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Search of human proteins with 21265058
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein [Homo
sapiens]
(950 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 1993 0.0
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 935 0.0
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 800 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 733 0.0
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 726 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 694 0.0
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 691 0.0
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 488 e-137
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 481 e-135
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 468 e-132
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 460 e-129
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 456 e-128
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 444 e-124
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 439 e-123
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 424 e-118
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 413 e-115
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 403 e-112
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 398 e-110
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 397 e-110
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 313 6e-85
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 313 6e-85
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 287 3e-77
gi|145309328 papilin [Homo sapiens] 230 4e-60
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 206 1e-52
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 200 6e-51
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 193 6e-49
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 193 6e-49
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 190 5e-48
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 190 5e-48
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 179 1e-44
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 1993 bits (5162), Expect = 0.0
Identities = 950/950 (100%), Positives = 950/950 (100%)
Query: 1 MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF 60
MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF
Sbjct: 1 MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF 60
Query: 61 QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC 120
QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC
Sbjct: 61 QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC 120
Query: 121 GGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGW 180
GGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGW
Sbjct: 121 GGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGW 180
Query: 181 NPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH 240
NPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH
Sbjct: 181 NPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEH 240
Query: 241 YLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLN 300
YLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLN
Sbjct: 241 YLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLN 300
Query: 301 KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA 360
KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA
Sbjct: 301 KVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTA 360
Query: 361 HELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG 420
HELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG
Sbjct: 361 HELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHG 420
Query: 421 DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVC 480
DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVC
Sbjct: 421 DCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVC 480
Query: 481 QTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLAR 540
QTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLAR
Sbjct: 481 QTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLAR 540
Query: 541 RQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLA 600
RQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLA
Sbjct: 541 RQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLA 600
Query: 601 VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCD 660
VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCD
Sbjct: 601 VAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCD 660
Query: 661 GNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI 720
GNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI
Sbjct: 661 GNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLI 720
Query: 721 GDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT 780
GDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT
Sbjct: 721 GDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT 780
Query: 781 VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP 840
VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP
Sbjct: 781 VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPP 840
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELS 900
ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELS
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWELS 900
Query: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC
Sbjct: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 935 bits (2417), Expect = 0.0
Identities = 480/983 (48%), Positives = 631/983 (64%), Gaps = 85/983 (8%)
Query: 1 MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF 60
+LLL LA + SE + E+VVP L+ R P G ++ AF
Sbjct: 36 LLLLAAALLAVSDALGRPSEEDEELVVP-ELE----------RAP---GHGTTRLRLHAF 81
Query: 61 QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTG-GSSDLRRCFYSGDVNAEPDSFAAVSL 119
+ L L PD+ FLAP F+ +++G T +DL CFYSG VN +P S AA+SL
Sbjct: 82 DQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSAAALSL 141
Query: 120 CGGLRGAFGYRGAEYVISPLPNAS---APAAQRNSQGA----HLLQRRGVPGGPSGDPTS 172
C G+RGAF G Y I PLP AS A AA A HLL+R GD
Sbjct: 142 CEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNR-----QGDVGG 196
Query: 173 RCGVASGWNPAILRA-----------------LDPYKPRRAGFGESRSRRRSGRAKRFVS 215
CGV +A P P G G+ S R KRFVS
Sbjct: 197 TCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTG-SIRKKRFVS 255
Query: 216 IPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDR 275
RYVET++VAD+SM +FHG+ L+HYLLTL + AARLY+HPSI N +++VVVK+L++ D
Sbjct: 256 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDE 315
Query: 276 DSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADV 335
GP+VT NAALTLRNFC WQK+ N SD+ E++DTAILFTRQDLCG+ TCDTLGMADV
Sbjct: 316 QKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMADV 375
Query: 336 GTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLI 395
GT+CDP RSCSVIEDDGL +AFTTAHELGHVFNMPHD+ K C + G + +HMM+ L
Sbjct: 376 GTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASMLS 435
Query: 396 QIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVG 455
+D + PWS CSA +IT FLD+GHG+CL+D+P PI LP DLPG SY ++QC+ FG
Sbjct: 436 NLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGED 495
Query: 456 SKPCP-YMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKH- 513
SK CP C+ LWCTG + G +VCQT+HFPWADGTSCGEGK C+ G CV + + KH
Sbjct: 496 SKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNKTD-RKHF 554
Query: 514 --RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCP 571
GSW W P+G CSRTCGGGVQ R+C NP P NGGKYCEG RV+YRSCNLE CP
Sbjct: 555 DTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
Query: 572 SSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVL 631
+ +GK+FREEQCEA N ++ ++ AV W+PKY+GVSP+D+CKLIC+A G GYF+VL
Sbjct: 615 DN-NGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVL 673
Query: 632 APKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK 691
PKVVDGT CSPDSTSVCVQG+C+KAGCD + SKK+FDKCGVCGG+ +CKK++G T
Sbjct: 674 QPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTS 733
Query: 692 PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLV 751
GY+ ++ IP GA++I+++QR +G + ++LA+K + G Y+LNG + +S +E+D++
Sbjct: 734 AKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIM 793
Query: 752 VKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSH 811
KG +LRYSG+ A+E +++ P+ EPLT++VL+VG P+++Y++++ K+
Sbjct: 794 YKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFVKKKKES----- 848
Query: 812 PKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAG 871
N++ + S WV WG CS SC G Q+R V+CR G
Sbjct: 849 ----------FNAIPTFS------------AWVIEEWGECSKSCELGWQRRLVECRDING 886
Query: 872 QRTVPACDAAH--RPVETQACGE-PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLL 928
Q PA + A +P T+ C + PCP W+L WS CSK+CG+G+++RSLKC+ H G +L
Sbjct: 887 Q---PASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVL 943
Query: 929 ARDQCNLHRKPQE-LDFCVLRPC 950
+ + C+ +KP+ +DFC + C
Sbjct: 944 SHESCDPLKKPKHFIDFCTMAEC 966
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 800 bits (2065), Expect = 0.0
Identities = 423/918 (46%), Positives = 574/918 (62%), Gaps = 67/918 (7%)
Query: 1 MLLLGILTLAFAG--RTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQIT 58
+LLL +L LA R A G + E+VVP RL P +G+ L ++
Sbjct: 15 LLLLLLLPLARGAPARPAAGGQAS-ELVVPTRL-------------PGSAGE--LALHLS 58
Query: 59 AFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVS 118
AF + F L L PD FLAP F E LG + TGG LR CF+SG VN EP+S AAVS
Sbjct: 59 AFGKGFVLRLAPDDSFLAPEFKIERLGGSGRA-TGGERGLRGCFFSGTVNGEPESLAAVS 117
Query: 119 LCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVAS 178
LC GL G+F G E+ I P A AQ H LQR G G V +
Sbjct: 118 LCRGLSGSFLLDGEEFTIQP-QGAGGSLAQ-----PHRLQRWGPAGARPLPRGPEWEVET 171
Query: 179 GWNPAILRALDPYKPRRAGFGESRSRRRS---------GRAKRFVSIPRYVETLVVADES 229
G R D + E + S R KRFVS R+VETL+VAD S
Sbjct: 172 GEGQRQERG-DHQEDSEEESQEEEAEGASEPPPPLGATSRTKRFVSEARFVETLLVADAS 230
Query: 230 MVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTL 289
M F+GADL++++LTL++ AAR+Y+HPSI N IN++VVKVL++ D GP+V+ N LTL
Sbjct: 231 MAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTL 290
Query: 290 RNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGAT-TCDTLGMADVGTMCDPKRSCSVI 348
RNFC WQ++ N+ SD+HPE++DTAIL TRQ+ CG CDTLG+AD+GT+CDP +SCSVI
Sbjct: 291 RNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVI 350
Query: 349 EDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSA 408
ED+GL +A T AHELGHV +MPHD+ K C +FG + +H+M+P + +++ PWS CSA
Sbjct: 351 EDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSA 410
Query: 409 AIITDFLDSGHGDCLLDQPSKPISLPEDLPG--ASYTLSQQCELAFGVGSKPCPY---MQ 463
+T+ LD GHGDCLLD P+ + LP LPG A Y L QQC FG + CP
Sbjct: 411 MYLTELLDGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQD 470
Query: 464 YCTKLWCTGKAKGQMVCQTRH--FPWADGTSCGEGKLCLKGACVERHNLNKHR--VDGSW 519
C +LWC + +C T++ PWADGT CG G LC +G+C+ + + + DG W
Sbjct: 471 VCAQLWCHTDG-AEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGW 529
Query: 520 AKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSF 579
A W P+G CSRTCGGGVQ + R+C +P P NGG+YC G R KY+SC+ E CP GKSF
Sbjct: 530 APWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPD--GKSF 587
Query: 580 REEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGT 639
RE+QCE +N YN++ L + WVPKY+GVSPRD+CKL CRA G F V KV+DGT
Sbjct: 588 REQQCEKYNAYNYTDMDGNL-LQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGT 646
Query: 640 LCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFV 699
LC P++ ++CV+G+C+KAGCD + S ++ DKCGVCGG SC+KV+G T +GYN +
Sbjct: 647 LCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDI 706
Query: 700 VAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRY 759
V IPAGA++ID++QR + G+ D NYLALK + G+YLLNG+ +SA+E+D++VKG++L+Y
Sbjct: 707 VTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKY 766
Query: 760 SGTGTAVESLQASRPILEPLTVEVLSV-GKMTPPRVRYSFYLPKEPREDKSSHPKDPRGP 818
SG+ +E LQ+ RP+ EPLTV++L+V G++ PP+V+Y+F++P + D S R
Sbjct: 767 SGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPND--VDFSMQSSKERAT 824
Query: 819 SVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPAC 878
+ + +L A+WV G W CS++CG+G Q+R V+CR +GQ + C
Sbjct: 825 TNIIQPLLH-------------AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASA-TC 870
Query: 879 DAAHRPVETQAC-GEPCP 895
+ A +P + + C + CP
Sbjct: 871 NKALKPEDAKPCESQLCP 888
Score = 45.4 bits (106), Expect = 2e-04
Identities = 21/54 (38%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W L WS CS +CG G+QRR+++C G+ A CN KP++ C + C
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLC 887
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 733 bits (1893), Expect = 0.0
Identities = 400/965 (41%), Positives = 539/965 (55%), Gaps = 80/965 (8%)
Query: 55 FQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSD----LRRCFYSGDVNAE 110
++++AF + F +LT +A F+AP F+ LG P T S+ L+ CFY G VN
Sbjct: 100 YRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTN 159
Query: 111 PDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDP 170
+ A +SLC G+ G F +Y I PL + + H++ RR P
Sbjct: 160 SEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTG 219
Query: 171 TSRCGVASGWNPAILRALDPYKPRRAGFGE-----------------------------S 201
C + N + D K R +GE +
Sbjct: 220 RHACDTSEHKNR---HSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNT 276
Query: 202 RSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNP 261
R +R R KRF+S PR+VE LVVAD MV +HG +L+HY+LTL++ A +Y+ PSI N
Sbjct: 277 REKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNL 336
Query: 262 INIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDL 321
INIV+V ++++ + GP ++ NA TL+NFC WQ N H DTA+L TRQD+
Sbjct: 337 INIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHH---DTAVLLTRQDI 393
Query: 322 CGA-TTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEV 380
C A CDTLG+A++GT+CDP RSCS+ ED GL +AFT AHELGHVFNMPHD+ C+E
Sbjct: 394 CRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEE 453
Query: 381 FGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQP-SKPISLPEDLPG 439
G H+M+PTL WS CS IT+FLD+G+G+CLL++P S+P LP LPG
Sbjct: 454 -GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPG 512
Query: 440 ASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLC 499
Y +++QCEL FG GS+ CPYM C +LWC C+T+H PWADGT C GK C
Sbjct: 513 ILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHC 572
Query: 500 LKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR 559
G CV + ++ DGSW W P+G CSRTCGGG++ A R+C P P NGGKYC G R
Sbjct: 573 KYGFCVPKE-MDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRR 631
Query: 560 VKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLI 619
+K++SCN EPC + FR+EQC F+G + + N L V WVPKYSG+ +D+CKL
Sbjct: 632 MKFKSCNTEPCLKQK--RDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLF 689
Query: 620 CRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDN 679
CR G +Y L +V+DGT C D+ +CVQG C +AGCD L SK R DKCGVCGGDN
Sbjct: 690 CRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDN 749
Query: 680 KSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNG 739
SCK V G F +GYN VV IPAGA++ID+RQ + G DDNYLAL +S+G++LLNG
Sbjct: 750 SSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNG 809
Query: 740 HFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFY 799
+FVV+ +R++ + +++ YSG+ TAVE + ++ I + L ++VLSVGK+ P VRYSF
Sbjct: 810 NFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFN 869
Query: 800 LPKEPREDK---SSH------PKDPRGPSVLHNSVLSLSNQV---EQPDDRPP------- 840
+P E + + +SH K +G S+Q+ +Q DR P
Sbjct: 870 IPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITE 929
Query: 841 -------ARWVAGSWGPCSASCGSGLQKRAVDCR------GSAGQRTVPACDAAHRPVET 887
RW S CSA CG G + + C G + C + +P
Sbjct: 930 PCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNR 989
Query: 888 QACGEPCPT--WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
+ C C T W SAW+ CSKSC G QRR CV +L +C H++ + C
Sbjct: 990 EKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCT-HQEKVTIQRC 1048
Query: 946 VLRPC 950
PC
Sbjct: 1049 SEFPC 1053
Score = 89.0 bits (219), Expect = 2e-17
Identities = 42/114 (36%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQ-RTVPACDAAHRPVETQACG-EPCPT 896
P +W GSW PCSA+CG G + R V CR G AC RPV + C PC
Sbjct: 1182 PRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQ 1241
Query: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W+ WS CS +CG+G R + CV + ++ R +C+ P+ C + PC
Sbjct: 1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPC 1295
Score = 82.0 bits (201), Expect = 2e-15
Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 4/113 (3%)
Query: 842 RWVAGSWGPCSASCGSGLQKRAVDCR-GSAGQRTVPACDAAHRPVETQACGEP-CP--TW 897
+W AG+W CS SCG G+Q+R V C+ G+ C+ RP + C P CP TW
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTW 1559
Query: 898 ELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W C+K+CG G + R + CV + +C++ ++P + + C L+PC
Sbjct: 1560 RAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 81.6 bits (200), Expect = 3e-15
Identities = 36/121 (29%), Positives = 61/121 (50%), Gaps = 2/121 (1%)
Query: 832 VEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG 891
+++ + P +W +G W C +CG G + R V C+ + CD +P Q C
Sbjct: 1045 IQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQ 1104
Query: 892 EP-CPTWELSAWSPCSKSCGRGFQRRSLKC-VGHGGRLLARDQCNLHRKPQELDFCVLRP 949
+P C +W+ W CS +CG+G+Q R++KC +G ++ + CN +P + C L
Sbjct: 1105 QPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPS 1164
Query: 950 C 950
C
Sbjct: 1165 C 1165
Score = 77.4 bits (189), Expect = 6e-14
Identities = 51/164 (31%), Positives = 70/164 (42%), Gaps = 18/164 (10%)
Query: 799 YLPKEPREDKSSHPKDPRGPSVLHNSVLS---LSNQVEQPDDRPPAR--------WVAGS 847
Y+P E +D S P R P +S L+ N+ +P P+R W G
Sbjct: 1282 YIP-ETDQDCSMSPCPQRTP----DSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGP 1336
Query: 848 WGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE-PCPTWELSAWSPCS 906
