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Search of human proteins with 21265043
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21265043 ADAM metallopeptidase with thrombospondin type 1
motif, 13 isoform 3 preproprotein [Homo sapiens]
(1340 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 2828 0.0
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 2812 0.0
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 2767 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 385 e-106
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 374 e-103
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 367 e-101
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 358 2e-98
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 352 1e-96
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 330 6e-90
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 325 2e-88
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 321 3e-87
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 320 4e-87
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 317 5e-86
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 313 5e-85
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 312 1e-84
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 310 5e-84
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 303 6e-82
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 287 4e-77
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 268 3e-71
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 259 2e-68
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 248 4e-65
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 245 2e-64
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 244 3e-64
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 241 4e-63
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 220 6e-57
gi|145309328 papilin [Homo sapiens] 200 9e-51
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 164 5e-40
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 153 9e-37
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 125 4e-28
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 124 5e-28
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 2828 bits (7332), Expect = 0.0
Identities = 1340/1340 (100%), Positives = 1340/1340 (100%)
Query: 1 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 60
MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
Sbjct: 1 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 60
Query: 61 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 120
PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
Sbjct: 61 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 120
Query: 121 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 180
GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
Sbjct: 121 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 180
Query: 181 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 240
FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
Sbjct: 181 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 240
Query: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSANEQCRVAFGPKAVACTFAREHLDM 300
GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSANEQCRVAFGPKAVACTFAREHLDM
Sbjct: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSANEQCRVAFGPKAVACTFAREHLDM 300
Query: 301 CQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWG 360
CQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWG
Sbjct: 301 CQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWG 360
Query: 361 PRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA 420
PRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA
Sbjct: 361 PRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA 420
Query: 421 RTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPS 480
RTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPS
Sbjct: 421 RTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPS 480
Query: 481 GPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYV 540
GPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYV
Sbjct: 481 GPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYV 540
Query: 541 TFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVA 600
TFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVA
Sbjct: 541 TFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVA 600
Query: 601 LTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAV 660
LTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAV
Sbjct: 601 LTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAV 660
Query: 661 RGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDF 720
RGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDF
Sbjct: 661 RGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDF 720
Query: 721 GPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVS 780
GPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVS
Sbjct: 721 GPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVS 780
Query: 781 EPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHL 840
EPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHL
Sbjct: 781 EPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHL 840
Query: 841 DATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEE 900
DATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEE
Sbjct: 841 DATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEE 900
Query: 901 LCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILL 960
LCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILL
Sbjct: 901 LCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILL 960
Query: 961 DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD 1020
DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD
Sbjct: 961 DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD 1020
Query: 1021 EAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD 1080
EAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD
Sbjct: 1021 EAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD 1080
Query: 1081 FCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTL 1140
FCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTL
Sbjct: 1081 FCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTL 1140
Query: 1141 RVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYG 1200
RVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYG
Sbjct: 1141 RVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYG 1200
Query: 1201 SQLAPETFYRECDMQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMG 1260
SQLAPETFYRECDMQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMG
Sbjct: 1201 SQLAPETFYRECDMQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMG 1260
Query: 1261 AGTEGANASYILIRDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWT 1320
AGTEGANASYILIRDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWT
Sbjct: 1261 AGTEGANASYILIRDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWT 1320
Query: 1321 LQSWVPEMQDPQSWKGKEGT 1340
LQSWVPEMQDPQSWKGKEGT
Sbjct: 1321 LQSWVPEMQDPQSWKGKEGT 1340
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 2812 bits (7290), Expect = 0.0
Identities = 1340/1371 (97%), Positives = 1340/1371 (97%), Gaps = 31/1371 (2%)
Query: 1 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 60
MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
Sbjct: 1 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 60
Query: 61 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 120
PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
Sbjct: 61 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 120
Query: 121 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 180
GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
Sbjct: 121 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 180
Query: 181 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 240
FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
Sbjct: 181 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 240
Query: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA------------------------ 276
GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA
Sbjct: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 300
Query: 277 -------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 329
NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
Sbjct: 301 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 360
Query: 330 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 389
GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
Sbjct: 361 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 420
Query: 390 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 449
RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
Sbjct: 421 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 480
Query: 450 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 509
ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
Sbjct: 481 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 540
Query: 510 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 569
VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
Sbjct: 541 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 600
Query: 570 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 629
GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
Sbjct: 601 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 660
Query: 630 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 689
YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
Sbjct: 661 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 720
Query: 690 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 749
TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
Sbjct: 721 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 780
Query: 750 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 809
PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
Sbjct: 781 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 840
Query: 810 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 869
PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
Sbjct: 841 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 900
Query: 870 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 929
AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
Sbjct: 901 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 960
Query: 930 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 989
ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 1020
Query: 990 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1049
LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
Sbjct: 1021 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1080
Query: 1050 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQH 1109
WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQH
Sbjct: 1081 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQH 1140
Query: 1110 LEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRK 1169
LEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRK
Sbjct: 1141 LEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRK 1200
Query: 1170 LLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLS 1229
LLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLS
Sbjct: 1201 LLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLS 1260
Query: 1230 PATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQV 1289
PATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQV
Sbjct: 1261 PATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQV 1320
Query: 1290 LYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1340
LYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
Sbjct: 1321 LYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1371
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 2767 bits (7173), Expect = 0.0
Identities = 1335/1427 (93%), Positives = 1335/1427 (93%), Gaps = 87/1427 (6%)
Query: 1 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 60
MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
Sbjct: 1 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP 60
Query: 61 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 120
PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
Sbjct: 61 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL 120
Query: 121 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 180
GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
Sbjct: 121 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR 180
Query: 181 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 240
FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
Sbjct: 181 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS 240
Query: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA------------------------ 276
GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA
Sbjct: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 300
Query: 277 -------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 329
NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
Sbjct: 301 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC 360
Query: 330 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 389
GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
Sbjct: 361 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG 420
Query: 390 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 449
RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
Sbjct: 421 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD 480
Query: 450 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 509
ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
Sbjct: 481 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 540
Query: 510 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 569
VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
Sbjct: 541 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 600
Query: 570 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 629
GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
Sbjct: 601 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 660
Query: 630 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 689
YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
Sbjct: 661 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 720
Query: 690 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 749
TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
Sbjct: 721 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL 780
Query: 750 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 809
PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
Sbjct: 781 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA 840
Query: 810 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 869
PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
Sbjct: 841 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA 900
Query: 870 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 929
AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
Sbjct: 901 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA 960
Query: 930 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 989
ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 1020
Query: 990 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1049
LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
Sbjct: 1021 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT 1080
Query: 1050 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG------ 1103
WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG
Sbjct: 1081 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP 1140
Query: 1104 -----ACGRQHLEP---------------------------------------------T 1113
A GR P T
Sbjct: 1141 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT 1200
Query: 1114 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1173
GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
Sbjct: 1201 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM 1260
Query: 1174 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1233
TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS
Sbjct: 1261 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS 1320
Query: 1234 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1293
NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE
Sbjct: 1321 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE 1380
Query: 1294 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1340
SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
Sbjct: 1381 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT 1427
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 385 bits (990), Expect = e-106
Identities = 328/1212 (27%), Positives = 473/1212 (39%), Gaps = 238/1212 (19%)
Query: 44 QAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERY 103
+ V + S PLK +R+ R++R ++E++V V AH + + Y
Sbjct: 230 ERVLGHTSKNVPLKD-------ERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNY 282
Query: 104 VLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINP 163
+LT ++I A + +DPS+G + +VK+V++ E P I + ++L + C W QT N
Sbjct: 283 ILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQND 342
Query: 164 EDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIA 223
DD P H D + ITR D+ + G++ LG C P SC I E+ G TIA
Sbjct: 343 LDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIA 402
Query: 224 HEIGHSFGLEHDGAPGSGCGPSG----HVMASDGAAPRAGLAWSPCSRRQLLSLLSA--- 276
HE+GH+ G++HD P C HVMA + + +WS CSR+ + L
Sbjct: 403 HELGHTLGVQHDDNPR--CKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYG 460
Query: 277 -------------------------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPL 311
N+QC +AFGP + C H+++C L C +
Sbjct: 461 ECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCP----HINICMHLWCTSTEK 516
Query: 312 DQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGG 371
C VP DGT+CG C G C + + T V+G W W P S CSR+CGG
Sbjct: 517 LHKGCFTQHVPPADGTDCGPGMHCRHGLCVN--KETETRPVNGEWGPWEPYSSCSRTCGG 574
Query: 372 GVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSP 431
G+ + R+CN P P GG CVG ++ CNT +C K +F +QC+ +G+ L S
Sbjct: 575 GIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDIS- 633
Query: 432 GGASFYHWGAAVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTL 488
G S W +P G C+ C+ G ++ D DGT C T
Sbjct: 634 GIPSNVRW---LPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTE------TH 684
Query: 489 SLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPN 548
+CV G C GCD ++S D+C VCGGDNS+C G F + Y + +
Sbjct: 685 DICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSH-YGYNVVVKIPAG 743
Query: 549 LTSV----YIANHRPLFTHLAVR-IGGRYVVAGKMSISPN----------TTYPSLLEDG 593
T+V Y + +P ++LA+ G ++ G +S + T +
Sbjct: 744 ATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNN 803
Query: 594 RVEYRVALTEDRLPRLEEIRIWG-------------PLQEDADIQVYRRYGEEYG----- 635
VE + + ++ G PL+E +D+ + YG G
Sbjct: 804 AVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMC 863
Query: 636 -NLTRPDITFTYFQPK-----------PRQAWV-----------WAAV-RGPCSVSCGAG 671
L R +IT + P ++V W + + CS CG G
Sbjct: 864 QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQG 923
Query: 672 LRWVNYSCLDQARKELVETVQCQ----GSQQPPAWPEACVLEPCPPYWAVGDFGPCSASC 727
R ++ C+ + E +TVQ G Q P E C W ++ CS SC
Sbjct: 924 YRTLDIHCMKYSIHE-GQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSC 982
Query: 728 GGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTS 787
GGG R R C+ G L C+ + V E CN CP+ W SE S C
Sbjct: 983 GGGERSRESYCMNNFG---HRLADNECQ---ELSRVTRENCNEFSCPS-WAASEWSECLV 1035
Query: 788 AGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGE 847
G G C D L ++G + K + PC +C W
Sbjct: 1036 TCGKGTKQRQVWCQLNVDHL----SDGFCNSSTKPESLSPCELHTC-ASW---------- 1080
Query: 848 KAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASK 907
PW G C+ +CG G C++ +++ C AS+
Sbjct: 1081 -QVGPW-----------------GPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASR 1122
Query: 908 PGSRREVCQAVPCP------------------ARWQY-KLAACSVSCGRGVVRRILYCAR 948
P S R+ C PC A+W++ CSVSCGRG R + C
Sbjct: 1123 P-SDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC-- 1179
Query: 949 AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVAC 1008
D + I ++ C LPRP C PC W+ PCSASCG G R V C
Sbjct: 1180 ---RDALDRIADESYCAHLPRPAEIWDC-FTPC-GEWQAGDWSPCSASCGHGKTTRQVLC 1234
Query: 1009 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCT-------------------------- 1042
+ Q +DE C VRP C +A C
Sbjct: 1235 MNYHQ----PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQK 1290
Query: 1043 ---------------YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK 1087
+W G W CS SC G+Q R C Q+ A +C K
Sbjct: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQS---ASYCDAASK 1347
Query: 1088 PVTVRGCWAGPC 1099
P ++ C GPC
Sbjct: 1348 PPELQQCGPGPC 1359
Score = 121 bits (303), Expect = 5e-27
Identities = 112/454 (24%), Positives = 179/454 (39%), Gaps = 62/454 (13%)
Query: 662 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFG 721
G CS SC GL+ C D+ + C + +PP + C PCP W G++G
Sbjct: 1314 GSCSSSCSGGLQHRAVVCQDENGQS---ASYCDAASKPPELQQ-CGPGPCPQ-WNYGNWG 1368
Query: 722 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA--RWEV 779
CS +CGGG++ R V C G +L+ C + P+V C+ CPA W
Sbjct: 1369 ECSQTCGGGIKSRLVICQFPNGQILE---DHNCEIVNKPPSVI--QCHMHACPADVSWHQ 1423
Query: 780 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 839
+SC+++ G G C+ D + + + S +K P + C + C P W
Sbjct: 1424 EPWTSCSASCGKGRKYREVFCI---DQFQRKLEDTNCSQVQKPPTHKACRSVRC-PSW-- 1477
Query: 840 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 899
