Search of human proteins with 209862748

Search of human proteins with 209862748

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209862748 ataxin 3-like [Homo sapiens]
         (355 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209862748 ataxin 3-like [Homo sapiens]                             715   0.0  
gi|13518019 ataxin 3 isoform 1 [Homo sapiens]                         483   e-136
gi|189163493 ataxin 3 isoform 3 [Homo sapiens]                        446   e-125
gi|13518013 ataxin 3 isoform 2 [Homo sapiens]                         370   e-102
gi|189163495 ataxin 3 isoform 4 [Homo sapiens]                        253   2e-67
gi|19923879 Josephin domain containing 2 [Homo sapiens]                52   1e-06
gi|7661888 Josephin domain containing 1 [Homo sapiens]                 47   3e-05
gi|67551265 transcription factor ELYS [Homo sapiens]                   43   5e-04
gi|104526627 triadin [Homo sapiens]                                    40   0.002
gi|153792780 additional sex combs like 2 [Homo sapiens]                40   0.002
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo...    39   0.005
gi|55741677 SET domain containing 1A [Homo sapiens]                    39   0.007
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    39   0.009
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    39   0.009
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi...    38   0.012
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]    38   0.012
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    38   0.012
gi|27597090 suppressor of Ty 6 homolog [Homo sapiens]                  38   0.012
gi|19923844 coiled-coil domain containing 82 [Homo sapiens]            37   0.021
gi|148746195 trichohyalin [Homo sapiens]                               37   0.027
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]      37   0.027
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      37   0.027
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      37   0.027
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       37   0.027
gi|33286444 mastermind-like 2 [Homo sapiens]                           37   0.035
gi|27734775 hypothetical protein LOC286499 [Homo sapiens]              37   0.035
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho...    36   0.060
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    35   0.078
gi|34101288 cleavage and polyadenylation specific factor 2 [Homo...    35   0.13 
gi|210032580 SET domain containing 1B [Homo sapiens]                   35   0.13 

>gi|209862748 ataxin 3-like [Homo sapiens]
          Length = 355

 Score =  715 bits (1846), Expect = 0.0
 Identities = 355/355 (100%), Positives = 355/355 (100%)

Query: 1   MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLA 60
           MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLA
Sbjct: 1   MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLA 60

Query: 61  FLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHW 120
           FLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHW
Sbjct: 61  FLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHW 120

Query: 121 FTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQI 180
           FTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQI
Sbjct: 121 FTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQI 180

Query: 181 ISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQET 240
           ISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQET
Sbjct: 181 ISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQET 240

Query: 241 NREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQ 300
           NREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQ
Sbjct: 241 NREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQ 300

Query: 301 SDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTILEIMRKNLKIKGEK 355
           SDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTILEIMRKNLKIKGEK
Sbjct: 301 SDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTILEIMRKNLKIKGEK 355


>gi|13518019 ataxin 3 isoform 1 [Homo sapiens]
          Length = 361

 Score =  483 bits (1243), Expect = e-136
 Identities = 252/361 (69%), Positives = 291/361 (80%), Gaps = 6/361 (1%)

Query: 1   MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLA 60
           M+ IFHEKQEG LCAQHCLNNLLQGEYFSPVEL+SIAHQLDEEERMRMAEGGVTSE+Y  
Sbjct: 1   MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRT 60

Query: 61  FLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHW 120
           FLQQPS NMDD+GFFSIQVISNALK WGLE+I FN+PEYQ+L IDPINERSFICNYK+HW
Sbjct: 61  FLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHW 120

Query: 121 FTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQI 180
           FT+RK GK WFNLNSLL GPELISDT LA FLA+LQQ+ YS+FVVKGDLPDCEADQLLQ+
Sbjct: 121 FTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQM 180

Query: 181 ISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQET 240
           I V++M  PKL G++L + KE RV+KT LE+V E +D SG  D+DEED QRAL LSRQE 
Sbjct: 181 IRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEI 240

Query: 241 NREDEH--LRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKH---QQEQK 295
           + EDE   LR  I+LSMQGSS N SQD+ +TS     SE+ +K +E YFEK    QQ+Q+
Sbjct: 241 DMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQ 300

Query: 296 QQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDIS-EGTVQAAVDTILEIMRKNLKIKGE 354
           QQQQQ DL G SS+  ERP TSS A+ SDL D +S E  +QAAV   LE +R +LK +G+
Sbjct: 301 QQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGK 360

Query: 355 K 355
           K
Sbjct: 361 K 361


>gi|189163493 ataxin 3 isoform 3 [Homo sapiens]
          Length = 346

 Score =  446 bits (1148), Expect = e-125
 Identities = 239/361 (66%), Positives = 277/361 (76%), Gaps = 21/361 (5%)

Query: 1   MDFIFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLA 60
           M+ IFHEKQEG LCAQHCLNNLLQGEYFSPVEL+SIAHQLDEEERMRMAEGGVTSE+Y  
Sbjct: 1   MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRT 60

Query: 61  FLQQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHW 120
           FLQ               VISNALK WGLE+I FN+PEYQ+L IDPINERSFICNYK+HW
Sbjct: 61  FLQ---------------VISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHW 105

Query: 121 FTIRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQI 180
           FT+RK GK WFNLNSLL GPELISDT LA FLA+LQQ+ YS+FVVKGDLPDCEADQLLQ+
Sbjct: 106 FTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQM 165

Query: 181 ISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQET 240
           I V++M  PKL G++L + KE RV+KT LE+V E +D SG  D+DEED QRAL LSRQE 
Sbjct: 166 IRVQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEI 225

