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Search of human proteins with 21237765
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21237765 MAP kinase-activated protein kinase 5 isoform 1
[Homo sapiens]
(471 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Hom... 949 0.0
gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Hom... 944 0.0
gi|32481209 mitogen-activated protein kinase-activated protein k... 277 1e-74
gi|4758700 mitogen-activated protein kinase-activated protein ki... 263 2e-70
gi|10863901 mitogen-activated protein kinase-activated protein k... 259 4e-69
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 198 8e-51
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 181 1e-45
gi|40018627 MAP kinase-interacting serine/threonine kinase 2 iso... 180 3e-45
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 177 1e-44
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 177 1e-44
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 177 2e-44
gi|40018631 MAP kinase-interacting serine/threonine kinase 2 iso... 177 2e-44
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 175 7e-44
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 175 7e-44
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 174 1e-43
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 174 2e-43
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 174 2e-43
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 172 5e-43
gi|207113186 MAP kinase-interacting serine/threonine kinase 1 is... 171 2e-42
gi|212549753 calcium/calmodulin-dependent protein kinase II delt... 170 2e-42
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 170 3e-42
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 170 3e-42
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 169 4e-42
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 169 4e-42
gi|212549756 calcium/calmodulin-dependent protein kinase II delt... 168 9e-42
gi|26667183 calcium/calmodulin-dependent protein kinase II delta... 168 9e-42
gi|26667186 calcium/calmodulin-dependent protein kinase II delta... 168 9e-42
gi|26667189 calcium/calmodulin-dependent protein kinase II delta... 168 9e-42
gi|26667180 calcium/calmodulin-dependent protein kinase II delta... 168 9e-42
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 167 2e-41
>gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Homo
sapiens]
Length = 471
Score = 949 bits (2454), Expect = 0.0
Identities = 471/471 (100%), Positives = 471/471 (100%)
Query: 1 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR 60
MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
Sbjct: 1 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR 60
Query: 61 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 120
NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
Sbjct: 61 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 120
Query: 121 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL 180
TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
Sbjct: 121 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL 180
Query: 181 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP 240
MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
Sbjct: 181 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP 240
Query: 241 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD 300
FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
Sbjct: 241 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD 300
Query: 301 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL 360
HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
Sbjct: 301 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL 360
Query: 361 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA 420
RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA
Sbjct: 361 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGENEDEKLNEVMQEA 420
Query: 421 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ 471
WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
Sbjct: 421 WKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ 471
>gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Homo
sapiens]
Length = 473
Score = 944 bits (2441), Expect = 0.0
Identities = 471/473 (99%), Positives = 471/473 (99%), Gaps = 2/473 (0%)
Query: 1 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR 60
MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR
Sbjct: 1 MSEESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR 60
Query: 61 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 120
NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF
Sbjct: 61 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 120
Query: 121 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL 180
TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL
Sbjct: 121 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDL 180
Query: 181 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP 240
MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP
Sbjct: 181 MTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPP 240
Query: 241 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD 300
FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD
Sbjct: 241 FYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD 300
Query: 301 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL 360
HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL
Sbjct: 301 HPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPIL 360
Query: 361 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQA--GENEDEKLNEVMQ 418
RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQA GENEDEKLNEVMQ
Sbjct: 361 RKRKLLGTKPKDSVYIHDHENGAEDSNVALEKLRDVIAQCILPQAGKGENEDEKLNEVMQ 420
Query: 419 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ 471
EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ
Sbjct: 421 EAWKYNRECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIEEQTTSHESQ 473
>gi|32481209 mitogen-activated protein kinase-activated protein
kinase 2 isoform 2 [Homo sapiens]
Length = 400
Score = 277 bits (709), Expect = 1e-74
Identities = 153/360 (42%), Positives = 223/360 (61%), Gaps = 32/360 (8%)
Query: 11 IKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA 70
IK+ +I+++Y + +Q LG GI+G V K TQE+FALK+L D PKAR EV LH +
Sbjct: 54 IKKNAIIDDYKVT-SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS 112