A+ W CSV+CG G+ + C + V E
Sbjct: 1478 ----------------------KANSW----NECSVTCGSGVQQRDVYCRLKGVG-QVVE 1510
Query: 900 ELCGLASKPGSRREVCQAVPCPAR--WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 957
E+C +++P S+R C + C + CS SC R + + C + E
Sbjct: 1511 EMCDQSTRPCSQRR-CWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECT-DNQIRQVNE 1568
Query: 958 ILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV 1017
I+ ++ L + C PC C+ +CG +R C ++ +
Sbjct: 1569 IVYNSSTISL----TSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKH 1624
Query: 1018 EVDEAACAAL----VRPEASVPCLIADCTY--RWHVGTWMECSVSCGDGIQRRRDTCLGP 1071
++ V P + V I C + W VG W +CSV+CG GI +R+ C+
Sbjct: 1625 KLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI-- 1682
Query: 1072 QAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGAC 1105
+ + +D C + KP + C+A C C
Sbjct: 1683 -TKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTC 1715
Score = 110 bits (275), Expect = 9e-24
Identities = 120/506 (23%), Positives = 178/506 (35%), Gaps = 108/506 (21%)
Query: 641 DITFTYFQPKPRQAW-------VWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQ 692
D ++ P+P + W W A PCS SCG G C++ + ++
Sbjct: 1188 DESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQP--IDENY 1245
Query: 693 CQGSQQPPAWPEACVLEPCPP--------------------------------------- 713
C +P + C L CPP
Sbjct: 1246 CDPEVRP-LMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVR 1304
Query: 714 --YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQ 771
W G +G CS+SC GGL+ R V C + G + C A ++ P L+ C P
Sbjct: 1305 GNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQ-----SASYCDAASKPP--ELQQCGPG 1357
Query: 772 PCPARWEVSEPSSCTSAGGAGLALENETC-VPGADGLEAPVTEGPGSVDEKLPAPEPCVG 830
PCP +W C+ G G+ C P LE E + K P+ C
Sbjct: 1358 PCP-QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCE----IVNKPPSVIQCHM 1412
Query: 831 MSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMD 890
+CP A W WT SCS SCG+G C+D
Sbjct: 1413 HACP--------------ADVSWHQ--------EPWT----SCSASCGKGRKYREVFCID 1446
Query: 891 SALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAH 950
R +++ C KP + + C++V CP+ CSV+CG GV +R +YC
Sbjct: 1447 QFQR-KLEDTNCSQVQKPPTHK-ACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRL-- 1502
Query: 951 GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLG--PCSASCGLGTARRSVAC 1008
G +++ C RP Q C + C + K M G CS SC + + + C
Sbjct: 1503 ---KGVGQVVEEMCDQSTRPCSQRRCWSQDC-VQHKGMERGRLNCSTSCERKDSHQRMEC 1558
Query: 1009 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1068
Q +V+E + S C C Y +C+ +CG ++R C
Sbjct: 1559 T---DNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYC 1615
Query: 1069 LGPQAQAPVPADFCQHLPKPVTVRGC 1094
+ P H +P+ + C
Sbjct: 1616 ----TEIPSTKKHKLHRLRPIVYQEC 1637
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 374 bits (960), Expect = e-103
Identities = 278/978 (28%), Positives = 408/978 (41%), Gaps = 146/978 (14%)
Query: 71 RQRRAAGGI---LHLELLVAVGPDVFQAHQE-DTERYVLTNLNIGAELLRDPSLGAQFRV 126
R RR+AG L++E LV + + H + + Y+LT +N+ + L +D ++G+ V
Sbjct: 281 RPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINV 340
Query: 127 HLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDL-EL 185
+V +++L + G I + SL S C W + ++ HA L +T FD+
Sbjct: 341 VVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAIL---LTGFDICSW 397
Query: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
+ G + G CS SC I EDTG L TIAHE GH+FG+ HDG
Sbjct: 398 KNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAE 457
Query: 246 GHVMASDGAAPRAGLAWSPCSRRQLLSLLS-----------------------------A 276
G++M+ +WS CSR+ L LS A
Sbjct: 458 GNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDA 517
Query: 277 NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCS 336
+ QC+ FG KA C+ D+C++L CH C +P +GT CG+ WC
Sbjct: 518 DTQCKWQFGAKAKLCSLGFVK-DICKSLWCHRVG---HRCETKFMPAAEGTVCGLSMWCR 573
Query: 337 KGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 396
+G+C EL P +HG+WS+W S CSR+CGGGV + R CNNP+P +GG C G+
Sbjct: 574 QGQCVKFGELGP-RPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS 632
Query: 397 LQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMC 456
++CN C + L+F +QQCA + +P R FY W + D C+ C
Sbjct: 633 RIYQLCNINPCNENSLDFRAQQCAEYNSKPFR-----GWFYQWKPYTKVEEEDR-CKLYC 686
Query: 457 RAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQV 516
+A F DGT C P+ + D +C+ G C GCD + S+ V D C V
Sbjct: 687 KAENFEFFFAMSGKVKDGTPCSPN--KND----VCIDGVCELVGCDHELGSKAVSDACGV 740
Query: 517 CGGDNSTCSPRKGSF-TAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IGGRYVV 574
C GDNSTC KG + +A EY + + S+ I + ++LAVR + +Y +
Sbjct: 741 CKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYL 800
Query: 575 AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEY 634
G SI +P EY+ + R E + GP E ++ +
Sbjct: 801 TGGWSIDWPGEFP--FAGTTFEYQRSFN-----RPERLYAPGPTNETLVFEILMQG---- 849
Query: 635 GNLTRPDITFTYFQPK---------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARK 685
P I + Y PK R A+ W+ V+ CSVSCG G V CL
Sbjct: 850 ---KNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNT 906
Query: 686 ELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCV-----E 740
+ V + C +P P+ C CP YW G++ CS +C GG + R ++CV +
Sbjct: 907 Q-VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQ 965
Query: 741 AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 800
+ ++L +L P ++ CN CP +W + S C+ G G+ C
Sbjct: 966 KEEAVLHSLCPV-------STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLC 1018
Query: 801 VPGADGLEAPVTEGPGSVDEKLPAP---EPCVGMSCPPGWGHLDATSAGEKAPSPWGSIR 857
A P S LP P E CV CP S + S W
Sbjct: 1019 KGSA------AETLPESQCTSLPRPELQEGCVLGRCP-------KNSRLQWVASSW---- 1061
Query: 858 TGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR---VPVQEELCGLASKPG-SRRE 913
CS +CG G+ + C + + + E C KP E
Sbjct: 1062 -------------SECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEE 1108
Query: 914 VCQAVPCPARWQYKLAA---------CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQC 964
C CPA Y + A C+V+CG GV R ++C ++ + C
Sbjct: 1109 TCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--------QQGRPSSSC 1160
Query: 965 QGLPRPEPQEACSLEPCP 982
+P AC+ CP
Sbjct: 1161 LLHQKPPVLRACNTNFCP 1178
Score = 112 bits (280), Expect = 2e-24
Identities = 78/257 (30%), Positives = 115/257 (44%), Gaps = 37/257 (14%)
Query: 866 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEE------LCGLASKPGSRREVCQAV 918
W P S CS +C G + C+ + P Q+E LC +++ ++ + C +
Sbjct: 935 WMPGEWSTCSKACAGGQQSRKIQCVQ---KKPFQKEEAVLHSLCPVSTP--TQVQACNSH 989
Query: 919 PCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACS 977
CP +W + CS +CGRGV +R L C + E L ++QC LPRPE QE C
Sbjct: 990 ACPPQWSLGPWSQCSKTCGRGVRKRELLC-----KGSAAETLPESQCTSLPRPELQEGCV 1044
Query: 978 LEPCPP----RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEA 1032
L CP +W S CSA+CGLG +R + C + QG+ + E C + +P
Sbjct: 1045 LGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
Query: 1033 SV--PCLIADCTYR--------WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFC 1082
+ C C W+ W +C+V+CG G+Q R C+ Q P+ C
Sbjct: 1105 DLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSC 1160
Query: 1083 QHLPKPVTVRGCWAGPC 1099
KP +R C C
Sbjct: 1161 LLHQKPPVLRACNTNFC 1177
Score = 87.8 bits (216), Expect = 6e-17
Identities = 51/177 (28%), Positives = 73/177 (41%), Gaps = 7/177 (3%)
Query: 924 WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCP 982
W + CSVSCG G + C R D + + C +P + + C+ CP
Sbjct: 878 WSIVQSECSVSCGGGYINVKAICLR-----DQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
Query: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1042
W CS +C G R + CVQ Q E + + P C C
Sbjct: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
Query: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
+W +G W +CS +CG G+++R C G A+ +P C LP+P GC G C
Sbjct: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAET-LPESQCTSLPRPELQEGCVLGRC 1048
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 21/144 (14%)
Query: 652 RQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETV---QCQGSQQPPA-WPEACV 707
R WV A+ CS +CG G+R C ++ + + T +C+ ++P E C
Sbjct: 1053 RLQWV-ASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCN 1111
Query: 708 LEPCPPY--------WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ 759
CP + W + C+ +CGGG++ R V CV+ QG P + C +
Sbjct: 1112 RRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGR-----PSSSCLLHQK 1165
Query: 760 QPAVALETCNPQPCPARWEVSEPS 783
P L CN CPA + +PS
Sbjct: 1166 PPV--LRACNTNFCPAPEKREDPS 1187
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 367 bits (941), Expect = e-101
Identities = 303/1192 (25%), Positives = 456/1192 (38%), Gaps = 245/1192 (20%)
Query: 66 QRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFR 125
+R +R +R +E+LV + H E+ + Y+LT ++I A + +DPS+G
Sbjct: 279 KRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLIN 338
Query: 126 VHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPG--HADLVLYITRFDL 183
+ +V ++++ + P+I+ N ++L + C W + N PG H D + +TR D+
Sbjct: 339 IVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKN-----SPGGIHHDTAVLLTRQDI 393
Query: 184 ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCG 243
G+ +LG C P SC I+ED+G TIAHE+GH F + HD + C
Sbjct: 394 CRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDD--NNKCK 451
Query: 244 PSG-----HVMASDGAAPRAGLAWSPCSRRQLLSLL------------------------ 274
G HVMA WS CSR+ + L
Sbjct: 452 EEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLP 511
Query: 275 ----SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECG 330
+ N+QC + FGP + C + + C+ L C+ C P DGTEC
Sbjct: 512 GILYNVNKQCELIFGPGSQVCPYMMQ----CRRLWCNNVNGVHKGCRTQHTPWADGTECE 567
Query: 331 VEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGR 390
K C G C + + + G W SW P CSR+CGGG+ T R+CN P P GG+
Sbjct: 568 PGKHCKYGFC--VPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGK 625
Query: 391 ACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA 450
CVG ++ + CNT+ C K + +F +QCA DG+ + G W VP G
Sbjct: 626 YCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGIL 681
Query: 451 L---CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDS 507
+ C+ CR G + + D +DGT C T +CV G CR GCD ++S
Sbjct: 682 MKDRCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTNDICVQGLCRQAGCDHVLNS 735
Query: 508 QQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR 567
+ D+C VCGGDNS+C G+F Y T + + T++ + H +
Sbjct: 736 KARRDKCGVCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQH----SFSGET 790
Query: 568 IGGRYVV----AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDAD 623
Y+ G+ ++ N + R+ V +E I ++++
Sbjct: 791 DDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELL 850
Query: 624 IQVYRRYGEEYGNLTRPDITFTY---FQPKPRQAW-----VWAAVRGPC----------- 664
+QV G L PD+ +++ + KP+Q + W A PC
Sbjct: 851 LQVL-----SVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCT 905
Query: 665 ------------------------------------------SVSCGAGLRWVNYSCLDQ 682
S CG G R ++ C
Sbjct: 906 RESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKY 965
Query: 683 AR----KELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRC 738
+R E V+ C S P+ E C E W + CS SC GG + R C
Sbjct: 966 SRLDGKTEKVDDGFC-SSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAIC 1024
Query: 739 VEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENE 798
V + + L ++C Q V ++ C+ PCP +W+ + S C G G
Sbjct: 1025 VNTRNDV---LDDSKC---THQEKVTIQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQV 1077
Query: 799 TCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRT 858
C G D L + + P +P +C PW
Sbjct: 1078 WCQFGEDRLNDRMCD---------PETKPTSMQTC-------QQPECASWQAGPW----- 1116
Query: 859 GAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAV 918
G CSV+CG+G C+ V + C A++P ++ C+
Sbjct: 1117 ------------GQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQD-CELP 1163
Query: 919 PC---PA--------------RWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL 960
C PA +W++ CS +CG+G R + C D+ +
Sbjct: 1164 SCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC-----RDENGSVAD 1218
Query: 961 DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD 1020
++ C LPRP +E CS+ PC +WK + CS +CG G A R V CV D +D
Sbjct: 1219 ESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNY---SDHVID 1274
Query: 1021 EAACAALVRPEASVPCLIADCTYR---------------------------------WHV 1047
+ C PE C ++ C R W
Sbjct: 1275 RSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRT 1334
Query: 1048 GTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
G W CS +C G QRR C Q + A+ C KP R C +GPC
Sbjct: 1335 GPWGACSSTCAGGSQRRVVVC---QDENGYTANDCVERIKPDEQRACESGPC 1383
Score = 162 bits (409), Expect = 3e-39
Identities = 147/509 (28%), Positives = 206/509 (40%), Gaps = 64/509 (12%)
Query: 625 QVYRRYGEEYGN------LTRPDITFTYFQPKPR--QAWVWAAVRGPCSVSCGAGLRWVN 676
QV+ ++GE+ N T+P T QP+ QA W G CSV+CG G +
Sbjct: 1076 QVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPW----GQCSVTCGQGYQLRA 1131
Query: 677 YSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-----------------YWAVGD 719
C+ +V+ C + +P + C L C P W G
Sbjct: 1132 VKCIIGTYMSVVDDNDCNAATRPTDTQD-CELPSCHPPPAAPETRRSTYSAPRTQWRFGS 1190
Query: 720 FGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEV 779
+ PCSA+CG G R R V C + GS+ + C A +P VA E C+ PC +W+
Sbjct: 1191 WTPCSATCGKGTRMRYVSCRDENGSVADE---SAC-ATLPRP-VAKEECSVTPC-GQWKA 1244
Query: 780 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP---PG 836
+ SSC+ G G A CV +D + + D + C CP P
Sbjct: 1245 LDWSSCSVTCGQGRATRQVMCVNYSDHV---IDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
Query: 837 WGHLDATSAGEK-APSPWGSIRTGAQAAHVW-TPAAGSCSVSCGRGLMELRFLCMDSALR 894
G E P RT + W T G+CS +C G +C D
Sbjct: 1302 SGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDEN-- 1359
Query: 895 VPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGED 953
C KP +R C++ PCP +W Y C+ CG G+ R++ C R++GE
Sbjct: 1360 -GYTANDCVERIKPDEQR-ACESGPCP-QWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
Query: 954 DGEEILLDTQCQGLPRPEPQEACSLEPCP--PRWKVMSLGPCSASCGLGTARRSVACVQL 1011
D C+ L +P +E C+ CP W CS SCG G +R+V C+
Sbjct: 1417 -----FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAK 1471
Query: 1012 DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC-LG 1070
D G +E D C L +P C C +W G W +CSVSCG G+Q+R C +G
Sbjct: 1472 D-GSHLESDY--CKHLAKPHGHRKCRGGRCP-KWKAGAWSQCSVSCGRGVQQRHVGCQIG 1527
Query: 1071 PQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
A C +P + R C C
Sbjct: 1528 THKIARETE--CNPYTRPESERDCQGPRC 1554
Score = 156 bits (394), Expect = 1e-37
Identities = 128/450 (28%), Positives = 180/450 (40%), Gaps = 77/450 (17%)
Query: 662 GPCSVSCGAGLRWVNYSCLDQ---ARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG 718
G CS +C G + C D+ + VE ++ P AC PCP WA G
Sbjct: 1338 GACSSTCAGGSQRRVVVCQDENGYTANDCVERIK-------PDEQRACESGPCPQ-WAYG 1389
Query: 719 DFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP--AR 776
++G C+ CGGG+R R V C + G + P C + P E CN CP A
Sbjct: 1390 NWGECTKLCGGGIRTRLVVCQRSNG---ERFPDLSCEILDKPPD--REQCNTHACPHDAA 1444
Query: 777 WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG 836
W SSC+ + G G N C+ DG
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCM-AKDG------------------------------ 1473
Query: 837 WGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRV 895
HL++ A P G + W A S CSVSCGRG+ + C ++
Sbjct: 1474 -SHLESDYCKHLA-KPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKI 1531
Query: 896 PVQEELCGLASKPGSRREVCQAVPCPA------RWQYKLAACSVSCGRGVVRRILYCARA 949
+ E C ++P S R+ CQ CP WQ C+ +CG G R + C
Sbjct: 1532 ARETE-CNPYTRPESERD-CQGPRCPLYTWRAEEWQ----ECTKTCGEGSRYRKVVCV-- 1583
Query: 950 HGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACV 1009
DD + + +C RP +E+CSL+PC W CS +CG G +R V+C
Sbjct: 1584 ---DDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCS 1640
Query: 1010 QLDQGQ---DVEVDEAACAALVRPEASVPCLIADC--TYRWHVGTWMECSVSCGDGIQRR 1064
++ G+ + +P + PC + DC + W VG W CSVSCG G+ +R
Sbjct: 1641 EIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQR 1700
Query: 1065 RDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1094
CL + Q P+ C KP + C
Sbjct: 1701 SVQCLTNEDQ---PSHLCHTDLKPEERKTC 1727
Score = 72.4 bits (176), Expect = 3e-12
Identities = 72/259 (27%), Positives = 101/259 (38%), Gaps = 41/259 (15%)
Query: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPY-WAVGDFGP 722
CSVSCG G++ + C K ET +C +P + + C CP Y W ++
Sbjct: 1509 CSVSCGRGVQQRHVGCQIGTHKIARET-ECNPYTRPESERD-CQGPRCPLYTWRAEEWQE 1566
Query: 723 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 782
C+ +CG G R R V CV+ + + ARC + V E+C+ QPC W E
Sbjct: 1567 CTKTCGEGSRYRKVVCVDDNKN---EVHGARC--DVSKRPVDRESCSLQPCEYVWITGEW 1621
Query: 783 SSCTSAGGAGLALENETC---VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 839
S C+ G G +C G + E + P+ PC CP
Sbjct: 1622 SECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCP----- 1676
Query: 840 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 899
+ W R G W GSCSVSCG G+M+ C+ +
Sbjct: 1677 ---------VSATW---RVGN-----W----GSCSVSCGVGVMQRSVQCLTNE---DQPS 1712
Query: 900 ELCGLASKPGSRREVCQAV 918
LC KP R+ C+ V
Sbjct: 1713 HLCHTDLKP-EERKTCRNV 1730
Score = 32.0 bits (71), Expect = 4.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 6/55 (10%)
Query: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPR-PAFGGRACVGADL--QAEMCNTQAC 407
+ +WG C++ CGGG+ TR C F +C D E CNT AC
Sbjct: 1388 YGNWGE---CTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 358 bits (918), Expect = 2e-98
Identities = 277/964 (28%), Positives = 403/964 (41%), Gaps = 133/964 (13%)
Query: 80 LHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPE 138
L++E LV V + Q H E+ YVLT LN+ + L +D ++G + +V +++L + +
Sbjct: 290 LNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQ 349
Query: 139 GAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLV--LYITRFDLELPDGNRQVRGVT 196
I+ + +L S C W + +D T HA L+ L I + E D G
Sbjct: 350 PGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCD----TLGFA 405
Query: 197 QLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-GHVMASDGAA 255
+ G CS SC I EDTG L TIAHE GH+FG+ HDG G+ C S G++M+ A
Sbjct: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGE-GNMCKKSEGNIMSPTLAG 464
Query: 256 PRAGLAWSPCSRRQLLSLLS-----------------------------ANEQCRVAFGP 286
+WSPCSR+ L LS AN QC+ FG
Sbjct: 465 RNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGE 524
Query: 287 KAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVEL 346
KA C + D+C+AL CH C +P +GT CG + WC G+C +
Sbjct: 525 KAKLCMLDFKK-DICKALWCHRIG---RKCETKFMPAAEGTICGHDMWCRGGQCVKYGDE 580
Query: 347 TPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQA 406
P HG WS W SPCSR+CGGGV R R C NP+P+ GG+ C G+ ++CN+Q
Sbjct: 581 GP-KPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
Query: 407 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQ--GDALCRHMCRAIGESFI 464
C + ++F + QCA + + R Y W P++Q LC+ C A G F
Sbjct: 640 CPRDSVDFRAAQCAEHNSRRFR-----GRHYKW---KPYTQVEDQDLCKLYCIAEGFDFF 691
Query: 465 MKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 524
+ DGT C + + ++C+ G C GCD + S V D C VC G+NS C
Sbjct: 692 FSLSNKVKDGTPC------SEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSAC 745
Query: 525 SPRKGSFTA-GRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG-GRYVVAGKMSISP 582
+ +G +T +Y +T+ S+ I ++++VR RY + G ++
Sbjct: 746 TIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDW 805
Query: 583 NTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVY---RRYGEEYGNLTR 639
Y +YR + E E + GP E +++ R G + +
Sbjct: 806 PGRYK--FSGTTFDYRRSYNEP-----ENLIATGPTNETLIVELLFQGRNPGVAW-EYSM 857
Query: 640 PDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQP 699
P + T QP + ++ WA VR CSVSCG G V C + + V C +P
Sbjct: 858 PRLG-TEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQ-VNMSFCNPKTRP 915
Query: 700 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ 759
C + CPP W+VG++ CS +CGGG + RPV+C + +P + C
Sbjct: 916 VTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC----P 971
Query: 760 QPA-VALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSV 818
QPA + + CN Q CP W + C+ G G C A + P +V
Sbjct: 972 QPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLL--PDAV 1029
Query: 819 DEKLPAP---EPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSV 875
P P E C+ C + W W+ CSV
Sbjct: 1030 CTSEPKPRMHEACLLQRC------------HKPKKLQW--------LVSAWS----QCSV 1065
Query: 876 SCGRGLMELRFLCMDSALRVPVQE---ELCGLASKPGSRRE-VCQAVPCPARWQYKLAA- 930
+C RG + C + + +E + C KP E C +PCP + A
Sbjct: 1066 TCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGP 1125
Query: 931 ------------CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSL 978
C+ SCG GV R + C G C +P AC+
Sbjct: 1126 SRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASG--------CLLHQKPSASLACNT 1177
Query: 979 EPCP 982
CP
Sbjct: 1178 HFCP 1181
Score = 122 bits (305), Expect = 3e-27
Identities = 77/252 (30%), Positives = 110/252 (43%), Gaps = 17/252 (6%)
Query: 860 AQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVP 919
AQ ++ W CSVSCG G M +R C L+ V C ++P + C+
Sbjct: 868 AQPSYTWAIVRSECSVSCGGGQMTVREGCYRD-LKFQVNMSFCNPKTRPVTGLVPCKVSA 926
Query: 920 CPARWQY-KLAACSVSCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACS 977
CP W +ACS +CG G R + C R H + + L Q P P ++AC+
Sbjct: 927 CPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQ----PAPSSRQACN 982
Query: 978 LEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVE-VDEAACAALVRPEASVPC 1036
+ CPP W CS +CG G +R+VAC + + + +A C + +P C