WG CS++C G Q+R V C+ G T C +P E +AC PCP W W C+
Sbjct: 1337 WGACSSTCAGGSQRRVVVCQDENGY-TANDCVERIKPDEQRACESGPCPQWAYGNWGECT 1395
Query: 907 KSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
K CG G + R + C G C + KP + + C C
Sbjct: 1396 KLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
Score = 75.1 bits (183), Expect = 3e-13
Identities = 38/107 (35%), Positives = 51/107 (47%), Gaps = 2/107 (1%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQAC-GEPCPTWE 898
A W G W CS SCG G ++R V C G C +P + C G CP W+
Sbjct: 1443 AAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWK 1502
Query: 899 LSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
AWS CS SCGRG Q+R + C ++ +CN + +P+ C
Sbjct: 1503 AGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDC 1549
Score = 62.4 bits (150), Expect = 2e-09
Identities = 30/85 (35%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQACG-EPCP- 895
P W A W C+ +CG G + R V C A CD + RPV+ ++C +PC
Sbjct: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEY 1614
Query: 896 TWELSAWSPCSKSCGRGFQRRSLKC 920
W WS CS +CG+G+++R + C
Sbjct: 1615 VWITGEWSECSVTCGKGYKQRLVSC 1639
Score = 61.2 bits (147), Expect = 4e-09
Identities = 33/114 (28%), Positives = 47/114 (41%), Gaps = 13/114 (11%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDC--------RGSAGQRTVPACDAAHRPVETQACGEPC 894
W+ G W CS +CG G ++R V C +T C P C
Sbjct: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675
Query: 895 P---TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
P TW + W CS SCG G +RS++C+ + + C+ KP+E C
Sbjct: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQ--PSHLCHTDLKPEERKTC 1727
Score = 42.7 bits (99), Expect = 0.002
Identities = 19/50 (38%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC 890
A W G+WG CS SCG G+ +R+V C + Q + C +P E + C
Sbjct: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPS-HLCHTDLKPEERKTC 1727
Score = 36.6 bits (83), Expect = 0.11
Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 1/65 (1%)
Query: 513 HRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV-KYRSCNLEPCP 571
H + G+ + P+G CS TC GG Q C + E ++ + R+C PCP
Sbjct: 1325 HVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
Query: 572 SSASG 576
A G
Sbjct: 1385 QWAYG 1389
Score = 35.0 bits (79), Expect = 0.33
Identities = 33/132 (25%), Positives = 50/132 (37%), Gaps = 19/132 (14%)
Query: 504 CVERHNLNKHRVDGS-----WAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKY---- 554
CVER ++ R S WA + +G C++ CGGG++ C +NG ++
Sbjct: 1366 CVERIKPDEQRACESGPCPQWA-YGNWGECTKLCGGGIRTRLVVCQR---SNGERFPDLS 1421
Query: 555 CE--GVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSP 612
CE CN CP A+ + C G H V + K
Sbjct: 1422 CEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRN----VYCMAKDGSHLE 1477
Query: 613 RDKCKLICRANG 624
D CK + + +G
Sbjct: 1478 SDYCKHLAKPHG 1489
Score = 34.7 bits (78), Expect = 0.43
Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 3/62 (4%)
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNP--TPANGGKYCEGVRVKYRSCNLEPCPSSA 574
G W ++ + CS++C GG Q R C N + K +V + C+ PCP
Sbjct: 999 GGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWK 1057
Query: 575 SG 576
SG
Sbjct: 1058 SG 1059
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 726 bits (1874), Expect = 0.0
Identities = 377/820 (45%), Positives = 499/820 (60%), Gaps = 46/820 (5%)
Query: 1 MLLLGILTLAFAGRTAGGSEPEREVVVPIRLDPDINGRRYYWRGPEDSGDQGLIFQITAF 60
+LLL + +L + R A E E+V P +L+ + P L+ ++ AF
Sbjct: 37 LLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVL--------PGSGAPARLLCRLQAF 88
Query: 61 QEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAAVSLC 120
E L L D+ + ++LG + L G + +G +N +P+S A++
Sbjct: 89 GETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGT---YLTGTINGDPESVASLHWD 145
Query: 121 GG-LRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASG 179
GG L G YRGAE + PL + +A GAH+L+R+ P+ C V
Sbjct: 146 GGALLGVLQYRGAELHLQPLEGGTPNSA--GGPGAHILRRKS----PASGQGPMCNV--- 196
Query: 180 WNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLE 239
+A G R R RAKRF S+ R+VETLVVAD+ M FHGA L+
Sbjct: 197 ---------------KAPLGSPSPRPR--RAKRFASLSRFVETLVVADDKMAAFHGAGLK 239
Query: 240 HYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKL 299
YLLT++A AA+ ++HPSI NP+++VV ++++L + GP+V +AA TLR+FCAWQ+ L
Sbjct: 240 RYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGL 299
Query: 300 NKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTT 359
N D P+++DTAILFTRQDLCG +TCDTLGMADVGT+CDP RSC+++EDDGL SAFT
Sbjct: 300 NTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTA 359
Query: 360 AHELGHVFNMPHDNVKVCEEVFGKL-RANHMMSPTLIQIDRANPWSACSAAIITDFLDSG 418
AHELGHVFNM HDN K C + G L + H+M+P + +D PWS CSA ITDFLD+G
Sbjct: 360 AHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNG 419
Query: 419 HGDCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPYM-QYCTKLWCTGKAKGQ 477
+G CLLD+P P+ LP PG Y +QC+L FG S+ CP + C LWC+G G
Sbjct: 420 YGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGH 479
Query: 478 MVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVD--GSWAKWDPYGPCSRTCGGG 535
+CQT+H PWADGT CG + C+ G C+ L + G W W P+G CSRTCGGG
Sbjct: 480 AMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGG 539
Query: 536 VQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTN 595
VQ + R CT P P NGGKYCEG R ++RSCN E CP + S +FREEQC A+N
Sbjct: 540 VQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP-TGSALTFREEQCAAYNHRTDLFK 598
Query: 596 RLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCI 655
+ WVP+Y+GV+P+D+CKL C+A GY+YVL P+VVDGT CSPDS+SVCVQG+CI
Sbjct: 599 SFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCI 658
Query: 656 KAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRG 715
AGCD +GSKK+FDKC VCGGD C K +G F K +GYN VV IPAGA+ I +RQ+G
Sbjct: 659 HAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQG 718
Query: 716 YKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSL-LRYSGTGTAVESLQASRP 774
G YLALK G Y LNG + + D+V+ G++ LRYSG A E+L P
Sbjct: 719 NPG--HRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGP 776
Query: 775 ILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKD 814
+ +PLT++VL G R+RYSF++P+ P+D
Sbjct: 777 LAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQD 816
Score = 35.4 bits (80), Expect = 0.25
Identities = 18/52 (34%), Positives = 25/52 (48%), Gaps = 3/52 (5%)
Query: 846 GSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPT 896
G WG CS +CG G+Q + DC + C+ R ++C E CPT
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEG--RRTRFRSCNTEDCPT 576
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 694 bits (1792), Expect = 0.0
Identities = 370/935 (39%), Positives = 528/935 (56%), Gaps = 64/935 (6%)
Query: 55 FQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGL---TGGSSDLRRCFYSGDVNAEP 111
++ TA+ + F L+LT DA FLA ++ HLG P +G G SDLR CFY G VN++
Sbjct: 80 YRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQE 139
Query: 112 DSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGG------ 165
D A VSLCGGL G F + EY + P+ A + HL+ R+ +
Sbjct: 140 DYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLK 199
Query: 166 ---PSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGES----RSRRRSGRAKRFVSIPR 218
S + + L+ K R G + RR R KR +S PR
Sbjct: 200 YCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPR 259
Query: 219 YVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSG 278
Y+E +V AD +V HG++L++Y+LTL++ A +Y+ PSI N I+IVVVK++++ + G
Sbjct: 260 YIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEG 319
Query: 279 PKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATT-CDTLGMADVGT 337
P + + A TL+NFC+WQ+ N + D HP + DTA+L TR+D+C + C+ LG++ +GT
Sbjct: 320 PVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGT 379
Query: 338 MCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQI 397
+CDP +SC + E+ GL SAFT AHELGH + HD+ C+E+ K+ H+M+P L
Sbjct: 380 ICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEM--KVTKYHVMAPALSFH 437
Query: 398 DRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI-SLPEDLPGASYTLSQQCELAFGVGS 456
WS CS +T+FLD+G+G+CLLD+P + I +LP +LPG+ Y ++QCELAFG GS
Sbjct: 438 MSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGS 497
Query: 457 KPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVD 516
+ CP++ C LWCT K C T+H P ADGT CG G C G CV + + V+
Sbjct: 498 QMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRP-VN 556
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASG 576
G W W+PY CSRTCGGG++ A R+C P P NGG YC G R+K+RSCN + CP
Sbjct: 557 GEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGT-- 614
Query: 577 KSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVV 636
+ FRE+QC FNG + + + V W+P+YSG+ +D+CKL C+ GT YFY+L V
Sbjct: 615 QDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVE 674
Query: 637 DGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGY 696
DGT C ++ +CVQG+C+ AGCD L S + DKCGVCGGDN SCK +TG+F +GY
Sbjct: 675 DGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGY 734
Query: 697 NFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKG-- 754
N VV IPAGA+++DIRQ Y G DD+YLAL +++G +L NG+F++S ++++ V+G
Sbjct: 735 NVVVKIPAGATNVDIRQYSYSGQ-PDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTR 793
Query: 755 SLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKD 814
+++ YSG+ AVE + ++ + L ++VL VG + P V YSF +P E R D + D
Sbjct: 794 TVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTW--D 851
Query: 815 PRGP----------------SVLHNSVLSLSNQVEQPDDRPPA------------RWVAG 846
P GP + +H S S+ + E P+ RW
Sbjct: 852 PYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVI 911
Query: 847 SWGPCSASCGSGLQKRAVDC------RGSAGQRTVPACDAAHRPVETQACGEPC--PTWE 898
CS+ CG G + + C G Q C +P + C C W
Sbjct: 912 GKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWH 971
Query: 899 LSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQC 933
S WS CS+SCG G + R C+ + G LA ++C
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNEC 1006
Score = 102 bits (255), Expect = 1e-21
Identities = 55/149 (36%), Positives = 76/149 (51%), Gaps = 8/149 (5%)
Query: 809 SSHPKDPRGPSVLHNSVLSLSNQVEQPDDR---PPAR---WVAGSWGPCSASCGSGLQKR 862
S P P PS ++ L L+ ++E +++ P R W G WG CS+SC GLQ R
Sbjct: 1268 SHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHR 1327
Query: 863 AVDCRGSAGQRTVPACDAAHRPVETQACGE-PCPTWELSAWSPCSKSCGRGFQRRSLKCV 921
AV C+ GQ + CDAA +P E Q CG PCP W W CS++CG G + R + C
Sbjct: 1328 AVVCQDENGQ-SASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQ 1386
Query: 922 GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
G++L C + KP + C + C
Sbjct: 1387 FPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
Score = 82.0 bits (201), Expect = 2e-15
Identities = 34/110 (30%), Positives = 56/110 (50%), Gaps = 2/110 (1%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPTWELSA 901
W A W C +CG G ++R V C+ + + C+++ +P C C +W++
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGP 1084
Query: 902 WSPCSKSCGRGFQRRSLKCVGH-GGRLLARDQCNLHRKPQELDFCVLRPC 950
W PC+ +CG G+Q R +KCV +L +C+ +P + CVL PC
Sbjct: 1085 WGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 80.9 bits (198), Expect = 5e-15
Identities = 44/112 (39%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAH--RPVETQACGEPCPTWE 898
A+W GSW PCS SCG G Q R V CR A R AH RP E C PC W+
Sbjct: 1154 AQWRHGSWTPCSVSCGRGTQARYVSCR-DALDRIADESYCAHLPRPAEIWDCFTPCGEWQ 1212
Query: 899 LSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
WSPCS SCG G R + C+ + + + + C+ +P C L C
Sbjct: 1213 AGDWSPCSASCGHGKTTRQVLCMNY-HQPIDENYCDPEVRPLMEQECSLAAC 1263
Score = 73.2 bits (178), Expect = 1e-12
Identities = 41/138 (29%), Positives = 63/138 (45%), Gaps = 5/138 (3%)
Query: 813 KDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQ 872
+D G S + S +++Q P +W G+WG CS +CG G++ R V C+ GQ
Sbjct: 1332 QDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQ 1391
Query: 873 RTVPA-CDAAHRPVETQACG-EPCP---TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRL 927
C+ ++P C CP +W W+ CS SCG+G + R + C+ R
Sbjct: 1392 ILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRK 1451
Query: 928 LARDQCNLHRKPQELDFC 945
L C+ +KP C
Sbjct: 1452 LEDTNCSQVQKPPTHKAC 1469
Score = 71.2 bits (173), Expect = 4e-12
Identities = 44/132 (33%), Positives = 55/132 (41%), Gaps = 23/132 (17%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTV--PACDAAHRPVETQACG-EPC--- 894
A W G WGPC+ +CG G Q R V C + C A RP + Q+C PC
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
Query: 895 --------PT--------WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRK 938
PT W +W+PCS SCGRG Q R + C R+ C +
Sbjct: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPR 1197
Query: 939 PQELDFCVLRPC 950
P E+ C PC
Sbjct: 1198 PAEIWDC-FTPC 1208
Score = 69.7 bits (169), Expect = 1e-11
Identities = 41/114 (35%), Positives = 52/114 (45%), Gaps = 10/114 (8%)
Query: 842 RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVP-ACDAAHRPVETQACGE-PCPTWEL 899
RW W CS SCG G + R C + G R C R V + C E CP+W
Sbjct: 969 RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSR-VTRENCNEFSCPSWAA 1027
Query: 900 SAWSPCSKSCGRGFQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
S WS C +CG+G ++R + C V H L+ CN KP+ L C L C
Sbjct: 1028 SEWSECLVTCGKGTKQRQVWCQLNVDH----LSDGFCNSSTKPESLSPCELHTC 1077
Score = 65.1 bits (157), Expect = 3e-10
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 2/110 (1%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQACGEP-CPTWELS 900
W W CSASCG G + R V C ++ C +P +AC CP+W+ +
Sbjct: 1421 WHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKAN 1480
Query: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
+W+ CS +CG G Q+R + C G + + C+ +P C + C
Sbjct: 1481 SWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/155 (27%), Positives = 49/155 (31%), Gaps = 45/155 (29%)
Query: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCP-- 895
P W AG W PCSASCG G R V C CD RP+ Q C CP
Sbjct: 1207 PCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPA 1266
Query: 896 ----------------------------------------TWELSAWSPCSKSCGRGFQR 915
W W CS SC G Q
Sbjct: 1267 HSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQH 1326
Query: 916 RSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
R++ C G+ + C+ KP EL C PC
Sbjct: 1327 RAVVCQDENGQ--SASYCDAASKPPELQQCGPGPC 1359
Score = 47.4 bits (111), Expect = 6e-05
Identities = 39/149 (26%), Positives = 60/149 (40%), Gaps = 27/149 (18%)
Query: 820 VLHNSVLSLSNQVEQPDDRPPARW--VAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA 877
V ++S +SL+++ + PP + V C+ +CG ++R C +
Sbjct: 1570 VYNSSTISLTSKNCR---NPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKK--- 1623
Query: 878 CDAAHR--PVETQACG-----------EPC---PTWELSAWSPCSKSCGRGFQRRSLKCV 921
HR P+ Q C C TW++ WS CS +CG G +R +KC+
Sbjct: 1624 -HKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI 1682
Query: 922 GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
G L+ D C H KP C C
Sbjct: 1683 TKHG--LSSDLCLNHLKPGAQKKCYANDC 1709
Score = 34.3 bits (77), Expect = 0.57
Identities = 85/349 (24%), Positives = 117/349 (33%), Gaps = 102/349 (29%)
Query: 399 RANPWSACSAAIITDFLDSGHG----DCLLDQPSKPISLPEDLPGASYTLSQQCELAF-- 452
+A WS CSA+ GHG L +PI P + Q+C LA
Sbjct: 1212 QAGDWSPCSASC-------GHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
Query: 453 ----GVGSKPC-PYMQYCTKLWCTGKAK---GQMVC------QTRHFPWAD-GTSCGEGK 497
S P P T L T K + Q+V Q R PW +SC G
Sbjct: 1265 PAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGL 1324
Query: 498 LCLKGACVERHNLNKHRVD-------------GSWAKWD--PYGPCSRTCGGGVQLARRQ 542
C + + + D G +W+ +G CS+TCGGG++
Sbjct: 1325 QHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVI 1384
Query: 543 CTNPTPANG----GKYCEGVR--VKYRSCNLEPCPSSAS---------------GKSFRE 581
C P NG CE V C++ CP+ S G+ +RE
Sbjct: 1385 CQFP---NGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYRE 1441
Query: 582 EQC-EAFNGYNHSTN-------------RLTLAVAW---------VPKYSGVSPRDKCKL 618
C + F TN R +W V SGV RD +
Sbjct: 1442 VFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRD---V 1498
Query: 619 ICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKK 667
CR G G +VV+ +C ST C Q +C C + G ++
Sbjct: 1499 YCRLKGVG-------QVVE-EMCD-QSTRPCSQRRCWSQDCVQHKGMER 1538
Score = 33.5 bits (75), Expect = 0.97
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 520 AKWD--PYGPCSRTCGGGVQLARRQCTNPTPA---NGGKYCEGVRVKYR-SCNLEPC 570
A W P+GPC+ TCG G Q+ +C N + + E R R SC L PC
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 31.2 bits (69), Expect = 4.8
Identities = 18/58 (31%), Positives = 27/58 (46%), Gaps = 2/58 (3%)
Query: 522 WDPYGPCSRTCGGGVQLARRQCTNPTPAN-GGKYCEGV-RVKYRSCNLEPCPSSASGK 577
+ + CSR+CGGG + C N C+ + RV +CN CPS A+ +
Sbjct: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASE 1029
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 691 bits (1784), Expect = 0.0
Identities = 361/814 (44%), Positives = 471/814 (57%), Gaps = 42/814 (5%)
Query: 101 CFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPL---PNASAPAAQRNSQGA--- 154
CFY G V+ P S A LCGGL G F + A Y + PL P A + G+
Sbjct: 130 CFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARI 189
Query: 155 -HLLQRRGVP----------GGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGF---GE 200
H+ R G P+ P + + NP+ AL ++ G
Sbjct: 190 LHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAGG 249
Query: 201 SRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILN 260
S + R +R +S R VE L+VAD SM + +G L+HYLLTL + A RLY H SI N
Sbjct: 250 SGPQTWWRRRRRSISRARQVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHASIEN 309
Query: 261 PINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQD 320
I + VVKV++L D+D +V+ NAA TL+NFC WQ + N++ D H E++D AILFTR+D
Sbjct: 310 HIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTRED 369