Query: 241 NREDEH--LRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKH---QQEQK 295
           + EDE   LR  I+LSMQGSS N SQD+ +TS     SE+ +K +E YFEK    QQ+Q+
Sbjct: 226 DMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQ 285

Query: 296 QQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDIS-EGTVQAAVDTILEIMRKNLKIKGE 354
           QQQQQ DL G SS+  ERP TSS A+ SDL D +S E  +QAAV   LE +R +LK +G+
Sbjct: 286 QQQQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGK 345

Query: 355 K 355
           K
Sbjct: 346 K 346


>gi|13518013 ataxin 3 isoform 2 [Homo sapiens]
          Length = 306

 Score =  370 bits (949), Expect = e-102
 Identities = 196/299 (65%), Positives = 233/299 (77%), Gaps = 6/299 (2%)

Query: 63  QQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPINERSFICNYKQHWFT 122
           +QPS NMDD+GFFSIQVISNALK WGLE+I FN+PEYQ+L IDPINERSFICNYK+HWFT
Sbjct: 8   KQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRLRIDPINERSFICNYKEHWFT 67

Query: 123 IRKFGKHWFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIIS 182
           +RK GK WFNLNSLL GPELISDT LA FLA+LQQ+ YS+FVVKGDLPDCEADQLLQ+I 
Sbjct: 68  VRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIR 127

Query: 183 VEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNR 242
           V++M  PKL G++L + KE RV+KT LE+V E +D SG  D+DEED QRAL LSRQE + 
Sbjct: 128 VQQMHRPKLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDM 187

Query: 243 EDEH--LRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKH---QQEQKQQ 297
           EDE   LR  I+LSMQGSS N SQD+ +TS     SE+ +K +E YFEK    QQ+Q+QQ
Sbjct: 188 EDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQ 247

Query: 298 QQQSDLPGHSSYLHERPTTSSRAIESDLSDDIS-EGTVQAAVDTILEIMRKNLKIKGEK 355
           QQQ DL G SS+  ERP TSS A+ SDL D +S E  +QAAV   LE +R +LK +G+K
Sbjct: 248 QQQGDLSGQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK 306


>gi|189163495 ataxin 3 isoform 4 [Homo sapiens]
          Length = 295

 Score =  253 bits (645), Expect = 2e-67
 Identities = 142/232 (61%), Positives = 172/232 (74%), Gaps = 6/232 (2%)

Query: 130 WFNLNSLLAGPELISDTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTP 189
           WFNLNSLL GPELISDT LA FLA+LQQ+ YS+FVVKGDLPDCEADQLLQ+I V++M  P
Sbjct: 64  WFNLNSLLTGPELISDTYLALFLAQLQQEGYSIFVVKGDLPDCEADQLLQMIRVQQMHRP 123

Query: 190 KLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEH--L 247
           KL G++L + KE RV+KT LE+V E +D SG  D+DEED QRAL LSRQE + EDE   L
Sbjct: 124 KLIGEELAQLKEQRVHKTDLERVLEANDGSGMLDEDEEDLQRALALSRQEIDMEDEEADL 183

Query: 248 RSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKH---QQEQKQQQQQSDLP 304
           R  I+LSMQGSS N SQD+ +TS     SE+ +K +E YFEK    QQ+Q+QQQQQ DL 
Sbjct: 184 RRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRREAYFEKQQQKQQQQQQQQQQGDLS 243

Query: 305 GHSSYLHERPTTSSRAIESDLSDDIS-EGTVQAAVDTILEIMRKNLKIKGEK 355
           G SS+  ERP TSS A+ SDL D +S E  +QAAV   LE +R +LK +G+K
Sbjct: 244 GQSSHPCERPATSSGALGSDLGDAMSEEDMLQAAVTMSLETVRNDLKTEGKK 295


>gi|19923879 Josephin domain containing 2 [Homo sapiens]
          Length = 188

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 41/161 (25%), Positives = 66/161 (40%), Gaps = 42/161 (26%)

Query: 4   IFHEKQEGFLCAQHCLNNLLQGEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLAFLQ 63
           ++HE+Q   LCA H LNN+LQ + FS      I  +L  + R+                 
Sbjct: 14  VYHERQRLELCAVHALNNVLQQQLFSQEAADEICKRLAPDSRL----------------- 56

Query: 64  QPSENMDDTGFFSIQVISNALKFWGLEIIHF-------------------NNPEYQKLGI 104
            P  ++  TG + + VI  AL+  GL  + +                   N P    LG+
Sbjct: 57  NPHRSLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLILNLPSPVSLGL 116

Query: 105 DPINERSFICNYKQHWFTIRKFGKHWFNLNSLLAGPELISD 145
             +  R      ++HW  +R+    ++NL+S L  PE + D
Sbjct: 117 LSLPLR------RRHWVALRQVDGVYYNLDSKLRAPEALGD 151


>gi|7661888 Josephin domain containing 1 [Homo sapiens]
          Length = 202

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 42/156 (26%), Positives = 66/156 (42%), Gaps = 34/156 (21%)

Query: 4   IFHEKQEGFLCAQHCLNNLLQ-GEYFSPVELASIAHQLDEEERMRMAEGGVTSEEYLAFL 62
           I+HEKQ   LCA H LNN+ Q    F+   L  I  +L                     +
Sbjct: 26  IYHEKQRRELCALHALNNVFQDSNAFTRDTLQEIFQRLSPN----------------TMV 69

Query: 63  QQPSENMDDTGFFSIQVISNALKFWGLEIIHFNNPEYQKLGIDPI-NERSFICNY----- 116
               ++M   G + + VI  AL+  G E + ++  + + +G+  + N   FI N      
Sbjct: 70  TPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWD--KRRDVGVIALTNVMGFIMNLPSSLC 127

