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Search of human proteins with 21265037
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21265037 ADAM metallopeptidase with thrombospondin type 1
motif, 3 proprotein [Homo sapiens]
(1205 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 2554 0.0
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 1389 0.0
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 1382 0.0
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 1370 0.0
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 675 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 550 e-156
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 535 e-151
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 512 e-145
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 497 e-140
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 484 e-136
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 474 e-133
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 469 e-132
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 456 e-128
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 436 e-122
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 426 e-119
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 413 e-115
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 393 e-109
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 377 e-104
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 374 e-103
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 324 3e-88
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 324 3e-88
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 313 8e-85
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 312 1e-84
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 233 8e-61
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 233 8e-61
gi|145309328 papilin [Homo sapiens] 230 5e-60
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 214 4e-55
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 185 3e-46
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 180 8e-45
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 178 2e-44
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 2554 bits (6619), Expect = 0.0
Identities = 1205/1205 (100%), Positives = 1205/1205 (100%)
Query: 1 MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHT 60
MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHT
Sbjct: 1 MVLLSLWLIAAALVEVRTSADGQAGNEEMVQIDLPIKRYREYELVTPVSTNLEGRYLSHT 60
Query: 61 LSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNI 120
LSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNI
Sbjct: 61 LSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNI 120
Query: 121 TDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYF 180
TDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYF
Sbjct: 121 TDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYF 180
Query: 181 IEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQ 240
IEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQ
Sbjct: 181 IEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQ 240
Query: 241 LNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVH 300
LNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVH
Sbjct: 241 LNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVH 300
Query: 301 INVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQD 360
INVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQD
Sbjct: 301 INVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQD 360
Query: 361 FGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA 420
FGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA
Sbjct: 361 FGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA 420
Query: 421 MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDE 480
MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDE
Sbjct: 421 MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDE 480
Query: 481 QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC 540
QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC
Sbjct: 481 QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC 540
Query: 541 MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLC 600
MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLC
Sbjct: 541 MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLC 600
Query: 601 NTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYM 660
NTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYM
Sbjct: 601 NTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYM 660
Query: 661 KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT 720
KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT
Sbjct: 661 KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT 720
Query: 721 RTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDL 780
RTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDL
Sbjct: 721 RTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDL 780
Query: 781 GVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVI 840
GVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVI
Sbjct: 781 GVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVI 840
Query: 841 QEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCN 900
QEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCN
Sbjct: 841 QEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCN 900
Query: 901 IQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP 960
IQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP
Sbjct: 901 IQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP 960
Query: 961 CNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPC 1020
CNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPC
Sbjct: 961 CNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPC 1020
Query: 1021 LGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLP 1080
LGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLP
Sbjct: 1021 LGDKSIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDVISNPSDLP 1080
Query: 1081 RSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSK 1140
RSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSK
Sbjct: 1081 RSLVMPTSLVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSK 1140
Query: 1141 TVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRS 1200
TVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRS
Sbjct: 1141 TVRLVTVPSSPPTKRVHLSSASQMAAASFFAASDSIGASSQARTSKKDGKIIDNRRPTRS 1200
Query: 1201 STLER 1205
STLER
Sbjct: 1201 STLER 1205
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 1389 bits (3594), Expect = 0.0
Identities = 656/1070 (61%), Positives = 797/1070 (74%), Gaps = 77/1070 (7%)
Query: 35 PIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNP---------------EQ 79
P+ E L PV T+ +GR +SH +SA+ + R + P
Sbjct: 49 PLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSH 108
Query: 80 LFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKT 139
LF+N+T FG+D HLRL+PN +LVAPGA +EW Q T R+
Sbjct: 109 LFYNVTVFGRDLHLRLRPNARLVAPGATMEW-----------------QGEKGTTRV--- 148
Query: 140 EPLQTNCAYVGDIVDIP-GTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEE-EKGRI 197
EPL +C YVGD+ + +SVA+SNCDGLAG+I+ + EE+FIEPLE+G +E E+GR+
Sbjct: 149 EPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV 208
Query: 198 HVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRR-RRHAGENDY 256
HVVY+R P+ + S L+ LD L G + + N + RR RRHA ++DY
Sbjct: 209 HVVYRRPPTSP-PLGGPQALDTGAS-LDSLDSLSRALGVLEEHANSSRRRARRHAADDDY 266
Query: 257 NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKS 316
NIEVLLGVDDSVV+FHGKEHVQ YLLTLMNIVNEIYHDESLG HINVVLVR+I+L Y KS
Sbjct: 267 NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKS 326
Query: 317 ISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMC 376
+SLIE GNPS+SLENVCRWA QQ+ D H E+HDHAIFLTRQDFGP+GMQGYAPVTGMC
Sbjct: 327 MSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMC 386
Query: 377 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRY 436
HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE +GS+MAPLVQAAFHR+
Sbjct: 387 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRF 446
Query: 437 HWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAF 496
HWSRCS QEL RY+HSYDCLLDDPF HDWP LP+LPG++YSM+EQCRFDFG+GY MCTAF
Sbjct: 447 HWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAF 506
Query: 497 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGS 556
RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGT CA GK C+KGHC+W + K+DG+WG+
Sbjct: 507 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGA 566
Query: 557 WTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQ 616
W+ FGSCSRTCGTGV+FRTRQC+NP P NGG+ C G+ +++QLC+ ++C DFR +Q
Sbjct: 567 WSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQ 626
Query: 617 CQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPY 676
C+Q + +FE+ + +HHWLP+EH D K+RCHLYC+S+ETG+V MK++VHDGT CSYKD +
Sbjct: 627 CRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAF 686
Query: 677 SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPP 736
S+CVRG+C KVGCD IGS+K EDKCGVCGGDNSHC+ VKGTFTR+P+K GY+KMF+IP
Sbjct: 687 SLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPA 746
Query: 737 GARHVLIQEDEASPHILAIKNQATGHYILNGKGE-EAKSRTFIDLGVEWDYNIEDDIESL 795
GARH+LIQE +A+ H LA+KN TG +ILN + + +A S+TFI +GVEW+Y ED E+L
Sbjct: 747 GARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETL 806
Query: 796 HTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWS 855
T GPLH + VL+IP DTR SLTYKY+IHEDS+ ++ NNV++E+ +EWALK WS
Sbjct: 807 QTMGPLHGTITVLVIPV-GDTRVSLTYKYMIHEDSL-NVDDNNVLEEDSVVYEWALKKWS 864
Query: 856 QCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWE 915
CSKPCGGG Q+TKYGCRR+ D+KMVHR FC A KPK IRR CN QEC+ P+WV EWE
Sbjct: 865 PCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWE 924
Query: 916 HCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPW 975
C++TCG +G Q+R+VRC+QPL D T RSVH+K+C RPESRR C+R CP +W+ GPW
Sbjct: 925 PCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPW 984
Query: 976 SECSVTCGEGTEVRQVLCRAGDH----CDGEKPESVRACQLPPCN--------------- 1016
S+CSVTCG GT+ R VLCR D C E+PE+ R C+L PC
Sbjct: 985 SQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQW 1044
Query: 1017 ------DEP---------CLGDKSIFCQMEVLARYCSIPGYNKLCCESCS 1051
D P C GDKSIFC+MEVL+RYCSIPGYNKLCC+SC+
Sbjct: 1045 LSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCN 1094
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 1382 bits (3577), Expect = 0.0
Identities = 653/1166 (56%), Positives = 796/1166 (68%), Gaps = 101/1166 (8%)
Query: 41 EYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNP----------------------- 77
+Y + P ST+ GR+LSH +S + V P
Sbjct: 37 DYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTL 96
Query: 78 -------EQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPG 130
L+FN+T FGK+ HLRL+PN +LV PG+ VEW E
Sbjct: 97 WPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQED----------------- 139
Query: 131 SATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQM 190
+R +PL+ C Y G + +PG +VAISNCDGLAG+I++D+ ++FIEPLERG+Q
Sbjct: 140 ---FRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQE 196
Query: 191 EEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRH 250
+E GR HVVY+R AV+Q + D H ++ GL DL + G + QL +T R+RRH
Sbjct: 197 KEASGRTHVVYRREAVQQEWAEPDGDLH---NEAFGLGDLPNLLGLVGDQLGDTERKRRH 253
Query: 251 AGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIM 310
A Y+IEVLL VDDSVVRFHGKEHVQNY+LTLMNIV+EIYHDESLGVHIN+ LVR+IM
Sbjct: 254 AKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIM 313
Query: 311 LGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYA 370
+GY +S+SLIERGNPSRSLE VCRWA QQR D +H+EHHDH +FLTRQDFGP+GMQGYA
Sbjct: 314 VGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSGMQGYA 373
Query: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQ 430
PVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DET++GSVMAPLVQ
Sbjct: 374 PVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQ 433
Query: 431 AAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGY 490
AAFHR+HWSRCS EL RY+ SYDCLLDDPFD WP+ PELPGINYSMDEQCRFDFG GY
Sbjct: 434 AAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGY 493
Query: 491 KMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQ-QK 549
+ C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGTECA GKWC+KGHC+WK+ Q
Sbjct: 494 QTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYG 553
Query: 550 QDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHF 609
QDG W SWTKFGSCSR+CG GVR R+R CNNP P GG+ C G FEYQ+CN+EEC +
Sbjct: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 613
Query: 610 EDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTH 669
EDFRAQQC +RNS++ +QN KH W+PYE D ++C L CQS +TGDV +M Q+VHDGT
Sbjct: 614 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 673
Query: 670 CSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYL 729
CSY+DPYS+C RGECV VGCDKE+GS K +DKCGVCGGDNSHCRTVKGT + ++ G L
Sbjct: 674 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 733
Query: 730 KMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIE 789
K+ IP GARH+ I+ E SPH + +KNQ TG +ILN KG+EA SRTF +G+EW+ +E
Sbjct: 734 KLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVE 793
Query: 790 DDIESLHTDGPLHDPVIVLII-PQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFE 848
D ESL T GPL + + +L + P E RSSL YKY+IHED +P I SNNV+ EE+DT+E
Sbjct: 794 DAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYE 853
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
WALKSW+ CSK CGGG Q+TKYGCRR+ D+ MV R C+ K+PKPIRR CN C+ P+
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPA 968
WV EEW C+++CG G Q R ++CL PL +GT++ + +K C GDRPE+RRPC RVPCPA
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
Query: 969 QWKTGPWSECSVTCGEGTEVRQVLCRAG----DHCDGEKPESVRACQLPPC--------- 1015
QW+ G WS+CS TCGEG + RQV+CR HC+G++P++V+ C LP C
Sbjct: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1033
Query: 1016 ----------------------------NDEPCLGDKSIFCQMEVLARYCSIPGYNKLCC 1047
+ EPC GD+S+FCQMEVL RYCSIPGY++LCC
Sbjct: 1034 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1093
Query: 1048 ESCSKRSS-----TLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMS 1102
SC K++S P P L T + P D + P +
Sbjct: 1094 VSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQ 1153
Query: 1103 LSSISSVGGPNAYAAFRPNSKPDGAN 1128
L P F P + GA+
Sbjct: 1154 LPGALDTSSPGTQHPFAPETPIPGAS 1179
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 1370 bits (3547), Expect = 0.0
Identities = 650/1166 (55%), Positives = 793/1166 (68%), Gaps = 104/1166 (8%)
Query: 41 EYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNP----------------------- 77
+Y + P ST+ GR+LSH +S + V P
Sbjct: 37 DYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTPPTLPRHSSHLRVARSPLHPGGTL 96
Query: 78 -------EQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPG 130
L+FN+T FGK+ HLRL+PN +LV PG+ VEW E
Sbjct: 97 WPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSSVEWQED----------------- 139
Query: 131 SATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQM 190
+R +PL+ C Y G + +PG +VAISNCDGLAG+I++D+ ++FIEPLERG+Q
Sbjct: 140 ---FRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLERGQQE 196
Query: 191 EEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRH 250
+E GR HVVY+R AV+Q + D H ++ GL DL + G + QL +T R+RRH
Sbjct: 197 KEASGRTHVVYRREAVQQEWAEPDGDLH---NEAFGLGDLPNLLGLVGDQLGDTERKRRH 253
Query: 251 AGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIM 310
A Y+IEVLL VDDSVVRFHGKEHVQNY+LTLMNIV+EIYHDESLGVHIN+ LVR+IM
Sbjct: 254 AKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIM 313
Query: 311 LGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYA 370
+GY +S+SLIERGNPSRSLE VCRWA QQR D +H+EHHDH +FLTRQDFGP+G YA
Sbjct: 314 VGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSG---YA 370
Query: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQ 430
PVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DET++GSVMAPLVQ
Sbjct: 371 PVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQ 430
Query: 431 AAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGY 490
AAFHR+HWSRCS EL RY+ SYDCLLDDPFD WP+ PELPGINYSMDEQCRFDFG GY
Sbjct: 431 AAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGY 490
Query: 491 KMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQK- 549
+ C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGTECA GKWC+KGHC+WK+ Q
Sbjct: 491 QTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYG 550
Query: 550 QDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHF 609
QDG W SWTKFGSCSR+CG GVR R+R CNNP P GG+ C G FEYQ+CN+EEC +
Sbjct: 551 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTY 610
Query: 610 EDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTH 669
EDFRAQQC +RNS++ +QN KH W+PYE D ++C L CQS +TGDV +M Q+VHDGT
Sbjct: 611 EDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTR 670
Query: 670 CSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYL 729
CSY+DPYS+C RGECV VGCDKE+GS K +DKCGVCGGDNSHCRTVKGT + ++ G L
Sbjct: 671 CSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGAL 730
Query: 730 KMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIE 789
K+ IP GARH+ I+ E SPH + +KNQ TG +ILN KG+EA SRTF +G+EW+ +E
Sbjct: 731 KLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVE 790
Query: 790 DDIESLHTDGPLHDPVIVLII-PQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFE 848
D ESL T GPL + + +L + P E RSSL YKY+IHED +P I SNNV+ EE+DT+E
Sbjct: 791 DAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYE 850
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
WALKSW+ CSK CGGG Q+TKYGCRR+ D+ MV R C+ K+PKPIRR CN C+ P+
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 910
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPA 968
WV EEW C+++CG G Q R ++CL PL +GT++ + +K C GDRPE+RRPC RVPCPA
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 970
Query: 969 QWKTGPWSECSVTCGEGTEVRQVLCRAG----DHCDGEKPESVRACQLPPC--------- 1015
QW+ G WS+CS TCGEG + RQV+CR HC+G++P++V+ C LP C
Sbjct: 971 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGNHQNSTV 1030
Query: 1016 ----------------------------NDEPCLGDKSIFCQMEVLARYCSIPGYNKLCC 1047
+ EPC GD+S+FCQMEVL RYCSIPGY++LCC
Sbjct: 1031 RADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPGYHRLCC 1090