Sbjct: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 1037 LIADC----TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA---PVPADFCQHLPKP- 1088
L+ C +W V W +CSV+C G Q+R C + + C HLPKP
Sbjct: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Query: 1089 -VTVRGCWAGPC 1099
R C PC
Sbjct: 1103 LELERACAPLPC 1114
Score = 92.0 bits (227), Expect = 3e-18
Identities = 79/293 (26%), Positives = 110/293 (37%), Gaps = 63/293 (21%)
Query: 827 PCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 886
PC +CPP W S G W+ +CS +CG G
Sbjct: 921 PCKVSACPPSW------SVGN------------------WS----ACSRTCGGGAQSRPV 952
Query: 887 LCM-----DSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVV 940
C DS PV LC + S R+ C + CP W A CS +CG+G
Sbjct: 953 QCTRRVHYDSE---PVPASLCPQPAP--SSRQACNSQSCPPAWSAGPWAECSHTCGKGWR 1007
Query: 941 RRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP----RWKVMSLGPCSAS 996
+R + C ++ ++L D C P+P EAC L+ C +W V + CS +
Sbjct: 1008 KRAVAC-KSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVT 1066
Query: 997 CGLGTARRSVACVQ-LDQGQDVEVDEAACAALVRPE-------ASVPC-------LIADC 1041
C GT +R + C + G+ E+ C+ L +P A +PC
Sbjct: 1067 CERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPS 1126
Query: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1094
W W +C+ SCG G+Q R CL PA C KP C
Sbjct: 1127 RGSWFASPWSQCTASCGGGVQTRSVQCLA----GGRPASGCLLHQKPSASLAC 1175
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 352 bits (903), Expect = 1e-96
Identities = 240/794 (30%), Positives = 351/794 (44%), Gaps = 86/794 (10%)
Query: 69 RQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVH 127
R RR+ +E LV + + H E+ E Y+LT +N+ L +PS+G +
Sbjct: 235 RSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIV 294
Query: 128 LVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
+V++++L E E I + +L S C W ++INP+ D +P H D+ + +TR D+
Sbjct: 295 VVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDI-CAG 353
Query: 188 GNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
NR + G++ L G C P SC I ED+G L TIAHE+GHSFG++HDG C P
Sbjct: 354 FNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKEND-CEPV 412
Query: 246 G---HVMASDGAAPRAGLAWSPCSRRQLLSLLS--------------------------- 275
G ++M+ L WS CS + L
Sbjct: 413 GRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIY 472
Query: 276 -ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 334
+ QC++ +GP A TF +E ++CQ L C + C L DGT+CG +KW
Sbjct: 473 DVHHQCQLQYGPNA---TFCQEVENVCQTLWCSV----KGFCRSKLDAAADGTQCGEKKW 525
Query: 335 CSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 394
C G+C ++ + ++ G W W P S CSR+CG GV + R CNNP P FGG+ C G
Sbjct: 526 CMAGKCITVGKKPE--SIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTG 583
Query: 395 ADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH 454
+ +CN C F QC+ D P ++ YHW P C
Sbjct: 584 ERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYKN-----ELYHW---FPIFNPAHPCEL 635
Query: 455 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 514
CR I F K D+ +DGT C G + ++C++G C+ GCD +DS DRC
Sbjct: 636 YCRPIDGQFSEKMLDAVIDGTPCFEGG----NSRNVCINGICKMVGCDYEIDSNATEDRC 691
Query: 515 QVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGG--RY 572
VC GD S+C + F YV + + + LA+R +Y
Sbjct: 692 GVCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKY 751
Query: 573 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE 632
+ G I N Y L +Y DR LE++ GP E IQ+ +
Sbjct: 752 YLNGGFIIQWNGNYK--LAGTVFQY------DRKGDLEKLMATGPTNESVWIQLLFQ--- 800
Query: 633 EYGNLTRPDITFTYFQPK-------PRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQAR 684
+T P I + Y K +Q + W CSV+CG G+R C+ + R
Sbjct: 801 ----VTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGR 856
Query: 685 KELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGLRERPVRCVEAQG 743
+V+ C QP + C + CPP W G++ CSA+CG G ++R V C++
Sbjct: 857 -GMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMV 915
Query: 744 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 803
S + LPP C+ +P L CP+ W V S C+ + G G+ + + TC
Sbjct: 916 SDEQALPPTDCQ-HLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN 974
Query: 804 ADGLEAPVTEGPGS 817
D VT P S
Sbjct: 975 HDE-PCDVTRKPNS 987
Score = 90.9 bits (224), Expect = 7e-18
Identities = 52/149 (34%), Positives = 74/149 (49%), Gaps = 9/149 (6%)
Query: 924 WQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 981
WQY CSV+CG G+ R+ +C + G ++ T C +P Q+ C + C
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKK-----GRGMVKATFCDPETQPNGRQKKCHEKAC 882
Query: 982 PPRWKVMSLGPCSASCGL-GTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC-LIA 1039
PPRW CSA+CG G +R+V C+Q + + C L++P+ + C
Sbjct: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
Query: 1040 DCTYRWHVGTWMECSVSCGDGIQRRRDTC 1068
C W VG W ECSVSCG G++ R TC
Sbjct: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTC 971
Score = 81.3 bits (199), Expect = 6e-15
Identities = 69/255 (27%), Positives = 95/255 (37%), Gaps = 32/255 (12%)
Query: 851 SPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGS 910
S + + G +AH CS +CG G R C + C +P
Sbjct: 1303 SNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQ------MDSDCAAIQRPDP 1356
Query: 911 RREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQ---G 966
+ C PC A W+ + CS +C G R + C + + L CQ G
Sbjct: 1357 AKR-CHLRPC-AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN----LRPFHCQFLAG 1410
Query: 967 LPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAA 1026
+P P +C+ EPC W+V CS SCG G R V C C
Sbjct: 1411 IPPPLSM-SCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVFC-----------PGGLCDW 1457
Query: 1027 LVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPAD--FCQH 1084
RP +++ C C + W G W CS SCG G Q+R C+ + D C H
Sbjct: 1458 TKRPTSTMSCNEHLCCH-WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDH 1516
Query: 1085 LPKPVTVRGCWAGPC 1099
P+P + C C
Sbjct: 1517 KPRPPEFKKCNQQAC 1531
Score = 79.3 bits (194), Expect = 2e-14
Identities = 54/179 (30%), Positives = 79/179 (44%), Gaps = 18/179 (10%)
Query: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQ 925
WT CSV+CG G+ C+ R V+ C ++P R++ C CP RW
Sbjct: 833 WT----ECSVTCGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 926 Y-KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEP-CP 982
+ ACS +CG G +R + C + D E+ L T CQ L +P+ +C+ + CP
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSD--EQALPPTDCQHLLKPKTLLSCNRDILCP 945
Query: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
W V + CS SCG G RSV C + + C +P + C + C
Sbjct: 946 SDWTVGNWSECSVSCGGGVRIRSVTC--------AKNHDEPCDVTRKPNSRALCGLQQC 996
Score = 79.0 bits (193), Expect = 3e-14
Identities = 47/141 (33%), Positives = 68/141 (48%), Gaps = 13/141 (9%)
Query: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQP-PAWPEACVLEPCPPYWAVGDFGP 722
CS +CG G W C Q + C Q+P PA + C L PC W VG++
Sbjct: 1325 CSTTCGLGAYWRRVECSTQMDSD------CAAIQRPDPA--KRCHLRPCAG-WKVGNWSK 1375
Query: 723 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 782
CS +C GG + R ++CV+++ + L P C+ A P +CNP+PC A W+V
Sbjct: 1376 CSRNCSGGFKIREIQCVDSRDH--RNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPW 1432
Query: 783 SSCTSAGGAGLALENETCVPG 803
S C+ + G G+ C G
Sbjct: 1433 SQCSRSCGGGVQERGVFCPGG 1453
Score = 64.3 bits (155), Expect = 7e-10
Identities = 69/273 (25%), Positives = 98/273 (35%), Gaps = 62/273 (22%)
Query: 714 YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC 773
+W VG++ CS +CG G R V C T + C A Q+P A + C+ +PC
Sbjct: 1316 HWIVGNWSECSTTCGLGAYWRRVEC--------STQMDSDC-AAIQRPDPA-KRCHLRPC 1365
Query: 774 PARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSC 833
A W+V S C+ G + CV D + L P + MSC
Sbjct: 1366 -AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFH-----CQFLAGIPPPLSMSC 1419
Query: 834 PPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSAL 893
P + A + PW CS SCG G+ E C
Sbjct: 1420 NP-----EPCEAWQ--VEPW-----------------SQCSRSCGGGVQERGVFCPGG-- 1453
Query: 894 RVPVQEELCGLASKPGSRREVCQAVPC---PARWQYKLAACSVSCGRGVVRRILYCARAH 950
LC +P S + + C W CS SCG G +R + C +
Sbjct: 1454 -------LCDWTKRPTSTMSCNEHLCCHWATGNWD----LCSTSCGGGFQKRTVQCVPSE 1502
Query: 951 GE--DDGEEILLDTQCQGLPRPEPQEACSLEPC 981
G +D ++ L C PRP + C+ + C
Sbjct: 1503 GNKTEDQDQCL----CDHKPRPPEFKKCNQQAC 1531
Score = 55.5 bits (132), Expect = 3e-07
Identities = 39/128 (30%), Positives = 60/128 (46%), Gaps = 20/128 (15%)
Query: 649 PKPRQAWV---WAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEA 705
P+P +AW W+ CS SCG G+ Q R C +++P + +
Sbjct: 1421 PEPCEAWQVEPWSQ----CSRSCGGGV---------QERGVFCPGGLCDWTKRPTS-TMS 1466
Query: 706 CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 765
C C +WA G++ CS SCGGG ++R V+CV ++G+ KT +C +
Sbjct: 1467 CNEHLCC-HWATGNWDLCSTSCGGGFQKRTVQCVPSEGN--KTEDQDQCLCDHKPRPPEF 1523
Query: 766 ETCNPQPC 773
+ CN Q C
Sbjct: 1524 KKCNQQAC 1531
Score = 52.8 bits (125), Expect = 2e-06
Identities = 47/218 (21%), Positives = 78/218 (35%), Gaps = 48/218 (22%)
Query: 777 WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG 836
W+ + C+ G G+ + C+ G+ P + + + C +CPP
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPET--QPNGRQKKCHEKACPPR 885
Query: 837 WGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCG-RGLMELRFLCMDSALR- 894
W W +CS +CG G + LC+ + +
Sbjct: 886 W----------------------------WAGEWEACSATCGPHGEKKRTVLCIQTMVSD 917
Query: 895 ---VPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAH 950
+P + C KP + + + CP+ W + CSVSCG GV R + CA+ H
Sbjct: 918 EQALPPTD--CQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH 975
Query: 951 GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 988
D C +P + C L+ CP +V+
Sbjct: 976 ----------DEPCDVTRKPNSRALCGLQQCPSSRRVL 1003
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/46 (41%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1088
Y W G W ECSV+CG GI+R+ C+ + + V A FC +P
Sbjct: 826 YFWQYGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQP 870
Score = 41.6 bits (96), Expect = 0.005
Identities = 50/169 (29%), Positives = 66/169 (39%), Gaps = 19/169 (11%)
Query: 340 CRSLVELTPIAAVHGR-WSSW--GPRSPCSRSCGGGVVTRRRQC------NNPRPAFGGR 390
C ++ P H R + W G S CSR+C GG R QC N RP F +
Sbjct: 1348 CAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRP-FHCQ 1406
Query: 391 ACVGADLQAEM-CNTQACEKTQLEFMSQQCARTDGQPLRS----SPGGASFYHWGAAVPH 445
G M CN + CE Q+E S QC+R+ G ++ PGG +
Sbjct: 1407 FLAGIPPPLSMSCNPEPCEAWQVEPWS-QCSRSCGGGVQERGVFCPGGLCDWTKRPTSTM 1465
Query: 446 SQGDALCRHMCRAIGESFIMKRGDSFLDGT-RCMPS--GPREDGTLSLC 491
S + LC H + G F T +C+PS ED LC
Sbjct: 1466 SCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLC 1514
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 330 bits (846), Expect = 6e-90
Identities = 261/830 (31%), Positives = 356/830 (42%), Gaps = 102/830 (12%)
Query: 68 QRQRQRRAAGGILH---------LELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRD 117
QRQ+ RR LH +E LV + + H Q E YVLT +N+ A L D
Sbjct: 221 QRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLFHD 280
Query: 118 PSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLY 177
PS+G + +V++V+L + E IT + ++L S C W ++IN + D P H D +
Sbjct: 281 PSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTAIL 340
Query: 178 ITRFDLELPDGNR--QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHD 235
+TR DL NR + G++ + G C P SC I EDTG L T+AHE+GHSFG++HD
Sbjct: 341 LTRKDL-CAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQHD 399
Query: 236 GAPGSGCGPSGH---VMASDGAAPRAGLAWSPCSRRQLLSLLS----------------- 275
G+ G+ C P G +M+ A L WS CSR+ + L
Sbjct: 400 GS-GNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDIID 458
Query: 276 -----------ANEQCRVAFGPKAVACTFAREHLD-MCQALSCHTDPLDQSSCSRLLVPL 323
+ QCR+ +G + C E +D +C L C ++C L
Sbjct: 459 FPSVPPGVLYDVSHQCRLQYGAYSAFC----EDMDNVCHTLWCSVG----TTCHSKLDAA 510
Query: 324 LDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 383
+DGT CG KWC G C V P AV G WS W S CSRSCG GV + RQC P
Sbjct: 511 VDGTRCGENKWCLSGECVP-VGFRP-EAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQP 568
Query: 384 RPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAV 443
P + GR CVG + +CN QAC + F QC+ D + + W V
Sbjct: 569 TPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYK-----GQLHTW---V 620
Query: 444 PHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDG 503
P C CR E F K D+ +DGT C D LC++G C+ GCD
Sbjct: 621 PVVNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRD----LCINGICKNVGCDF 676
Query: 504 RMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTH 563
+DS + DRC VC G+ STC G+F YV + + I
Sbjct: 677 EIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQEVAEAANF 736
Query: 564 LAVRIGG--RYVVAGKMSISPNTTYPSLLEDGRVEYRVA---LTEDRLPRLEEIRIWGPL 618
LA+R +Y + G +I N +Y+VA T R E + GP
Sbjct: 737 LALRSEDPEKYFLNGGWTIQWNG-----------DYQVAGTTFTYARRGNWENLTSPGPT 785
Query: 619 QEDADIQVY---RRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGP---CSVSCGAGL 672
+E IQ+ G Y + P P +W + GP C+V+CG G+
Sbjct: 786 KEPVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHY----GPWTKCTVTCGRGV 841
Query: 673 RWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG-GGL 731
+ N CL++ + V+ C +P C +PCP W G++ CS+SCG GGL
Sbjct: 842 QRQNVYCLER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGL 900
Query: 732 RERPVRCVEAQG-SLLKTLPPARCRAGAQQPAVALETCNPQ-PCPARWEVSEPSSCTSAG 789
R V C+ + G L P C + P CN PCPA W V S C+
Sbjct: 901 SRRAVLCIRSVGLDEQSALEPPACEHLPRPPTET--PCNRHVPCPATWAVGNWSQCSVTC 958
Query: 790 GAGLALENETCVPGADGLEAPVTEGPGS-VDEKLPAPEPCVGMSCPPGWG 838
G G N C G+ + P S V LP +G P G G
Sbjct: 959 GEGTQRRNVLCT-NDTGVPCDEAQQPASEVTCSLPLCRWPLGTLGPEGSG 1007
Score = 110 bits (274), Expect = 1e-23
Identities = 82/232 (35%), Positives = 112/232 (48%), Gaps = 26/232 (11%)
Query: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW- 924
WT C+V+CGRG+ C++ PV EE C +P ++ C PCPARW
Sbjct: 830 WT----KCTVTCGRGVQRQNVYCLERQAG-PVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
Query: 925 --QYKLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE-P 980
+++L CS SCG G+ RR + C R+ G D+ + L C+ LPRP + C+ P
Sbjct: 885 AGEWQL--CSSSCGPGGLSRRAVLCIRSVGLDE-QSALEPPACEHLPRPPTETPCNRHVP 941
Query: 981 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1040
CP W V + CS +CG GT RR+V C D G V DEA +P + V C +
Sbjct: 942 CPATWAVGNWSQCSVTCGEGTQRRNVLCTN-DTG--VPCDEAQ-----QPASEVTCSLPL 993
Query: 1041 CTYRWHVGT-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTV 1091
C RW +GT E S S + + P AP P+ PKP T+
Sbjct: 994 C--RWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAPRPSPASS--PKPGTM 1041
Score = 106 bits (265), Expect = 1e-22
Identities = 77/211 (36%), Positives = 95/211 (45%), Gaps = 26/211 (12%)
Query: 896 PVQEELCGLASKPGSRREVC--------QAVPCPA-RWQY-KLAACSVSCGRGVVRRILY 945
PV +L S PG E VP P W Y C+V+CGRGV R+ +Y
Sbjct: 788 PVWIQLLFQESNPGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVY 847
Query: 946 CARAHGEDDGEEILLDTQCQGLPRPEPQEA-CSLEPCPPRWKVMSLGPCSASCGLG-TAR 1003
C EE C L RP+ Q+ CS +PCP RW CS+SCG G +R
Sbjct: 848 CLERQAGPVDEE-----HCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSR 902
Query: 1004 RSVACVQ---LDQGQDVEVDEAACAALVRPEASVPC-LIADCTYRWHVGTWMECSVSCGD 1059
R+V C++ LD+ +E AC L RP PC C W VG W +CSV+CG+
Sbjct: 903 RAVLCIRSVGLDEQSALE--PPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGE 960
Query: 1060 GIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1090
G QRR C VP D Q VT
Sbjct: 961 GTQRRNVLCTN---DTGVPCDEAQQPASEVT 988
Score = 94.4 bits (233), Expect = 7e-19
Identities = 77/261 (29%), Positives = 101/261 (38%), Gaps = 35/261 (13%)
Query: 856 IRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVC 915
+R A W+ CS +CG G + C ++E C A +P R C
Sbjct: 1410 VRNAGWQAGNWS----ECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARR-C 1458
Query: 916 QAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEI--LLDTQCQ-GLPRPEP 972
PC + CS SCG G R + C D ++ L CQ G +P
Sbjct: 1459 HLRPCATWHSGNWSKCSRSCGGGSSVRDVQCV------DTRDLRPLRPFHCQPGPAKPPA 1512
Query: 973 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1032
C +PC W S CS +CG G +R V C + C +RP
Sbjct: 1513 HRPCGAQPCLS-WYTSSWRECSEACGGGEQQRLVTCPE----------PGLCEEALRPNT 1561
Query: 1033 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAP-VPADFCQHLPKPVTV 1091
+ PC CT +W VG W +CS CG G+QRR C+ Q P +D C H P +
Sbjct: 1562 TRPCNTHPCT-QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS 1620
Query: 1092 RGCWAGPC--VGQGACGRQHL 1110
R C C V C R L
Sbjct: 1621 RPCGTEDCEPVEPPRCERDRL 1641
Score = 75.5 bits (184), Expect = 3e-13
Identities = 72/265 (27%), Positives = 96/265 (36%), Gaps = 60/265 (22%)
Query: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPC 723
CS +CG G W C ++ G QP C L PC W G++ C
Sbjct: 1423 CSTTCGLGAVWRPVRCSSGRDEDCAPA----GRPQPA---RRCHLRPCAT-WHSGNWSKC 1474
Query: 724 SASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPS 783
S SCGGG R V+CV+ + L+ L P C+ G +P A C QPC W S
Sbjct: 1475 SRSCGGGSSVRDVQCVDTRD--LRPLRPFHCQPGPAKPP-AHRPCGAQPC-LSWYTSSWR 1530
Query: 784 SCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMSCPPGWGHLD 841
C+ A G G TC PG +E L PC C
Sbjct: 1531 ECSEACGGGEQQRLVTC------------PEPGLCEEALRPNTTRPCNTHPCT------- 1571
Query: 842 ATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE-E 900
+ PW G CS CG G+ C+++ +P ++ +
Sbjct: 1572 -----QWVVGPW-----------------GQCSGPCGGGVQRRLVKCVNTQTGLPEEDSD 1609
Query: 901 LCGLASKPGSRR----EVCQAVPCP 921
CG + P S R E C+ V P
Sbjct: 1610 QCGHEAWPESSRPCGTEDCEPVEPP 1634
Score = 70.1 bits (170), Expect = 1e-11
Identities = 49/143 (34%), Positives = 64/143 (44%), Gaps = 12/143 (8%)
Query: 973 QEACSLEPCPPRWKVMSLGP---CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVR 1029
+EA + PP GP C+ +CG G R++V C++ G VDE C L R
Sbjct: 810 REAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP---VDEEHCDPLGR 866
Query: 1030 PEASV-PCLIADCTYRWHVGTWMECSVSCGDG-IQRRRDTCL---GPQAQAPVPADFCQH 1084
P+ C C RW G W CS SCG G + RR C+ G Q+ + C+H
Sbjct: 867 PDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEH 926
Query: 1085 LPKPVTVRGCWAG-PCVGQGACG 1106
LP+P T C PC A G
Sbjct: 927 LPRPPTETPCNRHVPCPATWAVG 949
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/69 (37%), Positives = 35/69 (50%), Gaps = 2/69 (2%)
Query: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP-VTVRGCWAGPCVG 1101
+ WH G W +C+V+CG G+QR+ CL QA PV + C L +P R C PC
Sbjct: 823 FSWHYGPWTKCTVTCGRGVQRQNVYCLERQA-GPVDEEHCDPLGRPDDQQRKCSEQPCPA 881
Query: 1102 QGACGRQHL 1110
+ G L
Sbjct: 882 RWWAGEWQL 890
Score = 48.9 bits (115), Expect = 3e-05
Identities = 31/96 (32%), Positives = 45/96 (46%), Gaps = 11/96 (11%)
Query: 650 KPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLE 709
+P +W ++ R CS +CG G + +C E C+ + +P C
Sbjct: 1519 QPCLSWYTSSWR-ECSEACGGGEQQRLVTC--------PEPGLCEEALRPNT-TRPCNTH 1568
Query: 710 PCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSL 745
PC W VG +G CS CGGG++ R V+CV Q L
Sbjct: 1569 PCTQ-WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGL 1603
Score = 33.1 bits (74), Expect = 1.8
Identities = 28/70 (40%), Positives = 30/70 (42%), Gaps = 13/70 (18%)
Query: 327 TECGVEK-W----CSKGR---CRSLVELTPIAAVHGR----WSSWGPRSPCSRSCGGGVV 374
T CG+ W CS GR C P H R W S G S CSRSCGGG
Sbjct: 1425 TTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS-GNWSKCSRSCGGGSS 1483
Query: 375 TRRRQCNNPR 384
R QC + R
Sbjct: 1484 VRDVQCVDTR 1493
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 325 bits (832), Expect = 2e-88
Identities = 256/882 (29%), Positives = 363/882 (41%), Gaps = 120/882 (13%)
Query: 63 PGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLG 121
PG +R R+R ++E LV + H + D E+YVL +NI A+L +D SLG
Sbjct: 229 PGLKRSVSRER-------YVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLG 281
Query: 122 AQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADL 174
+ + + ++++LTE + IT + SL S C W ++I N + + D
Sbjct: 282 STVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDT 341
Query: 175 VLYITRFDLEL----PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSF 230
+ ITR+D+ + P G G+ +GG C SC + ED G TIAHEIGH+F
Sbjct: 342 AVLITRYDICIYKNKPCGTL---GLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTF 398
Query: 231 GLEHDGAPGSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLL------------ 274
G+ HDG G+ CG G +MA+ WS CSR + S L
Sbjct: 399 GMNHDGV-GNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRP 457
Query: 275 ----------------SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSR 318
A+EQCR G K+ C + ++C L C + + C
Sbjct: 458 PRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYG----EVCSELWCLS---KSNRCIT 510
Query: 319 LLVPLLDGTECGV----EKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVV 374
+P +GT C + WC K C V G W W P CSR+CGGGV
Sbjct: 511 NSIPAAEGTLCQTHTIDKGWCYKRVCVPFGSRP--EGVDGAWGPWTPWGDCSRTCGGGVS 568
Query: 375 TRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGA 434
+ R C++PRP GG+ C+G + CNT C +F QC+ D P R
Sbjct: 569 SSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFR-----G 623
Query: 435 SFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSG 494
FY W G C C A G +F +R + +DGT C P T+ +CVSG
Sbjct: 624 KFYKW--KTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPD------TVDICVSG 675
Query: 495 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVY 553
C+ GCD + S D+C+VCGGD S C +G F+ A Y + + ++
Sbjct: 676 ECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIF 735
Query: 554 IANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIR 613
I + +HLA++ ++ + P T P L +++ D++ LE +
Sbjct: 736 IQDLNLSLSHLALKGDQESLLLEGL---PGTPQPHRLPLAGTTFQLRQGPDQVQSLEAL- 791
Query: 614 IWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP-----KPRQAWVWAAVRGPCSVSC 668
GP+ + V R P + + + P P +W +A CS C
