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Search of human proteins with 21040235
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
(384 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 789 0.0
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 463 e-130
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 353 2e-97
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 353 2e-97
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 345 3e-95
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 345 3e-95
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 345 3e-95
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 345 3e-95
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 286 2e-77
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 283 1e-76
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 262 4e-70
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 246 2e-65
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 244 7e-65
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 213 2e-55
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 213 2e-55
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 213 2e-55
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 213 2e-55
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 213 2e-55
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 213 2e-55
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 211 7e-55
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 211 1e-54
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 211 1e-54
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 199 3e-51
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 197 2e-50
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 195 7e-50
gi|4502741 cyclin-dependent kinase 6 [Homo sapiens] 195 7e-50
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens] 192 6e-49
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 191 9e-49
gi|4502735 cyclin-dependent kinase 4 [Homo sapiens] 191 1e-48
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 187 1e-47
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 789 bits (2038), Expect = 0.0
Identities = 384/384 (100%), Positives = 384/384 (100%)
Query: 1 MTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGE 60
MTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGE
Sbjct: 1 MTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGE 60
Query: 61 GSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTK 120
GSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTK
Sbjct: 61 GSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTK 120
Query: 121 ETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLL 180
ETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLL
Sbjct: 121 ETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLL 180
Query: 181 ISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFI 240
ISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFI
Sbjct: 181 ISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFI 240
Query: 241 EMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVW 300
EMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVW
Sbjct: 241 EMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVW 300
Query: 301 NRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRL 360
NRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRL
Sbjct: 301 NRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRL 360
Query: 361 KPEMCDLLASYQKGHHPAQFSKCW 384
KPEMCDLLASYQKGHHPAQFSKCW
Sbjct: 361 KPEMCDLLASYQKGHHPAQFSKCW 384
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 463 bits (1191), Expect = e-130
Identities = 224/330 (67%), Positives = 270/330 (81%)
Query: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
FG A SY LEKLGEGSYATVYKG S++NG+LVALKVI + EEG PFTAIREASLLKGL
Sbjct: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170
Query: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
KHANIVLLHDIIHTKETLT VFEY+HTDL QYM +HPGGLHP NV+LF+FQLLRGL+YIH
Sbjct: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
Query: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
+++LHRDLKPQNLLIS GELKLADFGLARAKS+PS TYS+EVVTLWYRPPD LLG+TE
Sbjct: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
YS+ LD+WG GCIF+EM QG FPG+ +I +QLE+I+ VLG P EDTWPGV LP++ P
Sbjct: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
E F L + ++L WN+L V AEDLAS++L+ P++R+SAQ AL H+YFS LP +L++
Sbjct: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410