Query: 1048 ESCSKRSS-----TLPPPYLLEAAETHDDVISNPSDLPRSLVMPTSLVPYHSETPAKKMS 1102
SC K++S P P L T + P D + P +
Sbjct: 1091 VSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQ 1150
Query: 1103 LSSISSVGGPNAYAAFRPNSKPDGAN 1128
L P F P + GA+
Sbjct: 1151 LPGALDTSSPGTQHPFAPETPIPGAS 1176
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 675 bits (1741), Expect = 0.0
Identities = 332/518 (64%), Positives = 387/518 (74%), Gaps = 40/518 (7%)
Query: 35 PIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNP---------------EQ 79
P+ E L PV T+ +GR +SH +SA+ + R + P
Sbjct: 49 PLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSH 108
Query: 80 LFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKT 139
LF+N+T FG+D HLRL+PN +LVAPGA +EW Q T R+
Sbjct: 109 LFYNVTVFGRDLHLRLRPNARLVAPGATMEW-----------------QGEKGTTRV--- 148
Query: 140 EPLQTNCAYVGDIVDIP-GTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEE-EKGRI 197
EPL +C YVGD+ + +SVA+SNCDGLAG+I+ + EE+FIEPLE+G +E E+GR+
Sbjct: 149 EPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV 208
Query: 198 HVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRR-RRHAGENDY 256
HVVY+R P+ + S L+ LD L G + + N + RR RRHA ++DY
Sbjct: 209 HVVYRRPPTSP-PLGGPQALDTGAS-LDSLDSLSRALGVLEEHANSSRRRARRHAADDDY 266
Query: 257 NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKS 316
NIEVLLGVDDSVV+FHGKEHVQ YLLTLMNIVNEIYHDESLG HINVVLVR+I+L Y KS
Sbjct: 267 NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKS 326
Query: 317 ISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMC 376
+SLIE GNPS+SLENVCRWA QQ+ D H E+HDHAIFLTRQDFGP+GMQGYAPVTGMC
Sbjct: 327 MSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMC 386
Query: 377 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRY 436
HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE +GS+MAPLVQAAFHR+
Sbjct: 387 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRF 446
Query: 437 HWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAF 496
HWSRCS QEL RY+HSYDCLLDDPF HDWP LP+LPG++YSM+EQCRFDFG+GY MCTAF
Sbjct: 447 HWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAF 506
Query: 497 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKW 534
RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGT CA GK+
Sbjct: 507 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKF 544
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 550 bits (1417), Expect = e-156
Identities = 344/1022 (33%), Positives = 508/1022 (49%), Gaps = 94/1022 (9%)
Query: 42 YELVTPVSTNLEGRYLSHTLSASHKKRSARDVSS-NPEQ----LFFNITAFGKDFHLRLK 96
Y+L P+ + G +LS T+ R R + +P+Q LFF ++A+GK FHL L
Sbjct: 42 YQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLT 101
Query: 97 PNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIP 156
NT V+ VE+ P H NC Y G + D
Sbjct: 102 LNTDFVSKHFTVEYWGKD-------GPQWKHD-------------FLDNCHYTGYLQDQR 141
Query: 157 GTS-VAISNCDGLAGMIKSDNEEYFIEPL----ERGKQMEEEKGRIHVVYKRSAVEQAPI 211
T+ VA+SNC GL G+I +++EEYFIEPL E K E G HV+YK+SA++Q +
Sbjct: 142 STTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHL 201
Query: 212 -DMS----KDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDD 266
D S DF R L+D TV ++ R++ + + +E L+ D
Sbjct: 202 YDHSHCGVSDF-TRSGKPWWLNDTSTVSYSLPINNTHIHHRQKRSVSIERFVETLVVADK 260
Query: 267 SVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPS 326
+V +HG++ +++Y+L++MNIV ++Y D SLG +N+++ R+I+L + +L +
Sbjct: 261 MMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLTEDQP-NLEINHHAD 319
Query: 327 RSLENVCRWASQQQRSDLNHSE-----------HHDHAIFLTRQDF-----GPAGMQGYA 370
+SL++ C+W Q+S L+H HHD+A+ +TR D P G G A
Sbjct: 320 KSLDSFCKW----QKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLA 375
Query: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE-TAMGSVMAPLV 429
V GMC P RSC++N + G SAF +AHE GH GM HDG GN CG + +MA +
Sbjct: 376 SVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHI 435
Query: 430 QAAFHRYHWSRCSGQELKRYIHS--YDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFG 487
A + + WS CS + ++ S CL ++P D+ PG Y DEQCRF +G
Sbjct: 436 TANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYG 495
Query: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGK----WCYKGHCMWK 543
+ C + + C++LWC N C T P +GT C G WCY+G C+
Sbjct: 496 ATSRQC---KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPF 550
Query: 544 NANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTE 603
Q DG WG W+ +G CSRTCG GV R C++P P GG+ C G Y+ CNT+
Sbjct: 551 GTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTD 610
Query: 604 ECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQL 663
C DFR +QC + + ++ ++W PY K C L C ++
Sbjct: 611 PCPLGSRDFREKQCADFD-NMPFRGKYYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPA 668
Query: 664 VHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTP 723
V DGT C+ D IC+ GEC VGCD +GS+ ED+C VCGGD S C ++G F +
Sbjct: 669 VIDGTQCN-ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSL 727
Query: 724 RKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVE 783
+ GY+++ IP G+ H+ ++E S + +A+K++ +YI NG R F G
Sbjct: 728 PRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYI-NGAWTIDWPRKFDVAGTA 786
Query: 784 WDY-NIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQE 842
+ Y D+ ESL GP + +IV+++ QE + + YK+ +VP + + E
Sbjct: 787 FHYKRPTDEPESLEALGPTSENLIVMVLLQEQNL--GIRYKF-----NVPITRTGSGDNE 839
Query: 843 ELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQ 902
F W + WS+CS C GG Q + C+R DN +V ++C+ + KP +R CN +
Sbjct: 840 V--GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTE 897
Query: 903 ECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
C P W +W C+KTC G + R V C++ + ++ C+ RP + PCN
Sbjct: 898 PCP-PEWFIGDWLECSKTC-DGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCN 955
Query: 963 RVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGD--------HCDGEKPESVR-ACQLP 1013
CP QW WSEC+ CG G + R VLC++ D C E VR C L
Sbjct: 956 NQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLG 1015
Query: 1014 PC 1015
C
Sbjct: 1016 RC 1017
Score = 51.6 bits (122), Expect = 4e-06
Identities = 25/64 (39%), Positives = 34/64 (53%), Gaps = 10/64 (15%)
Query: 970 WKTGPWSECSVTCGEGTEVRQVLCRAGD--------HCDGEK--PESVRACQLPPCNDEP 1019
W PWSECS TC G + ++V+C+ D +CD + PE+ RAC PC E
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 1020 CLGD 1023
+GD
Sbjct: 904 FIGD 907
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 535 bits (1377), Expect = e-151
Identities = 343/1034 (33%), Positives = 505/1034 (48%), Gaps = 104/1034 (10%)
Query: 41 EYELVTPVSTNLEGRYLSHT-LSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNT 99
+Y VTPV + G Y+SH L KKRSA++ S+ L + +AFG++ HL LKP+
Sbjct: 60 DYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSS---LHYRFSAFGQELHLELKPS- 115
Query: 100 QLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTS 159
A++ H V G D + Q +P C Y G I + +S
Sbjct: 116 ------AILSSHFIVQVLGK--DGASETQ-----------KPEVQQCFYQGFIRNDSSSS 156
Query: 160 VAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKG-----RIHVVYKRSAVEQ------ 208
VA+S C GL+G+I++ E+ I PL + E HV+YKR+A E+
Sbjct: 157 VAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRG 216
Query: 209 ------------------APIDMSKDFHYRESDLEGLDDLGTVYG------NIHQQLNE- 243
A ++H+R + Y + + + +E
Sbjct: 217 YPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEY 276
Query: 244 --TMRRRRHAGEND--YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGV 299
+ R RR AG++ N+E L+ D +V HGK +V Y+LT+MN+V+ ++ D ++G
Sbjct: 277 GSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGS 336
Query: 300 HINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQ 359
INVV+V +I+L LI + +SL + C+W S + + HDHAI LT
Sbjct: 337 DINVVVVSLILLEQEPGGLLINH-HADQSLNSFCQWQSALIGKN---GKRHDHAILLTGF 392
Query: 360 DF-----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNR 414
D P G+AP++GMC RSCT+N + G AF +AHE+GH GM HDG+GN
Sbjct: 393 DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNP 452
Query: 415 CGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYD--CLLDDPFDHDWPKLPE-L 471
C A G++M+P + + WS CS Q LK+++ + CL+D+P K P+ L
Sbjct: 453 C--RKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKL 510
Query: 472 PGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAA 531
PG Y D QC++ FG K+C+ D CK LWC + C+TK P +GT C
Sbjct: 511 PGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR--CETKFMPAAEGTVCGL 568
Query: 532 GKWCYKGHCM-WKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDC 590
WC +G C+ + + G W +W+K+ CSRTCG GV+F+ R CNNP P GG C
Sbjct: 569 SMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFC 628
Query: 591 PGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQ 650
PG + YQLCN C ++ DFRAQQC + NS ++ + W PY + + RC LYC+
Sbjct: 629 PGSSRIYQLCNINPCNENSLDFRAQQCAEYNSK-PFRGWFYQWKPYTKVEEEDRCKLYCK 687
Query: 651 SKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNS 710
++ M V DGT CS + +C+ G C VGCD E+GS V D CGVC GDNS
Sbjct: 688 AENFEFFFAMSGKVKDGTPCS-PNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNS 746
Query: 711 HCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGE 770
C+ KG + + Y + IP GAR + IQE + S LA+++ + +Y+ G
Sbjct: 747 TCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSI 806
Query: 771 EAKSRTFIDLGVEWDYNIE-DDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHED 829
+ F G ++Y + E L+ GP ++ ++ I+ Q + + +KY
Sbjct: 807 DWPGE-FPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKN--PGIAWKY----- 858
Query: 830 SVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEAN 889
++P + + + + W++ S+CS CGGG+ K C R N V+ SFC A
Sbjct: 859 ALPKVMNGTPPATKRPAYTWSIVQ-SECSVSCGGGYINVKAICLR-DQNTQVNSSFCSAK 916
Query: 890 KKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKY 949
KP ++CN C W+ EW C+K C + G Q R ++C+Q +V
Sbjct: 917 TKPVTEPKICNAFSCP-AYWMPGEWSTCSKAC-AGGQQSRKIQCVQKKPFQKEEAVLHSL 974
Query: 950 CMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAG-------DHCDG- 1001
C P + CN CP QW GPWS+CS TCG G R++LC+ C
Sbjct: 975 CPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSL 1034
Query: 1002 EKPESVRACQLPPC 1015
+PE C L C
Sbjct: 1035 PRPELQEGCVLGRC 1048
Score = 103 bits (257), Expect = 1e-21
Identities = 67/230 (29%), Positives = 105/230 (45%), Gaps = 27/230 (11%)
Query: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC--- 904
+W+L WSQCSK CG G + + C+ S + + S C + +P+ ++ C + C
Sbjct: 994 QWSLGPWSQCSKTCGRGVRKRELLCKG-SAAETLPESQCTSLPRPE-LQEGCVLGRCPKN 1051
Query: 905 THPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPES---RRPC 961
+ WVA W C+ TCG G + R ++C + G + + C + + C
Sbjct: 1052 SRLQWVASSWSECSATCGL-GVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
Query: 962 NRVPCPAQ--------WKTGPWSECSVTCGEGTEVRQVLC----RAGDHC-DGEKPESVR 1008
NR CPA W + PW +C+VTCG G + R V C R C +KP +R
Sbjct: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLR 1170
Query: 1009 ACQ-----LPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKR 1053
AC P ++P D +C + C+ Y K CC+SC+++
Sbjct: 1171 ACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRK 1220
Score = 31.6 bits (70), Expect = 4.8
Identities = 21/70 (30%), Positives = 29/70 (41%), Gaps = 13/70 (18%)
Query: 516 CKTKKGPPLDGTECAA------GKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGT 569
CK L ++C + + C G C KN+ Q +W CS TCG
Sbjct: 1018 CKGSAAETLPESQCTSLPRPELQEGCVLGRCP-KNSRLQWVASSWSE------CSATCGL 1070
Query: 570 GVRFRTRQCN 579
GVR R +C+
Sbjct: 1071 GVRKREMKCS 1080
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 512 bits (1319), Expect = e-145
Identities = 352/1141 (30%), Positives = 533/1141 (46%), Gaps = 129/1141 (11%)
Query: 3 LLSLWLIAAALVEVRTS-----ADGQAGNEEMVQIDLPIKR-----YREYELVTPVSTNL 52
L +LW++ A + E + A G+ + + P +R EY+LV+ +
Sbjct: 11 LAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEVDH 70
Query: 53 EGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHE 112
G Y+SH + ++R A VS E L + DFH+ L+ ++ LVAPG +V+
Sbjct: 71 RGDYVSHEIMHHQRRRRAVPVSE-VESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQ--- 126
Query: 113 TSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMI 172
G + +T P + C Y G + +SVA+S C GL+GMI
Sbjct: 127 ---------------TLGKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMI 171
Query: 173 KSDNEEYFIEPLERGKQMEEEKGRI-------HVVYKRSAVEQAP-----IDMSKDFHYR 220
+++ +YF+ PL + + GR HV+YKRS AP + S+ +
Sbjct: 172 RTEEADYFLRPLP--SHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELA 229
Query: 221 ESDLEGLD-------------------------DLGTVYGNIHQQLNETMRRRRHAGEND 255
L D DL + L R +
Sbjct: 230 HQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEE 289
Query: 256 YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAK 315
N+E L+ VD +++ HG E++ Y+LT++N+V+ ++ D ++G +IN+ +V +I+L +
Sbjct: 290 LNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQ 349
Query: 316 SISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF-----GPAGMQGYA 370
L+ + +L + C+W S D HDHAI LT D P G+A
Sbjct: 350 P-GLVISHHADHTLSSFCQWQSGLMGKD---GTRHDHAILLTGLDICSWKNEPCDTLGFA 405
Query: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQ 430
P++GMC RSCT+N + G AF +AHE+GH GM HDG+GN C + + G++M+P +
Sbjct: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC--KKSEGNIMSPTLA 463
Query: 431 AAFHRYHWSRCSGQELKRYIHSYD--CLLDDPFDHDWPKLPE-LPGINYSMDEQCRFDFG 487
+ WS CS Q L +++ + CL D P K PE LPG Y + QC++ FG
Sbjct: 464 GRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFG 523
Query: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCM-WKNAN 546
K+C D CK LWC C+TK P +GT C WC G C+ + +
Sbjct: 524 EKAKLCMLDFKKDICKALWCHRIGRK--CETKFMPAAEGTICGHDMWCRGGQCVKYGDEG 581
Query: 547 QQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQ 606
+ G+W W+ + CSRTCG GV R+R C NP P +GG+ C G +LCN+++C
Sbjct: 582 PKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCP 641
Query: 607 KHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHD 666
+ DFRA QC + NS ++ + W PY + + C LYC ++ + V D
Sbjct: 642 RDSVDFRAAQCAEHNSR-RFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKD 700
Query: 667 GTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKL 726
GT CS +D ++C+ G C +VGCD +GS+ VED CGVC G+NS C +G +T+
Sbjct: 701 GTPCS-EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTN 759
Query: 727 GYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDY 786
Y M IP GAR + I E S ++++N A Y LNG + G +DY
Sbjct: 760 QYYHMVTIPSGARSIRIYEMNVSTSYISVRN-ALRRYYLNGHWTVDWPGRYKFSGTTFDY 818
Query: 787 NIE-DDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELD 845
++ E+L GP ++ +IV ++ Q + + Y S+P + + +
Sbjct: 819 RRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEY-------SMPRLGTEKQPPAQ-P 870
Query: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNK-MVHRSFCEANKKPKPIRRM--CNIQ 902
++ WA+ S+CS CGGG + GC R D K V+ SFC N K +P+ + C +
Sbjct: 871 SYTWAIVR-SECSVSCGGGQMTVREGCYR--DLKFQVNMSFC--NPKTRPVTGLVPCKVS 925
Query: 903 ECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
C P W W C++TCG G Q R V+C + + + V + C P SR+ CN
Sbjct: 926 ACP-PSWSVGNWSACSRTCG-GGAQSRPVQCTR-RVHYDSEPVPASLCPQPAPSSRQACN 982
Query: 963 RVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH-----------CDGE-KPESVRAC 1010
CP W GPW+ECS TCG+G R V C++ + C E KP AC
Sbjct: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 1011 QLPPCNDEPCL-------GDKSIFCQMEVLARY--CSIPGYNKLCCESCSKRSSTLPPPY 1061
L C+ L S+ C+ R+ C+ + E SK+ S LP P
Sbjct: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Query: 1062 L 1062
L
Sbjct: 1103 L 1103
Score = 105 bits (262), Expect = 3e-22
Identities = 68/237 (28%), Positives = 102/237 (43%), Gaps = 38/237 (16%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDN---KMVHRSFCEANKKPKPIRRMCNIQECT 905
W+ W++CS CG G++ C+ + + +++ + C + KP+ + C +Q C
Sbjct: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR-MHEACLLQRCH 1048
Query: 906 HPL---WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRP--ESRR 959
P W+ W C+ TC G Q R ++C + + G R + SK C +P E R
Sbjct: 1049 KPKKLQWLVSAWSQCSVTC-ERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
Query: 960 PCNRVPCP------------AQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDG-----E 1002
C +PCP W PWS+C+ +CG G + R V C AG +
Sbjct: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
Query: 1003 KPESVRACQLPPCNDEPCLGDKSIFCQMEVLARY-------CSIPGYNKLCCESCSK 1052
KP + AC C P K FC+ Y CS Y K CC++CSK
Sbjct: 1168 KPSASLACNTHFC---PIAEKKDAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
Score = 30.8 bits (68), Expect = 8.1
Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 7/57 (12%)
Query: 555 GSW--TKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHF 609
GSW + + C+ +CG GV+ R+ QC + GG+ G + + C HF
Sbjct: 1128 GSWFASPWSQCTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHF 1179
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 497 bits (1280), Expect = e-140
Identities = 328/1009 (32%), Positives = 469/1009 (46%), Gaps = 94/1009 (9%)
Query: 43 ELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQ-LFFNITAFGKDFHLRLKPNTQL 101
++V PV + G +LS+ L ++ RDVS + F+ + G++ L N L
Sbjct: 44 DIVHPVRVDAGGSFLSYELWPRALRK--RDVSVRRDAPAFYELQYRGRELRFNLTANQHL 101
Query: 102 VAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVD--IPGTS 159
+APG V E + G IR P C +G++ D + G
Sbjct: 102 LAPGFVSE---------------TRRRGGLGRAHIRAHTPA---CHLLGEVQDPELEGGL 143
Query: 160 VAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQAPIDMSKDFHY 219
AIS CDGL G+ + NE+YFIEPL+ + HVVYKR A E+
Sbjct: 144 AAISACDGLKGVFQLSNEDYFIEPLDSAPARPGH-AQPHVVYKRQAPERLA--------- 193
Query: 220 RESDLEGLDDLGT-VYGNIH---------QQLNETMRRRRH--AGENDYNIEVLLGVDDS 267
+ D G VY + QQ RR H + + +E L+ D
Sbjct: 194 QRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAK 253
Query: 268 VVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSR 327
+V +HG+ V++Y+LT+MN+V ++HD S+G I++ +VR+++L + I +
Sbjct: 254 MVEYHGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITH-HADN 312
Query: 328 SLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF-----GPAGMQGYAPVTGMCHPVRSC 382
+L++ C+W H HHD AI LTR+D P G + V GMC P RSC
Sbjct: 313 TLKSFCKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSC 372
Query: 383 TLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCS 442
++N + G AF VAHE GH G++HDG GN C +M+P + WSRCS
Sbjct: 373 SINEDTGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCS 432
Query: 443 GQELKRYI-HSYDCLLDDPFDHDWPKLPELP-GINYSMDEQCRFDFGVGYKMCTAFRTFD 500
Q + R++ + LDDP D P +P G+ Y + QCR +G C
Sbjct: 433 RQYITRFLDRGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNV- 491
