct: 1 MSSTQFNKGPSYGLSAEVKNRLLSKYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTIL 60
Query: 61 CEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQV 120
C +NKLQPGSV KIN S QNWHQLEN+ NFIKA+ YG+ P D+FEANDLFE+ N TQV
Sbjct: 61 CTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEANDLFESGNMTQV 120
Query: 121 QSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMT 180
Q +LLALA +MGTNK ASQ GMT
Sbjct: 121 QVSLLALAG-------------------------------------KMGTNKCASQSGMT 143
Query: 181 AYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDT 240
AYGTRRHLYDPK P+D +TISLQMGTNK ASQ GMTAPGT+R I++ LG + CD
Sbjct: 144 AYGTRRHLYDPKNHILPPMDHSTISLQMGTNKCASQVGMTAPGTRRHIYDTKLGTDKCDN 203
Query: 241 LNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYC 273
++SLQMG +GA+Q G V+GL RQ+YDPKYC
Sbjct: 204 SSMSLQMGYTQGANQSGQ-VFGLGRQIYDPKYC 235
Score = 41.2 bits (95), Expect = 0.001
Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 228 IFEPG-LGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTP 276
+FE G + L ++ +MG+NK ASQ GMT YG R +YDPK + P
Sbjct: 111 LFESGNMTQVQVSLLALAGKMGTNKCASQSGMTAYGTRRHLYDPKNHILP 160
>gi|4507357 transgelin 2 [Homo sapiens]
Length = 199
Score = 148 bits (374), Expect = 5e-36
Identities = 84/196 (42%), Positives = 115/196 (58%), Gaps = 14/196 (7%)
Query: 7 NRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGN------NFMDGLKDGIIL 60
NRGPAYGLS EV+ K+ ++YD EQ L +WI + +G NF + LKDG +L
Sbjct: 3 NRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVL 62
Query: 61 CEFINKLQP---GSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNH 117
CE IN L P VKKI ST + Q+E I F++A +YG+ DIF+ DL+E N
Sbjct: 63 CELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNM 122
Query: 118 TQVQSTLLALASMAKTKGNKVNVG-----VKYAEKQERKFEPGKLREGRNIIGLQMGTNK 172
VQ TL+ L +A + + + G K +++ R F +L+EG+N+IGLQMGTN+
Sbjct: 123 ACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNR 182
Query: 173 FASQQGMTAYGTRRHL 188
ASQ GMT YG R +
Sbjct: 183 GASQAGMTGYGMPRQI 198
>gi|56549135 transgelin 3 [Homo sapiens]
Length = 199
Score = 142 bits (359), Expect = 3e-34
Identities = 85/196 (43%), Positives = 115/196 (58%), Gaps = 14/196 (7%)
Query: 7 NRGPAYGLSAEVKNKLAQKYDHQREQELREWI-----EGVTGRRIGN-NFMDGLKDGIIL 60
NRGP+YGLS EV+ K+ QKYD E +L +WI E + G +F L DG +L
Sbjct: 3 NRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVL 62
Query: 61 CEFINKLQPGS---VKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNH 117
C+ IN L P + KI+ES + Q+E I F+KA YGV+ DIF+ DL+E +
Sbjct: 63 CKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDM 122
Query: 118 TQVQSTLLALASMAKTKGNKVNVGV-----KYAEKQERKFEPGKLREGRNIIGLQMGTNK 172
VQ TL+AL S+A TK + G + A++ R F +LR+G+N+IGLQMG+NK
Sbjct: 123 AAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNK 182
Query: 173 FASQQGMTAYGTRRHL 188
ASQ GMT YG R +
Sbjct: 183 GASQAGMTGYGMPRQI 198
Score = 44.7 bits (104), Expect = 1e-04
Identities = 19/25 (76%), Positives = 22/25 (88%)
Query: 243 VSLQMGSNKGASQRGMTVYGLPRQV 267
+ LQMGSNKGASQ GMT YG+PRQ+
Sbjct: 174 IGLQMGSNKGASQAGMTGYGMPRQI 198
>gi|56549139 transgelin 3 [Homo sapiens]
Length = 199