Query: 321 LCGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEV 380
LCG +CDTLGMADVGT+C P+RSC+VIEDDGL +AFT AHE+GH+ + HD+ K CEE
Sbjct: 370 LCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEET 429
Query: 381 FGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGA 440
FG +MS L ID + PWS C++A IT+FLD GHG+CLLD P K I PE+LPG
Sbjct: 430 FGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQ 489
Query: 441 SYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCL 500
+Y +QQC L FG CP M C +LWC +GQMVC T+ P +GT CG+G++CL
Sbjct: 490 TYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICL 549
Query: 501 KGACVERHNLNKHRVD--GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGV 558
+G CV++ + G+W W +G CSR+CGGGVQ A R C NP P N G+YC G
Sbjct: 550 QGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGK 609
Query: 559 RVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKL 618
R YRSC+L PCP +GKSFR EQCEA NGY + V WVPKY+GV P D CKL
Sbjct: 610 RAIYRSCSLMPCP--PNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKL 667
Query: 619 ICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGD 678
CRA GTGY+ V +PKV DGT C S SVCV+GKC++ GCDG +GSK ++DKCGVCGGD
Sbjct: 668 TCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGD 727
Query: 679 NKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLN 738
N SC K+ G F K GY VV IP GA+ I +RQ K YLALK G+YL+N
Sbjct: 728 NSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLIN 787
Query: 739 GHFVVSAVERDLVVKGSLLRYSGTGTAVESLQAS--RPILEPLTVEVLSVGKMTPPRVRY 796
G +++S E + + G+++ YSG + L E L V++L+ P VRY
Sbjct: 788 GKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRY 847
Query: 797 SFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCG 856
SF++PK+ P+ SV + + + QP +WV G W CS +C
Sbjct: 848 SFFVPKK---------STPKVNSVTSHGSNKVGSHTSQP------QWVTGPWLACSRTCD 892
Query: 857 SGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC 890
+G R V C+ ++ C + RP + C
Sbjct: 893 TGWHTRTVQCQ-DGNRKLAKGCPLSQRPSAFKQC 925
Score = 42.0 bits (97), Expect = 0.003
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 895 PTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
P W W CS++C G+ R+++C G R LA+ C L ++P C+L+ C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQC-QDGNRKLAKG-CPLSQRPSAFKQCLLKKC 930
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif,
7 preproprotein [Homo sapiens]
Length = 1686
Score = 488 bits (1255), Expect = e-137
Identities = 363/1001 (36%), Positives = 477/1001 (47%), Gaps = 120/1001 (11%)
Query: 1 MLLLGILTLAFAGRTAGGSEPER---EVVVPIRLDPDINGRRY-YWRGPEDSGDQGLIFQ 56
+LLL L G G + R ++V P+R+D + Y W D +
Sbjct: 18 LLLLCALAPGAPGPAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRD 77
Query: 57 ITAFQEDFY------LHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAE 110
AF E Y +LT + LAP F +E G + C G+V +
Sbjct: 78 APAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQ-D 136
Query: 111 PD---SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPG--- 164
P+ AA+S C GL+G F +Y I PL SAPA ++Q H++ +R P
Sbjct: 137 PELEGGLAAISACDGLKGVFQLSNEDYFIEPLD--SAPARPGHAQ-PHVVYKRQAPERLA 193
Query: 165 --GPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRF----VSIPR 218
G S P S CGV + P R E R + R R +R VS +
Sbjct: 194 QRGDSSAP-STCGVQ----------VYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEK 242
Query: 219 YVETLVVADESMVKFHGA-DLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDS 277
+VETLVVAD MV++HG +E Y+LT++ A L+ PSI NPI+I +V+++LL D +
Sbjct: 243 WVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEE 302
Query: 278 GPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATT--CDTLGMADV 335
K+T +A TL++FC WQK +N D HP + DTAIL TR+DLC A C+TLG++ V
Sbjct: 303 DLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHV 362
Query: 336 GTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLI 395
MC P RSCS+ ED GLP AFT AHELGH F + HD E GK +MSP L+
Sbjct: 363 AGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGK--RPFIMSPQLL 420
Query: 396 QIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI-SLPEDLPGASYTLSQQCELAFGV 454
WS CS IT FLD G G CL D P+K I P PG Y +S QC L +G
Sbjct: 421 YDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGA 480
Query: 455 GSKPCPYMQ-YCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKH 513
S C M C LWC+ C ++ DGT CGE K CL G CV
Sbjct: 481 YSAFCEDMDNVCHTLWCSVGT----TCHSKLDAAVDGTRCGENKWCLSGECVPV-GFRPE 535
Query: 514 RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSS 573
VDG W+ W + CSR+CG GVQ A RQCT PTP G+YC G R ++R CNL+ CP
Sbjct: 536 AVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACP-- 593
Query: 574 ASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAP 633
A SFR QC F+ + T WVP + V+P C+L CR + L
Sbjct: 594 AGRPSFRHVQCSHFDAMLYKGQLHT----WVPVVNDVNP---CELHCRPANEYFAEKLRD 646
Query: 634 KVVDGTLCSP--DSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK 691
VVDGT C S +C+ G C GCD + S D+CGVC G+ +C V+G F +
Sbjct: 647 AVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEE 706
Query: 692 PMH-GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQG-KYLLNGHFVVSAVERD 749
GY V IPAGA I I++ N+LAL++ KY LNG + + D
Sbjct: 707 AEGLGYVDVGLIPAGAREIRIQEVAEAA-----NFLALRSEDPEKYFLNGGWTIQW-NGD 760
Query: 750 LVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKS 809
V G+ Y+ G E+L + P EP+ +++L + + P V Y + + +E
Sbjct: 761 YQVAGTTFTYARRGNW-ENLTSPGPTKEPVWIQLLF--QESNPGVHYEYTIHREA----G 813
Query: 810 SHPKDPR-----------------GPSVLHNSVLSLSNQ-----------VEQPDDRP-- 839
H + P G V +V L Q + +PDD+
Sbjct: 814 GHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRK 873
Query: 840 ------PARWVAGSWGPCSASCG-SGLQKRAVDCRGSAG-----QRTVPACDAAHRPVET 887
PARW AG W CS+SCG GL +RAV C S G PAC+ RP
Sbjct: 874 CSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTE 933
Query: 888 QACGE--PCP-TWELSAWSPCSKSCGRGFQRRSLKCVGHGG 925
C PCP TW + WS CS +CG G QRR++ C G
Sbjct: 934 TPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG 974
Score = 72.0 bits (175), Expect = 2e-12
Identities = 41/116 (35%), Positives = 49/116 (42%), Gaps = 9/116 (7%)
Query: 838 RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPT 896
+P W SW CS +CG G Q+R V C C+ A RP T+ C PC
Sbjct: 1519 QPCLSWYTSSWRECSEACGGGEQQRLVTCPEPG------LCEEALRPNTTRPCNTHPCTQ 1572
Query: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLAR--DQCNLHRKPQELDFCVLRPC 950
W + W CS CG G QRR +KCV L DQC P+ C C
Sbjct: 1573 WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 71.6 bits (174), Expect = 3e-12
Identities = 43/122 (35%), Positives = 55/122 (45%), Gaps = 21/122 (17%)
Query: 838 RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTV--------PACDAAHRPVETQA 889
RP A W +G+W CS SCG G R V C + R + PA AHRP
Sbjct: 1461 RPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRP----- 1515
Query: 890 CG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLR 948
CG +PC +W S+W CS++CG G Q+R + C G C +P C
Sbjct: 1516 CGAQPCLSWYTSSWRECSEACGGGEQQRLVTCPEPG-------LCEEALRPNTTRPCNTH 1568
Query: 949 PC 950
PC
Sbjct: 1569 PC 1570
Score = 67.0 bits (162), Expect = 8e-11
Identities = 33/82 (40%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPTWEL 899
A W AG+W CS +CG G R V C + PA RP + C PC TW
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPA----GRPQPARRCHLRPCATWHS 1468
Query: 900 SAWSPCSKSCGRGFQRRSLKCV 921
WS CS+SCG G R ++CV
Sbjct: 1469 GNWSKCSRSCGGGSSVRDVQCV 1490
Score = 55.5 bits (132), Expect = 2e-07
Identities = 27/71 (38%), Positives = 31/71 (43%), Gaps = 4/71 (5%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWEL 899
PA W G+W CS +CG G Q+R V C G VP CD A +P C P W L
Sbjct: 943 PATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG---VP-CDEAQQPASEVTCSLPLCRWPL 998
Query: 900 SAWSPCSKSCG 910
P G
Sbjct: 999 GTLGPEGSGSG 1009
Score = 45.4 bits (106), Expect = 2e-04
Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 16/81 (19%)
Query: 830 NQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQA 889
N + P +WV G WG CS CG G+Q+R V C + Q +P D +
Sbjct: 1560 NTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNT--QTGLPEED-------SDQ 1610
Query: 890 CGEPCPTWELSAWSPCSKSCG 910
CG AW S+ CG
Sbjct: 1611 CGH-------EAWPESSRPCG 1624
Score = 38.9 bits (89), Expect = 0.023
Identities = 17/59 (28%), Positives = 30/59 (50%), Gaps = 1/59 (1%)
Query: 893 PCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCN-LHRKPQELDFCVLRPC 950
P +W W+ C+ +CGRG QR+++ C+ + + C+ L R + C +PC
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPC 879
Score = 33.1 bits (74), Expect = 1.3
Identities = 34/129 (26%), Positives = 47/129 (36%), Gaps = 30/129 (23%)
Query: 455 GSKPCPYMQYCTKLW------CTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERH 508
G++PC + + T W C G + ++V +C E LC + R
Sbjct: 1517 GAQPC--LSWYTSSWRECSEACGGGEQQRLV------------TCPEPGLCEEAL---RP 1559
Query: 509 NLNKHRVDGSWAKW--DPYGPCSRTCGGGVQLARRQCTNP---TPANGGKYC--EGVRVK 561
N + +W P+G CS CGGGVQ +C N P C E
Sbjct: 1560 NTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPES 1619
Query: 562 YRSCNLEPC 570
R C E C
Sbjct: 1620 SRPCGTEDC 1628
Score = 31.6 bits (70), Expect = 3.7
Identities = 19/61 (31%), Positives = 29/61 (47%), Gaps = 11/61 (18%)
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGK--YCEGVRVK---YRSCNLEPCP 571
G+W+K CSR+CGGG + QC + + +C+ K +R C +PC
Sbjct: 1469 GNWSK------CSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCL 1522
Query: 572 S 572
S
Sbjct: 1523 S 1523
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 481 bits (1239), Expect = e-135
Identities = 336/1008 (33%), Positives = 471/1008 (46%), Gaps = 114/1008 (11%)
Query: 24 EVVVPIRLDP-----------DINGRRYYWRGPEDSGD--QGLIFQITAFQEDFYLHLTP 70
++ +PIR+D D + RR P D L F+++A+ + F+L+LT
Sbjct: 43 QLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTL 102
Query: 71 DAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSF-AAVSLCGGLRGAFGY 129
+ F++ F+ E+ G G L C Y+G + + + A+S C GL G
Sbjct: 103 NTDFVSKHFTVEYWGK--DGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVIAT 160
Query: 130 RGAEYVISPLPNASAPAAQRNSQGA--HLLQRRGVPGGPSGDPTSRCGVASGWNPAILRA 187
EY I PL N + + + + H++ ++ S CGV+
Sbjct: 161 EDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFTRSGKPWW 220
Query: 188 LDPYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHG-ADLEHYLLTLL 246
L+ + + R KR VSI R+VETLVVAD+ MV +HG D+EHY+L+++
Sbjct: 221 LNDTSTVSYSLPINNTHIHH-RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVM 279
Query: 247 ATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKL------- 299
A+LYR S+ N +NI+V ++++L + ++ +A +L +FC WQK +
Sbjct: 280 NIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDG 339
Query: 300 NKVSDKHPEYWDTAILFTRQDLCGATT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAF 357
N + + + D A+L TR D+C C TLG+A V MC+P+RSCS+ ED GL SAF
Sbjct: 340 NTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAF 399
Query: 358 TTAHELGHVFNMPHDNVKVCEEVFG----KLRANHMMSPTLIQIDRANP--WSACSAAII 411
T AHE+GH F M HD + G KL A H+ + T NP WSACS I
Sbjct: 400 TIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANT-------NPFSWSACSRDYI 452
Query: 412 TDFLDSGHGDCLLDQPSKPISL-PEDLPGASYTLSQQCELAFGVGSKPCPYMQYCTKLWC 470
T FLDSG G CL ++P K L P PG Y +QC +G S+ C Y + C +LWC
Sbjct: 453 TSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWC 512
Query: 471 TGKAKGQMVCQTRHFPWADGTSCGEGKL----CLKGACVERHNLNKHRVDGSWAKWDPYG 526
K+ C T P A+GT C G + C +G CV +DG W W +G
Sbjct: 513 LSKSNR---CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVP-FGTWPQSIDGGWGPWSLWG 568
Query: 527 PCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEA 586
CSRTCGGGV + R C +P P+ GGKYC G R +YRSCN +PCP + FRE+QC
Sbjct: 569 ECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCP--LGSRDFREKQCAD 626
Query: 587 FNGYNHSTNRLTLAVAWVP-KYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDS 645
F+ W P GV P C L C A G ++ AP V+DGT C+ DS
Sbjct: 627 FDNMPFRGKYYN----WKPYTGGGVKP---CALNCLAEGYNFYTERAPAVIDGTQCNADS 679
Query: 646 TSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLF--TKPMHGYNFVVAIP 703
+C+ G+C GCD LGS R D+C VCGGD +C + G F + P GY VV IP
Sbjct: 680 LDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIP 739
Query: 704 AGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTG 763
G+ I++R+ + NY+ALK+ Y +NG + + R V G+ Y
Sbjct: 740 RGSVHIEVRE-----VAMSKNYIALKSEGDDYYINGAWTID-WPRKFDVAGTAFHYKRPT 793
Query: 764 TAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLP----------------KEPRED 807
ESL+A P E L V VL + +RY F +P +P +
Sbjct: 794 DEPESLEALGPTSENLIVMVLLQEQNL--GIRYKFNVPITRTGSGDNEVGFTWNHQPWSE 851
Query: 808 KSS------HPKDPRGPSVLHNSVLSLSNQVEQPDDRP------------PARWVAGSWG 849
S+ ++ + NS+ + N PD +P P W G W
Sbjct: 852 CSATCAGGVQRQEVVCKRLDDNSI--VQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWL 909
Query: 850 PCSASCGSGLQKRAVDCRGSAGQRTVPACD----AAHRPVETQAC-GEPC-PTWELSAWS 903
CS +C G++ RAV C G D HRPVE + C + C P W WS
Sbjct: 910 ECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWVALDWS 969
Query: 904 PCSKSCGRGFQRRSLKCVGHG-GRLLARDQCNLHRKPQELDFCVLRPC 950
C+ CG GF+ R + C + QC KP C L C
Sbjct: 970 ECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRC 1017
Score = 67.0 bits (162), Expect = 8e-11
Identities = 36/111 (32%), Positives = 50/111 (45%), Gaps = 7/111 (6%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRPVETQACGE---PC 894
P +WVA W C+ CG G + R V C+ S +T PA C +P C P
Sbjct: 960 PPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP 1019
Query: 895 PTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
P W W CS CG G Q R+++C+ + G+ A C +P + C
Sbjct: 1020 PRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQ--ASSDCLETVRPPSMQQC 1068
Score = 59.3 bits (142), Expect = 2e-08
Identities = 35/101 (34%), Positives = 40/101 (39%), Gaps = 17/101 (16%)
Query: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPCPTWE 898
PP RWV G WG CSA CG G Q R V C GQ + C RP Q C C +
Sbjct: 1018 PPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS-SDCLETVRPPSMQQCESKCDSTP 1076
Query: 899 LSAWSPCS--------------KSCGRGFQRRSL--KCVGH 923
+S C K C R + R+ C GH
Sbjct: 1077 ISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTCQGH 1117
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 468 bits (1205), Expect = e-132
Identities = 326/911 (35%), Positives = 438/911 (48%), Gaps = 98/911 (10%)
Query: 43 RGPEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCF 102
RG + + L +++ + F L+LT ++ LA S E+ +GL + C
Sbjct: 66 RGTGATAESRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYW--TREGLAWQRAARPHCL 123
Query: 103 YSGDVNAEPD-SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRG 161
Y+G + + S A+S CGGL G EY+I PL + G H++ +R
Sbjct: 124 YAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRS 183
Query: 162 VPGGPSGDPTSRCGVASG--WN--PAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIP 217
P D + CGV W P LR L P R G + + R KR VS
Sbjct: 184 SLRHPHLD--TACGVRDEKPWKGRPWWLRTLKPPPARPLG---NETERGQPGLKRSVSRE 238
Query: 218 RYVETLVVADESMVKFHGA-DLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRD 276
RYVETLVVAD+ MV +HG D+E Y+L ++ A+L++ S+ + +NI+V +++LL +
Sbjct: 239 RYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQ 298
Query: 277 SGPKVTGNAALTLRNFCAWQKKL-------NKVSDKHPEYWDTAILFTRQDLC--GATTC 327
++T +A +L +FC WQK + N + + DTA+L TR D+C C
Sbjct: 299 PTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPC 358
Query: 328 DTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFG----K 383
TLG+A VG MC+ +RSCSV ED GL +AFT AHE+GH F M HD V G K
Sbjct: 359 GTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAK 418
Query: 384 LRANHMMSPTLIQIDRANP--WSACSAAIITDFLDSGHGDCLLDQPSKP-ISLPEDLPGA 440
L A H+ T NP WS+CS IT FLDSG G CL ++P + P PG
Sbjct: 419 LMAAHITMKT-------NPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQ 471
Query: 441 SYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKL-- 498
+Y +QC GV S+ C Y + C++LWC K+ C T P A+GT C +
Sbjct: 472 AYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNR---CITNSIPAAEGTLCQTHTIDK 528
Query: 499 --CLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCE 556
C K CV VDG+W W P+G CSRTCGGGV + R C +P P GGKYC
Sbjct: 529 GWCYKRVCVP-FGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCL 587
Query: 557 GVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKC 616
G R ++RSCN + CP + + FRE QC F+ W Y G + C
Sbjct: 588 GERRRHRSCNTDDCPPGS--QDFREVQCSEFDSIPFRGK----FYKW-KTYRGGGVK-AC 639
Query: 617 KLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCG 676
L C A G ++ A VVDGT C PD+ +CV G+C GCD LGS R DKC VCG
Sbjct: 640 SLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCG 699
Query: 677 GDNKSCKKVTGLFT--KPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGK 734
GD +C+ + G+F+ P GY VV IP G+ I I+ L ++LALK Q
Sbjct: 700 GDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQD-----LNLSLSHLALKGDQES 754
Query: 735 YLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRV 794
LL G R L + G+ + V+SL+A PI L V VL+ ++ P +
Sbjct: 755 LLLEGLPGTPQPHR-LPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTEL--PAL 811
Query: 795 RYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSAS 854
RY F P D PP W W CSA
Sbjct: 812 RYRFNAP-------------------------------IARDSLPPYSWHYAPWTKCSAQ 840
Query: 855 CGSGLQKRAVDCRGSAGQRTV-PACDAAHR--PVETQACG-EPC-PTWELSAWSPCSKSC 909
C G Q +AV+CR V P +AH P +AC EPC P W + WS CS+SC
Sbjct: 841 CAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSC 900
Query: 910 GRGFQRRSLKC 920
G + RS+ C
Sbjct: 901 DAGVRSRSVVC 911
Score = 73.2 bits (178), Expect = 1e-12
Identities = 38/111 (34%), Positives = 52/111 (46%), Gaps = 7/111 (6%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRPVETQACG-EPCP- 895
P W A W C+ SCG GL+ R V C+ + + T+P C A +P T C CP
Sbjct: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
Query: 896 -TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
W W CS CG G ++RS++C H G+ A +C +P C
Sbjct: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQ--ASHECTEALRPPTTQQC 1053