Query: 501 PCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKF 560
C LWCS C +K +DGT C KWC G C+ + DG W W+ +
Sbjct: 492 -CHTLWCSVGTT---CHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAW 547
Query: 561 GSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQR 620
CSR+CG GV+ RQC P P G+ C G ++LCN + C FR QC
Sbjct: 548 SICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQC--- 604
Query: 621 NSHFE---YQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHC-SYKDPY 676
SHF+ Y+ H W+P + C L+C+ ++ V DGT C +
Sbjct: 605 -SHFDAMLYKGQLHTWVPV--VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASR 661
Query: 677 SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPP 736
+C+ G C VGCD EI S +ED+CGVC G+ S C TV GTF LGY+ + IP
Sbjct: 662 DLCINGICKNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPA 720
Query: 737 GARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLH 796
GAR + IQE + + LA++++ Y LNG + + G + Y + E+L
Sbjct: 721 GAREIRIQEVAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNWENLT 780
Query: 797 TDGPLHDPVIVLIIPQENDTRSSLTYKYIIH-----EDSVPTINSNNVIQEELDTFEWAL 851
+ GP +PV + ++ QE++ + Y+Y IH D VP F W
Sbjct: 781 SPGPTKEPVWIQLLFQESN--PGVHYEYTIHREAGGHDEVPP-----------PVFSWHY 827
Query: 852 KSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVA 911
W++C+ CG G Q C + V C+ +P +R C+ Q C W A
Sbjct: 828 GPWTKCTVTCGRGVQRQNVYCLERQAGP-VDEEHCDPLGRPDDQQRKCSEQPCP-ARWWA 885
Query: 912 EEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNR-VPCPAQ 969
EW+ C+ +CG G R V C++ + ++ C RP + PCNR VPCPA
Sbjct: 886 GEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPAT 945
Query: 970 WKTGPWSECSVTCGEGTEVRQVLCR--AGDHCD-GEKPESVRACQLPPC 1015
W G WS+CSVTCGEGT+ R VLC G CD ++P S C LP C
Sbjct: 946 WAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPLC 994
Score = 114 bits (284), Expect = 7e-25
Identities = 76/226 (33%), Positives = 91/226 (40%), Gaps = 31/226 (13%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
W +WS+CS+ CGGG C D + + C+ P R C Q C
Sbjct: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS-- 1523
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPCP 967
W W C++ CG G Q R V C +P L C RP + RPCN PC
Sbjct: 1524 WYTSSWRECSEACG-GGEQQRLVTCPEPGL-----------CEEALRPNTTRPCNTHPC- 1570
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLC---------RAGDHCDGEK-PESVRACQLPPCND 1017
QW GPW +CS CG G + R V C D C E PES R C C
Sbjct: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEP 1630
Query: 1018 -EP--CLGDKSI--FCQMEVLARYCSIPGYNKLCCESCSKRSSTLP 1058
EP C D+ FC+ L C +P CC SCS S P
Sbjct: 1631 VEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAP 1676
Score = 62.4 bits (150), Expect = 3e-09
Identities = 42/122 (34%), Positives = 53/122 (43%), Gaps = 23/122 (18%)
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCM-GDRPESRRPCNRVPCP 967
W A W C+ TCG G R VRC S + C RP+ R C+ PC
Sbjct: 1415 WQAGNWSECSTTCGL-GAVWRPVRC---------SSGRDEDCAPAGRPQPARRCHLRPC- 1463
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLC--------RAGDHCDGEKPESVRACQLPPCNDEP 1019
A W +G WS+CS +CG G+ VR V C HC +P + PC +P
Sbjct: 1464 ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHC---QPGPAKPPAHRPCGAQP 1520
Query: 1020 CL 1021
CL
Sbjct: 1521 CL 1522
Score = 49.7 bits (117), Expect = 2e-05
Identities = 23/51 (45%), Positives = 27/51 (52%), Gaps = 3/51 (5%)
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAG---DHCDGEKPESVRACQLPPC 1015
A W+ G WSECS TCG G R V C +G D +P+ R C L PC
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPC 1463
Score = 36.2 bits (82), Expect = 0.19
Identities = 18/64 (28%), Positives = 30/64 (46%), Gaps = 14/64 (21%)
Query: 848 EWALKSWSQCSKPCGGGFQ-------YTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCN 900
+W + W QCS PCGGG Q T+ G + ++ H ++ E++ R C
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESS-------RPCG 1624
Query: 901 IQEC 904
++C
Sbjct: 1625 TEDC 1628
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 484 bits (1246), Expect = e-136
Identities = 313/999 (31%), Positives = 486/999 (48%), Gaps = 67/999 (6%)
Query: 36 IKRYREYELVTPVSTNLEGRYLSHTLSAS-HKKRSARDVSSNPEQLFFNITAFGKDFHLR 94
IK EY +V PV + G +LS+ L R RD+ + + +++ I+ KD
Sbjct: 46 IKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFN 105
Query: 95 LKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVD 154
L N ++ ++E +L S + + PL C G ++
Sbjct: 106 LTVNQGFLSNSYIMEKRYGNL---------------SHVKMMASSAPL---CHLSGTVLQ 147
Query: 155 IPGTSV---AISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHVVYKRSAVEQA-- 209
GT V A+S C GL G + + ++FIEP+++ + E H+VY+R V +
Sbjct: 148 -QGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKK-HPLVEGGYHPHIVYRRQKVPETKE 205
Query: 210 PIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVV 269
P KD ++ +L H + ++ RR + E +E L+ D ++
Sbjct: 206 PTCGLKD----SVNISQKQELWREKWERHNLPSRSLSRRSISKERW--VETLVVADTKMI 259
Query: 270 RFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSL 329
+HG E+V++Y+LT+MN+V ++H+ S+G I++V+VR+I+L + I + ++L
Sbjct: 260 EYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGLKIVH-HAEKTL 318
Query: 330 ENVCRWA-SQQQRSDLNHSEHHDHAIFLTRQDF-----GPAGMQGYAPVTGMCHPVRSCT 383
+ C+W S +SDLN HHD A+ LTR+D P G + ++GMC P RSC
Sbjct: 319 SSFCKWQKSINPKSDLN-PVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCN 377
Query: 384 LNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSG 443
+N + G AF +AHE GH G++HDG+ N C +M+ +Q WS+CS
Sbjct: 378 INEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSE 437
Query: 444 QELKRYIHSY--DCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDP 501
+ + R++ CL D P PG+ Y + QC+ +G C
Sbjct: 438 EYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENV-- 495
Query: 502 CKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFG 561
C+ LWCS FC++K DGT+C KWC G C+ + G WG W+ +
Sbjct: 496 CQTLWCSVKG---FCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWS 552
Query: 562 SCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRN 621
CSRTCG GV+ R CNNP P GG+ C G Y+LCN C+ FR QC + +
Sbjct: 553 HCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFD 612
Query: 622 SHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHC-SYKDPYSICV 680
+ Y+N +HW P +P C LYC+ + M V DGT C + ++C+
Sbjct: 613 T-VPYKNELYHWFPIF--NPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCI 669
Query: 681 RGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARH 740
G C VGCD EI SN ED+CGVC GD S C+TV+ F + GY+ + IP GAR
Sbjct: 670 NGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMF-KQKEGSGYVDIGLIPKGARD 728
Query: 741 VLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGP 800
+ + E E + + LAI+++ Y LNG + + G + Y+ + D+E L GP
Sbjct: 729 IRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMATGP 788
Query: 801 LHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKP 860
++ V + ++ Q T + Y+Y I +D + +N +++++ + W W++CS
Sbjct: 789 TNESVWIQLLFQV--TNPGIKYEYTIQKDGL-----DNDVEQQM--YFWQYGHWTECSVT 839
Query: 861 CGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKT 920
CG G + C +K MV +FC+ +P ++ C+ + C P W A EWE C+ T
Sbjct: 840 CGTGIRRQTAHCIKKG-RGMVKATFCDPETQPNGRQKKCHEKACP-PRWWAGEWEACSAT 897
Query: 921 CGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNR-VPCPAQWKTGPWSECS 979
CG G + RTV C+Q ++ + +P++ CNR + CP+ W G WSECS
Sbjct: 898 CGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECS 957
Query: 980 VTCGEGTEVRQVLCRAG--DHCD-GEKPESVRACQLPPC 1015
V+CG G +R V C + CD KP S C L C
Sbjct: 958 VSCGGGVRIRSVTCAKNHDEPCDVTRKPNSRALCGLQQC 996
Score = 103 bits (258), Expect = 8e-22
Identities = 69/225 (30%), Positives = 94/225 (41%), Gaps = 32/225 (14%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKK-PKPIRRMCNIQECTHP 907
W + +WS+CS+ C GGF+ + C D++ + C+ P P+ CN + C
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE-- 1425
Query: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCP 967
W E W C+++CG G Q R V C L D T R P S CN C
Sbjct: 1426 AWQVEPWSQCSRSCGG-GVQERGVFCPGGLCDWTKR-----------PTSTMSCNEHLC- 1472
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAGDH----------CDGE-KPESVRACQLPPCN 1016
W TG W CS +CG G + R V C + CD + +P + C C
Sbjct: 1473 CHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK 1532
Query: 1017 ---DEPCLGDK--SIFCQMEVLARYCSIPGYNKLCCESCSKRSST 1056
D C DK + FCQ + CS+P CC SC + T
Sbjct: 1533 KSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSCPQTHIT 1577
Score = 101 bits (252), Expect = 4e-21
Identities = 59/204 (28%), Positives = 96/204 (47%), Gaps = 19/204 (9%)
Query: 813 ENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGC 872
E D S +T ++++ + + + + + W + +WS+CS CG G + + C
Sbjct: 1287 EEDATSLITEGFLLNASNYKQLTNGH------GSAHWIVGNWSECSTTCGLGAYWRRVEC 1340
Query: 873 RRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVR 932
+ D S C A ++P P +R C+++ C W W C++ C S G+++R ++
Sbjct: 1341 STQMD------SDCAAIQRPDPAKR-CHLRPCAG--WKVGNWSKCSRNC-SGGFKIREIQ 1390
Query: 933 CLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVL 992
C+ R H ++ G P CN PC A W+ PWS+CS +CG G + R V
Sbjct: 1391 CVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVF 1449
Query: 993 CRAGDHCDGEK-PESVRACQLPPC 1015
C G CD K P S +C C
Sbjct: 1450 C-PGGLCDWTKRPTSTMSCNEHLC 1472
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 474 bits (1220), Expect = e-133
Identities = 318/1022 (31%), Positives = 475/1022 (46%), Gaps = 106/1022 (10%)
Query: 42 YELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNTQL 101
YE+ P + G L+ + ++R ++ +LF+ + + F L L +++L
Sbjct: 39 YEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAE-SRLFYKVASPSTHFLLNLTRSSRL 97
Query: 102 VAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTS-V 160
+A VE+ + G A R + +C Y G + TS V
Sbjct: 98 LAGHVSVEYWT---------------REGLAWQRAARP-----HCLYAGHLQGQASTSHV 137
Query: 161 AISNCDGLAGMIKSDNEEYFIEPLE---RGKQMEEEKGRIHVVYKRSAVEQAPIDMS--- 214
AIS C GL G+I +D EEY IEPL +G + EE G HVVYKRS++ +D +
Sbjct: 138 AISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGP-HVVYKRSSLRHPHLDTACGV 196
Query: 215 ---KDFHYRESDLEGLDD-----LGTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDD 266
K + R L L LG L ++ R R+ +E L+ D
Sbjct: 197 RDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERY-------VETLVVADK 249
Query: 267 SVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPS 326
+V +HG+ V+ Y+L +MNIV +++ D SLG +N+++ R+I+L + I +
Sbjct: 250 MMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPTLEITH-HAG 308
Query: 327 RSLENVCRWASQQQRSDLNHSEH-----------HDHAIFLTRQDF-----GPAGMQGYA 370
+SL++ C+W Q+S +NHS H HD A+ +TR D P G G A
Sbjct: 309 KSLDSFCKW----QKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGTLGLA 364
Query: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETA-MGSVMAPLV 429
PV GMC RSC++N + G ++AF +AHE GH GM HDG GN CG +MA +
Sbjct: 365 PVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAAHI 424
Query: 430 QAAFHRYHWSRCSGQELKRYIHSYD--CLLDDPFDHDWPKLPELPGINYSMDEQCRFDFG 487
+ + WS CS + ++ S CL + P D+ PG Y DEQCRF G
Sbjct: 425 TMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHG 484
Query: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGK----WCYKGHCMWK 543
V + C + + C +LWC N C T P +GT C WCYK C+
Sbjct: 485 VKSRQC---KYGEVCSELWCLSKSNR--CITNSIPAAEGTLCQTHTIDKGWCYKRVCVPF 539
Query: 544 NANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTE 603
+ + DG WG WT +G CSRTCG GV +R C++P P GG+ C G ++ CNT+
Sbjct: 540 GSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTD 599
Query: 604 ECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQL 663
+C +DFR QC + +S ++ + W Y K C L C ++
Sbjct: 600 DCPPGSQDFREVQCSEFDS-IPFRGKFYKWKTY-RGGGVKACSLTCLAEGFNFYTERAAA 657
Query: 664 VHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTP 723
V DGT C D ICV GEC VGCD+ +GS+ EDKC VCGGD S C T++G F+
Sbjct: 658 VVDGTPCR-PDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPAS 716
Query: 724 RKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVE 783
GY + IP G+ H+ IQ+ S LA+K +L G + G
Sbjct: 717 PGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQES-LLLEGLPGTPQPHRLPLAGTT 775
Query: 784 WDYNI-EDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQE 842
+ D ++SL GP++ +IV+++ + +L Y++ + + ++
Sbjct: 776 FQLRQGPDQVQSLEALGPINASLIVMVLARTE--LPALRYRF-----------NAPIARD 822
Query: 843 ELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQ 902
L + W W++CS C GG Q CR + D+ V +C A+ K +R CN +
Sbjct: 823 SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTE 882
Query: 903 ECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
C P WV W C+++C +G + R+V C + + +++ C RP C+
Sbjct: 883 PCP-PDWVVGNWSLCSRSC-DAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACH 940
Query: 963 RVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH---------CDGEKPESVRACQLP 1013
CP +W WSEC+ +CG G R VLC++ DH KP + C L
Sbjct: 941 GPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLR 1000
Query: 1014 PC 1015
C
Sbjct: 1001 RC 1002
Score = 43.9 bits (102), Expect = 0.001
Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 10/70 (14%)
Query: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCR--------AGDHCDGEK--PESVRACQLPPCN 1016
P W PW++CS C G++V+ V CR A +C P+ RAC PC
Sbjct: 826 PYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP 885
Query: 1017 DEPCLGDKSI 1026
+ +G+ S+
Sbjct: 886 PDWVVGNWSL 895
Score = 30.8 bits (68), Expect = 8.1
Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 26/117 (22%)
Query: 516 CKTKKGPPLDGTECAAGKWCYKGHCMWK-NANQQKQDGNWGSWTKFGSCSRTCGTGVRFR 574
C ++ PP AG+W G C + Q+++ S T G S C +R
Sbjct: 997 CNLRRCPP---ARWVAGEW---GECSAQCGVGQRQRSVRCTSHT--GQASHECTEALRPP 1048
Query: 575 TRQ-----CNNPMPINGGQDCPGVN--------FEYQLCNTEECQKHFEDFRAQQCQ 618
T Q C++P P +G ++C VN ++Q C+ + +F + CQ
Sbjct: 1049 TTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCS----RAYFRQMCCKTCQ 1101
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 469 bits (1206), Expect = e-132
Identities = 342/1104 (30%), Positives = 516/1104 (46%), Gaps = 171/1104 (15%)
Query: 41 EYELVTPVSTNLEGRYLSHTLSASHKKRSARDV------------SSNPEQLFFNITAFG 88
EYE+V+P+ N G + +RS SS Q + ++AFG
Sbjct: 47 EYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFG 106
Query: 89 KDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQT-NCA 147
+ F L N +AP V T PG + E + +C
Sbjct: 107 QQFLFNLTANAGFIAPLFTVTLLGT---------------PGVNQTKFYSEEEAELKHCF 151
Query: 148 YVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQME--EEKGRIHVVYKRSA 205
Y G + + IS C G+ G +S + +YFIEPL+ + E EE+ + H++Y+RSA
Sbjct: 152 YKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSA 211
Query: 206 VEQAP------IDMS--KDFHYRES----------------DLEGLD-----DLGTVYGN 236
++ P D S K+ H ++ D+ L+ + + YGN
Sbjct: 212 PQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGN 271
Query: 237 IHQQLNETMRRRRHAGENDYN--IEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHD 294
E RR Y +EVL+ D+ +V +HG E++Q+Y+LTLM+IV IY D
Sbjct: 272 KTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKD 330
Query: 295 ESLGVHINVVLVRMIMLGYAK---SISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHD 351
S+G IN+V+V +I++ + SIS N +L+N C+W Q + HHD
Sbjct: 331 PSIGNLINIVIVNLIVIHNEQDGPSISF----NAQTTLKNFCQW---QHSKNSPGGIHHD 383
Query: 352 HAIFLTRQDFGPAGMQ----GYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGME 407
A+ LTRQD A + G A + +C P RSC+++ + G S+AF +AHE GHV M
Sbjct: 384 TAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMP 443
Query: 408 HDGQGNRCGDETAMGS--VMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDH 463
HD N+C +E VMAP + + + WS+CS + + ++ + +CLL++P
Sbjct: 444 HD-DNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR 502
Query: 464 DWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGP 522
+P +LPGI Y++++QC FG G ++C C++LWC++ + + C+T+ P
Sbjct: 503 PYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTP 559
Query: 523 PLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPM 582
DGTEC GK C G C+ K + DG+WGSW+ FG+CSRTCG G++ R+CN P
Sbjct: 560 WADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPE 619
Query: 583 PINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQ-RNSHFEYQN--TKHHWLP-YEH 638
P NGG+ C G +++ CNTE C K DFR +QC HF W+P Y
Sbjct: 620 PKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSG 679
Query: 639 PDPKKRCHLYCQSKETGDVAY--MKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSN 696
K RC L+C + G+ AY ++ V DGT C +D ICV+G C + GCD + S
Sbjct: 680 ILMKDRCKLFC--RVAGNTAYYQLRDRVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSK 736
Query: 697 KVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEAS-----PH 751
DKCGVCGGDNS C+TV GTF GY + IP GA ++ +++ S +
Sbjct: 737 ARRDKCGVCGGDNSSCKTVAGTFNTV--HYGYNTVVRIPAGATNIDVRQHSFSGETDDDN 794
Query: 752 ILAIKNQATGHYILNGKGEEAKSRTFIDLG---VEWDYNIEDDIESLHTDGPLHDPVIVL 808
LA+ + + G ++LNG ++ I +G VE+ E +E +++ + +++
Sbjct: 795 YLAL-SSSKGEFLLNGNFVVTMAKREIRIGNAVVEYS-GSETAVERINSTDRIEQELLLQ 852
Query: 809 IIPQENDTRSSLTYKYIIHEDSVP----------------------------TINSNNV- 839
++ + Y + I + P T S+ +
Sbjct: 853 VLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLT 912
Query: 840 --------------IQEELDT---FEWALKSWSQCSKPCGGGFQYTKYGCRRKS----DN 878
I E T W + S S+CS CG G++ C + S
Sbjct: 913 VSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKT 972
Query: 879 KMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLL 938
+ V FC ++ PKP R EC W W C+K+C G Q R C +
Sbjct: 973 EKVDDGFCSSH--PKPSNREKCSGECNTGGWRYSAWTECSKSC-DGGTQRRRAIC----V 1025
Query: 939 DGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH 998
+ N + C + + C+ PCP QWK+G WSEC VTCG+G + RQV C+ G+
Sbjct: 1026 NTRNDVLDDSKCTHQEKVTIQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQVWCQFGED 1084
Query: 999 ------CDGE-KPESVRACQLPPC 1015
CD E KP S++ CQ P C
Sbjct: 1085 RLNDRMCDPETKPTSMQTCQQPEC 1108
Score = 116 bits (290), Expect = 1e-25
Identities = 67/183 (36%), Positives = 86/183 (46%), Gaps = 22/183 (12%)
Query: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
+W +WSQCS CG G Q GC+ + +K+ + C +P+ R C C
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGT-HKIARETECNPYTRPES-ERDCQGPRCPLY 1557
Query: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966
W AEEW+ CTKTCG G + R V C+ D VH C + RP R C+ PC
Sbjct: 1558 TWRAEEWQECTKTCGE-GSRYRKVVCV----DDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Query: 967 PAQWKTGPWSECSVTCGEGTEVRQVLC--------------RAGDHCDGEKPESVRACQL 1012
W TG WSECSVTCG+G + R V C + +C G +P SV C L
Sbjct: 1613 EYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