Query: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGH 375
L D S+FTV VRL+PE + + ++ K +
Sbjct: 411 LTDMSSIFTVPNVRLQPEAGESMRAFGKNN 440
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 353 bits (905), Expect = 2e-97
Identities = 180/333 (54%), Positives = 240/333 (72%), Gaps = 3/333 (0%)
Query: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
FG +Y+ L+KLGEG+YATVYKG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 165 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 224
Query: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
KHANIV LHDIIHT+++LT VFEY+ DL QY+ ++ HNV+LF+FQLLRGLAY H
Sbjct: 225 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 284
Query: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
Q VLHRDLKPQNLLI+ GELKLADFGLARAKSIP++TYS+EVVTLWYRPPD LLG+T+
Sbjct: 285 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 344
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
YS+++D+WG GCIF EM G+PLFPG S + EQL I+ +LG PTE+TWPG+ L N
Sbjct: 345 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGI--LSNEEF 401
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
+ + P R+ ++ + + DL +++L+ R+R+SA++A+ H +F +L ++++
Sbjct: 402 KTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 461
Query: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGHHPA 378
LPD S+F + ++L+ E +S PA
Sbjct: 462 LPDTTSIFALKEIQLQKEASLRSSSMPDSGRPA 494
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 353 bits (905), Expect = 2e-97
Identities = 180/333 (54%), Positives = 240/333 (72%), Gaps = 3/333 (0%)
Query: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
FG +Y+ L+KLGEG+YATVYKG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 159 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 218
Query: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
KHANIV LHDIIHT+++LT VFEY+ DL QY+ ++ HNV+LF+FQLLRGLAY H
Sbjct: 219 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 278
Query: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
Q VLHRDLKPQNLLI+ GELKLADFGLARAKSIP++TYS+EVVTLWYRPPD LLG+T+
Sbjct: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 338
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
YS+++D+WG GCIF EM G+PLFPG S + EQL I+ +LG PTE+TWPG+ L N
Sbjct: 339 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGI--LSNEEF 395
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
+ + P R+ ++ + + DL +++L+ R+R+SA++A+ H +F +L ++++
Sbjct: 396 KTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 455
Query: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGHHPA 378
LPD S+F + ++L+ E +S PA
Sbjct: 456 LPDTTSIFALKEIQLQKEASLRSSSMPDSGRPA 488
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 345 bits (886), Expect = 3e-95
Identities = 175/318 (55%), Positives = 227/318 (71%), Gaps = 3/318 (0%)
Query: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
FG +Y+ L+KLGEG+YATV+KG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 168 FGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNL 227
Query: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
KHANIV LHD+IHT +LT VFEY+ +DL QY+ + HNV++FMFQLLRGLAY H
Sbjct: 228 KHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCH 287
Query: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
H+ +LHRDLKPQNLLI+ GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG+TE
Sbjct: 288 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 347
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
YS+ +D+WG GCI EM G+PLFPG S + E+L I+ +LG PTE+TWPGV+ +
Sbjct: 348 YSTPIDMWGVGCIHYEMATGRPLFPG-STVKEELHLIFRLLGTPTEETWPGVTAFSEFRT 406
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
FP P+ L RL + L S +L + R+SA+ AL H YF +L +++Q
Sbjct: 407 YSFPCYLPQPLINHAPRLD--TDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQ 464
Query: 346 LPDEESLFTVSGVRLKPE 363
L D S+F++ ++L+ +
Sbjct: 465 LEDTASIFSLKEIQLQKD 482
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 345 bits (886), Expect = 3e-95
Identities = 175/318 (55%), Positives = 227/318 (71%), Gaps = 3/318 (0%)
Query: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
FG +Y+ L+KLGEG+YATV+KG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 138 FGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNL 197
Query: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
KHANIV LHD+IHT +LT VFEY+ +DL QY+ + HNV++FMFQLLRGLAY H
Sbjct: 198 KHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCH 257
Query: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