Sbjct: 792 --GPINASLIVMVLAR-------TELPALRYRFNAPIARDSLPPYSWHYAPWT-KCSAQC 841
Query: 669 GAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG 728
G + C +Q V C + P AC EPCPP W VG++ CS SC
Sbjct: 842 AGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWVVGNWSLCSRSCD 901
Query: 729 GGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTS 787
G+R R V C + K L + C Q LE C+ CP W + S CT
Sbjct: 902 AGVRSRSVVCQRRVSAAEEKALDDSAC---PQPRPPVLEACHGPTCPPEWAALDWSECTP 958
Query: 788 AGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG------WGHLD 841
+ G GL C AD A + S K PA C CPP WG
Sbjct: 959 SCGPGLRHRVVLC-KSADH-RATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECS 1016
Query: 842 A-TSAGEKAPSPWGSIRTGAQAAHVWT-----PAAGSCSVSC 877
A G++ S + TG QA+H T P C C
Sbjct: 1017 AQCGVGQRQRSVRCTSHTG-QASHECTEALRPPTTQQCEAKC 1057
Score = 112 bits (280), Expect = 2e-24
Identities = 77/243 (31%), Positives = 94/243 (38%), Gaps = 16/243 (6%)
Query: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQ 925
WT CS C G C + V C SK R+ C PCP W
Sbjct: 834 WT----KCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDWV 889
Query: 926 Y-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 984
+ CS SC GV R + C R EE LD PRP EAC CPP
Sbjct: 890 VGNWSLCSRSCDAGVRSRSVVCQRRVSA--AEEKALDDSACPQPRPPVLEACHGPTCPPE 947
Query: 985 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT-Y 1043
W + C+ SCG G R V C D + A C+ +P A++ C + C
Sbjct: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHR--ATLPPAHCSPAAKPPATMRCNLRRCPPA 1005
Query: 1044 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWA---GPCV 1100
RW G W ECS CG G ++R C QA + C +P T + C A P
Sbjct: 1006 RWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---SHECTEALRPPTTQQCEAKCDSPTP 1062
Query: 1101 GQG 1103
G G
Sbjct: 1063 GDG 1065
Score = 85.1 bits (209), Expect = 4e-16
Identities = 52/176 (29%), Positives = 71/176 (40%), Gaps = 6/176 (3%)
Query: 921 PARWQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 979
P W Y CS C G + + C + D + P+ Q AC+ E
Sbjct: 826 PYSWHYAPWTKCSAQCAGGSQVQAVEC---RNQLDSSAVAPHYCSAHSKLPKRQRACNTE 882
Query: 980 PCPPRWKVMSLGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLI 1038
PCPP W V + CS SC G RSV C ++ ++ +D++AC RP C
Sbjct: 883 PCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEACHG 941
Query: 1039 ADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1094
C W W EC+ SCG G++ R C +A +P C KP C
Sbjct: 942 PTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRC 997
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 321 bits (823), Expect = 3e-87
Identities = 245/841 (29%), Positives = 359/841 (42%), Gaps = 118/841 (14%)
Query: 71 RQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHLV 129
RQ+R+ +E LV + H ++D E Y+L+ +NI A+L RD SLG + +
Sbjct: 241 RQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVA 300
Query: 130 KMVILTEPEGAPNITANLTSSLLSVCGWSQTI-------NPEDDTDPGHADLVLYITRFD 182
++++LTE + I + SL S C W ++I N + H D + ITR+D
Sbjct: 301 RLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYD 360
Query: 183 L----ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAP 238
+ P G G+ + G C P SC I ED G TIAHEIGH+FG+ HDG
Sbjct: 361 ICTYKNKPCGTL---GLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGI- 416
Query: 239 GSGCGPSGH----VMASDGAAPRAGLAWSPCSRRQLLSLLS------------------- 275
G+ CG GH +MA+ A +WS CSR + S L
Sbjct: 417 GNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYP 476
Query: 276 ---------ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDG 326
A+EQCR +G + C + ++C+ L C + + C +P +G
Sbjct: 477 AVAPGQVYDADEQCRFQYGATSRQCKYG----EVCRELWCLSK---SNRCVTNSIPAAEG 529
Query: 327 TEC---GVEK-WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNN 382
T C +EK WC +G C T ++ G W W CSR+CGGGV + R C++
Sbjct: 530 TLCQTGNIEKGWCYQGDCVPFG--TWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDS 587
Query: 383 PRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAA 442
P P+ GG+ C+G + CNT C +F +QCA D P R +Y+W
Sbjct: 588 PAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFR-----GKYYNW--- 639
Query: 443 VPHSQGDAL-CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGC 501
P++ G C C A G +F +R + +DGT+C +L +C++G C+ GC
Sbjct: 640 KPYTGGGVKPCALNCLAEGYNFYTERAPAVIDGTQC------NADSLDICINGECKHVGC 693
Query: 502 DGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAR-EYVTFLTVTPNLTSVYIANHRPL 560
D + S DRC+VCGGD STC +G F R Y+ + + + +
Sbjct: 694 DNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMS 753
Query: 561 FTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQ 619
++A++ G Y + G +I +P + + D LE + GP
Sbjct: 754 KNYIALKSEGDDYYINGAWTID----WPRKFDVAGTAFHYKRPTDEPESLEAL---GPTS 806
Query: 620 EDADIQVY---RRYGEEYG---NLTRP-----DITFTYFQPKPRQAWVWAAVRGPCSVSC 668
E+ + V + G Y +TR ++ FT+ Q W CS +C
Sbjct: 807 ENLIVMVLLQEQNLGIRYKFNVPITRTGSGDNEVGFTW----NHQPW------SECSATC 856
Query: 669 GAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCG 728
G++ C +V+ C +PP AC EPCPP W +GD+ CS +C
Sbjct: 857 AGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCD 916
Query: 729 GGLRERPVRCVEAQG-SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTS 787
GG+R R V C+ G S +TL + C V E CN Q CP +W + S CT
Sbjct: 917 GGMRTRAVLCIRKIGPSEEETLDYSGC---LTHRPVEKEPCNNQSCPPQWVALDWSECTP 973
Query: 788 AGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPP------GWGHLD 841
G G C P + P + K P C CPP WG
Sbjct: 974 KCGPGFKHRIVLCKSSDLSKTFPAAQCP--EESKPPVRIRCSLGRCPPPRWVTGDWGQCS 1031
Query: 842 A 842
A
Sbjct: 1032 A 1032
Score = 106 bits (265), Expect = 1e-22
Identities = 72/244 (29%), Positives = 97/244 (39%), Gaps = 13/244 (5%)
Query: 857 RTGA---QAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRR 912
RTG+ + W S CS +C G+ +C VQ C SKP +
Sbjct: 832 RTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQ 891
Query: 913 EVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 971
C PCP W CS +C G+ R + C R G EE LD RP
Sbjct: 892 RACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIG--PSEEETLDYSGCLTHRPV 949
Query: 972 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
+E C+ + CPP+W + C+ CG G R V C D + A C +P
Sbjct: 950 EKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPA--AQCPEESKPP 1007
Query: 1032 ASVPCLIADC-TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVT 1090
+ C + C RW G W +CS CG G Q R CL QA + C +P +
Sbjct: 1008 VRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA---SSDCLETVRPPS 1064
Query: 1091 VRGC 1094
++ C
Sbjct: 1065 MQQC 1068
Score = 92.4 bits (228), Expect = 3e-18
Identities = 62/219 (28%), Positives = 87/219 (39%), Gaps = 23/219 (10%)
Query: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRP-EPQEACSLEPCPPRWKVMS 989
CS +C GV R+ + C R D I+ + C +P E Q AC+ EPCPP W +
Sbjct: 852 CSATCAGGVQRQEVVCKRL----DDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGD 907
Query: 990 LGPCSASCGLGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
CS +C G R+V C+ ++ ++ +D + C RP PC C +W
Sbjct: 908 WLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLT-HRPVEKEPCNNQSCPPQWVAL 966
Query: 1049 TWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQ--------------HLPKPVTVRGC 1094
W EC+ CG G + R C PA C P P V G
Sbjct: 967 DWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGD 1026
Query: 1095 WAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAIGRP 1133
W G C Q G+Q + + G +DC + P
Sbjct: 1027 W-GQCSAQCGLGQQ-MRTVQCLSYTGQASSDCLETVRPP 1063
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/101 (32%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 657 WAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-Y 714
W A+ C+ CG G + C + QC +PP C L CPP
Sbjct: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIR-CSLGRCPPPR 1021
Query: 715 WAVGDFGPCSASCGGGLRERPVRCV----EAQGSLLKTLPP 751
W GD+G CSA CG G + R V+C+ +A L+T+ P
Sbjct: 1022 WVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRP 1062
Score = 38.1 bits (87), Expect = 0.057
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 1/58 (1%)
Query: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK-PVTVRGCWAGPC 1099
+ W+ W ECS +C G+QR+ C + V ++C K P R C PC
Sbjct: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC 899
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 320 bits (821), Expect = 4e-87
Identities = 282/946 (29%), Positives = 383/946 (40%), Gaps = 169/946 (17%)
Query: 59 RPPSPGFQRQRQRQRRAAGGILH---LELLVAVGPDVFQAH-QEDTERYVLTNLNIGAEL 114
+ P+ G + R+RR A + +E LV D+ Q H E +R++LT +N+ +
Sbjct: 208 KKPTWGRPSRDWRERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNM 267
Query: 115 LRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTIN-----------P 163
+ SLG + + + K+V+L + +I + SL S C W P
Sbjct: 268 FQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVP 327
Query: 164 EDDTDPGHADLVLYITRFDLEL-PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTI 222
DP D +++TR D + D G+ LGG CS C++ ED G +L TI
Sbjct: 328 GGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTI 387
Query: 223 AHEIGHSFGLEHDGAPGSGCGPSGHVMASDGAAPR--AGLAWSPCSRRQLLSLL------ 274
AHE+GH+ G+ HD S C H+M+ + R + L+WS CSR L + L
Sbjct: 388 AHELGHNLGMNHDD-DHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVST 446
Query: 275 ------------------------SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDP 310
SANEQC++ FG A C EHL MC L C +
Sbjct: 447 CLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHL-MCAGLWCLVE- 503
Query: 311 LDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAA-VHGRWSSWGPRSPCSRSC 369
+SC L P LDGTECG +KWC G C V TPI V G WS WG S CSR+C
Sbjct: 504 -GDTSCKTKLDPPLDGTECGADKWCRAGEC---VSKTPIPEHVDGDWSPWGAWSMCSRTC 559
Query: 370 GGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRS 429
G G R+R+C+NP P GG C GA ++ +C C K F QQC D R
Sbjct: 560 GTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD----RL 615
Query: 430 SPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLS 489
SP G D C C +G+ + D LDGT C GP E
Sbjct: 616 SPKKK-----GLLTAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPC---GPYE---TD 664
Query: 490 LCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNL 549
LCV G C+ GCDG + S DRC VC GD TC KG F+ R
Sbjct: 665 LCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDFSHARG------------- 711
Query: 550 TSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRL 609
T++ + + + + + G + +AG TT V Y R
Sbjct: 712 TALKDSGKGSINSDWKIELPGEFQIAG-------TT---------VRY------VRRGLW 749
Query: 610 EEIRIWGPLQEDADIQVYRRYGEEYG---NLTRPDITFTYFQPKPRQ------AWVWAAV 660
E+I GP + + V + ++YG T P Q +P + W +
Sbjct: 750 EKISAKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIWTHSGW 809
Query: 661 RGPCSVSCGAGLRWVNYSCLDQARK--ELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG 718
G CSV CG G R SC K LV C + +P C L PC W G
Sbjct: 810 EG-CSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAG 868
Query: 719 DFGPCSASCGGGLRERPVRCV-EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARW 777
+ PCSA+C G + R V CV + Q P C +PA A+++C Q C + W
Sbjct: 869 PWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC--PGPRPA-AVQSCEGQDCLSIW 925
Query: 778 EVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGW 837
E SE S C+++ G G+ C ++G + A E C S W
Sbjct: 926 EASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDYSGCYEW 976
Query: 838 GHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPV 897
+TG W+ +CS +CG+GL CM
Sbjct: 977 -------------------KTGD-----WS----TCSSTCGKGLQSRVVQCMHKVTGRHG 1008
Query: 898 QEELCGLASKPGSRREVCQAVPCPAR------WQYKLAACSVSCGR 937
E C SKP R+ Q V C R +LAA + C R
Sbjct: 1009 SE--CPALSKPAPYRQCYQEV-CNDRINANTITSPRLAALTYKCTR 1051
Score = 101 bits (251), Expect = 5e-21
Identities = 70/240 (29%), Positives = 95/240 (39%), Gaps = 19/240 (7%)
Query: 865 VWTPAAGS-CSVSCGRGLMELRFLCMDSALRVP--VQEELCGLASKPGSRREVCQAVPCP 921
+WT + CSV CG G C + V + C AS+P + C PC
Sbjct: 803 IWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
Query: 922 ARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQCQGLPRPEPQEACSLE 979
+RW + CS +C +G R + C + +G + C G PRP ++C +
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCV--YQLQNGTHVATRPLYCPG-PRPAAVQSCEGQ 919
Query: 980 PCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIA 1039
C W+ CSASCG G +R+VAC + C A RP A C
Sbjct: 920 DCLSIWEASEWSQCSASCGKGVWKRTVACTN---------SQGKCDASTRPRAEEACEDY 970
Query: 1040 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Y W G W CS +CG G+Q R C+ C L KP R C+ C
Sbjct: 971 SGCYEWKTGDWSTCSSTCGKGLQSRVVQCM--HKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 77.4 bits (189), Expect = 9e-14
Identities = 67/273 (24%), Positives = 96/273 (35%), Gaps = 48/273 (17%)
Query: 715 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
W + CS CGGG R V C + + C A +P + CN PC
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQ-ASRPEPQVRRCNLHPCQ 862
Query: 775 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKL--PAPEPCVGMS 832
+RW S C++ G TCV + G L P P P S
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCV-------YQLQNGTHVATRPLYCPGPRPAAVQS 915
Query: 833 CPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA 892
C G+ S W A W+ CS SCG+G+ + C +S
Sbjct: 916 C-----------EGQDCLSIW--------EASEWS----QCSASCGKGVWKRTVACTNS- 951
Query: 893 LRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHG 951
+ C +++P + E C+ W+ + CS +CG+G+ R++ C
Sbjct: 952 ------QGKCDASTRPRA-EEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVT 1004
Query: 952 EDDGEEILLDTQCQGLPRPEPQEACSLEPCPPR 984
G E C L +P P C E C R
Sbjct: 1005 GRHGSE------CPALSKPAPYRQCYQEVCNDR 1031
Score = 30.8 bits (68), Expect = 9.1
Identities = 28/90 (31%), Positives = 33/90 (36%), Gaps = 17/90 (18%)
Query: 1040 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLG--------------PQAQAPVP-ADFCQ- 1083
D + W W CSV CG G +R +C PQA P P C
Sbjct: 799 DSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNL 858
Query: 1084 HLPKPVTVRGCWAGPCVGQGACGRQHLEPT 1113
H + V G W+ PC G QH E T
Sbjct: 859 HPCQSRWVAGPWS-PCSATCEKGFQHREVT 887
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 317 bits (812), Expect = 5e-86
Identities = 244/789 (30%), Positives = 348/789 (44%), Gaps = 112/789 (14%)
Query: 68 QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126
+R+ +R AA ++E+L+ V V Q H +E ++Y+LT +NI E+ D SLGA V
Sbjct: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
Query: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
LV++++L+ + I N + SL +VC W+ D + D +++TR D
Sbjct: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
Query: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDE 428
Query: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SA 276
G +MA A WS CS+++L L S
Sbjct: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSM 488
Query: 277 NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCS 336
NEQCR FG + CT R D C+ L C + P + C P LDGT C K C
Sbjct: 489 NEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAPGKHCF 546
Query: 337 KGRCRSLVELTP-IAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGA 395
KG C + LTP I G W +W P CSR+CG GV R RQC+NP PA GGR C G
Sbjct: 547 KGHC---IWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGL 603
Query: 396 DLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA--LCR 453
++C+ Q C + +F +QC + D L G A +HW +PH DA C
Sbjct: 604 AYDFQLCSRQDCPDSLADFREEQCRQWD---LYFEHGDAQ-HHW---LPHEHRDAKERCH 656
Query: 454 HMC--RAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 511
C R GE MKR DGTRC SLCV G CR GCDG + S +
Sbjct: 657 LYCESRETGEVVSMKR--MVHDGTRC-----SYKDAFSLCVRGDCRKVGCDGVIGSSKQE 709
Query: 512 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--I 568
D+C VCGGDNS C KG+FT + + Y+ + + I HLAV+
Sbjct: 710 DKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLE 769
Query: 569 GGRYVV--------AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE 620
G++++ + K I+ + EDGR E ++ GPL
Sbjct: 770 TGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR---------------ETLQTMGPLHG 814
Query: 621 DADIQVYRRYGEEYGNLTRPDITFTYF-------------QPKPRQAWVWAAVR-GPCSV 666
+ V G+ TR +T+ Y + + WA + PCS
Sbjct: 815 TITVLVI-PVGD-----TRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSK 868
Query: 667 SCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDFGPCSA 725
CG G ++ Y C + ++V C +P A AC + C P W G++ PCS
Sbjct: 869 PCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQ 928
Query: 726 SCG-GGLRERPVRCVE-AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPS 783
+CG G++ R VRC++ + +++ C + + C+ + CP RW S
Sbjct: 929 TCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPE---SRRACSRELCPGRWRAGPWS 985
Query: 784 SCTSAGGAG 792
C+ G G
Sbjct: 986 QCSVTCGNG 994
Score = 74.7 bits (182), Expect = 6e-13
Identities = 56/176 (31%), Positives = 72/176 (40%), Gaps = 12/176 (6%)
Query: 927 KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PR 984
K + CS CG G C R +++ C L +P+ + AC+ + C P
Sbjct: 862 KWSPCSKPCGGGSQFTKYGCRRRLDH----KMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 985 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTY 1043
W PCS +CG G RSV C+Q A RPE+ C C
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPG 977
Query: 1044 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
RW G W +CSV+CG+G Q R C A CQ +P T R C GPC
Sbjct: 978 RWRAGPWSQCSVTCGNGTQERPVLC----RTADDSFGICQE-ERPETARTCRLGPC 1028
Score = 73.6 bits (179), Expect = 1e-12
Identities = 54/179 (30%), Positives = 72/179 (40%), Gaps = 16/179 (8%)
Query: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 923
W+P CS CG G ++ C V C SKP + R C C P
Sbjct: 863 WSP----CSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVW 918
Query: 924 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 982
+ CS +CGR G+ R + C + D+ + C RPE + ACS E CP
Sbjct: 919 VTGEWEPCSQTCGRTGMQVRSVRCIQPL-HDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
Query: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
RW+ CS +CG GT R V C D + +E RPE + C + C
Sbjct: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-------RPETARTCRLGPC 1028
Score = 52.8 bits (125), Expect = 2e-06
Identities = 46/123 (37%), Positives = 58/123 (47%), Gaps = 22/123 (17%)
Query: 866 WTPAAGSCSVSCGRGLMELRFL-CM----DSALRVPVQEELCGLASKPGSRREVCQAVPC 920
W P CS +CGR M++R + C+ D+ R V + C A +P SRR C C
Sbjct: 923 WEP----CSQTCGRTGMQVRSVRCIQPLHDNTTR-SVHAKHCNDA-RPESRR-ACSRELC 975
Query: 921 PARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 979
P RW+ + CSV+CG G R + C A DD I CQ RPE C L
Sbjct: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTA---DDSFGI-----CQE-ERPETARTCRLG 1026
Query: 980 PCP 982
PCP
Sbjct: 1027 PCP 1029
Score = 47.8 bits (112), Expect = 7e-05
Identities = 40/129 (31%), Positives = 53/129 (41%), Gaps = 11/129 (8%)
Query: 985 WKVMSLGPCSASCGLGTARRSVAC-VQLDQGQDVEVDEAACAALVRPEA-SVPCLIADCT 1042
W + PCS CG G+ C +LD V CAAL +P+A C +C+
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKM---VHRGFCAALSKPKAIRRACNPQECS 914
Query: 1043 YR-WHVGTWMECSVSCG-DGIQRRRDTCLGP---QAQAPVPADFCQHLPKPVTVRGCWAG 1097
W G W CS +CG G+Q R C+ P V A C +P + R C
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND-ARPESRRACSRE 973
Query: 1098 PCVGQGACG 1106
C G+ G
Sbjct: 974 LCPGRWRAG 982
Score = 35.4 bits (80), Expect = 0.37
Identities = 42/154 (27%), Positives = 55/154 (35%), Gaps = 33/154 (21%)
Query: 262 WSPCS--------------RRQLLSLLSANEQCRVAFGPKAVACTFAREHLDMCQALSCH 307
WSPCS RR+L + C PKA+ + ++
Sbjct: 863 WSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGE 922
Query: 308 TDPLDQSS--------CSRLLVPLLDGTECGVE-KWCSKGRCRSLV----ELTPIAAVHG 354
+P Q+ R + PL D T V K C+ R S EL P G
Sbjct: 923 WEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP-----G 977
Query: 355 RWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 388
RW + GP S CS +CG G R C +FG
Sbjct: 978 RWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG 1010
Score = 34.7 bits (78), Expect = 0.63
Identities = 17/50 (34%), Positives = 20/50 (40%)
Query: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1092
Y W + W CS CG G Q + C V FC L KP +R
Sbjct: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIR 905
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 313 bits (803), Expect = 5e-85
Identities = 237/806 (29%), Positives = 360/806 (44%), Gaps = 82/806 (10%)
Query: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
+++R A G +E+L+ V V + H +E + YVLT +NI E+ D SLG + L
Sbjct: 249 RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
Query: 129 VKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
V+++++ + I N + SL VC W+ + +D + H D V+++TR D
Sbjct: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF---- 364
Query: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
G ++G + G C P SC + + GF IAHE GH G+EHDG G+GC
Sbjct: 365 GPSGMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQ-GNGCADETS 423
Query: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SANE 278
G VMA A WS CS+ +L L S +E
Sbjct: 424 LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDE 483
Query: 279 QCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKG 338
QCR FG C R + C+ L C + P + C P LDGTEC KWC KG
Sbjct: 484 QCRFDFGSGYQTCLAFRT-FEPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAPGKWCFKG 541
Query: 339 RCRSLVELTPIAAV--HGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 396
C + +P G WSSW CSRSCGGGV +R R CNNP PA+GGR C+G
Sbjct: 542 HC---IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPM 598
Query: 397 LQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD--ALCRH 454
+ ++CN++ C T +F +QQCA+ + + + + + W VP+ D C
Sbjct: 599 FEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAQKCEL 651
Query: 455 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 514