Query: 1013 PPC 1015
C
Sbjct: 1673 RDC 1675
Score = 107 bits (266), Expect = 9e-23
Identities = 61/178 (34%), Positives = 88/178 (49%), Gaps = 19/178 (10%)
Query: 847 FEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
+ W + W +C+K CG G +Y K C + N+ VH + C+ +K+P R C++Q C +
Sbjct: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNE-VHGARCDVSKRPVD-RESCSLQPCEY 1614
Query: 907 PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKY----CMGDRPESRRPCN 962
+W+ EW C+ TCG GY+ R V C + + G +S C G +P S PC
Sbjct: 1615 -VWITGEWSECSVTCGK-GYKQRLVSCSE-IYTGKENYEYSYQTTINCPGTQPPSVHPCY 1671
Query: 963 RVPCP--AQWKTGPWSECSVTCGEGTEVRQVLCRAGD-------HCDGEKPESVRACQ 1011
CP A W+ G W CSV+CG G R V C + H D KPE + C+
Sbjct: 1672 LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTD-LKPEERKTCR 1728
Score = 95.9 bits (237), Expect = 2e-19
Identities = 61/203 (30%), Positives = 95/203 (46%), Gaps = 28/203 (13%)
Query: 830 SVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEAN 889
S P ++ E +T W +W++CSK C GG Q + C + N ++ S C
Sbjct: 982 SHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVN-TRNDVLDDSKCTHQ 1040
Query: 890 KKPKPIRRMCNIQECTH---PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVH 946
+K IQ C+ P W + +W C TCG G++ R V C G +R ++
Sbjct: 1041 EK-------VTIQRCSEFPCPQWKSGDWSECLVTCGK-GHKHRQVWCQF----GEDR-LN 1087
Query: 947 SKYCMGD-RPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCD----- 1000
+ C + +P S + C + C A W+ GPW +CSVTCG+G ++R V C G +
Sbjct: 1088 DRMCDPETKPTSMQTCQQPEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDN 1146
Query: 1001 ----GEKPESVRACQLPPCNDEP 1019
+P + C+LP C+ P
Sbjct: 1147 DCNAATRPTDTQDCELPSCHPPP 1169
Score = 93.2 bits (230), Expect = 1e-18
Identities = 60/177 (33%), Positives = 78/177 (44%), Gaps = 19/177 (10%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
W+ WS CS CG G + C K D + +C+ KP R+ C C P
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAK-DGSHLESDYCKHLAKPHGHRK-CRGGRC--PK 1500
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCP 967
W A W C+ +CG G Q R V C GT++ C RPES R C CP
Sbjct: 1501 WKAGAWSQCSVSCG-RGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Query: 968 A-QWKTGPWSECSVTCGEGTEVRQVLC-------RAGDHCD-GEKPESVRACQLPPC 1015
W+ W EC+ TCGEG+ R+V+C G CD ++P +C L PC
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 92.0 bits (227), Expect = 3e-18
Identities = 126/488 (25%), Positives = 168/488 (34%), Gaps = 112/488 (22%)
Query: 547 QQKQDGNW--GSWTKFGSCSRTCGTGVRFRTRQC--NNPMPINGGQDCPGVNFEYQLCNT 602
QQ + +W G W G CS TCG G + R +C M + DC N + +T
Sbjct: 1104 QQPECASWQAGPW---GQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC---NAATRPTDT 1157
Query: 603 EECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQ 662
++C+ LP HP P + ET Y
Sbjct: 1158 QDCE---------------------------LPSCHPPPA--------APETRRSTYSAP 1182
Query: 663 LVH----DGTHCSYKDPYSICVRGECVK-VGCDKEIGSNKVEDKCGVCGGDNSHCRTVKG 717
T CS + C +G ++ V C E GS D S C T+
Sbjct: 1183 RTQWRFGSWTPCS-----ATCGKGTRMRYVSCRDENGSV----------ADESACATL-- 1225
Query: 718 TFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTF 777
PR + + P G L D +S + + +AT + + R+
Sbjct: 1226 -----PRPVAKEECSVTPCGQWKAL---DWSSCSVTCGQGRATRQVMCVNYSDHVIDRSE 1277
Query: 778 IDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSN 837
D DY E D + + P P S L +ED P S
Sbjct: 1278 CDQ----DYIPETDQDCSMSPCPQRTP------------DSGLAQHPFQNEDYRPRSASP 1321
Query: 838 NVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR 897
+ L +W W CS C GG Q C+ D + C KP +R
Sbjct: 1322 SRTHV-LGGNQWRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIKPDE-QR 1376
Query: 898 MCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPES 957
C C P W W CTK CG G + R V C + R + D+P
Sbjct: 1377 ACESGPC--PQWAYGNWGECTKLCGG-GIRTRLVVCQR---SNGERFPDLSCEILDKPPD 1430
Query: 958 RRPCNRVPCP--AQWKTGPWSECSVTCGEGTEVRQVLCRA--GDHCDGE------KPESV 1007
R CN CP A W TGPWS CSV+CG G + R V C A G H + + KP
Sbjct: 1431 REQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGH 1490
Query: 1008 RACQLPPC 1015
R C+ C
Sbjct: 1491 RKCRGGRC 1498
Score = 35.0 bits (79), Expect = 0.43
Identities = 28/98 (28%), Positives = 41/98 (41%), Gaps = 16/98 (16%)
Query: 481 QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC 540
+C G GYK + C +++ + Y +T P GT+ + CY C
Sbjct: 1623 ECSVTCGKGYK-----QRLVSCSEIYTGKENYEYSYQTTINCP--GTQPPSVHPCYLRDC 1675
Query: 541 MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQC 578
+ + GNWGS CS +CG GV R+ QC
Sbjct: 1676 P---VSATWRVGNWGS------CSVSCGVGVMQRSVQC 1704
Score = 34.7 bits (78), Expect = 0.56
Identities = 19/54 (35%), Positives = 24/54 (44%)
Query: 974 PWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIF 1027
P+ CS TCG G + C + +G K R + CN EPCL K F
Sbjct: 596 PFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDF 649
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 456 bits (1173), Expect = e-128
Identities = 317/1079 (29%), Positives = 490/1079 (45%), Gaps = 134/1079 (12%)
Query: 36 IKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRL 95
++ YE+V P N G + S +KRS+ + P + + TA+G+ F L L
Sbjct: 34 VRTLTSYEVVIPERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNL 93
Query: 96 KPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDI 155
+ +A G T + G G + R +C Y G +
Sbjct: 94 TADASFLAAGY------TEVHLGTPERGAWESDAGPSDLR---------HCFYRGQVNSQ 138
Query: 156 PGTSVAISNCDGLAGMIKSDNEEYFIEPLER--GKQMEEEKGRIHVVYKRSAVEQAPIDM 213
+S C GL G K N EYF+EP+ + G + E+ + H++Y++ + + +
Sbjct: 139 EDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQD-LNNSFLQT 197
Query: 214 SKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRR--------------RRHAGENDY--- 256
K ES ++ Y N+++ LN R RRH+ +
Sbjct: 198 LKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISY 257
Query: 257 --NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYA 314
IE+++ D VV HG ++QNY+LTLM+IV IY D S+G I++V+V+++M+
Sbjct: 258 PRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHRE 316
Query: 315 KSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPA----GMQGYA 370
+ +I + +L+N C W Q D H HHD A+ +TR+D + M G +
Sbjct: 317 EEGPVINFDGAT-TLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLS 375
Query: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGD-ETAMGSVMAPLV 429
+ +C P++SC +N E G SAF +AHE GH LG++HD RC + + VMAP +
Sbjct: 376 YLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVMAPAL 434
Query: 430 QAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFG 487
+ WS CS + + ++ + +CLLD P + + ELPG Y ++QC FG
Sbjct: 435 SFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFG 494
Query: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAAGKWCYKGHCMWKNAN 546
G +MC C LWC+ + + C T+ PP DGT+C G C G C+ K
Sbjct: 495 PGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETE 551
Query: 547 QQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQ 606
+ +G WG W + SCSRTCG G+ TR+CN P P NGG C G +++ CNT+ C
Sbjct: 552 TRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCP 611
Query: 607 KHFEDFRAQQCQQRN-SHFEYQN--TKHHWLP-YEHPDPKKRCHLYCQSKETGDVAYMKQ 662
K +DFR +QC N H + + WLP Y K RC LYCQ T +K
Sbjct: 612 KGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKD 671
Query: 663 LVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRT 722
+V DGT C + + ICV+G+C+ GCD + S+ DKCGVCGGDNS C+T+ G F +
Sbjct: 672 MVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSS 730
Query: 723 PRKLGYLKMFDIPPGARHVLIQE----DEASPHILAIKNQATGHYILNGKGEEAKSRTFI 778
GY + IP GA +V I++ + LA+ + A G+++ NG + S+ I
Sbjct: 731 --HYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLAL-SDAEGNFLFNGNFLLSTSKKEI 787
Query: 779 DLG-----VEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKY--------- 824
++ +E+ + +E +++ +I+ ++ N + Y +
Sbjct: 788 NVQGTRTVIEYS-GSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSD 846
Query: 825 --------------------------IIHEDSVPTINSNNVIQEELDTF----------- 847
IH+ ++ L +F
Sbjct: 847 MFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCEL 906
Query: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNK----MVHRSFCEANKKPKPIRRMCNIQE 903
W + S+CS CG G++ C + S ++ V +C KP P + +C+
Sbjct: 907 RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKP-PTQELCH-GN 964
Query: 904 CTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNR 963
C W EW C+++CG G + R C ++ + C +R CN
Sbjct: 965 CVFTRWHYSEWSQCSRSCG-GGERSRESYC----MNNFGHRLADNECQELSRVTRENCNE 1019
Query: 964 VPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAG-DH-CDG-----EKPESVRACQLPPC 1015
CP+ W WSEC VTCG+GT+ RQV C+ DH DG KPES+ C+L C
Sbjct: 1020 FSCPS-WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
Score = 95.1 bits (235), Expect = 4e-19
Identities = 58/180 (32%), Positives = 78/180 (43%), Gaps = 26/180 (14%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
W WSQCS+ CGGG + + C +++ E + + R CN C P
Sbjct: 970 WHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADN---ECQELSRVTRENCNEFSC--PS 1024
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRC---LQPLLDGTNRSVHSKYCMGDRPESRRPCNRVP 965
W A EW C TCG G + R V C + L DG S +PES PC
Sbjct: 1025 WAASEWSECLVTCG-KGTKQRQVWCQLNVDHLSDGFCNS-------STKPESLSPCELHT 1076
Query: 966 CPAQWKTGPWSECSVTCGEGTEVRQVLC--------RAGDHC-DGEKPESVRACQLPPCN 1016
C A W+ GPW C+ TCG G ++R V C C + +P ++C L PC+
Sbjct: 1077 C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135
Score = 94.7 bits (234), Expect = 5e-19
Identities = 71/241 (29%), Positives = 103/241 (42%), Gaps = 32/241 (13%)
Query: 835 NSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKP 894
N N V+ + +W W CS C GG Q+ C+ D S+C+A KP P
Sbjct: 1294 NENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ---DENGQSASYCDAASKP-P 1349
Query: 895 IRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQP---LLDGTNRSVHSKYCM 951
+ C C P W W C++TCG G + R V C P +L+ N + +K
Sbjct: 1350 ELQQCGPGPC--PQWNYGNWGECSQTCG-GGIKSRLVICQFPNGQILEDHNCEIVNK--- 1403
Query: 952 GDRPESRRPCNRVPCPA--QWKTGPWSECSVTCGEGTEVRQVLC-------RAGDHCDG- 1001
P S C+ CPA W PW+ CS +CG+G + R+V C +C
Sbjct: 1404 ---PPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQV 1460
Query: 1002 EKPESVRACQLPPCND--EPCLGDKSIFCQMEVLAR--YCSIPGYNKLCCESCSKRSSTL 1057
+KP + +AC+ C + S+ C V R YC + G ++ E C + ST
Sbjct: 1461 QKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQ--STR 1518
Query: 1058 P 1058
P
Sbjct: 1519 P 1519
Score = 94.0 bits (232), Expect = 8e-19
Identities = 55/179 (30%), Positives = 77/179 (43%), Gaps = 29/179 (16%)
Query: 837 NNVIQEELDTFE---WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPK 893
+ V +E + F WA WS+C CG G + + C+ D+ + FC ++ KP+
Sbjct: 1010 SRVTRENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPE 1067
Query: 894 PIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGD 953
+ C + C W W CT TCG GYQ+R V+C+ L
Sbjct: 1068 SLSP-CELHTCAS--WQVGPWGPCTTTCGH-GYQMRDVKCVNELASAVLEDTECHEA--S 1121
Query: 954 RPESRRPCNRVPCP------------------AQWKTGPWSECSVTCGEGTEVRQVLCR 994
RP R+ C PC AQW+ G W+ CSV+CG GT+ R V CR
Sbjct: 1122 RPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCR 1180
Score = 94.0 bits (232), Expect = 8e-19
Identities = 58/186 (31%), Positives = 86/186 (46%), Gaps = 17/186 (9%)
Query: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
+W +W +CS+ CGGG + C+ + + + NK P I+ C++ C
Sbjct: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ--CHMHACPAD 1418
Query: 908 L-WVAEEWEHCTKTCGSSGYQLRTVRCL---QPLLDGTNRSVHSKYCMGDRPESRRPCNR 963
+ W E W C+ +CG G + R V C+ Q L+ TN S K P + + C
Sbjct: 1419 VSWHQEPWTSCSASCGK-GRKYREVFCIDQFQRKLEDTNCSQVQK------PPTHKACRS 1471
Query: 964 VPCPAQWKTGPWSECSVTCGEGTEVRQVLCR---AGDHCDGEKPESVRACQLPPCNDEPC 1020
V CP+ WK W+ECSVTCG G + R V CR G + +S R C C + C
Sbjct: 1472 VRCPS-WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
Query: 1021 LGDKSI 1026
+ K +
Sbjct: 1531 VQHKGM 1536
Score = 74.7 bits (182), Expect = 5e-13
Identities = 55/218 (25%), Positives = 81/218 (37%), Gaps = 63/218 (28%)
Query: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
+W SW+ CS CG G Q CR D ++ S+C +P I +C P
Sbjct: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDALD-RIADESYCAHLPRP------AEIWDCFTP 1207
Query: 908 L--WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGD-RPESRRPCNRV 964
W A +W C+ +CG G R V C+ ++ + YC + RP + C+
Sbjct: 1208 CGEWQAGDWSPCSASCGH-GKTTRQVLCMN-----YHQPIDENYCDPEVRPLMEQECSLA 1261
Query: 965 PCPA-----------------------------------------QWKTGPWSECSVTCG 983
CP QW+TGPW CS +C
Sbjct: 1262 ACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCS 1321
Query: 984 EGTEVRQVLC-----RAGDHCD-GEKPESVRACQLPPC 1015
G + R V+C ++ +CD KP ++ C PC
Sbjct: 1322 GGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC 1359
Score = 74.3 bits (181), Expect = 6e-13
Identities = 53/192 (27%), Positives = 75/192 (39%), Gaps = 33/192 (17%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTH-- 906
W + W C+ CG G+Q C + + ++ + C +P R+ C + C+
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFIS 1138
Query: 907 ---------------PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCM 951
W W C+ +CG G Q R V C D +R YC
Sbjct: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSCR----DALDRIADESYCA 1193
Query: 952 G-DRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR------AGDHCDGE-K 1003
RP C PC +W+ G WS CS +CG G RQVLC ++CD E +
Sbjct: 1194 HLPRPAEIWDCF-TPC-GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
Query: 1004 PESVRACQLPPC 1015
P + C L C
Sbjct: 1252 PLMEQECSLAAC 1263
Score = 59.7 bits (143), Expect = 2e-08
Identities = 58/235 (24%), Positives = 80/235 (34%), Gaps = 70/235 (29%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
W SW++CS CG G Q CR K ++V C+ + +P RR C Q+C
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEE-MCDQSTRPCSQRR-CWSQDCVQHK 1534
Query: 909 WVAEEWEHCTKTC------------------------GSSGYQLRTVRCLQPLLDGTNRS 944
+ +C+ +C SS L + C P + +
Sbjct: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT 1594
Query: 945 VHSKYCMGDRPESRRP----CNRVP-----------------CP---------------- 967
S C + S R C +P CP
Sbjct: 1595 ADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLH 1654
Query: 968 -AQWKTGPWSECSVTCGEGTEVRQVLC-----RAGDHC-DGEKPESVRACQLPPC 1015
A WK G WS+CSVTCG G RQV C + D C + KP + + C C
Sbjct: 1655 LATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 31.6 bits (70), Expect = 4.8
Identities = 13/29 (44%), Positives = 18/29 (62%), Gaps = 3/29 (10%)
Query: 553 NWGSWTKFGSCSRTCGTGVRFRTRQCNNP 581
N+G+W G CS+TCG G++ R C P
Sbjct: 1363 NYGNW---GECSQTCGGGIKSRLVICQFP 1388
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 436 bits (1121), Expect = e-122
Identities = 310/1090 (28%), Positives = 487/1090 (44%), Gaps = 158/1090 (14%)
Query: 70 ARDVSSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQP 129
A+ + +++ I AF +D +L L+ + + +AP VE P P
Sbjct: 155 AQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQR-----------PNPGPGP 203
Query: 130 GSATYRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDG-LAGMIKSDNEEYFIEPLERGK 188
A + P C Y G ++ PG+ + S C G L G I+ + + FIEPL
Sbjct: 204 TGAASAPQPPAPPDAGCFYTGAVLRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTM 263
Query: 189 QMEEEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRR 248
+ G H VY++ + + H + + D G +++ E+ R +
Sbjct: 264 AIT---GHPHRVYRQKRSMEEKVTEKSALHSHYCGI--ISDKGRPRS---RKIAESGRGK 315
Query: 249 RHAGE--NDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLV 306
R++ + +YNIE ++ D ++V +HG + + ++LT++N+V ++ +SL V +N+ ++
Sbjct: 316 RYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVI 375
Query: 307 RMIMLGYAKSISLIERGNPSRSLENVCRWASQQ--QRSDLNHSEHH----------DHAI 354
++I+L + L + + LE+ C+W ++ +++D+ H E D AI
Sbjct: 376 KLILL-HETPPELYIGHHGEKMLESFCKWQHEEFGKKNDI-HLEMSTNWGEDMTSVDAAI 433
Query: 355 FLTRQDF-----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHD 409
+TR+DF P G A ++GMC R C + ++G + AF +AHE GH +G+ HD
Sbjct: 434 LITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHD 493
Query: 410 GQGNRCGD-------ETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLD-D 459
C D E G + + WSRCS ++L+R++ S +CLL +
Sbjct: 494 NDHPSCADGLHIMSGEWIKGQNLGDV--------SWSRCSKEDLERFLRSKASNCLLQTN 545
Query: 460 PFDHDWPKLP-ELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKT 518
P + +P +LPG+ Y+ DEQC+ FG C + C LWC + C+T
Sbjct: 546 PQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVI-CTGLWCK-VEGEKECRT 603
Query: 519 KKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQC 578
K PP+DGT+C GKWC G C + + + G W W+ CSRTC G+ R R+C
Sbjct: 604 KLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC 660
Query: 579 NNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEH 638
P + +DC G +Y++C C FR QCQ ++ ++ H L ++
Sbjct: 661 --PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQ---AYSVRTSSPKHILQWQA 715
Query: 639 P-DPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNK 697
D +K C L+C + + V DGT C Y+ IC G C KVGCD +GS
Sbjct: 716 VLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQG-LDICANGRCQKVGCDGLLGSLA 774
Query: 698 VEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKN 757
ED CGVC G+ C+ +KG F T R GY+++ IP GAR + + E++ + LA+++
Sbjct: 775 REDHCGVCNGNGKSCKIIKGDFNHT-RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALRD 833
Query: 758 QATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTR 817
G +N + S F G Y E + GP P+ +L++ + D
Sbjct: 834 --AGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQ-DQN 890
Query: 818 SSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRR--K 875
L Y+Y I D +P N ++ E L F W SW C CGGG + T C +
Sbjct: 891 YGLHYEYTIPSDPLPE-NQSSKAPEPL--FMWTHTSWEDCDATCGGGERKTTVSCTKIMS 947
Query: 876 SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQ 935
+ +V C+ KP+P R CN Q C W+ EW C++TCG G Q R V C Q
Sbjct: 948 KNISIVDNEKCKYLTKPEPQIRKCNEQPC-QTRWMMTEWTPCSRTCGK-GMQSRQVACTQ 1005
Query: 936 PLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC-- 993
L +GT + C+G +P S + C C W+ G WSECSV CG+G R V C
Sbjct: 1006 QLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTN 1065
Query: 994 -----------RAGDHCD------------------------------------------ 1000
R + C+
Sbjct: 1066 PRKKCVLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE 1125
Query: 1001 ---GEKPESVRACQLPPCNDE----------------PCLGDK-SIFCQMEVLARYCSIP 1040
EKP + R C L PCN++ CLGD+ ++C++ C
Sbjct: 1126 CFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKCLGDQWPVYCRVIREKNLCQDM 1185
Query: 1041 GYNKLCCESC 1050
+ + CCE+C
Sbjct: 1186 RWYQRCCETC 1195