H+ +LHRDLKPQNLLI+ GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG+TE
Sbjct: 258 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 317
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
YS+ +D+WG GCI EM G+PLFPG S + E+L I+ +LG PTE+TWPGV+ +
Sbjct: 318 YSTPIDMWGVGCIHYEMATGRPLFPG-STVKEELHLIFRLLGTPTEETWPGVTAFSEFRT 376
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
FP P+ L RL + L S +L + R+SA+ AL H YF +L +++Q
Sbjct: 377 YSFPCYLPQPLINHAPRLD--TDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQ 434
Query: 346 LPDEESLFTVSGVRLKPE 363
L D S+F++ ++L+ +
Sbjct: 435 LEDTASIFSLKEIQLQKD 452
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 345 bits (886), Expect = 3e-95
Identities = 175/318 (55%), Positives = 227/318 (71%), Gaps = 3/318 (0%)
Query: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
FG +Y+ L+KLGEG+YATV+KG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 138 FGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNL 197
Query: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
KHANIV LHD+IHT +LT VFEY+ +DL QY+ + HNV++FMFQLLRGLAY H
Sbjct: 198 KHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCH 257
Query: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
H+ +LHRDLKPQNLLI+ GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG+TE
Sbjct: 258 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 317
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
YS+ +D+WG GCI EM G+PLFPG S + E+L I+ +LG PTE+TWPGV+ +
Sbjct: 318 YSTPIDMWGVGCIHYEMATGRPLFPG-STVKEELHLIFRLLGTPTEETWPGVTAFSEFRT 376
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
FP P+ L RL + L S +L + R+SA+ AL H YF +L +++Q
Sbjct: 377 YSFPCYLPQPLINHAPRLD--TDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQ 434
Query: 346 LPDEESLFTVSGVRLKPE 363
L D S+F++ ++L+ +
Sbjct: 435 LEDTASIFSLKEIQLQKD 452
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 345 bits (886), Expect = 3e-95
Identities = 176/331 (53%), Positives = 236/331 (71%), Gaps = 3/331 (0%)
Query: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
FG +Y+ LEKLGEG+YATVYKG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 186 FGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDL 245
Query: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
KHANIV LHDI+HT ++LT VFEY+ DL QYM + HNV+LF++Q+LRGLAY H
Sbjct: 246 KHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
Query: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
+ VLHRDLKPQNLLI+ GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG++E
Sbjct: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSSE 365
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
YS+++D+WG GCIF EM G+PLFPG S + ++L I+ +LG P+++TWPG+S +
Sbjct: 366 YSTQIDMWGVGCIFFEMASGRPLFPG-STVEDELHLIFRLLGTPSQETWPGISSNEEFKN 424
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
FP P+ L RL E +L ++ L+ + RVSA+EA+ H YF +L +++
Sbjct: 425 YNFPKYKPQPLINHAPRLD--SEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRIHA 482
Query: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGHH 376
LP+ S+F++ ++L+ + +SY + H
Sbjct: 483 LPESVSIFSLKEIQLQKDPGFRNSSYPETGH 513
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 286 bits (732), Expect = 2e-77
Identities = 152/289 (52%), Positives = 202/289 (69%), Gaps = 8/289 (2%)
Query: 52 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANI 110
Y LEK+GEG+Y TV+K +R ++VALK + ++ + EGVP +A+RE LLK LKH NI
Sbjct: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNI 63
Query: 111 VLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVL 170
V LHD++H+ + LT VFE+ DL +Y G L P V+ F+FQLL+GL + H ++VL
Sbjct: 64 VRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVL 123
Query: 171 HRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSEL 230
HRDLKPQNLLI+ GELKLADFGLARA IP + YS+EVVTLWYRPPD L GA YS+ +
Sbjct: 124 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSI 183
Query: 231 DIWGAGCIFIEMFQ-GQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFP 289
D+W AGCIF E+ G+PLFPG +++ +QL++I+ +LG PTE+ WP ++KLP+Y P +P
Sbjct: 184 DMWSAGCIFAELANAGRPLFPG-NDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP--YP 240
Query: 290 L-PTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFS 337
+ P SL V +L DL +LK P R+SA+EAL H YFS
Sbjct: 241 MYPATTSLVNVVPKLNAT--GRDLLQNLLKCNPVQRISAEEALQHPYFS 287
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 283 bits (725), Expect = 1e-76
Identities = 150/289 (51%), Positives = 199/289 (68%), Gaps = 6/289 (2%)