Score = 142 bits (359), Expect = 3e-34
Identities = 85/196 (43%), Positives = 115/196 (58%), Gaps = 14/196 (7%)
Query: 7 NRGPAYGLSAEVKNKLAQKYDHQREQELREWI-----EGVTGRRIGN-NFMDGLKDGIIL 60
NRGP+YGLS EV+ K+ QKYD E +L +WI E + G +F L DG +L
Sbjct: 3 NRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVL 62
Query: 61 CEFINKLQPGS---VKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNH 117
C+ IN L P + KI+ES + Q+E I F+KA YGV+ DIF+ DL+E +
Sbjct: 63 CKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDM 122
Query: 118 TQVQSTLLALASMAKTKGNKVNVGV-----KYAEKQERKFEPGKLREGRNIIGLQMGTNK 172
VQ TL+AL S+A TK + G + A++ R F +LR+G+N+IGLQMG+NK
Sbjct: 123 AAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNK 182
Query: 173 FASQQGMTAYGTRRHL 188
ASQ GMT YG R +
Sbjct: 183 GASQAGMTGYGMPRQI 198
Score = 44.7 bits (104), Expect = 1e-04
Identities = 19/25 (76%), Positives = 22/25 (88%)
Query: 243 VSLQMGSNKGASQRGMTVYGLPRQV 267
+ LQMGSNKGASQ GMT YG+PRQ+
Sbjct: 174 IGLQMGSNKGASQAGMTGYGMPRQI 198
>gi|56549137 transgelin 3 [Homo sapiens]
Length = 199
Score = 142 bits (359), Expect = 3e-34
Identities = 85/196 (43%), Positives = 115/196 (58%), Gaps = 14/196 (7%)
Query: 7 NRGPAYGLSAEVKNKLAQKYDHQREQELREWI-----EGVTGRRIGN-NFMDGLKDGIIL 60
NRGP+YGLS EV+ K+ QKYD E +L +WI E + G +F L DG +L
Sbjct: 3 NRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVL 62
Query: 61 CEFINKLQPGS---VKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNH 117
C+ IN L P + KI+ES + Q+E I F+KA YGV+ DIF+ DL+E +
Sbjct: 63 CKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDM 122
Query: 118 TQVQSTLLALASMAKTKGNKVNVGV-----KYAEKQERKFEPGKLREGRNIIGLQMGTNK 172
VQ TL+AL S+A TK + G + A++ R F +LR+G+N+IGLQMG+NK
Sbjct: 123 AAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNK 182
Query: 173 FASQQGMTAYGTRRHL 188
ASQ GMT YG R +
Sbjct: 183 GASQAGMTGYGMPRQI 198
Score = 44.7 bits (104), Expect = 1e-04
Identities = 19/25 (76%), Positives = 22/25 (88%)
Query: 243 VSLQMGSNKGASQRGMTVYGLPRQV 267
+ LQMGSNKGASQ GMT YG+PRQ+
Sbjct: 174 IGLQMGSNKGASQAGMTGYGMPRQI 198
>gi|48255907 transgelin [Homo sapiens]
Length = 201
Score = 139 bits (350), Expect = 3e-33
Identities = 78/197 (39%), Positives = 117/197 (59%), Gaps = 15/197 (7%)
Query: 7 NRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGN------NFMDGLKDGIIL 60
N+GP+YG+S EV++K+ +KYD + E+ L EWI G +G F LK+G+IL
Sbjct: 3 NKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGVIL 62
Query: 61 CEFINKLQPGSVKKI----NESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTN 116
+ +N L P K + N + + Q+E + F+KA YGV D+F+ DLFE +
Sbjct: 63 SKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEGKD 122
Query: 117 HTQVQSTLLALASMAKTKGN-----KVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTN 171
VQ TL+AL S+A TK + N +K A++ +R+F +L+EG+++IGLQMG+N
Sbjct: 123 MAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKHVIGLQMGSN 182
Query: 172 KFASQQGMTAYGTRRHL 188
+ ASQ GMT YG R +
Sbjct: 183 RGASQAGMTGYGRPRQI 199
Score = 42.0 bits (97), Expect = 7e-04
Identities = 18/25 (72%), Positives = 21/25 (84%)
Query: 243 VSLQMGSNKGASQRGMTVYGLPRQV 267
+ LQMGSN+GASQ GMT YG PRQ+