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 426 bits (1096), Expect = e-119
Identities = 298/972 (30%), Positives = 447/972 (45%), Gaps = 124/972 (12%)
Query: 80 LFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKT 139
L ++ AFG+D +L+L+ + + ++ G VE + G+A R R
Sbjct: 81 LLLHLPAFGRDLYLQLRRDLRFLSRGFEVE------------------EAGAARRRGRPA 122
Query: 140 EPLQTNCAYVGDIVDIPGTSVAISNCD---GLAGMIKSDNEEYFIEPLERGKQMEEEKGR 196
E C Y G ++ PG+ V++S C GL G+I+ E+ I+PL + GR
Sbjct: 123 EL----CFYSGRVLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQG--PFSGR 176
Query: 197 IHVVYKR-------SAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRR 249
H++ ++ SA Q P + K ++ G + + R RR
Sbjct: 177 EHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWG-------------RPSRDWRERR 223
Query: 250 HAGE--NDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVR 307
+A +++ +E L+ D +V++HG E Q ++LT+MN+V ++ +SLG+ IN+ + +
Sbjct: 224 NAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTK 283
Query: 308 MIMLGYAKS-ISLIERGNPSRSLENVCRWASQQQRSDLNHSEHH-----------DHAIF 355
+++L + +S+ G RSLE+ C W +++ + D A+F
Sbjct: 284 LVLLRQRPAKLSIGHHGE--RSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAAVF 341
Query: 356 LTRQDF-----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 410
+TR DF P G A + G+C R C L ++G + AF +AHE GH LGM HD
Sbjct: 342 VTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDD 401
Query: 411 QGNRCGDETAMGSVMAPLVQAAFHR-YHWSRCSGQELKRYIHSY--DCLL-DDPFDHDWP 466
+ C + + S V+ WS CS +L+ ++ S CLL DP
Sbjct: 402 DHSSCAGRSHIMS--GEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTV 459
Query: 467 KLP-ELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLD 525
+LP +LPG++YS +EQC+ FG+ C C LWC + CKTK PPLD
Sbjct: 460 RLPHKLPGMHYSANEQCQILFGMNATFCRNMEHL-MCAGLWCL-VEGDTSCKTKLDPPLD 517
Query: 526 GTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPIN 585
GTEC A KWC G C+ K + DG+W W + CSRTCGTG RFR R+C+NP P
Sbjct: 518 GTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGP 577
Query: 586 GGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRC 645
GG CPG + E+ +C C K FR QQCQ +H K L D K C
Sbjct: 578 GGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQ---AHDRLSPKKKGLLTAVVVDDKP-C 633
Query: 646 HLYCQSKETGDVAYMKQLVHDGTHCSYKDPY--SICVRGECVKVGCDKEIGSNKVEDKCG 703
LYC + V DGT C PY +CV G+C K+GCD IGS ED+CG
Sbjct: 634 ELYCSPLGKESPLLVADRVLDGTPCG---PYETDLCVHGKCQKIGCDGIIGSAAKEDRCG 690
Query: 704 VCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHY 763
VC GD C VKG F+ AR +++ K + G +
Sbjct: 691 VCSGDGKTCHLVKGDFSH----------------ARGTALKDSGKGSINSDWKIELPGEF 734
Query: 764 ILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYK 823
+ G + ++ G+ W E + GP P+ ++++ +D + Y+
Sbjct: 735 QIAG-----TTVRYVRRGL-W--------EKISAKGPTKLPLHLMVL-LFHDQDYGIHYE 779
Query: 824 YIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRR--KSDNKMV 881
Y + + N + + + F W W CS CGGG + T C R +V
Sbjct: 780 YTVPVNRTAE-NQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLV 838
Query: 882 HRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGT 941
+ S C +P+P R CN+ C WVA W C+ TC G+Q R V C+ L +GT
Sbjct: 839 NDSDCPQASRPEPQVRRCNLHPC-QSRWVAGPWSPCSATC-EKGFQHREVTCVYQLQNGT 896
Query: 942 NRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC-RAGDHCD 1000
+ + YC G RP + + C C + W+ WS+CS +CG+G R V C + CD
Sbjct: 897 HVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQGKCD 956
Query: 1001 GE-KPESVRACQ 1011
+P + AC+
Sbjct: 957 ASTRPRAEEACE 968
Score = 42.4 bits (98), Expect = 0.003
Identities = 31/89 (34%), Positives = 34/89 (38%), Gaps = 10/89 (11%)
Query: 934 LQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKT-GPWSECSVTCGEGTEVRQVL 992
L P LDGT K+C S+ P W G WS CS TCG G RQ
Sbjct: 512 LDPPLDGTECGA-DKWCRAGECVSKTPIPE-HVDGDWSPWGAWSMCSRTCGTGARFRQRK 569
Query: 993 C------RAGDHCDGEKPESVRACQLPPC 1015
C G HC G E C+ PC
Sbjct: 570 CDNPPPGPGGTHCPGASVEHA-VCENLPC 597
Score = 41.6 bits (96), Expect = 0.005
Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 6/58 (10%)
Query: 847 FEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR----MCN 900
+EW WS CS CG G Q C K + H S C A KP P R+ +CN
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR--HGSECPALSKPAPYRQCYQEVCN 1029
Score = 39.3 bits (90), Expect = 0.023
Identities = 32/125 (25%), Positives = 47/125 (37%), Gaps = 19/125 (15%)
Query: 516 CKTKKGPPLDGTECAAGKWC--YKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRF 573
C +G T A + C Y G WK G W+ +CS TCG G++
Sbjct: 948 CTNSQGKCDASTRPRAEEACEDYSGCYEWKT----------GDWS---TCSSTCGKGLQS 994
Query: 574 RTRQCNNPMPINGGQDCPGVN--FEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKH 631
R QC + + G +CP ++ Y+ C E C R + Y+ T+
Sbjct: 995 RVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRIN--ANTITSPRLAALTYKCTRD 1052
Query: 632 HWLPY 636
W Y
Sbjct: 1053 QWTVY 1057
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 413 bits (1061), Expect = e-115
Identities = 293/922 (31%), Positives = 424/922 (45%), Gaps = 110/922 (11%)
Query: 75 SNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATY 134
S + L F ITAF +DF+L L P+ Q +AP E ++ P+ GS+
Sbjct: 48 SGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTE---------HLGVPLQGLTGGSSDL 98
Query: 135 RIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEK 194
R C Y GD+ P + A+S C GL G EY I PL ++
Sbjct: 99 R---------RCFYSGDVNAEPDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQR 149
Query: 195 GR--IHVVYKRSAVEQAPIDMSKDFH----YRESDLEGLDDLGTVYGNIHQQLNETMRRR 248
H++ +R D + + + L LD Y E+ RR
Sbjct: 150 NSQGAHLLQRRGVPGGPSGDPTSRCGVASGWNPAILRALDP----YKPRRAGFGESRSRR 205
Query: 249 RHAGENDY-----NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINV 303
R + +E L+ D+S+V+FHG + +++YLLTL+ +Y S+ IN+
Sbjct: 206 RSGRAKRFVSIPRYVETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINI 264
Query: 304 VLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGP 363
V+V++++L S + GN + +L N C W + + H E+ D AI TRQD
Sbjct: 265 VVVKVLLLRDRDSGPKVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCG 323
Query: 364 A---GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDE 418
A G A V MC P RSC++ +DG SAF AHE GHV M HD +
Sbjct: 324 ATTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGK 383
Query: 419 TAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLPE-LPGIN 475
+M+P + WS CS + ++ S DCLLD P LPE LPG +
Sbjct: 384 LRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI--SLPEDLPGAS 441
Query: 476 YSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTECAAGKW 534
Y++ +QC FGVG K C + C +LWC+ C+T+ P DGT C GK
Sbjct: 442 YTLSQQCELAFGVGSKPCPYMQY---CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKL 498
Query: 535 CYKGHCMWK-NANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGV 593
C KG C+ + N N+ + DG+W W +G CSRTCG GV+ RQC NP P NGG+ C GV
Sbjct: 499 CLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGV 558
Query: 594 NFEYQLCNTEECQKHF--EDFRAQQCQQRNSHFEYQN---TKHHWLP-YEHPDPKKRCHL 647
+Y+ CN E C + FR +QC+ N + N W+P Y P+ +C L
Sbjct: 559 RVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKL 618
Query: 648 YCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGG 707
C++ TG + V DGT CS D S+CV+G+C+K GCD +GS K DKCGVCGG
Sbjct: 619 ICRANGTGYFYVLAPKVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGG 677
Query: 708 DNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDE-----ASPHILAIKNQATGH 762
DN C+ V G FT+ GY + IP GA + I++ + LA+KN + G
Sbjct: 678 DNKSCKKVTGLFTKPMH--GYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKN-SQGK 734
Query: 763 YILNGKGEEAKSRTFIDLGVEWDYNIEDD----------IESLHTDGPLHDPVIVLIIPQ 812
Y+LNG F+ VE D ++ +ESL P+ +P+ V ++
Sbjct: 735 YLLNGH--------FVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSV 786
Query: 813 ENDTRSSLTYKYII----HEDSV--------PTINSNNVIQ--------EELDTFEWALK 852
T + Y + + ED P++ N+V+ ++ W
Sbjct: 787 GKMTPPRVRYSFYLPKEPREDKSSHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAG 846
Query: 853 SWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAE 912
SW CS CG G Q CR + + V C+A +P+ + C P W
Sbjct: 847 SWGPCSASCGSGLQKRAVDCRGSAGQRTV--PACDA--AHRPVETQACGEPC--PTWELS 900
Query: 913 EWEHCTKTCGSSGYQLRTVRCL 934
W C+K+CG G+Q R+++C+
Sbjct: 901 AWSPCSKSCG-RGFQRRSLKCV 921
Score = 60.5 bits (145), Expect = 1e-08
Identities = 41/122 (33%), Positives = 54/122 (44%), Gaps = 29/122 (23%)
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRC-------LQPLLDGTNRSVHSKYCMGDRPESRRPC 961
WVA W C+ +CGS G Q R V C P D +R V ++ C G+
Sbjct: 843 WVAGSWGPCSASCGS-GLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC-GE-------- 892
Query: 962 NRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC-------RAGDHCD-GEKPESVRACQLP 1013
PCP W+ WS CS +CG G + R + C A D C+ KP+ + C L
Sbjct: 893 ---PCPT-WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLR 948
Query: 1014 PC 1015
PC
Sbjct: 949 PC 950
Score = 42.0 bits (97), Expect = 0.004
Identities = 24/61 (39%), Positives = 29/61 (47%), Gaps = 13/61 (21%)
Query: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCR--AGDH----CD-GEKPESVRACQLPPCNDEP 1019
PA+W G W CS +CG G + R V CR AG CD +P +AC EP
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC------GEP 893
Query: 1020 C 1020
C
Sbjct: 894 C 894
Score = 41.2 bits (95), Expect = 0.006
Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 13/111 (11%)
Query: 915 EHCTK---TCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQW- 970
++CTK T + G + R P DGT+ K C+ R N+ W
Sbjct: 463 QYCTKLWCTGKAKGQMVCQTRHF-PWADGTSCG-EGKLCLKGACVERHNLNKHRVDGSWA 520
Query: 971 KTGPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESVRACQLPPC 1015
K P+ CS TCG G ++ + C G +C+G + + R+C L PC
Sbjct: 521 KWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVK-YRSCNLEPC 570
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 393 bits (1010), Expect = e-109
Identities = 277/907 (30%), Positives = 422/907 (46%), Gaps = 108/907 (11%)
Query: 86 AFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTN 145
AF + L L+P++ +APG ++ N+ + GS T E +
Sbjct: 80 AFDQQLDLELRPDSSFLAPGFTLQ---------NV-----GRKSGSET---PLPETDLAH 122
Query: 146 CAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKG---------R 196
C Y G + P ++ A+S C+G+ G E YFI+PL + +
Sbjct: 123 CFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQ 182
Query: 197 IHVVYKR---------SAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNE---- 243
H++ + V+ P K E + +D G + L
Sbjct: 183 FHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQP 242
Query: 244 ----TMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGV 299
++R++R + Y +E +L D S+ FHG +++YLLTL ++ +Y S+
Sbjct: 243 TGTGSIRKKRFVSSHRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRN 300
Query: 300 HINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQ 359
+++V+V+++++ + + N + +L N C W Q +EH+D AI TRQ
Sbjct: 301 SVSLVVVKILVIHDEQKGPEVT-SNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQ 359
Query: 360 DFGPAGMQ-----GYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNR 414
D G Q G A V +C P RSC++ +DG +AF AHE GHV M HD +
Sbjct: 360 DL--CGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQ 416
Query: 415 CGDETAMGS---VMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLP 469
C + +MA ++ H WS CS + ++ + +CL+D P + +LP
Sbjct: 417 CASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP--QNPIQLP 474
Query: 470 -ELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGT 527
+LPG +Y + QC+F FG K C + C LWC+ C+TK P DGT
Sbjct: 475 GDLPGTSYDANRQCQFTFGEDSKHCPDAAS--TCSTLWCTGTSGGVLVCQTKHFPWADGT 532
Query: 528 ECAAGKWCYKGHCMWKNANQQKQD---GNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPI 584
C GKWC G C+ K + G+WG W +G CSRTCG GV++ R+C+NP+P
Sbjct: 533 SCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPK 592
Query: 585 NGGQDCPGVNFEYQLCNTEEC-QKHFEDFRAQQCQQRNSHFEY---QNTKHHWLP-YEHP 639
NGG+ C G Y+ CN E+C + + FR +QC+ N + W+P Y
Sbjct: 593 NGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGV 652
Query: 640 DPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVE 699
PK RC L CQ+K G ++ V DGT CS D S+CV+G+CVK GCD+ I S K
Sbjct: 653 SPKDRCKLICQAKGIGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKF 711
Query: 700 DKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQE-----DEASPHILA 754
DKCGVCGG+ S C+ + G+ T K GY + IP GA ++ +++ + LA
Sbjct: 712 DKCGVCGGNGSTCKKISGSVTSA--KPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLA 769
Query: 755 IKNQATGHYILNGKGE-EAKSRTFIDLGVEWDYN-IEDDIESLHTDGPLHDPVIVLIIPQ 812
IK A G YILNG + + GV Y+ +E + + PL +P+ + ++
Sbjct: 770 IK-AADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTV 828
Query: 813 ENDTRSSLTYKYIIHE-----DSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQY 867
N R + Y Y + + +++PT ++ W ++ W +CSK C G+Q
Sbjct: 829 GNALRPKIKYTYFVKKKKESFNAIPTFSA------------WVIEEWGECSKSCELGWQR 876
Query: 868 TKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQ 927
CR D S C KP R C C P W EW C+KTCG GY+
Sbjct: 877 RLVECR---DINGQPASECAKEVKPAS-TRPCADHPC--PQWQLGEWSSCSKTCG-KGYK 929
Query: 928 LRTVRCL 934
R+++CL
Sbjct: 930 KRSLKCL 936
Score = 72.0 bits (175), Expect = 3e-12
Identities = 38/93 (40%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 905 THPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRV 964
T WV EEW C+K+C G+Q R V C N S+ +P S RPC
Sbjct: 854 TFSAWVIEEWGECSKSC-ELGWQRRLVECRD-----INGQPASECAKEVKPASTRPCADH 907
Query: 965 PCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGD 997
PCP QW+ G WS CS TCG+G + R + C + D
Sbjct: 908 PCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHD 939
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/124 (28%), Positives = 51/124 (41%), Gaps = 20/124 (16%)
Query: 912 EEWEHC---TKTC------GSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCN 962
E+ +HC TC G+SG L P DGT+ K+C+ + ++
Sbjct: 494 EDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCG-EGKWCINGKCVNKTDRK 552
Query: 963 RVPCP--AQWKT-GPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESVRACQLP 1013
P W GPW +CS TCG G + C G +C+G++ R+C L
Sbjct: 553 HFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVR-YRSCNLE 611
Query: 1014 PCND 1017
C D
Sbjct: 612 DCPD 615
Score = 38.9 bits (89), Expect = 0.030
Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 1/60 (1%)
Query: 962 NRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR-AGDHCDGEKPESVRACQLPPCNDEPC 1020
N +P + W W ECS +C G + R V CR E + V+ PC D PC
Sbjct: 850 NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPC 909
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 377 bits (968), Expect = e-104
Identities = 265/826 (32%), Positives = 387/826 (46%), Gaps = 86/826 (10%)
Query: 143 QTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIHV--- 199
+++C Y G + P + C GL G + Y ++PL RG EEEKGR++
Sbjct: 127 RSHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGS 186
Query: 200 -----VYKRS---------------------AVEQAPIDMSKDFHYR-ESDLEGLDDLGT 232
VY R A E AP + S L L
Sbjct: 187 ARILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSP 246
Query: 233 VYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIY 292
G+ Q RRRR + +E+LL D S+ R +G+ +Q+YLLTL +I N +Y
Sbjct: 247 AGGSGPQTW---WRRRRRSISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRLY 302
Query: 293 HDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDH 352
S+ HI + +V++++LG K SL N + +L+N C+W Q + +H EH+D
Sbjct: 303 SHASIENHIRLAVVKVVVLG-DKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDA 361
Query: 353 AIFLTRQDF---GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHD 409
AI TR+D G A V +C P RSC + +DG +AF VAHE GH+LG+ HD
Sbjct: 362 AILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHD 421
Query: 410 GQGNRCGDETAMGS-----VMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFD 462
C E GS +M+ ++ + WS+C+ + ++ +CLLD P
Sbjct: 422 -DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRK 478
Query: 463 HDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHP-DNPYFCKTKKG 521
ELPG Y +QC FG Y +C D C +LWC+ C TKK
Sbjct: 479 QILGP-EELPGQTYDATQQCNLTFGPEYSVCPGM---DVCARLWCAVVRQGQMVCLTKKL 534
Query: 522 PPLDGTECAAGKWCYKGHCMWKNANQQ---KQDGNWGSWTKFGSCSRTCGTGVRFRTRQC 578
P ++GT C G+ C +G C+ K + GNWGSW +G CSR+CG GV+F R C
Sbjct: 535 PAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHC 594
Query: 579 NNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRN---SHFEYQNTKHHWLP 635
NNP P N G+ C G Y+ C+ C + + FR +QC+ +N S + T W+P
Sbjct: 595 NNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVP 654
Query: 636 -YEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIG 694
Y P C L C++K TG V DGT C S+CVRG+CV+ GCD IG
Sbjct: 655 KYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYS-NSVCVRGKCVRTGCDGIIG 713
Query: 695 SNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPH--- 751
S DKCGVCGGDNS C + GTF + + GY + IP GA H+ +++ +A
Sbjct: 714 SKLQYDKCGVCGGDNSSCTKIVGTFNK--KSKGYTDVVRIPEGATHIKVRQFKAKDQTRF 771
Query: 752 --ILAIKNQATGHYILNGKGEEAKSRTFIDL-GVEWDY---NIEDDIESLHTDG--PLHD 803
LA+K + G Y++NGK + S T ID+ G +Y + DD LH G +
Sbjct: 772 TAYLALKKK-NGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDF--LHGMGYSATKE 828
Query: 804 PVIVLIIPQENDTRSSLTYKYIIHEDSVPTINS-----NNVIQEELDTFEWALKSWSQCS 858
+IV I+ + + Y + + + S P +NS +N + +W W CS
Sbjct: 829 ILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACS 888
Query: 859 KPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
+ C G+ C+ D C +++P ++ C +++C
Sbjct: 889 RTCDTGWHTRTVQCQ---DGNRKLAKGCPLSQRPSAFKQ-CLLKKC 930
Score = 42.0 bits (97), Expect = 0.004
Identities = 20/53 (37%), Positives = 26/53 (49%), Gaps = 6/53 (11%)
Query: 969 QWKTGPWSECSVTCGEGTEVRQVLCRAGDH-----CD-GEKPESVRACQLPPC 1015
QW TGPW CS TC G R V C+ G+ C ++P + + C L C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 35.8 bits (81), Expect = 0.25
Identities = 22/78 (28%), Positives = 32/78 (41%), Gaps = 7/78 (8%)
Query: 914 WEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTG 973
W C+++CG G Q C P R YC G R R C+ +PCP K+
Sbjct: 576 WGQCSRSCGG-GVQFAYRHCNNPAPRNNGR-----YCTGKRA-IYRSCSLMPCPPNGKSF 628
Query: 974 PWSECSVTCGEGTEVRQV 991
+C G ++ + V
Sbjct: 629 RHEQCEAKNGYQSDAKGV 646
Score = 32.0 bits (71), Expect = 3.6
Identities = 17/49 (34%), Positives = 22/49 (44%), Gaps = 7/49 (14%)
Query: 973 GPWSECSVTCGEGTEVRQVLC------RAGDHCDGEKPESVRACQLPPC 1015
G W +CS +CG G + C G +C G K R+C L PC
Sbjct: 574 GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG-KRAIYRSCSLMPC 621
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 374 bits (959), Expect = e-103