+C++ ++ DGTRC P S+C G C GCD + S + D+C
Sbjct: 652 ICQSADTGDVVFMNQVVHDGTRCSYRDP-----YSVCARGECVPVGCDKEVGSMKADDKC 706
Query: 515 QVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTP--------NLTSVYIANHRPLFTHLAV 566
VCGGDNS C KG T G+A + L + + ++ + HR + +
Sbjct: 707 GVCGGDNSHCRTVKG--TLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKN--- 761
Query: 567 RIGGRYVVAGKMSISPNTTYPSL---LEDGRVEYRVAL-TEDRLPRLEEIRIWGPLQEDA 622
++ G +++ K + + T+ ++ ED + + +L T LP I P +
Sbjct: 762 QVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGP 821
Query: 623 DIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLD 681
+ +Y L P I + + WA PCS +CG G+++ Y C
Sbjct: 822 RSSLAYKYVIHEDLL--PLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRR 879
Query: 682 QARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDFGPCSASCGG-GLRERPVRCV 739
+ +V+ C ++P C PC P W ++G CS SCG G++ R ++C+
Sbjct: 880 RRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCL 939
Query: 740 EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENET 799
+ + PA+ AG + A C PCPA+W + S C++ G G+
Sbjct: 940 LPLSNGTHKVMPAKACAGDRPE--ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVV 997
Query: 800 CVPGADGLEAPVTEGPGSVDE-KLPA 824
C A+ L + P +V LPA
Sbjct: 998 CRTNANSLGHCEGDRPDTVQVCSLPA 1023
Score = 88.6 bits (218), Expect = 4e-17
Identities = 65/196 (33%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 929 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWK 986
A CS +CG G+ C R + L C RP+P + C+ PC P W
Sbjct: 860 APCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKPIRRRCNQHPCSQPVWV 915
Query: 987 VMSLGPCSASCG-LGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYR 1044
G CS SCG LG R + C+ L G + ACA RPEA PCL C +
Sbjct: 916 TEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLRVPCPAQ 974
Query: 1045 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL--PKPVTVRGCWAGPCVGQ 1102
W +G W +CS +CG+GIQ+R+ C A+ H +P TV+ C
Sbjct: 975 WRLGAWSQCSATCGEGIQQRQVVC-------RTNANSLGHCEGDRPDTVQVC------SL 1021
Query: 1103 GACGRQHLEPTGTIDM 1118
ACG H T D+
Sbjct: 1022 PACGGNHQNSTVRADV 1037
Score = 73.6 bits (179), Expect = 1e-12
Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 9/146 (6%)
Query: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 923
W P CS +CG G+ ++ C VQ LC +P R C PC P
Sbjct: 859 WAP----CSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 914
Query: 924 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 982
+ ACS SCG+ GV R + C + +++ C G RPE + C PCP
Sbjct: 915 VTEEWGACSRSCGKLGVQTRGIQCLLPL-SNGTHKVMPAKACAG-DRPEARRPCLRVPCP 972
Query: 983 PRWKVMSLGPCSASCGLGTARRSVAC 1008
+W++ + CSA+CG G +R V C
Sbjct: 973 AQWRLGAWSQCSATCGEGIQQRQVVC 998
Score = 52.4 bits (124), Expect = 3e-06
Identities = 69/305 (22%), Positives = 97/305 (31%), Gaps = 78/305 (25%)
Query: 707 VLEPCPPY-WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 765
+LE Y WA+ + PCS +CGGG++ C + + ++P
Sbjct: 845 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIR 901
Query: 766 ETCNPQPCPAR-WEVSEPSSCT-SAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLP 823
CN PC W E +C+ S G G+ C+ V ++
Sbjct: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
Query: 824 APEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLME 883
A PC+ + CP W R GA W+ CS +CG G+ +
Sbjct: 962 ARRPCLRVPCPAQW-------------------RLGA-----WS----QCSATCGEGIQQ 993
Query: 884 LRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 943
+ +C +A L G R + Q PA CG
Sbjct: 994 RQVVCRTNA---------NSLGHCEGDRPDTVQVCSLPA------------CG------- 1025
Query: 944 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTAR 1003
G + D L PE Q EP P K+ S PC T
Sbjct: 1026 -------GNHQNSTVRADV--WELGTPEGQWVPQSEPLHPINKISSTEPC-------TGD 1069
Query: 1004 RSVAC 1008
RSV C
Sbjct: 1070 RSVFC 1074
Score = 41.6 bits (96), Expect = 0.005
Identities = 26/75 (34%), Positives = 32/75 (42%), Gaps = 10/75 (13%)
Query: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQH--LPKPVTVRGCWAGPC 1099
TY W + +W CS +CG GIQ + C + V C H PKP+ R C PC
Sbjct: 851 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIR-RRCNQHPC 909
Query: 1100 VGQ-------GACGR 1107
GAC R
Sbjct: 910 SQPVWVTEEWGACSR 924
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 312 bits (800), Expect = 1e-84
Identities = 240/812 (29%), Positives = 350/812 (43%), Gaps = 86/812 (10%)
Query: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
+R+R A ++E+L+ V V + H +E + Y+LT +NI E+ D SLG V L
Sbjct: 246 RRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVL 305
Query: 129 VKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
V+M++L + I N + SL +VC W+ D H D +++TR D
Sbjct: 306 VRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF---- 361
Query: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 362 GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDETA 420
Query: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SANE 278
G VMA A WS CS ++L + S +E
Sbjct: 421 MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDE 480
Query: 279 QCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKG 338
QCR FG CT R D C+ L C + P + C P LDGTEC KWC KG
Sbjct: 481 QCRFDFGVGYKMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAAGKWCYKG 538
Query: 339 RCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQ 398
C + + G W SW CSR+CG GV R RQCNNP P GG+ C G + +
Sbjct: 539 HC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFE 596
Query: 399 AEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRA 458
++CNT+ C+K +F +QQC + + + + +HW H C C++
Sbjct: 597 YQLCNTEECQKHFEDFRAQQCQQRNSHFEYQN----TKHHW-LPYEHPDPKKRCHLYCQS 651
Query: 459 IGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCG 518
+ DGT C P S+CV G C GCD + S +V D+C VCG
Sbjct: 652 KETGDVAYMKQLVHDGTHCSYKDP-----YSICVRGECVKVGCDKEIGSNKVEDKCGVCG 706
Query: 519 GDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGGRYVVA 575
GDNS C KG+FT R Y+ + P V I LA++ G Y++
Sbjct: 707 GDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILN 766
Query: 576 GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYG 635
GK + + T+ L VE+ + +D +E + GPL + + + + +
Sbjct: 767 GKGEEAKSRTFIDL----GVEWDYNIEDD----IESLHTDGPLHDPVIVLIIPQENDTRS 818
Query: 636 NLTR---------PDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARK 685
+LT P I + + WA CS CG G ++ Y C ++
Sbjct: 819 SLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDN 878
Query: 686 ELVETVQCQGSQQPPAWPEACVLEPCP-PYWAVGDFGPCSASCG-GGLRERPVRCVEAQG 743
++V C+ +++P C ++ C P W ++ C+ +CG G + R VRC+ Q
Sbjct: 879 KMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCL--QP 936
Query: 744 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 803
L T + + CN PCPA+W+ S C+ G G + C G
Sbjct: 937 LLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAG 996
Query: 804 --ADGLEAPVTEGPGSVDE-KLPA--PEPCVG 830
DG E P SV +LP EPC+G
Sbjct: 997 DHCDG------EKPESVRACQLPPCNDEPCLG 1022
Score = 75.5 bits (184), Expect = 3e-13
Identities = 54/180 (30%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWKVM 988
CS CG G C R +++ + C+ +P+P + C+++ C P W
Sbjct: 857 CSKPCGGGFQYTKYGCRRK----SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAE 912
Query: 989 SLGPCSASCGL-GTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1046
C+ +CG G R+V C+Q L G + V C RPE+ PC C +W
Sbjct: 913 EWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQWK 971
Query: 1047 VGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACG 1106
G W ECSV+CG+G + R+ C D C KP +VR C PC + G
Sbjct: 972 TGPWSECSVTCGEGTEVRQVLCRA--------GDHCDG-EKPESVRACQLPPCNDEPCLG 1022
Score = 66.2 bits (160), Expect = 2e-10
Identities = 50/172 (29%), Positives = 67/172 (38%), Gaps = 14/172 (8%)
Query: 873 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC------PARWQY 926
CS CG G ++ C + V C KP R +C C W++
Sbjct: 857 CSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEH 916
Query: 927 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRW 985
C+ +CG G R + C + D + C G RPE + C+ PCP +W
Sbjct: 917 ----CTKTCGSSGYQLRTVRCLQPL-LDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQW 970
Query: 986 KVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCL 1037
K CS +CG GT R V C D D E E+ A + P PCL
Sbjct: 971 KTGPWSECSVTCGEGTEVRQVLCRAGDH-CDGEKPESVRACQLPPCNDEPCL 1021
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/128 (28%), Positives = 51/128 (39%), Gaps = 9/128 (7%)
Query: 985 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE-ASVPCLIADCTY 1043
W + S CS CG G C + + + V + C A +P+ C I +CT+
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRR--KSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
Query: 1044 -RWHVGTWMECSVSCG-DGIQRRRDTCLGP---QAQAPVPADFCQHLPKPVTVRGCWAGP 1098
W W C+ +CG G Q R CL P V + +C +P + R C P
Sbjct: 907 PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVP 965
Query: 1099 CVGQGACG 1106
C Q G
Sbjct: 966 CPAQWKTG 973
Score = 37.7 bits (86), Expect = 0.075
Identities = 16/51 (31%), Positives = 23/51 (45%)
Query: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1092
T+ W + +W +CS CG G Q + C V FC+ KP +R
Sbjct: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIR 896
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 310 bits (795), Expect = 5e-84
Identities = 238/806 (29%), Positives = 359/806 (44%), Gaps = 85/806 (10%)
Query: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
+++R A G +E+L+ V V + H +E + YVLT +NI E+ D SLG + L
Sbjct: 249 RKRRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
Query: 129 VKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
V+++++ + I N + SL VC W+ + +D + H D V+++TR D P
Sbjct: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFG-PS 367
Query: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
G V G+ C P SC + + GF IAHE GH G+EHDG G+GC
Sbjct: 368 GYAPVTGM------CHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQ-GNGCADETS 420
Query: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SANE 278
G VMA A WS CS+ +L L S +E
Sbjct: 421 LGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDE 480
Query: 279 QCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKG 338
QCR FG C R + C+ L C + P + C P LDGTEC KWC KG
Sbjct: 481 QCRFDFGSGYQTCLAFRT-FEPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAPGKWCFKG 538
Query: 339 RCRSLVELTPIAAV--HGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 396
C + +P G WSSW CSRSCGGGV +R R CNNP PA+GGR C+G
Sbjct: 539 HC---IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPM 595
Query: 397 LQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD--ALCRH 454
+ ++CN++ C T +F +QQCA+ + + + + + W VP+ D C
Sbjct: 596 FEYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQN----AKHSW---VPYEPDDDAQKCEL 648
Query: 455 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 514
+C++ ++ DGTRC P S+C G C GCD + S + D+C
Sbjct: 649 ICQSADTGDVVFMNQVVHDGTRCSYRDP-----YSVCARGECVPVGCDKEVGSMKADDKC 703
Query: 515 QVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTP--------NLTSVYIANHRPLFTHLAV 566
VCGGDNS C KG T G+A + L + + ++ + HR + +
Sbjct: 704 GVCGGDNSHCRTVKG--TLGKASKQAGALKLVQIPAGARHIQIEALEKSPHRIVVKN--- 758
Query: 567 RIGGRYVVAGKMSISPNTTYPSL---LEDGRVEYRVAL-TEDRLPRLEEIRIWGPLQEDA 622
++ G +++ K + + T+ ++ ED + + +L T LP I P +
Sbjct: 759 QVTGSFILNPKGKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGP 818
Query: 623 DIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLD 681
+ +Y L P I + + WA PCS +CG G+++ Y C
Sbjct: 819 RSSLAYKYVIHEDLL--PLIGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRR 876
Query: 682 QARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDFGPCSASCGG-GLRERPVRCV 739
+ +V+ C ++P C PC P W ++G CS SCG G++ R ++C+
Sbjct: 877 RRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCL 936
Query: 740 EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENET 799
+ + PA+ AG + A C PCPA+W + S C++ G G+
Sbjct: 937 LPLSNGTHKVMPAKACAGDRPE--ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVV 994
Query: 800 CVPGADGLEAPVTEGPGSVDE-KLPA 824
C A+ L + P +V LPA
Sbjct: 995 CRTNANSLGHCEGDRPDTVQVCSLPA 1020
Score = 88.6 bits (218), Expect = 4e-17
Identities = 65/196 (33%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 929 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWK 986
A CS +CG G+ C R + L C RP+P + C+ PC P W
Sbjct: 857 APCSKACGGGIQFTKYGCRRRRDHHMVQRHL----CDHKKRPKPIRRRCNQHPCSQPVWV 912
Query: 987 VMSLGPCSASCG-LGTARRSVACV-QLDQGQDVEVDEAACAALVRPEASVPCLIADCTYR 1044
G CS SCG LG R + C+ L G + ACA RPEA PCL C +
Sbjct: 913 TEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPEARRPCLRVPCPAQ 971
Query: 1045 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHL--PKPVTVRGCWAGPCVGQ 1102
W +G W +CS +CG+GIQ+R+ C A+ H +P TV+ C
Sbjct: 972 WRLGAWSQCSATCGEGIQQRQVVC-------RTNANSLGHCEGDRPDTVQVC------SL 1018
Query: 1103 GACGRQHLEPTGTIDM 1118
ACG H T D+
Sbjct: 1019 PACGGNHQNSTVRADV 1034
Score = 73.6 bits (179), Expect = 1e-12
Identities = 47/146 (32%), Positives = 66/146 (45%), Gaps = 9/146 (6%)
Query: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 923
W P CS +CG G+ ++ C VQ LC +P R C PC P
Sbjct: 856 WAP----CSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 911
Query: 924 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 982
+ ACS SCG+ GV R + C + +++ C G RPE + C PCP
Sbjct: 912 VTEEWGACSRSCGKLGVQTRGIQCLLPL-SNGTHKVMPAKACAG-DRPEARRPCLRVPCP 969
Query: 983 PRWKVMSLGPCSASCGLGTARRSVAC 1008
+W++ + CSA+CG G +R V C
Sbjct: 970 AQWRLGAWSQCSATCGEGIQQRQVVC 995
Score = 52.4 bits (124), Expect = 3e-06
Identities = 69/305 (22%), Positives = 97/305 (31%), Gaps = 78/305 (25%)
Query: 707 VLEPCPPY-WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVAL 765
+LE Y WA+ + PCS +CGGG++ C + + ++P
Sbjct: 842 LLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRD---HHMVQRHLCDHKKRPKPIR 898
Query: 766 ETCNPQPCPAR-WEVSEPSSCT-SAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLP 823
CN PC W E +C+ S G G+ C+ V ++
Sbjct: 899 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 958
Query: 824 APEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLME 883
A PC+ + CP W R GA W+ CS +CG G+ +
Sbjct: 959 ARRPCLRVPCPAQW-------------------RLGA-----WS----QCSATCGEGIQQ 990
Query: 884 LRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 943
+ +C +A L G R + Q PA CG
Sbjct: 991 RQVVCRTNA---------NSLGHCEGDRPDTVQVCSLPA------------CG------- 1022
Query: 944 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTAR 1003
G + D L PE Q EP P K+ S PC T
Sbjct: 1023 -------GNHQNSTVRADV--WELGTPEGQWVPQSEPLHPINKISSTEPC-------TGD 1066
Query: 1004 RSVAC 1008
RSV C
Sbjct: 1067 RSVFC 1071
Score = 41.6 bits (96), Expect = 0.005
Identities = 26/75 (34%), Positives = 32/75 (42%), Gaps = 10/75 (13%)
Query: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQH--LPKPVTVRGCWAGPC 1099
TY W + +W CS +CG GIQ + C + V C H PKP+ R C PC
Sbjct: 848 TYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIR-RRCNQHPC 906
Query: 1100 VGQ-------GACGR 1107
GAC R
Sbjct: 907 SQPVWVTEEWGACSR 921
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 303 bits (777), Expect = 6e-82
Identities = 210/730 (28%), Positives = 313/730 (42%), Gaps = 89/730 (12%)
Query: 71 RQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVK 130
R++R ++E ++ + + H + Y+LT ++ A L + PS+ + +VK
Sbjct: 249 RKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVK 308
Query: 131 MVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNR 190
++++ + + P +T+N +L + C W + NP D D H D + TR DL
Sbjct: 309 ILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDL-CGSQTC 367
Query: 191 QVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG----SGCGPSG 246
G+ +G C P+ SC + ED G T AHE+GH F + HD A +G
Sbjct: 368 DTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDS 427
Query: 247 HVMASDGAAPRAGLAWSPCSRRQLLSLLS---------------------------ANEQ 279
H+MAS + WSPCS + S L AN Q
Sbjct: 428 HMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQ 487
Query: 280 CRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGR 339
C+ FG + C A C L C C P DGT CG KWC G+
Sbjct: 488 CQFTFGEDSKHCPDAAS---TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGK 544
Query: 340 CRSLVELTPI-AAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQ 398
C + + HG W WGP CSR+CGGGV R+C+NP P GG+ C G ++
Sbjct: 545 CVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVR 604
Query: 399 AEMCNTQAC-EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCR 457
CN + C + F +QC + ++S G W C+ +C+
Sbjct: 605 YRSCNLEDCPDNNGKTFREEQC-EAHNEFSKASFGSGPAVEWIPKYAGVSPKDRCKLICQ 663
Query: 458 AIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVC 517
A G + +DGT C P + S+CV G C GCD +DS++ +D+C VC
Sbjct: 664 AKGIGYFFVLQPKVVDGTPCSPD------STSVCVQGQCVKAGCDRIIDSKKKFDKCGVC 717
Query: 518 GGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANH-----RPLFTHLAVRIG-GR 571
GG+ STC GS T+ + Y +T+ T++ + R + LA++ G
Sbjct: 718 GGNGSTCKKISGSVTSAKP-GYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGT 776
Query: 572 YVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYG 631
Y++ G ++S +L +D + V LE IR + PL+E IQV
Sbjct: 777 YILNGDYTLS------TLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVL---- 826
Query: 632 EEYGNLTRPDITFTYFQPKPRQ---------AWV---WAAVRGPCSVSCGAGLRWVNYSC 679
GN RP I +TYF K ++ AWV W G CS SC G + C
Sbjct: 827 -TVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEW----GECSKSCELGWQRRLVEC 881
Query: 680 LD---QARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPV 736
D Q E + V+ PA C PC P W +G++ CS +CG G ++R +
Sbjct: 882 RDINGQPASECAKEVK-------PASTRPCADHPC-PQWQLGEWSSCSKTCGKGYKKRSL 933
Query: 737 RCVEAQGSLL 746
+C+ G +L
Sbjct: 934 KCLSHDGGVL 943
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 7/116 (6%)
Query: 973 QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEA 1032
+E+ + P W + G CS SC LG RR V C ++ GQ + CA V+P +
Sbjct: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDIN-GQPA----SECAKEVKPAS 900
Query: 1033 SVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKP 1088
+ PC C +W +G W CS +CG G ++R CL + + C L KP
Sbjct: 901 TRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHDG-GVLSHESCDPLKKP 954
Score = 43.9 bits (102), Expect = 0.001
Identities = 36/113 (31%), Positives = 50/113 (44%), Gaps = 12/113 (10%)
Query: 871 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 929
G CS SC G C D + P E C KP S R C PCP +WQ + +
Sbjct: 864 GECSKSCELGWQRRLVECRDINGQ-PASE--CAKEVKPASTRP-CADHPCP-QWQLGEWS 918
Query: 930 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPC 981
+CS +CG+G +R L C G +L C L +P+ + C++ C
Sbjct: 919 SCSKTCGKGYKKRSLKCLSHDG-----GVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 38.9 bits (89), Expect = 0.034
Identities = 22/55 (40%), Positives = 24/55 (43%), Gaps = 3/55 (5%)
Query: 1045 WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
W + W ECS SC G QRR C Q PA C KP + R C PC
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ---PASECAKEVKPASTRPCADHPC 909
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 287 bits (735), Expect = 4e-77
Identities = 221/799 (27%), Positives = 326/799 (40%), Gaps = 118/799 (14%)
Query: 55 PLKGRPPSPGFQRQRQRQRRAAGGIL---HLELLVAVGPDVFQAHQEDTERYVLTNLNIG 111
P K R G R R+R RA + ++E LV + + H D E Y+LT L
Sbjct: 190 PYKPRRAGFGESRSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATA 249
Query: 112 AELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGH 171
A L R PS+ + +VK+++L + + P +T N +L + C W + +N D P +
Sbjct: 250 ARLYRHPSILNPINIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEY 309
Query: 172 ADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFG 231
D + TR DL G+ +G C P SC + ED G T AHE+GH F
Sbjct: 310 WDTAILFTRQDL-CGATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFN 368
Query: 232 LEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA----------- 276
+ HD G + H+M+ WS CS + L +
Sbjct: 369 MPHDNVKVCEEVFGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPS 428
Query: 277 ----------------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLL 320
++QC +AFG + C + + C L C Q C
Sbjct: 429 KPISLPEDLPGASYTLSQQCELAFGVGSKPCPY----MQYCTKLWCTGKAKGQMVCQTRH 484
Query: 321 VPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQC 380
P DGT CG K C KG C L V G W+ W P PCSR+CGGGV RRQC
Sbjct: 485 FPWADGTSCGEGKLCLKGACVERHNLNK-HRVDGSWAKWDPYGPCSRTCGGGVQLARRQC 543
Query: 381 NNPRPAFGGRACVGADLQAEMCNTQACEKTQ--LEFMSQQCARTDG---QPLRSSPGGAS 435
NP PA GG+ C G ++ CN + C + F +QC +G R + A
Sbjct: 544 TNPTPANGGKYCEGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAW 603
Query: 436 FYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGS 495
+ P + C+ +CRA G + +DGT C P + S+CV G
Sbjct: 604 VPKYSGVSPRDK----CKLICRANGTGYFYVLAPKVVDGTLCSPD------STSVCVQGK 653
Query: 496 CRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAG-RAREYVTFLTVTPNLTSVYI 554
C GCDG + S++ +D+C VCGGDN +C G FT +V + + +
Sbjct: 654 CIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQ 713
Query: 555 ANHRPLF---THLAVRIG-GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLE 610
++ L +LA++ G+Y++ G +S ++ D V+ + +E
Sbjct: 714 RGYKGLIGDDNYLALKNSQGKYLLNGHFVVS------AVERDLVVKGSLLRYSGTGTAVE 767
Query: 611 EIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPK-------------------- 650
++ P+ E ++V G +T P + ++++ PK
Sbjct: 768 SLQASRPILEPLTVEVL-----SVGKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLH 822
Query: 651 ----------------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ 694
P WV A GPCS SCG+GL+ C A + TV
Sbjct: 823 NSVLSLSNQVEQPDDRPPARWV-AGSWGPCSASCGSGLQKRAVDCRGSAGQ---RTVPAC 878
Query: 695 GSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARC 754
+ P +AC EPCP W + + PCS SCG G + R ++CV G LL AR