Query: 117 ---------KQHWFTIRKFGKHWFNLNSLLAGPELI 143
                    +QHW  +R+ G  ++NL+S L  PE I
Sbjct: 128 WGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWI 163


>gi|67551265 transcription factor ELYS [Homo sapiens]
          Length = 2266

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 41/162 (25%), Positives = 66/162 (40%), Gaps = 28/162 (17%)

Query: 180  IISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQE 239
            ++  EE+     + KKL K+ E +  K  L  VSEE               R  E++ +E
Sbjct: 2032 LVPNEELSMVMSSKKKLTKKTESQSQKRSLHSVSEE---------------RTDEMTHKE 2076

Query: 240  TNREDEHLRSTIELSMQGSSGNTSQD----LPKTS------CVTPASEQPKKIKEDYFEK 289
            TN ++E L +T   +    S  T       LP  S        +PASE P+K K    E 
Sbjct: 2077 TNEQEERLLATASFTKSSRSSRTRSSKAILLPDLSEPNNEPLFSPASEVPRKAKAKKIEV 2136

Query: 290  HQQEQK---QQQQQSDLPGHSSYLHERPTTSSRAIESDLSDD 328
              Q ++       Q  +   +    ++ T++   +E +L DD
Sbjct: 2137 PAQLKELVSDLSSQFVISPPALRSRQKNTSNKNKLEDELKDD 2178


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 29/142 (20%), Positives = 67/142 (47%), Gaps = 4/142 (2%)

Query: 165 VKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSD- 223
           V GDL   ++  +   +  E+   P      L +++  +  K   +KV+ E+ +    D 
Sbjct: 278 VHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEK--KKAEKKVTSETKKKEKEDI 335

Query: 224 QDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPAS-EQPKKI 282
           + + + + A+++ ++E  +  E  + T++++ Q ++    +         PA  EQPK  
Sbjct: 336 KKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGK 395

Query: 283 KEDYFEKHQQEQKQQQQQSDLP 304
           K++  EKH +  K  +++  +P
Sbjct: 396 KQEKKEKHVEPAKSPKKEHSVP 417


>gi|153792780 additional sex combs like 2 [Homo sapiens]
          Length = 1435

 Score = 40.4 bits (93), Expect = 0.002
 Identities = 32/116 (27%), Positives = 54/116 (46%), Gaps = 2/116 (1%)

Query: 209 LEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQG-SSGNTSQDLP 267
           ++++SE S+ES     D +  + +   S   +N+E +  R   ++S     SG  S  +P
Sbjct: 91  VKELSEGSEESSDGQSDSQSSENSSSSSDGGSNKEGKKSRWKRKVSSSSPQSGCPSPTIP 150

Query: 268 KTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIES 323
               ++P+ +  KK  +    K QQ++KQQQQ       SS  H    T   A +S
Sbjct: 151 AGKVISPSQKHSKKALKQAL-KQQQQKKQQQQCRPSISISSNQHLSLKTVKAASDS 205


>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
           [Homo sapiens]
          Length = 666

 Score = 39.3 bits (90), Expect = 0.005
 Identities = 35/146 (23%), Positives = 63/146 (43%), Gaps = 10/146 (6%)

Query: 210 EKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKT 269
           E  S++SD+    + D+E+  +  +  + + + +DE +++T +      S +  Q L + 
Sbjct: 148 EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE 207

Query: 270 SCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDI 329
                  E+P     D  EK   + ++Q Q SD     +   ERP  S    E   SDD 
Sbjct: 208 EKANSDDERPVASDND-DEKQNSDDEEQPQLSDEEKMQNSDDERPQASDE--EHRHSDDE 264

Query: 330 SEGTVQA-------AVDTILEIMRKN 348
            E   ++       + D +L + RKN
Sbjct: 265 EEQDHKSESARGSDSEDEVLRMKRKN 290



 Score = 28.9 bits (63), Expect = 7.3
 Identities = 27/129 (20%), Positives = 52/129 (40%), Gaps = 10/129 (7%)

Query: 201 EHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSG 260
           E R   +  +K+    D+    + D+E+  +  +  RQ+ + E+E   S  E  +   + 
Sbjct: 165 EERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLS-EEEKANSDDERPVASDND 223

Query: 261 NTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRA 320
           +  Q+       +   EQP+   E+  +    E+ Q   +     HS    E+   S  A
Sbjct: 224 DEKQN-------SDDEEQPQLSDEEKMQNSDDERPQASDEEH--RHSDDEEEQDHKSESA 274

Query: 321 IESDLSDDI 329
             SD  D++
Sbjct: 275 RGSDSEDEV 283


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 26/135 (19%), Positives = 62/135 (45%), Gaps = 10/135 (7%)

Query: 210  EKVSEESDESGTSDQDEEDFQRALELSRQET---NREDEHLRSTIELSM-------QGSS 259
            E  SE+ +E    D+++ED + A++ +++ET   + EDE   S+ + S+         S+
Sbjct: 971  ESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDST 1030

Query: 260  GNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSR 319
             ++      +S  + +S           E   ++++++++ + LP  S    E P  +  
Sbjct: 1031 SDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPA 1090

Query: 320  AIESDLSDDISEGTV 334
             +E  + + ++   V
Sbjct: 1091 PVEVPVPERVAGSPV 1105


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 27/125 (21%)

Query: 194  KKLVKQKEHRVYK-----TVLEKVSEESD--ESGTSDQ--DEEDFQRA-------LELSR 237
            +K  K KEH+  K      V  + SE+SD  ESG S++  + ED QR         EL  
Sbjct: 1317 EKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEE 1376