Query: 71 THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQV 128
P+IV+I++V+ N + R LLIVME ++GGELF RI + FTE++AS++
Sbjct: 113 QCPHIVRIVDVYENLY------AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166
Query: 129 TKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFT 186
K I A+++ H +NIAHRD+KPENLL+ +A +KL DFGFAK L TP +T
Sbjct: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226
Query: 187 PYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHH 246
PYYVAP+VL P Y+KSCD+WSLGVI+Y++LCGYPPFYS +H
Sbjct: 227 PYYVAPEVL------------------GPEKYDKSCDMWSLGVIMYILLCGYPPFYS-NH 267
Query: 247 SRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW-LN 305
I M+ +I G +EFP EWS++SE K ++R LLK +P +R+TI ++HPW +
Sbjct: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327
Query: 306 STEALDNVLPSAQLMM-DKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK 364
ST+ L +++++ DK +++ LA MR+ ++ +K + +NP+L KR+
Sbjct: 328 STKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRR 387
>gi|4758700 mitogen-activated protein kinase-activated protein
kinase 3 [Homo sapiens]
Length = 382
Score = 263 bits (673), Expect = 2e-70
Identities = 150/358 (41%), Positives = 218/358 (60%), Gaps = 31/358 (8%)
Query: 12 KETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCAT 71
K+ ++ ++Y ++ Q LG G++G V C + T ++ ALK+L D PKAR EV H +
Sbjct: 35 KKYAVTDDYQLS-KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASG 93
Query: 72 HPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQVT 129
P+IV I++V+ N H + LLI+ME MEGGELF RI + + FTE++A+++
Sbjct: 94 GPHIVCILDVYENM----HHG--KRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIM 147
Query: 130 KQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK-IDQGDLMTPQFTPY 188
+ I A++ H NIAHRD+KPENLL+ DA +KL DFGFAK Q L TP +TPY
Sbjct: 148 RDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPY 207
Query: 189 YVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSR 248
YVAP+VL P Y+KSCD+WSLGVI+Y++LCG+PPFYS + +
Sbjct: 208 YVAPEVLG------------------PEKYDKSCDMWSLGVIMYILLCGFPPFYS-NTGQ 248
Query: 249 TIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTE 308
I M+R+I G + FP EWS++SE AK ++R LLK P ERLTI ++HPW+N +
Sbjct: 249 AISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSM 308
Query: 309 ALDNV-LPSAQLMM-DKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK 364
+ L +A+++ DK +++ LA MR+ +V +K L + NN +L KR+
Sbjct: 309 VVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRR 366
>gi|10863901 mitogen-activated protein kinase-activated protein
kinase 2 isoform 1 [Homo sapiens]
Length = 370
Score = 259 bits (662), Expect = 4e-69
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 31/317 (9%)
Query: 11 IKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA 70
IK+ +I+++Y + +Q LG GI+G V K TQE+FALK+L D PKAR EV LH +
Sbjct: 54 IKKNAIIDDYKVT-SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRAS 112
Query: 71 THPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQV 128
P+IV+I++V+ N + R LLIVME ++GGELF RI + FTE++AS++
Sbjct: 113 QCPHIVRIVDVYENLY------AGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166
Query: 129 TKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQFT 186
K I A+++ H +NIAHRD+KPENLL+ +A +KL DFGFAK L TP +T
Sbjct: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226
Query: 187 PYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHH 246
PYYVAP+VL P Y+KSCD+WSLGVI+Y++LCGYPPFYS +H
Sbjct: 227 PYYVAPEVL------------------GPEKYDKSCDMWSLGVIMYILLCGYPPFYS-NH 267
Query: 247 SRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW-LN 305
I M+ +I G +EFP EWS++SE K ++R LLK +P +R+TI ++HPW +
Sbjct: 268 GLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327
Query: 306 STEALDNVLPSAQLMMD 322
ST+ L +++++ +
Sbjct: 328 STKVPQTPLHTSRVLKE 344
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 198 bits (504), Expect = 8e-51
Identities = 113/310 (36%), Positives = 170/310 (54%), Gaps = 36/310 (11%)
Query: 11 IKETSILEEYSINWTQK-LGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLHM 67
+K++ + Y ++ K LG G R CV K + + FA+KI+ R +A + E+
Sbjct: 414 MKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALK 473
Query: 68 MCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQ 127
+C HPNIV++ EVF + + +VME++ GGELF RI + +HF+E +AS
Sbjct: 474 LCEGHPNIVKLHEVFHDQLH----------TFLVMELLNGGELFERIKKKKHFSETEASY 523
Query: 128 VTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKI---DQGDLMTPQ 184
+ +++ A+ H H + + HRDLKPENLLF D + + +K+ DFGFA++ D L TP
Sbjct: 524 IMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC 583
Query: 185 FTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK 244
FT +Y AP++L Y++SCDLWSLGVI+Y ML G PF S
Sbjct: 584 FTLHYAAPELLNQN------------------GYDESCDLWSLGVILYTMLSGQVPFQSH 625
Query: 245 HHSRTIPK--DMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
S T ++ +KI G F F E W +S+ AKD+++ LL V P +RL + G+ +
Sbjct: 626 DRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNE 685
Query: 303 WLNSTEALDN 312
WL L +
Sbjct: 686 WLQDGSQLSS 695
Score = 97.1 bits (240), Expect = 3e-20
Identities = 80/278 (28%), Positives = 130/278 (46%), Gaps = 42/278 (15%)
Query: 28 LGAGISGPVRVCVKKS---TQERFALKIL-----LDRPKARNEVRLHMMCATHPNIVQII 79
LG G G V + K S T + +A+K+L + + K R T +++ I
Sbjct: 55 LGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTR------TERQVLEHI 108
Query: 80 EVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHC 139
V + +L ++++ + GGELF +SQ FTE + +I LAL H
Sbjct: 109 RQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHL 168
Query: 140 HLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMTPQF----TPYYVAPQVL 195
H L I +RD+K EN+L N V L DFG +K D + T Y+AP ++
Sbjct: 169 HKLGIIYRDIKLENILLDSN---GHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIV 225
Query: 196 EAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMR 255
SG ++K+ D WSLGV++Y +L G PF + + ++
Sbjct: 226 RG------GDSG----------HDKAVDWWSLGVLMYELLTGASPF-TVDGEKNSQAEIS 268
Query: 256 RKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERL 293
R+I+ +P+E +S +AKD++++LL P++RL
Sbjct: 269 RRILKSEPPYPQE----MSALAKDLIQRLLMKDPKKRL 302
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 181 bits (459), Expect = 1e-45
Identities = 116/328 (35%), Positives = 176/328 (53%), Gaps = 42/328 (12%)
Query: 3 EESDMDKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKAR-- 60
EE D K+T+ + + I + + LG+G V + ++ T + FALK + P R
Sbjct: 5 EEDDCSSWKKQTTNIRKTFI-FMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDS 63