Identities = 272/873 (31%), Positives = 404/873 (46%), Gaps = 84/873 (9%)
Query: 79 QLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRK 138
+L +++AFGK F LRL P+ +AP +E S G AT R
Sbjct: 52 ELALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGS---------------GRATGGERG 96
Query: 139 TEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKGRIH 198
C + G + P + A+S C GL+G D EE+ I+P G + + H
Sbjct: 97 LR----GCFFSGTVNGEPESLAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQP----H 148
Query: 199 VVYKRSAVEQAPIDMSKDF--------------HYRESDLEGLDDLGTVYGNIHQQLNET 244
+ + P+ ++ H +S+ E ++ L T
Sbjct: 149 RLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGAT 208
Query: 245 MRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVV 304
R +R E + +E LL D S+ F+G + +QN++LTLM++ IY S+ IN++
Sbjct: 209 SRTKRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAARIYKHPSIKNSINLM 266
Query: 305 LVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF--- 361
+V+++++ K + N +L N C W + + H EH+D AI LTRQ+F
Sbjct: 267 VVKVLIVEDEKWGPEVS-DNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQ 325
Query: 362 -GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDE 418
G G A + +C P +SC++ ++G +A +AHE GHVL M HD R
Sbjct: 326 EGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGP 385
Query: 419 TAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLPELPG--I 474
VMAPL WS CS L + DCLLD P P LPG
Sbjct: 386 MGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA-LPLPTGLPGRMA 444
Query: 475 NYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKG--PPLDGTECAAG 532
Y +D+QCR FG ++ C D C QLWC C TK G P DGT C G
Sbjct: 445 LYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPG 504
Query: 533 KWCYKGHCMWKNANQQKQ---DGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQD 589
C +G C+ + ++ + DG W W +G CSRTCG GV+F R+C +P P NGG+
Sbjct: 505 HLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY 564
Query: 590 CPGVNFEYQLCNTEECQKHFEDFRAQQCQQRN--SHFEYQNTKHHWLP-YEHPDPKKRCH 646
C G +YQ C+TEEC + FR QQC++ N ++ + W+P Y P+ RC
Sbjct: 565 CLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVPKYAGVSPRDRCK 624
Query: 647 LYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCG 706
L+C+++ + + V DGT C + +ICVRG+CVK GCD + S + DKCGVCG
Sbjct: 625 LFCRARGRSEFKVFEAKVIDGTLCG-PETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCG 683
Query: 707 GDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQED-----EASPHILAIKNQATG 761
G + CR V G+ TP GY + IP GA ++ +++ + + LA+K A G
Sbjct: 684 GKGNSCRKVSGSL--TPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKT-ADG 740
Query: 762 HYILNGK-GEEAKSRTFIDLGVEWDYNIE-DDIESLHTDGPLHDPVIVLIIPQENDT-RS 818
Y+LNG A + + G Y+ +E L + PL +P+ V ++ +
Sbjct: 741 QYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPP 800
Query: 819 SLTYKYIIHEDSVPTINSN------NVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGC 872
+ Y + + D ++ S+ N+IQ L +W L WS+CS CG G+Q C
Sbjct: 801 KVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHA-QWVLGDWSECSSTCGAGWQRRTVEC 859
Query: 873 RRKSDNKMVHRSFCEANKKPKP-IRRMCNIQEC 904
R S ++ NK KP + C Q C
Sbjct: 860 RDPSG-----QASATCNKALKPEDAKPCESQLC 887
Score = 47.4 bits (111), Expect = 8e-05
Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 6/67 (8%)
Query: 901 IQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP 960
IQ H WV +W C+ TCG +G+Q RTV C P G + +K +PE +P
Sbjct: 828 IQPLLHAQWVLGDWSECSSTCG-AGWQRRTVECRDP--SGQASATCNKAL---KPEDAKP 881
Query: 961 CNRVPCP 967
C CP
Sbjct: 882 CESQLCP 888
Score = 45.1 bits (105), Expect = 4e-04
Identities = 24/54 (44%), Positives = 28/54 (51%), Gaps = 6/54 (11%)
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLCR-----AGDHCD-GEKPESVRACQLPPC 1015
AQW G WSECS TCG G + R V CR A C+ KPE + C+ C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 37.4 bits (85), Expect = 0.087
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 2/64 (3%)
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIF 1027
A W GPW ECS TCG G + C+ + +G + R + C+ E C D F
Sbjct: 530 APW--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSF 587
Query: 1028 CQME 1031
+ +
Sbjct: 588 REQQ 591
Score = 31.2 bits (69), Expect = 6.2
Identities = 19/65 (29%), Positives = 27/65 (41%), Gaps = 7/65 (10%)
Query: 914 WEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTG 973
W C++TCG G Q C P R YC+G R + + C+ CP K+
Sbjct: 535 WGECSRTCG-GGVQFSHRECKDPEPQNGGR-----YCLGRRAK-YQSCHTEECPPDGKSF 587
Query: 974 PWSEC 978
+C
Sbjct: 588 REQQC 592
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 324 bits (831), Expect = 3e-88
Identities = 247/817 (30%), Positives = 361/817 (44%), Gaps = 65/817 (7%)
Query: 246 RRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVL 305
+R+R A ++E+L+ V V + H +E + Y+LT +NI E+ D SLG V L
Sbjct: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
Query: 306 VRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF---- 361
V+M++L + I N + SL +VC W+ D H D +++TR D
Sbjct: 129 VKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 362 GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDETA 420
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
Query: 421 MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHS--YDCLLDDPFDHDWPK--LPEL-PGIN 475
G VMA A WS CS ++L + + C+ D P P+ PG+
Sbjct: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLY 304
Query: 476 YSMDEQCRFDFGVGYKMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAAGK 533
YS +EQCR FG CT R D C+ L C + P + C P LDGTEC K
Sbjct: 305 YSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEK 364
Query: 534 WCYKGHC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCP 591
WC KG C + + G W SW CSR+CG GV R RQCNNP P GG+ C
Sbjct: 365 WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACV 424
Query: 592 GVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQN----TKHHW-LPYEHPDPKKRCH 646
G + + ++CNT+ C+K +F +QQC + + + + +HW H C
Sbjct: 425 GADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCR 484
Query: 647 LYCQSKETGDVAYMKQLVHDGTHCSYKDP-----YSICVRGECVKVGCDKEIGSNKVEDK 701
C++ + DGT C P S+CV G C GCD + S +V D+
Sbjct: 485 HMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDR 544
Query: 702 CGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATG 761
C VCGGDNS C KG+FT R Y+ + P V I LA++ G
Sbjct: 545 CQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGG 601
Query: 762 HYILNGKGEEAKSRTFIDL----GVEWDYNIEDD----IESLHTDGPLHDPVIVLIIPQE 813
Y++ GK + + T+ L VE+ + +D +E + GPL + + + +
Sbjct: 602 RYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRY 661
Query: 814 NDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCR 873
+ +LT P I + + WA CS CG G ++ Y C
Sbjct: 662 GEEYGNLTR---------PDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCL 711
Query: 874 RKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRC 933
++ ++V C+ +++P C ++ C P W ++ C+ +CG G + R VRC
Sbjct: 712 DQARKELVETVQCQGSQQPPAWPEACVLEPCP-PYWAVGDFGPCSASCG-GGLRERPVRC 769
Query: 934 L--QPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQV 991
+ Q L T + + CN PCPA+W+ S C+ G G +
Sbjct: 770 VEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENE 829
Query: 992 LCRAGDHCDG------EKPESVRACQLPPCNDEPCLG 1022
C G DG E P SV +LP EPC+G
Sbjct: 830 TCVPG--ADGLEAPVTEGPGSVDE-KLPA--PEPCVG 861
Score = 75.5 bits (184), Expect = 3e-13
Identities = 54/180 (30%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 857 CSKPCGGGFQYTKYGCRRK----SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAE 912
CS CG G C R +++ + C+ +P+P + C+++ C P W
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWKVM 1019
Query: 913 EWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQWK 971
C+ +CG G R+V C+Q L G + V C RPE+ PC C +W
Sbjct: 1020 SLGPCSASCGL-GTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1077
Query: 972 TGPWSECSVTCGEGTEVRQVLCRA--------GDHCDG-EKPESVRACQLPPCNDEPCLG 1022
G W ECSV+CG+G + R+ C D C KP +VR C PC + G
Sbjct: 1078 VGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACG 1137
Score = 66.2 bits (160), Expect = 2e-10
Identities = 50/172 (29%), Positives = 67/172 (38%), Gaps = 14/172 (8%)
Query: 857 CSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEH 916
CS CG G ++ C + V C KP R +C C W++
Sbjct: 904 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC------PARWQY 957
Query: 917 ----CTKTCGSSGYQLRTVRCLQPL-LDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQW 970
C+ +CG G R + C + D + C G RPE + C+ PCP +W
Sbjct: 958 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRW 1016
Query: 971 KTGPWSECSVTCGEGTEVRQVLCRAGDH-CDGEKPESVRACQLPPCNDEPCL 1021
K CS +CG GT R V C D D E E+ A + P PCL
Sbjct: 1017 KVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCL 1068
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/128 (28%), Positives = 51/128 (39%), Gaps = 9/128 (7%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRR--KSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
W + S CS CG G C + + + V + C A +P+ C I +CT+
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE-ASVPCLIADCTY 1074
Query: 907 PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVP 965
W W C+ +CG G Q R CL P V + +C +P + R C P
Sbjct: 1075 -RWHVGTWMECSVSCG-DGIQRRRDTCLGP---QAQAPVPADFCQHLPKPVTVRGCWAGP 1129
Query: 966 CPAQWKTG 973
C Q G
Sbjct: 1130 CVGQGACG 1137
Score = 37.7 bits (86), Expect = 0.066
Identities = 16/51 (31%), Positives = 23/51 (45%)
Query: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIR 896
T+ W + +W +CS CG G Q + C V FC+ KP +R
Sbjct: 1073 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1123
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 324 bits (831), Expect = 3e-88
Identities = 247/817 (30%), Positives = 361/817 (44%), Gaps = 65/817 (7%)
Query: 246 RRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVL 305
+R+R A ++E+L+ V V + H +E + Y+LT +NI E+ D SLG V L
Sbjct: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
Query: 306 VRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF---- 361
V+M++L + I N + SL +VC W+ D H D +++TR D
Sbjct: 129 VKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 362 GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDETA 420
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
Query: 421 MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHS--YDCLLDDPFDHDWPK--LPEL-PGIN 475
G VMA A WS CS ++L + + C+ D P P+ PG+
Sbjct: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLY 304
Query: 476 YSMDEQCRFDFGVGYKMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAAGK 533
YS +EQCR FG CT R D C+ L C + P + C P LDGTEC K
Sbjct: 305 YSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEK 364
Query: 534 WCYKGHC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCP 591
WC KG C + + G W SW CSR+CG GV R RQCNNP P GG+ C
Sbjct: 365 WCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACV 424
Query: 592 GVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQN----TKHHW-LPYEHPDPKKRCH 646
G + + ++CNT+ C+K +F +QQC + + + + +HW H C
Sbjct: 425 GADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCR 484
Query: 647 LYCQSKETGDVAYMKQLVHDGTHCSYKDP-----YSICVRGECVKVGCDKEIGSNKVEDK 701
C++ + DGT C P S+CV G C GCD + S +V D+
Sbjct: 485 HMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDR 544
Query: 702 CGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATG 761
C VCGGDNS C KG+FT R Y+ + P V I LA++ G
Sbjct: 545 CQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGG 601
Query: 762 HYILNGKGEEAKSRTFIDL----GVEWDYNIEDD----IESLHTDGPLHDPVIVLIIPQE 813
Y++ GK + + T+ L VE+ + +D +E + GPL + + + +
Sbjct: 602 RYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRY 661
Query: 814 NDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCR 873
+ +LT P I + + WA CS CG G ++ Y C
Sbjct: 662 GEEYGNLTR---------PDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCL 711
Query: 874 RKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRC 933
++ ++V C+ +++P C ++ C P W ++ C+ +CG G + R VRC
Sbjct: 712 DQARKELVETVQCQGSQQPPAWPEACVLEPCP-PYWAVGDFGPCSASCG-GGLRERPVRC 769
Query: 934 L--QPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQV 991
+ Q L T + + CN PCPA+W+ S C+ G G +
Sbjct: 770 VEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENE 829
Query: 992 LCRAGDHCDG------EKPESVRACQLPPCNDEPCLG 1022
C G DG E P SV +LP EPC+G
Sbjct: 830 TCVPG--ADGLEAPVTEGPGSVDE-KLPA--PEPCVG 861
Score = 75.1 bits (183), Expect = 4e-13
Identities = 53/173 (30%), Positives = 76/173 (43%), Gaps = 18/173 (10%)
Query: 857 CSKPCGGGFQYTKYGCRRK----SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAE 912
CS CG G C R +++ + C+ +P+P + C+++ C P W
Sbjct: 962 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWKVM 1019
Query: 913 EWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQWK 971
C+ +CG G R+V C+Q L G + V C RPE+ PC C +W
Sbjct: 1020 SLGPCSASCGL-GTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1077
Query: 972 TGPWSECSVTCGEGTEVRQVLCRA--------GDHCDG-EKPESVRACQLPPC 1015
G W ECSV+CG+G + R+ C D C KP +VR C PC
Sbjct: 1078 VGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 66.2 bits (160), Expect = 2e-10
Identities = 50/172 (29%), Positives = 67/172 (38%), Gaps = 14/172 (8%)
Query: 857 CSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEH 916
CS CG G ++ C + V C KP R +C C W++
Sbjct: 904 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC------PARWQY 957
Query: 917 ----CTKTCGSSGYQLRTVRCLQPL-LDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQW 970
C+ +CG G R + C + D + C G RPE + C+ PCP +W
Sbjct: 958 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRW 1016
Query: 971 KTGPWSECSVTCGEGTEVRQVLCRAGDH-CDGEKPESVRACQLPPCNDEPCL 1021
K CS +CG GT R V C D D E E+ A + P PCL
Sbjct: 1017 KVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCL 1068
Score = 42.4 bits (98), Expect = 0.003
Identities = 35/124 (28%), Positives = 50/124 (40%), Gaps = 9/124 (7%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRR--KSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
W + S CS CG G C + + + V + C A +P+ C I +CT+
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE-ASVPCLIADCTY 1074
Query: 907 PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVP 965
W W C+ +CG G Q R CL P V + +C +P + R C P
Sbjct: 1075 -RWHVGTWMECSVSCG-DGIQRRRDTCLGP---QAQAPVPADFCQHLPKPVTVRGCWAGP 1129
Query: 966 CPAQ 969
C Q
Sbjct: 1130 CVGQ 1133
Score = 37.7 bits (86), Expect = 0.066
Identities = 16/51 (31%), Positives = 23/51 (45%)
Query: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIR 896
T+ W + +W +CS CG G Q + C V FC+ KP +R
Sbjct: 1073 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1123
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 313 bits (801), Expect = 8e-85
Identities = 235/780 (30%), Positives = 353/780 (45%), Gaps = 79/780 (10%)
Query: 74 SSNPEQLFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSAT 133
S P +L + AFG+ L L+ ++ + G V++ G + + +PG+
Sbjct: 75 SGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYL------GQAPELLGGAEPGT-- 126
Query: 134 YRIRKTEPLQTNCAYVGDIVDIPGTSVAISNCDG--LAGMIKSDNEEYFIEPLERGKQME 191
Y+ ++ SVA + DG L G+++ E ++PLE G
Sbjct: 127 --------------YLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNS 172
Query: 192 EEKGRIHVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRRRRHA 251
H++ R+S G + V + R +R A
Sbjct: 173 AGGPGAHILR------------------RKSPASGQGPMCNVKAPLGSPSPRPRRAKRFA 214
Query: 252 GENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIML 311
+ + +E L+ DD + FHG ++ YLLT+M + + S+ +++V+ R+++L
Sbjct: 215 SLSRF-VETLVVADDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVIL 272
Query: 312 GYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF---GPAGMQG 368
G + + + +++L + C W + + +H D AI TRQD G
Sbjct: 273 GSGEEGPQVGP-SAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLG 331
Query: 369 YAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG---NRCGDETAMGSVM 425
A V +C P RSC + +DG SAF AHE GHV M HD + G + VM
Sbjct: 332 MADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVM 391
Query: 426 APLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWP-KLP-ELPGINYSMDEQ 481
AP++ WS CS + + ++ + CLLD P + P LP PG +Y D Q
Sbjct: 392 APVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKP---EAPLHLPVTFPGKDYDADRQ 448
Query: 482 CRFDFGVGYKMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC 540
C+ FG + C PC LWCS H + C+TK P DGT C + C G C
Sbjct: 449 CQLTFGPDSRHCPQLPP--PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRC 506
Query: 541 MWKNANQQ---KQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEY 597
+ + Q Q G WG W +G CSRTCG GV+F +R C P+P NGG+ C G +
Sbjct: 507 LHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRF 566
Query: 598 QLCNTEECQKHFE-DFRAQQC---QQRNSHFEYQNTKHHWLP-YEHPDPKKRCHLYCQSK 652
+ CNTE+C FR +QC R F+ W+P Y P+ +C L CQ++
Sbjct: 567 RSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQ 626
Query: 653 ETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHC 712
G ++ V DGT CS D S+CV+G C+ GCD+ IGS K DKC VCGGD S C
Sbjct: 627 ALGYYYVLEPRVVDGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGC 685
Query: 713 RTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPH---ILAIKNQATGHYILNGKG 769
G+F + + GY + IP GA H+L+++ H LA+K G Y LNG+
Sbjct: 686 SKQSGSFRKF--RYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALK-LPDGSYALNGEY 742
Query: 770 EEAKSRTFIDL--GVEWDYN-IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYII 826
S T + L V Y+ E+L GPL P+ + ++ N + L Y + +
Sbjct: 743 TLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFV 802
Score = 39.3 bits (90), Expect = 0.023
Identities = 63/271 (23%), Positives = 96/271 (35%), Gaps = 49/271 (18%)
Query: 799 GPLHDPVIVLIIPQENDTRSSLTYKY-------IIHEDSVPTINSNNVIQEELDTFEWAL 851
G + DP I +++ +S+ T + ++H++S P I+ N + +
Sbjct: 336 GTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVM 395
Query: 852 ------KSWSQCSKPCGGGFQYTKYG-CRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
+ WS CS F YG C +H K R C
Sbjct: 396 AHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKD-YDADRQCQ---- 450
Query: 905 THPLWVAEEWEHCTKT---CGS---SGYQLRTVRCL---QPLLDGTNRSVHSKYCMGDR- 954
L + HC + C + SG+ C P DGT ++ CMG R
Sbjct: 451 ---LTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGP-AQACMGGRC 506
Query: 955 --PESRRPCNRVPCPAQWKT-GPWSECSVTCGEGTE------VRQVLCRAGDHCDGEKPE 1005
+ + N +P W GPW +CS TCG G + R V G +C+G
Sbjct: 507 LHMDQLQDFN-IPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEG---- 561
