Search of human proteins with 21040314

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
         (2303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]         4462   0.0  
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]         4288   0.0  
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]       156   2e-37
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]      125   5e-28
gi|91982772 mucin 17 [Homo sapiens]                                   122   5e-27
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]         108   6e-23
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]          108   6e-23
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                 107   1e-22
gi|16554449 zonadhesin isoform 3 [Homo sapiens]                       107   1e-22
gi|27881494 zonadhesin isoform 6 [Homo sapiens]                       107   1e-22
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]    105   4e-22
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s...   104   9e-22
gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo s...   102   3e-21
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...   101   7e-21
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...   101   7e-21
gi|46309849 hypothetical protein LOC57035 [Homo sapiens]              101   7e-21
gi|153251865 hypothetical protein LOC84226 [Homo sapiens]             100   1e-20
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]    100   2e-20
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]        100   2e-20
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]   100   2e-20
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...    99   4e-20
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...    99   4e-20
gi|221139764 PHD and ring finger domains 1 [Homo sapiens]              98   8e-20
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    97   2e-19
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    96   4e-19
gi|42741682 zinc finger protein 265 isoform 2 [Homo sapiens]           96   4e-19
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   92   8e-18
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   92   8e-18
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   92   8e-18
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    92   8e-18

>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
          Length = 2303

 Score = 4462 bits (11574), Expect = 0.0
 Identities = 2303/2303 (100%), Positives = 2303/2303 (100%)

Query: 1    MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEE 60
            MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEE
Sbjct: 1    MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEE 60

Query: 61   IVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKK 120
            IVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKK
Sbjct: 61   IVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKK 120

Query: 121  KKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETN 180
            KKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETN
Sbjct: 121  KKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETN 180

Query: 181  ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTK 240
            ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTK
Sbjct: 181  ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTK 240

Query: 241  ILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL 300
            ILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL
Sbjct: 241  ILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL 300

Query: 301  EPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQE 360
            EPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQE
Sbjct: 301  EPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQE 360

Query: 361  LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL 420
            LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL
Sbjct: 361  LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL 420

Query: 421  STPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELP 480
            STPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELP
Sbjct: 421  STPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELP 480

Query: 481  GLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQP 540
            GLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQP
Sbjct: 481  GLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQP 540

Query: 541  EATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPL 600
            EATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPL
Sbjct: 541  EATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPL 600

Query: 601  MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT 660
            MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT
Sbjct: 601  MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT 660

Query: 661  TSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNT 720
            TSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNT
Sbjct: 661  TSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNT 720

Query: 721  METHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSS 780
            METHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSS
Sbjct: 721  METHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSS 780

Query: 781  MDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATST 840
            MDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATST
Sbjct: 781  MDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATST 840

Query: 841  MDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASST 900
            MDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASST
Sbjct: 841  MDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASST 900

Query: 901  QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP 960
            QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP
Sbjct: 901  QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP 960

Query: 961  DPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSY 1020
            DPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSY
Sbjct: 961  DPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSY 1020

Query: 1021 ERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAD 1080
            ERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAD
Sbjct: 1021 ERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAD 1080

Query: 1081 RSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTY 1140
            RSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTY
Sbjct: 1081 RSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTY 1140

Query: 1141 TEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP 1200
            TEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP
Sbjct: 1141 TEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP 1200

Query: 1201 SSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT 1260
            SSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT
Sbjct: 1201 SSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT 1260

Query: 1261 LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH 1320
            LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH
Sbjct: 1261 LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH 1320

Query: 1321 VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESST 1380
            VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESST
Sbjct: 1321 VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESST 1380

Query: 1381 VTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440
            VTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV
Sbjct: 1381 VTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440

Query: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500
            QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI
Sbjct: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500

Query: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560
            GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE
Sbjct: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560

Query: 1561 IGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTL 1620
            IGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTL
Sbjct: 1561 IGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTL 1620

Query: 1621 SLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTE 1680
            SLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTE
Sbjct: 1621 SLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTE 1680

Query: 1681 EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK 1740
            EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK
Sbjct: 1681 EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK 1740

Query: 1741 DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH 1800
            DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH
Sbjct: 1741 DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH 1800

Query: 1801 EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ 1860
            EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ
Sbjct: 1801 EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ 1860

Query: 1861 TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA 1920
            TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA
Sbjct: 1861 TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA 1920

Query: 1921 RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT 1980
            RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT
Sbjct: 1921 RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT 1980

Query: 1981 PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040
            PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS
Sbjct: 1981 PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040

Query: 2041 SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGA 2100
            SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGA
Sbjct: 2041 SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGA 2100

Query: 2101 TIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAA 2160
            TIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAA
Sbjct: 2101 TIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAA 2160

Query: 2161 KPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSEG 2220
            KPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSEG
Sbjct: 2161 KPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSEG 2220

Query: 2221 RVKRQGRVRRQMKQPAASHLTVTRCNSLCGTKPQSEKHRIAENSVITSLPNIGPSLHLWE 2280
            RVKRQGRVRRQMKQPAASHLTVTRCNSLCGTKPQSEKHRIAENSVITSLPNIGPSLHLWE
Sbjct: 2221 RVKRQGRVRRQMKQPAASHLTVTRCNSLCGTKPQSEKHRIAENSVITSLPNIGPSLHLWE 2280

Query: 2281 GSPRYNYLASRFASRLYSSRFWW 2303
            GSPRYNYLASRFASRLYSSRFWW
Sbjct: 2281 GSPRYNYLASRFASRLYSSRFWW 2303


>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
          Length = 2426

 Score = 4288 bits (11122), Expect = 0.0
 Identities = 2219/2219 (100%), Positives = 2219/2219 (100%)

Query: 1    MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEE 60
            MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEE
Sbjct: 1    MATNIEQIFRSFVVSKFREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEE 60

Query: 61   IVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKK 120
            IVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKK
Sbjct: 61   IVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKK 120

Query: 121  KKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETN 180
            KKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETN
Sbjct: 121  KKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETN 180

Query: 181  ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTK 240
            ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTK
Sbjct: 181  ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTK 240

Query: 241  ILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL 300
            ILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL
Sbjct: 241  ILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL 300

Query: 301  EPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQE 360
            EPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQE
Sbjct: 301  EPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQE 360

Query: 361  LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL 420
            LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL
Sbjct: 361  LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL 420

Query: 421  STPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELP 480
            STPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELP
Sbjct: 421  STPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELP 480

Query: 481  GLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQP 540
            GLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQP
Sbjct: 481  GLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQP 540

Query: 541  EATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPL 600
            EATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPL
Sbjct: 541  EATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPL 600

Query: 601  MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT 660
            MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT
Sbjct: 601  MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT 660

Query: 661  TSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNT 720
            TSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNT
Sbjct: 661  TSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHILASNT 720

Query: 721  METHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSS 780
            METHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSS
Sbjct: 721  METHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSS 780

Query: 781  MDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATST 840
            MDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATST
Sbjct: 781  MDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATST 840

Query: 841  MDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASST 900
            MDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASST
Sbjct: 841  MDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASST 900

Query: 901  QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP 960
            QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP
Sbjct: 901  QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP 960

Query: 961  DPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSY 1020
            DPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSY
Sbjct: 961  DPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSY 1020

Query: 1021 ERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAD 1080
            ERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAD
Sbjct: 1021 ERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAD 1080

Query: 1081 RSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTY 1140
            RSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTY
Sbjct: 1081 RSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTY 1140

Query: 1141 TEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP 1200
            TEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP
Sbjct: 1141 TEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP 1200

Query: 1201 SSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT 1260
            SSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT
Sbjct: 1201 SSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT 1260

Query: 1261 LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH 1320
            LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH
Sbjct: 1261 LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH 1320

Query: 1321 VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESST 1380
            VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESST
Sbjct: 1321 VASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESST 1380

Query: 1381 VTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440
            VTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV
Sbjct: 1381 VTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440

Query: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500
            QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI
Sbjct: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500

Query: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560
            GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE
Sbjct: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560

Query: 1561 IGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTL 1620
            IGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTL
Sbjct: 1561 IGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTL 1620

Query: 1621 SLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTE 1680
            SLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTE
Sbjct: 1621 SLVNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTE 1680

Query: 1681 EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK 1740
            EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK
Sbjct: 1681 EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK 1740

Query: 1741 DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH 1800
            DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH
Sbjct: 1741 DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH 1800

Query: 1801 EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ 1860
            EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ
Sbjct: 1801 EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ 1860

Query: 1861 TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA 1920
            TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA
Sbjct: 1861 TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA 1920

Query: 1921 RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT 1980
            RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT
Sbjct: 1921 RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRT 1980

Query: 1981 PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040
            PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS
Sbjct: 1981 PSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040

Query: 2041 SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGA 2100
            SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGA
Sbjct: 2041 SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGA 2100

Query: 2101 TIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAA 2160
            TIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAA
Sbjct: 2101 TIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAA 2160

Query: 2161 KPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSE 2219
            KPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSE
Sbjct: 2161 KPTPPKSQVTLTKEFPVSSGSQHRKKEADSVYGEWVPVEKNGEENKDDDNVFSSNLPSE 2219


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score =  156 bits (395), Expect = 2e-37
 Identities = 178/537 (33%), Positives = 240/537 (44%), Gaps = 88/537 (16%)

Query: 1589 AGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTEHDMVISTSPS 1648
            +G       PF+ EP  T T +     TA T    + Y+       +D +     +T PS
Sbjct: 300  SGRRGEGDAPFS-EPGTTSTQRPSSPETA-TKQPSSPYE------DKDKDKKEKSATRPS 351

Query: 1649 GGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSPKESSGGEKEV 1708
               E    GP P     L       L  +    P P+  +  +   +  P E+S      
Sbjct: 352  PSPERSSTGPEPPAPTPL-------LAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRS 404

Query: 1709 PPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAA 1768
            PP   E LP S  S +           P  P+  +      +  E P  A   G  R   
Sbjct: 405  PPKSPEKLPQSSSSES----------SPPSPQPTKVSRHASSSPESPKPAPAPGSHRE-- 452

Query: 1769 SPVVSSMPERASESSSEEKDD----YEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRS 1824
               +SS P   + S    K D    +    ++  +   +   + R +     KR  S RS
Sbjct: 453  ---ISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHS-RS 508

Query: 1825 RS---KRSKSSEHKSRKRTSESRSRAR--KRSSKSKSHRSQTRSRSRSRRRRRS------ 1873
            RS   +RS+S++   R R+ + R R+R  +R   S+S  +Q R RSRS RR RS      
Sbjct: 509  RSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPA 568

Query: 1874 --SRSRSKSRGRRSVSKEKRKRSP-KHRSKSRERKRKRSSSRDNRKTVRARSRTPSRR-S 1929
               RSRS++  RR  S   R R+P + RS+SR   R+RS SR   +  R+RSRTP+RR S
Sbjct: 569  TRGRSRSRTPARRGRS---RSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRS 625

Query: 1930 RSHTPSRRR-RSRSVGRR-------------RSFSISPSRRSRTPSRRSRTPSRRSRTPS 1975
            R+ +P RRR RSRS  RR             RS S +P+RR R+   RSRTP+RRS    
Sbjct: 626  RTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRS---RSRTPARRS--GR 680

Query: 1976 RRSRTPSRRSRTPSRRSRTPSR-RRRSRSVVRR-RSFSISPVRLRR----------SRTP 2023
             RSRTP+RR R+   RSRTP R R RSRS+VRR RS S +P R  R          SRT 
Sbjct: 681  SRSRTPARRGRS---RSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTS 737

Query: 2024 LRRRFSRSPIRRKRSR-SSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPP 2079
             RR  S S    K+SR SS R RS        K++L      + ++ C K     PP
Sbjct: 738  QRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPP 794



 Score =  140 bits (354), Expect = 1e-32
 Identities = 162/469 (34%), Positives = 212/469 (45%), Gaps = 85/469 (18%)

Query: 1697 SPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPL 1756
            SP+ SS  E     PPK      G  ++ E   ++        +   R  S R+  E   
Sbjct: 1648 SPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKS--------RTPPRRRSSRSSPELTR 1699

Query: 1757 LASDVGRDRSAAS---------------PVVSSMPERASESSSEEKDDYEIFVKVKDTHE 1801
             A    R RSA+S               P VSS PE A +S S  +       + K T  
Sbjct: 1700 KARLSRRSRSASSSPETRSRTPPRHRRSPSVSS-PEPAEKSRSSRRRRSASSPRTKTTSR 1758

Query: 1802 KSKK--------NKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSK 1853
            + +          ++R +  +EK R +  R RS  S+S+  + ++  S SR   R+R   
Sbjct: 1759 RGRSPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGS 1818

Query: 1854 SKSHRSQTR---SRSRSRRRRRSSR----SRSKSRGRRSVSKEKRKRS---PKHRSKSRE 1903
                RS  R   SR+ SRRRR  SR    SR +SR R S +  KR RS   P    +SR 
Sbjct: 1819 GYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRS 1878

Query: 1904 R----KRKRSSSRDN---RKTVRARSRTPSRRSRSH-TPSRRRRSRS----VGRRRSFSI 1951
            R     R+RS SR +   R+  R+R+    RRSRS  +P  RRRSRS    V RRRS S 
Sbjct: 1879 RTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSR 1938

Query: 1952 SPSRR----SRTP-----SRRSRTP---SRRSR---TPSRRSRTPSRRSRTPSRRSR--- 1993
            +P+ R    SRTP       RSRTP    RRSR   +P  R R+ SR S    RRSR   
Sbjct: 1939 TPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRT 1998

Query: 1994 TPSRRRRSRS----VVRRRSFSISPVRLR---RSRTPL---RRRFSRSPI---RRKRSRS 2040
            +P  RRRSRS    V RRRS S +P  +R   RSRTPL   +R  SRSP+   RR RSR+
Sbjct: 1999 SPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRT 2058

Query: 2041 SERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTI 2089
                R  + LT    A     A  +++     A  P   N   +  P +
Sbjct: 2059 PRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPV 2107



 Score =  140 bits (353), Expect = 1e-32
 Identities = 123/328 (37%), Positives = 169/328 (51%), Gaps = 51/328 (15%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            R RSA     S  P+R   S S ++  +           +S+  + R +    ++  S  
Sbjct: 515  RSRSAQRWGRSRSPQRRGRSRSPQRPGWS----------RSRNTQRRGRSRSARRGRSHS 564

Query: 1823 RSRSKRSKS-SEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRS--RSK 1879
            RS + R +S S   +R+  S SR+ AR+RS      R ++RSR+ +RR R  SR+  R +
Sbjct: 565  RSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRR 624

Query: 1880 SRGRRSVSKEKRKRSPKHRS-KSRER---KRKRSSSRDNRKTVRARSRTPSRRS---RSH 1932
            SR R  V +  R RSP  RS +SR R   +R RS SR   +  R+RSRTP+RRS   RS 
Sbjct: 625  SRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSR 684

Query: 1933 TPSRRRRSRSVGRRRSFSISPS------RRSRTPSRRSRTPS-----RRSRTPSRRSRTP 1981
            TP+RR RSRS   RR  S S S        SRTP RR R+ S      +SRT  RRSR+ 
Sbjct: 685  TPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSN 744

Query: 1982 S----RRSRTPSRRSR---TPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRR-------- 2026
            S    ++SR  SRRSR   +P  + +SR  +RR     SP   ++S+TP RR        
Sbjct: 745  SSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQP 804

Query: 2027 -RFSRSPIRRKRSRSS----ERGRSPKR 2049
               SR+P RR RS SS    ++ ++P R
Sbjct: 805  KAKSRTPPRRSRSSSSPPPKQKSKTPSR 832



 Score =  137 bits (344), Expect = 2e-31
 Identities = 246/1085 (22%), Positives = 385/1085 (35%), Gaps = 183/1085 (16%)

Query: 1023 SMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRS 1082
            S+ SP A    ++   RS       S   P  +    S +  S  S       +P     
Sbjct: 854  SITSPQANEQSVTPQRRSCFE----SSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSP 909

Query: 1083 MMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTE 1142
              S      + +  S   RS   S S +   + S  T  RS       +        Y+ 
Sbjct: 910  SRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSH 969

Query: 1143 AYMVPPLPPEEPPTMPPLPPEEPPMTP-PLPPEEPPEGPALPTEQSALTAENTWPTEVPS 1201
            +    P    +P T PP       ++P P    + P GP+L   +S    E +  + V S
Sbjct: 970  SGSSSPDTKVKPET-PPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQS 1028

Query: 1202 SPSEES----VSQPEPP------VSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP 1251
             P   S    V    PP      VS  ++   S    D+    S P V  S +       
Sbjct: 1029 CPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHS------- 1081

Query: 1252 PPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAET 1311
                         ES  +  + +  P+             S+  T LAS  P+  +  E 
Sbjct: 1082 -------------ESPSLQSKSQTSPK-------GGRSRSSSPVTELASRSPIRQDRGEF 1121

Query: 1312 FDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESS 1371
              S                      P+L   +    +    +SS+   ++S+++  L  S
Sbjct: 1122 SAS----------------------PMLKSGMSPEQSRFQSDSSSYPTVDSNSL--LGQS 1157

Query: 1372 TVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSM 1431
             +   ES     L P       PP   + D  + P PV            P  S++    
Sbjct: 1158 RLETAESKEKMALPPQEDATASPP--RQKDKFS-PFPVQD---------RPESSLVFKDT 1205

Query: 1432 IVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSI-----MSSHVMKG 1486
            + + P    +E +   S P     EQ   +PT    E    ++E S      + SH+   
Sbjct: 1206 LRTPP----RERSGAGSSPET--KEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSE 1259

Query: 1487 IN-LSSGDQNLAPEI------------GMQEIALHSGEEPHAEEHLKGDFYESEHGINID 1533
            +  +S+ +   +PE+               + +L + E P       G  +  EH    +
Sbjct: 1260 LKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSN 1319

Query: 1534 LNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQR------TVLDTYPGV--- 1584
              +  +     +E       GT       E     +SE K+         L+T P +   
Sbjct: 1320 SPLRENSFGSPLEFRNSGPLGT-------EMNTGFSSEVKEDLNGPFLNQLETDPSLDMK 1372

Query: 1585 --SEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTEHDMV 1642
              S   +G + S   P A+E     +++ I       +      +   S ++ + +  + 
Sbjct: 1373 EQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGL- 1431

Query: 1643 ISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSPKESS 1702
                P   S     G  P        PS ++L          +K+  +T +   S  +SS
Sbjct: 1432 ----PRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPG----MKDIPRTPSRGRSECDSS 1483

Query: 1703 GGEKEVP--PPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASD 1760
               K +P  P P+   P S            +L    L    ER  S           S 
Sbjct: 1484 PEPKALPQTPRPRSRSPSS-----------PELNNKCLTPQRERSGS----------ESS 1522

Query: 1761 VGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDS 1820
            V +   A +P    + +R+   SS+E D       VK +    +++++    + + K  +
Sbjct: 1523 VDQKTVARTP----LGQRSRSGSSQELD-------VKPSASPQERSESDSSPDSKAKTRT 1571

Query: 1821 SLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRS-------------RS 1867
             LR RS+   S E  S+ R S  RSR+          R+  R++S             R+
Sbjct: 1572 PLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRA 1631

Query: 1868 RRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR 1927
              RR  S S SK RG         + SP+H  KSR  +R   SS + +     +SRTP R
Sbjct: 1632 LPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPK----TKSRTPPR 1687

Query: 1928 RSRSHT-PSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSR 1986
            R  S + P   R++R   R RS S SP  RSRTP R  R+PS  S  P+ +SR+  RR  
Sbjct: 1688 RRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRS 1747

Query: 1987 TPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRS 2046
              S R++T SRR RS S  + R    S  R RR +T   RR  RS   +  SR  +R RS
Sbjct: 1748 ASSPRTKTTSRRGRSPS-PKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRS 1806

Query: 2047 PKRLT 2051
              R+T
Sbjct: 1807 RSRVT 1811



 Score =  129 bits (323), Expect = 4e-29
 Identities = 238/934 (25%), Positives = 362/934 (38%), Gaps = 148/934 (15%)

Query: 1198 EVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP------ 1251
            E  +SP  +S   PE    QS+ S    V ++  +  S      S+  + +P        
Sbjct: 1120 EFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATAS 1179

Query: 1252 PPEPESSITLTPV----ESAVVAEEHEVVP--ERPVTCMVSETPAM-SAEPTVLASEPPV 1304
            PP  +   +  PV    ES++V ++    P  ER       ET    SA PT  +S+   
Sbjct: 1180 PPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPT--SSQDEE 1237

Query: 1305 MSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAP--ESSAMAVLES 1362
            + E  E   S   +G + S +S+ L   + +    +  + E PA++    +S + A LE+
Sbjct: 1238 LMEVVEK--SEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEA 1295

Query: 1363 SAVTVLESSTVTVLESSTVTVLEPSVV---TVPEPPVVAEPDYVTIPVPVVSALEPSVPV 1419
              V  + SS      S     L  S +   +   P        +   +    + E    +
Sbjct: 1296 VEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDL 1355

Query: 1420 LEPAVSVLQ--PSMIVSEPSV-----SVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPM 1472
              P ++ L+  PS+ + E S      S  E +    E A   S Q+   P   A+  TP 
Sbjct: 1356 NGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPS 1415

Query: 1473 ILESSIMSSHVMK-GINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFYESEHGIN 1531
               SS  SS  MK G+  +   ++             SG  P   +   G    S H ++
Sbjct: 1416 RERSSSASSPEMKDGLPRTPSRRS------------RSGSSPGLRD---GSGTPSRHSLS 1460

Query: 1532 IDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTYP---GVSEAD 1588
                                  G+SP       K +P + ++ R+  D+ P    + +  
Sbjct: 1461 ----------------------GSSP-----GMKDIPRTPSRGRSECDSSPEPKALPQTP 1493

Query: 1589 AGETLSSTGP------FALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTEHDMV 1642
               + S + P         + + +G+   ++  T +   L  +     S +    E D+ 
Sbjct: 1494 RPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQR-----SRSGSSQELDVK 1548

Query: 1643 ISTSPSGGSEADIEGPLPAKD-----------IHLDLPSNNNLVSKDTEEPLPVKESDQT 1691
             S SP   SE+D      AK               ++ S + L  + +      +  D+ 
Sbjct: 1549 PSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKP 1608

Query: 1692 LAALLSPKESSGGEKEVPP--PPKETLP--------DSGFSANIEDINEADLVRPLLPKD 1741
             AA   P+  SG +    P  P    LP          G   + E  +  +      PK 
Sbjct: 1609 RAA---PRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKS 1665

Query: 1742 MERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHE 1801
                   R+  E    +    R RS+ S    +   R S  S       E   +    H 
Sbjct: 1666 RTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHR 1725

Query: 1802 KSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQT 1861
            +S    + +  EK +       + S R+K++  + R  + + R   R RS   +     T
Sbjct: 1726 RSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTT 1785

Query: 1862 RSRSRSRRRRRSSRSRSKSRGRRSVSKEKR------KRSPKHRSKSRERKRKRSSSRDNR 1915
            R R RS   + +SR R +SR R  V++ +R       RSP  +  SR   R+R       
Sbjct: 1786 RRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRRGRSRTP 1845

Query: 1916 KTVRARSRT-----PSRRSRSH-TPSRRRRSRS----VGRRRSFS-ISPSRRSRTPSRRS 1964
             T R RSR+     P +RSRS  +P+  RRSRS    + RRRS S  SP  R R+   RS
Sbjct: 1846 PTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRS---RS 1902

Query: 1965 RTPSRRSRTPSRRSRTPSR--RSRTP-----SRRSRTPSRRRRSRS----VVRRRSFS-I 2012
            RT   R R+ SR S    R  RSRTP       RSRTP+ RRRSRS    V RRRS S  
Sbjct: 1903 RTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRT 1962

Query: 2013 SPVRLRRSR---TPLRRRFSR---SPIRRKRSRS 2040
             PV  RRSR   +P+ RR SR   SP+ R+RSRS
Sbjct: 1963 PPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRS 1996



 Score =  127 bits (320), Expect = 1e-28
 Identities = 121/408 (29%), Positives = 177/408 (43%), Gaps = 55/408 (13%)

Query: 1762 GRDRSAASPVVSSMPERA--SESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRD 1819
            GR RS      S  P+R   S S + ++       +   +H +S   + R +     +R 
Sbjct: 523  GRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRG 582

Query: 1820 SS-----LRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR---R 1871
             S      R RS+    +  +SR RT   R R+R R+   +  R+++  R RSR R   R
Sbjct: 583  RSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPAR 642

Query: 1872 RSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTV----RARSRTPSR 1927
            RS RSRS++  RR  S   R R+P  R +SR R   R S R   +T     R+RSRTP R
Sbjct: 643  RSGRSRSRTPARRGRS---RSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRR 699

Query: 1928 ------------RSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS----RRSRTPSRRS 1971
                        RS S TP RR RS S   R++ S +  RRSR+ S    ++SR  SRRS
Sbjct: 700  GRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRS 759

Query: 1972 RT-PSRRSRTPSR---------RSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSR 2021
            R+  S RS+  SR          S  P ++S+TP RR RS S   +      P R R S 
Sbjct: 760  RSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSS 819

Query: 2022 TPLRRRFSRSPIRRKRSRSSE----RGRSPKRLTDLDKAQLLEIAKANAAAMC------- 2070
            +P  ++ S++P R+  S SS     +  +P R   +   Q  E +       C       
Sbjct: 820  SPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDP 879

Query: 2071 -AKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKE 2117
              K+  P   +   + PP ++     +   +       K K I   ++
Sbjct: 880  ELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQ 927



 Score =  109 bits (272), Expect = 4e-23
 Identities = 99/252 (39%), Positives = 126/252 (50%), Gaps = 18/252 (7%)

Query: 1820 SSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTR----SRSRSRRRRRSSR 1875
            S  RSRS+ S  S  +SR RTS +R R+R R+S     RS++R    +R RSR R  ++R
Sbjct: 1884 SRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTR 1943

Query: 1876 SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHT-P 1934
             RS+SR      +  R R+P     +R R R R+S    R++    S    RRSRS T P
Sbjct: 1944 RRSRSRTPPVTRRRSRSRTP---PVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSP 2000

Query: 1935 SRRRRSRS----VGRRRSFS-ISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPS 1989
              RRRSRS    V RRRS S   P+ R R+ SR    P +RSR+ S  +     RSRTP 
Sbjct: 2001 VTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTP- 2059

Query: 1990 RRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRT-PLRRRFSRS---PIRRKRSRSSERGR 2045
            R +R      RS   +RRRS S S     RS T P  R  S S   P+    SR S   R
Sbjct: 2060 RTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSR 2119

Query: 2046 SPKRLTDLDKAQ 2057
                 T LD+ +
Sbjct: 2120 PSMSPTPLDRCR 2131



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 247/1009 (24%), Positives = 392/1009 (38%), Gaps = 206/1009 (20%)

Query: 1201 SSPSEESVSQPEPPVSQSEISEPSA---VPTDYSVSASDP-----SVLVSEAAVTVPEPP 1252
            SSP  +  SQ  P  S+S  S+P A    P   S S+S P     S   S  + +   P 
Sbjct: 782  SSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPH 841

Query: 1253 PEPESSITLTPVESAVV----AEEHEVVPER-------PVTCMVSETPAM-----SAEPT 1296
            P+ +S    TP     +    A E  V P+R       P   + S TP+      S+ P 
Sbjct: 842  PKVKSG---TPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPR 898

Query: 1297 VLASEPPVMSET--------AETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPA 1348
            V +S PP  S +         +   S R   H  S   +   V + TTP  + S+     
Sbjct: 899  VKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSV----- 953

Query: 1349 MAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVP 1408
              +P S+  + L         SS  T ++  T      S    P P V A+    T P P
Sbjct: 954  --SPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ----TPPGP 1007

Query: 1409 VVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVT----VSEPAVTVSEQTQVIPTE 1464
             +S  +   P  +   S++Q           V+ ST          ++ +  Q+Q  P  
Sbjct: 1008 SLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDH 1067

Query: 1465 VAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFY 1524
             +  S+P + +S   S  +      S           + E+A  S   P  ++  +G+F 
Sbjct: 1068 RSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRS---PIRQD--RGEFS 1122

Query: 1525 ES---EHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTY 1581
             S   + G++ +    +   +    + TV +        +G+ + L T+E+K++  L   
Sbjct: 1123 ASPMLKSGMSPE---QSRFQSDSSSYPTVDSNSL-----LGQSR-LETAESKEKMALPPQ 1173

Query: 1582 PGVSEADAGETLSSTGPFALE--PDATGTSKGI------EFTTASTLSLVNKYDVDLSLT 1633
               + A          PF ++  P+++   K        E + A +     + +  L  +
Sbjct: 1174 EDAT-ASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTS 1232

Query: 1634 TQDTEHDMVI--STSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEE------PLPV 1685
            +QD E   V+  S  P+G   + +   L       ++ ++N   S + EE       L  
Sbjct: 1233 SQDEELMEVVEKSEEPAGQILSHLSSELK------EMSTSNFESSPEVEERPAVSLTLDQ 1286

Query: 1686 KESDQTLAALLSPK-ESSGGEKEVPPPPKE------------------------TLPDSG 1720
             +S  +L A+  P   SS G     P  KE                        T  ++G
Sbjct: 1287 SQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTG 1346

Query: 1721 FSANIEDINEADLVRPLLPK-------DMERLTSLRAGIEGPLLASD------VGRDRSA 1767
            FS+ +++    DL  P L +       DM+  ++  +G     L+ D      +  ++S 
Sbjct: 1347 FSSEVKE----DLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSI 1402

Query: 1768 ASPVVSSMP-----ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDS-- 1820
            +SPV+ ++P     ER+S +SS E  D     +      +S  +     G     R S  
Sbjct: 1403 SSPVLDAVPRTPSRERSSSASSPEMKDG--LPRTPSRRSRSGSSPGLRDGSGTPSRHSLS 1460

Query: 1821 ------------SLRSRSKRSKSSEHKSRKRTSESRSRA--------------RKRSSKS 1854
                          R RS+   S E K+  +T   RSR+              R+RS   
Sbjct: 1461 GSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSE 1520

Query: 1855 KSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKR---SPKHRSKSRERKRKRSSS 1911
             S   +T +R+   +R RS  S+     + S S ++R     SP  ++K+R   R+RS S
Sbjct: 1521 SSVDQKTVARTPLGQRSRSGSSQELD-VKPSASPQERSESDSSPDSKAKTRTPLRQRSRS 1579

Query: 1912 RDNRKTVRARSRTPSRRSRS-HTPSRRRRSRSVGRRRSFS-ISPSRRSRTP---SRRSRT 1966
              + + V ++SR   RRSRS  +P  + + R+  R +S S  SP  ++  P    RRSR+
Sbjct: 1580 GSSPE-VDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRS 1638

Query: 1967 -PSRRSRTP-----------------SRRSRTPSRRSRTPSRRSRTPSRRRRSRSV---- 2004
              S + R P                 SR +R  SR S  P  +SRTP RRR SRS     
Sbjct: 1639 GSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELT 1698

Query: 2005 ----VRRRSFSISPVRLRRSRTPLRRRFS---RSPIRRKRSRSSERGRS 2046
                + RRS S S     RSRTP R R S    SP   ++SRSS R RS
Sbjct: 1699 RKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRS 1747



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 102/332 (30%), Positives = 141/332 (42%), Gaps = 29/332 (8%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            R RS ASP         +   S  +        V     +S+ +  R +        S  
Sbjct: 1863 RSRSRASPATHRRSRSRTPLISRRRSRSRTS-PVSRRRSRSRTSVTRRRSRSRASPVSRR 1921

Query: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRS---RSK 1879
            RSRS+    +  +SR RT  +R R+R R+      RS++R+   +RRR RS  S   R +
Sbjct: 1922 RSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRR 1981

Query: 1880 SRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTP---SRRSRSHTP-S 1935
            SR R S    +R RS +    +R R R R+S    R   R+RSRTP    RRSRS TP  
Sbjct: 1982 SRSRTSPVTRRRSRS-RTSPVTRRRSRSRTSPVTRR---RSRSRTPPAIRRRSRSRTPLL 2037

Query: 1936 RRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTP 1995
             R+RSRS   R   +I    RSRTP       S     P+ R R+ S  S   SR +  P
Sbjct: 2038 PRKRSRS---RSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPP 2094

Query: 1996 SRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDK 2055
            + R  S S          PV L  SR     R S SP         +R RSP  L  L  
Sbjct: 2095 ATRNHSGS-------RTPPVALNSSRMSCFSRPSMSP------TPLDRCRSPGMLEPLGS 2141

Query: 2056 AQL-LEIAKANAAAMCAKAGVPLPPNLKPAPP 2086
            ++  + + +    +M    G  +P + + + P
Sbjct: 2142 SRTPMSVLQQAGGSMMDGPGPRIPDHQRTSVP 2173



 Score = 87.0 bits (214), Expect = 2e-16
 Identities = 91/416 (21%), Positives = 167/416 (40%), Gaps = 46/416 (11%)

Query: 1681 EPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPK 1740
            E   ++E   T   +L  K+ + G KE  P  +  + ++     + ++NE         K
Sbjct: 83   EEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETH---QLAELNE---------K 130

Query: 1741 DMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTH 1800
              ERL +   GI      SD   D S+  P        A + + E    Y +  +   + 
Sbjct: 131  KNERLRAA-FGI------SDSYVDGSSFDP--QRRAREAKQPAPEPPKPYSLVRESSSSR 181

Query: 1801 EKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQ 1860
              + K K + K +   +R  S   R +R KSS+ K  +  SES    +KR  +S + +S+
Sbjct: 182  SPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESES----KKRKHRSPTPKSK 237

Query: 1861 TRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRA 1920
             +S+ + R+R RS+    KSR               HRS S +      +SR   ++  A
Sbjct: 238  RKSKDKKRKRSRSTTPAPKSR-------------RAHRSTSADSASSSDTSRSRSRSAAA 284

Query: 1921 RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSR--RSRTPSRRS 1978
            ++ T +   RS +P+  RR            + ++R  +P   ++ PS     +   ++ 
Sbjct: 285  KTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKE 344

Query: 1979 RTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRS 2038
            ++ +R S +P R S  P     +  +  R   S  P+    + TPL +     P     +
Sbjct: 345  KSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPL----ATTPLSQEPVNPPSEASPT 400

Query: 2039 RSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVA 2094
            R     +SP++L     ++      +      ++     P + KPAP P    +++
Sbjct: 401  RDRSPPKSPEKLPQSSSSE--SSPPSPQPTKVSRHASSSPESPKPAPAPGSHREIS 454



 Score = 78.6 bits (192), Expect = 7e-14
 Identities = 101/322 (31%), Positives = 149/322 (46%), Gaps = 65/322 (20%)

Query: 1773 SSMPERA--SESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSK 1830
            S  P+R   S SSSE K+      K + +  +S+ N +    E +K R SS RSRS  S 
Sbjct: 715  SRTPQRRGRSGSSSERKN------KSRTSQRRSRSNSSP---EMKKSRISSRRSRSLSSP 765

Query: 1831 SSEHKSRKRTSES----------RSRARKRSSKSKSHRSQTRSRSRSRRRRRSS----RS 1876
             S+ KSR     S          +S+   R S+S S + + +SR+  RR R SS    + 
Sbjct: 766  RSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQ 825

Query: 1877 RSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTV--------------RARS 1922
            +SK+  R+S S       PK +S +  R+   +S + N ++V                +S
Sbjct: 826  KSKTPSRQSHSSSSPH--PKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKS 883

Query: 1923 RTPSRRS---------RSHTPSRRRRSRSVGRRRSFS--ISPSRRSRTPSRRSRTPSR-R 1970
            RTPSR S         +S TP R+  SRS   +      ISP +RS + S  S +PSR  
Sbjct: 884  RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSS-SPSPSRVT 942

Query: 1971 SRTPSRRSRTPSRRSRTPSR--------RSRTPSRRRRSRSVVRR-RSFSISPVRLRRSR 2021
            SRT  RRSR+ S  S   SR         S +P  + +  +  R+  S SISP    +++
Sbjct: 943  SRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ 1002

Query: 2022 TPLRRRF--SRSPIRRKRSRSS 2041
            TP       S+SP  +++S+ S
Sbjct: 1003 TPPGPSLSGSKSPCPQEKSKDS 1024



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 126/534 (23%), Positives = 195/534 (36%), Gaps = 79/534 (14%)

Query: 1676 SKDTEEPLPVKESDQTLAALLSPKESSGGE--KEVPPPPKETLPDSGFSANIEDINEADL 1733
            +K+    LP    D+ L  ++   E   G+    +    KE +  S F ++ E + E   
Sbjct: 1222 TKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKE-MSTSNFESSPE-VEERPA 1279

Query: 1734 VRPLLPKDMERLTSLRAGIEGPLLASDVG----------------RDRSAASPVV--SSM 1775
            V   L +   +  SL A +E P +AS  G                R+ S  SP+   +S 
Sbjct: 1280 VSLTLDQSQSQ-ASLEA-VEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSG 1337

Query: 1776 P---ERASESSSEEKDDYE-IFVKVKDTHEK--SKKNKNRDKGEKEKKRDSSLRSRSKRS 1829
            P   E  +  SSE K+D    F+   +T      K+   R  G    +       ++  S
Sbjct: 1338 PLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMS 1397

Query: 1830 KSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKE 1889
             +    S    +  R+ +R+RSS + S   +        RR RS  S     G  + S+ 
Sbjct: 1398 SNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRH 1457

Query: 1890 KRK-RSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRS-HTPSRRRRSRSVGRRR 1947
                 SP  +   R   R RS   D+    +A  +TP  RSRS  +P    +  +  R R
Sbjct: 1458 SLSGSSPGMKDIPRTPSRGRSEC-DSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRER 1516

Query: 1948 S---FSISPSRRSRTP-SRRSRTPS------RRSRTPSRRSRTPS-----RRSRTP---- 1988
            S    S+     +RTP  +RSR+ S      + S +P  RS + S      ++RTP    
Sbjct: 1517 SGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQR 1576

Query: 1989 SRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFS------------RSPIRRK 2036
            SR   +P    +SR   RR     SP    + R   R +              R+  RR 
Sbjct: 1577 SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRS 1636

Query: 2037 RSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKK 2096
            RS SS +GR P            E    +  A       P P      PP        ++
Sbjct: 1637 RSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPP--------RR 1688

Query: 2097 SGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKP 2150
                +  ELT K +   +S+       +     +     PP +     +S P+P
Sbjct: 1689 RSSRSSPELTRKARLSRRSR-------SASSSPETRSRTPPRHRRSPSVSSPEP 1735



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 85/332 (25%), Positives = 121/332 (36%), Gaps = 40/332 (12%)

Query: 1682 PLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSG-----FSANIEDINEADLVRP 1736
            P+P   SDQ+   +      +G +         T   +G      S     +  +D+  P
Sbjct: 2450 PVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEP 2509

Query: 1737 LLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKV 1796
                  ++ ++L A        S      S++S   SS    +S SS     D E     
Sbjct: 2510 PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLP 2569

Query: 1797 KDTHEKSKKNKNRDKGEKEKKRDS-----SLRSRSKRSKSSEHKSRKRTSESRSRARKRS 1851
                   K+  +     KE  R+      +   R +RS SS   S   +S S S +   S
Sbjct: 2570 VQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSS 2629

Query: 1852 SKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSS 1911
            S S S  S + S S S     SS S +K   +        K+ P    +SR  ++   S 
Sbjct: 2630 SSSSSSSSSSSSSSSS----SSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSL 2685

Query: 1912 RDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRS 1971
            RD+             RS S++P  RRR          S  PS R +  S   R  SRR 
Sbjct: 2686 RDS-------------RSLSYSPVERRRP---------SPQPSPRDQQSSSSER-GSRRG 2722

Query: 1972 RTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRS 2003
            +    RS +  RR  TPS R   P R R SRS
Sbjct: 2723 QRGDSRSPSHKRRRETPSPR---PMRHRSSRS 2751



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 67/209 (32%), Positives = 82/209 (39%), Gaps = 10/209 (4%)

Query: 1842 ESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS 1901
            E RS +   SS S S  S + S S S     SS S   S   +     KR  SP    K 
Sbjct: 2529 ERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKE 2588

Query: 1902 RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961
              R+      R    T   R R  S  S S + S    S S     S S S S  S + S
Sbjct: 2589 AVRE-----GRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643

Query: 1962 RRSRTPSRRSRTPSRRSRTPSRRSRTPS-RRSRTPSRRRRSRSVVRRRSFSISPVRLRRS 2020
              S +PS     P    +  S +   P  RRSR+P  R+   S+   RS S SPV  RR 
Sbjct: 2644 SSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSP--RKPIDSLRDSRSLSYSPVERRRP 2701

Query: 2021 RTPLRRRFSRSPIRRKRSRSSERG--RSP 2047
                  R  +S    + SR  +RG  RSP
Sbjct: 2702 SPQPSPRDQQSSSSERGSRRGQRGDSRSP 2730



 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 95/443 (21%), Positives = 164/443 (37%), Gaps = 84/443 (18%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            R  S+     S  P R S SSS      +     + +H  S  +     G   ++   + 
Sbjct: 798  RSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITS 857

Query: 1823 RSRSKRSKSSEHKSRKRTS-ESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSR 1881
               +++S + + +S   +S +   ++R  S  S S  S  R +S +  R+  SRS S   
Sbjct: 858  PQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQP 917

Query: 1882 GRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNR-----KTVRAR---------SRTPSR 1927
              +++   +++      S S  R   R++ R +R       V +R         S +P  
Sbjct: 918  KVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDT 977

Query: 1928 RSRSHTPSRRRRSRSV------------GRRRSFSISPSRRSRT--------PSRRSRTP 1967
            + +  TP R+  S S+            G   S S SP  + ++        P   S   
Sbjct: 978  KVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCA 1037

Query: 1968 SRRSRTPSRRS--------------RTPSRRSRTPS-----RRSRTPSRRRRSRSVVR-R 2007
              +S TP   S               +P  RS T S       S +PS + +S++  +  
Sbjct: 1038 GVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGG 1097

Query: 2008 RSFSISPVRLRRSRTPLRR---RFSRSPIRRKRSRSSERGR---SPKRLTDLDKAQLLEI 2061
            RS S SPV    SR+P+R+    FS SP+  K   S E+ R          +D   LL  
Sbjct: 1098 RSRSSSPVTELASRSPIRQDRGEFSASPM-LKSGMSPEQSRFQSDSSSYPTVDSNSLLGQ 1156

Query: 2062 AKANAAAMCAKAGVPLPPNLKPAPP----------------------PTIEEKVAKKSGG 2099
            ++   A    K  +P   +   +PP                       T+     ++SG 
Sbjct: 1157 SRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGA 1216

Query: 2100 ATIEELTEKCKQIAQSKEDDDVI 2122
             +  E  E+   +  S +D++++
Sbjct: 1217 GSSPETKEQNSALPTSSQDEELM 1239



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 174/864 (20%), Positives = 283/864 (32%), Gaps = 126/864 (14%)

Query: 1022 RSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMS---------AYERSMMSAYER 1072
            RS  SP+  R   S     +     RS  SP+  R   S         +  R+ +   +R
Sbjct: 1983 RSRTSPVTRRRSRSRTS-PVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKR 2041

Query: 1073 SMM-SPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADS 1131
            S   SP+A R        RS     +   RS+  S  A  R   S  ++DRS  +    +
Sbjct: 2042 SRSRSPLAIRRR-----SRSRTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPAT 2096

Query: 1132 YTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEE---PPMTPPLPPEEPP----------- 1177
               S + T   A     +     P+M P P +    P M  PL     P           
Sbjct: 2097 RNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGSM 2156

Query: 1178 ---EGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSA 1234
                GP +P  Q     EN   + +  + +  S+    PP S               +SA
Sbjct: 2157 MDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPS---------------MSA 2201

Query: 1235 SDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAE 1294
            +  +  +S+       P P P  S+   P  +                 + S  PA SA 
Sbjct: 2202 AGLAARMSQV------PAPVPLMSLRTAPAAN-----------------LASRIPAASAA 2238

Query: 1295 PTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPES 1354
               LAS       TA      R     A+  + +L  P       A ++ +P    AP  
Sbjct: 2239 AMNLASARTPAIPTAVNLADSRTP---AAAAAMNLASPRTAVAPSAVNLADPRTPTAPAV 2295

Query: 1355 SAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAE---PDYVTIPVPVVS 1411
            +       +A+  L   ++T   +       PS    P+ P  A    P       PV  
Sbjct: 2296 NLAGARTPAALAAL---SLTGSGTPPTAANYPSSSRTPQAPASANLVGPRSAHATAPVNI 2352

Query: 1412 ALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
            A   +   L PA S+    M  +    ++    V +S         +  +       + P
Sbjct: 2353 AGSRTAAALAPA-SLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPP 2411

Query: 1472 MILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFYESEHGIN 1531
                 S M+S      +   G    AP    Q +   + ++P +   +   F +    + 
Sbjct: 2412 SAPSQSRMTSERAPSPSSRMGQ---APS---QSLLPPAQDQPRSP--VPSAFSDQSRCL- 2462

Query: 1532 IDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTYPGVSEADAGE 1591
              +     +   +   +   A  TS  G+      +P             PGV  +D GE
Sbjct: 2463 --IAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPA------------PGVPHSDVGE 2508

Query: 1592 TLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQDTEHDMVISTSPSGGS 1651
              +STG  A +P A    +  +   +S+ S  +      S ++  +      S+S S GS
Sbjct: 2509 PPASTG--AQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGS 2566

Query: 1652 EADIEGPLPAKDIHLDLPSNNNLVSKD-TEEPLPVKESDQTLAALLSPKESSGGEKEVPP 1710
               ++  +  K +    P+    V +    EP P K   ++ ++  S   SS        
Sbjct: 2567 SLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSS 2626

Query: 1711 PPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASP 1770
                +   S  S++    + +    P   K   +     A  + P       R RS   P
Sbjct: 2627 SSSSSSSSSSSSSSSSSSSSSS---PSPAKPGPQALPKPASPKKP--PPGERRSRSPRKP 2681

Query: 1771 VVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSK 1830
            + S    R+   S  E+               S +   RD+     +R  S R +   S+
Sbjct: 2682 IDSLRDSRSLSYSPVER------------RRPSPQPSPRDQQSSSSER-GSRRGQRGDSR 2728

Query: 1831 SSEHKSRKRTSESRSRARKRSSKS 1854
            S  HK R+ T   R   R RSS+S
Sbjct: 2729 SPSHKRRRETPSPRP-MRHRSSRS 2751



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 90/387 (23%), Positives = 150/387 (38%), Gaps = 36/387 (9%)

Query: 1752 IEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDK 1811
            I  P   S  G    + S V S    R S S S    + E  +  + +H  S     + K
Sbjct: 922  IISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSP-CSNVESRLLPRYSHSGSSSPDTKVK 980

Query: 1812 GEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRR 1871
             E   ++  S          ++       S S+S   +  SK    +S   S S     +
Sbjct: 981  PETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVK 1040

Query: 1872 RSSRSRSKSRGRRSVS-KEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSR 1930
             S+       G  S+  K + + SP HRS +   + ++S S       ++++     RSR
Sbjct: 1041 SSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSR 1100

Query: 1931 SHTPSRRRRSRSVGR--RRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTP 1988
            S +P     SRS  R  R  FS SP  +S     +SR  S  S  P+  S +   +SR  
Sbjct: 1101 SSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLE 1160

Query: 1989 SRRSR----TPSRRRRSRSVVRRR-SFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSER 2043
            +  S+     P +   + S  R++  FS  PV+ R   + + +   R+P R +    S  
Sbjct: 1161 TAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRER----SGA 1216

Query: 2044 GRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIE 2103
            G SP            E  + N+A         LP + +      + EK +++  G  + 
Sbjct: 1217 GSSP------------ETKEQNSA---------LPTSSQDEELMEVVEK-SEEPAGQILS 1254

Query: 2104 ELTEKCKQIAQSK-EDDDVIVNKPHVS 2129
             L+ + K+++ S  E    +  +P VS
Sbjct: 1255 HLSSELKEMSTSNFESSPEVEERPAVS 1281



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 59/242 (24%), Positives = 91/242 (37%), Gaps = 27/242 (11%)

Query: 107 KSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVA 166
           K +KH+    K K+K K+K++K  R    +    ++H   + D  S S        SA A
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAA 284

Query: 167 LELPTRAFGPSET------NESPAVVLEPPVVSMEVSEPHILETLKPAT----KTAELSV 216
               T   G S +       E  A   EP   S +        T +P++    K  +   
Sbjct: 285 KTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKE 344

Query: 217 VSTSVISEQSEQSVAVMPEPSMTKIL-DSFAAAPVPTTTLVLKSSEPVVTMSV------E 269
            S +  S   E+S      P+ T +L +    +P P  T  L S EPV   S        
Sbjct: 345 KSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPL-SQEPVNPPSEASPTRDR 403

Query: 270 YQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFP 329
              KS  K  +S+S E S      PP     +P++    +S +P    P P+  +  +  
Sbjct: 404 SPPKSPEKLPQSSSSESS------PPSP---QPTKVSRHASSSPESPKPAPAPGSHREIS 454

Query: 330 ES 331
            S
Sbjct: 455 SS 456



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 71/324 (21%), Positives = 114/324 (35%), Gaps = 49/324 (15%)

Query: 947  DPYRLGHDPYRLTPDPYRMSPRPYRIAPRSYRI-APRPYRLAPRPLMLASRRSMMMSYAA 1005
            DP R   +  +  P+P    P+PY +   S    +P P +   +      RRS   S   
Sbjct: 152  DPQRRAREAKQPAPEP----PKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRR 207

Query: 1006 ERSMMSSYERSMMSYE---RSMMSPMAERSMMSAYERSMMSAY-------ERSMMSPMAE 1055
            ER   S  ++     E   R   SP  +    S  ++   S          R+  S  A+
Sbjct: 208  ERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSAD 267

Query: 1056 RSMMSAYERSMM-SAYERSMMSPMADRSMMSMGADR----SMMSSYSAADRSMMSSYSAA 1110
             +  S   RS   SA  ++  + +A RS       R    +  S          SS   A
Sbjct: 268  SASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETA 327

Query: 1111 DRSMMSSYT---ADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEE----PPTMPPLPPE 1163
             +   S Y     D+   S    S +   + T  E     PL  E     P  +   P  
Sbjct: 328  TKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLS 387

Query: 1164 EPPMTPPL---------PPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPP 1214
            + P+ PP          PP+ P + P       + ++E++ P+  P+  S  + S PE P
Sbjct: 388  QEPVNPPSEASPTRDRSPPKSPEKLP------QSSSSESSPPSPQPTKVSRHASSSPESP 441

Query: 1215 VSQSEISEPSAVPTDYSVSASDPS 1238
                   +P+  P  +   +S P+
Sbjct: 442  -------KPAPAPGSHREISSSPT 458



 Score = 37.7 bits (86), Expect = 0.13
 Identities = 72/290 (24%), Positives = 107/290 (36%), Gaps = 40/290 (13%)

Query: 95  VQTDPTDEIPTKKSKKHKKHKNKKKKK-----KKEKEK--KYKRQPEESESKTKSHDDGN 147
           V+   +   PT K KK KK K++ ++      ++E++K  K K+   ESESK + H    
Sbjct: 174 VRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPT 233

Query: 148 IDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKP 207
              +  S  K      +      +R    S + +S +        S + S      +   
Sbjct: 234 PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSAS--------SSDTSRSR-SRSAAA 284

Query: 208 ATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMS 267
            T T  L+  S S  S +  +  A   EP  T         P    T   + S P     
Sbjct: 285 KTHTTALAGRSPSPASGRRGEGDAPFSEPGTTS-----TQRPSSPETATKQPSSPYEDKD 339

Query: 268 VEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVL---------EPSETLVVSSE---TPTE 315
            + + KS  +   S SPE S     EPP    L         +P  T  +S E    P+E
Sbjct: 340 KDKKEKSATR--PSPSPERSSTG-PEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSE 396

Query: 316 VYPEPSTS---TTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELP 362
             P    S   +    P+SS+ E+     QP  V S  A SS   P+  P
Sbjct: 397 ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKV-SRHASSSPESPKPAP 445



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 72/316 (22%), Positives = 113/316 (35%), Gaps = 51/316 (16%)

Query: 99  PTDEIPTKKSKKHKKHKNKKKKKKKEK----EKKYKRQPEESESKTKSHDDGNIDLESDS 154
           P   +    S +    K KKKKKKK++    E    R+  +  SK K H       ES+S
Sbjct: 170 PYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRS-----ESES 224

Query: 155 FLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAEL 214
             +    P+  +             + +PA        S         +T +  +++A  
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAA 284

Query: 215 SVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTM---SVEYQ 271
              +T++            P P+  +  +  A    P TT   + S P       S  Y+
Sbjct: 285 KTHTTALAGRS--------PSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYE 336

Query: 272 MKSVLKSVES-TSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPE 330
            K   K  +S T P PS       P      P+ T +++        P+P  +T      
Sbjct: 337 DKDKDKKEKSATRPSPSPERSSTGPE----PPAPTPLLAERHGGS--PQPLATTP----- 385

Query: 331 SSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPP--- 387
                   L ++PV+ PSE   +S TR +  P+ P+      Q SS  S+   P P    
Sbjct: 386 --------LSQEPVNPPSE---ASPTRDRSPPKSPEKLP---QSSSSESSPPSPQPTKVS 431

Query: 388 --ATSMPELQGPPVTP 401
             A+S PE   P   P
Sbjct: 432 RHASSSPESPKPAPAP 447



 Score = 35.4 bits (80), Expect = 0.65
 Identities = 59/257 (22%), Positives = 82/257 (31%), Gaps = 59/257 (22%)

Query: 1051 SPMAERSMMSAYE--RSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYS 1108
            SP  ER   S  +  RS   + +R   SP       S    R    S + A +S  +  S
Sbjct: 204  SPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRS 263

Query: 1109 AADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMT 1168
             +  S  SS T+     S AA ++T +                       P P       
Sbjct: 264  TSADSASSSDTSRSRSRSAAAKTHTTALAGR------------------SPSPASGRRGE 305

Query: 1169 PPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPT 1228
               P  EP                 T  T+ PSSP E +  QP  P    +  +      
Sbjct: 306  GDAPFSEP----------------GTTSTQRPSSP-ETATKQPSSPYEDKDKDK------ 342

Query: 1229 DYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSE- 1287
                          E + T P P PE  S+    P  + ++AE H   P+   T  +S+ 
Sbjct: 343  -------------KEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQE 389

Query: 1288 --TPAMSAEPTVLASEP 1302
               P   A PT   S P
Sbjct: 390  PVNPPSEASPTRDRSPP 406



 Score = 35.0 bits (79), Expect = 0.85
 Identities = 130/632 (20%), Positives = 210/632 (33%), Gaps = 136/632 (21%)

Query: 958  LTPDPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMM---SSYE 1014
            L P     S  P  I  RS    PR  R          +RS+  S  A R      SS +
Sbjct: 2036 LLPRKRSRSRSPLAIRRRSRSRTPRTAR---------GKRSLTRSPPAIRRRSASGSSSD 2086

Query: 1015 RSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPM---------------AERSMM 1059
            RS  +   +  +    R+   A   S MS + R  MSP                + R+ M
Sbjct: 2087 RSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPM 2146

Query: 1060 SAYER---SMMSA-------YER----------------------------SMMSPMADR 1081
            S  ++   SMM         ++R                            SM +     
Sbjct: 2147 SVLQQAGGSMMDGPGPRIPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSAAGLAA 2206

Query: 1082 SMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMA---ADSYTDSYTD 1138
             M  + A   +MS  +A   ++ S   AA  + M+  +A    +  A   ADS T +   
Sbjct: 2207 RMSQVPAPVPLMSLRTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAA 2266

Query: 1139 TYTEAYMVPPLPPEEPPTMPPLPPEEPPM--------------------TPPLPPEEP-- 1176
                A     + P       P  P  P +                    TPP     P  
Sbjct: 2267 AMNLASPRTAVAPSAVNLADPRTPTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSS 2326

Query: 1177 ---PEGPALPTEQSALTAENTWPTEVPSS-------PSEESVSQPEPPVSQSEISEPSAV 1226
               P+ PA        +A  T P  +  S       P+  + ++  P +S + ++ P   
Sbjct: 2327 SRTPQAPASANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVP 2386