Score = 62.8 bits (151), Expect = 1e-09
Identities = 29/56 (51%), Positives = 33/56 (58%), Gaps = 1/56 (1%)
Query: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPC 894
PPARWVAG WG CSA CG G ++R+V C GQ + C A RP TQ C C
Sbjct: 1003 PPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQAS-HECTEALRPPTTQQCEAKC 1057
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 460 bits (1184), Expect = e-129
Identities = 331/1034 (32%), Positives = 467/1034 (45%), Gaps = 138/1034 (13%)
Query: 16 AGGSEPEREVVVPIRLDP-------DI--NGRRYYWRGPEDSGDQGLIFQITAFQEDFYL 66
A G + V P+ +D DI NGR+ + + L ++ +AF ++ +L
Sbjct: 54 ASGLNDDYVFVTPVEVDSAGSYISHDILHNGRK---KRSAQNARSSLHYRFSAFGQELHL 110
Query: 67 HLTPDAQFLAPAFSTEHLGVPLQGLTGGSS----DLRRCFYSGDVNAEPDSFAAVSLCGG 122
L P A + H V + G G S ++++CFY G + + S AVS C G
Sbjct: 111 ELKPSA------ILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAG 164
Query: 123 LRGAFGYRGAEYVISPLPNASAPAAQRNSQGAH-------------LLQRRGVPGG---- 165
L G R E++ISPLP A +S H + + RG PG
Sbjct: 165 LSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNY 224
Query: 166 ----PSGDPTSRCGVASGWNPAILRALD------PYKP---------RRAGFGES-RSRR 205
PS P + + ++ L+ Y P R +G S R RR
Sbjct: 225 PGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRR 284
Query: 206 RSGRAKRFVSIPRYVETLVVADESMVKFHG-ADLEHYLLTLLATAARLYRHPSILNPINI 264
+G++++ ++ VETLVVAD+ MV+ HG ++ Y+LT++ + L++ +I + IN+
Sbjct: 285 SAGKSQKGLN----VETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINV 340
Query: 265 VVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGA 324
VVV ++LL G + +A +L +FC WQ L K+ + D AIL T D+C
Sbjct: 341 VVVSLILLEQEPGGLLINHHADQSLNSFCQWQSAL---IGKNGKRHDHAILLTGFDICSW 397
Query: 325 TT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNV-KVCEEVF 381
CDTLG A + MC RSC++ ED GL AFT AHE GH F M HD C +
Sbjct: 398 KNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAE 457
Query: 382 GKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKP--ISLPEDLPG 439
G + MSPTL + WS+CS + FL + CL+D+P + P+ LPG
Sbjct: 458 GNI-----MSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPG 512
Query: 440 ASYTLSQQCELAFGVGSKPCPY---MQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEG 496
Y QC+ FG +K C C LWC C+T+ P A+GT CG
Sbjct: 513 QIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR---CETKFMPAAEGTVCGLS 569
Query: 497 KLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCE 556
C +G CV+ L + G W+ W + CSRTCGGGV+ R C NP P GG +C
Sbjct: 570 MWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCP 629
Query: 557 GVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKC 616
G Y+ CN+ PC + + FR +QC +N S W P Y+ V D+C
Sbjct: 630 GSSRIYQLCNINPC--NENSLDFRAQQCAEYN----SKPFRGWFYQWKP-YTKVEEEDRC 682
Query: 617 KLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCG 676
KL C+A +F+ ++ KV DGT CSP+ VC+ G C GCD LGSK D CGVC
Sbjct: 683 KLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCK 742
Query: 677 GDNKSCKKVTGLFTK--PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGK 734
GDN +CK GL+ + Y VV IPAGA SI+I++ L +YLA+++ K
Sbjct: 743 GDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQE-----LQVSSSYLAVRSLSQK 797
Query: 735 YLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRV 794
Y L G + + + G+ Y + E L A P E L E+L GK P +
Sbjct: 798 YYLTGGWSID-WPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGK--NPGI 854
Query: 795 RYSFYLPK----EPREDK---------SSHPKDPRGPSVLHNSVLSLSNQVEQ------- 834
+ + LPK P K S G ++ + L +Q Q
Sbjct: 855 AWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCS 914
Query: 835 ----PDDRP--------PARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPAC 878
P P PA W+ G W CS +C G Q R + C + + +
Sbjct: 915 AKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSL 974
Query: 879 DAAHRPVETQACGEPC--PTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLH 936
P + QAC P W L WS CSK+CGRG ++R L C G L QC
Sbjct: 975 CPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSL 1034
Query: 937 RKPQELDFCVLRPC 950
+P+ + CVL C
Sbjct: 1035 PRPELQEGCVLGRC 1048
Score = 64.7 bits (156), Expect = 4e-10
Identities = 43/126 (34%), Positives = 56/126 (44%), Gaps = 20/126 (15%)
Query: 842 RWVAGSWGPCSASCGSGLQKRAVDC--RGSAGQR-TVP--ACDAAHRP---VETQACGEP 893
+WVA SW CSA+CG G++KR + C +G G+ T P C +P +E
Sbjct: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRA 1114
Query: 894 CPT---------WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDF 944
CP W W C+ +CG G Q RS+ CV G C LH+KP L
Sbjct: 1115 CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQG---RPSSSCLLHQKPPVLRA 1171
Query: 945 CVLRPC 950
C C
Sbjct: 1172 CNTNFC 1177
Score = 37.0 bits (84), Expect = 0.087
Identities = 50/190 (26%), Positives = 66/190 (34%), Gaps = 28/190 (14%)
Query: 402 PWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPY 461
PWS CS G G + K S E LP + T + EL G CP
Sbjct: 999 PWSQCSKTC-------GRGVRKRELLCKG-SAAETLPESQCTSLPRPELQEGCVLGRCPK 1050
Query: 462 ---MQYCTKLW--CT-----GKAKGQMVCQTRHF-------PWADGTSCGEGKLCLKGAC 504
+Q+ W C+ G K +M C + F P + + L L+ C
Sbjct: 1051 NSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
Query: 505 VERHNLNKHRVDGSWAKWD--PYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKY 562
R H V A W P+ C+ TCGGGVQ C +
Sbjct: 1111 -NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVL 1169
Query: 563 RSCNLEPCPS 572
R+CN CP+
Sbjct: 1170 RACNTNFCPA 1179
Score = 34.3 bits (77), Expect = 0.57
Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP-CPTWE 898
A W + W C+ +CG G+Q R+V C R +C +P +AC CP E
Sbjct: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQQG--RPSSSCLLHQKPPVLRACNTNFCPAPE 1181
Score = 30.4 bits (67), Expect = 8.2
Identities = 53/230 (23%), Positives = 76/230 (33%), Gaps = 71/230 (30%)
Query: 492 SCGEGKLCLKGACVERHNLNKHRVDGSW--------------------AKWDP--YGPCS 529
SCG G + +K C+ N +V+ S+ A W P + CS
Sbjct: 888 SCGGGYINVKAICLRDQNT---QVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCS 944
Query: 530 RTCGGGVQLARRQCTNPTP-----ANGGKYCE-GVRVKYRSCNLEPCPSSASGKSFREEQ 583
+ C GG Q + QC P A C + ++CN CP S + Q
Sbjct: 945 KACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPW--SQ 1002
Query: 584 CEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSP 643
C G GV R+ L+C+ + P+ +L P
Sbjct: 1003 CSKTCG------------------RGVRKRE---LLCKGSAA----ETLPESQCTSLPRP 1037
Query: 644 DSTSVCVQGKCIK-----------AGCDG--NLGSKKRFDKCGVCGGDNK 680
+ CV G+C K + C LG +KR KC G K
Sbjct: 1038 ELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGK 1087
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 456 bits (1174), Expect = e-128
Identities = 320/989 (32%), Positives = 478/989 (48%), Gaps = 101/989 (10%)
Query: 21 PEREVVVPIRLDPDINGRRYYWRGPE---------DSGDQGLIFQITAFQEDFYLHLTPD 71
PE VV P+R+D + Y P D + + ++I+ ++D + +LT +
Sbjct: 50 PEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVN 109
Query: 72 AQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSF--AAVSLCGGLRGAFGY 129
FL+ ++ E L + +S C SG V + AA+S C GL G F
Sbjct: 110 QGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQL 169
Query: 130 RGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALD 189
++ I P+ P + + +R+ VP + +PT CG+ N + + L
Sbjct: 170 PHGDFFIEPVKKH--PLVEGGYHPHIVYRRQKVP--ETKEPT--CGLKDSVNISQKQELW 223
Query: 190 PYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLAT 248
K R RRS +S R+VETLVVAD M+++HG++ +E Y+LT++
Sbjct: 224 REKWERHNLPSRSLSRRS------ISKERWVETLVVADTKMIEYHGSENVESYILTIMNM 277
Query: 249 AARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPE 308
L+ +PSI N I+IVVV+++LL + + G K+ +A TL +FC WQK +N SD +P
Sbjct: 278 VTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPV 337
Query: 309 YWDTAILFTRQDLCGATT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHV 366
+ D A+L TR+D+C C+TLG++ + MC P RSC++ ED GLP AFT AHELGH
Sbjct: 338 HHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHS 397
Query: 367 FNMPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQ 426
F + HD + E G R ++MS L WS CS IT FLD G G CL D
Sbjct: 398 FGIQHDGKENDCEPVG--RHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDI 455
Query: 427 PSKP-ISLPEDLPGASYTLSQQCELAFGVGSKPCPYMQ-YCTKLWCTGKAKGQMVCQTRH 484
P K + PG Y + QC+L +G + C ++ C LWC+ K C+++
Sbjct: 456 PKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCSVKG----FCRSKL 511
Query: 485 FPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCT 544
ADGT CGE K C+ G C+ + G W +W P+ CSRTCG GVQ A R C
Sbjct: 512 DAAADGTQCGEKKWCMAGKCITVGK-KPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCN 570
Query: 545 NPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWV 604
NP P GGKYC G R +YR CN+ PC S A +FR+ QC F+ + W
Sbjct: 571 NPEPKFGGKYCTGERKRYRLCNVHPCRSEA--PTFRQMQCSEFDTVPYKNE----LYHWF 624
Query: 605 PKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLC--SPDSTSVCVQGKCIKAGCDGN 662
P + +P C+L CR + + V+DGT C +S +VC+ G C GCD
Sbjct: 625 PIF---NPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYE 681
Query: 663 LGSKKRFDKCGVCGGDNKSCKKVTGLF-TKPMHGYNFVVAIPAGASSIDIRQRGYKGLIG 721
+ S D+CGVC GD SC+ V +F K GY + IP GA I + + + G
Sbjct: 682 IDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVME-----IEG 736
Query: 722 DDNYLALKNSQ-GKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLT 780
N+LA+++ KY LNG F++ + + G++ +Y G +E L A+ P E +
Sbjct: 737 AGNFLAIRSEDPEKYYLNGGFIIQ-WNGNYKLAGTVFQYDRKGD-LEKLMATGPTNESVW 794
Query: 781 VEVLSVGKMTPPRVRYSFYLPKEPREDKSSHP------------KDPRGPSVLHNSV--- 825
+++L ++T P ++Y + + K+ ++ G + +
Sbjct: 795 IQLLF--QVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCI 852
Query: 826 --------LSLSNQVEQPDDRP--------PARWVAGSWGPCSASCG-SGLQKRAVDCRG 868
+ + QP+ R P RW AG W CSA+CG G +KR V C
Sbjct: 853 KKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQ 912
Query: 869 S--AGQRTVPACDAAH--RPVETQACGEP--CPT-WELSAWSPCSKSCGRGFQRRSLKCV 921
+ + ++ +P D H +P +C CP+ W + WS CS SCG G + RS+ C
Sbjct: 913 TMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCA 972
Query: 922 GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
+ + C++ RKP C L+ C
Sbjct: 973 KNHD-----EPCDVTRKPNSRALCGLQQC 996
Score = 82.4 bits (202), Expect = 2e-15
Identities = 42/108 (38%), Positives = 53/108 (49%), Gaps = 9/108 (8%)
Query: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP-CPTW 897
P W W CS SCG G+Q+R V C G CD RP T +C E C W
Sbjct: 1423 PCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL-------CDWTKRPTSTMSCNEHLCCHW 1475
Query: 898 ELSAWSPCSKSCGRGFQRRSLKCV-GHGGRLLARDQCNLHRKPQELDF 944
W CS SCG GFQ+R+++CV G + +DQC KP+ +F
Sbjct: 1476 ATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF 1523
Score = 76.3 bits (186), Expect = 1e-13
Identities = 43/140 (30%), Positives = 65/140 (46%), Gaps = 14/140 (10%)
Query: 800 LPKEPREDKSSHP---KDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCG 856
LP + KSS P ++ + +L+ SN + + A W+ G+W CS +CG
Sbjct: 1271 LPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCG 1330
Query: 857 SGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPTWELSAWSPCSKSCGRGFQR 915
G R V+C + C A RP + C PC W++ WS CS++C GF+
Sbjct: 1331 LGAYWRRVEC----STQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKI 1386
Query: 916 RSLKCVGHGGRLLARDQCNL 935
R ++CV +RD NL
Sbjct: 1387 REIQCVD------SRDHRNL 1400
Score = 69.7 bits (169), Expect = 1e-11
Identities = 36/102 (35%), Positives = 50/102 (49%), Gaps = 11/102 (10%)
Query: 832 VEQPDD------RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA--CD--AA 881
+++PD RP A W G+W CS +C G + R + C S R + C A
Sbjct: 1351 IQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAG 1410
Query: 882 HRPVETQACG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVG 922
P + +C EPC W++ WS CS+SCG G Q R + C G
Sbjct: 1411 IPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPG 1452
Score = 49.7 bits (117), Expect = 1e-05
Identities = 23/54 (42%), Positives = 27/54 (50%), Gaps = 4/54 (7%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVP----ACDAAHRPVETQACGE 892
W G+W CS SCG G QKR V C S G +T CD RP E + C +
Sbjct: 1475 WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQ 1528
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 5/58 (8%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPT 896
P+ W G+W CS SCG G++ R+V C + + CD +P CG + CP+
Sbjct: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDE----PCDVTRKPNSRALCGLQQCPS 998
Score = 32.7 bits (73), Expect = 1.7
Identities = 33/112 (29%), Positives = 44/112 (39%), Gaps = 30/112 (26%)
Query: 486 PWAD-GTSCG-----EGKLCLKGAC------VERHNLNKHRVDGSWA--KWDPYGPCSRT 531
PW+ SCG G C G C + N+H + WA WD CS +
Sbjct: 1431 PWSQCSRSCGGGVQERGVFCPGGLCDWTKRPTSTMSCNEH-LCCHWATGNWDL---CSTS 1486
Query: 532 CGGGVQLARRQCTNPTPANGGK-------YCEGV--RVKYRSCNLEPCPSSA 574
CGGG Q QC P+ G K C+ +++ CN + C SA
Sbjct: 1487 CGGGFQKRTVQC---VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKKSA 1535
Score = 30.8 bits (68), Expect = 6.3
Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 12/59 (20%)
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV--KYRSCNLEPCPSS 573
G+W++ CS +CGGGV++ C N + C+ R C L+ CPSS
Sbjct: 951 GNWSE------CSVSCGGGVRIRSVTCAK----NHDEPCDVTRKPNSRALCGLQQCPSS 999
Score = 30.4 bits (67), Expect = 8.2
Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 9/56 (16%)
Query: 523 DPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR--VKYRSCNLEPCPSSASG 576
+P+ CSR+CGGGVQ C G C+ + SCN C A+G
Sbjct: 1430 EPWSQCSRSCGGGVQERGVFCP-------GGLCDWTKRPTSTMSCNEHLCCHWATG 1478
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 444 bits (1142), Expect = e-124
Identities = 325/990 (32%), Positives = 448/990 (45%), Gaps = 127/990 (12%)
Query: 51 QGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAE 110
+ L ++ + DF++ L + +AP F + LG CFY G + +
Sbjct: 95 ESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFYQGSLRSH 154
Query: 111 PDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGA---HLLQRRGV----P 163
+S A+S C GL G A+Y + PLP+ + R +QG+ H+L +R P
Sbjct: 155 RNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAP 214
Query: 164 GGPSGDPTSR------------------------CGVASGWNPA-----ILRALDPYKPR 194
G TSR CG + P + D YK
Sbjct: 215 GASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYK-- 272
Query: 195 RAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLATAARLY 253
+ RS RS R + VETLVV D+ M++ HG + + Y+LT+L + L+
Sbjct: 273 -SCLRHKRSLLRSHRNEEL-----NVETLVVVDKKMMQNHGHENITTYVLTILNMVSALF 326
Query: 254 RHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKL-NKVSDKHPEYWDT 312
+ +I INI +V ++LL D G ++ +A TL +FC WQ L K +H D
Sbjct: 327 KDGTIGGNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRH----DH 382
Query: 313 AILFTRQDLCGATT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMP 370
AIL T D+C CDTLG A + MC RSC++ ED GL AFT AHE GH F M
Sbjct: 383 AILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMI 442
Query: 371 HDNV-KVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPS- 428
HD +C++ G + MSPTL + WS CS + FL + CL DQP
Sbjct: 443 HDGEGNMCKKSEGNI-----MSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKP 497
Query: 429 -KPISLPEDLPGASYTLSQQCELAFGVGSKPCPY---MQYCTKLWCTGKAKGQMVCQTRH 484
K PE LPG Y + QC+ FG +K C C LWC + C+T+
Sbjct: 498 VKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIGRK---CETKF 554
Query: 485 FPWADGTSCGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCT 544
P A+GT CG C G CV+ + G W+ W + PCSRTCGGGV R CT
Sbjct: 555 MPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCT 614
Query: 545 NPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWV 604
NP P++GGK+CEG + CN + CP + FR QC N W
Sbjct: 615 NPKPSHGGKFCEGSTRTLKLCNSQKCPRDS--VDFRAAQCAEHNSRRFRGRH----YKWK 668
Query: 605 PKYSGVSPRDKCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLG 664
P Y+ V +D CKL C A G +F+ L+ KV DGT CS DS +VC+ G C + GCD LG
Sbjct: 669 P-YTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLG 727
Query: 665 SKKRFDKCGVCGGDNKSCKKVTGLFTKPMH--GYNFVVAIPAGASSIDIRQRGYKGLIGD 722
S D CGVC G+N +C GL+TK H Y +V IP+GA SI I +
Sbjct: 728 SDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNV-----S 782
Query: 723 DNYLALKNSQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVE 782
+Y++++N+ +Y LNGH+ V R G+ Y + E+L A+ P E L VE
Sbjct: 783 TSYISVRNALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIVE 841
Query: 783 VLSVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLS------------- 829
+L G+ P V + + +P+ E + P P + S S+S
Sbjct: 842 LLFQGR--NPGVAWEYSMPRLGTEKQP--PAQPSYTWAIVRSECSVSCGGGQMTVREGCY 897
Query: 830 ----NQVE----QPDDRP------------PARWVAGSWGPCSASCGSGLQKRAVDC--R 867
QV P RP P W G+W CS +CG G Q R V C R
Sbjct: 898 RDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRR 957
Query: 868 GSAGQRTVPACDAAH-RPVETQAC-GEPC-PTWELSAWSPCSKSCGRGFQRRSLKCVGHG 924
VPA P QAC + C P W W+ CS +CG+G+++R++ C
Sbjct: 958 VHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTN 1017
Query: 925 ----GRLLARDQCNLHRKPQELDFCVLRPC 950
+LL C KP+ + C+L+ C
Sbjct: 1018 PSARAQLLPDAVCTSEPKPRMHEACLLQRC 1047
Score = 63.9 bits (154), Expect = 7e-10
Identities = 42/130 (32%), Positives = 58/130 (44%), Gaps = 24/130 (18%)
Query: 842 RWVAGSWGPCSASCGSGLQKRAVDCRG---SAGQRTVPACDAAHRPVET----QACGE-P 893
+W+ +W CS +C G QKR + C S R + + +H P + +AC P
Sbjct: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
Query: 894 CP-------------TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQ 940
CP +W S WS C+ SCG G Q RS++C+ GGR C LH+KP
Sbjct: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLA-GGR--PASGCLLHQKPS 1170
Query: 941 ELDFCVLRPC 950
C C
Sbjct: 1171 ASLACNTHFC 1180
Score = 34.3 bits (77), Expect = 0.57
Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 11/68 (16%)
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYR-----SCNLEPCP 571
GSW P+ C+ +CGGGVQ QC GG+ G + + +CN CP
Sbjct: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHFCP 1181
Query: 572 SSASGKSF 579
+ +F
Sbjct: 1182 IAEKKDAF 1189