Sbjct: 879 DAAHRPVETQACG-EPCPT-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLL-----ARD 931
Query: 755 RAGAQQPAVALETCNPQPC 773
+ + L+ C +PC
Sbjct: 932 QCNLHRKPQELDFCVLRPC 950
Score = 70.1 bits (170), Expect = 1e-11
Identities = 43/118 (36%), Positives = 54/118 (45%), Gaps = 7/118 (5%)
Query: 982 PPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
P RW S GPCSASCG G +R+V C +G + AC A RP + C +
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDC----RGSAGQRTVPACDAAHRPVETQAC--GEP 893
Query: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
W + W CS SCG G QRR C+G + + D C KP + C PC
Sbjct: 894 CPTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRL-LARDQCNLHRKPQELDFCVLRPC 950
Score = 55.5 bits (132), Expect = 3e-07
Identities = 39/111 (35%), Positives = 48/111 (43%), Gaps = 9/111 (8%)
Query: 871 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAA 930
G CS SCG GL + C SA + V C A +P + C PCP +
Sbjct: 849 GPCSASCGSGLQKRAVDCRGSAGQRTVPA--CDAAHRP-VETQAC-GEPCPTWELSAWSP 904
Query: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPC 981
CS SCGRG RR L C G +L QC +P+ + C L PC
Sbjct: 905 CSKSCGRGFQRRSLKCV-----GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 268 bits (684), Expect = 3e-71
Identities = 206/757 (27%), Positives = 309/757 (40%), Gaps = 111/757 (14%)
Query: 60 PPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPS 119
PP P R +R +E L+ + + D + ++LT +++ A + + PS
Sbjct: 201 PPPP--LGATSRTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPS 258
Query: 120 LGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYIT 179
+ + +VK++I+ + + P ++ N +L + C W + N D P H D + +T
Sbjct: 259 IKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLT 318
Query: 180 RFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG 239
R + +G GV +G C P SC + ED G T+AHE+GH + HD +
Sbjct: 319 RQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKP 378
Query: 240 SG--CGPSG--HVMASDGAAPRAGLAWSPCSRRQLLSLLSA------------------- 276
GP G HVMA L WSPCS L LL
Sbjct: 379 CTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAALPLPTG 438
Query: 277 ----------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTD---PLDQSSCSRLLVPL 323
++QCR FGP C D+C L CHTD PL + L P
Sbjct: 439 LPGRMALYQLDQQCRQIFGPDFRHCPNTSAQ-DVCAQLWCHTDGAEPLCHTKNGSL--PW 495
Query: 324 LDGTECGVEKWCSKGRCRSLVELT-PIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNN 382
DGT CG CS+G C E+ P G W+ WGP CSR+CGGGV R+C +
Sbjct: 496 ADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKD 555
Query: 383 PRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAA 442
P P GGR C+G + + C+T+ C F QQC + + G + W
Sbjct: 556 PEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDG--NLLQWVPK 613
Query: 443 VPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCD 502
C+ CRA G S +DGT C P TL++CV G C GCD
Sbjct: 614 YAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPE------TLAICVRGQCVKAGCD 667
Query: 503 GRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFT 562
+DS + D+C VCGG ++C GS T Y +T+ T++ + +
Sbjct: 668 HVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPTN-YGYNDIVTIPAGATNIDVKQR----S 722
Query: 563 HLAVRIGGRYVVA----GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPL 618
H V+ G Y+ G+ ++ N ++ +D V+ + + LE ++ + PL
Sbjct: 723 HPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPL 782
Query: 619 QEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYS 678
E +Q+ GE + P + +T+F P V++S
Sbjct: 783 PEPLTVQLLTVPGEVF----PPKVKYTFFVPND-----------------------VDFS 815
Query: 679 CLDQARKELVETVQCQGSQQPPAWPEACVLEP-CPPYWAVGDFGPCSASCGGGLRERPVR 737
Q+ KE T +++P W +GD+ CS++CG G + R V
Sbjct: 816 M--QSSKERATT---------------NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVE 858
Query: 738 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
C + G A C A +P A + C Q CP
Sbjct: 859 CRDPSGQ-----ASATCNK-ALKPEDA-KPCESQLCP 888
Score = 42.4 bits (98), Expect = 0.003
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 1044 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
+W +G W ECS +CG G QRR C P QA C KP + C + C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT---CNKALKPEDAKPCESQLC 887
Score = 33.5 bits (75), Expect = 1.4
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 5/53 (9%)
Query: 984 RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPC 1036
+W + CS++CG G RR+V C + GQ A C ++PE + PC
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVEC-RDPSGQ----ASATCNKALKPEDAKPC 882
Score = 31.6 bits (70), Expect = 5.3
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 5/55 (9%)
Query: 1021 EAACAALVRPEASVPCLIADCTYR-WHVGTWMECSVSCGDGIQRRRDTCLGPQAQ 1074
E +C L E P +AD + W G W ECS +CG G+Q C P+ Q
Sbjct: 509 EGSC--LPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHRECKDPEPQ 559
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 259 bits (661), Expect = 2e-68
Identities = 211/776 (27%), Positives = 312/776 (40%), Gaps = 94/776 (12%)
Query: 81 HLELLVAVGPDVFQAHQEDT-ERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEG 139
++E +V P + H D R++LT LN+ L + SL Q + ++K+++L E
Sbjct: 326 NIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLHETPP 385
Query: 140 APNITANLTSSLLSVCGWSQT-------INPEDDTDPGH----ADLVLYITRFDLEL-PD 187
I + L S C W I+ E T+ G D + ITR D + D
Sbjct: 386 ELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFCVHKD 445
Query: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPSGH 247
G+ L G CS C+I ED G +L TIAHE+GH+ G+ HD S C H
Sbjct: 446 EPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPS-CADGLH 504
Query: 248 VMASDGAAPR--AGLAWSPCSRRQLLSLL------------------------------S 275
+M+ + + ++WS CS+ L L +
Sbjct: 505 IMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYT 564
Query: 276 ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWC 335
A+EQC++ FGP A C +H+ +C L C + + C L P +DGT+C + KWC
Sbjct: 565 ADEQCQILFGPLASFCQ-EMQHV-ICTGLWCKVE--GEKECRTKLDPPMDGTDCDLGKWC 620
Query: 336 SKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGA 395
G C S A G WS W SPCSR+C G+ +R R+C P R C G
Sbjct: 621 KAGECTSRTSAPEHLA--GEWSLW---SPCSRTCSAGISSRERKC--PGLDSEARDCNGP 673
Query: 396 DLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHM 455
Q +C C F QC + SSP W A + + C
Sbjct: 674 RKQYRICENPPCPAGLPGFRDWQCQAYSVR--TSSP--KHILQWQAVLDEEKP---CALF 726
Query: 456 CRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQ 515
C +G+ + + +DGT C G L +C +G C+ GCDG + S D C
Sbjct: 727 CSPVGKEQPILLSEKVMDGTSCGYQG------LDICANGRCQKVGCDGLLGSLAREDHCG 780
Query: 516 VCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVA 575
VC G+ +C KG F R YV L + + + +P ++LA+R G+ +
Sbjct: 781 VCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQSIN 840
Query: 576 GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYG 635
I + + L V Y R E+I GP + V + YG
Sbjct: 841 SDWKIEHSGAFN--LAGTTVHY------VRRGLWEKISAKGPTTAPLHLLVLLFQDQNYG 892
Query: 636 ---NLTRPDITFTYFQ----PKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARK--E 686
T P Q P+P W + C +CG G R SC K
Sbjct: 893 LHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWE-DCDATCGGGERKTTVSCTKIMSKNIS 951
Query: 687 LVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE--AQGS 744
+V+ +C+ +P C +PC W + ++ PCS +CG G++ R V C + + G+
Sbjct: 952 IVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGT 1011
Query: 745 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 800
L++ AR R + + C Q C WE S C+ G G+ C
Sbjct: 1012 LIR----ARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC 1063
Score = 96.7 bits (239), Expect = 1e-19
Identities = 57/174 (32%), Positives = 82/174 (47%), Gaps = 11/174 (6%)
Query: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCPPRWKVMS 989
C +CG G + + C + ++ I+ + +C+ L +PEPQ C+ +PC RW +
Sbjct: 927 CDATCGGGERKTTVSCTKIMSKNIS--IVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTE 984
Query: 990 LGPCSASCGLGTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
PCS +CG G R VAC Q L G + E C +P ++ C DC W G
Sbjct: 985 WTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDCMTVWEAG 1043
Query: 1049 TWMECSVSCGDGIQRRRDTCLGPQAQA-----PVPADFCQHLPKPVTVR-GCWA 1096
W ECSV CG GI+ R C P+ + P A+ C+ K R G W+
Sbjct: 1044 VWSECSVKCGKGIRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRMGDWS 1097
Score = 94.0 bits (232), Expect = 9e-19
Identities = 67/256 (26%), Positives = 97/256 (37%), Gaps = 21/256 (8%)
Query: 850 PSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLC---MDSALRVPVQEELCGLA 905
P P + +WT + C +CG G + C M + + V E C
Sbjct: 903 PLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISI-VDNEKCKYL 961
Query: 906 SKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL-DTQ 963
+KP + C PC RW + CS +CG+G+ R + C + +G I +
Sbjct: 962 TKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS--NGTLIRARERD 1019
Query: 964 CQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAA 1023
C G P+P + C + C W+ CS CG G R+V C
Sbjct: 1020 CIG-PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN---------PRKK 1069
Query: 1024 CAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQ 1083
C RP + C Y W +G W +CS++CG G+Q R C+ + C
Sbjct: 1070 CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCM--HKITGRHGNECF 1127
Query: 1084 HLPKPVTVRGCWAGPC 1099
KP R C PC
Sbjct: 1128 SSEKPAAYRPCHLQPC 1143
Score = 84.7 bits (208), Expect = 5e-16
Identities = 59/276 (21%), Positives = 98/276 (35%), Gaps = 42/276 (15%)
Query: 715 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
W + C A+CGGG R+ V C + + + +C+ +P + CN QPC
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKY-LTKPEPQIRKCNEQPCQ 977
Query: 775 ARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP 834
RW ++E + C+ G G+ C + K + + C G C
Sbjct: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
Query: 835 PGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR 894
W A VW+ CSV CG+G+ C + +
Sbjct: 1038 TVW------------------------EAGVWS----ECSVKCGKGIRHRTVRCTNPRKK 1069
Query: 895 VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDD 954
C L+++P + C + CS++CG+G+ R++ C
Sbjct: 1070 -------CVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRH 1122
Query: 955 GEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 990
G E C +P C L+PC + V ++
Sbjct: 1123 GNE------CFSSEKPAAYRPCHLQPCNEKINVNTI 1152
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 248 bits (632), Expect = 4e-65
Identities = 216/819 (26%), Positives = 330/819 (40%), Gaps = 137/819 (16%)
Query: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 413
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
Query: 414 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 472
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
Query: 473 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 532
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G +
Sbjct: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYK 193
Query: 533 A--GRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLL 590
+ + T + + + + P HL + G+ S+S T+ L+
Sbjct: 194 SQLSATKSDDTVVAIPYGSRHIRLVLKGP--DHLYLETKTLQGTKGENSLSSTGTF--LV 249
Query: 591 EDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPK 650
++ V+++ + P E +R+ GPL D +++ R G + F ++QP
Sbjct: 250 DNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQFIFYQPI 297
Query: 651 PRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPPAWPEAC 706
+ W PCS +CG G + + C D +V C + +P + C
Sbjct: 298 IHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
Query: 707 VLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--AQGSLLK 747
L+PCP P W + CS+SCGGG++ R V CVE QG +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH-VT 413
Query: 748 TLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGA--- 804
++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 414 SVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
Query: 805 DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPW----GSIRTGA 860
G +P T+ + E+ P PC + +A PW + GA
Sbjct: 471 TGGCSPKTK--PHIKEECIVPTPC----------YKPKEKLPVEAKLPWFKQAQELEEGA 518
Query: 861 QAAH--VWTPAAGS-CSVSCGRGLMELRFLCM------DSALRVPVQEELCGLASKPGSR 911
+ + P A S C+V+CG G C S +P+ E C KP S+
Sbjct: 519 AVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDE--CE-GPKPASQ 575
Query: 912 REVCQAVPCPAR------------------------WQYK-LAACSVSCGRGVVRRILYC 946
R C A PC W+Y+ CS SCG GV ++ C
Sbjct: 576 R-ACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC 634
Query: 947 ARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSV 1006
+ EE L T + P+ ++C+L+PCP RW++ PCS +CG+G R V
Sbjct: 635 LNKQTREPAEENLCVTSRR---PPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDV 691
Query: 1007 ACVQL---DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQR 1063
C L + + V + + C +P C +C W+ W CS +CG G+Q+
Sbjct: 692 FCSHLLSREMNETVILADELCRQ-PKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQK 750
Query: 1064 RRDTCLGPQAQA---PVPADFCQHLPKPVTVRGCWAGPC 1099
R C A +P FC KP + C C
Sbjct: 751 REVLCKQRMADGSFLELPETFCS-ASKPACQQACKKDDC 788
Score = 184 bits (467), Expect = 5e-46
Identities = 142/514 (27%), Positives = 204/514 (39%), Gaps = 73/514 (14%)
Query: 644 FTYFQPKPR-QAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAW 702
+ + P PR +A W A CS SCG G++ SC+++ + V +V+ P
Sbjct: 371 YDLYHPLPRWEATPWTA----CSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKM 426
Query: 703 PEA--CVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQ 760
P A C + CP W ++ PC+ +CG GLR R V C++ +G P +
Sbjct: 427 PIAQPCNIFDCPK-WLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKT------K 479
Query: 761 PAVALETCNPQPCPARWE----------------------VSEP--------SSCTSAGG 790
P + E P PC E VSE S+CT G
Sbjct: 480 PHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG 539
Query: 791 AGLALENETCV------PGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 844
G + C L EGP ++ PC G
Sbjct: 540 VGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSG-------------E 586
Query: 845 AGEKAPSPWGSIRTGAQ---AAHVWT-PAAGSCSVSCGRGLMELRFLCMDSALRVPVQEE 900
E P + G Q + W CS SCG G+ E C++ R P +E
Sbjct: 587 IPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN 646
Query: 901 LCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEIL 959
LC + +P + C PCPARW+ K + CS++CG G+ R ++C+ + E ++
Sbjct: 647 LCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVI 706
Query: 960 LDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVE 1018
L + P+P +AC+ CPP W PCS +CG G +R V C Q + G +E
Sbjct: 707 LADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLE 766
Query: 1019 VDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQA 1075
+ E C+A +P C DC W + W ECS SCG+G Q R C L
Sbjct: 767 LPETFCSA-SKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLST 825
Query: 1076 PVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQH 1109
V + C LP ++R C C G +H
Sbjct: 826 VVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKH 859
Score = 107 bits (267), Expect = 8e-23
Identities = 69/234 (29%), Positives = 100/234 (42%), Gaps = 12/234 (5%)
Query: 872 SCSVSCG-RGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 929
+CS SCG RG+ + R C+ ++ V C +P + C CP+RW +
Sbjct: 1498 TCSASCGNRGVQQPRLRCLLNSTEVNPAH--CAGKVRPAVQPIACNRRDCPSRWMVTSWS 1555
Query: 930 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS 989
AC+ SCG GV R + C + + D Q RP +AC+ + C W S
Sbjct: 1556 ACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV-EWAFSS 1614
Query: 990 LGPCSASC---GLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1046
G C+ C L R V C D + + C+AL RP ++ C C+ W
Sbjct: 1615 WGQCNGPCIGPHLAVQHRQVFCQTRD---GITLPSEQCSALPRPVSTQNCWSEACSVHWR 1671
Query: 1047 VGTWMECSVSCGD-GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
V W C+ +CG+ G Q RR C+ + VP C P+P + C PC
Sbjct: 1672 VSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
Score = 82.0 bits (201), Expect = 3e-15
Identities = 54/179 (30%), Positives = 75/179 (41%), Gaps = 13/179 (7%)
Query: 927 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQE-ACSLEPCPPR 984
+LA CS SCG RGV + L C E + C G RP Q AC+ CP R
Sbjct: 1495 RLATCSASCGNRGVQQPRLRCLLNSTEVN------PAHCAGKVRPAVQPIACNRRDCPSR 1548
Query: 985 WKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEASVPCLIADCTY 1043
W V S C+ SCG G R V C +L G V C + +
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 1044 RWHVGTWMECSVSCGD---GIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
W +W +C+ C +Q R+ C + +P++ C LP+PV+ + CW+ C
Sbjct: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFC-QTRDGITLPSEQCSALPRPVSTQNCWSEAC 1666
Score = 77.4 bits (189), Expect = 9e-14
Identities = 70/274 (25%), Positives = 105/274 (38%), Gaps = 41/274 (14%)
Query: 653 QAWVWAAVR-GPCSVSCG-AGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP 710
Q + W+ R CS SCG G++ CL + + V C G +P P AC
Sbjct: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRD 1544
Query: 711 CPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKT-LPPARCRAGAQQPAVALETCN 769
CP W V + C+ SCGGG++ R V C + + S + T + C A++P V + CN
Sbjct: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP-VDTQACN 1603
Query: 770 PQPCPARWEVSEPSSCTS-AGGAGLALEN-ETCVPGADGLEAPVTEGPGSVDEKLPAPEP 827
Q C W S C G LA+++ + DG+ P ++ P P
Sbjct: 1604 QQLC-VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLP-------SEQCSALPRP 1655
Query: 828 CVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGR-GLMELRF 886
+C W + +WT C+ +CG G R
Sbjct: 1656 VSTQNC-------------------WSEACSVHWRVSLWT----LCTATCGNYGFQSRRV 1692
Query: 887 LCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 920
C+ + V E LC +P + + C PC
Sbjct: 1693 ECVHARTNKAVPEHLCSWGPRPANWQR-CNITPC 1725
Score = 76.3 bits (186), Expect = 2e-13
Identities = 51/138 (36%), Positives = 63/138 (45%), Gaps = 25/138 (18%)
Query: 985 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEAS-VPCLIADCT 1042
W V L CSASCG G + + C+ EV+ A CA VRP + C DC
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLL----NSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQA---QAPVPADFCQHLPK-PVTVRGC---- 1094
RW V +W C+ SCG G+Q RR TC +A PV D C + K PV + C
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 1095 ---WA--------GPCVG 1101
WA GPC+G
Sbjct: 1607 CVEWAFSSWGQCNGPCIG 1624
Score = 37.0 bits (84), Expect = 0.13
Identities = 36/97 (37%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 323 LLDGTECGVEKWCSKGRCRSLVELTPIAAVH----GRW--SSWGPRSPCSRSCGGGVVTR 376
LL+ TE V G+ R V+ PIA RW +SW S C+RSCGGGV TR
Sbjct: 1516 LLNSTE--VNPAHCAGKVRPAVQ--PIACNRRDCPSRWMVTSW---SACTRSCGGGVQTR 1568
Query: 377 RRQCNNPRPAFGGRACVGADLQAEMC----NTQACEK 409
R C + A G V D+ ++ +TQAC +
Sbjct: 1569 RVTCQKLK-ASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 245 bits (626), Expect = 2e-64
Identities = 219/809 (27%), Positives = 331/809 (40%), Gaps = 114/809 (14%)
Query: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 413
G W +WG S CSR+CGGG R+C GR C G +++ + C+ C +
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRC------LTGRNCEGQNIRYKTCSNHDCPPDAED 129
Query: 414 FMSQQCARTDGQPLRSSPGGASFYHWGAAVP-HSQGDALCRHMCRAIGESFIMKRGDSFL 472
F +QQC+ + + +Y W +P ++ A C C A G++ +++ L
Sbjct: 130 FRAQQCSAYNDVQYQGH-----YYEW---LPRYNDPAAPCALKCHAQGQNLVVELAPKVL 181
Query: 473 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 532
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC
Sbjct: 182 DGTRC------NTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTC-----RLV 230
Query: 533 AGRAREYVTFLTVTPNLTSVYIANHRPLFT-----HLAVRIGGRYVVAGKMSISPNTTYP 587
G+++ +V+ N+ +V + + T HL + + + K S N+
Sbjct: 231 RGQSKSHVSPEKREENVIAVPLGSRSVRITVKGPAHLFIE--SKTLQGSKGEHSFNSPGV 288
Query: 588 SLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYF 647
L+E+ VE++ R + +I GPL AD RY ++ + F ++
Sbjct: 289 FLVENTTVEFQ------RGSERQTFKIPGPLM--ADFIFKTRYTAAKDSV----VQFFFY 336
Query: 648 QPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPPAWP 703
QP Q W PC+V+CG G + + C+D K +V C + +P
Sbjct: 337 QPISHQ---WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKL 393
Query: 704 EACVLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--AQGS 744
+ C ++PCP P W + CS SCGGG++ R CVE G
Sbjct: 394 KECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGE 453
Query: 745 LLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PG 803
+L+ + +C A +P V ++TCN CP +W E S CT G GL C+
Sbjct: 454 ILQ-VEEWKCMY-APKPKV-MQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHR 509
Query: 804 ADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAA 863
+ + + + E+ P PC P ++A K R +
Sbjct: 510 GEHVGGCNPQLKLHIKEECVIPIPCYK---PKEKSPVEAKLPWLKQAQELEETRIATEEP 566
Query: 864 HVWTPAAGSCSVSCGRGL----MELRFLCMDSALRVPVQEELCGLASKPGSR---REVCQ 916
+CS +CG G+ ++ R L + + EE C P R E C
Sbjct: 567 TFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACD 626
Query: 917 AVPCPAR--------------WQYK-LAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 961
P W+Y C+ +C G I C ++ + D
Sbjct: 627 ESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI----QTQQTVND 682
Query: 962 TQCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVD 1020
+ C + RP +AC+ EPCPPRW V S GPCSA+CG+G R V C L G+
Sbjct: 683 SLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYC--LHPGETPAPP 740
Query: 1021 EAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC---LGPQAQAPV 1077
E +P A C DC WH+ W +CS +CG G Q RR TC L + +
Sbjct: 741 EECRDE--KPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNL 798
Query: 1078 PADFCQHLPKPVTVRGCWAGPCVGQGACG 1106
+ CQ PK + + C C A G
Sbjct: 799 SDELCQG-PKASSHKSCARTDCPPHLAVG 826
Score = 171 bits (432), Expect = 6e-42
Identities = 140/505 (27%), Positives = 206/505 (40%), Gaps = 86/505 (17%)
Query: 644 FTYFQPKPRQAWV---WAAVRGPCSVSCGAGLRWVNYSCLDQARKE---LVETVQCQGSQ 697