Query: 1227 PTDYS--VSASDPSVLVSEAAVTVPEPP----------PEPESSITLTPVESAVVAEEHE 1274
             + Y      + P +L    + T P  P          P P S +   P +S +   + +
Sbjct: 2387 LSAYERVSGRTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQ 2446

Query: 1275 VVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAV 1334
              P  PV    S+         ++A   PV    + +  ++  +   A + +  L VPA 
Sbjct: 2447 --PRSPVPSAFSD-----QSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAP 2499

Query: 1335 TTPVLAESILEPPA-MAAPESSAMAVLE-------------SSAVTVLESSTVTVLESST 1380
              P     + EPPA   A + SA+A L+             SS+ +   SS+ +   SS 
Sbjct: 2500 GVP--HSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSG 2557

Query: 1381 VTVLEPSVVTVPEPPVVAEPDYVT-IPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVS 1439
             +  +    ++P  P VA     +  P P  +  E   P   PA    + S   S  S S
Sbjct: 2558 SSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSS 2617

Query: 1440 VQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
               S+ + S  + + S  +    +  +  S+P
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSP 2649



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 46/238 (19%), Positives = 82/238 (34%), Gaps = 6/238 (2%)

Query: 213  ELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQM 272
            E   VS ++   QS+ S+  +  PSM         +P           E      +E++ 
Sbjct: 1276 ERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRN 1335

Query: 273  KSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESS 332
               L +  +T         +  P    LE   +L +  ++ T      S+  + D  E +
Sbjct: 1336 SGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQS-TRSSGHSSSELSPDAVEKA 1394

Query: 333  AIEALRLPEQPV-----DVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPP 387
             + + +    PV       PS    SS + P+    LP+T +   +  S     +  G P
Sbjct: 1395 GMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTP 1454

Query: 388  ATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTP 445
            +        P +  +   P    +     P P + P    P   + + PEL    +TP
Sbjct: 1455 SRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTP 1512



 Score = 32.3 bits (72), Expect = 5.5
 Identities = 53/266 (19%), Positives = 95/266 (35%), Gaps = 18/266 (6%)

Query: 176  PSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPE 235
            PS  ++S       P  S  + +      L PA       V S       S+QS  ++ +
Sbjct: 2411 PSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAF-----SDQSRCLIAQ 2465

Query: 236  PSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTS--PEPSKIMLVE 293
             +      S ++  V TTT        ++++       S +    +++   +PS +  ++
Sbjct: 2466 TTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQ 2525

Query: 294  PPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQP------VDVP 347
            P   +    S +   SS + +      S+S++     SS  E   LP QP      V  P
Sbjct: 2526 PAKERRSSSSSS---SSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582

Query: 348  SEIADSSMT--RPQELPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLEL 405
            +     ++   RP E     +        SS +S+       ++S         +     
Sbjct: 2583 TPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2642

Query: 406  PGPSATPVPELPGPLSTPVPELPGPP 431
               S++P P  PGP + P P  P  P
Sbjct: 2643 SSSSSSPSPAKPGPQALPKPASPKKP 2668



 Score = 32.0 bits (71), Expect = 7.2
 Identities = 78/383 (20%), Positives = 129/383 (33%), Gaps = 53/383 (13%)

Query: 233  MPEPSMTKILDSFAAAPVPT--TTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIM 290
            +P+   T + ++ A + +    T + L ++ P  +MS      + L +  S  P P  +M
Sbjct: 2164 IPDHQRTSVPENHAQSRIALALTAISLGTARPPPSMSA-----AGLAARMSQVPAPVPLM 2218

Query: 291  -LVEPPVAKVLE--PSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVP 347
             L   P A +    P+ +    +         P+     D    +A  A+ L      V 
Sbjct: 2219 SLRTAPAANLASRIPAASAAAMNLASARTPAIPTAVNLADSRTPAAAAAMNLASPRTAVA 2278

Query: 348  SEIADSSMTRPQELPELPKTTALELQESSVASAMELPG----PPATSMPELQGPPVTPV- 402
                + +  R    P  P       +  +  +A+ L G    P A + P     P  P  
Sbjct: 2279 PSAVNLADPRT---PTAPAVNLAGARTPAALAALSLTGSGTPPTAANYPSSSRTPQAPAS 2335

Query: 403  LELPGP-------------SATPVPELPGPLSTP--VPELPGP-------PATAVPELPG 440
              L GP             S T     P  L++    P L G        P +A   + G
Sbjct: 2336 ANLVGPRSAHATAPVNIAGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSG 2395

Query: 441  PSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVA 500
             +  P+   ++      APS      +  P P     + P   L+  A + P  P   V 
Sbjct: 2396 RTSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSP---VP 2452

Query: 501  MELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALEL 560
               ++Q         PV  +     G   V T T   G     + +  PG P +    ++
Sbjct: 2453 SAFSDQSRCLIAQTTPVAGSQSLSSG--AVATTTSSAGDHNGMLSVPAPGVPHS----DV 2506

Query: 561  PGQPSVTGVPELPGLPSATRALE 583
               P+ TG  +    PSA  AL+
Sbjct: 2507 GEPPASTGAQQ----PSALAALQ 2525


>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
          Length = 1007

 Score =  125 bits (314), Expect = 5e-28
 Identities = 107/309 (34%), Positives = 151/309 (48%), Gaps = 40/309 (12%)

Query: 1764 DRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLR 1823
            D+  +   +  + E+ + S S+E+         K +   SK++K++D+  K K      R
Sbjct: 197  DKKKSKGGIEIVKEKTTRSKSKER---------KKSKSPSKRSKSQDQARKSKSPTLRRR 247

Query: 1824 SRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGR 1883
            S+ K  K+      K   E +S+++ R  K     +++RSR R ++ R     R KS+ R
Sbjct: 248  SQEKIGKARSPTDDKVKIEDKSKSKDR--KKSPIINESRSRDRGKKSRSPVDLRGKSKDR 305

Query: 1884 RSVSKE---KRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTP---SRR 1937
            RS SKE   KR  + K +   +   +  SS ++NR   R   R+P RRS S  P   SRR
Sbjct: 306  RSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRR 365

Query: 1938 RRSRSVGRRRSFSISPSRRSRTPSRR--SRTPSRRSRTPSRRSRTPSR------------ 1983
             RS  +  RRS       R+ +P RR  SR+  R+ R P RR  +  R            
Sbjct: 366  SRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRE 425

Query: 1984 RSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRR---KRSRS 2040
            RS+  S  +R    RRRSRS +RRRS S     LRRSR+P RR  SRSP RR   +RSRS
Sbjct: 426  RSKDASPINRWSPTRRRSRSPIRRRSRS----PLRRSRSPRRR--SRSPRRRDRGRRSRS 479

Query: 2041 SERGRSPKR 2049
              R RS  R
Sbjct: 480  RLRRRSRSR 488



 Score =  120 bits (301), Expect = 2e-26
 Identities = 135/422 (31%), Positives = 196/422 (46%), Gaps = 98/422 (23%)

Query: 1705 EKEVPPPPKETLPDSGFSANIEDIN-EADLVRPLLPKDMERLTSLRAGIEGPLLASDVGR 1763
            +KE   P K T  D    A +ED+  +  L++  L  ++     +++G+   L   + G 
Sbjct: 88   DKEGMSPAKRTKLDD--LALLEDLEKQRALIKAELDNELME-GKVQSGMGLILQGYESGS 144

Query: 1764 DRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSK-KNKNRDKGEKEKKRDSS- 1821
            +        +    R+S  SS  K   E+      T ++SK ++K R +   +KK+    
Sbjct: 145  EEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGG 204

Query: 1822 ---LRSRSKRSKSSEHKSRK---RTSESRSRARKRSSKSKSHRSQTR------------- 1862
               ++ ++ RSKS E K  K   + S+S+ +ARK  S +   RSQ +             
Sbjct: 205  IEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVK 264

Query: 1863 --SRSRSRRRRRS---SRSRSKSRGRRSVSK-EKRKRSPKHRSKSRERKRKRS------- 1909
               +S+S+ R++S   + SRS+ RG++S S  + R +S   RS+S+ERK KRS       
Sbjct: 265  IEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKK 324

Query: 1910 ----------SSRDNRKTVRARSRTPSRRSRSHTP---SRRRRSRSVGRRRSF------- 1949
                      S ++NR   R   R+P RRS S  P   SRR RS  +  RRS        
Sbjct: 325  PIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSR 384

Query: 1950 SISPSRR--SRTPSRRSRTP-----------------SRRSRTPS-----------RRSR 1979
            ++SP RR  SR+  R+ R P                 SRR R+             RRSR
Sbjct: 385  TLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSR 444

Query: 1980 TP-SRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRS 2038
            +P  RRSR+P RRSR+P  RRRSRS  RR        R RRSR+ LRRR      RR+RS
Sbjct: 445  SPIRRRSRSPLRRSRSP--RRRSRSPRRRD-------RGRRSRSRLRRRSRSRGGRRRRS 495

Query: 2039 RS 2040
            RS
Sbjct: 496  RS 497



 Score =  114 bits (285), Expect = 1e-24
 Identities = 117/347 (33%), Positives = 165/347 (47%), Gaps = 95/347 (27%)

Query: 1781 ESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRT 1840
            ES SEE+ +          HEK++       G +   R SS + + +   +     ++  
Sbjct: 141  ESGSEEEGEI---------HEKARN------GNRSSTRSSSTKGKLELVDNKITTKKRSK 185

Query: 1841 SESRSRARKRSSKSKS-------HRSQTRSRSRSRRRRRSSRSRSKSRG----------- 1882
            S S+ R R RS K KS           TRS+S+ R++ +S   RSKS+            
Sbjct: 186  SRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLR 245

Query: 1883 RRSVSKEKRKRSP-------KHRSKSRERKR----KRSSSRDNRKTVRA----------- 1920
            RRS  K  + RSP       + +SKS++RK+      S SRD  K  R+           
Sbjct: 246  RRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDR 305

Query: 1921 RSRTPSRRS-RSHTPSRRRRSRSVGRRRSF---SISPSRR-SRTPSRRSRTP-----SRR 1970
            RSR+  R+S RS T   ++  +S  +  S    + SPSRR  R+P RRS +P     SRR
Sbjct: 306  RSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRR 365

Query: 1971 SRTP------SRRSRTPSR--------RSRTPSRRSRTPSRRR------RSRSVV---RR 2007
            SR+P      S++S++PSR        +SR+  R+ R P RRR      R R  +   R 
Sbjct: 366  SRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRE 425

Query: 2008 RSFSISPVR-----LRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKR 2049
            RS   SP+       RRSR+P+RRR SRSP+RR RS    R RSP+R
Sbjct: 426  RSKDASPINRWSPTRRRSRSPIRRR-SRSPLRRSRS-PRRRSRSPRR 470



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 95/408 (23%), Positives = 159/408 (38%), Gaps = 141/408 (34%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKS 1836
            E  S     E +D      + + + +  ++++++K  + KK+    RS+ K+ K S  + 
Sbjct: 5    ETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEED 64

Query: 1837 RKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRR------------------------- 1871
            + +  + + + +K   K     S     S ++R +                         
Sbjct: 65   KDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNEL 124

Query: 1872 ---------------------------RSSRSRSKSRGRRSVSKEK-----RKRSPKHRS 1899
                                         +R+ ++S  R S +K K      K + K RS
Sbjct: 125  MEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKKRS 184

Query: 1900 KSR--ERKRKRSSSRDNR--------KTVRA------RSRTPSRRSRSHTPSRRRRSRSV 1943
            KSR  ER R RS  + ++        KT R+      +S++PS+RS+S   +R+ +S ++
Sbjct: 185  KSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTL 244

Query: 1944 GRRRSFSISPSR---------------------------RSRTPSRRSRTP--------S 1968
             RR    I  +R                           RSR   ++SR+P         
Sbjct: 245  RRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKD 304

Query: 1969 RRSRTPSRRS-------------------------RTPSRR-SRTPSRRSRTPSRRRRSR 2002
            RRSR+  R+S                         R+PSRR  R+P RRS +P  R +SR
Sbjct: 305  RRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSR 364

Query: 2003 SVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSER-GRSPKR 2049
               R RS  ++  R ++S++P R   + SP RR +SRS ER  R P+R
Sbjct: 365  ---RSRSPLLNDRRSKQSKSPSR---TLSPGRRAKSRSLERKRREPER 406



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 28/230 (12%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            + R + SP+++    + S+S S           +        ++  R + E E++R SS 
Sbjct: 362  KSRRSRSPLLNDRRSKQSKSPSRT---------LSPGRRAKSRSLERKRREPERRRLSSP 412

Query: 1823 RSR------SKRSKSSEHKSRKRTSESRSRAR---KRSSKSKSHRSQTRSRSRSRRRRRS 1873
            R+R      S+R +S +     R S +R R+R   +R S+S   RS++  R RSR  RR 
Sbjct: 413  RTRPRDDILSRRERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRS-PRRRSRSPRRR 471

Query: 1874 SRS-RSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARS-------RTP 1925
             R  RS+SR RR  S+ +  R  + RSK +E K K S S   +    + S          
Sbjct: 472  DRGRRSRSRLRRR-SRSRGGRRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVE 530

Query: 1926 SRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPS 1975
                 +    RR + +++ ++  +    S  S      S   S R+R+PS
Sbjct: 531  EEDEEALIEQRRIQRQAIVQKYKYLAEDSNMSVPSEPSSPQSSTRTRSPS 580



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 66/334 (19%), Positives = 136/334 (40%), Gaps = 32/334 (9%)

Query: 1803 SKKNKNRDKGEKEKKRDSSLRSRSKRSKS---SEHKSRKRTSES-RSRARKRSSKSKSHR 1858
            S+K+ N + GE  + +  +  SR K+ K    S+HK  K +SE  + +  K   K K H+
Sbjct: 20   SEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHK 79

Query: 1859 -------SQTRSRSRSRRRRRSS----RSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRK 1907
                   S     S ++R +           K R       +      K +S      + 
Sbjct: 80   RKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQG 139

Query: 1908 RSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTP 1967
              S  +    +  ++R    RS + + S + +   V  +    I+  +RS++ S+     
Sbjct: 140  YESGSEEEGEIHEKARN-GNRSSTRSSSTKGKLELVDNK----ITTKKRSKSRSKE---- 190

Query: 1968 SRRSRTPSRRSRTPSRRSRTPSRRSRTPSR-RRRSRSVVRRRSFSISPVRLRRSRTPLRR 2026
              R+R  S + ++         + +R+ S+ R++S+S  +R   S S  + R+S++P  R
Sbjct: 191  --RTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKR---SKSQDQARKSKSPTLR 245

Query: 2027 RFSRSPIRRKRSRSSERGR--SPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPA 2084
            R S+  I + RS + ++ +     +  D  K+ ++  +++      +++ V L    K  
Sbjct: 246  RRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDR 305

Query: 2085 PPPTIEEKVAKKSGGATIEELTEKCKQIAQSKED 2118
               + E K  +       + +    K  +  KE+
Sbjct: 306  RSRSKERKSKRSETDKEKKPIKSPSKDASSGKEN 339



 Score = 38.9 bits (89), Expect = 0.059
 Identities = 20/67 (29%), Positives = 35/67 (52%), Gaps = 4/67 (5%)

Query: 77  LRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEES 136
           LR +P++++ + +    S+  +  +    +   KH +HK KKK K + K KK+K   EE 
Sbjct: 9   LREQPEMEDANSEK---SINEENGEVSEDQSQNKHSRHK-KKKHKHRSKHKKHKHSSEED 64

Query: 137 ESKTKSH 143
           + K   H
Sbjct: 65  KDKKHKH 71



 Score = 32.3 bits (72), Expect = 5.5
 Identities = 14/42 (33%), Positives = 23/42 (54%)

Query: 106 KKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGN 147
           KK K   KHK  K   +++K+KK+K + +  + K K   D +
Sbjct: 46  KKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDAS 87


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score =  122 bits (305), Expect = 5e-27
 Identities = 318/1498 (21%), Positives = 536/1498 (35%), Gaps = 196/1498 (13%)

Query: 94   SVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESD 153
            S +T P   +P   +       N       + + +     E S S T       I   S+
Sbjct: 2040 SERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSE 2099

Query: 154  SFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHI------LETLKP 207
                  S P +     P  +   S  + +P     P + S EVS   I      ++T   
Sbjct: 2100 GSPLLTSIPLSTT---PVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTY 2156

Query: 208  ATKTAELSV--VSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVT 265
            + +   L+   VST+V++  +  +++  P  + T + +S  A   PTT+    +S P  T
Sbjct: 2157 SDRRTPLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSE--GTSMPTST 2214

Query: 266  MSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTT 325
             S            E ++P  S  +   P V           V + TP     E ++S T
Sbjct: 2215 PS------------EGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPT 2262

Query: 326  MDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPG 385
                E ++I    L E    + S     ++    E+  L  T        + ++    P 
Sbjct: 2263 T--AEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASSPP 2320

Query: 386  PPA--TSMP-ELQGPPVTPVLELPGPSA-------TPVPELPGPLSTPVPELP--GPPAT 433
            P A  TSMP        TP+  +P  +        + +   P   STPV      G   T
Sbjct: 2321 PTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPT 2380

Query: 434  AVPELPGPSVTPVPQLSQELPGLPAPSMGL---------EPPQEVPEPPVMAQELPGLPL 484
               +   P+ T   + S  L  +P  +M +           P +   P   + E    P 
Sbjct: 2381 TADDTSMPTST-YSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEASSSPT 2439

Query: 485  VTAAVELPEQPAVTVAMELTEQPVTTTEL--EQPVGMTTVEHPGHPEVTTATGLLGQPEA 542
                  +P  P       L   PV+TT +   +   ++T        +TT+T     P  
Sbjct: 2440 TAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTSTPMTTSTEASSSPTT 2499

Query: 543  TMVLELP------------GQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVA 590
               + +P              PV+TT +  P   +++  P     P  T + E+S    +
Sbjct: 2500 AEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTTPVDSNSPVVT-STEISSSATS 2558

Query: 591  TGALELPGPLMAAGALEFSGQS------GAAGALELLGQPLATGV-----LELPGQPGAP 639
                 +P    + G+              ++ A  L   P+ T +      E    P   
Sbjct: 2559 AEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLSTTPVDTSIPVTTSTETSSSPTTA 2618

Query: 640  ELPGQPVATVA-LEISVQSVVTT---------SELSTMTVSQSLEVPSTTALESYNTVAQ 689
            +    P++T + +  S+ S++ +         S LST  V     V ++T   S  T A+
Sbjct: 2619 KDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAE 2678

Query: 690  --ELPTTLVGE-----TSVTVGVDPLMAPESHILASNTMETHILASNTMDSQMLASNTMD 742
               +PT+  GE     T++ V    L   E+  L++  ++T    + + ++    +    
Sbjct: 2679 GSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEG 2738

Query: 743  SQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMD 802
            + M  S   D     +S + S +   SS  S +  T+   S  + TST  S    T+ + 
Sbjct: 2739 TSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTSTEASSSPTTAEVT 2798

Query: 803  SQMLATSSMDSQMLAT--------SSMDSQMLATSSMD-SQMLATSTMDSQMLATSTMDS 853
            S   +T S  S  L +        +S ++  L+T+ +D S  + TST  S    T+    
Sbjct: 2799 SMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIV 2858

Query: 854  QMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDP 913
              ++T+S  S +L S  + +  +AS   +A  L++  +D  +  +++ +    GS SP  
Sbjct: 2859 VPISTASEGSTLLTSIPVSTTPVASS--EASTLSTTPVDTSIPVTTSTE----GSSSPTT 2912

Query: 914  YRLAQDPYRLAQDPYR-----LGHDPYRLGHDAYRLGQDPYRLGHDPYRLTPDPYRMSPR 968
                  P     +        L       G +A  L   P     D           S  
Sbjct: 2913 AEGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPV----DTRTPVTTSAEASSS 2968

Query: 969  PYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAA--ERSMMSSYERSMMSYERSMMS 1026
            P      S  I+    R  P   M  S   +  S A+   R+   +      S E S   
Sbjct: 2969 PTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSP 3028

Query: 1027 PMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSM 1086
              AE + +     S  S     + S     + ++  E S +S       SP+   + +S 
Sbjct: 3029 TTAEGTGIPI---STPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVS- 3084

Query: 1087 GADRSMMSSYSAADRSMM--SSYSAADRSM----MSSYTADRSMMSMAADSYTDSYTD-- 1138
                   SS + A+ + M  S+YS     +    +S+     S +S  + +  D+ T   
Sbjct: 3085 -------SSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVT 3137

Query: 1139 TYTEAYMVPPLPPEEPPTMPPLPPEE--------PPMTPPLPPEEPPEGPALPTEQS--- 1187
            T TEA+  P     E  +MP   P E        P  T  +   E     A P + S   
Sbjct: 3138 TSTEAHSSPTT--SEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPV 3195

Query: 1188 --------ALTAENTW-PTEVPSSPSEESVSQP--EPPVSQSEISEPSAVPTDYSVSASD 1236
                    + TAE T  PT  PS       S P    PV+ SE S  S  P D     S+
Sbjct: 3196 TTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVD-----SN 3250

Query: 1237 PSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCM-VSETPAMSAEP 1295
              +  S  A + P P  E  S  T TP E +            P+T M VS T   S+E 
Sbjct: 3251 TPLTTSTEASSSP-PTAEGTSMPTSTPSEGST-----------PLTSMPVSTTTVASSET 3298

Query: 1296 TVLASEPPVMSETAETFDSMRASGHVASEVS-TSLLVPAVTTPVLAESILEPPAMAAPES 1354
            + L++ P   S    T+    +S  +A   S  +      +TP+   S    P +++   
Sbjct: 3299 STLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSS--- 3355

Query: 1355 SAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALE 1414
                  E+S ++     T T + +ST   L P+       P  +  +  T   P+ S   
Sbjct: 3356 ------EASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTT---PLASMPV 3406

Query: 1415 PSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPM 1472
             + PV+   V+ L  + + S   V    +T T +  + T++E T +  +  +  STP+
Sbjct: 3407 STTPVVSSEVNTLSTTPVDSNTLV----TTSTEASSSPTIAEGTSLPTSTTSEGSTPL 3460



 Score =  121 bits (304), Expect = 7e-27
 Identities = 359/1725 (20%), Positives = 618/1725 (35%), Gaps = 206/1725 (11%)

Query: 170  PTRAFGPSETNESPAVVLEPPVVSMEVS-------EPHILETLKPATKTAELSVVSTSVI 222
            PT A G S    +P     PP+ S+ VS       E + L T    T+T   +    S  
Sbjct: 1908 PTTADGSSMPTSTPREG-RPPLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQAS-- 1964

Query: 223  SEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVEST 282
            S  +      MP P+ ++      + P+ TT +V   +  + T  V+    +   +  S+
Sbjct: 1965 SSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSS 2024

Query: 283  SPEPS---KIMLVEP-----PVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAI 334
            SP  +    I    P     P+A  +  S TLVVSSE  T        STT   P  S  
Sbjct: 2025 SPTTAGGTSIQTSTPSERTTPLAG-MPVSTTLVVSSEGNT-------LSTT---PVDSKT 2073

Query: 335  EALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPPATSMPEL 394
            +     E      +E +  +++ P E    P  T++ L  + VAS      P A+++   
Sbjct: 2074 QVTNSTEASSSATAEGSSMTISAPSE--GSPLLTSIPLSTTPVAS------PEASTLSTT 2125

Query: 395  QGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVP---------------ELP 439
                 +PV+     S++P+P     + T        P T++P                 P
Sbjct: 2126 PVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTP 2185

Query: 440  GPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEP---PVMAQELPGLPLVTA------AVE 490
              + TPV   S E    P  S G   P   P     P  +  +  +P+VT+      A  
Sbjct: 2186 VDTSTPVTN-STEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATP 2244

Query: 491  LPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELP- 549
            +     VT + E T  P T      P    +        +  +  L+   E + +   P 
Sbjct: 2245 VDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPV 2304

Query: 550  -GQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVAT--------GALELPGPL 600
                  TT+ E    P       +P   S+     L+  PV+T          L      
Sbjct: 2305 DSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPAD 2364

Query: 601  MAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVVT 660
             +     +S    +    +    P +T         G+  L   PV+T+ +  S  S  +
Sbjct: 2365 TSTPVTTYSQAGSSPTTADDTSMPTSTY------SEGSTPLTSVPVSTMPVVSSEASTHS 2418

Query: 661  TSELSTMTVSQSLEVPSTTALESYNTVAQ--ELPTTLVGE-----TSVTVGVDPLMAPES 713
            T+ + T T      V ++T   S  T A+   +PT+   E      S+ V   P+++ E+
Sbjct: 2419 TTPVDTST-----PVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEA 2473

Query: 714  HILASNTMETHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASS---------TMDSQ 764
              L++  ++T    + + ++    +   D  +  S   +   L +S         + ++ 
Sbjct: 2474 GTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEAS 2533

Query: 765  MLATSSMDSQMLATSSMDSQMLATSTMDSQM-LATSSMDSQMLATSSMDSQMLATSSMDS 823
             L+T+ +DS     +S +    ATS   + M  +T S  S  L +  + ++ LA+S  ++
Sbjct: 2534 TLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASS--EA 2591

Query: 824  QMLATSSMDSQMLATSTMDSQMLATSTMDSQM-LATSSMDSQMLASGTMDSQMLASGTMD 882
              L+T+ +D+ +  T++ ++    T+  D+ M ++T S  S  L S  + +  +AS   +
Sbjct: 2592 STLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASS--E 2649

Query: 883  AQMLASGTMDAQMLASSTQDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGH-DA 941
            A  L++  +D + L +++  ++   + +         P   +     +      L + +A
Sbjct: 2650 ASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEA 2709

Query: 942  YRLGQDPYRLGHDPYRLTPDPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMM 1001
              L   P     D           S  P      S RI+       P   +L S   +  
Sbjct: 2710 STLSTTPV----DTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVAS 2765

Query: 1002 SYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSA 1061
            S A+  S  ++ + S+     +  S     + +++   S  S     + S     + +++
Sbjct: 2766 SEASTVST-TAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVAS 2824

Query: 1062 YERSMMSAYERSMMSPMADRSMMSMG---ADRSMMSSYSAADRSMM--------SSYSAA 1110
             E   +S       +P+   +  S     A+  ++   +A++ S +        +  +++
Sbjct: 2825 SEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASS 2884

Query: 1111 DRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPT---------MPPLP 1161
            + S +S+   D S+      S   S + T  E   +P   P E  T         +P   
Sbjct: 2885 EASTLSTTPVDTSIP--VTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAG 2942

Query: 1162 PEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVP-SSPSEE-----SVSQPEPPV 1215
             E   ++        P   +     S  TAE T    +P S+P E      S+S    PV
Sbjct: 2943 SEASTLSTTPVDTRTPVTTSAEASSSPTTAEGT---SMPISTPGERRTPLTSMSVSTMPV 2999

Query: 1216 SQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEV 1275
            + SE S  S  P D S   +  +   S          P    S   TP+ S  V+     
Sbjct: 3000 ASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVA 3059

Query: 1276 VPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLL-VPAV 1334
            +PE      +S TP  S  P V ++E    S T     SM  S +  SE ST L  VP  
Sbjct: 3060 IPE---ASTLSTTPVDSNSPVVTSTEVS-SSPTPAEGTSMPISTY--SEGSTPLTGVPVS 3113

Query: 1335 TTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEP 1394
            TTPV               SSA++ L ++ V      T +    S+ T  E + +    P
Sbjct: 3114 TTPV--------------TSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTP 3159

Query: 1395 PVVAEP-DYVTIPVPVVSALEPSVPVLEPA-VSVLQPSMIVSEPSVSVQESTVTVSEPA- 1451
               + P  Y+ +   +V + E S     P   S    +   +  S + + +++  S P+ 
Sbjct: 3160 SEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSE 3219

Query: 1452 -VTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIALHSG 1510
             +T      V  T VA     ++  + + S+  +     +S     A    M       G
Sbjct: 3220 GMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEG 3279

Query: 1511 EEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTS 1570
              P     +      S     +     +          T   A +SP   I +   +PTS
Sbjct: 3280 STPLTSMPVSTTTVASSETSTLSTTPAD----TSTPVTTYSQASSSP--PIADGTSMPTS 3333

Query: 1571 ETKQRTV------LDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVN 1624
               + +         T P VS      TLS+T      P  T T   +  TTA   S   
Sbjct: 3334 TYSEGSTPLTNMSFSTTPVVS--SEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTS--- 3388

Query: 1625 KYDVDLSLTTQDTE--HDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEP 1682
               +  S  ++ T     M +ST+P   SE +     P          +N LV+  TE  
Sbjct: 3389 ---IPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPV--------DSNTLVTTSTE-- 3435

Query: 1683 LPVKESDQTLAALLSPKESSGGEKEVPPP--PKETLPDSGFSANIEDINEADLVRPLLPK 1740
                 S  T+A   S   S+  E   P    P  T P +   A+       D   P+   
Sbjct: 3436 ---ASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTS 3492

Query: 1741 DMERLTSLRAGIEG-PLLASDVGRDRSAASPVVSSMPERASESSS 1784
                 +   A +   P   +  G       P VS+ P  +SE+S+
Sbjct: 3493 SPTNSSPTTAEVTSMPTSTAGEGSTPLTNMP-VSTTPVASSEAST 3536



 Score =  118 bits (296), Expect = 6e-26
 Identities = 341/1586 (21%), Positives = 587/1586 (37%), Gaps = 195/1586 (12%)

Query: 163  SAVALELPTRAFGPSETNESPAVVLEP---------PVVSMEVSEPHI--LETLKPATKT 211
            S  A   PT + G S  N +P+    P         PV+S E S      ++T  P T  
Sbjct: 1724 STEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVT-- 1781

Query: 212  AELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQ 271
                  ST   S  +      +P  ++++ +    + PV  T +    +  + T  V+  
Sbjct: 1782 -----TSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSN 1836

Query: 272  MKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSE--TLVVSSETPTEVYPEPSTSTTMDFP 329
               V  +  S+SP P+     E        PSE  T + S    T       T+T    P
Sbjct: 1837 SPVVTSTAVSSSPTPA-----EGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTP 1891

Query: 330  ESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPPAT 389
              ++        Q    P+    SSM         P  T++ +  ++VAS+ E+    +T
Sbjct: 1892 AVTSTPVTTY-AQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASS-EI-NTLST 1948

Query: 390  SMPELQGPPVTPVLELPGPSATPVPELPGPL----STPVPELPGPPATAV-PELPGPSVT 444
            ++ + + P  T       P+      +P P     STP+  +P      V  E    S T
Sbjct: 1949 TLADTRTPVTTYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTT 2008

Query: 445  PV---PQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAV-TVA 500
            PV      +    G  +P+       +   P      L G+P+ T  V   E   + T  
Sbjct: 2009 PVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTP 2068

Query: 501  MELTEQPVTTTELEQPV----GMTTVEHP--GHPEVTT---ATGLLGQPEATMVLELP-- 549
            ++   Q   +TE            T+  P  G P +T+   +T  +  PEA+ +   P  
Sbjct: 2069 VDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVD 2128

Query: 550  -GQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPLMAAGALEF 608
               PV T+  E+   P  T    +     + R   L+  PV+T  +     +        
Sbjct: 2129 SNSPVITST-EVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVST-TVVASSAISTLSTTPV 2186

Query: 609  SGQSGAAGALELLGQPLATGVLELP---GQPGAPELPGQPVATVALEISVQSVVTTSELS 665
               +    + E    P  +    +P      G+      PV+T+         V TSE S
Sbjct: 2187 DTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMP--------VVTSEAS 2238

Query: 666  TMT---VSQSLEVPSTTALESYNTVAQ--ELPTTLVGETSVTVGVDPLMA-PESHILASN 719
            T++   V  S  V ++T   S  T A+   +PT+ + E     G  PL + P SH L +N
Sbjct: 2239 TLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSE-----GTTPLTSIPVSHTLVAN 2293

Query: 720  ----TMETHILASNTMDSQMLASN----TMDSQMLASNTMDSQMLASSTMDSQMLATSSM 771
                T+ T  + SNT  +    ++    T +   + ++T        + M       +S 
Sbjct: 2294 SEVSTLSTTPVDSNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASF 2353

Query: 772  DSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSM 831
            ++  L+T+  D+    T+   +    T++ D+ M  ++  +     TS   S M   SS 
Sbjct: 2354 ETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSE 2413

Query: 832  DSQMLATSTMDSQMLATSTMDSQMLAT---SSMDSQMLASGTMDSQMLASGTMDAQMLAS 888
             S    T    S  + TST  S    T   +S+ +   + GT     +   T       +
Sbjct: 2414 ASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEA 2473

Query: 889  GTMDAQMLASST-QDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQD 947
            GT+    + +ST   ++   S SP        P   A +   L                 
Sbjct: 2474 GTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTL----------------- 2516

Query: 948  PYRLGHDPYRLTPDPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAER 1007
                      LT  P   +P     +P +  ++  P   +  P++ ++  S   + A   
Sbjct: 2517 ----------LTSIPVSTTP---VASPEASTLSTTPVD-SNSPVVTSTEISSSATSAEGT 2562

Query: 1008 SMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMM 1067
            SM +S      +  RSM  P++ + + S+ E S +S        P+   +  S+   S  
Sbjct: 2563 SMPTSTYSEGSTPLRSM--PVSTKPLASS-EASTLSTTPVDTSIPVTTSTETSS---SPT 2616

Query: 1068 SAYERSMMSPMADRSMMSMGADRSMMSS--YSAADRSMMSSYSAADRSMMSSYTADRSMM 1125
            +A + SM  P++  S +S      ++S+   ++++ S +S+     R+++++ T   S  
Sbjct: 2617 TAKDTSM--PISTPSEVSTSLTSILVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSP 2674

Query: 1126 SMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTE 1185
            + A      S   T T      PL      T      E   ++        P   +    
Sbjct: 2675 TTA----EGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEAS 2730

Query: 1186 QSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAA 1245
             S  TAE T  +   S+PS+ S   P   +  S +   S+  +  S +A D S+ V+ + 
Sbjct: 2731 SSPTTAEGT--SMRISTPSDGST--PLTSILVSTLPVASSEASTVSTTAVDTSIPVTTST 2786

Query: 1246 VTVPEP-PPEPESSITLTPVESAVVAEEHEVVPERPVTCM-VSETPAMSAEPTVLASEP- 1302
                 P   E  S  T TP E++            P+T M V+ TP  S+E   L++ P 
Sbjct: 2787 EASSSPTTAEVTSMPTSTPSETST-----------PLTSMPVNHTPVASSEAGTLSTTPV 2835

Query: 1303 ----PVMSETAETFDSMRASGHV-----ASEVSTSLL-VPAVTTPVLAESILEPPAMAAP 1352
                PV + T  +     A G V     ASE ST L  +P  TTPV +           P
Sbjct: 2836 DTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSE--ASTLSTTP 2893

Query: 1353 ESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSA 1412
              +++ V  S+      SS+ T  E +++ +  PS V+ P   ++      T+PV    A
Sbjct: 2894 VDTSIPVTTSTE----GSSSPTTAEGTSMPISTPSEVSTPLTSILVS----TVPVAGSEA 2945

Query: 1413 -------LEPSVPVLEPAVSVLQP------SMIVSEPSV-SVQESTVTVSEPAVTVSEQT 1458
                   ++   PV   A +   P      SM +S P       ++++VS   V  SE +
Sbjct: 2946 STLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEAS 3005

Query: 1459 QVIPTEVAIESTPMILESSIMSSHVM---KGINLSSGDQNLAPEIGMQEIALHSGEEPHA 1515
             +  T  A  STP+   +   SS       GI +S+  +   P   +  ++      P A
Sbjct: 3006 TLSRTP-ADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSI-PVSTTPVAIPEA 3063

Query: 1516 EEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVC--AAGTSPVGEIGEEKILPTS--- 1570
               L     +S   +     +++     E     +   + G++P+  +       TS   
Sbjct: 3064 ST-LSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVTSSAI 3122

Query: 1571 ETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGT--SKGIEFTTASTLSLVNKYDV 1628
             T   T +DT   V+ +    +  +T      P +T +  S  + +   ST+ +V+  D 
Sbjct: 3123 STLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDS 3182

Query: 1629 DLSLTTQDTEHDMVISTSPSGGSEAD 1654
             LS T  DT   +  ST  +  + A+
Sbjct: 3183 TLSATPVDTSTPVTTSTEATSSTTAE 3208



 Score =  118 bits (295), Expect = 8e-26
 Identities = 387/1844 (20%), Positives = 645/1844 (34%), Gaps = 256/1844 (13%)

Query: 134  EESESKTKSHDDGNIDLES---DSFLKFDSEPSAVA---LELPTRAFGPSETNESPAVVL 187
            E +   T ++ +G+  L S   ++ L   SE S ++   ++  T     +E + SP    
Sbjct: 674  EGTSMPTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTA- 732

Query: 188  EPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAA 247
                 SM  S P   E   P T       VS ++++     +++  P  + T I  S  A
Sbjct: 733  --DGASMPTSTPS--EGSTPLTSMP----VSKTLLTSSEASTLSTTPLDTSTHITTSTEA 784

Query: 248  APVPTTTLVLKSSEPVVTMSVEYQM-KSVLKSVES-TSPEPSKIMLV----EPPVAKVLE 301
            +  PTTT    +S P+ T S    +  S+  S+   TSPE S +         PV    E
Sbjct: 785  SCSPTTTE--GTSMPISTPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTE 842

Query: 302  PSETLVVSSET--PTEVYPEPSTSTTMDFPESSAIEALR----LPEQPVDVPSEIADSSM 355
             S +   +  T  PT  Y E  T  T   P S+ + A      L   PVD  + + +S+ 
Sbjct: 843  VSSSPTPAEGTSMPTSTYSEGRTPLT-SMPVSTTLVATSAISTLSTTPVDTSTPVTNSTE 901

Query: 356  TRPQELPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPE 415
             R    P   + T++        S       P TSMP+   P V+   E    SATPV +
Sbjct: 902  ARSS--PTTSEGTSMPTSTPGEGST------PLTSMPDSTTPVVSS--EARTLSATPV-D 950

Query: 416  LPGPLSTPVPELPGPPA---TAVP-ELPGPSVTPVPQ--LSQELPGLPAPSMGLEPPQEV 469
               P++T       P     T++P   P    TP+    +S  L      S     P + 
Sbjct: 951  TSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDS 1010

Query: 470  PEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPE 529
              P   + E    P       +P       +  LT  PV+TT +      T    P    
Sbjct: 1011 NTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTS 1070

Query: 530  VTTATGLLGQPEATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPV 589
                T       +T   +    P +T +    G   +T VP    L  ++ A  LS  PV
Sbjct: 1071 TPVTTYSQASSSSTTA-DGTSMPTSTYS---EGSTPLTSVPVSTRLVVSSEASTLSTTPV 1126

Query: 590  ATGALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATV 649
             T        +    + E S     A           T +   P   G   L   PV+T 
Sbjct: 1127 DTS-------IPVTTSTEASSSPTTAEG---------TSIPTSPPSEGTTPLASMPVSTT 1170

Query: 650  ALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQ--ELPTTLVGE-----TSVT 702
             +   V S   T  LST  V    +V ++T   S    A+   +PT+  GE     TS+ 
Sbjct: 1171 LV---VSSEANT--LSTTPVDSKTQVATSTEASSPPPTAEVTSMPTSTPGERSTPLTSMP 1225

Query: 703  VGVDPLMAPESHILASNTMETHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMD 762
            V   P+ + E+  L+++ ++T    + + ++    +    + +  S T +   L +S   
Sbjct: 1226 VRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIPV 1285

Query: 763  SQMLATSSMDSQMLAT---------SSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDS 813
            S  L TS   S +L T         +S +     T    + M  ++  + +   TS   +
Sbjct: 1286 STTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVN 1345

Query: 814  QMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLATSSMDSQMLASGTMDS 873
              L  SS  S +  T   +S  + TST       TS   S   +  S  +  L S  + +
Sbjct: 1346 TTLVASSAISILSTTPVDNSTPVTTSTEACSSPTTSEGTSMPNSNPSEGTTPLTSIPVST 1405

Query: 874  QMLASG---TMDAQMLAS---GTMDAQMLAS-STQDSAMLGSKSPDPYRLAQDPYRLAQD 926
              + S    T+ A  + +   GT  A+  +S +T +   + + +P   +       ++  
Sbjct: 1406 TPVVSSEASTLSATPVDTSTPGTTSAEATSSPTTAEGISIPTSTPSEGKTPLKSIPVSNT 1465

Query: 927  PYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTPDPYRMSPRPYR------IAPRSYRIA 980
            P            +A  L   P    + P  +T      SP P          P     A
Sbjct: 1466 PVA--------NSEASTLSTTPVD-SNSPV-VTSTAVSSSPTPAEGTSIAISTPSEGSTA 1515

Query: 981  PRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERS 1040
                 ++   +  +   S+  + A   + +++Y ++  S   +  + M + S  S     
Sbjct: 1516 LTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQASSSPTTADGTSM-QTSTYSEGSTP 1574

Query: 1041 MMSAYERSMMSPMAERSMMSAY---ERSMMSAYERSMMSPMADRSMMSMG--ADRSMMSS 1095
            + S    +M+   +E + +S      ++ ++A   +  S  A+ S M++   ++ S + +
Sbjct: 1575 LTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLT 1634

Query: 1096 YSAADRSMMSSYSAADRSM--------------MSSYTADRSMMSMAADSYTDSYTDTYT 1141
                  + ++S  A+  S               +SS        SM   +YT+  T   +
Sbjct: 1635 SIPVSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPTPAEGTSMPTSTYTEGRTPLTS 1694

Query: 1142 EAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPS 1201
                  P+      T+   P +        P     E  + PT     +  N+ P+E  +
Sbjct: 1695 ITVRTTPVASSAISTLSTTPVDNST-----PVTTSTEARSSPTTSEGTSMPNSTPSEGTT 1749

Query: 1202 SPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPP-----EPE 1256
              +   VS    PV  SE S  SA P D S   +  +   S          P     E  
Sbjct: 1750 PLTSIPVSTT--PVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGM 1807

Query: 1257 SSITLTPVESAVVA-EEHEVVPERPV--------TCMVSETPAMSAEPTVLASEPPVMSE 1307
            + +T TPV   +VA  E   +   PV        +  VS +P   AE T +A+  P    
Sbjct: 1808 TPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPT-PAEGTSIATSTPSEGS 1866

Query: 1308 TAETFDSMRASGHVASEVSTSLLVPAVT-TPVLAESILEPPAMAAPESSAMAVLESSAVT 1366
            TA T   +  +   +SE +T    PAVT TPV   + +      A  SS           
Sbjct: 1867 TALTSIPVSTTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREGRP 1926

Query: 1367 VLESSTV--TVLESSTVTVLEPSVVTVPEPPVV--------AEPDYVTIPVPVVSALEPS 1416
             L S  V  T + SS +  L  ++     P              D  ++P P  S  E S
Sbjct: 1927 PLTSIPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGTSMPTPAYS--EGS 1984

Query: 1417 VPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIE---STPMI 1473
             P+    +S    +++VS  + ++  + V  S PA T +E +    T        STP  
Sbjct: 1985 TPLTSMPLST---TLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQTSTPSE 2041

Query: 1474 LESSIMSSHVMKGINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFY--------- 1524
              + +    V   + +SS    L+      +  + +  E  +    +G            
Sbjct: 2042 RTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGS 2101

Query: 1525 ----------------ESEHGINIDLNINNHLI-AKEMEHNTVCAAGTSPVGEIGEEKIL 1567
                            E+       ++ N+ +I + E+  + +   GTS       ++  
Sbjct: 2102 PLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPIPTEGTSMQTSTYSDRRT 2161

Query: 1568 PTS--------------ETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIE 1613
            P +               T   T +DT   V+ +    +  +T      P +T +     
Sbjct: 2162 PLTSMPVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGSTP 2221

Query: 1614 FTT--ASTLSLVNKYDVDLSLTTQDTEHDMVIST----SPSGGSEADI------EGPLPA 1661
            FT+   ST+ +V      LS T  DT   +  ST    SP+      I      EG  P 
Sbjct: 2222 FTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPL 2281

Query: 1662 KDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKE--TLPDS 1719
              I    P ++ LV+      L     D       S + SS      PPP  E  ++P S
Sbjct: 2282 TSI----PVSHTLVANSEVSTLSTTPVDSNTPFTTSTEASS------PPPTAEGTSMPTS 2331

Query: 1720 GFSANIEDINEADLVRPLL-----------PKDMER-LTSLRAGIEGPLLASDVGRDRSA 1767
              S     +    +   ++           P D    +T+       P  A D     S 
Sbjct: 2332 TSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTTYSQAGSSPTTADDTSMPTST 2391

Query: 1768 --------ASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKS 1803
                     S  VS+MP  +SE+S+      +    V  + E S
Sbjct: 2392 YSEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTTSTEAS 2435



 Score =  112 bits (280), Expect = 4e-24
 Identities = 309/1453 (21%), Positives = 508/1453 (34%), Gaps = 199/1453 (13%)

Query: 163  SAVALELPTRAFGPSETNESPA---------VVLEPPVVSMEVS--EPHILETLKPATK- 210
            SA A   PT A G S    +P+         +V   PV S E S      ++T  P T  
Sbjct: 2726 SAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAVDTSIPVTTS 2785

Query: 211  --------TAELSVVSTSVISEQSEQ--SVAVMPEPSMTKILDSFAAAPV----PTTTLV 256
                    TAE++ + TS  SE S    S+ V   P  +    + +  PV    P TT  
Sbjct: 2786 TEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTST 2845

Query: 257  LKSSEP------VVTMSVEYQMKSVLKSVE-STSPEPSK---IMLVEP-----PVAKVLE 301
              SS P      VV +S   +  ++L S+  ST+P  S     +   P     PV    E
Sbjct: 2846 KASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTE 2905

Query: 302  PSETLVVSS------ETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADS-- 353
             S +   +        TP+EV   P TS  +     +  EA  L   PVD  + +  S  
Sbjct: 2906 GSSSPTTAEGTSMPISTPSEV-STPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAE 2964

Query: 354  --SMTRPQELPELPKTTALELQE---SSVASAMELPGPPATSMPELQGPPVTPVLELPGP 408
              S     E   +P +T  E +    S   S M +    A+++        TPV      
Sbjct: 2965 ASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEA 3024

Query: 409  SATPVP--------ELPGPLSTPVPELP-GPPATAVPELPGPSVTPVPQ-----LSQELP 454
            S++P            P   STP+  +P      A+PE    S TPV        S E+ 
Sbjct: 3025 SSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVS 3084

Query: 455  GLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELE 514
              P P+ G   P  +      +  L G+P+ T  V       ++     T  PVTT+  E
Sbjct: 3085 SSPTPAEGTSMP--ISTYSEGSTPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTST-E 3141

Query: 515  QPVGMTTVEHPGHPEVTTATG---LLGQPEATMVL------ELPGQPV-----ATTALEL 560
                 TT E    P  T + G   L   P +TM++       L   PV      TT+ E 
Sbjct: 3142 AHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEA 3201

Query: 561  PGQPSVTGVPELPGLPSA----TRALELSGQPVATGALELPGPLMAAGALEFSGQSGAAG 616
                +  G       PS       ++ +S  PVA+    +            +  + A+ 
Sbjct: 3202 TSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASS 3261

Query: 617  ALELLGQPLATGVLELPGQP--GAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLE 674
            +      P A G       P  G+  L   PV+T  +  S      TS LST     S  
Sbjct: 3262 S-----PPTAEGTSMPTSTPSEGSTPLTSMPVSTTTVASS-----ETSTLSTTPADTSTP 3311

Query: 675  VPSTTALESYNTVAQ--ELPTTLVGE-----TSVTVGVDPLMAPESHILASNTMETHILA 727
            V + +   S   +A    +PT+   E     T+++    P+++ E+  L++  ++T    
Sbjct: 3312 VTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPV 3371

Query: 728  SNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDSQMLATSSMDSQMLA 787
            + + ++            L+  T +   + +S+        +SM        S +   L+
Sbjct: 3372 TTSTEAS-----------LSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLS 3420

Query: 788  TSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLA 847
            T+ +DS  L T+S ++    T + +   L TS+        S M       ++ ++  L+
Sbjct: 3421 TTPVDSNTLVTTSTEASSSPTIA-EGTSLPTSTTSEGSTPLSIMPLSTTPVASSEASTLS 3479

Query: 848  TSTMD-SQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAML 906
            T+ +D S  + TSS  +    +  + S   ++    +  L +  +    +ASS  +++ L
Sbjct: 3480 TTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASS--EASTL 3537

Query: 907  GSKSPDPYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPY--------RL 958
             +   D         + +  P  L     R+   +         L    Y          
Sbjct: 3538 STTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPS 3597

Query: 959  TPDPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSY--AAERSMMSSYERS 1016
            TP   R +P        S    P P  +   P+   S  S  ++    +  S+  S   +
Sbjct: 3598 TPSVDRSTPVTTSTQSNS---TPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTISEAGT 3654

Query: 1017 MMSYERSMMSPMAERSMMSAY----ERSMMSAYERSMMSPMAERSMMSAYERSMMSAYER 1072
              +      +P+   + +S+     E + M  +  S  S       +S    + +++ E 
Sbjct: 3655 ASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVST---TRVTSSEG 3711

Query: 1073 SMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMM-SSYTADRSMMSMAADS 1131
            S +S  +  +   +      +SS +  D + MS     + S + ++     + ++   +S
Sbjct: 3712 STLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGTTILVSTTPVTRFPES 3771

Query: 1132 YTDSYTDTYTEAYMV-------PPLPPEEPPTMPPLPPEE------PPMTPPLPPEEPPE 1178
             T S    YT   M         P   E   TMP     E        +  P+    P E
Sbjct: 3772 STPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSE 3831

Query: 1179 GPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPS 1238
               L T       + + P    +     S+      +  S  SE S   T   VS + P+
Sbjct: 3832 ASTLSTP----PGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTLLVSTTLPT 3887

Query: 1239 VLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSE---TPAMSAEP 1295
               S    ++   PP  ++S T TP      + +    P  PV   +S    T   +   
Sbjct: 3888 ---SFPGASIASTPP-LDTSTTFTP------STDTASTPTIPVATTISVSVITEGSTPGT 3937

Query: 1296 TVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESS 1355
            T+     PV S TA+ F +   +       ST L  P+ ++     S         P  +
Sbjct: 3938 TIFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMT 3997

Query: 1356 AMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEP 1415
              A L    ++   S+  T     T +    S  + P          VT   P   +  P
Sbjct: 3998 TAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVT---PSSESSRP 4054

Query: 1416 SV-------PVLEPAVSVLQPSMIVSEPSVS----------VQESTVTVSEPAVTVSEQT 1458
            S        P   PA S   P+   S  +V+           + ST T S P VT    T
Sbjct: 4055 STITSHTIPPTFPPAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTSFPTVT----T 4110

Query: 1459 QVIPTEVAIESTP 1471
              +PT   I+S P
Sbjct: 4111 TAVPTNTTIKSNP 4123



 Score =  103 bits (256), Expect = 3e-21
 Identities = 176/801 (21%), Positives = 300/801 (37%), Gaps = 75/801 (9%)

Query: 163  SAVALELPTRAFGPSETNESPAVVLEP------PVVSMEVSEPHILETLKPATK------ 210
            SA A   PT A GPS +N +P+    P       V+ +  SE   L T   AT       
Sbjct: 250  SAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITS 309

Query: 211  --------TAELSVVSTSVISEQSEQ--SVAVMPEPSMTKILDSFAAAPVPTTTLVLKSS 260
                    TAE + + TS  +E S    S      P  T  + + +  PV T+TLV  S+
Sbjct: 310  TEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMSTLSITPVDTSTLVTTST 369

Query: 261  EPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEP 320
            EP  ++    +  S+L S  S    P   M V   +    E S T  +  ++ T V    
Sbjct: 370  EPS-SLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTAS 428

Query: 321  STSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASA 380
              S++    E ++I            PSE +    + P     +  + A  L  + V S 
Sbjct: 429  EASSSPTTAEDTSIAT--------STPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSK 480

Query: 381  MELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELP--GPPATAVPEL 438
             ++     TS      PP   V  +P  ++TP        S  V  +P     A+ +   
Sbjct: 481  TQV----TTSTEASSSPPTAEVNSMP--TSTPSEGSTPLTSMSVSTMPVASSEASTLSTT 534

Query: 439  PGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVT 498
            P  + TPV   S+       P  G   P   P     +  L  +P+ T  V +  + + T
Sbjct: 535  PVDTSTPVTTSSEASSSSTTPE-GTSIPTSTPSEG--STPLTNMPVSTRLV-VSSEASTT 590

Query: 499  VAMELTEQPVTTTELEQPVGMTTVEHPGHPEVT------------TATGLLGQPEATMVL 546
                       TT  E     TT E    P  T             +T L+   EA+ + 
Sbjct: 591  STTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVASSEASTLS 650

Query: 547  ELP---GQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPLMAA 603
              P     PV TT+ E     +      +P       +  L+  PV T  L         
Sbjct: 651  TTPVDSNTPV-TTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNT-TLVASSEASTL 708

Query: 604  GALEFSGQSGAAGALELLGQPLATGVLELPGQP---GAPELPGQPVATVALEISVQSVVT 660
                    +    + E    P       +P      G+  L   PV+   L  S  S ++
Sbjct: 709  STTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLS 768

Query: 661  TSELSTMT-VSQSLEV---PSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAPESHIL 716
            T+ L T T ++ S E    P+TT   S         + L+  TS+ V + P+ +PE+  L
Sbjct: 769  TTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLL--TSIPVSITPVTSPEASTL 826

Query: 717  ASNTMETHILASNTMDSQMLASNTMDSQMLASNTMDSQM-LASSTMDSQMLATSSMDSQM 775
            ++  ++++   + + +     +    + M  S   + +  L S  + + ++ATS++ +  
Sbjct: 827  STTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAIST-- 884

Query: 776  LATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQM 835
            L+T+ +D+    T++ +++   T+S  + M  ++  +     TS  DS     SS    +
Sbjct: 885  LSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTL 944

Query: 836  LATSTMDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQMLASGTMDAQMLA---SGTMD 892
             AT    S  + TST  +    T+   S   ++ +  +  L S  +   ++A   + T+ 
Sbjct: 945  SATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLS 1004

Query: 893  AQMLASSTQDSAMLGSKSPDP 913
               + S+T  +    + SP P
Sbjct: 1005 TTPVDSNTPLTTSTEASSPPP 1025



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 172/803 (21%), Positives = 308/803 (38%), Gaps = 86/803 (10%)

Query: 160  SEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHI--LETLKPATKTAELSVV 217
            S  +A    +PT A+    T  +   +    VVS E S      ++T  PAT + E S  
Sbjct: 1966 SPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSS 2025

Query: 218  STSV------ISEQSEQSVAVMPEPSMTKIL-----DSFAAAPVPTTTLVLKSSEPVVTM 266
             T+        S  SE++  +   P  T ++     ++ +  PV + T V  S+E   + 
Sbjct: 2026 PTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSA 2085

Query: 267  SVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKV---------LEPSETLVVSSETPTEVY 317
            + E    ++    E  SP  + I L   PVA           ++ +  ++ S+E  +   
Sbjct: 2086 TAEGSSMTISAPSEG-SPLLTSIPLSTTPVASPEASTLSTTPVDSNSPVITSTEVSSSPI 2144

Query: 318  PEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSV 377
            P   TS               +P     V S    +  T P +    P T + E + S  
Sbjct: 2145 PTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDT-STPVTNSTEARSSPT 2203

Query: 378  AS---AMELPGP-----PATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPG 429
             S   +M    P     P TSMP    P VT   E    SATPV        T  P    
Sbjct: 2204 TSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTS--EASTLSATPV-------DTSTPVTTS 2254

Query: 430  PPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAV 489
              AT+ P     +  P   LS+          G  P   +P    +        L T  V
Sbjct: 2255 TEATSSPTTAEGTSIPTSTLSE----------GTTPLTSIPVSHTLVANSEVSTLSTTPV 2304

Query: 490  ELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELP 549
            +       T + E +  P T      P   ++  +     +  +T ++   E + +   P
Sbjct: 2305 D--SNTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTP 2362