Query: 61 ---NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH 117
NE+ + + H NIV + +++ ++ + +VM+++ GGELF RI +
Sbjct: 64 SLENEIAV-LKKIKHENIVTLEDIYESTTHY----------YLVMQLVSGGELFDRILER 112
Query: 118 RHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQ 177
+TEK AS V +Q+ A+++ H I HRDLKPENLL+ ++ + + DFG +K++Q
Sbjct: 113 GVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ 172
Query: 178 GDLM-TPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLC 236
+M T TP YVAP+VL AQ+ Y+K+ D WS+GVI Y++LC
Sbjct: 173 NGIMSTACGTPGYVAPEVL-AQK-----------------PYSKAVDCWSIGVITYILLC 214
Query: 237 GYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIE 296
GYPPFY + S+ + KI G +EF W ISE AKD + LL+ P ER T E
Sbjct: 215 GYPPFYEETESK-----LFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCE 269
Query: 297 GVLDHPWLNSTEALD-NVLPSAQLMMDK 323
L HPW++ AL ++ PS L + K
Sbjct: 270 KALSHPWIDGNTALHRDIYPSVSLQIQK 297
>gi|40018627 MAP kinase-interacting serine/threonine kinase 2
isoform 2 [Homo sapiens]
Length = 465
Score = 180 bits (456), Expect = 3e-45
Identities = 113/339 (33%), Positives = 171/339 (50%), Gaps = 49/339 (14%)
Query: 28 LGAGISGPVRVCVKKSTQERFALKILLDRP-----KARNEVRLHMMCATHPNIVQIIEVF 82
LG G V+ C+ T + +A+KI+ +P + EV + C H N++++IE F
Sbjct: 90 LGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFF 149
Query: 83 ANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLL 142
+F +V E M GG + I + RHF E +AS V + +A AL H
Sbjct: 150 EEEDRF----------YLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNK 199
Query: 143 NIAHRDLKPENLLFKDNSLDAPVKLCDFGF----------AKIDQGDLMTPQFTPYYVAP 192
IAHRDLKPEN+L + + +PVK+CDF + I +L+TP + Y+AP
Sbjct: 200 GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 259
Query: 193 QVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS----- 247
+V+EA E++ I Y+K CDLWSLGVI+Y++L GYPPF + S
Sbjct: 260 EVVEA----FSEEASI---------YDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWD 306
Query: 248 -----RTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ I G +EFP+++W+ IS AKD++ KLL ++RL+ VL HP
Sbjct: 307 RGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHP 366
Query: 303 WLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMR 341
W+ A +N LP+ ++ + + AE +A R
Sbjct: 367 WVQGC-APENTLPTPMVLQRNSCAKDLTSFAAEAIAMNR 404
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 177 bits (450), Expect = 1e-44
Identities = 115/350 (32%), Positives = 180/350 (51%), Gaps = 45/350 (12%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLHMMCATHPNIVQIIEVFA 83
+ +G G + CV K+T +A+K++ D+ K E+ + + HPNI+ + +V+
Sbjct: 431 ETIGVGSYSECKRCVHKATNMEYAVKVI-DKSKRDPSEEIEILLRYGQHPNIITLKDVYD 489
Query: 84 NSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLN 143
+ + +V E+M GGEL +I + + F+E++AS V I + + H
Sbjct: 490 DG----------KHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 539
Query: 144 IAHRDLKPENLLFKDNSLDAP-VKLCDFGFAK---IDQGDLMTPQFTPYYVAPQVLEAQR 199
+ HRDLKP N+L+ D S + +++CDFGFAK + G LMTP +T +VAP+VL+ Q
Sbjct: 540 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ- 598
Query: 200 RHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIM 259
Y++ CD+WSLG+++Y ML GY PF + P+++ +I
Sbjct: 599 -----------------GYDEGCDIWSLGILLYTMLAGYTPF--ANGPSDTPEEILTRIG 639
Query: 260 TGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQL 319
+G F W+ +SE AKD+V K+L V P +RLT + VL HPW+ + LP +QL
Sbjct: 640 SGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDK----LPQSQL 695
Query: 320 M-MDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGT 368
D +V G A L + + LKP+ S R RKL T
Sbjct: 696 SHQDLQLVKGAMAATYSALNSSKPTP---QLKPIESSILAQRRVRKLPST 742
Score = 94.7 bits (234), Expect = 2e-19
Identities = 81/279 (29%), Positives = 125/279 (44%), Gaps = 54/279 (19%)
Query: 28 LGAGISGPV---RVCVKKSTQERFALKILLDRP-KARNEVRLHM-----MCATHPNIVQI 78
LG G G V R + + +A+K+L K R+ VR M HP +V++
Sbjct: 77 LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVVKL 136
Query: 79 IEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRH 138
F +L ++++ + GG+LF R+S+ FTE+ ++AL L H
Sbjct: 137 HYAFQTE----------GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALGLDH 186
Query: 139 CHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQF--TPYYVAPQV 194
H L I +RDLKPEN+L + + +KL DFG +K ID + F T Y+AP+V
Sbjct: 187 LHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKEAIDH-EKKAYSFCGTVEYMAPEV 242
Query: 195 LEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDM 254
+ Q ++ S D WS GV+++ ML G PF K T+ +
Sbjct: 243 VNRQ------------------GHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL 284
Query: 255 RRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERL 293
+ K+ F +S A+ ++R L K P RL
Sbjct: 285 KAKLGMPQF---------LSTEAQSLLRALFKRNPANRL 314
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 177 bits (450), Expect = 1e-44
Identities = 115/350 (32%), Positives = 180/350 (51%), Gaps = 45/350 (12%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLHMMCATHPNIVQIIEVFA 83
+ +G G + CV K+T +A+K++ D+ K E+ + + HPNI+ + +V+
Sbjct: 422 ETIGVGSYSECKRCVHKATNMEYAVKVI-DKSKRDPSEEIEILLRYGQHPNIITLKDVYD 480
Query: 84 NSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLN 143
+ + +V E+M GGEL +I + + F+E++AS V I + + H
Sbjct: 481 DG----------KHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQG 530
Query: 144 IAHRDLKPENLLFKDNSLDAP-VKLCDFGFAK---IDQGDLMTPQFTPYYVAPQVLEAQR 199
+ HRDLKP N+L+ D S + +++CDFGFAK + G LMTP +T +VAP+VL+ Q
Sbjct: 531 VVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ- 589
Query: 200 RHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIM 259
Y++ CD+WSLG+++Y ML GY PF + P+++ +I
Sbjct: 590 -----------------GYDEGCDIWSLGILLYTMLAGYTPF--ANGPSDTPEEILTRIG 630
Query: 260 TGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQL 319
+G F W+ +SE AKD+V K+L V P +RLT + VL HPW+ + LP +QL
Sbjct: 631 SGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDK----LPQSQL 686
Query: 320 M-MDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRKLLGT 368
D +V G A L + + LKP+ S R RKL T
Sbjct: 687 SHQDLQLVKGAMAATYSALNSSKPTP---QLKPIESSILAQRRVRKLPST 733
Score = 95.1 bits (235), Expect = 1e-19
Identities = 85/311 (27%), Positives = 134/311 (43%), Gaps = 70/311 (22%)
Query: 12 KETSILEEYSINWTQKLGAGISGP-------------------VRVCVKKSTQERFALKI 52
K+ +L+E SI K G+ + P VR + + +A+K+
Sbjct: 36 KDEGVLKEISITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKV 95