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 439 bits (1129), Expect = e-123
Identities = 310/901 (34%), Positives = 431/901 (47%), Gaps = 80/901 (8%)
Query: 44 GPEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFY 103
G E+ L + +T F D +L L P+A+ +AP + E G +G T L C Y
Sbjct: 100 GNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE--KGTTRVEPLLGSCLY 157
Query: 104 SGDVNAEPD-SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQG-AHLLQRRG 161
GDV + S A+S C GL G E+ I PL A AQ QG H++ RR
Sbjct: 158 VGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLA--AQEAEQGRVHVVYRRP 215
Query: 162 VPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRY-V 220
P G P + AS L +LD R G E + RA+R + Y +
Sbjct: 216 PTSPPLGGPQALDTGAS------LDSLDSLS-RALGVLEEHANSSRRRARRHAADDDYNI 268
Query: 221 ETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGP 279
E L+ D+S+V+FHG + ++ YLLTL+ +Y S+ IN+V+V+++LL S
Sbjct: 269 EVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS 328
Query: 280 KVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTM 338
+ GN + +L N C W K H EY D AI TRQD + G A V M
Sbjct: 329 LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYAPVTGM 385
Query: 339 CDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQID 398
C P RSC++ +DG SAF AHE GHV M HD ++R +M+P +
Sbjct: 386 CHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDEVRLGSIMAPLVQAAF 443
Query: 399 RANPWSACSAAIITDFLDSGHGDCLLDQPSKPI--SLPEDLPGASYTLSQQCELAFGVGS 456
WS CS ++ +L S DCLLD P +LP+ LPG Y++++QC FG+G
Sbjct: 444 HRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQ-LPGLHYSMNEQCRFDFGLGY 500
Query: 457 KPCPYMQY---CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKH 513
C + C +LWC+ C+T+ P DGT C GK C KG C+
Sbjct: 501 MMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILK 559
Query: 514 RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSS 573
R DGSW W P+G CSRTCG GV+ RQC NP PANGG+ C G+ ++ C+ + CP S
Sbjct: 560 R-DGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDS 618
Query: 574 ASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAP 633
+ FREEQC ++ Y + W+P + +++C L C + TG +
Sbjct: 619 LA--DFREEQCRQWDLYFEHGD---AQHHWLP-HEHRDAKERCHLYCESRETGEVVSMKR 672
Query: 634 KVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK- 691
V DGT CS D+ S+CV+G C K GCDG +GS K+ DKCGVCGGDN CK V G FT+
Sbjct: 673 MVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRS 732
Query: 692 -PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQ-GKYLLNGHFVVSAVERD 749
HGY + IPAGA + I++ + ++LA+KN + GK++LN V A +
Sbjct: 733 PKKHGYIKMFEIPAGARHLLIQE-----VDATSHHLAVKNLETGKFILNEENDVDASSKT 787
Query: 750 LVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKS 809
+ G Y E+LQ P+ +TV V+ VG T + Y +
Sbjct: 788 FIAMGVEWEYRDE-DGRETLQTMGPLHGTITVLVIPVGD-TRVSLTYKY----------- 834
Query: 810 SHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGS 869
++H L++ + +D W W PCS CG G Q CR
Sbjct: 835 ----------MIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRR 884
Query: 870 AGQRTVPA--CDAAHRP------VETQACGEPCPTWELSAWSPCSKSCGR-GFQRRSLKC 920
+ V C A +P Q C + P W W PCS++CGR G Q RS++C
Sbjct: 885 LDHKMVHRGFCAALSKPKAIRRACNPQECSQ--PVWVTGEWEPCSQTCGRTGMQVRSVRC 942
Query: 921 V 921
+
Sbjct: 943 I 943
Score = 43.9 bits (102), Expect = 7e-04
Identities = 23/57 (40%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCP 895
P RW AG W CS +CG+G Q+R V CR + C RP + C PCP
Sbjct: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCR--TADDSFGICQ-EERPETARTCRLGPCP 1029
Score = 35.4 bits (80), Expect = 0.25
Identities = 36/129 (27%), Positives = 52/129 (40%), Gaps = 16/129 (12%)
Query: 463 QYCTK-LWCTGKAK------GQMVCQTRHF----PWADGTSCG-EGKLCLKGACVERHNL 510
Q C++ +W TG+ + G+ Q R P D T+ K C R
Sbjct: 911 QECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRAC 970
Query: 511 NKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVK-YRSCNLEP 569
++ G W + P+ CS TCG G Q C + G C+ R + R+C L P
Sbjct: 971 SRELCPGRW-RAGPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETARTCRLGP 1027
Query: 570 CPSSASGKS 578
CP + S S
Sbjct: 1028 CPRNISDPS 1036
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 424 bits (1090), Expect = e-118
Identities = 326/1026 (31%), Positives = 463/1026 (45%), Gaps = 176/1026 (17%)
Query: 13 GRTAGGSEPEREVVVPIRLDPDI-----------NGRRYYWRGPEDS-----GDQGLIFQ 56
G G + + EVV+P R+ PD RR R P + G++ L+
Sbjct: 25 GTAVGDAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPPAAPRARPGERALLLH 84
Query: 57 ITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFYSGDVNAEPDSFAA 116
+ AF D YL L D +FL+ F E G + G ++L CFYSG V P S +
Sbjct: 85 LPAFGRDLYLQLRRDLRFLSRGFEVEEAGAARR--RGRPAEL--CFYSGRVLGHPGSLVS 140
Query: 117 VSLCGGLRGAFGY--RGAEYV-ISPLPNASAPAAQRNSQGAHLLQRR-GVPGGPSGD--- 169
+S CG G G G E V I PL N+ P + R HL++R+ + PS +
Sbjct: 141 LSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGRE----HLIRRKWSLTPSPSAEAQR 196
Query: 170 PTSRCGVASGWNPAILRALDPYKPRRAGFGE-SRSRRRSGRAKRFVSIPRYVETLVVADE 228
P C V + + ++ +G SR R A R S VETLVVAD
Sbjct: 197 PEQLCKVLT-------------EKKKPTWGRPSRDWRERRNAIRLTS-EHTVETLVVADA 242
Query: 229 SMVKFHGADL-EHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAAL 287
MV++HGA+ + ++LT++ +++H S+ INI V K++LLR R + + +
Sbjct: 243 DMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGER 302
Query: 288 TLRNFCAWQKKL---------NKV--SDKHPEYWDTAILFTRQDLC--GATTCDTLGMAD 334
+L +FC WQ + N+V P D A+ TR D C CDT+G+A
Sbjct: 303 SLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAY 362
Query: 335 VGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTL 394
+G +C KR C + ED+GL AFT AHELGH M HD ++ +H+MS
Sbjct: 363 LGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHD-----DDHSSCAGRSHIMSGEW 417
Query: 395 IQIDRANP----WSACSAAIITDFLDSGHGDCLL---DQPSKPISLPEDLPGASYTLSQQ 447
++ NP WS+CS + +FL S CLL + + LP LPG Y+ ++Q
Sbjct: 418 VK--GRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQ 475
Query: 448 CELAFGVGSKPCPYMQY--CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACV 505
C++ FG+ + C M++ C LWC +G C+T+ P DGT CG K C G CV
Sbjct: 476 CQILFGMNATFCRNMEHLMCAGLWCL--VEGDTSCKTKLDPPLDGTECGADKWCRAGECV 533
Query: 506 ERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSC 565
+ + +H VDG W+ W + CSRTCG G + +R+C NP P GG +C G V++ C
Sbjct: 534 SKTPIPEH-VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVC 592
Query: 566 NLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGT 625
PCP SFR++QC+A + + L AV K C+L C G
Sbjct: 593 ENLPCPKGLP--SFRDQQCQAHDRLSPKKKGLLTAVVVDDK--------PCELYCSPLGK 642
Query: 626 GYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKV 685
++A +V+DGT C P T +CV GKC K GCDG +GS + D+CGVC GD K+C V
Sbjct: 643 ESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLV 702
Query: 686 TGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSA 745
G F+ A ++ G KG I NS K L G F ++
Sbjct: 703 KGDFSH--------------ARGTALKDSG-KGSI---------NSDWKIELPGEFQIA- 737
Query: 746 VERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPR 805
G+ +RY G E + A P PL + VL + Y + +P
Sbjct: 738 --------GTTVRYVRRG-LWEKISAKGPTKLPLHLMVLLFHDQ-DYGIHYEYTVPVNRT 787
Query: 806 EDKSSHPKDPR------------GPSV---------------LHNSVLSLSNQVEQPDDR 838
+ S P+ P+ G SV + N +L N + P
Sbjct: 788 AENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQAS 847
Query: 839 PP-------------ARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPACDAA 881
P +RWVAG W PCSA+C G Q R V C + T P
Sbjct: 848 RPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG 907
Query: 882 HRPVETQAC-GEPC-PTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKP 939
RP Q+C G+ C WE S WS CS SCG+G +R++ C G+ C+ +P
Sbjct: 908 PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK------CDASTRP 961
Query: 940 QELDFC 945
+ + C
Sbjct: 962 RAEEAC 967
Score = 77.0 bits (188), Expect = 8e-14
Identities = 41/110 (37%), Positives = 53/110 (48%), Gaps = 8/110 (7%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE--PCPTWELS 900
W A W CSASCG G+ KR V C S G+ CDA+ RP +AC + C W+
Sbjct: 925 WEASEWSQCSASCGKGVWKRTVACTNSQGK-----CDASTRPRAEEACEDYSGCYEWKTG 979
Query: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
WS CS +CG+G Q R ++C+ H +C KP C C
Sbjct: 980 DWSTCSSTCGKGLQSRVVQCM-HKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 34.7 bits (78), Expect = 0.43
Identities = 41/175 (23%), Positives = 57/175 (32%), Gaps = 17/175 (9%)
Query: 400 ANPWSACSAAIITDFLDSGHGDCL--LDQPSKPISLPEDLPGASYTLSQQCELAFGVGSK 457
A PWS CSA F C+ L + + P PG Q CE +
Sbjct: 867 AGPWSPCSATCEKGF-QHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIW 925
Query: 458 PCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVDG 517
C+ G K + C + G + + AC + + + G
Sbjct: 926 EASEWSQCSASCGKGVWKRTVACTN-----SQGKCDASTRPRAEEACEDYSGCYEWKT-G 979
Query: 518 SWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR--VKYRSCNLEPC 570
W+ CS TCG G+Q QC + G C + YR C E C
Sbjct: 980 DWST------CSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 413 bits (1061), Expect = e-115
Identities = 294/924 (31%), Positives = 423/924 (45%), Gaps = 114/924 (12%)
Query: 48 SGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTE---------HLGVPLQGLTGGSSDL 98
S + L F ITAF +DF+L L P+ Q +AP E ++ P+ GS+
Sbjct: 75 SNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATY 134
Query: 99 R---------RCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQR 149
R C Y GD+ P + A+S C GL G EY I PL ++
Sbjct: 135 RIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEK 194
Query: 150 NSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDP----YKPRRAGFGESRSRR 205
H++ +R D + + + L LD Y E+ RR
Sbjct: 195 GR--IHVVYKRSAVEQAPIDMSKDFH----YRESDLEGLDDLGTVYGNIHQQLNETMRRR 248
Query: 206 RSGRAKRFVSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINI 264
R + +E L+ D+S+V+FHG + +++YLLTL+ +Y S+ IN+
Sbjct: 249 RHAGENDY-----NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINV 303
Query: 265 VVVKVLLLRDRDSGPKVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCG 323
V+V++++L S + GN + +L N C W + + H E+ D AI TRQD
Sbjct: 304 VLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGP 363
Query: 324 ATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGK 383
A G A V MC P RSC++ +DG SAF AHE GHV M HD +
Sbjct: 364 A---GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDE 418
Query: 384 LRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI--SLPEDLPGAS 441
+M+P + WS CS + ++ S DCLLD P LPE LPG +
Sbjct: 419 TAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLPE-LPGIN 475
Query: 442 YTLSQQCELAFGVGSKPCPYMQY---CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKL 498
Y++ +QC FGVG K C + C +LWC+ C+T+ P DGT C GK
Sbjct: 476 YSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTECAAGKW 534
Query: 499 CLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGV 558
C KG C+ + N N+ + DG+W W +G CSRTCG GV+ RQC NP P NGG+ C GV
Sbjct: 535 CYKGHCMWK-NANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGV 593
Query: 559 RVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKL 618
+Y+ CN E C + FR +QC+ N + N W+P Y P+ +C L
Sbjct: 594 NFEYQLCNTEECQKHF--EDFRAQQCQQRNSHFEYQN---TKHHWLP-YEHPDPKKRCHL 647
Query: 619 ICRANGTGYFYVLAPKVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGG 677
C++ TG + V DGT CS D S+CV+G+C+K GCD +GS K DKCGVCGG
Sbjct: 648 YCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGG 707
Query: 678 DNKSCKKVTGLFTKPMH--GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKN-SQGK 734
DN C+ V G FT+ GY + IP GA + I++ + LA+KN + G
Sbjct: 708 DNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDE-----ASPHILAIKNQATGH 762
Query: 735 YLLNGH--------FVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSV 786
Y+LNG F+ VE D ++ +ESL P+ +P+ V ++
Sbjct: 763 YILNGKGEEAKSRTFIDLGVEWDYNIEDD----------IESLHTDGPLHDPVIVLIIPQ 812
Query: 787 GKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAG 846
T + Y + + ED P++ N+V+ ++ W
Sbjct: 813 ENDTRSSLTYKYII----HEDSV--------PTINSNNVIQ--------EELDTFEWALK 852
Query: 847 SWGPCSASCGSGLQKRAVDCRGSAGQRTV--PACDAAHRP------VETQACGEPCPTWE 898
SW CS CG G Q CR + + V C+A +P Q C P W
Sbjct: 853 SWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTH--PLWV 910
Query: 899 LSAWSPCSKSCG-RGFQRRSLKCV 921
W C+K+CG G+Q R+++C+
Sbjct: 911 AEEWEHCTKTCGSSGYQLRTVRCL 934
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/61 (39%), Positives = 29/61 (47%), Gaps = 13/61 (21%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC------GEP 893
PA+W G W CS +CG G + R V CR AG CD +P +AC EP
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCR--AGDH----CD-GEKPESVRACQLPPCNDEP 1019
Query: 894 C 894
C
Sbjct: 1020 C 1020
Score = 41.2 bits (95), Expect = 0.005
Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 13/111 (11%)
Query: 463 QYCTKLWCTGKAKGQMVCQTRHF-PWADGTSCG-EGKLCLKGACVERHNLNKHRVDGSWA 520
++CTK T + G + R P DGT+ K C+ R N+ W
Sbjct: 915 EHCTK---TCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQW- 970
Query: 521 KWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVK-YRSCNLEPC 570
K P+ CS TCG G ++ + C G +C+G + + R+C L PC
Sbjct: 971 KTGPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESVRACQLPPC 1015
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 403 bits (1035), Expect = e-112
Identities = 306/950 (32%), Positives = 438/950 (46%), Gaps = 117/950 (12%)
Query: 46 EDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRR----- 100
E GD+ L+ +I AF D YL L D +FLAP F+ E P G TG +S +
Sbjct: 159 EPDGDEVLL-RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPD 217
Query: 101 --CFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYV-ISPLPNASAPAAQRNSQGAHLL 157
CFY+G V P S A+ S CGG F +++ I PL + A +
Sbjct: 218 AGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMAITGHPHRVYRQKR 277
Query: 158 QRRGVPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRF-VSI 216
S + CG+ S D +PR SR SGR KR+ +
Sbjct: 278 SMEEKVTEKSALHSHYCGIIS----------DKGRPR------SRKIAESGRGKRYSYKL 321
Query: 217 PRY--VETLVVADESMVKFHGADL-EHYLLTLLATAARLYRHPSILNPINIVVVKVLLLR 273
P+ +ET+VVAD +MV +HGAD ++LT+L L++H S+ +N+ V+K++LL
Sbjct: 322 PQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLH 381
Query: 274 DRDSGPKVTGNAALTLRNFCAWQ-KKLNKVSDKHPEY---W-------DTAILFTRQDLC 322
+ + + L +FC WQ ++ K +D H E W D AIL TR+D C
Sbjct: 382 ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFC 441
Query: 323 --GATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKV-CEE 379
CDT+G+A + MC KR C + ED+GL AFT AHE+GH + HDN C +
Sbjct: 442 VHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD 501
Query: 380 VFGKLRANHMMSPTLIQIDRANP--WSACSAAIITDFLDSGHGDCLLD---QPSKPISLP 434
H+MS I+ WS CS + FL S +CLL Q + +P
Sbjct: 502 GL------HIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVP 555
Query: 435 EDLPGASYTLSQQCELAFGVGSKPCPYMQY--CTKLWCTGKAKGQMVCQTRHFPWADGTS 492
LPG +YT +QC++ FG + C MQ+ CT LWC K +G+ C+T+ P DGT
Sbjct: 556 SKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWC--KVEGEKECRTKLDPPMDGTD 613
Query: 493 CGEGKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGG 552
C GK C G C R + +H + G W+ W P CSRTC G+ R+C P +
Sbjct: 614 CDLGKWCKAGECTSRTSAPEH-LAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEA 667
Query: 553 KYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSP 612
+ C G R +YR C PCP+ G FR+ QC+A++ S + ++ V
Sbjct: 668 RDCNGPRKQYRICENPPCPAGLPG--FRDWQCQAYSVRTSSPKHIL-------QWQAVLD 718
Query: 613 RDK-CKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDK 671
+K C L C G +L+ KV+DGT C +C G+C K GCDG LGS R D
Sbjct: 719 EEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDH 778
Query: 672 CGVCGGDNKSCKKVTGLFTKPMH-GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKN 730
CGVC G+ KSCK + G F GY V+ IPAGA I + + +YLAL++
Sbjct: 779 CGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPA-----HSYLALRD 833
Query: 731 SQGKYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMT 790
+ GK +N + + + G+ + Y G E + A P PL + VL
Sbjct: 834 A-GKQSINSDWKIEH-SGAFNLAGTTVHYVRRGLW-EKISAKGPTTAPLHLLVLLFQDQN 890
Query: 791 PPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGP 850
+ Y + +P +P + S K P P W SW
Sbjct: 891 YG-LHYEYTIPSDPLPENQSS-KAPE----------------------PLFMWTHTSWED 926
Query: 851 CSASCGSGLQKRAVDCRGSAGQRTV----PACDAAHRPV-ETQACGE-PCPT-WELSAWS 903
C A+CG G +K V C + C +P + + C E PC T W ++ W+
Sbjct: 927 CDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWT 986
Query: 904 PCSKSCGRGFQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
PCS++CG+G Q R + C + +G + AR++ + KP C + C
Sbjct: 987 PCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDC 1036
Score = 70.9 bits (172), Expect = 5e-12
Identities = 37/110 (33%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE--PCPTWELS 900
W AG W CS CG G++ R V C + C + RP E + C + C W +
Sbjct: 1040 WEAGVWSECSVKCGKGIRHRTVRCTNPRKK-----CVLSTRPREAEDCEDYSKCYVWRMG 1094
Query: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
WS CS +CG+G Q R ++C+ H ++C KP C L+PC
Sbjct: 1095 DWSKCSITCGKGMQSRVIQCM-HKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/55 (36%), Positives = 24/55 (43%), Gaps = 5/55 (9%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPAC-----DAAHRPVETQACGE 892
W G W CS +CG G+Q R + C R C AA+RP Q C E
Sbjct: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE 1145
Score = 36.6 bits (83), Expect = 0.11
Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 8/56 (14%)
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR--VKYRSCNLEPC 570
G W+K CS TCG G+Q QC + G C YR C+L+PC
Sbjct: 1094 GDWSK------CSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 398 bits (1022), Expect = e-110
Identities = 292/941 (31%), Positives = 422/941 (44%), Gaps = 105/941 (11%)
Query: 45 PEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEH-------LGVPLQGLTGGSSD 97
P G L F +T F ++ +L L P+ + + P S E PL+
Sbjct: 98 PGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLR-------- 149