Query: 550  GQ---PVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPLMAAGAL 606
                 PV TT  +    P+      +P    +  +  L+  PV+T  + +          
Sbjct: 2363 ADTSTPV-TTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPV-VSSEASTHSTT 2420

Query: 607  EFSGQSGAAGALELLGQPLATGVLELPGQP---GAPELPGQPVATVALEISVQSVVTTSE 663
                 +    + E    P       +P  P   G   L   PV+T  +  S    ++T+ 
Sbjct: 2421 PVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTP 2480

Query: 664  LSTMTVSQSLEVPSTTALESYN--TVAQEL--PTTLVGE-----TSVTVGVDPLMAPESH 714
            + T T       P TT+ E+ +  T A+++  P +   E     TS+ V   P+ +PE+ 
Sbjct: 2481 VDTST-------PMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEAS 2533

Query: 715  ILASNTMETHI-LASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLATSSMDS 773
             L++  ++++  + ++T  S    S    S   ++ +  S  L S  + ++ LA+S  ++
Sbjct: 2534 TLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASS--EA 2591

Query: 774  QMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDS 833
              L+T+ +D+ +  T++ ++    T++ D+ M  ++  +     TS + S M   SS ++
Sbjct: 2592 STLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASS-EA 2650

Query: 834  QMLATSTMDSQMLATSTMDSQMLATSSMDSQMLAS-----GTMDSQMLASGTMDAQMLAS 888
              L+T+ +D++ L T++  +    T++  S M  S      T  + +L S T+ A   AS
Sbjct: 2651 STLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEAS 2710

Query: 889  GTMDAQMLASSTQDSAMLGSKSP 911
                  +  S+   ++   S SP
Sbjct: 2711 TLSTTPVDTSTPVTTSAEASSSP 2733



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 288/1410 (20%), Positives = 506/1410 (35%), Gaps = 166/1410 (11%)

Query: 160  SEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHI--LETLKPATKTAELSVV 217
            S  +A    +PT   G   T  +  +V    + + E S      ++T  P T +AE S  
Sbjct: 2673 SPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTLSTTPVDTSTPVTTSAEASSS 2732

Query: 218  STSV------ISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQ 271
             T+       IS  S+ S  +      T  + S  A+ V TT +   +S PV T +    
Sbjct: 2733 PTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEASTVSTTAV--DTSIPVTTSTEASS 2790

Query: 272  MKSVLK--SVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFP 329
              +  +  S+ +++P  +   L   PV      S      S TP +     +TST     
Sbjct: 2791 SPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTSTKASSS 2850

Query: 330  ESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGP-PA 388
             ++A        + + VP   A    T    +P    TT +   E+S  S   +    P 
Sbjct: 2851 PTTA--------EGIVVPISTASEGSTLLTSIPV--STTPVASSEASTLSTTPVDTSIPV 2900

Query: 389  TSMPELQGPPVTPV-----LELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSV 443
            T+  E    P T       +  P   +TP+  +   L + VP + G  A+ +   P  + 
Sbjct: 2901 TTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSI---LVSTVP-VAGSEASTLSTTPVDTR 2956

Query: 444  TPVPQLSQELPGLPAPSMGLEPPQEVP---EPPVMAQELPGLPLVTA-AVELPEQPAVTV 499
            TPV   S E    P  + G   P   P     P+ +  +  +P+ ++ A  L   PA T 
Sbjct: 2957 TPVTT-SAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTPADT- 3014

Query: 500  AMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALE 559
                   PVTT+  E     TT E  G P  T + G            L   PV+TT + 
Sbjct: 3015 -----STPVTTST-EASSSPTTAEGTGIPISTPSEGST---------PLTSIPVSTTPVA 3059

Query: 560  LPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPLMAAGALEFSG--------Q 611
            +P   +++  P     P  T + E+S  P       +P    + G+   +G         
Sbjct: 3060 IPEASTLSTTPVDSNSPVVT-STEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVT 3118

Query: 612  SGAAGALELLGQPLATGVL---ELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMT 668
            S A   L       +T V    E    P   E    P +T +          ++ L+ M 
Sbjct: 3119 SSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPS--------EGSTPLTYMP 3170

Query: 669  VSQSLEV----------------PSTTALESYNTVAQE---LPTTLVGE-----TSVTVG 704
            VS  L V                P TT+ E+ ++   E   +PT+   E     TSV V 
Sbjct: 3171 VSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVS 3230

Query: 705  VDPLMAPESHILASNTMETHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQ 764
              P+ + E+ IL++  ++++   + + ++   +  T +   + ++T        ++M   
Sbjct: 3231 NTPVASSEASILSTTPVDSNTPLTTSTEASS-SPPTAEGTSMPTSTPSEGSTPLTSMPVS 3289

Query: 765  MLATSSMDSQMLATSSMDSQMLATS---------TMDSQMLATSSMDSQMLATSSMDSQM 815
                +S ++  L+T+  D+    T+           D   + TS+        ++M    
Sbjct: 3290 TTTVASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFST 3349

Query: 816  LATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLATSSMDSQMLASGTMDSQM 875
                S ++  L+T+ +D+    T++ ++  L+ +T +   + TSS         +M    
Sbjct: 3350 TPVVSSEASTLSTTPVDTSTPVTTSTEAS-LSPTTAEGTSIPTSSPSEGTTPLASMPVST 3408

Query: 876  LASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDPYRLAQDPYRLAQDPYRLGHDPY 935
                + +   L++  +D+  L +++ ++    S SP        P     +    G  P 
Sbjct: 3409 TPVVSSEVNTLSTTPVDSNTLVTTSTEA----SSSPTIAEGTSLPTSTTSE----GSTPL 3460

Query: 936  RLGHDAYRLGQDPYRLGHDPYRLTPDPYRMSPRPYRIAPRSYRIAPRPYRLAPRPLMLAS 995
             +      L   P     +   L+  P   S      +P +   +P    +   P   A 
Sbjct: 3461 SI----MPLSTTPV-ASSEASTLSTTPVDTSTPVTTSSPTN--SSPTTAEVTSMPTSTAG 3513

Query: 996  RRSM-MMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMA 1054
              S  + +     + ++S E S +S      +     S  ++   + +      M +P  
Sbjct: 3514 EGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSE 3573

Query: 1055 ERSMMSAYERS---MMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSM-MSSYSAA 1110
              S ++    S   + S+   +  +P  DRS     + +S  +       ++ MS+ S  
Sbjct: 3574 GSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEV 3633

Query: 1111 DRSM----MSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEE-- 1164
               +    +S+ +   S    A+    D+ T   T   +       E  TMP   P E  
Sbjct: 3634 STPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGS 3693

Query: 1165 -PPMTPPLPPEE--PPEGPALPTEQSALTAENTWPTEVPSSPS--EESVSQPEPPVSQSE 1219
             P  T P+        EG  L T     +   T  TE  SS +  + +      P+  S 
Sbjct: 3694 TPLTTMPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEIST 3753

Query: 1220 ISEPSAVPT------DYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEH 1273
            +     V T        S + S PSV  S +  T  E    P +    T +  +  +E  
Sbjct: 3754 LGTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERS 3813

Query: 1274 EVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVST--SLLV 1331
             ++     T ++S    MS       S PP  + T     +   S  + +EV+T    + 
Sbjct: 3814 TLL----TTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISIT 3869

Query: 1332 PAVTTPV--LAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVV 1389
               +TP+  L  S   P +      ++   L++S      + T +       T +  SV+
Sbjct: 3870 SERSTPLTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVI 3929

Query: 1390 TVPEPPVVAEPDYVTIP-VPVVSALEPSVPVLEPAVSV-LQPSMIVSEPSVSVQESTVTV 1447
            T    P       + IP  PV S+     P    AVS  +  S  ++ PS S   +T + 
Sbjct: 3930 TEGSTPGTT----IFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSF 3985

Query: 1448 S------EPAVTVSEQTQVIPTEVAIESTP 1471
            S       PA+T +     +    A  STP
Sbjct: 3986 STTKEFTTPAMTTAAPLTYVTMSTA-PSTP 4014



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 179/826 (21%), Positives = 299/826 (36%), Gaps = 79/826 (9%)

Query: 136  SESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSME 195
            SE+ T S     I ++S +F+   SE S+        +   S  +E    +   PV +  
Sbjct: 408  SEASTTS----TIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTP 463

Query: 196  V--SEPHILETLKPATKT--------------AELSVVSTSVISEQSEQ--SVAVMPEPS 237
            V  SE   L T    +KT              AE++ + TS  SE S    S++V   P 
Sbjct: 464  VASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPV 523

Query: 238  MTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVA 297
             +    + +  PV T+T V  SSE   + S   +  S+  S  S    P   M V   + 
Sbjct: 524  ASSEASTLSTTPVDTSTPVTTSSE-ASSSSTTPEGTSIPTSTPSEGSTPLTNMPVSTRLV 582

Query: 298  KVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTR 357
               E S T    +++ T V      S++    E +++      E+   + S    +++  
Sbjct: 583  VSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLVA 642

Query: 358  PQELPEL---------PKTTALELQESSVASAMELPGPPATSMP-ELQGPPVTPVLELPG 407
              E   L         P TT+ E   SS  +         TSMP        TP+  +P 
Sbjct: 643  SSEASTLSTTPVDSNTPVTTSTEATSSSTTAE-------GTSMPTSTYTEGSTPLTSMPV 695

Query: 408  PSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQ 467
             +          LST   +   P  T+      P+      +         PS G  P  
Sbjct: 696  NTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTS-----TPSEGSTPLT 750

Query: 468  EVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGH 527
             +P    +        L T  ++      +T + E +  P TT     P+   +   P  
Sbjct: 751  SMPVSKTLLTSSEASTLSTTPLDTSTH--ITTSTEASCSPTTTEGTSMPISTPSEGSPLL 808

Query: 528  PEVTTATGLLGQPEATMVLELP---GQPVATTALELPGQPSVTGVPELPGLPSATRALEL 584
              +  +   +  PEA+ +   P     PV TT+ E+   P+      +P    +     L
Sbjct: 809  TSIPVSITPVTSPEASTLSTTPVDSNSPV-TTSTEVSSSPTPAEGTSMPTSTYSEGRTPL 867

Query: 585  SGQPVATGALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQP---GAPEL 641
            +  PV+T  L     +           +    + E    P  +    +P      G+  L
Sbjct: 868  TSMPVST-TLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPGEGSTPL 926

Query: 642  PGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQ--ELPTTLVGET 699
               P +T  +   V S   T  LS   V  S  V ++T   S  T A+   +PT+   E 
Sbjct: 927  TSMPDSTTPV---VSSEART--LSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSE- 980

Query: 700  SVTVGVDPLMA-PESHILASN----TMETHILASNT-MDSQMLASN---TMDSQMLASNT 750
                G  PL + P SH L +N    T+ T  + SNT + +   AS+   T +   + ++T
Sbjct: 981  ----GTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTST 1036

Query: 751  MDSQMLASSTMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSS 810
                    + M       +S ++  L+T+  D+    T+   +   +T++  + M  ++ 
Sbjct: 1037 PSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGTSMPTSTY 1096

Query: 811  MDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLATSSMDSQMLASGT 870
             +     TS   S  L  SS  S +  T    S  + TST  S    T+   S   +  +
Sbjct: 1097 SEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTSIPTSPPS 1156

Query: 871  MDSQMLASGTMDAQMLAS---GTMDAQMLASSTQDSAMLGSKSPDP 913
              +  LAS  +   ++ S    T+    + S TQ +    + SP P
Sbjct: 1157 EGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPP 1202



 Score = 88.6 bits (218), Expect = 7e-17
 Identities = 147/698 (21%), Positives = 267/698 (38%), Gaps = 83/698 (11%)

Query: 246 AAAPVPTTTLVLKSSEP--VVTMSVEYQMKSVLKSVESTSPEPSKIMLV---EPPVAKVL 300
           +AA   T T      EP   ++ S   +M S+  SV S +P  S   +        ++  
Sbjct: 63  SAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSDTPGVSSTRMTPTESRTTSEST 122

Query: 301 EPSETLVVSS--ETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRP 358
             S TL  SS  +T +   PE  T   M  P   +I +         +PS  A +S+T  
Sbjct: 123 SDSTTLFPSSTEDTSSPTTPE-GTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYK 181

Query: 359 QELPELPKTTALELQESSVASAMELPGPPATSMPE-LQGPPVTPVLELPGPSATPVPELP 417
            ++   P TT+ +   S          P +T++P+       TP+  +P  +        
Sbjct: 182 VDM-STPLTTSTQASSSPTT-------PESTTIPKSTNSEGSTPLTSMPASTMKVASSEA 233

Query: 418 GPLSTPVPELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPP--VM 475
             L T   E+  P   +      P+    P LS       APS G  P   +P     V+
Sbjct: 234 ITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNS-----APSGGSTPLTRMPLSVMLVV 288

Query: 476 AQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATG 535
           + E   L    AA  +P    V  + E +  P T      P    T           +T 
Sbjct: 289 SSEASTLSTTPAATNIP----VITSTEASSSPTTAEGTSIPTSTYT---------EGSTP 335

Query: 536 LLGQPEATMVLELPGQPVATTALE------LPGQPSVTGVPELPGLPSATRALELSGQPV 589
           L   P +TM       PVAT+ +       +     VT   E   LP+   A  +    +
Sbjct: 336 LTSTPASTM-------PVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTL 388

Query: 590 ATGALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQP------------- 636
           + G+  L   +  +  L  S ++     + +  +   T   E    P             
Sbjct: 389 SEGSTPLTN-MPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTP 447

Query: 637 --GAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQ--ELP 692
             G+  L   PV+T  +  S       S LST  V    +V ++T   S    A+   +P
Sbjct: 448 SEGSTPLTSMPVSTTPVASS-----EASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMP 502

Query: 693 TTLVGE-----TSVTVGVDPLMAPESHILASNTMETHILASNTMDSQMLASNTMDSQMLA 747
           T+   E     TS++V   P+ + E+  L++  ++T    + + ++   +S T +   + 
Sbjct: 503 TSTPSEGSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASS-SSTTPEGTSIP 561

Query: 748 SNTMDSQMLASSTMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLA 807
           ++T        + M        S ++   +T+  DS    T++ ++   +T++  + M  
Sbjct: 562 TSTPSEGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSM-P 620

Query: 808 TSSMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLATSSMDSQMLA 867
           TS+   +    +SM       +S ++  L+T+ +DS    T++ ++   +T++  + M  
Sbjct: 621 TSTYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPT 680

Query: 868 SG-TMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSA 904
           S  T  S  L S  ++  ++AS   +A  L+++  D++
Sbjct: 681 STYTEGSTPLTSMPVNTTLVASS--EASTLSTTPVDTS 716



 Score = 80.9 bits (198), Expect = 1e-14
 Identities = 177/819 (21%), Positives = 324/819 (39%), Gaps = 101/819 (12%)

Query: 150 LESDSFLKFDSEPSAVALELPTRAFGPSETNESPAV--VLEPPVVSMEVSEPHILETLKP 207
           +E   +L   + P   ++E        S T+++P V      P  S   SE     T   
Sbjct: 77  VEPRMYLSCSTNPEMTSIE-------SSVTSDTPGVSSTRMTPTESRTTSESTSDSTTLF 129

Query: 208 ATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPT----TTLVLK--SSE 261
            + T + S  +T    E ++  ++   E S++  +   + AP+P+    T+L  K   S 
Sbjct: 130 PSSTEDTSSPTTP---EGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMST 186

Query: 262 PVVTMSVEYQMKSVLKSV---ESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYP 318
           P+ T +      +  +S    +ST+ E S  +   P     +  SE + + + TP E+  
Sbjct: 187 PLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEAITLLT-TPVEI-- 243

Query: 319 EPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVA 378
             ST  T+    SS+      P      PS  +      P  +  +  + A  L  +  A
Sbjct: 244 --STPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAA 301

Query: 379 SAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPL-STPVPELPGPPATAVPE 437
           + +    P  TS      P       +P  + T   E   PL STP   +P     A  E
Sbjct: 302 TNI----PVITSTEASSSPTTAEGTSIPTSTYT---EGSTPLTSTPASTMP----VATSE 350

Query: 438 LPGPSVTPVPQ-----LSQELPGLPAP-----------SMGLEPPQEVPEPPVMAQELPG 481
           +   S+TPV        S E   LP             S G  P   +P   ++      
Sbjct: 351 MSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEA 410

Query: 482 LPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHP--EVTTATGLLGQ 539
               T+ + +  +  VT A E +  P  TT  +  +  +T      P   +  +T  +  
Sbjct: 411 S--TTSTIPVDSKTFVTTASEASSSP--TTAEDTSIATSTPSEGSTPLTSMPVSTTPVAS 466

Query: 540 PEATMVLELP--GQPVATTALELPGQPSVTGVPELP-GLPSA----TRALELSGQPVATG 592
            EA+ +   P   +   TT+ E    P    V  +P   PS       ++ +S  PVA+ 
Sbjct: 467 SEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSEGSTPLTSMSVSTMPVASS 526

Query: 593 ALELPG--PLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVAT-- 648
                   P+  +  +  S ++ ++        P  T +       G+  L   PV+T  
Sbjct: 527 EASTLSTTPVDTSTPVTTSSEASSSSTT-----PEGTSIPTSTPSEGSTPLTNMPVSTRL 581

Query: 649 -VALEISVQS---------VVTTSELSTM-TVSQSLEVPSTTALESYNTV-AQELPTTLV 696
            V+ E S  S         V T+SE S+  T ++   +P++T  E   T+ +  + TTLV
Sbjct: 582 VVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTTLV 641

Query: 697 GETSV-TVGVDPLMAPESHILASNTMETHILASNTMDSQMLASNTMDSQMLASNTMDSQM 755
             +   T+   P+ +      ++    +   A  T  S   ++ T  S  L S  +++ +
Sbjct: 642 ASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGT--SMPTSTYTEGSTPLTSMPVNTTL 699

Query: 756 LASSTMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQM 815
           +ASS  ++  L+T+ +D+    T+S ++    T+   + M  ++  +     TS   S+ 
Sbjct: 700 VASS--EASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPLTSMPVSKT 757

Query: 816 LATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQM-LATSSMDSQMLASGTMDSQ 874
           L TSS ++  L+T+ +D+    T++ ++    T+T  + M ++T S  S +L S  +   
Sbjct: 758 LLTSS-EASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEGSPLLTSIPVSIT 816

Query: 875 MLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDP 913
            + S   +A  L++  +D+    +++ +     S SP P
Sbjct: 817 PVTS--PEASTLSTTPVDSNSPVTTSTEV----SSSPTP 849



 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 125/496 (25%), Positives = 199/496 (40%), Gaps = 65/496 (13%)

Query: 1019 SYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPM 1078
            S E S   P AE + M     S  S    SM  P++  ++ S+ E S +S       +P+
Sbjct: 3256 STEASSSPPTAEGTSMPTSTPSEGSTPLTSM--PVSTTTVASS-ETSTLSTTPADTSTPV 3312

Query: 1079 ADRSMMSMG---ADRSMM--SSYSAADRSMMS-SYS-----AADRSMMSSYTADRSMMSM 1127
               S  S     AD + M  S+YS     + + S+S     +++ S +S+   D S  + 
Sbjct: 3313 TTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTS--TP 3370

Query: 1128 AADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQS 1187
               S   S + T  E   +P   P E  T  PL    P  T P+   E       P + +
Sbjct: 3371 VTTSTEASLSPTTAEGTSIPTSSPSEGTT--PLA-SMPVSTTPVVSSEVNTLSTTPVDSN 3427

Query: 1188 ALTAENTWPTEVPSSPS-EESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAV 1246
             L    T  TE  SSP+  E  S P    S+          T  S+     + + S  A 
Sbjct: 3428 TLV---TTSTEASSSPTIAEGTSLPTSTTSEGS--------TPLSIMPLSTTPVASSEAS 3476

Query: 1247 TVPEPPPEPESSITLT-PVESAVVAEEHEVVP-------ERPVTCM-VSETPAMSAEPTV 1297
            T+   P +  + +T + P  S+    E   +P         P+T M VS TP  S+E + 
Sbjct: 3477 TLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEAST 3536

Query: 1298 LASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAM 1357
            L S  PV S T  T  S  +S     +V+T  +    +TP    S L    +++   ++ 
Sbjct: 3537 L-STTPVDSNTFVTSSSQASSSPATLQVTTMRM----STPSEGSSSLTTMLLSSTYVTSS 3591

Query: 1358 AVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSV 1417
                 S  +V  S+ VT    S  T   P V+T+P    ++ P  V+ P+ ++     SV
Sbjct: 3592 EASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLP----MSTPSEVSTPLTIMPVSTTSV 3647

Query: 1418 PVLEPAVSVLQP---------SMIVSEPSVSVQESTVTV------SEPAVTVS-EQTQVI 1461
             + E   +   P         S  VS   V+ + +T+ +      S P  T+    T+V 
Sbjct: 3648 TISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVT 3707

Query: 1462 PTEVAIESTPMILESS 1477
             +E +  STP ++ S+
Sbjct: 3708 SSEGSTLSTPSVVTST 3723



 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 245/1118 (21%), Positives = 404/1118 (36%), Gaps = 131/1118 (11%)

Query: 636  PGAPELPGQPVATVALEI--SVQSVVTTSEL------STMTVSQSLEVPSTTALESYNTV 687
            P  PE    P++T + E   S  + V+T+ L      +++T    +  P TT+ ++ ++ 
Sbjct: 139  PTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSP 198

Query: 688  AQELPTTLVGETSVTVGVDPLMA--------PESHILASNTMETHILASNTMDSQMLASN 739
                 TT+   T+ + G  PL +          S  +   T    I    T+ +Q  +S 
Sbjct: 199  TTPESTTIPKSTN-SEGSTPLTSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSP 257

Query: 740  TMDSQMLASNTMDSQMLASSTMD--SQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLA 797
            T       SN+  S      T    S ML  SS  S +  T +  +  + TST  S    
Sbjct: 258  TTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPT 317

Query: 798  TSSMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLA 857
            T+   S   +T +  S  L ++   +  +ATS M +  L+ + +D+  L T++ +   L 
Sbjct: 318  TAEGTSIPTSTYTEGSTPLTSTPASTMPVATSEMST--LSITPVDTSTLVTTSTEPSSLP 375

Query: 858  TSSMDSQMLAS-----GTMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPD 912
            T++  + ML S      T  + M  S  + A   AS T    + + +   +A   S SP 
Sbjct: 376  TTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPT 435

Query: 913  PYRLAQDPYRLAQDPYRLGHDPYRLGHDAYRLGQDPYRLGHDPYRLTP----DPYRMSPR 968
                A+D       P                 G  P  L   P   TP    +   +S  
Sbjct: 436  T---AEDTSIATSTPSE---------------GSTP--LTSMPVSTTPVASSEASNLSTT 475

Query: 969  PYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSM-MSSYERSMMSYERSMMSP 1027
            P        ++       +  P   A   SM  S  +E S  ++S   S M    S  S 
Sbjct: 476  P---VDSKTQVTTSTEASSSPPT--AEVNSMPTSTPSEGSTPLTSMSVSTMPVASSEAST 530

Query: 1028 MAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMG 1087
            ++   + ++    + ++ E S  S   E + +     S  S    +M  P++ R ++S  
Sbjct: 531  LSTTPVDTS--TPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTNM--PVSTRLVVS-- 584

Query: 1088 ADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVP 1147
            ++ S  S+  A   + +++ S A  S   S TA+ +  SM   +Y++  T   + +    
Sbjct: 585  SEASTTSTTPADSNTFVTTSSEASSS---STTAEGT--SMPTSTYSERGTTITSMSVSTT 639

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENT-WPTEVPSSPSEE 1206
             +   E  T+   P +             P   +     S+ TAE T  PT   +  S  
Sbjct: 640  LVASSEASTLSTTPVDS----------NTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTP 689

Query: 1207 SVSQPEPP--VSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPV 1264
              S P     V+ SE S  S  P D S   +  S   S +  T      +  S  T TP 
Sbjct: 690  LTSMPVNTTLVASSEASTLSTTPVDTSTPVTT-STEASSSPTTA-----DGASMPTSTPS 743

Query: 1265 ESAVVAEEHEVVPERPVTCM-VSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVAS 1323
            E +            P+T M VS+T   S+E + L++ P   S    T      S     
Sbjct: 744  EGST-----------PLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTE 792

Query: 1324 EVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTV 1383
              S  +  P+  +P+L    +    + +PE+S +     S   V  +S VT   +ST   
Sbjct: 793  GTSMPISTPSEGSPLLTSIPVSITPVTSPEASTL-----STTPVDSNSPVT---TSTEVS 844

Query: 1384 LEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQES 1443
              P   T  E   +    Y     P+ S    +  V   A+S L  + +  + S  V  S
Sbjct: 845  SSP---TPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPV--DTSTPVTNS 899

Query: 1444 TVTVSEPAVTVSEQTQVIPTEVAIESTPMI-LESSIMSSHVMKGINLSSGDQNLAPEIGM 1502
            T   S P  T SE T +  +     STP+  +  S       +   LS+   + +  +  
Sbjct: 900  TEARSSP--TTSEGTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTT 957

Query: 1503 QEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIG 1562
               A  S     AE         SE    +     +H +    E +T+    T+PV    
Sbjct: 958  STEATSS--PTTAEGTSIPTSTPSEGTTPLTSTPVSHTLVANSEASTL---STTPVDSNT 1012

Query: 1563 EEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSL 1622
                   + +   T   T    S    G T  +  P +    A+  +  +  T A T + 
Sbjct: 1013 PLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTP 1072

Query: 1623 VNKYDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDL---PSNNNLVSKDT 1679
            V  Y    S +T      M  ST   G +      PL +  +   L      + L +   
Sbjct: 1073 VTTYSQASSSSTTADGTSMPTSTYSEGST------PLTSVPVSTRLVVSSEASTLSTTPV 1126

Query: 1680 EEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLP 1717
            +  +PV  S +   A  SP  + G      PP + T P
Sbjct: 1127 DTSIPVTTSTE---ASSSPTTAEGTSIPTSPPSEGTTP 1161



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 159/766 (20%), Positives = 273/766 (35%), Gaps = 54/766 (7%)

Query: 1040 SMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGAD----RSMMSS 1095
            S +S     + S     ++++  E S +S       SP+   + +S         S+ +S
Sbjct: 1801 STLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIATS 1860

Query: 1096 YSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPP 1155
              +   + ++S   +  ++ SS T   S       + T +   TY +    P     +  
Sbjct: 1861 TPSEGSTALTSIPVSTTTVASSETNTLS----TTPAVTSTPVTTYAQVSSSPTTA--DGS 1914

Query: 1156 TMPPLPPEE--PPMTPPLPPEEPPEGPALPTEQSALTAENTWP----TEVPSSPSE-ESV 1208
            +MP   P E  PP+T  +P        +     S   A+   P    ++  SSP+  +  
Sbjct: 1915 SMPTSTPREGRPPLTS-IPVSTTTVASSEINTLSTTLADTRTPVTTYSQASSSPTTADGT 1973

Query: 1209 SQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAV 1268
            S P P  S+      S   +   V +S+ S L +    T        E S + T      
Sbjct: 1974 SMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTS 2033

Query: 1269 VAEEHEVVPERPVTCM-VSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVST 1327
            +          P+  M VS T  +S+E   L S  PV S+T  T  +  +S   A   S 
Sbjct: 2034 IQTSTPSERTTPLAGMPVSTTLVVSSEGNTL-STTPVDSKTQVTNSTEASSSATAEGSSM 2092

Query: 1328 SLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPS 1387
            ++  P+  +P+L    L    +A+PE+S +            S+T     S  +T  E S
Sbjct: 2093 TISAPSEGSPLLTSIPLSTTPVASPEASTL------------STTPVDSNSPVITSTEVS 2140

Query: 1388 VVTVP-EPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVT 1446
               +P E   +    Y     P+ S    +  V   A+S L  + +  + S  V  ST  
Sbjct: 2141 SSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPV--DTSTPVTNSTEA 2198

Query: 1447 VSEPAVTVSEQTQVIPTEVAIESTPMI-LESSIMSSHVMKGINLSSGDQNLAPEIGMQEI 1505
             S P  T SE T +  +  +  STP   +  S M     +   LS+   + +  +     
Sbjct: 2199 RSSP--TTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPVTTSTE 2256

Query: 1506 ALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEK 1565
            A  S               E    +   + +++ L+A    ++ V    T+PV       
Sbjct: 2257 ATSSPTTAEGTSIPTSTLSEGTTPLT-SIPVSHTLVA----NSEVSTLSTTPVDSNTPFT 2311

Query: 1566 ILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNK 1625
                + +   T   T    S +  G T  +  P +    A+  +  +  T A T + V  
Sbjct: 2312 TSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTT 2371

Query: 1626 YDVDLSLTTQDTEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPV 1685
            Y    S  T   +  M  ST  S GS      P+    +     S ++    DT  P+  
Sbjct: 2372 YSQAGSSPTTADDTSMPTSTY-SEGSTPLTSVPVSTMPVVSSEASTHSTTPVDTSTPVTT 2430

Query: 1686 KESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDI--NEADLVRPLLPKDME 1743
                 +  A  SP  + G      PP + T P +    +   +  +EA  +         
Sbjct: 2431 -----STEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTPVDTST 2485

Query: 1744 RLTSLRAGIEGPLLASDVGRDRSAA---SPVVSSMPERASESSSEE 1786
             +T+       P  A D+    S A   S +++S+P   +  +S E
Sbjct: 2486 PMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPE 2531



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 143/741 (19%), Positives = 255/741 (34%), Gaps = 80/741 (10%)

Query: 32   QLNGETNTPIEGNQAGDAAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSR 91
            ++N  + TP++ N     +  A S P       +    +    T L   P        S 
Sbjct: 3415 EVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASSE 3474

Query: 92   CVSVQTDPTD-------EIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHD 144
              ++ T P D         PT  S    +  +       E        P  +     S  
Sbjct: 3475 ASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEA 3534

Query: 145  D--GNIDLESDSFLKFDSEPSA--VALELPT-RAFGPSETNESPAVVL--EPPVVSMEVS 197
                   ++S++F+   S+ S+    L++ T R   PSE + S   +L     V S E S
Sbjct: 3535 STLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEAS 3594

Query: 198  EPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVL 257
             P       P+   +     ST   S  +   V  +P  + +++       PV TT++ +
Sbjct: 3595 TPST-----PSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTSVTI 3649

Query: 258  KSSEPVVTMSVEYQMKSVLKSVESTS---PEPSKIMLVEPPVAK----VLEPSETLVVSS 310
              +    T+ V+     +  +  S+S   PE + + +  P         +  S T V SS
Sbjct: 3650 SEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTTMPVSTTRVTSS 3709

Query: 311  E-----TPTEVYPEPSTSTTMDFPESSAIEALRLP-EQPVDVPSEIADSSMTRPQELPEL 364
            E     TP+ V   P T++T     S+ +++  +    P+++ S +  + +     +   
Sbjct: 3710 EGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEI-STLGTTILVSTTPVTRF 3768

Query: 365  PKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPV 424
            P+++   +     + +M      ++S   L+G    P+      S      L  P+S   
Sbjct: 3769 PESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMS 3828

Query: 425  PELPGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPL 484
            P      A+ +   PG + TP+      L    A S  +  P EV    +        PL
Sbjct: 3829 PS----EASTLSTPPGDTSTPL------LTSTKAGSFSI--PAEVTTIRISITSERSTPL 3876

Query: 485  VTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEVTTATGLL---GQPE 541
             T  V      +   A   +  P+ T+    P    T   P  P  TT +  +   G   
Sbjct: 3877 TTLLVSTTLPTSFPGASIASTPPLDTSTTFTP-STDTASTPTIPVATTISVSVITEGSTP 3935

Query: 542  ATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVATGALELPGPLM 601
             T +  +P  PV ++  ++   P+ TG    P + S                L  P    
Sbjct: 3936 GTTIF-IPSTPVTSSTADV--FPATTGAVSTPVITST--------------ELNTPSTSS 3978

Query: 602  AAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVALEISVQSVV-T 660
            ++    FS              PL    + +   P  P    +   T A  +S  S   T
Sbjct: 3979 SSTTTSFSTTKEFTTPAMTTAAPLT--YVTMSTAPSTPRTTSRGCTTSASTLSATSTPHT 4036

Query: 661  TSELSTMTVSQSLEVPSTTALESYN-------TVAQELPTTLVGETSVTVGVDPLMA--- 710
            ++ ++T  V+ S E    + + S+          +   PTT    T+V       M    
Sbjct: 4037 STSVTTRPVTPSSESSRPSTITSHTIPPTFPPAHSSTPPTTSASSTTVNPEAVTTMTTRT 4096

Query: 711  -PESHILASNTMETHILASNT 730
             P +   +  T+ T  + +NT
Sbjct: 4097 KPSTRTTSFPTVTTTAVPTNT 4117



 Score = 58.2 bits (139), Expect = 9e-08
 Identities = 110/460 (23%), Positives = 173/460 (37%), Gaps = 75/460 (16%)

Query: 1041 MMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAAD 1100
            + ++ E S   P AE + M     S  S    SM  P++  ++ S  ++ S +S+  A  
Sbjct: 3253 LTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSM--PVSTTTVAS--SETSTLSTTPADT 3308

Query: 1101 RSMMSSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPL 1160
             + +++YS A  S      AD +  SM   +Y++  T     ++   P+   E  T+   
Sbjct: 3309 STPVTTYSQASSSPP---IADGT--SMPTSTYSEGSTPLTNMSFSTTPVVSSEASTL--- 3360

Query: 1161 PPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTW-PTEVPSSPSEESVSQP--EPPVSQ 1217
                 P+    P     E    PT     TAE T  PT  PS  +    S P    PV  
Sbjct: 3361 --STTPVDTSTPVTTSTEASLSPT-----TAEGTSIPTSSPSEGTTPLASMPVSTTPVVS 3413

Query: 1218 SEISEPSAVPTDYSV-----SASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEE 1272
            SE++  S  P D +      + +  S  ++E          E  + +++ P+ +  VA  
Sbjct: 3414 SEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVASS 3473

Query: 1273 HEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLL-V 1331
                        +S TP  ++ P V  S P   S T     SM  S   A E ST L  +
Sbjct: 3474 E--------ASTLSTTPVDTSTP-VTTSSPTNSSPTTAEVTSMPTS--TAGEGSTPLTNM 3522

Query: 1332 PAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTV 1391
            P  TTPV A S     +    +S+      S A     SS+   L+ +T+ +  PS  + 
Sbjct: 3523 PVSTTPV-ASSEASTLSTTPVDSNTFVTSSSQA-----SSSPATLQVTTMRMSTPSEGSS 3576

Query: 1392 PEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPA 1451
                ++    YVT       A  PS P                    SV  ST       
Sbjct: 3577 SLTTMLLSSTYVTSS----EASTPSTP--------------------SVDRST------P 3606

Query: 1452 VTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSS 1491
            VT S Q+   PT   + + PM   S + +   +  ++ +S
Sbjct: 3607 VTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPVSTTS 3646



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 97/391 (24%), Positives = 157/391 (40%), Gaps = 50/391 (12%)

Query: 1113 SMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLP 1172
            S+ SS T+D   +S    + T+S T + + +      P     T  P  PE   +    P
Sbjct: 93   SIESSVTSDTPGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTP 152

Query: 1173 PEEPPEG-------PALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSA 1225
             EE             LP+ ++  +         P + S ++ S P  P       E + 
Sbjct: 153  SEESISSTMAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTP-------ESTT 205

Query: 1226 VPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMV 1285
            +P   +   S P  L S  A T+     E  + +T TPVE +             ++   
Sbjct: 206  IPKSTNSEGSTP--LTSMPASTMKVASSEAITLLT-TPVEISTPV---------TISAQA 253

Query: 1286 SETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTT-PVLAESIL 1344
            S +P  +AE   L++  P    T  T   +     V+SE ST    PA T  PV+  +  
Sbjct: 254  SSSPT-TAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEASTLSTTPAATNIPVITST-- 310

Query: 1345 EPPAMAAPESSAMAVLESSAVTVLESST-VTVLESSTVTVLEPSVVTVPEPPVVAEPDYV 1403
               A ++P ++    + +S  T  E ST +T   +ST+ V    + T+   PV    D  
Sbjct: 311  --EASSSPTTAEGTSIPTSTYT--EGSTPLTSTPASTMPVATSEMSTLSITPV----DTS 362

Query: 1404 TIPVPVVSALEP-SVPVLEPAVSVLQPSMIV-SEPSVSVQESTVTV--SEPAVT----VS 1455
            T+   V ++ EP S+P    A S+L  ++   S P  ++  ST+ V  SE + T    V 
Sbjct: 363  TL---VTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVD 419

Query: 1456 EQTQVIPTEVAIESTPMILESSIMSSHVMKG 1486
             +T V     A  S     ++SI +S   +G
Sbjct: 420  SKTFVTTASEASSSPTTAEDTSIATSTPSEG 450



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 40/173 (23%), Positives = 62/173 (35%), Gaps = 10/173 (5%)

Query: 160  SEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELS---- 215
            S P   + EL T +   S T  S +   E    +M  + P    T+  A  T   +    
Sbjct: 3962 STPVITSTELNTPSTSSSSTTTSFSTTKEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGC 4021

Query: 216  VVSTSVISEQS--EQSVAVMPEP----SMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVE 269
              S S +S  S    S +V   P    S +    +  +  +P T     SS P  T +  
Sbjct: 4022 TTSASTLSATSTPHTSTSVTTRPVTPSSESSRPSTITSHTIPPTFPPAHSSTPPTTSASS 4081

Query: 270  YQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPST 322
              +     +  +T  +PS      P V     P+ T + S+ T T   P  +T
Sbjct: 4082 TTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTTIKSNPTSTPTVPRTTT 4134


>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
          Length = 715

 Score =  108 bits (270), Expect = 6e-23
 Identities = 123/460 (26%), Positives = 199/460 (43%), Gaps = 71/460 (15%)

Query: 1679 TEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADL-VRPL 1737
            T   +P KE     +   S K  S G+  +P   K   P    S+ ++  N+A    RP 
Sbjct: 221  TPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTE-MSSRVKSYNQASTRSRPQ 279

Query: 1738 LPKDMERLTSLRAG--------IEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDD 1789
                       R+G        +       +  R RS     + S   R S+S S  K  
Sbjct: 280  SHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGK 339

Query: 1790 YEIFVKV-----------KDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRK 1838
             +   +              + E+S  +      E++ +  SS R  S RS+S     ++
Sbjct: 340  SQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQR 399

Query: 1839 RTSESRS--RARKRSSKSKSHRSQTRSRSRSRRRRRS---------SRSRSKSRGRRSVS 1887
              S SRS  +AR RS     ++++ RSRSRS  + R          +R RS+SR      
Sbjct: 400  DHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKAR 459

Query: 1888 KEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR-RRSRSVGRR 1946
               R RSP ++++ R R R  S  RD+ +          RRSRS +  R+ R+SRS  + 
Sbjct: 460  DHSRSRSP-NKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518

Query: 1947 RSFSISPSRRSRTPSRRSRTPSRRSRTPSR-----RSRTPS-----RRSRTPS-----RR 1991
            R       RRSR+PS+  +   R+SR+P++     +SR+PS     R+SR+PS     RR
Sbjct: 519  RDH-----RRSRSPSKERQ--RRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRR 571

Query: 1992 SRTPSR---RRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPK 2048
             R+PS+   RR+SRS    R  S       RSR+P ++     P    + ++  R R+P 
Sbjct: 572  WRSPSKERERRQSRSSSEERDHS-------RSRSPNKQSGYSRPRASSKEKAHSRSRTPS 624

Query: 2049 RLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPT 2088
            +  +  +++      ++  +  +++ VP  P+ K +P  T
Sbjct: 625  KEGNHSQSR-----TSSKESDPSQSTVPRSPDWKRSPTRT 659



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 92/275 (33%), Positives = 134/275 (48%), Gaps = 43/275 (15%)

Query: 1749 RAGIEGPLLASDVGRDRS---AASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKK 1805
            R+    P  A D  R RS   A     S  P +A + S     +     K +D       
Sbjct: 413  RSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPN-----KARDHSRSRSP 467

Query: 1806 NKNRDKGEKE---KKRDSSLRSRSKRSKSSEHK-SRKRTSESRSRARKRSSKSKSHRSQT 1861
            NK RD+       K+RD S       SK  +H+ SR  + E + R  + SSK + HR   
Sbjct: 468  NKARDRSRSRSPSKERDHS--QLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR--- 522

Query: 1862 RSRSRSR-RRRRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKT 1917
            RSRS S+ R+RR SRS +K R R   RS S+E+  R  +  SK R+R+R RS S++  + 
Sbjct: 523  RSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERR 582

Query: 1918 VRARSRTPSRRSRSHTPSRR---RRSRSVGRRRSFSISPSRRSRTPSR-----RSRTPSR 1969
                S      SRS +P+++    R R+  + ++ S     RSRTPS+     +SRT S+
Sbjct: 583  QSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHS-----RSRTPSKEGNHSQSRTSSK 637

Query: 1970 RSRTPSRRS--RTPSRRSRTPSRRS-----RTPSR 1997
             S  PS+ +  R+P  + R+P+R S     RTPS+
Sbjct: 638  ES-DPSQSTVPRSPDWK-RSPTRTSSLSQNRTPSK 670



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 74/240 (30%), Positives = 111/240 (46%), Gaps = 19/240 (7%)

Query: 1755 PLLASDVGRDRS---AASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRD- 1810
            P  A D  R RS   A     S  P +A + S       E     +D  +    +K RD 
Sbjct: 443  PYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKE-----RDHSQLGSPSKERDH 497

Query: 1811 KGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR 1870
            +  +   ++   R     SK  +H+  +  S+ R R + RS   +  RSQ+RS S  R  
Sbjct: 498  RRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREH 557

Query: 1871 RRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR 1927
            R+ SRS SK R R   RS SKE+ +R  +  S+ R+  R RS ++ +  +    S     
Sbjct: 558  RQ-SRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKA 616

Query: 1928 RSRSHTPSRRRRSRSVGRRRSFSISPSRRS--RTPSRRSRTPSRRSRTPSRRSRTPSRRS 1985
             SRS TPS +  + S  R  S    PS+ +  R+P  + R+P+R S     ++RTPS+ S
Sbjct: 617  HSRSRTPS-KEGNHSQSRTSSKESDPSQSTVPRSPDWK-RSPTRTSSL--SQNRTPSKTS 672



 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 71/246 (28%), Positives = 116/246 (47%), Gaps = 16/246 (6%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            RD S +     +     S S S+E+D  ++    K+   +  ++ ++++  ++ +  S  
Sbjct: 459  RDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKE 518

Query: 1823 RS-RSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR-RRSSRSRSKS 1880
            R  R  RS S E + R+  S ++ R R +S      R   +SRS S+ R RR  RS SK 
Sbjct: 519  RDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKE 578

Query: 1881 RGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR 1937
            R R   RS S+E+     +  +K     R R+SS++      +RSRTPS+   +H+ SR 
Sbjct: 579  RERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEK---AHSRSRTPSKEG-NHSQSRT 634

Query: 1938 RRSRSVGRRRSFSISPSRRSRTPSRRS-----RTPSR-RSRTPSRRSRTPSRRSRTPSRR 1991
                S   + +   SP  + R+P+R S     RTPS+  S +PS         S+  S+ 
Sbjct: 635  SSKESDPSQSTVPRSPDWK-RSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQA 693

Query: 1992 SRTPSR 1997
              T S+
Sbjct: 694  DATTSK 699



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 64/216 (29%), Positives = 100/216 (46%), Gaps = 15/216 (6%)

Query: 1778 RASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSR 1837
            R S SSS+E+D        + +   SK+ + R      K+RD S +SRS  S+  EH+  
Sbjct: 510  RQSRSSSKERDH-------RRSRSPSKERQRRQSRSPNKERDRS-QSRSP-SEEREHRQS 560

Query: 1838 KRTSESRSRARKRSSKSKSHRSQTRSRSRSR--RRRRSSRSRSKSRGRRSVSKEKRKRSP 1895
            +  S+ R R R RS   +  R Q+RS S  R   R RS   +S     R+ SKEK     
Sbjct: 561  RSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAHSRS 620

Query: 1896 KHRSKSRERKRKRSSSRDNRKTVRARSRTPS-RRSRSHTPSRRRRSRSVGRRRSFSISPS 1954
            +  SK     + R+SS+++  +     R+P  +RS + T S    S++    ++ S SPS
Sbjct: 621  RTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS---LSQNRTPSKTSSHSPS 677

Query: 1955 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR 1990
                     S+  S+   T S+ +    R S + S+
Sbjct: 678  TFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSK 713



 Score = 58.9 bits (141), Expect = 6e-08
 Identities = 80/313 (25%), Positives = 127/313 (40%), Gaps = 47/313 (15%)

Query: 1763 RDRSAASPVVSSMPERASESS------SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEK 1816
            +   +A+P  S +P + + S       S  K       K   ++  S +++ R K     
Sbjct: 33   KSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPS 92

Query: 1817 KRDSSLRSRSKRSKSSEHKS-RKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSR 1875
            +  +  R+ SK SK+S+ +  ++R + SR R   R     S RS +R+ +  R R   +R
Sbjct: 93   RVSTDTRT-SKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGAR 151

Query: 1876 SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPS 1935
                SR R   S++K  R  K   + R   R+RS S+               R+ S    
Sbjct: 152  PGMASRVRTPTSQQKGSRG-KSYGRPRTSNRERSDSQP--------------RNLSKKSY 196

Query: 1936 RRRRSRSVGRRRSFSISPS-RRSRTPS-----RRSRTPSRRSR----------TPSR-RS 1978
            R      +GR    +++PS  + +TP+      +S  PS  S            PSR +S
Sbjct: 197  RPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKS 256

Query: 1979 RTPSRRS------RTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSP 2032
             +P+  S         S RSR P    +SRS  R RS S      R      +R  SR+ 
Sbjct: 257  YSPTEMSSRVKSYNQASTRSR-PQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRAR 315

Query: 2033 IRRKRSRSSERGR 2045
             R ++   S+ GR
Sbjct: 316  SRTRKGILSQMGR 328



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 75/274 (27%), Positives = 114/274 (41%), Gaps = 48/274 (17%)

Query: 1815 EKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRS-SKSKSHRSQTRSRSRSRRRRRS 1873
            + K  +SL+S      ++ ++S   T  + SR    S S SKS +S +  R+ S R    
Sbjct: 25   DPKPPASLKSTKS---ATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSR 81

Query: 1874 SRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDN---RKTVRARSRTPSRRSR 1930
            SR RSK+R    VS + R       S  R  +R+ + SR     R+  R+  R+PSR S 
Sbjct: 82   SRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPSRAS- 140

Query: 1931 SHTPSRRR----------------------RSRSVGRRRSFSISPS-RRSRTPSRRSRTP 1967
              TP R R                      R +S GR R+ +   S  + R  S++S  P
Sbjct: 141  --TPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRP 198

Query: 1968 ---------SRRSRTPS-RRSRTPSRRSRTPSRRSRTPSRRRRSRS----VVRRRSFSIS 2013
                     S  + TPS  + +TP+         + +PS  R+ +S    ++  R  S S
Sbjct: 199  PGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYS 258

Query: 2014 PVRLRRSRTPLRRRFSRS-PIRRKRSRSSERGRS 2046
            P  +        +  +RS P    +SRS  R RS
Sbjct: 259  PTEMSSRVKSYNQASTRSRPQSHSQSRSPRRSRS 292


>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
          Length = 330

 Score =  108 bits (270), Expect = 6e-23
 Identities = 79/180 (43%), Positives = 100/180 (55%), Gaps = 14/180 (7%)

Query: 1781 ESSSEEKDDYEIFVKVK-------DTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSE 1833
            ES  EE+D+ E   K K       D  + SK N +  + E   K+ S+ RSRSK S+SS 
Sbjct: 152  ESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSK-SRSSH 210

Query: 1834 HKSRKRTSE---SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRR-SVSKE 1889
             +S  R+S    SRSR+R RS  S S +S++RS SR R R R S+SRS SR  R S S  
Sbjct: 211  SRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPR 270

Query: 1890 KRKRSPKHRSKSRERK--RKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRR 1947
            KR  S    S  R RK  R RSSS  +RK  R RSR+P RR RS + S    SRS  +++
Sbjct: 271  KRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSKKK 330



 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 71/198 (35%), Positives = 98/198 (49%), Gaps = 24/198 (12%)

Query: 1796 VKDTHEKSKKNKNRDKGE--------KEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRA 1847
            +K+  +K  + +  D+ E        +++  D +  S+     S E  S K+ S  RSR+
Sbjct: 145  LKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRS 204

Query: 1848 RKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRK 1907
            + RSS S   RS +RS S S     SSRSRS+SR R S S + R RS      SRER R 
Sbjct: 205  KSRSSHS---RSSSRSSSPS-----SSRSRSRSRSRSSSSSQSRSRS-----SSRERSRS 251

Query: 1908 RSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTP 1967
            R S   +       S +P +RS S + S   R+R   R RS S    ++ RT   RSR+P
Sbjct: 252  RGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRT---RSRSP 308

Query: 1968 SRRSRTPSRRSRTPSRRS 1985
             RR R+ S  S + SR S
Sbjct: 309  ERRHRSSSGSSHSGSRSS 326



 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 58/147 (39%), Positives = 77/147 (52%), Gaps = 8/147 (5%)

Query: 1899 SKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSR 1958
            S+  +  +K+S+ R   K+  + SR+ SR S   +PS  R SRS  R RS S S SR   
Sbjct: 188  SEEEDSNKKKSNRRSRSKSRSSHSRSSSRSS---SPSSSR-SRSRSRSRSSSSSQSRSRS 243

Query: 1959 TPSRRSRTPSRRSRTPSRRSR-TPSRRSRTPSRRSRTPSR-RRRSRSVVRRRSFSISPVR 2016
            +   RSR+   +SR+ SR  R + S R R+ S  S +P R R+RSRS  R  S      R
Sbjct: 244  SSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRS--RSSSSGDRKKR 301

Query: 2017 LRRSRTPLRRRFSRSPIRRKRSRSSER 2043
              RSR+P RR  S S      SRSS +
Sbjct: 302  RTRSRSPERRHRSSSGSSHSGSRSSSK 328



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 56/142 (39%), Positives = 75/142 (52%), Gaps = 9/142 (6%)

Query: 1899 SKSRERKRKRSSSRDNRKTVRARSRTPSR-RSRSHTPSRRRRSRSVGRRRSFSISPSR-R 1956
            +K +  +R RS SR +     +RS +PS  RSRS     R RSRS    +S S S SR R
Sbjct: 194  NKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRS-----RSRSRSSSSSQSRSRSSSRER 248

Query: 1957 SRTPSRRSRTPSRRSR-TPSRRSRTPSRRSRTPSR-RSRTPSRRRRSRSVVRRRSFSISP 2014
            SR+   +SR+ SR  R + S R R+ S  S +P R R R+ SR   S    +RR+ S SP
Sbjct: 249  SRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSP 308

Query: 2015 VRLRRSRTPLRRRFSRSPIRRK 2036
             R  RS +      SRS  ++K
Sbjct: 309  ERRHRSSSGSSHSGSRSSSKKK 330



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 51/161 (31%), Positives = 71/161 (44%), Gaps = 14/161 (8%)

Query: 1760 DVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRD 1819
            D   D   A     ++     E S+++K +     K + +H +S    +     + + R 
Sbjct: 170  DEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRS 229

Query: 1820 SSLRSRSKRSKS---SEHKSRKRTSESRSRAR---------KRSSKSKSHRSQTRSRSRS 1867
             S  S S +S+S   S  +SR R S+SRS +R         KRS  S S  S  R+R RS
Sbjct: 230  RSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSS-SSPERNRKRS 288

Query: 1868 RRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKR 1908
            R R  SS  R K R  RS S E+R RS    S S  R   +
Sbjct: 289  RSRSSSSGDRKKRR-TRSRSPERRHRSSSGSSHSGSRSSSK 328



 Score = 57.4 bits (137), Expect = 2e-07
 Identities = 54/192 (28%), Positives = 76/192 (39%), Gaps = 12/192 (6%)

Query: 1699 KESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLA 1758
            KES G E++      +   D       ED ++ADL +  L    E  ++ +         
Sbjct: 151  KESEGEEEDEDEDLSKYKLDED-----EDEDDADLSKYNLDASEEEDSNKKKSNRRSRSK 205

Query: 1759 SDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKR 1818
            S     RS++     S     S S S      +           S + ++R +G K +  
Sbjct: 206  SRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQ------SRSRSSSRERSRSRGSKSRSS 259

Query: 1819 DSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRS 1878
              S R  S   K S   S      +R R+R RSS S   R + R+RSRS  RR  S S S
Sbjct: 260  SRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSS-SSGDRKKRRTRSRSPERRHRSSSGS 318

Query: 1879 KSRGRRSVSKEK 1890
               G RS SK+K
Sbjct: 319  SHSGSRSSSKKK 330


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score =  107 bits (268), Expect = 1e-22
 Identities = 88/281 (31%), Positives = 125/281 (44%), Gaps = 26/281 (9%)

Query: 1772 VSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKS 1831
            VS  P R +E             KVKD    SK+   R   EK+ K  + ++ R+K    
Sbjct: 412  VSESPNRKNEKEK----------KVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSR 461

Query: 1832 SEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKR 1891
            S+ K + ++ E  S+  +   K    RS+ R     + + + S S+ K +  RS SKEK 
Sbjct: 462  SKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQ-ERSRSKEKS 520

Query: 1892 KRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSI 1951
            K+     SKS E    +S  +D R   R+R    ++   S+    R RSRS  R RS  +
Sbjct: 521  KQL---ESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRS--RDRSRRV 575

Query: 1952 SPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRR---SRSVVRRR 2008
                  R  SR       R +   RR R+ SR  RTP  RSR+  RRRR   SRS  R  
Sbjct: 576  RSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREE 635

Query: 2009 SFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKR 2049
            S S       R++   R + S+S  R++ S S +R  S  R
Sbjct: 636  SQS-------RNKDKYRNQESKSSHRKENSESEKRMYSKSR 669



 Score = 92.0 bits (227), Expect = 6e-18
 Identities = 88/286 (30%), Positives = 135/286 (47%), Gaps = 39/286 (13%)

Query: 1773 SSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSS--------LRS 1824
            S+  ER    +SE+ D Y+   KVK   +   ++K+++K  K K+RDS         +RS
Sbjct: 431  SNSKERDIRRNSEKDDKYKN--KVKKRAKSKSRSKSKEKS-KSKERDSKHNRNEEKRMRS 487

Query: 1825 RSKRSKSSEHKSRKRTSESRSRARKRS-SKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGR 1883
            RSK       K +++ S+S+ + ++RS SK KS + +++S      + +    R++SR R
Sbjct: 488  RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547

Query: 1884 R-SVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR-RSRSHTPSRRRRSR 1941
               ++K K      + S++RER R R  SR      R RSRT  R RSRS    R R   
Sbjct: 548  ECDITKGKHS----YNSRTRERSRSRDRSR------RVRSRTHDRDRSRSKEYHRYREQE 597

Query: 1942 SVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRS 2001
               R R    S SR  RTP  RSR+  RR R   RR    S R  + S R++   R + S
Sbjct: 598  YRRRGR----SRSRERRTPPGRSRSKDRRRR---RRDSRSSEREESQS-RNKDKYRNQES 649

Query: 2002 RSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSP 2047
            +S  R+ +         +SR         +     R + ++R +SP
Sbjct: 650  KSSHRKENSESEKRMYSKSR-------DHNSSNNSREKKADRDQSP 688



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 71/261 (27%), Positives = 119/261 (45%), Gaps = 25/261 (9%)

Query: 1773 SSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRD-KGEKEKKRDSSLRSRSKRSKS 1831
            S   ER S+ +  E+       K +D     +K K  D KG+ +++  S  +S+   SKS
Sbjct: 468  SKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKS 527

Query: 1832 SEH-----KSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRG---- 1882
            +EH     K + R ++SRSR    +    S+ S+TR RSRSR R R  RSR+  R     
Sbjct: 528  NEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRS 587

Query: 1883 ------------RRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSR 1930
                        RR  S+ + +R+P  RS+S++R+R+R  SR + +   ++SR   +   
Sbjct: 588  KEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSERE-ESQSRNKDKYRN 646