Query: 53 LLDRP-KARNEVRLHM-----MCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMME 106
L K R+ VR M HP +V++ F +L ++++ +
Sbjct: 96 LKKATLKVRDRVRTKMERDILADVNHPFVVKLHYAFQTE----------GKLYLILDFLR 145
Query: 107 GGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVK 166
GG+LF R+S+ FTE+ ++AL L H H L I +RDLKPEN+L + + +K
Sbjct: 146 GGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDE---EGHIK 202
Query: 167 LCDFGFAK--IDQGDLMTPQF--TPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSC 222
L DFG +K ID + F T Y+AP+V+ Q ++ S
Sbjct: 203 LTDFGLSKEAIDH-EKKAYSFCGTVEYMAPEVVNRQ------------------GHSHSA 243
Query: 223 DLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVR 282
D WS GV+++ ML G PF K T+ ++ K+ F +S A+ ++R
Sbjct: 244 DWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF---------LSTEAQSLLR 294
Query: 283 KLLKVKPEERL 293
L K P RL
Sbjct: 295 ALFKRNPANRL 305
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 177 bits (449), Expect = 2e-44
Identities = 108/310 (34%), Positives = 167/310 (53%), Gaps = 38/310 (12%)
Query: 10 AIKETSILEEYSINWTQK-LGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLH 66
A+ ++++++Y ++ + LG G R C ++ + + FA+KIL R +A + EV
Sbjct: 392 AVARSAMMQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAAL 451
Query: 67 MMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQAS 126
+C +HPN+V + EV + + +V+E++ GGEL I + RHF+E +AS
Sbjct: 452 RLCQSHPNVVNLHEVHHDQLH----------TYLVLELLRGGELLEHIRKKRHFSESEAS 501
Query: 127 QVTKQIALALRHCHL-LNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGD----LM 181
Q+ + + A+ H + HRDLKPEN+L+ D++ APVK+ DFGFA++ +
Sbjct: 502 QILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQ 561
Query: 182 TPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPF 241
TP FT Y AP++L Q Y++SCDLWSLGVI+Y+ML G PF
Sbjct: 562 TPCFTLQYAAPELLAQQ------------------GYDESCDLWSLGVILYMMLSGQVPF 603
Query: 242 Y--SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVL 299
S ++ ++ KI G F E W +SE AK++VR LL V P +RL +EG+
Sbjct: 604 QGASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLR 663
Query: 300 DHPWLNSTEA 309
WL A
Sbjct: 664 GSSWLQDGSA 673
Score = 92.8 bits (229), Expect = 6e-19
Identities = 84/336 (25%), Positives = 150/336 (44%), Gaps = 59/336 (17%)
Query: 1 MSEESDMDKAIKETSILEEYSINWTQK-----------LGAGISGPVRVCVKKSTQER-- 47
M +E D + E I E +K LG G G V + K +
Sbjct: 1 MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
Query: 48 -FALKIL-----LDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIV 101
+A+K+L + R K + R T ++++++ V + A+L ++
Sbjct: 61 LYAMKVLRKAALVQRAKTQEHTR------TERSVLELVRQAPFLVTLHYAFQTDAKLHLI 114
Query: 102 MEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSL 161
++ + GGE+F + Q ++F E + +I LAL H H L I +RDLK EN+L
Sbjct: 115 LDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDS--- 171
Query: 162 DAPVKLCDFGFAK--IDQGDLMTPQF--TPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT 217
+ + L DFG +K + + T F T Y+AP+++ ++ H
Sbjct: 172 EGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGH---------------- 215
Query: 218 YNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMA 277
K+ D WSLG++++ +L G PF + R ++ R+I+ S FP +I +A
Sbjct: 216 -GKAVDWWSLGILLFELLTGASPF-TLEGERNTQAEVSRRILKCSPPFP----PRIGPVA 269
Query: 278 KDVVRKLLKVKPEERL-----TIEGVLDHPWLNSTE 308
+D++++LL P++RL + V +HP+ +
Sbjct: 270 QDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
>gi|40018631 MAP kinase-interacting serine/threonine kinase 2
isoform 1 [Homo sapiens]
Length = 414
Score = 177 bits (448), Expect = 2e-44
Identities = 109/318 (34%), Positives = 164/318 (51%), Gaps = 49/318 (15%)
Query: 28 LGAGISGPVRVCVKKSTQERFALKILLDRP-----KARNEVRLHMMCATHPNIVQIIEVF 82
LG G V+ C+ T + +A+KI+ +P + EV + C H N++++IE F
Sbjct: 90 LGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFF 149
Query: 83 ANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLL 142
+F +V E M GG + I + RHF E +AS V + +A AL H
Sbjct: 150 EEEDRF----------YLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNK 199
Query: 143 NIAHRDLKPENLLFKDNSLDAPVKLCDFGF----------AKIDQGDLMTPQFTPYYVAP 192
IAHRDLKPEN+L + + +PVK+CDF + I +L+TP + Y+AP
Sbjct: 200 GIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAP 259
Query: 193 QVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS----- 247
+V+EA E++ I Y+K CDLWSLGVI+Y++L GYPPF + S
Sbjct: 260 EVVEA----FSEEASI---------YDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWD 306
Query: 248 -----RTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ I G +EFP+++W+ IS AKD++ KLL ++RL+ VL HP
Sbjct: 307 RGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHP 366
Query: 303 WLNSTEALDNVLPSAQLM 320
W+ A +N LP+ ++
Sbjct: 367 WVQGC-APENTLPTPMVL 383
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 175 bits (444), Expect = 7e-44
Identities = 107/313 (34%), Positives = 165/313 (52%), Gaps = 40/313 (12%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLHMMCATHPNIVQIIEVFA 83
+ +G G + CV K+T +A+KI+ D+ K E+ + + HPNI+ + +V+
Sbjct: 427 EDIGVGSYSVCKRCVHKATDTEYAVKII-DKSKRDPSEEIEILLRYGQHPNIITLKDVYD 485
Query: 84 NSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLN 143
+ + +VME+M GGEL RI + R+F+E++AS V I + + H
Sbjct: 486 DG----------KFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 535
Query: 144 IAHRDLKPENLLFKDNS-LDAPVKLCDFGFAK---IDQGDLMTPQFTPYYVAPQVLEAQR 199
+ HRDLKP N+L++D S +++CDFGFAK G LMTP +T +VAP+VL+ Q
Sbjct: 536 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQ- 594
Query: 200 RHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIM 259
Y+ +CD+WSLG+++Y ML G+ PF + P+++ +I
Sbjct: 595 -----------------GYDAACDIWSLGILLYTMLAGFTPF--ANGPDDTPEEILARIG 635
Query: 260 TGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQL 319
+G + W IS+ AKDVV K+L V P +RLT VL HPW+ + E L P+
Sbjct: 636 SGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLS---PNQLS 692
Query: 320 MMDKAVVAGIQQA 332
D +V G A
Sbjct: 693 RQDVHLVKGAMAA 705
Score = 94.4 bits (233), Expect = 2e-19
Identities = 87/294 (29%), Positives = 133/294 (45%), Gaps = 59/294 (20%)
Query: 28 LGAGISGPVRVCVK---KSTQERFALKILLDRP-KARNEVRLHMMC-----ATHPNIVQI 78
LG G G V + K + +A+K+L K R+ VR M HP IV++
Sbjct: 73 LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKL 132
Query: 79 IEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRH 138
F +L ++++ + GG+LF R+S+ FTE+ ++ALAL H
Sbjct: 133 HYAFQTE----------GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 182