+ +FQP PR W W A CSVSCG G++ ++ C++++ VE +C +
Sbjct: 413 YDHFQPLPR--WEHNPWTA----CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAP 466
Query: 698 QPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL----------- 746
+P + C L CP W ++ C+ +CG GLR R V C+ +G +
Sbjct: 467 KPKVM-QTCNLFDCPK-WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHI 524
Query: 747 -------------KTLPPARCRAGAQQPAVALE-----TCNPQPCPARWEVSEPSSCTSA 788
K P + + A LE T P P W S+C++
Sbjct: 525 KEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPW-----SACSTT 579
Query: 789 GGAGLALENETC------VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDA 842
G G+ + C L EGP KLP PC+ +C D
Sbjct: 580 CGPGVQVREVKCRVLLTFTQTETELPEEECEGP-----KLPTERPCLLEAC-------DE 627
Query: 843 TSAGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEEL 901
+ A + P + ++ + W A + C+ +C G E +C+ + V + L
Sbjct: 628 SPASRELDIP---LPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSL 684
Query: 902 CGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILL 960
C + +P + + C PCP RW CS +CG G+ R +YC GE
Sbjct: 685 CDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-----GETPAP 739
Query: 961 DTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQL-DQGQDVEV 1019
+C+ +P +AC+ CPP W + CS +CG GT R V C QL G + +
Sbjct: 740 PEECRD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNL 798
Query: 1020 DEAACAALVRPEASV--PCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA-- 1075
+ C P+AS C DC VG W +CSVSCG GIQRR+ C A+
Sbjct: 799 SDELCQG---PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRR 855
Query: 1076 -PVPADFCQHLPKPVTVRGCWAGPC 1099
P+ C+ LP VR C C
Sbjct: 856 IPLSEMMCRDLPGLPLVRSCQMPEC 880
Score = 97.1 bits (240), Expect = 1e-19
Identities = 109/419 (26%), Positives = 153/419 (36%), Gaps = 91/419 (21%)
Query: 771 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEG-----PGSVDEKLPAP 825
QP +W ++ CT G G L + CV L+ V + P +V K P
Sbjct: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIR--LKRVVPDHYCHYYPENVKPK-PKL 393
Query: 826 EPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAH-VWTPAAGSCSVSCGRGLMEL 884
+ C CP +S G K P+ + + H WT +CSVSCG G+
Sbjct: 394 KECSMDPCP--------SSDGFKEIMPYDHFQPLPRWEHNPWT----ACSVSCGGGIQRR 441
Query: 885 RFLCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVR 941
F+C++ ++ + V+E C A KP + C CP + + C+V+CGRG+
Sbjct: 442 SFVCVEESMHGEILQVEEWKCMYAPKP-KVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRY 500
Query: 942 RILYCARAHGEDDG-----------EEILLDTQCQGLPRPEPQEA--------------- 975
R++ C GE G EE ++ C P EA
Sbjct: 501 RVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETR 560
Query: 976 -CSLEP--CPPRWKVMSLGPCSASCGLGTARRSVAC-VQLDQGQ-DVEVDEAACAALVRP 1030
+ EP P W CS +CG G R V C V L Q + E+ E C P
Sbjct: 561 IATEEPTFIPEPWSA-----CSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP 615
Query: 1031 EASVPCLIADC-------------------TYRWHVGTWMECSVSCGDGIQRRRDTCLGP 1071
PCL+ C TY W + C+ +C G Q CL
Sbjct: 616 -TERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHI 674
Query: 1072 QAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAVAI 1130
Q Q V C + +P P + Q AC + P + GP A C V I
Sbjct: 675 QTQQTVNDSLCDMVHRP---------PAMSQ-ACNTEPCPPRWHVGSWGPCSATCGVGI 723
Score = 93.6 bits (231), Expect = 1e-18
Identities = 70/237 (29%), Positives = 95/237 (40%), Gaps = 12/237 (5%)
Query: 866 WTPAAGS-CSVSCGR-GLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 923
W P S CS +CG G R C+ A V E LC KP + E C CPAR
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEALCDHLQKPLAGFEPCNIRDCPAR 1486
Query: 924 WQYKL-AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 982
W + + CSVSCG G R + C R +++ C RP ++ C PC
Sbjct: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGT-VQVVSPRACAPKDRPLGRKPCFGHPCV 1545
Query: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1042
+W+ + C C R+V Q ++ C RP C C
Sbjct: 1546 -QWEPGNR--CPGRC----MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
Query: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
WH G W C+ +CG G Q R+ C+ ++ PV C KP++ R C C
Sbjct: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 88.2 bits (217), Expect = 5e-17
Identities = 107/427 (25%), Positives = 164/427 (38%), Gaps = 68/427 (15%)
Query: 657 WAAVR-GPCSVSCGAGLRWVNYSCLDQA---------------RKELVETVQCQGSQQP- 699
W A+ C+V+CG GLR+ C++ ++E V + C ++
Sbjct: 482 WIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKS 541
Query: 700 ------PAWPEACVLEPC-----PPYWAVGDFGPCSASCGGGLRERPVRC-VEAQGSLLK 747
P +A LE P + + CS +CG G++ R V+C V + +
Sbjct: 542 PVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTE 601
Query: 748 T-LPPARC---RAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGG---AGLALENETC 800
T LP C + ++P + LE C+ P ++ P + AG TC
Sbjct: 602 TELPEEECEGPKLPTERPCL-LEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATC 660
Query: 801 VPGADGLEAPV--TEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRT 858
V G A + +V++ L C + PP T E P W
Sbjct: 661 VGGHQEAIAVCLHIQTQQTVNDSL-----CDMVHRPPAMSQACNT---EPCPPRW----- 707
Query: 859 GAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAV 918
HV + G CS +CG G+ C+ P E C KP + + C
Sbjct: 708 -----HV--GSWGPCSATCGVGIQTRDVYCLHPG-ETPAPPEEC-RDEKPHA-LQACNQF 757
Query: 919 PCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEI-LLDTQCQGLPRPEPQEAC 976
CP W + CS +CG G R + C + DG + L D CQG P+ ++C
Sbjct: 758 DCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQL--LTDGSFLNLSDELCQG-PKASSHKSC 814
Query: 977 SLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQL-DQGQDVEVDEAACAALVRPEASVP 1035
+ CPP V CS SCG+G RR C +L +G+ + + E C L
Sbjct: 815 ARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRS 874
Query: 1036 CLIADCT 1042
C + +C+
Sbjct: 875 CQMPECS 881
Score = 68.6 bits (166), Expect = 4e-11
Identities = 64/238 (26%), Positives = 92/238 (38%), Gaps = 32/238 (13%)
Query: 710 PCPPYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC 768
P P+W G++ CSA+CG G R + +CV A G + + A C Q+P E C
Sbjct: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANG---QEVSEALCDH-LQKPLAGFEPC 1478
Query: 769 NPQPCPARWEVSEPSSCTSAGGAGLALENETCV-PGADGLEAPVTEGPGSVDEKLPAPEP 827
N + CPARW S S C+ + G G TC A+G V+ + ++ +P
Sbjct: 1479 NIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKP 1538
Query: 828 CVGMSC---PPG----------------------WGHLDATSAGEKAPSPWGSIRTGAQA 862
C G C PG D+ K P+ + +GA
Sbjct: 1539 CFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACD 1598
Query: 863 AHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC 920
T C+ +CGRG + C+ + PV + C KP S R C C
Sbjct: 1599 VCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH-CLGPSC 1655
Score = 62.0 bits (149), Expect = 4e-09
Identities = 75/310 (24%), Positives = 103/310 (33%), Gaps = 52/310 (16%)
Query: 737 RCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSA-GGAGLAL 795
R V QG L R + P T P P WE S C++ G G +
Sbjct: 1393 RIVFLQGHKKYILQATNTRTNSNDP-----TGEPPPQEPFWEPGNWSHCSATCGHLGARI 1447
Query: 796 ENETCVPGADGLEAPVTEGP-GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWG 854
+ CV A+G E V+E + + L EPC CP W
Sbjct: 1448 QRPQCVM-ANGQE--VSEALCDHLQKPLAGFEPCNIRDCPARW----------------- 1487
Query: 855 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQ---EELCGLASKPGSR 911
+T CSVSCG G + C + VQ C +P R
Sbjct: 1488 -----------FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGR 1536
Query: 912 REVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 971
+ C PC +W+ GR V + + A H D+ C RP
Sbjct: 1537 KP-CFGHPC-VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSS-------DSNCDDRKRPT 1587
Query: 972 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
+ C+ C W PC+A+CG G R V C+ + V + C +P
Sbjct: 1588 LRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVA--KRHCVQKKKPI 1645
Query: 1032 ASVPCLIADC 1041
+ CL C
Sbjct: 1646 SWRHCLGPSC 1655
Score = 36.6 bits (83), Expect = 0.17
Identities = 14/43 (32%), Positives = 20/43 (46%)
Query: 700 PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQ 742
P C C W G + PC+A+CG G + R V C+ +
Sbjct: 1586 PTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTR 1628
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 244 bits (624), Expect = 3e-64
Identities = 191/643 (29%), Positives = 278/643 (43%), Gaps = 80/643 (12%)
Query: 54 APLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAE 113
APL P P +R +R A +E LV + H +RY+LT + A+
Sbjct: 198 APLGSPSPRP------RRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAK 251
Query: 114 LLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHAD 173
+ PS+ + + ++VIL E P + + +L S C W + +N +D+DP H D
Sbjct: 252 AFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFD 311
Query: 174 LVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLE 233
+ TR DL G+ +G C P SC I ED G T AHE+GH F +
Sbjct: 312 TAILFTRQDL-CGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 370
Query: 234 HDGAPG--SGCGP---SGHVMASDGAAPRAGLAWSPCSRRQLLSLLS------------- 275
HD + S GP S HVMA A WSPCS R + L
Sbjct: 371 HDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEA 430
Query: 276 --------------ANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLV 321
A+ QC++ FGP + C + C AL C + C
Sbjct: 431 PLHLPVTFPGKDYDADRQCQLTFGPDSRHCP---QLPPPCAALWCSGHLNGHAMCQTKHS 487
Query: 322 PLLDGTECGVEKWCSKGRCRSLVELTPIAAVH-GRWSSWGPRSPCSRSCGGGVVTRRRQC 380
P DGT CG + C GRC + +L G W WGP CSR+CGGGV R C
Sbjct: 488 PWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547
Query: 381 NNPRPAFGGRACVGADLQAEMCNTQACEK-TQLEFMSQQCA----RTDGQPLRSSPGGAS 435
P P GG+ C G + CNT+ C + L F +QCA RTD +S PG
Sbjct: 548 TRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTD--LFKSFPGPMD 605
Query: 436 FY-HWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSG 494
+ + P Q C+ +A+G ++++ +DGT C P + S+CV G
Sbjct: 606 WVPRYTGVAPQDQCKLTCQ--AQALGYYYVLE--PRVVDGTPCSPD------SSSVCVQG 655
Query: 495 SCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYI 554
C GCD + S++ +D+C VCGGD S CS + GSF R Y +T+ T + +
Sbjct: 656 RCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-YGYNNVVTIPAGATHILV 714
Query: 555 -----ANHRPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPR 608
HR ++ LA+++ G Y + G+ ++ P+ T ++ G V R +
Sbjct: 715 RQQGNPGHRSIY--LALKLPDGSYALNGEYTLMPSPT--DVVLPGAVSLRYS---GATAA 767
Query: 609 LEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP 651
E + GPL + +QV GN + +++F P+P
Sbjct: 768 SETLSGHGPLAQPLTLQVL-----VAGNPQDTRLRYSFFVPRP 805
Score = 31.2 bits (69), Expect = 7.0
Identities = 32/130 (24%), Positives = 43/130 (33%), Gaps = 32/130 (24%)
Query: 955 GEEILLDTQCQGLPRPEPQEACSLEP-CPPRWKVMSLGP---CSAS---------CGLGT 1001
G++ D QCQ P+ + L P C W L C CG
Sbjct: 440 GKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQ 499
Query: 1002 ARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGI 1061
A C+ +DQ QD + +A W G W +CS +CG G+
Sbjct: 500 ACMGGRCLHMDQLQDFNIPQAGGWG-----------------PW--GPWGDCSRTCGGGV 540
Query: 1062 QRRRDTCLGP 1071
Q C P
Sbjct: 541 QFSSRDCTRP 550
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 241 bits (614), Expect = 4e-63
Identities = 201/741 (27%), Positives = 309/741 (41%), Gaps = 92/741 (12%)
Query: 30 PSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVG 89
P+H S AL Q + S +P G P ++R+R+ RA +ELL+
Sbjct: 223 PAHSNPSGRAALASQLLDQ--SALSPAGGSGPQTWWRRRRRSISRAR----QVELLLVAD 276
Query: 90 PDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTS 149
+ + + + Y+LT +I L S+ R+ +VK+V+L + + + ++ N +
Sbjct: 277 ASMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAAT 336
Query: 150 SLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCL 209
+L + C W N D H D + TR DL + G+ +G CSP SC
Sbjct: 337 TLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDL-CGHHSCDTLGMADVGTICSPERSCA 395
Query: 210 ITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS----GCGPSGHVMASDGAAPRAGLAWSPC 265
+ ED G T+AHEIGH GL HD + G +M+S + A WS C
Sbjct: 396 VIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKC 455
Query: 266 S--------------------RRQLLS-------LLSANEQCRVAFGPKAVACTFAREHL 298
+ R+Q+L A +QC + FGP+ C +
Sbjct: 456 TSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCP----GM 511
Query: 299 DMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIA-AVHGRWS 357
D+C L C Q C +P ++GT CG + C +G+C + + + HG W
Sbjct: 512 DVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWG 571
Query: 358 SWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQ 417
SWG CSRSCGGGV R CNNP P GR C G C+ C F +
Sbjct: 572 SWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHE 631
Query: 418 QCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGTRC 477
QC +G + G +F W +C+ CRA G + + DGT C
Sbjct: 632 QCEAKNGYQ-SDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTEC 690
Query: 478 MPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAR 537
+ S+CV G C GCDG + S+ +D+C VCGGDNS+C+ G+F +++
Sbjct: 691 RLY------SNSVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK-KSK 743
Query: 538 EYVTFLTVTPNLTSVYI----ANHRPLFT-HLAV-RIGGRYVVAGKMSISPNTTYPSLLE 591
Y + + T + + A + FT +LA+ + G Y++ GK IS + T +
Sbjct: 744 GYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDING 803
Query: 592 DGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRP-DITFTYFQPK 650
+ +D L + + +E +Q+ + T+P D+ +++F PK
Sbjct: 804 TVMNYSGWSHRDDFLHGMG----YSATKEILIVQILAT------DPTKPLDVRYSFFVPK 853
Query: 651 PRQAWVWAA-----------------VRGP---CSVSCGAGLRWVNYSCLDQARKELVET 690
V + V GP CS +C G C D RK
Sbjct: 854 KSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRK---LA 910
Query: 691 VQCQGSQQPPAWPEACVLEPC 711
C SQ+P A+ + C+L+ C
Sbjct: 911 KGCPLSQRPSAFKQ-CLLKKC 930
Score = 33.5 bits (75), Expect = 1.4
Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 8/76 (10%)
Query: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSL 990
CS SCG GV +C ++G C G + +CSL PCPP K
Sbjct: 579 CSRSCGGGVQFAYRHCNNPAPRNNGR------YCTG--KRAIYRSCSLMPCPPNGKSFRH 630
Query: 991 GPCSASCGLGTARRSV 1006
C A G + + V
Sbjct: 631 EQCEAKNGYQSDAKGV 646
Score = 31.6 bits (70), Expect = 5.3
Identities = 46/212 (21%), Positives = 75/212 (35%), Gaps = 34/212 (16%)
Query: 583 NTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE-DADIQVYRRYGEEYGNLTRPD 641
+ T L+DG + L ++ EE+ P Q DA Q +G EY D
Sbjct: 457 SATITEFLDDGHGNCLLDLPRKQILGPEEL----PGQTYDATQQCNLTFGPEYSVCPGMD 512
Query: 642 ITFTYFQPKPRQAWVWAAVRGPCSVS---CGAGLRWVNYSCLDQARKELVETVQCQGSQQ 698
+ + RQ + + +V CG G + C+D+ +K+ T G+
Sbjct: 513 VCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYST-SSHGN-- 569
Query: 699 PPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGA 758
+ + G +G CS SCGGG++ C P R
Sbjct: 570 ---------------WGSWGSWGQCSRSCGGGVQFAYRHC-------NNPAPRNNGRYCT 607
Query: 759 QQPAVALETCNPQPCPARWEVSEPSSCTSAGG 790
+ A+ +C+ PCP + C + G
Sbjct: 608 GKRAI-YRSCSLMPCPPNGKSFRHEQCEAKNG 638
Score = 30.8 bits (68), Expect = 9.1
Identities = 13/38 (34%), Positives = 17/38 (44%)
Query: 713 PYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLP 750
P W G + CS +C G R V+C + L K P
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCP 914
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 220 bits (561), Expect = 6e-57
Identities = 208/724 (28%), Positives = 270/724 (37%), Gaps = 78/724 (10%)
Query: 392 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 451
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
Query: 452 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 511
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
Query: 512 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IG 569
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R G
Sbjct: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
Query: 570 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR 629
GR ++ G ++ P +Y + G +R + E + GP + D VY
Sbjct: 532 GRSIINGNWAVDPPGSYRA----GGTVFRYNRPPREEGKGESLSAEGPTTQPVD--VYMI 585
Query: 630 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE 689
+ EE P + + Y P P LR
Sbjct: 586 FQEE-----NPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPG 640
Query: 690 TVQCQGS--QQP-PAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLL 746
T+Q Q Q P P P + P YW CSASCG G+ C+ +
Sbjct: 641 TLQRQVRIPQMPAPPHPRTPLGSPAA-YWKRVGHSACSASCGKGVWRPIFLCISRESG-- 697
Query: 747 KTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVP--GA 804
+ L C AGA+ PA + E C+ PCP WE E +SC+ + G G C G
Sbjct: 698 EELDERSCAAGARPPA-SPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGG 756
Query: 805 DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGW-GHLDATSAGEKAPSPWGSIRTGAQAA 863
G P E G + P P + SC GH + S PW
Sbjct: 757 GGSSVP-PERCGHL------PRPNITQSCQLRLCGHWEVGS-------PWSQ-------- 794
Query: 864 HVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPAR 923
CSV CGRG + C+ + V E+ C RE C PC
Sbjct: 795 ---------CSVRCGRGQRSRQVRCVGNN-GDEVSEQECASGPPQPPSREACDMGPCTTA 844
Query: 924 WQYK--LAACSVSCGRGVVRRILYC---ARAHGEDDGEEILLDTQ-CQGLPRPEPQEACS 977
W + + CS CG G+ RR + C A G GE Q C RP ACS
Sbjct: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
Query: 978 LEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVP 1035
L PC RW G CS+ CG GT RR + CV + + C+ L RP A P
Sbjct: 905 LGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQP 964
Query: 1036 CLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCW 1095
C C RW W CS SC G Q R CL + C +P R C
Sbjct: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL---STRCPPQLRPSRKRPCN 1021
Query: 1096 AGPC 1099
+ PC
Sbjct: 1022 SQPC 1025
Score = 106 bits (264), Expect = 2e-22
Identities = 69/220 (31%), Positives = 92/220 (41%), Gaps = 20/220 (9%)
Query: 929 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 988
+ACS SCG+GV R I C + GEE+ + G P E C PCPP W+
Sbjct: 674 SACSASCGKGVWRPIFLCI---SRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
Query: 989 SLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
CS SCG GT R + C Q G V C L RP + C + C + W VG
Sbjct: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH-WEVG 789
Query: 1049 T-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVG------ 1101
+ W +CSV CG G + R+ C+G + P+P + C GPC
Sbjct: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSD 849
Query: 1102 -----QGACG----RQHLEPTGTIDMRGPGQADCAVAIGR 1132
CG R+ + G+ GPGQ + G+
Sbjct: 850 WSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
Score = 61.6 bits (148), Expect = 5e-09
Identities = 42/140 (30%), Positives = 60/140 (42%), Gaps = 12/140 (8%)
Query: 640 PDITFTYFQPKPRQAWVW-AAVRGPCSVSCGAGLRWVNYSCLDQARKE--LVETVQCQGS 696
PD+ P R W W G CS CG+G + + C+ + E + C
Sbjct: 898 PDMRACSLGPCER-TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHL 956
Query: 697 QQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRA 756
+PPA + C + C W + PCS SC GG + R V+C+ +L PP + R
Sbjct: 957 PRPPAL-QPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPP-QLRP 1014
Query: 757 GAQQPAVALETCNPQPCPAR 776
++P CN QPC R
Sbjct: 1015 SRKRP------CNSQPCSQR 1028
Score = 40.8 bits (94), Expect = 0.009
Identities = 52/202 (25%), Positives = 67/202 (33%), Gaps = 52/202 (25%)
Query: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 406
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
Query: 407 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 466
C QL HW P SQ C R+ +
Sbjct: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
Query: 467 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQ-------QVWDRCQVCGG 519
GD + C SGP + + C G C T S+ + R VC G
Sbjct: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
Query: 520 DNSTCSPRKGSFTAGRAREYVT 541
+ P +G AG + T
Sbjct: 872 SGAALGPGQGEAGAGTGQSCPT 893
Score = 37.4 bits (85), Expect = 0.097
Identities = 23/60 (38%), Positives = 27/60 (45%), Gaps = 2/60 (3%)
Query: 351 AVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG-ADLQAEMCNTQACEK 409
A RW S P SPCSRSC GG TR QC + R + CN+Q C +
Sbjct: 969 ACQDRWFST-PWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
Score = 33.1 bits (74), Expect = 1.8
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1050 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRG 1093
W CS CG G+QRR TC P Q P+P +H P+ + RG
Sbjct: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRG 99
Score = 31.6 bits (70), Expect = 5.3
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 383
G W W + CS+ CG GV R R C P
Sbjct: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 200 bits (508), Expect = 9e-51
Identities = 170/573 (29%), Positives = 229/573 (39%), Gaps = 98/573 (17%)
Query: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 415
W W SPCSR+CGGGV R R C + R GG +CVG C T++C +F
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 416 SQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMKRGDSFLDGT 475
++QCA DG + Y W +P+ C C GE+F K ++ +DGT
Sbjct: 88 AEQCAEFDGAEFQGRR-----YRW---LPYYSAPNKCELNCIPKGENFYYKHREAVVDGT 139
Query: 476 RCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGR 535
C P G +CV GSCR GCD +DS + D+C CGGD +TC P G+F A
Sbjct: 140 PCEP------GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA-- 191
Query: 536 AREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLLEDGRV 595
N S + N R G Y + G +I P+ +
Sbjct: 192 ------------NDLSRAVKNVR-----------GEYYLNGHWTIEAARALPA--ASTIL 226
Query: 596 EYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQP--KPRQ 653
Y D P E + GP E I++ + P + + Y P +P
Sbjct: 227 HYERGAEGDLAP--ERLHARGPTSEPLVIELISQE-------PNPGVHYEYHLPLRRPSP 277
Query: 654 AWVWA-AVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP 712
+ W+ CS CG G + C E CQ Q PA +C L PCP
Sbjct: 278 GFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQ-RQPRPADRRSCNLHPCP 334
Query: 713 --PYWAVGDFGPCSASCGGGLRERPVRCVEAQGS-LLKTLPPARCRAGAQQPAVALETCN 769