Query: 1931 SHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR 1990
              + S  R+  S   +R +S S    S   SR  +  + R ++P  + +  S+ +   S 
Sbjct: 647  QESKSSHRKENSESEKRMYSKSRDHNSSNNSREKK--ADRDQSPFSKIKQSSQDNELKSS 704

Query: 1991 RSRTPSRRRRSRSVVRRRSFS 2011
              +     +   SV +    S
Sbjct: 705  MLKNKEDEKIRSSVEKENQKS 725



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 85/339 (25%), Positives = 137/339 (40%), Gaps = 26/339 (7%)

Query: 1802 KSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQT 1861
            KSK  K   K  K     SS  S S  S  S+  S    SES +  + +  K K  ++  
Sbjct: 180  KSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSR 239

Query: 1862 RSRSRSRRRRRSSRSRS--------KSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSS-R 1912
            + +   ++R++S +S S        +++ + +V  E+    P++R   R+   K     R
Sbjct: 240  KHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKER 299

Query: 1913 DNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSR-RSRTPSRRS 1971
             NR+  R R   P     S   S +RR       R       RR RTPSR RSR   RRS
Sbjct: 300  KNRERERERECNPPN---SQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRS 356

Query: 1972 RTPS--RRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFS 2029
             TP   R+    ++R R  S        +     +   +    SPVR++  +    R  S
Sbjct: 357  ETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQR---SPVRVKERKITDHRNVS 413

Query: 2030 RSPIRR-------KRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLK 2082
             SP R+       K  +S+ + R  +R ++ D     ++ K   +   +K+        +
Sbjct: 414  ESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKER 473

Query: 2083 PAPPPTIEEK-VAKKSGGATIEELTEKCKQIAQSKEDDD 2120
             +     EEK +  +S G   E + EK KQ     +D +
Sbjct: 474  DSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQE 512



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 81/344 (23%), Positives = 146/344 (42%), Gaps = 53/344 (15%)

Query: 1766 SAASPVVSSMPERASES-SSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRS 1824
            S++S   SS  + +S+S SS +  D E   + K    K K  KN  K +KEKK+    R 
Sbjct: 194  SSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKK----RK 249

Query: 1825 RSKRSKSSEHKSRKRTSESRSRAR-------------KRSSKSKSHRSQTRSRSRSR--- 1868
            +SK+S SSE ++    ++ +S  R              R S  K+   + ++R R R   
Sbjct: 250  KSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERE 309

Query: 1869 ------------RRRRSSRSRSKSRGR-----------RSVSKEKRKRSPKHRSKSRERK 1905
                        RR   +RS  K +GR           RS  + +R  +P H  +  +R 
Sbjct: 310  CNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRA 369

Query: 1906 RKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSR-RS 1964
            ++   S   R     +S     +    +P  R + R +   R+ S SP+R++    + + 
Sbjct: 370  QRMRVSSGERWIKGDKSELNEIKENQRSPV-RVKERKITDHRNVSESPNRKNEKEKKVKD 428

Query: 1965 RTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR---RRRSRSVVRRRSFSISPVRLRRSR 2021
               + + R   R S    +      +R+++ SR   + +S+S  R    + +  +  RSR
Sbjct: 429  HKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSR 488

Query: 2022 TPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAKAN 2065
            +  R       ++ K  +S  +G+  +R    +K++ LE +K+N
Sbjct: 489  SKGR---DHENVKEKEKQSDSKGKDQERSRSKEKSKQLE-SKSN 528



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 95/343 (27%), Positives = 144/343 (41%), Gaps = 87/343 (25%)

Query: 1801 EKSKKNKNRDKGEKEKKRDSS---------LRSRSKRSKSSEHKSRKRT-SESRSRARKR 1850
            EK +KN+ R++ E+E    +S         L +RS R        R RT S SRSR R R
Sbjct: 296  EKERKNRERER-ERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFR 354

Query: 1851 SSKSKSHRSQTRSRSRSRR-------------------RRRSSRSRSKSR---GRRSVSK 1888
             S++  H  Q   R++  R                     + S  R K R     R+VS+
Sbjct: 355  RSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSE 414

Query: 1889 ------EKRKRSPKHRSKSRERKRKRSSSRDN------RKTVRARSRTPSRR-------- 1928
                  EK K+   H+S S+ER  +R+S +D+      +K  +++SR+ S+         
Sbjct: 415  SPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERD 474

Query: 1929 -SRSHTPSRRRRSRSVGR-----RRSFSISPSR-----RSRTPSRRSRTPSRRSRTPSRR 1977
               +    +R RSRS GR     +     S S+     RSR+  +  +  S+ +     +
Sbjct: 475  SKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSK 534

Query: 1978 SRTPSRRSRTPSR-------------------RSRTPSRRRRSRSVVRRRSFSISPVRLR 2018
            S+   RR+++ SR                   RSR  SRR RSR+  R RS S    R R
Sbjct: 535  SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYR 594

Query: 2019 ----RSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQ 2057
                R R   R R  R+P  R RS+   R R   R ++ +++Q
Sbjct: 595  EQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQ 637



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 56/179 (31%), Positives = 81/179 (45%), Gaps = 15/179 (8%)

Query: 1760 DVGRDRSAA-SPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKR 1818
            D  R RS   S  + S       S S+EKD        +    K K + N    E+ + R
Sbjct: 510  DQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSR 569

Query: 1819 DSSLRSRSKRSKS-------SEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRR 1871
            D   RSR  RS++       S+   R R  E R R R RS + ++   ++RS+ R RRRR
Sbjct: 570  D---RSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDR-RRRR 625

Query: 1872 RSSRS--RSKSRGRRSVSKEKRKRSPKHRSKSRE-RKRKRSSSRDNRKTVRARSRTPSR 1927
            R SRS  R +S+ R       ++    HR ++ E  KR  S SRD+  +  +R +   R
Sbjct: 626  RDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADR 684



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 42/174 (24%), Positives = 71/174 (40%), Gaps = 10/174 (5%)

Query: 1774 SMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKR----- 1828
            S   R  E S        +  +  D      K  +R + E+E +R    RSR +R     
Sbjct: 557  SYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYR-EQEYRRRGRSRSRERRTPPGR 615

Query: 1829 SKSSEHKSRKRTSESRSRARKRS-SKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVS 1887
            S+S + + R+R S S  R   +S +K K    +++S  R        R  SKSR   S +
Sbjct: 616  SRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSN 675

Query: 1888 KEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSR 1941
              + K++ + +S   + K+   SS+DN             + RS      ++S+
Sbjct: 676  NSREKKADRDQSPFSKIKQ---SSQDNELKSSMLKNKEDEKIRSSVEKENQKSK 726



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 34/119 (28%), Positives = 55/119 (46%), Gaps = 7/119 (5%)

Query: 1799 THEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHR 1858
            +  K ++ + RD    E++   S      R++ S+   RK  SES  R     SKS+ H 
Sbjct: 616  SRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKR---MYSKSRDHN 672

Query: 1859 SQTRSRSRSRRRRRSSRSRSKSRGRRSVSKE---KRKRSPKHRSKSRERKRKRSSSRDN 1914
            S   SR +   R +S  S+ K   + +  K    K K   K RS S E++ ++S  ++N
Sbjct: 673  SSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRS-SVEKENQKSKGQEN 730



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 40/171 (23%), Positives = 65/171 (38%), Gaps = 28/171 (16%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            R R   S        R+ E     + +Y    + +    ++   ++R K  + ++RDS  
Sbjct: 571  RSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDS-- 628

Query: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSS--------KSKSHRSQTRSRSRSRRRRRSS 1874
            RS  +    S +K + R  ES+S  RK +S        KS+ H S   SR +   R +S 
Sbjct: 629  RSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSP 688

Query: 1875 RSRSKSRG------------------RRSVSKEKRKRSPKHRSKSRERKRK 1907
             S+ K                     R SV KE +K   +      E+ +K
Sbjct: 689  FSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739



 Score = 42.0 bits (97), Expect = 0.007
 Identities = 26/122 (21%), Positives = 57/122 (46%), Gaps = 1/122 (0%)

Query: 1778 RASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSR 1837
            R  +S S E+++ +   K K  +++SK +  ++  E EK+  S  R  +  + S E K+ 
Sbjct: 624  RRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKA- 682

Query: 1838 KRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKH 1897
             R     S+ ++ S  ++   S  +++   + R    +   KS+G+ +    ++ +   H
Sbjct: 683  DRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDH 742

Query: 1898 RS 1899
             S
Sbjct: 743  ES 744



 Score = 41.2 bits (95), Expect = 0.012
 Identities = 21/58 (36%), Positives = 32/58 (55%)

Query: 82  DLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESK 139
           D    S+ S   S     T+E   K+ KKH+K+  K KK+KK+++K  K    ESE++
Sbjct: 205 DSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAE 262



 Score = 40.4 bits (93), Expect = 0.020
 Identities = 63/278 (22%), Positives = 109/278 (39%), Gaps = 52/278 (18%)

Query: 1895 PKHRSKSRERKRKR------SSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRS 1948
            PK + K  E+KR +      SSS D+  +  ++S + S  S S T  + ++ +   R+ S
Sbjct: 179  PKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNS 238

Query: 1949 FSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTP-------------------S 1989
                  ++ R  S++S +    +     + ++  R    P                    
Sbjct: 239  RKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKE 298

Query: 1990 RRSRTPSRRR------------RSRSVVRRRSFSISPVRLRRSRTPLRR----RFSRS-- 2031
            R++R   R R            + R +V R    I     RR RTP R     RF RS  
Sbjct: 299  RKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSET 358

Query: 2032 -PIRRKRSRSSERGR--SPKRLTDLDKAQLLEIAKANAAAMCAK-AGVPLPPNLKPAPPP 2087
             P  R+  + ++R R  S +R    DK++L EI +   + +  K   +    N+  +P  
Sbjct: 359  PPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNR 418

Query: 2088 TIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNK 2125
              E++   K   +  +E     + I ++ E DD   NK
Sbjct: 419  KNEKEKKVKDHKSNSKE-----RDIRRNSEKDDKYKNK 451



 Score = 35.4 bits (80), Expect = 0.65
 Identities = 20/67 (29%), Positives = 32/67 (47%)

Query: 106 KKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAV 165
           K S+KHKK K K+KK KK    + + +  E++ ++    +    +  + FL   S P A 
Sbjct: 236 KNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKAD 295

Query: 166 ALELPTR 172
             E   R
Sbjct: 296 EKERKNR 302



 Score = 35.4 bits (80), Expect = 0.65
 Identities = 25/80 (31%), Positives = 42/80 (52%), Gaps = 6/80 (7%)

Query: 79  YKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEE-SE 137
           +K + KE  R  R  S + D       K++K   + K+K+K K KE++ K+ R  E+   
Sbjct: 429 HKSNSKE--RDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMR 486

Query: 138 SKTKSHDDGNI---DLESDS 154
           S++K  D  N+   + +SDS
Sbjct: 487 SRSKGRDHENVKEKEKQSDS 506



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 17/51 (33%), Positives = 31/51 (60%), Gaps = 2/51 (3%)

Query: 94  SVQTDPTDEIPTKKSKKHKK--HKNKKKKKKKEKEKKYKRQPEESESKTKS 142
           S  +  ++    +KSKK KK   KN +K KK++K++K  ++   SES+ ++
Sbjct: 213 SSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAEN 263



 Score = 31.6 bits (70), Expect = 9.4
 Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 14/128 (10%)

Query: 44  NQAGDAA----ASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDP 99
           NQ  DAA    A  R L   E++ K     S V   E +        S  S      +D 
Sbjct: 156 NQKTDAASKPFAEVRILSCGELIPK-----SKVKKEEKKRHKSSSSSSSSSSDSDSSSDS 210

Query: 100 TDEIPTKKSKKHKKHKNKKKKKK----KEKEKKYKRQPEESESKTKSHDDG-NIDLESDS 154
                +  S+   + K+KK+KKK      K KK K++ ++S+    S  +  N++ +  S
Sbjct: 211 QSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQS 270

Query: 155 FLKFDSEP 162
            ++ +  P
Sbjct: 271 TVRPEEIP 278


>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
          Length = 2812

 Score =  107 bits (267), Expect = 1e-22
 Identities = 95/372 (25%), Positives = 172/372 (46%), Gaps = 56/372 (15%)

Query: 1141 TEAYMVP---PLPPEEPPTM----PPLPPEEPPM---TPPLPPEE----------PPEGP 1180
            TE   VP   P  P E PT+    P +P E+P M    P +P E+          P E P
Sbjct: 581  TEKPTVPKEKPTIPTEKPTISTEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKP 640

Query: 1181 ALPTEQSALTAEN-TWPTEVPSSPSEESVSQPEPPVSQSE----ISEPSAVPTDYSVSAS 1235
             +P+E+  ++ E  T PTE P++P+EE+ +  E PV  +E     +E  ++PT+    + 
Sbjct: 641  TIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKPSIPTEKPTISM 700

Query: 1236 DPSVLVSEAAVTVPEPPPEPESSITL-------------TPVESAVV-AEEHEVVPERPV 1281
            + +++ +E     PE P  P    T+             TP E   +  E+  + PE+P 
Sbjct: 701  EETIISTEKPTISPEKPTIPTEKPTIPTEKSTISPEKPTTPTEKPTIPTEKPTISPEKPT 760

Query: 1282 TCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAE 1341
            T   +E P +S E   + +E P +     T  + + +  +++E  T+   P   T +  E
Sbjct: 761  T--PTEKPTISPEKLTIPTEKPTIPTEKPTIPTEKPT--ISTEEPTT---PTEETTISTE 813

Query: 1342 SILEPPAMAAPESSAMAVLESSAVTVLESSTVTV-LESSTVTVLEPSVVTVPEPPVVAEP 1400
                P  M  P         S   T + +  +T+ +E  T++  +P++ T  E P ++ P
Sbjct: 814  KPSIP--MEKPTLPTEETTTSVEETTISTEKLTIPMEKPTISTEKPTIPT--EKPTIS-P 868

Query: 1401 DYVTIPVP--VVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQT 1458
            + +TIP     +   +P++P+ E  +S  + ++   +P++S ++ T++  +P +   + T
Sbjct: 869  EKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEKPTISPEKPTISTEKPTIPTEKPT 928

Query: 1459 QVIPTEVAIEST 1470
              IPTE    ST
Sbjct: 929  --IPTEETTIST 938



 Score =  100 bits (249), Expect = 2e-20
 Identities = 84/347 (24%), Positives = 146/347 (42%), Gaps = 51/347 (14%)

Query: 1145 MVPPLPPEEP---------------PTMPPLPPE---EPPMTPPLPPEEPPEGPALPTEQ 1186
            ++P LPP  P               PT+    P    E P      P  P E P +PTE+
Sbjct: 538  VLPELPPVSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTEKPTVPKEKPTIPTEK 597

Query: 1187 SALTAEN-TWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAA 1245
              ++ E  T P+E P+ PSE+     E P   + ++E   +P++     S+   + +E  
Sbjct: 598  PTISTEKPTIPSEKPNMPSEKPTIPSEKP---TILTEKPTIPSEKPTIPSEKPTISTEKP 654

Query: 1246 VTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVM 1305
                E P  P    T +  E  +  E+  +  E+P   + +E P +S E T++++E P +
Sbjct: 655  TVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKP--SIPTEKPTISMEETIISTEKPTI 712

Query: 1306 SETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAV 1365
            S    T  + +               P + T    +S + P     P        E   +
Sbjct: 713  SPEKPTIPTEK---------------PTIPT---EKSTISPEKPTTPTEKPTIPTEKPTI 754

Query: 1366 TVLESSTVTVLESSTVTVLEPSVVTVP--EPPVVAEPDYVTIPVPVVSALEPSVPVLEPA 1423
            +  + +T T  E  T++   P  +T+P  +P +  E   +    P +S  EP+ P  E  
Sbjct: 755  SPEKPTTPT--EKPTIS---PEKLTIPTEKPTIPTEKPTIPTEKPTISTEEPTTPTEETT 809

Query: 1424 VSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIEST 1470
            +S  +PS+ + +P++  +E+T +V E   T+S +   IP E    ST
Sbjct: 810  ISTEKPSIPMEKPTLPTEETTTSVEE--TTISTEKLTIPMEKPTIST 854



 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 85/373 (22%), Positives = 158/373 (42%), Gaps = 47/373 (12%)

Query: 1137 TDTYTEAYMVPPLPPEEPPTMPPLPPEEP-------------PMTPPLPPEEPPEGPALP 1183
            T T  E  ++P   P  P   P +P E+P             P   P  P  P E P +P
Sbjct: 668  TTTSMEEPVIPTEKPSIPTEKPSIPTEKPTISMEETIISTEKPTISPEKPTIPTEKPTIP 727

Query: 1184 TEQSALTAEN-TWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVS 1242
            TE+S ++ E  T PTE P+ P+E+    PE P + +E  +P+  P   ++    P++   
Sbjct: 728  TEKSTISPEKPTTPTEKPTIPTEKPTISPEKPTTPTE--KPTISPEKLTIPTEKPTIPTE 785

Query: 1243 EAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVP-ERP------VTCMVSETPAMSAEP 1295
            +   T+P   P   +    TP E   ++ E   +P E+P       T  V ET  +S E 
Sbjct: 786  KP--TIPTEKPTISTEEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEET-TISTEK 842

Query: 1296 TVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESS 1355
              +  E P +S    T  + + +    S    ++    +T P       E P +   E++
Sbjct: 843  LTIPMEKPTISTEKPTIPTEKPT---ISPEKLTIPTEKLTIPT------EKPTIPIEETT 893

Query: 1356 AMAVLESSAVTVLESSTVTVLESSTVTVLEPSV----VTVPEPPVVAEPDYVTIPV--PV 1409
                + +  +T+         E  T++  +P++     T+P        + +TIP   P 
Sbjct: 894  ----ISTEKLTIPTEKPTISPEKPTISTEKPTIPTEKPTIPTEETTISTEKLTIPTEKPT 949

Query: 1410 VSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIES 1469
            +S  + ++P  +P +S  +P++   + ++  ++ T+   +P +   + T + P   +  +
Sbjct: 950  ISPEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPPHPSPTA 1009

Query: 1470 TPMILESSIMSSH 1482
            T   L + +MS H
Sbjct: 1010 TG--LAALVMSPH 1020



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 77/339 (22%), Positives = 135/339 (39%), Gaps = 50/339 (14%)

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEP---PEGPALPTEQSALTAEN--------TWP 1196
            P  P E  T+ P  P  P   P +P E+P   PE P  PTE+  ++ E         T P
Sbjct: 724  PTIPTEKSTISPEKPTTPTEKPTIPTEKPTISPEKPTTPTEKPTISPEKLTIPTEKPTIP 783

Query: 1197 TEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPE 1256
            TE P+ P+E+     E P + +E         + ++S   PS         +P   P   
Sbjct: 784  TEKPTIPTEKPTISTEEPTTPTE---------ETTISTEKPS---------IPMEKPTLP 825

Query: 1257 SSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMR 1316
            +  T T VE   ++ E   +P         E P +S E   + +E P +S    T  + +
Sbjct: 826  TEETTTSVEETTISTEKLTIP--------MEKPTISTEKPTIPTEKPTISPEKLTIPTEK 877

Query: 1317 ASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVL 1376
             +  + +E  T   +P   T +  E +  P            +         E  T+   
Sbjct: 878  LT--IPTEKPT---IPIEETTISTEKLTIPTEKPTISPEKPTISTEKPTIPTEKPTIPTE 932

Query: 1377 ESSTVTVLEPSVVTVPEPPVVAEPDYVTIPV--PVVSALEPSVPVLEPAVSVLQPSMIVS 1434
            E    T +    +T+P       P+ +TIP   P +S  +P++P  +  +   +P++   
Sbjct: 933  E----TTISTEKLTIPTEKPTISPEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTE 988

Query: 1435 EPSVSVQEST-VTVSEPAVTVSEQTQVIPTEVAIESTPM 1472
            +P++  ++ T +    P+ T +    ++ +  A  STPM
Sbjct: 989  KPTIPTEKLTALRPPHPSPTATGLAALVMSPHA-PSTPM 1026



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 105/467 (22%), Positives = 176/467 (37%), Gaps = 108/467 (23%)

Query: 170 PTRAFGPSETN---ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQS 226
           P  + GPSET    E+P +  + P VS+E          KP+  T + +V          
Sbjct: 547 PVSSTGPSETTGLTENPTISTKKPTVSIE----------KPSVTTEKPTV---------- 586

Query: 227 EQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEP 286
                  P+   T          +PT    + + +P +        K  + S + T P  
Sbjct: 587 -------PKEKPT----------IPTEKPTISTEKPTIPSE-----KPNMPSEKPTIPSE 624

Query: 287 SKIMLVEPPVA---KVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQP 343
              +L E P     K   PSE   +S+E PT    EP+T T          E     E+P
Sbjct: 625 KPTILTEKPTIPSEKPTIPSEKPTISTEKPTVPTEEPTTPTE---------ETTTSMEEP 675

Query: 344 VDVPSEIADSSMTRPQELPELP-KTTALELQESSVASAMELPGPPATSMPELQGPPVTPV 402
           V +P+E      + P E P +P +   + ++E+ +++      P   ++P       T  
Sbjct: 676 V-IPTE----KPSIPTEKPSIPTEKPTISMEETIISTEKPTISPEKPTIP-------TEK 723

Query: 403 LELPGPSATPVPELPGPLSTPVPELPGPPATAVPELP-----GPSVTP--------VPQL 449
             +P   +T  PE P    T  P +P    T  PE P      P+++P         P +
Sbjct: 724 PTIPTEKSTISPEKP-TTPTEKPTIPTEKPTISPEKPTTPTEKPTISPEKLTIPTEKPTI 782

Query: 450 SQELPGLPA--PSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQP 507
             E P +P   P++  E P    E   ++ E P +P+     E P  P       + E  
Sbjct: 783 PTEKPTIPTEKPTISTEEPTTPTEETTISTEKPSIPM-----EKPTLPTEETTTSVEETT 837

Query: 508 VTTTELEQPVGMTTV--EHPGHP---------EVTTATGLLGQPEATMVLELPGQPVATT 556
           ++T +L  P+   T+  E P  P         ++T  T  L  P     + +    ++T 
Sbjct: 838 ISTEKLTIPMEKPTISTEKPTIPTEKPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTE 897

Query: 557 ALELPGQ-PSV-----TGVPELPGLPSATRALELSGQPVATGALELP 597
            L +P + P++     T   E P +P+    +      ++T  L +P
Sbjct: 898 KLTIPTEKPTISPEKPTISTEKPTIPTEKPTIPTEETTISTEKLTIP 944



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 113/451 (25%), Positives = 182/451 (40%), Gaps = 56/451 (12%)

Query: 160  SEPSAVALELPT-RAFGPSETNESPAVVLEPPVVSMEV----SEPHILETLKPATKTAEL 214
            +E   ++ E PT  +  P+  +E P +  E P +  E     SE   + + KP   T E 
Sbjct: 595  TEKPTISTEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKPTIPSEKPTIST-EK 653

Query: 215  SVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKS 274
              V T   +  +E++   M EP +     S     +PT    + + +P ++M      ++
Sbjct: 654  PTVPTEEPTTPTEETTTSMEEPVIPTEKPS-----IPTEKPSIPTEKPTISME-----ET 703

Query: 275  VLKSVEST-SPEPSKIMLVEPPVA---------KVLEPSETLVVSSETPTEVYPEPSTST 324
            ++ + + T SPE   I   +P +          K   P+E   + +E PT + PE  T+ 
Sbjct: 704  IISTEKPTISPEKPTIPTEKPTIPTEKSTISPEKPTTPTEKPTIPTEKPT-ISPEKPTTP 762

Query: 325  TMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKT----TALELQESSVASA 380
            T + P  S  E L +P +   +P+E       +P    E P T    T +  ++ S+   
Sbjct: 763  T-EKPTISP-EKLTIPTEKPTIPTEKPTIPTEKPTISTEEPTTPTEETTISTEKPSIP-- 818

Query: 381  MELPGPPA----TSMPE--LQGPPVTPVLELPGPSATPVPELPGPLSTPVPE---LPGPP 431
            ME P  P     TS+ E  +    +T  +E P  S T  P +P    T  PE   +P   
Sbjct: 819  MEKPTLPTEETTTSVEETTISTEKLTIPMEKPTIS-TEKPTIPTEKPTISPEKLTIPTEK 877

Query: 432  ATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVEL 491
             T   E P     P+ + +     L  P+   E P   PE P ++ E P +P     +  
Sbjct: 878  LTIPTEKP---TIPIEETTISTEKLTIPT---EKPTISPEKPTISTEKPTIPTEKPTIPT 931

Query: 492  PEQPAVTVAMEL-TEQPVTTTE-LEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELP 549
             E    T  + + TE+P  + E L  P    T+     P + T    +   + T+  E P
Sbjct: 932  EETTISTEKLTIPTEKPTISPEKLTIPTEKPTIS-TEKPTIPTEKLTIPTEKPTIPTEKP 990

Query: 550  GQPV-ATTALELP-GQPSVTGVPELPGLPSA 578
              P    TAL  P   P+ TG+  L   P A
Sbjct: 991  TIPTEKLTALRPPHPSPTATGLAALVMSPHA 1021



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 43/165 (26%), Positives = 74/165 (44%), Gaps = 20/165 (12%)

Query: 1137 TDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAEN-TW 1195
            T   TE   +P   P   P  P +  E+P +        P E P +PTE++ ++ E  T 
Sbjct: 892  TTISTEKLTIPTEKPTISPEKPTISTEKPTI--------PTEKPTIPTEETTISTEKLTI 943

Query: 1196 PTEVPS-SPSEESVSQPEPPVSQSEISEPS---AVPTDYSVSASDPSVLVSEAAVTVPEP 1251
            PTE P+ SP + ++   +P +S  + + P+    +PT+     ++   + +E    +  P
Sbjct: 944  PTEKPTISPEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPP 1003

Query: 1252 PPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPT 1296
             P P    T T + +A+V   H   P  P+T ++  T   S   T
Sbjct: 1004 HPSP----TATGL-AALVMSPH--APSTPMTSVILGTTTTSRSST 1041



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 83/364 (22%), Positives = 139/364 (38%), Gaps = 48/364 (13%)

Query: 55   SLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDE--IPTKKSKKHK 112
            S+P E+    +EE    ++ TE   KP +             T PT++  IPT+KS    
Sbjct: 690  SIPTEKPTISMEET---IISTE---KPTISPEK--------PTIPTEKPTIPTEKSTISP 735

Query: 113  KHKNKKKKKKKEKEKKYKRQPEE----SESKTKSHDDGNIDLESDSFLKFDSEPSAVALE 168
            +      +K     +K    PE+    +E  T S +   I  E  +     +E   +  E
Sbjct: 736  EKPTTPTEKPTIPTEKPTISPEKPTTPTEKPTISPEKLTIPTEKPTI---PTEKPTIPTE 792

Query: 169  LPTRAFG-PSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSE 227
             PT +   P+   E   +  E P + ME       ET    T + E + +ST  ++   E
Sbjct: 793  KPTISTEEPTTPTEETTISTEKPSIPMEKPTLPTEET----TTSVEETTISTEKLTIPME 848

Query: 228  QSVAVMPEPSMT--KILDSFAAAPVPTTTLVLKSSEPVVTM---SVEYQMKSVLKSVEST 282
            +      +P++   K   S     +PT  L + + +P + +   ++  +  ++     + 
Sbjct: 849  KPTISTEKPTIPTEKPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEKPTI 908

Query: 283  SPEPSKIMLVEP--PVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLP 340
            SPE   I   +P  P  K   P+E   +S+E  T    +P+ S           E L +P
Sbjct: 909  SPEKPTISTEKPTIPTEKPTIPTEETTISTEKLTIPTEKPTISP----------EKLTIP 958

Query: 341  EQPVDVPSE---IADSSMTRPQELPELPKTTALELQESSVASAMELPGPPATSMPELQGP 397
             +   + +E   I    +T P E P +P        E   A     P P AT +  L   
Sbjct: 959  TEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPPHPSPTATGLAALVMS 1018

Query: 398  PVTP 401
            P  P
Sbjct: 1019 PHAP 1022



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 41/192 (21%), Positives = 84/192 (43%), Gaps = 21/192 (10%)

Query: 1280 PVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTT--P 1337
            P TC V   P +     V ++ P   SET    ++   S     + + S+  P+VTT  P
Sbjct: 531  PGTCPVKVLPELPPVSPVSSTGP---SETTGLTENPTIS---TKKPTVSIEKPSVTTEKP 584

Query: 1338 VLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVV 1397
             + +   E P +   + +    + +   T+         E  T+   +P+++T  +P + 
Sbjct: 585  TVPK---EKPTIPTEKPT----ISTEKPTIPSEKPNMPSEKPTIPSEKPTILT-EKPTIP 636

Query: 1398 AEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAV----- 1452
            +E   +    P +S  +P+VP  EP     + +  + EP +  ++ ++   +P++     
Sbjct: 637  SEKPTIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKPSIPTEKP 696

Query: 1453 TVSEQTQVIPTE 1464
            T+S +  +I TE
Sbjct: 697  TISMEETIISTE 708



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 50/190 (26%), Positives = 79/190 (41%), Gaps = 24/190 (12%)

Query: 416 LPGPLSTPVPELPGPPATAVPELPGPS----VTPVPQLSQELP--GLPAPSMGLEPPQEV 469
           L  P + PV  LP  P  +     GPS    +T  P +S + P   +  PS+  E P   
Sbjct: 528 LINPGTCPVKVLPELPPVSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTEKPTVP 587

Query: 470 PEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHP---- 525
            E P +  E P     T + E P  P+    M  +E+P  T   E+P  +T  E P    
Sbjct: 588 KEKPTIPTEKP-----TISTEKPTIPSEKPNMP-SEKP--TIPSEKPTILT--EKPTIPS 637

Query: 526 GHPEVTTATGLLGQPEATMVLELPGQPV--ATTALELPGQPS-VTGVP-ELPGLPSATRA 581
             P + +    +   + T+  E P  P    TT++E P  P+    +P E P +P+    
Sbjct: 638 EKPTIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKPSIPTEKPT 697

Query: 582 LELSGQPVAT 591
           + +    ++T
Sbjct: 698 ISMEETIIST 707


>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
          Length = 2721

 Score =  107 bits (267), Expect = 1e-22
 Identities = 95/372 (25%), Positives = 172/372 (46%), Gaps = 56/372 (15%)

Query: 1141 TEAYMVP---PLPPEEPPTM----PPLPPEEPPM---TPPLPPEE----------PPEGP 1180
            TE   VP   P  P E PT+    P +P E+P M    P +P E+          P E P
Sbjct: 581  TEKPTVPKEKPTIPTEKPTISTEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKP 640

Query: 1181 ALPTEQSALTAEN-TWPTEVPSSPSEESVSQPEPPVSQSE----ISEPSAVPTDYSVSAS 1235
             +P+E+  ++ E  T PTE P++P+EE+ +  E PV  +E     +E  ++PT+    + 
Sbjct: 641  TIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKPSIPTEKPTISM 700

Query: 1236 DPSVLVSEAAVTVPEPPPEPESSITL-------------TPVESAVV-AEEHEVVPERPV 1281
            + +++ +E     PE P  P    T+             TP E   +  E+  + PE+P 
Sbjct: 701  EETIISTEKPTISPEKPTIPTEKPTIPTEKSTISPEKPTTPTEKPTIPTEKPTISPEKPT 760

Query: 1282 TCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAE 1341
            T   +E P +S E   + +E P +     T  + + +  +++E  T+   P   T +  E
Sbjct: 761  T--PTEKPTISPEKLTIPTEKPTIPTEKPTIPTEKPT--ISTEEPTT---PTEETTISTE 813

Query: 1342 SILEPPAMAAPESSAMAVLESSAVTVLESSTVTV-LESSTVTVLEPSVVTVPEPPVVAEP 1400
                P  M  P         S   T + +  +T+ +E  T++  +P++ T  E P ++ P
Sbjct: 814  KPSIP--MEKPTLPTEETTTSVEETTISTEKLTIPMEKPTISTEKPTIPT--EKPTIS-P 868

Query: 1401 DYVTIPVP--VVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQT 1458
            + +TIP     +   +P++P+ E  +S  + ++   +P++S ++ T++  +P +   + T
Sbjct: 869  EKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEKPTISPEKPTISTEKPTIPTEKPT 928

Query: 1459 QVIPTEVAIEST 1470
              IPTE    ST
Sbjct: 929  --IPTEETTIST 938



 Score =  100 bits (249), Expect = 2e-20
 Identities = 84/347 (24%), Positives = 146/347 (42%), Gaps = 51/347 (14%)

Query: 1145 MVPPLPPEEP---------------PTMPPLPPE---EPPMTPPLPPEEPPEGPALPTEQ 1186
            ++P LPP  P               PT+    P    E P      P  P E P +PTE+
Sbjct: 538  VLPELPPVSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTEKPTVPKEKPTIPTEK 597

Query: 1187 SALTAEN-TWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAA 1245
              ++ E  T P+E P+ PSE+     E P   + ++E   +P++     S+   + +E  
Sbjct: 598  PTISTEKPTIPSEKPNMPSEKPTIPSEKP---TILTEKPTIPSEKPTIPSEKPTISTEKP 654

Query: 1246 VTVPEPPPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVM 1305
                E P  P    T +  E  +  E+  +  E+P   + +E P +S E T++++E P +
Sbjct: 655  TVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKP--SIPTEKPTISMEETIISTEKPTI 712

Query: 1306 SETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAV 1365
            S    T  + +               P + T    +S + P     P        E   +
Sbjct: 713  SPEKPTIPTEK---------------PTIPT---EKSTISPEKPTTPTEKPTIPTEKPTI 754

Query: 1366 TVLESSTVTVLESSTVTVLEPSVVTVP--EPPVVAEPDYVTIPVPVVSALEPSVPVLEPA 1423
            +  + +T T  E  T++   P  +T+P  +P +  E   +    P +S  EP+ P  E  
Sbjct: 755  SPEKPTTPT--EKPTIS---PEKLTIPTEKPTIPTEKPTIPTEKPTISTEEPTTPTEETT 809

Query: 1424 VSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIEST 1470
            +S  +PS+ + +P++  +E+T +V E   T+S +   IP E    ST
Sbjct: 810  ISTEKPSIPMEKPTLPTEETTTSVEE--TTISTEKLTIPMEKPTIST 854



 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 85/373 (22%), Positives = 158/373 (42%), Gaps = 47/373 (12%)

Query: 1137 TDTYTEAYMVPPLPPEEPPTMPPLPPEEP-------------PMTPPLPPEEPPEGPALP 1183
            T T  E  ++P   P  P   P +P E+P             P   P  P  P E P +P
Sbjct: 668  TTTSMEEPVIPTEKPSIPTEKPSIPTEKPTISMEETIISTEKPTISPEKPTIPTEKPTIP 727

Query: 1184 TEQSALTAEN-TWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVS 1242
            TE+S ++ E  T PTE P+ P+E+    PE P + +E  +P+  P   ++    P++   
Sbjct: 728  TEKSTISPEKPTTPTEKPTIPTEKPTISPEKPTTPTE--KPTISPEKLTIPTEKPTIPTE 785

Query: 1243 EAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVP-ERP------VTCMVSETPAMSAEP 1295
            +   T+P   P   +    TP E   ++ E   +P E+P       T  V ET  +S E 
Sbjct: 786  KP--TIPTEKPTISTEEPTTPTEETTISTEKPSIPMEKPTLPTEETTTSVEET-TISTEK 842

Query: 1296 TVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESS 1355
              +  E P +S    T  + + +    S    ++    +T P       E P +   E++
Sbjct: 843  LTIPMEKPTISTEKPTIPTEKPT---ISPEKLTIPTEKLTIPT------EKPTIPIEETT 893

Query: 1356 AMAVLESSAVTVLESSTVTVLESSTVTVLEPSV----VTVPEPPVVAEPDYVTIPV--PV 1409
                + +  +T+         E  T++  +P++     T+P        + +TIP   P 
Sbjct: 894  ----ISTEKLTIPTEKPTISPEKPTISTEKPTIPTEKPTIPTEETTISTEKLTIPTEKPT 949

Query: 1410 VSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIES 1469
            +S  + ++P  +P +S  +P++   + ++  ++ T+   +P +   + T + P   +  +
Sbjct: 950  ISPEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPPHPSPTA 1009

Query: 1470 TPMILESSIMSSH 1482
            T   L + +MS H
Sbjct: 1010 TG--LAALVMSPH 1020



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 77/339 (22%), Positives = 135/339 (39%), Gaps = 50/339 (14%)

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEP---PEGPALPTEQSALTAEN--------TWP 1196
            P  P E  T+ P  P  P   P +P E+P   PE P  PTE+  ++ E         T P
Sbjct: 724  PTIPTEKSTISPEKPTTPTEKPTIPTEKPTISPEKPTTPTEKPTISPEKLTIPTEKPTIP 783

Query: 1197 TEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPE 1256
            TE P+ P+E+     E P + +E         + ++S   PS         +P   P   
Sbjct: 784  TEKPTIPTEKPTISTEEPTTPTE---------ETTISTEKPS---------IPMEKPTLP 825

Query: 1257 SSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMR 1316
            +  T T VE   ++ E   +P         E P +S E   + +E P +S    T  + +
Sbjct: 826  TEETTTSVEETTISTEKLTIP--------MEKPTISTEKPTIPTEKPTISPEKLTIPTEK 877

Query: 1317 ASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVL 1376
             +  + +E  T   +P   T +  E +  P            +         E  T+   
Sbjct: 878  LT--IPTEKPT---IPIEETTISTEKLTIPTEKPTISPEKPTISTEKPTIPTEKPTIPTE 932

Query: 1377 ESSTVTVLEPSVVTVPEPPVVAEPDYVTIPV--PVVSALEPSVPVLEPAVSVLQPSMIVS 1434
            E    T +    +T+P       P+ +TIP   P +S  +P++P  +  +   +P++   
Sbjct: 933  E----TTISTEKLTIPTEKPTISPEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTE 988

Query: 1435 EPSVSVQEST-VTVSEPAVTVSEQTQVIPTEVAIESTPM 1472
            +P++  ++ T +    P+ T +    ++ +  A  STPM
Sbjct: 989  KPTIPTEKLTALRPPHPSPTATGLAALVMSPHA-PSTPM 1026



 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 105/467 (22%), Positives = 176/467 (37%), Gaps = 108/467 (23%)

Query: 170 PTRAFGPSETN---ESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQS 226
           P  + GPSET    E+P +  + P VS+E          KP+  T + +V          
Sbjct: 547 PVSSTGPSETTGLTENPTISTKKPTVSIE----------KPSVTTEKPTV---------- 586

Query: 227 EQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEP 286
                  P+   T          +PT    + + +P +        K  + S + T P  
Sbjct: 587 -------PKEKPT----------IPTEKPTISTEKPTIPSE-----KPNMPSEKPTIPSE 624

Query: 287 SKIMLVEPPVA---KVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQP 343
              +L E P     K   PSE   +S+E PT    EP+T T          E     E+P
Sbjct: 625 KPTILTEKPTIPSEKPTIPSEKPTISTEKPTVPTEEPTTPTE---------ETTTSMEEP 675

Query: 344 VDVPSEIADSSMTRPQELPELP-KTTALELQESSVASAMELPGPPATSMPELQGPPVTPV 402
           V +P+E      + P E P +P +   + ++E+ +++      P   ++P       T  
Sbjct: 676 V-IPTE----KPSIPTEKPSIPTEKPTISMEETIISTEKPTISPEKPTIP-------TEK 723

Query: 403 LELPGPSATPVPELPGPLSTPVPELPGPPATAVPELP-----GPSVTP--------VPQL 449
             +P   +T  PE P    T  P +P    T  PE P      P+++P         P +
Sbjct: 724 PTIPTEKSTISPEKP-TTPTEKPTIPTEKPTISPEKPTTPTEKPTISPEKLTIPTEKPTI 782

Query: 450 SQELPGLPA--PSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQP 507
             E P +P   P++  E P    E   ++ E P +P+     E P  P       + E  
Sbjct: 783 PTEKPTIPTEKPTISTEEPTTPTEETTISTEKPSIPM-----EKPTLPTEETTTSVEETT 837

Query: 508 VTTTELEQPVGMTTV--EHPGHP---------EVTTATGLLGQPEATMVLELPGQPVATT 556
           ++T +L  P+   T+  E P  P         ++T  T  L  P     + +    ++T 
Sbjct: 838 ISTEKLTIPMEKPTISTEKPTIPTEKPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTE 897

Query: 557 ALELPGQ-PSV-----TGVPELPGLPSATRALELSGQPVATGALELP 597
            L +P + P++     T   E P +P+    +      ++T  L +P
Sbjct: 898 KLTIPTEKPTISPEKPTISTEKPTIPTEKPTIPTEETTISTEKLTIP 944



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 113/451 (25%), Positives = 182/451 (40%), Gaps = 56/451 (12%)

Query: 160  SEPSAVALELPT-RAFGPSETNESPAVVLEPPVVSMEV----SEPHILETLKPATKTAEL 214
            +E   ++ E PT  +  P+  +E P +  E P +  E     SE   + + KP   T E 
Sbjct: 595  TEKPTISTEKPTIPSEKPNMPSEKPTIPSEKPTILTEKPTIPSEKPTIPSEKPTIST-EK 653

Query: 215  SVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKS 274
              V T   +  +E++   M EP +     S     +PT    + + +P ++M      ++
Sbjct: 654  PTVPTEEPTTPTEETTTSMEEPVIPTEKPS-----IPTEKPSIPTEKPTISME-----ET 703

Query: 275  VLKSVEST-SPEPSKIMLVEPPVA---------KVLEPSETLVVSSETPTEVYPEPSTST 324
            ++ + + T SPE   I   +P +          K   P+E   + +E PT + PE  T+ 
Sbjct: 704  IISTEKPTISPEKPTIPTEKPTIPTEKSTISPEKPTTPTEKPTIPTEKPT-ISPEKPTTP 762

Query: 325  TMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKT----TALELQESSVASA 380
            T + P  S  E L +P +   +P+E       +P    E P T    T +  ++ S+   
Sbjct: 763  T-EKPTISP-EKLTIPTEKPTIPTEKPTIPTEKPTISTEEPTTPTEETTISTEKPSIP-- 818

Query: 381  MELPGPPA----TSMPE--LQGPPVTPVLELPGPSATPVPELPGPLSTPVPE---LPGPP 431
            ME P  P     TS+ E  +    +T  +E P  S T  P +P    T  PE   +P   
Sbjct: 819  MEKPTLPTEETTTSVEETTISTEKLTIPMEKPTIS-TEKPTIPTEKPTISPEKLTIPTEK 877

Query: 432  ATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVEL 491
             T   E P     P+ + +     L  P+   E P   PE P ++ E P +P     +  
Sbjct: 878  LTIPTEKP---TIPIEETTISTEKLTIPT---EKPTISPEKPTISTEKPTIPTEKPTIPT 931

Query: 492  PEQPAVTVAMEL-TEQPVTTTE-LEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELP 549
             E    T  + + TE+P  + E L  P    T+     P + T    +   + T+  E P
Sbjct: 932  EETTISTEKLTIPTEKPTISPEKLTIPTEKPTIS-TEKPTIPTEKLTIPTEKPTIPTEKP 990

Query: 550  GQPV-ATTALELP-GQPSVTGVPELPGLPSA 578
              P    TAL  P   P+ TG+  L   P A
Sbjct: 991  TIPTEKLTALRPPHPSPTATGLAALVMSPHA 1021



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 43/165 (26%), Positives = 74/165 (44%), Gaps = 20/165 (12%)

Query: 1137 TDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAEN-TW 1195
            T   TE   +P   P   P  P +  E+P +        P E P +PTE++ ++ E  T 
Sbjct: 892  TTISTEKLTIPTEKPTISPEKPTISTEKPTI--------PTEKPTIPTEETTISTEKLTI 943

Query: 1196 PTEVPS-SPSEESVSQPEPPVSQSEISEPS---AVPTDYSVSASDPSVLVSEAAVTVPEP 1251
            PTE P+ SP + ++   +P +S  + + P+    +PT+     ++   + +E    +  P
Sbjct: 944  PTEKPTISPEKLTIPTEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPP 1003

Query: 1252 PPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPT 1296
             P P    T T + +A+V   H   P  P+T ++  T   S   T
Sbjct: 1004 HPSP----TATGL-AALVMSPH--APSTPMTSVILGTTTTSRSST 1041



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 83/364 (22%), Positives = 139/364 (38%), Gaps = 48/364 (13%)

Query: 55   SLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDE--IPTKKSKKHK 112
            S+P E+    +EE    ++ TE   KP +             T PT++  IPT+KS    
Sbjct: 690  SIPTEKPTISMEET---IISTE---KPTISPEK--------PTIPTEKPTIPTEKSTISP 735

Query: 113  KHKNKKKKKKKEKEKKYKRQPEE----SESKTKSHDDGNIDLESDSFLKFDSEPSAVALE 168
            +      +K     +K    PE+    +E  T S +   I  E  +     +E   +  E
Sbjct: 736  EKPTTPTEKPTIPTEKPTISPEKPTTPTEKPTISPEKLTIPTEKPTI---PTEKPTIPTE 792

Query: 169  LPTRAFG-PSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISEQSE 227
             PT +   P+   E   +  E P + ME       ET    T + E + +ST  ++   E
Sbjct: 793  KPTISTEEPTTPTEETTISTEKPSIPMEKPTLPTEET----TTSVEETTISTEKLTIPME 848

Query: 228  QSVAVMPEPSMT--KILDSFAAAPVPTTTLVLKSSEPVVTM---SVEYQMKSVLKSVEST 282
            +      +P++   K   S     +PT  L + + +P + +   ++  +  ++     + 
Sbjct: 849  KPTISTEKPTIPTEKPTISPEKLTIPTEKLTIPTEKPTIPIEETTISTEKLTIPTEKPTI 908

Query: 283  SPEPSKIMLVEP--PVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLP 340
            SPE   I   +P  P  K   P+E   +S+E  T    +P+ S           E L +P
Sbjct: 909  SPEKPTISTEKPTIPTEKPTIPTEETTISTEKLTIPTEKPTISP----------EKLTIP 958

Query: 341  EQPVDVPSE---IADSSMTRPQELPELPKTTALELQESSVASAMELPGPPATSMPELQGP 397
             +   + +E   I    +T P E P +P        E   A     P P AT +  L   
Sbjct: 959  TEKPTISTEKPTIPTEKLTIPTEKPTIPTEKPTIPTEKLTALRPPHPSPTATGLAALVMS 1018

Query: 398  PVTP 401
            P  P
Sbjct: 1019 PHAP 1022



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 41/192 (21%), Positives = 84/192 (43%), Gaps = 21/192 (10%)

Query: 1280 PVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTT--P 1337
            P TC V   P +     V ++ P   SET    ++   S     + + S+  P+VTT  P
Sbjct: 531  PGTCPVKVLPELPPVSPVSSTGP---SETTGLTENPTIS---TKKPTVSIEKPSVTTEKP 584

Query: 1338 VLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVV 1397
             + +   E P +   + +    + +   T+         E  T+   +P+++T  +P + 
Sbjct: 585  TVPK---EKPTIPTEKPT----ISTEKPTIPSEKPNMPSEKPTIPSEKPTILT-EKPTIP 636

Query: 1398 AEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAV----- 1452
            +E   +    P +S  +P+VP  EP     + +  + EP +  ++ ++   +P++     
Sbjct: 637  SEKPTIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKPSIPTEKP 696

Query: 1453 TVSEQTQVIPTE 1464
            T+S +  +I TE
Sbjct: 697  TISMEETIISTE 708



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 50/190 (26%), Positives = 79/190 (41%), Gaps = 24/190 (12%)

Query: 416 LPGPLSTPVPELPGPPATAVPELPGPS----VTPVPQLSQELP--GLPAPSMGLEPPQEV 469
           L  P + PV  LP  P  +     GPS    +T  P +S + P   +  PS+  E P   
Sbjct: 528 LINPGTCPVKVLPELPPVSPVSSTGPSETTGLTENPTISTKKPTVSIEKPSVTTEKPTVP 587

Query: 470 PEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHP---- 525
            E P +  E P     T + E P  P+    M  +E+P  T   E+P  +T  E P    
Sbjct: 588 KEKPTIPTEKP-----TISTEKPTIPSEKPNMP-SEKP--TIPSEKPTILT--EKPTIPS 637

Query: 526 GHPEVTTATGLLGQPEATMVLELPGQPV--ATTALELPGQPS-VTGVP-ELPGLPSATRA 581
             P + +    +   + T+  E P  P    TT++E P  P+    +P E P +P+    
Sbjct: 638 EKPTIPSEKPTISTEKPTVPTEEPTTPTEETTTSMEEPVIPTEKPSIPTEKPSIPTEKPT 697

Query: 582 LELSGQPVAT 591
           + +    ++T
Sbjct: 698 ISMEETIIST 707


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score =  105 bits (263), Expect = 4e-22
 Identities = 122/363 (33%), Positives = 168/363 (46%), Gaps = 58/363 (15%)

Query: 1725 IEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSS 1784
            IE ++ +D+ R L     E+L           L  D    R   S   S    R+   S 
Sbjct: 145  IEFVSYSDMKRAL-----EKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSR 199

Query: 1785 EEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRD-SSLRSRSKRSKS---SEHKSRKRT 1840
              +         K +H KS+         + K R  S  RSRSK+ KS   S+ KSR R+
Sbjct: 200  HSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRS 259

Query: 1841 ---SESRSRARKRSS------------KSKS---HRSQTRSRSRSRRRRRSSRSR-SKSR 1881
                +SRS+++ ++             KS+S   H+S+++SRSRS+ RR     R S SR
Sbjct: 260  HSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSR 319

Query: 1882 GRRSVSKEKRKRSPKHRSK----SRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR 1937
            GR   S+EK  R  + RS+    SR R R RS S+D RK  R RSR  S RSRS + S+ 
Sbjct: 320  GR---SQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKG-RKRSREES-RSRSRSRSKS 374

Query: 1938 RRSRSVGRRRSFSISPSRRSR---TPSRRSRTPSR---------RSRTPSRRSRTPSRRS 1985
             RSR  G +R      S++ +   T   +SR+PSR         +S +  R  R  S  +
Sbjct: 375  ERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENA 434

Query: 1986 RTPSR---RSRTPSRRRRS-RSVVRRRSFSISPVRLR-RSRTPLRRRFSRSPIRRKRSRS 2040
             T      RSR+ S+ + +  S  R RS S S  R R +SR+   R  SRSP  R RSRS
Sbjct: 435  GTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRS---RSASRSP-SRSRSRS 490

Query: 2041 SER 2043
              R
Sbjct: 491  HSR 493



 Score =  103 bits (258), Expect = 1e-21
 Identities = 88/279 (31%), Positives = 128/279 (45%), Gaps = 28/279 (10%)

Query: 1805 KNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRT-------SESRSRARKRSSKSKSH 1857
            ++++  +     +     RSRS  SKSS  KSR R+       S+SRSR++ R S+SK  
Sbjct: 187  RSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSR-SRSKKE 245

Query: 1858 RSQTRSRSRSRRRRRS---SRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDN 1914
            +S++ S+ +SR R  S   SRS+SK +    +        PK RS SR + + +S SR  
Sbjct: 246  KSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQ 305

Query: 1915 RKTVRARSRTPSRRSRSHTPSRRR---RSRSVG--RRRSFSISPSRRSRTPSRRSRTPSR 1969
             + V    R    R RS   S R+   RSRS G  R RS S S S+  R   +RSR  SR
Sbjct: 306  ERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESR 365

Query: 1970 -RSRTPSRRSRTPSRRSRTPSRRSRTPSRRRR----------SRSVVRRRSFSISPVRLR 2018
             RSR+ S+  R+  R S+  S+   +  +++           SRSV + R  + S    R
Sbjct: 366  SRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQR 425

Query: 2019 RSRTPLRRRFSRSPIR-RKRSRSSERGRSPKRLTDLDKA 2056
              R       +    R R RS S  +   P       K+
Sbjct: 426  EGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKS 464



 Score = 94.7 bits (234), Expect = 9e-19
 Identities = 95/288 (32%), Positives = 134/288 (46%), Gaps = 38/288 (13%)

Query: 1794 VKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRK-RTSESRSRARKRSS 1852
            V   D H K +KN+    G  E    S ++   ++   +E   RK R  E +  +R+R S
Sbjct: 130  VTYADAH-KGRKNE----GVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRS 184

Query: 1853 KSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSR 1912
             S+S     RS SRSR R R SR +S+SR   S S   + RS + RS SR R + RS S+
Sbjct: 185  YSRS-----RSHSRSRSRSRHSR-KSRSRSGSSKSSHSKSRS-RSRSGSRSRSKSRSRSQ 237

Query: 1913 DNRKTVRARSRTPSR---RSRSHTPSRRR------------RSRSVGRRRSFSISPSRRS 1957
               ++ + +SR+PS+   RSRSH+  + R             + +VG+ +  S SPSR  
Sbjct: 238  SRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK--SRSPSRHK 295

Query: 1958 RTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRR---RSRSVVRRRSFSISP 2014
                 RSR+  RR     R S +  R      R+SR+ SR +   RSRS  R +S     
Sbjct: 296  SKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRK 355

Query: 2015 VRLRRSRTPLRRRFSRSPIRRKRSRSSER-----GRSPKRLTDLDKAQ 2057
             R R       R  SRS   R R R S+R         K+  D D++Q
Sbjct: 356  GRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQ 403



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 55/147 (37%), Positives = 79/147 (53%), Gaps = 17/147 (11%)

Query: 1805 KNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSR 1864
            K+K++ KG K  + +S  RSRS RSKS   + R    +S++ + K+  K  + RSQ+RS 
Sbjct: 349  KSKDKRKGRKRSREESRSRSRS-RSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSP 407

Query: 1865 SRS----RRRRRSSRSRSKSRGR----------RSVSKEKRKRSPKHRSKSRERKRKRSS 1910
            SRS    R   +S  S+ + RG           RS S+   K  P   S+SR R +  S 
Sbjct: 408  SRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASK 467

Query: 1911 SRDNRKT-VRARSRTPSR-RSRSHTPS 1935
            +R   K+  R+ SR+PSR RSRSH+ S
Sbjct: 468  TRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 18/60 (30%), Positives = 29/60 (48%)

Query: 84  KEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSH 143
           K    +SR  S     ++    + SK+  K  + KKKKK++ ++   R P  S SK + H
Sbjct: 358 KRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREH 417


>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
            sapiens]
          Length = 434

 Score =  104 bits (260), Expect = 9e-22
 Identities = 101/348 (29%), Positives = 159/348 (45%), Gaps = 46/348 (13%)

Query: 1756 LLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKE 1815
            + ASD  RD  A        PE+ S    ++K+  E+ V  + +     ++++R +   E
Sbjct: 1    MAASDTERDGLA--------PEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSR---E 49

Query: 1816 KKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSS- 1874
            +KR S    R  RS+S   + R+  S+ +S    +  KS+ H  +  S  + R R  SS 
Sbjct: 50   RKRKSDNEGRKHRSRSRSKEGRRHESKDKS---SKKHKSEEHNDKEHSSDKGRERLNSSE 106

Query: 1875 --------RSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRD-NRKTVRARSRTP 1925
                    + R  SRGR       R RS + R +SR R+RK+S SR   RK  R+RSR  
Sbjct: 107  NGEDRHKRKERKSSRGR----SHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSR-E 161

Query: 1926 SRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRS 1985
             ++SRS +  R+RR RS  R RS       R RT S RSRT S RSR   +R   P R S
Sbjct: 162  RKKSRSRSRERKRRIRSRSRSRS-----RHRHRTRS-RSRTRS-RSRDRKKRIEKPRRFS 214

Query: 1986 RTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGR 2045
            R+ SR    P  R R+ ++  + + +    R ++ +    +       +++ + ++  G 
Sbjct: 215  RSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAATGG 274

Query: 2046 SPKRLTDL---------DKAQLLEIAKANAAAMCAKAGVPLPPNLKPA 2084
            S   +  L           A   ++A   A A+ A+ G+ +P    PA
Sbjct: 275  SVLNVAALLASGTQVTPQIAMAAQMAALQAKAL-AETGIAVPSYYNPA 321


>gi|38146113 arginine/serine-rich coiled-coil 2 isoform b [Homo
            sapiens]
          Length = 375