Query: 238  QETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQ 297
             + + + +  R  I++    SS N S            SE+ ++ KE+  E+ ++E++++
Sbjct: 1377 NQRSYKQKKKRRRIKVQEDSSSENKSN-----------SEEEEEEKEEEEEEEEEEEEEE 1425

Query: 298  QQQSD 302
            + ++D
Sbjct: 1426 EDEND 1430



 Score = 32.0 bits (71), Expect = 0.87
 Identities = 33/132 (25%), Positives = 57/132 (43%), Gaps = 11/132 (8%)

Query: 209 LEK--VSEESDESGTSDQDEEDFQRALELSRQETNRED--EHLRSTIELSMQGSSGNTSQ 264
           LEK  +S+   +      D E   + +    Q TN+    EH +S  +   Q    NTS+
Sbjct: 414 LEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSE 473

Query: 265 DLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESD 324
           DL       P+S     + ED FE + +   + Q   D  G  S   E+   SS +++ +
Sbjct: 474 DLDMDIVSVPSS-----VPEDIFE-NLETAMEVQSSVDHQGDGSSGTEQEVESS-SVKLN 526

Query: 325 LSDDISEGTVQA 336
           +S   + G +++
Sbjct: 527 ISSKDNRGGIKS 538



 Score = 30.4 bits (67), Expect = 2.5
 Identities = 31/153 (20%), Positives = 66/153 (43%), Gaps = 10/153 (6%)

Query: 181  ISVEEMDTPKLNGKKLVKQKE---HRVYKTV------LEKVSEESDESGTSDQDEEDFQR 231
            +S +E     L  +K+ + KE   H   KT       L  ++E+  +   SD+  ED ++
Sbjct: 886  LSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKK 945

Query: 232  ALELSRQETNREDEHLRSTIELSMQ-GSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKH 290
              +   +E  +  +  +  I++  Q  SS + ++ LP+   +    +  K+IK    +  
Sbjct: 946  QSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE 1005

Query: 291  QQEQKQQQQQSDLPGHSSYLHERPTTSSRAIES 323
            ++ +K + + S      S   E+ T    + +S
Sbjct: 1006 KKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1038


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 34/125 (27%), Positives = 61/125 (48%), Gaps = 27/125 (21%)

Query: 194  KKLVKQKEHRVYK-----TVLEKVSEESD--ESGTSDQ--DEEDFQRA-------LELSR 237
            +K  K KEH+  K      V  + SE+SD  ESG S++  + ED QR         EL  
Sbjct: 1355 EKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEE 1414

Query: 238  QETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQ 297
             + + + +  R  I++    SS N S            SE+ ++ KE+  E+ ++E++++
Sbjct: 1415 NQRSYKQKKKRRRIKVQEDSSSENKSN-----------SEEEEEEKEEEEEEEEEEEEEE 1463

Query: 298  QQQSD 302
            + ++D
Sbjct: 1464 EDEND 1468



 Score = 32.0 bits (71), Expect = 0.87
 Identities = 33/132 (25%), Positives = 57/132 (43%), Gaps = 11/132 (8%)

Query: 209 LEK--VSEESDESGTSDQDEEDFQRALELSRQETNRED--EHLRSTIELSMQGSSGNTSQ 264
           LEK  +S+   +      D E   + +    Q TN+    EH +S  +   Q    NTS+
Sbjct: 452 LEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSE 511

Query: 265 DLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESD 324
           DL       P+S     + ED FE + +   + Q   D  G  S   E+   SS +++ +
Sbjct: 512 DLDMDIVSVPSS-----VPEDIFE-NLETAMEVQSSVDHQGDGSSGTEQEVESS-SVKLN 564

Query: 325 LSDDISEGTVQA 336
           +S   + G +++
Sbjct: 565 ISSKDNRGGIKS 576



 Score = 30.4 bits (67), Expect = 2.5
 Identities = 31/153 (20%), Positives = 66/153 (43%), Gaps = 10/153 (6%)

Query: 181  ISVEEMDTPKLNGKKLVKQKE---HRVYKTV------LEKVSEESDESGTSDQDEEDFQR 231
            +S +E     L  +K+ + KE   H   KT       L  ++E+  +   SD+  ED ++
Sbjct: 924  LSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKK 983

Query: 232  ALELSRQETNREDEHLRSTIELSMQ-GSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKH 290
              +   +E  +  +  +  I++  Q  SS + ++ LP+   +    +  K+IK    +  
Sbjct: 984  QSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGE 1043

Query: 291  QQEQKQQQQQSDLPGHSSYLHERPTTSSRAIES 323
            ++ +K + + S      S   E+ T    + +S
Sbjct: 1044 KKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1076


>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
          Length = 1790

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 36/174 (20%), Positives = 72/174 (41%), Gaps = 8/174 (4%)

Query: 166  KGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQD 225
            K  + D E ++  + +  E+ D       KL   +E     TV  +    SD +  S+++
Sbjct: 1564 KRGIVDLEGEEWQRRLEEEDKDY-----LKLTLDQEEATESTVESEEESSSDYTEYSEEE 1618

Query: 226  EE--DFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIK 283
             E  + +   E S  ET  E+E   ST E     S+ +  +   K   +       +++K
Sbjct: 1619 SEFSESETTEEESESETPSEEEE-SSTPESEESESTESEGEKARKNIVLARRRPMVEEVK 1677

Query: 284  EDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAA 337
            E    K + +++Q++ + +   HS      P     + + +  D   EG+ ++A
Sbjct: 1678 EVKGRKEEPQEEQKEPKMEEEEHSEEEESGPAPVEESTDPEAQDIPEEGSAESA 1731



 Score = 35.0 bits (79), Expect = 0.10
 Identities = 28/129 (21%), Positives = 54/129 (41%), Gaps = 22/129 (17%)