Query: 98 LRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLL 157
+ C Y+G V P + A+S C GL G ++ I PL + S H++
Sbjct: 150 -QECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQE--KEASGRTHVV 206
Query: 158 QRRGVP----GGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRF 213
RR P GD + G P +L + G++ +RR + +
Sbjct: 207 YRREAVQQEWAEPDGDLHNEA-FGLGDLPNLLGLVGDQ------LGDTERKRRHAKPGSY 259
Query: 214 VSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINIVVVKVLLL 272
+E L+V D+S+V+FHG + +++Y+LTL+ +Y S+ INI +V+++++
Sbjct: 260 S-----IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMV 314
Query: 273 RDRDSGPKVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLG 331
R S + GN + +L C W + H E+ D + TRQD + G
Sbjct: 315 GYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS------G 368
Query: 332 MADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNV-KVCEEVFGKLRANHMM 390
A V MC P RSC++ +DG SAF AHE GHV M HD C + + +M
Sbjct: 369 YAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD---ETSLGSVM 425
Query: 391 SPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI-SLPEDLPGASYTLSQQCE 449
+P + WS CS ++ +L S DCLLD P P P +LPG +Y++ +QC
Sbjct: 426 APLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCR 483
Query: 450 LAFGVGSKPC---PYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVE 506
FG G + C + C +LWC+ C+T+ P DGT C GK C KG C+
Sbjct: 484 FDFGSGYQTCLAFRTFEPCKQLWCS-HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW 542
Query: 507 RHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCN 566
+ + DG W+ W +G CSR+CGGGV+ R C NP+PA GG+ C G +Y+ CN
Sbjct: 543 KSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCN 602
Query: 567 LEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTG 626
E CP + + FR +QC N Y N +WVP Y KC+LIC++ TG
Sbjct: 603 SEECPGTY--EDFRAQQCAKRNSYYVHQN---AKHSWVP-YEPDDDAQKCELICQSADTG 656
Query: 627 YFYVLAPKVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKV 685
+ V DGT CS D SVC +G+C+ GCD +GS K DKCGVCGGDN C+ V
Sbjct: 657 DVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTV 716
Query: 686 TGLFTK--PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNS-QGKYLLNGHFV 742
G K G +V IPAGA I I + L + + +KN G ++LN
Sbjct: 717 KGTLGKASKQAGALKLVQIPAGARHIQI-----EALEKSPHRIVVKNQVTGSFILNPK-G 770
Query: 743 VSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTP-PRVRYSFYLP 801
A R G L A ESL+ S P+ E + + L + P + Y +
Sbjct: 771 KEATSRTFTAMG-LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKY--- 826
Query: 802 KEPREDKSSHPKDPRGPSVLHNSVLSL--SNQVEQPDDRPPARWVAGSWGPCSASCGSGL 859
V+H +L L SN V ++ W SW PCS +CG G+
Sbjct: 827 ------------------VIHEDLLPLIGSNNV-LLEEMDTYEWALKSWAPCSKACGGGI 867
Query: 860 QKRAVDCRGSAGQRTVP--ACDAAHR--PVETQACGEPC--PTWELSAWSPCSKSCGR-G 912
Q CR V CD R P+ + PC P W W CS+SCG+ G
Sbjct: 868 QFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLG 927
Query: 913 FQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Q R ++C + +G + + +P+ C+ PC
Sbjct: 928 VQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 968
Score = 67.8 bits (164), Expect = 5e-11
Identities = 43/116 (37%), Positives = 52/116 (44%), Gaps = 13/116 (11%)
Query: 843 WVAGSWGPCSASCGS-GLQKRAVDC-----RGSAGQRTVPACDAAHRPVETQACGE-PCP 895
WV WG CS SCG G+Q R + C G+ AC A RP + C PCP
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCP 969
Query: 896 T-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W L AWS CS +CG G Q+R + C + L C R P + C L C
Sbjct: 970 AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEGDR-PDTVQVCSLPAC 1021
Score = 48.5 bits (114), Expect = 3e-05
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP 893
PA+W G+W CSA+CG G+Q+R V CR +A ++ C+ RP Q C P
Sbjct: 969 PAQWRLGAWSQCSATCGEGIQQRQVVCRTNA--NSLGHCE-GDRPDTVQVCSLP 1019
Score = 38.1 bits (87), Expect = 0.039
Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 42/176 (23%)
Query: 458 PCPYMQYCTKLW-CTGKAKGQMVCQTRHF----PWADGT-------SCGEGKL-----CL 500
PC + T+ W ++ G++ QTR P ++GT +C + CL
Sbjct: 905 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 964
Query: 501 KGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV 560
+ C + L G+W++ CS TCG G+Q +RQ T AN +CEG R
Sbjct: 965 RVPCPAQWRL------GAWSQ------CSATCGEGIQ--QRQVVCRTNANSLGHCEGDRP 1010
Query: 561 -KYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDK 615
+ C+L C + + R + E T WVP+ + P +K
Sbjct: 1011 DTVQVCSLPACGGNHQNSTVRADVWELG----------TPEGQWVPQSEPLHPINK 1056
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1
motif, 14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 397 bits (1021), Expect = e-110
Identities = 292/941 (31%), Positives = 422/941 (44%), Gaps = 102/941 (10%)
Query: 45 PEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEH-------LGVPLQGLTGGSSD 97
P G L F +T F ++ +L L P+ + + P S E PL+
Sbjct: 98 PGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQEDFRELFRQPLR-------- 149
Query: 98 LRRCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLL 157
+ C Y+G V P + A+S C GL G ++ I PL + S H++
Sbjct: 150 -QECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQE--KEASGRTHVV 206
Query: 158 QRRGVP----GGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRF 213
RR P GD + G P +L + G++ +RR + +
Sbjct: 207 YRREAVQQEWAEPDGDLHNEA-FGLGDLPNLLGLVGDQ------LGDTERKRRHAKPGSY 259
Query: 214 VSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINIVVVKVLLL 272
+E L+V D+S+V+FHG + +++Y+LTL+ +Y S+ INI +V+++++
Sbjct: 260 S-----IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMV 314
Query: 273 RDRDSGPKVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLG 331
R S + GN + +L C W + H E+ D + TRQD + G
Sbjct: 315 GYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS---GMQG 371
Query: 332 MADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNV-KVCEEVFGKLRANHMM 390
A V MC P RSC++ +DG SAF AHE GHV M HD C + + +M
Sbjct: 372 YAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCAD---ETSLGSVM 428
Query: 391 SPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI-SLPEDLPGASYTLSQQCE 449
+P + WS CS ++ +L S DCLLD P P P +LPG +Y++ +QC
Sbjct: 429 APLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCR 486
Query: 450 LAFGVGSKPC---PYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVE 506
FG G + C + C +LWC+ C+T+ P DGT C GK C KG C+
Sbjct: 487 FDFGSGYQTCLAFRTFEPCKQLWCS-HPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW 545
Query: 507 RHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCN 566
+ + DG W+ W +G CSR+CGGGV+ R C NP+PA GG+ C G +Y+ CN
Sbjct: 546 KSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCN 605
Query: 567 LEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTG 626
E CP + + FR +QC N Y N +WVP Y KC+LIC++ TG
Sbjct: 606 SEECPGTY--EDFRAQQCAKRNSYYVHQN---AKHSWVP-YEPDDDAQKCELICQSADTG 659
Query: 627 YFYVLAPKVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKV 685
+ V DGT CS D SVC +G+C+ GCD +GS K DKCGVCGGDN C+ V
Sbjct: 660 DVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTV 719
Query: 686 TGLFTK--PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNS-QGKYLLNGHFV 742
G K G +V IPAGA I I + L + + +KN G ++LN
Sbjct: 720 KGTLGKASKQAGALKLVQIPAGARHIQI-----EALEKSPHRIVVKNQVTGSFILNPK-G 773
Query: 743 VSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTP-PRVRYSFYLP 801
A R G L A ESL+ S P+ E + + L + P + Y +
Sbjct: 774 KEATSRTFTAMG-LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKY--- 829
Query: 802 KEPREDKSSHPKDPRGPSVLHNSVLSL--SNQVEQPDDRPPARWVAGSWGPCSASCGSGL 859
V+H +L L SN V ++ W SW PCS +CG G+
Sbjct: 830 ------------------VIHEDLLPLIGSNNV-LLEEMDTYEWALKSWAPCSKACGGGI 870
Query: 860 QKRAVDCRGSAGQRTVP--ACDAAHR--PVETQACGEPC--PTWELSAWSPCSKSCGR-G 912
Q CR V CD R P+ + PC P W W CS+SCG+ G
Sbjct: 871 QFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLG 930
Query: 913 FQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Q R ++C + +G + + +P+ C+ PC
Sbjct: 931 VQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 971
Score = 67.8 bits (164), Expect = 5e-11
Identities = 43/116 (37%), Positives = 52/116 (44%), Gaps = 13/116 (11%)
Query: 843 WVAGSWGPCSASCGS-GLQKRAVDC-----RGSAGQRTVPACDAAHRPVETQACGE-PCP 895
WV WG CS SCG G+Q R + C G+ AC A RP + C PCP
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCP 972
Query: 896 T-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W L AWS CS +CG G Q+R + C + L C R P + C L C
Sbjct: 973 AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEGDR-PDTVQVCSLPAC 1024
Score = 48.5 bits (114), Expect = 3e-05
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP 893
PA+W G+W CSA+CG G+Q+R V CR +A ++ C+ RP Q C P
Sbjct: 972 PAQWRLGAWSQCSATCGEGIQQRQVVCRTNA--NSLGHCE-GDRPDTVQVCSLP 1022
Score = 38.1 bits (87), Expect = 0.039
Identities = 45/176 (25%), Positives = 71/176 (40%), Gaps = 42/176 (23%)
Query: 458 PCPYMQYCTKLW-CTGKAKGQMVCQTRHF----PWADGT-------SCGEGKL-----CL 500
PC + T+ W ++ G++ QTR P ++GT +C + CL
Sbjct: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
Query: 501 KGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV 560
+ C + L G+W++ CS TCG G+Q +RQ T AN +CEG R
Sbjct: 968 RVPCPAQWRL------GAWSQ------CSATCGEGIQ--QRQVVCRTNANSLGHCEGDRP 1013
Query: 561 -KYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDK 615
+ C+L C + + R + E T WVP+ + P +K
Sbjct: 1014 DTVQVCSLPACGGNHQNSTVRADVWELG----------TPEGQWVPQSEPLHPINK 1059
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 313 bits (801), Expect = 6e-85
Identities = 230/803 (28%), Positives = 338/803 (42%), Gaps = 95/803 (11%)
Query: 190 PYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATA 249
P K R G R R+R RA + ++E LV + + H D E Y+LT L
Sbjct: 55 PLKGRPPSPGFQRQRQRQRRAAGGIL---HLELLVAVGPDVFQAHQEDTERYVLTNLNIG 111
Query: 250 ARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEY 309
A L R PS+ + +VK+++L + + P +T N +L + C W + +N D P +
Sbjct: 112 AELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGH 171
Query: 310 WDTAILFTRQDL-CGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFN 368
D + TR DL G+ +G C P SC + ED G T AHE+GH F
Sbjct: 172 ADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFG 231
Query: 369 MPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLD--- 425
+ HD G + H+M+ WS CS + L +G C+ D
Sbjct: 232 LEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPR 287
Query: 426 -QPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPY----MQYCTKLWCTGKAKGQMVC 480
QP P+ PG Y+ ++QC +AFG + C + + C L C Q C
Sbjct: 288 PQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSC 347
Query: 481 QTRHFPWADGTSCGEGKLCLKGACVERHNLNK-HRVDGSWAKWDPYGPCSRTCGGGVQLA 539
P DGT CG K C KG C L V G W+ W P PCSR+CGGGV
Sbjct: 348 SRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTR 407
Query: 540 RRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTL 599
RRQC NP PA GG+ C G ++ CN + C + F +QC +G R +
Sbjct: 408 RRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQ--LEFMSQQCARTDG---QPLRSSP 462
Query: 600 AVAWVPKYSGVSPRDK----CKLICRANGTGYFYVLAPKVVDGTLCSPD------STSVC 649
A + P + C+ +CRA G + +DGT C P + S+C
Sbjct: 463 GGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLC 522
Query: 650 VQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSI 709
V G C GCDG + S++ +D+C VCGGDN +C G FT +V + +
Sbjct: 523 VSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAG-RAREYVTFLTVTPNLT 581
Query: 710 DIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVS------AVERDLVVKGSLLRYSGTG 763
+ ++ L +LA++ G+Y++ G +S ++ D V+ +
Sbjct: 582 SVYIANHRPLF---THLAVRIG-GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRL 637
Query: 764 TAVESLQASRPILEPLTVEVL-----SVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGP 818
+E ++ P+ E ++V G +T P + ++++ PK
Sbjct: 638 PRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPK---------------- 681
Query: 819 SVLHNSVLSLSNQVEQPDDRPPARWV-AGSWGPCSASCGSGLQKRAVDCRGSAGQ---RT 874
P WV A GPCS SCG+GL+ C A + T
Sbjct: 682 --------------------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVET 721
Query: 875 VPACDAAHRPVETQACG-EPCPT-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLL---- 928
V + P +AC EPCP W + + PCS SCG G + R ++CV G LL
Sbjct: 722 VQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP 781
Query: 929 -ARDQCNLHRKPQELDFCVLRPC 950
AR + + L+ C +PC
Sbjct: 782 PARCRAGAQQPAVALETCNPQPC 804
Score = 70.1 bits (170), Expect = 9e-12
Identities = 43/118 (36%), Positives = 54/118 (45%), Gaps = 7/118 (5%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPACDAAHRPVETQAC--GEP 893
P RW S GPCSASCG G +R+V C +G + AC A RP + C +
Sbjct: 1013 PPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Query: 894 CPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRL-LARDQCNLHRKPQELDFCVLRPC 950
W + W CS SCG G QRR C+G + + D C KP + C PC
Sbjct: 1073 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/111 (35%), Positives = 48/111 (43%), Gaps = 9/111 (8%)
Query: 849 GPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRP-VETQAC-GEPCPTWELSAWSP 904
G CS SCG GL + C SA + V C A +P + C PCP +
Sbjct: 902 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAA 961
Query: 905 CSKSCGRGFQRRSLKCV-----GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
CS SCGRG RR L C G +L QC +P+ + C L PC
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPC 1012
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/147 (23%), Positives = 47/147 (31%), Gaps = 36/147 (24%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPC----- 894
PARW C+++ G+GL C A P + E EPC
Sbjct: 805 PARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSC 864
Query: 895 -PTW------------------------ELSAWSP----CSKSCGRGFQRRSLKCVGHGG 925
P W W+P CS SCGRG C+
Sbjct: 865 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL 924
Query: 926 RLLARDQ-CNLHRKP-QELDFCVLRPC 950
R+ +++ C L KP + C PC
Sbjct: 925 RVPVQEELCGLASKPGSRREVCQAVPC 951
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 313 bits (801), Expect = 6e-85
Identities = 230/803 (28%), Positives = 338/803 (42%), Gaps = 95/803 (11%)
Query: 190 PYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATA 249
P K R G R R+R RA + ++E LV + + H D E Y+LT L
Sbjct: 55 PLKGRPPSPGFQRQRQRQRRAAGGIL---HLELLVAVGPDVFQAHQEDTERYVLTNLNIG 111
Query: 250 ARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEY 309
A L R PS+ + +VK+++L + + P +T N +L + C W + +N D P +
Sbjct: 112 AELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGH 171
Query: 310 WDTAILFTRQDL-CGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFN 368
D + TR DL G+ +G C P SC + ED G T AHE+GH F
Sbjct: 172 ADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFG 231
Query: 369 MPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLD--- 425
+ HD G + H+M+ WS CS + L +G C+ D
Sbjct: 232 LEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPR 287
Query: 426 -QPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPY----MQYCTKLWCTGKAKGQMVC 480
QP P+ PG Y+ ++QC +AFG + C + + C L C Q C
Sbjct: 288 PQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSC 347
Query: 481 QTRHFPWADGTSCGEGKLCLKGACVERHNLNK-HRVDGSWAKWDPYGPCSRTCGGGVQLA 539
P DGT CG K C KG C L V G W+ W P PCSR+CGGGV
Sbjct: 348 SRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTR 407
Query: 540 RRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTL 599
RRQC NP PA GG+ C G ++ CN + C + F +QC +G R +
Sbjct: 408 RRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQ--LEFMSQQCARTDG---QPLRSSP 462
Query: 600 AVAWVPKYSGVSPRDK----CKLICRANGTGYFYVLAPKVVDGTLCSPD------STSVC 649
A + P + C+ +CRA G + +DGT C P + S+C
Sbjct: 463 GGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLC 522
Query: 650 VQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSI 709
V G C GCDG + S++ +D+C VCGGDN +C G FT +V + +
Sbjct: 523 VSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAG-RAREYVTFLTVTPNLT 581
Query: 710 DIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVS------AVERDLVVKGSLLRYSGTG 763
+ ++ L +LA++ G+Y++ G +S ++ D V+ +
Sbjct: 582 SVYIANHRPLF---THLAVRIG-GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRL 637
Query: 764 TAVESLQASRPILEPLTVEVL-----SVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGP 818
+E ++ P+ E ++V G +T P + ++++ PK
Sbjct: 638 PRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPK---------------- 681
Query: 819 SVLHNSVLSLSNQVEQPDDRPPARWV-AGSWGPCSASCGSGLQKRAVDCRGSAGQ---RT 874
P WV A GPCS SCG+GL+ C A + T
Sbjct: 682 --------------------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVET 721
Query: 875 VPACDAAHRPVETQACG-EPCPT-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLL---- 928
V + P +AC EPCP W + + PCS SCG G + R ++CV G LL
Sbjct: 722 VQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP 781
Query: 929 -ARDQCNLHRKPQELDFCVLRPC 950
AR + + L+ C +PC
Sbjct: 782 PARCRAGAQQPAVALETCNPQPC 804
Score = 70.1 bits (170), Expect = 9e-12
Identities = 43/118 (36%), Positives = 54/118 (45%), Gaps = 7/118 (5%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPACDAAHRPVETQAC--GEP 893
P RW S GPCSASCG G +R+V C +G + AC A RP + C +
Sbjct: 1013 PPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Query: 894 CPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRL-LARDQCNLHRKPQELDFCVLRPC 950
W + W CS SCG G QRR C+G + + D C KP + C PC
Sbjct: 1073 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/111 (35%), Positives = 48/111 (43%), Gaps = 9/111 (8%)
Query: 849 GPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRP-VETQAC-GEPCPTWELSAWSP 904
G CS SCG GL + C SA + V C A +P + C PCP +
Sbjct: 902 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAA 961
Query: 905 CSKSCGRGFQRRSLKCV-----GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
CS SCGRG RR L C G +L QC +P+ + C L PC
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPC 1012
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/147 (23%), Positives = 47/147 (31%), Gaps = 36/147 (24%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPC----- 894