Sbjct: 175 IGLQMGSNRGASQAGMTGYGRPRQI 199
>gi|48255905 transgelin [Homo sapiens]
Length = 201
Score = 139 bits (350), Expect = 3e-33
Identities = 78/197 (39%), Positives = 117/197 (59%), Gaps = 15/197 (7%)
Query: 7 NRGPAYGLSAEVKNKLAQKYDHQREQELREWIEGVTGRRIGN------NFMDGLKDGIIL 60
N+GP+YG+S EV++K+ +KYD + E+ L EWI G +G F LK+G+IL
Sbjct: 3 NKGPSYGMSREVQSKIEKKYDEELEERLVEWIIVQCGPDVGRPDRGRLGFQVWLKNGVIL 62
Query: 61 CEFINKLQPGSVKKI----NESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTN 116
+ +N L P K + N + + Q+E + F+KA YGV D+F+ DLFE +
Sbjct: 63 SKLVNSLYPDGSKPVKVPENPPSMVFKQMEQVAQFLKAAEDYGVIKTDMFQTVDLFEGKD 122
Query: 117 HTQVQSTLLALASMAKTKGN-----KVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTN 171
VQ TL+AL S+A TK + N +K A++ +R+F +L+EG+++IGLQMG+N
Sbjct: 123 MAAVQRTLMALGSLAVTKNDGHYRGDPNWFMKKAQEHKREFTESQLQEGKHVIGLQMGSN 182
Query: 172 KFASQQGMTAYGTRRHL 188
+ ASQ GMT YG R +
Sbjct: 183 RGASQAGMTGYGRPRQI 199
Score = 42.0 bits (97), Expect = 7e-04
Identities = 18/25 (72%), Positives = 21/25 (84%)
Query: 243 VSLQMGSNKGASQRGMTVYGLPRQV 267
+ LQMGSN+GASQ GMT YG PRQ+
Sbjct: 175 IGLQMGSNRGASQAGMTGYGRPRQI 199
>gi|163310745 LIM and calponin homology domains 1 isoform c [Homo
sapiens]
Length = 1056
Score = 73.2 bits (178), Expect = 3e-13
Identities = 37/91 (40%), Positives = 58/91 (63%), Gaps = 1/91 (1%)
Query: 33 ELREWIEGVTGRRIGN-NFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNF 91
E ++WIE VTGR G+ +F GL++GI+LCE +N ++PG VKKIN L+NI F
Sbjct: 26 EAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIILF 85
Query: 92 IKAITKYGVKPHDIFEANDLFENTNHTQVQS 122
++ + G+K +F+ +DL + +N V+S
Sbjct: 86 LRGCKELGLKESQLFDPSDLQDTSNRVTVKS 116
>gi|163310743 LIM and calponin homology domains 1 isoform b [Homo
sapiens]
Length = 1057
Score = 73.2 bits (178), Expect = 3e-13
Identities = 37/91 (40%), Positives = 58/91 (63%), Gaps = 1/91 (1%)
Query: 33 ELREWIEGVTGRRIGN-NFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNF 91
E ++WIE VTGR G+ +F GL++GI+LCE +N ++PG VKKIN L+NI F
Sbjct: 26 EAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIILF 85
Query: 92 IKAITKYGVKPHDIFEANDLFENTNHTQVQS 122
++ + G+K +F+ +DL + +N V+S
Sbjct: 86 LRGCKELGLKESQLFDPSDLQDTSNRVTVKS 116
>gi|163310741 LIM and calponin homology domains 1 isoform a [Homo
sapiens]
Length = 1083
Score = 73.2 bits (178), Expect = 3e-13
Identities = 37/91 (40%), Positives = 58/91 (63%), Gaps = 1/91 (1%)
Query: 33 ELREWIEGVTGRRIGN-NFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNF 91
E ++WIE VTGR G+ +F GL++GI+LCE +N ++PG VKKIN L+NI F
Sbjct: 26 EAQKWIEQVTGRSFGDKDFRTGLENGILLCELLNAIKPGLVKKINRLPTPIAGLDNIILF 85
Query: 92 IKAITKYGVKPHDIFEANDLFENTNHTQVQS 122
++ + G+K +F+ +DL + +N V+S
Sbjct: 86 LRGCKELGLKESQLFDPSDLQDTSNRVTVKS 116
>gi|33598968 LIM domain only 7 isoform 1 [Homo sapiens]
Length = 1349
Score = 58.5 bits (140), Expect = 7e-09
Identities = 28/73 (38%), Positives = 45/73 (61%)
Query: 49 NFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEA 108
+F L++G++LC+ INKL+PG +KKIN + L+NI F+KA + G+K +F
Sbjct: 86 DFRASLENGVLLCDLINKLKPGVIKKINRLSTPIAGLDNINVFLKACEQIGLKEAQLFHP 145
Query: 109 NDLFENTNHTQVQ 121