 Score =  102 bits (255), Expect = 3e-21
 Identities = 75/211 (35%), Positives = 105/211 (49%), Gaps = 30/211 (14%)

Query: 1793 FVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSS 1852
            F+K    HE   K+  + K E+   ++ S     +R  SSE+           R +++  
Sbjct: 7    FLKQGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSEN--------GEDRHKRKER 58

Query: 1853 KSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSR 1912
            KS   RS +RSRSR RR R  SR R KSR R   S+E++    K RS+SRERK+ RS SR
Sbjct: 59   KSSRGRSHSRSRSRERRHRSRSRERKKSRSR---SRERK----KSRSRSRERKKSRSRSR 111

Query: 1913 DNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSR 1972
            + ++ +R+RSR+ SR         R R+RS  R RS       RSR   +R   P R SR
Sbjct: 112  ERKRRIRSRSRSRSR--------HRHRTRSRSRTRS-------RSRDRKKRIEKPRRFSR 156

Query: 1973 TPSRRSRTPSRRSRTPSRRSRTPSRRRRSRS 2003
            + SR    P  R R  +  ++    RR  R+
Sbjct: 157  SLSRTPSPPPFRGRNTAMDAQEALARRLERA 187



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 83/272 (30%), Positives = 125/272 (45%), Gaps = 38/272 (13%)

Query: 1839 RTSESRSRARKRSSKSKS--------HRSQTRSRSRSRRRRRSS---------RSRSKSR 1881
            RT+    + R+  SK KS        H  +  S  + R R  SS         + R  SR
Sbjct: 3    RTNFFLKQGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSR 62

Query: 1882 GRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSR 1941
            GR       R R  +HRS+SRERK+ RS SR+ +K+ R+RSR   ++SRS +  R+RR R
Sbjct: 63   GRS--HSRSRSRERRHRSRSRERKKSRSRSRERKKS-RSRSR-ERKKSRSRSRERKRRIR 118

Query: 1942 SVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRS 2001
            S  R RS       R RT S RSRT S RSR   +R   P R SR+ SR    P  R R+
Sbjct: 119  SRSRSRS-----RHRHRTRS-RSRTRS-RSRDRKKRIEKPRRFSRSLSRTPSPPPFRGRN 171

Query: 2002 RSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDL-------- 2053
             ++  + + +    R ++ +    +       +++ + ++  G S   +  L        
Sbjct: 172  TAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAAATGGSVLNVAALLASGTQVT 231

Query: 2054 -DKAQLLEIAKANAAAMCAKAGVPLPPNLKPA 2084
               A   ++A   A A+ A+ G+ +P    PA
Sbjct: 232  PQIAMAAQMAALQAKAL-AETGIAVPSYYNPA 262



 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 99/327 (30%), Positives = 143/327 (43%), Gaps = 68/327 (20%)

Query: 1814 KEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRS 1873
            K+ +R  S    SK+ KS EH  ++ +S+ + R R  SS++   R +       R+ R+S
Sbjct: 9    KQGRRHESKDKSSKKHKSEEHNDKEHSSD-KGRERLNSSENGEDRHK-------RKERKS 60

Query: 1874 SRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHT 1933
            SR RS SR                 S+SRER R RS SR+ +K+ R+RSR          
Sbjct: 61   SRGRSHSR-----------------SRSRER-RHRSRSRERKKS-RSRSR---------- 91

Query: 1934 PSRRRRSRSVGRRRSFSISPSR-RSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRS 1992
               R++SRS  R R  S S SR R R    RSR+ SR       RSRT   RSR+  R+ 
Sbjct: 92   --ERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRT---RSRSRDRKK 146

Query: 1993 RTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTD 2052
            R    RR SRS+   R+ S  P R R +    +   +R   R +R++  +  R  K + +
Sbjct: 147  RIEKPRRFSRSL--SRTPSPPPFRGRNTAMDAQEALAR---RLERAKKLQEQRE-KEMVE 200

Query: 2053 LDKAQLLEIAKA------NAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGAT----- 2101
              K Q +  A A      N AA+ A      P     A    ++ K   ++G A      
Sbjct: 201  KQKQQEIAAAAATGGSVLNVAALLASGTQVTPQIAMAAQMAALQAKALAETGIAVPSYYN 260

Query: 2102 --------IEELTEKCKQIAQSKEDDD 2120
                      E  +K K + Q K++ D
Sbjct: 261  PAAVNPMKFAEQEKKRKMLWQGKKEGD 287



 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 58/163 (35%), Positives = 80/163 (49%), Gaps = 16/163 (9%)

Query: 1774 SMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSE 1833
            S  + + +  SEE +D E         E+   ++N +   K K+R SS      RS+S E
Sbjct: 16   SKDKSSKKHKSEEHNDKEH--SSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRE 73

Query: 1834 HKSRKRTSE-SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRK 1892
             + R R+ E  +SR+R R  K    RS+ R +SRSR R R  R RS+SR R         
Sbjct: 74   RRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSR--------- 124

Query: 1893 RSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPS 1935
               +HR ++R R R RS SRD +K +    R    RS S TPS
Sbjct: 125  --SRHRHRTRSRSRTRSRSRDRKKRIEKPRR--FSRSLSRTPS 163



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 57/180 (31%), Positives = 92/180 (51%), Gaps = 8/180 (4%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGE-KEKKRDSSLRSRSKRSKSSEHK 1835
            E +S+   E  +  E     +D H++ ++  +R +   + + R+   RSRS+  K S  +
Sbjct: 33   EHSSDKGRERLNSSE---NGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSR 89

Query: 1836 SRKRT-SESRSRARKRS-SKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGR-RSVSKEKRK 1892
            SR+R  S SRSR RK+S S+S+  + + RSRSRSR R R  R+RS+SR R RS  ++KR 
Sbjct: 90   SRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHR-HRTRSRSRTRSRSRDRKKRI 148

Query: 1893 RSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSIS 1952
              P+  S+S  R       R     + A+     R  R+     +R    V +++   I+
Sbjct: 149  EKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIA 208



 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 51/182 (28%), Positives = 82/182 (45%), Gaps = 24/182 (13%)

Query: 1756 LLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKE 1815
            L +S+ G DR       SS     S S S E+            H    + + + +    
Sbjct: 43   LNSSENGEDRHKRKERKSSRGRSHSRSRSRER-----------RHRSRSRERKKSRSRSR 91

Query: 1816 KKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRR----- 1870
            +++ S  RSR ++   S  + RKR   SRSR+R R       RS+TRSRSR R++     
Sbjct: 92   ERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKP 151

Query: 1871 RRSSRSRSKS------RGRRSV--SKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARS 1922
            RR SRS S++      RGR +   ++E   R  +   K +E++ K    +  ++ + A +
Sbjct: 152  RRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQEIAAAA 211

Query: 1923 RT 1924
             T
Sbjct: 212  AT 213


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo
            sapiens]
          Length = 624

 Score =  101 bits (252), Expect = 7e-21
 Identities = 80/248 (32%), Positives = 117/248 (47%), Gaps = 32/248 (12%)

Query: 1819 DSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSR---------- 1868
            +S   +  K  +S  H   K  S S+S +R++ S+SK HRS++ +RSRSR          
Sbjct: 296  ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK-HRSRSHNRSRSRQKDRRRSKSP 354

Query: 1869 -------RRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRK-TVRA 1920
                   R RR SRSRS SR +R  ++EK K   + + K RE++R+R   R+  K   + 
Sbjct: 355  HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 414

Query: 1921 RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSR-----RSRTPS 1975
            + R   R         + R R   +         +       + R   R       R   
Sbjct: 415  KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 474

Query: 1976 RRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRR 2035
            ++SRTP  RS   SRRSR+ SR RR R   R RS S SP   R S+T ++R+ SRSP  R
Sbjct: 475  KKSRTPP-RSYNASRRSRSSSRERRRR---RSRSSSRSP---RTSKT-IKRKSSRSPSPR 526

Query: 2036 KRSRSSER 2043
             R++  ++
Sbjct: 527  SRNKKDKK 534



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 86/325 (26%), Positives = 136/325 (41%), Gaps = 39/325 (12%)

Query: 1768 ASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSK 1827
            A   +S+  E  S  S+E K           +H +SK   +     + K+  S  RSRS 
Sbjct: 285  AQSFISAAIEPESGKSNERKGGRS------RSHTRSKSRSSSKSHSRRKRSQSKHRSRSH 338

Query: 1828 RSKSSEHKSRKRTS---ESRSRAR-KRSSKSKSHRSQTRSRSRSR--------------- 1868
                S  K R+R+    + RS++R +R S+S+SH    R  +R +               
Sbjct: 339  NRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKE 398

Query: 1869 RRRRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTP 1925
            R R   R + K RG+   R   +EK +   K + + RER+++    RD  K         
Sbjct: 399  REREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE 458

Query: 1926 SRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPS--- 1982
              + RS     +R+     R    S + SRRSR+ SR  R   RRSR+ SR  RT     
Sbjct: 459  REKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERR--RRRSRSSSRSPRTSKTIK 516

Query: 1983 -RRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSS 2041
             + SR+PS RSR    ++R      +    IS  R R   T +R+  +    + K  ++S
Sbjct: 517  RKSSRSPSPRSRNKKDKKR-----EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNS 571

Query: 2042 ERGRSPKRLTDLDKAQLLEIAKANA 2066
               +  +   + D +   E+   +A
Sbjct: 572  TSLKEKEHNKEPDSSVSKEVDDKDA 596



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 53/201 (26%), Positives = 82/201 (40%), Gaps = 17/201 (8%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKG-EKEKKRDSSLRSRSKRSKSSEHK 1835
            E+  E    +  D E   + KD  +  +K++ R++  E EK RD        + K  E  
Sbjct: 406  EKEKERGKNKDRDKE---REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 462

Query: 1836 SRKRTSESRSRARKRSSKSKSHRSQTRSRSRSR-RRRRSSRSRSKSRGRRSVSKEKRKRS 1894
              K   E R + +K  +  +S+ +  RSRS SR RRRR SRS S+S       K K  RS
Sbjct: 463  RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 522

Query: 1895 PKHRSKSRERK------------RKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRS 1942
            P  RS++++ K            R+R  S   RK+   R         S +   +  ++ 
Sbjct: 523  PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 582

Query: 1943 VGRRRSFSISPSRRSRTPSRR 1963
                 S  +      RT   +
Sbjct: 583  PDSSVSKEVDDKDAPRTEENK 603



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 40/153 (26%), Positives = 62/153 (40%), Gaps = 3/153 (1%)

Query: 1911 SRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRR 1970
            +  N   V+    TP   ++       +R R      S +I P        +  R+ S  
Sbjct: 254  NHSNNAIVKPPEMTPQAAAKE-LEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHT 312

Query: 1971 SRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSR 2030
                   S++ SRR R+ S+       R RSR   RRR  S SP + R      R+  SR
Sbjct: 313  RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRR--SKSPHKKRSKSRERRKSRSR 370

Query: 2031 SPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAK 2063
            S  R KR  + E+ +  +R+ + D+ +  E  K
Sbjct: 371  SHSRDKRKDTREKIKEKERVKEKDREKEREREK 403



 Score = 35.0 bits (79), Expect = 0.85
 Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 5/72 (6%)

Query: 88  RKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKY---KRQPEESESKTKSHD 144
           R+SR  S     +  I  K S+        KK KK+EKE+ +   +R+ E S S  KS +
Sbjct: 500 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559

Query: 145 --DGNIDLESDS 154
             DG   LE +S
Sbjct: 560 DRDGKEKLEKNS 571



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 16/58 (27%), Positives = 32/58 (55%)

Query: 87  SRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHD 144
           SR+ R    ++   D+    + K  +K + K+K ++KE+E++ +R+ E+   K K  D
Sbjct: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418



 Score = 32.0 bits (71), Expect = 7.2
 Identities = 17/72 (23%), Positives = 36/72 (50%), Gaps = 2/72 (2%)

Query: 74  DTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQP 133
           + E   + + + G  K R    + D   E   +K ++ ++ K  +K + KEKEK+  ++ 
Sbjct: 400 EREKEREKEKERGKNKDRDKEREKDR--EKDKEKDREREREKEHEKDRDKEKEKEQDKEK 457

Query: 134 EESESKTKSHDD 145
           E  + ++K  D+
Sbjct: 458 EREKDRSKEIDE 469



 Score = 31.6 bits (70), Expect = 9.4
 Identities = 18/97 (18%), Positives = 50/97 (51%), Gaps = 6/97 (6%)

Query: 51  ASARSLPNEEIVQKIEEV---LSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKK 107
           A+A+ L  EE+++++ E    +S  ++ E     + K G  +S   S ++  + +  +++
Sbjct: 270 AAAKEL--EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRS-KSRSSSKSHSRR 326

Query: 108 SKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHD 144
            +   KH+++   + + ++K  +R     + ++KS +
Sbjct: 327 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE 363


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [Homo
            sapiens]
          Length = 508

 Score =  101 bits (252), Expect = 7e-21
 Identities = 80/248 (32%), Positives = 117/248 (47%), Gaps = 32/248 (12%)

Query: 1819 DSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSR---------- 1868
            +S   +  K  +S  H   K  S S+S +R++ S+SK HRS++ +RSRSR          
Sbjct: 180  ESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK-HRSRSHNRSRSRQKDRRRSKSP 238

Query: 1869 -------RRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRK-TVRA 1920
                   R RR SRSRS SR +R  ++EK K   + + K RE++R+R   R+  K   + 
Sbjct: 239  HKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKN 298

Query: 1921 RSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSR-----RSRTPS 1975
            + R   R         + R R   +         +       + R   R       R   
Sbjct: 299  KDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKD 358

Query: 1976 RRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRR 2035
            ++SRTP  RS   SRRSR+ SR RR R   R RS S SP   R S+T ++R+ SRSP  R
Sbjct: 359  KKSRTPP-RSYNASRRSRSSSRERRRR---RSRSSSRSP---RTSKT-IKRKSSRSPSPR 410

Query: 2036 KRSRSSER 2043
             R++  ++
Sbjct: 411  SRNKKDKK 418



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 86/325 (26%), Positives = 136/325 (41%), Gaps = 39/325 (12%)

Query: 1768 ASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSK 1827
            A   +S+  E  S  S+E K           +H +SK   +     + K+  S  RSRS 
Sbjct: 169  AQSFISAAIEPESGKSNERKGGRS------RSHTRSKSRSSSKSHSRRKRSQSKHRSRSH 222

Query: 1828 RSKSSEHKSRKRTS---ESRSRAR-KRSSKSKSHRSQTRSRSRSR--------------- 1868
                S  K R+R+    + RS++R +R S+S+SH    R  +R +               
Sbjct: 223  NRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKE 282

Query: 1869 RRRRSSRSRSKSRGR---RSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTP 1925
            R R   R + K RG+   R   +EK +   K + + RER+++    RD  K         
Sbjct: 283  REREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE 342

Query: 1926 SRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPS--- 1982
              + RS     +R+     R    S + SRRSR+ SR  R   RRSR+ SR  RT     
Sbjct: 343  REKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERR--RRRSRSSSRSPRTSKTIK 400

Query: 1983 -RRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSS 2041
             + SR+PS RSR    ++R      +    IS  R R   T +R+  +    + K  ++S
Sbjct: 401  RKSSRSPSPRSRNKKDKKR-----EKERDHISERRERERSTSMRKSSNDRDGKEKLEKNS 455

Query: 2042 ERGRSPKRLTDLDKAQLLEIAKANA 2066
               +  +   + D +   E+   +A
Sbjct: 456  TSLKEKEHNKEPDSSVSKEVDDKDA 480



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 53/201 (26%), Positives = 82/201 (40%), Gaps = 17/201 (8%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKG-EKEKKRDSSLRSRSKRSKSSEHK 1835
            E+  E    +  D E   + KD  +  +K++ R++  E EK RD        + K  E  
Sbjct: 290  EKEKERGKNKDRDKE---REKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKD 346

Query: 1836 SRKRTSESRSRARKRSSKSKSHRSQTRSRSRSR-RRRRSSRSRSKSRGRRSVSKEKRKRS 1894
              K   E R + +K  +  +S+ +  RSRS SR RRRR SRS S+S       K K  RS
Sbjct: 347  RSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRS 406

Query: 1895 PKHRSKSRERK------------RKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRS 1942
            P  RS++++ K            R+R  S   RK+   R         S +   +  ++ 
Sbjct: 407  PSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKE 466

Query: 1943 VGRRRSFSISPSRRSRTPSRR 1963
                 S  +      RT   +
Sbjct: 467  PDSSVSKEVDDKDAPRTEENK 487



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 40/153 (26%), Positives = 62/153 (40%), Gaps = 3/153 (1%)

Query: 1911 SRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRR 1970
            +  N   V+    TP   ++       +R R      S +I P        +  R+ S  
Sbjct: 138  NHSNNAIVKPPEMTPQAAAKE-LEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHT 196

Query: 1971 SRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSR 2030
                   S++ SRR R+ S+       R RSR   RRR  S SP + R      R+  SR
Sbjct: 197  RSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRR--SKSPHKKRSKSRERRKSRSR 254

Query: 2031 SPIRRKRSRSSERGRSPKRLTDLDKAQLLEIAK 2063
            S  R KR  + E+ +  +R+ + D+ +  E  K
Sbjct: 255  SHSRDKRKDTREKIKEKERVKEKDREKEREREK 287



 Score = 35.0 bits (79), Expect = 0.85
 Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 5/72 (6%)

Query: 88  RKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKY---KRQPEESESKTKSHD 144
           R+SR  S     +  I  K S+        KK KK+EKE+ +   +R+ E S S  KS +
Sbjct: 384 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 443

Query: 145 --DGNIDLESDS 154
             DG   LE +S
Sbjct: 444 DRDGKEKLEKNS 455



 Score = 33.1 bits (74), Expect = 3.2
 Identities = 16/58 (27%), Positives = 32/58 (55%)

Query: 87  SRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHD 144
           SR+ R    ++   D+    + K  +K + K+K ++KE+E++ +R+ E+   K K  D
Sbjct: 245 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 302



 Score = 32.0 bits (71), Expect = 7.2
 Identities = 17/72 (23%), Positives = 36/72 (50%), Gaps = 2/72 (2%)

Query: 74  DTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQP 133
           + E   + + + G  K R    + D   E   +K ++ ++ K  +K + KEKEK+  ++ 
Sbjct: 284 EREKEREKEKERGKNKDRDKEREKDR--EKDKEKDREREREKEHEKDRDKEKEKEQDKEK 341

Query: 134 EESESKTKSHDD 145
           E  + ++K  D+
Sbjct: 342 EREKDRSKEIDE 353



 Score = 31.6 bits (70), Expect = 9.4
 Identities = 18/97 (18%), Positives = 50/97 (51%), Gaps = 6/97 (6%)

Query: 51  ASARSLPNEEIVQKIEEV---LSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKK 107
           A+A+ L  EE+++++ E    +S  ++ E     + K G  +S   S ++  + +  +++
Sbjct: 154 AAAKEL--EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRS-KSRSSSKSHSRR 210

Query: 108 SKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHD 144
            +   KH+++   + + ++K  +R     + ++KS +
Sbjct: 211 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRE 247


>gi|46309849 hypothetical protein LOC57035 [Homo sapiens]
          Length = 290

 Score =  101 bits (252), Expect = 7e-21
 Identities = 107/332 (32%), Positives = 146/332 (43%), Gaps = 58/332 (17%)

Query: 1870 RRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRS 1929
            + + S S S+S G   +S   R RS    S+S  R   R SSR             SRRS
Sbjct: 14   QEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSR-------------SRRS 60

Query: 1930 RSHTPSRRRRSRSVGR-RRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR-RSRT 1987
            +S + SRRR  R   R  RS+S     RSR+ SR  R   RR     R  R+PSR RSR+
Sbjct: 61   KSRSRSRRRHQRKYRRYSRSYS-----RSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRS 115

Query: 1988 PSR-RSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRS 2046
             SR RSR  S   R+ ++ R + +          RT      SR    R RSR+  R R+
Sbjct: 116  RSRSRSRGRSYCGRAYAIARGQRY------YGFGRTVYPEEHSR---WRDRSRTRSRSRT 166

Query: 2047 PKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELT 2106
            P RL++ D+ +LLEIAK NAA       + LP +L+  P      +    S      EL+
Sbjct: 167  PFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSSNGAKPELS 226

Query: 2107 EKCKQIAQSKEDDDVIVNKPHVSDEEEEEPPFYHHPFKLSEPKPIFFNLNIAAAKPTPPK 2166
            EK                   V+++    P       K ++ + I F+ N + AKP   K
Sbjct: 227  EK-------------------VTEDGTRNP-----NEKPTQQRSIAFSSNNSVAKPI-QK 261

Query: 2167 SQVTLTKEFPVSSGSQHRKKEADSVYGEWVPV 2198
            S    T+E    S    +KK   S YG W+P+
Sbjct: 262  SAKAATEEASSRSPKIDQKK---SPYGLWIPI 290



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 61/169 (36%), Positives = 77/169 (45%), Gaps = 14/169 (8%)

Query: 1797 KDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKS 1856
            KD+   S+   +     + + R  S  SRS    SS   SR R S+SRSR+R+R  +   
Sbjct: 16   KDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRKYR 75

Query: 1857 HRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSP-KHRSKSRERKRKRSSSRDNR 1915
              S++ SRSRSR R R  R R     RR        RSP ++RS+SR R R R  S   R
Sbjct: 76   RYSRSYSRSRSRSRSRRYRERRYGFTRRYY------RSPSRYRSRSRSRSRSRGRSYCGR 129

Query: 1916 KTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRS 1964
                AR +      R+  P    R R   R RS       RSRTP R S
Sbjct: 130  AYAIARGQRYYGFGRTVYPEEHSRWRDRSRTRS-------RSRTPFRLS 171



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 67/173 (38%), Positives = 87/173 (50%), Gaps = 23/173 (13%)

Query: 1814 KEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSS-KSKSHRSQTRSRSRSRRRRR 1872
            +EK   S+ RS      SS  +SR  +  SRS +R  S   S+S RS++RSRSR R +R+
Sbjct: 14   QEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRK 73

Query: 1873 -------SSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTP 1925
                    SRSRS+SR RR   +        +RS SR R R RS         R+RSR  
Sbjct: 74   YRRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRSRS---------RSRSRGR 124

Query: 1926 SRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRS 1978
            S   R++  +R +R    GR    ++ P   SR    RSRT S RSRTP R S
Sbjct: 125  SYCGRAYAIARGQRYYGFGR----TVYPEEHSRWRD-RSRTRS-RSRTPFRLS 171



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 61/285 (21%), Positives = 109/285 (38%), Gaps = 23/285 (8%)

Query: 1736 PLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASP----VVSSMPERASESSSEEKDDYE 1791
            P  P++ +  ++ R+G    L +    R  S +S     V S    R+  S S  +    
Sbjct: 10   PGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRR 69

Query: 1792 IFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRS 1851
               K +       ++++R +  + ++R      R  RS S  ++SR R   SRSR+R RS
Sbjct: 70   HQRKYRRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPS-RYRSRSR---SRSRSRGRS 125

Query: 1852 SKSKSHRSQTRSR----SRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRK 1907
               +++      R     R+      SR R +SR R       R R+P  R   ++R   
Sbjct: 126  YCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRTR------SRSRTP-FRLSEKDRMEL 178

Query: 1908 RSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTP 1967
               ++ N       +      S    PS +  SR +G   S    P    +     +R P
Sbjct: 179  LEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIG-VSSNGAKPELSEKVTEDGTRNP 237

Query: 1968 SRR---SRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRS 2009
            + +    R+ +  S     +    S ++ T     RS  + +++S
Sbjct: 238  NEKPTQQRSIAFSSNNSVAKPIQKSAKAATEEASSRSPKIDQKKS 282


>gi|153251865 hypothetical protein LOC84226 [Homo sapiens]
          Length = 1984

 Score =  100 bits (250), Expect = 1e-20
 Identities = 93/244 (38%), Positives = 115/244 (47%), Gaps = 22/244 (9%)

Query: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRS--RSRSRRRRRSSRSRSK- 1879
            RS    S+   H   +R+    S+ R  S   +SHRS +    RS S RR RS   RS  
Sbjct: 1620 RSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSPSQRSHR 1679

Query: 1880 --SRGRRSVSKEKRKRSPKHRSKS--RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPS 1935
              S        E+R RSP  RS     ER+    S R +R   R   R+PS RS  H+PS
Sbjct: 1680 GPSERSHCSPSERRHRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHRSPSERSH-HSPS 1738

Query: 1936 RRRRSRSVGRRRSFSISPSRRSR-TPSRRSR-TPS-RRSRTPS-RRSRTPSRRS-RTPSR 1990
             R       RR     SPS RS  +PS RS  +PS RR R+PS RR  +PS +S  +PS 
Sbjct: 1739 ERSHHSPSERRHH---SPSERSHCSPSERSHCSPSERRHRSPSERRHHSPSEKSHHSPSE 1795

Query: 1991 RS-RTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKR 2049
            RS  +PS RRR   + R R   +     R  R+P  RR  RS   R   R SER  SP  
Sbjct: 1796 RSHHSPSERRRHSPLERSRHSLLE----RSHRSPSERRSHRS-FERSHRRISERSHSPSE 1850

Query: 2050 LTDL 2053
             + L
Sbjct: 1851 KSHL 1854



 Score = 93.2 bits (230), Expect = 3e-18
 Identities = 106/307 (34%), Positives = 135/307 (43%), Gaps = 41/307 (13%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKS 1836
            ER     SE       +   +   E+S+++    +     +R     SR   S  SE   
Sbjct: 1547 ERTPRGPSERTRHNPSWRNHRSPSERSQRSSLERRHHSPSQRSHCSPSRKNHSSPSERSW 1606

Query: 1837 RKRTSESRSRARKRSSKSKSHR-----SQTRSRSRSRRRRRSSRSRS----KSRGRRSVS 1887
            R  +  +     +RS  S S R     SQ   R  S+RR  S   RS      R  RS S
Sbjct: 1607 RSPSQRNHCSPPERSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRS-S 1665

Query: 1888 KEKRKRSPKHRSKS--RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR------RR 1939
             E+R RSP  RS     ER     S R +R   +   R PS R R H+PS+R      RR
Sbjct: 1666 SERRHRSPSQRSHRGPSERSHCSPSERRHRSPSQRSHRGPSER-RHHSPSKRSHRSPARR 1724

Query: 1940 SRSVGRRRSFSISPSRRSR-TPS-RRSRTPSRRSR-TPS---------RRSRTPS-RRSR 1986
            S      RS   SPS RS  +PS RR  +PS RS  +PS         RR R+PS RR  
Sbjct: 1725 SHRSPSERSHH-SPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRHRSPSERRHH 1783

Query: 1987 TPSRRS-RTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGR 2045
            +PS +S  +PS R       RRR    SP  L RSR  L  R  RSP  R+  RS E  R
Sbjct: 1784 SPSEKSHHSPSERSHHSPSERRRH---SP--LERSRHSLLERSHRSPSERRSHRSFE--R 1836

Query: 2046 SPKRLTD 2052
            S +R+++
Sbjct: 1837 SHRRISE 1843



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 94/257 (36%), Positives = 115/257 (44%), Gaps = 23/257 (8%)

Query: 1796 VKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKR--SKSSEHKSRKRTSESRSRARKRSSK 1853
            VK T  +  K+K      KE    S  R R+ R  S+ + H    R   S S   +RSS 
Sbjct: 1522 VKRTWHRHLKDKLT---HKEHNHPSFYRERTPRGPSERTRHNPSWRNHRSPSERSQRSSL 1578

Query: 1854 SKSHRSQT-RSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS-RERKRKRSSS 1911
             + H S + RS     R+  SS S    R  RS S+      P+    S  ER     S 
Sbjct: 1579 ERRHHSPSQRSHCSPSRKNHSSPSE---RSWRSPSQRNHCSPPERSCHSLSERGLHSPSQ 1635

Query: 1912 RDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRS-RTPSRRSR-TPS- 1968
            R +R   + R  +PS RS      R  RS S  R RS    PS+RS R PS RS  +PS 
Sbjct: 1636 RSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRS----PSQRSHRGPSERSHCSPSE 1691

Query: 1969 RRSRTPSRRS-RTPS-RRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRR 2026
            RR R+PS+RS R PS RR  +PS+RS     RR  RS   R   S S    R   +P  R
Sbjct: 1692 RRHRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHRSPSERSHHSPSE---RSHHSPSER 1748

Query: 2027 RFSRSPIRRKRSRSSER 2043
            R   SP  R     SER
Sbjct: 1749 R-HHSPSERSHCSPSER 1764



 Score = 82.0 bits (201), Expect = 6e-15
 Identities = 100/289 (34%), Positives = 122/289 (42%), Gaps = 56/289 (19%)

Query: 1774 SMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSE 1833
            S PER+  S SE           +  H  S+++         ++R  S   RS RS S  
Sbjct: 1616 SPPERSCHSLSE-----------RGLHSPSQRSHRGPS----QRRHHSPSERSHRSPS-- 1658

Query: 1834 HKSRKRTSESRSRARKRSSKSKSHRSQT-RSRSRSRRRRRSSRSRSKSRG---RRSVSKE 1889
                +R+  S S  R RS   +SHR  + RS      RR  S S+   RG   RR  S  
Sbjct: 1659 ----ERSHRSSSERRHRSPSQRSHRGPSERSHCSPSERRHRSPSQRSHRGPSERRHHSPS 1714

Query: 1890 KRK-RSP---KHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRS------RSHTPSRRRR 1939
            KR  RSP    HRS S ER     S R +      R  +PS RS      RSH     RR
Sbjct: 1715 KRSHRSPARRSHRSPS-ERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCSPSERR 1773

Query: 1940 SRSVGRRRSFSISPSRRS-RTPSRRS-RTPSRRSRTPSRRSRTPSRRSRTP--SRRSRTP 1995
             RS   RR    SPS +S  +PS RS  +PS       RR  +P  RSR     R  R+P
Sbjct: 1774 HRSPSERRHH--SPSEKSHHSPSERSHHSPS------ERRRHSPLERSRHSLLERSHRSP 1825

Query: 1996 SRRRRSRSVVR-RRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSER 2043
            S RR  RS  R  R  S       RS +P   +   SP+ R R   SER
Sbjct: 1826 SERRSHRSFERSHRRIS------ERSHSP-SEKSHLSPLERSRCSPSER 1867



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 85/299 (28%), Positives = 114/299 (38%), Gaps = 46/299 (15%)

Query: 1764 DRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKE-------K 1816
            +RS  SP      ER+  SSSE +            H    +  +R   E+        +
Sbjct: 1651 ERSHRSP-----SERSHRSSSERR------------HRSPSQRSHRGPSERSHCSPSERR 1693

Query: 1817 KRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRR---- 1872
             R  S RS    S+   H   KR+  S +R   RS   +SH S +     S   RR    
Sbjct: 1694 HRSPSQRSHRGPSERRHHSPSKRSHRSPARRSHRSPSERSHHSPSERSHHSPSERRHHSP 1753

Query: 1873 SSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSH 1932
            S RS      R   S  +R+    HRS S ER+    S + +         +PS R R H
Sbjct: 1754 SERSHCSPSERSHCSPSERR----HRSPS-ERRHHSPSEKSHHSPSERSHHSPSER-RRH 1807

Query: 1933 TPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSR-TPSRR 1991
            +P  R R   + R        S RS +  R  R+  R  R  S RS +PS +S  +P  R
Sbjct: 1808 SPLERSRHSLLER--------SHRSPSERRSHRSFERSHRRISERSHSPSEKSHLSPLER 1859

Query: 1992 SRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRL 2050
            SR     RR  S   +   S S    R  R+P   R  R+  R  RS       SP  +
Sbjct: 1860 SRCSPSERRGHSSSGKTCHSPSE---RSHRSPSGMRQGRTSERSHRSSCERTRHSPSEM 1915



 Score = 68.6 bits (166), Expect = 7e-11
 Identities = 78/250 (31%), Positives = 110/250 (44%), Gaps = 46/250 (18%)

Query: 1844 RSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGR------------RSVSKEKR 1891
            R+  +  SS+SK +  +  + S+  +   +  +R ++RGR            R +  +  
Sbjct: 1476 RTVQKDSSSRSKKNFYRNETSSQESKNLSTPGTRVQARGRILPGSPVKRTWHRHLKDKLT 1535

Query: 1892 KRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRS-------RSHTPSRR------R 1938
             +   H S  RER  +  S R          R+PS RS       R H+PS+R      R
Sbjct: 1536 HKEHNHPSFYRERTPRGPSERTRHNPSWRNHRSPSERSQRSSLERRHHSPSQRSHCSPSR 1595

Query: 1939 RSRSVGRRRSFSISPSRRSR-TPSRRS---------RTPSRRS-RTPS-RRSRTPSRRS- 1985
            ++ S    RS+  SPS+R+  +P  RS          +PS+RS R PS RR  +PS RS 
Sbjct: 1596 KNHSSPSERSWR-SPSQRNHCSPPERSCHSLSERGLHSPSQRSHRGPSQRRHHSPSERSH 1654

Query: 1986 RTPSRRSRTPSRRRRSRSVVRR------RSFSISPVRLRRSRTPLRRRFSRSPIRRKRSR 2039
            R+PS RS   S  RR RS  +R           SP   RR R+P +R       RR  S 
Sbjct: 1655 RSPSERSHRSSSERRHRSPSQRSHRGPSERSHCSPSE-RRHRSPSQRSHRGPSERRHHSP 1713

Query: 2040 SSERGRSPKR 2049
            S    RSP R
Sbjct: 1714 SKRSHRSPAR 1723



 Score = 68.2 bits (165), Expect = 9e-11
 Identities = 75/227 (33%), Positives = 97/227 (42%), Gaps = 36/227 (15%)

Query: 1800 HEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSH-- 1857
            H    K  +R    +   R  S RS    S+ S H   +R   S S     S   +SH  
Sbjct: 1710 HHSPSKRSHRSPARRSH-RSPSERSHHSPSERSHHSPSERRHHSPSERSHCSPSERSHCS 1768

Query: 1858 RSQTRSRSRSRRRRRSSRSRS----KSRGRRSVSKEKRKRSPKHRSKSR----------E 1903
             S+ R RS S RR  S   +S      R   S S E+R+ SP  RS+            E
Sbjct: 1769 PSERRHRSPSERRHHSPSEKSHHSPSERSHHSPS-ERRRHSPLERSRHSLLERSHRSPSE 1827

Query: 1904 RKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFS----ISPSRRS-R 1958
            R+  RS  R +R+ +  RS +PS +S      R R S S  R  S S     SPS RS R
Sbjct: 1828 RRSHRSFERSHRR-ISERSHSPSEKSHLSPLERSRCSPSERRGHSSSGKTCHSPSERSHR 1886

Query: 1959 TPS--RRSRTPSRRSRTPSRRSR---------TPSRRSR-TPSRRSR 1993
            +PS  R+ RT  R  R+   R+R          PS R+  +PS RSR
Sbjct: 1887 SPSGMRQGRTSERSHRSSCERTRHSPSEMRPGRPSGRNHCSPSERSR 1933



 Score = 55.8 bits (133), Expect = 5e-07
 Identities = 64/215 (29%), Positives = 83/215 (38%), Gaps = 29/215 (13%)

Query: 1765 RSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRS 1824
            RS +     S  ER+  S SE +          +    S   ++     + + R  S R 
Sbjct: 1727 RSPSERSHHSPSERSHHSPSERRHH-----SPSERSHCSPSERSHCSPSERRHRSPSERR 1781

Query: 1825 RSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGR- 1883
                S+ S H   +R+  S S  R+ S   +S  S      RS   RRS RS  +S  R 
Sbjct: 1782 HHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRSPSERRSHRSFERSHRRI 1841

Query: 1884 --RSVS-KEKRKRSPKHRSKSRERKRKRSSS----------RDNRKTVRARS-RTPSRRS 1929
              RS S  EK   SP  RS+    +R+  SS          R +R     R  RT  R  
Sbjct: 1842 SERSHSPSEKSHLSPLERSRCSPSERRGHSSSGKTCHSPSERSHRSPSGMRQGRTSERSH 1901

Query: 1930 RS------HTPSRRRRSRSVGRRRSFSISPSRRSR 1958
            RS      H+PS  R  R  GR      SPS RSR
Sbjct: 1902 RSSCERTRHSPSEMRPGRPSGRNH---CSPSERSR 1933



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 54/193 (27%), Positives = 76/193 (39%), Gaps = 30/193 (15%)

Query: 1799 THEKSKKNKNRDKGEKEKKRDS--SLRSRSKRSKSSEHKSRKRTSESRSRAR--KRSSKS 1854
            +H    + ++R   E+     S  S  S S+RS  S  + R+ +   RSR    +RS +S
Sbjct: 1765 SHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRS 1824

Query: 1855 KSHRSQTRSRSRSRRR-----------------RRSSRSRSKSRGRRSVSK------EKR 1891
             S R   RS  RS RR                  RS  S S+ RG  S  K      E+ 
Sbjct: 1825 PSERRSHRSFERSHRRISERSHSPSEKSHLSPLERSRCSPSERRGHSSSGKTCHSPSERS 1884

Query: 1892 KRSPK--HRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSF 1949
             RSP    + ++ ER  + S  R        R   PS R+   +PS R R   +     +
Sbjct: 1885 HRSPSGMRQGRTSERSHRSSCERTRHSPSEMRPGRPSGRNHC-SPSERSRRSPLKEGLKY 1943

Query: 1950 SISPSRRSRTPSR 1962
            S    R S + SR
Sbjct: 1944 SFPGERPSHSLSR 1956



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 63/210 (30%), Positives = 87/210 (41%), Gaps = 24/210 (11%)

Query: 1764 DRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKN-----KNRDKGEKEKKR 1818
            +RS  SP      ER   S SE +         K  H  S+++     + R     E+ R
Sbjct: 1763 ERSHCSP-----SERRHRSPSERRHHSP---SEKSHHSPSERSHHSPSERRRHSPLERSR 1814

Query: 1819 DSSL-RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQT-RSR-SRSRRRRRSSR 1875
             S L RS    S+   H+S +R S  R   R  S   KSH S   RSR S S RR  SS 
Sbjct: 1815 HSLLERSHRSPSERRSHRSFER-SHRRISERSHSPSEKSHLSPLERSRCSPSERRGHSSS 1873

Query: 1876 SRS----KSRGRRSVSKEKRKRSPK--HRSKSRERKRKRSSSRDNRKTVRARSRTPSRRS 1929
             ++      R  RS S  ++ R+ +  HRS     +   S  R  R + R    +PS RS
Sbjct: 1874 GKTCHSPSERSHRSPSGMRQGRTSERSHRSSCERTRHSPSEMRPGRPSGRNHC-SPSERS 1932

Query: 1930 RSHTPSRRRRSRSVGRRRSFSISPSRRSRT 1959
            R        +    G R S S+S   +++T
Sbjct: 1933 RRSPLKEGLKYSFPGERPSHSLSRDFKNQT 1962



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 50/193 (25%), Positives = 86/193 (44%), Gaps = 16/193 (8%)

Query: 1811 KGEKEKKRDSSLRSR-SKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRR 1869
            +G  E +     R R  KRS+ S+++ R R    RS       K+K +   ++S + S  
Sbjct: 1157 EGHGEVRLHLGFRLRIGKRSQISKYRERDRPVIRRSPISPSQRKAKIYTQASKSPT-STI 1215

Query: 1870 RRRSSRSRSKS-------RGRRS---VSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVR 1919
              +S  S+S +       RG+RS   + ++ + R+P H   ++      S S   +   R
Sbjct: 1216 DLQSGPSQSPAPVQVYIRRGQRSRPDLVEKTKTRAPGHYEFTQVHNLPESDSESTQNEKR 1275

Query: 1920 ARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSR 1979
            A+ RT  + S S  P +R   R + + R F  +      +PSR      RR R  + ++ 
Sbjct: 1276 AKVRT-KKTSDSKYPMKRITKR-LRKHRKFYTNSRTTIESPSRELAAHLRRKRIGATQTS 1333

Query: 1980 TPS--RRSRTPSR 1990
            T S  R+ + PS+
Sbjct: 1334 TASLKRQPKKPSQ 1346



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 42/110 (38%), Positives = 51/110 (46%), Gaps = 3/110 (2%)

Query: 1005 AERSMMSSYERSMMS-YERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYE 1063
            +ERS  S  ERS  S  ER   SP +ERS  S  ERS  S  ER   SP +ER   S  E
Sbjct: 1730 SERSHHSPSERSHHSPSERRHHSP-SERSHCSPSERSHCSPSERRHRSP-SERRHHSPSE 1787

Query: 1064 RSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRS 1113
            +S  S  ERS  SP   R    +   R  +   S    S   S+ + +RS
Sbjct: 1788 KSHHSPSERSHHSPSERRRHSPLERSRHSLLERSHRSPSERRSHRSFERS 1837



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 45/128 (35%), Positives = 52/128 (40%), Gaps = 16/128 (12%)

Query: 1005 AERSMMSSYERSMMS-YERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMS--- 1060
            +ER   S  E+S  S  ERS  SP +ER   S  ERS  S  ERS  SP   RS  S   
Sbjct: 1778 SERRHHSPSEKSHHSPSERSHHSP-SERRRHSPLERSRHSLLERSHRSPSERRSHRSFER 1836

Query: 1061 -----------AYERSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSA 1109
                         E+S +S  ERS  SP   R   S G      S  S    S M     
Sbjct: 1837 SHRRISERSHSPSEKSHLSPLERSRCSPSERRGHSSSGKTCHSPSERSHRSPSGMRQGRT 1896

Query: 1110 ADRSMMSS 1117
            ++RS  SS
Sbjct: 1897 SERSHRSS 1904



 Score = 37.4 bits (85), Expect = 0.17
 Identities = 40/110 (36%), Positives = 51/110 (46%), Gaps = 8/110 (7%)

Query: 1005 AERSMMSSYERSMMS-YERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYE 1063
            +ERS  SS ER   S  +RS  SP + ++  S  ERS  S  +R+  SP  ERS  S  E
Sbjct: 1570 SERSQRSSLERRHHSPSQRSHCSP-SRKNHSSPSERSWRSPSQRNHCSP-PERSCHSLSE 1627

Query: 1064 RSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRS 1113
            R + S  +RS   P   R         S  S  S ++RS  SS     RS
Sbjct: 1628 RGLHSPSQRSHRGPSQRRH-----HSPSERSHRSPSERSHRSSSERRHRS 1672



 Score = 37.0 bits (84), Expect = 0.22
 Identities = 43/119 (36%), Positives = 50/119 (42%), Gaps = 3/119 (2%)

Query: 1005 AERSMMSSYERSMMS-YERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYE 1063
            ++RS     ER   S  +RS  SP A RS  S  ERS  S  ERS  SP +ER   S  E
Sbjct: 1698 SQRSHRGPSERRHHSPSKRSHRSP-ARRSHRSPSERSHHSPSERSHHSP-SERRHHSPSE 1755

Query: 1064 RSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADR 1122
            RS  S  ERS  SP   R            S  S    S  S +S ++R   S     R
Sbjct: 1756 RSHCSPSERSHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSR 1814



 Score = 36.6 bits (83), Expect = 0.29
 Identities = 39/112 (34%), Positives = 45/112 (40%), Gaps = 1/112 (0%)

Query: 1005 AERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYER 1064
            +ER   S  +RS  S  R      +ERS  S  ERS  S  ER   SP +ERS  S  ER
Sbjct: 1706 SERRHHSPSKRSHRSPARRSHRSPSERSHHSPSERSHHSPSERRHHSP-SERSHCSPSER 1764

Query: 1065 SMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMS 1116
            S  S  ER   SP   R            S  S    S    +S  +RS  S
Sbjct: 1765 SHCSPSERRHRSPSERRHHSPSEKSHHSPSERSHHSPSERRRHSPLERSRHS 1816



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 84/358 (23%), Positives = 129/358 (36%), Gaps = 85/358 (23%)

Query: 1772 VSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKS 1831
            V ++PE  SES+  EK       K  D+    K+   R +  ++   +S     S   + 
Sbjct: 1259 VHNLPESDSESTQNEKRAKVRTKKTSDSKYPMKRITKRLRKHRKFYTNSRTTIESPSREL 1318

Query: 1832 SEHKSRKR--TSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSR-SKSRGRRSVSK 1888
            + H  RKR   +++ + + KR  K  S     +   +S +R   +  R   S GR+ V  
Sbjct: 1319 AAHLRRKRIGATQTSTASLKRQPKKPSQPKFMQLLFQSLKRAFQTAHRVIASVGRKPVDG 1378

Query: 1889 EK-----RKRSPKHRSKSRERKRKRSSSRDNRK--------------------TVRARSR 1923
             +       ++   +  +R+     S  RD R                     TV+ RS 
Sbjct: 1379 TRPDNLWASKNYYPKQNARDYCLPSSIKRDKRSADKLTPAGSTIKQEDILWGGTVQCRSA 1438

Query: 1924 TPSRRSRSHTPSRRR-------------RSRSVGR-RRSFSISPSRRSRTPSRRSRTPSR 1969
               RR+ S  P   R             ++ SVG+  R+     S RS+    R+ T S+
Sbjct: 1439 QQPRRAYSFQPRPLRLPKPTDSQSGIAFQTASVGQPLRTVQKDSSSRSKKNFYRNETSSQ 1498

Query: 1970 RSR---TPSRRSRTPSR------------------------------RSRT---PSRRSR 1993
             S+   TP  R +   R                              R RT   PS R+R
Sbjct: 1499 ESKNLSTPGTRVQARGRILPGSPVKRTWHRHLKDKLTHKEHNHPSFYRERTPRGPSERTR 1558

Query: 1994 -TPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERG-RSPKR 2049
              PS R       R +  S+     RR  +P +R    SP R+  S  SER  RSP +
Sbjct: 1559 HNPSWRNHRSPSERSQRSSLE----RRHHSPSQRSHC-SPSRKNHSSPSERSWRSPSQ 1611



 Score = 35.0 bits (79), Expect = 0.85
 Identities = 27/76 (35%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 1002 SYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSA 1061
            S  +ERS  S  +R+  S        ++ER + S  +RS     +R   SP +ERS  S 
Sbjct: 1599 SSPSERSWRSPSQRNHCSPPERSCHSLSERGLHSPSQRSHRGPSQRRHHSP-SERSHRSP 1657

Query: 1062 YERSMMSAYERSMMSP 1077
             ERS  S+ ER   SP
Sbjct: 1658 SERSHRSSSERRHRSP 1673



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 1/73 (1%)

Query: 1005 AERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYER 1064
            +ER + S  +RS     +      +ERS  S  ERS  S+ ER   SP ++RS     ER
Sbjct: 1626 SERGLHSPSQRSHRGPSQRRHHSPSERSHRSPSERSHRSSSERRHRSP-SQRSHRGPSER 1684

Query: 1065 SMMSAYERSMMSP 1077
            S  S  ER   SP
Sbjct: 1685 SHCSPSERRHRSP 1697



 Score = 33.9 bits (76), Expect = 1.9
 Identities = 45/122 (36%), Positives = 54/122 (44%), Gaps = 16/122 (13%)

Query: 1005 AERSMMSSYERSMMS---------YERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAE 1055
            +ERS  SS ER   S          ERS  SP +ER   S  +RS     ER   SP ++
Sbjct: 1658 SERSHRSSSERRHRSPSQRSHRGPSERSHCSP-SERRHRSPSQRSHRGPSERRHHSP-SK 1715

Query: 1056 RSMMSAYERSMMSAYERSMMSPMADRSMMSMGADR----SMMSSYSAADRSMMSSYSAAD 1111
            RS  S   RS  S  ERS  SP ++RS  S    R    S  S  S ++RS  S      
Sbjct: 1716 RSHRSPARRSHRSPSERSHHSP-SERSHHSPSERRHHSPSERSHCSPSERSHCSPSERRH 1774

Query: 1112 RS 1113
            RS
Sbjct: 1775 RS 1776


>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
          Length = 484

 Score =  100 bits (249), Expect = 2e-20
 Identities = 71/210 (33%), Positives = 103/210 (49%), Gaps = 5/210 (2%)

Query: 1796 VKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSK 1855
            V  + +    +K  ++  K  +   SL S +      E K R   S SRSR R+  S S+
Sbjct: 206  VSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSR 265

Query: 1856 SHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNR 1915
              RS++RSR RS  + RS R     R RRS S+E+ +RS   RS S+ R +K+      R
Sbjct: 266  HRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRS---RSTSKTRDKKKEDKEKKR 322

Query: 1916 KTVRARSRTPSRRSRSHT-PSRRRRSRSVGRRRSFSISPSRR-SRTPSRRSRTPSRRSRT 1973
                 +S + +RRSRS +   RRRRSRS  R      SP R+ SR+PS R     ++   
Sbjct: 323  SKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDK 382

Query: 1974 PSRRSRTPSRRSRTPSRRSRTPSRRRRSRS 2003
               RSR    RS +  ++S+   + R  +S
Sbjct: 383  DKERSRDERERSTSKKKKSKDKEKDRERKS 412



 Score = 99.0 bits (245), Expect = 5e-20
 Identities = 84/245 (34%), Positives = 121/245 (49%), Gaps = 39/245 (15%)

Query: 1821 SLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKS 1880
            SL+S +   +  E   R R ++S   A     K +  R  +RSRSRSRRRR  S SR + 
Sbjct: 209  SLKSDTSSKEIEEAMKRVREAQSLISAAIEPDKKEEKRRHSRSRSRSRRRRTPSSSRHR- 267

Query: 1881 RGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRS 1940
                             RS+SR R+R  S SR  R     RS++P RR RSH+  R RRS
Sbjct: 268  -----------------RSRSRSRRRSHSKSRSRR-----RSKSP-RRRRSHSRERGRRS 304

Query: 1941 RSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRR-R 1999
            RS  + R       ++     +RS+TP  +S + +RRSR+ SR  R   RRSR+ +R  +
Sbjct: 305  RSTSKTRD-----KKKEDKEKKRSKTPP-KSYSTARRSRSASRERR--RRRSRSGTRSPK 356

Query: 2000 RSRSVVRRRSFSISPVRLRRSRTP------LRRRFSRSPIRRKRSRSSERGRSPKRLTDL 2053
            + RS  R+ S S SP R ++ +         R    RS  ++K+S+  E+ R  K  +D 
Sbjct: 357  KPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDK 416

Query: 2054 DKAQL 2058
            D  Q+
Sbjct: 417  DVKQV 421



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 45/189 (23%), Positives = 87/189 (46%), Gaps = 13/189 (6%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEK-------- 1814
            R RS      SS   R S S S  +   +   + +    + +++ +R++G +        
Sbjct: 252  RSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRERGRRSRSTSKTR 311

Query: 1815 EKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKS----KSHRSQTRSRSRSRRR 1870
            +KK++   + RSK    S   +R+  S SR R R+RS       K  RS  R  SRS   
Sbjct: 312  DKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSP 371

Query: 1871 RRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSR 1930
            RR  + + K + +   S+++R+RS   + KS+++++ R    ++ K V+  +R      +
Sbjct: 372  RRHKKEKKKDKDKER-SRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQ 430

Query: 1931 SHTPSRRRR 1939
             +   + ++
Sbjct: 431  GYDSEKEKK 439



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 29/154 (18%), Positives = 58/154 (37%), Gaps = 6/154 (3%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            R RS +        ++  + S      Y    + +    + ++ ++R      KK  S  
Sbjct: 303  RSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPK 362

Query: 1823 RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSR------S 1876
            R  S+      HK  K+  + + R+R    +S S + +++ + + R R+  S       +
Sbjct: 363  RKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVT 422

Query: 1877 RSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSS 1910
            R      +    EK K+  K   ++   K K  S
Sbjct: 423  RDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECS 456



 Score = 37.7 bits (86), Expect = 0.13
 Identities = 26/88 (29%), Positives = 40/88 (45%), Gaps = 2/88 (2%)

Query: 1802 KSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSE-HKSRKRTSESRSRARKRSSKSKSHRSQ 1860
            + KK K +DK +KE+ RD   RS SK+ KS +  K R+R SES    ++ +         
Sbjct: 373  RHKKEKKKDK-DKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQG 431

Query: 1861 TRSRSRSRRRRRSSRSRSKSRGRRSVSK 1888
              S    +  ++   + S      SV K
Sbjct: 432  YDSEKEKKEEKKPIETGSPKTKECSVEK 459



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 27/114 (23%), Positives = 46/114 (40%), Gaps = 1/114 (0%)

Query: 42  EGNQAGDAAASARSLPNEEIVQKIEEVLSGVLDTELRYKPDLKEGSRKSRCVSVQTDPTD 101
           E  +   + +  R    E+  +K  +       T  R +   +E  R+      ++    
Sbjct: 299 ERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKP 358

Query: 102 EIPTKKSKKHKKHKNKKKKKKKEKEKKYKR-QPEESESKTKSHDDGNIDLESDS 154
             P +K  +    +  KK+KKK+K+K+  R + E S SK K   D   D E  S
Sbjct: 359 RSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKS 412



 Score = 32.0 bits (71), Expect = 7.2
 Identities = 16/60 (26%), Positives = 33/60 (55%), Gaps = 3/60 (5%)

Query: 106 KKSKKHKKHKNKKKKKKKEKEKKYKRQPE---ESESKTKSHDDGNIDLESDSFLKFDSEP 162
           ++S+  ++    KKKK K+KEK  +R+ E   + +  T+ +D+     +S+   K + +P
Sbjct: 385 ERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKP 444


>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
          Length = 904

 Score =  100 bits (249), Expect = 2e-20
 Identities = 101/299 (33%), Positives = 138/299 (46%), Gaps = 34/299 (11%)

Query: 1767 AASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKN-RDKGEKEKKRDSSLRSR 1825
            +A   ++ +P    E   EE    +I  +   + +K  ++K+ RDK EKE  R+   RSR
Sbjct: 111  SAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSR 170

Query: 1826 SKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRS 1885
            S R + S   S +R S    R RKRS             SRS R R  SRS S +  +  
Sbjct: 171  SPRRRKSRSPSPRRRSSPVRRERKRS------------HSRSPRHRTKSRSPSPAPEK-- 216

Query: 1886 VSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRS-HTPSRRRRSRSVG 1944
              KEK    P+   K +E   + ++S  +   V      P  +  S    S++ + +   
Sbjct: 217  --KEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKT 274

Query: 1945 RRRSFSISPSRRSRT---------PSRRSRTPSRRSRTPSRR---SRTPSRRSRTPSRRS 1992
            R RS S S SR SRT         P RR R+ S RS +P RR    R PS R RTP RR 
Sbjct: 275  RPRSRSRSKSR-SRTRSRSPSHTRPRRRHRSRS-RSYSPRRRPSPRRRPSPRRRTPPRRM 332

Query: 1993 RTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLT 2051
              P R RRSRS VRRR  S + +    S +   R  SRSP ++   R+S   R  +RL+
Sbjct: 333  PPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSR--SRSPPKKPPKRTSSPPRKTRRLS 389



 Score = 99.8 bits (247), Expect = 3e-20
 Identities = 126/471 (26%), Positives = 192/471 (40%), Gaps = 58/471 (12%)

Query: 1696 LSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGP 1755
            LSP  S    +  P PP    P +  S   +  N     R           S+  G    
Sbjct: 388  LSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSR----------VSVSPGRTSG 437

Query: 1756 LLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIF----VKVKDTHEKSKKNKNRDK 1811
             +    G ++   SP  +  P +   S SEE    ++     V+ +  + +  +  + D 
Sbjct: 438  KVTKHKGTEKRE-SPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDS 496

Query: 1812 GEKEKKRDS------------SLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRS 1859
            G      D               R R   S+S+    RKR  E+  R R+R S S     
Sbjct: 497  GSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTR 556

Query: 1860 QTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTV- 1918
            + RS S +   RR  R+ +    RR+ S   R+RSP  R  S   +R+ S S   ++   
Sbjct: 557  RRRSPSPAPPPRR-RRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTA 615

Query: 1919 --------RARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPS-RRSRTPSRRSRTPSR 1969
                    RA    P +R  SH+P  ++RS  V +RRS S+S   R+  +PSR +R    
Sbjct: 616  SPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTR--EA 673

Query: 1970 RSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRR---SFSISPVRLRRSRTP--- 2023
            RS  P++R  +PS R R P   S  P  RR + S  +RR   S S  P+R R SRTP   
Sbjct: 674  RSPQPNKR-HSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIR-RVSRTPEPK 731