PARW C+++ G+GL C A P + E EPC
Sbjct: 805 PARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSC 864
Query: 895 -PTW------------------------ELSAWSP----CSKSCGRGFQRRSLKCVGHGG 925
P W W+P CS SCGRG C+
Sbjct: 865 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL 924
Query: 926 RLLARDQ-CNLHRKP-QELDFCVLRPC 950
R+ +++ C L KP + C PC
Sbjct: 925 RVPVQEELCGLASKPGSRREVCQAVPC 951
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 287 bits (735), Expect = 3e-77
Identities = 221/799 (27%), Positives = 326/799 (40%), Gaps = 118/799 (14%)
Query: 190 PYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATA 249
P K R G R R+R RA + ++E LV + + H D E Y+LT L
Sbjct: 55 PLKGRPPSPGFQRQRQRQRRAAGGIL---HLELLVAVGPDVFQAHQEDTERYVLTNLNIG 111
Query: 250 ARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEY 309
A L R PS+ + +VK+++L + + P +T N +L + C W + +N D P +
Sbjct: 112 AELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGH 171
Query: 310 WDTAILFTRQDL-CGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFN 368
D + TR DL G+ +G C P SC + ED G T AHE+GH F
Sbjct: 172 ADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFG 231
Query: 369 MPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPS 428
+ HD G + H+M+ WS CS + L +
Sbjct: 232 LEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA----------- 276
Query: 429 KPISLPEDLPGASYTLSQQCELAFGVGSKPCPY----MQYCTKLWCTGKAKGQMVCQTRH 484
++QC +AFG + C + + C L C Q C
Sbjct: 277 ----------------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLL 320
Query: 485 FPWADGTSCGEGKLCLKGACVERHNLNK-HRVDGSWAKWDPYGPCSRTCGGGVQLARRQC 543
P DGT CG K C KG C L V G W+ W P PCSR+CGGGV RRQC
Sbjct: 321 VPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQC 380
Query: 544 TNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAW 603
NP PA GG+ C G ++ CN + C + F +QC +G R + A
Sbjct: 381 NNPRPAFGGRACVGADLQAEMCNTQACEKTQ--LEFMSQQCARTDG---QPLRSSPGGAS 435
Query: 604 VPKYSGVSPRDK----CKLICRANGTGYFYVLAPKVVDGTLCSPD------STSVCVQGK 653
+ P + C+ +CRA G + +DGT C P + S+CV G
Sbjct: 436 FYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGS 495
Query: 654 CIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQ 713
C GCDG + S++ +D+C VCGGDN +C G FT +V + + +
Sbjct: 496 CRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAG-RAREYVTFLTVTPNLTSVYI 554
Query: 714 RGYKGLIGDDNYLALKNSQGKYLLNGHFVVS------AVERDLVVKGSLLRYSGTGTAVE 767
++ L +LA++ G+Y++ G +S ++ D V+ + +E
Sbjct: 555 ANHRPLF---THLAVRIG-GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLE 610
Query: 768 SLQASRPILEPLTVEVL-----SVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLH 822
++ P+ E ++V G +T P + ++++ PK
Sbjct: 611 EIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPK-------------------- 650
Query: 823 NSVLSLSNQVEQPDDRPPARWV-AGSWGPCSASCGSGLQKRAVDCRGSAGQ---RTVPAC 878
P WV A GPCS SCG+GL+ C A + TV
Sbjct: 651 ----------------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ 694
Query: 879 DAAHRPVETQACG-EPCPT-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLL-----ARD 931
+ P +AC EPCP W + + PCS SCG G + R ++CV G LL AR
Sbjct: 695 GSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARC 754
Query: 932 QCNLHRKPQELDFCVLRPC 950
+ + L+ C +PC
Sbjct: 755 RAGAQQPAVALETCNPQPC 773
Score = 70.1 bits (170), Expect = 9e-12
Identities = 43/118 (36%), Positives = 54/118 (45%), Gaps = 7/118 (5%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPACDAAHRPVETQAC--GEP 893
P RW S GPCSASCG G +R+V C +G + AC A RP + C +
Sbjct: 982 PPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
Query: 894 CPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRL-LARDQCNLHRKPQELDFCVLRPC 950
W + W CS SCG G QRR C+G + + D C KP + C PC
Sbjct: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/111 (35%), Positives = 48/111 (43%), Gaps = 9/111 (8%)
Query: 849 GPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRP-VETQAC-GEPCPTWELSAWSP 904
G CS SCG GL + C SA + V C A +P + C PCP +
Sbjct: 871 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAA 930
Query: 905 CSKSCGRGFQRRSLKCV-----GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
CS SCGRG RR L C G +L QC +P+ + C L PC
Sbjct: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPC 981
Score = 38.5 bits (88), Expect = 0.030
Identities = 35/147 (23%), Positives = 47/147 (31%), Gaps = 36/147 (24%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEPC----- 894
PARW C+++ G+GL C A P + E EPC
Sbjct: 774 PARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSC 833
Query: 895 -PTW------------------------ELSAWSP----CSKSCGRGFQRRSLKCVGHGG 925
P W W+P CS SCGRG C+
Sbjct: 834 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL 893
Query: 926 RLLARDQ-CNLHRKP-QELDFCVLRPC 950
R+ +++ C L KP + C PC
Sbjct: 894 RVPVQEELCGLASKPGSRREVCQAVPC 920
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 230 bits (587), Expect = 4e-60
Identities = 157/473 (33%), Positives = 203/473 (42%), Gaps = 79/473 (16%)
Query: 514 RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSS 573
R +W W + PCSRTCGGGV R C + +GG C G +RSC E CP
Sbjct: 24 RQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTESCPDG 82
Query: 574 ASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAP 633
A + FR EQC F+G R W+P YS + KC+L C G ++Y
Sbjct: 83 A--RDFRAEQCAEFDGAEFQGRRYR----WLPYYSAPN---KCELNCIPKGENFYYKHRE 133
Query: 634 KVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPM 693
VVDGT C P VCV G C GCD L S K+ DKC CGGD +C V G F
Sbjct: 134 AVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFD--- 190
Query: 694 HGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVK 753
+D A+KN +G+Y LNGH+ + A R L
Sbjct: 191 ---------------------------ANDLSRAVKNVRGEYYLNGHWTIEAA-RALPAA 222
Query: 754 GSLLRY---SGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLP-KEP----- 804
++L Y + A E L A P EPL +E++S + P V Y ++LP + P
Sbjct: 223 STILHYERGAEGDLAPERLHARGPTSEPLVIELIS--QEPNPGVHYEYHLPLRRPSPGFS 280
Query: 805 ----------REDKSSHPKDPRGPSVLHNSVLS-LSNQVEQPDDR---------PPARWV 844
E H ++ H + + + +P DR RW
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRWK 340
Query: 845 AGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAH------RPVETQACG-EPCPTW 897
AG W PCSASCG G Q R+V C S G A + A +P QAC + C W
Sbjct: 341 AGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAW 400
Query: 898 ELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W CS SCG G ++RS+ C G G LL C+L +P + CV C
Sbjct: 401 SPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDC 453
Score = 80.9 bits (198), Expect = 5e-15
Identities = 46/121 (38%), Positives = 57/121 (47%), Gaps = 18/121 (14%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRT-VPACDAAHRPVETQAC-GEPCP--- 895
A W WG CS SCG G++KR+V CRG G AC RP T+ C E CP
Sbjct: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLS 457
Query: 896 --TWELSAWSPCSKSCGRGFQRRSLKCV----GHGGRLLARDQCNLHRKPQELDFCVLRP 949
W + W CSKSC G +RR + C H G L H KP +++ C +P
Sbjct: 458 DQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSL-------QHSKPVDVEPCNTQP 510
Query: 950 C 950
C
Sbjct: 511 C 511
Score = 35.4 bits (80), Expect = 0.25
Identities = 44/199 (22%), Positives = 69/199 (34%), Gaps = 18/199 (9%)
Query: 399 RANPWSACSAAI--------ITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCEL 450
+A PW+ CSA+ + G G + ++ LP P Q C L
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAI-----QACNL 394
Query: 451 AFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCG-EGKLCLKGACVERHN 509
P P+ + C+ G K + C+ +C E + L CV H
Sbjct: 395 QRCAAWSPEPWGE-CSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV--HE 451
Query: 510 LNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEP 569
D +W +G CS++C G + + C P++ G V CN +P
Sbjct: 452 DCPLLSDQAWHV-GTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQP 510
Query: 570 CPSSASGKSFREEQCEAFN 588
C S ++ A N
Sbjct: 511 CHLPQEVPSMQDVHTPASN 529
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 206 bits (523), Expect = 1e-52
Identities = 158/464 (34%), Positives = 220/464 (47%), Gaps = 30/464 (6%)
Query: 44 GPEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFY 103
G E+ L + +T F D +L L P+A+ +AP + E G +G T L C Y
Sbjct: 100 GNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE--KGTTRVEPLLGSCLY 157
Query: 104 SGDVNAEPD-SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQG-AHLLQRRG 161
GDV + S A+S C GL G E+ I PL A AQ QG H++ RR
Sbjct: 158 VGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLA--AQEAEQGRVHVVYRRP 215
Query: 162 VPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRY-V 220
P G P + AS L +LD R G E + RA+R + Y +
Sbjct: 216 PTSPPLGGPQALDTGAS------LDSLDSLS-RALGVLEEHANSSRRRARRHAADDDYNI 268
Query: 221 ETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGP 279
E L+ D+S+V+FHG + ++ YLLTL+ +Y S+ IN+V+V+++LL S
Sbjct: 269 EVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS 328
Query: 280 KVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTM 338
+ GN + +L N C W K H EY D AI TRQD + G A V M
Sbjct: 329 LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYAPVTGM 385
Query: 339 CDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQID 398
C P RSC++ +DG SAF AHE GHV M HD ++R +M+P +
Sbjct: 386 CHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDEVRLGSIMAPLVQAAF 443
Query: 399 RANPWSACSAAIITDFLDSGHGDCLLDQPSKP--ISLPEDLPGASYTLSQQCELAFGVGS 456
WS CS ++ +L S DCLLD P +LP+ LPG Y++++QC FG+G
Sbjct: 444 HRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQ-LPGLHYSMNEQCRFDFGLGY 500
Query: 457 KPCPYMQY---CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGK 497
C + C +LWC+ C+T+ P DGT C GK
Sbjct: 501 MMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGK 543
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 200 bits (508), Expect = 6e-51
Identities = 144/484 (29%), Positives = 210/484 (43%), Gaps = 73/484 (15%)
Query: 516 DGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSAS 575
DG+W W + CSRTCGGG + R+C G+ CEG ++Y++C+ CP A
Sbjct: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDA- 127
Query: 576 GKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKV 635
+ FR +QC A+N + + W+P+Y+ P C L C A G LAPKV
Sbjct: 128 -EDFRAQQCSAYNDVQYQGHYYE----WLPRYN--DPAAPCALKCHAQGQNLVVELAPKV 180
Query: 636 VDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTG---LFTKP 692
+DGT C+ DS +C+ G C GCD LGS + D CGVC GD +C+ V G P
Sbjct: 181 LDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
Query: 693 MHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLN--GHFVV------- 743
V+A+P G+ S+ I +G L + L+ S+G++ N G F+V
Sbjct: 241 EKREENVIAVPLGSRSVRITVKGPAHLFIESK--TLQGSKGEHSFNSPGVFLVENTTVEF 298
Query: 744 --SAVERDLVVKGSLL-------RYSGTGTAVESLQASRPILE--------PLTVEV--- 783
+ + + G L+ RY+ +V +PI P TV
Sbjct: 299 QRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGG 358
Query: 784 --LSVGKMTPPRVR------YSFYLPK--EPREDKSSHPKDPRGPSVLHNSVLSLSNQVE 833
L+ + R++ Y Y P+ +P+ DP S ++ +
Sbjct: 359 YQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDH--- 415
Query: 834 QPDDRPPARWVAGSWGPCSASCGSGLQKRAVDC-----RGSAGQRTVPACDAAHRPVETQ 888
+P RW W CS SCG G+Q+R+ C G Q C A +P Q
Sbjct: 416 ---FQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQ 472
Query: 889 ACG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVL 947
C CP W WS C+ +CGRG + R + C+ H G + CN K + CV+
Sbjct: 473 TCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVG--GCNPQLKLHIKEECVI 530
Query: 948 R-PC 950
PC
Sbjct: 531 PIPC 534
Score = 73.9 bits (180), Expect = 6e-13
Identities = 35/83 (42%), Positives = 43/83 (51%), Gaps = 2/83 (2%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE-PCPT-W 897
P RW GSWGPCSA+CG G+Q R V C P +P QAC + CP W
Sbjct: 704 PPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGW 763
Query: 898 ELSAWSPCSKSCGRGFQRRSLKC 920
+ W CS++CG G Q R + C
Sbjct: 764 HIEEWQQCSRTCGGGTQNRRVTC 786
Score = 72.8 bits (177), Expect = 1e-12
Identities = 49/152 (32%), Positives = 66/152 (43%), Gaps = 7/152 (4%)
Query: 800 LPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPAR-WVAGSWGPCSASCGSG 858
LP+E E + P S S + P+D W + PC+A+C G
Sbjct: 604 LPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGG 663
Query: 859 LQKRAVDCRGSAGQRTV--PACDAAHRP-VETQACG-EPCPT-WELSAWSPCSKSCGRGF 913
Q+ C Q+TV CD HRP +QAC EPCP W + +W PCS +CG G
Sbjct: 664 HQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGI 723
Query: 914 QRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
Q R + C+ G ++C KP L C
Sbjct: 724 QTRDVYCLHPGETPAPPEECR-DEKPHALQAC 754
Score = 61.6 bits (148), Expect = 3e-09
Identities = 44/172 (25%), Positives = 57/172 (33%), Gaps = 61/172 (35%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVP-----ACDAAHRPVETQAC-GEP 893
PARW W CS SCG G R V C+ + TV AC RP+ + C G P
Sbjct: 1484 PARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHP 1543
Query: 894 C-----------------------------------------PT-------------WEL 899
C PT W
Sbjct: 1544 CVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHT 1603
Query: 900 SAWSPCSKSCGRGFQRRSLKCV-GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W PC+ +CGRGFQ R + C+ + +A+ C +KP C+ C
Sbjct: 1604 GPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 57.4 bits (137), Expect = 6e-08
Identities = 35/97 (36%), Positives = 45/97 (46%), Gaps = 14/97 (14%)
Query: 835 PDDRPPAR---WVAGSWGPCSASCGS-GLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQA 889
P PP + W G+W CSA+CG G + + C + GQ A CD +P+ A
Sbjct: 1417 PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPL---A 1473
Query: 890 CGEPC------PTWELSAWSPCSKSCGRGFQRRSLKC 920
EPC W S WS CS SCG G+ R + C
Sbjct: 1474 GFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTC 1510
Score = 52.0 bits (123), Expect = 3e-06
Identities = 32/90 (35%), Positives = 35/90 (38%), Gaps = 7/90 (7%)
Query: 837 DRPPARWVAGSWGPCSASCGSGLQKRAVDCR-----GSAGQRTVPACDAAHRPVETQACG 891
D PP W W CS +CG G Q R V CR GS + C
Sbjct: 758 DCPPG-WHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCAR 816
Query: 892 EPCPT-WELSAWSPCSKSCGRGFQRRSLKC 920
CP + WS CS SCG G QRR C
Sbjct: 817 TDCPPHLAVGDWSKCSVSCGVGIQRRKQVC 846
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/147 (25%), Positives = 52/147 (35%), Gaps = 40/147 (27%)
Query: 842 RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRT--------------------------- 874
+W+A W C+ +CG GL+ R V C G+
Sbjct: 481 KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEK 540
Query: 875 ------VPACDAAHRPVETQACGEPCPTWELSAWSPCSKSCGRGFQRRSLKC-----VGH 923
+P A ET+ E PT+ WS CS +CG G Q R +KC
Sbjct: 541 SPVEAKLPWLKQAQELEETRIATEE-PTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQ 599
Query: 924 GGRLLARDQCNLHRKPQELDFCVLRPC 950
L ++C + P E C+L C
Sbjct: 600 TETELPEEECEGPKLPTERP-CLLEAC 625
Score = 46.2 bits (108), Expect = 1e-04
Identities = 35/131 (26%), Positives = 50/131 (38%), Gaps = 28/131 (21%)
Query: 848 WGPCSASCGSGLQKRAVDCR------GSAGQRTVPACDA----AHRPVETQACGE----- 892
W CS +CG G+Q R V CR + + C+ RP +AC E
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASR 632
Query: 893 ----PCP-------TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQ-CNL-HRKP 939
P P WE + ++PC+ +C G Q C+ + D C++ HR P
Sbjct: 633 ELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPP 692
Query: 940 QELDFCVLRPC 950
C PC
Sbjct: 693 AMSQACNTEPC 703
Score = 38.9 bits (89), Expect = 0.023
Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 9/67 (13%)
Query: 515 VDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPAN--GGKYC----EGV--RVKYRSCN 566
+ W + D + PC+ TCGGG QL +C + YC E V + K + C+
Sbjct: 339 ISHQWRQTD-FFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECS 397
Query: 567 LEPCPSS 573
++PCPSS
Sbjct: 398 MDPCPSS 404
Score = 35.8 bits (81), Expect = 0.19
Identities = 26/84 (30%), Positives = 36/84 (42%), Gaps = 10/84 (11%)
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNP--TPANGGKYCEGVRVKYRSCNLEPCPSSA 574
GSW GPCS TCG G+Q C +P TPA + + ++CN CP
Sbjct: 710 GSW------GPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGW 763
Query: 575 SGKSFREEQCEAFNGYNHSTNRLT 598
+ + +QC G R+T
Sbjct: 764 HIEEW--QQCSRTCGGGTQNRRVT 785
Score = 34.7 bits (78), Expect = 0.43
Identities = 22/65 (33%), Positives = 33/65 (50%), Gaps = 5/65 (7%)
Query: 891 GEPCPT---WELSAWSPCSKSCGR-GFQRRSLKCVGHGGRLLARDQCNLHRKP-QELDFC 945
GEP P WE WS CS +CG G + + +CV G+ ++ C+ +KP + C
Sbjct: 1419 GEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPC 1478
Query: 946 VLRPC 950
+R C
Sbjct: 1479 NIRDC 1483
Score = 34.3 bits (77), Expect = 0.57
Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDC-RGSAGQRTVP 876
P G W CS SCG G+Q+R C R +A R +P
Sbjct: 820 PPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIP 857
Score = 33.9 bits (76), Expect = 0.74
Identities = 20/62 (32%), Positives = 29/62 (46%), Gaps = 7/62 (11%)
Query: 523 DPYGPCSRTCGGGVQLARRQC------TNPTPANGGKYCEGVRV-KYRSCNLEPCPSSAS 575
+P+ CS TCG GVQ+ +C T + CEG ++ R C LE C S +
Sbjct: 571 EPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPA 630
Query: 576 GK 577
+
Sbjct: 631 SR 632
Score = 32.7 bits (73), Expect = 1.7
Identities = 30/103 (29%), Positives = 40/103 (38%), Gaps = 25/103 (24%)
Query: 454 VGSKPC---PYMQYCTKLWCTGKAKGQMV-CQTRHFPWADGTS---CGEGKL------CL 500
+G KPC P +Q+ C G+ G+ V Q RH +S C + K C
Sbjct: 1534 LGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCT 1593
Query: 501 KGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQC 543
GAC D W P+ PC+ CG G Q + C
Sbjct: 1594 SGAC-----------DVCWHT-GPWKPCTAACGRGFQSRKVDC 1624
Score = 32.0 bits (71), Expect = 2.8
Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 6/50 (12%)
Query: 528 CSRTCGGGVQLARRQC----TNPTPAN-GGKYCEGVRV-KYRSCNLEPCP 571
CSRTCGGG Q R C T+ + N + C+G + ++SC CP
Sbjct: 771 CSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCP 820
Score = 31.6 bits (70), Expect = 3.7
Identities = 20/80 (25%), Positives = 34/80 (42%), Gaps = 4/80 (5%)