Query: 139 CHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQF--TPYYVAPQV 194
H L I +RDLKPEN+L + + +K+ DFG +K ID D F T Y+AP+V
Sbjct: 183 LHSLGIIYRDLKPENILLDE---EGHIKITDFGLSKEAIDH-DKRAYSFCGTIEYMAPEV 238
Query: 195 LEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDM 254
+ +R H +S D WS GV+++ ML G PF K T+ +
Sbjct: 239 VN-RRGH-----------------TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 280
Query: 255 RRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERL-----TIEGVLDHPW 303
+ K+ F +S A+ ++R L K P RL +E + HP+
Sbjct: 281 KAKLGMPQF---------LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 325
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 175 bits (444), Expect = 7e-44
Identities = 107/313 (34%), Positives = 165/313 (52%), Gaps = 40/313 (12%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLHMMCATHPNIVQIIEVFA 83
+ +G G + CV K+T +A+KI+ D+ K E+ + + HPNI+ + +V+
Sbjct: 419 EDIGVGSYSVCKRCVHKATDTEYAVKII-DKSKRDPSEEIEILLRYGQHPNIITLKDVYD 477
Query: 84 NSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLN 143
+ + +VME+M GGEL RI + R+F+E++AS V I + + H
Sbjct: 478 DG----------KFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQG 527
Query: 144 IAHRDLKPENLLFKDNS-LDAPVKLCDFGFAK---IDQGDLMTPQFTPYYVAPQVLEAQR 199
+ HRDLKP N+L++D S +++CDFGFAK G LMTP +T +VAP+VL+ Q
Sbjct: 528 VVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQ- 586
Query: 200 RHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIM 259
Y+ +CD+WSLG+++Y ML G+ PF + P+++ +I
Sbjct: 587 -----------------GYDAACDIWSLGILLYTMLAGFTPF--ANGPDDTPEEILARIG 627
Query: 260 TGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQL 319
+G + W IS+ AKDVV K+L V P +RLT VL HPW+ + E L P+
Sbjct: 628 SGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLS---PNQLS 684
Query: 320 MMDKAVVAGIQQA 332
D +V G A
Sbjct: 685 RQDVHLVKGAMAA 697
Score = 94.4 bits (233), Expect = 2e-19
Identities = 87/294 (29%), Positives = 133/294 (45%), Gaps = 59/294 (20%)
Query: 28 LGAGISGPVRVCVK---KSTQERFALKILLDRP-KARNEVRLHMMC-----ATHPNIVQI 78
LG G G V + K + +A+K+L K R+ VR M HP IV++
Sbjct: 65 LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKL 124
Query: 79 IEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRH 138
F +L ++++ + GG+LF R+S+ FTE+ ++ALAL H
Sbjct: 125 HYAFQTE----------GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 174
Query: 139 CHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQF--TPYYVAPQV 194
H L I +RDLKPEN+L + + +K+ DFG +K ID D F T Y+AP+V
Sbjct: 175 LHSLGIIYRDLKPENILLDE---EGHIKITDFGLSKEAIDH-DKRAYSFCGTIEYMAPEV 230
Query: 195 LEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDM 254
+ +R H +S D WS GV+++ ML G PF K T+ +
Sbjct: 231 VN-RRGH-----------------TQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALIL 272
Query: 255 RRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERL-----TIEGVLDHPW 303
+ K+ F +S A+ ++R L K P RL +E + HP+
Sbjct: 273 KAKLGMPQF---------LSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 317
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 174 bits (442), Expect = 1e-43
Identities = 107/309 (34%), Positives = 165/309 (53%), Gaps = 38/309 (12%)
Query: 11 IKETSILEEYSINWTQK-LGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLHM 67
++++ ++Y ++ + LG G R C ++ + + FA+KIL R +A + EV
Sbjct: 399 MQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANTQREVAALR 458
Query: 68 MCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQ 127
+C +HPN+V + EV + + +V+E++ GGEL I + RHF+E +ASQ
Sbjct: 459 LCQSHPNVVNLHEVHHDQLH----------TYLVLELLRGGELLEHIRKKRHFSESEASQ 508
Query: 128 VTKQIALALRHCHL-LNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGD----LMT 182
+ + + A+ H + HRDLKPEN+L+ D++ APVK+ DFGFA++ + T
Sbjct: 509 ILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPMQT 568
Query: 183 PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY 242
P FT Y AP++L Q Y++SCDLWSLGVI+Y+ML G PF
Sbjct: 569 PCFTLQYAAPELLAQQ------------------GYDESCDLWSLGVILYMMLSGQVPFQ 610
Query: 243 --SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLD 300
S ++ ++ KI G F E W +SE AK++VR LL V P +RL +EG+
Sbjct: 611 GASGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRG 670
Query: 301 HPWLNSTEA 309
WL A
Sbjct: 671 SSWLQDGSA 679
Score = 92.8 bits (229), Expect = 6e-19
Identities = 84/336 (25%), Positives = 150/336 (44%), Gaps = 59/336 (17%)
Query: 1 MSEESDMDKAIKETSILEEYSINWTQK-----------LGAGISGPVRVCVKKSTQER-- 47
M +E D + E I E +K LG G G V + K +
Sbjct: 1 MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGK 60
Query: 48 -FALKIL-----LDRPKARNEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIV 101
+A+K+L + R K + R T ++++++ V + A+L ++
Sbjct: 61 LYAMKVLRKAALVQRAKTQEHTR------TERSVLELVRQAPFLVTLHYAFQTDAKLHLI 114
Query: 102 MEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSL 161
++ + GGE+F + Q ++F E + +I LAL H H L I +RDLK EN+L
Sbjct: 115 LDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDS--- 171
Query: 162 DAPVKLCDFGFAK--IDQGDLMTPQF--TPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYT 217
+ + L DFG +K + + T F T Y+AP+++ ++ H
Sbjct: 172 EGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGH---------------- 215
Query: 218 YNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMA 277
K+ D WSLG++++ +L G PF + R ++ R+I+ S FP +I +A
Sbjct: 216 -GKAVDWWSLGILLFELLTGASPF-TLEGERNTQAEVSRRILKCSPPFP----PRIGPVA 269
Query: 278 KDVVRKLLKVKPEERL-----TIEGVLDHPWLNSTE 308
+D++++LL P++RL + V +HP+ +
Sbjct: 270 QDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLD 305
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 174 bits (440), Expect = 2e-43
Identities = 105/315 (33%), Positives = 174/315 (55%), Gaps = 47/315 (14%)
Query: 8 DKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKA-------R 60
++ + +++LE+Y I + +G G V+ C+ +ST + FALKI+ D+ K
Sbjct: 381 NRCSESSTLLEKYKIG--KVIGDGNFAVVKECIDRSTGKEFALKII-DKAKCCGKEHLIE 437
Query: 61 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 120
NEV + + HPNI+ ++E E L +VME+++GG+LF I+ +
Sbjct: 438 NEVSI-LRRVKHPNIIMLVE----------EMETATELFLVMELVKGGDLFDAITSSTKY 486
Query: 121 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLL---FKDNSLDAPVKLCDFGFAKIDQ 177
TE+ S + +A ALR+ H L+I HRD+KPENLL + D + +KL DFG A + +
Sbjct: 487 TERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGT--KSLKLGDFGLATVVE 544
Query: 178 GDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCG 237
G L T TP YVAP+++ ++G Y D+W+ GVI Y++LCG