Query: 2024 -LRRRFSRSP--IRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPN 2080
             +++  S SP  +RR  S  S  G SP+       A    +   + +   + A VP+   
Sbjct: 732  KIKKAASPSPQSVRRVSSSRSVSG-SPEPAAKKPPAPPSPVQSQSPSTNWSPA-VPVKKA 789

Query: 2081 LKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDE 2131
              P P P+      ++ GG       +K K+  + K+D     +K H  ++
Sbjct: 790  KSPTPSPSPPRNSDQEGGGK-----KKKKKKDKKHKKDKKHKKHKKHKKEK 835



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 110/424 (25%), Positives = 177/424 (41%), Gaps = 58/424 (13%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL 1822
            + R      ++SM ++  +    +K++ E   + ++     ++ K+R    +  +R S +
Sbjct: 132  KQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPR--RRSSPV 189

Query: 1823 RSRSKRS--KSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKS 1880
            R   KRS  +S  H+++ R+        K+    +      + +  S +   S+    K 
Sbjct: 190  RRERKRSHSRSPRHRTKSRSPS--PAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKV 247

Query: 1881 RGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRS 1940
                 + + K     K+  K +E+++ R  SR   K   +RSRT S RS SHT  RRR  
Sbjct: 248  PKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSK---SRSRTRS-RSPSHTRPRRRH- 302

Query: 1941 RSVGRRRSFSISPSRR---SRTPSRRSRTPSRRSRTP--SRRSRTPSRRSR--------- 1986
                R RS S SP RR    R PS R RTP RR   P   RRSR+P RR R         
Sbjct: 303  ----RSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGS 358

Query: 1987 ---TPSRRSRTPSRRRRSRS-----VVRRRSFSISPVRLRR-----SRTPLRRRFSRSPI 2033
               + S RSR+P ++   R+       RR S S SP R R      +  P + R S +P 
Sbjct: 359  SSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQ 418

Query: 2034 RRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPPTIEEKV 2093
            +  R+R S    SP R +        ++ K        ++  P P   K     + E+K 
Sbjct: 419  QSNRTRKSRVSVSPGRTSG-------KVTKHKGTEK-RESPSPAPKPRKVELSESEEDKG 470

Query: 2094 AKKSGGATIEELTEKCKQIAQSKED-------DDVIVNKPHVSDEEEEEPPFYHHPFKLS 2146
             K +   ++++  +  +Q  QS  D       +D    + HV + E       H P + +
Sbjct: 471  GKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRR-RHSPSRSA 529

Query: 2147 EPKP 2150
             P P
Sbjct: 530  SPSP 533



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 97/337 (28%), Positives = 129/337 (38%), Gaps = 58/337 (17%)

Query: 1804 KKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKS----RKRTSESRSRARKRSSKSKSHRS 1859
            +++++R +    ++R S  R  S R ++   +     R R S S  R R+RSS S S  S
Sbjct: 300  RRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSS 359

Query: 1860 QTRSRSRS---------------RRRRRSSRSRSKSRGRRSVS-----KEKRKRSPKHRS 1899
             + S SRS               R+ RR S S S  R R   S       K + SP  + 
Sbjct: 360  SSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQ 419

Query: 1900 KSRERKRKRSSS--RDNRKTVRARSRTPSRRSRSHTPSRRR---------------RSRS 1942
             +R RK + S S  R + K  + +  T  R S S  P  R+                + S
Sbjct: 420  SNRTRKSRVSVSPGRTSGKVTKHKG-TEKRESPSPAPKPRKVELSESEEDKGGKMAAADS 478

Query: 1943 VGRRRSF--------SISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRT 1994
            V +RR +        S S S  S    R  R+  +      RR  +PS RS +PS R R 
Sbjct: 479  VQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPS-RSASPSPRKRQ 537

Query: 1995 PSRRRRSRSVVRRRSFSISPVRLRRSRTPL----RRRFSRSPIRRKRSRSSERGRSPKRL 2050
                 R R   RRRS S  P R RRS +P     RRR    P RR+      R RSP   
Sbjct: 538  KETSPRGR---RRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPR 594

Query: 2051 TDLDKAQLLEIAKANAAAMCAKAGVPLPPNLKPAPPP 2087
                  Q             A    P      P+PPP
Sbjct: 595  RYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPP 631



 Score = 39.7 bits (91), Expect = 0.035
 Identities = 101/452 (22%), Positives = 149/452 (32%), Gaps = 66/452 (14%)

Query: 81  PDLKEGSRKSRCVSVQ--TDPTDEI------PTKKSKKHKKHKNKKKKKKKEKEKKYKRQ 132
           P+L E S K +  SVQ  T  +D +      P  + K+    KN KK+K+KEK +   R 
Sbjct: 221 PELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRS 280

Query: 133 PEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVV 192
             +S S+T+S    +         +     S      P+    PS    +P   + PP  
Sbjct: 281 RSKSRSRTRSRSPSHTRPRRRHRSR---SRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPR 337

Query: 193 SMEVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPE-----PSMTKILDSFAA 247
                 P      +    +A LS  S+S  S +S       P+     P  T+ L   A+
Sbjct: 338 HRRSRSP----VRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSAS 393

Query: 248 AP------------------VPTTTLVLKSSEPVVTMSVEYQMKSVLK-------SVEST 282
            P                   PT     ++ +  V++S       V K          S 
Sbjct: 394 PPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSP 453

Query: 283 SPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQ 342
           +P+P K+ L E    K     +     S      Y   +  ++ D   SS+ E  R P++
Sbjct: 454 APKPRKVELSESEEDK---GGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDER-PKR 509

Query: 343 PVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPPAT---SMPELQGPP- 398
                 E+       P      P     + + S        P PP T     P    PP 
Sbjct: 510 SHVKNGEVGRRRRHSPSRSAS-PSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPR 568

Query: 399 ----VTPVLELPGPSATPVPELPGP--LSTPVPE--LPGPPATAVPELPGPSVTPVPQLS 450
                TP      PS  P    P P   S P+     P PP    P+    S  P P+  
Sbjct: 569 RRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPP----PKRRTASPPPPPKRR 624

Query: 451 QELPGLPAPSMGLEPPQEVPEPPVMAQELPGL 482
                 P   +   PP +    PV  +  P L
Sbjct: 625 ASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSL 656



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 38/163 (23%), Positives = 57/163 (34%), Gaps = 10/163 (6%)

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPT-----EVPSS 1202
            P PP +  T  P PP +   +P  PP+        P ++S+   +   P+        SS
Sbjct: 606  PSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSS 665

Query: 1203 PSEES--VSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSIT 1260
            PS  +     P+P    S    P A  T  S          S      P P   P   ++
Sbjct: 666  PSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVS 725

Query: 1261 LTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPP 1303
             TP    +   +    P       VS + ++S  P   A +PP
Sbjct: 726  RTPEPKKI---KKAASPSPQSVRRVSSSRSVSGSPEPAAKKPP 765



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 66/305 (21%), Positives = 102/305 (33%), Gaps = 19/305 (6%)

Query: 959  TPDPYRMSPRPYRIAP---RSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYER 1015
            +P P R SP P R +P   R Y  +P P R    P     RR+        R   S   +
Sbjct: 583  SPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPK 642

Query: 1016 SMMSYERSMMSPMAERSMMSAYER-SMMSAYERSMMSPMAERSMMSAYERSMMSAYERSM 1074
               S      SP    S+ S + + S  S   R   SP   +     +  S      ++ 
Sbjct: 643  QRSSPVTKRRSP----SLSSKHRKGSSPSRSTREARSPQPNK----RHSPSPRPRAPQTS 694

Query: 1075 MSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTADRSMMSMAADSYTD 1134
             SP   R   S    R    S S      +   S           A  S  S+   S + 
Sbjct: 695  SSPPPVRRGASSSPQRRQSPSPSTRP---IRRVSRTPEPKKIKKAASPSPQSVRRVSSSR 751

Query: 1135 SYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALP--TEQSALTAE 1192
            S + +   A   PP PP    +  P      P  P    + P   P+ P  ++Q     +
Sbjct: 752  SVSGSPEPAAKKPPAPPSPVQSQSP-STNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKK 810

Query: 1193 NTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPP 1252
                 +      ++     +    ++  +  +A  T  +++A+  + L  E  V  PEP 
Sbjct: 811  KKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAA-TTTLAQEEPVAAPEPK 869

Query: 1253 PEPES 1257
             E ES
Sbjct: 870  KETES 874



 Score = 35.0 bits (79), Expect = 0.85
 Identities = 75/347 (21%), Positives = 119/347 (34%), Gaps = 41/347 (11%)

Query: 106 KKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAV 165
           KK  + K  ++K++K+   ++++  R P   +S++ S    +  +  +        P   
Sbjct: 145 KKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRH- 203

Query: 166 ALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAE-LSVVSTSVISE 224
                T++  PS   E      E P  S++V EP + E    AT T++ L V     I E
Sbjct: 204 ----RTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQE----ATSTSDILKVPKPEPIPE 255

Query: 225 QSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSP 284
             E S    PE +  K  +     P   +    +S     + S     +       S SP
Sbjct: 256 PKEPS----PEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSP 311

Query: 285 --EPSKIMLVEP----PVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALR 338
              PS      P    P  ++  P       S +P       S S +     SS+  +  
Sbjct: 312 RRRPSPRRRPSPRRRTPPRRMPPPPRHR--RSRSPVRRRRRSSASLSGSSSSSSSSRSRS 369

Query: 339 LPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAMELPGPPATSMPELQGPP 398
            P++P              P+     P+ T      +S       P PPAT  P+ +  P
Sbjct: 370 PPKKP--------------PKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSP 415

Query: 399 VTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTP 445
                     S   V   PG  S  V +  G   T   E P P+  P
Sbjct: 416 TPQQSNRTRKSRVSVS--PGRTSGKVTKHKG---TEKRESPSPAPKP 457



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 15/22 (68%), Positives = 16/22 (72%)

Query: 106 KKSKKHKKHKNKKKKKKKEKEK 127
           KK KKHKK K  KK KK +KEK
Sbjct: 814 KKDKKHKKDKKHKKHKKHKKEK 835



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 59/251 (23%), Positives = 88/251 (35%), Gaps = 43/251 (17%)

Query: 1147 PPLPPEEPPTMPPLPPEEPPMTPP----------LPPEEPPEGPALPTEQSALTAENTWP 1196
            P  PP    T  P P    P  PP           PP +    P+ P ++   TA    P
Sbjct: 563  PAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRR--TASPPPP 620

Query: 1197 TE---VPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP-- 1251
             +    PS P +  VS   PP  +S        P+  S      S   S      P+P  
Sbjct: 621  PKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNK 680

Query: 1252 -------PPEPESSITLTPVESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPV 1304
                   P  P++S +  PV     +      P+R       ++P+ S  P    S  P 
Sbjct: 681  RHSPSPRPRAPQTSSSPPPVRRGASSS-----PQR------RQSPSPSTRPIRRVSRTP- 728

Query: 1305 MSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAP-ESSAMAVLESS 1363
              E  +   +   S      VS+S  V     P    +  +PPA  +P +S + +   S 
Sbjct: 729  --EPKKIKKAASPSPQSVRRVSSSRSVSGSPEP----AAKKPPAPPSPVQSQSPSTNWSP 782

Query: 1364 AVTVLESSTVT 1374
            AV V ++ + T
Sbjct: 783  AVPVKKAKSPT 793



 Score = 32.0 bits (71), Expect = 7.2
 Identities = 34/142 (23%), Positives = 59/142 (41%), Gaps = 21/142 (14%)

Query: 94  SVQTDPTDEIPTKKSK---------KHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHD 144
           S  T+ +  +P KK+K         ++   +   KKKKK+K+KK+K+     + K K H 
Sbjct: 775 SPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKK-----DKKHKKHK 829

Query: 145 DGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILET 204
               +    +       P+A+A    T A       E P    EP   +   +E + L+ 
Sbjct: 830 KHKKEKAVAAAAAAAVTPAAIAAATTTLA------QEEPVAAPEPKKETESEAEDN-LDD 882

Query: 205 LKPATKTAELSVVSTSVISEQS 226
           L+   +   L  +  + +S QS
Sbjct: 883 LEKHLREKALRSMRKAQVSPQS 904


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score =  100 bits (248), Expect = 2e-20
 Identities = 131/478 (27%), Positives = 207/478 (43%), Gaps = 56/478 (11%)

Query: 1527 EHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTYPGVS- 1585
            E G   +  I++  + +E +   V     S   E  ++ IL T ++ +  +   +  V+ 
Sbjct: 1021 EFGEEEEEEIDDKQVTQESKEKKV-----SENNETIKDNILKTEKSSEEDLSGKHDTVTV 1075

Query: 1586 EADAGETLSSTGPFALEPDATGTSKGIEFTTASTLSLVNKYDVDLSLTTQD---TEHDMV 1642
             +D  +        ++ P A  T + +     + L  +   +  +    +D   T+ +M 
Sbjct: 1076 SSDLDQFTKDDSKLSISPTALNTEENV-----ACLQNIQHVEESVPNGVEDVLQTDDNME 1130

Query: 1643 ISTSPSGGSEADIEGPLPAKDIHLDLPSNNNLVSKDTEEPLPVKESDQTLAALLSPKESS 1702
            I T P   S A +E   P  +  LD P  N ++ +D     P  E  +  +++   K   
Sbjct: 1131 ICT-PDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVL- 1188

Query: 1703 GGEKEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVG 1762
             GE         +L  +G S   +++ E   +  L+ K  + L  +     G L A +  
Sbjct: 1189 -GEVGKQDSSSASLASAGESTGKKEVAEKSQIN-LIDKKWKPLQGV-----GNLAAPNAA 1241

Query: 1763 RDRSAASPVVSSMPE------RASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKE- 1815
               +    V++++PE      R    S  +     +F +V+ T   +++ +N++    E 
Sbjct: 1242 TSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQ 1301

Query: 1816 ---KKRDSSLRSRSKRSKSSEHKSRKRT---SESRSRARKRSSKSKSHRSQTRSRSRSRR 1869
               +  DS  RS S+    SE KSR RT   S S SR+R RSS S S+RS++ SRSRSR 
Sbjct: 1302 TPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTS-SYRSRSYSRSRSRG 1360

Query: 1870 RRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRT-PSRR 1928
                 R+RS+S   RS           HR+ S  R R RSSS D     R+RS T  S  
Sbjct: 1361 WYSRGRTRSRSSSYRSYK--------SHRTSS--RSRSRSSSYDPHS--RSRSYTYDSYY 1408

Query: 1929 SRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSR 1986
            SRS + SR +RS S  R RS+    +RRSR  S RS      S       R+PS  SR
Sbjct: 1409 SRSRSRSRSQRSDSYHRGRSY----NRRSR--SCRSYGSDSESDRSYSHHRSPSESSR 1460



 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 95/350 (27%), Positives = 142/350 (40%), Gaps = 66/350 (18%)

Query: 1756 LLASDVGRDRSAASPVVSSMP-ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEK 1814
            L+ SD+   +S+   + SS   ER+S SSS              +H  SK    RD  + 
Sbjct: 460  LIPSDIESSKSSTRRMKSSCDRERSSRSSS------------LSSHHSSK----RDWSKS 503

Query: 1815 EKKRDSSLRSRSKRS-KSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRS 1873
            +K   SSL   S+ S +S  H        SRSR   +SS     RS++RS S+S  R+R+
Sbjct: 504  DKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRA 563

Query: 1874 SRSRSKSRGRRSVSKEKRKR------------------------------SPKHRSKSRE 1903
            S+S  K+  + S +K  +                                 P  R K  +
Sbjct: 564  SKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQ 623

Query: 1904 RKRKRSSSRDNRKTVRARSRTPSRRSRS--------HTPSRRRRSRSVGRRRSFSISPSR 1955
            +  K S  R      +     P + + S         + S  +R ++    +S     S 
Sbjct: 624  KPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSD 683

Query: 1956 RSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRS------ 2009
            RS   S RSR+ S RSR+ S RS T SR   +   RSR+PS R  SR+     S      
Sbjct: 684  RSSESSPRSRSRSSRSRSYS-RSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSS 742

Query: 2010 --FSISPVRLRRSRTPLRRRFSRSPI-RRKRSRSSERGRSPKRLTDLDKA 2056
               SIS    RR++  LR    ++ +  +K S SSE+    K +   D++
Sbjct: 743  SYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRS 792



 Score = 68.6 bits (166), Expect = 7e-11
 Identities = 115/402 (28%), Positives = 169/402 (42%), Gaps = 59/402 (14%)

Query: 1677 KDTEEPLPVKESDQTLAALLSPKESSGGEKEVPPPPKETLPDSGFSANIEDINEA--DLV 1734
            K +EE L  K    T+++ L        +  + P    T  +     NI+ + E+  + V
Sbjct: 1060 KSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGV 1119

Query: 1735 RPLLPKD--MERLTSLR--------------AGIEGPLLASDVGRDRSAASPVVSSMPER 1778
              +L  D  ME  T  R              A ++ P +   + +D +   P    + + 
Sbjct: 1120 EDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQE 1179

Query: 1779 ASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRK 1838
            +S S S+   +    V  +D+   S  +     G+KE    S +    K+ K  +     
Sbjct: 1180 SSMSESKVLGE----VGKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNL 1235

Query: 1839 RTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHR 1898
                + +     SS  +     T    + +  R   +S++K R   S+  E RK +  +R
Sbjct: 1236 AAPNAAT-----SSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPG-SLFDEVRKTARLNR 1289

Query: 1899 SKSRERKRKRSSSRDNRKTVR---ARSRTPSR-RSRSHTPSRRRRSRSVGRRRSFSISPS 1954
                 R R + SS D +   R   ++SR+PSR RS+S T SR R +RSV    S+S S S
Sbjct: 1290 -----RPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHR-TRSV----SYSHSRS 1339

Query: 1955 R-RSRTPSRRSRTPSR-RSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVV-----RR 2007
            R RS T S RSR+ SR RSR    R RT SR S   S +S   S R RSRS       R 
Sbjct: 1340 RSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRS 1399

Query: 2008 RSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKR 2049
            RS++      R          SRS  R +RS S  RGRS  R
Sbjct: 1400 RSYTYDSYYSR----------SRSRSRSQRSDSYHRGRSYNR 1431



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 68/232 (29%), Positives = 91/232 (39%), Gaps = 25/232 (10%)

Query: 1829 SKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSK 1888
            S SS HK  K +   +S   K S +S    S++  RSRSR  R  S SRS +R R   S 
Sbjct: 660  SSSSYHKREKNSESDQSTYSKYSDRS----SESSPRSRSRSSRSRSYSRSYTRSRSLASS 715

Query: 1889 EKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRR--RRSRSVGRR 1946
              R RSP  RS SR +    S            SR+ S  S S    RR  RR RS G++
Sbjct: 716  HSRSRSPSSRSHSRNKYSDHSQC----------SRSSSYTSISSDDGRRAKRRLRSSGKK 765

Query: 1947 RSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSR------TPSRRRR 2000
             S S      S   +  S+    R R+   R  + SR S   S  S       T S + +
Sbjct: 766  NSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEK 825

Query: 2001 SRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSE---RGRSPKR 2049
             +     R+ +         ++   R    S  R  +   S+    G  PKR
Sbjct: 826  EKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKR 877



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 74/305 (24%), Positives = 117/305 (38%), Gaps = 33/305 (10%)

Query: 1755 PLLASDVGRDRSAASPVV-----------SSMPERASESSSEEKDDYEIF--VKVKDTH- 1800
            PL A+    +     PVV           S  P R        K  YE    +K K TH 
Sbjct: 584  PLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHL 643

Query: 1801 ------------EKSKKNKNRDKGEKEKKRDSSLRSR-SKRSKSSEHKSRKRTSESRSRA 1847
                        +++  + +  K EK  + D S  S+ S RS  S  +SR R+S SRS +
Sbjct: 644  LPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYS 703

Query: 1848 RKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRK 1907
            R  +       S +RSRS S R    S SR+K       S+     S       R ++R 
Sbjct: 704  RSYTRSRSLASSHSRSRSPSSR----SHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRL 759

Query: 1908 RSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTP 1967
            RSS + N  + +  S +  +   S     R RS  V R+ S S S    S    + S   
Sbjct: 760  RSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCV-RKYSESRSSLDYSSDSEQSSVQA 818

Query: 1968 SRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSIS-PVRLRRSRTPLRR 2026
            ++ ++   ++ +     ++    R    S+  R     ++R+   +    LR    P R+
Sbjct: 819  TQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRK 878

Query: 2027 RFSRS 2031
             ++ S
Sbjct: 879  NYAGS 883



 Score = 58.2 bits (139), Expect = 9e-08
 Identities = 80/314 (25%), Positives = 122/314 (38%), Gaps = 26/314 (8%)

Query: 1651 SEADIEGPLPAKDIHLDLPSNNNLVSKD----TEEPLPVKESDQTLAALLSPKESSGGEK 1706
            S A  E P+   +    +P N  L+ +D    T EP P       + +   P  S  G K
Sbjct: 273  SSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRK 332

Query: 1707 -EVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDR 1765
             +     +   P    S +  D +++    P   ++M+RL + R     P       +  
Sbjct: 333  IKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYR-----PPSGEKWSKGD 387

Query: 1766 SAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSR 1825
              + P  S   ER S S       Y  +     T   S  +K R K +K K +       
Sbjct: 388  KLSDPCSSRWDER-SLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHK------- 439

Query: 1826 SKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSR---G 1882
                K  + K  +R  +++ R     S  +S +S TR    S  R RSSRS S S     
Sbjct: 440  ---KKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSS 496

Query: 1883 RRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSR-RSRSHTPSRRRRSR 1941
            +R  SK  +         SR+  R +S S+   +   +RSRT S+  S S + S+ R S 
Sbjct: 497  KRDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRG-SSRSRTASKSSSHSRSRSKSRSSS 555

Query: 1942 SVGRRRSFSISPSR 1955
              G R+  S SP +
Sbjct: 556  KSGHRKRASKSPRK 569



 Score = 53.1 bits (126), Expect = 3e-06
 Identities = 62/256 (24%), Positives = 102/256 (39%), Gaps = 30/256 (11%)

Query: 1772 VSSMPERASESSSEEKD-----DYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRS 1826
            ++++ E  S SS  +++     D   + K  D   +S ++  R +    + R  S     
Sbjct: 652  LANIKETGSSSSYHKREKNSESDQSTYSKYSD---RSSESSPRSRSRSSRSRSYSRSYTR 708

Query: 1827 KRSKSSEHKSRKRTSESRSRARKR------SSKSKSHR--SQTRSRSRSRRRRRSSRSRS 1878
             RS +S H SR R+  SRS +R +       S+S S+   S    R   RR R S +  S
Sbjct: 709  SRSLASSH-SRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNS 767

Query: 1879 KSRGRRSVSKEK---------RKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRS 1929
             S  + S S EK         R RS   R  S  R     SS   + +V+A      +  
Sbjct: 768  VSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEK 827

Query: 1930 R---SHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR-RS 1985
            +     T +++ ++R   + +S    P  + RT         R    P R++   S+  S
Sbjct: 828  QGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDS 887

Query: 1986 RTPSRRSRTPSRRRRS 2001
             + S R  T + +  S
Sbjct: 888  ESNSERDVTKNSKNDS 903



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 23/100 (23%), Positives = 41/100 (41%)

Query: 1796 VKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSK 1855
            +KD  EK +K     +G       SS    S  S+    +SR+R  + R + ++   + K
Sbjct: 181  IKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRK 240

Query: 1856 SHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSP 1895
               S    R++     +    RS +  +RSV    ++  P
Sbjct: 241  EASSSEEPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKP 280



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 110/493 (22%), Positives = 183/493 (37%), Gaps = 107/493 (21%)

Query: 1780 SESSSEEKDDYEIFVKVKDTHEKSK--KNKNRDKGEKEKKR----DSSLRSRSKRSKSSE 1833
            S SSSE   + E+       HE+S+  K+K R K ++ KKR     SS   R+K + + +
Sbjct: 204  SSSSSESSSESEL------EHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPK 257

Query: 1834 -HKSRKRTSESR---SRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSK---------- 1879
             H  R  T+E R   S A++     +         +R   RR      ++          
Sbjct: 258  GHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAP 317

Query: 1880 --SRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSR---DNRKTVRARSRTPSRRSRSHTP 1934
              S  + SVSK  RK   +   +     R RS S    D+        +   +R R++ P
Sbjct: 318  IVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRP 377

Query: 1935 ----------------SRRRRSRSVGRR-RSFS-------ISPSRRSRTPSRRSRTPSRR 1970
                            S R   RS+ +R RS+S       +S +R S    +R +    +
Sbjct: 378  PSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVK 437

Query: 1971 SRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRT-----PLR 2025
             +   ++ +   R  +T  RR   PS    S+S  RR   S    R  RS +       +
Sbjct: 438  HKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSK 497

Query: 2026 RRFSRSP---------------IRRKRSRSSERGRSPKRLTDLDKAQLLEIAKANAAAMC 2070
            R +S+S                  +  S+S  RG S  R      +     +K+ ++   
Sbjct: 498  RDWSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSS--- 554

Query: 2071 AKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTE----KCKQIAQSKEDDDVIVNKP 2126
            +K+G                 K A KS   T  +L+E    K + +  +   ++ +V +P
Sbjct: 555  SKSG---------------HRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQP 599

Query: 2127 HVSDE------EEEEPPFYHHPFKLSEPKPIFFNLNIAAAKPT---PPKSQVTLTKEFPV 2177
             V++        +  PP    P +    KP +  +    AK T   P +S  +L      
Sbjct: 600  VVAENIPVIPLSDSPPPSRWKPGQ-KPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKET 658

Query: 2178 SSGSQHRKKEADS 2190
             S S + K+E +S
Sbjct: 659  GSSSSYHKREKNS 671



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 53/255 (20%), Positives = 101/255 (39%), Gaps = 42/255 (16%)

Query: 1762 GRDRSA---------ASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKG 1812
            GRDRS+         +S   SS  E++S  +++   + E   +++ TH K +KN+  +K 
Sbjct: 788  GRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEK- 846

Query: 1813 EKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRR 1872
                         SK  +   H  ++   E+ S   +  SK K            R+   
Sbjct: 847  -------------SKSERECPHSKKRTLKENLSDHLRNGSKPK------------RKNYA 881

Query: 1873 SSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSH 1932
             S+  S+S   R V+K  +  S  H S  +E     S S      +  + + P+ +S ++
Sbjct: 882  GSKWDSESNSERDVTKNSKNDS--HPSSDKEEGEATSDSESEVSEIHIKVK-PTTKSSTN 938

Query: 1933 T--PSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRR--SRTPSRRSRTPSRRSRTP 1988
            T  P      +S  +R S S S    S + + R +    +  S+   +R  T   + +  
Sbjct: 939  TSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLK 998

Query: 1989 SRRSRTPSRRRRSRS 2003
             ++ +     +R ++
Sbjct: 999  GKKDKKHKAPKRKQA 1013



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 80/376 (21%), Positives = 147/376 (39%), Gaps = 19/376 (5%)

Query: 750  TMDSQMLASSTMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATS 809
            T   ++L  S ++S   +T  M S      S  S  L++     +  + S  D Q   T 
Sbjct: 454  TKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQSSLTH 513

Query: 810  SMDSQMLATSSMDSQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLATSSMDSQMLASG 869
            S      + S   S    +S   +   ++S   S+  + S+  S     +S   +  AS 
Sbjct: 514  SSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKSPRKTASQ 573

Query: 870  TMDSQMLASGTMDAQMLASGTMDAQMLASSTQDSAMLGSKSPDPYRLAQDPYRLAQDPYR 929
              +++ + +  + A M  +  +  Q + +       L S SP P R     ++  Q P++
Sbjct: 574  LSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPL-SDSPPPSR-----WKPGQKPWK 627

Query: 930  LGHDPYR--LGHDAYRLG-QDPYRLGHDPYRLTPDPYRMSPRPYRIAPRSY-RIAPRPYR 985
              ++  +       + L  Q  Y L +     +   Y    +       +Y + + R   
Sbjct: 628  PSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSE 687

Query: 986  LAPRPLMLASR-RSMMMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSA 1044
             +PR    +SR RS   SY   RS+ SS+ RS     RS  S    R+  S + +   S+
Sbjct: 688  SSPRSRSRSSRSRSYSRSYTRSRSLASSHSRS-----RSPSSRSHSRNKYSDHSQCSRSS 742

Query: 1045 YERSMMSP---MAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADRSMMSSYSAADR 1101
               S+ S     A+R + S+ +++ +S  + S  S     S    G DRS      +  R
Sbjct: 743  SYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESR 802

Query: 1102 SMMSSYSAADRSMMSS 1117
            S +   S +++S + +
Sbjct: 803  SSLDYSSDSEQSSVQA 818



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 81/395 (20%), Positives = 144/395 (36%), Gaps = 42/395 (10%)

Query: 17   FREIQQELSSGRNEGQLNGETNTPIEGNQAGDAAASARSLPNEEIVQKIEEVLSGVLDTE 76
            ++  +Q  S+  +EG  +   N    G        S  +L  E   +K++E L G  D +
Sbjct: 948  WKSSKQRTSTSDSEGSCSNSENN--RGKPQKHKHGSKENLKREH-TKKVKEKLKGKKDKK 1004

Query: 77   LRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEES 136
             +  P  K+       +    +  +EI  K+  +  K K   +  +  K+   K +    
Sbjct: 1005 HK-APKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSE 1063

Query: 137  ESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEV 196
            E  +  HD   +  + D F K DS+ S            P+  N    V     +  +E 
Sbjct: 1064 EDLSGKHDTVTVSSDLDQFTKDDSKLS----------ISPTALNTEENVACLQNIQHVEE 1113

Query: 197  SEPHILETLKPATKTAELSV---VSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTT 253
            S P+ +E +       E+      S + + E S    A +  P +  +L    A   P  
Sbjct: 1114 SVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQA 1173

Query: 254  TLVLKS---SEPVVTMSVEYQ---MKSVLKSVESTS----PEPSKIMLVEPPVAKVLEPS 303
             +V +    SE  V   V  Q     S+  + EST      E S+I L++    K L+  
Sbjct: 1174 EVVKQESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINLIDKK-WKPLQGV 1232

Query: 304  ETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMTRPQEL-P 362
              L           P  +TS+ ++    + +  ++    P  +  EI   +  RP  L  
Sbjct: 1233 GNLAA---------PNAATSSAVEVKVLTTVPEMK----PQGLRIEIKSKNKVRPGSLFD 1279

Query: 363  ELPKTTALELQESSVASAMELPGPPATSMPELQGP 397
            E+ KT  L  +  +  S+ +   P      + + P
Sbjct: 1280 EVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSP 1314



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 53/216 (24%), Positives = 79/216 (36%), Gaps = 20/216 (9%)

Query: 1846 RARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERK 1905
            + RK+ + S+   S + S S S     S     +SR R+   + K KRS K R ++   +
Sbjct: 187  KKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSE 246

Query: 1906 RKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSR 1965
              R+    N K    RS T  +RS     S  +R + V R     I P   +R   RR  
Sbjct: 247  EPRNKHAMNPKGHSERSDTNEKRS---VDSSAKREKPVVRPE--EIPPVPENRFLLRRDM 301

Query: 1966 TPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLR------- 2018
                    P      P    + PS       R+ + R  +R      +P R R       
Sbjct: 302  PVVTAEPEPKIPDVAPIVSDQKPS--VSKSGRKIKGRGTIRYH----TPPRSRSCSESDD 355

Query: 2019 --RSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTD 2052
               S TP   +     +R  R  S E+     +L+D
Sbjct: 356  DDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSD 391



 Score = 39.3 bits (90), Expect = 0.045
 Identities = 35/109 (32%), Positives = 48/109 (44%), Gaps = 11/109 (10%)

Query: 1833 EHKSRKRT-SESRSRARKRSSKSKSHRSQTRSRSRSRRR---RRSSRSRSKSRGRRSVSK 1888
            E K +K T SE    +   SS S+S         RSRRR   RR    RSK R + + S 
Sbjct: 186  EKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSS 245

Query: 1889 E----KRKRSPK---HRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSR 1930
            E    K   +PK    RS + E++   SS++  +  VR     P   +R
Sbjct: 246  EEPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENR 294



 Score = 35.8 bits (81), Expect = 0.50
 Identities = 37/182 (20%), Positives = 64/182 (35%), Gaps = 5/182 (2%)

Query: 1955 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISP 2014
            ++ + P+    + S  + + S  S + S      SRR +   R +  RS  RR+  S S 
Sbjct: 187  KKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSE 246

Query: 2015 VRLRRSRTPLRRRFSRSPIRRKRSRSSERGRS-----PKRLTDLDKAQLLEIAKANAAAM 2069
                +     +    RS    KRS  S   R      P+ +  + + + L          
Sbjct: 247  EPRNKHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTA 306

Query: 2070 CAKAGVPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVS 2129
              +  +P    +     P++ +   K  G  TI   T    +     +DDD     PH  
Sbjct: 307  EPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWK 366

Query: 2130 DE 2131
            +E
Sbjct: 367  EE 368



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 2/88 (2%)

Query: 78  RYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSK-KHKKHKNKKKKKKKEKEKKYKRQPEES 136
           R KP   EGS  S   S  ++ + E   +  + + +KHK + K K+ +K +K     EE 
Sbjct: 189 RKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEP 248

Query: 137 ESKTKSHDDGNIDLESDSFLKFDSEPSA 164
            +K   +  G+ +  SD+  K   + SA
Sbjct: 249 RNKHAMNPKGHSE-RSDTNEKRSVDSSA 275



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 35/117 (29%), Positives = 57/117 (48%), Gaps = 11/117 (9%)

Query: 1036 AYERSM-MSAYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMADRSMMSMGADRSMMS 1094
            +YER   M A    ++   +  S+ +  E    S+Y +   +  +D+S  S  +DRS  S
Sbjct: 629  SYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSES 688

Query: 1095 SYSAADRSMMS-SYSAA---DRSMMSSYTADR--SMMSMAADSYTD----SYTDTYT 1141
            S  +  RS  S SYS +    RS+ SS++  R  S  S + + Y+D    S + +YT
Sbjct: 689  SPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYT 745



 Score = 32.0 bits (71), Expect = 7.2
 Identities = 19/60 (31%), Positives = 30/60 (50%)

Query: 82  DLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTK 141
           D +  S++SR  S     +D    + S  HKK + +KK K K+K KK K      ++K +
Sbjct: 398 DERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQTKKR 457


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 136/477 (28%), Positives = 205/477 (42%), Gaps = 55/477 (11%)

Query: 1700 ESSGGEKEVPPPPKETLPDS--GFSANIED----INEADLVRPLLPKDMERLT----SLR 1749
            E  GG+K+       TL  S  G S+N  +    +++    +    KDM  +T    SL 
Sbjct: 5    ERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLG 64

Query: 1750 AGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKD-THEKSKKNKN 1808
              I+  +   D+  D    S  ++   +R         D  +   K +   H +S+    
Sbjct: 65   TVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLK 124

Query: 1809 RDKGEKEKKRDSSLRSRSKRSK---SSEHKSRKRTSESRSRARKRSSK----SKSHRSQT 1861
              + EKEK ++ S +S S + +   SS+  + +     +++  K SSK    SK H+ +T
Sbjct: 125  AKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKT 184

Query: 1862 RSRSRSRRRRRSSRSRSKSRGRRSVSKE-KRKRSPKHRSKSRERKRKRSSSRDNRKTVRA 1920
            R   + R  +   + RSKS  +R   K  K   SPK RS+S  RK   SS +D+  +  +
Sbjct: 185  R---KERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGAS 241

Query: 1921 RSRTPSRR-SRSHTPSR----RRRSRSVGRRRSFSISPSRRSRTPSRRSRTPS-----RR 1970
              +      SRSHT S     ++   S  RR+S S  P +        +R+PS     +R
Sbjct: 242  YGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVS-PPYKEPSAYQSSTRSPSPYSRRQR 300

Query: 1971 SRTP-SRRSRTPSRRSRTPSRRSRTPSRRRRSRS-VVRRRSFSISPVRLR-----RSRTP 2023
            S +P SRR  +   RS + S RS +P  RRRS S  + +RS S SP+  R     RSR+P
Sbjct: 301  SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 360

Query: 2024 LRRRFSRSPIRRKR--SRSSERGRSPKRL-------TDLDKAQLLEIAKANAAAMCAKAG 2074
               R S S  ++KR  SRS     SP RL        +L + +    A A AA M  K  
Sbjct: 361  AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 420

Query: 2075 VPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDE 2131
               P  L    P      V  K  G   ++L    K   +    D  +VN  H++ E
Sbjct: 421  KGSPVFL----PRKENSSVEAKDSGLESKKLPRSVK--LEKSAPDTELVNVTHLNTE 471



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 84/361 (23%), Positives = 133/361 (36%), Gaps = 67/361 (18%)

Query: 959  TPDPY--RMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERS 1016
            +P PY  R S  P+ ++ RS   +P P R + +       RS   +Y+   S  S  +RS
Sbjct: 323  SPSPYGRRRSSSPF-LSKRSLSRSPLPSRKSMKS------RSRSPAYSRHSSSHSKKKRS 375

Query: 1017 MMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMS 1076
                  S +SP+      S          ER+  +  A+     +    +    + +   
Sbjct: 376  SSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSV 435

Query: 1077 PMADRSMMSMGADRSMMSSYSAADRSMMS----------------------SYSAADRSM 1114
               D  + S    RS+    SA D  +++                      S     + +
Sbjct: 436  EAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDL 495

Query: 1115 MSSYTADRSMMSMAADSYTDSYTDTY---------TEAYMVPPLPPEEPPTM-PPLPPEE 1164
             +  T D   +++  +  T   T+T          T A   PPLP   PP   PPLPP  
Sbjct: 496  KAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLP 555

Query: 1165 P----PMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEI 1220
            P    P  PPLPP +P       +  S L      P+    + +  S +  +PPV  S  
Sbjct: 556  PIPALPQQPPLPPSQPAFSQVPASSTSTLP-----PSTHSKTSAVSSQANSQPPVQVS-- 608

Query: 1221 SEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERP 1280
                 V T  SV+A+ P +  S    T+P  P  P     L P +  + + + E +P +P
Sbjct: 609  -----VKTQVSVTAAIPHLKTS----TLPPLPLPP-----LLPGDDDMDSPK-ETLPSKP 653

Query: 1281 V 1281
            V
Sbjct: 654  V 654



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 120/615 (19%), Positives = 209/615 (33%), Gaps = 96/615 (15%)

Query: 18  REIQQELSS--GRNEGQLNGETNTPIEGNQAGDAAASARSLPNEEIVQKIEEVLSGVLDT 75
           +E  QE+SS  G  + +++G +    E       A  A+S   E    K+ +        
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHK-------E 182

Query: 76  ELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEE 135
           + R + +LK G +                  +SK H+K +  K  K  +  K+  R P  
Sbjct: 183 KTRKERELKSGHKD-----------------RSKSHRKRETPKSYKTVDSPKRRSRSPHR 225

Query: 136 SESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAV---VLEPPVV 192
             S +   DD                 S  +    +    P  T+   +V     EP   
Sbjct: 226 KWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAY 285

Query: 193 SMEVSEPHILE----TLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAA 248
                 P        ++ P ++    S   +   S +S          S      S + +
Sbjct: 286 QSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRS 345

Query: 249 PVPTT-TLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIML-VEPPVAKVLEPSETL 306
           P+P+  ++  +S  P  +       K    S  S     S + L +   +   L   +  
Sbjct: 346 PLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKE 405

Query: 307 VVSSETPTEVYPEPSTSTTMDFP---------ESSAIEALRLPEQPVDVPSEIADSSMTR 357
             ++    ++  + S  + +  P         + S +E+ +LP   V +     D+ +  
Sbjct: 406 RAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS-VKLEKSAPDTELVN 464

Query: 358 PQELPELPKTTA----LELQESS------------------VASAMELPGPPATSMPELQ 395
              L    K ++    ++L E+S                  +A   E+  P  T   E +
Sbjct: 465 VTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKE 524

Query: 396 GPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTPVPQLSQELPG 455
            PP  P +  P P   P+P    P  TP P  P PP  A+P+ P     P+P        
Sbjct: 525 TPPPLPTIASPPP---PLPTTTPPPQTP-PLPPLPPIPALPQQP-----PLPPSQPAFSQ 575

Query: 456 LPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQ 515
           +PA S    PP    +   ++ +    P V  +V+   Q +VT A+     P   T    
Sbjct: 576 VPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVK--TQVSVTAAI-----PHLKTSTLP 628

Query: 516 PVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALELPGQPSVTGVPELPGL 575
           P+ +        P +      +  P+ T    LP +PV     E   +  +T +P  P L
Sbjct: 629 PLPL--------PPLLPGDDDMDSPKET----LPSKPVKKEK-EQRTRHLLTDLPLPPEL 675

Query: 576 PSATRALELSGQPVA 590
           P    +   S +P A
Sbjct: 676 PGGDLSPPDSPEPKA 690



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 85/400 (21%), Positives = 145/400 (36%), Gaps = 69/400 (17%)

Query: 105 TKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSA 164
           +K+S       ++K  K + +   Y R       K +S                 S  S 
Sbjct: 338 SKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSR-----------HSSISP 386

Query: 165 VALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISE 224
           V L L + + G   + +            M+  E        P  + + +    + + S+
Sbjct: 387 VRLPLNS-SLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESK 445

Query: 225 QSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSP 284
           +  +SV +      T++++          T V  SS+       E   K ++K +++   
Sbjct: 446 KLPRSVKLEKSAPDTELVNV-----THLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGT 500

Query: 285 EPSKIMLVEPPVAKVLEPSETLVVSSETP----TEVYPEPSTSTTMDFPESSAIEAL--- 337
             SK + ++    +++ P ET     ETP    T   P P   TT   P++  +  L   
Sbjct: 501 RDSKPIALKE---EIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPI 557

Query: 338 -RLPEQPVDVPSEIADSSMTRPQELPELP----KTTALELQESS-----------VASAM 381
             LP+QP   PS+ A S +         P    KT+A+  Q +S           V+   
Sbjct: 558 PALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTA 617

Query: 382 ELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPV----------------- 424
            +P    +++P L  PP+     LPG      P+   P S PV                 
Sbjct: 618 AIPHLKTSTLPPLPLPPL-----LPGDDDMDSPKETLP-SKPVKKEKEQRTRHLLTDLPL 671

Query: 425 -PELPGPPATAVPELPGP-SVTPVPQLSQELPGLPAPSMG 462
            PELPG   +  P+ P P ++TP  Q  ++ P +  P  G
Sbjct: 672 PPELPGGDLSP-PDSPEPKAITPPQQPYKKRPKICCPRYG 710



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 64/277 (23%), Positives = 107/277 (38%), Gaps = 25/277 (9%)

Query: 207  PATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFA-AAPVPTTTLVLKSSEPVVT 265
            P +KT+     S    +E  + S    P+P+  K+      A  +   T  L  SE  V 
Sbjct: 1061 PPSKTSRKETTS-GTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVL 1119

Query: 266  MSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTT 325
            +++      +    + + P+ ++++ +     ++ +  E L  S    TE   +   S T
Sbjct: 1120 LNL------LQSQTDLSIPQMAQLLNIHSN-PEMQQQLEALNQSISALTEATSQQQDSET 1172

Query: 326  MDFPESSAIEALRLPEQPVDVPS--EIADSSMTRPQELPELPKTTALELQESSV-ASAME 382
            M  PE S  EA   P  PV +PS  +    + + P ++  +      +L ++   A ++E
Sbjct: 1173 MA-PEESLKEA---PSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLE 1228

Query: 383  LPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVP------ELPGPPATAVP 436
                   S P  QGP  TP +     +    PE PGP   P P      +L   P    P
Sbjct: 1229 ENNSDKNSGP--QGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNP 1286

Query: 437  ELPGPSVTPVPQLSQELPG-LPAPSMGLEPPQEVPEP 472
             +    +  + Q   E PG LP     L P +    P
Sbjct: 1287 AVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRP 1323



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 101/478 (21%), Positives = 179/478 (37%), Gaps = 68/478 (14%)

Query: 1006 ERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAY--- 1062
            ER + S ++    S+ R   +P + +++ S   RS     + S  S   +    ++Y   
Sbjct: 187  ERELKSGHKDRSKSH-RKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQD 245

Query: 1063 -----ERSMMSA-YERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMS 1116
                  RS  S+ Y+    SP +     S+       S+Y ++ RS  S YS   RS+ S
Sbjct: 246  YDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSP-SPYSRRQRSV-S 303

Query: 1117 SYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEP 1176
             Y+  RS     + SY+      Y       P   +   +  PLP  +   +    P   
Sbjct: 304  PYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPA-- 361

Query: 1177 PEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASD 1236
                      S  ++ ++      S     S+S    P++ S  +E S    + + +A+ 
Sbjct: 362  ---------YSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAA 412

Query: 1237 PSVLVSEAAVTVPEPPPEPESSITL--TPVESAVVAEEHEVVPERPVTCMVSETPAMSAE 1294
              +   E+  +    P +  SS+    + +ES  +    ++    P T +V+ T      
Sbjct: 413  AKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTH----- 467

Query: 1295 PTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPES 1354
               L +E    S+T +      +  H+  ++                      A    +S
Sbjct: 468  ---LNTEVKNSSDTGKVKLDENSEKHLVKDLK---------------------AQGTRDS 503

Query: 1355 SAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSAL- 1413
              +A L+   VT  E+ T    E  T   L P++ + P P     P   T P+P +  + 
Sbjct: 504  KPIA-LKEEIVTPKETETS---EKETPPPL-PTIASPPPPLPTTTPPPQTPPLPPLPPIP 558

Query: 1414 ----EPSVPVLEPAVSVLQPSMIVS-EPSVSVQESTVTV---SEPAVTVSEQTQVIPT 1463
                +P +P  +PA S +  S   +  PS   + S V+    S+P V VS +TQV  T
Sbjct: 559  ALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVT 616



 Score = 31.6 bits (70), Expect = 9.4
 Identities = 21/67 (31%), Positives = 30/67 (44%), Gaps = 3/67 (4%)

Query: 1151 PEEPPTMPPLPPEE-PPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVS 1209
            P+ P   P +P EE     PP PP  PP  P  P  +  L++         ++   + +S
Sbjct: 1238 PQGPRRTPTMPQEEAAEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLS 1297

Query: 1210 QP--EPP 1214
            QP  EPP
Sbjct: 1298 QPEAEPP 1304


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score = 99.4 bits (246), Expect = 4e-20
 Identities = 136/477 (28%), Positives = 205/477 (42%), Gaps = 55/477 (11%)

Query: 1700 ESSGGEKEVPPPPKETLPDS--GFSANIED----INEADLVRPLLPKDMERLT----SLR 1749
            E  GG+K+       TL  S  G S+N  +    +++    +    KDM  +T    SL 
Sbjct: 5    ERHGGKKDGSGGASGTLQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLG 64

Query: 1750 AGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKD-THEKSKKNKN 1808
              I+  +   D+  D    S  ++   +R         D  +   K +   H +S+    
Sbjct: 65   TVIKPLVEYDDISSDSDTFSDDMAFKLDRRENDERRGSDRSDRLHKHRHHQHRRSRDLLK 124

Query: 1809 RDKGEKEKKRDSSLRSRSKRSK---SSEHKSRKRTSESRSRARKRSSK----SKSHRSQT 1861
              + EKEK ++ S +S S + +   SS+  + +     +++  K SSK    SK H+ +T
Sbjct: 125  AKQTEKEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKT 184

Query: 1862 RSRSRSRRRRRSSRSRSKSRGRRSVSKE-KRKRSPKHRSKSRERKRKRSSSRDNRKTVRA 1920
            R   + R  +   + RSKS  +R   K  K   SPK RS+S  RK   SS +D+  +  +
Sbjct: 185  R---KERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGAS 241

Query: 1921 RSRTPSRR-SRSHTPSR----RRRSRSVGRRRSFSISPSRRSRTPSRRSRTPS-----RR 1970
              +      SRSHT S     ++   S  RR+S S  P +        +R+PS     +R
Sbjct: 242  YGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVS-PPYKEPSAYQSSTRSPSPYSRRQR 300

Query: 1971 SRTP-SRRSRTPSRRSRTPSRRSRTPSRRRRSRS-VVRRRSFSISPVRLR-----RSRTP 2023
            S +P SRR  +   RS + S RS +P  RRRS S  + +RS S SP+  R     RSR+P
Sbjct: 301  SVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSP 360

Query: 2024 LRRRFSRSPIRRKR--SRSSERGRSPKRL-------TDLDKAQLLEIAKANAAAMCAKAG 2074
               R S S  ++KR  SRS     SP RL        +L + +    A A AA M  K  
Sbjct: 361  AYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKES 420

Query: 2075 VPLPPNLKPAPPPTIEEKVAKKSGGATIEELTEKCKQIAQSKEDDDVIVNKPHVSDE 2131
               P  L    P      V  K  G   ++L    K   +    D  +VN  H++ E
Sbjct: 421  KGSPVFL----PRKENSSVEAKDSGLESKKLPRSVK--LEKSAPDTELVNVTHLNTE 471



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 84/361 (23%), Positives = 133/361 (36%), Gaps = 67/361 (18%)

Query: 959  TPDPY--RMSPRPYRIAPRSYRIAPRPYRLAPRPLMLASRRSMMMSYAAERSMMSSYERS 1016
            +P PY  R S  P+ ++ RS   +P P R + +       RS   +Y+   S  S  +RS
Sbjct: 323  SPSPYGRRRSSSPF-LSKRSLSRSPLPSRKSMKS------RSRSPAYSRHSSSHSKKKRS 375

Query: 1017 MMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYERSMMSAYERSMMS 1076
                  S +SP+      S          ER+  +  A+     +    +    + +   
Sbjct: 376  SSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSV 435

Query: 1077 PMADRSMMSMGADRSMMSSYSAADRSMMS----------------------SYSAADRSM 1114
               D  + S    RS+    SA D  +++                      S     + +
Sbjct: 436  EAKDSGLESKKLPRSVKLEKSAPDTELVNVTHLNTEVKNSSDTGKVKLDENSEKHLVKDL 495

Query: 1115 MSSYTADRSMMSMAADSYTDSYTDTY---------TEAYMVPPLPPEEPPTM-PPLPPEE 1164
             +  T D   +++  +  T   T+T          T A   PPLP   PP   PPLPP  
Sbjct: 496  KAQGTRDSKPIALKEEIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLP 555

Query: 1165 P----PMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEI 1220
            P    P  PPLPP +P       +  S L      P+    + +  S +  +PPV  S  
Sbjct: 556  PIPALPQQPPLPPSQPAFSQVPASSTSTLP-----PSTHSKTSAVSSQANSQPPVQVS-- 608

Query: 1221 SEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVESAVVAEEHEVVPERP 1280
                 V T  SV+A+ P +  S    T+P  P  P     L P +  + + + E +P +P
Sbjct: 609  -----VKTQVSVTAAIPHLKTS----TLPPLPLPP-----LLPGDDDMDSPK-ETLPSKP 653

Query: 1281 V 1281
            V
Sbjct: 654  V 654



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 120/615 (19%), Positives = 209/615 (33%), Gaps = 96/615 (15%)

Query: 18  REIQQELSS--GRNEGQLNGETNTPIEGNQAGDAAASARSLPNEEIVQKIEEVLSGVLDT 75
           +E  QE+SS  G  + +++G +    E       A  A+S   E    K+ +        
Sbjct: 130 KEKSQEVSSKSGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHK-------E 182

Query: 76  ELRYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEE 135
           + R + +LK G +                  +SK H+K +  K  K  +  K+  R P  
Sbjct: 183 KTRKERELKSGHKD-----------------RSKSHRKRETPKSYKTVDSPKRRSRSPHR 225

Query: 136 SESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAV---VLEPPVV 192
             S +   DD                 S  +    +    P  T+   +V     EP   
Sbjct: 226 KWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAY 285

Query: 193 SMEVSEPHILE----TLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAA 248
                 P        ++ P ++    S   +   S +S          S      S + +
Sbjct: 286 QSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRS 345

Query: 249 PVPTT-TLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIML-VEPPVAKVLEPSETL 306
           P+P+  ++  +S  P  +       K    S  S     S + L +   +   L   +  
Sbjct: 346 PLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKE 405

Query: 307 VVSSETPTEVYPEPSTSTTMDFP---------ESSAIEALRLPEQPVDVPSEIADSSMTR 357
             ++    ++  + S  + +  P         + S +E+ +LP   V +     D+ +  
Sbjct: 406 RAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRS-VKLEKSAPDTELVN 464

Query: 358 PQELPELPKTTA----LELQESS------------------VASAMELPGPPATSMPELQ 395
              L    K ++    ++L E+S                  +A   E+  P  T   E +
Sbjct: 465 VTHLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGTRDSKPIALKEEIVTPKETETSEKE 524

Query: 396 GPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSVTPVPQLSQELPG 455
            PP  P +  P P   P+P    P  TP P  P PP  A+P+ P     P+P        
Sbjct: 525 TPPPLPTIASPPP---PLPTTTPPPQTP-PLPPLPPIPALPQQP-----PLPPSQPAFSQ 575

Query: 456 LPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTTELEQ 515
           +PA S    PP    +   ++ +    P V  +V+   Q +VT A+     P   T    
Sbjct: 576 VPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVK--TQVSVTAAI-----PHLKTSTLP 628

Query: 516 PVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALELPGQPSVTGVPELPGL 575
           P+ +        P +      +  P+ T    LP +PV     E   +  +T +P  P L
Sbjct: 629 PLPL--------PPLLPGDDDMDSPKET----LPSKPVKKEK-EQRTRHLLTDLPLPPEL 675

Query: 576 PSATRALELSGQPVA 590
           P    +   S +P A
Sbjct: 676 PGGDLSPPDSPEPKA 690



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 85/400 (21%), Positives = 145/400 (36%), Gaps = 69/400 (17%)

Query: 105 TKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSA 164
           +K+S       ++K  K + +   Y R       K +S                 S  S 
Sbjct: 338 SKRSLSRSPLPSRKSMKSRSRSPAYSRHSSSHSKKKRSSSRSR-----------HSSISP 386

Query: 165 VALELPTRAFGPSETNESPAVVLEPPVVSMEVSEPHILETLKPATKTAELSVVSTSVISE 224
           V L L + + G   + +            M+  E        P  + + +    + + S+
Sbjct: 387 VRLPLNS-SLGAELSRKKKERAAAAAAAKMDGKESKGSPVFLPRKENSSVEAKDSGLESK 445

Query: 225 QSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSP 284
           +  +SV +      T++++          T V  SS+       E   K ++K +++   
Sbjct: 446 KLPRSVKLEKSAPDTELVNV-----THLNTEVKNSSDTGKVKLDENSEKHLVKDLKAQGT 500

Query: 285 EPSKIMLVEPPVAKVLEPSETLVVSSETP----TEVYPEPSTSTTMDFPESSAIEAL--- 337
             SK + ++    +++ P ET     ETP    T   P P   TT   P++  +  L   
Sbjct: 501 RDSKPIALKE---EIVTPKETETSEKETPPPLPTIASPPPPLPTTTPPPQTPPLPPLPPI 557

Query: 338 -RLPEQPVDVPSEIADSSMTRPQELPELP----KTTALELQESS-----------VASAM 381
             LP+QP   PS+ A S +         P    KT+A+  Q +S           V+   
Sbjct: 558 PALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVTA 617

Query: 382 ELPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPV----------------- 424
            +P    +++P L  PP+     LPG      P+   P S PV                 
Sbjct: 618 AIPHLKTSTLPPLPLPPL-----LPGDDDMDSPKETLP-SKPVKKEKEQRTRHLLTDLPL 671

Query: 425 -PELPGPPATAVPELPGP-SVTPVPQLSQELPGLPAPSMG 462
            PELPG   +  P+ P P ++TP  Q  ++ P +  P  G
Sbjct: 672 PPELPGGDLSP-PDSPEPKAITPPQQPYKKRPKICCPRYG 710



 Score = 40.8 bits (94), Expect = 0.016
 Identities = 70/276 (25%), Positives = 113/276 (40%), Gaps = 31/276 (11%)

Query: 207  PATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFA-AAPVPTTTLVLKSSEPVVT 265
            P +KT+     S    +E  + S    P+P+  K+      A  +   T  L  SE  V 
Sbjct: 1061 PPSKTSRKETTS-GTSTEPVKNSSPAPPQPAPGKVESGAGDAIGLADITQQLNQSELAVL 1119