Query: 200  KEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQE----TNREDEHLRSTIELSM 255
            K  R++  + +KV   +D+ G  D + E++QR LE   ++    T  ++E   ST+E   
Sbjct: 1546 KRARIFPMIFKKVRGLADKRGIVDLEGEEWQRRLEEEDKDYLKLTLDQEEATESTVESEE 1605

Query: 256  QGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPT 315
            + SS  T                  +  E+  E  + E  +++ +S+ P          +
Sbjct: 1606 ESSSDYT------------------EYSEEESEFSESETTEEESESETPSEEEESSTPES 1647

Query: 316  TSSRAIESD 324
              S + ES+
Sbjct: 1648 EESESTESE 1656


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 44/199 (22%), Positives = 87/199 (43%), Gaps = 36/199 (18%)

Query: 148 LANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLN-GKKLVKQKEHRVYK 206
           LA    RLQQQA  + +    +   +A Q+ Q ++++++++ K    ++L + +E R + 
Sbjct: 245 LAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFL 304

Query: 207 TVLEKVSEESDESGTSDQDEEDFQRALELSRQET----------NREDEHLRSTIELSMQ 256
                       S T   DEE  Q+ LEL ++             RE ++L+S +E  + 
Sbjct: 305 -----------RSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVT 353

Query: 257 GSSGNTSQDLPK---------TSCVTPASEQPKKIKEDYFEKHQQ-----EQKQQQQQSD 302
             +   S+ L +          +  + A    KK++ D  E+H +     E+ + Q Q +
Sbjct: 354 QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE 413

Query: 303 LPGHSSYLHERPTTSSRAI 321
           L      L ++  T+++ I
Sbjct: 414 LENLKEVLEDKLNTANQEI 432


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 44/199 (22%), Positives = 87/199 (43%), Gaps = 36/199 (18%)

Query: 148 LANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLN-GKKLVKQKEHRVYK 206
           LA    RLQQQA  + +    +   +A Q+ Q ++++++++ K    ++L + +E R + 
Sbjct: 365 LAAARERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFL 424

Query: 207 TVLEKVSEESDESGTSDQDEEDFQRALELSRQET----------NREDEHLRSTIELSMQ 256
                       S T   DEE  Q+ LEL ++             RE ++L+S +E  + 
Sbjct: 425 -----------RSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVT 473

Query: 257 GSSGNTSQDLPK---------TSCVTPASEQPKKIKEDYFEKHQQ-----EQKQQQQQSD 302
             +   S+ L +          +  + A    KK++ D  E+H +     E+ + Q Q +
Sbjct: 474 QLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQE 533

Query: 303 LPGHSSYLHERPTTSSRAI 321
           L      L ++  T+++ I
Sbjct: 534 LENLKEVLEDKLNTANQEI 552


>gi|27597090 suppressor of Ty 6 homolog [Homo sapiens]
          Length = 1726

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 67/283 (23%), Positives = 114/283 (40%), Gaps = 60/283 (21%)

Query: 39  QLDEEE----RMRMAEGGVTSEEYLAFLQ--QPSENMDDTGFFSIQVISNALKFWGLEII 92
           +L+EE     R   A   ++ +E   +L   QP+ +    G  +IQ I  AL F   +  
Sbjct: 312 ELEEEADWIYRNAFATPTISLQESCDYLDRGQPASSFSRKGPSTIQKIKEALGFMRNQ-- 369

Query: 93  HFNNPE---YQKLGIDP---INERSFICNYKQHWFTIRKFGKHWFNLNSLLAGPELISDT 146
           HF  P    Y+K  ++P   IN+   +  + + W  +R                  I   
Sbjct: 370 HFEVPFIAFYRKEYVEPELHINDLWRVWQWDEKWTQLR------------------IRKE 411

Query: 147 CLANFLARLQQQAYSVFVVKGDLPDCEADQLL------QIISVEEMDTPK--------LN 192
            L     ++Q   Y       D P  +  + L      ++  V+ MD  K          
Sbjct: 412 NLTRLFEKMQAYQYEQISADPDKPLADGIRALDTTDMERLKDVQSMDELKDVYNHFLLYY 471

Query: 193 GKKLVK-QKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTI 251
           G+ + K Q   +  +  L++V EE DE G  D+ E++ QR  EL  ++ +R D +     
Sbjct: 472 GRDIPKMQNAAKASRKKLKRVREEGDEEGEGDEAEDEEQRGPEL--KQASRRDMY----- 524

Query: 252 ELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQ 294
             ++  S+G     L K   +TP  EQ  +   D +++H+ EQ
Sbjct: 525 --TICQSAG--LDGLAKKFGLTP--EQFGENLRDSYQRHETEQ 561


>gi|19923844 coiled-coil domain containing 82 [Homo sapiens]
          Length = 544

 Score = 37.4 bits (85), Expect = 0.021
 Identities = 46/182 (25%), Positives = 76/182 (41%), Gaps = 26/182 (14%)

Query: 180 IISVEEMDTPKLNGKKLVKQKEHRV--YKTVLEKVSE--ESDESGTSDQDEEDFQRALEL 235
           +I V   +T + N K  V +++ RV   +T    +S+  +SDE    + D E+F    EL
Sbjct: 1   MIHVRRHETRR-NSKSHVPEQKSRVDWRRTKRSSISQLLDSDE----ELDSEEFDSDEEL 55

Query: 236 SRQETNREDEHLRST--------------IELSMQGSSGNTSQDLPKTSCVTPASEQPKK 281
              E+   DE L S               + LS   S GN S+ L  +   +   E+  K
Sbjct: 56  DSDESFENDEELDSNKGPDCNKTPGSERELNLSKIQSEGNDSKCLINSGNGSTYEEETNK 115