Query: 52 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANI 110
+ +EK+GEG+Y VYK +R GQLVALK I ++ E EGVP TAIRE SLLK LKH NI
Sbjct: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNI 63
Query: 111 VLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHP-HNVRLFMFQLLRGLAYIHHQHV 169
V L D++H + L VFE++ DL +YM PG P H ++ ++FQLL+G+++ H V
Sbjct: 64 VRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRV 123
Query: 170 LHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSE 229
+HRDLKPQNLLI+ LG +KLADFGLARA +P +TY+ EVVTLWYR P+ LLG+ Y++
Sbjct: 124 IHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTA 183
Query: 230 LDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFP 289
+DIW GCIF EM + LFPG S I +QL +I+ +LG P+EDTWPGV++LP+Y FP
Sbjct: 184 VDIWSIGCIFAEMVTRKALFPGDSEI-DQLFRIFRMLGTPSEDTWPGVTQLPDYKGS-FP 241
Query: 290 LPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSA 338
T + L + L PE DL Q+L+ P R++A+ AL H YFS+
Sbjct: 242 KWTRKGLEEIVPNL--EPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 288
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 262 bits (669), Expect = 4e-70
Identities = 143/288 (49%), Positives = 188/288 (65%), Gaps = 6/288 (2%)
Query: 51 SYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHAN 109
++ +EK+GEG+Y VYK +++ G++VALK I ++ E EGVP TAIRE SLLK L H N
Sbjct: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
Query: 110 IVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHP-GGLHPHNVRLFMFQLLRGLAYIHHQH 168
IV L D+IHT+ L VFE++H DL ++M G+ ++ ++FQLL+GLA+ H
Sbjct: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
Query: 169 VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS 228
VLHRDLKPQNLLI+ G +KLADFGLARA +P +TY+ EVVTLWYR P+ LLG YS+
Sbjct: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYST 182
Query: 229 ELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWF 288
+DIW GCIF EM + LFPG S I +QL +I+ LG P E WPGV+ +P+Y P F
Sbjct: 183 AVDIWSLGCIFAEMVTRRALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS-F 240
Query: 289 PLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
P + V L + L SQML P R+SA+ AL H +F
Sbjct: 241 PKWARQDFSKVVPPLDE--DGRSLLSQMLHYDPNKRISAKAALAHPFF 286
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 246 bits (629), Expect = 2e-65
Identities = 137/298 (45%), Positives = 186/298 (62%), Gaps = 7/298 (2%)
Query: 52 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEE-GVPFTAIREASLLKGLKHANI 110
Y +EK+GEG+Y VYKG + GQ+VA+K I + +EE GVP TAIRE SLLK L+H NI
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63
Query: 111 VLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHN--VRLFMFQLLRGLAYIHHQH 168
V L D++ L +FE++ DL +Y+ P G + + V+ +++Q+L+G+ + H +
Sbjct: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123
Query: 169 VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS 228
VLHRDLKPQNLLI G +KLADFGLARA IP + Y+ EVVTLWYR P+ LLG+ YS+
Sbjct: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYST 183
Query: 229 ELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWF 288
+DIW G IF E+ +PLF G S I +QL +I+ LG P + WP V L +Y F
Sbjct: 184 PVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDYK-NTF 241
Query: 289 PLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQL 346
P P SL L DL S+ML P R+S + AL H YF+ L +Q+ ++
Sbjct: 242 PKWKPGSLASHVKNLDE--NGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 244 bits (624), Expect = 7e-65
Identities = 135/298 (45%), Positives = 185/298 (62%), Gaps = 7/298 (2%)
Query: 52 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEE-GVPFTAIREASLLKGLKHANI 110
Y +EK+GEG+Y VYKG + GQ+VA+K I + +EE GVP TAIRE SLLK L+H NI
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNI 63
Query: 111 VLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHN--VRLFMFQLLRGLAYIHHQH 168
V L D++ L +FE++ DL +Y+ P G + + V+ +++Q+L+G+ + H +
Sbjct: 64 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 123
Query: 169 VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS 228
VLHRDLKPQNLLI G +KLADFGLARA IP + Y+ E +TLWYR P+ LLG+ YS+
Sbjct: 124 VLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSARYST 183
Query: 229 ELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWF 288
+DIW G IF E+ +PLF G S I +QL +I+ LG P + WP V L +Y F
Sbjct: 184 PVDIWSIGTIFAELATKKPLFHGDSEI-DQLFRIFRALGTPNNEVWPEVESLQDYK-NTF 241
Query: 289 PLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQL 346
P P SL L DL S+ML P R+S + AL H YF+ L +Q+ ++
Sbjct: 242 PKWKPGSLASHVKNLDE--NGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 213 bits (543), Expect = 2e-55