Sbjct: 545 GPLYTVCGTPTYVAPEII--------AETG----------YGLKVDIWAAGVITYILLCG 586
Query: 238 YPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEG 297
+PPF S+++ + +D+ +I+ G EFP W I++ AK+++ ++L+V E R T
Sbjct: 587 FPPFRSENN---LQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQ 643
Query: 298 VLDHPWLNSTEALDN 312
+L HPW++ + +N
Sbjct: 644 ILSHPWVSDDASQEN 658
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 174 bits (440), Expect = 2e-43
Identities = 105/315 (33%), Positives = 174/315 (55%), Gaps = 47/315 (14%)
Query: 8 DKAIKETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKA-------R 60
++ + +++LE+Y I + +G G V+ C+ +ST + FALKI+ D+ K
Sbjct: 382 NRCSESSTLLEKYKIG--KVIGDGNFAVVKECIDRSTGKEFALKII-DKAKCCGKEHLIE 438
Query: 61 NEVRLHMMCATHPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHF 120
NEV + + HPNI+ ++E E L +VME+++GG+LF I+ +
Sbjct: 439 NEVSI-LRRVKHPNIIMLVE----------EMETATELFLVMELVKGGDLFDAITSSTKY 487
Query: 121 TEKQASQVTKQIALALRHCHLLNIAHRDLKPENLL---FKDNSLDAPVKLCDFGFAKIDQ 177
TE+ S + +A ALR+ H L+I HRD+KPENLL + D + +KL DFG A + +
Sbjct: 488 TERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGT--KSLKLGDFGLATVVE 545
Query: 178 GDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCG 237
G L T TP YVAP+++ ++G Y D+W+ GVI Y++LCG
Sbjct: 546 GPLYTVCGTPTYVAPEII--------AETG----------YGLKVDIWAAGVITYILLCG 587
Query: 238 YPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEG 297
+PPF S+++ + +D+ +I+ G EFP W I++ AK+++ ++L+V E R T
Sbjct: 588 FPPFRSENN---LQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVNVEARCTAGQ 644
Query: 298 VLDHPWLNSTEALDN 312
+L HPW++ + +N
Sbjct: 645 ILSHPWVSDDASQEN 659
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 172 bits (437), Expect = 5e-43
Identities = 102/288 (35%), Positives = 161/288 (55%), Gaps = 38/288 (13%)
Query: 27 KLGAGISGPVRVCVKKSTQERFALKIL---LDRPKARNEVRLHMMCATHPNIVQIIEVFA 83
+LG G + V C +K TQ+ +ALK+L +D+ R E+ + ++ +HPNI+++ E+F
Sbjct: 51 ELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGV-LLRLSHPNIIKLKEIF- 108
Query: 84 NSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLN 143
+ P E S +V+E++ GGELF RI + +++E+ A+ KQI A+ + H
Sbjct: 109 ---ETPTEIS------LVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENG 159
Query: 144 IAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLM--TPQFTPYYVAPQVLEAQRRH 201
I HRDLKPENLL+ + DAP+K+ DFG +KI + ++ T TP Y AP++L
Sbjct: 160 IVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRG---- 215
Query: 202 QKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTG 261
Y D+WS+G+I Y++LCG+ PFY + + M R+I+
Sbjct: 216 --------------CAYGPEVDMWSVGIITYILLCGFEPFYDERGDQF----MFRRILNC 257
Query: 262 SFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEA 309
+ F W ++S AKD+VRKL+ + P++RLT L HPW+ A
Sbjct: 258 EYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAA 305
>gi|207113186 MAP kinase-interacting serine/threonine kinase 1
isoform 3 [Homo sapiens]
Length = 424
Score = 171 bits (432), Expect = 2e-42
Identities = 107/339 (31%), Positives = 167/339 (49%), Gaps = 49/339 (14%)
Query: 25 TQKLGAGISGPVRVCVKKSTQERFALKILL-----DRPKARNEVRLHMMCATHPNIVQII 79
++ LG G V+ V + +A+KI+ R + EV C + NI+++I
Sbjct: 52 SELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELI 111
Query: 80 EVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHC 139
E F + +F +V E ++GG + I + +HF E++AS+V + +A AL
Sbjct: 112 EFFEDDTRF----------YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFL 161
Query: 140 HLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK----------IDQGDLMTPQFTPYY 189
H IAHRDLKPEN+L + +PVK+CDF I +L TP + Y
Sbjct: 162 HTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEY 221
Query: 190 VAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSK----- 244
+AP+V+E + T + Y+K CDLWSLGV++Y+ML GYPPF
Sbjct: 222 MAPEVVE------------VFTDQATF-YDKRCDLWSLGVVLYIMLSGYPPFVGHCGADC 268
Query: 245 -----HHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVL 299
R + I G +EFP+++W+ IS AKD++ KLL ++RL+ VL
Sbjct: 269 GWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVL 328
Query: 300 DHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLA 338
HPW+ +A + LP+ Q++ + + AE +A
Sbjct: 329 QHPWVQG-QAPEKGLPTPQVLQRNSSTMDLTLFAAEAIA 366
>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
isoform 5 [Homo sapiens]
Length = 492
Score = 170 bits (431), Expect = 2e-42
Identities = 118/392 (30%), Positives = 186/392 (47%), Gaps = 60/392 (15%)
Query: 14 TSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKIL-------LDRPKARNEVRLH 66
T +EY + ++LG G VR C+K T + +A KI+ D K E R+
Sbjct: 8 TRFTDEYQL--FEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 67 MMCATHPNIVQIIEVFANSVQFPHES-SPRARLLIVMEMMEGGELFHRISQHRHFTEKQA 125
+ HPNIV++ H+S S +V +++ GGELF I +++E A
Sbjct: 66 RLLK-HPNIVRL-----------HDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADA 113
Query: 126 SQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMT--- 182
S +QI ++ HCHL I HRDLKPENLL S A VKL DFG A QGD
Sbjct: 114 SHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFG 173
Query: 183 PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY 242
TP Y++P+VL Y K D+W+ GVI+Y++L GYPPF+
Sbjct: 174 FAGTPGYLSPEVLRKD------------------PYGKPVDMWACGVILYILLVGYPPFW 215
Query: 243 SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ R + ++I G+++FP EW ++ AKD++ K+L + P +R+T L HP
Sbjct: 216 DEDQHR-----LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
Query: 303 WLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRK 362
W+ + A +M + V +++ +A + I ++ + + + +
Sbjct: 271 WICQRSTV------ASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLL--- 321
Query: 363 RKLLGTKPKDSVYIHD---HENGAEDSNVALE 391
+K G K + IH+ ++ E SN +E
Sbjct: 322 KKPDGVKEPQTTVIHNPDGNKESTESSNTTIE 353
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 170 bits (430), Expect = 3e-42
Identities = 98/285 (34%), Positives = 156/285 (54%), Gaps = 37/285 (12%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKA--RNEVRLHMMCATHPNIVQIIEVFA 83
+ +G G + C+ K+T FA+KI+ D+ K E+ + + HPNI+ + +V+
Sbjct: 426 EDIGVGSYSVCKRCIHKATNMEFAVKII-DKSKRDPTEEIEILLRYGQHPNIITLKDVYD 484
Query: 84 NSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLLN 143
+ + +V E+M+GGEL +I + + F+E++AS V I + + H
Sbjct: 485 DGKY----------VYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQG 534
Query: 144 IAHRDLKPENLLFKDNSLD-APVKLCDFGFAK---IDQGDLMTPQFTPYYVAPQVLEAQR 199
+ HRDLKP N+L+ D S + +++CDFGFAK + G LMTP +T +VAP+VL+ Q