Query: 282 IKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSSRAIESDLSDDISEGTVQAAVDTI 341
           IK    +   QE+   Q+ +DL   +  + E       + E    +D+++ T Q   D +
Sbjct: 116 IKHRNIDLQDQEKHLSQEDNDLNKQTGQIIEDDQEKHLSQE---DNDLNKQTGQIIEDDL 172

Query: 342 LE 343
            E
Sbjct: 173 EE 174


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 10/110 (9%)

Query: 198 KQKEHRVYKTVL----EKVSEESDESGTSDQDEEDFQRALE-----LSRQETNREDEHLR 248
           ++KE R  +TVL    EK+ EE  +     Q+EE+  R LE       RQE  ++ + LR
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301

Query: 249 STIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQ 298
              +L  +       Q   +        EQ ++ +E    + Q+E+++QQ
Sbjct: 302 REQQLRRKQEEERREQQEERRE-QQERREQQEERREQQLRREQEERREQQ 350



 Score = 34.7 bits (78), Expect = 0.13
 Identities = 29/137 (21%), Positives = 60/137 (43%), Gaps = 8/137 (5%)

Query: 184  EEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDE------EDFQRALELSR 237
            EE    +   ++L  Q+  R ++   E++ +E +E     Q        E+ Q  LE   
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREE-EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834

Query: 238  QETNRE-DEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQ 296
            Q   +E D   R+  + + Q  S    Q+L +        E+ +K++E++  + Q+E+++
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894

Query: 297  QQQQSDLPGHSSYLHER 313
             +Q  ++       H R
Sbjct: 1895 HRQVGEIKSQEGKGHGR 1911



 Score = 32.3 bits (72), Expect = 0.66
 Identities = 24/123 (19%), Positives = 55/123 (44%), Gaps = 4/123 (3%)

Query: 198 KQKEHRVYKTVLEKVSEESDESGTSDQDEE----DFQRALELSRQETNREDEHLRSTIEL 253
           +Q+E R  +   E+  E  ++    +Q+EE      +R  +L R++  R ++ LR   +L
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQL 401

Query: 254 SMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHER 313
             +       Q   +         + ++ +E + +KH+QE+++Q+ + +      +L   
Sbjct: 402 RREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKRE 461

Query: 314 PTT 316
             T
Sbjct: 462 EET 464



 Score = 28.9 bits (63), Expect = 7.3
 Identities = 22/106 (20%), Positives = 45/106 (42%), Gaps = 6/106 (5%)

Query: 199  QKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETN--REDEHLRSTIELSMQ 256
            +KE ++ +   E++  E  E     + E  ++   +L ++E    RE+   R   E   Q
Sbjct: 900  RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959

Query: 257  GSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSD 302
                   Q   +        E+P+K +    EK  +E+++ QQ+ +
Sbjct: 960  YRKDKKLQQKEEQLL----GEEPEKRRRQEREKKYREEEELQQEEE 1001


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 31/178 (17%)

Query: 145 DTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRV 204
           ++ L     RLQQ+  S         + EA +  Q +  ++   P+ + K L+ Q++ R+
Sbjct: 348 ESTLRREFLRLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRI 398

Query: 205 YKTVLEKVSEESDESGTSDQ---DEEDFQRALE--------LSRQETNREDEHLRSTIEL 253
            +   E+   E  +    +Q    E++ QR LE          R++  RE E+ R  +E 
Sbjct: 399 EEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE 458

Query: 254 SMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLH 311
             Q  S    + L +      + +Q         ++ QQ+ ++QQQQ  LPG    L+
Sbjct: 459 QRQ--SERLQRQLQQEHAYLKSLQQ---------QQQQQQLQKQQQQQLLPGDRKPLY 505



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 23/174 (13%)

Query: 161 SVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQK----EHRVYKTVLEK----- 211
           ++ + +G  P C+   +  +  +     P+L  KK  K+     +  + KT L +     
Sbjct: 223 AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQ 282

Query: 212 ------VSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQ- 264
                 + ++  E     Q ++   R+ +   ++   E E+  S  E    G  G  S  
Sbjct: 283 LLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSI 342

Query: 265 -DLPKTSCVTPAS---EQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSY-LHER 313
            ++P  S +       +Q  K   +  +  QQ+Q QQQQQ D   H  + LH+R
Sbjct: 343 MNVPGESTLRREFLRLQQENKSNSEALK--QQQQLQQQQQRDPEAHIKHLLHQR 394


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 31/178 (17%)

Query: 145 DTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRV 204
           ++ L     RLQQ+  S         + EA +  Q +  ++   P+ + K L+ Q++ R+
Sbjct: 348 ESTLRREFLRLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRI 398

Query: 205 YKTVLEKVSEESDESGTSDQ---DEEDFQRALE--------LSRQETNREDEHLRSTIEL 253
            +   E+   E  +    +Q    E++ QR LE          R++  RE E+ R  +E 
Sbjct: 399 EEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE 458

Query: 254 SMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLH 311
             Q  S    + L +      + +Q         ++ QQ+ ++QQQQ  LPG    L+
Sbjct: 459 QRQ--SERLQRQLQQEHAYLKSLQQ---------QQQQQQLQKQQQQQLLPGDRKPLY 505



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 23/174 (13%)

Query: 161 SVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQK----EHRVYKTVLEK----- 211
           ++ + +G  P C+   +  +  +     P+L  KK  K+     +  + KT L +     
Sbjct: 223 AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQ 282

Query: 212 ------VSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQ- 264
                 + ++  E     Q ++   R+ +   ++   E E+  S  E    G  G  S  
Sbjct: 283 LLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSI 342