Identities = 121/304 (39%), Positives = 173/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 417 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 476
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 477 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 536
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVTLWYR P+ LLGA EYS+ +D
Sbjct: 537 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD 596
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 597 MWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEH 655
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 656 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 707
Query: 350 ESLF 353
S+F
Sbjct: 708 PSMF 711
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 213 bits (543), Expect = 2e-55
Identities = 121/304 (39%), Positives = 173/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 426 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 485
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 486 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 545
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVTLWYR P+ LLGA EYS+ +D
Sbjct: 546 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD 605
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 606 MWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEH 664
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 665 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 716
Query: 350 ESLF 353
S+F
Sbjct: 717 PSMF 720
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 213 bits (543), Expect = 2e-55
Identities = 121/304 (39%), Positives = 173/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 394 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 453
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 454 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 513
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVTLWYR P+ LLGA EYS+ +D
Sbjct: 514 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD 573
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 574 MWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEH 632
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 633 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 684
Query: 350 ESLF 353
S+F
Sbjct: 685 PSMF 688
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 213 bits (543), Expect = 2e-55
Identities = 121/304 (39%), Positives = 173/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 383 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 442
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 443 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 502
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVTLWYR P+ LLGA EYS+ +D
Sbjct: 503 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD 562
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 563 MWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEH 621
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 622 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 673
Query: 350 ESLF 353
S+F
Sbjct: 674 PSMF 677
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 213 bits (543), Expect = 2e-55
Identities = 121/304 (39%), Positives = 173/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 172 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 231
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 232 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 291
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVTLWYR P+ LLGA EYS+ +D
Sbjct: 292 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD 351
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 352 MWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEH 410
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 411 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 462
Query: 350 ESLF 353
S+F
Sbjct: 463 PSMF 466
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 213 bits (543), Expect = 2e-55
Identities = 121/304 (39%), Positives = 173/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 428 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 487
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 488 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 547
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVTLWYR P+ LLGA EYS+ +D
Sbjct: 548 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVD 607