DL + +N V+
Sbjct: 146 GDLQDLSNRVTVK 158
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 54.3 bits (129), Expect = 1e-07
Identities = 30/75 (40%), Positives = 46/75 (61%), Gaps = 4/75 (5%)
Query: 54 LKDGIILCEFINKLQPGSVKKINESTQNWHQ-LENIGNFIKAITKYGVKPHDIFEANDLF 112
LK+G++LC+ IN+L PGSV+K Q + NI +F+K V +IF+ +DL+
Sbjct: 35 LKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQV---EIFDPDDLY 91
Query: 113 ENTNHTQVQSTLLAL 127
N ++V STLLA+
Sbjct: 92 SGVNFSKVLSTLLAV 106
>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 878
Score = 49.3 bits (116), Expect = 4e-06
Identities = 32/89 (35%), Positives = 55/89 (61%), Gaps = 7/89 (7%)
Query: 54 LKDGIILCEFINKLQPGSV--KKINESTQ--NWHQLENIGNFIKAI-TKYGVKPHDIFEA 108
L+DG++LC+ ++ L PGS+ K IN Q + L+NI F+K K+G++ ++F+
Sbjct: 37 LRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDP 96
Query: 109 NDLFENTNHTQVQSTL--LALASMAKTKG 135
DLF+ + +V S + L+L S+A+ KG
Sbjct: 97 FDLFDVRDFGKVISAVSRLSLHSIAQNKG 125
>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
Length = 839
Score = 49.3 bits (116), Expect = 4e-06
Identities = 32/89 (35%), Positives = 55/89 (61%), Gaps = 7/89 (7%)
Query: 54 LKDGIILCEFINKLQPGSV--KKINESTQ--NWHQLENIGNFIKAI-TKYGVKPHDIFEA 108
L+DG++LC+ ++ L PGS+ K IN Q + L+NI F+K K+G++ ++F+
Sbjct: 37 LRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDP 96
Query: 109 NDLFENTNHTQVQSTL--LALASMAKTKG 135
DLF+ + +V S + L+L S+A+ KG
Sbjct: 97 FDLFDVRDFGKVISAVSRLSLHSIAQNKG 125
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 46.6 bits (109), Expect = 3e-05
Identities = 25/76 (32%), Positives = 45/76 (59%), Gaps = 5/76 (6%)
Query: 54 LKDGIILCEFINKLQPGSVKKINESTQNWHQ-LENIGNFIKAITKYGVKPH-DIFEANDL 111
LKDG++LC + +L PG+++K+ ++ + L NI F++ G + F+ANDL
Sbjct: 35 LKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGC---GASLRLETFDANDL 91
Query: 112 FENTNHTQVQSTLLAL 127
++ N +V S+L+ L
Sbjct: 92 YQGQNFNKVLSSLVTL 107
>gi|154091020 leucine-rich repeats and calponin homology (CH) domain
containing 2 [Homo sapiens]
Length = 765
Score = 45.8 bits (107), Expect = 5e-05
Identities = 33/130 (25%), Positives = 61/130 (46%), Gaps = 11/130 (8%)
Query: 22 LAQKYDHQREQ-----ELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKIN 76
+ +K +H RE+ +LR +E + ++ L DG++LC N ++P SV I+
Sbjct: 635 MRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIH 694
Query: 77 ESTQNWHQL------ENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASM 130
+ +L N+ NF+ A K GV + + + E +V T+ AL +
Sbjct: 695 VPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLEL 754
Query: 131 AKTKGNKVNV 140
TK ++++V
Sbjct: 755 PTTKASQLSV 764
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 45.4 bits (106), Expect = 6e-05
Identities = 28/80 (35%), Positives = 49/80 (61%), Gaps = 5/80 (6%)
Query: 54 LKDGIILCEFINKLQPGSV--KKINESTQ--NWHQLENIGNFIKAIT-KYGVKPHDIFEA 108
L+DG++LC+ +N L P ++ +++N Q + L+NI F+ K+G+K ++FEA
Sbjct: 37 LRDGVLLCQLLNNLLPHAINLREVNLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEA 96
Query: 109 NDLFENTNHTQVQSTLLALA 128
DLF+ + +V TL AL+
Sbjct: 97 FDLFDVQDFGKVIYTLSALS 116