Query: 266  MSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTT 325
            +++      +    + + P+ ++++ +     ++ +  E L  S    TE   +   S T
Sbjct: 1120 LNL------LQSQTDLSIPQMAQLLNIHSN-PEMQQQLEALNQSISALTEATSQQQDSET 1172

Query: 326  MDFPESSAIEALRLPEQPVDVPS--EIADSSMTRPQELPELPKTTALELQESSV-ASAME 382
            M  PE S  EA   P  PV +PS  +    + + P ++  +      +L ++   A ++E
Sbjct: 1173 MA-PEESLKEA---PSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMKTQEPAGSLE 1228

Query: 383  LPGPPATSMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPS 442
                   S P  QGP  TP +     +A P P +  P   P PE PGPP    P  P P 
Sbjct: 1229 ENNSDKNSGP--QGPRRTPTMPQEEAAACP-PHILPPEKRP-PEPPGPPP---PPPPPPL 1281

Query: 443  VT-PVPQLSQEL-PGLPAPSMGL------EPPQEVP 470
            V   +    QEL P + A  + L      EPP  +P
Sbjct: 1282 VEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLP 1317



 Score = 40.0 bits (92), Expect = 0.027
 Identities = 20/48 (41%), Positives = 25/48 (52%), Gaps = 2/48 (4%)

Query: 1147 PPLPPEEPPTMPP--LPPEEPPMTPPLPPEEPPEGPALPTEQSALTAE 1192
            P +P EE    PP  LPPE+ P  PP PP  PP  P +  + S+   E
Sbjct: 1245 PTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQE 1292



 Score = 36.2 bits (82), Expect = 0.38
 Identities = 101/478 (21%), Positives = 179/478 (37%), Gaps = 68/478 (14%)

Query: 1006 ERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAY--- 1062
            ER + S ++    S+ R   +P + +++ S   RS     + S  S   +    ++Y   
Sbjct: 187  ERELKSGHKDRSKSH-RKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQD 245

Query: 1063 -----ERSMMSA-YERSMMSPMADRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMS 1116
                  RS  S+ Y+    SP +     S+       S+Y ++ RS  S YS   RS+ S
Sbjct: 246  YDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEPSAYQSSTRSP-SPYSRRQRSV-S 303

Query: 1117 SYTADRSMMSMAADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEP 1176
             Y+  RS     + SY+      Y       P   +   +  PLP  +   +    P   
Sbjct: 304  PYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPLPSRKSMKSRSRSPA-- 361

Query: 1177 PEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASD 1236
                      S  ++ ++      S     S+S    P++ S  +E S    + + +A+ 
Sbjct: 362  ---------YSRHSSSHSKKKRSSSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAA 412

Query: 1237 PSVLVSEAAVTVPEPPPEPESSITL--TPVESAVVAEEHEVVPERPVTCMVSETPAMSAE 1294
              +   E+  +    P +  SS+    + +ES  +    ++    P T +V+ T      
Sbjct: 413  AKMDGKESKGSPVFLPRKENSSVEAKDSGLESKKLPRSVKLEKSAPDTELVNVTH----- 467

Query: 1295 PTVLASEPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPES 1354
               L +E    S+T +      +  H+  ++                      A    +S
Sbjct: 468  ---LNTEVKNSSDTGKVKLDENSEKHLVKDLK---------------------AQGTRDS 503

Query: 1355 SAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSAL- 1413
              +A L+   VT  E+ T    E  T   L P++ + P P     P   T P+P +  + 
Sbjct: 504  KPIA-LKEEIVTPKETETS---EKETPPPL-PTIASPPPPLPTTTPPPQTPPLPPLPPIP 558

Query: 1414 ----EPSVPVLEPAVSVLQPSMIVS-EPSVSVQESTVTV---SEPAVTVSEQTQVIPT 1463
                +P +P  +PA S +  S   +  PS   + S V+    S+P V VS +TQV  T
Sbjct: 559  ALPQQPPLPPSQPAFSQVPASSTSTLPPSTHSKTSAVSSQANSQPPVQVSVKTQVSVT 616



 Score = 32.0 bits (71), Expect = 7.2
 Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 3/36 (8%)

Query: 1151 PEEPPTMPPLPPEEPPMTPP--LPPEE-PPEGPALP 1183
            P+ P   P +P EE    PP  LPPE+ PPE P  P
Sbjct: 1238 PQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPP 1273


>gi|221139764 PHD and ring finger domains 1 [Homo sapiens]
          Length = 1648

 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 120/389 (30%), Positives = 169/389 (43%), Gaps = 46/389 (11%)

Query: 1722 SANIEDINEADLVRPLLPKDMERLTSLRAGI--EGPLLASDVGRDRSAASPVVSSMPERA 1779
            S  +E I   +   PL P     ++ LR  +  EG   ASD  R+    S  +++   R 
Sbjct: 880  SYTVESIFGTEPEPPLGPSSA--MSKLRGAVAAEG---ASDTEREEPTESQGLAARLRRP 934

Query: 1780 SESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKR 1839
            S     +++D         + E++       + E     D  L++ + R       SR R
Sbjct: 935  SPPEPWDEEDGASCSTFFGSEERTVTCVTVVEPEAPPSPDV-LQAATHRVVELRPPSRSR 993

Query: 1840 -TSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRG----RRSVSKEKRKRS 1894
             TS SRSR + +  +      +TRS +RS  R RSSRS S S G    RR  SK K +RS
Sbjct: 994  STSSSRSRKKAKRKRVSREHGRTRSGTRSESRDRSSRSASPSVGEERPRRQRSKAKSRRS 1053

Query: 1895 PKHRSKSRER-KRKRSSSRD----------NRKTVRARSRTPSRRSRSHTPSRRRRS-RS 1942
               RS SRER KRK++  +           +R+T R+RS +P   S  H  SR+++  RS
Sbjct: 1054 SSDRSSSRERAKRKKAKDKSREHRRGPWGHSRRTSRSRSGSPGSSSYEHYESRKKKKRRS 1113

Query: 1943 VGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSR 2002
              R R    SP+       R      R    P R+      R R   RRSR+PS   R+R
Sbjct: 1114 ASRPRGRECSPTSSLERLCRHKHQRERSHERPDRKESVAWPRDRR-KRRSRSPSSEHRAR 1172

Query: 2003 SVVRRRSFSISPVRLRRSRTPLR----RRFSRSPIRRKRSRSSERGRS--PKRLTDLDKA 2056
               R RS    P    RS +P R    R  S +P+ +      E GR   P RL  L +A
Sbjct: 1173 EHRRPRSREKWP--QTRSHSPERKGAVREASPAPLAQ-----GEPGREDLPTRLPALGEA 1225

Query: 2057 QLL-EIAKANAAAMCAKAGVPLPPNLKPA 2084
             +  E+A A+      KA +  PP L+ A
Sbjct: 1226 HVSPEVATAD------KAPLQAPPVLEVA 1248



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 43/138 (31%), Positives = 66/138 (47%), Gaps = 16/138 (11%)

Query: 1891 RKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRS------RSVG 1944
            R R+ + R+ +R R+ +R  +  NR      +R  + R   HTP R   S       +V 
Sbjct: 264  RPRAGRTRAIARTRQSERVRATVNR------NRISTARRVQHTPGRLGSSLLDEAIEAVA 317

Query: 1945 RRRSFSISPSRRS-RTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRS 2003
               S ++     + RTP+RR R   RR + P R+ +TPS  S   S+ S T S++R+ R 
Sbjct: 318  TGLSTAVYQRPLTPRTPARRKRKTRRRKKVPGRK-KTPSGPS-AKSKSSATRSKKRQHR- 374

Query: 2004 VVRRRSFSISPVRLRRSR 2021
            V +RR   +      RSR
Sbjct: 375  VKKRRGKKVKSEATTRSR 392



 Score = 34.7 bits (78), Expect = 1.1
 Identities = 57/233 (24%), Positives = 93/233 (39%), Gaps = 45/233 (19%)

Query: 1668 LPSNNNLVSKDTEEPLPVK---ESDQTLAALLSPKESSGGEKEVPPPPKETLP-DSGF-- 1721
            +P  N   S++ E+P   +    SD+    LL     +G   E   PP + +P D  F  
Sbjct: 169  IPVENTKASEEEEDPTFCEVCGRSDREDRLLLCDGCDAGYHMECLDPPLQEVPVDEWFCP 228

Query: 1722 ---------SANIEDINEADLVRPLLPKDMERLTSL---RAGI--------EGPLLASDV 1761
                     +A+   ++E ++   LL  D+   TS    RAG         +   + + V
Sbjct: 229  ECAAPGVVLAADAGPVSEEEV--SLLLADVVPTTSRLRPRAGRTRAIARTRQSERVRATV 286

Query: 1762 GRDRSAASPVVSSMPERASESSSEEKDD----------YEIFVKVKDTHEKSKKNKNRDK 1811
             R+R + +  V   P R   S  +E  +          Y+  +  +    + +K + R K
Sbjct: 287  NRNRISTARRVQHTPGRLGSSLLDEAIEAVATGLSTAVYQRPLTPRTPARRKRKTRRRKK 346

Query: 1812 GEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSR 1864
                KK  S     S +SKSS  +S+KR    + R +KR  K     + TRSR
Sbjct: 347  VPGRKKTPSG---PSAKSKSSATRSKKR----QHRVKKRRGKKVKSEATTRSR 392



 Score = 34.3 bits (77), Expect = 1.5
 Identities = 18/78 (23%), Positives = 38/78 (48%)

Query: 1822 LRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSR 1881
            L  R+   +  + + RK+    +      S+KSKS  ++++ R    ++RR  + +S++ 
Sbjct: 329  LTPRTPARRKRKTRRRKKVPGRKKTPSGPSAKSKSSATRSKKRQHRVKKRRGKKVKSEAT 388

Query: 1882 GRRSVSKEKRKRSPKHRS 1899
             R  +++    R P H S
Sbjct: 389  TRSRIARTLGLRRPVHSS 406



 Score = 33.5 bits (75), Expect = 2.5
 Identities = 24/79 (30%), Positives = 40/79 (50%), Gaps = 13/79 (16%)

Query: 1869 RRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRR 1928
            RR+R +R R K  GR+     K    P  +SKS       S++R  ++  R + R   ++
Sbjct: 336  RRKRKTRRRKKVPGRK-----KTPSGPSAKSKS-------SATRSKKRQHRVKKRR-GKK 382

Query: 1929 SRSHTPSRRRRSRSVGRRR 1947
             +S   +R R +R++G RR
Sbjct: 383  VKSEATTRSRIARTLGLRR 401


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
            sapiens]
          Length = 600

 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 74/309 (23%), Positives = 128/309 (41%), Gaps = 25/309 (8%)

Query: 1763 RDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKG-EKEKKRDSS 1821
            R+R+          +R +E  ++ K +     + KD H K  +++ R +  EKE++R + 
Sbjct: 54   RERNRQKERERRREKRQTERETDRKRERR---REKDRHRKRDRHRERQRDREKERERQTD 110

Query: 1822 L-RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKS 1880
              R R +  + +  K R+R +E R   R R  ++   R + R R   + R R +    + 
Sbjct: 111  RERDRQREKERNRQKERERETE-REGERGRDRQTDGQRERERQRDAEKERERQTDRERQR 169

Query: 1881 RGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRR-- 1938
            +  R+  KE+ +   +   + RER+R++ +  ++R + R R R   R + + T  +R+  
Sbjct: 170  QTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTD 229

Query: 1939 ------------RSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSR 1986
                        R +   R R+      R       R R   R  R   R  +T  +R R
Sbjct: 230  RERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289

Query: 1987 TPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRS 2046
               R   T  +R R R   R R  +      +R R   R R        +R R  ER R 
Sbjct: 290  RTERDRETERKRERQRERERERERN-----RKRERERERERERERQRETERDREKERERK 344

Query: 2047 PKRLTDLDK 2055
             KR T++D+
Sbjct: 345  RKRQTEMDR 353



 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 86/330 (26%), Positives = 141/330 (42%), Gaps = 24/330 (7%)

Query: 1740 KDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDT 1799
            K+ ER T  R G  G    +D  R+R           +R +E   E + D E   + +  
Sbjct: 125  KERERETE-REGERGRDRQTDGQRERER---------QRDAEKERERQTDRERQRQTERN 174

Query: 1800 HEKSK-KNKNR-DKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSH 1857
             +K + + KNR ++ E+E++R+   ++  + S+    + R+R +E+ +  ++++ + +  
Sbjct: 175  RQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDR 234

Query: 1858 RSQT-RSRSRSRRRRRSSR---SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRD 1913
            + +T R R +   R R+S     R K R R       R R  K R +  +RKR+R + RD
Sbjct: 235  QRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERD 294

Query: 1914 NRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSR-----RSRTPSRRSRTPS 1968
             R+T R R R   R        +R R R   R R       R     R R   R++    
Sbjct: 295  -RETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDR 353

Query: 1969 RRSRTPSRRSRTPSRRSRTPSR-RSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRR 2027
             R+R   R  R  + R R   R R R  +R R  R   R R       R +  +    +R
Sbjct: 354  ERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERER-QTEKDRDGQR 412

Query: 2028 FSRSPIRRKRSRSSERGRSPKRLTDLDKAQ 2057
             +     R++ R SERGR   R  +  K +
Sbjct: 413  ETEKQREREKDRESERGRERGREREKQKGR 442



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 80/300 (26%), Positives = 120/300 (40%), Gaps = 40/300 (13%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKG-----EKEKKRDSSLRSRSKRSKS 1831
            ER  E + +E+ + E         ++ K+NK  D+      E+E++R++   +  KR   
Sbjct: 178  EREREKNRQERRERE--------RQREKENKTEDRHSERGRERERERETETETERKRQTD 229

Query: 1832 SEHKSRKRTSESRS------RARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGR-- 1883
             E   +++T   R       RA +R ++    R + R R R R RR+  R R   R R  
Sbjct: 230  RERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289

Query: 1884 ---RSVSKEKRKRSPKHRSKSRERKRKRSSSRD-------NRKTVRARSRTPSRRSRSHT 1933
               R    E+++   + R + RER RKR   R+        R+T R R +   R+ +  T
Sbjct: 290  RTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQT 349

Query: 1934 PSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSR 1993
               R R+R  GR        + R R   R     S R R    R R    R R   R  +
Sbjct: 350  EMDRERNRQTGRE---GRRQAERERERERERDRQSAREREERERDRD---RDRQKERERQ 403

Query: 1994 TPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSER--GRSPKRLT 2051
            T   R   R   ++R          R R   R R  +    R R R ++R  GR  KR T
Sbjct: 404  TEKDRDGQRETEKQRERE-KDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRST 462



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 78/354 (22%), Positives = 140/354 (39%), Gaps = 48/354 (13%)

Query: 1733 LVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMPERASESSSEEKDDYEI 1792
            + + ++P   ++L +L   +  PL       D S   P     P R     + +  D + 
Sbjct: 1    MAKKIVPATADQLGTLWVEVTIPL-------DFSRRRPGSQESPRRRGLGQAHKDADGDD 53

Query: 1793 FVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSE-SRSRARKRS 1851
                ++ + + ++ + R+K + E++ D   R R +R +   H+ R R  E  R R ++R 
Sbjct: 54   ----RERNRQKERERRREKRQTERETD---RKRERRREKDRHRKRDRHRERQRDREKERE 106

Query: 1852 SKSKSHRSQTRSRSRSRRRRRSSRS-RSKSRGR---------------------RSVSKE 1889
             ++   R + R + R+R++ R   + R   RGR                     R   +E
Sbjct: 107  RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRE 166

Query: 1890 KRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRS--------RSHTPSRRRRSR 1941
            +++++ ++R K RER++ R   R+  +     ++T  R S           T +   R R
Sbjct: 167  RQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKR 226

Query: 1942 SVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRS 2001
               R R       R     + R R   R +     R R    R R   R  R   R R++
Sbjct: 227  QTDRERDRQRKTEREREKQAERERASERETERDKERER---ERDRDRDRDRRQKERERQT 283

Query: 2002 RSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDK 2055
                +RR+        +R R   R R      +R+R R  ER R  +R T+ D+
Sbjct: 284  DRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDR 337



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 74/298 (24%), Positives = 122/298 (40%), Gaps = 29/298 (9%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDK-------GEKEKKRDSSLRSRSKRS 1829
            +R  E   E + D E     +D   + ++N+ +++       GE+ + R +  +   +R 
Sbjct: 98   QRDREKERERQTDRE-----RDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQ 152

Query: 1830 KSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSR----GR-R 1884
            + +E +  ++T   R R  +R+ + +  R + R   R R R+R   ++++ R    GR R
Sbjct: 153  RDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRER 212

Query: 1885 SVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVG 1944
               +E    + + R   RER R+R + R+  K    R R   R +       R R R   
Sbjct: 213  ERERETETETERKRQTDRERDRQRKTEREREKQAE-RERASERETERDKERERERDRDRD 271

Query: 1945 RRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR-----RSRTPSRRSRTPSRRR 1999
            R R       R  +T  +R R   R   T  +R R   R     R+R   R       R 
Sbjct: 272  RDRR---QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE 328

Query: 2000 RSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSERGRSPKRLTDLDKAQ 2057
            R R   R R       R R+ +T + R  +R   R  R R +ER R  +R  D   A+
Sbjct: 329  RQRETERDREKERE--RKRKRQTEMDRERNRQTGREGR-RQAERERERERERDRQSAR 383



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 69/282 (24%), Positives = 116/282 (41%), Gaps = 23/282 (8%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKR--DSSLRSRSKRSKSSEH 1834
            ERASE  +E           K+   +  ++++RD+ +KE++R  D   + R++R + +E 
Sbjct: 249  ERASERETERD---------KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETER 299

Query: 1835 KSRKRTSESRSRARKRSSKSKSHRSQTRSRSRS--------RRRRRSSRSRSKSRGRRSV 1886
            K  ++    R R R R  + +  R + R R R         R R+R  ++       R  
Sbjct: 300  KRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQT 359

Query: 1887 SKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRR 1946
             +E R+++ + R + RER R+ +  R+ R+  R R R   R  ++      +R     R 
Sbjct: 360  GREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRE 419

Query: 1947 RSFSISPSRRSRTPSRRSRTPSRRSRTPSRRS-RTPSRRSRTPSRRSRTPSRRRRSRSVV 2005
            R      S R R   R       R R   R++ R   R+ +  +     P R  RS  V 
Sbjct: 420  RE-KDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQ 478

Query: 2006 RRRSFSISPVRLRRSRTPLRRRFSRSPIRR--KRSRSSERGR 2045
               +     +R + S    +   +R P  R  K SR    GR
Sbjct: 479  SDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGR 520



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 53/232 (22%), Positives = 94/232 (40%), Gaps = 30/232 (12%)

Query: 1777 ERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKS 1836
            ER  E+  + + + E   K +   ++ +  +   +G ++ +R+   R R +  +S+  + 
Sbjct: 328  ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERE-RERERDRQSARERE 386

Query: 1837 RKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRS-RSKSRGRRSVSKEKRKRSP 1895
             +     R R ++R  +++  R   R   + R R +   S R + RGR    K+K +   
Sbjct: 387  ERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRER-EKQKGRERD 445

Query: 1896 KHRSKSRE--RKRKRSSSRDNRKTVRARS----RTPSRRSRS------------------ 1931
            + R   R+  R+RKRS+   N     ARS      P+R +R                   
Sbjct: 446  RERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFP 505

Query: 1932 -HTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPS 1982
               P++  R R  GRRR       +R +      R PS    T +  S+ PS
Sbjct: 506  WGRPAKASRGRVAGRRRWEPRLGEKRGQ--GGEGRRPSGGFGTENPLSQAPS 555


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
            containing B [Homo sapiens]
          Length = 546

 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 64/191 (33%), Positives = 103/191 (53%), Gaps = 14/191 (7%)

Query: 1797 KDTHEKSKKNKNRDK---GEKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSK 1853
            K+     +++++ DK    E+EK+R+ S R RSK  +S      K+  E +   R R  K
Sbjct: 358  KENERGRRRDRDYDKERGNEREKERERS-RERSKEQRSRGEVEEKKHKEDKDDRRHRDDK 416

Query: 1854 SKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRD 1913
              S + +  SRSRSR R+  SRSRS++ G+RS S+ K K S KH+++S+E+  KRS S  
Sbjct: 417  RDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEK-SSKHKNESKEKSNKRSRSGS 475

Query: 1914 NRKTVRARSRTPSRRSRSHTPSR---RRRSRSVGR--RRSFSISPSRRSRTPSRRSRTPS 1968
              +T          + R H+PS+   R+RSRS  R  +R  S S  +  +   RRS++  
Sbjct: 476  QGRT----DSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIE 531

Query: 1969 RRSRTPSRRSR 1979
            + S+    +++
Sbjct: 532  QESQEKQHKNK 542



 Score = 94.7 bits (234), Expect = 9e-19
 Identities = 71/233 (30%), Positives = 108/233 (46%), Gaps = 20/233 (8%)

Query: 1813 EKEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRR 1872
            ++E +R+   +   + +K  E + R+  S  R   R+RS   + HRS++RSR R   RR 
Sbjct: 292  DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD 351

Query: 1873 SSRSRSKS--RGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSR 1930
              R R K   RGRR   ++  K     R K RER R+RS  + +R  V  +     +  R
Sbjct: 352  RDREREKENERGRRR-DRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDR 410

Query: 1931 SHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSR 1990
             H   +R   +     RS       RSR    RSR+   RSR   +RSR+ S+   +  +
Sbjct: 411  RHRDDKRDSKKEKKHSRS-------RSRERKHRSRS---RSRNAGKRSRSRSKEKSSKHK 460

Query: 1991 RSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSSER 2043
                    +RSRS  + R+ S+   + +R  +P + +       RKRSRS ER
Sbjct: 461  NESKEKSNKRSRSGSQGRTDSVEKSK-KREHSPSKEK------SRKRSRSKER 506



 Score = 90.5 bits (223), Expect = 2e-17
 Identities = 75/273 (27%), Positives = 127/273 (46%), Gaps = 33/273 (12%)

Query: 1765 RSAASPVVSSMPERA---SESSSEEKDDY---EIFVKVKDTHEKSKKNKNRDKGEKEKKR 1818
            R + SP  S  P R+   S S S  ++ +       +++   E+ +  +   + EKE++R
Sbjct: 258  RRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRR 317

Query: 1819 DSSL-------RSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSR--- 1868
              S+       RSRS+    S  +SR R  + R R R+R  +++  R + R   + R   
Sbjct: 318  SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNE 377

Query: 1869 --RRRRSSRSRSKSRGRRSVSKEKRKRSPKH--------RSKSRERKRKRSSSRDNRKTV 1918
              + R  SR RSK +  R   +EK+ +  K         R   +E+K  RS SR+ +   
Sbjct: 378  REKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRS 437

Query: 1919 RARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPS-RRSRTPS-----RRSRTPSR-RS 1971
            R+RSR   +RSRS +  +  + ++  + +S   S S  + RT S     +R  +PS+ +S
Sbjct: 438  RSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKS 497

Query: 1972 RTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSV 2004
            R  SR      +R  + S+       RRRS+S+
Sbjct: 498  RKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSI 530



 Score = 56.6 bits (135), Expect = 3e-07
 Identities = 40/154 (25%), Positives = 74/154 (48%), Gaps = 10/154 (6%)

Query: 1774 SMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSL--------RSR 1825
            S  E   +   E+KDD       +D+ ++ K +++R +  K + R  S         RS+
Sbjct: 394  SRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSK 453

Query: 1826 SKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGR-R 1884
             K SK       K    SRS ++ R+   +  + +  S S+ + R+R SRS+ +S  R  
Sbjct: 454  EKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKR-SRSKERSHKRDH 512

Query: 1885 SVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTV 1918
            S SK++  +  + RS+S E++ +    ++  +TV
Sbjct: 513  SDSKDQSDKHDRRRSQSIEQESQEKQHKNKDETV 546



 Score = 48.9 bits (115), Expect = 6e-05
 Identities = 50/156 (32%), Positives = 61/156 (39%), Gaps = 11/156 (7%)

Query: 1896 KHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSR 1955
            K R +  ++  K  +   +R   R RSR+P R        RR RSRS  R    S S  R
Sbjct: 234  KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR 293

Query: 1956 RSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPV 2015
                   R R           R     RRSR+  R       RRRSRS  R RS S S  
Sbjct: 294  ELEREKERQRLEREAKEREKER-----RRSRSIDRGLE----RRRSRSRERHRSRSRSRD 344

Query: 2016 RL--RRSRTPLRRRFSRSPIRRKRSRSSERGRSPKR 2049
            R   RR R   R + +    RR R    ERG   ++
Sbjct: 345  RKGDRRDRDREREKENERGRRRDRDYDKERGNEREK 380



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 51/192 (26%), Positives = 73/192 (38%), Gaps = 15/192 (7%)

Query: 1877 RSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSR 1936
            +++ R  +   KE  +   +H  + R R  +RS S   R   R+RSR+  R     +   
Sbjct: 234  KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLS-PRRSPRRSRSRSHHREGHGSSSFD 292

Query: 1937 RRRSRSVGRRR-----SFSISPSRRSRT-----PSRRSRTPSRRSRTPSRRSRTPSRRSR 1986
            R   R   R+R            RRSR+       RRSR+  R       R R   RR R
Sbjct: 293  RELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR 352

Query: 1987 TPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPI---RRKRSRSSER 2043
               R       RRR R   + R       R  RSR   + + SR  +   + K  +   R
Sbjct: 353  DREREKENERGRRRDRDYDKERGNEREKER-ERSRERSKEQRSRGEVEEKKHKEDKDDRR 411

Query: 2044 GRSPKRLTDLDK 2055
             R  KR +  +K
Sbjct: 412  HRDDKRDSKKEK 423



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 1/67 (1%)

Query: 78  RYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESE 137
           ++K + KE S K R  S     TD +   K ++H   K K +K+ + KE+ +KR   +S+
Sbjct: 458 KHKNESKEKSNK-RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSK 516

Query: 138 SKTKSHD 144
            ++  HD
Sbjct: 517 DQSDKHD 523


>gi|42741682 zinc finger protein 265 isoform 2 [Homo sapiens]
          Length = 320

 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 71/158 (44%), Positives = 88/158 (55%), Gaps = 14/158 (8%)

Query: 1781 ESSSEEKDDYEIFVKVK-------DTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSE 1833
            ES  EE+D+ E   K K       D  + SK N +  + E   K+ S+ RSRSK S+SS 
Sbjct: 152  ESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSK-SRSSH 210

Query: 1834 HKSRKRTSE---SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRR-SVSKE 1889
             +S  R+S    SRSR+R RS  S S +S++RS SR R R R S+SRS SR  R S S  
Sbjct: 211  SRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPR 270

Query: 1890 KRKRSPKHRSKSRERK--RKRSSSRDNRKTVRARSRTP 1925
            KR  S    S  R RK  R RSSS  +RK  R RSR+P
Sbjct: 271  KRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSP 308



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 67/181 (37%), Positives = 94/181 (51%), Gaps = 26/181 (14%)

Query: 1796 VKDTHEKSKKNKNRDKGE--------KEKKRDSSLRSRSKRSKSSEHKSRKRTSESRSRA 1847
            +K+  +K  + +  D+ E        +++  D +  S+     S E  S K+ S  RSR+
Sbjct: 145  LKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRS 204

Query: 1848 RKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKR-SPKHRSKSRERKR 1906
            + RSS S   RS +RS S S     SSRSRS+SR R S S + R R S + RS+SR  K 
Sbjct: 205  KSRSSHS---RSSSRSSSPS-----SSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSK- 255

Query: 1907 KRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRT 1966
             RSSSR +R      S +P +RS S + S   R+R   R RS S    ++ RT   RSR+
Sbjct: 256  SRSSSRSHR-----GSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRT---RSRS 307

Query: 1967 P 1967
            P
Sbjct: 308  P 308



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 62/188 (32%), Positives = 89/188 (47%), Gaps = 17/188 (9%)

Query: 1871 RRSSRSRSKSRGRRSVSKEKRKRSPKHRSKSRER---KRKRSSSRD------NRKTVRAR 1921
            R+  + R K+ G  S+ KE   +  +   +  +    K K     D      ++  + A 
Sbjct: 129  RKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDAS 188

Query: 1922 SRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTP 1981
                S + +S+  SR +   S  R  S S SPS  SR+   RSR+ SR S +   RSR+ 
Sbjct: 189  EEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSS-SRS---RSRSRSRSSSSSQSRSRSS 244

Query: 1982 SR-RSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040
            SR RSR+   +SR+ SR  R  S  R+RS+S S     R+R   R R S S  R+KR   
Sbjct: 245  SRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKR--- 301

Query: 2041 SERGRSPK 2048
              R RSP+
Sbjct: 302  RTRSRSPE 309



 Score = 51.6 bits (122), Expect = 9e-06
 Identities = 42/136 (30%), Positives = 60/136 (44%), Gaps = 13/136 (9%)

Query: 1760 DVGRDRSAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRD 1819
            D   D   A     ++     E S+++K +     K + +H +S    +     + + R 
Sbjct: 170  DEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRS 229

Query: 1820 SSLRSRSKRSKS---SEHKSRKRTSESRSRAR---------KRSSKSKSHRSQTRSRSRS 1867
             S  S S +S+S   S  +SR R S+SRS +R         KRS  S S  S  R+R RS
Sbjct: 230  RSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSS-SSPERNRKRS 288

Query: 1868 RRRRRSSRSRSKSRGR 1883
            R R  SS  R K R R
Sbjct: 289  RSRSSSSGDRKKRRTR 304


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 174/803 (21%), Positives = 282/803 (35%), Gaps = 100/803 (12%)

Query: 80  KPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESK 139
           +P L   S  S+  S+  +    + TK++    K  +   K+K    K+      +S  K
Sbjct: 127 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE-----TQSIEK 181

Query: 140 TKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEP 199
           T + D                 P++  L  PT       T + PA+            EP
Sbjct: 182 TSAKD---------------LAPTSKVLAKPTPK--AETTTKGPALTTP--------KEP 216

Query: 200 HILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTT---LV 256
                 +PA+ T +    +T     +S  +    P P+ TK   +    P PTTT     
Sbjct: 217 TPTTPKEPASTTPKEPTPTTI----KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 272

Query: 257 LKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEV 316
               EP  T + E    +  KS  +T  EP+     +P      EP+ T   + + PT  
Sbjct: 273 TTPKEPAPTTTKE-PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT---TPKEPTPT 328

Query: 317 YP-EPSTSTTMDFPESSAIEALRLPEQPVDV-PSEIADSSMTRP------QELPELPKTT 368
            P EP+ +T    P +    A   P++P    P E A ++   P      +  P  PK  
Sbjct: 329 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 388

Query: 369 ALELQESSVASAMELPGPPAT-SMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPEL 427
           A    +S+  +  E P P  T S P     P     + P P+ TP    P     P P  
Sbjct: 389 APTTTKSAPTTTKE-PAPTTTKSAPTTPKEPSPTTTKEPAPT-TPKEPAPTTPKKPAPTT 446

Query: 428 PGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTA 487
           P  PA   P+ P P+ T  P  +   P  PAP+    P +  P  P   ++L        
Sbjct: 447 PKEPAPTTPKEPAPTTTKKP--APTTPKEPAPT---TPKETAPTTP---KKLTPTTPEKL 498

Query: 488 AVELPEQPAVTVAMELT----EQPVTTTELEQPVGMT----TVEHPGHPEVTTATGLLGQ 539
           A   PE+PA T   EL     E+P  TT  E+P   T        P  P  TT      +
Sbjct: 499 APTTPEKPAPTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPK----E 553

Query: 540 PEATMVLELPGQPVATTALE-LPGQPSVTG-------VPELPGLPSATRALELSGQPVAT 591
           P  T     P +P  TT  E  P  P  T         P  P  P+       + +   +
Sbjct: 554 PAPT----TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 609

Query: 592 GALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVAL 651
              + P P    G    + +  A    +        G      +  AP  P +P      
Sbjct: 610 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK--- 666

Query: 652 EISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAP 711
               +   TT++  T T S     P+T    +  T  +  PTT       T    P    
Sbjct: 667 ----ELAPTTTKGPTSTTSDK-PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 721

Query: 712 ESHILASNTMETHILASNTMDSQMLAS----NTMDSQMLASNTMDSQMLASSTMDSQMLA 767
           E     +    T I  S    +  L++      +++         ++  A++  +    A
Sbjct: 722 EVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 781

Query: 768 TSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLA 827
                 + L T+   +      T ++      + +S++ AT+   +Q+ +T++ D+    
Sbjct: 782 KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT---TQVTSTTTQDTTPFK 838

Query: 828 TSSMDSQMLATSTMDSQMLATST 850
            +++ +  LA     ++   T+T
Sbjct: 839 ITTLKTTTLAPKVTTTKKTITTT 861



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 181/870 (20%), Positives = 302/870 (34%), Gaps = 131/870 (15%)

Query: 1149 LPPEEPPTMPPLPPEEPPMTPPL--PPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEE 1206
            L P       P P  E     P    P+EP   P  P E ++ T +   PT + S+P+  
Sbjct: 187  LAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAPT-- 242

Query: 1207 SVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVES 1266
            +  +P P  ++S  + P   P   +     P+     A  T  EP P    S   TP E 
Sbjct: 243  TPKEPAPTTTKSAPTTPKE-PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 301

Query: 1267 AVVAEEHEVVPERPVTCMVSE-TPAMSAEPT-VLASEP-PVMSETAETFDSMRASGHVAS 1323
            A         P++P      E  P    EPT     EP P   E A T     A      
Sbjct: 302  A------PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKK 355

Query: 1324 EVSTSLLVPAVTTP-VLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVT 1382
               T+   PA TTP   A +  + P+   P+  A    +S+  T  E +  T  +S+  T
Sbjct: 356  PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT-KSAPTT 414

Query: 1383 VLEPSVVTV--PEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440
              EPS  T   P P    EP   T   P      P+ P      +  +P+     P+ + 
Sbjct: 415  PKEPSPTTTKEPAPTTPKEPAPTTPKKPA-----PTTPKEPAPTTPKEPA-----PTTTK 464

Query: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500
            + +  T  EPA T  ++T     +    +TP  L  +                +  AP  
Sbjct: 465  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--------------PEKPAPTT 510

Query: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560
              +E+A  + EEP                             +E    T  AA  +   E
Sbjct: 511  -PEELAPTTPEEP------------------------TPTTPEEPAPTTPKAAAPNTPKE 545

Query: 1561 IGEEKILPTS--ETKQRTVLDTYPGVSEADAGETLSSTGPFAL-EPDATGTSKGIEFTTA 1617
                   PT+  E    T  +  P   +  A  T   T P  L EP  T   K      A
Sbjct: 546  PA-----PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 600

Query: 1618 STLSLVNKYDVDLSLTTQD---TEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNL 1674
             T             TT++   T  D    T+P G +    + P P        P     
Sbjct: 601  PT-------------TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT------TPKEPAP 641

Query: 1675 VSKDTEEPLPVKESDQTLAALLSPKE----------SSGGEKEVPPPPKETLPDSGFSAN 1724
             +     P  +KE   T     +PKE          S+  +K  P  PKET P +     
Sbjct: 642  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 701

Query: 1725 IEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMP-ERASESS 1783
                 +     P  P       S     + P   + + +    ++P +S+ P  +A E+S
Sbjct: 702  PTTPKKPAPTTPETPPPTTSEVSTPTTTKEP---TTIHKSPDESTPELSAEPTPKALENS 758

Query: 1784 SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSE- 1842
             +E       V    T   +K        +K  +RD      +  +     K    T+E 
Sbjct: 759  PKEPG-----VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEK 813

Query: 1843 -SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS 1901
             + S+    +++  S  +Q  +  +    + ++ +   +  +++++  +    P+  +K 
Sbjct: 814  TTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP 873

Query: 1902 RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961
            ++R         N K    + + P++  +   P+  ++ +++ R R    +P+ R  T +
Sbjct: 874  KDR-------ATNSKATTPKPQKPTKAPKK--PTSTKKPKTMPRVRKPKTTPTPRKMTST 924

Query: 1962 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRR 1991
                 P+  SR      +T +R ++TP+ +
Sbjct: 925  MPELNPT--SRIAEAMLQTTTRPNQTPNSK 952



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 84/344 (24%), Positives = 124/344 (36%), Gaps = 19/344 (5%)

Query: 1141 TEAYMVPPLPPEEPPTMPPL---PPEEPPMTPPLPPEEPPEGPALPTEQSA-LTAENTWP 1196
            T   +  P P  E  T  P    P E  P TP  P    P+ P   T +SA  T +   P
Sbjct: 190  TSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 249

Query: 1197 TEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVP-EP-PPE 1254
            T   S+P+    +  EP  + ++   P+        +  +P+   +++A T P EP P  
Sbjct: 250  TTTKSAPT----TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 305

Query: 1255 PESSITLTPVESAVVA--EEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMS---ETA 1309
            P+     TP E A     E     P+ P        P    EP   A + P  +   E A
Sbjct: 306  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 365

Query: 1310 ETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLE 1369
             T     A         T+   PA TT   A +  + PA    +S+     E S  T  E
Sbjct: 366  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 425

Query: 1370 SSTVTVLESSTVTVLEPSVVT--VPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVL 1427
             +  T  E +  T  +P+  T   P P    EP   T   P  +  +   P      +  
Sbjct: 426  PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 485

Query: 1428 QPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
             P  +   P+   + +  T  +PA T  E+      E    +TP
Sbjct: 486  TPKKLT--PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 527



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 126/524 (24%), Positives = 187/524 (35%), Gaps = 71/524 (13%)

Query: 188 EPPVVSMEVS--EPHILETLKPATKTAELSVVSTS---VISEQSEQSVAVMP------EP 236
           +PPVV    S  +    +   P T T + + VSTS     ++      ++ P      E 
Sbjct: 81  KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 140

Query: 237 SMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPV 296
           S+T   ++       TTT    S++     +   + +S+ K+        SK++    P 
Sbjct: 141 SLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPK 200

Query: 297 AKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMT 356
           A+       L    E PT   P+   STT   P  + I++   P  P +       S+ T
Sbjct: 201 AETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSA--PTTPKEPAPTTTKSAPT 257

Query: 357 RPQE-LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPE 415
            P+E  P   K  A    +    +  + P P  T     +  P TP    P     P P 
Sbjct: 258 TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT-----KSAPTTPKEPAPTTPKKPAPT 312

Query: 416 LPGPLSTPVPELPGPPATAVPELPGPSV-TPVPQLSQELPGLPAPSMGLEPPQEVPEPPV 474
            P     P P  P  P    P+ P P+   P P   +E    PAP+   +P    P+ P 
Sbjct: 313 TP---KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE----PAPTAPKKPAPTTPKEP- 364

Query: 475 MAQELPGLPLVTAAVE----LPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEV 530
            A   P  P  T   E     P++PA T     T+   TTT  ++P   TT   P  P+ 
Sbjct: 365 -APTTPKEPAPTTTKEPSPTTPKEPAPTT----TKSAPTTT--KEPAPTTTKSAPTTPK- 416

Query: 531 TTATGLLGQPEATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVA 590
                   +P  T   E    P  TT    P +P+    P  P  P+ T   E    P  
Sbjct: 417 --------EPSPTTTKE----PAPTT----PKEPA----PTTPKKPAPTTPKE----PAP 452

Query: 591 TGALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVA 650
           T   E P P         + +  A    +         +     +  AP  P +P  T  
Sbjct: 453 TTPKE-PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 511

Query: 651 LEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTT 694
            E++     TT E  T T  +    P+T    + NT  +  PTT
Sbjct: 512 EELA----PTTPEEPTPTTPEE-PAPTTPKAAAPNTPKEPAPTT 550



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 83/342 (24%), Positives = 118/342 (34%), Gaps = 26/342 (7%)

Query: 1139 TYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPT- 1197
            T T     P  P E  PT     P  P    P   +EP   P  P E +  T +   PT 
Sbjct: 233  TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP--APTTPKEPAPTTTKEPAPTT 290

Query: 1198 --EVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYS-VSASDPSVLVSEAAVTVP-EP-P 1252
                P++P E + + P+ P   +        P + +  +  +P+    E A T P EP P
Sbjct: 291  TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 350

Query: 1253 PEPESSITLTPVESA----------VVAEEHEVVPERPVTCMVSETPAMSAE--PTVLAS 1300
              P+     TP E A             E     P+ P        P  + E  PT   S
Sbjct: 351  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 410

Query: 1301 EPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTP-VLAESILEPPAMAAPESSAMAV 1359
             P    E + T     A         T+   PA TTP   A +  + PA    +  A   
Sbjct: 411  APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT 470

Query: 1360 LESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYV---TIPVPVVSALEPS 1416
             +  A T  + +  T  +  T T  E    T PE P    P+ +   T   P  +  E  
Sbjct: 471  PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP 530

Query: 1417 VPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQT 1458
             P    A +   P      P+   + +  T  EPA T  ++T
Sbjct: 531  APTTPKAAAPNTPK--EPAPTTPKEPAPTTPKEPAPTTPKET 570



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 75/343 (21%), Positives = 113/343 (32%), Gaps = 15/343 (4%)

Query: 1141 TEAYMVPPLPPEEPPTMPP-----LPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTW 1195
            T     P  P E  PT P       P E  P TP  P    P+ PA  T++ A T     
Sbjct: 289  TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP 348

Query: 1196 PTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEP 1255
                P  P+  +  +P P   +      +  P+  +     P+   S A  T  EP P  
Sbjct: 349  APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS-APTTTKEPAPTT 407

Query: 1256 ESSITLTPVESA--VVAEEHEVVPERPV-TCMVSETPAMSAEPTVLASEPPVMSETAETF 1312
              S   TP E +     E     P+ P  T      P    EP     + P  + T +  
Sbjct: 408  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 467

Query: 1313 DSMRASGHVASEVSTSLLVPAVTTPV----LAESILEPPAMAAPESSAMAVLESSAVTVL 1368
             +        +   T+   P   TP     LA +  E PA   PE  A    E    T  
Sbjct: 468  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 527

Query: 1369 ESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQ 1428
            E    T  +++     +    T P+ P    P       P  +A  P+ P      ++ +
Sbjct: 528  EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA--PTTPKGTAPTTLKE 585

Query: 1429 PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
            P+    +     + +  T  EP  T  ++      +    +TP
Sbjct: 586  PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP 628



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 95/378 (25%), Positives = 146/378 (38%), Gaps = 42/378 (11%)

Query: 1128 AADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLP--PEEPPMTPP------LPPEEPPEG 1179
            +A + T     T T++    P  P    T  P P  P+EP  T P       P E  P  
Sbjct: 395  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 454

Query: 1180 PALPTEQSALTAENTWPTE-VPSSPSEESVSQPE--PPVSQSEIS----EPSAVPTDYSV 1232
            P  P   +      T P E  P++P E + + P+   P +  +++    E  A  T   +
Sbjct: 455  PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 514

Query: 1233 SASDPSVLVSEAAVTVPE--PPPEPESSITLTPVESAVVA--EEHEVVPERPVTCMVSET 1288
            + + P     E   T PE   P  P+++   TP E A     E     P+ P       T
Sbjct: 515  APTTP----EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP----APTT 566

Query: 1289 PAMSAEPTVLASEPPVMSETAETFDSMRASGHVA-----SEVSTSLLVPAVTTPV-LAES 1342
            P  +A  T   + P  + E A T     A   +A        ST+   PA TTP   A +
Sbjct: 567  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 626

Query: 1343 ILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDY 1402
              + PA   P+  A    + +A T L+    T  +      L P+    P      +P  
Sbjct: 627  TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 686

Query: 1403 VTIPVPVVSALEPSVPVLEPAVSVLQ---PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQ 1459
             T   P  +A  P+ P  EPA +  +   P+   + P  + + ST T ++   T+ +   
Sbjct: 687  TT---PKETA--PTTP-KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 740

Query: 1460 VIPTEVAIESTPMILESS 1477
                E++ E TP  LE+S
Sbjct: 741  ESTPELSAEPTPKALENS 758



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 86/333 (25%), Positives = 124/333 (37%), Gaps = 64/333 (19%)

Query: 1148 PLPPEEP-PTMP----PLPPEEP-PMTP----PLPPEEPPEGPALPTEQSALTAENTWPT 1197
            P  PEEP PT P    P  P+EP P TP    P  P+EP   P  P E +  T + T PT
Sbjct: 524  PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP--APTTPKETAPTTPKGTAPT 581

Query: 1198 EVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP-PPEPE 1256
             +     E + + P+ P  +      +  PT  +     P+     A  T  EP P  P+
Sbjct: 582  TL----KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 637

Query: 1257 SSITLTPVESA--VVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDS 1314
                 TP  +A   + E     P++P    ++  P  +  PT   S+ P  +   ET   
Sbjct: 638  EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA--PTTTKGPTSTTSDKPAPTTPKET--- 692

Query: 1315 MRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVT 1374
                              A TTP       + PA   P+  A    E+   T  E ST T
Sbjct: 693  ------------------APTTP-------KEPAPTTPKKPAPTTPETPPPTTSEVSTPT 727

Query: 1375 VLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVV---SALEPSVPVLE-PAVSVLQPS 1430
                   T  EP+  T+ + P  + P+    P P     S  EP VP  + PA +  +P 
Sbjct: 728  -------TTKEPT--TIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT--KPE 776

Query: 1431 MIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPT 1463
            M  +    + +    T  E      + T+   T
Sbjct: 777  MTTTAKDKTTERDLRTTPETTTAAPKMTKETAT 809



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 75/322 (23%), Positives = 109/322 (33%), Gaps = 25/322 (7%)

Query: 1156 TMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPV 1215
            T  P+ P   P  PP           +  E +  T E T   +  S+  +E  +  +   
Sbjct: 120  TAKPINPR--PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 177

Query: 1216 SQSEISEPSAVPTDYSVSASDPSVLVSEA--AVTVPEPPPEPESSITLTPVESAVVAEEH 1273
            S  + S     PT   ++   P    +    A+T P+ P         TP E A      
Sbjct: 178  SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPT------TPKEPA------ 225

Query: 1274 EVVPERPVTCMVSETPAMSAEP--TVLASEPPVMSETAETFDSMRASGHVASEVSTSLLV 1331
               P+ P    +   P    EP  T   S P    E A T     A         T+   
Sbjct: 226  STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 285

Query: 1332 PAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTV 1391
            PA TT   A +  + PA   P+  A    +  A T  +  T T  +    T  EP+  T 
Sbjct: 286  PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTP 345

Query: 1392 PEPPVVA--EPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQEST-VTVS 1448
             EP   A  +P   T   P  +  +   P      S   P     EP+ +  +S   T  
Sbjct: 346  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTP----KEPAPTTTKSAPTTTK 401

Query: 1449 EPAVTVSEQTQVIPTEVAIEST 1470
            EPA T ++     P E +  +T
Sbjct: 402  EPAPTTTKSAPTTPKEPSPTTT 423



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 63/267 (23%), Positives = 97/267 (36%), Gaps = 30/267 (11%)

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSE-- 1205
            P P     T P  P E  P TP  P    PE P   T + +       PT +  SP E  
Sbjct: 684  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 743

Query: 1206 -ESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPV 1264
             E  ++P P   ++   EP  VPT  + +A+ P +  +    T        E  +  TP 
Sbjct: 744  PELSAEPTPKALENSPKEP-GVPTTKTPAATKPEMTTTAKDKTT-------ERDLRTTP- 794

Query: 1265 ESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASE 1324
            E+   A +        +T   + T   + E  + A+   V S T +     +      + 
Sbjct: 795  ETTTAAPK--------MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK-----ITT 841

Query: 1325 VSTSLLVPAVTTPVLAESILEPPAMAAPESSAM---AVLESSAVTVLESSTVTVLESSTV 1381
            + T+ L P VTT    ++I     M  PE +A        S A T          +  T 
Sbjct: 842  LKTTTLAPKVTT--TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 899

Query: 1382 TVLEPSVVTVPEPPVVAEPDYVTIPVP 1408
            T    ++  V +P     P  +T  +P
Sbjct: 900  TKKPKTMPRVRKPKTTPTPRKMTSTMP 926



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 13/133 (9%)

Query: 1173 PEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSV 1232
            PEE  +     T   A T +   PT+ P  P     +  + P +   + +P   PT   +
Sbjct: 867  PEETAKPKDRATNSKATTPKPQKPTKAPKKP-----TSTKKPKTMPRVRKPKTTPTPRKM 921

Query: 1233 SAS----DPSVLVSEAAV-TVPEPPPEPESSITLTPVESAVVAEEHEVVPE---RPVTCM 1284
            +++    +P+  ++EA + T   P   P S +     +S          P    RP   M
Sbjct: 922  TSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFM 981

Query: 1285 VSETPAMSAEPTV 1297
               TP M   P V
Sbjct: 982  PEVTPDMDYLPRV 994


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 174/803 (21%), Positives = 282/803 (35%), Gaps = 100/803 (12%)

Query: 80  KPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESK 139
           +P L   S  S+  S+  +    + TK++    K  +   K+K    K+      +S  K
Sbjct: 168 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE-----TQSIEK 222

Query: 140 TKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEP 199
           T + D                 P++  L  PT       T + PA+            EP
Sbjct: 223 TSAKD---------------LAPTSKVLAKPTPK--AETTTKGPALTTP--------KEP 257

Query: 200 HILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTT---LV 256
                 +PA+ T +    +T     +S  +    P P+ TK   +    P PTTT     
Sbjct: 258 TPTTPKEPASTTPKEPTPTTI----KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 313

Query: 257 LKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEV 316
               EP  T + E    +  KS  +T  EP+     +P      EP+ T   + + PT  
Sbjct: 314 TTPKEPAPTTTKE-PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT---TPKEPTPT 369

Query: 317 YP-EPSTSTTMDFPESSAIEALRLPEQPVDV-PSEIADSSMTRP------QELPELPKTT 368
            P EP+ +T    P +    A   P++P    P E A ++   P      +  P  PK  
Sbjct: 370 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 429

Query: 369 ALELQESSVASAMELPGPPAT-SMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPEL 427
           A    +S+  +  E P P  T S P     P     + P P+ TP    P     P P  
Sbjct: 430 APTTTKSAPTTTKE-PAPTTTKSAPTTPKEPSPTTTKEPAPT-TPKEPAPTTPKKPAPTT 487

Query: 428 PGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTA 487
           P  PA   P+ P P+ T  P  +   P  PAP+    P +  P  P   ++L        
Sbjct: 488 PKEPAPTTPKEPAPTTTKKP--APTTPKEPAPT---TPKETAPTTP---KKLTPTTPEKL 539

Query: 488 AVELPEQPAVTVAMELT----EQPVTTTELEQPVGMT----TVEHPGHPEVTTATGLLGQ 539
           A   PE+PA T   EL     E+P  TT  E+P   T        P  P  TT      +
Sbjct: 540 APTTPEKPAPTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPK----E 594

Query: 540 PEATMVLELPGQPVATTALE-LPGQPSVTG-------VPELPGLPSATRALELSGQPVAT 591
           P  T     P +P  TT  E  P  P  T         P  P  P+       + +   +
Sbjct: 595 PAPT----TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 650

Query: 592 GALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVAL 651
              + P P    G    + +  A    +        G      +  AP  P +P      
Sbjct: 651 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK--- 707

Query: 652 EISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAP 711
               +   TT++  T T S     P+T    +  T  +  PTT       T    P    
Sbjct: 708 ----ELAPTTTKGPTSTTSDK-PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 762

Query: 712 ESHILASNTMETHILASNTMDSQMLAS----NTMDSQMLASNTMDSQMLASSTMDSQMLA 767
           E     +    T I  S    +  L++      +++         ++  A++  +    A
Sbjct: 763 EVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 822

Query: 768 TSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLA 827
                 + L T+   +      T ++      + +S++ AT+   +Q+ +T++ D+    
Sbjct: 823 KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT---TQVTSTTTQDTTPFK 879

Query: 828 TSSMDSQMLATSTMDSQMLATST 850
            +++ +  LA     ++   T+T
Sbjct: 880 ITTLKTTTLAPKVTTTKKTITTT 902



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 181/870 (20%), Positives = 302/870 (34%), Gaps = 131/870 (15%)

Query: 1149 LPPEEPPTMPPLPPEEPPMTPPL--PPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEE 1206
            L P       P P  E     P    P+EP   P  P E ++ T +   PT + S+P+  
Sbjct: 228  LAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAPT-- 283

Query: 1207 SVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVES 1266
            +  +P P  ++S  + P   P   +     P+     A  T  EP P    S   TP E 
Sbjct: 284  TPKEPAPTTTKSAPTTPKE-PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 342

Query: 1267 AVVAEEHEVVPERPVTCMVSE-TPAMSAEPT-VLASEP-PVMSETAETFDSMRASGHVAS 1323
            A         P++P      E  P    EPT     EP P   E A T     A      
Sbjct: 343  A------PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKK 396

Query: 1324 EVSTSLLVPAVTTP-VLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVT 1382
               T+   PA TTP   A +  + P+   P+  A    +S+  T  E +  T  +S+  T
Sbjct: 397  PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT-KSAPTT 455

Query: 1383 VLEPSVVTV--PEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440
              EPS  T   P P    EP   T   P      P+ P      +  +P+     P+ + 
Sbjct: 456  PKEPSPTTTKEPAPTTPKEPAPTTPKKPA-----PTTPKEPAPTTPKEPA-----PTTTK 505

Query: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500
            + +  T  EPA T  ++T     +    +TP  L  +                +  AP  
Sbjct: 506  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--------------PEKPAPTT 551

Query: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560
              +E+A  + EEP                             +E    T  AA  +   E
Sbjct: 552  -PEELAPTTPEEP------------------------TPTTPEEPAPTTPKAAAPNTPKE 586

Query: 1561 IGEEKILPTS--ETKQRTVLDTYPGVSEADAGETLSSTGPFAL-EPDATGTSKGIEFTTA 1617
                   PT+  E    T  +  P   +  A  T   T P  L EP  T   K      A
Sbjct: 587  PA-----PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 641

Query: 1618 STLSLVNKYDVDLSLTTQD---TEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNL 1674
             T             TT++   T  D    T+P G +    + P P        P     
Sbjct: 642  PT-------------TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPT------TPKEPAP 682

Query: 1675 VSKDTEEPLPVKESDQTLAALLSPKE----------SSGGEKEVPPPPKETLPDSGFSAN 1724
             +     P  +KE   T     +PKE          S+  +K  P  PKET P +     
Sbjct: 683  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 742

Query: 1725 IEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMP-ERASESS 1783
                 +     P  P       S     + P   + + +    ++P +S+ P  +A E+S
Sbjct: 743  PTTPKKPAPTTPETPPPTTSEVSTPTTTKEP---TTIHKSPDESTPELSAEPTPKALENS 799

Query: 1784 SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSE- 1842
             +E       V    T   +K        +K  +RD      +  +     K    T+E 
Sbjct: 800  PKEPG-----VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEK 854

Query: 1843 -SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS 1901
             + S+    +++  S  +Q  +  +    + ++ +   +  +++++  +    P+  +K 
Sbjct: 855  TTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP 914

Query: 1902 RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961
            ++R         N K    + + P++  +   P+  ++ +++ R R    +P+ R  T +
Sbjct: 915  KDR-------ATNSKATTPKPQKPTKAPKK--PTSTKKPKTMPRVRKPKTTPTPRKMTST 965

Query: 1962 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRR 1991
                 P+  SR      +T +R ++TP+ +
Sbjct: 966  MPELNPT--SRIAEAMLQTTTRPNQTPNSK 993



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 84/344 (24%), Positives = 124/344 (36%), Gaps = 19/344 (5%)

Query: 1141 TEAYMVPPLPPEEPPTMPPL---PPEEPPMTPPLPPEEPPEGPALPTEQSA-LTAENTWP 1196
            T   +  P P  E  T  P    P E  P TP  P    P+ P   T +SA  T +   P
Sbjct: 231  TSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAP 290

Query: 1197 TEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVP-EP-PPE 1254
            T   S+P+    +  EP  + ++   P+        +  +P+   +++A T P EP P  
Sbjct: 291  TTTKSAPT----TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTT 346

Query: 1255 PESSITLTPVESAVVA--EEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMS---ETA 1309
            P+     TP E A     E     P+ P        P    EP   A + P  +   E A
Sbjct: 347  PKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPA 406