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 608 MWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEH 666
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 667 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 718
Query: 350 ESLF 353
S+F
Sbjct: 719 PSMF 722
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 211 bits (538), Expect = 7e-55
Identities = 121/298 (40%), Positives = 174/298 (58%), Gaps = 13/298 (4%)
Query: 49 ASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMN----AEEGVPFTAIREASLLKG 104
A Y L+ LGEG +ATVYK + Q+VA+K I + A++G+ TA+RE LL+
Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68
Query: 105 LKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYI 164
L H NI+ L D K ++ VF++M TDL + + L P +++ +M L+GL Y+
Sbjct: 69 LSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYL 128
Query: 165 HHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGAT 224
H +LHRDLKP NLL+ G LKLADFGLA++ P++ Y+ +VVT WYR P+ L GA
Sbjct: 129 HQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGAR 188
Query: 225 EYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNY- 283
Y +D+W GCI E+ P PG S+ L+QL +I+E LG PTE+ WP + LP+Y
Sbjct: 189 MYGVGVDMWAVGCILAELLLRVPFLPGDSD-LDQLTRIFETLGTPTEEQWPDMCSLPDYV 247
Query: 284 NPEWFP-LPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALP 340
+ FP +P LH +++ G + DL + P R++A +AL YFS P
Sbjct: 248 TFKSFPGIP----LHHIFSAAG--DDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 211 bits (536), Expect = 1e-54
Identities = 120/304 (39%), Positives = 172/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 416 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 475
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 476 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 535
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVT WYR P+ LLGA EYS+ +D
Sbjct: 536 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVD 595
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 596 MWSVGCIFGELLTQKPLFPGNSEI-DQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEH 654
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 655 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 706
Query: 350 ESLF 353
S+F
Sbjct: 707 PSMF 710
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 211 bits (536), Expect = 1e-54
Identities = 120/304 (39%), Positives = 172/304 (56%), Gaps = 14/304 (4%)
Query: 55 LEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHANIVLL 113
L ++ EG+Y VY+ + ++VALK + M E EG P T++RE + + +H NIV +
Sbjct: 426 LNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTV 485
Query: 114 HDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLH 171
+I+ + + V Y+ DL M P V+ M QLLRG+ ++H +LH
Sbjct: 486 REIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILH 545
Query: 172 RDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELD 231
RDLK NLL+SH G LK+ DFGLAR P + Y+ VVT WYR P+ LLGA EYS+ +D
Sbjct: 546 RDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAKEYSTAVD 605
Query: 232 IWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLP 291
+W GCIF E+ +PLFPG S I +Q+ K+++ LG P+E WPG S+LP F
Sbjct: 606 MWSVGCIFGELLTQKPLFPGNSEI-DQINKVFKELGTPSEKIWPGYSELPVVKKMTFSEH 664
Query: 292 TPRSLHVVWNRLGRV--PEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE 349
+L R G + + DL ++ L FP R+SA++ L H+YF P LP +
Sbjct: 665 PYNNLR---KRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP-----LPID 716
Query: 350 ESLF 353
S+F
Sbjct: 717 PSMF 720
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 199 bits (507), Expect = 3e-51
Identities = 122/288 (42%), Positives = 164/288 (56%), Gaps = 40/288 (13%)
Query: 51 SYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLKHAN 109
++ +EK+GEG+Y VYK +++ G++VALK I ++ E EGVP TAIRE SLLK L H N
Sbjct: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPN 62
Query: 110 IVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHP-GGLHPHNVRLFMFQLLRGLAYIHHQH 168
IV L D+IHT+ L VFE++H DL ++M G+ ++ ++FQLL+GLA+ H
Sbjct: 63 IVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHR 122
Query: 169 VLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSS 228
VLHRDLKPQNLLI+ G +KLADFGLARA +P +TY+ EV
Sbjct: 123 VLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVTR----------------- 165
Query: 229 ELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWF 288
+ LFPG S I +QL +I+ LG P E WPGV+ +P+Y P F
Sbjct: 166 -----------------RALFPGDSEI-DQLFRIFRTLGTPDEVVWPGVTSMPDYKPS-F 206
Query: 289 PLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