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 44.3 bits (103), Expect = 1e-04
Identities = 26/89 (29%), Positives = 47/89 (52%), Gaps = 6/89 (6%)
Query: 33 ELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQL------E 86
+LR+ +E R + + + L G+ILC+ N+L+P SV I+ + +L +
Sbjct: 543 QLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARK 602
Query: 87 NIGNFIKAITKYGVKPHDIFEANDLFENT 115
N+ +F++A K GV D+ +DL + T
Sbjct: 603 NVESFLEACRKMGVPEADLCSPSDLLQGT 631
>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
[Homo sapiens]
Length = 847
Score = 43.9 bits (102), Expect = 2e-04
Identities = 28/80 (35%), Positives = 49/80 (61%), Gaps = 5/80 (6%)
Query: 54 LKDGIILCEFINKLQPGSV--KKINESTQ--NWHQLENIGNFIKAITK-YGVKPHDIFEA 108
L+DG++LC+ +N L+ S+ K+IN Q + L+NI F+ A + +G++ ++FEA
Sbjct: 37 LRDGVLLCQLLNNLRAHSINLKEINLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEA 96
Query: 109 NDLFENTNHTQVQSTLLALA 128
DLF+ + +V TL L+
Sbjct: 97 FDLFDVRDFGKVIETLSRLS 116
>gi|33859670 leucine-rich repeats and calponin homology (CH) domain
containing 1 [Homo sapiens]
Length = 728
Score = 43.5 bits (101), Expect = 2e-04
Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 9/123 (7%)
Query: 18 VKNKLAQ-KYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKIN 76
++ K+ Q + + + ++LRE IE + + L DG++LC +N ++P SV I+
Sbjct: 569 IRRKMEQMREEKELVEQLRESIEMRLKVSLHEDLGAALMDGVVLCHLVNHIRPRSVASIH 628
Query: 77 ESTQNWHQL------ENIGNFIKAITKYGVKPHDIFEANDLFE-NTNH-TQVQSTLLALA 128
+ +L N+ NF++A K GV D+ D+ + + H + TLLAL
Sbjct: 629 VPSPAVPKLSMAKCRRNVENFLEACRKLGVPEADLCSPCDILQLDFRHIRKTVDTLLALG 688
Query: 129 SMA 131
A
Sbjct: 689 EKA 691
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 40.0 bits (92), Expect = 0.002
Identities = 24/94 (25%), Positives = 45/94 (47%), Gaps = 20/94 (21%)
Query: 54 LKDGIILCEFINKLQPGSVKKINESTQNWHQ-LENIGNFIKA------------------ 94
LKDG++LC + +L PG+++K+ ++ + L NI F++
Sbjct: 35 LKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLELLFPPSQPPQ 94
Query: 95 -ITKYGVKPHDIFEANDLFENTNHTQVQSTLLAL 127
+ + F+ANDL++ N +V S+L+ L
Sbjct: 95 HLVTTILLSASTFDANDLYQGQNFNKVLSSLVTL 128
>gi|21281675 growth arrest-specific 2 like 2 [Homo sapiens]
Length = 880
Score = 38.1 bits (87), Expect = 0.009
Identities = 39/154 (25%), Positives = 65/154 (42%), Gaps = 23/154 (14%)
Query: 21 KLAQKYDHQREQELREWIEGVTGRRI-GNNFMDGLKDGIILCEFINKL----------QP 69
K +++Y +++L EW+ + G I NF+ L+ G++LC+ N + P
Sbjct: 25 KSSEQYLEAMKEDLAEWLRDLYGLDIDAANFLQVLETGLVLCQHANVVTDAALAFLAEAP 84
Query: 70 GSVKKI---------NESTQ--NWHQLENIGNFIKAITK-YGVKPHDIFEANDLFENTNH 117
+KI N + Q + +N+ NFI+ K G++ +FE DL N
Sbjct: 85 AQAQKIPMPRVGVSCNGAAQPGTFQARDNVSNFIQWCRKEMGIQEVLMFETEDLVLRKNV 144
Query: 118 TQVQSTLLALASMAKTKGNKVNVGVKYAEKQERK 151
V LL L A G V+ E+ E +
Sbjct: 145 KNVVLCLLELGRRAWRFGVAAPTLVQLEEEIEEE 178
>gi|28372563 growth arrest-specific 2 like 3 [Homo sapiens]
Length = 694
Score = 37.0 bits (84), Expect = 0.021
Identities = 31/137 (22%), Positives = 60/137 (43%), Gaps = 19/137 (13%)
Query: 31 EQELREWIEGVTGRRI-GNNFMDGLKDGIILCEFINKLQPGSVKKINE------------ 77
+++L W+ G+ G ++ ++ L +G++LC+ I+ LQ VK N