Query: 1310 ETFDSMRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLE 1369
             T     A         T+   PA TT   A +  + PA    +S+     E S  T  E
Sbjct: 407  PTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKE 466

Query: 1370 SSTVTVLESSTVTVLEPSVVT--VPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVL 1427
             +  T  E +  T  +P+  T   P P    EP   T   P  +  +   P      +  
Sbjct: 467  PAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPT 526

Query: 1428 QPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
             P  +   P+   + +  T  +PA T  E+      E    +TP
Sbjct: 527  TPKKLT--PTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 568



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 126/524 (24%), Positives = 187/524 (35%), Gaps = 71/524 (13%)

Query: 188 EPPVVSMEVS--EPHILETLKPATKTAELSVVSTS---VISEQSEQSVAVMP------EP 236
           +PPVV    S  +    +   P T T + + VSTS     ++      ++ P      E 
Sbjct: 122 KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKET 181

Query: 237 SMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPV 296
           S+T   ++       TTT    S++     +   + +S+ K+        SK++    P 
Sbjct: 182 SLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPK 241

Query: 297 AKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPESSAIEALRLPEQPVDVPSEIADSSMT 356
           A+       L    E PT   P+   STT   P  + I++   P  P +       S+ T
Sbjct: 242 AETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTIKSA--PTTPKEPAPTTTKSAPT 298

Query: 357 RPQE-LPELPKTTALELQESSVASAMELPGPPATSMPELQGPPVTPVLELPGPSATPVPE 415
            P+E  P   K  A    +    +  + P P  T     +  P TP    P     P P 
Sbjct: 299 TPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT-----KSAPTTPKEPAPTTPKKPAPT 353

Query: 416 LPGPLSTPVPELPGPPATAVPELPGPSV-TPVPQLSQELPGLPAPSMGLEPPQEVPEPPV 474
            P     P P  P  P    P+ P P+   P P   +E    PAP+   +P    P+ P 
Sbjct: 354 TP---KEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE----PAPTAPKKPAPTTPKEP- 405

Query: 475 MAQELPGLPLVTAAVE----LPEQPAVTVAMELTEQPVTTTELEQPVGMTTVEHPGHPEV 530
            A   P  P  T   E     P++PA T     T+   TTT  ++P   TT   P  P+ 
Sbjct: 406 -APTTPKEPAPTTTKEPSPTTPKEPAPTT----TKSAPTTT--KEPAPTTTKSAPTTPK- 457

Query: 531 TTATGLLGQPEATMVLELPGQPVATTALELPGQPSVTGVPELPGLPSATRALELSGQPVA 590
                   +P  T   E    P  TT    P +P+    P  P  P+ T   E    P  
Sbjct: 458 --------EPSPTTTKE----PAPTT----PKEPA----PTTPKKPAPTTPKE----PAP 493

Query: 591 TGALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVA 650
           T   E P P         + +  A    +         +     +  AP  P +P  T  
Sbjct: 494 TTPKE-PAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTP 552

Query: 651 LEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTT 694
            E++     TT E  T T  +    P+T    + NT  +  PTT
Sbjct: 553 EELA----PTTPEEPTPTTPEE-PAPTTPKAAAPNTPKEPAPTT 591



 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 83/342 (24%), Positives = 118/342 (34%), Gaps = 26/342 (7%)

Query: 1139 TYTEAYMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPT- 1197
            T T     P  P E  PT     P  P    P   +EP   P  P E +  T +   PT 
Sbjct: 274  TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEP--APTTPKEPAPTTTKEPAPTT 331

Query: 1198 --EVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYS-VSASDPSVLVSEAAVTVP-EP-P 1252
                P++P E + + P+ P   +        P + +  +  +P+    E A T P EP P
Sbjct: 332  TKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAP 391

Query: 1253 PEPESSITLTPVESA----------VVAEEHEVVPERPVTCMVSETPAMSAE--PTVLAS 1300
              P+     TP E A             E     P+ P        P  + E  PT   S
Sbjct: 392  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 451

Query: 1301 EPPVMSETAETFDSMRASGHVASEVSTSLLVPAVTTP-VLAESILEPPAMAAPESSAMAV 1359
             P    E + T     A         T+   PA TTP   A +  + PA    +  A   
Sbjct: 452  APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT 511

Query: 1360 LESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYV---TIPVPVVSALEPS 1416
             +  A T  + +  T  +  T T  E    T PE P    P+ +   T   P  +  E  
Sbjct: 512  PKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEP 571

Query: 1417 VPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQT 1458
             P    A +   P      P+   + +  T  EPA T  ++T
Sbjct: 572  APTTPKAAAPNTPK--EPAPTTPKEPAPTTPKEPAPTTPKET 611



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 75/343 (21%), Positives = 113/343 (32%), Gaps = 15/343 (4%)

Query: 1141 TEAYMVPPLPPEEPPTMPP-----LPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTW 1195
            T     P  P E  PT P       P E  P TP  P    P+ PA  T++ A T     
Sbjct: 330  TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP 389

Query: 1196 PTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEP 1255
                P  P+  +  +P P   +      +  P+  +     P+   S A  T  EP P  
Sbjct: 390  APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS-APTTTKEPAPTT 448

Query: 1256 ESSITLTPVESA--VVAEEHEVVPERPV-TCMVSETPAMSAEPTVLASEPPVMSETAETF 1312
              S   TP E +     E     P+ P  T      P    EP     + P  + T +  
Sbjct: 449  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 508

Query: 1313 DSMRASGHVASEVSTSLLVPAVTTPV----LAESILEPPAMAAPESSAMAVLESSAVTVL 1368
             +        +   T+   P   TP     LA +  E PA   PE  A    E    T  
Sbjct: 509  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 568

Query: 1369 ESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQ 1428
            E    T  +++     +    T P+ P    P       P  +A  P+ P      ++ +
Sbjct: 569  EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA--PTTPKGTAPTTLKE 626

Query: 1429 PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
            P+    +     + +  T  EP  T  ++      +    +TP
Sbjct: 627  PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP 669



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 95/378 (25%), Positives = 146/378 (38%), Gaps = 42/378 (11%)

Query: 1128 AADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLP--PEEPPMTPP------LPPEEPPEG 1179
            +A + T     T T++    P  P    T  P P  P+EP  T P       P E  P  
Sbjct: 436  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 495

Query: 1180 PALPTEQSALTAENTWPTE-VPSSPSEESVSQPE--PPVSQSEIS----EPSAVPTDYSV 1232
            P  P   +      T P E  P++P E + + P+   P +  +++    E  A  T   +
Sbjct: 496  PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 555

Query: 1233 SASDPSVLVSEAAVTVPE--PPPEPESSITLTPVESAVVA--EEHEVVPERPVTCMVSET 1288
            + + P     E   T PE   P  P+++   TP E A     E     P+ P       T
Sbjct: 556  APTTP----EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP----APTT 607

Query: 1289 PAMSAEPTVLASEPPVMSETAETFDSMRASGHVA-----SEVSTSLLVPAVTTPV-LAES 1342
            P  +A  T   + P  + E A T     A   +A        ST+   PA TTP   A +
Sbjct: 608  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 667

Query: 1343 ILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDY 1402
              + PA   P+  A    + +A T L+    T  +      L P+    P      +P  
Sbjct: 668  TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 727

Query: 1403 VTIPVPVVSALEPSVPVLEPAVSVLQ---PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQ 1459
             T   P  +A  P+ P  EPA +  +   P+   + P  + + ST T ++   T+ +   
Sbjct: 728  TT---PKETA--PTTP-KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 781

Query: 1460 VIPTEVAIESTPMILESS 1477
                E++ E TP  LE+S
Sbjct: 782  ESTPELSAEPTPKALENS 799



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 86/333 (25%), Positives = 124/333 (37%), Gaps = 64/333 (19%)

Query: 1148 PLPPEEP-PTMP----PLPPEEP-PMTP----PLPPEEPPEGPALPTEQSALTAENTWPT 1197
            P  PEEP PT P    P  P+EP P TP    P  P+EP   P  P E +  T + T PT
Sbjct: 565  PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP--APTTPKETAPTTPKGTAPT 622

Query: 1198 EVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP-PPEPE 1256
             +     E + + P+ P  +      +  PT  +     P+     A  T  EP P  P+
Sbjct: 623  TL----KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 678

Query: 1257 SSITLTPVESA--VVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDS 1314
                 TP  +A   + E     P++P    ++  P  +  PT   S+ P  +   ET   
Sbjct: 679  EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA--PTTTKGPTSTTSDKPAPTTPKET--- 733

Query: 1315 MRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVT 1374
                              A TTP       + PA   P+  A    E+   T  E ST T
Sbjct: 734  ------------------APTTP-------KEPAPTTPKKPAPTTPETPPPTTSEVSTPT 768

Query: 1375 VLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVV---SALEPSVPVLE-PAVSVLQPS 1430
                   T  EP+  T+ + P  + P+    P P     S  EP VP  + PA +  +P 
Sbjct: 769  -------TTKEPT--TIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT--KPE 817

Query: 1431 MIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPT 1463
            M  +    + +    T  E      + T+   T
Sbjct: 818  MTTTAKDKTTERDLRTTPETTTAAPKMTKETAT 850



 Score = 61.6 bits (148), Expect = 9e-09
 Identities = 75/322 (23%), Positives = 109/322 (33%), Gaps = 25/322 (7%)

Query: 1156 TMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPV 1215
            T  P+ P   P  PP           +  E +  T E T   +  S+  +E  +  +   
Sbjct: 161  TAKPINPR--PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQ 218

Query: 1216 SQSEISEPSAVPTDYSVSASDPSVLVSEA--AVTVPEPPPEPESSITLTPVESAVVAEEH 1273
            S  + S     PT   ++   P    +    A+T P+ P         TP E A      
Sbjct: 219  SIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPT------TPKEPA------ 266

Query: 1274 EVVPERPVTCMVSETPAMSAEP--TVLASEPPVMSETAETFDSMRASGHVASEVSTSLLV 1331
               P+ P    +   P    EP  T   S P    E A T     A         T+   
Sbjct: 267  STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE 326

Query: 1332 PAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTV 1391
            PA TT   A +  + PA   P+  A    +  A T  +  T T  +    T  EP+  T 
Sbjct: 327  PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTP 386

Query: 1392 PEPPVVA--EPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQEST-VTVS 1448
             EP   A  +P   T   P  +  +   P      S   P     EP+ +  +S   T  
Sbjct: 387  KEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTP----KEPAPTTTKSAPTTTK 442

Query: 1449 EPAVTVSEQTQVIPTEVAIEST 1470
            EPA T ++     P E +  +T
Sbjct: 443  EPAPTTTKSAPTTPKEPSPTTT 464



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 63/267 (23%), Positives = 97/267 (36%), Gaps = 30/267 (11%)

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSE-- 1205
            P P     T P  P E  P TP  P    PE P   T + +       PT +  SP E  
Sbjct: 725  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 784

Query: 1206 -ESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPV 1264
             E  ++P P   ++   EP  VPT  + +A+ P +  +    T        E  +  TP 
Sbjct: 785  PELSAEPTPKALENSPKEP-GVPTTKTPAATKPEMTTTAKDKTT-------ERDLRTTP- 835

Query: 1265 ESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASE 1324
            E+   A +        +T   + T   + E  + A+   V S T +     +      + 
Sbjct: 836  ETTTAAPK--------MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK-----ITT 882

Query: 1325 VSTSLLVPAVTTPVLAESILEPPAMAAPESSAM---AVLESSAVTVLESSTVTVLESSTV 1381
            + T+ L P VTT    ++I     M  PE +A        S A T          +  T 
Sbjct: 883  LKTTTLAPKVTT--TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 940

Query: 1382 TVLEPSVVTVPEPPVVAEPDYVTIPVP 1408
            T    ++  V +P     P  +T  +P
Sbjct: 941  TKKPKTMPRVRKPKTTPTPRKMTSTMP 967



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 13/133 (9%)

Query: 1173 PEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSV 1232
            PEE  +     T   A T +   PT+ P  P     +  + P +   + +P   PT   +
Sbjct: 908  PEETAKPKDRATNSKATTPKPQKPTKAPKKP-----TSTKKPKTMPRVRKPKTTPTPRKM 962

Query: 1233 SAS----DPSVLVSEAAV-TVPEPPPEPESSITLTPVESAVVAEEHEVVPE---RPVTCM 1284
            +++    +P+  ++EA + T   P   P S +     +S          P    RP   M
Sbjct: 963  TSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFM 1022

Query: 1285 VSETPAMSAEPTV 1297
               TP M   P V
Sbjct: 1023 PEVTPDMDYLPRV 1035


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 174/803 (21%), Positives = 282/803 (35%), Gaps = 100/803 (12%)

Query: 80  KPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESK 139
           +P L   S  S+  S+  +    + TK++    K  +   K+K    K+      +S  K
Sbjct: 220 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE-----TQSIEK 274

Query: 140 TKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEP 199
           T + D                 P++  L  PT       T + PA+            EP
Sbjct: 275 TSAKD---------------LAPTSKVLAKPTPK--AETTTKGPALTTP--------KEP 309

Query: 200 HILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTT---LV 256
                 +PA+ T +    +T     +S  +    P P+ TK   +    P PTTT     
Sbjct: 310 TPTTPKEPASTTPKEPTPTTI----KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 365

Query: 257 LKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEV 316
               EP  T + E    +  KS  +T  EP+     +P      EP+ T   + + PT  
Sbjct: 366 TTPKEPAPTTTKE-PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT---TPKEPTPT 421

Query: 317 YP-EPSTSTTMDFPESSAIEALRLPEQPVDV-PSEIADSSMTRP------QELPELPKTT 368
            P EP+ +T    P +    A   P++P    P E A ++   P      +  P  PK  
Sbjct: 422 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 481

Query: 369 ALELQESSVASAMELPGPPAT-SMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPEL 427
           A    +S+  +  E P P  T S P     P     + P P+ TP    P     P P  
Sbjct: 482 APTTTKSAPTTTKE-PAPTTTKSAPTTPKEPSPTTTKEPAPT-TPKEPAPTTPKKPAPTT 539

Query: 428 PGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTA 487
           P  PA   P+ P P+ T  P  +   P  PAP+    P +  P  P   ++L        
Sbjct: 540 PKEPAPTTPKEPAPTTTKKP--APTTPKEPAPT---TPKETAPTTP---KKLTPTTPEKL 591

Query: 488 AVELPEQPAVTVAMELT----EQPVTTTELEQPVGMT----TVEHPGHPEVTTATGLLGQ 539
           A   PE+PA T   EL     E+P  TT  E+P   T        P  P  TT      +
Sbjct: 592 APTTPEKPAPTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPK----E 646

Query: 540 PEATMVLELPGQPVATTALE-LPGQPSVTG-------VPELPGLPSATRALELSGQPVAT 591
           P  T     P +P  TT  E  P  P  T         P  P  P+       + +   +
Sbjct: 647 PAPT----TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 702

Query: 592 GALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVAL 651
              + P P    G    + +  A    +        G      +  AP  P +P      
Sbjct: 703 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK--- 759

Query: 652 EISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAP 711
               +   TT++  T T S     P+T    +  T  +  PTT       T    P    
Sbjct: 760 ----ELAPTTTKGPTSTTSDK-PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 814

Query: 712 ESHILASNTMETHILASNTMDSQMLAS----NTMDSQMLASNTMDSQMLASSTMDSQMLA 767
           E     +    T I  S    +  L++      +++         ++  A++  +    A
Sbjct: 815 EVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 874

Query: 768 TSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLA 827
                 + L T+   +      T ++      + +S++ AT+   +Q+ +T++ D+    
Sbjct: 875 KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT---TQVTSTTTQDTTPFK 931

Query: 828 TSSMDSQMLATSTMDSQMLATST 850
            +++ +  LA     ++   T+T
Sbjct: 932 ITTLKTTTLAPKVTTTKKTITTT 954



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 144/609 (23%), Positives = 221/609 (36%), Gaps = 79/609 (12%)

Query: 108 SKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVA- 166
           +K+  K  NKKK KK  + ++   +   SE++  S    +    S +  K  S  ++ A 
Sbjct: 92  TKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSS-SSSTIRKIKSSKNSAAN 150

Query: 167 ----LELPTRAFGPSETNESPAVVLEPPVVSMEVS--EPHILETLKPATKTAELSVVSTS 220
                +L  +    + T + P    +PPVV    S  +    +   P T T + + VSTS
Sbjct: 151 RELQKKLKVKDNKKNRTKKKPTP--KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTS 208

Query: 221 ---VISEQSEQSVAVMP------EPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQ 271
                ++      ++ P      E S+T   ++       TTT    S++     +   +
Sbjct: 209 PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 268

Query: 272 MKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPES 331
            +S+ K+        SK++    P A+       L    E PT   P+   STT   P  
Sbjct: 269 TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTP 327

Query: 332 SAIEALRLPEQPVDVPSEIADSSMTRPQE-LPELPKTTALELQESSVASAMELPGPPATS 390
           + I++   P  P +       S+ T P+E  P   K  A    +    +  + P P  T 
Sbjct: 328 TTIKSA--PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT- 384

Query: 391 MPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSV-TPVPQL 449
               +  P TP    P     P P  P     P P  P  P    P+ P P+   P P  
Sbjct: 385 ----KSAPTTPKEPAPTTPKKPAPTTP---KEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 437

Query: 450 SQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVE----LPEQPAVTVAMELTE 505
            +E    PAP+   +P    P+ P  A   P  P  T   E     P++PA T     T+
Sbjct: 438 PKE----PAPTAPKKPAPTTPKEP--APTTPKEPAPTTTKEPSPTTPKEPAPTT----TK 487

Query: 506 QPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALELPGQPS 565
              TTT  ++P   TT   P  P+         +P  T   E    P  TT    P +P+
Sbjct: 488 SAPTTT--KEPAPTTTKSAPTTPK---------EPSPTTTKE----PAPTT----PKEPA 528

Query: 566 VTGVPELPGLPSATRALELSGQPVATGALELPGPLMAAGALEFSGQSGAAGALELLGQPL 625
               P  P  P+ T   E    P  T   E P P         + +  A    +      
Sbjct: 529 ----PTTPKKPAPTTPKE----PAPTTPKE-PAPTTTKKPAPTTPKEPAPTTPKETAPTT 579

Query: 626 ATGVLELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYN 685
              +     +  AP  P +P  T   E++     TT E  T T  +    P+T    + N
Sbjct: 580 PKKLTPTTPEKLAPTTPEKPAPTTPEELA----PTTPEEPTPTTPEE-PAPTTPKAAAPN 634

Query: 686 TVAQELPTT 694
           T  +  PTT
Sbjct: 635 TPKEPAPTT 643



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 181/870 (20%), Positives = 302/870 (34%), Gaps = 131/870 (15%)

Query: 1149 LPPEEPPTMPPLPPEEPPMTPPL--PPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEE 1206
            L P       P P  E     P    P+EP   P  P E ++ T +   PT + S+P+  
Sbjct: 280  LAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAPT-- 335

Query: 1207 SVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVES 1266
            +  +P P  ++S  + P   P   +     P+     A  T  EP P    S   TP E 
Sbjct: 336  TPKEPAPTTTKSAPTTPKE-PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 394

Query: 1267 AVVAEEHEVVPERPVTCMVSE-TPAMSAEPT-VLASEP-PVMSETAETFDSMRASGHVAS 1323
            A         P++P      E  P    EPT     EP P   E A T     A      
Sbjct: 395  A------PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKK 448

Query: 1324 EVSTSLLVPAVTTPVL-AESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVT 1382
               T+   PA TTP   A +  + P+   P+  A    +S+  T  E +  T  +S+  T
Sbjct: 449  PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT-KSAPTT 507

Query: 1383 VLEPSVVTV--PEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440
              EPS  T   P P    EP   T   P      P+ P      +  +P+     P+ + 
Sbjct: 508  PKEPSPTTTKEPAPTTPKEPAPTTPKKPA-----PTTPKEPAPTTPKEPA-----PTTTK 557

Query: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500
            + +  T  EPA T  ++T     +    +TP  L  +                +  AP  
Sbjct: 558  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--------------PEKPAPTT 603

Query: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560
              +E+A  + EEP                             +E    T  AA  +   E
Sbjct: 604  P-EELAPTTPEEP------------------------TPTTPEEPAPTTPKAAAPNTPKE 638

Query: 1561 IGEEKILPTS--ETKQRTVLDTYPGVSEADAGETLSSTGPFAL-EPDATGTSKGIEFTTA 1617
                   PT+  E    T  +  P   +  A  T   T P  L EP  T   K      A
Sbjct: 639  PA-----PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 693

Query: 1618 STLSLVNKYDVDLSLTTQD---TEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNL 1674
             T             TT++   T  D    T+P G +    + P P        P     
Sbjct: 694  PT-------------TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT------PKEPAP 734

Query: 1675 VSKDTEEPLPVKESDQTLAALLSPKE----------SSGGEKEVPPPPKETLPDSGFSAN 1724
             +     P  +KE   T     +PKE          S+  +K  P  PKET P +     
Sbjct: 735  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 794

Query: 1725 IEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMP-ERASESS 1783
                 +     P  P       S     + P   + + +    ++P +S+ P  +A E+S
Sbjct: 795  PTTPKKPAPTTPETPPPTTSEVSTPTTTKEP---TTIHKSPDESTPELSAEPTPKALENS 851

Query: 1784 SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSE- 1842
             +E       V    T   +K        +K  +RD      +  +     K    T+E 
Sbjct: 852  PKEPG-----VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEK 906

Query: 1843 -SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS 1901
             + S+    +++  S  +Q  +  +    + ++ +   +  +++++  +    P+  +K 
Sbjct: 907  TTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP 966

Query: 1902 RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961
            ++R         N K    + + P++  +   P+  ++ +++ R R    +P+ R  T +
Sbjct: 967  KDR-------ATNSKATTPKPQKPTKAPKK--PTSTKKPKTMPRVRKPKTTPTPRKMTST 1017

Query: 1962 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRR 1991
                 P+  SR      +T +R ++TP+ +
Sbjct: 1018 MPELNPT--SRIAEAMLQTTTRPNQTPNSK 1045



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 75/343 (21%), Positives = 113/343 (32%), Gaps = 15/343 (4%)

Query: 1141 TEAYMVPPLPPEEPPTMPP-----LPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTW 1195
            T     P  P E  PT P       P E  P TP  P    P+ PA  T++ A T     
Sbjct: 382  TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP 441

Query: 1196 PTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEP 1255
                P  P+  +  +P P   +      +  P+  +     P+   S A  T  EP P  
Sbjct: 442  APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS-APTTTKEPAPTT 500

Query: 1256 ESSITLTPVESA--VVAEEHEVVPERPV-TCMVSETPAMSAEPTVLASEPPVMSETAETF 1312
              S   TP E +     E     P+ P  T      P    EP     + P  + T +  
Sbjct: 501  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 560

Query: 1313 DSMRASGHVASEVSTSLLVPAVTTPV----LAESILEPPAMAAPESSAMAVLESSAVTVL 1368
             +        +   T+   P   TP     LA +  E PA   PE  A    E    T  
Sbjct: 561  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 620

Query: 1369 ESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQ 1428
            E    T  +++     +    T P+ P    P       P  +A  P+ P      ++ +
Sbjct: 621  EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA--PTTPKGTAPTTLKE 678

Query: 1429 PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
            P+    +     + +  T  EP  T  ++      +    +TP
Sbjct: 679  PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP 721



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 95/378 (25%), Positives = 146/378 (38%), Gaps = 42/378 (11%)

Query: 1128 AADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLP--PEEPPMTPP------LPPEEPPEG 1179
            +A + T     T T++    P  P    T  P P  P+EP  T P       P E  P  
Sbjct: 488  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 547

Query: 1180 PALPTEQSALTAENTWPTE-VPSSPSEESVSQPE--PPVSQSEIS----EPSAVPTDYSV 1232
            P  P   +      T P E  P++P E + + P+   P +  +++    E  A  T   +
Sbjct: 548  PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 607

Query: 1233 SASDPSVLVSEAAVTVPE--PPPEPESSITLTPVESAVVA--EEHEVVPERPVTCMVSET 1288
            + + P     E   T PE   P  P+++   TP E A     E     P+ P       T
Sbjct: 608  APTTP----EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP----APTT 659

Query: 1289 PAMSAEPTVLASEPPVMSETAETFDSMRASGHVA-----SEVSTSLLVPAVTTPV-LAES 1342
            P  +A  T   + P  + E A T     A   +A        ST+   PA TTP   A +
Sbjct: 660  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 719

Query: 1343 ILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDY 1402
              + PA   P+  A    + +A T L+    T  +      L P+    P      +P  
Sbjct: 720  TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 779

Query: 1403 VTIPVPVVSALEPSVPVLEPAVSVLQ---PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQ 1459
             T   P  +A  P+ P  EPA +  +   P+   + P  + + ST T ++   T+ +   
Sbjct: 780  TT---PKETA--PTTP-KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 833

Query: 1460 VIPTEVAIESTPMILESS 1477
                E++ E TP  LE+S
Sbjct: 834  ESTPELSAEPTPKALENS 851



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 86/333 (25%), Positives = 124/333 (37%), Gaps = 64/333 (19%)

Query: 1148 PLPPEEP-PTMP----PLPPEEP-PMTP----PLPPEEPPEGPALPTEQSALTAENTWPT 1197
            P  PEEP PT P    P  P+EP P TP    P  P+EP   P  P E +  T + T PT
Sbjct: 617  PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP--APTTPKETAPTTPKGTAPT 674

Query: 1198 EVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP-PPEPE 1256
             +     E + + P+ P  +      +  PT  +     P+     A  T  EP P  P+
Sbjct: 675  TL----KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 730

Query: 1257 SSITLTPVESA--VVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDS 1314
                 TP  +A   + E     P++P    ++  P  +  PT   S+ P  +   ET   
Sbjct: 731  EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA--PTTTKGPTSTTSDKPAPTTPKET--- 785

Query: 1315 MRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVT 1374
                              A TTP       + PA   P+  A    E+   T  E ST T
Sbjct: 786  ------------------APTTP-------KEPAPTTPKKPAPTTPETPPPTTSEVSTPT 820

Query: 1375 VLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVV---SALEPSVPVLE-PAVSVLQPS 1430
                   T  EP+  T+ + P  + P+    P P     S  EP VP  + PA +  +P 
Sbjct: 821  -------TTKEPT--TIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT--KPE 869

Query: 1431 MIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPT 1463
            M  +    + +    T  E      + T+   T
Sbjct: 870  MTTTAKDKTTERDLRTTPETTTAAPKMTKETAT 902



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 122/526 (23%), Positives = 184/526 (34%), Gaps = 70/526 (13%)

Query: 1147 PPLPPEEPPTMP----PLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSS 1202
            P  P E  PT P    P  P+EP   P  P E     P    E S  T +   PT   S+
Sbjct: 435  PTTPKEPAPTAPKKPAPTTPKEP--APTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSA 489

Query: 1203 PSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP-PPEPESSITL 1261
            P+  +  +P P  ++S  + P             P+     A  T  EP P  P+     
Sbjct: 490  PT--TTKEPAPTTTKSAPTTP---------KEPSPTTTKEPAPTTPKEPAPTTPKKPAPT 538

Query: 1262 TPVESAVVAEEHEVVPERPV-TCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH 1320
            TP E A         P+ P  T      P    EP      P    ETA T         
Sbjct: 539  TPKEPA------PTTPKEPAPTTTKKPAPTTPKEPA-----PTTPKETAPTTPKKLTPTT 587

Query: 1321 VASEVSTSLLVPAVTTP-VLAESILEPPAMAAPESSAMAVLESSAV-TVLESSTVTVLES 1378
                  T+   PA TTP  LA +  E P    PE  A    +++A  T  E +  T  E 
Sbjct: 588  PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 647

Query: 1379 STVTVLEPSVVTVPE----------PPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQ 1428
            +  T  EP+  T  E          P  + EP   T   P    L P+      + +  +
Sbjct: 648  APTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 707

Query: 1429 PSMIV---SEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMK 1485
            P+      + P+   + +  T  EPA T  + T     +    +TP       ++    K
Sbjct: 708  PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 767

Query: 1486 GINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEM 1545
            G   ++ D+  AP    +E A  + +EP      K      E        ++     K  
Sbjct: 768  GPTSTTSDKP-APTT-PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK-- 823

Query: 1546 EHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDA 1605
            E  T+  +      E+  E   PT +  + +  +  PGV         ++  P A +P+ 
Sbjct: 824  EPTTIHKSPDESTPELSAE---PTPKALENSPKE--PGVP--------TTKTPAATKPEM 870

Query: 1606 TGTSKGIEF-----TTASTLSLVNKYDVDLSLTTQDTEHDMVISTS 1646
            T T+K         TT  T +   K   + + TT+ T    + +T+
Sbjct: 871  TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 916



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 97/454 (21%), Positives = 155/454 (34%), Gaps = 37/454 (8%)

Query: 1035 SAYERSMMSAYERSMMSPMAERS--MMSAYERSMMSAYERSMMSPMADRSMMSMGADRSM 1092
            S   +++ S  +RS   P  +++  ++ + E +   +   +  S  +  S  S    R +
Sbjct: 82   SGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKI 141

Query: 1093 MSSY-SAADRSMMSSYSAADRSMMSSY--------TADRSMMSMAADSYTDSYTDTYTEA 1143
             SS  SAA+R +       D     +           D +   +    +  +  DT T  
Sbjct: 142  KSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQ 201

Query: 1144 YMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSP 1203
            +      P+   T  P+ P   P  PP           +  E +  T E T   +  S+ 
Sbjct: 202  HNKVSTSPKIT-TAKPINPR--PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTD 258

Query: 1204 SEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEA--AVTVPEPPPEPESSITL 1261
             +E  +  +   S  + S     PT   ++   P    +    A+T P+ P         
Sbjct: 259  GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPT------ 312

Query: 1262 TPVESAVVAEEHEVVPERPVTCMVSETPAMSAEP--TVLASEPPVMSETAETFDSMRASG 1319
            TP E A         P+ P    +   P    EP  T   S P    E A T     A  
Sbjct: 313  TPKEPA------STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 366

Query: 1320 HVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESS 1379
                   T+   PA TT   A +  + PA   P+  A    +  A T  +  T T  +  
Sbjct: 367  TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP 426

Query: 1380 TVTVLEPSVVTVPEPPVVA--EPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPS 1437
              T  EP+  T  EP   A  +P   T   P  +  +   P      S   P     EP+
Sbjct: 427  APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTP----KEPA 482

Query: 1438 VSVQEST-VTVSEPAVTVSEQTQVIPTEVAIEST 1470
             +  +S   T  EPA T ++     P E +  +T
Sbjct: 483  PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 516



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 63/267 (23%), Positives = 97/267 (36%), Gaps = 30/267 (11%)

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSE-- 1205
            P P     T P  P E  P TP  P    PE P   T + +       PT +  SP E  
Sbjct: 777  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 836

Query: 1206 -ESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPV 1264
             E  ++P P   ++   EP  VPT  + +A+ P +  +    T        E  +  TP 
Sbjct: 837  PELSAEPTPKALENSPKEPG-VPTTKTPAATKPEMTTTAKDKTT-------ERDLRTTP- 887

Query: 1265 ESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASE 1324
            E+   A +        +T   + T   + E  + A+   V S T +     +      + 
Sbjct: 888  ETTTAAPK--------MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK-----ITT 934

Query: 1325 VSTSLLVPAVTTPVLAESILEPPAMAAPESSAM---AVLESSAVTVLESSTVTVLESSTV 1381
            + T+ L P VTT    ++I     M  PE +A        S A T          +  T 
Sbjct: 935  LKTTTLAPKVTT--TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 992

Query: 1382 TVLEPSVVTVPEPPVVAEPDYVTIPVP 1408
            T    ++  V +P     P  +T  +P
Sbjct: 993  TKKPKTMPRVRKPKTTPTPRKMTSTMP 1019



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 13/133 (9%)

Query: 1173 PEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSV 1232
            PEE  +     T   A T +   PT+ P  P     +  + P +   + +P   PT   +
Sbjct: 960  PEETAKPKDRATNSKATTPKPQKPTKAPKKP-----TSTKKPKTMPRVRKPKTTPTPRKM 1014

Query: 1233 SAS----DPSVLVSEAAV-TVPEPPPEPESSITLTPVESAVVAEEHEVVPE---RPVTCM 1284
            +++    +P+  ++EA + T   P   P S +     +S          P    RP   M
Sbjct: 1015 TSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFM 1074

Query: 1285 VSETPAMSAEPTV 1297
               TP M   P V
Sbjct: 1075 PEVTPDMDYLPRV 1087


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 91.7 bits (226), Expect = 8e-18
 Identities = 174/803 (21%), Positives = 282/803 (35%), Gaps = 100/803 (12%)

Query: 80  KPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESK 139
           +P L   S  S+  S+  +    + TK++    K  +   K+K    K+      +S  K
Sbjct: 261 RPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE-----TQSIEK 315

Query: 140 TKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSMEVSEP 199
           T + D                 P++  L  PT       T + PA+            EP
Sbjct: 316 TSAKD---------------LAPTSKVLAKPTPK--AETTTKGPALTTP--------KEP 350

Query: 200 HILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTT---LV 256
                 +PA+ T +    +T     +S  +    P P+ TK   +    P PTTT     
Sbjct: 351 TPTTPKEPASTTPKEPTPTTI----KSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAP 406

Query: 257 LKSSEPVVTMSVEYQMKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEV 316
               EP  T + E    +  KS  +T  EP+     +P      EP+ T   + + PT  
Sbjct: 407 TTPKEPAPTTTKE-PAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPT---TPKEPTPT 462

Query: 317 YP-EPSTSTTMDFPESSAIEALRLPEQPVDV-PSEIADSSMTRP------QELPELPKTT 368
            P EP+ +T    P +    A   P++P    P E A ++   P      +  P  PK  
Sbjct: 463 TPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEP 522

Query: 369 ALELQESSVASAMELPGPPAT-SMPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPEL 427
           A    +S+  +  E P P  T S P     P     + P P+ TP    P     P P  
Sbjct: 523 APTTTKSAPTTTKE-PAPTTTKSAPTTPKEPSPTTTKEPAPT-TPKEPAPTTPKKPAPTT 580

Query: 428 PGPPATAVPELPGPSVTPVPQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTA 487
           P  PA   P+ P P+ T  P  +   P  PAP+    P +  P  P   ++L        
Sbjct: 581 PKEPAPTTPKEPAPTTTKKP--APTTPKEPAPT---TPKETAPTTP---KKLTPTTPEKL 632

Query: 488 AVELPEQPAVTVAMELT----EQPVTTTELEQPVGMT----TVEHPGHPEVTTATGLLGQ 539
           A   PE+PA T   EL     E+P  TT  E+P   T        P  P  TT      +
Sbjct: 633 APTTPEKPAPTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPK----E 687

Query: 540 PEATMVLELPGQPVATTALE-LPGQPSVTG-------VPELPGLPSATRALELSGQPVAT 591
           P  T     P +P  TT  E  P  P  T         P  P  P+       + +   +
Sbjct: 688 PAPT----TPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTS 743

Query: 592 GALELPGPLMAAGALEFSGQSGAAGALELLGQPLATGVLELPGQPGAPELPGQPVATVAL 651
              + P P    G    + +  A    +        G      +  AP  P +P      
Sbjct: 744 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPK--- 800

Query: 652 EISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVDPLMAP 711
               +   TT++  T T S     P+T    +  T  +  PTT       T    P    
Sbjct: 801 ----ELAPTTTKGPTSTTSDK-PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTS 855

Query: 712 ESHILASNTMETHILASNTMDSQMLAS----NTMDSQMLASNTMDSQMLASSTMDSQMLA 767
           E     +    T I  S    +  L++      +++         ++  A++  +    A
Sbjct: 856 EVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTA 915

Query: 768 TSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDSQMLATSSMDSQMLA 827
                 + L T+   +      T ++      + +S++ AT+   +Q+ +T++ D+    
Sbjct: 916 KDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT---TQVTSTTTQDTTPFK 972

Query: 828 TSSMDSQMLATSTMDSQMLATST 850
            +++ +  LA     ++   T+T
Sbjct: 973 ITTLKTTTLAPKVTTTKKTITTT 995



 Score = 85.5 bits (210), Expect = 6e-16
 Identities = 144/609 (23%), Positives = 221/609 (36%), Gaps = 79/609 (12%)

Query: 108 SKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVA- 166
           +K+  K  NKKK KK  + ++   +   SE++  S    +    S +  K  S  ++ A 
Sbjct: 133 TKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSS-SSSTIRKIKSSKNSAAN 191

Query: 167 ----LELPTRAFGPSETNESPAVVLEPPVVSMEVS--EPHILETLKPATKTAELSVVSTS 220
                +L  +    + T + P    +PPVV    S  +    +   P T T + + VSTS
Sbjct: 192 RELQKKLKVKDNKKNRTKKKPTP--KPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTS 249

Query: 221 ---VISEQSEQSVAVMP------EPSMTKILDSFAAAPVPTTTLVLKSSEPVVTMSVEYQ 271
                ++      ++ P      E S+T   ++       TTT    S++     +   +
Sbjct: 250 PKITTAKPINPRPSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKE 309

Query: 272 MKSVLKSVESTSPEPSKIMLVEPPVAKVLEPSETLVVSSETPTEVYPEPSTSTTMDFPES 331
            +S+ K+        SK++    P A+       L    E PT   P+   STT   P  
Sbjct: 310 TQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTP 368

Query: 332 SAIEALRLPEQPVDVPSEIADSSMTRPQE-LPELPKTTALELQESSVASAMELPGPPATS 390
           + I++   P  P +       S+ T P+E  P   K  A    +    +  + P P  T 
Sbjct: 369 TTIKSA--PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTT- 425

Query: 391 MPELQGPPVTPVLELPGPSATPVPELPGPLSTPVPELPGPPATAVPELPGPSV-TPVPQL 449
               +  P TP    P     P P  P     P P  P  P    P+ P P+   P P  
Sbjct: 426 ----KSAPTTPKEPAPTTPKKPAPTTP---KEPAPTTPKEPTPTTPKEPAPTTKEPAPTT 478

Query: 450 SQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVE----LPEQPAVTVAMELTE 505
            +E    PAP+   +P    P+ P  A   P  P  T   E     P++PA T     T+
Sbjct: 479 PKE----PAPTAPKKPAPTTPKEP--APTTPKEPAPTTTKEPSPTTPKEPAPTT----TK 528

Query: 506 QPVTTTELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALELPGQPS 565
              TTT  ++P   TT   P  P+         +P  T   E    P  TT    P +P+
Sbjct: 529 SAPTTT--KEPAPTTTKSAPTTPK---------EPSPTTTKE----PAPTT----PKEPA 569

Query: 566 VTGVPELPGLPSATRALELSGQPVATGALELPGPLMAAGALEFSGQSGAAGALELLGQPL 625
               P  P  P+ T   E    P  T   E P P         + +  A    +      
Sbjct: 570 ----PTTPKKPAPTTPKE----PAPTTPKE-PAPTTTKKPAPTTPKEPAPTTPKETAPTT 620

Query: 626 ATGVLELPGQPGAPELPGQPVATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYN 685
              +     +  AP  P +P  T   E++     TT E  T T  +    P+T    + N
Sbjct: 621 PKKLTPTTPEKLAPTTPEKPAPTTPEELA----PTTPEEPTPTTPEE-PAPTTPKAAAPN 675

Query: 686 TVAQELPTT 694
           T  +  PTT
Sbjct: 676 TPKEPAPTT 684



 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 181/870 (20%), Positives = 302/870 (34%), Gaps = 131/870 (15%)

Query: 1149 LPPEEPPTMPPLPPEEPPMTPPL--PPEEPPEGPALPTEQSALTAENTWPTEVPSSPSEE 1206
            L P       P P  E     P    P+EP   P  P E ++ T +   PT + S+P+  
Sbjct: 321  LAPTSKVLAKPTPKAETTTKGPALTTPKEPT--PTTPKEPASTTPKEPTPTTIKSAPT-- 376

Query: 1207 SVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPVES 1266
            +  +P P  ++S  + P   P   +     P+     A  T  EP P    S   TP E 
Sbjct: 377  TPKEPAPTTTKSAPTTPKE-PAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 435

Query: 1267 AVVAEEHEVVPERPVTCMVSE-TPAMSAEPT-VLASEP-PVMSETAETFDSMRASGHVAS 1323
            A         P++P      E  P    EPT     EP P   E A T     A      
Sbjct: 436  A------PTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKK 489

Query: 1324 EVSTSLLVPAVTTPVL-AESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVT 1382
               T+   PA TTP   A +  + P+   P+  A    +S+  T  E +  T  +S+  T
Sbjct: 490  PAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTT-KSAPTT 548

Query: 1383 VLEPSVVTV--PEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSV 1440
              EPS  T   P P    EP   T   P      P+ P      +  +P+     P+ + 
Sbjct: 549  PKEPSPTTTKEPAPTTPKEPAPTTPKKPA-----PTTPKEPAPTTPKEPA-----PTTTK 598

Query: 1441 QESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMKGINLSSGDQNLAPEI 1500
            + +  T  EPA T  ++T     +    +TP  L  +                +  AP  
Sbjct: 599  KPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTT--------------PEKPAPTT 644

Query: 1501 GMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEMEHNTVCAAGTSPVGE 1560
              +E+A  + EEP                             +E    T  AA  +   E
Sbjct: 645  P-EELAPTTPEEP------------------------TPTTPEEPAPTTPKAAAPNTPKE 679

Query: 1561 IGEEKILPTS--ETKQRTVLDTYPGVSEADAGETLSSTGPFAL-EPDATGTSKGIEFTTA 1617
                   PT+  E    T  +  P   +  A  T   T P  L EP  T   K      A
Sbjct: 680  PA-----PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELA 734

Query: 1618 STLSLVNKYDVDLSLTTQD---TEHDMVISTSPSGGSEADIEGPLPAKDIHLDLPSNNNL 1674
             T             TT++   T  D    T+P G +    + P P        P     
Sbjct: 735  PT-------------TTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTT------PKEPAP 775

Query: 1675 VSKDTEEPLPVKESDQTLAALLSPKE----------SSGGEKEVPPPPKETLPDSGFSAN 1724
             +     P  +KE   T     +PKE          S+  +K  P  PKET P +     
Sbjct: 776  TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPA 835

Query: 1725 IEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDRSAASPVVSSMP-ERASESS 1783
                 +     P  P       S     + P   + + +    ++P +S+ P  +A E+S
Sbjct: 836  PTTPKKPAPTTPETPPPTTSEVSTPTTTKEP---TTIHKSPDESTPELSAEPTPKALENS 892

Query: 1784 SEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTSE- 1842
             +E       V    T   +K        +K  +RD      +  +     K    T+E 
Sbjct: 893  PKEPG-----VPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEK 947

Query: 1843 -SRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS 1901
             + S+    +++  S  +Q  +  +    + ++ +   +  +++++  +    P+  +K 
Sbjct: 948  TTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKP 1007

Query: 1902 RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPS 1961
            ++R         N K    + + P++  +   P+  ++ +++ R R    +P+ R  T +
Sbjct: 1008 KDR-------ATNSKATTPKPQKPTKAPKK--PTSTKKPKTMPRVRKPKTTPTPRKMTST 1058

Query: 1962 RRSRTPSRRSRTPSRRSRTPSRRSRTPSRR 1991
                 P+  SR      +T +R ++TP+ +
Sbjct: 1059 MPELNPT--SRIAEAMLQTTTRPNQTPNSK 1086



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 75/343 (21%), Positives = 113/343 (32%), Gaps = 15/343 (4%)

Query: 1141 TEAYMVPPLPPEEPPTMPP-----LPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTW 1195
            T     P  P E  PT P       P E  P TP  P    P+ PA  T++ A T     
Sbjct: 423  TTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEP 482

Query: 1196 PTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEP 1255
                P  P+  +  +P P   +      +  P+  +     P+   S A  T  EP P  
Sbjct: 483  APTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKS-APTTTKEPAPTT 541

Query: 1256 ESSITLTPVESA--VVAEEHEVVPERPV-TCMVSETPAMSAEPTVLASEPPVMSETAETF 1312
              S   TP E +     E     P+ P  T      P    EP     + P  + T +  
Sbjct: 542  TKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPA 601

Query: 1313 DSMRASGHVASEVSTSLLVPAVTTPV----LAESILEPPAMAAPESSAMAVLESSAVTVL 1368
             +        +   T+   P   TP     LA +  E PA   PE  A    E    T  
Sbjct: 602  PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTP 661

Query: 1369 ESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQ 1428
            E    T  +++     +    T P+ P    P       P  +A  P+ P      ++ +
Sbjct: 662  EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETA--PTTPKGTAPTTLKE 719

Query: 1429 PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTP 1471
            P+    +     + +  T  EP  T  ++      +    +TP
Sbjct: 720  PAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTP 762



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 95/378 (25%), Positives = 146/378 (38%), Gaps = 42/378 (11%)

Query: 1128 AADSYTDSYTDTYTEAYMVPPLPPEEPPTMPPLP--PEEPPMTPP------LPPEEPPEG 1179
            +A + T     T T++    P  P    T  P P  P+EP  T P       P E  P  
Sbjct: 529  SAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTT 588

Query: 1180 PALPTEQSALTAENTWPTE-VPSSPSEESVSQPE--PPVSQSEIS----EPSAVPTDYSV 1232
            P  P   +      T P E  P++P E + + P+   P +  +++    E  A  T   +
Sbjct: 589  PKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEEL 648

Query: 1233 SASDPSVLVSEAAVTVPE--PPPEPESSITLTPVESAVVA--EEHEVVPERPVTCMVSET 1288
            + + P     E   T PE   P  P+++   TP E A     E     P+ P       T
Sbjct: 649  APTTP----EEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP----APTT 700

Query: 1289 PAMSAEPTVLASEPPVMSETAETFDSMRASGHVA-----SEVSTSLLVPAVTTPV-LAES 1342
            P  +A  T   + P  + E A T     A   +A        ST+   PA TTP   A +
Sbjct: 701  PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 760

Query: 1343 ILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDY 1402
              + PA   P+  A    + +A T L+    T  +      L P+    P      +P  
Sbjct: 761  TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 820

Query: 1403 VTIPVPVVSALEPSVPVLEPAVSVLQ---PSMIVSEPSVSVQESTVTVSEPAVTVSEQTQ 1459
             T   P  +A  P+ P  EPA +  +   P+   + P  + + ST T ++   T+ +   
Sbjct: 821  TT---PKETA--PTTP-KEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPD 874

Query: 1460 VIPTEVAIESTPMILESS 1477
                E++ E TP  LE+S
Sbjct: 875  ESTPELSAEPTPKALENS 892



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 86/333 (25%), Positives = 124/333 (37%), Gaps = 64/333 (19%)

Query: 1148 PLPPEEP-PTMP----PLPPEEP-PMTP----PLPPEEPPEGPALPTEQSALTAENTWPT 1197
            P  PEEP PT P    P  P+EP P TP    P  P+EP   P  P E +  T + T PT
Sbjct: 658  PTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEP--APTTPKETAPTTPKGTAPT 715

Query: 1198 EVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP-PPEPE 1256
             +     E + + P+ P  +      +  PT  +     P+     A  T  EP P  P+
Sbjct: 716  TL----KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPK 771

Query: 1257 SSITLTPVESA--VVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDS 1314
                 TP  +A   + E     P++P    ++  P  +  PT   S+ P  +   ET   
Sbjct: 772  EPAPTTPKGTAPTTLKEPAPTTPKKPAPKELA--PTTTKGPTSTTSDKPAPTTPKET--- 826

Query: 1315 MRASGHVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVT 1374
                              A TTP       + PA   P+  A    E+   T  E ST T
Sbjct: 827  ------------------APTTP-------KEPAPTTPKKPAPTTPETPPPTTSEVSTPT 861

Query: 1375 VLESSTVTVLEPSVVTVPEPPVVAEPDYVTIPVPVV---SALEPSVPVLE-PAVSVLQPS 1430
                   T  EP+  T+ + P  + P+    P P     S  EP VP  + PA +  +P 
Sbjct: 862  -------TTKEPT--TIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAAT--KPE 910

Query: 1431 MIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPT 1463
            M  +    + +    T  E      + T+   T
Sbjct: 911  MTTTAKDKTTERDLRTTPETTTAAPKMTKETAT 943



 Score = 65.5 bits (158), Expect = 6e-10
 Identities = 122/526 (23%), Positives = 184/526 (34%), Gaps = 70/526 (13%)

Query: 1147 PPLPPEEPPTMP----PLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSS 1202
            P  P E  PT P    P  P+EP   P  P E     P    E S  T +   PT   S+
Sbjct: 476  PTTPKEPAPTAPKKPAPTTPKEP--APTTPKE---PAPTTTKEPSPTTPKEPAPTTTKSA 530

Query: 1203 PSEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEP-PPEPESSITL 1261
            P+  +  +P P  ++S  + P             P+     A  T  EP P  P+     
Sbjct: 531  PT--TTKEPAPTTTKSAPTTP---------KEPSPTTTKEPAPTTPKEPAPTTPKKPAPT 579

Query: 1262 TPVESAVVAEEHEVVPERPV-TCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGH 1320
            TP E A         P+ P  T      P    EP      P    ETA T         
Sbjct: 580  TPKEPA------PTTPKEPAPTTTKKPAPTTPKEPA-----PTTPKETAPTTPKKLTPTT 628

Query: 1321 VASEVSTSLLVPAVTTP-VLAESILEPPAMAAPESSAMAVLESSAV-TVLESSTVTVLES 1378
                  T+   PA TTP  LA +  E P    PE  A    +++A  T  E +  T  E 
Sbjct: 629  PEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEP 688

Query: 1379 STVTVLEPSVVTVPE----------PPVVAEPDYVTIPVPVVSALEPSVPVLEPAVSVLQ 1428
            +  T  EP+  T  E          P  + EP   T   P    L P+      + +  +
Sbjct: 689  APTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDK 748

Query: 1429 PSMIV---SEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIESTPMILESSIMSSHVMK 1485
            P+      + P+   + +  T  EPA T  + T     +    +TP       ++    K
Sbjct: 749  PAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTK 808

Query: 1486 GINLSSGDQNLAPEIGMQEIALHSGEEPHAEEHLKGDFYESEHGINIDLNINNHLIAKEM 1545
            G   ++ D+  AP    +E A  + +EP      K      E        ++     K  
Sbjct: 809  GPTSTTSDKP-APTT-PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTK-- 864

Query: 1546 EHNTVCAAGTSPVGEIGEEKILPTSETKQRTVLDTYPGVSEADAGETLSSTGPFALEPDA 1605
            E  T+  +      E+  E   PT +  + +  +  PGV         ++  P A +P+ 
Sbjct: 865  EPTTIHKSPDESTPELSAE---PTPKALENSPKE--PGVP--------TTKTPAATKPEM 911

Query: 1606 TGTSKGIEF-----TTASTLSLVNKYDVDLSLTTQDTEHDMVISTS 1646
            T T+K         TT  T +   K   + + TT+ T    + +T+
Sbjct: 912  TTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATT 957



 Score = 62.4 bits (150), Expect = 5e-09
 Identities = 97/454 (21%), Positives = 155/454 (34%), Gaps = 37/454 (8%)

Query: 1035 SAYERSMMSAYERSMMSPMAERS--MMSAYERSMMSAYERSMMSPMADRSMMSMGADRSM 1092
            S   +++ S  +RS   P  +++  ++ + E +   +   +  S  +  S  S    R +
Sbjct: 123  SGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSSSSSSTIRKI 182

Query: 1093 MSSY-SAADRSMMSSYSAADRSMMSSY--------TADRSMMSMAADSYTDSYTDTYTEA 1143
             SS  SAA+R +       D     +           D +   +    +  +  DT T  
Sbjct: 183  KSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGSGLDNGDFKVTTPDTSTTQ 242

Query: 1144 YMVPPLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSP 1203
            +      P+   T  P+ P   P  PP           +  E +  T E T   +  S+ 
Sbjct: 243  HNKVSTSPKIT-TAKPINPR--PSLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTD 299

Query: 1204 SEESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEA--AVTVPEPPPEPESSITL 1261
             +E  +  +   S  + S     PT   ++   P    +    A+T P+ P         
Sbjct: 300  GKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPT------ 353

Query: 1262 TPVESAVVAEEHEVVPERPVTCMVSETPAMSAEP--TVLASEPPVMSETAETFDSMRASG 1319
            TP E A         P+ P    +   P    EP  T   S P    E A T     A  
Sbjct: 354  TPKEPA------STTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPT 407

Query: 1320 HVASEVSTSLLVPAVTTPVLAESILEPPAMAAPESSAMAVLESSAVTVLESSTVTVLESS 1379
                   T+   PA TT   A +  + PA   P+  A    +  A T  +  T T  +  
Sbjct: 408  TPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEP 467

Query: 1380 TVTVLEPSVVTVPEPPVVA--EPDYVTIPVPVVSALEPSVPVLEPAVSVLQPSMIVSEPS 1437
              T  EP+  T  EP   A  +P   T   P  +  +   P      S   P     EP+
Sbjct: 468  APTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTP----KEPA 523

Query: 1438 VSVQEST-VTVSEPAVTVSEQTQVIPTEVAIEST 1470
             +  +S   T  EPA T ++     P E +  +T
Sbjct: 524  PTTTKSAPTTTKEPAPTTTKSAPTTPKEPSPTTT 557



 Score = 55.1 bits (131), Expect = 8e-07
 Identities = 63/267 (23%), Positives = 97/267 (36%), Gaps = 30/267 (11%)

Query: 1148 PLPPEEPPTMPPLPPEEPPMTPPLPPEEPPEGPALPTEQSALTAENTWPTEVPSSPSE-- 1205
            P P     T P  P E  P TP  P    PE P   T + +       PT +  SP E  
Sbjct: 818  PAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDEST 877

Query: 1206 -ESVSQPEPPVSQSEISEPSAVPTDYSVSASDPSVLVSEAAVTVPEPPPEPESSITLTPV 1264
             E  ++P P   ++   EP  VPT  + +A+ P +  +    T        E  +  TP 
Sbjct: 878  PELSAEPTPKALENSPKEPG-VPTTKTPAATKPEMTTTAKDKTT-------ERDLRTTP- 928

Query: 1265 ESAVVAEEHEVVPERPVTCMVSETPAMSAEPTVLASEPPVMSETAETFDSMRASGHVASE 1324
            E+   A +        +T   + T   + E  + A+   V S T +     +      + 
Sbjct: 929  ETTTAAPK--------MTKETATTTEKTTESKITATTTQVTSTTTQDTTPFK-----ITT 975

Query: 1325 VSTSLLVPAVTTPVLAESILEPPAMAAPESSAM---AVLESSAVTVLESSTVTVLESSTV 1381
            + T+ L P VTT    ++I     M  PE +A        S A T          +  T 
Sbjct: 976  LKTTTLAPKVTT--TKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTS 1033

Query: 1382 TVLEPSVVTVPEPPVVAEPDYVTIPVP 1408
            T    ++  V +P     P  +T  +P
Sbjct: 1034 TKKPKTMPRVRKPKTTPTPRKMTSTMP 1060



 Score = 32.7 bits (73), Expect = 4.2
 Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 13/133 (9%)

Query: 1173 PEEPPEGPALPTEQSALTAENTWPTEVPSSPSEESVSQPEPPVSQSEISEPSAVPTDYSV 1232
            PEE  +     T   A T +   PT+ P  P     +  + P +   + +P   PT   +
Sbjct: 1001 PEETAKPKDRATNSKATTPKPQKPTKAPKKP-----TSTKKPKTMPRVRKPKTTPTPRKM 1055

Query: 1233 SAS----DPSVLVSEAAV-TVPEPPPEPESSITLTPVESAVVAEEHEVVPE---RPVTCM 1284
            +++    +P+  ++EA + T   P   P S +     +S          P    RP   M
Sbjct: 1056 TSTMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFM 1115

Query: 1285 VSETPAMSAEPTV 1297
               TP M   P V
Sbjct: 1116 PEVTPDMDYLPRV 1128


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.122    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,638,236
Number of Sequences: 37866
Number of extensions: 5676811
Number of successful extensions: 115779
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 952
Number of HSP's successfully gapped in prelim test: 2209
Number of HSP's that attempted gapping in prelim test: 33131
Number of HSP's gapped (non-prelim): 36657
length of query: 2303
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2185
effective length of database: 13,779,330
effective search space: 30107836050
effective search space used: 30107836050
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.