Query: 1006 SVRACQLPPCNDEPCLGDKSIFCQMEVLARY 1036
R + CN E C ++ + E A Y
Sbjct: 562 --RRTRFRSCNTEDCPTGSALTFREEQCAAY 590
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 312 bits (800), Expect = 1e-84
Identities = 240/812 (29%), Positives = 350/812 (43%), Gaps = 86/812 (10%)
Query: 246 RRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVL 305
+R+R A ++E+L+ V V + H +E + Y+LT +NI E+ D SLG V L
Sbjct: 70 QRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRVHL 128
Query: 306 VRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDF---- 361
V+M++L + I N + SL +VC W+ D H D +++TR D
Sbjct: 129 VKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPD 187
Query: 362 GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDETA 420
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 188 GNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS-- 245
Query: 421 MGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDE 480
G VMA A WS CS ++L + S +E
Sbjct: 246 -GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SANE 278
Query: 481 QCRFDFGVGYKMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTECAAGKWCYKG 538
QCR FG CT R D C+ L C + P + C P LDGTEC KWC KG
Sbjct: 279 QCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKG 338
Query: 539 HC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFE 596
C + + G W SW CSR+CG GV R RQCNNP P GG+ C G + +
Sbjct: 339 RCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQ 398
Query: 597 YQLCNTEECQKHFEDFRAQQCQQRNSHFEYQN----TKHHW-LPYEHPDPKKRCHLYCQS 651
++CNT+ C+K +F +QQC + + + + +HW H C C++
Sbjct: 399 AEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMCRA 458
Query: 652 KETGDVAYMKQLVHDGTHCSYKDP-----YSICVRGECVKVGCDKEIGSNKVEDKCGVCG 706
+ DGT C P S+CV G C GCD + S +V D+C VCG
Sbjct: 459 IGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCG 518
Query: 707 GDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILN 766
GDNS C KG+FT R Y+ + P V I LA++ G Y++
Sbjct: 519 GDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGGRYVVA 575
Query: 767 GKGEEAKSRTFIDL----GVEWDYNIEDD----IESLHTDGPLHDPVIVLIIPQENDTRS 818
GK + + T+ L VE+ + +D +E + GPL + + + + +
Sbjct: 576 GKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYG 635
Query: 819 SLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDN 878
+LT P I + + WA CS CG G ++ Y C ++
Sbjct: 636 NLTR---------PDITFTYFQPKPRQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARK 685
Query: 879 KMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCL--QP 936
++V C+ +++P C ++ C P W ++ C+ +CG G + R VRC+ Q
Sbjct: 686 ELVETVQCQGSQQPPAWPEACVLEPCP-PYWAVGDFGPCSASCG-GGLRERPVRCVEAQG 743
Query: 937 LLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAG 996
L T + + CN PCPA+W+ S C+ G G + C G
Sbjct: 744 SLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPG 803
Query: 997 DHCDG------EKPESVRACQLPPCNDEPCLG 1022
DG E P SV +LP EPC+G
Sbjct: 804 --ADGLEAPVTEGPGSVDE-KLPA--PEPCVG 830
Score = 75.5 bits (184), Expect = 3e-13
Identities = 54/180 (30%), Positives = 78/180 (43%), Gaps = 18/180 (10%)
Query: 857 CSKPCGGGFQYTKYGCRRK----SDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAE 912
CS CG G C R +++ + C+ +P+P + C+++ C P W
Sbjct: 931 CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PRWKVM 988
Query: 913 EWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQWK 971
C+ +CG G R+V C+Q L G + V C RPE+ PC C +W
Sbjct: 989 SLGPCSASCGL-GTARRSVACVQ-LDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWH 1046
Query: 972 TGPWSECSVTCGEGTEVRQVLCRA--------GDHCDG-EKPESVRACQLPPCNDEPCLG 1022
G W ECSV+CG+G + R+ C D C KP +VR C PC + G
Sbjct: 1047 VGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGACG 1106
Score = 66.2 bits (160), Expect = 2e-10
Identities = 50/172 (29%), Positives = 67/172 (38%), Gaps = 14/172 (8%)
Query: 857 CSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEH 916
CS CG G ++ C + V C KP R +C C W++
Sbjct: 873 CSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC------PARWQY 926
Query: 917 ----CTKTCGSSGYQLRTVRCLQPL-LDGTNRSVHSKYCMG-DRPESRRPCNRVPCPAQW 970
C+ +CG G R + C + D + C G RPE + C+ PCP +W
Sbjct: 927 KLAACSVSCG-RGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRW 985
Query: 971 KTGPWSECSVTCGEGTEVRQVLCRAGDH-CDGEKPESVRACQLPPCNDEPCL 1021
K CS +CG GT R V C D D E E+ A + P PCL
Sbjct: 986 KVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCL 1037
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/128 (28%), Positives = 51/128 (39%), Gaps = 9/128 (7%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRR--KSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
W + S CS CG G C + + + V + C A +P+ C I +CT+
Sbjct: 985 WKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPE-ASVPCLIADCTY 1043
Query: 907 PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVP 965
W W C+ +CG G Q R CL P V + +C +P + R C P
Sbjct: 1044 -RWHVGTWMECSVSCG-DGIQRRRDTCLGP---QAQAPVPADFCQHLPKPVTVRGCWAGP 1098
Query: 966 CPAQWKTG 973
C Q G
Sbjct: 1099 CVGQGACG 1106
Score = 37.7 bits (86), Expect = 0.066
Identities = 16/51 (31%), Positives = 23/51 (45%)
Query: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIR 896
T+ W + +W +CS CG G Q + C V FC+ KP +R
Sbjct: 1042 TYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1092
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 233 bits (594), Expect = 8e-61
Identities = 165/506 (32%), Positives = 224/506 (44%), Gaps = 77/506 (15%)
Query: 546 NQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 605
+++ +DG W +W + CSRTCG G + R+C + + C G N Y+ C+ +C
Sbjct: 28 SEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDC 81
Query: 606 QKHFEDFRAQQCQQRNSHFEYQNTKHH-----WLPYEHPDPKKRCHLYCQSKETGDVAYM 660
DFRAQQC N + KHH WLP + DP C L CQ+K T V +
Sbjct: 82 PPEAGDFRAQQCSAHN------DVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVEL 134
Query: 661 KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT 720
V DGT C Y + +C+ G C VGCD ++GS ED CGVC GD S CR V+G +
Sbjct: 135 APKVLDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY- 192
Query: 721 RTPRKLGYLKMFD----IPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRT 776
+L K D IP G+RH+ + + H+ G G+ + + T
Sbjct: 193 --KSQLSATKSDDTVVAIPYGSRHIRLVL-KGPDHLYLETKTLQG---TKGENSLSSTGT 246
Query: 777 FIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINS 836
F+ D+ D E L GPL IV I N + T ++I ++ P I+
Sbjct: 247 FLVDNSSVDFQKFPDKEILRMAGPLTADFIVKI---RNSGSADSTVQFIFYQ---PIIH- 299
Query: 837 NNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCE---ANKKPK 893
W + CS CGGG+Q T C N++V +C N KPK
Sbjct: 300 -----------RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
Query: 894 PIRRMCNIQECT--------------HPL--WVAEEWEHCTKTCGSSGYQLRTVRCLQPL 937
P + CN+ C HPL W A W C+ +CG G Q R V C++
Sbjct: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEED 407
Query: 938 LDGTNRSVHSKYCM-GDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--R 994
+ G SV CM + +PCN CP +W WS C+VTCG+G R VLC
Sbjct: 408 IQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDH 466
Query: 995 AGDHCDG----EKPESVRACQLP-PC 1015
G H G KP C +P PC
Sbjct: 467 RGMHTGGCSPKTKPHIKEECIVPTPC 492
Score = 111 bits (278), Expect = 4e-24
Identities = 60/197 (30%), Positives = 89/197 (45%), Gaps = 15/197 (7%)
Query: 840 IQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMC 899
+Q+ + ++W + +++CS+ CGGG Q C K + + C +++P + + C
Sbjct: 602 LQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSC 661
Query: 900 NIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSV--HSKYCMGDRPES 957
N+ C W +W C+ TCG G Q R V C L N +V + C +P +
Sbjct: 662 NLDPCP-ARWEIGKWSPCSLTCG-VGLQTRDVFCSHLLSREMNETVILADELCRQPKPST 719
Query: 958 RRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--RAGD---------HCDGEKPES 1006
+ CNR CP W W CS TCG G + R+VLC R D C KP
Sbjct: 720 VQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPAC 779
Query: 1007 VRACQLPPCNDEPCLGD 1023
+AC+ C E L D
Sbjct: 780 QQACKKDDCPSEWLLSD 796
Score = 107 bits (267), Expect = 7e-23
Identities = 51/149 (34%), Positives = 74/149 (49%), Gaps = 5/149 (3%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFC--EANKKPKPIR-RMCNIQECT 905
W + WS CS CG G Q C +M E ++PKP + CN C
Sbjct: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCP 729
Query: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVP 965
P W +W+ C++TCG G Q R V C Q + DG+ + +C +P ++ C +
Sbjct: 730 -PAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDD 787
Query: 966 CPAQWKTGPWSECSVTCGEGTEVRQVLCR 994
CP++W W+ECS +CGEGT+ R +CR
Sbjct: 788 CPSEWLLSDWTECSTSCGEGTQTRSAICR 816
Score = 87.4 bits (215), Expect = 7e-17
Identities = 56/218 (25%), Positives = 90/218 (41%), Gaps = 19/218 (8%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKM---VHRSFCEANKKPKPIRRMCNIQECT 905
W + SWS C++ CGGG Q + C++ + + V C K + CN Q C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRV 964
W W C C ++ + DG ++ S+ C RP S + C
Sbjct: 1609 E--WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGI--TLPSEQCSALPRPVSTQNCWSE 1664
Query: 965 PCPAQWKTGPWSECSVTCGE-GTEVRQVLC-------RAGDH-CD-GEKPESVRACQLPP 1014
C W+ W+ C+ TCG G + R+V C +H C G +P + + C + P
Sbjct: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
Query: 1015 CNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSK 1052
C + C D + +C+ + C + + CC +C K
Sbjct: 1725 CENMEC-RDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
Score = 76.6 bits (187), Expect = 1e-13
Identities = 57/204 (27%), Positives = 82/204 (40%), Gaps = 44/204 (21%)
Query: 852 KSWSQCSKPCGGGFQYTKYGCR-RKSDNKMVHRSFCEANKKPKPI-RRMCNIQECTHPL- 908
++WS C+ CG G Q C+ S ++ V + + PKP +R C C+ +
Sbjct: 529 EAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIP 588
Query: 909 ----------------------WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVH 946
W E + C+++CG G Q V CL T
Sbjct: 589 EFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVVSCLNKQ---TREPAE 644
Query: 947 SKYCMGDR--PESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR---------- 994
C+ R P+ + CN PCPA+W+ G WS CS+TCG G + R V C
Sbjct: 645 ENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
Query: 995 ---AGDHCDGEKPESVRACQLPPC 1015
A + C KP +V+AC C
Sbjct: 705 VILADELCRQPKPSTVQACNRFNC 728
Score = 67.0 bits (162), Expect = 1e-10
Identities = 41/123 (33%), Positives = 56/123 (45%), Gaps = 10/123 (8%)
Query: 848 EWALKSWSQCSKPCGG---GFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC 904
EWA SW QC+ PC G Q+ + C+ + D + C A P+P+ E
Sbjct: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR-DGITLPSEQCSA--LPRPVSTQNCWSEA 1665
Query: 905 THPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNR 963
W W CT TCG+ G+Q R V C+ TN++V C G RP + + CN
Sbjct: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHA---RTNKAVPEHLCSWGPRPANWQRCNI 1722
Query: 964 VPC 966
PC
Sbjct: 1723 TPC 1725
Score = 64.7 bits (156), Expect = 5e-10
Identities = 42/152 (27%), Positives = 67/152 (44%), Gaps = 36/152 (23%)
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRP--CNRVPC 966
W + C+ +CG+ G Q +RCL L+ T V+ +C G + +P CNR C
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCL---LNSTE--VNPAHCAGKVRPAVQPIACNRRDC 1545
Query: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCR-----------AGDHCD--GEKPESVRACQLP 1013
P++W WS C+ +CG G + R+V C+ + D C ++P +AC
Sbjct: 1546 PSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQ 1605
Query: 1014 PCND----------EPCLG------DKSIFCQ 1029
C + PC+G + +FCQ
Sbjct: 1606 LCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQ 1637
Score = 61.6 bits (148), Expect = 4e-09
Identities = 58/237 (24%), Positives = 86/237 (36%), Gaps = 72/237 (30%)
Query: 845 DTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNI--- 901
D +W + WS C+ CG G +Y C D++ +H C KP I+ C +
Sbjct: 436 DCPKWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPH-IKEECIVPTP 491
Query: 902 --------------------QECTH-------PLWVAEEWEHCTKTCGSSGYQLRTVRCL 934
QE P ++ E W CT TCG G Q+R VRC
Sbjct: 492 CYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG-VGTQVRIVRC- 549
Query: 935 QPLLDGTN--RSVHSKYCMGDRPESRRPCNRVPCPAQ----------------------- 969
Q LL + + C G +P S+R C PC +
Sbjct: 550 QVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELY 609
Query: 970 -WKTGPWSECSVTCGEGTEVRQVLC--------RAGDHC--DGEKPESVRACQLPPC 1015
W+ +++CS +CG G + V C + C P+ +++C L PC
Sbjct: 610 DWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
Score = 37.7 bits (86), Expect = 0.066
Identities = 20/63 (31%), Positives = 27/63 (42%), Gaps = 2/63 (3%)
Query: 843 ELDTFEWALKSWSQCSKPCGG-GFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNI 901
E + W + W+ C+ CG GFQ + C NK V C +P +R CNI
Sbjct: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQR-CNI 1722
Query: 902 QEC 904
C
Sbjct: 1723 TPC 1725
Score = 34.3 bits (77), Expect = 0.73
Identities = 19/63 (30%), Positives = 27/63 (42%), Gaps = 4/63 (6%)
Query: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSD---NKMVHRSFCEANKKPKPIRRMCNIQEC 904
EW L W++CS CG G Q CR+ + +V+ + C I R C + C
Sbjct: 791 EWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI-RPCMLATC 849
Query: 905 THP 907
P
Sbjct: 850 ARP 852
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 233 bits (594), Expect = 8e-61
Identities = 165/506 (32%), Positives = 224/506 (44%), Gaps = 77/506 (15%)
Query: 546 NQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 605
+++ +DG W +W + CSRTCG G + R+C + + C G N Y+ C+ +C
Sbjct: 28 SEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDC 81
Query: 606 QKHFEDFRAQQCQQRNSHFEYQNTKHH-----WLPYEHPDPKKRCHLYCQSKETGDVAYM 660
DFRAQQC N + KHH WLP + DP C L CQ+K T V +
Sbjct: 82 PPEAGDFRAQQCSAHN------DVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVEL 134
Query: 661 KQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFT 720
V DGT C Y + +C+ G C VGCD ++GS ED CGVC GD S CR V+G +
Sbjct: 135 APKVLDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY- 192
Query: 721 RTPRKLGYLKMFD----IPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRT 776
+L K D IP G+RH+ + + H+ G G+ + + T
Sbjct: 193 --KSQLSATKSDDTVVAIPYGSRHIRLVL-KGPDHLYLETKTLQG---TKGENSLSSTGT 246
Query: 777 FIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINS 836
F+ D+ D E L GPL IV I N + T ++I ++ P I+
Sbjct: 247 FLVDNSSVDFQKFPDKEILRMAGPLTADFIVKI---RNSGSADSTVQFIFYQ---PIIH- 299
Query: 837 NNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCE---ANKKPK 893
W + CS CGGG+Q T C N++V +C N KPK
Sbjct: 300 -----------RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPK 348
Query: 894 PIRRMCNIQECT--------------HPL--WVAEEWEHCTKTCGSSGYQLRTVRCLQPL 937
P + CN+ C HPL W A W C+ +CG G Q R V C++
Sbjct: 349 PKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEED 407
Query: 938 LDGTNRSVHSKYCM-GDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--R 994
+ G SV CM + +PCN CP +W WS C+VTCG+G R VLC
Sbjct: 408 IQGHVTSVEEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLCIDH 466
Query: 995 AGDHCDG----EKPESVRACQLP-PC 1015
G H G KP C +P PC
Sbjct: 467 RGMHTGGCSPKTKPHIKEECIVPTPC 492
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 230 bits (587), Expect = 5e-60
Identities = 165/513 (32%), Positives = 228/513 (44%), Gaps = 70/513 (13%)
Query: 548 QKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQK 607
++Q WG W+++ CSRTCG GV FR R C + +GG C G ++ C TE C
Sbjct: 23 RRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRR-DGGSSCVGPARSHRSCRTESCPD 81
Query: 608 HFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDG 667
DFRA+QC + + E+Q ++ WLPY + P K C L C K ++ V DG
Sbjct: 82 GARDFRAEQCAEFDGA-EFQGRRYRWLPY-YSAPNK-CELNCIPKGENFYYKHREAVVDG 138
Query: 668 THCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLG 727
T C +CV G C VGCD E+ S+K EDKC CGGD + C V GTF
Sbjct: 139 TPCE-PGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF-------- 189
Query: 728 YLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKG--EEAKSRTFIDLGVEWD 785
+A+ A+KN G Y LNG E A++ + ++
Sbjct: 190 -------------------DANDLSRAVKN-VRGEYYLNGHWTIEAARALPAASTILHYE 229
Query: 786 YNIEDDI--ESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEE 843
E D+ E LH GP +P+++ +I QE + Y+Y + ++
Sbjct: 230 RGAEGDLAPERLHARGPTSEPLVIELISQE--PNPGVHYEYHL------------PLRRP 275
Query: 844 LDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQE 903
F W+ SWS CS CGGG Q C D++ C+ +P RR CN+
Sbjct: 276 SPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRPAD-RRSCNLHP 332
Query: 904 CTH-PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG--DRPESRRP 960
C W A W C+ +CG G Q R+V C+ G +V C G +P + +
Sbjct: 333 CPETKRWKAGPWAPCSASCG-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQA 391
Query: 961 CNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVR--ACQLPPCNDE 1018
CN C A W PW ECSV+CG G R V CR GE+ + AC L D
Sbjct: 392 CNLQRC-AAWSPEPWGECSVSCGVGVRKRSVTCR------GERGSLLHTAACSL---EDR 441
Query: 1019 PCLGDKSIFCQMEVLARYCSIPGYNKLCCESCS 1051
P L + + +L+ G LC +SCS
Sbjct: 442 PPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCS 474
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 214 bits (545), Expect = 4e-55
Identities = 146/486 (30%), Positives = 213/486 (43%), Gaps = 62/486 (12%)
Query: 546 NQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEEC 605
+ + +DGNW +W + CSRTCG G + R+C G++C G N Y+ C+ +C
Sbjct: 70 SDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDC 123
Query: 606 QKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVH 665
EDFRAQQC N +YQ + WLP + DP C L C ++ V + V
Sbjct: 124 PPDAEDFRAQQCSAYND-VQYQGHYYEWLP-RYNDPAAPCALKCHAQGQNLVVELAPKVL 181
Query: 666 DGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTR--TP 723
DGT C+ D +C+ G C VGCD+++GSN ED CGVC GD S CR V+G +P
Sbjct: 182 DGTRCN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSP 240
Query: 724 RKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEA--KSRTFIDLG 781
K + +P G+R V I P L I+++ + KGE + F+
Sbjct: 241 EKREE-NVIAVPLGSRSVRI--TVKGPAHLFIESKT----LQGSKGEHSFNSPGVFLVEN 293
Query: 782 VEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQ 841
++ + ++ GPL I +Y +DSV I
Sbjct: 294 TTVEFQRGSERQTFKIPGPLMADFI-------------FKTRYTAAKDSVVQFFFYQPI- 339
Query: 842 EELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCE---ANKKPKPIRRM 898
+ +W + C+ CGGG+Q C ++V +C N KPKP +
Sbjct: 340 ----SHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKE 395
Query: 899 CNIQECTH----------------PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTN 942