Sbjct: 535 VVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQ- 593
Query: 200 RHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIM 259
Y+ +CD+WSLGV++Y ML GY PF + P+++ +I
Sbjct: 594 -----------------GYDAACDIWSLGVLLYTMLTGYTPF--ANGPDDTPEEILARIG 634
Query: 260 TGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWL 304
+G F W+ +S+ AKD+V K+L V P +RLT VL HPW+
Sbjct: 635 SGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
Score = 99.4 bits (246), Expect = 6e-21
Identities = 86/279 (30%), Positives = 130/279 (46%), Gaps = 54/279 (19%)
Query: 28 LGAGISGPVRVCVKKS---TQERFALKILLDRP-KARNEVRLHM-----MCATHPNIVQI 78
LG G G V + K S ++ +A+K+L K R+ VR M + HP IV++
Sbjct: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKL 133
Query: 79 IEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRH 138
F +L ++++ + GG+LF R+S+ FTE+ ++ALAL H
Sbjct: 134 HYAFQTE----------GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDH 183
Query: 139 CHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--IDQGDLMTPQF--TPYYVAPQV 194
H L I +RDLKPEN+L + + +KL DFG +K ID + F T Y+AP+V
Sbjct: 184 LHSLGIIYRDLKPENILLDE---EGHIKLTDFGLSKESIDH-EKKAYSFCGTVEYMAPEV 239
Query: 195 LEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDM 254
+ +R H +S D WS GV+++ ML G PF K T+ +
Sbjct: 240 VN-RRGH-----------------TQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL 281
Query: 255 RRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERL 293
+ K+ F PE A+ ++R L K P RL
Sbjct: 282 KAKLGMPQFLSPE---------AQSLLRMLFKRNPANRL 311
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 170 bits (430), Expect = 3e-42
Identities = 103/291 (35%), Positives = 154/291 (52%), Gaps = 40/291 (13%)
Query: 28 LGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCAT-----HPNIVQIIEVF 82
LG G V + K TQ+ A+K + E + A HPNIV + +++
Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIY 85
Query: 83 ANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCHLL 142
+ L ++M+++ GGELF RI + +TE+ AS++ Q+ A+++ H L
Sbjct: 86 ESG----------GHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDL 135
Query: 143 NIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKI-DQGD-LMTPQFTPYYVAPQVLEAQRR 200
I HRDLKPENLL+ D+ + + DFG +K+ D G L T TP YVAP+VL AQ+
Sbjct: 136 GIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL-AQK- 193
Query: 201 HQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMT 260
Y+K+ D WS+GVI Y++LCGYPPFY ++ ++ + +I+
Sbjct: 194 ----------------PYSKAVDCWSIGVIAYILLCGYPPFYDENDAK-----LFEQILK 232
Query: 261 GSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALD 311
+EF W IS+ AKD +R L++ PE+R T E L HPW+ ALD
Sbjct: 233 AEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALD 283
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 169 bits (429), Expect = 4e-42
Identities = 103/292 (35%), Positives = 155/292 (53%), Gaps = 39/292 (13%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA-----THPNIVQIIE 80
++LG+G V + ++ + ALK + + E + A +HPNIV + +
Sbjct: 36 ERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALED 95
Query: 81 VFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCH 140
V HES + L + ME++ GGELF RI + +TEK AS + Q+ A+ + H
Sbjct: 96 V--------HESP--SHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLH 145
Query: 141 LLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLM-TPQFTPYYVAPQVLEAQR 199
L I HRDLKPENLL+ D+ + + DFG +KI G+++ T TP YVAP++LE +
Sbjct: 146 SLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQK- 204
Query: 200 RHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIM 259
Y K+ D+W+LGVI Y++LCGYPPFY + ++ +I+
Sbjct: 205 -----------------PYGKAVDVWALGVISYILLCGYPPFYDES-----DPELFSQIL 242
Query: 260 TGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALD 311
S+EF W ISE AKD +R LL+ P++R T + L H W++ A D
Sbjct: 243 RASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFD 294
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 169 bits (429), Expect = 4e-42
Identities = 103/292 (35%), Positives = 155/292 (53%), Gaps = 39/292 (13%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCA-----THPNIVQIIE 80
++LG+G V + ++ + ALK + + E + A +HPNIV + +
Sbjct: 102 ERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALED 161
Query: 81 VFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCH 140
V HES + L + ME++ GGELF RI + +TEK AS + Q+ A+ + H
Sbjct: 162 V--------HESP--SHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLH 211
Query: 141 LLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLM-TPQFTPYYVAPQVLEAQR 199
L I HRDLKPENLL+ D+ + + DFG +KI G+++ T TP YVAP++LE +
Sbjct: 212 SLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQK- 270
Query: 200 RHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIM 259
Y K+ D+W+LGVI Y++LCGYPPFY + ++ +I+
Sbjct: 271 -----------------PYGKAVDVWALGVISYILLCGYPPFYDES-----DPELFSQIL 308
Query: 260 TGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALD 311
S+EF W ISE AKD +R LL+ P++R T + L H W++ A D
Sbjct: 309 RASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFD 360
>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
isoform 4 [Homo sapiens]
Length = 489
Score = 168 bits (426), Expect = 9e-42
Identities = 104/302 (34%), Positives = 152/302 (50%), Gaps = 48/302 (15%)
Query: 14 TSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKIL-------LDRPKARNEVRLH 66
T +EY + ++LG G VR C+K T + +A KI+ D K E R+
Sbjct: 8 TRFTDEYQL--FEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 67 MMCATHPNIVQIIEVFANSVQFPHES-SPRARLLIVMEMMEGGELFHRISQHRHFTEKQA 125
+ HPNIV++ H+S S +V +++ GGELF I +++E A
Sbjct: 66 RLLK-HPNIVRL-----------HDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADA 113
Query: 126 SQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMT--- 182
S +QI ++ HCHL I HRDLKPENLL S A VKL DFG A QGD
Sbjct: 114 SHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFG 173
Query: 183 PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY 242
TP Y++P+VL Y K D+W+ GVI+Y++L GYPPF+
Sbjct: 174 FAGTPGYLSPEVLRKD------------------PYGKPVDMWACGVILYILLVGYPPFW 215
Query: 243 SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ R + ++I G+++FP EW ++ AKD++ K+L + P +R+T L HP
Sbjct: 216 DEDQHR-----LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
Query: 303 WL 304
W+
Sbjct: 271 WI 272
>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 168 bits (426), Expect = 9e-42
Identities = 104/302 (34%), Positives = 152/302 (50%), Gaps = 48/302 (15%)