P + V L + L SQML P R+SA+ AL H +F
Sbjct: 207 PKWARQDFSKVVPPLDE--DGRSLLSQMLHYDPNKRISAKAALAHPFF 252
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 197 bits (500), Expect = 2e-50
Identities = 116/306 (37%), Positives = 174/306 (56%), Gaps = 8/306 (2%)
Query: 52 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMNA-EEGVPFTAIREASLLKGLK-HAN 109
Y L ++GEG++ V+K G++VALK +++ E+G P A+RE L+ ++ +
Sbjct: 4 YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQY 63
Query: 110 IVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHV 169
+V L + FE+M +DLA+ + L V+ ++ LL+G+A+ H ++
Sbjct: 64 VVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNI 123
Query: 170 LHRDLKPQNLLISHLGELKLADFGLARAKSIP-SQTYSSEVVTLWYRPPDALLGATEYSS 228
+HRDLKP NLLIS G+LK+ADFGLAR S S+ Y+ +V T WYR P+ L GA +Y
Sbjct: 124 VHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQ 183
Query: 229 ELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWF 288
+D+W GCI E+ G PLFPG N +EQL + +LG P WP +++LP+YN F
Sbjct: 184 GVDLWSVGCIMGELLNGSPLFPG-KNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISF 242
Query: 289 PLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF--SALPSQLYQL 346
P L V + P+A DL Q L P R++A +AL+H YF + LP+ +L
Sbjct: 243 KEQVPMPLEEVLPDVS--PQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSEL 300
Query: 347 PDEESL 352
P + L
Sbjct: 301 PIPQRL 306
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 195 bits (495), Expect = 7e-50
Identities = 121/303 (39%), Positives = 177/303 (58%), Gaps = 19/303 (6%)
Query: 48 AASSYLNLEKLGEGSYATVYKGISRING-QLVALKVISMNA-EEGVPFTAIREASLLKGL 105
A Y + ++GEG+Y V+K NG + VALK + + EEG+P + IRE ++L+ L
Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68
Query: 106 K---HANIVLLHDIIHTKET-----LTFVFEYMHTDLAQYMSQHPG-GLHPHNVRLFMFQ 156
+ H N+V L D+ T LT VFE++ DL Y+ + P G+ ++ MFQ
Sbjct: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128
Query: 157 LLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRP 216
LLRGL ++H V+HRDLKPQN+L++ G++KLADFGLAR S +S VVTLWYR
Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRA 187
Query: 217 PDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPG 276
P+ LL + Y++ +D+W GCIF EMF+ +PLF G S++ +QL KI +V+G+P E+ WP
Sbjct: 188 PEVLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPR 245
Query: 277 VSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
LP + F + + + + + +DL + L P R+SA AL H YF
Sbjct: 246 DVALPR---QAFHSKSAQPIEKFVTDIDEL--GKDLLLKCLTFNPAKRISAYSALSHPYF 300
Query: 337 SAL 339
L
Sbjct: 301 QDL 303
>gi|4502741 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 195 bits (495), Expect = 7e-50
Identities = 121/303 (39%), Positives = 177/303 (58%), Gaps = 19/303 (6%)
Query: 48 AASSYLNLEKLGEGSYATVYKGISRING-QLVALKVISMNA-EEGVPFTAIREASLLKGL 105
A Y + ++GEG+Y V+K NG + VALK + + EEG+P + IRE ++L+ L
Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHL 68
Query: 106 K---HANIVLLHDIIHTKET-----LTFVFEYMHTDLAQYMSQHPG-GLHPHNVRLFMFQ 156
+ H N+V L D+ T LT VFE++ DL Y+ + P G+ ++ MFQ
Sbjct: 69 ETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQ 128
Query: 157 LLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRP 216
LLRGL ++H V+HRDLKPQN+L++ G++KLADFGLAR S +S VVTLWYR
Sbjct: 129 LLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRA 187
Query: 217 PDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPG 276
P+ LL + Y++ +D+W GCIF EMF+ +PLF G S++ +QL KI +V+G+P E+ WP
Sbjct: 188 PEVLL-QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDV-DQLGKILDVIGLPGEEDWPR 245
Query: 277 VSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
LP + F + + + + + +DL + L P R+SA AL H YF
Sbjct: 246 DVALPR---QAFHSKSAQPIEKFVTDIDEL--GKDLLLKCLTFNPAKRISAYSALSHPYF 300
Query: 337 SAL 339
L
Sbjct: 301 QDL 303
>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
Length = 372
Score = 192 bits (487), Expect = 6e-49
Identities = 120/309 (38%), Positives = 165/309 (53%), Gaps = 16/309 (5%)
Query: 50 SSYLNLEKLGEGSYATVYKGISRINGQLVALKVISM-NAEEGVPFTAIREASLLKGLKHA 108
S Y L K+G+G++ V+K R GQ VALK + M N +EG P TA+RE +L+ LKH
Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE 76
Query: 109 NIVLLHDIIHTKET--------LTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRG 160
N+V L +I TK + + VF++ DLA +S ++ M LL G
Sbjct: 77 NVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNG 136
Query: 161 LAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQT----YSSEVVTLWYRP 216
L YIH +LHRD+K N+LI+ G LKLADFGLARA S+ + Y++ VVTLWYRP
Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196