C++ C P W W C+ +CG G Q R+ C++ + G
Sbjct: 396 CSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEI 454
Query: 943 RSVHSKYCM-GDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC--RAGDHC 999
V CM +P+ + CN CP +W WS+C+VTCG G R VLC G+H
Sbjct: 455 LQVEEWKCMYAPKPKVMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV 513
Query: 1000 DGEKPE 1005
G P+
Sbjct: 514 GGCNPQ 519
Score = 105 bits (262), Expect = 3e-22
Identities = 57/191 (29%), Positives = 84/191 (43%), Gaps = 17/191 (8%)
Query: 846 TFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECT 905
T++W ++ C+ C GG Q C + V+ S C+ +P + + CN + C
Sbjct: 645 TYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCP 704
Query: 906 HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVP 965
P W W C+ TCG G Q R V CL P + C ++P + + CN+
Sbjct: 705 -PRWHVGSWGPCSATCG-VGIQTRDVYCLHP----GETPAPPEECRDEKPHALQACNQFD 758
Query: 966 CPAQWKTGPWSECSVTCGEGTEVRQVLCR-----------AGDHCDGEKPESVRACQLPP 1014
CP W W +CS TCG GT+ R+V CR + + C G K S ++C
Sbjct: 759 CPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTD 818
Query: 1015 CNDEPCLGDKS 1025
C +GD S
Sbjct: 819 CPPHLAVGDWS 829
Score = 102 bits (254), Expect = 2e-21
Identities = 60/180 (33%), Positives = 85/180 (47%), Gaps = 17/180 (9%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
W + SW CS CG G Q C + C ++KP ++ CN +C P
Sbjct: 707 WHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEE-CR-DEKPHALQA-CNQFDCP-PG 762
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPA 968
W EEW+ C++TCG G Q R V C Q L DG+ ++ + C G + S + C R CP
Sbjct: 763 WHIEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 821
Query: 969 QWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPES------------VRACQLPPCN 1016
G WS+CSV+CG G + R+ +C+ P S VR+CQ+P C+
Sbjct: 822 HLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECS 881
Score = 97.4 bits (241), Expect = 7e-20
Identities = 83/296 (28%), Positives = 115/296 (38%), Gaps = 73/296 (24%)
Query: 823 KYIIHEDSVPTINSNNVIQEE--LDTFEWALKSWSQCSKPCGG-GFQYTKYGCRRKSDNK 879
KYI+ + T NSN+ E + F W +WS CS CG G + + C ++ +
Sbjct: 1402 KYILQATNTRT-NSNDPTGEPPPQEPF-WEPGNWSHCSATCGHLGARIQRPQCVM-ANGQ 1458
Query: 880 MVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLD 939
V + C+ +KP CNI++C W W C+ +CG GY R V C + +
Sbjct: 1459 EVSEALCDHLQKPLAGFEPCNIRDCP-ARWFTSVWSQCSVSCGE-GYHSRQVTCKRTKAN 1516
Query: 940 GTNRSVHSKYCMG-DRPESRRPC-----------NRVP---------------------- 965
GT + V + C DRP R+PC NR P
Sbjct: 1517 GTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSS 1576
Query: 966 --------------------CPAQWKTGPWSECSVTCGEGTEVRQVLC--------RAGD 997
C W TGPW C+ CG G + R+V C A
Sbjct: 1577 DSNCDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKR 1636
Query: 998 HC-DGEKPESVRACQLPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSK 1052
HC +KP S R C P C D C D + +C CS+ Y + CC+SC +
Sbjct: 1637 HCVQKKKPISWRHCLGPSC-DRDCT-DTTHYCMFVKHLNLCSLDRYKQRCCQSCQE 1690
Score = 79.0 bits (193), Expect = 3e-14
Identities = 58/194 (29%), Positives = 80/194 (41%), Gaps = 39/194 (20%)
Query: 854 WSQCSKPCGGGFQYTKYGCR-----RKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
WS CS CG G Q + CR +++ ++ CE K P R C ++ C
Sbjct: 573 WSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEE-CEGPKLPT--ERPCLLEACDESP 629
Query: 909 WVAE-------------EWEH-----CTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC 950
E +WE+ CT TC G+Q CL T ++V+ C
Sbjct: 630 ASRELDIPLPEDSETTYDWEYAGFTPCTATC-VGGHQEAIAVCLHIQ---TQQTVNDSLC 685
Query: 951 -MGDRPESR-RPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC-------RAGDHCDG 1001
M RP + + CN PCP +W G W CS TCG G + R V C + C
Sbjct: 686 DMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD 745
Query: 1002 EKPESVRACQLPPC 1015
EKP +++AC C
Sbjct: 746 EKPHALQACNQFDC 759
Score = 58.9 bits (141), Expect = 3e-08
Identities = 67/290 (23%), Positives = 101/290 (34%), Gaps = 73/290 (25%)
Query: 845 DTFEWALKSWSQCSKPCGGGFQYTKYGC---------------RRKSDNKMVHRSFCEAN 889
D +W WSQC+ CG G +Y C + + V C
Sbjct: 478 DCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKP 537
Query: 890 KKPKPI-------RRMCNIQECT----HPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPL- 937
K+ P+ ++ ++E P ++ E W C+ TCG G Q+R V+C L
Sbjct: 538 KEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCG-PGVQVREVKCRVLLT 596
Query: 938 LDGTNRSVHSKYCMGDRPESRRPCNRVPC---PA----------------QWKTGPWSEC 978
T + + C G + + RPC C PA W+ ++ C
Sbjct: 597 FTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPC 656
Query: 979 SVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQL---PP-----CNDEPC--------LG 1022
+ TC G + +C H ++ + C + PP CN EPC G
Sbjct: 657 TATCVGGHQEAIAVCL---HIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWG 713
Query: 1023 DKSIFCQMEVLAR--YCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHD 1070
S C + + R YC PG E C P+ L+A D
Sbjct: 714 PCSATCGVGIQTRDVYCLHPGETPAPPEECRDEK-----PHALQACNQFD 758
Score = 32.3 bits (72), Expect = 2.8
Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 5/67 (7%)
Query: 555 GSWTKFGSCSRTCGTGVRFRTRQCNNP--MPINGGQDCPGVNFEYQLCNTEECQKHFEDF 612
GSW G CS TCG G++ R C +P P + Q CN +C +
Sbjct: 710 GSW---GPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIE 766
Query: 613 RAQQCQQ 619
QQC +
Sbjct: 767 EWQQCSR 773
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 185 bits (469), Expect = 3e-46
Identities = 146/490 (29%), Positives = 211/490 (43%), Gaps = 53/490 (10%)
Query: 564 SRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSH 623
S G G T+ + P + C G +Y+LCNT C + R QC N+
Sbjct: 266 SNNHGVGTHGATQSFSQPAR-STAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
Query: 624 FEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGE 683
+ + W P+ ++C L CQ+ + V DGT C ++ +ICV G+
Sbjct: 325 -PFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCD-QNGTAICVSGQ 382
Query: 684 CVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLI 743
C +GCD +GS+KV DKCGVCGGDN+ C+ V G F LGY ++ +IP GA + I
Sbjct: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
Query: 744 QEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDI-----ESLHTD 798
E S + LA++++ +G I+NG + + G + Y ++I ES +
Sbjct: 443 TEMYKSNNYLALRSR-SGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAE 501
Query: 799 GPLHDPVIVLIIPQENDTRSSLTYKYIIH-----EDSVPTIN------SNNVIQEELDTF 847
GP ++ + V +I Q+ + Y+Y+I VP + ++ E
Sbjct: 502 GPTNEILDVYMIHQQ--PNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQE 559
Query: 848 EWALKSWSQCSKPCGGGF--QYTKYGCR----RKSDNKMVHRSFCEANKKPKPIRRMCNI 901
E K ++ + G +T + R D HR P+P RR +
Sbjct: 560 EGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDH 619
Query: 902 QECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC---MGDRPESR 958
W C+ TCG G Q RC+ T+ YC M PE
Sbjct: 620 N------WKQLGTTECSTTCG-KGSQYPIFRCVH---RSTHEEAPESYCDSSMKPTPE-E 668
Query: 959 RPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR----------AGDHCDG-EKPESV 1007
PCN PCPA W G WSECS TCG G + RQVLCR C EKPE+
Sbjct: 669 EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETT 728
Query: 1008 RACQLPPCND 1017
CQL C++
Sbjct: 729 STCQLKICSE 738
Score = 97.8 bits (242), Expect = 5e-20
Identities = 69/215 (32%), Positives = 96/215 (44%), Gaps = 16/215 (7%)
Query: 849 WALKSWSQ-CSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
W L WS+ CS CG G + C + + C N+ + C+ CT
Sbjct: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG-CGNNRPAEATP--CDNGPCTGK 853
Query: 908 L-WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPC 966
+ W A W C+ CGS G Q R V C++ D S+ ++P S++ C+ PC
Sbjct: 854 VEWFAGSWSQCSIECGS-GTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
Query: 967 PAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH-----CDGE-KPESVRACQLPPC---ND 1017
A+W + WS CS +C G VR+V C + D CD + KPE +C C D
Sbjct: 913 GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVPEVD 972
Query: 1018 EPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSK 1052
E C DK C + V AR C Y CC SC++
Sbjct: 973 ENC-KDKYYNCNVVVQARLCVYNYYKTACCASCTR 1006
Score = 97.1 bits (240), Expect = 9e-20
Identities = 61/192 (31%), Positives = 83/192 (43%), Gaps = 12/192 (6%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
W ++CS CG G QY + C +S ++ S+C+++ KP P CNI C
Sbjct: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCP-AF 679
Query: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCP 967
W EW C+KTCG G Q R V C Q + + +V C ++PE+ C C
Sbjct: 680 WDIGEWSECSKTCG-LGMQHRQVLCRQ-VYANRSLTVQPYRCQHLEKPETTSTCQLKICS 737
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLC--RAGDHCDGE------KPESVRACQLPPCNDEP 1019
W+ CSV CG G R V C GD D E +P + C + PC
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSW 797
Query: 1020 CLGDKSIFCQME 1031
L + S C E
Sbjct: 798 FLTEWSERCSAE 809
Score = 89.7 bits (221), Expect = 1e-17
Identities = 59/185 (31%), Positives = 88/185 (47%), Gaps = 27/185 (14%)
Query: 848 EWALKS-WSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
EW +++ W+ CS PCG G + C + +V C +P I C++ C
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD-VVDDEECNMKLRPNDIEN-CDMGPCAK 795
Query: 907 PLWVAEEW-EHCTKTCGSSGYQLRTVRCLQPLLDGTNR--SVHSKYCMGDRPESRRPCNR 963
W EW E C+ CG +G + R+V C+ TN S+ + C +RP PC+
Sbjct: 796 S-WFLTEWSERCSAECG-AGVRTRSVVCM------TNHVSSLPLEGCGNNRPAEATPCDN 847
Query: 964 VPC--PAQWKTGPWSECSVTCGEGTEVRQVLC--RAGDHCDG---------EKPESVRAC 1010
PC +W G WS+CS+ CG GT+ R+V+C + D + EKP S ++C
Sbjct: 848 GPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSC 907
Query: 1011 QLPPC 1015
L PC
Sbjct: 908 HLKPC 912
Score = 36.6 bits (83), Expect = 0.15
Identities = 16/38 (42%), Positives = 22/38 (57%), Gaps = 1/38 (2%)
Query: 552 GNWGSWTKFGSCSRTCGTGVRFRTRQC-NNPMPINGGQ 588
G WG+W + +CSR+C GV +TR C + GGQ
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPCLPRSYRLRGGQ 91
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 180 bits (456), Expect = 8e-45
Identities = 150/505 (29%), Positives = 201/505 (39%), Gaps = 74/505 (14%)
Query: 590 CPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYC 649
C G + + + C+ C D RA QC NS E+ + W P+ +RC L C
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQ-EFMGQLYQWEPFTEVQGSQRCELNC 422
Query: 650 QSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDN 709
+ + + V DGT C P ICV G C+ GCD +GS + D CGVCGGD+
Sbjct: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 710 SHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKG 769
S CR V G T LGY K+ IP GA + I + S + LA++ G I+NG
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
Query: 770 EEAKSRTFIDLGVEWDYN----IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYI 825
++ G + YN E ESL +GP PV V +I QE + + Y+Y+
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEEN--PGVFYQYV 598
Query: 826 IHEDSVPTINSNNV-------IQEELDTFE------------------------------ 848
I S P I N +Q E+ E
Sbjct: 599 I--SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPH 656
Query: 849 -----------WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR 897
W S CS CG G + C + + + C A +P
Sbjct: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
Query: 898 MCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPE 956
C+ C P W A EW C+++CG G Q R ++C Q G SV + C RP
Sbjct: 717 PCHGTPCP-PYWEAGEWTSCSRSCG-PGTQHRQLQCRQE-FGGGGSSVPPERCGHLPRPN 773
Query: 957 SRRPCNRVPCPAQWKTG-PWSECSVTCGEGTEVRQVLC--RAGDHCDGE-------KPES 1006
+ C C W+ G PWS+CSV CG G RQV C GD + +P S
Sbjct: 774 ITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
Query: 1007 VRACQLPPCNDEPCLGDKSIFCQME 1031
AC + PC D S C E
Sbjct: 833 REACDMGPCTTAWFHSDWSSKCSAE 857
Score = 102 bits (253), Expect = 3e-21
Identities = 67/224 (29%), Positives = 92/224 (41%), Gaps = 20/224 (8%)
Query: 846 TFEWALKSWS-QCSKPCGGGFQYTKYGCRR--------KSDNKMVHRSFCEANKKPKPIR 896
T W WS +CS CG G Q C + + C +P P
Sbjct: 842 TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRP-PDM 900
Query: 897 RMCNIQECTHPL-WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRP 955
R C++ C W W C+ CGS G Q R + C+ L N + S RP
Sbjct: 901 RACSLGPCERTWRWYTGPWGECSSECGS-GTQRRDIICVSKLGTEFNVTSPSNCSHLPRP 959
Query: 956 ESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEK-PESVRACQLPP 1014
+ +PC C +W + PWS CS +C GT+ R+V C + + + P +R + P
Sbjct: 960 PALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRP 1019
Query: 1015 CNDEPC-------LGDKSIFCQMEVLARYCSIPGYNKLCCESCS 1051
CN +PC D S C + V AR C P Y CC SC+
Sbjct: 1020 CNSQPCSQRPDDQCKDSSPHCPLVVQARLCVYPYYTATCCRSCA 1063
Score = 87.0 bits (214), Expect = 1e-16
Identities = 67/231 (29%), Positives = 97/231 (41%), Gaps = 21/231 (9%)
Query: 849 WALKS-WSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
W + S WSQCS CG G + + C + +++ + C + P R C++ CT
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE-CASGPPQPPSREACDMGPCT-T 843
Query: 908 LWVAEEW-EHCTKTCGSSGYQLRTVRC------LQPLLDGTNRSVHSKYCMGDRPESRRP 960
W +W C+ CG +G Q R+V C L P G RP R
Sbjct: 844 AWFHSDWSSKCSAECG-TGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRA 902
Query: 961 CNRVPCPAQWK--TGPWSECSVTCGEGTEVRQVLC--RAGDHCDGEKPESV----RACQL 1012
C+ PC W+ TGPW ECS CG GT+ R ++C + G + P + R L
Sbjct: 903 CSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPAL 962
Query: 1013 PPCNDEPCLGDKSIFCQMEVLARYCSIPGYNK-LCCESCSKRSSTLPPPYL 1062
PC + C D+ +R C + + C S ++ ST PP L
Sbjct: 963 QPCQGQAC-QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQL 1012
Score = 42.7 bits (99), Expect = 0.002
Identities = 16/34 (47%), Positives = 22/34 (64%)
Query: 548 QKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNP 581
Q +G WG W ++ SCS+ CG GV+ R+R C P
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 35.0 bits (79), Expect = 0.43
Identities = 38/138 (27%), Positives = 51/138 (36%), Gaps = 36/138 (26%)
Query: 466 PKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPC-KQLWCSHPDNPYFC--KTKKGP 522
P++P P + + VG+ C+A C K +W P F + G
Sbjct: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSA-----SCGKGVW-----RPIFLCISRESGE 698
Query: 523 PLDGTECAAG-------KWCYKGHC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRF 573
LD CAAG + C+ C W+ G WT SCSR+CG G +
Sbjct: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA----------GEWT---SCSRSCGPGTQH 745
Query: 574 RTRQCNNPMPINGGQDCP 591
R QC GG P
Sbjct: 746 RQLQCRQEFG-GGGSSVP 762
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 178 bits (452), Expect = 2e-44
Identities = 146/489 (29%), Positives = 197/489 (40%), Gaps = 74/489 (15%)
Query: 590 CPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYC 649
C G + + + C+ C D RA QC NS E+ + W P+ +RC L C
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQ-EFMGQLYQWEPFTEVQGSQRCELNC 422
Query: 650 QSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDN 709
+ + + V DGT C P ICV G C+ GCD +GS + D CGVCGGD+
Sbjct: 423 RPRGFRFYVRHTEKVQDGTLCQPGAP-DICVAGRCLSPGCDGILGSGRRPDGCGVCGGDD 481
Query: 710 SHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKG 769
S CR V G T LGY K+ IP GA + I + S + LA++ G I+NG
Sbjct: 482 STCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPG-GRSIINGNW 540
Query: 770 EEAKSRTFIDLGVEWDYN----IEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYI 825
++ G + YN E ESL +GP PV V +I QE + + Y+Y+
Sbjct: 541 AVDPPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEEN--PGVFYQYV 598
Query: 826 IHEDSVPTINSNNV-------IQEELDTFE------------------------------ 848
I S P I N +Q E+ E
Sbjct: 599 I--SSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPH 656
Query: 849 -----------WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR 897
W S CS CG G + C + + + C A +P
Sbjct: 657 PRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPE 716
Query: 898 MCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPE 956
C+ C P W A EW C+++CG G Q R ++C Q G SV + C RP
Sbjct: 717 PCHGTPCP-PYWEAGEWTSCSRSCG-PGTQHRQLQCRQE-FGGGGSSVPPERCGHLPRPN 773
Query: 957 SRRPCNRVPCPAQWKTG-PWSECSVTCGEGTEVRQVLC--RAGDHCDGE-------KPES 1006
+ C C W+ G PWS+CSV CG G RQV C GD + +P S
Sbjct: 774 ITQSCQLRLC-GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
Query: 1007 VRACQLPPC 1015
AC + PC
Sbjct: 833 REACDMGPC 841
Score = 60.8 bits (146), Expect = 7e-09
Identities = 41/134 (30%), Positives = 57/134 (42%), Gaps = 15/134 (11%)
Query: 849 WALKSWSQCSKPCGGGFQYTKYGCRRK--SDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
W W+ CS+ CG G Q+ + CR++ V C +P I + C ++ C H
Sbjct: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGH 785
Query: 907 PLW-VAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRS-VHSKYCMGDRPE--SRRPCN 962
W V W C+ CG G + R VRC+ G N V + C P+ SR C+
Sbjct: 786 --WEVGSPWSQCSVRCGR-GQRSRQVRCV-----GNNGDEVSEQECASGPPQPPSREACD 837
Query: 963 RVPCPAQWKTGPWS 976
PC W WS
Sbjct: 838 MGPCTTAWFHSDWS 851
Score = 42.7 bits (99), Expect = 0.002
Identities = 16/34 (47%), Positives = 22/34 (64%)
Query: 548 QKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNP 581
Q +G WG W ++ SCS+ CG GV+ R+R C P
Sbjct: 41 QGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 35.0 bits (79), Expect = 0.43
Identities = 38/138 (27%), Positives = 51/138 (36%), Gaps = 36/138 (26%)
Query: 466 PKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPC-KQLWCSHPDNPYFC--KTKKGP 522
P++P P + + VG+ C+A C K +W P F + G
Sbjct: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSA-----SCGKGVW-----RPIFLCISRESGE 698
Query: 523 PLDGTECAAG-------KWCYKGHC--MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRF 573
LD CAAG + C+ C W+ G WT SCSR+CG G +
Sbjct: 699 ELDERSCAAGARPPASPEPCHGTPCPPYWEA----------GEWT---SCSRSCGPGTQH 745
Query: 574 RTRQCNNPMPINGGQDCP 591
R QC GG P
Sbjct: 746 RQLQCRQEFG-GGGSSVP 762
Score = 34.7 bits (78), Expect = 0.56
Identities = 19/55 (34%), Positives = 25/55 (45%)
Query: 968 AQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLG 1022
A WK S CS +CG+G LC + + + S A PP + EPC G
Sbjct: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHG 720
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,447,636
Number of Sequences: 37866
Number of extensions: 2741743
Number of successful extensions: 7945
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 55
Number of HSP's that attempted gapping in prelim test: 6365
Number of HSP's gapped (non-prelim): 706
length of query: 1205
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1091
effective length of database: 13,930,794
effective search space: 15198496254
effective search space used: 15198496254
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.