Query: 14 TSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKIL-------LDRPKARNEVRLH 66
T +EY + ++LG G VR C+K T + +A KI+ D K E R+
Sbjct: 8 TRFTDEYQL--FEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 67 MMCATHPNIVQIIEVFANSVQFPHES-SPRARLLIVMEMMEGGELFHRISQHRHFTEKQA 125
+ HPNIV++ H+S S +V +++ GGELF I +++E A
Sbjct: 66 RLLK-HPNIVRL-----------HDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADA 113
Query: 126 SQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMT--- 182
S +QI ++ HCHL I HRDLKPENLL S A VKL DFG A QGD
Sbjct: 114 SHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFG 173
Query: 183 PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY 242
TP Y++P+VL Y K D+W+ GVI+Y++L GYPPF+
Sbjct: 174 FAGTPGYLSPEVLRKD------------------PYGKPVDMWACGVILYILLVGYPPFW 215
Query: 243 SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ R + ++I G+++FP EW ++ AKD++ K+L + P +R+T L HP
Sbjct: 216 DEDQHR-----LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
Query: 303 WL 304
W+
Sbjct: 271 WI 272
>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
isoform 1 [Homo sapiens]
Length = 478
Score = 168 bits (426), Expect = 9e-42
Identities = 104/302 (34%), Positives = 152/302 (50%), Gaps = 48/302 (15%)
Query: 14 TSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKIL-------LDRPKARNEVRLH 66
T +EY + ++LG G VR C+K T + +A KI+ D K E R+
Sbjct: 8 TRFTDEYQL--FEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 67 MMCATHPNIVQIIEVFANSVQFPHES-SPRARLLIVMEMMEGGELFHRISQHRHFTEKQA 125
+ HPNIV++ H+S S +V +++ GGELF I +++E A
Sbjct: 66 RLLK-HPNIVRL-----------HDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADA 113
Query: 126 SQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMT--- 182
S +QI ++ HCHL I HRDLKPENLL S A VKL DFG A QGD
Sbjct: 114 SHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFG 173
Query: 183 PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY 242
TP Y++P+VL Y K D+W+ GVI+Y++L GYPPF+
Sbjct: 174 FAGTPGYLSPEVLRKD------------------PYGKPVDMWACGVILYILLVGYPPFW 215
Query: 243 SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ R + ++I G+++FP EW ++ AKD++ K+L + P +R+T L HP
Sbjct: 216 DEDQHR-----LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
Query: 303 WL 304
W+
Sbjct: 271 WI 272
>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
isoform 2 [Homo sapiens]
Length = 478
Score = 168 bits (426), Expect = 9e-42
Identities = 104/302 (34%), Positives = 152/302 (50%), Gaps = 48/302 (15%)
Query: 14 TSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKIL-------LDRPKARNEVRLH 66
T +EY + ++LG G VR C+K T + +A KI+ D K E R+
Sbjct: 8 TRFTDEYQL--FEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 67 MMCATHPNIVQIIEVFANSVQFPHES-SPRARLLIVMEMMEGGELFHRISQHRHFTEKQA 125
+ HPNIV++ H+S S +V +++ GGELF I +++E A
Sbjct: 66 RLLK-HPNIVRL-----------HDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADA 113
Query: 126 SQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMT--- 182
S +QI ++ HCHL I HRDLKPENLL S A VKL DFG A QGD
Sbjct: 114 SHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFG 173
Query: 183 PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY 242
TP Y++P+VL Y K D+W+ GVI+Y++L GYPPF+
Sbjct: 174 FAGTPGYLSPEVLRKD------------------PYGKPVDMWACGVILYILLVGYPPFW 215
Query: 243 SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ R + ++I G+++FP EW ++ AKD++ K+L + P +R+T L HP
Sbjct: 216 DEDQHR-----LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
Query: 303 WL 304
W+
Sbjct: 271 WI 272
>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
isoform 3 [Homo sapiens]
Length = 499
Score = 168 bits (426), Expect = 9e-42
Identities = 104/302 (34%), Positives = 152/302 (50%), Gaps = 48/302 (15%)
Query: 14 TSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKIL-------LDRPKARNEVRLH 66
T +EY + ++LG G VR C+K T + +A KI+ D K E R+
Sbjct: 8 TRFTDEYQL--FEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65
Query: 67 MMCATHPNIVQIIEVFANSVQFPHES-SPRARLLIVMEMMEGGELFHRISQHRHFTEKQA 125
+ HPNIV++ H+S S +V +++ GGELF I +++E A
Sbjct: 66 RLLK-HPNIVRL-----------HDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADA 113
Query: 126 SQVTKQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKIDQGDLMT--- 182
S +QI ++ HCHL I HRDLKPENLL S A VKL DFG A QGD
Sbjct: 114 SHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFG 173
Query: 183 PQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFY 242
TP Y++P+VL Y K D+W+ GVI+Y++L GYPPF+
Sbjct: 174 FAGTPGYLSPEVLRKD------------------PYGKPVDMWACGVILYILLVGYPPFW 215
Query: 243 SKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHP 302
+ R + ++I G+++FP EW ++ AKD++ K+L + P +R+T L HP
Sbjct: 216 DEDQHR-----LYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHP 270
Query: 303 WL 304
W+
Sbjct: 271 WI 272
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 167 bits (422), Expect = 2e-41
Identities = 102/293 (34%), Positives = 158/293 (53%), Gaps = 40/293 (13%)
Query: 26 QKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCAT-----HPNIVQIIE 80
+ LG G V + +K+T + FA+K + + E + A H NIV + +
Sbjct: 27 ETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALED 86
Query: 81 VFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALRHCH 140
++ SP L +VM+++ GGELF RI + +TEK AS + +Q+ A+ + H
Sbjct: 87 IY---------ESPN-HLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLH 136
Query: 141 LLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAKID-QGDLM-TPQFTPYYVAPQVLEAQ 198
+ I HRDLKPENLL+ ++ + + DFG +K++ +GD+M T TP YVAP+VL AQ
Sbjct: 137 RMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVL-AQ 195
Query: 199 RRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKI 258
+ Y+K+ D WS+GVI Y++LCGYPPFY ++ S+ + +I
Sbjct: 196 K-----------------PYSKAVDCWSIGVIAYILLCGYPPFYDENDSK-----LFEQI 233
Query: 259 MTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALD 311
+ +EF W IS+ AKD +R L++ P +R T E HPW+ AL+
Sbjct: 234 LKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALN 286
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,195,905
Number of Sequences: 37866
Number of extensions: 817090
Number of successful extensions: 4045
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 467
Number of HSP's successfully gapped in prelim test: 279
Number of HSP's that attempted gapping in prelim test: 2162
Number of HSP's gapped (non-prelim): 902
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.