Query: 797 SFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVA-GSWGPCSASC 855
+++LP+ + S +D G L +++ + D+ W A G W CS +C
Sbjct: 32 AYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSRNTRSDEDKDGNWDAWGDWSDCSRTC 91
Query: 856 GSGLQ---KRAVDCRGSAGQ 872
G G +R + R GQ
Sbjct: 92 GGGASYSLRRCLTGRNCEGQ 111
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 193 bits (491), Expect = 6e-49
Identities = 144/487 (29%), Positives = 206/487 (42%), Gaps = 79/487 (16%)
Query: 516 DGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSAS 575
DG W W P+ CSRTCGGG + R+C + K CEG ++YR+C+ CP A
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 576 GKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKV 635
FR +QC A N H W+P + P + C L C+A GT LAPKV
Sbjct: 87 --DFRAQQCSAHNDVKHHGQ----FYEWLPVSN--DPDNPCSLKCQAKGTTLVVELAPKV 138
Query: 636 VDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHG 695
+DGT C +S +C+ G C GCD LGS + D CGVC GD +C+ V G + +
Sbjct: 139 LDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
Query: 696 Y---NFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVV--SAVE--- 747
+ VVAIP G+ I + +G L + L + G F+V S+V+
Sbjct: 199 TKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQK 258
Query: 748 --------------RDLVVKGSLLRYSGTGTAVESLQASRPIL----------------- 776
D +VK +R SG+ + +PI+
Sbjct: 259 FPDKEILRMAGPLTADFIVK---IRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG 315
Query: 777 --EPLTVEVLSVGKMTPPRVRYSFYLPK--EPREDKSSHPKDPRGPSVLHNSVLSLSNQV 832
+ + E + +Y Y P+ +P+ DP S + ++
Sbjct: 316 GYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM------ 369
Query: 833 EQPDD--RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-----CDAAHRPV 885
P D P RW A W CS+SCG G+Q RAV C Q V + C +
Sbjct: 370 --PYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMP 427
Query: 886 ETQACG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDF 944
Q C CP W WSPC+ +CG+G + R + C+ H G + C+ KP +
Sbjct: 428 IAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEE 485
Query: 945 CVL-RPC 950
C++ PC
Sbjct: 486 CIVPTPC 492
Score = 72.0 bits (175), Expect = 2e-12
Identities = 41/121 (33%), Positives = 57/121 (47%), Gaps = 10/121 (8%)
Query: 840 PARWVAGSWGPCSASCGSGLQKRAVDCR--GSAGQRTVPACD----AAHRPVETQACGEP 893
P+RW+ SW C+ SCG G+Q R V C+ ++G T + D A RPV+TQAC +
Sbjct: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
Query: 894 -CPTWELSAWSPCSKSC---GRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRP 949
C W S+W C+ C Q R + C G L +QC+ +P C
Sbjct: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
Query: 950 C 950
C
Sbjct: 1666 C 1666
Score = 70.1 bits (170), Expect = 9e-12
Identities = 39/92 (42%), Positives = 46/92 (50%), Gaps = 8/92 (8%)
Query: 837 DRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQ---RTVPACDAAHR---PVETQAC 890
D PARW G W PCS +CG GLQ R V C + TV D R P QAC
Sbjct: 664 DPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQAC 723
Query: 891 GE-PC-PTWELSAWSPCSKSCGRGFQRRSLKC 920
C P W + W PCS++CG G Q+R + C
Sbjct: 724 NRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC 755
Score = 68.9 bits (167), Expect = 2e-11
Identities = 40/89 (44%), Positives = 49/89 (55%), Gaps = 9/89 (10%)
Query: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCR-----GSAGQRTVPACDAAHRPVETQAC-GE 892
PPA W W PCS +CG G+QKR V C+ GS + C A+ +P QAC +
Sbjct: 729 PPA-WYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSAS-KPACQQACKKD 786
Query: 893 PCPT-WELSAWSPCSKSCGRGFQRRSLKC 920
CP+ W LS W+ CS SCG G Q RS C
Sbjct: 787 DCPSEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 63.5 bits (153), Expect = 9e-10
Identities = 40/117 (34%), Positives = 56/117 (47%), Gaps = 10/117 (8%)
Query: 843 WVAGSWGPCSASCGS---GLQKRAVDCRGSAGQRTVPA--CDAAHRPVETQAC-GEPCPT 896
W SWG C+ C +Q R V C+ G T+P+ C A RPV TQ C E C
Sbjct: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI-TLPSEQCSALPRPVSTQNCWSEACSV 1668
Query: 897 -WELSAWSPCSKSCGR-GFQRRSLKCV-GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W +S W+ C+ +CG GFQ R ++CV + + C+ +P C + PC
Sbjct: 1669 HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
Score = 51.6 bits (122), Expect = 3e-06
Identities = 29/82 (35%), Positives = 44/82 (53%), Gaps = 4/82 (4%)
Query: 843 WVAGSWGPCSASCGS-GLQKRAVDCRGSAGQRTVPACDAAHRP-VETQACG-EPCPT-WE 898
W CSASCG+ G+Q+ + C ++ + C RP V+ AC CP+ W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 899 LSAWSPCSKSCGRGFQRRSLKC 920
+++WS C++SCG G Q R + C
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTC 1572
Score = 50.1 bits (118), Expect = 1e-05
Identities = 48/196 (24%), Positives = 68/196 (34%), Gaps = 42/196 (21%)
Query: 790 TPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQV-EQPDDRPPARWVAGSW 848
T P ++ +P + K P + + P L V E+P P A W
Sbjct: 478 TKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEA------W 531
Query: 849 GPCSASCGSGLQKRAVDCR------GSAGQRTVPACDAAHRPVETQAC-GEPCP------ 895
C+ +CG G Q R V C+ S + C+ +P +AC PC
Sbjct: 532 SACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGP-KPASQRACYAGPCSGEIPEF 590
Query: 896 -------------------TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQ--CN 934
WE ++ CS+SCG G Q + C+ R A +
Sbjct: 591 NPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVT 650
Query: 935 LHRKPQELDFCVLRPC 950
R PQ L C L PC
Sbjct: 651 SRRPPQLLKSCNLDPC 666
Score = 38.5 bits (88), Expect = 0.030
Identities = 28/101 (27%), Positives = 39/101 (38%), Gaps = 17/101 (16%)
Query: 489 DGTSCGEGKLCLKGACV-ERHNLNKHRVDGSWA-----------KWDPYGPCSRTCGGGV 536
+G + C G C E N DG + +++ + CS +CGGGV
Sbjct: 568 EGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGV 627
Query: 537 QLARRQCTN-----PTPANGGKYCEGVRVKYRSCNLEPCPS 572
Q A C N P N +SCNL+PCP+
Sbjct: 628 QEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPA 668
Score = 37.7 bits (86), Expect = 0.051
Identities = 14/31 (45%), Positives = 17/31 (54%)
Query: 837 DRPPARWVAGSWGPCSASCGSGLQKRAVDCR 867
D P+ W+ W CS SCG G Q R+ CR
Sbjct: 786 DDCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
Score = 33.1 bits (74), Expect = 1.3
Identities = 23/71 (32%), Positives = 32/71 (45%), Gaps = 13/71 (18%)
Query: 511 NKHRVDGSW--AKWDPYGPCSRTCGGGVQLARRQCTNPTPANGG------KYCEGVR-VK 561
N+ +W A+W P CSRTCGGGVQ C A+G +C +
Sbjct: 724 NRFNCPPAWYPAQWQP---CSRTCGGGVQKREVLC-KQRMADGSFLELPETFCSASKPAC 779
Query: 562 YRSCNLEPCPS 572
++C + CPS
Sbjct: 780 QQACKKDDCPS 790
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 193 bits (491), Expect = 6e-49
Identities = 144/487 (29%), Positives = 206/487 (42%), Gaps = 79/487 (16%)
Query: 516 DGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSAS 575
DG W W P+ CSRTCGGG + R+C + K CEG ++YR+C+ CP A
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 576 GKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKV 635
FR +QC A N H W+P + P + C L C+A GT LAPKV
Sbjct: 87 --DFRAQQCSAHNDVKHHGQ----FYEWLPVSN--DPDNPCSLKCQAKGTTLVVELAPKV 138
Query: 636 VDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHG 695
+DGT C +S +C+ G C GCD LGS + D CGVC GD +C+ V G + +
Sbjct: 139 LDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSA 198
Query: 696 Y---NFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVV--SAVE--- 747
+ VVAIP G+ I + +G L + L + G F+V S+V+
Sbjct: 199 TKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQK 258
Query: 748 --------------RDLVVKGSLLRYSGTGTAVESLQASRPIL----------------- 776
D +VK +R SG+ + +PI+
Sbjct: 259 FPDKEILRMAGPLTADFIVK---IRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGG 315
Query: 777 --EPLTVEVLSVGKMTPPRVRYSFYLPK--EPREDKSSHPKDPRGPSVLHNSVLSLSNQV 832
+ + E + +Y Y P+ +P+ DP S + ++
Sbjct: 316 GYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM------ 369
Query: 833 EQPDD--RPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-----CDAAHRPV 885
P D P RW A W CS+SCG G+Q RAV C Q V + C +
Sbjct: 370 --PYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMP 427
Query: 886 ETQACG-EPCPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDF 944
Q C CP W WSPC+ +CG+G + R + C+ H G + C+ KP +
Sbjct: 428 IAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEE 485
Query: 945 CVL-RPC 950
C++ PC
Sbjct: 486 CIVPTPC 492
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 190 bits (483), Expect = 5e-48
Identities = 142/439 (32%), Positives = 196/439 (44%), Gaps = 62/439 (14%)
Query: 555 CEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRD 614
C G + R+C+ PCP R QC AFN S + W P ++ V
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDP--RALQCAAFN----SQEFMGQLYQWEP-FTEVQGSQ 416
Query: 615 KCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGV 674
+C+L CR G ++ KV DGTLC P + +CV G+C+ GCDG LGS +R D CGV
Sbjct: 417 RCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGV 476
Query: 675 CGGDNKSCKKVTGLFTK---PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNS 731
CGGD+ +C+ V+G T P+ GY ++ IPAGA + I Q L NYLAL+
Sbjct: 477 CGGDDSTCRLVSGNLTDRGGPL-GYQKILWIPAGALRLQIAQ-----LRPSSNYLALRGP 530
Query: 732 QGKYLLNGHFVVSAVERDLVVKGSLLRYS------GTGTAVESLQASRPILEPLTVEVLS 785
G+ ++NG++ V G++ RY+ G G ESL A P +P V+V
Sbjct: 531 GGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREEGKG---ESLSAEGPTTQP--VDVYM 584
Query: 786 VGKMTPPRVRYSFYLPKEPREDKSSHPKDP----------------------RGPSVLHN 823
+ + P V Y + + P ++ P+ P R P L
Sbjct: 585 IFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQR 644
Query: 824 SV----LSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDC--RGSAGQRTVPA 877
V + P P A W CSASCG G+ + C R S + +
Sbjct: 645 QVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERS 704
Query: 878 CDAAHR-PVETQAC-GEPCPT-WELSAWSPCSKSCGRGFQRRSLKC---VGHGGRLLARD 931
C A R P + C G PCP WE W+ CS+SCG G Q R L+C G GG + +
Sbjct: 705 CAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPE 764
Query: 932 QCNLHRKPQELDFCVLRPC 950
+C +P C LR C
Sbjct: 765 RCGHLPRPNITQSCQLRLC 783
Score = 75.5 bits (184), Expect = 2e-13
Identities = 43/115 (37%), Positives = 55/115 (47%), Gaps = 8/115 (6%)
Query: 842 RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQR---TVPA-CDAAHRPVETQAC-GEPC-P 895
RW G WG CS+ CGSG Q+R + C G T P+ C RP Q C G+ C
Sbjct: 913 RWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQD 972
Query: 896 TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W + WSPCS+SC G Q R ++C+ L R C +P C +PC
Sbjct: 973 RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTR--CPPQLRPSRKRPCNSQPC 1025
Score = 65.5 bits (158), Expect = 2e-10
Identities = 43/123 (34%), Positives = 52/123 (42%), Gaps = 15/123 (12%)
Query: 843 WVAGS-WGPCSASCGSGLQKRAVDCRGSAGQRTVP--ACDAAHRPVETQACGE-PCPT-W 897
W GS W CS CG G + R V C G+ G +P +AC PC T W
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAW 845
Query: 898 ELSAWSP-CSKSCGRGFQRRSLKCVGHGGRL---------LARDQCNLHRKPQELDFCVL 947
S WS CS CG G QRRS+ C+G G L C +P ++ C L
Sbjct: 846 FHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSL 905
Query: 948 RPC 950
PC
Sbjct: 906 GPC 908
Score = 37.7 bits (86), Expect = 0.051
Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 497 KLCLKGACVERHNLNKHRVDGS-----WAKWDPYGPCSRTCGGGVQLARRQCTNPT 547
+LCL + H+L +G W W + CS+ CG GVQ R C PT
Sbjct: 20 QLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
Score = 36.2 bits (82), Expect = 0.15
Identities = 17/48 (35%), Positives = 24/48 (50%), Gaps = 1/48 (2%)
Query: 524 PYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR-VKYRSCNLEPC 570
P+ PCSR+C GG Q QC + + +R + R CN +PC
Sbjct: 978 PWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPC 1025
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 190 bits (483), Expect = 5e-48
Identities = 142/439 (32%), Positives = 196/439 (44%), Gaps = 62/439 (14%)
Query: 555 CEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRD 614
C G + R+C+ PCP R QC AFN S + W P ++ V
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDP--RALQCAAFN----SQEFMGQLYQWEP-FTEVQGSQ 416
Query: 615 KCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGV 674
+C+L CR G ++ KV DGTLC P + +CV G+C+ GCDG LGS +R D CGV
Sbjct: 417 RCELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGV 476
Query: 675 CGGDNKSCKKVTGLFTK---PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNS 731
CGGD+ +C+ V+G T P+ GY ++ IPAGA + I Q L NYLAL+
Sbjct: 477 CGGDDSTCRLVSGNLTDRGGPL-GYQKILWIPAGALRLQIAQ-----LRPSSNYLALRGP 530
Query: 732 QGKYLLNGHFVVSAVERDLVVKGSLLRYS------GTGTAVESLQASRPILEPLTVEVLS 785
G+ ++NG++ V G++ RY+ G G ESL A P +P V+V
Sbjct: 531 GGRSIINGNWAVDP-PGSYRAGGTVFRYNRPPREEGKG---ESLSAEGPTTQP--VDVYM 584
Query: 786 VGKMTPPRVRYSFYLPKEPREDKSSHPKDP----------------------RGPSVLHN 823
+ + P V Y + + P ++ P+ P R P L
Sbjct: 585 IFQEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQR 644
Query: 824 SV----LSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDC--RGSAGQRTVPA 877
V + P P A W CSASCG G+ + C R S + +
Sbjct: 645 QVRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERS 704
Query: 878 CDAAHR-PVETQAC-GEPCPT-WELSAWSPCSKSCGRGFQRRSLKC---VGHGGRLLARD 931
C A R P + C G PCP WE W+ CS+SCG G Q R L+C G GG + +
Sbjct: 705 CAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPE 764
Query: 932 QCNLHRKPQELDFCVLRPC 950
+C +P C LR C
Sbjct: 765 RCGHLPRPNITQSCQLRLC 783
Score = 37.7 bits (86), Expect = 0.051
Identities = 19/56 (33%), Positives = 25/56 (44%), Gaps = 5/56 (8%)
Query: 497 KLCLKGACVERHNLNKHRVDGS-----WAKWDPYGPCSRTCGGGVQLARRQCTNPT 547
+LCL + H+L +G W W + CS+ CG GVQ R C PT
Sbjct: 20 QLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPT 75
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 179 bits (453), Expect = 1e-44
Identities = 138/461 (29%), Positives = 207/461 (44%), Gaps = 80/461 (17%)
Query: 555 CEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRD 614
C G +Y+ CN CP S+ +S RE QC ++N + W P ++ V
Sbjct: 291 CIGAYRQYKLCNTNVCPESS--RSIREVQCASYNNKPF----MGRFYEWEP-FAEVKGNR 343
Query: 615 KCKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGV 674
KC+L C+A G ++ A KV+DGT C + T++CV G+C GCD LGS K DKCGV
Sbjct: 344 KCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGV 403
Query: 675 CGGDNKSCKKVTGLFTKPMH--GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQ 732
CGGDN C+ V+G+F + GY+ VV IP GA+ I+I + YK +NYLAL++
Sbjct: 404 CGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEM-YK----SNNYLALRSRS 458
Query: 733 GKYLLNGHFVVSAVERDLVVKGSLLRYSG----TGTAVESLQASRPILEPLTVEVLSVGK 788
G+ ++NG++ + + G++ Y + TA ES A P E L +V + +
Sbjct: 459 GRSIINGNWAIDRPGK-YEGGGTMFTYKRPNEISSTAGESFLAEGPTNEIL--DVYMIHQ 515
Query: 789 MTPPRVRYSFYL---------------PKEP----------------REDKSSHPKDPRG 817
P V Y + + P EP ++ ++ +D RG
Sbjct: 516 QPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRG 575
Query: 818 PS-VLHNSVLSLSNQVEQPD--------------DRPPAR-----WVAGSWGPCSASCGS 857
+ + S + + V PD +PP R W CS +CG
Sbjct: 576 EAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGK 635
Query: 858 GLQKRAVDCRGSAGQRTVPA--CDAAHRPV-ETQACG-EPCPT-WELSAWSPCSKSCGRG 912
G Q C + P CD++ +P E + C PCP W++ WS CSK+CG G
Sbjct: 636 GSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLG 695
Query: 913 FQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Q R + C + + +C KP+ C L+ C
Sbjct: 696 MQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
Score = 83.2 bits (204), Expect = 1e-15
Identities = 42/134 (31%), Positives = 67/134 (50%), Gaps = 12/134 (8%)
Query: 829 SNQVEQPDDRP------PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA----C 878
S+ P++ P PA W G W CS +CG G+Q R V CR R++ C
Sbjct: 660 SSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRC 719
Query: 879 DAAHRPVETQACG-EPCPTWELSA-WSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLH 936
+P T C + C W++ W+ CS CG G + R +KCV + G ++ ++CN+
Sbjct: 720 QHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMK 779
Query: 937 RKPQELDFCVLRPC 950
+P +++ C + PC
Sbjct: 780 LRPNDIENCDMGPC 793
Score = 72.0 bits (175), Expect = 2e-12
Identities = 42/114 (36%), Positives = 58/114 (50%), Gaps = 8/114 (7%)
Query: 843 WVAGSWGPCSASCGSGLQKRAVDC-RGSAGQRTV---PACDAAHRPVETQACG-EPC-PT 896
W AGSW CS CGSG Q+R V C R +A V C +P Q+C +PC
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAK 915
Query: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
W + WS CSKSC GF+ R ++C+ + + C+ KP+E + C + C
Sbjct: 916 WFSTEWSMCSKSCQGGFRVREVRCLSDD--MTLSNLCDPQLKPEERESCNPQDC 967
Score = 66.6 bits (161), Expect = 1e-10
Identities = 43/131 (32%), Positives = 58/131 (44%), Gaps = 11/131 (8%)
Query: 830 NQVEQPDDRPPAR-WVAGSWGP-CSASCGSGLQKRAVDC-RGSAGQRTVPACDAAHRPVE 886
N +E D P A+ W W CSA CG+G++ R+V C + C +RP E
Sbjct: 783 NDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGC-GNNRPAE 841
Query: 887 TQACGE-PCP---TWELSAWSPCSKSCGRGFQRRSLKCVGHGG---RLLARDQCNLHRKP 939
C PC W +WS CS CG G Q+R + CV +L +C+ KP
Sbjct: 842 ATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKP 901
Query: 940 QELDFCVLRPC 950
C L+PC
Sbjct: 902 PSQQSCHLKPC 912
Score = 37.0 bits (84), Expect = 0.087
Identities = 13/27 (48%), Positives = 15/27 (55%)
Query: 517 GSWAKWDPYGPCSRTCGGGVQLARRQC 543
G W W P+ CSR+C GGV R C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 35.4 bits (80), Expect = 0.25
Identities = 17/50 (34%), Positives = 23/50 (46%), Gaps = 1/50 (2%)
Query: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC 890
A+W + W CS SC G + R V C S CD +P E ++C
Sbjct: 914 AKWFSTEWSMCSKSCQGGFRVREVRCL-SDDMTLSNLCDPQLKPEERESC 962
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,055,740
Number of Sequences: 37866
Number of extensions: 2275535
Number of successful extensions: 6487
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 5102
Number of HSP's gapped (non-prelim): 753
length of query: 950
length of database: 18,247,518
effective HSP length: 112
effective length of query: 838
effective length of database: 14,006,526
effective search space: 11737468788
effective search space used: 11737468788
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.