Query: 265 -DLPKTSCVTPAS---EQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSY-LHER 313
            ++P  S +       +Q  K   +  +  QQ+Q QQQQQ D   H  + LH+R
Sbjct: 343 MNVPGESTLRREFLRLQQENKSNSEALK--QQQQLQQQQQRDPEAHIKHLLHQR 394


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 31/178 (17%)

Query: 145 DTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRV 204
           ++ L     RLQQ+  S         + EA +  Q +  ++   P+ + K L+ Q++ R+
Sbjct: 348 ESTLRREFLRLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRI 398

Query: 205 YKTVLEKVSEESDESGTSDQ---DEEDFQRALE--------LSRQETNREDEHLRSTIEL 253
            +   E+   E  +    +Q    E++ QR LE          R++  RE E+ R  +E 
Sbjct: 399 EEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE 458

Query: 254 SMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLH 311
             Q  S    + L +      + +Q         ++ QQ+ ++QQQQ  LPG    L+
Sbjct: 459 QRQ--SERLQRQLQQEHAYLKSLQQ---------QQQQQQLQKQQQQQLLPGDRKPLY 505



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 23/174 (13%)

Query: 161 SVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQK----EHRVYKTVLEK----- 211
           ++ + +G  P C+   +  +  +     P+L  KK  K+     +  + KT L +     
Sbjct: 223 AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQ 282

Query: 212 ------VSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQ- 264
                 + ++  E     Q ++   R+ +   ++   E E+  S  E    G  G  S  
Sbjct: 283 LLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSI 342

Query: 265 -DLPKTSCVTPAS---EQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSY-LHER 313
            ++P  S +       +Q  K   +  +  QQ+Q QQQQQ D   H  + LH+R
Sbjct: 343 MNVPGESTLRREFLRLQQENKSNSEALK--QQQQLQQQQQRDPEAHIKHLLHQR 394


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 37.0 bits (84), Expect = 0.027
 Identities = 42/178 (23%), Positives = 76/178 (42%), Gaps = 31/178 (17%)

Query: 145 DTCLANFLARLQQQAYSVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQKEHRV 204
           ++ L     RLQQ+  S         + EA +  Q +  ++   P+ + K L+ Q++ R+
Sbjct: 348 ESTLRREFLRLQQENKS---------NSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRI 398

Query: 205 YKTVLEKVSEESDESGTSDQ---DEEDFQRALE--------LSRQETNREDEHLRSTIEL 253
            +   E+   E  +    +Q    E++ QR LE          R++  RE E+ R  +E 
Sbjct: 399 EEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE 458

Query: 254 SMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLH 311
             Q  S    + L +      + +Q         ++ QQ+ ++QQQQ  LPG    L+
Sbjct: 459 QRQ--SERLQRQLQQEHAYLKSLQQ---------QQQQQQLQKQQQQQLLPGDRKPLY 505



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 38/174 (21%), Positives = 70/174 (40%), Gaps = 23/174 (13%)

Query: 161 SVFVVKGDLPDCEADQLLQIISVEEMDTPKLNGKKLVKQK----EHRVYKTVLEK----- 211
           ++ + +G  P C+   +  +  +     P+L  KK  K+     +  + KT L +     
Sbjct: 223 AIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQ 282

Query: 212 ------VSEESDESGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQ- 264
                 + ++  E     Q ++   R+ +   ++   E E+  S  E    G  G  S  
Sbjct: 283 LLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSI 342

Query: 265 -DLPKTSCVTPAS---EQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSY-LHER 313
            ++P  S +       +Q  K   +  +  QQ+Q QQQQQ D   H  + LH+R
Sbjct: 343 MNVPGESTLRREFLRLQQENKSNSEALK--QQQQLQQQQQRDPEAHIKHLLHQR 394


>gi|33286444 mastermind-like 2 [Homo sapiens]
          Length = 1156

 Score = 36.6 bits (83), Expect = 0.035
 Identities = 20/95 (21%), Positives = 46/95 (48%)

Query: 224 QDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIK 283
           Q ++  Q+  +  +Q+  ++ +  +   +   Q SS +  Q   + S ++   +Q ++ +
Sbjct: 588 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQ 647

Query: 284 EDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSS 318
           +   ++ QQ+Q+QQQQQ      +  L  +P   S
Sbjct: 648 QQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRS 682



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 17/87 (19%), Positives = 38/87 (43%)

Query: 221 TSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPK 280
           T  Q ++  Q+  +  +Q+  ++ +  +   +      S    Q    +       +Q +
Sbjct: 587 TQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQ 646

Query: 281 KIKEDYFEKHQQEQKQQQQQSDLPGHS 307
           + ++   ++ QQ+Q+QQQQ S  P  S
Sbjct: 647 QQQQQQQQQQQQQQQQQQQPSSQPAQS 673



 Score = 28.5 bits (62), Expect = 9.6
 Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 1/64 (1%)

Query: 237 RQETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQ 296
           RQ   +   H  S  + + Q  S   SQ+ P     T   +Q ++ ++   ++ QQ+Q+Q
Sbjct: 552 RQGNTKPLFHFNSD-QANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQ 610

Query: 297 QQQQ 300
           QQQQ
Sbjct: 611 QQQQ 614


>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
          Length = 248

 Score = 36.6 bits (83), Expect = 0.035
 Identities = 30/148 (20%), Positives = 61/148 (41%), Gaps = 19/148 (12%)

Query: 182 SVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQETN 241
           S E++ +   +  K  ++K+ R  K+     S  S +S +S  D ED          E  
Sbjct: 76  SREKLLSGNESSSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSED----------EEK 125