Sbjct: 51 QEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQ-NMVKTCNSEESGNFPMRKVP 109
Query: 78 -----STQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAK 132
++ ++ +N NF+ GV +FE+ L + + QV LL + +
Sbjct: 110 CKKDAASGSFFARDNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVS 169
Query: 133 TKGNKVNVGVKYAEKQE 149
G + V VK ++ E
Sbjct: 170 RYGVEPPVLVKLEKEIE 186
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 35.8 bits (81), Expect = 0.047
Identities = 20/74 (27%), Positives = 33/74 (44%), Gaps = 30/74 (40%)
Query: 54 LKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFE 113
LKDG++LC + +L PG+++K F+ANDL++
Sbjct: 35 LKDGVVLCRLLERLLPGTIEK------------------------------TFDANDLYQ 64
Query: 114 NTNHTQVQSTLLAL 127
N +V S+L+ L
Sbjct: 65 GQNFNKVLSSLVTL 78
>gi|219842340 growth arrest-specific 2 [Homo sapiens]
Length = 313
Score = 32.7 bits (73), Expect = 0.39
Identities = 28/124 (22%), Positives = 51/124 (41%), Gaps = 19/124 (15%)
Query: 31 EQELREWIEGVTGRRI-GNNFMDGLKDGIILCEFINKLQPGSVKKI--NESTQN------ 81
+++L W+ + G+ I FM+ L +G +LC+ +Q + + N+ T+N
Sbjct: 37 KEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKI 96
Query: 82 ----------WHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMA 131
+ +N NF+ GV +FE+ L + +V LL L +A
Sbjct: 97 PCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIA 156
Query: 132 KTKG 135
G
Sbjct: 157 ARYG 160
>gi|29540559 growth arrest-specific 2 [Homo sapiens]
Length = 313
Score = 32.7 bits (73), Expect = 0.39
Identities = 28/124 (22%), Positives = 51/124 (41%), Gaps = 19/124 (15%)
Query: 31 EQELREWIEGVTGRRI-GNNFMDGLKDGIILCEFINKLQPGSVKKI--NESTQN------ 81
+++L W+ + G+ I FM+ L +G +LC+ +Q + + N+ T+N
Sbjct: 37 KEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKI 96
Query: 82 ----------WHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMA 131
+ +N NF+ GV +FE+ L + +V LL L +A
Sbjct: 97 PCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIA 156
Query: 132 KTKG 135
G
Sbjct: 157 ARYG 160
>gi|4885253 growth arrest-specific 2 [Homo sapiens]
Length = 313
Score = 32.7 bits (73), Expect = 0.39
Identities = 28/124 (22%), Positives = 51/124 (41%), Gaps = 19/124 (15%)
Query: 31 EQELREWIEGVTGRRI-GNNFMDGLKDGIILCEFINKLQPGSVKKI--NESTQN------ 81
+++L W+ + G+ I FM+ L +G +LC+ +Q + + N+ T+N
Sbjct: 37 KEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAETMQEKFKESMDANKPTKNLPLKKI 96
Query: 82 ----------WHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMA 131
+ +N NF+ GV +FE+ L + +V LL L +A
Sbjct: 97 PCKTSAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIA 156
Query: 132 KTKG 135
G
Sbjct: 157 ARYG 160
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,263,992
Number of Sequences: 37866
Number of extensions: 472741
Number of successful extensions: 1007
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 906
Number of HSP's gapped (non-prelim): 65
length of query: 297
length of database: 18,247,518
effective HSP length: 102
effective length of query: 195
effective length of database: 14,385,186
effective search space: 2805111270
effective search space used: 2805111270
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.