W G + PCSASCGGG + R V C+ + G+ + + + A C AG A++ CN
Sbjct: 335 ETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAEC-AGLPGKPPAIQACN 393
Query: 770 PQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCV 829
Q C A W C+ + G G+ + TC L + S++++ P EPCV
Sbjct: 394 LQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSL---LHTAACSLEDRPPLTEPCV 449
Query: 830 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 889
CP QA HV T G CS SC G + +C
Sbjct: 450 HEDCP----------------------LLSDQAWHVGT--WGLCSKSCSSGTRRRQVIC- 484
Query: 890 DSALRVPVQEELCGLA--SKPGSRREVCQAVPC 920
A+ P CG SKP E C PC
Sbjct: 485 --AIGPPSH---CGSLQHSKPVD-VEPCNTQPC 511
Score = 125 bits (315), Expect = 2e-28
Identities = 87/244 (35%), Positives = 116/244 (47%), Gaps = 23/244 (9%)
Query: 866 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW 924
W+ + S CS CG G C P + +C +P RR C PCP
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDHEAYP--DHMCQRQPRPADRRS-CNLHPCPETK 337
Query: 925 QYKL---AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP-RPEPQEACSLEP 980
++K A CS SCG G R +YC + G +E + + +C GLP +P +AC+L+
Sbjct: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGI-QEAVEEAECAGLPGKPPAIQACNLQR 396
Query: 981 CPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIAD 1040
C W G CS SCG+G +RSV C + ++G + AAC+ RP + PC+ D
Sbjct: 397 CAA-WSPEPWGECSVSCGVGVRKRSVTC-RGERGSLLHT--AACSLEDRPPLTEPCVHED 452
Query: 1041 CTY----RWHVGTWMECSVSCGDGIQRRRDTC-LGPQAQAPVPADFCQHLPKPVTVRGCW 1095
C WHVGTW CS SC G +RR+ C +GP P QH KPV V C
Sbjct: 453 CPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGP----PSHCGSLQH-SKPVDVEPCN 507
Query: 1096 AGPC 1099
PC
Sbjct: 508 TQPC 511
Score = 110 bits (276), Expect = 7e-24
Identities = 114/413 (27%), Positives = 150/413 (36%), Gaps = 84/413 (20%)
Query: 720 FGPCSASCGGGL--RERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARW 777
+ PCS +CGGG+ RERP G + PA + +C + CP
Sbjct: 35 WSPCSRTCGGGVSFRERPCYSQRRDGG-----------SSCVGPARSHRSCRTESCPDGA 83
Query: 778 EVSEPSSCTSAGGAGL-----------ALENE---TCVPGADGL----EAPVTEG----P 815
C GA + N+ C+P + V +G P
Sbjct: 84 RDFRAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEP 143
Query: 816 GSVD----------------EKLPAPEPCV-----GMSCPPGWGHLDATSAGEKAPSPWG 854
G D + + C+ G +C P G DA + G
Sbjct: 144 GKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRAVKNVRG 203
Query: 855 SIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSA-----LRVPVQE----ELCGLA 905
WT A + L R D A R P E EL
Sbjct: 204 EYYLNGH----WTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQE 259
Query: 906 SKPGSRREVCQAVPCPA---RWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLD 961
PG E + P+ W + + CS CG G R+++C H E D
Sbjct: 260 PNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH------EAYPD 313
Query: 962 TQCQGLPRPEPQEACSLEPCPP--RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVE 1018
CQ PRP + +C+L PCP RWK PCSASCG G+ RSV C+ D G
Sbjct: 314 HMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEA 373
Query: 1019 VDEAACAALV-RPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLG 1070
V+EA CA L +P A C + C W W ECSVSCG G+++R TC G
Sbjct: 374 VEEAECAGLPGKPPAIQACNLQRCA-AWSPEPWGECSVSCGVGVRKRSVTCRG 425
Score = 77.4 bits (189), Expect = 9e-14
Identities = 49/133 (36%), Positives = 62/133 (46%), Gaps = 20/133 (15%)
Query: 662 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP----PYWAV 717
G CSVSCG G+R + +C + R L+ T C +PP E CV E CP W V
Sbjct: 406 GECSVSCGVGVRKRSVTCRGE-RGSLLHTAACSLEDRPPL-TEPCVHEDCPLLSDQAWHV 463
Query: 718 GDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPC---- 773
G +G CS SC G R R V C PP+ C + V +E CN QPC
Sbjct: 464 GTWGLCSKSCSSGTRRRQVICAIG--------PPSHCGSLQHSKPVDVEPCNTQPCHLPQ 515
Query: 774 --PARWEVSEPSS 784
P+ +V P+S
Sbjct: 516 EVPSMQDVHTPAS 528
Score = 38.1 bits (87), Expect = 0.057
Identities = 37/102 (36%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 358 SWGPRSPCSRSCGGGVVTRRRQ--CNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFM 415
+WG CS+SC G TRRRQ C P+ G + E CNTQ C Q E
Sbjct: 465 TWGL---CSKSCSSG--TRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQ-EVP 518
Query: 416 SQQCARTDG----QPL--RSSPGGASFYHWGAAVPH--SQGD 449
S Q T PL + SP S W AA H ++GD
Sbjct: 519 SMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSARGD 560
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 164 bits (415), Expect = 5e-40
Identities = 135/504 (26%), Positives = 212/504 (42%), Gaps = 74/504 (14%)
Query: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLE 413
G W +WGP S CSR+CGGG R+C ++C G +++ C+ C +
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRC------LSSKSCEGRNIRYRTCSNVDCPPEAGD 87
Query: 414 FMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG-DALCRHMCRAIGESFIMKRGDSFL 472
F +QQC+ + FY W +P S D C C+A G + +++ L
Sbjct: 88 FRAQQCSAHNDVKHHGQ-----FYEW---LPVSNDPDNPCSLKCQAKGTTLVVELAPKVL 139
Query: 473 DGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFT 532
DGTRC +L +C+SG C+ GCD ++ S D C VC GD STC +G +
Sbjct: 140 DGTRCYTE------SLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYK 193
Query: 533 A--GRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAGKMSISPNTTYPSLL 590
+ + T + + + + P HL + G+ S+S T+ L+
Sbjct: 194 SQLSATKSDDTVVAIPYGSRHIRLVLKGP--DHLYLETKTLQGTKGENSLSSTGTF--LV 249
Query: 591 EDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPK 650
++ V+++ + P E +R+ GPL D +++ R G + F ++QP
Sbjct: 250 DNSSVDFQ------KFPDKEILRMAGPLTADFIVKI-RNSGS-----ADSTVQFIFYQPI 297
Query: 651 PRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQ---GSQQPPAWPEAC 706
+ W PCS +CG G + + C D +V C + +P + C
Sbjct: 298 IHR---WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
Query: 707 VLEPCP-----------------PYWAVGDFGPCSASCGGGLRERPVRCVE--AQGSLLK 747
L+PCP P W + CS+SCGGG++ R V CVE QG +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH-VT 413
Query: 748 TLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGA--- 804
++ +C + P + CN CP +W E S CT G GL C+
Sbjct: 414 SVEEWKCMYTPKMPIA--QPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMH 470
Query: 805 DGLEAPVTEGPGSVDEKLPAPEPC 828
G +P T+ + E+ P PC
Sbjct: 471 TGGCSPKTK--PHIKEECIVPTPC 492
Score = 79.7 bits (195), Expect = 2e-14
Identities = 52/174 (29%), Positives = 76/174 (43%), Gaps = 28/174 (16%)
Query: 919 PCPARW-QYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLP---RPEPQ- 973
P RW + CS +CG G C ++ D C P +P+P+
Sbjct: 296 PIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSN----RVVADQYCHYYPENIKPKPKL 351
Query: 974 EACSLEPCP-----------------PRWKVMSLGPCSASCGLGTARRSVACVQLD-QGQ 1015
+ C+L+PCP PRW+ CS+SCG G R+V+CV+ D QG
Sbjct: 352 QECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGH 411
Query: 1016 DVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCL 1069
V+E C + + PC I DC +W W C+V+CG G++ R C+
Sbjct: 412 VTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCI 464
Score = 63.2 bits (152), Expect = 2e-09
Identities = 46/193 (23%), Positives = 72/193 (37%), Gaps = 28/193 (14%)
Query: 873 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLAS---KPGSRREVCQAVPCPARWQYKL- 928
CS +CG G C D V ++ C KP + + C PCPA YK
Sbjct: 309 CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQI 368
Query: 929 -----------------AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPE 971
ACS SCG G+ R + C + + + +C P+
Sbjct: 369 MPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE-EWKCMYTPKMP 427
Query: 972 PQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
+ C++ CP +W PC+ +CG G R V C+ +G + C+ +P
Sbjct: 428 IAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCID-HRG----MHTGGCSPKTKPH 481
Query: 1032 ASVPCLIADCTYR 1044
C++ Y+
Sbjct: 482 IKEECIVPTPCYK 494
Score = 48.5 bits (114), Expect = 4e-05
Identities = 37/138 (26%), Positives = 50/138 (36%), Gaps = 22/138 (15%)
Query: 979 EPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV-------------------EV 1019
+P RW+ PCSA+CG G S C L + V E
Sbjct: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQEC 354
Query: 1020 DEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPA 1079
+ C A + +P + RW W CS SCG GIQ R +C+ Q V +
Sbjct: 355 NLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTS 414
Query: 1080 D---FCQHLPKPVTVRGC 1094
C + PK + C
Sbjct: 415 VEEWKCMYTPKMPIAQPC 432
Score = 46.2 bits (108), Expect = 2e-04
Identities = 51/219 (23%), Positives = 80/219 (36%), Gaps = 29/219 (13%)
Query: 771 QPCPARWEVSEPSSCTSAGGAGLALENETCVPGADG---LEAPVTEGPGSVDEKLPAPEP 827
QP RW ++ C++ G G L + C + P ++ K P +
Sbjct: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK-PKLQE 353
Query: 828 CVGMSCPPGWGHLDATSAGEKAPSP-WGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRF 886
C CP G+ P P W A WT +CS SCG G+
Sbjct: 354 CNLDPCPASDGYKQIMPYDLYHPLPRW--------EATPWT----ACSSSCGGGIQSRAV 401
Query: 887 LCMDSALR---VPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRI 943
C++ ++ V+E C K + C CP + + C+V+CG+G+ R+
Sbjct: 402 SCVEEDIQGHVTSVEEWKCMYTPKM-PIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRV 460
Query: 944 LYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSL-EPC 981
+ C G G C +P +E C + PC
Sbjct: 461 VLCIDHRGMHTG-------GCSPKTKPHIKEECIVPTPC 492
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 153 bits (387), Expect = 9e-37
Identities = 148/518 (28%), Positives = 202/518 (38%), Gaps = 82/518 (15%)
Query: 392 CVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL 451
C G Q C+ C Q + + QCA + Q Y W QG
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQ-----LYQW-EPFTEVQGSQR 417
Query: 452 CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 511
C CR G F ++ + DGT C P P +CV+G C + GCDG + S +
Sbjct: 418 CELNCRPRGFRFYVRHTEKVQDGTLCQPGAP------DICVAGRCLSPGCDGILGSGRRP 471
Query: 512 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--- 567
D C VCGGD+STC G+ T G Y L + + IA RP +LA+R
Sbjct: 472 DGCGVCGGDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG 531
Query: 568 ----IGGRYVV---------------------AGK---MSISPNTTYPSLL------EDG 593
I G + V GK +S TT P + E+
Sbjct: 532 GRSIINGNWAVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENP 591
Query: 594 RVEYRVALT-----------EDRLPRL--EEIRIWGPLQEDADIQVYRRYGEEYGNLTRP 640
V Y+ ++ E +P+L E +R+ PL R G L R
Sbjct: 592 GVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAP------RPARTPGTLQRQ 645
Query: 641 -DITFTYFQPKPRQ-----AWVWAAV-RGPCSVSCGAGLRWVNYSCLDQARKELVETVQC 693
I P PR A W V CS SCG G+ + C+ + E ++ C
Sbjct: 646 VRIPQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSC 705
Query: 694 QGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPAR 753
+PPA PE C PCPPYW G++ CS SCG G + R ++C + G ++PP R
Sbjct: 706 AAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPER 765
Query: 754 CRAGAQQPAVALETCNPQPCPARWEVSEP-SSCTSAGGAGLALENETCVPGADGLEAPVT 812
C +P + ++C + C WEV P S C+ G G CV G +G E
Sbjct: 766 C-GHLPRPNIT-QSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCV-GNNGDEVSEQ 821
Query: 813 EGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAP 850
E S + P+ E C C W H D +S P
Sbjct: 822 E-CASGPPQPPSREACDMGPCTTAWFHSDWSSKVSPEP 858
Score = 104 bits (259), Expect = 6e-22
Identities = 60/172 (34%), Positives = 78/172 (45%), Gaps = 5/172 (2%)
Query: 929 AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVM 988
+ACS SCG+GV R I C + GEE+ + G P E C PCPP W+
Sbjct: 674 SACSASCGKGVWRPIFLCI---SRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAG 730
Query: 989 SLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVG 1048
CS SCG GT R + C Q G V C L RP + C + C + W VG
Sbjct: 731 EWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGH-WEVG 789
Query: 1049 T-WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
+ W +CSV CG G + R+ C+G + P+P + C GPC
Sbjct: 790 SPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
Score = 99.8 bits (247), Expect = 2e-20
Identities = 79/259 (30%), Positives = 108/259 (41%), Gaps = 17/259 (6%)
Query: 795 LENETCVPGADGLEAPVTEGPGSVDEKL-PAPEPCVGMSCPPGWGHLDATSAGEKAPSPW 853
LEN T P L+ + V+ L PAP P + PG AP P
Sbjct: 606 LENPTPEPPVPQLQPEILR----VEPPLAPAPRP----ARTPGTLQRQVRIPQMPAP-PH 656
Query: 854 GSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRRE 913
G+ AA+ +CS SCG+G+ FLC+ + E C ++P + E
Sbjct: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
Query: 914 VCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP 972
C PCP W+ + +CS SCG G R L C + G G + +C LPRP
Sbjct: 717 PCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFG--GGGSSVPPERCGHLPRPNI 774
Query: 973 QEACSLEPCPPRWKVMS-LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE 1031
++C L C W+V S CS CG G R V CV + G +V E A + +P
Sbjct: 775 TQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVG-NNGDEVSEQECA-SGPPQPP 831
Query: 1032 ASVPCLIADCTYRWHVGTW 1050
+ C + CT W W
Sbjct: 832 SREACDMGPCTTAWFHSDW 850
Score = 37.0 bits (84), Expect = 0.13
Identities = 42/152 (27%), Positives = 52/152 (34%), Gaps = 45/152 (29%)
Query: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN-------TQA 406
G W+S CSRSCG G R+ QC R FGG G+ + E C TQ+
Sbjct: 730 GEWTS------CSRSCGPGTQHRQLQC---RQEFGGG---GSSVPPERCGHLPRPNITQS 777
Query: 407 CEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRAIGESFIMK 466
C QL HW P SQ C R+ +
Sbjct: 778 C---QLRLCG---------------------HWEVGSPWSQCSVRCGRGQRSRQVRCVGN 813
Query: 467 RGDSFLDGTRCMPSGPREDGTLSLCVSGSCRT 498
GD + C SGP + + C G C T
Sbjct: 814 NGDE-VSEQEC-ASGPPQPPSREACDMGPCTT 843
Score = 33.1 bits (74), Expect = 1.8
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 1050 WMECSVSCGDGIQRRRDTCLGPQAQ----APVPADFCQHLPKPVTVRG 1093
W CS CG G+QRR TC P Q P+P +H P+ + RG
Sbjct: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPPRPPRH-PEALLPRG 99
Score = 31.6 bits (70), Expect = 5.3
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 354 GRWSSWGPRSPCSRSCGGGVVTRRRQCNNP 383
G W W + CS+ CG GV R R C P
Sbjct: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 125 bits (313), Expect = 4e-28
Identities = 94/298 (31%), Positives = 137/298 (45%), Gaps = 38/298 (12%)
Query: 68 QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126
+R+ +R AA ++E+L+ V V Q H +E ++Y+LT +NI E+ D SLGA V
Sbjct: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
Query: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
LV++++L+ + I N + SL +VC W+ D + D +++TR D
Sbjct: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
Query: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG-QGNRCGDE 428
Query: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SA 276
G +MA A WS CS+++L L S
Sbjct: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSM 488
Query: 277 NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 334
NEQCR FG + CT R D C+ L C + P + C P LDGT C K+
Sbjct: 489 NEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAPGKF 544
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 124 bits (312), Expect = 5e-28
Identities = 106/422 (25%), Positives = 155/422 (36%), Gaps = 67/422 (15%)
Query: 715 WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP 774
W + PCSA+C G+ CV G + + C A +P E C + C
Sbjct: 568 WKLSSHEPCSATCTTGVMSAYAMCVRYDGV---EVDDSYCDA-LTRPEPVHEFCAGRECQ 623
Query: 775 ARWEVSEPSSCTSAGGAGLALENETC----VPGADG-LEAPVTEGPGSVDEKLPAPEPCV 829
RWE S S C+ G G C PG D + + + E +V + + C
Sbjct: 624 PRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPE--ERKTCR 681
Query: 830 GMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCM 889
+C P W S W C+ CG + R
Sbjct: 682 NPACGPQW-----------EMSEWSE-----------------CTAKCGERSVVTR---- 709
Query: 890 DSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYK-LAACSVSCGRGVVRRILYCAR 948
+R E+LC ++P + C PC +W CS SCG+G R +YC
Sbjct: 710 --DIRCSEDEKLCDPNTRPVGEKN-CTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCKT 766
Query: 949 AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVAC 1008
+ G ++ ++QCQ +P C + CP W C+ +CG G +R V C
Sbjct: 767 SDGR-----VVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLC 821
Query: 1009 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1068
++L G+ C +P C C ++W+ W EC+ +CG G++ R C
Sbjct: 822 MELANGKPQTRSGPECGLAKKPPEESTCFERPC-FKWYTSPWSECTKTCGVGVRMRDVKC 880
Query: 1069 LGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACGRQHLEPTGTIDMRGPGQADCAV 1128
Q C L KPV + C PC EP PG +CA+
Sbjct: 881 Y----QGTDIVRGCDPLVKPVGRQACDLQPC---------PTEPPDDSCQDQPG-TNCAL 926
Query: 1129 AI 1130
AI
Sbjct: 927 AI 928
Score = 116 bits (291), Expect = 1e-25
Identities = 110/409 (26%), Positives = 152/409 (37%), Gaps = 57/409 (13%)
Query: 638 TRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQ 697
TRP P W ++ PCS +C G+ C+ E V+ C
Sbjct: 551 TRPKARKQGVSPADMYRWKLSS-HEPCSATCTTGVMSAYAMCVRYDGVE-VDDSYCDALT 608
Query: 698 QPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVE-AQGSLLKTLPPARCRA 756
+P E C C P W + CS +CG G + R VRC + ++ C A
Sbjct: 609 RPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEA 668
Query: 757 GAQQPAVALETCNPQPCPARWEVSEPSSCTS-AGGAGLALENETCVPGADGLEAPVTEGP 815
+TC C +WE+SE S CT+ G + + C
Sbjct: 669 AEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRC--------------- 713
Query: 816 GSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAA-GSCS 874
S DEKL C P + GEK TG WT + G CS
Sbjct: 714 -SEDEKL----------CDP-----NTRPVGEKN-------CTGPPCDRQWTVSDWGPCS 750
Query: 875 VSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARW-QYKLAACSV 933
SCG+G C S RV V E C + +KP + C CPA W C+
Sbjct: 751 GSCGQGRTIRHVYCKTSDGRV-VPESQCQMETKPLAIHP-CGDKNCPAHWLAQDWERCNT 808
Query: 934 SCGRGVVRRILYCAR-AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGP 992
+CGRGV +R++ C A+G+ +C +P + C PC +W
Sbjct: 809 TCGRGVKKRLVLCMELANGKPQTRS---GPECGLAKKPPEESTCFERPC-FKWYTSPWSE 864
Query: 993 CSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
C+ +CG+G R V C QG D+ C LV+P C + C
Sbjct: 865 CTKTCGVGVRMRDVKCY---QGTDI---VRGCDPLVKPVGRQACDLQPC 907
Score = 99.0 bits (245), Expect = 3e-20
Identities = 80/306 (26%), Positives = 118/306 (38%), Gaps = 32/306 (10%)
Query: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPR----PAFGGRACVGADLQAEMCNTQACEKTQ 411
W W + CSRSCGGGV ++ R C R P G R C G + ++C Q C
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 412 LEFMSQQCARTDGQPLRSSPGGASFYHWGAAVP----HSQGDALCRHMCRAIGESFIMKR 467
F +QC S + W P H H G+ +M
Sbjct: 110 RSFREEQCVS-----FNSHVYNGRTHQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP 164
Query: 468 GDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPR 527
DGT C + R +CVSG C GCDG + S D+C +C GD S+C+
Sbjct: 165 AR---DGTSCKLTDLR-----GVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHV 216
Query: 528 KGSFTAGRAREYVTFLTVTP-NLTSVYIANHRPLFTHLAVR-IGGRYVVAGKMSISPNTT 585
G++ G A + +T P + I + LA+ G Y G +
Sbjct: 217 TGNYRKGNAHLGYSLVTHIPAGARDIQIVERKKSADVLALADEAGYYFFNGNYKVDSPKN 276
Query: 586 YPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFT 645
+ + V+YR + + +E I GP + ++ V+ + G+ P ITF
Sbjct: 277 FN--IAGTVVKYRRPM-DVYETGIEYIVAQGPTNQGLNVMVWNQNGKS------PSITFE 327
Query: 646 YFQPKP 651
Y +P
Sbjct: 328 YTLLQP 333
Score = 90.1 bits (222), Expect = 1e-17
Identities = 68/219 (31%), Positives = 94/219 (42%), Gaps = 31/219 (14%)
Query: 906 SKPGSRREVCQAVPCPARWQYKLAA---CSVSCGRGVVRRILYCARAHGEDDGEEILLDT 962
++P +R+ Q V +++KL++ CS +C GV+ C R DG E+ D+
Sbjct: 551 TRPKARK---QGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRY----DGVEVD-DS 602
Query: 963 QCQGLPRPEP-QEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQ-LDQGQDVEVD 1020
C L RPEP E C+ C PRW+ S CS +CG G R V C + L G D V
Sbjct: 603 YCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVY 662
Query: 1021 EAACAAL--VRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVP 1078
C A VRPE C C +W + W EC+ CG+ RD +
Sbjct: 663 SDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRD------IRCSED 716
Query: 1079 ADFCQHLPKPVTVRGCWAGPCVGQ----------GACGR 1107
C +PV + C PC Q G+CG+
Sbjct: 717 EKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQ 755
Score = 72.0 bits (175), Expect = 4e-12
Identities = 71/316 (22%), Positives = 105/316 (33%), Gaps = 60/316 (18%)
Query: 612 IRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAG 671
+R W L D VY E RP+ T P W + C+ CG
Sbjct: 647 VRCWKMLSPGFDSSVYSDLCEA-AEAVRPEERKTCRNPACGPQWEMSEW-SECTAKCGE- 703
Query: 672 LRWVNYSCLDQARKELVETVQCQGSQQ------PPAWPEACVLEPCPPYWAVGDFGPCSA 725
R + ++C ++ P + C PC W V D+GPCS
Sbjct: 704 ------------RSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSG 751
Query: 726 SCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSC 785
SCG G R V C + G + +P ++C+ + +A+ C + CPA W + C
Sbjct: 752 SCGQGRTIRHVYCKTSDG---RVVPESQCQ--METKPLAIHPCGDKNCPAHWLAQDWERC 806
Query: 786 TSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSA 845
+ G G+ C+ A+G + + +K P C C +
Sbjct: 807 NTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWY-------- 858
Query: 846 GEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLA 905
SPW C+ +CG G+ C V C
Sbjct: 859 ----TSPW-----------------SECTKTCGVGVRMRDVKCYQGTDIV----RGCDPL 893
Query: 906 SKPGSRREVCQAVPCP 921
KP R+ C PCP
Sbjct: 894 VKPVG-RQACDLQPCP 908
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.449
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,284,260
Number of Sequences: 37866
Number of extensions: 3548916
Number of successful extensions: 11488
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 9190
Number of HSP's gapped (non-prelim): 1081
length of query: 1340
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1226
effective length of database: 13,930,794
effective search space: 17079153444
effective search space used: 17079153444
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.