Query: 242 REDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQS 301
           ++ +  +     S + S  +T +           SE  + +K+    K + E+++  +  
Sbjct: 126 KQGKRRKKKKNRSYKSSQSSTHES---------ESESKESVKKKKKSKDETEKEKDVRSL 176

Query: 302 DLPGHSSYLHERPTTSSRAIESDLSDDI 329
                 SY  ++P +S  + ESD  +D+
Sbjct: 177 SKKRKKSYPDDKPLSSESSSESDYEEDV 204


>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
            containing [Homo sapiens]
          Length = 2863

 Score = 35.8 bits (81), Expect = 0.060
 Identities = 33/134 (24%), Positives = 52/134 (38%), Gaps = 24/134 (17%)

Query: 219  SGTSDQDEEDFQRALELSRQETNREDEHLRSTIELSMQGS---SGNTSQDLPKTSCVTPA 275
            S  S++D  +    L+ S  E   +D++    +EL ++GS     N   +L   S    A
Sbjct: 1083 SSPSEEDASEMPEFLDKSIVEEEEDDDY----VELKVEGSPTEEANLPTELQDNSLSPAA 1138

Query: 276  SE-----------------QPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERPTTSS 318
            SE                 + K + E   +   Q+ K    Q+     SS +    T S 
Sbjct: 1139 SEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTETQDSKDSGIQTMTASGSSAMSPETTVSQ 1198

Query: 319  RAIESDLSDDISEG 332
             A+ESDL   + EG
Sbjct: 1199 IAVESDLGQMLEEG 1212



 Score = 28.9 bits (63), Expect = 7.3
 Identities = 35/138 (25%), Positives = 61/138 (44%), Gaps = 14/138 (10%)

Query: 198  KQKEHRVYKTVLEKVSEESDE-SGTSDQDEEDFQRALELS--RQETNREDEHLRSTIELS 254
            K+    +++    KV EE    S TS Q     +R + +S   Q+ + +D  +       
Sbjct: 929  KENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFT-- 986

Query: 255  MQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQQQQSDLPGHSSYLHERP 314
               ++GN +  + KTS +  AS    +     +E    E K +Q+  +LP   + L E  
Sbjct: 987  ---TNGNENSSIEKTSSLESASNIELQTTNTSYE----EMKAEQENQELPDEGT-LEETL 1038

Query: 315  TTSSR-AIESDLSDDISE 331
            T  +R A + ++S DI E
Sbjct: 1039 TNETRNADDLEVSSDIIE 1056


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 35.4 bits (80), Expect = 0.078
 Identities = 26/114 (22%), Positives = 55/114 (48%), Gaps = 12/114 (10%)

Query: 198 KQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQ-----ETNREDEHLRSTIE 252
           ++ +HR  +  LE    E++++  S Q E + +   E +RQ     E     + L+  ++
Sbjct: 385 RRSQHRELQQALEGQLREAEQARASMQAEMELKEE-EAARQRQRIKELEEMQQRLQEALQ 443

Query: 253 LSMQGSSGNTSQDLPKTSCVTPASEQPKKI------KEDYFEKHQQEQKQQQQQ 300
           L ++      S  + +T  +    E+ K++      +E Y E+ QQE+++ QQ+
Sbjct: 444 LEVKARRDEESVRIAQTRLLEEEEEKLKQLMQLKEEQERYIERAQQEKEELQQE 497


>gi|34101288 cleavage and polyadenylation specific factor 2 [Homo
           sapiens]
          Length = 782

 Score = 34.7 bits (78), Expect = 0.13
 Identities = 38/153 (24%), Positives = 64/153 (41%), Gaps = 14/153 (9%)

Query: 179 QIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSRQ 238
           +I  +E     KL GK+L +  E    K    K  E+S E+     DE D +  ++   Q
Sbjct: 375 KITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDIEEDID---Q 431

Query: 239 ETNREDEHLRSTIELSMQGS---SGNTSQDLPKTSCVTPASEQPKKIK-EDYFEKHQQEQ 294
            +  + +H     +L M+G     G+  +   K+  + PA E+  +IK ++Y E  + E 
Sbjct: 432 PSAHKTKH-----DLMMKGEGSRKGSFFKQAKKSYPMFPAPEE--RIKWDEYGEIIKPED 484

Query: 295 KQQQQQSDLPGHSSYLHERPTTSSRAIESDLSD 327
               +        S L    T     ++ DLSD
Sbjct: 485 FLVPELQATEEEKSKLESGLTNGDEPMDQDLSD 517


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 34.7 bits (78), Expect = 0.13
 Identities = 24/137 (17%), Positives = 56/137 (40%)

Query: 178  LQIISVEEMDTPKLNGKKLVKQKEHRVYKTVLEKVSEESDESGTSDQDEEDFQRALELSR 237
            L++ S  E D  +   ++    +E    +   E+  ++ D+S   D+ E D +       
Sbjct: 1027 LELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEA 1086

Query: 238  QETNREDEHLRSTIELSMQGSSGNTSQDLPKTSCVTPASEQPKKIKEDYFEKHQQEQKQQ 297
             E +  D     T+ +    +   +S +  ++S    +SE      ED  E   +E++++
Sbjct: 1087 SEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEE 1146

Query: 298  QQQSDLPGHSSYLHERP 314
            +++ ++    S     P
Sbjct: 1147 EEEEEMVAEESMASAGP 1163


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,502,767
Number of Sequences: 37866
Number of extensions: 613990
Number of successful extensions: 5027
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 239
Number of HSP's that attempted gapping in prelim test: 4083
Number of HSP's gapped (non-prelim): 806
length of query: 355
length of database: 18,247,518
effective HSP length: 103
effective length of query: 252
effective length of database: 14,347,320
effective search space: 3615524640
effective search space used: 3615524640
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.