Query: 217 PDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPG 276
P+ LLG +Y +D+WGAGCI EM+ P+ G + QL I ++ G T + WP
Sbjct: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQG-NTEQHQLALISQLCGSITPEVWPN 255
Query: 277 VSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYF 336
V Y R + R P A DL ++L P R+ + +AL HD+F
Sbjct: 256 VDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315
Query: 337 --SALPSQL 343
+PS L
Sbjct: 316 WSDPMPSDL 324
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 191 bits (485), Expect = 9e-49
Identities = 96/237 (40%), Positives = 146/237 (61%), Gaps = 4/237 (1%)
Query: 48 AASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAE-EGVPFTAIREASLLKGLK 106
+ + L ++GEG+Y VY+ ++VALK + M+ E +G+P +++RE +LL L+
Sbjct: 35 SVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR 94
Query: 107 HANIVLLHDII--HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYI 164
H NIV L +++ + E++ V Y DLA + P V+ + Q+LRGL Y+
Sbjct: 95 HPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYL 154
Query: 165 HHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGAT 224
H ++HRDLK NLL++ G +K ADFGLARA +P + + +VVTLWYR P+ LLG T
Sbjct: 155 HRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTT 214
Query: 225 EYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLP 281
++ +D+W GCI E+ +PL PG S I Q++ I ++LG P+E+ WPG SKLP
Sbjct: 215 TQTTSIDMWAVGCILAELLAHRPLLPGTSEI-HQIDLIVQLLGTPSENIWPGFSKLP 270
>gi|4502735 cyclin-dependent kinase 4 [Homo sapiens]
Length = 303
Score = 191 bits (484), Expect = 1e-48
Identities = 123/305 (40%), Positives = 173/305 (56%), Gaps = 29/305 (9%)
Query: 48 AASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISM----NAEEGVPFTAIREASLLK 103
A S Y + ++G G+Y TVYK +G VALK + + G+P + +RE +LL+
Sbjct: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61
Query: 104 GLK---HANIVLLHDIIHTKET-----LTFVFEYMHTDLAQYMSQHPG-GLHPHNVRLFM 154
L+ H N+V L D+ T T +T VFE++ DL Y+ + P GL ++ M
Sbjct: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121
Query: 155 FQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWY 214
Q LRGL ++H ++HRDLKP+N+L++ G +KLADFGLAR S + VVTLWY
Sbjct: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWY 180
Query: 215 RPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTW 274
R P+ LL +T Y++ +D+W GCIF EMF+ +PLF G S +QL KI++++G+P ED W
Sbjct: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSE-ADQLGKIFDLIGLPPEDDW 238
Query: 275 PGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQ----MLKGFPRDRVSAQEA 330
P LP FP PR + V VPE E+ +Q ML P R+SA A
Sbjct: 239 PRDVSLPR---GAFPPRGPRPVQSV------VPEMEESGAQLLLEMLTFNPHKRISAFRA 289
Query: 331 LVHDY 335
L H Y
Sbjct: 290 LQHSY 294
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 187 bits (475), Expect = 1e-47
Identities = 112/304 (36%), Positives = 167/304 (54%), Gaps = 17/304 (5%)
Query: 58 LGEGSYATVYKGISRINGQLVALKVISM-NAEEGVPFTAIREASLLKGLKHANIVLLHDI 116
+GEG+Y VYK + G++VALK + + N +EG P TAIRE +L+ L H +I+ + +I
Sbjct: 711 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 770
Query: 117 IHTKE----------TLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHH 166
+ KE VFEYM DL + + ++++ FM QL+ GL Y H
Sbjct: 771 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHK 830
Query: 167 QHVLHRDLKPQNLLISHLGELKLADFGLARA-KSIPSQTYSSEVVTLWYRPPDALLGATE 225
++ LHRD+K N+L+++ G++KLADFGLAR S S+ Y+++V+TLWYRPP+ LLG
Sbjct: 831 KNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEER 890
Query: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
Y+ +D+W GCI E+F +P+F + L QLE I + G P WP V KLP +N
Sbjct: 891 YTPAIDVWSCGCILGELFTKKPIFQ-ANQELAQLELISRICGSPCPAVWPDVIKLPYFNT 949
Query: 286 EWFPLPTPRSLHVVWNRLGRVPEAE-DLASQMLKGFPRDRVSAQEALVHDYFSALPSQLY 344
P + + +P A DL ML P R +A++AL ++ +
Sbjct: 950 ---MKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKM 1006
Query: 345 QLPD 348
PD
Sbjct: 1007 PPPD 1010
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,381,340
Number of Sequences: 37866
Number of extensions: 717730
Number of successful extensions: 3786
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 723
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 1622
Number of HSP's gapped (non-prelim): 926
length of query: 384
length of database: 18,247,518
effective HSP length: 104
effective length of query: 280
effective length of database: 14,309,454
effective search space: 4006647120
effective search space used: 4006647120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.